I EPA-56017-76-002 CURRENT AWARENESS SERVICE FOR TOXIC SUBSTANCES (CATS) f £• s «O«MU a CUMULATIVE REPORT NO. 2 PART I OFFICE OF TOXIC SUBSTANCES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C 20460 NOVEMBER 1976 ------- EPA-560/7-76-002 CURRENT AWARENESS SERVICE FOR TOXIC SUBSTANCES CUMULATIVE REPORT NO. 2 PART I November 1976 Contract No. 68-01-2694 Ernest W. Stalder Project Officer Office of Toxic Substances Environmental Protection Agency Washington, B.C. 20460 ------- FOREWORD Cumulative Report No. 2 of the Current Awareness Service for Toxic Sub- stances (CATS) covers the second year's service conducted for the Office of Toxic Substances (OTS) U.S. EPA under Contract No. 68-01-2694. The CATS is a scanning service of some 50 scientific journals, 30 trade jour- nals, and reports of major federal, state, and local environmental agencies. Scanning topics comprise a list of some 30 to 40 chemicals, classes of chemicals, and general topics related to chemicals in the environment. Abstracts or summaries of items of interest were prepared, indexed by subject and author, and compiled into biweekly CATS Reports. Mr. Ernest W. Stalder, Monitoring and Information Systems Branch, OTS, EPA Washington, DC is the Project Officer. Ms. Virginia Valeri and Ms. Anne V. Quinn, Literature Research Section, Arthur D. Little, Inc. Cambridge, MA were the Contract Managers. ------- TABLE OF CONTENTS SCANNING TOPICS JOURNALS SCANNED JOURNAL ABBREVIATIONS SUBJECT INDEX AUTHOR INDEX CATS BIWEEKLY REPORTS PART I Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. Report No. 27 28 29 30 31 32 33 34 35 36 37 38 39 PART II 40 41 42 43 44 45 46 47 48 49 50 51 52 1 2 4 6 30 40 66 88 109 142 174 198 225 237 275 305 336 375 402 427 460 483 512 542 567 603 634 665 694 716 735 ill L ------- SCANNING TOPICS + 1. Acetonitrile 2. Acrylonitrile 3. Arsenic 4. Aryl phosphates (phenyl, cresyl, mixed phenyl-cresyl) 5. Asbestos 6. Benzidine, and salts (hydrochloride, sulfate) 7. Boron 8. Brominated biphenyls 9. 3,3'-Dichlorobenzidine 10. Dioxane 11. Ethyleneimine 12. Flame retardants 13. Fluorocarbons 14. Haloethers 15. Hexachlorobenzene 16. Hexachlorobutadiene 17. Hydrazine, derivatives, and salts (sym and unsym - dimethyl, monomethyl) 18. Isocyanates (organic) 19. Liquefaction and gasification of coal 20. 4,4'-Methylenebis (2-chloroaniline) (MOCA) 21. Model Ecosystems (Environmental Fate Testing, Microecosystems) 22. Naphthylamines (alpha, beta, K[-phenyl derivatives) 23. Nitrilotriacetic acid (NTA) 24. Optical brighteners (fluorescent whitening agents, fluorescent dyes) 25. Perchloroethylene 26. Phthalates (dioctyl, di-2-ethylhexyl) 27. Polyurethanes 28. beta-Propiolactone 29. Trichloroethylene 30. Shale oil -xtraction and refining 31. Vinyl chloride 32. Vinylidene chloride 33. Ethylene dibromide *34. Nitrosamines * - Each topic was on the scanning list for part, though not necessarily all, of the contract year. + - Within each Biweekly Report abstracts on the above listed topics appear in the order given -1- ------- JOURNALS SCANNED JOURNALS Aerosol Age Air Pollution Control Association. Journal Ambio American Chemical Society. Journal American Dyestuff Reporter American Industrial Hygiene Association. Journal American Institute of Chemical Engineers Journal American Journal of Public Health American Medical Association. Journal American Review of Respiratory Disease Analytical Biochemistry Analytical Chemistry Annals of Occupational Hygiene Anti-Corrosion Methods and Materials Archives of Environmental Contamination and Toxicology Archives of Environmental Health Association of Official Analytical Chemists. Journal Atmospheric Environment Biochemistry Bioinorganic Chemistry Bioorganic Chemistry Biotechnology and Bioengineerlng British Journal of Cancer Bulletin of Environmental Contamination and Toxicology Cancer Research Chemical Engineering Chemical and Engineering News Chemical Engineering Progress Chemical Reviews Chemical Week Chemistry Chemistry and Industry. London Chemosphere Clinical Pharmacology and Therapeutics Coal Age Combustion Combustion and Flame Combustion Science and Technology Corrosion Environmental Health Perspectives Environmental Research Environmental Science and Technology European Journal of Cancer European Journal of Pharmacology Europlastics Farm Chemicals Fire Journal Food and Cosmetics Toxicology Geophysical Research Letters Household and Personal Products Industry Hydrocarbon Processing Industrial Research Industrial Water and Wastes International Journal of Cancer Journal of Agricultural and Food Chemistry Journal of Coatings Technology Journal of Experimental Marine Biology and Ecology Journal of Geophysical Research Journal of Occupational Medicine Journal of Paint Technology (Title changed to : Journal of Coatings Technology) Journal of Polymer Science Journal of Reproduction and Fertility Journal of Toxicology and Environmental Health Lancet Marine Pollution Bulletin Metal Progress Mining Congress Journal Modern Packaging Modern Plastics PERIOD OF COVERAGE August 1975 - July 1976 (except March, April) August 1975 - June 1976 Vol. It, No. 5 and 6, 1975; Vol. 5, No. 2, 1976 August 1975 - July 1976 August - November 1975; March - July 1976 August 1975 - July 1976 September 1975 - July 1976 (except March) August, October 1975; January, February, April, May 1976 November 10, 1975 - July 19, 1976 (except February 30, April 22, 30, June 14, July 12) August 1975 - July 1976 October 1975 - June 1976 August 1975 - August 1976 (except May) Vol. 18, Nos. 1 - 4, 1975 August 1975 - May 1976 Vol. 3, Nos. 2 and 3, 1975 August 1975 - August 1976 July 1975 - May 1976 August 1975 - May 1976 August 1975 - June 1976 Vol. 4, No. 2-4, 1975 Vol. 4, Nos. 1-4, 1975 August 1975 - July 1976 (except January) October 1975 - May 1976 July 1975 - July 1976 August - October 1975; April - July 1976 4 August 1975 - 2 August 1976 (except 1, 15 September, 22 December, 19 July) August 1975 - July 1976 August 1975 - July 1976 August 1975 - August 1976 6 August 1975 - 21 July 1976 (except 7 July) September 1975 - July 1976 20 December 1975 - 3 July 1976 August 1975 - June 1976 October 1975 - July 1976 August 1975 - July 1976 (except May) August 1975 - July 1976 (except May) August 1975 - April 1976 Vol. 11, Nos. 3 and 4, 1975; Vol. 12, Nos. 1-3, 1976 September 1975 - June 1976 December 1975; February 1976 August 1975 - June 1976 (except April) August 1975 - August 1976 February - July 1976 January - July 1976 (except April) September 1975 - April 1976 (except December) January - March 1976 September 1975 - July 1976 August 1975 - June 1976 June 1975 - April 1976 August 1975 - July 1976 (except December) August 1975 - June 1976 (except April) January - July 1976 (except May) July, August, September, October 1975 July 1975 - June 1976 September 1975 - June 1976 January - July 1976 July - December 1975 Vol. 81, Nos. 1-14, January - May 1976 (except Nos. 3, 12, 13) January - June 1976 August - December 1975 August 1975 - July 1976 October - December 1975) September 1975 - May 1976 2 August 1975 - 17 July 1976 (except 9 August, 26 June, 10 July) June 1975 - January 1976 (except September) December 1975 - June 1976 December 1975 - April 1976 August 1975 - July 1976 (except December) August 1975 - July 1976 (except May) -2- ------- PERIOD OF COVERAGE Mount Sinai Journal of Medicine Mutation Research Nature New England Journal of Medicine New Scientist Pollution Engineering Pure and Applied Geophysics Quarterly Review of Biology Reviews of Geophysics and Space Physics Rubber Age Science Soap, Cosmetics Chemical Specialties Technical Association of the Pulp and Paper Industry Teratology Textile Chemists and Colorist Textile World Toxicology and Applied Pharmacology U.S. National Cancer Institute. Journal Water and Wastes Engineering Water Pollution Control Federation. Journal Water Research January - April 1976 November 1975 - June 1976 (except May) 7 August 1975 - 29 July 1976 (except 20 November) 8 April - 5 August 1976 22 January, 26 February, 6 May 1976 August 1975 - July 1976 Vol. 113, Nos. 3-6, 1975; Vol. 114, No. 1, 1976 Vol. 50, No. 2 and 3, 1975; Vol. 51, No. 1, 1976 February 1975 - February 1976 August 1975 - June 1976 1 August 1975 - 6 August 1976 (except 20 February) August 1975 - July 1976 January, February, June 1976 August 1975 - June 1976 September 1975 - July 1976 August 1975 - July 1976 (except September) October 1975 - June 1976 November 1975 - June 1976 January - March 1976 August 1975 - May 1976 August 1975 - July 1976 -3- ------- JOURNAL ABBREVIATIONS * AIChE J. AIR/WATER Pollut. Rept. Am. Ceram. Soc., Bull. Am. Dyest. Rep. Am. Ind. Hyg. Assoc., J. Am. J. Pathol. Am. Rev. Respir. Dis. Anal. Chem. Ann. N.Y. Acad. Sci. Ann. Occup. Hyg. Annu. Rev. Pharmacol. Toxlcol. Appl. Environ. Mlcroblol. Arch. Environ. Contain. Toxlcol. Arch. Environ. Health Arch. Toxlcol. Atmos. Environ. American Institute of Chemical Engineers Journal AIR/WATER Pollution Report American Ceramic Society. Bulletin American Dyestutf Reporter American Industrial Hygiene Association. Journal American Journal of Pathology American Review of Respiratory Disease Analytical Chemistry New York Academy of Sciences. Annals Annals of Occupational Hygiene Annual Review of Pharmacology and Toxicology Applied and Environmental Microbiology Archives of Environmental Contamination and Toxicology Archives of Environmental Health Archives of Toxicology Atmospheric Environment Biochem. Biophys. Res. Commun. Biochem. Pharmacol. Br. J. Cancer Br. Med. J. Bull. Environ. Contarn. Toxlcol. Bull. N.Y. Acad. Med. Biochemical and Biophysical Research Communications Biochemical Pharmacology British Journal of Cancer British Medical Journal Bulletin of Environmental Contamination and Toxicology New York Academy of Medicine. Bulletin Can. Chem. Process. Can. J. Biochem. Cancer Res. Chem. Eng. Chem. Eng. News Chem. Eng. Prog. Chem. Ind. (London) Chem. Week Clin. Sci. Mol. Med. Canadian Chemical Processing Canadian Journal of Biochemistry Cancer Research Chemical Engineering Chemical and Engineering News Chemical Engineering Progress Chemistry and Industry. London Chemical Week Clinical Science and Molecular Medicine Environ. Health Lett. Environ. Health Perspect. Environ. Rep. Environ. Res. Environ. Sci. Technol. Eur. J. Cancer Eur. Plast. News Environmental Health Letter Environmental Health Perspectives Environment Report Environmental Research Environmental Science and Technology European Journal of Cancer European Plastics News Farm Chem. Fed. Proc., Fed. Am. Soc. Exp. Blol. Fed. Regist. Food Cosmet. Toxicol. Farm Chemicals Federation of American Societies for Experimental Biology. Federation Proceedings Federal Register Food and Cosmetics Toxicology Geophys. Res. Lett. Geophysical Research Letters Household and Pers. Prod. Ind. Hydrocarbon Process. Household and Personal Products Industry- Hydrocarbon Processing Ind. Eng. Chem., Process Des. Dev. Int. J. Cancer Industrial and Engineering Chemistry, Process Design and Development International Journal of Cancer Job Saf. Health Rep. J. Agrlc. Food Chem. J. Air Pollut. Control Assoc. J. Am. Dent. Assoc. J. Am. Med. Assoc. J. Am. Water Works Assoc. J. Assoc. Off. Anal. Chem. J. Coat. Technol. J. Geophys. Res. J. Nat. Cancer Inst. J. Nutr. J. Occup. Med. J. Paint Technol. J. Pharm. Sci. J. Polym. Sci., Polym. Chem. Ed. J. Polym. Sci., Lett. Ed. J. Toxlcol. Environ. Health J. Water Pollut. Control Fed. Job Safety and Health Report Journal of Agricultural and Food Chemistry Air Pollution Control Association. Journal American Dental Association. Journal American Medical Association. Journal American Water Works Association. Journal Association of Official Analytical Chemists. Journal Journal of Coatings Technology Journal of Geophysical Research U.S. National Cancer Institute. Journal Journal of Nutrition Journal of Occupational Medicine Journal of Paint Technology Journal of Pharmaceutical Sciences Journal of Polymer Science. Polymer Chemistry Edition Journal of Polymer Science. Polymer Letters Edition Journal of Toxicology and Environmental Health Water Pollution Control Federation. Journal ^Includes some journals not on core list of journals scanned ------- Mar. Pollut. Bull. Med. Lav. Mod. Packag. Mod. Plast. Mt. Sinai J. Med. Mutat. Res. Marine Pollution Bulletin Medlcina del Lavoro Modem Packaging Modern Plastics Mount Slnal Journal of Medicine Mutation Research N. Engl. J. Med. NYS Environ. New England Journal of Medicine New York State Environment Occup. Health Saf. Lett. Occupational Health and Safety Letter Pollut. Eng. Proc. R. Soc. Med. Proc. Soc. Exp. Biol. Med. Pure Appl. Chem. Pollution Engineering Royal Society of Medicine, London. Proceedings Society for Experimental Biology and Medicine. Proceedings Pure and Applied Chemistry Res./Dev. Rev. Geophys. Space Phys. Research/Development Reviews of Geophysics and Space Physics Schweiz. Med. Vochenschr. Scl. Am. Sci. News Soap, Cosmet. Chem. Spec. South. Med. J. Schweizerische Medinische Wochenschrift Scientific American Science News Soap, Cosmetics Chemical Specialties Southern Medical Journal Technol. Rev. Tetrahedron Lett. Text. Chem. Color. Text. World Toxicol. Appl. Pharmacol. Technology Review Tetrahedron Letters Textile Chemist and Colorist Textile World Toxicology and Applied Pharmacology Water Res. Water Research -5- ------- SUBJECT INDEX Ref. No.* 52-0001 ACETONITRILE, enzyme system for metabolism of 35-0001 ACETONITRILE, possible by-product of Sohlo process for manufacture of acrylonltrile 34-0001 ACETONITRILE, solvent In new leaching method for recovery of copper from ores or tailings 52-0001 ACETONITRILE, source of carbon and nitrogen for growth of Nocardia rhodochrous LL100-21 41-0028 a-ACETOXYNITROSOPYRROLIDINE, mutagenic per se requiring no liver activation 46-0027 ACETYLHYDRAZINE, mechanism in toxicity 46-0001 ACRYLONITHILE, among 23 chemicals for which NIOSH nay develop recommended standards for occupational exposure to by 1980 37-0002 ACRYLONITRILE, copolymer with vinylidene chloride as substitute for Ti02 in papermaking 46-0005 ACRYLONITRILE, deep-well injection of effluents from Monsanto's British plant is not feasible 35-0001 ACRYLONITHILE, description of Sohio process for manufacture of 40-0001 ACRYLONITRILE, Du Pont will expand capacity by 100 million Ib/year 46-0005 ACRYLONITRILE, effluents containing organics, nitriles, and ammonium sulfate will still be dumped into the river Tees in England following failure of deep-well injection attempt by Monsanto 41-0001 ACRYLONITRILE, exports in 1975 were about 198 million Ib or 28.3% more than in 1974 49-0004 ACRYLONITRILE, FDA sets interim leaching levels for beverage bottles 46-0006 ACRYLONITRILE, FDA vouches for its safety in food-contact articles but Natural Resources Defense Council wants courts to ban FDA approval of use of plastic beverage bottles 33-0001 ACRYLONITRILE, kinetics of radical polymerization in presence of triphenyl phosphite 49-0003 ACRYLONITRILE, migration and potential toxicity in nitrile barrier polymer containers 43-0002 ACRYLONITRILE, Monsanto1s new Texas City, Texas plant scheduled for 1976 completion said to be world's largest 47-0001 ACRYLONITRILE, new catalyst developed by Japanese company cuts by-product yield and offers economic benefits as well as higher acrylonitrile yield 43-0001 ACRYLONITRILE, new catalyst developed by Japanese company gives higher yields than Sohio1s catalyst-41 48-0001 ACRYLONITRILE, new transparent high-oxygen-barrier can for hot-filled acidic foods 34-0002 ACRYLONITRILE, offshore projects may contribute to capacity increase in 1981 46-0002 ACRYLONITRILE, OSHA is proposing an exposure limit of 20 ppm for worker protection 27-0001 ACRYLONITRILE, overview of rubber compounding 33-0002 ACRYLONITRILE, photopolymerlzatlon in presence of substituted triphenyl phosphites 34-0002 ACRYLONITRILE, possible shortage for acrylic fiber needs in 1977 and 1980 49-0002 ACRYLONITRILE, potential health hazards when used as a polymer raw material 49-0001 ACRYLONITRILE, price Increase of 1.5c/lb announced by Monsanto 48-0002 ACRYLONITIRLE, production drop in 1975 46-0003 ACRYLONITRILE, production in 1975 dropped to 1.22 billion Ib compared to 1.41 billion Ib in 1974 37-0001 ACRYLONITRILE, production rise anticipated in 1976 46-0004 ACRYLONITRILE, recovery in demand for this chemical will help boost propylene market 35-0002 ACRYLONITRILE, Reichhold Chemicals set to buy Standard Brands Chemical Industries which produces acrylonitrile 52-0001 ACRYLONITRILE, source of nitrogen for growth of Nocardia rhodochrous LL100-21 39-0029 ACTINOMYCIN D, mutageniclty in Neurospora erassa 42-0010 ACTIVATED CARBON, effective adsorbent for removing aerosol propellants from air 45-0038 ADHESIVE, effect of exposure to fumes from heat-activated product 43-0013 AEROSOL SPRAYS, respiratory symptoms in humans 44-0015 AEROSOLS, lung function changes in humans inhaling hair sprays 46-0018 AEROSOLS, production in 1974 rose to over two billion units or 14X higher than 1973 In free world outside U.S. and Canada 44-0015 AEROSOLS, respiratory deposition of hair sprays in humans 35-0020 AMD-4, new fuel additive said to be better antloxidant than MD 46-0049 AMERICIUM, potential as environmental pollutant 35-0047 ANTIMONY, Asarco Inc.'s $7-million, 5 ton/day El Paso refinery to be onstream by late 1976 using reverberatory-type furnace smelter 43-0004 ANTIMONY, high concentrations in adrenal tissues of guinea pigs fed Swiss chard grown on sewage sludge fortified soil 43-0040 ANTIMONY, low doses shorten rat's life span 43-0040 ANTIMONY, trace amounts in air may be potential health hazard 27-0001 ANTIMONY OXIDE, aid to the effectiveness of halogenated compounds used as additives to reduce flammability of polymers 41-0001 ANTIMONY OXIDE, Imports In 1975 of about 19.8 million Ib were 58.1Z more than in 1974 27-0039 ANTIMONY PENTAFLUORIDE, reaction with hydrogen fluoride yields new solid oxonium salts 42-0020 ANTIMONY TRIOXIDE, flame retardant additive for flame retardant urethane coatings for tenting materials 38-0020 AQUATIC ECOLOGY, effects of TNT manufacturing operations on water quality and stream biota 47-0021 AQUATIC ECOSYSTEMS, nutrient dynamics and gas production in 48-0019 AQUEOUS PHASE CATALYTIC OXIDATION, potentially economic wastewater treatment for coal conversion and shale oil recovery plant pollutants 29-0003 AROMATIC COMPOUNDS, potential bladder carcinogens 52-0006 ARSENIC, ambient level approach to control of occupational cancerigenlc exposures 48-0003 ARSENIC, analysis in soils 52-0005 ARSENIC, analysis of airborne copper smelter partlculate samples 33-0004 ARSENIC, Asarco is denied an arsenic emissions standard variance for its Tacoma smelter 36-0001 ARSENIC, carcinogenic to man 52-0005 ARSENIC, chemistry In airborne copper smelter participates 43-0004 ARSENIC, concentration in tissues of guinea pigs fed Swiss chard grown on sewage sludge . fortified soil 39-0002 ARSENIC, content in edible seafoods 43-0003 ARSENIC, criteria for a recommended standard-occupational exposure to inorganic arsenic 32-0002 ARSENIC, detection in surface water by atomic absorption *Number preceding the hyphen identifies the CATS Biweekly Report; number following the hyphen identifies the abstract within the report. -6- ------- Ref. No. 33-0005 ARSENIC, detection of arsenic acids in pesticides and In environmental samples 52-0004 ARSENIC, determination in urine of exposed workers 39-0001 ARSENIC, determination of toxic trace elements in body fluid - reference samples 35-0003 ARSENIC, effect on fetal growth 40-0004 ARSENIC, effect on rat kidney 37-0003 ARSENIC, forms found in air 50-0001 ARSENIC, health hazard to workers 50-0003 ARSENIC, hearing on proposed standard 41-0003 ARSENIC, high levels found in soil near herbicide distributor in Virginia 40-0003 ARSENIC, high levels in marine organisms indicate arsenic to be organically bound and less toxic than inorganic arsenic 50-0001 ARSENIC, human carcinogen 52-0003 ARSENIC, incidence of skin cancer and drinking water level 52-0003 ARSENIC, Incidence rate for carcinoma and risk from urban drinking water levels 44-0001 ARSENIC, inorganic interference in analysis with atomic absorption spectrometry 33-0006 ARSENIC, levels in house dusts in Hawaii 50-0001 ARSENIC, literature review 48-0004 ARSENIC, low temperature ashing not too satisfactory for determination of arsenic in atmospheric particulate samples 28-0018 ARSENIC, methods of removal from raw shale oil 35-0005 ARSENIC, one human carcinogen not found carcinogenic in animal tests 50-0002 ARSENIC, OSHA standard and inflation impact statement 50-0004 ARSENIC, OSHA standards delayed 33-0003 ARSENIC, pollution rules may force closing of Asarco smelter 34-0003 ARSENIC, possible interference with DNA repair might explain cocarcinogenic effect of some arsenic compounds 42-0002 ARSENIC, potential cause of rare liver cancer deaths of four people working with a calcium arsenate pesticide 44-0002 ARSENIC, potential environmental effects of organic and inorganic forms on nontarget animal species 44-0002 ARSENIC, potential food chain hazards 32-0001 ARSENIC, potential pollution of waterways by monosodium salt methanearsonic acid (MSMA) herbicide when applied to grass near highways 41-0003 ARSENIC, potential water contaminant in Virginia 49-0005 ARSENIC, presence in soil, water, food, and in hair of individuals near Ghana goldmine 43-0004 ARSENIC, presence in Swiss chard grown on sewage sludge fortified soil 35-0004 ARSENIC, radiochemical separation before gamma ray spectrometry 52-0004 ARSENIC, rapid and simple colorimetric method for monitoring urine concentrations at field locations 27-0002 ARSENIC, respiratory cancer and occupational exposure to 52-0006 ARSENIC, review of epidemiological and other findings concerning occupational exposure to 42-0001 ARSENIC, slow whole body response of fish to its presence in water suggests need for improved toxicity detection and measuring methods 40-0002 ARSENIC, temporary variance from arsenic emission standards indicated for Asarco's copper smelter at Tacoma, Washington 52-0002 ARSENIC, toxicity and accumulation in green sunfish 32-0001 ARSENIC, toxicity to fish of monosodium salt methanearsonic acid (MSMA) herbicide 44-0002 ARSENIC, toxicity to insect herbivores 31-0001 ARSENIC, transport through soil 41-0002 ARSENIC-CONTAMINATED WATER, possible cause of liver diseases 52-0002 ARSENICALS, effect on green sunfiah of exposures to high concentrations of aodlum arsenate in water 46-0011 ASBESTOS, airborne effects on man and animals 38-0006 ASBESTOS, airborne fibers now Implicated as potential carcinogens add new dimension to Reserve Mining case 37-0005 ASBESTOS, airborne particle sampler 30-0002 ASBESTOS, analytical chemistry 30-0002 ASBESTOS, animal toxicology and carclnogenesis 45-0003 ASBESTOS, autolranunlty as.mechanism for asbestosis 38-0003 ASBESTOS, bibliography of Industrial health hazards due to atmospheric factors 41-0006 ASBESTOS, cancer mortality rates among Russian mine workers 46-0010 ASBESTOS, carcinogenic behavior of 36-0001 ASBESTOS, carcinogenic to man 27-0003 ASBESTOS, carcinomas associated with exposure to 48-0040 ASBESTOS, cauae of asbestosis when carried home on workers' clothing 44-0007 ASBESTOS, changes in pulmonary function in household contacts of workers 31-0004 ASBESTOS, characterization and control of emissions from open sources 41-0005 ASBESTOS, chronic inhalation effects on hamsters also exposed to cigarette smoke 42-0002 ASBESTOS, concentrations of 2-201 of fibers detected in 9 commercial cosmetic talc products tested 30-0001 ASBESTOS, contamination effects and occupational precautions 27-0006 ASBESTOS, cost study of emission control for taconlte processing Industry underway 46-0007 ASBESTOS, currently marketed talc powders do not contain any asbestos according to testa conducted by the Cosmetic, Toiletry and Fragrance Association and by the FDA 37-0006 ASBESTOS, cytogenic effects in monkeys 44-0004 ASBESTOS, cytotoxic effects on rabbit lung fibroblasts 37-0007 ASBESTOS, deposit and retention of inhaled fibers 49-0008 ASBESTOS, detection techniques for pulmonary mineral dust 46-0009 ASBESTOS, dynamics of asbestosis caused by 31-0005 ASBESTOS, economic analysis of effluent guidelines for the industry 47-0002 ASBESTOS, effect of age at Inoculation on occurrence of mesothellomas In rats 37-0008 ASBESTOS, effect on DNA synthesis in the gastrointestinal tract 44-0004 ASBESTOS, effect on morphology and reticulin formation of cultured lung fibroblasts 45-0005 ASBESTOS, effects on pulmonary function 28-0002 ASBESTOS, efficiency of baghouses as dust collectors -7- ------- Ref. No. 32-0006 ASBESTOS, effluent limitations guidelines and performance standards for industry segments 27-0004 ASBESTOS, EPA orders Bendix plant to correct violation of emissions standards 46-0008 ASBESTOS, EPA will continue to monitor drinking waters of cities to determine potential health hazards from asbestos fibers present In the water 41-0004 ASBESTOS, estimating health risks in epidemiologic studies 50-0006 ASBESTOS, evidence supports safety of 2 fibers 45-0001 ASBESTOS, exposure monitoring records retention requirements for 52-0007 ASBESTOS, exposure of brake repair workers 47-0003 ASBESTOS, fatal malignant testicular mesothelioma in long-time pipe Insulator associated with his exposure to 43-0007 ASBESTOS, fibers released from insulation of gas chromatographs seen as potential health hazard •46-0010 ASBESTOS, fibrosis and asbestosls induced by 39-0003 ASBESTOS, health hazard to workers In automobile transmission parts manufacturing plant 48-0008 ASBESTOS, health hazards in dentistry 27-0005 ASBESTOS, health hazards of adhesives used for home repair work 35-0005 ASBESTOS, human and animal carcinogen 30-0002 ASBESTOS, human toxicology and carclnogenesls 51-0002 ASBESTOS, in drinking water 51-0005 ASBESTOS, in wall-repair compounds 29-0001 ASBESTOS, induction of chromosome changes In Chinese hamster cells by exposure to chrysotile and crocidolite fibers 48-0006 ASBESTOS, inhalation effects on hamsters exposed to cigarette smoke 38-0005 ASBESTOS, low concentrations in mottle dust deemed non-hazardous to employees 52-0009 ASBESTOS, lung cancer in insulation workers 30-0003 ASBESTOS, mechanisms involved in effects on lungs 51-0004 ASBESTOS, mesothellomas and population exposure 27-0003 ASBESTOS, multiple primary tumors in individuals exposed to 29-0001 ASBESTOS, mutagenic effects 35-0033 ASBESTOS, new Olin Corp. chlor-alkali plant will use Hooker process involving use of resin-stabilized asbestos diaphragms 40-0006 ASBESTOS, non-toxic dust concentrations in trimmings and braids manufacturing plant 28-0024 ASBESTOS, one of 13 carcinogens for which OSHA has published health standards 28-0001 ASBESTOS, OSHA cites PPG chlorine plant in Texas for violation of emissions standards 50-0005 ASBESTOS, OSHA requires yearly medical examination 31-0003 ASBESTOS, OSHA wants drastic reduction in employees' exposure limit 49-0009 ASBESTOS, performance and cost comparisons of new special ion-exchange membrane process and asbestos-diaphragm process in chlor-alkali manufacturing 44-0008 ASBESTOS, persons exposed to show higher rates of symptomatology and lung function Impairment than non-exposed persons in a community 43-0006 ASBESTOS, persulfonic acid resin film replacements for asbestos diaphragms cut chlor-alkali costs 30-0003 ASBESTOS, pneumoconiosis in workers 32-0005 ASBESTOS, pollution related to manufacturing, demolition, wastes disposal and related activities 29-0002 ASBESTOS, potential carcinogen for shipyard workers '33-0007 ASBESTOS, potential carcinogenic effects on WW II shipyard workers 48-0005 ASBESTOS, potential carcinogenic hazard of chrysotile 48-0006 ASBESTOS, potential cocarclnogen •45-0002 ASBESTOS, potential hazards of fibers in asbestos-cement spray used in construction 38-0004 ASBESTOS, potential health hazard and toxiclty relative to a cement factory 32-0003 ASBESTOS, potential Increasing market as filler for plastics 46-0008 ASBESTOS, presence In drinking waters of several large U.S. cities Is no cause for immediate concern according to EPA 48-0007 ASBESTOS, presence of ferruginous bodies In lungs of rural and urban dwellers not exposed occupationally to 43-0005 ASBESTOS, processed mineral fiber offered as substitute for many applications 37-0009 ASBESTOS, proposed air quality standard 47-0006 ASBESTOS, proposed air quality standard defended 47-0005 ASBESTOS, proposed air quality standard questioned 38-0002 ASBESTOS, quantitative determination of fibers in liquids and solids 40-0005 ASBESTOS, quantitative relationship of fecal asbestos to asbestos exposure 32-0005 ASBESTOS, rationale for proposed amendments to air pollution standards 32-0004 ASBESTOS, relationship between fibrogeniclty and hemolytic activity confirmed via rat erythrocytes 45-0004 ASBESTOS, release of fibers from protective clothing 42-0003- ASBESTOS, review of recent court cases indicates courts' view of Importance of reciprocal relationship between risk and harm in judging toxicity 51-0001 ASBESTOS, review of the literature 38-0001 ASBESTOS, review of uses and health hazards 36-0002 ASBESTOS, statistical analysis of airborne fiber counting in the laboratory and industrial environment 44-0006 ASBESTOS, surveillance of asbestos workers in Texas aimed at early detection of lung cancer 52-0010 ASBESTOS, TLV history and development 31-0001 ASBESTOS, transport through soil 39-0004 ASBESTOS, use of thermoanalytical methods to environmental health problems 27-0003 ASBESTOS, uses and exposures — occupational and nonoccupational 44-0005 ASBESTOS, visceral pleural changes in workers with significant long-term exposure to asbestos versus no similar effects In personnel exposed Intermittently 52-0008 ASBESTOS, workers health care after exposure 37-0004 ASBESTOS, X-ray diffraction analysis in air or water 37-0002 ASBESTOS FIBER, potential filler for paper 51-0003 ASBESTOS FIBERS, control In converter industries 44-0003 ASBESTOS FIBERS, depression of viral interferon induction in cell monolayers 47-0004 ASBESTOS FIBERS, environmental monitoring 29-0001 ASBESTOS FIBERS, mutagenic effects 39-0005 ASBESTOS-FREE TALC, uses ------- Ref. No. 46-0009 ASBESTOSIS, dynamics of 30-0002 ASBESTOSIS, reassessment of the problem 47-0038 ASPHALT, hot-mix emission study Indicates no serious air pollution or health hazards 29-0007 ATOMIC OXYGEN/AEROSOLS, chemical reactions In stratosphere leading to ozone depletion 29-0023 ATRAZINE, potential carcinogen 29-0023 ATRAZINE, widely-used pesticide found In drinking water could react with nitrite to form potential carcinogen in human stomach 46-0055 BACTERIAL INDICATORS, symposium on Indicators of potential health hazards associated with water 27-0033 BEHAVIORAL TOXICOLOGY, emerging discipline may lead to predicting potential toxicity of chemicals 47-0045 BENELITE, new beneficiated ilmenite ore offers environmentally clean process for manufacture of ri02 44-0038 BENZENE, implicated in 150 cases of leukemia 47-0043 BENZENE, inhalation tests at 100 ppm and 300 ppm fail to induce leukemia in rats and mice 45-0037 BENZENE, leukemia deaths in exposed workers under investigation 29-0003 BENZENE RING COMPOUNDS, potential bladder carcinogens 35-0005 BENZIDINE, animal studies useful in predicting human carcinogenic effects 47-0007 BENZIDINE, bladder-cancer deaths of British rubber workers on Increase despite discontinued use of 36-0001 BENZIDINE, carcinogenic to man 42-0004 BENZIDINE, colorlmetric assay for detection In urine and water 31-0006 BENZIDINE, environmental fate 30-0004 BENZIDINE, hepatropic action in mice 35-0005 BENZIDINE, human and animal carcinogen 39-0006 BENZIDINE, human bladder carcinogen 33-0008 BENZIDINE, more potent human carcinogen than 3,3'-dichlorobenzldine 40-0007 BENZIDINE, mutagenic activity in rats following dermal application and subcutaneous injection 38-0007 BENZIDINE, mutagenic potency 46-0012 BENZIDINE, new black dyes from Atlantic Chemical Corporation are benzidine-free products meeting OSHA's requirements for finishing plant effluents 39-0006 BENZIDINE, new dye manufacturing process reduced bladder tumor cases in workers during last 20 years 32-0007 BENZIDINE, non-tumorigenlc to fish liver 29-0003 BENZIDINE, potential bladder carcinogen 42-0005 BENZIDINE, presence In Kentucky school laboratories of potential carcinogens indicates need for schools to enforce safety standards for exposure 52-0011 BENZIDINE, substitutes or process changes in manufacturing 35-0006 BENZIDINE DIHYDROCHLORIDE, carclnogenicity in mice 44-0009 BENZIDINE DIHYDROCHLORIDE, hepatic cytologic and neoplastic changes in mice 39-0006 BENZIDINE SULFATE, carcinogenic hazard to dye workers 39-0011 BENZOIC ACID 2-(2,4,6-TRICHLOROPHENYL) HYDRAZIDE, photolysis products 46-0056 BENZYPHENOLS, newly synthesized compounds show promise as safe biocides 32-0018 BERYLLIUM, potential carclnogenicity demonstrated in rats prompts OSHA's new proposed occupational exposure standard 41-0035 BIOMASS CONVERSION, potential source of synthetic fuels and chemical feedstocks 36-0001 N,N-BIS(2-CHLOROETHYL)-2-NAPHTHYLAMINE, carcinogenic to man 35-0014 1,2-BIS(CHLOROMETHOXY)BUTANE, carciriogenicity in mice 35-0014 1,2-BIS(CHLOROMETHOXY)ETHANE, carclnogenicity in mice 35-0014 1,6-BIS(CHLOROMETHOXY)HEXANE, carclnogenicity in mice 35-0014 l,4-BIS(CHLOROMETHOXY)-p-XYLENE, carcinogenicity in mice 36-0001 BIS(CHLOROMETHYL) ETHER, carcinogenic to man 43-0015 BIS(CHLOROMETHYL) ETHER, detection in air 44-0018 BIS(CHLOROMETHYL) ETHER, detection in air at the ppb level with new automatic gas chromatographic monitor 31-0006 BIS(CHLOROMETHYL) ETHER, environmental fate 48-0013 BIS(CHLOROMETHYL) ETHER, epldemlologlcal survey of lung cancer following exposure to 35-0005 BIS(CHLOROMETHYL) ETHER, human and animal carcinogen 36-0010 BIS(CHLOROMETHYL) ETHER, monitoring with a portable mass spectrometer 38-0007 BIS(CHLOROMETHYL) ETHER, mutagenle potency 28-0024 BIS(CHLOROMETHYL) ETHER, one of 13 carcinogens for which OSHA has published health standards 48-0014 BIS (CHLOROMETHYL) ETHER, possible formation from the reactions of formaldehyde and commonly used chloride salts 49-0007 BIS(CHLOROMETHYL) ETHER, possible formation in paints containing both formaldehyde and chlorine containing resins 29-0004 BIS(CHLOROMETHYL) ETHER, potential bronchogenic carcinogen at low levels 48-0012 BIS(CHLOROMETHYL) ETHER, researchers Indicate that dlmethylcarbomoyl chloride may be more potent carcinogen than 47-0023 BIS(2-ETHYLHEXYL) PHTHALATE, effect on blood compatibility of polyvinyl chloride _47-0024 BIS(2-ETHYLHEXYL) PHTHALATE, nonspecific effect on hexobarbital sleep time in rats and mice 50-0029 l,2-BIS(ETHYLSULFONYL)-l,2-DiCHLOROETHYLENE,-se penetrating, irreversible corneal injury to rabbit eye produced by 35-0007 BORON, charged particle activation analysis 30-0005 BORON, detection in boronated fertilizers 31-0007 BORON, ecological investigation of accuracy of federal standard of permissible levels to water resources 31-0007 BORON, effect of drinking water permissible levels on cattle 50-0008 BORON; effect on gonads 50-0007 BORON, effect on reproduction 39-0007 BORON, environmental effects 47-0008 BORON, foliar Injury from emissions from Canadian appliance manufacturing and fiberglass manufacturing plants 36-0003 BORON, new ferrous metallic glasses 47-0008 BORON, phytotoxic air pollutant 44-0010 BORON, semiautomated method for analysis in surface water by atomic emission spectroscopy 50-0008 BORON, toxic effects 32-0036 BOWEL CANCER, possible occupational factors -9- ------- Ref. No. 35-0045 50-0011 41-0008 29-0004 41-0007 28-0003 47-0009 45-0006 30-0006 36-0007 44-0039 35-0049 42-0027 BRICK PLANTS, air emissions from four U.S. plants measured BROMINATED BIPHENYL, flame retardant chemical structure BROMINATED BIPHENYLS, major component of flame retardant Involved In accidental poisoning of cattle and other animals is identified BROMINATED BIPHENYLS, potential environmental hazards BROMINATED BIPHENYLS, potential toxiclty and teratogenicity in rodents of a commerical flame redardant BROMINATED BIPHENYLS, review of toxic effects of PBBs BROMINATED BIPHENYLS, teratogenic effects in rats BROMINATED BIPHENYLS, toxic effects from accidental mix-up with animal feeds BROMINATED BIPHENYLS, ultrastructure and morphogenesis of hepatocellular changes In rats BROMODICHLOROMETHANE, National Organics Reconnaissance Survey for halogenated organics BUTADIENE, possible health hazard in tire and rubber companies BUTYLATED MONOCHLORODIPHENYL OXIDE, environmentally safer PCS substitute N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE, bladder tumors in rats potentiated by administration of leupeptin 35-0046 CADMIUM, concentration in Pacific Ocean plankton 39-0040 CADMIUM, environmental occurrence and potential effects on health 40-0033 CADMIUM, potential cytogenetic effects 43-0040 CADMIUM, trace amounts in air are potential health hazards and should be controlled 36-0001 CADMIUM OXIDE AND SULFATE, carcinogenic to man 51-0030 CANCER, metal workers have elevated risk 48-0012 CANCER TESTING, toxlcologists criticize NCI's proposed testing procedures and goals 39-0018 CARBOFURAN, micro-biological fate 29-0012 CARBON DIOXIDE FLUX, method of approaching gross ecosystem energetics 36-0009 CARBON TETRACHLORIDE, economic impact assessment of possible regulatory action to control atmospheric emissions 40-0008 CARBON TETRACHLORIDE, estimated stratospheric concentration of gaseous chlorine compounds 36-0010 CARBON TETRACHLORIDE, monitoring with a portable mass spectrometer 36-0007 CARBON TETRACHLORIDE, National Organics Reconnaissance Survey for halogenated organics 44-0013 CARBON TETRACHLORIDE, no evidence that it has contributed to stratospheric ozone depletion 27-0010 CARBON TETRACHLORIDE, producers may have to convert some capacity to perchloroethylene if fluorocarbon ban goes Into effect 27-0010 CARBON TETRACHLORIDE, production threatened by potential ban of fluorocarbons 44-0013 CARBON TETRACHLORIDE, seen as greater contributor to atmospheric chlorine than fluorocarbons 11 and 12 47-0047 CARCINOGENS, EPA standardizes Its guidelines 45-0033 CARCINOGENS, standards for industrial control of 51-0031 CHEMICAL CARCINOGENS, industry adopts controversial "quick" tests (Ames Test) 27-0034 CHEMICALS, behavioral and latent effects of low level chemicals on humans 49-0038 CHLORALKALIES, factors affecting a changing world market 49-0041 CHLORAMINE, potential mutagen 49-0040 CHLORAMINES, potential hazard to aquatic life 41-0012 CHLORINATED DIPHENYL ETHERS, photochemical breakdown yields more toxic chlorinated dibenzofurans 38-0037 CHLORINATED ETHYLENES, atmospheric oxidation 29-0013 CHLORINATED HYDROCARBONS, persistence of low-and high-molecular-welght compounds In natural water bodies 27-0037 CHLORINATED KETONE, health hazard to workers in pesticide plant 37-0042 CHLORINE, explosion kills four and injures more 35-0031 2-CHLOROACETALDEHYDE, mutagenicity of this VC metabolite in mammalian cell system 31-0031 CHLOROACETALDEHYDE, possible metabolite of vinyl chloride is mutagenlc 36-0009 CHLOROCARBONS, economic impact assessment of possible regulatory action to control atmospheric emissions 31-0015 CHLORODIFLUOROMETHANE, fire extinguishing properties !46-0017 CHLORODIFLUOROMETHANE (FC-22), world production from start of commercial manufacture through 1975 set at 1,670 million Ib 35-0031 CHLOROETHYLENE OXIDE, mutagenicity of this VC metabolite in mammalian cell system 27-0010 CHLOROFLUOROCARBON, ban would affect carbon tetrachlorlde market 28-0006 CHLOROFLUOROCARBONS, action of sunlight on oxygen suggests re-formation of ozone In atmosphere 37-0013 CHLOROFLUOROCARBONS, analysis in troposphere by gas chromatography-mass spectrometry 39-0010 CHLOROFLUOROCARBONS, balloon probes will study reactions of F-ll and F-12 more than 50,000 feet above the earth 28-0005 CHLOROFLUOROCARBONS, detection of chlorine oxide in the atmosphere is part of MCA research 31-0013 CHLOROFLUOROCARBONS, effect on earth's thermal energy balance 38-0010 CHLOROFLUOROCARBONS, effect on stratospheric ozone may be different because of possible existence of a tropospheric sink 28-0004 CHLOROFLUOROCARBONS, effect of temperature on their breakdown In the stratosphere 31-0013 CHLOROFLUOROCARBONS, greenhouse effect on climate 31-0017 CHLOROFLUOROCARBONS, Increase in UV radiation from ozone depletion may reach 40Z 31-0016 CHLOROFLUOROCARBONS, mathematical computer model simulates ozone region to study effects of 28-0005 CHLOROFLUOROCARBONS, MCA research studies will be available to government 34-0005 CHLOROFLUOROCARBONS, misinformation and facts relative to ozone depletion in stratosphere •46-0013 CHLOROFLUOROCARBONS, photochemical decomposition related to their spectra 28-0004 CHLOROFLUOROCARBONS, photochemical mechanisms for their decomposition 46-0019 CHLOROFLUOROCARBONS, potentially safe alternatives for F-ll and F-12 in aerosols Include F-22, F-133a, F-142b, F-152a, and some of the 120 series 28-0010 CHLOROFLUOROCARBONS, stratospheric research balloon locates chlorofluorocarbons that apparently are breaking down to chlorine atoms 36-0011 CHLOROFLUOROCARBONS F-ll AND F-12, balloon-borne measurements show Increase In stratosphere over New Mexico 36-0009 CHLOROFLUOROCARBONS F-ll AND F-12, AND F-22, economic impact assessment of possible regulatory action to control atmospheric emissions 40-0012 CHLOROFLUOROMETHANES, atmospheric concentrations and their ozone depletion effects 40-0010 CHLOROFLUOROMETHANES, effect of fluorine atoms on ozone destruction in the stratosphere -10- ------- Ref. No. 44-0012 CHLOROFLUOROMETHANES, only substances currently seen as threat to stratospheric ozone 40-0012 CHLOROFLUOROMETHANES, possible biological and climatologlcal effects of stratospheric ozone depletion 36-0010 CHLOROFORM, monitoring with a portable mass spectrometer 30-0017 CHLOROFORM, potential cause of ozone depletion in atmosphere 42-0031 CHLOROFORM, potential liver carcinogen in mice 50-0025 CHLOROFORM, results of a carcinogenesis bioassay of 31-0038 CHLOROFORM, toxicity in mice genetically controlled 44-0024 CHLOROHYDROCARBONS, photodecomposition rates under simulated atmospheric conditions 45-0016 CHLOROHYDROCARBONS, residence times in atmosphere based on reactivity 40-0008 CHLOROMETHANE, estimated stratospheric concentration of gaseous chlorine compounds 44-0020 CHLOROMETHYL ETHERS, characteristics of induced lung cancers 44-0019 CHLOROMETHYL ETHERS, pulmonary effects on humans 48-0013 CHLOROMETHYL METHYL ETHER, epldemiological survey of lung cancer following exposure to 50-0010 CHLOROMETHYL METHYL ETHER, exposure and smoking habits 50-0010 CHLOROMETHYL METHYL ETHER, incidence of lung cancer 34-0014 CHLOROPROPANOLS, mutagenic residue from propylene oxide sterilization 28-0023 CHROMATE PIGMENT, potential carcinogen 31-0034 CHROMATE PIGMENTS, cause of death from lung cancer in workers exposed to 31-0035 CHROMATE PIGMENTS, potential carcinogen and lung carcinogen for workers 27-0029 CHROMATE WASTES, potential health hazard to Japanese citizens 27-0030 CHROMATES, carcinogenic effect noted in Italian studies and Norwegian industry 27-0030 CHROMATES, NIOSH may issue potential carcinogen alert 27-0029 CHROMATES, potential carcinogens 27-0028 CHROMIC OXIDE PIGMENT, apparently non-toxic and non-carcinogenic when fed to rats 47-0031 CHROMIUM, potential carcinogenicity of Cr(VI) compounds 36-0001 CHROMIUM COMPOUNDS, carcinogenic to man 38-0001 CHRYSOTILE ASBESTOS, environmental health hazards can be eliminated if proper controls are used 38-0001 CHRYSOTILE ASBESTOS, increasing consumption indicates its essential contribution to many Industrial products 46-0056 CINNAMYLPHENOLS, newly synthesized compounds show promise as safe blocides 31-0032 CLEAN-AIR REGULATIONS, economic impact on the chemical process industry 30-0024 COAL, court decision re: need for environmental impact statements slows mining operations 50-0016 COAL, major direct combustion projects 32-0037 COAL CHAR, potential source of environmentally-clean electricity 31-0022 COAL CONVERSION, environmental aspects 46-0029 COAL CONVERSION, four basic methods for deriving oil or gas from coal 35-0017 COAL CONVERSION, funding by state of Illinois spurs activity in coal conversion demonstration plants 46-0028 COAL CONVERSION, higher natural gas prices plus better availability of coal and Increasing use of oil and gas for petrochemicals spur research and development 35-0017 COAL CONVERSION, legislative and financial problems seen as greatest impediments to development of a U.S. coal conversion industry 31-0023 COAL CONVERSION, methods and uses 38-0017 COAL CONVERSION, potential cause of cancer because of air pollution 48-0019 COAL CONVERSION, potential wastewater pollutants 50-0016 COAL CONVERSION, research and development amounting to more than $400 million 48-0020 COAL CONVERSION, research program by ERDA designed for speedy development of necessary technology with minimal Impact on the environment 50-0016 COAL CONVERSION AND UTILIZATION PROGRAM, EHDA developing technology for commercialization of processes 49-0019 COAL CONVERSION LIQUIDS, mutagenic tests on 49-0019 COAL CONVERSION LIQUIDS, toxicity tests on 50-0016 COAL CONVERSION PROCESSES, status of demonstration plants 36-0016 COAL GASIFICATION, catalysts 50-0018 COAL GASIFICATION, Commonwealth Edison's multimillion dollar project 36-0016 COAL GASIFICATION, direct production of methane from coal-steam reactions 38-0015 COAL GASIFICATION, economic and environmental criteria compared for three processes 30-0023 COAL GASIFICATION, economics 36-0015 COAL GASIFICATION, electrofluid reactors 30-0026 COAL GASIFICATION, environmental considerations in retrofitting existing processes 45-0021 COAL GASIFICATION, federal financing of plants 36-0015 COAL GASIFICATION, fluidized bed processors 50-0016 COAL GASIFICATION, major high and low B.t.u. projects outlined 33-0015 COAL GASIFICATION, new unit offered by Riley Stoker's Riley division 52-0024 COAL GASIFICATION, North Dakota waits for Impact study 51-0016 COAL GASIFICATION, pilot plant for Synthane Process 46-0030 COAL GASIFICATION, plant economics 30-0025 COAL GASIFICATION, potential environmental effect of BuMlne's Synthane Process 30-0027 COAL GASIFICATION, potential environmental effects of Lurgi process 52-0023 COAL GASIFICATION, process demonstration 48-0022 COAL GASIFICATION, system under development for OCR by Combustion Engineering, Inc., is In final design stage 38-0016 COAL GASIFICATION, technology and environmental effects 27-0012 COAL GASIFICATION AND LIQUEFACTION, review of technologies 43-0018 COAL GASIFICATION AND LIQUEFACTION, two experimental projects in U.S. and Scotland are making progress 42-0017 COAL HYDROGENATION, advocated for production of liquid fuels for the transportation market 50-0017 COAL LIQUEFACTION, Arthur D. Little, Inc. process 49-0019 COAL LIQUEFACTION, chemical-biological characterization conversion liquids 52-0025 COAL LIQUEFACTION, demonstration plant by Fluor Engineers 52-0022 COAL LIQUEFACTION, demonstration plant by Occidental Research 33-0016 COAL LIQUEFACTION, environmental factors 42-0018 COAL LIQUEFACTION, ERDA plans to give $5 million in contracts to three companies to determine technical and economic feasibility of their proposed methods -11- ------- Ref. No. 38-0013 COAL LIQUEFACTION, Exxon Donor Solvent (EDS) Process is working well in pilot plant runs 28-0013 COAL LIQUEFACTION, flash hydrogenation of coal provides high liquid yield 50-0016 COAL LIQUEFACTION, major projects outlined 38-0014 COAL LIQUEFACTION, New Athens, Illinois, site of planned Coalcon demonstration plant selected because of freedom from environmental site problems 48-0021 COAL LIQUEFACTION, new Clean Fuel from Coal process applicable to most domestic coals 51-0015 COAL LIQUEFACTION, process development 28-0014 COAL LIQUEFACTION, pros and cons of various processes under development COAL LIQUEFACTION AND GASIFICATION, see: coal gasification and liquefaction 48-0041 COAL-TAR PITCH, potential hazards of fumes 29-0027 COKE OVEN WORKERS, high death rate from lung cancer 34-0012 COKE OVENS, benzo(a)pyrene emissions labelled as cause of cancer 44-0023 CYCLOHEXANONE, potential health hazard In PVC extruded hose manufacture 51-0028 CYCLOTRIMETHYLENETRINITRAMINE, acute and chronic biochemical and behavioral effects of 35-0048 DDT, bottom fish near contaminated sediments still show high levels of the pesticide indicating potential food hazards . 27-0007 N,N'-DIACETYLBENZIDINE, potential cause of kidney damage in rats 36-0021 DIALLYPHTHALATE MONOMERS AND POLYMERS, FMC increases price of 41-0017 4,4'-DIAMINODIPHENYLMETHANE, potential cause of toxic hepatitis and potential carcinogen 38-0007 DIBENZYLNITROSAMINE, mutagenic potency 36-0007 DIBROMOCHLOROMETHANE, National Organics Reconnaissance Survey for halogenated organics 31-0008 2,3-DIBROMOPROPYL ACRYLATE, new flame retardant for coatings and plastics 31-0008 2,3-DIBROMOPROPYL METHACRYLATE, new flame retardant for coatings and plastics 43-0010 DIBROMOPROPYL PHOSPHATE, flame retardant In children's sleepwear cited as potential carcinogen 49-0031 DIBUTYLNITROSAMINE, effect on dimethylnitrosamine metabolism and toxicity 38-0007 DI-N-BUTYLNITROSAM1NE, mutagenic potency 30-0034 DIBUTYL PHTHALATE, retention and excretion in rats 30-0033 DIBUTYL PHTHALATE, toxlcological properties in rats 42-0004 DICHLOROBENZIDINE, colorimetric assay for detection in urine and water 31-0006 3,3'-DICHLOROBENZIDINE, environmental fate 33-0008 3,3'-DICHLOROBENZIDINE, if carcinogenic to humans is weaker than benzidlne 33-0008' 3,3'-DICHLOROBENZIDINE, non-potential human carcinogen 35-0014 trans-l,4-DICHLOROBUTEHE-2Vcarcinogenicity in mice 37-0012 DICHLORODIFLUOROMETHANE, atmospheric concentrations 37-0016 DICHLORODIFLUOROMETHANE, concentrations in atmosphere measured by infrared •37-0011 DICHLORODIFLUOROMETHANE, distribution and fate in animals inhaling 36-0008 DICHLORODIFLUOROMETHANE, effects on tracheobronchial particle deposition and clearance in donkeys 40-0008 DICHLORODIFLOUROMETHANE, estimated stratospheric concentration of gaseous chlorine compounds 30-0016 DICHLORODIFLUOROMETHANE, interactions with human and bovine globulins 40-0009 DICHLORODIFLUOROMETHANE, stratospheric concentrations 40-0011 DICHLORODIFLUOROMETHANE, stratospheric profile 31-0012 DICHLORODIFLUOROMETHANE, ultraviolet photoabsorption 46-0017 DICHLORODIFLUOROMETHANE (FC-12), world production from start of commercial manufacture through 1975 set at 11,197.million Ib 41-0013 DICHLORODIPHENYL, absorption, transport, and organotropism in rat compared to that of hexachlorobenzene 36-0010 DICHLOROETHANE, monitoring with a portable mass spectrometer 36-0007 1,2-DICHLORETHANE, National Organics Reconnaissance Survey for halogenated organics 35-0019 1,1-DICHLOROETHYLENE, mutagenicity 35-0019 cis-l,2-DICHLOROETHYLENE, mutagenicity 35-0019 trans-l,2-DICHLORpETHYLENE, mutagenicity 46-0001 DICHLOROETHYL ETHER, among several chemicals for which NIOSH plans to develop recommended standards for occupational exposure to by 1979 •42-0010 DICHLOROFLUOROMETHANE, adsorption on activated carbon 30-0015 DICHLOROFLUOROMETHANE, solubility in blood and plasma of different species 36-0010 DICHLOROMETHANE, monitoring with a portable mass spectrometer 36-0010 DICHLOROMONOFLUOROMETHANE, monitoring with a portable mass spectrometer 42-0010 DICHLOROTETRAFLUOROETHANE, adsorption on activated carbon 42-0011 DICHLOROTETRAFLUOROETHANE, biological half-life 30-0016 DICHLOROTETRAFLUOROETHANE, Interactions with human and bovine globulins 42-0011 DICHLOROrETRAFLUOROETHANE, pharmacokinetics in dogs 30-0015 DICHLOROTETRAFLUOROETHANE, solubility in blood and plasma of different species 41-0013 DIELDR1N, absorption, transport, and organotropism in rat compared to that of hexachlorobenzene 31-0025 DI-(2-ETHYLHEXYL) PHTHALATE, absorption, metabolism, and tissue distribution in rats 46-0032 DI-(2-ETHYLHEXYL) PHTHALATE, acute and chronic toxlcities of 33-0022 DI-(2-ETHYLHEXYL) PHTHALATE, detection in air 38-0022 DI-(2-ETHYLHEXYL) PHTHALATE, detection in environmental samples 33-0023 DI-C2-ETHYLHEXYL) PHTHALATE, detection in open-ocean biota samples 31-0026 DI-(2-ETHYLHEXYL) PHTHALATE, dietary influence on lipid metabolism 44-0023 DI-(2-ETHYLHEXYL) PHTHALATE, potential health hazard in PVC extruded hose manufacture 46-0033 DI-(2-ETHYLHEXYL) PHTHALATE, toxicology of in devices in contact with blood 39-0019 DI-(2-ETHYLHEXYL) PHTHALATE, toxicology of plastic devices in contact with blood 47-0029 DIETHYLNITROSAMINE, biological activity of principal product from reaction in the Udenfrlend system 35*0044 DIETHYLNITROSAMINE, carcinogenic and cocarclnogenic effects (with synthetic smog and ferric oxide particles) of inhalation on Syrian hamsters 37-0037 DIETHYLNITROSAMINE, carcinogenic and mutagenic effects 47-0028 DIETHYLNITROSAMINE, carcinogenic effects on Chinese hamsters 35-0041 DIETHYLNITROSAMINE, carcinogenic effects on fetal respiratory tract of Syrian hamsters 40-0032 DIETHYLNITROSAMINE, effect of serum on growth of precancerous foci and tumors induced by DENA 49-0031 DIETHYLNITROSAMINE, effect on dimethylnitrosamine metabolism and toxicity 46-0047 DIETHYLNITROSAMINE, effect on intrasplenic tumor formation in hamsters 46-0046 DIETHYLNITROSAMINE, effects in combination with cigarette smoke on hamsters 46-0046 DIETHYLNITROSAMINE, effects on hamsters -12- ------- Ref. No. 35-0039 DIETHYLNITROSAMINE, factors affecting metabolism and mutagenicity 48-0006 DIETHYLNITROSAMINE, inhalation effects on hamsters exposed to cigarette smoke 40-0029 DIETHYLNITROSAMINE, lung and stomach tumors induced in mice 38-0008 DIETHYLNITROSAMINE, mutagenic potency 47-0029 DIETHYLNITROSAMINE, mutagenic studies 40-0029 DIETHYLNITROSAMINE, plasma esterase changes in mice 48-0006 DIETHYLNITROSAMINE, potential cocarcinogen 41-0032 DIETHYLNITROSAMINE, renal carcinogenlcity modification by actinomycin D and a protein deficient diet 47-0030 DIETHYLNITROSAMINE, respiratory carcinogenic effects on hamsters when given alone or with ferric oxide 35-0041 DIETHYLNITROSAMINE, transplacental carcinogenic effect In Syrian hamsters related to time of administration during pregnancy 29-0025 DIETHYLSTILBESTROL, potential carcinogen may be banned in animal feeding 36-0008 DIFLUORODICHLOROMETHANE, effects on tracheobronchial particle deposition and clearance in donkeys 37-0010 DIFLUORODICHLOROMETHANE, metabolic effects in various animals 36-0023 DIISOCYANATES, hydrolytic stability of 36-0022 DIISODECYL PHTHALATE, BASF Wyandotte increases price of 50-0024 DIMETHYLCARBAMOYL CHLORIDE (DMCC), acute toxic effects and carcinogenic potential 48-0012 DIMETHYLCARBOMOYL CHLORIDE, Inducer of rare squamous cell (skin) cancer of the nose in rats 45-0036 DIMETHYLCARBOMOYL CHLORIDE, possible carcinogen 48-0012 DIMETHYLCARBOMOYL CHLORIDE, potential Inhalation carcinogen in rats 38-0041 2,2'-DIMETHYLDIPROPYLNITROSAMINE, carcinogenic effects in hamsters 40-0015 DIMETHYLHYDRAZINE, effect on rabbit pancreas 35-0016 1,1-DIMETHYLHYDRAZINE, effect on sperm abnormalities in mice 49-0016 1,1-DIMETHYLHYDRAZINE, effects on guinea pigs 49-0016 1,1-DIMETHYLHYDRAZINE, immunologlcal response in guinea pigs following exposure to 48-0017 1,1-DIMETHYLHYDRAZINE, teratogenic effects on embryos of the South African clawed toad 32-0011 1,2-DIMETHYLHYDRAZINE, iumunologlc aspects of colon tumors Induced in rats 38-0007 1,2-DIMETHYLHYDRAZINE, mutagenic potency 48-0017 1,2-DIMETHYLHYDRAZINE, teratogenic effects on embryos of the South African clawed toad 42-0014 1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE, most potent carcinogen in mice of six methylated hydrazines tested 49-0034 DIMETHYLNITROSAMINE, age-dependence of DMN-demethylase activity in the rat 41-0031 DIMETHYLNITROSAMINE, carcinogenic action on livers of rats after partial hepatectomy 37-0037 DIMETHYLNITROSAMINE, carcinogenic and mutagenic effects 47-0028 DIMETHYLNITROSAMINE, carcinogenic effects on Chinese hamsters 38-0040 DIMETHYLNITROSAMINE, correlation between carcinogenicity and mutagenicity In mice 36-0013 DIMETHYLNITROSAMINE (DMNA), detectable quantities threaten closing of FMC unsymmetrical dlmethylhydrazine plant 35-0037 DIMETHYLNITROSAMINE, detection of 12 ppb in air near FMC's Baltimore rocket fuel plant may force closing of plant 37-0036 DIMETHYLNITROSAMINE, DNA damage In mouse organs 40-0028 DIMETHYLNITROSAMINE, effect on organ cultures of human embryonic lung and kidney tissues 35-0016 DIMETHYLNITROSAMINE, effect on sperm abnormalities in mice 35-0039 DIMETHYLNITROSAMINE, factors affecting metabolism and mutagenicity 38-0039 DIMETHYLNITROSAMINE, inhalation of 1 to 1.4 ug possible from levels existing in air in certain area 48-0037 DIMETHYLNITROSAMINE, inhibition of rat liver RNA polymerases 39-0028 DIMETHYLNITROSAMINE, lethal effect on bacteria 38-0042 DIMETHYLNITROSAMINE, metabolism and acute toxicity in rata 49-0032 DIMETHYLNITROSAMINE, methods for limiting content in marine salt fish 37-0039 DIMETHYLNITROSAMINE, mutagenic effects in rat 38-0007 DIMETHYLNITROSAMINE, mutagenic potency 49-0036 DIMETHYLNITROSAMINE, part per billion concentration levels detected in air of several U.S. cities 35-0037 DIMETHYLNITROSAMINE, potential carcinogen detected in Baltimore air 30-0045 DIMETHYLNITROSAMINE, presence in urban air instigates EPA air and water studies 38-0043 DIMETHYLNITROSAMINE, presence in various cured Jellied products 37-0023 DIMETHYLNITROSAMINE, presence of this suspect carcinogen in air causes closing of rocket fuel plant 41-0029 DIMETHYLNITROSAMINE, test compound In studies that show that analysis of alkylated amino acids in haemoglobin can be used clinically to obtain risk estimates for humans exposed to genotoxic agents 36-0014 DIMETHYLNITROSAMINE, toxic Intermediate in the processing of unsymmetrical dimethyIhydrazlne causes FMC plant shut down 40-0030 DIMETHYLNITROSAMINE-DEMETHYLASE, repression by polynuclear hydrocarbons and nonhydrocarbon compounds 28-0016 DIMETHYL TEREPHTHALATE, its absorption, distribution and excretion in rabbits and rats 28-0016 DIMETHYL TEREPHTHALATE, potential health hazards 46-0032 DI-n-OCTYL PHTHALATE, acute and chronic toxicitles of 40-0017 DI-n-OCTYL PHTHALATE, distribution in various organisms 40-0017 DI-n-OCTYL PHTHALATE, fate in two model ecosystems 36-0020 DIOCTYL PHTHALATE, aerosol generator of high stability 48-0002 DIOCTYL PHTHALATE, production drop in 1975 30-0033 DIOCTYL PHTHALATE, lexicological properties in rats 52-0012 DIOXANE, effect on liver and drug metabolism 30-0009 DIOXANE, occupational hazards and control 36-0004 DIOXANE, OSHA draft technical standards 42-0006 . DIOXANE-BASED HERBICIDE, evaluation study underway at FMC to determine feasibility of commercializing new pre-emergence herbicide 38-0007 DI-n-PENTYLNITROSAMINE, mutagenic potency 38-0007 DIPHENYLNITROSAMINE, mutagenic potency 38-0041 DI-n-PROPYLNITROSAMINE, carcinogen effects in animala 38-0007 DI-n-PROPYLNITROSAMINE, mutagenic potency -13- ------- Ref. No. 34-0013 EARTHWORMS, potential monitors of heavy metals In sewage sludge 39-0015 ECOLOGICAL MODELING, problems and prospects of use 43-0021 ECOLOGY, mercury-resistant and mercury-metabolizing bacteria In Chesapeake Bay 43-0023 ECOLOGY, water pollution by Insecticides (a bibliography with abstracts) 43-0024 43-0019 ECOSYSTEM ANALYSIS, environmental contamination by lead 39-0014 ECOSYSTEM M3DELS, bibliography 38-0018 ECOSYSTEMS, analysis and prediction 39-0013 ECOSYSTEMS, bio-refractory index for organics In water 33-0018 ECOSYSTEMS, effect on human food chain of cadmium-containing sewage sludge used as fertilizer 49-0021 ECOSYSTEMS, evaluation of microcosms as means of predicting chemical fate in natural ecosystems 36-0017 ECOSYSTEMS, modeling the dynamics of biological and chemical components of aquatic 36-0018 ECOSYSTEMS, path of pollutants 33-0017 ECOSYSTEMS, productivity 32-0037 ELECTRICITY, non-polluting process for production from low-grade coal or char residue from coal liquefaction 30-0042 ENDOTHAL, uptake, distribution and accumulation in fish 41-0039 ENERGY, Ocean Thermal Energy Conversion (OTEC) may be new source of 39-0033 ENERGY, Ocean Thermal Energy Conversion proposes use of the sea as a heat source and heat sink for generating electricity 42-0017 ENERGY, review of alternatives for petroleum and natural gas 41-0040 ENERGY, six ocean energy sources (tides, waves, salinity gradients, currents, winds, and bioconversion) are added to ocean thermal energy conversion as potential means of exploiting energy from oceans 38-0045 ENERGY CONSERVATION, solar collectors for buildings 39-0039 ENVIRONMENTAL CARCINOGENS, bibliography 42-0033 ETHYLENE, long-term Inhalation studies on rats to be conducted 38-0036 ETHYLENE, new alkylation catalyst offers advantage of an environmentally clean production process 38-0035 ETHYLENE, new economics stemming from possible use of heavier feedstocks must relate to consuming products, such as polyvinyl chloride 40-0027 ETHYLENE DIBROMIDE, effect on automobile catalytic converters for removal of air pollutants 50-0023 ETHYLENE DIBROMDE, leak stopped and potential hazard avoided 38-0038 ETHYLENE DIBROMIDE, low residues in apples fumigated with 42-0026 ETHYLENE DIBROMIDE, mutagenic effect on clones of Tradescantl 38-0007 ETHYLENE DIBROMIDE, mutagenic potency 38-0038 ETHYLENE DIBROMIDE, potential carcinogen in rats and mice 39-0027 ETHYLENE DIBROMIDE, potential carcinogen not seen as significant health hazard on basis of amounts detected in air and water 39-0027 ETHYLENE DIBROMIDE, sampling and analysis in air and water 46-0031 ETHYLENE DICHLORIDE, NIOSH has proposed an occupational exposure standard with a 5 ppm limit 31-0006 ETHYLENEIMINE, environmental fate 28-0024 ETHYLENEIMINE, one of 13 carcinogens for which OSHA has published health standards 41-0009 ETHYLENEIMINE, methods of scoring induced chromosome structural changes in barley 49-0010 ETHYLENEIMINE, mutagenic effects of 38-0007 ETHYLENEIMINE, mutagenic potency 39-0016 0-ETHYL 0-[4-(METHYLTHIO) PHENYL] S-PROPYL PHOSPHORODITHIOATE, metabolism by cow 39-0017 0-ETHYL 0-[4-(METHYLTHIO) PHENYL] S-PROPYL PHOSPHORODITHIOATE, metabolism by rats 36-0008 FC 11, effects on tracheobronchial particle deposition and clearance in donkeys 36-0008 FC 12, effects on tracheobronchial particle deposition and clearance in donkeys 35-0044 FERRIC OXIDE, carcinogenic and cocarcinogenlc effects of inhalation on Syrian hamsters 35-0008 FIRE-RETARDANT ADDITIVES, Diamond Shamrock Corp.'s Houston, Texas plant scheduled for 1977 opening 29-0006 FIRE-RETARDANT FABRICS, contamination with glycerine, hand lotions and baby oil counteracts fire retardancy 49-0012 FIRE RETARDANTS, proceedings of international symposium now available 36-0006 FIRE STOP, a tetrakls hydroxymethyl phosphonium chloride (THPC)- derived finish 42-0007 FLAME RETARDANT, absorption of tris (2,3-dlbromylpropyl) phosphate from treated fabric 43-0008 FLAME RETARDANTS, carpets and rugs captured about 75% of 1975 market 29-0006 FLAME RETARDANTS, contamination of treated fabrics with glycerine, hand lotions and baby oil affects fabric flame resistance 41-0010 FLAME RETARDANTS, environmental chemistry 47-0010 FLAME RETARDANTS, expanded facilities at Michigan Chemical Corporation's El Dorado, Arkansas facilities will be use to increase production of fireMaster 680 and other flame retardants 30-0011 FLAME RETARDANTS, fibers and textiles 36-0005 FLAME RETARDANTS, foreign organic fire resistant polymers 30-0010 FLAME RETARDANTS, intumescent coatings may cut into market for plastics 29-0005 FLAME RETARDANTS, intumescent coatings on plastics reduce smoke evolution 41-0008 FLAME RETARDANTS, major component of a polybrominated biphenyl industrial product indentlfied 43-0008 FLAME RETARDANTS, market demand may soar to about 500 million Ib/year by 1980 30-0010 FLAME RETARDANTS, market potential in plastics 35-0009 FLAME RETARDANTS, Mobil Chemical plans to be onstream in 1977 with new trimethyl phosphite plant in Charleston, S.C. 31-0008 FLAME RETARDANTS, new brominated acrylic monomers available from Great Lakes Chemical Corp. 47-0011 FLAME RETARDANTS, new non-toxic water soluble complex phosphonate ester (Poly-Card 123) for polyesters is now offered by Hamilton-Auelander Mfg. Co. for children's sleepwear, household fabrics, and camping equipment 45-0010 FLAME RETARDANTS, new plant planned by Michigan Chemical 31-0010 FLAME RETARDANTS, new phosphoramlde derivatives are effective for cottons 30-0010 FLAME RETARDANTS, new products still based on bromine, phosphorus, and antimony oxide 27-0008 FLAME RETARDANTS, new vinyl chloride-containing terpolymer for molding and extrusion applications 45-0011 FLAME RETARDANTS, Olin Chemicals new plant for production -14- ------- Ret. No. 33-0009 FLAME RETARDANTS, planned additional capacity for trimethyl phosphite by Mobil Chemical will be used in part to manufacture PR's 45-0008 FLAME RETARDANTS, potential carcinogenics 48-0009 FLAME RETARDANTS, potential environmental hazards review 41-0007 FLAME RETARDANTS, potential toxicity and teratogenlclty in rodents of a commercial polybromlnated biphenyl product 49-0011 FLAME RETARDANTS, report on symposium 31-0009 FLAME RETARDANTS, special formulation for polyester/cotton blends 45-0007 FLAME RETARDANTS, sterility induced by 45-0009 FLAME RETARDANTS, symposium 45-0006 FLAME RETARDANTS, toxic effects 38-0008 FLAME RETARDANTS, toxicity to goldfish 36-0006 FLAME RETARDANTS, UM & M's all-cotton children's sleepwear fabric finished with Fire Stop, a tetrakis hydroxymethyl phosphonium chloride (THPC) derived finish 35-0010 FLAME RETARDANTS, use In fighting forest fires estimated at over 20 million gal/yr 49-0012 FLAMMABILITY, proceedings of international symposium now available 27-0016 FLUORESCENT WHITENING AGENTS, accumulation In fish tissue not significant 27-0017 FLUORESCENT WHITENING AGENTS, non-phototoxic and non-contributing to photocarcinogenesis in skin tests on mice 37-0025 FLUORESCENT WHITENING AGENTS, not likely to enter groundwater supplies via rainwater leaching of detergent sludge 27-0017 FLUORESCENT WHITENING AGENTS, photocarcinogenesis studies on mouse skin 27-0018 FLUORESCENT WHITENING AGENTS, phototoxicity and photocarcinogenicity on mouse skin 27-0019 37-0025 FLUORESCENT WHITENING AGENTS, removal from wastewater 27-0016 FLUORESCENT WHITENING AGENTS, toxicity in fish 34-0015 FLUORIDES, NCI concludes water fluoridation not cause of cancer 40-0010 FLUORINE, photochemistry in the stratosphere 36-0009 FLUOROCARBON BAN, effects of 27-0010 FLUOROCARBON BAN would affect carbon tetrachloride market 28-0012 FLUOROCARBON PROPELLANTS, FDA orders companies to submit drug product information 28-0007 FLUOROCARBON PROPELLANTS, potential corrosion of aerosol containers limits use In oven cleaner formulations 42-0010 FLUOROCARBONS, adsorption on activated carbon 47-0016 FLUOROCARBONS, aerosol production In free world exclusive of United States and Canada climbed by 14* in 1974 over 1973 production 46-0016 FLUOROCARBONS, Allied Chemical and Du Font are working to develop stratospherlcally safe fluorocarbons pending possible -government ban on use of trichloromono- and dichlorodlfluoromethane 31-0017 FLUOROCARBONS, alternative propellants for F-ll and F-12 include F-21 and F-22 37-0019 FLUOROCARBONS, ammonia-HCl sink for chlorine is ruled out 46-0017 FLUOROCARBONS, annual and cumulative production and sales data from start of commercial production through 1975 now available from MCA 34-0004 FLUOROCARBONS, atmospheric concentration 30-0012 FLUOROCARBONS, atmospheric concentration effects on world's temperature 40-0018 FLUOROCARBONS, blowing agents for new polyurethane foam in aerosol can dispenser 31-0011 FLUOROCARBONS, breakdown by sunlight in upper atmosphere 40-0013 FLUOROCARBONS, British researchers find evidence of possible 10% depletion of ozone layer but anticipate allowing 10 years before restricting manufacture of some fluorocarbons 48-0011 FLUOROCARBONS, British researchers support theory that chlorine nitrate reduces stratospheric ozone loss 35-0011 FLUOROCARBONS, comparison of distribution of F-ll and krypton-85 in atmosphere may shed light on stratospheric ozone depletion problem 47-0013 FLUOROCARBONS, confusion regarding effects on ozone layer 43-0013 FLUOROCARBONS, correlation between aerosol usage and respiratory symptoms in humans 37-0017 FLUOROCARBONS, CPSC rejects petition to ban use in aerosol products 46-0019 FLUOROCARBONS, decreased U.S. production of aerosols due to ozone controversy is expected to recover by 1980 despite new theory of persistence of chlorine nitrates In stratosphere acting as a sink for liberated chlorine Rowland and Molina are pushing for fluorocarbon ban FLUOROCARBONS, distribution and fate of Inhaled compounds in animals FLUOROCARBONS, drawbacks of alternative propellants such as C02 or hydrocarbons may be lessened by addition of methylene chloride FLUOROCARBONS, drop of 14X In 1975 U.S. aerosol production compared to 1974 is blamed on general economic conditions as well as the ozone depletion controversy FLUOROCARBONS, economic impacts of bans on their use FLUOROCARBONS, effect of F-ll on preexisting heart disease 47-0014 FLUOROCARBONS, 37-0011 40-0014 47-0017 39-0009 45-0014 45-0017 45-0014 45-0018 45-0014 31-0011 31-0019 37-0017 40-0008 35-0012 31-0017 47-0013 FLUOROCARBONS, FLUOROCARBONS, FLUOROCARBONS, FLUOROCARBONS, FLUOROCARBONS, 42-0008 FLUOROCARBONS, FLUOROCARBONS, FLUOROCARBONS, FLUOROCARBONS, FLUOROCARBONS, FLUOROCARBONS, 46-0015 FLUOROCARBONS, effect of F-1301 on preexisting heart disease effect on ozone layer depletion overestimated effect on preexisting heart disease effects of temperature on breakdown In stratosphere eight states enact or propose to enact legislation to control or ban sales of aerosol propellants electron capture gas chromatography as possible means of determining oceanic concentrations of halogenated compounds EFA urges use of alternatives in aerosol pesticides estimated stratospheric concentration of gaseous chlorine compounds expected Alaskan volcano eruption may provide test of stratospheric ozone depletion theory F-22 seen as less toxic than F-ll and F-12 aerosol propellants formation of chlorine nitrate may tie up chlorine liberated from fluorocarbons and cut down amount of ozone destroyed Government may act by end of 1976 to ban fluorocarbon propellants giving industry a two-or-three year deadline -15- ------- Rof. No. 43-0012 FLUOROCARBONS, harmful biological effects predicted by ozone depletion theories seen as premature and misleading 47-0015 FLUOROCARBONS, in midst of continuing confirmations and contradictions on the ozone depletion theory the U.S. consumer continues to purchase aerosol products 47-0017 FLUOROCARBONS, increase of about 20% in production over 1975 figures is anticipated for 1976 46-0019 FLUORQCARBONS, industry is working on safe nonchlorofluorocarbons for aerosols 37-0016 FLUOROCARBONS, infrared measurement in atmosphere 48-0010 FLUOROCARBONS, insufficient measurements on past ozone levels cast doubts on man's ability to permanently modify the ozone layer 30-0016 FLUOROCARBONS, interactions with human and bovine globulins 30-0015 FLUOROCARBONS, interspecies differences may be factor in extrapolating animal data to predict human toxiclty 28-0008 FLUOROCARBONS, Kaiser booklet presents overview of fluorocarbon/ozone controversy 44-0014 FLUOROCARBONS, Kentucky producers and users fight proposed state ban citing economic and scientific reasons 31-0014 FLUOROCARBONS, malodors in propellent containing F-ll and 12 blended with nitromethane 31-0016 FLUOROCARBONS, mathematical computer simulates ozone region to study effects of 33-0012 FLUOROCARBONS, measurement of erythemally effective UV radiation and total ozone content 29-0008 FLUOROCARBONS, measurement of F-ll and F-12 In lower stratosphere confirms increased concentration from production and use 37-0010 FLUOROCARBONS, metabolic effects in various animals 43-0014 FLUOROCARBONS, mortality survey of pesticides including aerosols 47-0012 FLUOROCARBONS, NAS report on damage to ozone layer delayed 50-0009 FLUOROCARBONS, National Bureau of Standards Conference on ozone 36-0007 FLUOROCARBONS, National Organics Reconnaissance Survey for halogenated Organlcs 33-0010 FLUOROCARBONS, NBS researchers report lower value for rate of reaction between chlorine and ozone 35-0013 FLUOROCARBONS, new calculations with F-12 and F-ll show temperature differences in stratosphere versus room temperature do not effectively change ozone depletion theory 33-0011 FLUOROCARBONS, new C02 value/glass container system offers competition to fluorocarbon propellants in aerosol fragrances market 27-0009 FLUOROCARBONS, new data implicates them as potential health hazards 47-0013 FLUOROCARBONS, new data indicate only minor temperature changes from ozone depletion 37-0018 FLUOROCARBONS, new rate data for ozone depletion reaction 37-0019 FLUOROCARBONS, new rate data refines ozone-depletion theory 43-0011 FLUOROCARBONS, new studies up by 10% the possibility of skin cancer cases possible from a 102 destruction of stratospheric ozone 31-0017 FLUOROCARBONS, ozone controversy slows European aerosol market 30-0017 FLUOROCARBONS, ozone damage potential may be less than that resulting from chlorination of water 28-0011 FLUOROCARBONS, ozone theory criticized on several scores 28-0009 FLUOROCARBONS, Packaging Institute seminar airs science/industry approach to fluorocarbon/ ozone controversy 46-0013 FLUOROCARBONS, photoelectron and far-u.v. absorption spectra 27-0009 FLUOROCARBONS, potential cause of cardiac arrhythmia and death 30-0013 FLUOROCARBONS, potential toxic thermal decomposition products 46-0018 FLUOROCARBONS, production of aerosols in free world outside U.S. and Canada (except in Japan) rose 14Z over 1973 30-0020 FLUOROCARBONS, properties, uses and environmental effects 49-0013 FLUOROCARBONS, proposed classification scheme for toxlcity of 30-0019 FLUOROCARBONS, proposed Wisconsin bill may upset state's economy 45-0012 FLUOROCARBONS, reproductive and teratologic effects on rats 46-0016 FLUOROCARBONS, research on hydrocarbons and dimethyl-ethers as alternative propellants supported by Japanese fluorocarbon producers 45-0016 FLUOROCARBONS, residence times in atmosphere based on reactivity 36-0012 FLUOROCARBONS, restricted use in aerosol spray cans passed by N.Y. Legislature 29-0009 FLUOROCARBONS, role in ozone depletion debated 31-0018 FLUOROCARBONS, seven new research contracts covering effects on Earth's atmosphere brings current research funding to $l.l-mlllion 30-0015 FLUOROCARBONS, solubilities in blood and plasma of different species 52-0013 FLUOROCARBONS, stratospheric chlorSne nitrate from 45-0013 FLUOROCARBONS, stratospheric concentrations of 46-0022 FLUOROCARBONS, stratospheric-Ion chemistry relative to 11-year variation in polar ozone 46-0023 FLUOROCARBONS, stratospheric ozone effects on temperature 44-0013 FLUOROCARBONS, study sponsored by Precision Valve Corp. indicated uncertainties in ozone depletion theory 30-0014 FLUOROCARBONS, thermal decomposition products not considered hazard under normal use 30-0019 FLUOROCARBONS, tonnage reaching atmosphere each year is far beyond amount that the atmosphere can absorb 41-0011 FLUOROCARBONS, tropospheric-stratospheric feedback calculations recommended for future models calculating potential stratospheric ozone loss 31-0012 FLUOROCARBONS, ultraviolet photoabsorption 45-0015 FLUOROCARBONS, use as substitute surgical cleanser 30-0019 FLUOROCARBONS, Wisconsin bill proposes banning sales of aerosols by 1980 36-0008 FLUOROCARBONS 11 AND 12, effects on tracheobronchial particle deposition and clearance In donkeys 44-0013 • FLUOROCARBONS 11 AND 12, much less significant contributors to atmospheric chlorine than carbon tetrachlorlde 51-0006 FLUOROCARBONS/OZONE, airborne research laboratory 30-0018 FLUOROCARBONS/OZONE, effect of temperature on breakdown of fluorocarbons by UV light adds new scope to controversy 51-0008 FLUOROCARBONS/OZONE, industry research 51-0007 FLUOROCARBONS/OZONE, laboratory study 46-0034 FLUOROPOLYURETHANES, use In liquid epoxy resins to prevent marine borer attack on wood 36-0008 FLUOR01RICHLOROMETHANE, effects on tracheobronchial particle deposition and clearance in donkeys -16- ------- Ref. No. 31-0037 FORMALDEHYDE, potential inhalation health hazard 27-0025 ' FORMALDEHYDE AND OTHER CHEMICALS USED IN PLASTICS, decreased 1975 demand should turn around in 1976 but still fall short of 197A levels 27-0024 FORMALDEHYDE AND OTHER ORGANIC CHEMICALS, mid-1975 production was well below mid-1974 output 45-0015 FREON, use as substitute surgical cleanser 35-0020 FUEL ADDITIVE, Ashland Oil announces new compound identified as AMD-4 45-0020 30-0047 GASIFICATION OF COAL, economical in situ technique GASOLINE, decreased sale period coincides with reduced mortality rates 40-0036 HAIR DYES, potential mutagenic and carcinogenic hazards for hairdressers and workers in cosmetic manufacturing plants 37-0014 HALOCARBONS, analysis in atmosphere by gas chromatography-mass spectrometry 34-0004 HALOCARBONS, atmospheric concentration 46-0014 HALOCARBONS, formation in tropospheric air judged due to direct emissions of chemicals 46-0021 HALOCARBONS, inorganic and organic components of tropospheric halogen gases 37-0015 HALOCARBONS, natural compounds in air and sea 45-0013 HALOCARBONS, stratospheric concentrations of 34-0004 HALOCARBONS, useful tracers of atmospheric transport 52-0014 HALOETHERS, in the atmosphere from textile finishing 52-0015 HALOETHERS, lung cancer following worker exposure 29-0004 HALOETHERS, potential environmental contaminants in river waters 35-0014 HALOETHERS, toxicity in mice 52-0040 HALOGENATED HYDROCARBON GASES, toxicologlcal studies on 52-0040 HALOGENATED HYDROCARBON GASES, used as fire extinguishers, anesthetics, solvents, pesticides and aerosol propellents 30-0017 HALOGENATED HYDROCARBONS, volatile products from chlorination of water may cause atmospheric ozone depletion 52-0040 HALOGENATED ORGANIC COMPOUNDS, toxicity of 36-0007 HALOGENATED ORGANICS, National Organics Reconnaissance Survey 46-0020 HALOTHANE, explosion during use as anesthetic 51-0010 HALOTHANE, in post-operative hepatitis 44-0017 HALOTHANE, pathological changes in nervous system of rats following in utero exposure 37-0020 HALOTHANE, potential occupational hazard for pregnant operating room personnel 45-0012 HALOTHANE, reproductive and teratologic effects on rats 51-0011 HALOTHANE, teratogenlc effect on rats 32-0035 HAZARD RISKS, guidelines to estimation procedures useful In translating animal test results to human risks 32-0029 HAZARDOUS CHEMICALS, correlation of employee exposure with medical history at Dow Chemical 47-0033 HAZARDOUS CHEMICALS, new manual from Japan covers handling, disposal and toxicity data for over 700 chemicals 47-0040 HAZARDOUS MATERIALS, toxic point determination 46-0051 HAZARDOUS WASTES, disposal of 45-0022 HEAVY METALS, concentration of by bacteria 48-0024 HEAVY METALS, effect on polychaetes 34-0016 HEAVY METALS, tendency to accumulate in rooted plants rather than in biota 48-0024 HEAVY METALS, toxic concentrations in sediments 30-0043 HERBICIDE, new dinitroaniline compound offered by American Cyanamide 43-0037 HERBICIDE, new pre-emergence compound from 3M controls cotton weeds 41-0008 2,2',4,4',5,5'-HEXABROMOBIPHENYL, major component of flame retardant involved in accidental poisoning of cattle and other animals 41-0013 HEXACHLOROBENZENE, absorption, transport, and organotroplsm in the rat 37-0022 HEXACHLOROBENZENE, animal metabolism 37-0021 HEXACHLOROBENZENE, chromatographlc methods for analysis 32-0010 HEXACHLOROBENZENE, clearance and tissue distribution in rats 32-0008 HEXACHLOROBENZENE, detection and confirmation of presence in lipid material at low concentrations 51-0012 HEXACHLOROBENZENE, development of porphyria in rats 48-0016 HEXACHLOROBENZENE, distribution in water, soil, and aquatic organisms 52-0018 HEXACHLOROBENZENE, ecological study of southeastern Louisiana 33-0013 HEXACHLOROBENZENE, effect of removal of sex organs in rat on HCB porphyria 45-0019 HEXACHLOROBENZENE, effect on malathion toxicity in suckling rats 49-0014 HEXACHLOROBENZENE, effect on metabolism of xenobiotics 52-0017 HEXACHLOROBENZENE, effect on plant growth 31-0020 HEXACHLOROBENZENE, effect on rat liver 51-0012 HEXACHLOROBENZENE, effect on the activity of hepatic uroporphyrlnogen carboxylase in the rat 43-0016 HEXACHLOROBENZENE, effects on fetal development in mice and rats 49-0015 HEXACHLOROBENZENE, environmental exposure of man and animals to 35-0015 HEXACHLOROBENZENE, hepatic microsomal enzyme activities 49-0014 HEXACHLOROBENZENE, hepatotoxiclty of 46-0025 HEXACHLOROBENZENE, in blood of children 46-0026 HEXACHLOROBENZENE, metabolites of 47-0018 HEXACHLOROBENZENE, no metabolic products of detected in rabbits 52-0016 HEXACHLOROBENZENE, photolysis of 31-0020 HEXACHLOROBENZENE, porphyrogenlc agent In rats 42-0021 HEXACHLOROBENZENE, potentlatlon of trichloroethylene hepatoxlcity and metabolism 48-0015 HEXACHLOROBENZENE, presence as a contaminant in monkey chow could influence results of toxicological studies with animals 49-0015 HEXACHLOROBENZENE, production, use, and toxicity of 42-0012 HEXACHLOROBENZENE, residues In adipose tissue of German game animals 43-0016 HEXACHLOROBENZENE, teratologic effects in mice 32-0009 HEXACHLOROBENZENE, toxicity and bioaccumulation In rat and guinea pig 52-0019 HEXACHLOROBUTADIENE, analysis for residues in food 48-0016 HEXACHLOROBUTADIENE, distribution in water, soil, and aquatic organisms 51-0013 HEXACHLOROBUTADIENE, ecological study of -17- ------- Ref. No. 52-0020 HEXACHLOROBUTADIENE, In foods grown near perchloroethylene plants 36-0032 HEXAMETHYLPHOSPHORAMIDE (HMPA), inhalation toxicity of 36-0032 HEXAMETHYLPHOSPHORAMIDE (HMPA), potential carcinogen 32-0033 HEXAMETHYLPHOSPHORAMIDE (HMPA), potential carcinogen in rats 30-0046 48-0012 HEXAMETHYLPHOSPHORAMIDE (HMPA), potential inhalation carcinogen in rats 48-0012 HEXAMETHYLPHOSPHORAMIBE (HMPA), solvent used in Kevlar (fiber) production said to cause nose cancers in animals 36-0033 HEXAMETHYLPHOSPHORIC TRIAMIDE (HMPA), potential occupational hazard 47-0031 HEXAVALENT CHROMIUM, possible OSHA exposure standards for 44-0021 HYDRAZINE, acute toxicity experiments 42-0013 HYDRAZINE, effects of acute hydrazine intoxication on rat liver ornithine decarboxylase activity 37-0023 HYDRAZINE, FMC will stop production of unsymmetrical dimethylhydrazine 50-0013 HYDRAZINE, metabolite as carcinogen 49-0010 HYDRAZINE, mutagenic effects of 50-0014 HYDRAZINE, mutation damage 41-0015 HYDRAZINE, Olin expects to be ready in 1978 with a new hydrazine unit that will triple its hydrazine hydrate capacity 41-0014 HYDRAZINE, reactant in the preparation of benzene sulfonyl chloride and other commercial blowing agents 48-0017 HYDRAZINE, teratogenic effects on embryos of the South African clawed toad 52-0021 HYDRAZINE, tumors in mice 50-0015 HYDRAZINE, use in mutation detection systems 41-0015 HYDRAZINE, world demand expected to rise by 15-17%/year 38-0012 HYDRAZINES, fluorescent detection with fluorescamine and Isomeric phthalaldehydes 47-0019 HYDRAZINES, occupational health standards information 38-0007 HYDRAZINE SULFATE, mutagenic potency 27-0007 HYDROCARBON SOLVENTS, potential cause of kidney damage in humans 35-0001 HYDROGEN CYANIDE, possible by-product of Sohio process for manufacture of acrylonitrile 38-0007 N-(2-HYDROXYETHYL) HYDRAZINE, mutagenic potency 29-0004 INDUSTRIAL CHEMICALS, potential environmental hazards 32-0029 INDUSTRIAL HYGIENE, linked with health records of Dow Chemical employees 38-0046 INDUSTRIAL POLLUTANTS, effects on phytoplankton in the North sea 43-0023 INSECTICIDES, effects in the water environment upon plants, animals and humans (a bibliography with abstracts) 43-0024 28-0029 INSECTICIDES, kinetic model for static bioassays 29-0005 INTUMESCENT COATINGS, potential flame-retardants for plastics 30-0021 ISOCYANATES, component of new urethane thermoplastic for quick curing 41-0018 ISOCYANATES, growing demand for polyurethanes suggests strong market for raw materials into the 1980's 34-0006 ISOCYANATES, market gains strength 43-0017 ISOCYANATES, Mobay's new aliphatic isocyanate plant in Baytown, Texas, goes onstream in spring 1976 41-0017 ISOCYANATES, potential health hazard alert sounded for the chemical intermediate, 4,4'- diaminodlphenylmethane 49-0002 ISOCYANATES, potential health hazards when used as a polymer raw material 49-0018 ISOCYANATES, price increase announced by Upjohn 42-0015 ISOCYANATES, price increases announced by three manufacturers 32-0013 ISOCYANATES, significant increase in worldwide consumption predicted over next decade 43-0002 ISOCYANATES, the 50% expansion of Upjohn's LaPorte, Texas facility will cost $20 million 32-0014 ISOCYANATES, Upjohn advertises as useful for a wide variety of urethane products 32-0014 ISOCYANATES, UpJohn's total capacity now at 300 million Ibe/year 50-0026 ISOPROPANOL, cancer cases among employees of processing unit 31-0033 KEPONE, cause of encephalopathy (brain damage) in nine workers at manufacturing plant 27-0037 KEPONE, chlorinated ketone pesticide in blood of hospitalized workers 37-0040 KEPONE, detection in air and water in area of closed manufacturing plant indicates need for long-term health study of residents 38-0048 KEPONE, health effects of and therapy for those affected by this pesticide 39-0038 KEPONE, inducer of liver cancer in mice and rats 39-0036 KEPONE, James River fisherman now suing Life Science Products, Allied Chemical et al for loss of seafood markets 31-0033 KEPONE, manufacturer ordered by EPA to stop production 38-0047 KEPONE, OSHA issues warning to users 47-0032 KEPONE, potential liver carcinogen in rats and mice 29-0020 KEPONE, presence of this pesticide discovered in blood of workers' relatives 37-0041 KEPONE, presence of this pesticide in air and water near closed manufacturing plant prompts request for federal grand jury investigation 39-0037 KEPONE, Senate committee investigates background events leading to this pesticide health and environmental disaster 50-0028 KEPONE, toxicity in workers employed in pesticide manufacture 43-0038 KEPONE, traces up to 5.8 ppb found in mothers' milk in three southern states 41-0003 KEPONE, workers end families file additional suits for damages against former manufacturer 28-0024 KETONES, OSHA Issues proposed health standards 35-0050 LEAD, buildup in humans exposed to auto exhaust emissions 48-0040 LEAD, children of workers In lead smelter get lead poisoning via lead carried home on parents' clothes 43-0020 LEAD, food chain and health implications of airborne -18- ------- Ref. No. 47-0044 LEAD, new process recovers lead from battery scrap without generating sulfur dioxide 40-0033 LEAD, potential cytogenetic effects 48-0039 LEAD, release from glazes and glasses in contact with acid solutions 29-0002 LEAD CHROMATES, potential carcinogens for shipyard workers 48-0039 LEAD POISONING, possible effect of lead leached from glazes and glasses 42-0016 LIQUEFIED COALS, air emissions in burning tests 43-0039 LITHIUM, possible shortage by the year 2000 may constrain certain energy technologies 27-0034 LOW LEVEL CHEMICALS, effect on human health 50-0026 LUBRICANT DEWAXING, cancer cases among employees of processing unit 47-0041 MANGANESE, health effects of and recommended standards for airborne 32-0030 MANGANESE, two cases of employee poisonings reported in California 27-0036 MANGANESE ANTIKNOCK EXHAUST PRODUCTS, toxicity 32-0030 MANGANESE DIOXIDE, potential toxicity of dusts in glazing ceramics 32-0027 MANGANOUS MANGANESE OXIDE, potential toxicity in rats of antiknock residue compound 38-0051 MARINE ZOOPLANKTON, fate of petroleum hydrocarbons in 41-0036 MERCURIAL PESTICIDES, EPA bans use in paint, seed treatment, and golf course turf 41-0036 MERCURIAL PESTICIDES, paint makers may fight EPA on use, claiming phenylmercury compounds in paint do not blomethylate to form toxic compounds 40-0037 MERCURY, increased air emissions from greater use of coal as fuel may be environmental problem based on findings that agricultural plants and soil transform mercury into more toxic methylmercury 43-0021 MERCURY COMPOUNDS, metabolism in microorganisms 32-0034 METHANOL, review of toxicity in light of possible new uses that may present environmental hazards 30-0044 METHANOL, technology and economics of its potential use as fuel 37-0015 METHYL CHLORIDE, concentration and stability in the stratosphere 36-0009 METHYL CHLOROFORM, economic impact assessment of possible regulatory action to control atmospheric emission 27-0036 METHYLCYCLOPENTADIENYL MANGANESE TRICARBONYL, antiknock agent 27-0036 METHYLCYCLOPENTADIENYL MANGANESE TRICARBONYL, manganese exhaust products have low toxicity 32-0027 METHYLCYCLOPENTADIENYL MANGANESE TRICARBONYL, potential toxicity of when ingested by rats 37-0045 METHYLCYCLOPENTADIENYL, proposed antiknock agent may be potential catalyst for converting SO2 to sulfuric acid and particulate sulfates 31-0006 4,4'-METHYLENEBIS(2-CHLORQANILINE) (MOCA), environmental fate 36-0023 4,4'-METHYLENEBIS(2-CHLOROANILINE) (MOCA), hydrolytic stability of 49-0020 4,4'-METHYLENEBIS(2-CHLOROANILINE) (MOCA), new aromatic diamine (called Apocure) advertised as substitute for 41-0020 4,4'-METHYLENEBIS(2-CHLOROANILINE) (MOCA), new urethane elastomers are MOCA-free 27-0013 4,4'-METHYLENEBIS(2-CHLOROANILINE) (MOCA), Polyurethane Manufacturers Association protests OSHA's request for warning signs and protective equipment standards 44-0022 4,4'-METHYLENEBIS(2-CHLOROANILINE) (MOCA), potential health hazard to workers in company producing urethane tracks for snowmobiles 40-0014 METHYLENE CHLORIDE, addition to COj or hydrocarbon propellents may help make them more effective 45-0034 METHYLENE CHLORIDE, effects of exposure from hair sprays 46-0054 METHYLENE CHLORIDE, cardiovascular hazards from use of paint removers containing 31-0021 METHYLHYDRAZINE, distribution in blood and cerebrospinal fluid of monkeys 48-0017 METHYLHYDRAZINE, teratogenic effects on embryos of the South African clawed toad 35-0040 N-METHYL-N'-NITRO-N-NITROSOGUANIDINE, carcinogenic effects on rats as influenced by diet 41-0033 N-METHYL-N'-NITRO-N-NITROSOGUANIDINE, induction of mitotic recombination via treatment in vitro and the host-mediated assay method 35-0038 N-METHYL-N'-NITRO-N-NITROSOGUANIDINE, known mutagen 37-0038 N-METHYL-N'-NITRO-N-NITROSOCUANIDINE, mucosal damage in rat stomach 42-0028 N-METHYL-N'-NITRO-N-NITROSOGUANIDINE, mutagen testing 43-0036 N-METHYL-N'-NITRO-N-NITROSOGUANIDINE, mutagenic effect on cultured mammalian cells 39-0029 N-METHYL-N'-NITRO-N-NITROSOGUANIDINE, mutagenic effects compared with those of Actinomycin D 39-0030 N-METHYL-N'-NITRO-N-NITROSOGUANIDINE, mutagenic effects on cellular slime mold 41-0022 N-Methyl-N'-NITRO-N-NITROSOGUANIDINE, mutagenic effects on Mlcrococcus radiodurans and E. coli B/r 38-0007 N-METHYL-N'-NITRO-N-NITROSOGUANIDINE, mutagenic potency 41-0033 N-METHYL-N'-NITRO-N-NITROSOGUANIDINE, mutagenic studies 43-0035 N-METHYL-N'-NITRO-N-NITROSOGUANIDINE, quantitative mutation assay system 41-0030 N-METHYL-N'-NITRO-N-NITROSOGTJANIDINE, study of mutagen specificity 35-0042 METHYLNITROSOUREA, inducer of mouse lung adenomas 38-0008 N-METHYLOL DIMETHYL PHOSPHONOPROPIONAMIDE, toxicity to goldfish 33-0038 MICROWAVE RADIATION, biological effects and health hazards 32-0032 MICROWAVE RADIATION, potential hazard to human nervous and reproductive systems 29-0026 MINE GASES, hazard to non-coal miners 47-0039 MINING, hazard analysis of metallic and nonmetalllc 47-0039 MINING, safety and health problems of metallic and nonmetalllc 47-0036 MIREX, former Allied Chemical plant in Aberdeen, Mississippi, now being operated by State of Mississippi despite possible EPA ban of Mlrex as potential human carcinogen 39-0018 MIREX, micro-biological fate 36-0017 MODEL AQUATIC ECOSYSTEMS, a modeling strategy 38-0019 MODEL ECOSYSTEM, fate of select pesticides in the aquatic environment 43-0022 MODEL ECOSYSTEMS, biological effects of trace amounts of toxic contaminants in aquatic and terrestrial ecosystems (abstract bulletin) 29-0012 MODEL ECOSYSTEMS, carbon dioxide flux in arctic ecosystems 45-0022 MODEL ECOSYSTEMS, concentration of heavy metals from effluents by bacteria 30-0031 MODEL ECOSYSTEMS, crude oil pollution effects on marine biology 45-0023 MODEL ECOSYSTEMS, degradablllty of organic compounds by microbes 30-0029 MODEL ECOSYSTEMS, distribution and degradation products of heptachlor and organochlorine compounds used in its manufacture and use -19- ------- Ref. No. 36-0019 MODEL ECOSYSTEMS, ecological diversity and species-abundance distributions 39-0012 MODEL ECOSYSTEMS, effects of waste on a stable fish population 30-0030 MODEL ECOSYSTEMS, fate of a triazine herbicide in aquatic system 28-0015 MODEL ECOSYSTEMS, feedback dynamics analysis of secondary successional transients in ecosystems 48-0023 MODEL ECOSYSTEMS, heavy metals in estuarine ecosystem 52-0027 MODEL ECOSYSTEMS, interdisciplinary concepts and formulations for water systems 52-0026 MODEL ECOSYSTEMS, large scale systems approach to estuarine water quality modelling with multiple constituents 37-0024 MODEL ECOSYSTEMS, mathematical models in ecochemistry 52-0026 MODEL ECOSYSTEMS, matrix model for simulating concentration distribution of water quality constituents with coupled reactions in an estuary 36-0018 MODEL ECOSYSTEMS, movement of pesticides through the environment 41-0021 MODEL ECOSYSTEMS, role of plant residues in retention of cadmium in ecosystems 30-0028 MODEL ECOSYSTEMS, use in studying kinetic behavior of chemicals in the environment 42-0004 MONO-ACETYL BENZIDINE, colorimetric assay for determination in urine and water 35-0010 MONOAMMONIUM PHOSPHATE, Monsanto1s (Phos-Chek) flame retardant, used to combat forest fires near Los Angeles 37-0012 MONOFLUOROTRICHLOROMETHANE, atmospheric concentrations 37-0011 MONOFLUOROTRICHLOROMETHANE, distribution and fate in animals inhaling 36-0008 MONOFLUOROTRICHLOROMETHANE, effects on tracheobronchial particle deposition and clearance in donkeys 37-0010 MONOFLUOROTRICHLOROMETHANE, metabolic effects in various animals 44-0021 MONOMETHYLHYDRAZINE, acute and chronic toxicity experiments 49-0017 MONOMETHYLHYDRAZINE, effect of electrode Implantation on seizure response to 29-0011 MONOMETHYLHYDRAZINE,"effect on red blood cell metabolism 49-0016 MONOMETHYLHYDRAZINE, effects on guinea pigs 49-0016 MONOMETHYLHYDRAZINE, immunologlcal response in guinea pigs following exposure to 49-0017 MONOMETHYLHYDRAZINE, induction of seizures by 29-0010 MONOMETHYLHYDRAZINE, neurophysiological and behavioral effects on cats 35-0042 MONONITROSOPIPERAZINE, inducer of mouse lung adenomas 35-0038 MUTAGEN, NIH scientists have synthesized a potent mutagen identified as a diol epoxide of benzo[a]pyrene 31-0006 38-0007 36-0001 42-0004 42-0005 52-0011 35-0005 34-0007 36-0010 38-0007 29-0003 34-0007 47-0007 1-NAPHTHYLAMINE, a-NAPHTHYLAMINE , 2-NAPHTHYLAMINE, 2-NAPHTHYLAMINE, 2-NAPHTHYLAMINE , 2-NAPHTHYLAMINE, 8-NAPHTHYLAMINE, B-NAPHTHYLAMINE, B-NAPHTHYLAMINE, B-NAPHTHYLAMINE, B-NAPHTHYLAMINE, NAPHTHYLAMINES, 1 environmental fate mutagenlc potency carcinogenic to man colorimetric assay for detection in urine and water presence in Kentucky school laboratories of potential carcinogens indicates need for schools to enforce safety standards for exposure substitute or process changes in manufacturing human and animal carcinogen industry's failure to screen potential carcinogenicity monitoring with a portable mass spectrometer mutagenlc potency potential bladder carcinogen NAPHTHYLAMINES , bladder-cancer deaths of British rubber workers on Increase despite discontinued use of 45-0032 NAPHTHYLAMINES, effect of exposure to 33-0036 NICKEL, possible bioaccumulation in man and animals 32-0028 NICKEL SULFIDE, potential inhalation toxicity in rats 32-0028 NICKEL SULFIDE, potential pulmonary carcinogen in rats 39-0010 NITRIC OXIDE, balloon probes will study its effects on stratospheric ozone 27-0015 NITRILOTRIACETIC ACID, carcinogenicity potential apparently confirmed in recent animal studies 32-0016 NITRILOTRIACETIC ACID, degradability when used as detergent substitute 32-0016 NITRILOTRIACETIC ACID, effects on wastewater when used as substitute laundry detergent 38-0021 NITRILOTBIACETIC ACID, identification of urinary excretion product 30-0032 NITRILOTRIACETIC ACID, potential carcinogen affects urinary tract in rats and mice 27-0014 NITRILOTRIACETIC ACID, potential carcinogenicity and toxicity In mice 27-0015 NITRILOTRIACETIC ACID, potential renal carcinogen in rats and mice 32-0016 NITRILOTRIACETIC ACID-METAL COMPLEXES, degradability in activated sludge system when NTA used as detergent substitute 48-0034 NITRITES, health problems associated with 45-0030 NITROFURANS, FDA action in banning as carcinogenic 40-0036 2-NITRO-P-PHENYLENEDIAMINE, hair dye shown to be cytotoxic to cultured Chinese hamster cells 40-0036 4-NITRO-O-PHENYLENEDIAMINE, hair dye shown to be cytotoxic to cultured Chinese hamster cells 42-0030 NITROPHENYLENEDIAMINES, hair dyes reported to be non-mutagenic and non-teratogenic 50-0030 NITROPHENYLENEDIAMINES, potent mutagens in bacteria and carcinogen's in mice 41-0028 NITROSAMINES , a-acetoxy compounds are extremely hazardous "contact carcinogens" 41-0028 NITROSAMINES, a-acetoxy compounds are mutagenic per ae 47-0029 NITROSAMINES, biological activity of principal products from reaction In the Udenfriend system 47-0028 NITROSAMINES, carcinogenic effects on Chinese hamsters 35-0043 NITROSAMINES, carcinogenicity and public health aspects 40-0031 NITROSAMINES, environmental and consumer groups urge USDA to push for even lower limits of nitrites and nitrates in foods than those proposed to insure public health safety from nitroaamines 48-0036 NITROSAMINES, formation from industrial metal grinding fluids 48-0034 NITROSAMINES, health products associated with 51-0025 NITROSAMINES, in fumes from frying bacon 35-0042 NITROSAMINES , inducers of mouse lung adenomas 43-0034 NITROSAMINES, inhibition of formation In fried bacon by propyl gallate and ascorbyl palmitate 38-0039 NITROSAMINES, known animal carcinogens now detected in air, water, soil, and sewage treatment plants may pose health hazard 47-0029 NITROSAMINES, mutagenlc studies -20- ------- Ref. No. 33-0033 NITROSAMINES, no indication of presence of volatile N-nitrosamines at the part per trillion level in New Orleans and Boston water supplies 47-0019 NITROSAMINES, occupational health standards information 48-0038 NITROSAMINES, photoelectron spectra 49-0035 NITROSAMINES, photolytic degradation 33-0034 NITROSAMINES, possible ban on nitrate additives for foods 48-0035 NITROSAMINES, possible source of carcinogens 30-0045 NITROSAMINES, potential air and water pollutants 51-0026 NITROSAMINES, potential hazards from pesticide residues left on food 44-0036 NITROSAMINES, reaction product from N-nitrosation of atrazine is stable In water but is decomposed by light 44-0036 NITROSAMINES, reaction product from N-nitrosation of atrazine might form in soil and be leached into ground waters 44-0037 NITROSAMINES, reactions with organo-metallic reagents 51-0027 NITROSAMINES, review of the literature 50-0012 NITROSAMINES, solubility characteristics and carcinogenicity 49-0033 NITROSAMINES, studies on carcinogenic effects of nitrites and amines in rats 33-0032 NITROSAMINES, toxic constituents of animals foodstuffs 35-0036 N-NITROSAMINES, potential carcinogens, mutagens, or teratogens 52-0039 N-NITROSAMINES, survey of food products 35-0043 NITROSO COMPOUNDS, carcinogenicity and public health aspects 27-0032 N-NITROSO COMPOUNDS, carcinogenicity 49-0036 N-NITROSO COMPOUNDS, detection in ambient air 44-0035 N-NITROSO COMPOUNDS, presence in the environment 27-0032 N-NITROSOCARBARYL, carcinogenicity in rats 41-0034 N-NITROSOCHLORDIAZEPOXID, mutagenic effects of this N-nitrosamine derivative of the tranqullizer chlordiazepoxld 48-0036 N-NITROSODIETHANOLAMINE, formation from a grinding fluid under simulated gastric conditions 52-0037 N-NITROSODIMETHYLAMINE, in air 49-0035 N-NITROSODIMETHYLAMINE, photolytic degradation 46-0045 N-NITROSODIMETHYLAMINE, short half-life in direct sunlight Indicates that this carcinogen formed from emissions of dlmethylamlne during night operations will quickly disappear from air 35-0036 N-NITROSO-4-HYDROXYPROLINE, pulse polarographic analysis 40-0028 N-NITROSOMETHYLUKEA, effect on organ cultures of human embryonic lung and kidney tissues 42-0028 N-NITROSO-N-METHYLUREA (ETHYL METHANESULFONATE) , mutagen testing 35-0043 NITROSO-METHYLURETHANE, potential carcinogen 42-0029 N-NITROSOMDRPHOLINE, inducer of liver and lung tumors 35-0042 N-NITRQSOMORPHOLINE, inducer of mouse lung adenomas 47-0029 NITROSOPIPERIDINE, biological activity of principal product from reaction in the Udenfrlend sys tern 47-0029 NITROSOPIPERIDINE, mutagenic studies 35-0043 NITROSOPIPERIDINE, presence in extract from dried tobacco leaves 35-0036 N-NITROSOPROLINE, pulse polarographic analysis 41-0028 NITROSOPYRROLIDINE, cause of liver and testlcular tumors in rats 52-0038 N-NITROSOPYRROLIDINE, in cooked pork 43-0034 NITROSOPYRROLIDINE, inhibition of Its formation in fried bacon by propyl gallate and ascorbyl palmitate 35-0036 N-NITROSOPYRROLIDINE, pulse polarographic analysis 49-0031 NITROSOSARCOSINE, effect on dimethyInitrosamine metabolism and toxlcity 30-0019 NITROUS OXIDE, potential danger to stratosphere via formation from nitrogen-based fertilizers 40-0009 NITROUS OXIDE, stratospheric concentrations 47-0035 OCCUPATIONAL HAZARDS, pending legislation requiring involvement of Secretary of Labor in alerting employees 47-0046 OCCUPATIONAL HEALTH, wide use of trade names for chemical products hinders control of occupational hazards 47-0042 OCEAN DUMPING, panel of National Academy of Engineering criticizes EPA's current regulations governing municipal waste disposal 38-0050 OCEAN DUMPING, report to Congress on Federally sponsored research on effects of ocean disposal 30-0006 OCTABROMOBIPHENYL, ultrastructural changes in rat liver 52-0029 OIL SHALE, analysis of geological forces and stresses acting on deep shales 52-0030 OIL SHALE, ERDA producing 100 bbl of oil at Rock Springs, Wyoming In situ test well extracted from shale 52-0029 OIL SHALE, geologic and environmental Information on deposits in Western Colorado will be gathered for Bureau of Mines 38-0026 OIL SHALE, Utah permits Oil Shale Corp. (Tosco) to unitlze 29 separate state oil shale leases that may lead to 75,000 bbl/day plant 28-0014 OIL SHALE LIQUEFACTION, pros and cons of processes under development 47-0022 OPTICAL BRIGHTENERS, new liquid Oreo Synthrowite PDA from Organic Chem. Corp. in Rhode Island is designed primarily for polyester fibers 33-0019 OPTICAL BRIGHTENERS, structure and Industrual applications 46-0001 ORGANO-ISOCYANATES, among 23 chemicals for which NIOSH may develop recommended standards for occupational exposure to by 1980 38-0008 ORGANOPHOSPHORUS FLAME RETARDANTS, toxlcity to goldfish 40-0028 ORTHOAMINOAZOTOLUENE, effect on organ cultures of human embryonic lung and kidney tissues 28-0024 OSHA, health standards expected to have smoother road now 27-0031 OXIDATION HAIR DYES, apparently non-toxic and non-carcinogenic in mice skin tests 27-0039 OXONIUM SALTS, new thermally-stable solids synthesized from antimony pentafluoride and hydrogen fluoride 38-0009 OZONE, depletion over the North Pole following a 1972 solar proton event seen as confirmation of ozone depletion theory 38-0011 OZONE, measurement techniques to help understand behavior of propellents in the atmosphere -21- ------- Ref. No. 38-0010 47-0012 45-0018 28-0011 OZONE, possible existence of a tropospheric sink may change predicted effects of chlorofluorocarbons in stratosphere OZONE DEPLETION, NAS report on effects of fluorocarbona delayed OZONE DEPLETION, overestimation of effect of fluorocarbons on OZONE THEORY, natural sources of stratospheric chlorine and reformation of ozone by action of sunshine on oxygen are among reasons for questioning 33-0035 PAINTS, erosion effects of gaseous pollutants 29-0002 PAINTS, potential carcinogens for shipyard workers 36-0022 PALATINOL DIOCTYL PHTHALATE, BASF Wyandotte increases price of 47-0020 PARATHION, degradation in seawater 47-0020 PARATHION, environmental stability of degradation products of 33-0037 PATHOGENIC BACTERIA, possible presence in gaseous effluents from sewage treatment plants 43-0016 PENTACHLOROBENZENE, effects on fetal development in mice and rats 29-0022 PENTACHLOROPHENOL, detected in human urine and seminal fluid 29-0022 PENTACHLOROPHENOL, potential genetic and carcinogenic hazard 31-0010 PENTAMETHYLPHOSPHOROTRIAMIDE, new flame retardant for cottons 37-0043 PERACETIC ACID, potential tumor promoter and skin carcinogen 37-0014 PERCHLOROETHYLENE, analysis in atmosphere by gas chromatography-mass spectrometry 33-0021 PERCHLOROETHYLENE, analysis in drinking water 33-0020 PERCHLOROETHYLENE, chemical and biological reactivity in rats in relation to acute liver toxic!ty 37-0016 PERCHLOROETHYLENE, concentrations in atmosphere 35-0018 PERCHLOROETHYLENE, description of PPG Industries' oxychlorination/oxyhydrochlorination process . for manufacture of 45-0025 PERCHLOROETHYLENE, effect on embryonal and fetal development in rats and mice 31-0024 PERCHLOROETHYLENE, Ethyl will continue to produce and market even after discontinuing 1,1,1-trichloroethane production 45-0024 PERCHLOROETHYLENE, hazards from welding in air contaminated with 41-0001 PERCHLOROETHYLENE, imports in 1975 reached about 37.5 million Ib or 58.7% more than in 1974 27-0010 PERCHLOROETHYLENE, increase in production may be way for carbon tetrachloride producers to combat cut in demands if fluorocarbon ban goes into effect 35-0019 PERCHLOROETHYLENE, mutagenicity 46-0031 PERCHLOROETHYLENE, OSHA may reconsider standards for 29-0013 PERCHLOROETHYLENE, persistence in natural water bodies 44-0024 PERCHLOROETHYLENE, photodecomposition rates under simulated atmospheric conditions 38-0037 PERCHLOROETHYLENE, photooxidation reactivity and products 48-0026 PERCHLOROETHYLENE, possible source of atmospheric carbon tetrachloride 27-0020 PERCHLOROETHYLENE, presence in drinking water 35-0034 PERCHLOROETHYLENE, price to go up lc/lb 37-0001 PERCHLOROETHYLENE, production rise anticipated in 1976 43-0037 PERFLUIDONE, new cotton weed herbicide from 3M 28-0026 PESTICIDE, Kepone manufacturer fined by OSHA for violations of safety measures 28-0026 PESTICIDE, wastes from factory show excessive concentrations of Kepone, a chlorinated ketone pesticide 48-0025 PESTICIDES, bioconcentration by algae 35-0005 PESTICIDES, EPA's "nine principles" of carcinogenicity receive support from NAS 43-0014 PESTICIDES, mortality survey 37-0044 PESTICIDES, organochlorine residues in eggs of peregrine falcons cuts their reproductive rate 33-0039 PESTICIDES, teratogenicity of organophosphorus and methyl carbamate types 37-0024 PESTICIDES, transport mechanisms and biological effects 31-0002 PESTICIDES, transport through soil 38-0049 PETROLEUM HYDROCARBON TOXICITY, animal and human responses to vapors 38-0051 PETROLEUM HYDROCARBONS, fate in marine zooplankton 51-0014 PHENYLHYDRAZINE, induction and study of accessory spleens in rabbits 41-0016 PHENYLHYDRAZINE, mechanism of oxidation 41-0016 PHENYLHYDRAZINES, intermediates and products of its oxidation may be responsible for its biological effects 29-0003 PHENYL PHENOL, potential bladder carcinogen 45-0024 PHOSGENE, formation by welding in air contaminated with perchloroethylene 32-0031 PHOSGENE, potential toxic chemical in rubber industry 31-0010 PHOSPHORAMIDE DERIVATIVES, flame retardants for cottons 46-0050 PHOSPHORUS, toxicity to codfish 35-0020 PHTHALATE ESTER, minute amounts detected in water samples from Gulf of Mexico 38-0022 PHTHALATE ESTERS, detection of trace quantities in environmental samples 46-0032 PHTHALATES, acute and chronic toxicities of 33-0022 PHTHALATES, detection in air 33-0023 PHTHALATES, detection in open-ocean biota samples 36-0021 PHTHALATES, FMC increases price of 37-0026 PHTHALATES, occurrence in water and organisms 29-0004 PHTHALATES, sudden peak in production typifies difficulty in predicting production increases or new uses for estimating environmental impact of chemicals 38-0046 PHYTOPLANKTON, effects of industrial pollution in the North Sea 38-0024 PLASTICS, market review 44-0041 PLASTICS, photodegradable trash bags now on market 27-0038 PLUTONIUM-239, cytogenetic effects in mice 28-0027 PLUTONIUM-239, maximum permissible body burden 33-0040 PLUTONIUM OXIDE, air shipments banned 37-0024 POLLUTANTS, human mutagenlc, carcinogenic, and teratogenic effects 39-0035 POLLUTANTS, transport of ozone over 200-mile distance 27-0035 POLYBENZIMIDAZOLES, properties and potential applications 30-0007 POLYBROMINATED BIPHENYLS, detection of residues In dairy products 30-0008 POLYBROMINATED BIPHENYLS, effects on liver of Japanese quail 44-0011 POLYBROMINATED BIPHENYLS, retention and excretion by hens -22- ------- Ref. No. 30-0008 POLYBROMINATED BIPHENYLS, tissue distribution in Japanese quail 41-0010 POLYBROMOBIPHENYLS, environmental chemistry of flame retardants 44-0025 POLYCHLORINATED BIPHENYLS, adsorption from aqueous solutions and raw sewage by various adsorbents 41-0037 POLYCHLORINATED BIPHENYLS, Canadian researchers find new bacteria strain that breaks down PCB's in waste water 39-0031 POLYCHLORINATED BIPHENYLS, continued contamination of fish and wildlife spurs Monsanto to drop production of PCB's 35-0049 POLYCHLORINATED BIPHENYLS, Dow Chemical and McGraw Edison announce development of a butylated monochlorodlphenyl oxide as safe PCS substitute 29-0021 POLYCHLORINATED BIPHENYLS, excessively high levels in Lake Michigan fish adds to current hazard concern 28-0025 POLYCHLORINATED BIPHENYLS, HEW and other groups urge EPA to void GE's discharge permit 28-0025 POLYCHLORINATED BIPHENYLS, potential genetic hazard in monkeys 28-0025 POLYCHLORINATED BIPHENYLS, potential liver carcinogen in rats 29-0024 POLYCHLORINATED BIPHENYLS, presence In Virginia watershed indicative of their spread and persistence in water 40-0038 POLYCHLORINATED BIPHENYLS, toxic and genetic effects argue for discontinuing their use and possible alternatives are being suggested 40-0034 POLYELECTROLYTES, acute toxicity to marine animals 39-0008 POLYETHYLENEIMINE POLYMERS, properties, reactions, uses and toxicity 49-0007 POLYMERIC BINDERS, precaution advised for their use in polyurethane paints and vinyl chloride paints 36-0024 POLYURETHANE, advances in technology 39-0020 POLYURETHANE, degradation mechanisms 40-0016 POLYURETHANE, employees exposed to potentially toxic toluene 2,4-dlisocyanate 38-0023 POLYURETHANE, expansion of Firestone Tire & Rubber's Milan, Texas, foam rubber plant will raise capacity 25% by mid-1977 39-0020 POLYURETHANE, mechanism of HCN evolution 44-0023 POLYURETHANE, potential health hazard in PVC extruded hose manufacture 40-0018 POLYURETHANE, prepolymerized single-component formulation available In an aerosol can 34-0006 POLYURETHANE CHEMICALS, market gains strength 36-0023 POLYURETHANE ELASTOMERS, hydrolytic stability of 43-0002 POLYURETHANE FOAM, Firestone expects to complete 25% expansion of Its Milan, Tenn. plant by mid-1977 27-0021 POLYURETHANE FOAM, Increasing packaging market anticipated 27-0021 POLYURETHANE FOAM, reduced toxicity due to switch from TDI (toluene-based) chemistry to MDI (methylene-based) chemistry 44-0025 POLYURETHANE FOAMS, effective adsorbents for PCB's from aqueous solutions 42-0019 POLYURETHANE LATICES, possible means of meeting air pollution regulations for solvent based fabric coatings 49-0007 POLYURETHANE PAINTS, potential health hazards 44-0027 POLYURETHANES, basis of new thermoplastlc-thermosettlng polymers for use as adhesives and polymer reinforcing materials 35-0021 POLYURETHANES, combination of polyurethane and steel reinforcing wire gives abrasion-resistant screens for classifying ores, stone, chemicals, and other materials 41-0018 POLYURETHANES, consumption drop in 1975 was slight compared to other plastics and solid growth is expected into 1980'a 38-0024 POLYURETHANES, consumption dropped about 20X in 1975 31-0027 POLYURETHANES, degradation 51-0017 POLYURETHANES, Increased production 34-0008 POLYURETHANES, market growth predicted 43-0026 POLYURETHANES, new one-component system Hypol FHP foam from W.R. Grace seen as competive packaging material 51-0018 POLYURETHANES, producers fund graduate school course 29-0014 POLYURETHANES, strong market demand foreseen for all foam types to 1980 49-0022 POLYURETHANES, urethane foam enjoying market comeback 49-0028 POLYVINYL CHLORIDE, advent of dark colors and coextruslon foreshadow a growing market for house siding 40-0026 POLYVINYL CHLORIDE, B.F. Goodrich research program yields PVC virtually free of entrapped VCM 38-0003 POLYVINYL CHLORIDE, bibliography of industrial health hazards due to atmospheric factors 38-0024 POLYVINYL CHLORIDE, consumption dropped about 20* in 1975 48-0032 POLYVINYL CHLORIDE, decision expected soon from Texas Air Control Board re: expansion of Tenneco Chemicals' PVC plant in Pasadena, Texas 27-0025 POLYVINYL CHLORIDE, drop in demand predicted for 1975 should turn around in 1976 but still fall short of 1974 level 44-0025 POLYVINYL CHLORIDE, effective adsorbent for PCB'a from raw sewage 36-0027 POLYVINYL CHLORIDE, EPA assessment of environmental problems 32-0025 POLYVINYL CHLORIDE, explosive potential of powders 41-0001 POLYVINYL CHLORIDE, exports in 1975 were 175.7 million Ib or 44.6* less than in 1974 27-0026 POLYVINYL CHLORIDE, FDA to ban some uses of PVC In food packaging 41-0025 POLYVINYL CHLORIDE, Goodyear'8 plans to expand dispersion resins capacity at Niagara Falls will restore over 50% of capacity lost after shut down last year 31-0029 POLYVINYL CHLORIDE, Government safety and pollution standards force Unlroyal Chemical to stop production 42-0023 POLYVINYL CHLORIDE, haemolytic activity of certain PVC particles traced to Ionic detergent used In preparation of PVC paste or emulsion polymers 46-0039 POLYVINYL CHLORIDE, Incidence of disease In workers exposed to 39-0024 POLYVINYL CHLORIDE, industry is prepared to accept EPA standards for regulating air emissions from PVC plants 35-0029 POLYVINYL CHLORIDE, manufacturers are working to reduce VC emissions before 1 April deadline of OSHA standards 35-0030 POLYVINYL CHLORIDE, new 50-million-lb/yr Perryvilla, Md. plant makes Firestone Plastics Co. largest U.S. producer of PVC dispersion resins 38-0031 POLYVINYL CHLORIDE, new permanent plasticlzer resins under development by Du Font -23- ------- Ref. No. 37-0031 POLYV1NYL CHLORIDE, not seen as health hazard in mortality study of Welsh workers 29-0017 POLYVINYL CHLORIDE, possible ban by FDA of use in food packages will not seriously affect market 38-0035 POLYVINYL CHLORIDE, possible effects of changing Economics of ethylene production 40-0022 POLYVINYL CHLORIDE, potential carcinogenic hazard in blending room areas of PVC pipe manufacturing plant 48-0033 POLYVINYL CHLORIDE, price increase for resins and compounds announced by Diamond Shamrock 35-0034 POLYVINYL CHLORIDE, price increased to 24C and 25e/lb 37-0001 POLYVINYL CHLORIDE, production rise anticipated in 1976 45-0028 POLYVINYL CHLORIDE, respiratory illness from exposure to pyrolysis products of 45-0027 POLYVINYL CHLORIDE, respiratory tract problems in workers exposed to pyrolysis products of 46-0043 POLYVINYL CHLORIDE, sales through 1980 31-0028 POLYVINYL CHLORIDE, substitute materials may claim 40% of PVC packaging materials market 41-0026 POLYVINYL CHLORIDE, Tenneco Chemicals, Inc. announces that it now can remove over 98% of previously contained residual VC from its resins 36-0030 POLYVINYL CHLORIDE, Tenneco Chemicals, Inc. to expand its Pasadena, Texas plant 43-0033 POLYVINYL CHLORIDE, thermal degradation behavior with polystyrene 46-0037 POLYVINYL CHLORIDE, toxicity in fires 46-0033 POLYVINYL CHLORIDE, toxicology of PVC devices used in contact with blood 39-0019 POLYVINYL CHLORIDE, toxicology of plastic devices in contact with blood 28-0020 POLYVINYL CHLORIDE DUST, biological reactivity 28-0021 POLYVINYL CHLORIDE RESINS, new stripping process reduces vinyl chloride content 38-0030 POLYVINYL CHLORIDE SHINGLES, use as roof sheathing for solar-heated home hot water supply 31-0006 PROPIOLACTONE, environmental fate 41-0022 B-PROPIOLACTONE, mutagenic effects on Micrococcus radiodurans and E. coli B/r 38-0007 B-PROPIOLACTONE, mutagenic potency 46-0004 PROPYLENE, production in 1976 may rise to almost 10 billion Ib but price is expected to remain firm at about 8.5c/lb 34-0014 PROPYLENE OXIDE, potential mutagen 38-0008 PROVATEX CP, toxicity to goldfish 39-0041 RED DYE NO. 2, FDA finally bans its use in foods, drugs, and cosmetics 38-0044 RED DYE NO. 2, FDA studies indicating cancer in female rats fed heavy dosages 42-0032 RED DYE NO. 40, potential lymph gland carcinogen 44-0040 RUBBER CHEMICALS, potential cause of leukemia 44-0039 RUBBER SOLVENTS, potential cause of leukemia 33-0037 SEWAGE TREATMENT PLANTS, potential health hazards of air pollutants from 27-0022 SHALE, potential source of soda ash and sodium bicarbonate 46-0028 SHALE CONVERSION, higher natural gas prices plus better availability of coal and increasing use of oil and gas for petrochemicals spur research and development 46-0036 SHALE OIL, analysis of environmental problems associated with development of 33-0025 SHALE OIL, arsenic removal process 46-0035 SHALE OIL, development faces funding problems and objections of environmentalists 28-0014 SHALE OIL, disposal of spent shale is problem of liquefaction 41-0019 SHALE OIL, ERDA reports oil shale is still part of its synthetic fuels commercialization program 50-0022 SHALE OIL, funds for technology research on in situ recovery 28-0018 SHALE OIL, metallic contaminants and other Impurities necessitate pretreatment of raw shale oil before refining 52-0030 SHALE OIL, more advanced fracturing process for shale and new methods of igniting oil shale used to produce 100 bbl of oil 35-0025 SHALE OIL, proposed 4,000 ton/day plant to be built by American Lurgi Corp. and Dravo Corp. will have low NO and S02 emissions 46-0035 SHALE OIL, Shell's development plan 27-0022 SHALE OIL, solution method of extraction could prevent some ecological problems 39-0023 SHALE OIL, Soviet processes offered for U.S. licensing 38-0016 SHALE OIL EXTRACTION, technology and environmental effects 43-0029 SHALE OIL INDUSTRY, financial and technical status of U.S. ventures 48-0019 SHALE OIL RECOVERY, potential wastewater pollutants 39-0022 SHALE TARS, toxicological effects on guinea pigs 46-0048 SILICOSIS, state-of-the art review on 49-0039 SODA ASH, closing of Diamond Shamrock's synthetic soda and plant in Ohio reduces current U.S. capacity to 1.97 million tons/yr 27-0029 SODIUM BICHROMATE, suspect lung carcinogen in Japanese industry 34-0011 SODIUM LIGHTS, effect on tree and leaf growth 38-0045 SOLAR ENERGY COLLECTORS, heating and cooling for buildings 39-0032 SOLAR POWER STATIONS, proposed new source of electrical energy 29-0002 SOLVENTS, potential carcinogens for shipyard workers 38-0049 SOLVENTS, suggested hygienic standards for 60 solvent, 70 solvent and 104° Flash Aliphatic solvent 38-0049 SOLVENTS, toxicity studies of 60 solvent, 70 solvent and 104° flash aliphatic solvent 46-0053 SPRAY ADHESIVES, consequences of premature allegations of teratogenicity and mutagenicity 29-0027 STEEL WORKERS, mortality patterns of Pennsylvania workers 40-0035 STYRENE, potential carcinogenic hazards of inhaled vapor 45-0035 STYRENE, potential link to leukemia 44-0040 STYRENE-BUTADIENE, synthetic rubber production as potential cause of leukemia 40-0035 STYRENE OXIDE, metabolic derivative of styrene is shown to be mutagenic for Salmonella tYphimurium 27-0019 SUBSTITUTED-STILBENE FLUORESCENT WHITENING AGENTS, phototoxicity and photocarcinogenicity on mouse skin 27-0016 SULFOSATED STILBENE FLUORESCENT WHITENING AGENTS, accumulation in fish 41-0014 SULFONYL HYDRAZIDES, chemistry and decomposition products of some commercial blowing agents -24- ------- Ref. No. 50-0027 SYM-TETRACHLOROETHANE, most toxic of all common chlorinated hydrocarbons 41-0035 SYNTHETIC FUELS, biomass conversion reported to be technically feasible, almost economically competitive and environmentally attractive 41-0019 SYNTHETIC FUELS, ERDA anticipates passage soon by Congress of loan guarantee bill that will permit ERDA to launch commercialization program 35-0044 SYNTHETIC SMOG, carcinogenic and cocarcinogenic effects of inhalation on Syrian hamsters 28-0016 TEREPHTHALIC ACID, its absorption, distribution and excretion in rabbits and rats 28-0016 TEREPHTHALIC ACID, potential health hazards 28-0022 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN (TCDD), potential health hazard 28-0022 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN (TCDD), wastes contaminant causes epidemic 49-0037 l,2,3,4-TETRACHLORO-5,5-DIMETHOXYCYCLOPENTADIENE, recent tests with rats and rabbits show this chemical to be very toxic by several routes of administration 43-0025 TETRACHLOROETHYLENE, breath decay curves for monitoring time-weighted average exposures 35-0019 TETRACHLOROETHYLENE, mutagenicity 36-0006 TETRAKIS (HYDROXYMETHYL) PHOSPHONIUM CHLORIDE (THPC)-DERIVED FINISH, flame retardant developed Jointly by UM&M and Cotton Inc. 38-0008 TETRAKIS (HYDROXYMETHYL) PHOSPHONIUM HYDROXIDE, toxicity to goldfish 42-0014 TETRAMETHYLHYDRAZINE HYDROCHLORIDE, tumor inducer in mice 34-0016 THALLIUM, tendency to settle into stream sediment and not move up through food chain 38-0045 THERMAL ENERGY, use in buildings from solar collections 49-0040 THERMAL POLLUTION CONTROL, potential hazard to aquatic life from chloramines 38-0008 THPOH, toxicity to goldfish 44-0039 TIRE-CURING FUMES, possible cause of lung cancer 47-0045 TITANIUM DIOXIDE, beneficiated-ilmenite process recycles HC1 leach liquor 41-0001 TITANIUM DIOXIDE, imports in 1975 of about 53 million Ib were 24.3Z less than In 1974 39-0034 TNT, adequacy of the 1.5 mg/m3 threshold limit value is questioned on basis of biological effects of exposure at lower level 42-0033 TOLUENE, long-term inhalation studies on rats to be conducted 43-0002 TOLUENE DIISOCYANATE, Dow Chemical's new Freeport, Texas plant nears completion 41-0018 TOLUENE DIISOCYANATE, Dow will enter field in 1976 and current producers are expanding capacities 30-0022 TOLUENE DIISOCYANATE, emissions from polyurethane resin manufacturing 33-0014 TOLUENE DIISOCYANATE, industry plans price Increases 49-0022 TOLUENE DIISOCYANATE, possible price increase may follow rising urethane foam market 49-0007 TOLUENE DIISOCYANATE, potential health hazard in polyurethane paints 44-0023 TOLUENE DIISOCYANATE, potential health hazard in PVC extruded hose manufacture 48-0018 TOLUENE DIISOCYANATE, price hike by five manufactures 27-0011 TOLUENE DIISOCYANATE, price increase 42-0015 TOLUENE DIISOCYANATE, price increase announced by Olin 32-0012 TOLUENE DIISOCYANATE, representative of dllsocyanates used in new Dow rigid urethane engineering plastic, Instant Set Polymer 27-0021 TOLUENE DIISOCYANATE, trend towards MDI (methylene-based) chemistry Instead of TDI reduces toxicity potential in polyurethane field 44-0022 TOLUENE 2,4-DIISOCYANATE, potential health hazard to workers in company producing urethane tracks for snowmobiles 40-0016 TOLUENE 2,4-DIISOCYANATE, potential toxic to workers in polyurethane foam molding department 31-0036 TOXAPHENE, air transport 47-0034 TOXIC CHEMICALS, environmentalists and chemical Industry reaching agreement on regulatory legislation for 46-0051 TOXIC WASTES, disposal of 45-0039 TOXIC WASTES, potential hazards from disposal of 42-0001 TOXICITY TESTING, advances in testing the toxicity of substances to fish 51-0029 TOXICOLOGY, U.S. chemical companies extend facilities and laboratories to test potential effects of their products 43-0022 TRACE CONTAMINANTS ABSTRACTS, published by Oak Ridge National Laboratory 47-0037 TRACE ELEMENTS, effects on man and the environment 35-0048 TRACE METALS, Imbalance among mercury, selenuim and bromine may be cause of premature pupping In sea lions 43-0040 TRACE METALS, potential health hazards in air 46-0052 TRACE METALS, potential Influence on heart disease and cancer 28-0028 TRACE ORGANIC CONTAMINANTS IN DRINKING WATER, concentration of by reverse osmosis 33-0036 TRANSITION METALS, bioaccumulatlon 33-0036 TRANSITION METALS, biochemical activities 36-0007 TRIBROMOMETHANE (BROMOFORM), National Organlcs Reconnaissance Survey for halogenated organics 38-0052 1,1,1-TRICHLOROETHANE, hepatic lesions in mice after continuous exposure to 41-0038 1,1,1-TRICHLOROETHANE, inhalation cited as cause of brain and central nervous system damage in law suit 37-0014 TRICHLOROETHYLENE, analysis in atmosphere by gas chromatography-mass spectrometry 51-0019 TRICHLOROETHYLENE, ban by FDA for use in coffee 33-0020 TRICHLOROETHYLENE, chemical and biological reactivity in rats in relation to acute liver toxicity 42-0021 TRICHLOROETHYLENE, chemically Induced potentlation of its hepatotoxicity and metabolism 52-0028 TRICHLOROETHYLENE, covalent interaction of metabolites in rat hepatic mlcrosomes 35-0018 TRICHLOROETHYLENE, description of PPG Industries' oxychlorlnatlon/oxyhydrochlorlnation process for manufacture of 45-0025 TRICHLOROETHYLENE, effect on embryonal and fetal development in rats and mice 31-0024 TRICHLOROETHYLENE, Ethyl will continue to produce and market even after discontinuing production of 1,1,1-trichloroethane 43-0028 TRICHLOROETHYLENE, final results of NCI testing show development of liver cancers in mice 45-0024 TRICHLOROETHYLENE, hazards from welding In air contaminated with 51-0021 TRICHLOROETHYLENE, hazards of substitute chemicals for decaffeinated coffee 38-0025 TRICHLOROETHYLENE, health survey indicates its nontoxicity in letterpress room of printing company -25- ------- Ref. No. 33-0030 TRICHLOROETHYLENE, hepatotoxicity in rats 50-0021 TRICHLOROETHYLENE, Induces hepatocellular carcinoma in mice 41-0023 TRICHLOROETHYLENE, long-term Inhalation effects on mice and rats to be studied 28-0017 TRICHLOROETHYLENE, long-term inhalation effects to be studied 45-0026 TRICHLOROETHYLENE, measurement of metabolites in blood and urine following exposure to 33-0024 TRICHLOROETHYLENE, new proposed OSHA standards follow NIOSH and NCI alert of potential carcinogenicity 36-0026 TRICHLOROETHYLENE, occupational health aspects to be studied 50-0004 TRICHLOROETHYLENE, OSHA standards delayed 36-0025 TRICHLOROETHYLENE, OSHA's proposed health standard for 29-0013 TRICHLOROETHYLENE, persistence in natural water bodies 44-0024 TRICHLOROETHYLENE, photodecompositlon rates under simulated atmospheric conditions 38-0037 TRICHLOROETHYLENE, photooxidation reactivity and products 48-0026 TRICHLOROETHYLENE, possible source of atmospheric chloroform 32-0018 TRICHLOROETHYLENE, potential carcinogenicity prompts OSHA's proposed new occupational standard 44-0023 TRICHLOROETHYLENE, potential health hazard in PVC extruded hose manufacture 37-0028 TRICHLOROETHYLENE, potential health hazards under study 27-0020 TRICHLOROETHYLENE, presence in drinking water 50-0020 TRICHLOROETHYLENE, price rise of 1? as of July 1, 1976 35-0034 TRICHLOROETHYLENE, price to go up le/lb 51-0020 TRICHLOROETHYLENE, production increased 39-0021 TRICHLOROETHYLENE, survey indicates nontoxic hazard currently in coil manufacturing plant 33-0024 TRICHLOROETHYLENE, toxic effects on animals and humans 42-0010 TRICHLOROFLUOROMETHANE, adsorption on activated carbon 37-0016 TRICHLOROFLUOROMETHANE, concentrations in atmosphere measured by infrared 51-0009 TRICHLOROFLUOROMETHANE, effect on animals 36-0008 TRICHLOROFLUOROMETHANE, effects on tracheobronchial particle deposition and clearance in donkeys 40-0008 TRICHLOROFLUOROMETHANE, estimated stratospheric concentration of gaseous chlorine compounds 40-0009 TRICHLOROFLUOROMETHANE, stratospheric concentrations 40-0011 TRICHLOROFLUOROMETHANE, stratospheric profile 31-0012 TRICHLOROFLUOROMETHANE, ultraviolet photoabsorption 45-0017 TRICHLOROFLUOROMETHANE (F-ll), effect in preexisting heart disease 46-0017 TRICHLOROFLUOROMETHANE (FC-11), world production from start of commercial manufacture through 1975 set at 7,562 million Ib 36-0007 TRICHLOROMETHANE (CHLOROFORM), National Organics Reconnaissance Survey for halogenated organics 30-0016 TRICHLOROMONOFLUOROMETHANE, interactions with human and bovine globulins 30-0015 TRICHLOROMONOFLUOROMETHANE, solubility in blood and plasma of different species 42-0009 TRICHLOROMONOFLUOROMETHANE, solubility in dog blood and tissue homogenates 49-0006 TRl-o-CRESYL PHOSPHATE, biochemical mechanisms in delayed neurotoxlcity •47-0007 TRICRESYL PHOSPHATE, potential toxicity has practically eliminated its use in paints 43-0037 l,l,l-TRIFLUORO-N-I2-METHYL-4-(PHENYLSULFONYL)PHENYL]-METHANESULFONAMIDE, new cotton weed herbicide from 3M 36-0007 TRIHALOMETHANES, National Organics Reconnaissance Survey for halogenated organics 42-0014 TRIMETHYLHYDRAZINE HYDROCHLORIDE, tumor inducer in mice 45-0007 TRIMETHYLPHOSPHATE, sterility induced by exposure to 35-0009 TRIMETHYLPHOSPHITB, Mobil Chemical's new Charleston, S.C. plant should be onstream in 1977 35-0014 TRIS-1,2,3-(CHLOROMETHOXY)PROPANE, carcinogenicity in mice 45-0008 TRIS(2,3-DIBROMOPROPYL)PHOSPHATE, flame retardant may be carcinogenic 43-0009 TRIS(2,3-DIBROMOPRQPYL)PHOSPHATE, human contact sensitization 38-0008 TRIS(2,3-DIBROMOPROPYL)PHOSPHATE, toxicity to goldfish 44-0021 UNSYMMETRICAL DIMETHYLHYDRAZINE, acute and chronic toxicity experiments 36-0014 UNSYMMETRICAL DIMETHYLHYDRAZINE, FMC plant to shut down due to detection of dimethylnitrosamine, a toxic intermediate of the process 35-0037 UNSYMMETRICAL DIMETHYLHYDRAZINE, production from dinethylnitrosamlne (DMN) yields emission of potentially carcinogenic DMN in Baltimore air 36-0013 UNSYMMETRICAL DIMETHYLHYDRAZINE, production threatened due to emission of dimethvlnitrosamine (DMNA) 47-0048 URANIUM MILL WASTES, potential lung cancer hazard for the general public 37-0037 URETHAN, Inactive carcinogenic and mutagenic agent in hamsters 43-0027 URETHAN, mammary carcinogen in mice and rats 43-0027 URETHAN, model presents sequence of events in mouse mammary tumorigenesis 44-0026 URETHANE, effect on sperm abnormalities in mice 37-0027 URETHANE, foam chips useful for oil-spill cleanups 35-0023 URETHANE, genetic malformations in mouse limbs 44-0026 URETHANE, market demand in 1976 expected to rise 15% over the 1.41 billion Ibs in 1975 35-0022 URETHANE, teratogenesis and carcinogenesis in mice 50-0019 URETHANE, tumor susceptibility in various organs of mice 35-0024 URETHANE, ultrastructure of thymomas in rats 32-0017 URETHANE-COATED FABRICS, advantages over vinyl fabrics 42-0020 URETHANE COATINGS, flame retardant types for tenting materials 44-0022 URETHANE TRACKS, potential health hazard noted in factory producing tracks for snowmobiles 47-0025 URETHANES, new 25,000 sq ft manufacturing plant in Arlington, Texas is announced by M-R Plastics & Coatings, Inc. (St. Louis) 32-0013 URETHANES, significant Increase in worldwide consumption predicted over next decade 30-0010 UV STABILIZERS, market potential In plastics 33-0036 VANADIUM, bioaccumulatlon in marine species 35-0032 VINYL CHLORIDE, absorption spectra of metabolites 30-0040 VINYL CHLORIDE, activated carbon personnel monitoring system 34-0009 VINYL CHLORIDE, Allied Chemicas's Baton Rouge plant with annual capacity of 300 million Ib may be purchased by Roblntech Inc. 37-0033 VINYL CHLORIDE, analysis by gas-liquid chromatography in PVC, food solvents, etc. -26- ------- Ref. No. 44-0030 48-0028 35-0005 32-0022 32-0020 35-0035 40-0026 46-0044 35-0018 36-0001 43-0032 43-0030 44-0029 38-0027 31-0009 33-0028 43-0015 51-0022 36-0028 32-0021 42-0025 VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL CHLORIDE, CHLORIDE, CHLORIDE, CHLORIDE, CHLORIDE, CHLORIDE, CHLORIDE, CHLORIDE, CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, 27-0027 VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, 34-0009 VINYL CHLORIDE, 49-0029 44-0031 47-0026 40-0020 32-0022 46-0042 30-0041 36-0027 36-0031 52-0035 44-0028 32-0025 41-0001 49-0024 52-0036 46-0038 45-0029 49-0030 36-0029 33-0030 35-0005 37-0029 52-0034 39-0024 51-0024 51-0024 34-0007 43-0032 33-0029 36-0010 41-0024 29-0019 38-0007 35-0019 35-0032 31-0031 52-0035 41-0027 43-0002 30-0035 32-0024 32-0019 40-0022 37-0031 35-0033 VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE! VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, VINYL CHLORIDE, : VINYL CHLORIDE, analysis in air via microwave-induced discharges angiosarcoma found in worker exposed for the short time of 3.5 years animal studies useful in predicting human carcinogenic effects assessment of emissions control techniques and cost association of exposures with morbidity symptoms of polymerization workers B.F. Goodrich anticipates Industry capacity to grow by 40% by 1980 B.F. Goodrich research program has resulted in low levels of VCM in operations bibliography on toxlcity of by-product streams from VC plants can be used as feedstock in PPG Industries oxychlorination/oxyhydrochlorination process for manufacture of perchloroethylene- trichloroethylene carcinogenic to man chloroacetaldehyde suggested as carcinogenic metabolite community-based study in Charleston, V.Virginia planned to determine potential for causing birth defects computer model studies risk concentration in cigarette smoke corresponds to about 30 ppb contributor to effective flame retardant for polyester/cotton blends death from liver cancer of Japanese VC worker prompts Japanese national safety standard delay by FDA in setting migration levels for VC in food packaging materials attributed to need to study reported findings of ingested VC-caused cancer in rats detection in air determination of ambient air levels due to presence of polyvlnyl chloride products determination with charcoal tubes of airborne Diamond Shamrock may build monomer production plant Dow research indicates that body's glutathlone may handle a certain amount of monomer without toxlcological effect Dow's Freeport, Texas plant to be expanded by SOX increase to produce 330 million Ib/yr dynamic behavior in aquatic ecosystems dynamic behavior In aqueous ecosystems effects of liver extracts and free radicals on enhancement of the mutagenic effects of elimination of acetaldehyde Interference in gas chromatographic analysis emission points identified and quantified for four types of monomer production plants emission standard for EPA and HEW standards aimed at protecting people living near plants EPA assessment of environmental problems EPA proposed standards epidemiological review and evaluation of neoplastic effects in workers estimates of number of people living near VC and VC resin plants explosive potential in storage and in mixing operations exports in 1975 were about 414.6 million Ib or 0.5X more than in 1974 fate in rats following ingestion appears to be dose-dependent gas-chromatographlc determination in workplace air samples collected on charcoal genetic effects induced by genetic effects of genetic risks of Goodrich meets safety rules hepatotoxicity in rats human and animal carcinogen if EPA's proposed air emission standards are adopted four small PVC plants may have to close Inadequacy of protection for industrial exposure industry is prepared to accept EPA standards for regulating air emissions from VC olants induction of metabolism of inhibition of metabolsim of industry moved quickly to prevent future carcinogenic hazards liver cancer in Yugoslavian PVC workers market should remain strong despite adverse publicity and competitive materials monitoring with a portable mass spectrometer mutagenic and carcinogenic effects reviewed mutagenic effects mutagenic potency mutageniclty mutagenlclty and carcinogenicity research study mutagenlcity of a possible metabolite neoplastic risk among workers exposed to new air emission standards proposed by EPA will cost 20 PVC producers $183 million new plants under construction by Diamond Shamrock and Dow Chemical new polyester food packaging material will compete with rigid PVC blister packaging nine angiosarcoma deaths reported in one Canadian PVC plant no evidence of cocarcinogenic effect of this monomer found in mice Implant studies not currently a health hazard in PVC pipe manufacturing plant not seen as health hazard in mortality study of Welsh workers Olln Corp. plans new chlor-alkali unit for 1978 to meet anticipated chlorine demand based on optimistic predictions for improving VC market -27- ------- Ref. No. 52-0033 28-0024 37-0032 37-0032 42-0024 49-0026 38-0029 30-0037 40-0019 32-0023 44-0024 38-0037 37-0030 29-0018 40-0021 VINYL VINYL VINYL VINYL VINYL VINYL VINYL -VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL 38-0027 VINYL 40-0021 49-0007 44-0023 49-0002 33-0027 40-0023 40-0024 42-0005 48-0033 30-0036 48-0002 46-0003 46-0040 46-0041 49-0025 40-0025 48-0031 32-0026 49-0023 42-0003 48-0029 28-0019 48-0030 •52-0032 34-0009 52-0031 37-0034 52-0036 39-0025 44-0032 49-0027 37-0029 49-0023 33-0026 51-0023 43-0032 42-0022 43-0031 38-0034 34-0010 44-0034 44-0033 51-0023 31-0032 48-0027 35-0035 35-0026 35-0028 VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL VINYL- VINYL VINYL CHLORIDE, oneogenic and mutagenic risks in communities with PVC production facilities CHLORIDE, one of 13 carcinogens for which OSHA has published health standards CHLORIDE, oral dose not yet linked to angiosarcoma CHLORIDE, overview of TOA studies re: carcinogenicity CHLORIDE, overview on worker protection CHLORIDE, patents disclose means of removing residual monomer from PVC resins CHLORIDE, percutaneous absorption CHLORIDE, personnel protection methods CHLORIDE, pharmacodynamics and uptake by rats CHLORIDE, photochemical reactivity CHLORIDE, photodecompositlon rates under simulated atmospheric conditions CHLORIDE, photooxidation reactivity and products CHLORIDE, possible cause o£ congenital malformations CHLORIDE, potential cause of heart and cardiovascular diseases CHLORIDE, potential cause of miscarriages or stillbirths In spouses of men exposed to VCM at work CHLORIDE, potential emission from burning of plants and other organic materials containing chlorine CHLORIDE, potential hazard to sperm cells of men exposed to it at work CHLORIDE, potential health hazard in paints CHLORIDE, potential health hazard in PVC extruded hose manufacture CHLORIDE, potential health hazards when used as a polymer raw material CHLORIDE, potential teratogen CHLORIDE, potentially hazardous levels in plant manufacturing PVC backed material CHLORIDE, potentially toxic levels in a forge manufacturing hand tools CHLORIDE, presence in Kentucky school laboratories indicates need for schools to enforce safety standards for exposure CHLORIDE, price increase announced by Conoco CHLORIDE, process for removing VCM from polymer resin CHLORIDE, production drop in 1975 CHLORIDE, production in 1975 dropped to 4.20 billion Ib compared to 5.62 billion Ib in 1974 CHLORIDE, production of ethylene in 1976 may top previous high of 1974 CHLORIDE, proposed standard to reduce allowable emissions of CHLORIDE, recommended procedures for disposal of aerosol cans CHLORIDE, recommended standard for occupational exposure to CHLORIDE, review of carcinogenic potential CHLORIDE, review of known toxic, biological and carcinogenic effects raises question of yet unknown hazards CHLORIDE, review of monomer health problem CHLORIDE, review of recent court cases indicates court's view of importance of reciprocal relationship between risk and harm in judging toxlcity CHLORIDE, review of use in production of PVC, animal studies, and human health effects CHLORIDE, rise in production stimulates ethylene production CHLORIDE, risk to consumers and PVC workers from CHLORIDE, Robintech Inc. expected to buy Allied Chemical's VCM plant near Baton Rouge, Louisiana CHLORIDE, Robintech Inc. seeks additional capacity by buying existing plant CHLORIDE, Robintech's new process of "m-kettle compounding" during polymerization results in a more porous polymer in about 20% less time CHLORIDE, Russians expanding monomer capacity CHLORIDE, sampling and analysis in workplace air CHLORIDE, sampling and analysis techniques CHLORIDE, scientific and technical assessment of health hazards and environmental factors CHLORIDE, skin disease changes in exposed workers may give early warning of VC disease and offer model for studying scleroderma CHLORIDE, SPI questions necessity of EPA's proposal to classify VC as hazardous air pollutant CHLORIDE, steps taken in the UK to contain monomer health problem CHLORIDE, structure and mechanism of thermal degradation of some condensation polymers CHLORIDE, survey of exposure in processing plants, state of Washington CHLORIDE, Swedish workers show fourfold excess of liver-pancreas deaths CHLORIDE, systems and equipment Installed by B.F. Goodrich and Robintech to meet OSHA 'a occupational exposure standards CHLORIDE, two birth defects studies planned CHLORIDE, Union Carbide will shut down Its vinyl dispersion resins plant at South Charleton, W. Virginia at end of 1976 CHLORIDE, Uniroyal Chemical is stopping production of all PVC resins at Palnesville, Ohio plant because of high cost of environmental controls CHLORIDE, use of oxygen rather than air In the oxychlorination VCM process offers economic and environmental advantages particularly for new plants CHLORIDE, use of oxygen seen more effective than air in the oxychlorination step of the balanced oxychlorination VCM process CHLORIDE, Washington State Department of Labor and Industries adopts standard June 6, 1975 CHLORIDE, workplace emissions satisfactorily monitored at Georgia Pacific's Plaquemlne, La. plant CHLORIDE DISEASE, immunologlcal mechanisms in its pathogenesls CHLORIDE M3NOMER, B.F. Goodrlch's R&D program results will cut cost of meeting OSHA's emissions limits by 1977 CHLORIDE MONOMER, description of B.F. Goodrich process for manufacture from ethylene, chlorine, and air CHLORIDE MONOMER, description of Monsanto-Sclentific Design Co. , Inc. process for manufacture from ethylene, chlorine, air or oxygen -28- ------- Ref. No. 35-0027 VINYL CHLORIDE MONOMER, description of PPG Industries process for manufacture from ethylene, oxygen, chlorine and HC1 36-0030 VINYL CHLORIDE MONOMER, Diamond Shamrock to build 1-bllllon Ibs/year plant at Its LaPorte, Texas complex 28-0021 VINYL CHLORIDE MONOMER, emissions from PVC resins reduced by new stripping process 35-0030 VINYL CHLORIDE MONOMER, Firestone Plastic Co.'s new Perryville, Md. PVC resin plant set to meet OSHA emission standards and EPA residual content limits 29-0016 VINYL CHLORIDE MONOMER, genetic effects in humans and animals 29-0015 VINYL CHLORIDE MONOMER, industry and Health Research Group at odds over PVC packaging ban for foods proposed by FDA 27-0024 VINYL CHLORIDE MONOMER, mid-1975 production well below mid-1974 output 30-0038 VINYL CHLORIDE MONOMER, monitoring and control for tank trucks and other transport vehicles 27-0023 VINYL CHLORIDE MONOMER, new Gerogia-Pacific PVC plant is in compliance with OSHA's future 1 ppm standard 38-0033 VINYL CHLORIDE MONOMER, possible mid-1976 shortage due to increased PVC capacity and lack o£ VCM capacity expansion 38-0028 VINYL CHLORIDE MONOMER, potential chronic toxicity/carcinogenicity of VCM given orally to rats 38-0033 VINYL CHLORIDE MONOMER, price increase of 1.6«/lb announced 35-0034 VINYL CHLORIDE MONOMER, price will rise to 12.6c/lb in early 1976 31-0030 VINYL CHLORIDE MONOMER, production procedures •39-0026 VINYL CHLORIDE MONOMER, properties, handling, analysis 30-0036 VINYL CHLORIDE MONOMER, reduction and control 30-0039 VINYL CHLORIDE MONOMER, stripping techniques for removal from PVC resins 46-0039 VINYL CHLORIDE POISONING, incidence of in workers 32-0019 VINYL CHLORIDE VINYL ACETATE COPOLYMER, tumors in mice induced by presence of foreign body implant 30-0040 VINYLIDENE CHLORIDE, activated carbon personnel monitoring system 33-0031 VINYLIDENE CHLORIDE, capacity increase via expansion of PPG's Lake Charles, Louisiana facility 37-0002 VINYLIDENE CHLORIDE, copolymer with acrylonitrile as possible T102 substitute in papermaking 29-0019 VINYLIDENE CHLORIDE, mutagenic effects 38-0007 VINYLIDENE CHLORIDE, mutagenic potency 47-0027 VINYLIDENE CHLORIDE, new PPG plant expansion at Lake Charles, La. will double production of monomer 44-0024 VINYLIDENE CHLORIDE, photodecompositlon rates under simulated atmospheric conditions 38-0037 VINYLIDENE CHLORIDE, photooxidation reactivity and products 37-0035 VINYLIDENE CHLORIDE, potential cause of liver Irregularities in New Jersey workers 49-0002 VINYLIDENE CHLORIDE, potential health hazards when used aa a polymer raw material 46-0051 52-0026 WASTES, disposal of toxic and hazardous WATER QUALITY MODEL, simulating concentration distributions for coupled constituents 29-0003 XENYLAMINE, potential bladder carcinogen 45-0031 ZIRCONIUM, hazards from use in antiperapirant sprays -29- ------- AUTHOR INDEX 32-0001 47-0004 47-0021 30-0006 46-0030 27-0007 37-0008 36-0008 44-0035 46-0014 31-0015 39-0018 38-0041 37-0008 49-0005 31-0031 38-0007 38-0052 32-0001 29-0016 27-0010 43-0008 46-0003 44-0007 45-0024 45-0028 41-0012 45-0038 48-0010 34-0004 52-0001 46-0039 41-0007 34-0004 48-0025 51-0010 52-0004 47-0029 52-0015 40-0030 49-0034 40-0030 49-0034 36-0010 34-0004 47-0038 45-0026 47-0021 46-0032 49-0013 31-0022 45-0014 38-0035 30-0008 43-0004 47-0040 31-0010 37-0039 48-0023 45-0005 41-0028 30-0026 52-0028 46-0038 35-0032 45-0038 46-0038 30-0039 51-0013 52-0018 33-0012 35-0031 35-0032 41-0024 51-0011 46-0038 38-0002 27-0001 40-0033 41-0007 47-0009 39-0001 51-0001 38-0045 ABDELGHANI, A. A. ACKERMAN, Evelyn R. ADAMS, V.D. AFTOSMIS, James G. AHNER, David J. AIMMERMAN, Stephen W. ALARIF, A. ALBERT, R.E. ALDRIDGE, W.N. ALLARA, D.L. ALLEN, Sylvester T. ALLEY, Earl G. ALTHOFF, Jurgen AMACHER, D.E. AMASA, S.K. AMES, Bruce N. AMSTER, Robert L. ANDERSON, A.C. ANDERSON, D. ANDERSON, Earl V. ANDERSON, H. ANDERSON, H.F. ANDERSON, H.W. ANDERSON, Kurt ANDRASCH, R.H. ANGIONE, Ronald J. ANTELL, M. ANTOINE, A.D. ANTONYUZHENKO, V.A. ANVER, M.R. APPLEBY, Alan APPLEYARD, A.J. ARBOGAST, B.L. ARCHER, Michael C. ARCHER, V.E. ARCOS, Joseph C. ARGUS, Mary F. ARNOLD, James T. ARNTS, 8. ASPHALT INST. ASTRAND, I. AUSTRHEIM- SMITH, S. AUTIAN, J. AVIADO, Domingo M. AYER, Franklin A. AZAR, A. BABA, Theodore B. BABISH, John G. BACHE, Carl A. BACK, Kenneth C. BADGER, James H. BAHNER, Barbara BAKER, J.H. BALAAM, L.N. BALDWIN, Jack E. BALL, D. BANERJEE, S. BARALE, R. BARBIN, A. BARDANA, E. BARONCELLI, S. BARR, J.T. BARTELL, C.K. BARTON, I.J. BARTSCH, Helmut BATEMAN, P.E. BAUER, C. BEAMAN, D.R. BEATTY, J.R. BEAUCHINGER, M. BEAUDOIN, A.R. BECKER, D.A. BECKLAKE, M.R. BECKMAN, William A. 51-0003 48-0023 27-0038 27-0003 34-0012 27-0007 49-0036 30-0037 36-0007 38-0020 32-0036 52-0037 47-0002 49-0008 48-0038 33-0016 31-0036 40-0034 52-0038 36-0028 48-0026 44-0011 44-0018 30-0034 28-0016 31-0004 30-0028 52-0006 39-0022 39-0021 50-0013 37-0043 42-0024 34-0014 40-0022 40-0003 36-0008 29-0019 51-0024 29-0019 51-0024 38-0038 33-0020 35-0019 30-0030 30-0014 50-0008 46-0021 33-0005 44-0015 37-0003 32-0019 32-0019 27-0036 30-0028 41-0028 31-0025 37-0033 44-0024 •48-0007 35-0032 44-0028 35-0046 46-0038 39-0002 44-0001 44-0010 46-0049 39-0018 37-0033 40-0004 43-0024 30-0047 42-0001 35-0016 37-0009 47-0006 38-0027 40-0030 49-0034 51-0024 38-0037 39-0016 39-0017 BEDDOWS, N.A. BEDINGER, C.A. , Jr. BEECHEY, C.V. BEEGLE, Robert G. BEIL, Karen M. BEIRNE, Gregory J. BELCHER, N.M. BELL, Z.G. , Jr. BELLAR, Thomas A. BENDER, Edward S. BERG, John W. BERKLEY, R.W. BERRY, G. BERRY, J.P. BETTERIDGE, D. BEYCHOK, Milton R. BIDLEMAN, T.F. BIESINGER, Kenneth E. BILLS, D.D. BIRCH, Shelton R. BIR SINGH, Hanwant BITMAN, J. BLACK, R.F. BLANCHFIELD, Burke J. BLANCK, M.D. BLASZAK, Thomas P. BLAU, G.E. BLEJER, H.P. BLINOVA, E.A. BLOOM, T.F. BOBOTAS, G. BOCK, Fred G. BODEN, Leslie I. BODINE, Steven R. BODNER, Arnold H. BOHN, Arne BOHNING, D.E. BOLT, H.M. BOLT, W. BOND, E.J. BONSE, G. BOOTH, Gary M. BOOZ, Charles S. , Jr. BORISOV, A.I. BORYS, Randolph D. BOSTICK, D.T. BOUHUYS, A. BRAMAN, Robert S. BRAND, Inge BRAND, K. Gerhard BRANDT, M. BRANSON, D.R. BRANZ, Stephen E. BRATT, H. BREDER, Charles V. BREDEWEG, Corwln J. BREEDIN, Patricia H. BRESIL, H. BRIHKMAN, Charles P. BROENKOW, W.W. BRONZETTI, G. BROOKER, James R. BROWN, H.R. BROWN, K.W. BROWN, Lewis R. BROWN, Margaret E. BROWN, Martha M. BROWN, Robena J. BROWN, Stephen M. BROWN, V.M. BRUCE, W.R. BRUCKMAN, Leonard BRUNNEMANN, Klaus D. BRYANT, Georgia M. BUCHTER, A. BUFALINI, Joseph J. BULL, Don L. -30- ------- 52-0037 46-0009 32-0019 36-0028 42-0024 30-0044 46-0036 27-0031 42-0030 52-0037 41-0005 46-0046 48-0006 31-0012 48-0007 35-0004 40-0022 40-0023 40-0024 39-0019 40-0030 31-0026 37-0045 45-0012 46-0038 43-0025 27-0020 49-0014 32-0022 38-0049 48-0031 36-0007 37-0031 45-0006 32-0006 33-0026 33-0039 44-0011 31-0012 46-0038 41-0011 33-0022 33-0023 38-0022 30-0039 49-0032 42-0009 42-0010 37-0020 44-0017 27-0009 46-0051 48-0031 30-0015 30-0016 42-0009 42-0010 42-0011 38-0014 38-0007 37-0015 49-0035 52-0034 44-0006 40-0016 47-0039 47-0039 28-0003 40-0008 40-0029 49-0019 31-0010 28-0016 52-0011 31-0038 39-0006 46-0029 30-0001 44-0016 36-0008 43-0021 40-0029 51-0013 38-0027 39-0018 37-0031 BUNCH, J.E. BUNIMOV1CH, G.I. BUOEN, Lance C. BURG, William R. BURGESS, William A. BURKE, Donald P. BURKE, Hubert D. BURNETT, C. Clyde BURSEY, J.T. BUSCH, R.H. BUSHNELL, David L. BUSS, David H. BUTLER, Frank E. BUTLER, George J. BUTTON, Lawrence N. BUU-HOI, Nguyen Ph CAASI, Priscilla I. CALABRESE, Edward J. CALANDRA, J.C. CAMMELLINI, A. CAPEROS, Jose R. CARLISLE, Douglas R. CARLSON, Gary P. CARPENTER, Ben H. CARPENTER, C.P. CARRETTI, Donate CARSWELL, Keith J. CARTER, J.T. CARTER, L.J. CARTON, Robert J. CASCAVAL, C.N. CAS ID A, John E. CECIL, B.C. CELOTTA, R.J. CERCIGNANI, G. CHAMEIDES, William L. CHAN, U.S. CHAN, R.K.S. CHAN, W.C. CHANG, Kun CHANG, Louis W. CHARLESWORTH, F.A. CHEREMISINOFF, Paul N. CHIECO, P. CHIOU, Win L. CHERONIS, Nicholas P. CHOI, Edmund CHOU, C.C. CHOW, Y..L. CHRISTIANI, D.C. CHRISTIANSON, Charles CKROSTEK, Walter J. CHUGH, Y.P. CHURCH, J. CHYNOWETH, David P. CICERONE, R.J. CLAPP, N. CLARK, B.R. CLARK, Kirtland P. CLARY, J.J. CLAYSON, D.B. CLEMENS, Thomas L. COBB, Donald A. COCHRAN, Neal P. CODDING, C.N. COHEN, Burton M. COHEN, V.R. COLWELL, Rita R. COLYER, S. CONDIE, D.B. CONSTANTIN, Patrlanakos COOK, David W. COOMBES, E.J. 43-0016 31-0001 31-0002 43-0022 41-0007 40-0016 50-0003 41-0007 46-0038 37-0021 48-0015 43-0016 47-0021 31-0023 51-0009 32-0023 45-0016 41-0005 51-0014 35-0044 32-0008 39-0039 46-0044 52-0040 35-0032 39-0021 30-0001 40-0009 36-0028 37-0037 40-0005 45-0024 31-0025 48-0027 39-0030 37-0010 37-0011 41-0002 49-0034 42-0016 47-0040 38-0012 43-0036 48-0013 38-0028 28-0028 52-0004 36-0007 52-0037 37-0033 45-0016 28-0020 42-0023 39-0029 39-0004 38-0016 52-0001 29-0013 44-0024 37-0037 50-0007 28-0013 43-0033 27-0003 43-0034 31-0009 51-0010 51-0007 38-0043 44-0009 42-0013 31-0023 27-0020 37-0007 49-0021 31-0009 52-0019 40-0033 45-0017 46-0021 48-0004 37-0031 37-0020 44-0017 38-0045 38-0038 COPELAND, M.F. COPENHAVER, E.D. CORBETT, T.H. CORNER, John W. CORN, Morton CORNELL, R.G. CORSI, C. COULSTOS, Frederick COURTNEY, K. Diane COWAN, P. A. COX, Kenneth E. COX, P.J. COX, R.A. CRAIG, O.K. CRARY, D.D. CREASIA, D.A. CRIST, Howard L. CROCKETT, Pernell W. CROISY, A. CROMER, J. CROSS, Frank L. , jr. CRUTZEN. P.J. CUDDEBACK, John E. CUDDY , Rosemary CUNNINGHAM, H.M. DAHLBERG, J.A. DANIEL, J.W. DARKE, C.S. DaSILVA, Luiz H. Pereiri DASSONVILLE, J. DATTA, D.V. DAVIES, D.L. DAVIS, B.E. DAVIS, Richard A. DEAN, Brenda J. DEEN, Dennis DcFONSO, Lester R. DeGROOT, A. P. DEINZER, M. DeMARCO, Jack DeMAKRAIS, G.A. DENNISON, Lawrence J. DERWENT, R.G. DESAI, Rashmlbala DeSERRES, F.J. DIAMONDSTONE, B.I. DICKSON, Edward M. DiGERONIMO, M.J. DILLING, Wendell L. D1PAOLO, Joseph A. DIXON, R.L. DOBNER, Samuel DODSON, B. DOHNER, V. Alton DONALDSON, Barbara DONALDSON, D.J. DONIACH, D. DONOVAN, R.J. DOOLEY, C.J. DOOLEY, Kenneth DOST, F.N. DOWNS, W. Richard DOWTY, Betty J. DOYLE, Susan G. DRAGGAN, S. DRAKE, G.L., Jr. DREIFUSS, P. A. DRESP, J. DREW, R.T. DUCE, Robert A. DUCK, B.W. DUDLEY, Alden W. , Jr. DUFFIE, John A. DUMAS, T. -31- ------- 48-0003 30-0020 39-0001 45-0007 38-0036 46-0037 42-0016 38-0041 52-0005 44-0003 37-0030 51-0026 32-0023 45-0016 40-0011 41-0029 31-0020 40-0033 27-0032 42-0007 51-0012 28-0029 40-0015 27-0012 36-0001 39-0002 40-0032 46-0047 41-0007 30-0026 32-0001 31-0027 41-0004 49-0015 46-0042 36-0027 49-0019 37-0006 37-0008 49-0036 46-0037 48-0028 37-0007 36-0010 51-0012 45-0007 32-0027 42-0024 29-0010 49-0017 37-0030 45-0027 45-0029 49-0030 32-0028 48-0037 48-0004 52-0039 44-0033 30-0007 40-0009 38-0043 35-0011 39-0006 40-0009 43-0025 38-0028 28-0015 50-0013 48-0019 38-0043 46-0039 38-0002 44-0036 33-0033 49-0036 52-0037 39-0029 38-0046 52-0026 47-0003 46-0022 49-0032 27-0017 27-0018 27-0019 DUPUY, A.E., Jr. DURKIN, Patrick R. DURST, R.A. DWIVEDI, C. DWYER, F.G. DYER, Robert F. DZUNA, E.R. EAGEN, Michael DATOUGH, D.J. ECKERT, Herbert L. EDMONDS, Larry D. EGERT, G. EGGLETON, A.E.J. EHHALT, D.H. EHRENBERG, L. EICHENAUER, Max G. EINBRODT, H.J. EISENBRAND, G. ELDEFRAWI, M.E. ELDER, G.H. ELDREDGE, J.D. ELKORT, R.J. ELLZEY, V.W. EMBER, Lois EMERSON, John A. EMMELOT, P. EMMINGER, Eberhard ENDRES, J. ENGDAHL, R. ENGLANDE, A.J., Jr. ENG-LIANG, Cheu ENTERLINE, Philip E. ENVIRONMENTAL PROTECTION AGENCY OFFICE OF TOXIC SUBSTANCES EPA, OFFICE AIR QUALITY PLANNING & STANDARDS EPA WASHINGTON, D.C. EPLER, J.L. EPSTEIN, S.S. ESCH, Victor H. EVANS, D.M.D. EVANS, J.C. EVANS, Joseph E. EVANS, J.O. EVANS, M.A. EXON, J.H. FAEGER, Rudolph F. FAIRCHILD, M.D. FALK, H. FALK, H.L. FARBER, John L. FASCHING, James L. FAZIO, T. FEATHERS, R.E. FEHRINGER, Norbert V. FEHSENFELD, F.C. FEINBERG, J.I. FERBER, G.J. FERBER, Kelvin H. FERGUSON, E.E. FERNANDEZ, J. FERON, V.J. FEY, Willard R. FIALA, Emerich S. FICKE, Hunter H. FIDDLER, W. FILATOVA, V.S. FILE, D.M. FINCHER, Robert C. FINE, David H. FISHER, C.R. FISHER, Nicholas S. FLAKE, R.H. FLIGIEL, Zuzana FOLEY, H.M. FONG, Y.Y. FORBES, P.O. 30-0042 48-0003 44-0038 27-0012 40-0004 47-0007 37-0043 51-0014 44-0018 35-0039 45-0013 41-0016 39-0011 49-0031 44-0011 27-0036 36-0024 44-0009 43-0036 52-0026 37-0006 51-0015 48-0020 43-0004 33-0008 32-0020 38-0042 27-0016 37-0025 32-0011 39-0004 46-0030 40-0035 47-0026 48-0029 38-0037 38-0049 41-0009 32-0004 38-0029 45-0025 49-0024 30-0005 52-0017 29-0011 27-0021 46-0038 43-0019 33-0022 33-0023 38-0022 45-0004 28-0029 39-0001 27-0031 31-0020 39-0027 51-0022 48-0015 37-0021 40-0009 35-0014 43-0020 40-0028 41-0028 49-0017 44-0036 31-0021 40-0004 39-0011 48-0015 46-0014 28-0013 38-0041 33-0013 28-0019 27-0038 31-0007 42-0028 44-0006 52-0008 27-0014 48-0017 35-0019 51-0026 37-0013 37-0014 FORD, Dennis FOREHAND, T.J. FORNI, Alessandra FOSTER, J.F. FOWLER, Bruce A. FOX, A.J. FOX, Helen W. FOX, R.R. FRANKEL, L.S. FRANTZ, C.N. FREY, J.J. FRIDOVICH, Irwin FRIEDMAN, Alan R. FRIEDMAN, M.A. FRIES, G.F. FRIFFING, M.E. FRISCH, K.C. FRITH, Charles H. FRITZ, Steven FRUH, E.G. FU, M.M. FU, Y.C. FUMICH, George, Jr. FURR, A. Keith GADIAN, Theodore GAMBLE, John GANGOLLI, S.D. GANZ, Charles R. GARMAISE, Annie B-K GARN, P.O. GARRITY, John J. GARRO, Anthony J. GAUVAIN, Suzette GAY, Bruce W. , Jr. GEARY, D.L., Jr. GECHEFF, K. GEHRING, Perry J. GEHRKE, Charles W. GEIKE, F. GEORGE, Marilyn E. GERRISH, Sarah Lee GERVASI, G. GETZ, L.L. GIAM, C.S. GIBBS, G.W. GILLESPIE, D.M. GILLS, T.E. GIOVACCHINI, R. GOERZ, Gunther GOING, John GOLBERG, L. GOLDBERG, Leon GOLDMAN, P.O. GOLDSCHMIDT, Bernard M. GOLDSMITH, John R. GOLUB, N.I. GOMEZ, Reinaldo F. GOODMAN, S.J. GORDON, John A. GORMLEY, William T. GOYER, Robert A. GRABER, David R. GRACE, U.K. GRAEDEL, T.E. GRAFF, Robert A. GRANDJEAN, Carter GRANT, D.L. GREEK, Bruce F. GREEN, D. GREEN, G.H. GREEN, M.H.L. GREENBERG, Donald GREENBERG, S.D. GREENBLATT, M. GREENHOUSE, G. GREIM, H. GRIMSRUD, E.P. -32- ------- 27-0007 43-0025 49-0019 41-0006 46-0009 34-0004 39-0003 44-0022 44-0023 41-0006 46-0009 30-0008 38-0008 28-0015 47-0026 41-0032 39-0002 42-0016 34-0004 44-0003 46-0054 30-0002 32-0026 27-0012 41-0029 51-0011 38-0022 43-0039 30-0023 40-0015 43-0019 34-0004 52-0005 37-0016 38-0037 45-0007 38-0003 39-0014 40-0009 39-0013 35-0024 28-0002 31-0004 48-0038 35-0036 32-0028 52-0039 43-0014 33-0035 38-0042 46-0053 30-0006 32-0004 38-0029 40-0011 39-0013 40-0009 49-0002 49-0008 33-0020 35-0019 48-0037 29-0008 37-0012 28-0020 35-0041 41-0032 44-0031 37-0022 52-0036 31-0038 39-0006 42-0003 46-0027 50-0014 30-0029 48-0041 49-0019 32-0035 38-0027 46-0051 37-0007 47-0021 51-0013 31-0006 46-0053 GROEHLER, Ken GUBERAN, Etienne GUERIN, M.R. GULEVSKAYA, M.R. GUMPERT, R. GUNTER, Bobby J. GUSELNIKOVA, N.A. GUTENMANN, Walter H. GUTIERREZ, Luis T. GUTTENPLAN, J.B. HAAS, H. HACKLEY, Betty M. HAEBIG, Jon E. HAGUE, R. HAHON, Nicholas HAKE, Carl L. HALEY, Thomas J. HALL, E.H. HALLSTROM, I. HALSEY, M.J. HAMMARGREN, T.F. HAMMOND, Allen L. HAMMOND, Ogden HANDLER, A.H. HANEY, Alan HANSEN, David HANSEN, L.D. HANST, Philip L. HARBISON, R.D. HARRISON, Elizabeth A. HARROP, W.J. HART, F.L. HARUMI, Suzuki HARWOOD, Colin F. HASANUDDIN, Syed Khaja EASE BE, Kiyoshi HASEMAN, J.K. HAVERY, D.C. HAYES, Wayland J. HAYNIE, F. HEADING, Christine E. HEALY, Kristine M. HEBERT, Richard R. HEFNER, Robert E., Jr. HEIDI, L.E. HELFGOTT, T. HENDERSON, W.R. HENNING, H.F. HENOC, P. HENSCHLER, D. HERZOG, John HESTER, Norman E. HEXT, P.M. HILFRICH, Jom HILL, James IV HILL, Kenneth R. HILL, R.H. HILL, R.N. HILL, William J. HILLS, John P. HINSON, J.A. HIRSCH, B.F. HIRWE, Asha S. KITTLE, Douglas C. HO, C.H. HOEL, David G. HOFFMANN, Dietrich HOLCOMB, William F. HOLMES, A. HOLMES, W.F. HOLMQUIST, D.G. HOLT, Buford R. HOOK, Ernest B. 43-0009 37-0007 30-0020 27-0002 32-0036 32-0029 47-0029 35-0031 43-0019 51-0006 31-0012 33-0033 38-0016 27-0038 41-0014 44-0006 52-0008 52-0008 41-0008 41-0010 50-0011 35-0029 43-0029 47-0045 49-0009 46-0024 41-0013 31-0005 35-0003 51-0015 47-0041 45-0029 49-0030 52-0033 49-0008 31-0020 40-0009 50-0012 27-0028 39-0016 39-0017 48-0023 44-0037 39-0019 44-0004 35-0032 33-0030 34-0005 43-0034 39-0022 38-0021 39-0020 52-0039 45-0028 37-0003 35-0045 49-0006 52-0015 47-0019 47-0018 52-0035 31-0006 45-0002 46-0048 45-0034 42-0027 30-0025 29-0013 48-0014 52-0019 47-0003 47-0005 29-0019 51-0024 27-0036 45-0014 35-0003 37-0020 44-0017 48-0019 51-0007 42-0027 28-0006 34-0004 49-0037 HORNBERGER, Carl HOUNAM, R.F. HOWARD, Philip H. HOWARTH, Cynthia HOWELL, Margaret A. HOYLE, Harold R. HSEIH, Shul-Tien HUBERMAN, Eliezer HUDSON, J.L. HUEBNER, Russell H. HUFFMAN, Fred HUGHES, Evan E. HUMPHREYS, E.R. HUNTER, Byron A. HURST, George A. HURST, I.J. HUTZINGER, 0. IAMMARTINO, Nicholas R. IARC Working Group IATROPOULOS, M.J. I CUE, Basil U.N. IIJIMA, S. ILLIG, E.G. ILLINOIS INSTITUTE FOR ENVIRONMENTAL QUALITY INFANTE, P.F. ING, P. Galle IPPEN, Hellmut ISAKSEN, I.S.A. ISSENBERG, Phillip IVANKOVIC, S. IVIE, G. Wayne IVY, J.T. IZZAT, Ara JACOBSON, May S. JACOBY, F. JACQUIGNON, P. JAEGER, Rudolph JAFFE, Richard J. JAGANNATH, R. lyengar JANES, H. JAQUES, L.B. JELLINEK, H.H.G. JOE, F.L. JOHNSON, C.J. JOHNSON, David L. JOHNSON, Larry D. JOHNSON, M.K. JOHNSON, W.M. JOHNSON, William S. JONES, D. JONES, J. JONES, Jerry L. JONES, J.S.P. JONES, Robert N. JORDAN, J.W. KAKIZOE, Tadao KALFADELIS, C.D. KALLOS, George J. KAMPS, L.R. KANEKO, Mamoru KANTZ, Marcus E. KAPPUS, H. KAPRON. N. KARRH, B.W. KATSUNUMA, H. KATZ, Jordan KATZER, James R. KAUFMANN, K. KAWACHI, Takashl KAY, A.M. KAZAZIS, John KEELER, P. A. -33- ------- 45-0039 48-0013 45-0012 38-0035 45-0012 39-0019 32-0007 27-0012 37-0001 49-0010 47-0023 50-0014 50-0015 32-0002 38-0049 51-0009 38-0049 40-0036 50-0030 32-0035 28-0014 33-0006 43-0009 52-0039 52-0016 30-0003 41-0032 47-0028 39-0002 41-0006 46-0009 46-0010 47-0018 39-0033 40-0028 32-0027 44-0031 46-0026 37-0036 47-0039 39-0011 42-0012 46-0026 41-0034 41-0028 47-0029 39-0021 36-0023 48-0039 45-0013 40-0020 42-0019 36-0007 50-0008 52-0037 50-0013 31-0012 30-0047 30-0031 30-0037 45-0013 37-0036 38-0042 42-0008 35-0004 52-0004 44-0028 27-0005 43-0007 32-0029 27-0031 37-0011 51-0011 39-0025 43-0019 30-0030 38-0004 27-0020 51-0013 52-0018 30-0022 48-0015 51-0013 52-0018 36-0017 37-0006 44-0025 KEEN, R.C. KELTON, Stanton C. KENNEDY, G.L. KENNEDY, James R. KEPLINGER, M.L. KEVY, Sherwin V. KHUDOLEY, V.V. KIANG, K.D. KIEFER, David M. KILBEY, Brian J. KIM, S.W. KIMBALL, R.F. KING, H.G. KING, J.M. KING, L.J. KINKEAD, E.R. KIRKLAND, D.J. KIRSCHSTEIN, Ruth L. KLASS, Donald L. KLEMMER, H.W. KLIGMAN, Albert M. KLINE, D.A. KLINGEBIEL, U.I. KLOSTERKOTTER, Werner KMOCH, N. KNOBL, George M. KOGAN, F.M. Jr. KOHLI, J. KOHN, Philip M. KOLESNICHENKO, T.S. ROLLER, L.D. KOLLIG, Heinz P. KORANSKY, W. KOROPATNICK, D.J. KOS, D.W. KOSHY, K. Thomas KOSS, G. KRAFFT, S. KRAFT, Patricia L. KRAMKOUSKI, R.S. KRAWIEC, Robert G. KREFFT, Gerda B. KREY, P.W. KRISHEN, Anoop KRISHMAN, Sundaram KROPP, Kenneth L. KROSOVSKII, G.N. KROST, K. KULAKIS, C. KUYATT, C.E. KWOK, Linda V. LACAZE, Jean-Claude LAFLEUR, J.C. LAGOMARSINO, R.J. LAISHES, B.A. LAKE, B.C. LAMB, Brian K. LAMBERT, Joseph P. LAMBERTON, J.G. LANDAU, Emanuel LANGER, A.M. LANGNER, Ralph R. LANMAN, B. LANOE, J. LANSDOWN, A.B.C. LAO, R.C. LARIMORE, R.W. LARSEN, J.R. LARS EN, Lee B. LASETER, John L. LaSHELLE, John R. LASKA, Anthony L. LASSITER, Ray R. LAVAPPA, K.S. LAWRENCE, John 46-0032 41-0031 27-0035 31-0010 43-0013 44-0008 49-0041 47-0023 50-0007 30-0006 36-0020 38-0051 37-0020 48-0031 30-0011 43-0023 43-0024 33-0006 52-0015 40-0034 31-0015 45-0025 46-0038 38-0018 49-0003 38-0036 28-0016 52-0038 37-0025 33-0032 27-0014 48-0034 49-0033 34-0004 48-0026 44-0011 37-0039 28-0022 47-0008 36-0008 38-0008 42-0007 43-0004 31-0020 36-0020 31-0038 39-0030 38-0042 36-0033 34-0004 47-0004 37-0032 28-0024 47-0046 39-0027 46-0038 52-0007 45-0022 45-0016 35-0043 30-0029 40-0017 44-0022 44-0023 40-0011 46-0033 27-0016 30-0037 30-0042 49-0020 52-0008 38-0033 41-0027 27-0016 30-0036 46-0050 48-0009 30-0027 30-0025 37-0039 41-0032 39-0001 48-0025 35-0032 52-0021 46-0032 35-0039 39-0029 LAWRENCE, W.H. LAWSON, T.A. LEAL, Joseph R. LeBLANC, R. Bruce LEBOWITZ, Michael D. LEDERBERG, Joshua LEE, E.S. LEE, I. P. LEE, Ki P. LEE, K.W. LEE, Richard F. LEE, Young K. LEFEMINE, G. LEHMANN, Edward J. LEITIS, E. LEMEN, R.A. LEMKE, Armond E. LEMMER, Francis S. LEONG, B.K.J. LEPORINI, C. LEVIN, Simon A. LEVINSKAS, G.I. LEWIS, P.J. LEWIS, T.R. LIBBEY, L.M. LIEBERT, Charles LIENER, Irvin E. LIJINSKY, William LILLIAN, Daniel LILLIE, R.J. LILLY, Loma J. LINDLER, Bert LINZON, Samuel N. LIPPMANN, M. LISK, D.J. LISSNER, Reinhard LIU, Benjamin Y.H. LIU, Dai Kee LIWERANT, Irene Joab LLOYD, A.G. LLOYD, William J. LOB BAN, L. LODGE, J.P. LOHBARDO, Pasquale LONG, Janice R. LONG, Sue LOPRIENO, N. LORIMER, W.V. LOUTIT, M. LOVELOCK, J.E. LOW, Hans LU, Po-Yung LUCAS, James B. LUEB, R. LYMAN, Donald J. LYMAN, Frank L. LYNCH, R.P. LYNCH, Robert S. M & T CHEMICALS, INC. HABRY, L.C. MacBRIDE, Roland R. MACEK, Kenneth MACK, W.A. MADDOCK, B.C. MADDOCK, Jerome T. MAGEE, E.M. MAGEE, E.W. MAGEE, P.N. MAIENTHAL, E.J. MAKI, A.W. MALAVEILLE, C. MALICK, L. MALIK, M. MALLING, H.V. -34- ------- 48-0031 52-0005 39-0034 44-0028 30-0039 42-0012 31-0014 30-0047 29-0024 35-0046 48-0023 49-0028 32-0001 52-0008 51-0012 35-0003 35-0024 46-0020 52-0036 31-0031 38-0007 39-0001 52-0037 45-0005 48-0009 35-0007 49-0024 48-0038 32-0020 45-0029 49-0030 43-0033 38-0052 48-0010 43-0027 27-0033 28-0028 47-0019 45-0019 39-0004 33-0021 30-0029 40-0017 34-0003 31-0012 35-0006 51-0025 52-0039 31-0006 44-0007 52-0007 52-0008 37-0016 27-0003 41-0013 40-0035 47-0026 33-0001 33-0002 35-0042 50-0012 41-0016 28-0028 46-0027 35-0044 37-0038 28-0016 35-0041 41-0032 46-0047 47-0028 46-0009 37-0015 40-0012 45-0003 39-0025 35-0032 41-0024 41-0032 29-0012 37-0007 28-0027 32-0010 43-0036 MALTONI, C. MANGELSEN, N.F. MANMOHAN, D.O. MANOS, Nicholas E. MANTELL, G.J. MANZ, D. MARCHIO, J.L. MARMOT, Michael G. MARTELL, James M. MARTIN, J.H. MARTIN, J.M. MARTINO, Robert MASON, J.W. MATLAGE, W.T. MATLIN, S.A. MATSUMOTO, N. MATSUYAMA, Mutsushi MAY, T.W. McCAMMON, C.S. McCANN, Joyce McCLENDON, L.T. McCRAE, J. McCULLAGH, S.F. McGEEHAN, Thomas J. McGINLEY, Jorn R. McGOWAN, G.R. MCLAREN, Malcolm G. McMICHAEL, Anthony J McNEILL, I.C. McNUTT, Neil S. MEDEIROS, Edward J. MEDINA, Daniel MELLO, Nancy K. MELTON, R. MELVIN, Walter W. MENDOZA, C.E. MENIS, 0. MERESZ, Otto METCALF, Robert L. MEYN, M. Stephen MIELCZAREK, S.R. MIHAILOVICH, N. MILES, W.F. MILETTA, E.M. MILL, Theodore MILLER, A. MILLER, J.M. MILLER, Mathev F. MILLER, Walter T. MILLING, A. MILVY, Paul MINOURA, Yuji MIRVISH, Sidney S. MISRA, Hara P. MITCHELL, D. MITCHELL, J.R. MITCHELL, T.J. MITSUNO, Takao MOFFITT, A.E. MOHR, Ulrich MOKRONOSOVA, K.A. MOLINA, Mario J. MOLNAR, G. MONKMAN, J.L. MONTESANO, R. MOORE, Peter D. MORGAN, A. MORGAN, Karl Z. MORITA, M. MORROW, John 32-0002 43-0009 39-0034 52-0003 41-0022 32-0008 33-0030 42-0021 40-0015 41-0013 48-0015 45-0014 45-0039 52-0012 42-0028 33-0030 27-0039 47-0014 33-0025 37-0043 38-0001 35-0024 42-0014 31-0026 36-0018 46-0011 42-0026 30-0028 33-0022 33-0023 38-0022 43-0021 50-0001 46-0027 35-0044 30-0005 32-0011 42-0029 32-0009 30-0015 42-0011 33-0021 27-0005 52-0007 52-0010 41-0009 28-0007 46-0038 40-0025 43-0003 35-0023 37-0030 41-0013 35-0022 50-0019 32-0008 38-0037 31-0009 52-0004 41-0012 27-0036 30-0009 40-0005 33-0002 32-0010 43-0035 31-0036 41-0005 46-0046 48-0006 49-0007 41-0034 36-0005 31-0027 33-0024 45-0001 41-0029 35-0036 32-0029 40-0027 32-0028 40-0007 49-0016 52-0017 MORKOW, R.W. MORTON, Arthur R. MORTON, W. MOSELEY, B.E.B. MOSEMAN, Robert F. MOSLEM, Mary Treinen MOZDEN, P.J. MUELLER, W.F. MULLIN, L.S. MUMFORD, C.J. MUNGIKAR, A.M. MURIEL, W.J. MURPHY, Sheldon D. MURRAY, Chris MYERS, G.A. MYERS, Huston K.. MYERS, John L. NAGAYO, Takeo NAGEL, Donald NAIR, P.P. NATIONAL ECOLOGICAL RESEARCH LABORATORY, CORVALLIS, OREGON NATIONAL RESEARCH COUNCIL COMMITTEE BIOLOGICAL EFFECTS OF ATMOSPHERIC POLLUTION NAUMAN, C.H. NEELY, W.B. NEFF, G.S. NELSON, John D. , Jr. NELSON, K.V). NELSON, S.D. NETTESHEIM, P. NEUNER, Terry E. NEWBERNE, Paul M. NEWSOME, W.H. NIAZI, Sarfaraz NICHOLSON, A. Arnold NICHOLSON, W.J. NICOLOFF, H. NIEMI, Carol K. NIERI, R. NIOSH NISHIMURA, H. NISSIM, Jack E. NOHYNEK, G. NOMURA, T. NONEMAN, Jack W. NOONAN, Richard C. NORMAND, F.L. NORRIS, L.A. NORSTROM, Ake OBERDING, D.G. OBREMSKI, Robert J. O'BRIEN, R.C. OGAWA, Takeshi OISHI, S. OKADA, S. OLNEY, C.E. OLSON, R.J. O'NEILL, Leonard A. ONKEN, A. ORFHANIDES, Cue G. OSAWA, Zenjiro OS HA, U.S. DEPARTMENT OF LABOR OSTERMAN-GOLKAR, S. OSTERYOUNG, Janet OTT, M. Gerald OTTO, K. OTTONLENGHI, A.D. PALMER, Anthony K. PANGBURN, Michael K. PARASHER, C.D. -35- ------- 49-0008 44-0031 51-0009 43-0015 45-0022 48-0022 37-0010 37-0011 52-0012 32-0028 38-0020 52-0037 30-0016 38-0043 36-0023 52-0026 28-0016 51-0010 42-0024 46-0033 47-0023 47-0024 27-0012 33-0006 29-0006 38-0042 30-0005 30-0033 36-0019 44-0001 44-0010 48-0024 50-0001 48-0005 45-0023 38-0006 52-0016 32-0007 52-0003 33-0026 40-0011 49-0035 40-0005 33-0019 51-0011 47-0021 31-0037 45-0027 32-0034 41-0031 39-0002 44-0013 39-0023 27-0028 27-0032 43-0036 33-0039 30-0004 29-0016 30-0026 31-0014 31-0006 35-0019 41-0030 44-0037 46-0021 36-0002 29-0004 42-0005 31-0013 38-0005 40-0006 39-00 3A 35-0006 41-0012 48-0035 37-0013 37-0014 29-0017 39-0028 46-0023 36-0024 48-0038 31-0009 44-0034 44-0036 PARIENTE, R. PARIS, Doris F. PARKE, D.V. PARKES, D.G. PATRICK, F.M. PATTERSON, R.C. PAULET, G. PAWAR, S.S. PAYNE, W.W. PEARSON, J. Gareth PELLIZZARI, E.D. PENG, Geoffrey W. PENSABENE, J.W. PENTZ, William J. PENUMALLI, B.R. PERONE, V.B. PESRIN, J. PETERS, John M. PETERSEN, Robert V. PETERSON, D.B. PFENNINGER, K. PHELPS, Mary A. PHILLIPS, J.C. PICKET!, Edward E. PIEKACZ, Hanna PIELOU, B.C. PIERCE, F.D. PILTZ, F.M. PINTO, S.S. PIPER, Allan FITTER, P. PLANT, Albert F. PLIMMER, J.R. PLISS, Gennady B. POHL, D. POINESCU, I.C. POLLOCK, W. POLO, Joel PONTEFRACT, R.D. POPE, Martin POPE, W.D.B. PORCELLA, D.B. PORTER, John A.H. PORTNOY, B. POSNER, Herbert S. POUND, A.W. POWELL, John J. PRECISION VALVE CORP PRESCOTT, James H. PREUSSMAN, R. PRICKETT, Mary Sue PROCTOR, Nick H. PROKOFEVA, O.G. PURCHASE, I.F.H. PUTNAM, A. QUICK, Q. RADDING, Shirley B. RADWAN, Z. RAHAT, Ana RAHMAN, Mohammed T. RAHN, Kenneth A. RAJHANS, G.S. RALL, David P. RALOFF, Janet RAMAN ATHAN, V. RAMOS, Henry RANADIVE, V. RAO, K.V.N. RAPPE, Christoffer RASMUS SEN, R.A. RAWLS, Rebecca L. READ, John RECK, Ruth A. REEGEN, S.L. REES, David I. REEVES, W.A. REICH, Peter 33-0020 35-0019 44-0002 45-0014 48-0024 33-0030 42-0021 46-0047 47-0028 35-0041 40-0004 28-0020 42-0023 44-0004 29-0016 40-0007 46-0025 29-0024 42-0004 44-0030 43-0016 36-0007 33-0012 28-0003 30-0003 32-0011 41-0040 49-0040 35-0040 27-0005 52-0007 43-0019 46-0033 44-0007 37-0010 41-0030 28-0020 42-0023 45-0033 34-0014 46-0038 34-0003 33-0033 49-0036 52-0037 37-0015 40-0012 47-0030 41-0013 49-0019 37-0009 47-0006 46-0022 40-0010 39-0015 41-0033 52-0036 52-0015 30-0047 48-0019 41-0008 41-0010 47-0018 32-0035 42-0007 44-0037 45-0003 27-0002 38-0019 40-0017 32-0023 49-0031 46-0013 51-0008 32-0011 52-0037 45-0034 27-0031 52-0038 37-0032 42-0026 51-0014 40-0032 40-0009 48-0030 40-0009 46-0025 REICHERT, D. REICHLE, David E. REINHARDT, C.F. REISH, D.J. REYNOLDS, Edward S. REZNIK, Gerd REZNIK-SCHULLER, Hildegard RHYNE, Bonnie C. RICHARDS, R.J. RICHARDSON, C.R. RICHARDSON, Julian C. RICHTER, E. RICKERT, David A. RINDE, Esther RISBY, T.H. ROBBINS, A. ROBECK, Gordon C. ROBERTSON, D.F. ROBERTSON, Larry W. ROBOCK, Klaus RODGERS, Adrianne E. ROFFMAN, Amiram ROFFMAN, Haia K. ROGERS, Adrienne E. ROHL, A.N. ROLFE, Gary L. ROLL, David B. ROM, W. RONCIN, G. RONEN, A. ROSE, F.A. ROSE, V.E. ROSENKRANZ, Herbert S. ROSSI, Anna M. ROSSMAN, Toby ROUNBEHLER, David P. ROWLAND, F.S. ROWLAND, J. ROZMAN, K. RUBIN, I.E. RUBINO, Robert A. RUDERMAN, M.A. RUNDEL, R.D. RUSSELL, Clifford S. RYTTMAN, H. SAALWAECHTER, A.T. SACCOMANNO, G. SACKS, Susan T. SADANA, Ajit SAFE, S. SAFFIOTTI, Umberto ST. JOHN, L.E., Jr. SALAHUDDIN, A. F.M. SALMIVALLI, M. SAMUELS, Steven SANBORN, James R. SANDALLS, F.J. SANDERS, Virginia SANDORFY, C. SanGIOVANNI, M.L. SARA VIS, Calvin A. SAWICKI, E. SAYAD, R.S. SCALA, R. SCANLAN, R.A. SCHAFFNER, Robert M. SCHAIRER, L.A. SCHER, S. SCHERER, E. SCHIFF, H.I. SCHLATTER, Ch. SCHMELTEKOPF, A.L. SCHMID, A. -36- ------- 40-0033 38-0016 38-0036 33-0026 32-0035 43-0040 27-0016 37-0025 30-0020 35-0007 45-0025 43-0012 34-0004 29-0001 43-0034 51-0025 27-0038 36-0007 41-0029 35-0014 27-0005 44-0007 52-0007 52-0009 47-0030 41-0039 43-0034 51-0025 44-0030 30-0040 40-0028 52-0027 42-0008 42-0029 32-0016 38-0039 30-0027 28-0022 46-0030 50-0007 30-0006 33-0013 45-0019 49-0041 52-0021 43-0007 29-0024 30-0042 31-0031 48-0021 51-0010 29-0006 ' 29-0001 48-0035 46-0032 34-0004 47-0039 45-0002 30-0040 45-0034 36-0007 29-0005 36-0007 32-0001 48-0028 45-0012 52-0005 30-0022 40-0034 30-0026 39-0029 44-0005 41-0021 37-0045 52-0002 50-0012 42-0026 38-0028 33-0035 37-0016 37-0016 32-0020 44-0006 42-0013 47-0004 27-0034 SCHMID, E. SCHMIDT, Richard A. SCHNEIDER, F.H. SCHNEIDER, I. A. SCHNEIDERMAN, Marvin A. SCHROEDER, Henry A. SCHULZE, Jenos SCHWARTZ, Herbert SCHWEIKERT, Emile A. SCHWETZ, B.A. SCORER, R.S. SCOTT, Barry SEABRIGHT, Marina SEAMAN, Stephen SEARLE, A.G. SEEGER, Dennis R. SEGEBBACK, D. SEIDMAN, Irving SELIKOFF, I.J. SELLAKUMAR, A. SELTZER, Richard J. SEN, Nrislnha SERRAVALLO, F.A. SEVERS, L.W. SHABAD, L.M. SHAHANE, A.N. SHAIR, F.H. SHANK, R.C. SHANNON, Earl E. SHAPLEY, Deborah SHAW, H. SHEA, Kevin P. SHELDON, Richard C. SHERINS, R.J. SHERMAN, Henry SHIELDS, J.B. SHIH, Katherine Lu SHIMIZU, H. SHIREY, Steven B. SIEGEL, Frederic R. SIKKA, Harieh C. SIMMON, Vincent SIMONE, A. A. SIMPSON, B.R. SIMPSON, Harold N. SINCOCK, Andrew SINGER, G.M. SINGH, A.R. SINGH, H. Blr SINGH, M.M. SKIDMORE, J.W. SKORY, L.K. SLOCUM, Clots J. SLYSH, Roman SMITH, Bradford L. SMITH, P.M. SMITH, S.H. SMITH, T.J. SMITH, Wayne E. SMITH, Wesley E. SMITHSON, G. SNYDER, Sara SOLOMON, A. SOMERS, G. Fred SORENSEN, Alfred SORENSEN, E.M.B. SORNSON, H.C. SPARROW, A.H. SPEEK, A.J. SPENCE, John W. SPILLER, Lester L. SPIRTAS, Robert SPIVEY, Charles, Jr. SPRINGER, D.L. SPURNY, Kvetoelav SPYKER, Joan M. 28-0013 49-0023 52-0003 38-0011 40-0008 30-0013 31-0026 46-0026 47-0030 27-0016 37-0025 29-0008 37-0012 29-0010 49-0017 36-0007 45-0034 46-0054 37-0036 47-0004 30-0008 43-0004 40-0010 35-0015 52-0003 31-0031 49-0025 46-0038 52-0035 51-0010 27-0001 48-0041 38-0021 42-0027 37-0038 38-0049 41-0008 41-0010 50-0011 30-0038 43-0035 34-0007 41-0022 44-0015 46-0033 47-0024 36-0007 33-0030 42-0021 41-0007 37-0038 39-0020 42-0027 42-0027 48-0003 33-0005 33-0001 33-0002 47-0029 49-0014 29-0008 46-0050 45-0017 48-0035 37-0012 52-0036 29-0013 44-0024 35-0011 47-0008 27-0036 47-0040 38-0025 39-0025 28-0029 40-0009 33-0036 37-0011 38-0015 45-0003 34-0004 38-0031 44-0025 42-0014 52-0021 48-0014 SQUIRES, Arthur M. STAFFORD, John STARR, G. . STEDMAN, D.H. STEIN, Lawrence STEIN, N.S. STEINBACH, K. STENBACK, F. STBNSBY, Per S. STEPHENS, Edgar R. STERNAN, M.B. STEVENS, Alan A. STEVENSON, M.P. STEWART, Richard D. STICK, H.F. STOBER, Werner STOEWSAND, Gilbert S. STOLARSKI, P.S. STONARD, M.D. STOKER, J. STREITWIESER, David STRELOW, Roger STRETTI, G. STRINGER, W. STRUNIN, L. STUDEBAKER, M.L. STUKEL, James J. SUE, T.K. SUGIMURA, Takashi SUGIYAMA, Taketoshl SULLIVAN, L.J. SUNDSTROM, G. SUTHERLAND, M.E. SUZUKI, Norlo SWAFFIELD, Laura SWEET, Diana M. SWIFT, D.L. SWINYARD, Ewart A. SYMONS, James M. SZABO, Sandor SZWABOWSKA, M. TABUCHI, Yoshiki TAKADA, K. TAKAYASU, Hlsao TAKEUCHI, Tomio TAL, H. TALM1, Yalr TANINAKA, Takumi TANNENBAUM, Steven R. TASDIFF, Robert G. TAYLOR, Clifton 0. TAYLOR, D. TAYLOR, G.J. TAYLOR, H.W. TAYLOR, O.C. TEASS, A.W. TEFERTILLER, Nancy B. TELEGADAS, K. TEMPLE, Patrick J. TER HAAR, G.L. TERPOLILLI, Ralph N. THOBURN, Theodore THOMAS, R.S. THOMPSON, C.K. THOMPSON, T.L. THOMSON, A.J. THOS, A. TILLMAN, David A. TOIVANEN, A. TOOMEY, J. TORDELLA, J.P. TOSINE, Halle M. TOTH, Bela TOU, James C. -37- ------- 37-0010 37-0011 45-0014 34-0003 42-0004 40-0020 46-0038 46-0032 40-0029 40-0034 48-0027 42-0020 42-0027 27-0032 33-0035 27-0017 27-0018 27-0019 33-0020 40-0007 40-0030 38-0028 48-0025 39-0011 38-0025 40-0032 35-0014 52-0028 32-0020 44-0002 50-0008 40-0036 50-0030 43-0036 44-0021 39-0007 42-0022 31-0038 35-0006 45-0026 37-0010 44-0038 32-0009 33-0013 47-0002 52-0003 52-0006 45-0029 49-0030 52-0015 52-0035 48-0027 41-0011 42-0017 39-0012 48-0004 51-0010 48-0027 30-0006 52-0038 38-0029 49-0024 48-0027 44-0002 37-0016 45-0029 49-0030 52-0035 48-0023 47-0020 44-0005 38-0040 38-0012 31-0007 42-0024 41-0005 46-0046 48-0006 46-0048 •50-0013 44-0019 44-0020 50-0010 51-0014 TOULOUSE, P. TROCHIMOWICZ, H.J. TROLL, Walter TUCKER, Ralph G. TURCHI, G. TURNER, J.E. TYNDALL, R.L. TYO, Robert M. UDNOON, Sopsamom ULMACHNEIDER, Ronald W. UMEZAWA, Hamao UNGERER, 0. UPHAM, J.B. URBACH, F. URBAN, Th. URWIN, Colin VALLE, Ricardo T. VAN BATTUM, D. VANCE, B.D. VANDERSLIK, Allen L. VANDERVORT, Robert VAN DIJK, W.F.M. VAN DUUREN, Benjamin L. VAN ERT, Mark VAN HOOK, Robert I. VARSHAVSKAYA, S.P. VENITT, S. VERNICK, David VERNOT, E.H. VERSAR, Inc. VERVALIN, Charles H. VESELL, Elliot S. VESSELINOVITCH, S.D. VESTERBERG, 0. VIDAL, E. VIGLIANI, B.C. VILLENEUVE, D.C. WAGNER, J.C. WAGNER, S. WAGNER, W. WAGONER, J.K. WALKER, Anne E. WALKER, James C.G. WALLACE, Robert T. WALLIS, Ian G. WALSH, Paul R. WALTON, B. WARD, A. Mllford WARITZ, Richard. S. WARTHESEN, J.J. WATANABE, P.G. WATKINS, J. WATSON, Annetta P. WATTS, Donald M. WAXWEILER, R.J. WAYLAND, J.R. WEBER, K. WEBSTER, I. WEEKES, U.Y. WEEKS, Robert W. , Jr. WEETH, R.J. WEGMAN, David H. WEHNER, Alfred P. WEILL, Hans WEISBURGER, J.R. WEISS, William WESBROTH, S.H. 52-0003 45-0024 49-0003 45-0015 30-0038 47-0007 31-0001 31-0002 38-0028 38-0043 •48-0028 •30-0034 30-0029 35-0004 35-0045 44-0033 40-0019 39-0017 34-0014 27-0031 •44-0031 44-0036 43-0007 •51-0007 52-0036 47-0024 49-0031 48-0024 30-0037 35-0016 35-0024 38-0007 37-0021 48-0015 '38-0012 35-0023 52-0020 48-0039 31-0027 30-0030 40-0017 52-0019 37-0012 50-0016 32-0011 32-0033 36-0032 44-0031 44-0036 41-0033 30-0023 48-0036 46-0048 39-0002 44-0015 WESWIG, P. WETTSTROM, R. WHARTON, F.D., Jr. WHEATER, R.H. WHEELER, R.N. , Jr. WHITE, G.C. WILKINSON, B.K. WILLEMS, I. WILLIAMS, A.C. WILLIAMS, D.M.J. WILLIAMS, David T. WILLIAMS, John W. WILSHIRE, Frank W. WILSON, Hugh H. WIMER, W.E. WITHE Y, Jim R. WITZEL, Donald A. WLODKOWSKI, Theodore J, WOLCOTT, G. WOLFE, N. Lee WOLFF, Mary WOLFRUM, J. WOODFIN, W.J. WOODHEAD, J.H. WOODS, Shirley WORD, J.Q. WORK, G.A. WYROBEK, A.J. YAMADA, Seiji YAMASAKI, Edith YANG, Raymond S.H. YASUDA, Stanley K. YASUDA, Y. YIP, G. YOON, Soo-Choon YOSHITAKA, Ogiwara YU, Ching-Chieh YURAWECZ, M.P. ZAFONTE, L. ZAHRADNIK, Raymond L. ZAMCHECK, Norman ZAPP, J.A. , Jr. ZEPP, Richard G. ZETTERBERG, G. ZIMMERMAN, Martin B. ZINGMARK, P-A ZISKIND, Morton ZOOK, Elizabeth G. ZUSKIN, E. -38- ------- CATS Biweekly Reports Nos. 27 - 39 -39- ------- 27-0001 ACRYLONITRILE Beatty, J.R. and Studebaker,^M.L. THE RUBBER COMPOUND AND ITS COMPOSITION PART I: POLYMER, CURING SYSTEM, CARBON BLACK Rubber Age 107 (8): 20-35 (1975) This review describes price, processing, and properties as the major compounding factors; outlines 14 common processing problems; and discusses the functions of the various rubber compounding ingredients: elastomers, cure systems, fillers, processing aids, and other ingredients. Among the topics discussed are the selection of the polymer, the most important ingredient of a rubber compound; stress-strain values; abrasion resistance; permanent set; polymer blends; cure system; scorch control; fast cure systems; ease of dispersion; carbon blacks; and existing problems. In the selection of a curing system, care must be taken to avoid those chemicals which are toxic and may cause dermatitis. Some NBR rubbers with very good oil resistance have a high acrylonitrile content. Halogenated compounds, used as additives to reduce the flammability of polymers, seem to be most effective when used in conjunction with antimony oxide. -40- ------- 27-0002 ARSENIC Samuels, Steven and Howarth, Cynthia RESPIRATORY CANCER AND OCCUPATIONAL EXPOSURE TO ARSENICALS (Letter to Editor) Arch. Environ. Health 30_ (8): 423 (1975) Refuting the statement of Ott et al (See: CATS 7-0022) that a dose-response relation exists between an index of arsenic exposure and the ratio of observed- to-expected respiratory cancer deaths among Dow workers, the authors question the estimates of expected deaths; claim bias for the samples of exposed and control study groups; and raise the possibility that trivalent arsenic as well as pentavalent arsenic may have been present in the work environment, a factor that would hinder proper evaluation of the pentavalent form. -41- ------- 27-0003 ASBESTOS Dohner, V. Alton et al ASBESTOS EXPOSURE AND MULTIPLE PRIMARY TUMORS Am. Rev. Respir. Dis. _U2 (2): 181-99 (August 1975) Reviewing the case reports of 5 individuals with multiple primary tumors, the authors point out that most attending physicians did not know that these patients had been exposed to asbestos in their work and that the physicians were unaware of the potential health hazards associated with asbestos. The authors then review other reported instances of asbestos-related carci- nomas. They also tabulate the various uses of asbestos, listing a variety of industrial and domestic articles in which asbestos is used for heat insulation, electrical purposes, friction materials, and such miscellaneous uses as sheets, curtains, rugs, airplane wings, life jackets, etc. Occupational exposures include: asbestos rock mining, asbestos carding, asbestos cork insulation workers, pipe coverers, etc. Nonoccupational exposure includes residents near asbestos mills or near roads on which asbestos is trucked, those living in houses with asbestos insulation, etc. 27-0004 ASBESTOS Anon BENDIX CORP. ORDERED TO HALT ASBESTOS EMISSIONS: Environ. Health Lett. 14_ (16): 5 (15 August 1975) Because visible emissions of asbestos to the outside air were observed during a July 14 inspection of Bendix Corporation's Friction Materials Division, Green Island, N.Y., the company has been ordered by EPA to correct violations. No asbestos emissions are permitted under the national emissions standards for this chemical. Unless Bendix installs corrective air cleaning devices, it must stop its mixer dumping operations. -42- ------- 27-0005 ASBESTOS Rohl, A.N. et al EXPOSURE TO ASBESTOS IN THE USE OF CONSUMER SPACKLING, PATCHING, AND TAPING COMPOUNDS Science 189 (4502): 551-3 (15 August 1975) Spackling, patching and jointing compounds used for home repair work often contain asbestos fibers, according to researchers at the Environmental Science Lab., Mount Sinai School of Medicine, NYC. Although asbestos has been impli- cated as a carcinogen and OSHA has established safety levels for industrial exposure, there are no standards for the home workshop. Tests indicate concen- trations of asbestos in the home workshop higher than in factories. Warning labels for the adhesives are needed and it has been suggested that the use of potentially toxic or hazardous minerals in these products should be eliminated, 27-0006 ASBESTOS Anon EMISSION CONTROL AND ITS COST FOR THE TACONITE. . . J. Air Pollut. Control Assoc. 25_ (8): 796 (1975) EPA has commissioned an IGCI task group to determine the cost of emission control for the taconite ore processing industry. The group has already sur- veyed operations at Reserve Mining Company's ore mine at Babbitt, Minn., and at its concentrator plant at Silver Bay, Minn. (Asbestos in taconite tailings from Reserve Mining's operations has been the topic of water pollution/health hazard discussions recently). -43- ------- 27-0007 BENZIDINE Zimmerman, Stephen W. et al HYDROCARBON EXPOSURE AND CHRONIC GLOMERULONEPHRITIS Lancet 2^ (7927) : 199-201 (2 August 1975) Interviews of 63 adult patients with advanced renal failure showed that those with glomerulonephritis had been exposed more than others chronically to contact or inhaled toxicants, particularly hydrocarbon solvents. Several earlier reports have associated rapidly progressive glomerulonephri- tis with hydrocarbon solvent exposure, and one study indicated its induction in rats fed N,N'-diacetylbenzidine. -44- ------- 27-0008 FLAME RETARDANTS (New Products) Anon MORE NEW FR THERMOPLASTICS FOR MOLDING AND EXTRUSION Mod. Plast. _52 (8): 20 (1975) Diamond Shamrock Chemical Co. now offers Polytuf 200, a terpolymer of vinyl chloride, ethylene, and vinyl acetate as a flame retardant for molding and extrusion applications. -45- ------- 27-0009 FLUOROCARBONS Charlesworth, F.A. FLUOROCARBON PROPELLANTS IN PLAY AGAIN Food Cosmet. Toxlcol. 13. (3): 393-6 (June 1975) Following up an earlier review of the literature on fluorocarbons, which indicated that these materials were relatively safe, the author now reviews five papers that throw some doubt on earlier reports. In several, the development of cardiac arrhythmia in mice indicates that patients with bronchopulmonary disease run the risk of death by cardiac arrest from exposure to some fluorocarbons. Further studies with monkeys and dogs show similar findings including the fact that the fluorocarbons depress ventricular function in the canine heart. With humans, there is the possibility that excessive use of drug aerosols may induce cardiac arrhythmia and death. 27-0010 FLUOROCARBONS Anderson, Earl V. CARBON TET PRODUCERS FRET OVER THREAT TO FLUOROCARBONS Chem. Eng. News 53_ (33): 8-9 (18 August 1975) Another effect of the potential ban on chlorofluorocarbons is related to the production of carbon tetrachloride. In 1974, an estimated 92% of the 1.13 billion Ib. of carbon tet produced went into F-ll (trichlorofluoromethane) and F-12 (dichlorofluoromethane). Because more than 50% of these chlorofluoro- methanes are used in aerosols, the carbon tet producers could lose at least 50% of their major market. Some producers, who also have "swing" plants (those producing carbon tet as a coproduct with perchloroethylene) may convert much of their capacity to perchloroethylene. In 1975, carbon tet production may drop to under 900 million Ib. -46- ------- 27-0011 ISOCYANATES Anon MOBAY BOOSTS TDI TABS Chem. Wk. 117 (8): 23 (20 August 1975) Possibly starting a trend, Mobay Chemical will raise its bulk price of toluene diisocyanate (TDI) to 40e/lb in mid-September. Recently, TDI prices have been discounted to 35.7/lb. from the 45C list price set in August 1974. ISOCYANATES See also: 27-0021, Polyurethanes -47- ------- 27-0012 LIQUEFACTION AND GASIFICATION OF COAL Hall, E.H. et al FUELS TECHNOLOGY: A STATE-OF-THE-ART REVIEW Battelle Columbus Labs., Ohio. EPA/650/2-75-034. PB-242 535/3WK. (April 1975) The report gives results of a state-of-the-art review of various fuel-cleaning, fuel-conversion, and emission control technologies. It includes the following classes of technologies : physical and chemical coal cleaning, residual oil desulfurization, coal refining (liquefaction), coal and oil gasification, fluidized-bed combustion of coal, and stack gas cleaning. For each technology, the report presents the extent of current practice and the status of systems under development. [Abstract in: NTIS Weekly Govt. Abstracts, Chemistry, p. 313 (Aug. 18, 1975)] -48- ------- 27-0013 4,4'-METHYLENEBIS (2-CHLOROANILINE) (MOCA) Anon MORE MOCA RULES PROTESTED Mod. Plast. 52_ (8): 79-80 (1975) The Polyurethane Manufacturers Assn. (PMA) Is protesting OSHA's request for posting toxic chemical warning signs in areas where MOCA is used. PMA is also challenging the OSHA standards for MOCA that call for air-supplied hoods, showers, regulated areas for storage of sealed containers, and absolute. filters. -49- ------- 27-0014 NITRILOTRIACETIC ACID Greenblatt, M. and Lijinsky, W. CARCINOGENESIS AND CHRONIC TOXICITY OF NITRILOTRIACETIC ACID IN SWISS MICE J. Nat. Cancer Inst. 52.: 1123 (1974) Nitrilotriacetic acid (NTA), a chelating agent suggested as a partial replace- ment for sodium triphosphate in detergents, was previously tested as a carcino- gen in rats but the results were inconclusive. A later study with mice, given NTA and sodium nitrate in drinking water, indicates that NTA did not induce lung tumors in the 40 male mice tested but that 12% of the 40 female mice tested developed lung tumors. Incidence of lung tumors in controls was 19% in males and 12% in females. A combination of sodium nitrite and NTA in the drinking water gave a tumor incidence of 33% in males and 16% in females, a significant overall increase. [Review in: Food Cosmet. Toxicol. 13_ (3): 409-10 (June 1975)] 27-0015 NITRILOTRIACETIC ACID Anon NITRILOTRIACETIC ACID HAS BEEN CONFIRMED AS A CARCINOGEN. . . Chem. Eng. News 53_ (33) : 7 (18 August 1975) Long-term studies at the National Cancer Institute and the National Institute of Environmental Health Sciences confirm the carcinogenicity potential of NTA, which caused urinary tract cancers in rats and mice. NTA has again been suggested as a phosphate substitute for detergents; four years ago such use was stopped, when NTA was judged a potential teratogen. -50- ------- 27-0016 OPTICAL BRIGHTENERS Ganz, Charles R. et al ACCUMULATION AND ELIMINATION STUDIES OF FOUR DETERGENT FLUORESCENT WHITENING AGENTS IN BLUEGILL (LEPOM1S MACPOCHIRUS) Environ. Sci. Technol. 9_ (8): 738-44 (1975) Studies in which bluegills were exposed to four sulfonated stilbene fluorescent whitening agents (FWA's) indicate little tendency for the FWA's to accumulate in the fish tissue, which might later be consumed by man. Table shows acute toxicity of the four FWA's in bluegill,. in rainbow trout, and in Channel catfish. 27-0017 OPTICAL BRIGHTENERS Forbes, P.O. and Urbach, F. EXPERIMENTAL MODIFICATION OF PHOTOCARCINOGENESIS. I. FLUORESCENT WHITENING AGENTS AND SHORT-WAVE UVR Food Cosmet. Toxicol. 13_ (3) : 335-37 (June 1975) The increasing use of fluorescent whitening agents (FWAs) in numerous domestic products warrants studies of their potential environmental hazard. To determine if FWAs were photobiologically active or cocarcinogenic, hairless mutant (HRS/J) mice were exposed to germicidal, low-pressure mercury-vapor ultraviolet lamps, with and without pretreatment of the skin with the FWA, disodium 4,4'-bis- (4,6-dianilino-l,3,5-triazin-2-yl)-aminostilbene-2,2f- disulfonate, applied in 20 pg methanol. Mice were irradiated daily for several months. Those pretreated only with methanol before UV radiation developed erythema and skin cancers. Under the same conditions, mice pretreated with the FWA had a slightly longer latent period and developed fewer tumors. The FWA was considered to be non- phototoxic and non-cocarcinogenic. -51- ------- 27-0018 OPTICAL BRIGHTENERS Forbes, P.D. and Urbach, F. EXPERIMENTAL MODIFICATION OF PHOTOCARCINOGENESIS. II. FLUORESCENT WHITENING AGENTS AND SIMULATED SOLAR UVR Food Cosmet. Toxicol. 13_ (3): 339-42 (June 1975) Hairless mice, exposed daily for several months to UV radiation from a solar simulator, developed skin tumors (mostly squamous-cell carcinomas). Mice, whose skin was pretreated with the phototoxic agent 8-methoxypsoralen (0.01% in methanol), developed more tumors in a shorter exposure time. Mice pretreated with either sodium 2-(4-styryl-3-sulfophenyl)-2H-naphtho[l,2-d]- triazole or disodium 4,4'-bis-([4-anilino-6-(N-methyl-2-hydroxyethylamino)- l,3,5-triazin-2-yl]-amino) stilbene-2,2'-disulfonate, applied in methanol, showed no more severe response than those exposed only to UV irradiation. Thus, the two substituted-stilbene fluorescent whitening agents were judged not to be phototoxic or to enhance photocarcinogenesis. 27-0019 OPTICAL BRIGHTENERS Forbes, P.D. and Urbach, F. EXPERIMENTAL MODIFICATION OF PHOTOCARCINOGENESIS. III. SIMULATION OF EXPOSURE TO SUNLIGHT AND FLUORESCENT WHITENING AGENTS Food Cosmet. Toxicol. 13_ (3): 343-5 (June 1975) Hairless mice developed skin tumors, when exposed daily over a period of several months to UV, visible and infra-red radiation from a long-arc xenon- lamp simulating sunlight. Pretreatment of the skin with 8-methoxypsoralen (8-MOP) induced more tumors sooner, showing the 8-MOP to be a definite enhancer of photocarcinogenesis. Mice, whose skin was pretreated with any of four substituted-stilbene fluorescent whitening agents (FWAs), had fewer and less prevalent tumors than did the controls, indicating that the FWAs were not phototoxic and not cocarcinogenic. -52- ------- 27-0020 PERCHLOROETHYLENE Dowty, Betty J. et al NEW ORLEANS DRINKING WATER SOURCES TESTED BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY Environ. Sci. Technol. 9. (8): 762-5 (1975) A gas chromatograph-mass spectrometer-computer combination identified major aromatic and halogenated aliphatic compounds in New Orleans drinking water, in a commercial source of artesian water, and in deionized charcoal-filtered finished water. Tetrachloroethylene (perchloroethylene) and trichloroethylene were identified in two instances, but were not identified in the artesian water. PERCHLOROETHYLENE See: 27-0010, Fluorocarbons -53- ------- 27-0021 POLYURETHANES Gerrish, Sarah Lee URETHANE FOAM ON THE RISE Mod. Packag. 48 (8): 19-22 (1975) More packaging uses are anticipated for polyurethane (PU) foam, following changes in its chemistry and applications. An increasing market is seen for foam-in-place packaging, which now accounts for about 20% of total PTJ. Total urethane for packaging may climb to 25 million Ib. in 1975 compared to 18 million Ib. in 1974. From the safety standpoint, reduced toxicity is seen because of widespread switch from TDI (toluene-based) to MDI (methylene-based) chemistry. Also, one supplier reputedly has eliminated all Freon from his formulations, but has not identified the substitute. -54- ------- TRICHLOROETHYLENE See: 27-0020, Perchloroethylene -55- ------- 27-0022 SHALE OIL EXTRACTION AND REFINING Anon WILL SHALE YIELD CHEMICALS BEFORE OIL? Chem. Week 117 (8): 37 (20 August 1975) Colorado shale is now seen as a potential source of soda ash and sodium bicarbonate. The nahcolite-bearing oil shale could yield sodium bicarbonate at an operating cost of $10/ton and a capital cost of $4/ton, according to one estimator. Another sees a 1-million-ton/year nahcolite mining operation possible at a capital cost of $45 million and foresees a 300,000 to 500,000 tons-a-year market for calcined nahcolite. It may be that the shale will yield chemicals before it yields oil via the several in situ oil extraction processes now under consideration. One method, advanced by Shell, is a solution method in which superheated water is injected under pressure into the shale to dissolve the nahcolite, yielding a concen- trated solution of sodium bicarbonate, as well as crude oil. The system would disturb the landscape only slightly and would require very little water because of recycling. -56- ------- 27-0023 VINYL CHLORIDE Anon NATION'S NEWEST PVC PLANT IS A MODEL OF SAFETY, AUTOMATION, PRODUCT UNIFORMITY Mod. Plast. _52 (8): 14, 16 (1975) Georgia-Pacific's Plaquemine, La., 100,000 ton-capacity PVC plant, which came on stream in 1975, is in compliance with the 1 ppm time weighted average standards that OSHA plans to make effective next April for VCM. There are no walls, no roof, and no enclosures to trap vapors in the plant; its nine reactors are cleaned automatically, plant air is continuously monitored and an alarm sounds at any location where VCM level reaches 1 ppm. Output from the new plant will be sold on the market. 27-0024 VINYL CHLORIDE Anon OUTPUT OF MAJOR ORGANICS IN FIRST HALF WAS DOWN FROM YEAR-AGO TOTALS Chem. Week III (8): 13 (20 August 1975) The 342 million Ibs of VCM produced in June 1975 was 22% below June 1974 production, and the 1.67 billion Ibs produced in the first six months of 1975 was 40% under production during the first six months of 1974, reflecting the current downtrend for other major organic chemicals. Chemicals showing production drops from 23% to 37% for the month and from 26% to 46% for the first half of the year are butadiene, ethylene, propylene, styrene, acetic acid, and formaldehyde. -57- ------- 27-0025 VINYL CHLORIDE Anon DEMAND FOR CHEMICALS WILL REBOUND IN 1976 BUT NOT MATCH 1974 LEVEL Chem. Week 117 (8): 13 (20 August 1975) The 6% rebound in demand for nine major chemicals predicted for 1976 will not completely counteract the 7.5% drop in demand expected during 1975f according to Applied Econometrics, Melville, N.Y. A 41% drop in demand is predicted in 1975 for polyethylene, PVC, polystyrene, phthalic anhydride, and formaldehyde (all of which are used in plastics). In 1976, demand for these five materials should rise 30% but still fall about 21% below 1974 demand. Higher prices in 1976 are predicted for all 14 chemicals. 27-0026 VINYL CHLORIDE Anon FDA WILL PROPOSE TO BAN SOME USES OF POLYVINYL CHLORIDE IN FOOD PACKAGING. . . Chem. Eng. News 5.3 (33): 7 (18 August 1975) Fearful that vinyl chloride, a human carcinogen, from PVC bottles and wrapping paper, FDA may propose banning the use of PVC for some food packagings instead of merely limiting VC content of the PVC to 50 pbb. -58- ------- 27-0027 VINYL CHLORIDE Anon AT LONG LAST A PVC REG, MAYBE Mod. Packag. 48 (8): 53 (1975) Maybe, but again maybe not, is the prediction that FDA is about ready to set migration levels for vinyl chloride in food-contact packaging materials. Since early 1973, when FDA first learned of the migration problem, other government agencies, including the Coast Guard, have established VC regulations. FDA postponed its regulations in March 1975, pending study of Dr. Maltoni's findings that ingested VC may cause cancer in rats. The Society of the Plastics Industry, Inc. (SPI) claims that vinyl monomer is not migrating into foodstuff. SPI recently hired ex-EPA chief, W.D. Ruckelshaus, to help prod EPA into writing air-control standards for production of vinyl chloride. VINYL CHLORIDE See: 27-0008, Flame Retardants -59- ------- 27-0028 GENERAL INFORMATION Ivankovic, S. and Preussman, R. ABSENCE OF TOXIC AND CARCINOGENIC EFFECTS AFTER ADMINISTRATION OF HIGH DOSES OF CHROMIC OXIDE PIGMENT IN SUBACUTE AND LONG-TERM FEEDING EXPERIMENTS IN RATS Food Cosmet. Toxicol. 13 (3): 347-51 (June 1975) To test the toxicity and carcinogenicity of the pigment chromic oxide, BD rats were fed chromium oxide green (used as a cosmetics coloring) for 9.0 days (to test subacute toxicity) and over a two-year period (to test long-term toxicity and carcinogenicity). Although autopsy revealed reduced weights of liver and spleen in treated animals, no macroscopic or histological changes were noted. No toxic effects resulted from high oral doses over 90 days or two years and no carcinogenic action resulted, Although the oral route may be questioned for determining the effects of a cosmetic product, substances that are non-toxic given orally are usually non-toxic when applied to the skin. 27-0029 GENERAL INFORMATION Anon CHROMATES CITED AS CANCER LINK BY JAPAN Chem. Week 117 (8): 14 (20 August 1975) Sodium dichromate may have caused the deaths from lung cancer of 18 workers in Nippon Chemical Industrial (NCI) and Nippon Denko, according to Japan's Ministry of Labor. The 500,000 tons of waste that NCI dumped into Tokyo's Koto ward between 1939 and 1971 may be the cause of most of the chronic bronchitis and emphysema found in 583 of that area's residents. Chromates are also suspect carcinogens according to preliminary studies in Italy and Norway, and NIOSH in the U.S. may issue an alert on them. -60- ------- 27-0030 GENERAL INFORMATION Anon CHECKING ON CHROMATES Chem. Week 117 (7): 22 (13 August 1975) Having been informed by the Dry Color Manufacturers Assn. (DCMA) that the results of research in Italy and Norway, albeit inconclusive, suggest that chromates are carcinogenic, NIOSH will very shortly determine if it should issue an alert on these substances, which find extensive use in the pigment industry. Meanwhile, DCMA is sponsoring animal studies and epidemiologic surveys on chromates. In Italy, 26 of 40 rats injected with "chromate ores" developed tumors. The study, conducted by Cesare Maltoni of the Institute for Cancer Research in Bologna, may not be too relevant, however, because workers inhale chromates. In Norway, five cancers (3 of the lung and one each of the prostate, pancreas, and nasal passage) were discovered among 133 workers in a chromate pigment factory, where the workers were exposed to lead chromate, zinc chromate, and molybdenum chromate. 27-0031 GENERAL INFORMATION Burnett, C. et al LONG-TERM TOXICITY STUDIES ON OXIDATION HAIR DYES Food Cosmet. Toxicol. 13 (3): 353-7 (June 1975) Random-bred Swiss Webster mice were used to determine the potential skin toxicity of the major ingredients or reaction products in oxidation hair dye formulations. Over an 18-month period, groups of 100 mice received topical applications, weekly or biweekly, of three hair-dye formulations, which were mixed with hydrogen peroxide to provide actual use conditions. Chemical intermediates in these formulations included 2,5-toluenediamine sulfate, m-and p-phenylenediamine, resorcinol, 2,4-diaminoanisole sulfate, and 2,4-toluenediamine. The last compound, when given to rats in a sub- optimal diet (0.1% for 35 wks), induced liver cancers. In this study, however, no overt signs of systemic toxicity nor carcinogenic activity were noted from any of the formulations tested. -61- ------- 27-0032 GENERAL INFORMATION Eisenbrand, G. et al THE REACTION OF NITRITE WITH PESTICIDES. II. FORMATION, CHEMICAL PROPERTIES AND CARCINOGENIC ACTIVITY OF THE tf-NITROSO DERIVATIVE OF ^-METHYL-1-NAPHTHYL CARBAMATE (CARBARYL) Food Cosmet, Toxicol. 13 (3): 365-7 (June 1975) Because of the possibility that residues of certain pesticides or insecticides in food could react with nitrite in the stomach to form carcinogenic N-nitroso compounds, the capacity for nitrosation (under simulated stomach conditions) of carbaryl, the insecticide N-methyl-1-naphthyl carbamate, was measured. Addition- ally, the chemical and physicochemical properties of synthesized N-methyl-N- nitroso-1-naphthyl carbamate were studied and the carcinogenic action of this nitroso derivative were determined. Fourteen of 16 rats given a single sc dose of 1000 mg N-nitrosocarbaryl/mg developed local polymorphic-cell sarcomas at the injection site, but 21 months after receiving single oral doses of 200-15 mg/kg of the compound other test rats showed no evidence of tumors. 27-0033 GENERAL INFORMATION Mello, Nancy K. BEHAVIORAL TOXICOLOGY: A DEVELOPING DISCIPLINE Fed. Proc., Fed. Am. Soc. Exp. Biol. 34_ (9): 1832-4 (August 1975) Behavioral toxicology, an emerging development, should add new dimensions to the study of the effects of pollutants on man and help in the establishing of maximally acceptable concentrations of environmental and occupational pollutants. Although there are similarities between behavioral toxicology and behavioral pharmacology, there are major differences. Behavioral toxicological studies are aimed at detecting the effect of a toxic substance that may cumulate slowly over the years and not produce discernible behavioral effects until it reaches a critical concentration. It is urgent that techniques be developed to detect the early consequences of exposure to toxic chemicals. The long-term effects of asbestos exposure and the effects of poisoning by methylmercury and lead are cited as examples of the need for pre-determining the potential toxicity of chemicals. -62- ------- 27-0034 GENERAL INFORMATION Spyker, Joan M. ASSESSING THE IMPACT OF LOW LEVEL CHEMICALS ON DEVELOPMENT: BEHAVIORAL AND LATENT EFFECTS Fed. Proc., Fed. Am. Soc. Exp. Biol. 34_ (9): 1835-44 (August 1975) Behavioral toxicology and behavioral teratology are developing disciplines that may help define the potential effects on man of the many pollutants that are accumulating in the environment. Apparently, nervous tissue, particularly the brain, is affected by toxic chemicals with the adverse effects appearing as subtle behavioral disturbances quite some time before any toxic symptoms appear. Sensitivity is highest from conception to puberty. The developing brain is also sensitive to teratogens and their effects can also be evidenced in subtle behavioral abnormalities. These theories are illustrated by the results of studies with mice exposed to methylmercury during their prenatal and early postnatal period of development. 27-0035 GENERAL INFORMATION Leal, Joseph R. POLYBENZIMIDAZOLES Mod. Plast. 52_ (8): 60-2 (1975) Polybenzimidazoles are reviewed briefly as a class of polymers that are chemically stable and resistant to high temperatures, the all-aromatic polymers being thermally stable to about 500°C and those with aliphatic chains in the backbone being stable to about 350°C. A more detailed report is presented on the properties and prospective uses of poly-2,2'-(m-phenylene)-5,5'-bibenzimidazole, which is generally referred to as FBI. Produced from the condensation of 3,3',4,4'-tetra- aminobiphenyl and diphenyl isophthalate, PBI has been explored as a low-temperature adhesive, as a synthetic textile fiber with high moisture regain, and as a matrix tor reinforced composites and in laminates for ablative heat shields. Market viability is still more potential than actual, but the polymer has market potential, especially with the current emphasis on flame-proof materials. -63- ------- 27-0036 GENERAL INFORMATION Ter Haar, G.L. et al METHYLCYCLOPENTADIENYL MANGANESE TRICARBONYL AS AN ANTIKNOCK: COMPOSITION AND FATE OF MANGANESE EXHAUST PRODUCTS J. Air Pollut. Control Assoc. 25. (8): 858-60 (1975) The properties of the exhaust products resulting from the use of methyl cyclo- pentadienyl manganese tricarbonyl (MMT) as an antiknock agent in gasoline are described. It is concluded that no public health hazards will result from such use because of the very low concentration of MMT involved and because of the low toxicity of the manganese exhausted. 27-0037 GENERAL INFORMATION Anon PESTICIDE PLANT CLOSED Chem. Week 117. "(8) : 19 (20 August 1975) The finding of high toxic levels (2 to 25 ppm) of a chlorinated ketone in the blood of seven workers, who have been hospitalized (one with liver damage), has caused Life Sciences Products to close its Kepone pesticide plant in Hope- well, Va. Tests showed that about 30 other workers also had the pesticide in their blood, indicating higher levels present in the body's fatty tissue. Another 100 or so people, including former workers, will also be tested. Possible cause, according to plant officials, could be plant modifications made to meet water effluent standards. Life Science Products is the sole manufacturer of the Kepone, most of which is exported, with only about 0.8% of production used in this country to control ants and cockroaches. -64- ------- 27-0038 GENERAL INFORMATION Beechey, C.V. et al CYTOGENETIC EFFECTS OF PLUTONIUM-239 IN MALE MICE Nature 256 (5518): 577-8 (14 August 1975) Although potential genetic hazards from plutonium-239 have been considered less likely than carcinogenic hazards, a recent study indicated an effect on the testes of mice. Consequently, this reported study was undertaken to determine the induction of chromosome aberrations in male mice exposed to a particles from Pu-239. The results indicate that a radiation has the "expected high relative biological effectiveness" for causing chromosome damage. 27-0039 GENERAL INFORMATION Murray, Chris SCIENTISTS ISOLATE SOLID OXONIUM SALTS Chem. Eng. News 53_ (33): 20 (18 August 1975) Experiments conducted to develop new halogenated oxyfluorides via the hydrolysis of a halogen yielded instead some stable white solids, identified as oxonium salts. The new products, synthesized from antimony pentafluoride and hydrogen fluoride at low temperature, have unusual thermal stability. One possible use is the removal of traces of water from hydrogen fluoride gas streams, according to the Rocketdyne scientists who made the discovery. -65- ------- ARSENIC See also: 28-0018, Shale Oil Extraction and Refining -66- ------- 28-0001 ASBESTOS Anon PPG's CORPUS CHRISTI PLANT CITED FOR ASBESTOS EXPOSURE VIOLATIONS Chem. Week 117 (10): 10 (3 September 1975) OSHA claims that PPG's Corpus Christ!, Texas, chlorine plant has violated the asbestos standards. OSHA and the Oil Chemical & Atomic Workers Union are assessing amount of worker exposure at Corpus Christi. .The union claims conditions are similar to those at PPG's plant in Tyler, Texas, where an outbreak of asbestosis occurred. Apparently, 400 workers and former workers at the Tyler plant are believed to be subject to cancer as a result of their exposure to asbestos. 28-0002 ASBESTOS Harwood, Colin F. ASBESTOS EMISSIONS FROM BAGHOUSE CONTROLLED SOURCES Am. Ind. Hyg. Assoc., J. 36_ (8): 595-603 (1975) Although baghouses are the primary means of controlling emissions from asbestos processing plants, there seems to have been little work done on measuring baghouse efficiency in limiting asbestos fiber emissions. In this study, the mass efficiency of the baghouses of five processing plants, where chrysotile asbestos was used exclusively, was measured. In addition, fiber size was measured via optical and electron microscopy. Mass removal efficiency generally was higher than 99%, but the number of fibers greater than 1.5 pro in length was about 10^ fibers/m3. Apparently, enough fibers penetrate the baghouse fabric filter to warrant caution in recirculating the air. Should the baghouse fail, there might be a health hazard for workers. -67- ------- ASBESTOS See also: 28-0024, General Information -68- ------- 28-0003 BROMINATED BIPHENYLS Robertson, Larry W. and Chynoweth, David P. ANOTHER HALOGENATED HYDROCARBON Environment 17_ (6): 25-7 (September 1975) In this review of the previously reported toxic effects of polybrominated biphenyls (PBBs) accidentally fed to Michigan cattle, the authors cite several instances of the clear danger of ingested high levels of PBBs, but raise concern over the unknown effects on humans exposed to low levels over a long period of time. Studies are still underway to determine how people not directly exposed to the contaminated farm products can be exposed to the PBBs. According to one unpublished report autopsies showed detectable levels in fat samples of three such people. The various uses of PBBs and ways that they do or may enter the environment are discussed briefly. -69- ------- ETHYLENEIMINE See also: 28-0024, General information -70- ------- 28-0004 FLUOROCARBONS Anon CHLOROFLUOROCARBON BREAKDOWN ESTABLISHED Chem. Eng. News 53 (35): 15-6 (1 September 1975) NBS chemists, P.J. Ausloos and R.E. Rebbert, reported at the recent ACS meeting in Chicago that they have determined the photochemical mechanisms for the decomposition of chlorofluorocarbons in studies that Involved the use of four different wave lengths in the ultraviolet region of the spectrum. Apparently, up to two atoms of chlorine can be formed from each molecule of fluorocarbon 11 and fluorocarbon 12. Temperature, they report, may be important in the breakdown of the chloro- fluorocarbons in the stratosphere. In measuring the absorption cross section (using fluorocarbon 12), a 10-fold increase was noted as the temperature increased from 234 to 442°K. This indicates that chlorofluorocarbons may take longer to break down at the stratospheric temperatures than has been presupposed. 28-0005 FLUOROCARBONS Anon MCA WILL SPEND $5 MILLION TO STUDY THE EFFECTS OF CHLOROFLUOROCARBONS. . Chem. Eng. News 53_ (35): 7 (1 September 1975) The Manufacturing Chemists Association will provide the government with research results of its studies on the effects of chlorofluorocarbons on the upper atmosphere. Such studies will include detection of chlorine oxide, a decomposition product of the chlorofluorocarbons in the atmos- phere, using a microwave radar detection technique. -71- ------- 28-0006 FLUOROCARBONS Kay, A.N. OZONE LAYER (Letter to Editor) Chem. Eng. News .53 (34): 5 (25 August 1975) Commenting on a recent review of the chlorofluorocarbon controversy (See: CATS *19-0010), the author refutes the ozone destruction theory by suggesting that the action of sunlight on oxygen to form ozone will come into play. Any ozone destroyed will be formed again to yield no net change in the ozone concentration. Also, the suggestion is offered that reconstituted chloro- fluorocarbon, which is incombustible, will gravitate towards the sun and "put the sun out"...! 28-0007 FLUOROCARBONS Niemi, Carol K. LETTER TO EDITOR Aerosol Age 20_ (8): 6 (1975) Refuting a published statement that fluorocarbon propellants are used in oven cleaners, the author states that, although two new oven cleaners (one of which has been withdrawn) did contain fluorocarbons, nine others, accounting for about 94% of the market, do not. In the typical aqueous, alkaline formulation of these products the carbon- halogen bond of the fluorocarbons ruptures to yield high levels of chloride ions that work to corrode the interior of the aerosol container and permit the oven cleaner to leak out of the container. -72- ------- 28-0008 FLUOROCARBONS Anon GAINING A PERSPECTIVE Aerosol Age 2Qi (8) : 18-22 (1975) Reviewed here is the booklet, "Fluorocarbons", available from Kaiser Aluminum & Chemical Corp., Oakland, Calif., which reputedly presents a clear, compre- hensive review of the fluorocarbon/ozone controversy. In five segments, the booklet describes the reactions of ozone and the ultraviolet, the economic impact of fluorocarbons, the issue at hand (reviewing the various theories), the positions of scientists in government and industry, and the future. Kaiser (a major producer of fluorocarbons) reports that, if the theory should prove to be correct, halting fluorocarbon production now instead of in 1978 would cut any ozone depletion by only 0.5%. .Thus, the extra time to permit further research would not increase greatly any potential danger. 28-0009 FLUOROCARBONS Anon SPEAKERS UPDATE STATUS OF OZONE CONTROVERSY Aerosol Age 20 (8) : 30 (1975) At a May 28 seminar held by the Packaging Institute in Washington, Dr. Ralph Cicerone indicated that scientists are generally in agreement about the potential hazards of fluorocarbons in the stratosphere, and that there is enough proof to warrant government action. For industry, Robert Orfeo refuted Cicerone, citing various uncertainties in the ozone depletion theory and the need for more conclusive experimental evidence. Industry is supporting such studies as halocarbon detection, chlorine detection, and atmospheric chemistry studies at various universities, and is considering funding a study to develop stratospheric models with computers. -73- ------- 28-0010 FLUOROCARBONS Anon A SECOND STRATOSPHERIC RESEARCH BALLOON. . . Chem. Eng. News 53. (34): 26 (25 August 1975) The National Center for Atmospheric Research has launched and recovered its second balloon sent up to look for chlorofluorocarbons in the stratosphere; data are being analyzed. Data collected by cryogenic samplers in the first balloon showed chlorofluoro- carbons in the stratosphere that were evidently being broken down to chlorine atoms. 28-0011 FLUOROCARBONS Anon SCORER: OZONE THEORY IS 'UTTER NONSENSE' Aerosol Age 20 (8): 23, 43 (1975) The noted British Scientist, Dr. Richard S. Scorer, offers as his reasons for discounting the ozone theory: the inaccurate representation of the chemical reactions in the stratosphere via the computer model for the Rowland/Molina Theory; the fact that the ozone layer is not constant but varies from season to season, from day to night, and is ever being destroyed or created via natural processes; that the atmosphere receives much of its chlorine from volcanic eruptions, refuse burning, and other causes; that nature's checks and balances may help create more ozone; that potential health effects from decreased ozone are comparatively slight compared to other dangers to humans, etc. -74- ------- 28-0012 FLUOROCARBONS Anon FDA OPENS AEROSOL INQUIRY Soap, Cosmet. Chem. Spec. 51. (8): 22 (1975) Preparing for the possibility that fluorocarbons will be proved to be ozone depleters, FDA has ordered all manufacturers of drug products using fluoro- carbon propellents to submit detailed formulations, production amounts and other information to the agency. -75- ------- HALOETHERS See also: 28-0024, General Information -76- ------- 28-0013 LIQUEFACTION AND GASIFICATION OF COAL Squires, Arthur M. et al FLASH HYDROGENATION OF A BITUMINOUS COAL Science 189; 793-5 (5 September 1975) Based on previous work by the U.S. Bureau of Mines on rapid noncatalytic hydrogenation of various coals at short gas residence times, which provided a high liquid yield, Illinois coal was flash heated (to 700°C in 1 sec) in flowing hydrogen at 100 atmospheres. The process converted 7% of the carbon in the coal to methane, 7% to ethane, and 10% to benzene, toluene, and xylenes. 28-0014 LIQUEFACTION AND GASIFICATION OF COAL Klass, Donald L. SYNTHETIC CRUDE OIL FROM SHALE AND COAL Chemtech, pp. 499-510 (August 1975) A review of the different processes under development for the liquefaction of coal and oil shale and the problems involved in these processes. Because each ton of shale oil processed provides less than a barrel of oil, a huge solids disposal problem is faced. Spent shale lacks the necessary composi- tion that would make it a good fill for growing vegetation. The low hydrogen content of coal makes it less attractive than shale for commercialization, but there is less of a disposal problem associated with the liquefaction of coal. -77- ------- 28-0015 MODEL ECOSYSTEMS Gutierrez, Luis T. and Fey, Willard R. FEEDBACK DYNAMICS ANALYSIS OF SECONDARY SUCCESSIONAL TRANSIENTS IN ECOSYSTEMS Proc. Nat. Acad. Sci. U.S.A. 7J_(7): 2733-7 (1975) Based on Odum's tabular model of ecological succession, a theoretical dynamic model of the mutual causalities among abiotic and biotic matter and species diversity as they interact to produce secondary succession in ecological systems is proposed and validated. -78- ------- 28-0016 PHTHALATES Moffitt, A.E. et al ABSORPTION, DISTRIBUTION AND EXCRETION OF TEREPHTHALIC ACID AND DIMETHYL TEREPHTHALATE Am. Ind. Hyg. Assoc., J. 36^ (8): 633-41 (1975) A radiotracer study indicated that terephthalic acid and dimethyl tereph- thalate were rapidly absorbed and excreted by rabbits and rats to which the two compounds were administered orally and in other ways. There was no evidence of tissue retention of the compounds. Combined with earlier reports of low acute and chronic toxicity of these compounds, it appears that they do not represent a significant industrial health hazard. Workers should, however, avoid excessive or prolonged contact with either chemical. A table presents physical and chemical properties of the two compounds, which find a large use in the production of linear crystalline polyester resins. -79- ------- 28-0017 TRICHLOROETHYLENE Anon OCCUPATIONAL HEALTH ASPECTS OF TRICHLOROETHYLENE. . . Chem. Eng. News 53_ (34): 10 (25 August 1975) MCA has asked NCI to cooperate in long-term inhalation studies of trichloro- ethylene to aid in assessing its occupational health effects, Study is sponsored by six industrial firms. -80- ------- 28-0018 SHALE OIL EXTRACTION AND REFINING Anon PRETREATMENT PERMITS REFINING OF SHALE OIL Chem. Eng. News 53_ (35): 25 (1 September 1975) Metallic elements and other contaminants present in raw shale oil necessitate its pretreatment before refining. Coking and hydrotreating have been used to remove impurities. Although nitrogen can be removed by severe hydrotreating, arsenic must be removed before hydrotreating to prevent catalyst poisoning, Irradiation with ultraviolet light or treatment with metal oxides will remove the arsenic. Also, Arco now offers for licensing a process using caustic washes that reputedly reduces arsenic content from 40 ppm to 10 ppm. SHALE OIL EXTRACTION AND REFINING See: 28-0014, Liquefaction and Gasification of Coal -81- ------- 28-0019 VINYL CHLORIDE Greek, Bruce F. ETHYLENE BEGINS VIGOROUS RECOVERY Chem. Eng. News S3 (35) : 8-10 (1 September 1975) A 9% rise in ethylene production in June 1975 presages a continuing rise through the rest of the year, with estimates of more than 2 billion Ib. given for December 1975 production. Capacity expansions are planned for the next three years. One reason for optimism is the upsurge in derivatives production. Vinyl chloride production began to rise again in March with an upswing in the housing industry promoting the need for more polyvinyl chloride. 28-0020 VINYL CHLORIDE Richards, R.J. et al BIOLOGICAL REACTIVITY OF PVC DUST Nature 256; 664-5 (21 August 1975) Unlike silica and asbestos, the literature reveals a lack of detailed biological or biochemical information on PVC dust, either inhaled or ingested, and on its reactivity. In the tests reported here, PVC dusts showed a high hemolytic potential, which was reduced when a soluble, surface associated agent was washed off. Samples of PVC tested contained only immeasurable amounts of VCM. -82- ------- 28-0021 VINYL CHLORIDE Anon B.F. GOODRICH DEVELOPS CONTINUOUS STRIPPING PROCESS FOR PVC RESINS Chem. Week 117. (10): 39 (3 September 1975) B.F. Goodrich's new system for stripping vinyl chloride from PVC resins should be installed in all BFG plants by 1 Jan. 1976; it has been licensed to some other PVC manufacturers. Apparently, the method will yield PVC resins that will keep VCM emissions below anticipated EPA regulations. VINYL CHLORIDE See also: 28-0024, General Information -83- ------- 28-0022 GENERAL INFORMATION Shea, Kevin P. and Lindler, Bert PANDORA AND THE STORAGE TANK Environment 17_ (6): 12-5 (September 1975) In 1971 over 60 horses in central and eastern Missouri died from an unknown disease, which also hospitalized a child, made several people ill, and killed dozens of pet cats and dogs and hundreds of birds. Three years later the epidemic was traced to a tank of industrial waste residues containing the very toxic 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a by-product of certain industrial and agricultural chemicals. A year earlier, TCDD was identified as a contaminant of 2,4,5-T, a herbicide used in Vietnam. TCDD is easily absorbed through the skin. Animals exposed to it suffer liver and blood vessel damage, chloracne, gastric ulcers, and loss of appetite. In the ppb range it induces birth defects in animals. In humans, TCDD is excreted slowly and may accumulate in the body. TCDD has a half-life in soil of about one year. The Missouri epidemic occurred after "still residues" from the production of trichlorophenol in a Verona, Missouri, plant, which were hauled away by a waste collection company,were sprayed at a stable. Five days later, birds were found dead and two horses became ill. Six months later, newly exposed horses also became ill. Some horses died; others survived, but were later unable to breed. PCBs were detected in the soil but the child affected by the disease did not show elevated levels of PCBs. Later, 32 to 33 ppm of TCDD was detected in soil samples. Contaminated soil was removed and no further incidents were reported. The problem now is how to dispose of 4,300 gallons of still residues remaining in a tank at Verona. Another concern is the unregulated sale of PCB-containing wastes by the same waste collection agency. Although less toxic than TCDD, the PCBs are poisonous, manifesting symptoms similar to those caused by TCDD. 28-0023 GENERAL INFORMATION Anon THE NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH HAS AVAILABLE. . . Chem. Eng. News 53 (35): 7 (1 September 1975) The Dry Color Manufacturers Association last June advised NIOSH that chromate pigment production may be a potential cancer source. -84- ------- 28-0024 GENERAL INFORMATION Long, Janice R. OSHA PUSHES AHEAD ON HEALTH STANDARDS Chem. Eng. News 53_ (35): 12-3 (1 September 1975) In spite of a slow start — only 15 new health standards in 4.5 years — OSHA now seems to have surmounted various problems. First action on its planned program to update standards for 400 chemicals came with the recent publication of proposed standards for five ketones; before 30 Sept. OSHA plans to publish at least 10 proposed standards. The 15 new health standards established regulate worker exposure to 13 carcinogens, including bis-chloromethyl ether, ethyleneimine, asbestos, and vinyl chloride. Typical problems faced by OSHA are described briefly. 28-0025 GENERAL INFORMATION Anon HEW ASKS EPA TO CONSIDER VOIDING GE'S DISCHARGE PERMIT BECAUSE OF PCBs Environ. Health Lett. 14. (17): 1-2 (1 September 1975) HEW and the N.Y. State Environmental and Conservation Dept. have asked EPA to reconsider GE's permit to discharge PCBs in the Hudson River and Lake Champlain. According to an unpublished report, one grade of PCB at levels of 100 ppm may have caused malignant liver tumors in rats. Monkeys exposed to only 2.5 and 5 ppm have lost hair and weight, have developed acneform lesions and pregnancy problems. EPA is currently reviewing the carcinogenic potential of PCBs, has asked industry for test data on the chemical properties and potential bioactivity of PCB substitutes, and is conducting other studies. -85- ------- 28-0026 GENERAL INFORMATION Anon PESTICIDE PLANT FINED Chem. Week 117 (9): 14 (27 August 1975) After high levels of the pesticide, Kepone, were detected in the blood of workers, OSHA fined Life Science Products $16,500 for four violations of protective safety measures at its plant in Hopewell, Va. EPA and OSHA will inspect Allied Chemical's Union Texas Petroleum plant in Baltimore where Kepone is used in preparing formulations for export. EPA will also inspect Life Science Products' plant because wastes from the plant show concentrations of 500-600 ppb of Kepone; the established limit is only 100 ppb. 28-0027 GENERAL INFORMATION Morgan, Karl Z. SUGGESTED REDUCTION OF PERMISSIBLE EXPOSURE TO PLUTONIUM AND OTHER TRANSURANIUM ELEMENTS Am. Ind. Hyg. Assoc., J. 36_ (8): 567-75 (1975) Reviews the development of the current value of maximum permissible body burden of Pu-239 and discusses possible changes in the permissible exposure level. It is suggested that the linear hypothesis may not be conservative enough at low dose rates, especially for the actinide elements. More research needs to be done on the particle problem before setting a satisfactory maximum permissible body burden for Pu-239 based on the lung as the critical organ. A reduction of the current maximum body burden based on bone is suggested. -86- ------- 28-0028 GENERAL INFORMATION Deinzer, M. et al TRACE ORGANIC CONTAMINANTS IN DRINKING WATER; THEIR CONCENTRATION BY REVERSE OSMOSIS Water Res. £: 799-805 (1975) Before determining the potential health hazards of the many toxic organic chemicals that find their way into drinking water, it is necessary to determine accurately their concentration levels in the water. Reported here are the results of such studies using a reverse osmosis unit with a cellulose acetate membrane. Reverse osmosis can be used for measuring contaminant concentrations in large volumes of water and for detecting hydrocarbons, phthalates, chlorinated compounds, polyethers and other chemical classes. 28-0029 GENERAL INFORMATION Gillespie, D.M. et al A KINETIC MODEL FOR STATIC BIOASSAY OF INSECTICIDES Water Res. £: 817-9 (1975) Although static bioassays, used to evaluate the effects of toxins in aquatic environment, are not too reliable, a mathematical model is described that permits more accurate estimation of dosage from which toxicity indicators can be derived. The model was tested with DDT as toxin and stoneflies as assay organisms. -87- ------- 29-0001 ASBESTOS Sincock, Andrew and Seabright, Marina INDUCTION OF CHROMOSOME CHANGES IN CHINESE HAMSTER CELLS BY EXPOSURE TO ASBESTOS FIBRES Nature 257 (2251): 56-8 (4 September 1975) Cultured Chinese hamster cells were exposed for 48 hours and for 5 days at a concentration of 0.01 mg ml~l to four different dusts — chrysotile asbestos, crocidolite asbestos, glassfiber and glass powder. A table summarizing the results indicates that karyotypic alterations occurred primarily in those cells exposed to asbestos. Except for cells exposed for 5 days, to the chrysotile fibers, the longer exposure period did not significantly change the results of the 48 hour exposure. The multiple abnormalities produced at the chromatid and chromosomal levels of the test cells by asbestos fibers could lead to an in vitvo screening test for asbestos and other carcinogens. 29-0002 ASBESTOS Anon UNION BLAMES NAVY FOR CANCER OUTBREAK AMONG SHIPYARD WORKERS Chem. Week 117 (11): 14 (10 September 1975) The AFL-CIO claims that failure of the Navy to provide proper protective equipment for shipyard workers has led to an increased incidence of cancer among the workers. Some 500,000 individuals could develop various cancers from inhalation of solvents, paints, lead chromates, and asbestos. -88- ------- BROMINATED BIPHENYLS See: 29-0004, Benzidine -89- ------- 29-0003 BENZIDINE Anon BENZENE RINGS AND THE BLADDER Lancet .2 (7931) : 402 (30 August 1975) Britain's Dept. of Health has recently resumed its tracing of former rubber and cable workers whose exposure to g-naphthylamine makes them susceptible to bladder cancer. Mention is made of a short report by C.G.C. Caches [Proc. Roy. Soc. Med. 68; 525 (1975)], who discusses the effects on bladder of some aromatic compounds, citing two nonmalignant cases from exposure to y-benzene hexachloride (in a lindane fluid) and to pentachlorophenol. He points to the chemical structure similarity between phenyl phenol and naphthylamines, xenylamine, and benzidine, all known carcinogenic agent precursors. 29-0004 BENZIDINE Rail, David P. RESEARCHING HEALTH HAZARDS IN THE ENVIRONMENT J. Am. Water Works Assoc. 67_ (8): 447-8 (August 1975) The urgent need for studies on the potential hazards of industrial chemicals and the development of systematic toxicity tests are stressed. The U.S. currently manufactures some 10,000 chemicals to which between 500 and 1,000 new products are added yearly. Briefly reviewed are instances of past hazards — illnesses and deaths of animals in Michigan that were fed feedstock contaminated with brominated biphenyls; the VCM problem; the discovery that bischloromethyl ether, used in polymerization, is a potential bronchogenic carcinogen at 0.10 ppm; and the presence in river waters of haloethers, the byproducts of ethylene man- ufacture. The sudden peak to about 80 million Ib/year in 1970 of the PCB's and to about 1 billion Ib/year of phthalic acid esters recently demonstrates the difficulty in predicting production increases or new uses. -90- ------- 29-0005 FLAME RETARDANTS Slysh, Roman FLAME-RETARDANT COATINGS FOR PLASTICS J. Paint Technol. 47. (607): 31-6 (August 1975) Plastics made flame-resistant by the incorporation of flame-retardant additives have certain disadvantages, including the generation of smoke and toxic gases, which have been considered the cause of fatalities following fires. To counteract this effect, plastics were treated with an intumescent coating, a coating that bubbles and foams at high temperatures forming a multicellular insulating layer. Tests described in this paper indicate that such coatings at a thickness of 5 mils do reduce flame spread and smoke generation of plastics that melt above 170-180°C. Thicker coatings may work on plastics with melting points below 170°C. Formulas are given for typical latex-based and organic- based intumescent coatings, and reaction mechanism is discussed. 29-0006 FLAME RETARDANTS Simpson, Harold N. and Phelps, Mary A. HOW GLYCERINE, HAND LOTIONS AND BABY OIL AFFECT FIRE RETARDANT FABRICS Am. Dyest. Rep. 64. (8): 69-70 (1975) The use of three common household items — glycerine, hand lotions, and baby oil — can contaminate fire-retardant fabrics used for children's sleepwear, thus introducing a new hazard. The results of flammability tests are tabulated for cotton flannelette, nylon, and polyester fire retardant acetate tricot, after these materials had been contaminated with hand lotions and baby oil. -91- ------- 29-0007 FLUOROCARBONS Anon ATOMIC OXYGEN/AEROSOLS Environ. Rept. 6^ (9): 72 (8 September 1975) A 111-page report (NASA CR-2529) reviews chemical reactions possible in the stratosphere that may cause ozone depletion; discusses possible recombinations of atomic oxygen. Report is available at $5.25 fron NTIS, U.S. Dept. Commerce, Springfield, Va. 22161 or through NASA/contractor channels. 29-0008 FLUOROCARBONS Hester, Norman E. et al FLUOROCARBON AIR POLLUTANTS MEASUREMENTS IN LOWER STRATOSPHERE Environ. Sci. Technol. £ (9): 875-6 (1975) Air samples collected in lower stratosphere (21,000, 40,000, and 60,000 ft) indicate that measured concentrations of fluorocarbon 11 and fluorocarbon 12 agree, in general, with the concentrations predicted by the Cicerone model. When compared with 1973 data, the new measurements reflect a trend toward increasing concentration levels, as anticipated from increased fluorocarbon production and release. -92- ------- 29-0009 FLUOROCARBONS Anon FLUOROCARBONS' ROLE IN OZONE DEPLETION THEORY RECEIVES ADDITIONAL DEBATE J. Air Pollut. Control Assoc. 25. (9), 961 (1975) Dr. R.L. McCarthy, director of Du Font's "Freon" Products Laboratory, questions the reported confirmation of ozone depletion in the stratosphere from fluoro- carbons, based on measurements of fluorocarbons in the stratosphere announced by the National Center for Atmospheric Research, Boulder, Colo. McCarthy does not deny the presence of stratospheric fluorocarbons, but argues for studies to determine if the chlorine/ozone chain reactions in the strato- sphere are similar to or different from those conducted in lab experiments. -93- ------- HALOETHERS See: 29-0004, Benzidine -94- ------- 29-0010 HYDRAZINE Fairchild, M.D. and Sterman, M.B. UNILATERAL SENSORY-MOTOR-RHYTHM (SMR) TRAINING IN CATS: A BASIS FOR TESTING NEUROPHYSIOLOGICAL AND BEHAVIORAL EFFECTS OF MONOMETHYLHYDRAZINE (MMH) California Univ. Los Angeles School of Medicine, Final rep., 1 April 1972- 31 March 1973, Contract F33615-72-C-1855. Rep. AMRL-TR-73-123 (July 1974). (AD-A011 578/2GA). Cats were trained to produce sensory-motor-rhythm (SMR) in one brain hemisphere and to suppress it in the contralateral hemisphere. Rewarding brain stimulation was delivered automatically to the lateral hypothalamus when trains of SMR of specified duration and amplitude appeared only in the trained hemisphere. Evoked potentials induced bilaterally in the sensory-motor cortex by stimulation of radiations from the nucleus ventralis posteriolateralis of the thalamus were photographed and measured prior to, during, and following training. Unilateral SMR production could be achieved, but this training procedure had no systematic effect on thalamocortical evoked potentials; although changes unique to each of the three animals tested occurred more frequently in the trained hemisphere. [Abstr. in: Government Reports Announcements 7^5 (17): 51(22 August 1975)] 29-0011 HYDRAZINE George, Marilyn E. EFFECTS OF MONOMETHYLHYDRAZINE ON RED BLOOD CELL METABOLISM Aerospace Medical Research Laboratory Wright-Patterson AFB Ohio, Tech. Rep. AMRL-TR-74-87 (March 1975). (AD-A011 548/5GA) Monomethylhydrazine is used in various Air Force propellant systems. Chronic exposure to low concentrations of this compound results in an anemia characterized by methemoglobinemia, decreased levels of reduced glutathione and Heinz body formation. The study reported here was designed to determine if Heinz body formation was the principal mechanism of the red cell destruction or if MMH also had effects on the glycolytic pathways and/or red cell membranes which would contribute to the hemolytic mechanism. Human red cells were exposed in vitro to three levels of MMH for two, four, or six hours. Glucose utilization, lactate production and ATP levels were measured to determine effects on glucose metabol- ism; and osmotic fragilities, red cell potassium concentration, and malonyl- dialdehyde levels were measured to assess membrane effects. [Abstr. in: Government Reports Announcements 75 (17): 50 (22 August 1975)] -95- ------- 29-00.12 MODEL ECOSYSTEMS Moore, Peter D. CARBON DIOXIDE FLUX IN ARCTIC ECOSYSTEMS Nature 257 (5522): 90 (U September 1975) Recent studies of carbon dioxide flux between soil, vegetation, and the atmos- phere have shed additional light on the arctic terrestial biome. Additionally the studies indicate the potential usefulness of carbon dioxide flux as a means of approaching gross ecosystem energetics. -96- ------- NAPHTHYLAMINES See: 29-0003, Benzidine -97- ------- 29-0013 PERCHLOROETHYLENE Billing, Wendell, L. et al EVAPORATION RATES AND REACTIVITIES OF METHYLENE CHLORIDE, CHLOROFORM, 1,1,1-TRICHLOROETHANE, TRICHLOROETHYLENE, TETRACHLOROETHYLENE, AND OTHER CHLORINATED COMPOUNDS IN DILUTE AQUEOUS SOLUTIONS Environ. Sci. Technol. £ (9): 833-8 (1975) To determine the potential persistence of various chlorinated compounds in water, the authors studied the title compounds for their rate of evaporation, adsorption on soils, and the chemical reactions of hydrolysis and oxidation. They also determined the evaporation rates from water of 22 other chlorinated compounds. All compounds were tested at the level of 1 ppm in water under ambient conditions. The title compounds evaporated rapidly from slowly stirred water in the presence of natural or added contaminants, evaporating to 50% in less than 30 min. and to 90% in less than 90 min. Slower evaporation of the other 22 compounds indicates that, in general, a higher molecular weight slows the evaporation process. Therefore, at 1-ppm levels, low-molecular weight chlorinated compounds should not persist in natural waters.. Hydrolytic- oxidation reaction half-lives for the title compounds were ^6-18 months. -98- ------- PHTHALATES See: 29-0004, Benzidine -99- ------- 29-0014 POLYURETHANES Anon POLYURETHANES HAVE RESISTED THE RECESSION. . . Chem. Eng. News 53 (37): 10 (15 September 1975) Although flexible polyurethane foams showed a demand drop of 8-10%, in the first six months of 1975, rigid foams showed a slight rise in demand, according to a report from Peter Sherwood Associates, NYC. Demand for poly- urethanes should accelerate to end of the 1970's. Annual growth rates predicted for 1974-1980: flexibles, 11.8%; rigids, 15.6%; and noncellular elastomers, 22.5%. -100- ------- 29-0015 VINYL CHLORIDE Anon ADDING TO VCM FUROR Chem. Week 117 (11): 16 (10 September 1975) With 60 days from 3 Sept. 1975 to respond to FDA's proposed regulation banning use of semirigid and rigid PVC in food-contact packagings, manufacturers are optimistic about proving lack of migration of VCM from PVC bottles and sheets. Goodrich Chemical, for one, has announced a new stripping technique for making PVC resins with less than 1 ppm VCM. On the other hand, the Health Research Group believes industry will not succeed in changing FDA's position because under the Delaney amendment food packaging materials should contain no VCM. Current detection methods permit detection of 0.1 ppb. 29-0016 VINYL CHLORIDE Purchase, I.F.H. et al CHROMOSOMAL AND DOMINANT LETHAL EFFECTS OF VINYL CHLORIDE Lancet 2. (7931): 410-1 (30 August 1975) To determine the potential mutagenicity of VCM in men and animals, studies were made of 86 workers, 56 of whom had been exposed to VCM. Lymphocyte cultures showed a. significant increased (P<;0.05) percentage of B, Cu, and Cs cells in the exposed workers, confirming earlier reports that VC causes chromosomal aberrations in humans. However, in a dominant lethal study using mice, the results indicated that even at levels of 30,000 ppm VCM does not produce dominant lethal mutations. Apparently, the active metabolites of vinyl chloride do not reach the testis. -101- ------- 29-0017 VINYL CHLORIDE Rawls, Rebecca L. PVC MAKERS CONFIDENT ON FOOD-CONTACT USES Chem. Eng. News 5J3 (37): 11-12 (15 September 1975) Even If FDA bans the use of PVC food bottles and PVC blister packages for foods, the ruling will affect less than 1% of total U.S. capacity for PVC. Currently, about 50 million Ibs of PVC goes into such products. Other permitted food related uses consume about 250 million Ib/year of PVC and PVC water pipes use over 400 million Ibs/year. 29-0018 VINYL CHLORIDE Anon STUDY INDICATES POSSIBLE LINK BETWEEN VINYL CHLORIDE AND HEART DISEASE Chem. Week 1.17 (12): 36 (17 September 1975) Preliminary studies indicate that vinyl chloride may cause heart and cardio- vascular diseases. The 28 heart-related deaths found in a study of 771 workers at the KemaNord plant in Stockvik, Sweden, is considered excessive; 18 such deaths might have been anticipated. Additional studies are planned, however. Although the reported study covered the years 1944 to 1973, it involved workers employed for less than 3 years, was conducted in an area with a normally high rate of heart deaths, and include some Finnish workers. -102- ------- 29-0019 VINYL CHLORIDE Kappus, H. et al RAT LIVER MICROSOMES CATALYSE COVALENT BINDING OF ^C-VINYL CHLORIDE TO MACROMOLECULES Nature 257 (5522) : 134-5 (11 September 1975) This study with rat liver microsomes confirms earlier studies in bacterial test systems that vinyl chloride (and also vinylidene chloride) are mutagenic, but only so in the presence of rat liver microsomes that form the mutagenic metabolite. Tabulated data shows the need for NADPH-regenerating system in the covalent binding of VC metabolites to rat liver microsomes, and shows that VC metabolites can be bound to albumin and to RNA. VINYL CHLORIDE See: 29-0004, Benzidine -103- ------- VINYLIDENE CHLORIDE See: 29-0019, Vinyl Chloride -104- ------- 29-0020 GENERAL INFORMATION Anon TRACE KEPONE TO KIN Chem. WeekJLl? (11): 18 (10 September 1975) Ten relatives of 12 workers at Life Science Products plant in Hopewell, Va., were found to have from 0.1-0.8 ppm of the pesticide, Kepone, in their blood. A 2 ppm level is considered acute. Workers may have carried Kepone dust on their clothing. Lab studies of tests of 119 of 149 former and present employees continue. Kepone handlers at Allied Chemical's Hopewell plant will be tested and plans now include testing of some 200 Hopewell households to determine potential community exposure. 29-0021 GENERAL INFORMATION Anon PCB HAZARD Environ. Rep. 6. (9): 65-6 (8 September 1975) Detection of excessively high levels of PCB's in Lake Michigan fish, as well as in fish in the Hudson River, adds impetus to the growing concern among EPA officials and others for the need of a drinking water standard for PCB's. -105- ------- 29-0022 GENERAL INFORMATION Anon PCP IN HUMANS Environ. Rep. 6. (9): 66 (8 September 1975) Low amounts of pentachlorophenol (PCP) have been found in the urine of students at Florida State University, Tallahassee. In addition, up to 70 ppb of PCP were found in seminal fluid. The latter portends potential birth defects and genital cancers, since PCP, which is found in various herbicides, has caused mutations in lab experiments. Residues of PCP averaging 10 ppm have been found in food and paper products found in Tallahassee supermarkets. 29-0023 GENERAL INFORMATION Anon PESTICIDE CITED AS POSSIBLE CARCINOGEN Environ. Rep. 6. (9): 67 (8 September 1975) EPA researchers warn that Atrazine, a widely-used pesticide, could be changed into a cancer-causing chemical in the human stomach. Atrazine reacts with nitrite yielding N-nitrosatrazine, a potential carcinogen. Basis for concern: Atrazine has been detected in Iowa and Illinois drinking water supplies. Some meat preservatives contain nitrite compounds. -106- ------- 29-0024 GENERAL INFORMATION Martell, James M. et al PCB's IN SUBURBAN WATERSHED, RESTON, Va. Environ. Sci. Technol. £ (9): 872-6 (1975) Detection of PCB's in Lake Anne, Reston, Va., confirms the theory the PCB's tend to spread and persist in water. Because Reston has no industrial or sewage discharge, the PCB's evidently resulted from various sources connected with the construction of waterfront property. Tabulated data indicate about a 500-fold increase in PCB concentration from water to bed sediment, and a 3000-fold increase from water to fish. 29-0025 GENERAL INFORMATION Anon THE SENATE HAS VOTED TO BAN FEEDING OF DIETHYLSTILBESTROL TO ANIMALS. . . Chem. Eng. News 53_ (37): 10 (15'September 1975) Diethylstilbestrol (DES), a growth stimulant, has caused cancer in small test animals. Thus, Senate bill S. 963 prohibits its being given to animals that will be used as food, unless HEW determines that DES is safe for humans. Also, use of DES as a morning-after contraceptive has been limited to medical emergency cases, and the label must carry a potential cancer warning. Bill S.963 must pass the House, however, before becoming a law. -107- ------- 29-0026 GENERAL INFORMATION Anon LETHAL GASES HELD RESPONSIBLE FOR DEATHS OF 12 NON-COAL MINERS IN RECENT MONTHS Occup. Health Saf. Lett. 5. (16): 7 (22 August 1975) The deaths of 12 non-coal miners in recent months has prompted the Mining Enforcement and Safety Administration (MESA) to order mine safety personnel to increase precautionary measures and to publicize the hazards of toxic and explosive gases found or used in mining operations. 29-0027 GENERAL INFORMATION Anon NIOSH REPORT BRINGS TOGETHER STUDIES ON MORTALITY PATTERNS IN STEEL INDUSTRY Occup. Health Saf. Lett. 5. (16): 7-8 (22 August 1975) A recent NIOSH report, "Comparative Cause-Specific Mortality Patterns by Work Area Within the Steel INdustry," reports on the analysisfof mortality patterns in more than 58,000 Alleghany County, Pa., steel workers in 1953. An excessive death rate from lung cancer was noted among coke oven workers, but 26 other causes of death are tabulated. Factors other than the work environment may have contributed to the mortality differences reported. -108- ------- 30-0001 ASBESTOS Codding, C.N. and Cross, Frank L., Jr. ASBESTOS Pollut. Eng. I (9): 103 (1975) Brief summary to provide answers to specific control problems touches upon typical sources of asbestos, its contamination effects, allowable concen- trations, testing methods for the work environment, and control methods and equipment. 30-0002 ASBESTOS Haley, Thomas J. ASBESTOSIS: A REASSESSMENT OF THE OVERALL PROBLEM J. Pharm. Sci. 64 (9): 1435-49 (1975) With world production of four types of asbestos (amosite, anthophyllite, chrysotile, and crocidolite) at 3 million tons/year and with the increasing exposure of humans to asbestos fibers in air and in drinking water, this reassessment of asbestosis is timely. The review is based on the litera- ture published primarily from 1961 through 1974 (includes one 1946 and one 1958 reference), and covers the following topics: sources and uses, analytical chemistry, biochemical aspects, industrial hygiene aspects, animal toxicology and carcinogenesis and human toxicology and carcinogenesis from various sources of exposure. It is concluded that greater attention should be given to analytical chemistry, particle size, and epidemiology, and that studies should be made on the effects resulting from the ingestion of various forms of asbestos fibers. -109- ------- 30-0003 ASBESTOS Klosterkotter, Werner and Robock, Klaus NEW ASPECTS ON DUST AND PNEUMOCONIOSIS RESEARCH Am. Ind. Hyg. Assoc., J. 36. (9): 659-68 (1975) Pneumoconiosis occurs in miners and other workers exposed to the dusts resulting from the processing and treatment of raw materials. The effects of silica dioxide, coal dust, and asbestos and the mechanisms involved in their effects on lungs are discussed. It is suggested that electron transfer reactions may be harmful mechanism for silica dioxide. Although asbestos can also be considered a semiconductor in the physical sense, its different electron structure and other factors seem to indicate that the specific pathogenicity of asbestos dust is due primarily to specific properties of the fibers them- selves. -110- ------- 30-0004 BENZIDINE Prokofeva, O.G. INDUCTION OF HEPATIC TUMORS IN MICE BY BENZIDINE EPA-TR-118-74, Translation of Voprosy Onkologii (USSR) 17 (5): 61-4 (1971) Studies were performed on mice of the C3HA line which were sensitive to hepatotropic cancerogens. According to reports of several authors, the spontaneous development of hepatomas was observed in 1% at the most of C3HA mice. A comparison of the present studies with the indices of tumors developing spontaneously in mice of the C3HA line reveals the clearly expressed hepatotropic action of benzidine. [Abstr. in: Government Reports Announcements .74. (4) : 27-8 (21 February 1975) ] -111- ------- 30-0005 BORON Neuner, Terry E. et al SPECTROPHOTOMETRIC DETERMINATION OF BORON IN BORONATED FERTILIZERS J. Assoc. Off. Anal. Chem. 58. (5): 920-2 (1975) This modification of the Picket et al method [J. Assoc. Off. Anal. Chem. 54: 796-800 (1971)] to analyze acid-soluble boron in fertilizers is shown to be inexpensive, convenient, and accurate for detection limits of 1 ppm. For the measurements described the Perkin-Elmer Model 403 atomic absorption instrument was used but any instrument with suitable capabilities can be used since the emission maximum is broad (half-intensity ca 8 nm). -112- ------- 30-0006 BROMINATED BIPHENYLS Lee, Ki P. et al OCTABROMOBIPHENYL-INDUCED ULTRASTRUCTURAL CHANGES IN RAT LIVER Arch. Environ. Health 30 (9): 465-71 (1975) The flame retardant composed of hepta-, octa-, nona-, and decabromobiphenyls (OBB), although an effective agent for flame resisting synthetic fibers, was dropped by Du Pont, when it was found to cause liver damage in rats fed the compound at 100 and 1000 ppm. The ultrastructure and morphogenesis of the resulting hepatocellular changes were studied via light microscopy and electron microscopy and the results are described here. -113- ------- 30-0007 BROMINATED BIPHENYLS Fehringer, Norbert V. DETERMINATION OF POLYBROMINATED BIPHENYL RESIDUES IN DAIRY PRODUCTS J. Assoc. Off. Anal. Chem. 58. (5): 978-82 (1975) The accidental deaths of dairy herds given feed contaminated with PBBs emphasizes the need for detecting PBBs in dairy products. Described are several gas-liquid chromatographic (GLC) analyses that serve that purpose, plus a gel permeation chromatographic (GPC) cleanup procedure, and a thin layer chromatographic (TLC) confirmation procedure. -114- ------- 30-0008' BROMINATED BIPHENYLS Babish, John G. et al POLYBROMINATED BIPHENYLS: TISSUE DISTRIBUTION AND EFFECT ON HEPATIC MICRO- SOMAL ENZYMES IN JAPANESE QUAIL J. Agric. Food Chem. 13 (5): 879-82 (September/October 1975) Japanese quail ate a semi-purified soybean protein-cornstarch diet containing from 0 to 100 ppm polybrominated biphenyl (PBB) but would not eat the food containing 1000 ppm. In tests conducted over a 9-week period, the PBB diet did not cause loss of appetite or retard growth. Egg production was not affected by diets containing 10 or 20 ppm PBB, but at 100 ppm egg production was reduced to 17% versus 68% in the controls and no eggs were hatched. Four liver microsomal enzymes were induced by the PBB diets, but no post-mortem gross or microscopic lesions were observed. Quail fed diets containing 500 ppm PBB died within a few days. -115- ------- 30-0009 DIOXANE Obremski, Robert J. DIOXANE Pollut. Eng. 7_ (9): 22 (1975) Used as a solvent in lacquers, paints, dyes, and in some plastic and chemical manufacturing plants, 1,4-dioxane is a toxic chemical which should be kept out of the plant atmosphere. Dangerous both from acute and repeated exposures, inhalation of dioxane can cause intoxication and death. One death was reported from exposure over several days to 470 ppm of the compound, which produced bronchopneumonia, and damaged the CNS, the liver and the kidney, leading to the death. The ACGIH 8-hr weighted average threshold limit value for.dioxane is 50 ppm. Dioxane is also flammable and may explode in concentrations of 2 to 22%/volume of air. Infrared spectrophotometry, mass spectrophotometry and gas chromatography can be used to detect its presence. -116- ------- 30-0010 FLAME RETARDANTS Anon FOR CHEMICALS AND ADDITIVES A NEW SPLASH IN R & D Mod. Plast. 52_ (9): 41-58 (1975) Despite declining use of chemicals and additives in 1975, R & D developments are prolific. This review covers market performance and new products in the fields of additive lubricants, antioxidants, flame retardants, plasticizers, UV stabilizers, etc. For flame retardants, a slow 1975, due in part to large inventories, should give way to an improving market in 1976 and later. Plastic TV cabinets use 3000 to 4000 tons of FR chemicals, but intumescent coatings on the interior of TV cabinets may cut into this market. New FR compounds continue to use bromine, phosphorus, and antimony oxide. A market slump for UV stabilizers in the first half of 1975 now shows signs of picking up. New products include several from Borg-Warner that combine the synergistic effect of phosphites with stabilizers. 30-0011 FLAME RETARDANTS Lehmann, Edward J. FIRE RESISTANT FIBERS AND TEXTILES. A BIBLIOGRAPHY WITH ABSTRACTS NTIS/PS-74/111 This bibliography contains 124 selected abstracts of research reports retrieved using the NTIS on-line search system—NTISearch. The cited reports cover the preparation and flammability of organic flame resistant fibers and textiles. This includes flameproofing additives, flammability standards, and new cellulosic synthetic resins. [Abstr. in: Government Reports Announcements 75 (2): 95 (24 January 1975)] -117- ------- FLAME RETARDANTS See: 30-0006, Brominated Biphenyls 30-0007, Brominated Biphenyls -118- ------- 30-0012 FLUOROCARBONS Anon MORE PROPELLANTS HEAT Chem. Week HI.(13): 18 (24 September 1975) A NASA scientist offers the hypothesis that production of fluorocarbons at their current level would promote a 2 ppb concentration in the atmosphere, resulting in a 1.6°F rise in average worldwide temperature. This is above the 0.09°F change in temperature needed to cause major changes in rainfall, wind patterns, and ice cover. 30-0013 FLUOROCARBONS Stein, Lawrence HALOCARBON PROPELLANTS (Letter to Editor) Chem. Eng. News 53_ (38): 74 (22 September 1975) Halocarbons emit toxic thermal decomposition products when in contact with hot electric heating elements or when sprayed near gas, oil or wood flames (in one test, guinea pigs died in 5 to 15 minutes after exposure to gases formed when Freons 11, 12, 22, 113, and 114 were sprayed near a lighted gas stove). Also, it has been reported that metal parts in clothes driers are damaged by the hydrochloric and hydrofluoric acids resulting from the propellants in fabric softeners and antistatic conditioners. These facts prompt the writer to question the effects of fluorocarbons on the users and to urge a thorough study of their potential pulmonary hazard. -119- ------- 30-0014 FLUOROCARBONS Booz, Charles S. Jr. HALOCARBON PROPELLANTS (Letter to Editor) Chem. Eng. News 53^ (38): 74, 82 (22 September 1975) Answering the question posed by Lawrence Stein (ibid, p.74), the writer reports that Du Pont warned against using high fluorocarbon concentrations near open flames but points out that the guinea pigs, mentioned by Stein, were tested in an area that did not in the least resemble home conditions. He mentions the tests conducted by Dr. Nancy Flowers and others that offer reassurances that in normal use the concentrations of fluorocarbons are not sufficiently high to pose any great human hazard. He also states that in a Du Pont test with clothes driers an eventual malfunction was not attribu- table to the fluorocarbon propellant. 30-0015 FLUOROCARBONS Niazi, Sarfaraz and Chiou, Win L. FLUOROCARBON AEROSOL PROPELLANTS VI: INTERSPECIES DIFFERENCES IN SOLUBILITIES IN BLOOD AND PLASMA AND THEIR POSSIBLE IMPLICATIONS IN TOXICITY STUDIES J. Pharm. Sci. 64_ (9): 1538-41 (1975) When extrapolating the results of the toxic effects of fluorocarbons from animal studies to predict their toxicity in humans, the possibility of interspecies differences may be a factor to be considered, perhaps making the extrapolations less important. Interspecies differences in the absorp- tion, distribution, metabolism, and elimination of 3 fluorocarbons (dichloro- fluoromethane, dichlorotetrafluoroethane, and trichloromonofluoromethane), which are gases at 37°, may be affected by parameters important for gaseous anesthetics; e.g., the solubilities of the fluorocarbons in the blood and plasma of different species. The variations in solubilities of the 3 propel- lants in the blood (about fourfold) and in the plasma (more than 30-fold) of humans, monkeys, dogs, rats, and mice and the even greater differences in the partitioning of the compounds between blood cells and plasma indicate that significant differences in the pharmacokinetics of the fluorocarbons can be expected and should be considered in the extrapolation of toxicity data. -120- ------- 30-0016 FLUOROCARBONS Peng, Geoffrey W. and Chiou, Win L. (Letter to Editor) FLUOROCARBON AEROSOL PROPELLANTS VII: INTERACTION STUDIES WITH HUMAN AND BOVINE GLOBULINS USING PARTITION COEFFICIENT METHOD J. Pharm. Sci. 64_ (9): 1577-8 (1975) The interactions between fluorocarbons (trichloromonofluoromethane, dichloro- difluoromethane, and dichlorotetrafluoroethane) and bovine y-globulin were compared with the interactions of these compounds and human y-globulin, using the partition coefficient method. The partition coefficients in the globulin solutions were only slightly less than those in plain buffer solution, indi- cating an insignificant degree of interaction. 30-0017 FLUOROCARBONS Schwartz, Herbert BLAMES CHLOROFORM FOR OZONE DAMAGE (Letter to Editor) Household and Pers. Prod. Ind. 12. (9): 8 (1975) The writer suggests that chloroform, rather than aerosol propellants, may be helping to deplete the ozone layer. Volatile halogenated hydrocarbons formed during the chlorination of waste and drinking water evolve into the atmosphere and into the ozone layer. The amount of chlorine used in water treatment processes dwarfs the amount of Freon aerosol propellants used to date. -121- ------- 30-0018 FLUOROCARBONS Anon DU PONT REVIEWS NBS FLUOROCARBON/OZONE FINDINGS AIR/WATER Pollut. Rept. JL3_ (36): 357 (8 September 1975) While arguing that the recent NBS study on the fluorocarbon/ozone controversy offers no new information but actually casts doubt on the completeness of the computer model used to predict ozone depletion, J.P. Jesson of Du Pont acknowl- edges the importance of the finding by P.J. Ausloos and R.E. Rebbert of NBS (See: CATS *28-0004) on the effect of temperature on the breakdown of fluoro- carbons by ultraviolet light, which could change calculated vertical distribu- tions of fluorocarbons. 30-0019 FLUOROCARBONS Anon MORE TALK ON AEROSOLS Chem. Week 117 (14): 16 (1 October 1975) Public hearings were held in Madison, Wis., on a bill that proposes banning sale of aerosols by 1980, leaving time for collecting more scientific data on the fluorocarbon/ozone controversy. A Du Pont representative argued that the bill could upset Wisconsin's economy; gross sales of fluorocarbon aerosols in the state run about $45 million a year. The bill may be considered in a special November legislative session. F.J. Rowland and R.J. Cicerone appeared at the Wisconsin hearings and also before the Senate Committee on Aeronautical and Space Sciences. In Wisconsin, Rowland reported that although the atmosphere can absorb only about 25,000 tons of fluorocarbons/year, some 800,000 tons are reaching the atmosphere. Cicerone urged the committee to regulate fluorocarbons 11, 12, 113, 114, and perhaps 21 and 22. He also cautioned about possible harmful effects on the stratosphere of nitrous oxide from nitrogen-based fertilizers and the effects of other chemicals. -122- ------- 30-0020 FLUOROCARBONS Howard, Philip H. and Durkin, Patrick R. PRELIMINARY ENVIRONMENTAL HAZARD ASSESSMENT OF CHLORINATED NAPHTHALENES, SILICONES, FLUOROCARBONS, BENZENEPOLYCARBOXYLATES, AND CHLOROPHENOLS Syracuse Univ., Research Corp., N.Y., Interim Rept. (November 1973) EPA/560/2-74-001, EPA Contract 68-01-2202 (PB 238 074/9GA) A literature search of pertinent information and data on chlorinated naphthalenes, silicones, fluorocarbons, benzenepolycarboxylates, and chlorophenols was conducted to determine any hazard to man or the environment from commercial use of these chemicals. Information was gathered on physical and chemical properties, pro- duction and usage, environmental contamination, monitoring and analysis, environ- ment transport and fate, environmental effects, and toxicity. [ [Abstr. in: Government Reports Announcements 74_ (4): 78 (21 February 1975)] -123- ------- 30-0021 ISOCYANATES Anon NEW ENGINEERING PLASTIC DEVELOPED BY DOW Chem. Week 117 (13): 31 (24 September 1975) Urethane molded parts up to six inches thick can now be produced by a process developed at Dow Chemical Co. in which the thermoplastic can be cured in a minute or less. The chemical components consist of a polyol, an isocyanate, and a chemical that acts as a heat sink absorbing heat at the time of set. Packaging Machinery Corp. is making the liquid-injection-molding equipment. 30-0022 ISOCYANATES Smith, Wayne E. and La Shelle, John R. CHARACTERISTICS OF ATMOSPHERIC EMISSIONS FROM POLYURETHANE RESIN MANUFACTURE Midwest Research Institute, Kansas City, Mo., Final Rept. (October 1974) EPA/650/2-74-107, EPA Contract 68-02-0228 (PB 237 420/5GA) The report describes the characterization of air pollutant emissions from a polyurethane resin manufacturing plant. Samples were taken before and after the air pollution control device (scrubber). Analysis for toluene di-isocy- anate (TDI) and amines was conducted both on site and on a delayed basis. The sampling train included an impinger for colorimetric measurement of TDI. Cryogenic traps and a tape sampler for TDI were also used for the scrubber inlet samples. The outlet sampling manifold consisted of evacuated bulbs in place of the cryogenic traps because of the high moisture content. TDI emissions were found to be maximum in the first part of the resin formation reaction. It appears there is no emissions hazard. The scrubber had negligible effect on the TDI emissions. [Abstr. in: Government Reports Announcements 75 (2): 115 (24 January 1975)] -124- ------- 30-0023 LIQUEFACTION AND GASIFICATION OF COAL Hammond, Ogden and Zimmerman, Martin B. THE ECONOMICS OF COAL-BASED SYNTHETIC GAS Technol. Rev. 77. (8): 42-51 (July/August 1975) Considerable work has been done on the technical feasibility and process development for gasification of coal yet this product may prove to be to costly. Factors affecting the costs have not been thoroughly investigated— such as the quality of the coal which would influence fuel stock costs and the location of the deposits would influence transportation costs. Also process water requirements can prove to be very expensive. The benefits of the heat pump, operated by electricity and modified for use in space heating may prove to be the least expensive method. 30-0024 LIQUEFACTION AND GASIFICATION OF COAL Anon SUIT COOLS COAL PLANS Chem. Week 117 (14): 13 (1 October 1975) Coal mining operations of Federal lands under lease in the Northern Great Plains region have been affected by the U.S. District Court's decision that environ- mental impact statements will be required before the leases are granted. Exxon's Carter Oil affiliate, and Shell Oil (Crow Indian Reservation) have suspended operations as a result of the court's decision. -125- ------- 30-0025 LIQUEFACTION AND GASIFICATION OF COAL Kalfadelis, C.D. and Magee, E.W. EVALUATION OF POLLUTION CONTROL IN FOSSIL FUEL CONVERSION PROCESSES. GASIFICATION. SECTION I. SYNTHANE PROCESS. Esso Research and Engineering Co., Linden, N.J., Final Rept. June 1974 Environmental Protection Technology Series GRU.4DJ74 EPA/650/2-74-009b, EPA Contract 68-02-0629 (PB 237 113/6GA) The report gives results of a review of the U.S. Bureau of Mines' Synthane Coal Gasification Process from the standpoint of its potential for affecting the environment. Where possible, it estimates the quantities of solid, liquid, and gaseous effluents, as veil as the thermal efficiency of the process. It proposes a number of possible process modifications or alternates, and points out new technology needs. (Abstract in: Government Reports Announcements 75. (2): 114 (24 January 1975)] 30-0026 LIQUEFACTION AND GASIFICATION OF COAL Ball, D., et al STUDY OF POTENTIAL PROBLEMS AND OPTIMUM OPPORTUNITIES IN RETROFITTING INDUSTRIAL PROCESSES TO LOW AND INTERMEDIATE ENERGY GAS FROM COAL Battelle Columbus Labs., Ohio, Final Rept. May 1974, Environmental Protection Technology Series EPA/650/2-74-052, EPA Contract 68-02-1323 (PB 237 116/9GA) The report compiles background information, including environmental considera- tions, on the potential for retrofitting existing industrial processes to the use of low and intermediate energy gas from coal. Potential problems in retro- fitting processes are analyzed. Processes where retrofit is most attractive are identified, along with estimates of their annual energy requirements. Also, current commercially available gasification systems and representative gas cleanup systems are described and available data summarized. [Abstract in: Government Reports Announcements 75. (2): 114 (24 January 1975)] -126- ------- 30-0027 LIQUEFACTION AND GASIFICATION OF COAL Shaw, H. and Magee, E.M. EVALUATION OF POLLUTION CONTROL IN FOSSIL FUEL CONVERSION PROCESSES. GASIFICATION: SECTION 1. LURGI PROCESS. Exxon Research and Engineering Co., Linden, N.J., Final Rept. July 1974 GRU.5DJ.74 EPA/650/2-74-009-C, EPA Contract 68-0629 (PB 237 694/5GA) A process analysis of the Lurgi Dry Ash Gasification Process for high Btu gas was carried out. The process has been reviewed from the standpoint of its potential for affecting the environment. The waste stream compositions were calculated for a 250 MM scfd synthetic natural gas plant using a subbituminous coal. Thus, the quantities of solid, liquid, and gaseous pollutants were estimated, where possible. The thermal efficiency for various process alter- natives was calculated. A number of process modifications which would reduce pollution and/or increase thermal efficiency were suggested. The technology needs to control pollution were assessed. [Abstract in: Government Reports Announcements 75 (3): 52 (7 February 1975)] -127- ------- 30-0028 MODEL ECOSYSTEMS Blau, G.E. et al ECOKINETICS: A STUDY OF THE FATE AND DISTRIBUTION OF CHEMICALS IN LABORATORY ECOSYSTEMS AICHE J. 21_(5) : 854-61 (September 1975) A laboratory scale ecosystem can be used to study different amounts and forms of a chemical in the environment by the analysis of the kinetic transformation within and between the different components of the model system. Samples are collected at various times and information obtained on a sequence of concentrations of the chemical and its metabolites as it moves through the system while observing the kinetic behavior. These data can be used as a quantitative measure to assess environmental impact. 30-0029 MODEL ECOSYSTEMS Lu, Po-Yung et al EVALUATION OF ENVIRONMENTAL DISTRIBUTION AND FATE OF HEXACHLOROCYCLOPENTADIENE, CHLORDENE, HEPTACHLOR, AND HEPTACHLOR EPOXIDE IN A LABORATORY MODEL ECOSYSTEM J. Agric. Food Chem. 2_3 (5): 967-73 (September/October 1975) Results of a study on the distribution and degradation products in a model ecosystem for chlordene, heptachlor and heptachlor epoxide show that heptachlor epoxide is highly stable in biological systems. The compounds were evaluated in food chain organisms in two laboratory model ecosystems and in vitro by sheep liver chromosomes. -128- ------- 30-0030 MODEL ECOSYSTEMS Yu, Ching-Chieh et al FATE OF TRIAZINE HERBICIDE CYANAZINE IN A MODEL ECOSYSTEM J. Agric. Food Chem. 23_ (5): 1014-15 (September/October 1975) Carbon 14 labelled Cyanazine was used in a 35 day degradation study in a model ecosystem. Radioactivity in the water increased steadily over the test period indicating slow degradation of the triazine ring to carbon dioxide. However, no evidence was found in the aquatic organisms to indicate that cyanazine concentrates through the food chain. 30-0031 MODEL ECOSYSTEMS Lacaze, Jean-Claude MARINE MOLYSMOLOGY: THE PRIMARY PRODUCTION OF EXPERIMENTAL ECOSYSTEMS SET UP IN THE RANGE RIVER ESTUARY. EFFECT OF CRUDE OIL EPA-TR-86-75 November 1974 (EPA Translating Services Section) Trans, of Academie des Sciences, Paris, Comptes Rendus (France) 278: 2531-34 (May 13, 1974) (PB 237 777-T/GA) Crude oil (Kuwait) discharged into experimental ecosystems resulted in a sharp 50% decrease in primary production the day after pollution. This began to lessen the following day (25%) and disappeared on the third day. The fourth day marked the onset of toxicity which gradually increased until primary pro- duction was almost totally inhibited one week after pollution. This inhibition phase lasted ten days. During the rest of the experimental period, the primary production of the polluted ecosystems was approximately half that of the control ecosystem. [Abstract in: Government Reports Announcements 75 (3): 40 (7 February 1975)] -129- ------- 30-0032 NITRILOTRIACETIC ACID (NTA) Anon NTA STILL ANOTHER REPORT Household and Pers. Prod. Ind. 12. (9): 8 (1975) HEW has issued a second final report from its NTA subcommittee. They feel that the available evidence is indicative of a carcinogenic effect on the urinary tract in both rats and mice. However, test dosages for rats was 400,000 times as great as human exposure would be. -130- ------- OPTICAL BRIGHTENERS See: 30-0010, Flame Retardants -131- ------- 30-0033 PHTHALATES Piekacz, Hanna THE EFFECT OF DIBUTYL- AND DIOCTYL-PHTHALATES ON RATS WITH ORAL FEEDING DURING PROLONGED TESTING. PART I. APPLICATION AND TOXICOLOGICAL PROPERTIES OF DIBUTYL- AND DIOCTYL-PHTHALATES Trans, of Roczniki Panstwowego Zaklada Higieny (Poland) 22; 55-61 (1971) The use of dibutyl- and dioctyl-phthalates Is discussed a propos of legislation In various countries, as well as their toxicological properties. This study serves as an introduction to research on hyperacute and extended toxicity of both phthalates. [Abstract in: Government Reports Announcements 75 (3): 50 (7 February 1975)] 30-0034 PHTHALATES Williams, David T. and Blanchfield, Burke J. THE RETENTION, DISTRIBUTION, EXCRETION, AND METABOLISM OF DIBUTYL PHTHALATE-7~l4C IN THE RAT J. Agric. Food Chem. 23 (5): 854-8 (September/October 1975) Dibutyl phthalate did not accumulate in the tissues or organs of rats fed for 12 weeks on one gram of compound/kilogram of feed. In a study using DBP-7- C, 93.5% of the radioactivity was excreted from the urine within 48 hours. Auto- radiography revealed one major metabolite and three minor metabolites. No gross pathological changes were evident in the tissues. -132- ------- POLYURETHANES See: 30-0021, Isocyanates -133- ------- 30-0035 VINYL CHLORIDE Anon NEW POLYESTER TAKES ON PVC IN PACKAGING Chem. Eng. News 53_ (38): 6 (22 September 1975) A new polyester material suitable for food packaging meets the CFR food additive regulation 21, and has been accepted by the Dept of Agriculture for packaging meat and poultry. The tradename for Eastman Chemicals new product is Kodar, and it appears to have many advantages over rigid PVC in blister packaging. 30-0036 VINYL CHLORIDE Mack, W.A. VCM REDUCTION AND CONTROL Chem. Eng. Prog. 21 (9): 41-4 (1975) An effective method for removing vinyl chloride monomer from the polymer resin has been developed. This is done in the mixer before processing. It combines an aspirator fitted to the mixer to draw the monomer laden air from the mix and an air stripping step in which air passes upward through the material taking out additional VCM from the mix. The basic research development, and method resulted from a joint research program of Imperial Chemicals Industries, Ltd. and T.K. Fielder, Ltd. -134- ------- 30-0037 VINYL CHLORIDE Bell, Z.G. Jr., et al CONTROL METHODS FOR VINYL CHLORIDE Chem. Eng. Prog. H. (9): 43-7 (1975) Methods for protecting personnel at PPG Industries vinyl chloride plants include a means of collecting quality control samples in a bomb, making the analyses in a hood, and returning the unused portion of the VC sample to the processing operation so that the monomer is confined. A precise, closed routine is followed for loading the product into tank cars and ships. High pressure nitrogen is used in the plant where purging operations are needed to prevent escape of the gas. 30-0038 VINYL CHLORIDE Wheeler, R.N. Jr., and Sutherland, M.E. CONTROL OF IN-TRANSIT VCM Chem. Eng. Prog. _71 (9): 48-53 (1975) To meet VCM regulations, special devices, equipment, and systems will have to be provided. Gauging devices will need to be installed on tank trucks, tank cars and barge tanks. One which has worked well on tank cars is a float magnetically coupled to a tape system. Tank car size of new cars is being limited to 25,500 gallons. Pipe lines will require regular monitoring for leaks, Scavenging systems will be required to strip off vinyl chloride liquid or monomer when the need arises. Inert gas purging of scavenged equipment will remove the last traces of the monomer. Finally, automation is the best approach to control of personnel exposure to vinyl chloride according to Union Carbide Corp. -135- ------- 30-0039 VINYL CHLORIDE Mantell, G.J. et al STRIPPING VCM FROM PVC RESINS Chem. Eng. Prog. TL (9): 54-62 (1975) A description of the stripping techniques being studied at Air Products and Chemicals, Inc. covers removing the VC monomer from aqueous slurries - the suspension process - in the polymerization reactor or in a special stripping vessel. Variables that affect the process are time, temperature, and pressure. The vinyl chloride which is removed is prepared for reuse by compression and condensation. 30-0040 VINYL CHLORIDE Severs, L.W. and Skory, L.K. MONITORING PERSONNEL EXPOSURE TO VINYL CHLORIDE, VINYLIDENE CHLORIDE AND METHYL CHLORIDE IN AN INDUSTRIAL WORK ENVIRONMENT Am. Ind. Hyg. Assoc. , J. J3l5 (9): 669-76 (September 1975) The use of activated carbon as an adsorbent is suggested for personnel monitoring in areas where workers are exposed to vinyl chloride, vinylidene chloride, and methyl chloride. A satisfactory method of desorbing the carbon while insuring the integrity of the VC sample was to use carbon disulfide at dry ice temperature. -136- ------- 30-0041 VINYL CHLORIDE Anon PHS TO URGE MORE RELIANCE ON SCIENCE FOR HEALTH PROTECTION AGAINST VINYL CHLORIDE: Environ. Health Lett. 14 (18): 4 (15 September 1975) EPA is in the process of setting vinyl chloride standards for the general public. HEW is said to have suggested the need for more scientific methods as a basis for establishing these limits. However, this would require considerable addi- tional research. A major concern of these agencies is the safety of people living in the vicinity of plants using vinyl chloride or polyvinyl chloride. -137- ------- VINYLIDENE CHLORIDE See: 30-0040, Vinyl chloride -138- ------- 30-0042 GENERAL INFORMATION Sikka, Harish C. et al UPTAKE, DISTRIBUTION, AND METABOLISM OF ENDOTHALL IN FISH J. Agric. Food Chem. 23 (5): 849-51 (September/October 1975) Bluegills absorbed less than 1% of the herbicide, endothall, from water containing 2 ppm endothall/500 ml water, during a 96-hr exposure. Concentration of endothal was highest in the viscera and lowest in the flesh. Concentration in the viscera started to decline after 24 hours, indicating distribution to other tissues. Endothal, when fed to ^b'Jluegills through the digestive tract, was absorbed by the intestinal tract1,-' but 73% was eliminated during the 48-hr test period. Again, the concentration was highest in the viscera, lowest in the flesh. Unlike aquatic microorganisms, bluegills apparently cannot metabolize this herbicide. 30-0043 GENERAL INFORMATION Anon AMERICAN CYANAMID IS ENTERING A BIG HERBICIDE MARKET. . . Chem. Eng. News 5.3 (38): 14 (22 September 1975) New from American Cyanamide is Prowl, a dinitroaniline compound aimed at the $400 million corn and cotton herbicide market. The company expects to be on stream by 1978 in Hannibal Mo., plant now being built; meanwhile, contract manufacturers are being used. -139- ------- 30-0044 GENERAL INFORMATION Burke, Donald P. METHANOL Chem. Week 117 (13): 33-7, 39-42" (24 September 1975) Review discusses potential uses, technology, and economics of methanol for various fuel purposes: regasification to methane, fuel for gas turbines, or in motor fuels. Another potential use, as a source for single-cell protein, could use up to 33,000 tons/day by 1980. 30-0045 GENERAL INFORMATION Anon EPA PLANS TO STUDY NITROSAMINES IN AIR Chem. Eng. News 53 (39): 7 (29 September 1975) From 0.014 to 0.96 ppb of dimethyl nitrosamine have been detected in the ambient air in several eastern cities. The nitrosamines may arise from industrial processes or they may be forming from atmospheric reactions of nitrogen oxides and amines. EPA will study nitrosamines in air, and will also include them in current studies of drinking water contaminants. -140- ------- H'>" 30-0046 GENERAL INFORMATION Anon HEXAMETHYLPHOSPHORAMIDE CAUSES CANCER IN LABORATORY ANIMALS. . . Chem. Eng. News 53 (39): 17 (29 September 1975) In studies at Du Font's Haskell Labs., Newark, Del., rats developed cancer after inhaling HMPA vapor for six to eight months. The chemical is used as a laboratory solvent and in synthetic fiber manufacture. As yet, there is no evidence of cancer in other animals and no adverse health effects have been noted in workers at Du Font's Deepwater, N.J., plant, where the chemical is made, or at the Richmond, Va., plant, where it is used. 30-0047 GENERAL INFORMATION Brown, Stephen M. et al EFFECT ON MORTALITY OF THE 1974 FUEL CRISIS Nature 257 (5524) : 306-7 (25 September 1975) First-quarter 1974 mortality rates were down in San Francisco County and Alameda County over first-quarter 1973 rates. The period: of decreased death rates coincides with a period in which retail gasoline sales were down 9.5%. -141- ------- 31-0001 ARSENIC Copenhaver, E.D. and Wilkinson, B.K. TRANSPORT OF HAZARDOUS SUBSTANCES THROUGH SOIL PROCESSES. Vol. I. ARSENIC, BERYLLIUM, CADMIUM, ZINC, AND OTHERS ORNL-EIS-74-70 (Pt. 1). Oak Ridge Natl. Lab., Contract W-7405-eng-26 (November 1974) This bibliography is intended for use by personnel concerned, cither via research or management, with the disposal of hazard- ous wastes, other than sewage sludge, on land. It is the result of a search of recent literature and Includes Information on the transport, transformation, and soil retention of arsenic, asbestos, beryllium,' cadmium, chromium, copper, cyanide, lead, mer- cury, selenium, zinc, halogenated hydrocarbons, pesticides, and other hazardous substances. The literature search focused on processes directly related to transport (adsorption, ion ex- change, etc.) and documentation of the occurrence and extent of transport while specifically excluding topics such as uptake and translocation by plants, theoretical modeling, and effects on microorganisms and processes mediated by microorganisms. [Abstract in: Nuclear Sci. Abstrs. 3d (5): 1139 (15 March 1975)] 31-0002 ARSENIC Copenhaver, E.D. and Wilkinson, B.K. TRANSPORT OF HAZARDOUS SUBSTANCES THROUGH SOIL PROCESSES. VOL. 2. PESTICIDES. ORNL-EIS-74-70 (Pt. 2).. Oak Ridge Natl. Lab., Contract W-7405-eng-26 (November 1974) This bibliography Is intended lor use by personnel concerned, either via research or management, with the disposal of hazard- ous wastes, other than sewage sludge, on land. Information on the transport, transformation, and soil retention of :i. num'ier ol hazardous substances Is presented in Volume 1. TMs volume contains citations on pesticides and detailed information on chemical nomenclature and structures of pesticides is appended to this volume. [Abstract in: Nuclear Sci. Abstrs. _31. (5): 1139 (15 March 1975) -142- ------- 31-0003 ASBESTOS Anon OSHA PROPOSES MORE TOXIC SUBSTANCE RULES Chem. Eng. News 53_ (40): 8 (6 October 1975) OSHA's proposed new occupational standard for asbestos, which would revise the standard of 7 June 1972, calls for a reduction in the permissible exposure for an 8-hr period to only 0.5 fiber/cc instead of 5, and a reduction in the 15- minute ceiling exposure limit to 5 fibers/cc instead of 10. Retention of monitor- ing and medical records would cover a 40-year period or would be for the duration of the worker's employment plus 20 years, whichever is longer. This is another drastic change, the current retention period being 3 years for monitoring records and 20 years for medical records. Drastic reductions are also being proposed for lead and toluene. 31-0004 ASBESTOS Harwood, Colin F. and Blaszak, Thomas P. CHARACTERIZATION AND CONTROL OF ASBESTOS EMISSIONS FROM OPEN SOURCES IIT Research Inst. Contract EPA-68-02-1348. Final Rept., June 1973-May 1974 (September 1974), IITRI-C6290-11, EPA/650/2-74-090. PB-238" 9'25/2GA. The report reviews control technology applica- ble to asbestos emissions from open sources including asbestos mines, mills, and manufac- turing waste piles. It combined a literature review with visits to asbestos mining and manu- facturing operations, and considered cli- matology, location, and topography. The study, which included preliminary field sampling, produced a comprehensive bibliography on emissions control. The health effects of asbestos exposure were reviewed from two aspects: the significance of fiber size, and the effect of non-occupational exposure. Fiber size considered to be most harmful is still not established and, while non-occupational expo- sure probably does not lead to asbestosis, evidence relates it to increased incidence of cancer. Data analyses indicated that asbestos can be detected at considerable distances from a given source. It was concluded that, because of their proximity to populations, asbestos manufacturing waste piles are a threat to public health more serious than asbestos mining. [Abstract In: Government Reports Announcements 21 <8): 145 (18 April 1975) -143- ------- 31-0005 ASBESTOS Igwe, Basil U.N. ECONOMIC ANALYSIS OF EFFLUENT GUIDELINES FOR THE ASBESTOS INDUSTRY Arthur D. Little, Inc. Contract EPA-68-01-1541. Final Kept. (December 1974), ADL-C-75934-04, EPA-230/2-74-001. PB-238 268/7GA An analysis was made of the potential economic impact on the asbestos products manufacturing industry due to the implementation of the effluent limitations standards formulated in compliance with the 1972 Federal Water Pollution Control Act Amendments. The industry is not expected to suffer major adverse impacts under both standards as measured by loss of production, unfavorable price structure, employment curtailment, etc. [Abstract in: Government Reports Announcements 75 (6): 126 (21 March 1975)] ASBESTOS See: 31-0001, Arsenic See: 31-0002, Arsenic -144- ------- 31-0006 BENZIDINE Radding, Shirley B. et al REVIEW OF THE ENVIRONMENTAL FATE OF SELECTED CHEMICALS Stanford Res. Inst. Contract EPA-68-01-2681, Final Rept. on Task 1 (10 January 1975), EPA/560/5-75-001, PB-238 908/8GA A search of the scientific literature and an evaluation of such literature on the environmental fate of the following compounds has been reported: benzidine and its salts; 3,3'-dichlorobenzidine; 1-naphthylamine; propiolactone; 4,4'-methyl- enebis(2-chloroaniline); ethylenimine; and bis(chloromethyl)ether. Some intelligent guessing based on structural analogies for the chemicals is made where little information was available. These chemicals are known carcinogens but little is known of their environmental fate. Emphasis is placed on reporting or estimating kinetic values for potentially important pathways of degradation. In cases where no data were available, independent calculations for free radical reactivity were made. [Abstract in: Government Reports Announcements _75_ (8): 72 (18 April 1975)] -145- ------- 31-0007 BORON Weeth, H.J. and Green, G.H. AN ECOLOGICAL INVESTIGATION OF THE ACCURACY OF THE FEDERAL STANDARD OF PERMISSIBLE BORON LEVELS TO WATER RESOURCES Nevada Univ., Center for Water Resources Research. Contract DI-14-31-0001-4028 W75-02889, OWRT-A-053-NEV (4) (October 1974), PB-238 298/4GA The purpose was to determine If the Environ- mental Protection Agency's proposed max- imum acceptable concentration of 5 mg/l boron In livestock water is realistic. Twelve Hereford heifers were tested in thirty-day periods. Total daily boron intakes were 215, 4224, and 7219 mg. with tap water, 150 mg/l boron-water and 300 mg/l boron-water treat- ments, respectively. Renal clearance and/or reabsorption estimates were made on craatinlne, osmolites, free water, sodium, phosphate and boron. Effects of treatments on dally urine weight, total dissolved solids, osmotic pressure, sodium, potassium, phosphate and boron were also evaluated. The results showed that the cattle were able to tolerate the high concentration of boron with no permanent effects. The heifers did, however, lose weight, showed a tendency for erythe- matous swelling, and the concentrations of plasma phosphate were significantly reduced while plasma boron concentrations were higher. The study indicates that cattle can tolerate at least one order of magnitude more boron In their drinking water than the 5 mg/l limit set by the Environmental Protection Agen- cy with no ill effects. [Abstract in: Government Reports Announcements _75_ (?) : 8 (4 April 1975)] -146- ------- 3,3'-DICHLOROBENZIDINE See: 31-0006, Benzidine -147- ------- ETHYLENIMINE See: 31-0006, Benzidine -148- ------- 31-0008 FLAME RETARDANTS Anon FR: GREAT LAKES Am. Dyest. Rep. 64 (9): 69 (1975) Great Lakes Chemical Corp's two new brominated acrylate monomers, 2,3-dibromo- propyl acrylate and 2,3-dibromopropyl methacrylate (trade-named Great Lakes AE-59 and Great Lakes Me-56, respectively) are specially designed for flame retardant coatings and plastics. A variety of potential applications is claimed. 31-0009 FLAME RETARDANTS Donaldson, D.J. et al FLAME RETARDANT FOR 50/50 POLYESTER/COTTON WOVENS Am. Dyest. Rep. 64^ (9): 30 (1975) From 1 Sept. 1976 through 1981, CPSC will add six flame-retardant standards for clothing made chiefly from 50/50 polyester/cotton blends. Recently, a tetrakis (hydroxymethyl)phosphonium chloride-urea-poly(vinyl bromide) (THPC-urea-PVB) proved to be an effective flame retardant for this blend except that it caused the fabric to turn yellow, when cured. To counteract this effect, a vinyl bromide/vinyl chloride (slightly more bromide than chloride) latex was formulated for incorporation into the THPC-urea-PVB emulsion. Reflectance tests indicate that the new THPC-urea-PVB-PVC formulation overcomes the discoloration problem while still maintaining its effective flame-retardancy properties. -149- ------- 31-0010 FLAME RETARDANTS Le Blanc, R. Bruce et al NEW PHOSPHORAMIDE DERIVATIVES AS FLAME RETARDANTS FOR COTTONS Text. Chem. Color. ]_ (10): 172/23-174/25 (1975) The most widely used flame retardants for cottons, Pyrovatex CP and tetrakis (hydroxymethyl)phosphonium salts (THP salts) are not effective for all end uses. To find an inexpensive finish providing cottons with flame retardance and durable press properties that could be maintained under various laundering conditions, tests were made with various phosphoramide derivatives, prepared by reacting tetramethylphosphorodiamidic chloride with ammonia and different amines and amides. The most satisfactory compound was pentamethylphosphorotriand.de, which was less costly and an effective flame retardant, when methylolated and applied to cotton with triazine resins. -150- ------- 31-0011 FLUOROCARBONS Anon NBS RESEARCH DETAILS FLUOROCARBON BREAKDOWN IN UPPER ATMOSPHERE J. Air Pollut. Control Assoc. 25 (10): 1060-1 (1975) Drs. P.J. Ausloos and R.E. Rebbert of NBS made public at the recent ACS Chemical Society meeting in Chicago their studies on the breakdown of fluorocarbons by sunlight in the earth's upper atmosphere and the effects of temperature on this breakdown. Additional details of their research are presented here, but a fuller accounting will be published later in the "Journal of Photochemistry." 31-0012 FLUOROCARBONS Huebner, Russell H. et al ULTRAVIOLET PHOTOABSORPTION BY HALOCARBONS 11 AND 12 FROM ELECTRON IMPACT MEASUREMENTS Nature 257 (5525) : 376-8 (2 October 1975) Electron energy-loss spectra were obtained for F-ll (CFC^) and F-12 (CF2 using the NBS model AN-1 electron impact spectrometer. Energy absorption results relevant to the ozone depletion problem are presented. The data confirm the measurements of Rowland and Molina, but differ from other published data. -151- ------- 31-0013 FLUOROCARBONS Ramanathan, V. GREENHOUSE EFFECT DUE TO CHLOROFLUOROCARBONS: CLIMATIC IMPLICATIONS Science 190 (4209): 50-2 (3 October 1975) A new theory is presented describing the effects of chlorofluorocarbons on the earth's thermal energy balance. Chlorofluorocarbons (e.g., fluorocarbon propellants 11 and 12) and chlorocarbons have strong infrared bands capable of absorbing radiation from the earth's surface and emitting it at the lower atmos- pheric temperature, thus causing a reduction in the net infrared radiative flux emitted to space by the earth-atmosphere system. This "greenhouse" effect tends to increase surface and atmospheric temperatures. The theory which is postulated on a very simplified model of the atmosphere and considers only those bands in the 8 to 12 ym region, suggests an increase in mean global surface temperature of at least 0.9°K by the year 2000, if the concentrations of F-ll and F-12 are each increased to 2 ppb. 31-0014 FLUOROCARBONS Marchio, J.L. and Quick, Q. ODOR PROBLEMS WITH PROPELLANT BLENDS Soap, Cosmet. Chem. Spec. 53^ (9): 64-6, 89-90 (1975) An analytical study to determine the cause of an unpleasant odor reported in an aerosol propellant containing blends of fluorocarbons 11 and 12 inhibited with nitromethane is reported. The malodor is produced only when nitromethane, iron, water and HC1 are present. The breakdown of the fluorocarbon, during corrosion, is one possible source of HC1. The odiferous compounds were identified primarily as oximes. -152- ------- 31-0015 FLUOROCARBONS Leromer, Francis S. and Allen, Sylvester T. FIRE EXTINGUISHING PROPERTIES OF CHLORODIFLUOROMETHANE Army Tank-Automotive Command, Warren, Mich. Tech. Rept.TACOM-TR-11926 (June 1974), AD/A-003 993/3GA The fire extinguishing properties of chlorodifluoromethane were measured by using a propane gas burner fed with oxygen enriched air. The bench test employed controlled burner temperature, air and fuel pressure. Time to extinguish and quantity of chlorodifluoromethane used were the principal criteria for establishing extinguishing properties. Chlorodifluoromethane proved to be equal to another popular halogenated hydrocarbon, monobromotrl- fluoromethane. [Abstract in: Government Reports Announcements 75_ (6): 139 (21 March 1975)] 31-0016 FLUOROCARBONS Anon A MATHEMATICAL COMPUTER MODEL SIMULATING THE OZONE REGION Chem. Eng. News 53 (4): 16 (6 October 1975) University of Wisconsin meteorologists will use a computer model simulating the stratospheric ozone region to study such effects of nitrous oxide and chloro- fluorocarbons as the impact of reflected and scattered sunlight on ozone-layer chemistry. The model makes it possible to follow the night/day changes in chemical concentrations. -153- ------- 31-0017 FLUOROCARBONS Anon OZONE CONTROVERSY CASTS GLOBAL SHADOW Chem. Week ll]_ (16): 47-8 (15 October 1975) The ozone controversy dominated the recent 10th annual International Aerosol Conference in London. The European aerosol market has had slow sales and a lack of new products. Heard at the meeting: The World Meteorological Organization reports that a 2% ozone-depletion by chlorofluorocarbons has increased UV radiation at the ground level and this increase will reach 40%, at an unspecified time. Possible propellant alternatives to F-ll and F-12 are F-21 (dichlorofluoromethane), F-22 (chlorodifluorometbane) and methylene chloride. F-22, already a production item, is reputedly less toxic than F-ll and F-12, but the toxicity of F-21 is not yet well established. On the other hand, F-21 and F-22 were mentioned by R.J. Cicerone as possible candidates for regulation, when he asked the Senate Subcommittee on the Upper Atmosphere to recommend regulation of F-ll, F-12, F-113, and F-114. 31-0018 FLUOROCARBONS Anon RESEARCH CONTINUES ON STRATOSPHERIC MODIFICATION BY FREON DECOMPOSITION: DETAILS OF THE MECHANISM ARE REPORTED Res./Dev. 2£ (10): 8 (1975) The Manufacturing Chemists Association has added 7 new contracts for research on the effects of fluorocarbons on the Earth's atmosphere. Ten other studies are already underway in this $l.l-million program, which is expected to total about $5-million over a 3-year period. -154- ------- 31-0019 FLUORO.CARBONS Anon STATE AEROSOL ACTIONS Soap, Cosmet. Chem. Spec. 51 (9): 20 (1975) New York and Louisiana have enacted legislation to restrict the sale of chloro- fluorocarbon compounds, calling for special labels and imposing other regulations. California wants the President and Congress to make ingredient and percentage composition labeling mandatory. Massachusetts, Michigan, New Jersey, Ohio, and Pennsylvania are also proposing bills to control or ban the sale of aerosol products. -155- ------- HALOETHERS See: 31-0006, Benzidine -156- ------- 31-0020 HEXACHLOROBENZENE Lissner, Reinhard et al HEXACHLOROBENZENE-INDUCED PORPHYRIA IN RATS — RELATIONSHIP BETWEEN PORPHYRIN EXCRETION AND INDUCTION OF DRUG METABOLIZING LIVER ENZYMES Biochem. Pharmacol. 24_ (18): 1729-31 (15 September 1975) Urinary excretions of the porphyrins and 5-aminolaevulinic acid (ALA) by rats were found to be abnormal after the 40th day of feeding on diets containing HCB. Cytochrome P-450 content in the liver was elevated during the first week, then stayed constant until the 30th day before rising again. Aniline hydroxylase activity followed a similar pattern. It is suggested that a metabolite is probably formed from the oxidation of HCB and that this metabolite may be the actual porphyrogenic agent. -157- ------- 31-0021 HYDRAZINE Gormley, William T. DISTRIBUTION CHARACTERISTICS OF METHYLHYDRAZINE IN THE PLASMA AND CEREBROSPINAL FLUID OF MONKEYS Aerospace Med. Res. Lab., WPAFB, Ohio. Rept. No. AMRL-TR-74-39 (1974), AD/A-005 529/3GA [Also in: Aviation, Space and Environ. Med. 4£ (1): 64-8 (1975)] A lumped parameter mathematical model including extracellular fluid, intra- cellular fluid, and cerebrospinal fluid compartments has been applied to describe methylhydrazine (MMH) distribution kinetics in the blood and cerebrospinal fluid of Rhesus monkeys. Ten monkeys, average weight 5.5 kg, were given intravenous infusions of MMH while blood and cerebrospinal fluid samples were periodically collected and analyzed for MMH. The mathematical model was used to simulate the infusions and the simulations were compared with experimental data to validate the model and to evaluate the mass transfer parameters required by the model [Abstract in: Government Reports Announcements _75_ (8): 66 (18 April 1975)] -158- ------- 31-0022 LIQUEFACTION AND GASIFICATION OF COAL Ayer, Franklin A. SYMPOSIUM PROCEEDINGS: ENVIRONMENTAL ASPECTS OF FUEL CONVERSION TECHNOLOGY (MAY 1974, ST. LOUIS, MISSOURI) Research Triangle Inst. Contract EPA-68-02-1325. Final Rept. (Oct. 197A) , EPA/650/2-74-118 This document is the final report covering EPA's symposium to review and discuss environmentally related information of coal conversion technology. More specifically, papers were presented that covered environmental quality and standards, fuel contaminants, environmental aspects of specific fuel conversion systems, fuel utilization and total environmental assessment, and research and development needs. [Abstract in: Government Reports Announcements 75_ (8): 139-40 (18 April 1975)] 31-0023 LIQUEFACTION AND GASIFICATION OF COAL Downs, W. Richard and Cox, Kenneth E. COAL CONVERSION AND USAGE: A SYSTEMS STUDY NASA-TM-X-58157; JSC-09260 (November 1974) A comprehensive study of coal conversion and usage is presented, with emphasis on its possibilities as an interim energy source between the phaseout of petroleum and natural gas and the wide use of solar energy. Several projections of energy demands into the 21st century are included. Possibilities for the use of coal both for conversion into a variety of gas and solid fuels and for firing electric powerplants are analyzed and costs of coal-based energy, based on current tech- nology, are discussed. A few specific methods of conversion are recommended for further research and development. Some ways to overcome environmental problems both in mining and in burning coal are also mentioned. [Abstract in: STAR 13_ (3): 317 (8 February 1975) -159- ------- 4,4'-METHYLENEBIS(2-CHLOROANILINE) See 31-0006, Benzidine -160- ------- NAPHTHYL AMINES See: 31-0006, Benzidine -161- ------- 31-0024 PERCHLOROETHYLENE Anon ETHYL WILL DISCONTINUE TRICHLOROETHANE PRODUCTION Chem. Week 117 (16): 15 (15 October 1975) After 1 April 1976, when current production amounts and inventories are expected to be exhausted, Ethyl will be out of the 1,1,1-trichloroethane business. The company has not decided on the final disposition of its 50-million-lbs/year unit at Baton Rouge, La. Production and marketing of perchloroethylene and trichloro- ethylene will continue. -162- ------- 31-0025 PHTHALATES Daniel, J.W. and Bratt, H. THE ABSORPTION, METABOLISM AND TISSUE DISTRIBUTION OF DI(2-ETHYLHEXYL) PHTHALATE IN RATS Toxicology 2_: 51 (1974) After a single oral dose of carbon-labelled DEHP (2.0 mg/kg), rats excreted 42% of the radioactivity in the urine and 57% in the feces within 7 days; about 14% was excreted via the bile. Rats given a dose of radioactive DEHP, excreted 57% of the radioactivity in the urine, 38% in the feces, and 9% in the bile. On a 35-day diet of 1000 ppm of carbon-labelled DEHP, radioactivity in the liver reached the equivalent of 40-50 ppm DEHP in about one week: the level in abdominal fat reached 7-9 ppm within 2 weeks. Tests were also made at the 5000 ppm diet level. The action of carbon-labelled DEHP, given intravenously, was followed in the blood, liver, lungs, and in the excretion products of the rats. [Abstract in: Food Cosmet. Toxicol. 13_ (3): 398-9 (June 1975)] 31-0026 PHTHALATES Stein, M.S. et al INFLUENCE OF DIETARY FAT AND DI-2-ETHYLHEXYL PHTHALATE ON TISSUE LIPIDS IN RATS J. Nutr. 104; 187 (1974) Rats were fed a fat-free diet plus either 0.1% DEHP or 4% stripped lard, or both, for 44 days. The DEHP increased liver weight by itself and in combination with lard. DEHP enhanced the growth-promoting effect of the lard, judging from body-weight gain. Given alone, DEHP caused an insignificant reduction in total body weight gain. DEHP accumulated in the heart and epididymal fat pad, but not in the liver. In combination with lard, DEHP increased the total lipid content of the liver. Evidently, dietary DEHP has an influence on lipid metabolism. [Abstract in: Food Cosmet. Toxicol. 13 (3): 398-9 (June 1975)] -163- ------- 31-0027 POLYURETHANES Osawa, Zenjiro et al STUDY OF THE DEGRADATION OF POLYURETHANES. II. ESR STUDY ON THE PHOTODECOMPOSITION OF POLYURETHANES AND ETHYLPHENYLCARBAMATE J. Polym. Sci., Lett. Ed. 13 (9): 535-42 (1975) The photodecomposition mechanism of polyurethanes and a model urethane system (ethylphenylcarbamate) on the basis of the ESR and mass spectral data are described. The main gaseous products are carbon dioxide and carbon monoxide. Degradation occurs through cleavage of the N-C and C-0 bonds in the urethane group. -164- ------- BETA-PROPIOLACTONE See: 31-0006, Benzidine -165- ------- TRICHLOROETHYLENE See: 31-0024, Perchloroethylene -166- ------- 31-0028 VINYL CHLORIDE Anon WANTED: SUBSTITUTES FOR PVC Chem. Week 117 (15): 47-8 (8 October 1975) The Packaging Institute recently sponsored a seminar on replacement materials for polyvinyl chloride. Producers were cautioned by Dr. Seymour Gilbert, Rutgers University, Dept. of Food Science, that various substitute materials such as co-polyesters, acrylic-based polymers and nitrile resins may have to handle problems as to monomer migration, like those encountered with PVC. The FDA may have established fixed rules on monomer migration within a year. Bruce Kemp of the plastics dept of ICI, United States, predicted that 40% of the market for vinyl packaging materials will go to substitute materials. 31-0029 VINYL CHLORIDE Anon PVC PULL-OUT PLANNED Chem. Week 117 (15): 25 (8 October 1975) Uniroyal Chemical is tentatively phasing out production of its 130-million Ibs/year polyvinyl chloride resin at its Painesville, Ohio, plant. The company states that exceedingly large capital expenditures would be needed to meet OSHA standards and EPA emission rules. Two hundred and fifty workers will be affected by the shutdown. A jointly-owned operation with Borden Chemical will continue to produce vinyl chloride monomer in Louisiana. -167- ------- 31-0030 VINYL CHLORIDE Anon WHAT PPG KNOWS ABOUT VINYL CHLORIDE MONOMER WOULD FILL A BOOK...SO WE DID! Chem. Week 117 (15): 38 (8 October 1975) A new book published by PPG Industries describes their most current procedures for vinyl chloride monomer production, covering properties, hazards, handling, storage, analysis, and other areas. 31-0031 VINYL CHLORIDE McCann, Joyce et al MUTAGENICITY OF CHLOROACETALDEHYDE, A POSSIBLE METABOLIC PRODUCT OF 1,2-DICHLO- ROETHANE (ETHYLENE DICHLORIDE), CHLOROETHANOL (ETHYLENE CHLOROHYDRIN), VINYL CHLORIDE, AND CYCLOPHOSPHAMIDE Proc. Nat. Acad. Sci. USA 7£ (8): 3190-3 (1975) Chloroacetaldehyde, a possible metabolite of vinyl chloride and other industrial chemicals, was shown to be mutagenic in a sensitive bacterial test. Chloro- acetaldehye was, in fact, hundreds of times more mutagenic to one bacterial strain than was vinyl chloride itself, and may be the active carcinogenic form of vinyl chloride. If it is also the active carcinogenic form of dichloroethane and chloroethanol, as well as vinyl chloride, then Chloroacetaldehyde may also cause angiosarcoma in workers exposed to dichloroethane or chloroethanol. -168- ------- 31-0032 VINYL CHLORIDE Anon WHAT CLEAN-AIR RULES WILL COST THE CPI Chem. Week 117 (16): 37 (15 October 1975) The financial impact of clean-air regulations and standards on the chemical industry over the next 15 years is discussed briefly. Capital investments of about $350 million and operating costs of $95 million/year are estimated, on the basis of multiplying an estimated 5,536 stacks by an estimate of the cost of instrumentation for each stack. Additional personnel required for implementing the programs would be a major cost item. The use of a Hewlett-Packard monitor- ing system at Georgia Pacific's vinyl chloride plant at Plaquemine, La., is described as being satisfactory for meeting OSHA's health standards. VINYL CHLORIDE See: 31-0009, Flame Retardants -169- ------- 31-0033 GENERAL INFORMATION Anon EPA BANS ANT POISON FIRM Soap, Cosmet. Chem. Spec. 5± (9): 20 (1975) Life Science Products Co., Hopewell, Va., has been ordered by EPA to cease manu- facture of Kepone, the fire ant poison. Under investigation by EPA and OSHA since the ketone was found in the blood of some employees, the company has now been charged with violation of the law by EPA and faces $16,500 in fines by OSHA. Nine employees are hospitalized with encephalopathy, which is a form of brain damage. If the company follows EPA shipping regulations, it will be allowed to ship existing inventories to its one customer, Allied Chemical's Baltimore plant. Life Science Products Co. is reportedly contesting the federal citations. 31-0034 GENERAL INFORMATION Anon WORKER EXPOSURE TO CHROMATE PIGMENTS CAN LEAD TO "UNUSUALLY" HIGH CANCER RISKS Chem. Eng. News _53_ (41): 8 (13 October 1975) Reporting to NIOSH on the preliminary results of an epidemiological study, the final results of which should be ready by the end of 1975, the Dry Color Manu- facturers' Association states that 29% of the 38 deaths occurring among 580 workers exposed to chromate pigments were caused by lung cancer. In contrast, a 7% lung cancer death rate has been found among lead smelter workers. -170- ------- 31-0035 GENERAL INFORMATION Anon CHROMATE PIGMENTS MAY BE GREATER LUNG-CANCER THREAT'THAN SUSPECTED Chem. Week 117 (16) : 25 (15 October 1975) Working with data submitted by the Dry Color Manufacturers' Association,, NIOSH's Office of Occupational Health Surveillance and Biometrics reports that 85% of all cancer deaths among workers exposed to chromate pigments are from lung cancers, a higher percentage than anticipated. 31-0036 GENERAL INFORMATION Bidleman, T.F. and Olney, C.E. LONG RANGE TRANSPORT OF TOXAPHENE INSECTICIDE IN THE ATMOSPHERE OF THE WESTERN NORTH ATLANTIC Nature 257_ (5526): 475-7 (9 October 1975) Toxaphene, the most widely used U.S. pesticide during the last decade, probably contains about 200 polychlorinated camphenes, although the exact composition of the pesticide is not known. Toxaphene residues may persist in soils for years, but there is some volatilization. Although toxaphene has been found in air samples in just three southern agricultural areas, this report shows that the pesticide has been identified in air samples over Bermuda. Apparently, most of the toxaphene in the air did not originate from Bermuda but was transported through the atmosphere, traveling long distances. -171- ------- 31-0037 GENERAL INFORMATION Porter, John A.H. ACUTE RESPIRATORY DISTRESS FOLLOWING FORMALIN INHALATION (Letter to Editor) Lancet 2_ (7935): 603-4 (27 September 1975) A case of acute pneumonitis in a neurology resident may have been caused by heavy exposure to formaldehyde vapors, arising from the use of formalin, a 40% solution of formaldehyde. 31-0038 GENERAL INFORMATION Hill, Richard N. et al GENETIC CONTROL OF CHLOROFORM TOXICITY IN MICE Science 190 (4210): 159-61 (10 October 1975) Different strains of mice were given chloroform in peanut oil to study its lethal effects. The LD _ dose for the C57BL/6J strain was a 0.33 ml/kg versus 0.08 ml/kg for the DBA/2J strain, indicating that the C57BL/6J strain had about four times the resistance to the lethal effects than the other strain. The kidneys of the DBA/2J animals contained more than twice the amount of chloroform than did those of the more resistant animals. Significant strain differences were noted in chloroform accumulation in first generation offspring, the offspring values being midway between the parental values. -172- ------- REGULATIONS AND STANDARDS See: 31-0018, Fluorocarbons -173- ------- 32-0001 ARSENIC Anderson, A.C. et al THE ACUTE TOXICITY OF MSMA TO BLACK BASS (MICROPTERUS DOLOMIEU), CRAYFISH, (PROCAMBARUA SP.) AND CHANNEL CATFISH (ICTALURUS LACVSTRIS) Bull. Environ. Contain. Toxicol. 14. (3): 330-3 (1975) Because of the possibility that residues of the grass control herbicide, mono- sodium salt methanearsonic acid (MSMA) will build up in waterways near high- ways, when MSMA is used to control Johnson grass, static bioassays were run to determine the acute toxicity of the compound in black bass, crayfish, and channel catfish. Median Lethal Threshold (TLM) determined at 48 hrs were 1660 mg/1, 5100 mg/1, and 4700 mg/1, and at 96 hrs were 900 mg/1, 1100 mg/1, and 3050 mg/1, for black bass, crayfish, and channel catfish, respectively. Thus, even the black bass, the most sensitive of these three species, can tolerate fairly high levels of MSMA. However, the tests did not provide any data on the possible concentration of MSMA by the fish nor indicate changes in toxicity that might be expected under actual environmental stress. No information is available on the toxicity of possible degradation products of MSMA. 32-0002 ARSENIC King, H.G. and Morrow, R.W. DETERMINATION OF ARSENIC AND SELENIUM IN SURFACE WATER BY ATOMIC ABSORPTION TO SUPPORT ENVIRONMENTAL MONITORING PROGRAMS Oak Ridge Y-12 Plant, Tenn. Contract W-7405-eng-26. Report Y-1956 (4 November 1974) A method was developed for determining arsenic and selenium in surface water by atomic absorption. The two elements are hydrided in acidified water by sodium borohydride to form arsine and selenine gases, which are then passed into a low-temperature argon/air/hydrogen flame for the atomic absorption measurement. A background correction is made by adjusting the gas flow rates. The limit of detection is 5 vg/1 for arsenic and 1 yg/1 for selenium. The method is both fast and economical. [Abstract in: Nuclear Sci. Abstracts _31 (3): 803 (15 February 1975) -174- ------- 32-0003 ASBESTOS Anon EVEN IF RESIN IS PLENTIFUL, FILLERS WILL PLAY A BIG ROLE Mod. Plast. 52_ (10): 59-61 (1975) In the plastics area one result of materials shortages is the increasing use of fillers. It is estimated that the 1.06 million tons of fillers consumed in 1975 will increase to 2.5 million by 1980, to 6.9 million by 1990, and to 15 million tons by 2000. Fillers of the future are expected to provide plastics with new performance characteristics in addition to serving as extenders, an added value seen possible from the advent of coupling agents and micropacking. Because of the new dust-free pellets developed by Union Carbide, asbestos is expected to show great gains in the filler market. The 180,000 tons of asbestos that may be used for this purpose in 1975 is estimated to grow to 800,000 tons by 1980 and 1.7 million tons by the year 2000. 32-0004 ASBESTOS Hefner, Robert E., Jr. and Gehring, Perry J. A COMPARISON OF THE RELATIVE RATES OF HEMOLYSIS INDUCED BY VARIOUS FIBROGENIC AND NON-FIBROGENIC PARTICLES WITH WASHED RAT ERYTHROCYTES IN VITRO Am. Ind. Hyg. Assoc., J. _36 (10): 734-40 (1975) Confirmation of an existing relationship between fibrogenicity and hemolytic activity for various particulates is reported from these in vitro tests with rat erythrocytes, using Min-U-Sil Filler Silica, Hooker #1 Chrysotile Asbestos, and nine other materials. A significant hemolysis of erythrocytes, following apparent first order kinetics, was produced by the silica of a 5 v number length mean diameter. Asbestos of the same number length mean diameter produced a comparable or even greater rate of hemolysis. -175- ------- 32-0005 ASBESTOS Anon BACKGROUND INFORMATION ON NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS - PROPOSED AMENDMENTS TO STANDARDS FOR ASBESTOS AND MERCURY EPA, Research Triangle Park, N.C., Office of Air Quality Planning and Standards, EPA-450/2-74-009a (Oct. 1974). PB-237 169/8GA Rationale for amendments promulgated April 6, 1973, and an evaluation of their economic and environmental impacts are presented. Report covers asbestos pollution related to manufacturing, demolition and renovation, fabrication and disposal of wastes and mercury emissions from sludge incineration and drying facilities. Optional air cleaning methods for compliance with asbestos standards, chemical stabilization of waste disposal sites, and estimation of allowable mercury emissions from sewage sludge incineration facilities are discussed. [Abstract in: Government Reports Announcements _75_ (1): 109 (]_o January 1975)] 32-0006 ASBESTOS Carton, Robert J. DEVELOPMENT DOCUMENT FOR EFFLUENT LIMITATIONS GUIDELINES AND NEW SOURCE PERFORMANCE STANDARDS FOR THE BUILDING, CONSTRUCTION, AND PAPER SEGMENT OF THE ASBESTOS MANUFACTURING POINT SOURCE CATEGORY EPA, Wash., D.C., Effluent Guidelines Div. EPA/440/l-74-017a (February 1974) PB-238 320/6GA This document presents the findings of an extensive study of a segment of the asbestos manufacturing industry for the purpose of developing effluent limitations guidelines and Federal standards of performance for the industry. The development of data and recommendations in the document relate to a portion of the asbestos manufacturing category which contains the major water users in this industry. Subcategories include asbestos-cement pipe, asbestos-cement sheet, asbestos paper (with starch and elastomeric binders), asbestos mill- board, asbestos roofing products, and asbestos tile. Manufacturing processes, wastes, control technologies, and costs are discussed. [Abstract in: Government Reports Announcements 75 (7); 116 (4 April 1975)J -176- ------- ASBESTOS See also: 32-0036, General Information -177- ------- 32-0007 BENZIDINE Pliss, Gennady B. and Khudoley, V.V. TUMOR INDUCTION BY CARCINOGENIC AGENTS IN AQUARIUM FISH J. Nat. Cancer Inst. ,55 (1): 129-36 (July 1975) Guppies and zebra fish were exposed (via feeding, skin application, ip injections, and other methods) to nine chemicals known to be carcinogenic to man. Although five of these chemicals, including two nitrosamines, produced liver tumors in some of the fish, benzidine and three other chemicals did not induce any tumors. Benzidine is converted biochemically in the liver but it is not significantly hepatotropic. The experiment indicates that fish are suitable models for testing the carcinogenic activity of chemicals and for the measurement of water pollution. -178- ------- 32-0008 HEXACHLOROBENZENE Crist, Howard L. et al RAPID DETERMINATION AND CONFIRMATION OF LOW LEVELS OF HEXACHLOROBENZENE IN ADIPOSE TISSUES Bull. Environ. Contain. Toxicol. 14. (3): 273-81 (1975) A rapid, simple, but sensitive and reliable method is .described for the detection and confirmation of HCB in lipid material at levels as low as 5ppb. Hexane and a Florisil column were used to separate HCB from the coextractives in chicken fat. A Tracor, MT-220 gas chromatograph with a tritium electron capture detector was used. 32-0009 HEXACHLOROBENZENE Villeneuve, D.C. and Newsome, W.H. TOXICITY AND TISSUE LEVELS IN THE RAT AND GUINEA PIG FOLLOWING ACUTE HEXACHLOROBENZENE ADMINISTRATION Bull. Environ. Contain. Toxicol. 14 (3): 297-300 (1975) Rats and guinea pigs were dosed daily (p.o.) with HCB in corn oil for 16 days at 500 mg/kg body weight. All the guinea pigs (7 each, male and female) died during dosing. Eight of 11 male rats, and 5 of 11 female rats died also. Analysis of residue levels in brain and liver tissues showed a much greater accumulation, however, in the rats than in the guinea pigs. Rats also showed a lower body weight loss. -179- ------- 32-0010 HEXACHLOROBENZENE Morita, M. and Oishi, S. CLEARANCE AND TISSUE DISTRIBUTION OF HEXACHLOROBENZENE IN RATS Bull. Environ. Contain. Toxicol. _U (3): 313-8 (1975) In this 56-day study of the distribution and clearance rate of HCB in rats, HCB was concentrated mainly in the fat and to a lesser degree in the brain, heart, lungs, liver, kidneys, and testes. Fat content was 18.76 ± 1.54 vg/g (on wet basis) compared to testes content of 0.21 ± 0.05 yg/g. In most organs, maximum concentration was reached within 6 or 12 hours, decreasing rapidly thereafter. -180- ------- 32-0011 HYDRAZINE Germaise, Annie B-K. et al IMMUNOLOGIC ASPECTS OF 1,2-DIMETHYLHYDRAZINE-INDUCED COLON TUMORS IN RATS J. Nat. Cancer Inst. 54 (5): 1231-5 (1975) 1,2-Dimethylhydrazine (DMH) is known to produce colon tumors in the rat. Two experiments were conducted to determine if DMH-induced tumors contain specific antigens or if there is a histological difference in cellular response, when rats are fed a lipotrope-deficient diet instead of an adequate diet. In one experiment 12-week old rats received intragastrically 10 doses of 30 ml/kg/wk of DMH dissolved in 0.9% NaCl or 1 ml/week of NaCl. In another experiment, 7-week old rats, fed diet 1 or 2, received intragastrically 30 mg/kg/wk of DMH, for 5 or 10 doses. Results indicated that an antigen in an extract of colon tumors, not found in normal colon, was related to antigens in rat fetuses. No immunological cross- reactions with carcinoembryonic antigen were noted. There was a significant spatial relationship between mucinous adenocarcinomas of the colon and lymphoid follicles. -181- ------- 32-0012 ISOCYANATES Anon NEW CONTENDER FOR PLASTICS PARTS MARKETS Chem. Week 117. (15): 40 (8 October 1975) The isocyanate used in Dow's new Instant Set Polymer (See: CATS 30-0021) has not been identified by the company but, according to U.S. Patent 3,726,827 (1973), it is derived from reacting a diisocyanate, e.g., toluene diisocyanate, with a smaller amount of polyol. Polyol preparation and related process steps are described briefly. Dow has issued two licenses for its ISP, a rigid urethane engineering plastic, to Micromet in Houston and to Jones & Vining in Salem, Mass., and anticipates that ISP will find a big market as a replacement for metals, ceramics, and wood. 32-0013 ISOCYANATES (Market) Anon UPJOHN SEES BIG MARKET FOR URETHANE IN MIDEAST Chem. Week UJ (17):63 (22 October 1975) According to Keith Edmondson, Upjohn Chemical Division, consumption of urethane in the Mideast and Africa will increase by 20-22%/year through 1984, rising from the current 750,000 metric tons to 1.78 million metric tons in 1984. For the same period, the worldwide increase in urethane consumption is estimated at 12-14%/year; current worldwide consumption of 680,000 metric tons of isocy- anates should reach 1.7 million metric tons by 1984. -182- ------- 32-0014 ISOCYANATES (Production) Anon THREE HUNDRED MILLION LBS. Chem. Eng. News 53_ (43): 12 (27 October 1975) In an advertisement, Upjohn Polymer Chemicals reports that its constantly expanding La Porte, Texas, facility and its European and Japanese facilities now provide the company with an annual capacity of 300 million Ibs of isocy- anates, useful for a variety of urethane products. -183- ------- 32-0015 LIQUEFACTION AND GASIFICATION OF COAL Anon AND NEXT WEEK ERDA WILL DEDICATE A PILOT PLANT TO CONVERT COAL. . . Chem. Eng. News 53 (43): 18 (27 October 1975) C.E. Lummus Co. will operate the $15 million Bruceton, Pa. pilot plant in which 72 tons/day of sulfur-rich Appalachian coal or western coal will be converted by Bu Mines Synthane process to raw synthesis gas. The gas, in turn, will be cleaned and methanated to yield 1.2 million cu ft of pipeline-quality methane. LIQUEFACTION AND GASIFICATION OF COAL See also: 32-0037, General Information -184- ------- 32-0016 NITRILOTRIACETIC ACID Shannon, Earl E. EFFECTS OF DETERGENT FORMULATION ON WASTEWATER CHARACTERISTICS AND TREATMENT J. Water Pollut. Control Fed. ^7 (10): 2371-83 (1975) As part of continuing studies on the effects of detergent builders on domestic wastewater characteristics and wastewater treatment processes, the Wastewater Technology Centre of the Environmental Protection Service, Burlington, Ont., Canada, replaced all laundry detergents with nitrilotriacetic acid (NTA), carbonate, phosphate-, and citrate-based products. NTA substitutions reduced total phosphorus loadings below baseline by 25.8%; carbonate substitutions reduced them by 22-3%. NTA degradation during the study was 60 to 75%; citrate degradation was more than 95%. The NTA-mercury, -cadmium, and -nickel complexes showed poor degradability when applied to the laboratory activated sludge system. -185- ------- 32-0017 POLYURETHANES Anon FAKE LEATHER IS A REAL SUCCESS Chem. Week 117 (17): 59-60 (22 October 1975) Aerfab, Huntington Station, New York, a small ($2-3 million in sales for 1975) manufacturer of urethane-coated fabrics (simulated leather and suede fabrics) uses an undisclosed method of coating urethane onto a variety of backing fabrics, The company has successfully stayed in a business that many major manufacturers had to give up. The breathability and finished-product stability of urethanes apparently make them superior to vinyls and they may be substituted eventually for vinyl fabrics in autos. Other advantages of urethane fabrics include: no plasticizer migration, more resistance to abrasion, better washable and dry- cleanable results. Current main uses are clothing and homefurnishings. POLYURETHANES See: 32-0012, Isocyanates 32-0013, Isocyanates 32-0014, Isocyanates -186- ------- 32-0018 TRICHLOROETHYLENE Anon OSHA PLANS RULES FOR TWO MORE CHEMICALS Chem. Eng. News _53 (42) : 7 (20 October 1975) Proposed new OSHA occupational exposure standards for beryllium and trichloro- ethylene were prompted by animal studies that indicated the potential carcino- genicity of the chemicals. At this time, however, OSHA's preliminary data on trichloroethylene are not such that OSHA can tag the solvent with the capability of causing cancer in humans, but inhalation tests showed that beryllium induced lung tumors in rats and lung cancers in monkeys. Also, beryllium given intra- venously to rabbits caused bone tumors. OSHA, therefore, has labeled beryllium as a potential human carcinogen. -187- ------- 32-0019 VINYL CHLORIDE Brand, K. Gerhard et al BRIEF COMMUNICATION: FOREIGN-BODY TUMORIGENESIS BY VINYL CHLORIDE VINYL ACETATE COPOLYMER: NO EVIDENCE FOR CHEMICAL COCARCINOGENESIS J. Nat. Cancer Inst. 5£_(5) : 1259-62 (1975) In this study the tumors caused in mice by implants of vinyl chloride vinyl acetate copolymer (VGA) were attributed to the presence of a foreign body only. There was no evidence of a cocarcinogenic effect from the vinyl chloride monomer. 32-0020 VINYL CHLORIDE Spirtas, Robert et al THE ASSOCIATION OF VINYL CHLORIDE EXPOSURES WITH MORBIDITY SYMPTOMS Am. Ind. Hyg. Assoc. , J. _36_ (10): 779-89 (1975) The results of a 1974 mail questionnaire survey of VC polymerization workers are reviewed. The survey sought information on the frequency of eight symptoms, four of which were related to central nervous system disturbances; two to peripheral neurovascular and neuromuscular disturbances; one to local irritation of eyes, nose, throat; and one to generalized asthenia, or "run-down" feeling. In summary, the results show a clear VC dose-response relationship for dizzyness, nausea, headache, "pins and needles" in arms and legs, and general "run-down" feeling. The dose-response pattern was not statistically significant for passing out, or for local irritation of eyes, nose, or throat. Muscle weakness did not exhibit a dose-response relationship. -188- ------- 32-0021 VINYL CHLORIDE (Production) Anon VINYL CHLORIDE Chem. Eng. News .53 (43) : 11 (27 October 1975) Diamond Shamrock is contemplating building a plant for the production of vinyl chloride monomer, which it uses (but does not now make) to produce polyvinyl chloride. 32-0022 VINYL CHLORIDE Carpenter, Ben H. VINYL CHLORIDE. AN ASSESSMENT OF EMISSIONS CONTROL TECHNIQUES AND COSTS Research Triangle Inst., Durham, N.C. Contract EPA-68-02-1325. Final Rep. June-August 1974 (September 1974). EPA/650/2-74-097. PB-237 343/9GA The report gives results of a survey of conceptual techniques applicable to vinyl chloride monomer (VCM) emission reduction with respect to VC monomer and polymer production. VCM emission points have been identified and quantified for four types of monomer plants—hydrochlorination of acetylene, chlorination/ oxychlorination of ethylene (with oxygen) and dehydrochlorination, and direct chlorination of ethylene and dehydrochlorination—and four types of polymer manufacture—suspension polymerization, emulsion polymerization, bulk poly- merization, and solution polymerization. Levels of control acievable and estimated cost of listed control techniques are presented. [Abstract in: Government Reports Announcements 75 (1): 50 (10 January 1975)] -189- ------- 32-0023 VINYL CHLORIDE Cox, R.A. et al PHOTOCHEMICAL REACTIVITY OF VINYL CHLORIDE UKAEA Res. Group, Harwell. Atomic Energy Res. Establishment. AERE-R-7820. September 1974 (Available from NTIS) The reactivity of vinyl chloride in the photochemical smog system was measured by two methods. In the first its reactivity has been compared with that of ethylene, propylene, and trans-2-butene when irradiated in air with simulated sunlight in the presence of nitric oxide. In the second its rate of reaction with hydroxyl radicals has been measured using OH produced by photolysis of nitrous acid. Vinyl chloride is only moderately reactive being similar to or slightly less reactive than ethylene but more reactive than normal paraffins. [Abstract in: Nuclear Sci. Abstracts 31 (3): 805 (15 February 1975)] 32-0024 VINYL CHLORIDE Anon A SINGLE POLYVINYL-CHLORIDE PLANT. . . Wall Street Journal, Wednesday (29 October 1975) p.1 Nine deaths from angiosarcoma have occurred among workers in a PVC plant in Shawinigan, Quebec. The plant, owned by a B.F. Goodrich Co. subsidiary, reportedly has taken steps to reduce employee exposure to vinyl chloride. -190- ------- 32-0025 VINYL CHLORIDE Anon HANDLING PVC POWDERS SAFELY European Plastics News 2 (9): 4 (1975) Recent studies indicate that fine PVC dust can lower the lower explosive limit of vinyl chloride/air mixtures thus raising the possibility of explosions when the contents of polymer tankers are being transferred to silos. It is recommended that tankers, hoses, and bulk storage systems be earthed. Potentially ignitable levels of vinyl chloride monomer may also occur during the operation of high speed mixing equipment. Safe operating procedures are outlined in "Vinyl Chloride Monomer: Guide to the High Speed Mixing of PVC Resins and Compounds," a booklet published by the British Plastics Federa- tion and the Chemical Industries Association. 32-0026 VINYL CHLORIDE Haley, Thomas J. VINYL CHLORIDE: HOW MANY UNKNOWN PROBLEMS? J. Toxicol. Environ. Health .1 (1): 47-73 (1975) This comprehensive review of the literature on vinyl chloride covers its synthesis and physical properties, analysis, biotransformation; discusses industrial hygiene aspects, the use and effects of aerosols; reviews animal and human toxicology, and animal and human carcinogenesis. Although VC induces cancer in man, the conditions for this induction are not yet related to ambient exposure levels. It is recommended that epidemiological surveys be continued in an effort to determine the latent period of exposure and degree of exposure required for angiosarcoma development; that animal experiments be undertaken on the effects of short exposures at high concentra- tions and long exposures at low concentrations; and that more rapid diagnostic and therapeutic measures be sought. -191- ------- 32-0027 GENERAL INFORMATION Exon, J.H. and Roller, L.D. EFFECTS OF FEEDING MANGANESE ANTIKNOCK GASOLINE ADDITIVE EXHAUST RESIDUES (Mn304) IN RATS Bull. Environ. Contain. Toxlcol. 14 (3): 370-3 (1975) To determine the toxicity of methylcyclopentadienyl manganese trlcarbonyl (MMT), rats were fed diets containing varying amounts of hausmanite (manganous manganic oxide) (Mn304), the major residue produced when MMT is heated as it would be when it is used as an antiknock additive in unleaded gasoline. Concentrations in the feed ranging from 200 to 200,000 ppm proved to be only slightly toxic to the rats. Growth rates indicated no clinical signs of manganese toxicity, and no gross pathological changes were noted at necropsy. No significant lesions were noted in the the histopathological examination of selected organs and tissues. It is concluded that Mn304 need not be extensively investigated as an acutely hazardous environmental contaminant. 32-0028 GENERAL INFORMATION Ottolenghi, A.D. et al . INHALATION STUDIES OF NICKEL SULFIDE IN PULMONARY CARCINOGENESIS OF RATS J. Nat. Cancer Inst. 54_(5): 1165-72 (1975) Lung tumors developed in twenty-nine (14%) of the 208 rats (those in an examinable condition from a total of 226 at the start of the test) that inhaled nickel sulfide for 78 weeks (5 days/wk, 6 hr/day). In contrast, lung tumors were found in only 1% of the controls. Rats subjected to the nickel sulfide also showed a higher incidence of pulmonary inflammatory reactions. Although there was no significant difference in the deaths of animals during the first year, there were significant differences during the last 26 weeks. Less than 5% of the rats exposed to nickel sulfide survived until the end of the study; 31% of the controls survived. Half of the treated rats were injected with hexachlorotetrafluorobutane, an agent that induces lung infarction. This agent neither increased the proportion of animals having lesions nor did it change the type of lesions in animals exposed to nickel sulfide. -192- ------- 32-0029 GENERAL INFORMATION Ott, M. Gerald et al LINKING INDUSTRIAL HYGIENE AND HEALTH RECORDS Am. Ind. Hyg. Assoc., J. J36 (10): 760-6 (1975) Described here are the procedures developed by Dow Chemical Company to correlate data on employee exposure to hazardous chemicals with employee medical history, using the personnel record card as an essential link in the system. Dow initiated a company industrial hygiene program in the late 1930*s. 32-0030 GENERAL INFORMATION Anon MANGANESE POISONING REPORTED... Am. Ind. Hyg. Assoc., J. _36 (10): A-14 (1975) A California foundry worker exposed to fumes from cutting and burning manganese steel developed manganese poisoning. A second such poisoning, also reported in California, was caused by manganese dioxide dusts used in glazing ceramics. Characterized by severe, persistent chronic depressive psychosis, transient acute brain syndrome, and various extrapyramidal symptoms, Mn poisoning is difficult to diagnose. Its symptoms usually do not occur until after several years of exposure. -193- ------- 32-0031 GENERAL INFORMATION Anon RUBBER WORKERS SUE... Am. Ind. Hyg. Assoc. , J. 36_ (10): A-14 (1975) Union workers reputedly injured by spills of phosgene and other toxic chemicals are suing Olin Corp. and General Tire & Rubber Co. for $2.5 million. Claiming that Olin has been discharging phosgene for years, the workers earlier had requested help from state and federal environmental agencies. Phosgene is not currently covered by any EPA standard. 32-0032 GENERAL INFORMATION Anon MICROWAVE HAZARDS Lancet 2 (7937): 694 (11 October 1975) Microwave radiation, which has been used as a source of heat in diathermy and more recently in cooking ovens, may be a long-term hazard to man's nervous and reproductive systems. From Bucharest comes a report [I. Lancranian et al, Health Physics 29; 431 (1975)] of a loss of libido and interference with sperma- togenesis in technicians exposed to microwave radiation for several years. -194- ------- 32-0033 GENERAL INFORMATION Zapp, J.A., Jr. HMPA: A POSSIBLE CARCINOGEN (Letter to Editor) Science 190 (4213): 422 (31 October 1975) In a long-term inhalation study conducted by du Pont, rats were exposed to from 0 to 4000 ppb (by volume) of hexamethylphosphoramide (HMPA) for 6 hrs/day, 5 days/wk. Although no compound lesions occurred during the first six months, degenerative changes in the convoluted tubes of the kidneys caused deaths between months 6 and 8. In the 8th month, squamous cell carcinomas developed in the nasal cavities of some rats and penetrated into their brains. The incidence of tumors was dose-related. HMPA is used as a laboratory solvent and as a chemosterilant for insect pests. It has been shown to be mutagenic to some insects and to interfere with sperma- togenesis in rats. 32-0034 GENERAL INFORMATION Posner, Herbert S. BIOHAZAKDS OF METHANOL IN PROPOSED NEW USES J. Toxicol. Environ. Health _! (1): 153-71 (1975) Numerous cases of poisoning from the ingestion or inhalation of methanol are reviewed along with the symptoms of delayed and irreversible toxicity. Among the unanswered questions about methanol is its potential effect on youngsters exposed to it. The review is timely because of the many new, large-scale uses now suggested for methanol — as a source of energy, as a bacterial feedstock for feed protein, in waste water denitrification — which open the way for potential environmental hazards. It is recommended that a safer compound be used, when possible. -195- ------- 32-0035 GENERAL INFORMATION Hoel, David G. et al ESTIMATION OF RISKS OF IRREVERSIBLE, DELAYED TOXICITY J. Toxicol. Environ. Health 1 (1): 133-151 (1975) Four sequential steps to follow in translating animal test results to human hazard risk are discussed in this review of the statistical methods now used and of current knowledge on the subject. Additional research is needed to improve the quality of models involving time-to-response techniques; more must be learned about man's heterogeneous nature and susceptible subgroups of humans. 32-0036 GENERAL INFORMATION Berg, John W. and Howell, Margaret A. OCCUPATION AND BOWEL CANCER J. Toxicol. Environ. Health .1 (1): 75-89 (1975) This review of U.S. and British mortalities from colonic and rectal cancers is linked with a broad group of occupations. A high risk for large-bowel cancer is associated with white-collar workers and with those in such manufacturing industries as metal work, textiles, and leather goods. There is some less conclusive correlations with workers exposed to dyes, meat handling, smoke inhalation, and chemicals. An earlier study indicated that bowel cancer risks might be associated with asbestos workers. -196- ------- 32-0037 GENERAL INFORMATION Anon SCIENTIST CLAIMS NEW PROCESS FOR PRODUCING ELECTRICITY FROM COAL Coal Age 80 (11): 298 (1975) A non-polluting electrochemical process for producing electricity from low-grade coal or from the char that remains when oil is produced from coal was announced at a recent Energy Conversion Engineering Conference by Dr. Michael Ambar of Stanford Research Institute. The char is heated in a molten carbonate medium at 600-800°C without releasing sulfur oxides, nitrogen oxides, and particulates into the atmosphere. Cost data have not been calculated; some engineering problems remain to be solved. -197- ------- 33-0001 ACRYLONITRILE Taninaka, Takuml and Minoura, Yuji KINETIC STUDY OF RADICAL POLYMERIZATION OF ACRYLONITRILE IN THE PRESENCE OF TRIPHENYL PHOSPHITE J. Polym. Sci. (Polym. Chem. Ed.) L3_ (10): 2335-44 (1975) In this investigation of the radical polymerization of acrylonitrile in the presence of triphenyl phosphite with a,a'-azobisisobutyronitrile (AIBN) initiation, the authors studied the reaction kinetics and derived equations for the rate and degree of polymerization 33-0002 ACRYLONITRILE Taninka, Takumi et al PHOTOPOLYMERIZATION OF ACRYLONITRILE IN THE PRESENCE OF SUBSTITUTED TRIPHENYL PHOSPHITES J. Polym. Sci. (Polym. Chem. Ed.) .13 (10): 2353-62 (1975) The photopolymerization of acrylonitrile under the influence of triphenyl phosphite (TPP) derivatives is reported. Although acrylonitrile alone did not polymerize, in the presence of TPP and its derivatives acrylonitrile polymerized at 30°C by ultraviolet radiation. -198- ------- 33-0003 ARSENIC Anon POLLUTION RULES MAY FORCE ASARCO TO SHUT SMELTER Chem. Week 117 (18): 11 (29 October 1975) Unless the Washington State Pollution Control Board rescinds an earlier decision of the Puget Sound Air Pollution Control Agency, Asarco Inc. claims that it will have to cease operations at its Tacoma, Wash., smelter. Asarco sees $20 million needed to add arsenic emissions pollution control facilities and an additional $200,000/yr in plant operating costs to meet OSHA's proposed 4-micron standard for worker exposure within the smelter. 33-0004 ARSENIC Anon ASARCO LOSES ANOTHER ROUND IN TACOMA POLLUTION BATTLE Chem. Week 117 (20)_: 9 (12 November 1975) The Washington State Pollution Control Board denied Asarco Inc.'s appeal to reverse the Puget Sound Air Pollution Control Agency's decision not to grant an arsenic emissions standards variance for Arsaco's Tacoma smelter. The Board found insufficient proof that the smelter's emissions are not a health hazard. In April 1976, the pollution agency will seek an injunction against Asarco's continuing to operate the smelter. -199- ------- 33-0005 ARSENIC Talmi, Yair and Bostick, D.T. DETERMINATION OF ALKYLARSENIC ACIDS IN PESTICIDE AND ENVIRONMENTAL SAMPLES BY GAS CHROMATOGRAPHY WITH A MICROWAVE EMISSION SPECTROMETRIC DETECTION SYSTEM Anal. Chem. 47 (13): 2145-50 (November 1975) The presence of arsenic acids as major, minor, or trace components in pesticides and in environmental samples can be detected by the use of a gas chromatograph with a microwave spectrometric detector. Relative sensitivity for water samples is claimed to be at least 0.25 yg/1. 33-0006 ARSENIC Klemmer, H.W. et al ARSENIC CONTENT OF HOUSE DUSTS IN HAWAII Bull. Environ. Contain. Toxicol. 14_ (4): 449-52 (October 1975) Thirty-two homes in Hawaii where pesticides were used for termite control had higher levels of arsenic in the house dust than were found in 29 untreated homes. One exception, where dust samples from untreated home had exceptionally high arsenic content in the dust, were the homes of employees of pest control or wood treatment firms. -200- ------- 33-0007 ASBESTOS Anon THE NAVY HAS REFUSED TO SEEK OUT. . . Environment 17 (8): 23 (November 1975) During WW II some 3 million shipyard workers were exposed to asbestos used to insulate pipes and valves. Many of these may be suffering from lung cancer or mesothelioma as a result of inhaling the asbestos. Although the Navy will pay workmen's compensation to those afflicted, it is not willing to seek out the shipyard workers who may have been exposed. Current ship- building techniques have apparently eliminated this problem. -201- ------- BENZIDINE See also: 33-0008, 3.3'-Dichlorobenzidine -202- ------- 33-0008 3,3'-DICHLOROBENZIDINE Gadian, Theodore CARCINOGENS IN INDUSTRY, WITH SPECIAL REFERENCE TO DICHLOROBENZIDINE Chem. Ind. 19_: 821-31 (4 October 1975) Although 3,3'-dichlorobenzidine (DCB) .because of the similarity of its chemical structure to that of benzidine, a known carcinogen, and because it is carcinogenic to animals ,has been suspected as a human urinary tract carcinogen, the lack of a proper test population (those exposed only to DCB) has prevented the collection of significant statistics. Data have now been collected on 59 British DCB workers and the results show that none of them developed tumors, although workers exposed to mixed benzidine and DCB developed bladder cancers. It is concluded that DCB may not be a human carcinogen (unless the latent period is longer than 18 years) or that, if it is carcinogenic to man, it is a weaker one than benzidine. -203- ------- 33-0009 FLAME RETARDANTS Anon TRIMETHYL PHOSPHITE Chem. Eng. News .53 (44): 12 (3 November 1975) Mobil Chemical expects to go onstream in early 1977 with its multi-million dollar second unit of a trimethyl phosphite plant in Charleston, S.C. The product is used in the manufacture of flame retardants and nonperoistent crop chemicals. Mobil is not divulging plant capacity. -204- ------- 33-0010 FLUOROCARBONS Anon MORE EVIDENCE ADDS TO OZONE CONTROVERSY Chem. Eng. News 53_ (44): 8 (3 November 1975) Researchers at the National Bureau of Standards report that at 25°C they found the rate of reaction between chlorine and ozone to be only 60% of the value used by Rowland et al to predict stratospheric ozone depletion, and at -50°C NBS reports the reaction rate is only 44% of Rowland's value. Rowland argues that such changes in the reaction rate would not change the ozone depletion measurements. 33-0011 FLUOROCARBONS Anon NEW TECHNIQUE BOOSTS C0?'s PROPELLANT PROSPECTS Chem. Week 117 (19): 55 (5 November 1975) Adding impetus to the use of carbon dioxide as a replacement for fluorocarbon propellants is a newly announced system for packaging aerosol fragrances in glass containers. It involves a CO- valve made by Risdon Manufacturing of Naugatuck, Conn., and a high-pressure plastic-coated glass bottle by Wheaton Corp's Plasti-Cote Division in Mays Landing, N.J. The new valve permits Co2 to deliver a spray pattern that remains consistent for the life of the package. -205- ------- 33-0012 FLUOROCARBONS Barton, I.J. and Robertson, D.F. MEASUREMENTS OF ERYTHEMALLY EFFECTIVE ULTRAVIOLET RADIATION AND TOTAL OZONE CONTENT Nature 258 (5530): 68-9 (6 November 1975) In separate studies in Australia and the U.S. measurements are being made of erythemally effective ultraviolet radiation - wavelengths between 290 and 320 nm. The resulting information shows the change in UV irradiance resulting from a change in total ozone content. The long-term monitoring is considered important because of the current ozone controversy. -206- ------- 33-0013 HEXACHLOROBENZENE Grant, D.L. et al CHEMICALt(HCB) PORPHYRIA: EFFECT OF REMOVAL OF SEX ORGANS IN THE RAT Bull. Environ. Contain. Toxicol. 14_ (4): 422-5 (October 1975) HCB was fed ad libitum to male and female weanling rats in dietary levels of 100 and 500 ppm (equivalent to 5 and 25 mg/kg). Females showed higher levels of hepatic porphyrins than males. An increase of porphyrins was found in the liver of rats given the 100 ppm diet, after the testes were removed; on the same diet, females whose ovaries were removed showed a decreased level of porphyrins in the liver. The higher-level HCB diet apparently masked this effect, but it appears that the mechanism of porphyria induction in rats depends upon the steroids produced by the testes and ovaries. -207- ------- 33-0014 ISOCYANATES (Market) Anon TDI PRODUCERS ACT TO NARROW DISCOUNTS Chem. Week 117 (20): 45 (12 November 1975) Price of toluene diisocyanate seems to be moving up to the 45/lb mark. As of 15 Nov., Olin's price for TDI will be 40.8/lb; other manufacturers are planning to ask about 40/lb, a 5«?/lb discount from list. -208- ------- 33-0015 LIQUEFACTION AND GASIFICATION OF COAL Anon RILEY STOKER WILL MARKET COAL GASIFICATION UNITS Chem. WeekJLl? (19): 55 (5 November 1975) Riley Stoker's Riley division, Worcester, Mass., is offering a standard-size coal gasification unit that uses a fixed-bed, low-pressure, partial-oxidation process that will cost users $1.60 to $2.20/million Btus. Cost variation depends on type of coal burned. The gasifier has 10.5-ft diameter, and burns 3.5 tons coal/hr to give gas with a heating value of 125-150 or 250-300 Btus. The lower value is the result of air blowing; the higher, oxygen blowing. 33-0016 LIQUEFACTION AND GASIFICATION OF COAL Beychok, Milton R. ENVIRONMENTAL FACTORS IN PRODUCING SUPPLEMENTAL FUELS Hydrocarbon Process. 54 (10): 78-81 (1975) The results of an EPA-sponsored study on the process technology and environ- mental factors involved in producing 1) SNG from coal, crude oil, and naphtha; 2) liquid fuels from oil shale; 3) clean fuels from coal liquefaction; and in 4) importing gas supplies as LNG and methanol; or 5) regasifying imported LNG are summarized. Comparative data are shown for thermal efficiency, 802 emissions, No emissions, water intake, effluent discharge, and attainable property line noise level. As an example, the results, presented on the basis of tons emitted per unit of product Btu output, shows the naphtha SNG plant to have the lowest S02 emissions, The author suggests a more meaningful measurement would result, if measurement were based on the percentage of input sulfur released to the atmosphere. The full EPA report contains information on additional environmental factors. -209- ------- 33-0017 MODEL ECOSYSTEMS Anon ECOSYSTEM PRODUCTIVITY Environ. Rep. £ (12): 96 (31 October 1975) National Academy of Sciences is offering at $11.50, "Productivity of World Ecosystems", the proceedings of a symposium covering productivity of oceans, fresh water, grassland, desert, temperate forests, and tundra. 33-0018 MODEL ECOSYSTEMS Anon SLUDGE/CROP CONTAMINATION Environ. Rep. £ (12): 93 (31 October 1975) The human food chain may be irreversibly contaminated from cadmium-containing sewage sludge, according to D.E. Baker, College of Agriculture, Agricultural Experiment Station, Pennsylvania State University. His studies show that the leaves and grain of corn and soybean crops retain large amounts of cadmium applied in tests. Cadmium and other trace elements, therefore, should be removed from sewage sludge that will be used as a fertilizer. -210- ------- 33-0019 OPTICAL BRIGHTENERS Pope, Martin INDUSTRIAL APPLICATIONS OF PHOTOCHEMISTRY Pure Appl. Chem. 41 (4): 535-58 (1975) This review of the most important technical applications of photochemistry includes a section on luminescence in which optical brighteners are described. The rigid, flat molecular structure of optical brighteners (used in detergents, paper, textiles, etc.) favors high fluorescence yields. -211- ------- 33-0020 PERCHLOROETHYLENE Bonse, G. et al CHEMICAL REACTIVITY, METABOLIC OXIRANE FORMATION AND BIOLOGICAL REACTIVITY OF CHLORINATED ETHYLENES IN THE ISOLATED PERFUSED RAT LIVER PREPARATION Biochem. Pharmacol. 24^ (19): 1829-34 (1 October 1975) The uptake, solubility in liver tissue, metabolites, and enzyme activities of tetrachloroethylene, trichloroethylene, and dichloroethylenes in rats was studied in relation to the acute liver toxicity of these compounds, 33-0021 PERCHLOROETHYLENE Nicholson, A. Arnold and Meresz Otto ANALYSIS OF VOLATILE,. HALOGENATED ORGANICS IN WATER BY DIRECT AQUEOUS INJECTION-GAS CHROMATOGRAPHY Bull. Environ. Contain. Toxicol. 14_ (4): 453-6 (October 1975) Direct aqueous injection-gas chromatography with an EC detector was used to determine the volatile, halogenated compounds present in Ontario drinking water. The method was considered fast, sensitive, and accurate. A table lists the detection limits for some of the halogenated compounds found. For tetrachloro- ethylene, the detection limit was 8 yg/1. -212- ------- 33-0022 PHTHALATES Giam, C.S. et al RAPID AND INEXPENSIVE METHOD FOR DETECTION OF POLYCHLORINATED BIPHENYLS AND PHTHALATES IN AIR Anal. Chem. _47 (13): 2319-20 (November 1975) The electro-capture gas chromatograph, using Florosil to trap the tested compounds, proved to be a simple, inexpensive, and sensitive method for detecting low levels of certain phthalate esters, PCBS and DDT in the air. DEHP was one of the test compounds. Phthalic acid esters are produced in amounts about 10 times greater than PCBS by industry. 33-0023 PHTHALATES Giam, C. S. et al SENSITIVE METHOD FOR DETERMINATION OF PHTHALATE ESTER PLASTICIZERS IN OPEN- OCEAN BIOTA SAMPLES Anal. Chem. 47^ (13): 2225-9 (November 1975) Gas chromatography with an electron capture detector successfully detected background levels as low as 25 ng of dibutyl phthalate and 50 ng of di-2- ehtylhexyl phthalate (DEHP) (in the presence of chlorinated hydrocarbons) in marine biota samples. About 1 billion Ib/yr of phthalate plasticizers, which are widely dispersed in the environment and may be toxic to aquatic organisms, are manufactured. -213- ------- 33-0024 TRICHLOROETHYLENE Department of Labor, OSHA TRICHLOROETHYLENE. PROPOSED OCCUPATIONAL EXPOSURE STANDARD Fed. Regist. _40 (203) : 49031-45 (20 October 1975) OSHA's notice of proposed rulemaking for occupational exposure to trichloro- ethylene (TCE) reviews the general toxic effects of the compound and the results of tests measuring its effects on animals and humans. The proposed new standard, which would retain the current 8-hour time-weighted average limit for exposure to airborne concentrations of TCE of 100 ppm but would reduce the ceiling limit from 200 ppm to 150 ppm and delete the acceptable maximum peak of 300 ppm for 5 minutes in any 2 hour period, follows receipt of an alert by OSHA from NCI and NIOSH that TCE may be a carcinogen. TRICHLOROETHYLENE See: 33-0020, Perchloroethylene See also: 33-0030, Vinyl Chloride -714- ------- 33-0025 SHALE OIL EXTRACTION AND REFINING Myers, G.A. PREREFINING OF SHALE OIL (Letter to Editor) Chem. Eng. News 53_ (44) : 5 (3 November 1975) The author points out an error in this journal's report of his paper presented at the ACS Chicago meeting (See CATS 28-0018). The last paragraph should have stated that several arsenic removal processes,,including caustic washing, were investigated. However, Atlantic Richfield's process, now available for licensing, is a different process, much more efficient than caustic washing. -215- ------- 33-0026 VINYL CHLORIDE Cascaval, C.N. et al PYROLYSIS-GAS CHROMATOGRAPHY OF POLYMERS OBTAINED BY FRIEDEL-CSAFTS REACTIONS OF POLY(VINYL CHLORIDE) WITH AROMATIC COMPOUNDS J. Polym. Sci., Polym. Chem. Ed. _13_(10): 2259-68 (1975) Pyrolysis gas chromatography was used successfully to determine the structure and the mechanism of the thermal degradation of some condensation polymers of PVC with benzene, toluene, and naphthalene. 33-0027 VINYL CHLORIDE Anon VINYL CHLORIDE AND BIRTH DEFECTS Sci. News 108 (19): 297 (8 November 1975) Testifying before the California State Senate, Joseph Wagoner, director of field studies for NIOSH, reported that people living near PVC manufacturing plants run the risk of giving birth to children with birth defects and adults may develop brain tumors. He cited the reported studies by Peter F. Infante covering three Ohio towns where PVC is made. (See also: CATS 26-0024) -216- ------- 33-0028 VINYL CHLORIDE Anon A JAPANESE NATIONAL SAFETY STANDARD FOR VINYL CHLORIDE. . . Chem. Eng. News ,5_3 (45): 10 (10 November 1975) Following the death from liver cancer of a Nagoya worker exposed to vinyl chloride for a long time, Japan may establish a national safety standard for VC before the end of 1975. A provisional 2 ppm limit inside monomer plants has been established and workers exposed to VC have been asked to get medical examinations. 33-0029 VINYL CHLORIDE (Markets) Anon PVC FACES MARKET LOSSES, BUT WILL SURVIVE Chem. Eng. News 53_ (45) : 13-4 (10 November 1975) The polyvinyl chloride industry will evidently not suffer the decline anti- cipated when it was first learned that vinyl chloride caused cancers, prima- rily because of production improvements minimizing the unpolymerized VC content of PVC. Proposed government regulations may cause a decline in food- related PVC markets, especially if these regulations affect piping for potable water but, in general, PVC should retain a strong market. Potential competitors for PVC are oriented polypropylene in the food market and the new polyolefin elastomers (from Du Pont, Exxon, B.F. Goodrich, Hercules, and Uniroyal), which are cutting into PVC's use for auto sight shields, wire and cable jacketing, gaskets, specialty tubing, and sporting goods. -217- ------- 33-0030 VINYL CHLORIDE Reynolds, Edward S. et al HEPATOXICITY OF VINYL CHLORIDE AND 1,1-DICHLOROETHYLENE Am. J. Pathol. .§1^(1): 219-36 (October 1975) Rats pretreated with phenobarbital before receiving a single 5-hr exposure to 5% VCM (reported in an earlier study) developed acute liver injury. In this study, pretreatment with Aroclor 1254 produced similar results. The hepatoxic effects of phenobarbitol pretreatment seem to result from an increase or change in the metabolism of diverse halocarbons traced to the mixed function oxidase system (MFOS). Comparison is made with the liver injuries caused by 1,1-dichloro- ethylene and trichloroethylene under certain conditions. This study of the role of differential induction of MFOS components by zenobiotics in the acute responses of animals to vinyl chloride and 1,1-dichloroethylene indicates a need to determine the basic chemical processes involved in vinyl chloride injury. -218- ------- 33-0031 VINYLIDENE CHLORIDE (Production) Anon VINYLIDENE CHLORIDE Chem. Eng. News _53 (45): 14 (10 November 1975) When completed in 1978, the expansion of PPG's Lake Charles, La., facility should add over 50 million Ib/yr to the company's vinylldene chloride capacity. -219- ------- 33-0032 NITROSAMINES Liener, Irvin E., editor TOXIC CONSTITUENTS OF ANIMAL FOODSTUFFS Academic Press, NYC, 1974. 222 pp. $31.00 This book on food science and technology contains a section on nitrosamines, written by N.P. Sen, according to a recent announcement in "Current Contents - Life Sciences". 33-0033 NITROSAMINES Fine, David H. et al ANALYSIS OF VOLATILE N-NITROSO COMPOUNDS IN DRINKING WATER AT THE PART PER TRILLION LEVEL Bull. Environ. Contam. Toxicol. 14 (4): 404-8 (October 1975) Examination of water supplies in the New Orleans and Boston areas, using two different concentration and extraction methods, failed to show the presence of volatile N-nitrosamines in the water at the sub yg/1 level. Test procedures were based on liquid-liquid extraction and on adsorption of the organic fraction on carbon followed by extraction with chloroform and alcohol. -220- ------- 33-0034 NITROSAMINES Anon ADDITIVES ON WAY OUT? Chem. Week j.17 (18): 17 (29 October 1975) Following a report by USDA's panel on nitrites and .nitrosamines, the Agriculture Dept. may ban the use of nitrate additives and reduce permissible nitrite residue levels in meat and poultry products. Considering proposed limits on nitrite residues in bacon, which contains the highest levels of nitrosamines, USDA expects to recommend in December a level that will preclude nitrosamines formation. One difficulty is the lack of a nitrite substitute that would effectively prevent botulism. -221- ------- 33-0035 GENERAL INFORMATION Spence, J.W. et al EFFECTS OF GASEOUS POLLUTANTS ON PAINTS: A CHAMBER STUDY J. Paint Technol. 47^ (609): 57-63 (October 1975) As part of a long-range program to develop dose response relationships between environmental factors and exterior coatings, four types of exterior paints (oil-base house paint, acrylic latex house paint, vinyl coil coating, and acrylic coil coating) were exposed to sulfur dioxide, ozone, nitrogen dioxide, and humidity in a controlled environment. In more than 20,000 hours of exposure time, S02 concentration appeared to have a significant effect on the erosion rate of housepaints. In a regression analysis, SO- concentration and humidity governed 61% of the variability. Reaction of S0£ with the aluminum substrate voided the data on erosion rates of acrylic latex housepaints. For vinyl coil coating, S02 times relative humidity accounted for 34% of the varia- bility, but at the primary standard of 80 yg/cu m S02 the S02 apparently contributed to less than 5% of the erosion rate. Acrylic coil coating had the lowest erosion rates, affected primarily by ozone. Test results preclude the need of additional tests with the three pollutants, but the results are not necessarily representative of the erosion characteristics of an entire class of paints, which will be governed by particular paint components. Paints with calcium carbonate extenders might be more susceptible to S02. 33-0036 GENERAL INFORMATION Thomson, A.J. BIOCHEMISTRY OF TRANSITION METALS Nature 257 (5527): 536-7 (16 October 1975) Although the biochemical activities of Mn, Fe, Co, Cu, and Zn are well known, less is known about the other five elements of the first transition series. Vanadium, however, has been found in high concentrations in the blood cells of ascidians (sea squirts). The biological roles of chromium and nickel are now of interest, and the role of chromium in glucose metabolism in man and animals has been documented. Nickel, long considered biologically inactive, has now been reported in the blood sera of man and animals at certain levels, and jack bean urease has been identified as a metalloenzyme containing Ni. In addition to vanadium, Carlisle in 1968 reported the accumulation by some species of marine animals of Ti, Cr, Mn, Fe, and Ta, and the possible accumulation in these species of Mo, Zr, and W. -222- ------- 33-0037 GENERAL INFORMATION Anon AIR POLLUTION FROM SEWAGE TREATMENT PLANTS? Environ. Rep. _6 (12): 91 (31 October 1975) Potentially pathogenic bacteria may be present in the gaseous effluents discharged from sewage treatment plants, according to a study by the City University of New York in which certain such bacteria were detected in the atmosphere. Attention should be paid to facilities located upwind of those places in- habited by the young, the old, or the infirm, who may be prey to infections. Treatment plant workers may also be exposed. 33-0038 GENERAL INFORMATION Anon MICROWAVE EFFECTS PROCEEDINGS Environ. Rep. 6_(12): 92 (31 October 1975) Bureau of Radiological Health (HFX-25), 5600 Fishers Lane, Rockville, Md. 20852 has available some free copies of PB-739 554, the proceedings of an Oct. 1973 "International Symposium on the Biological Effects and Health Hazards of Micro- wave Radiation", which is also available at $10 from NTIS. -223- ------- 33-0039 GENERAL INFORMATION Proctor, Nick H. and Casida, John E. ORGANOPHOSPHORUS AND METHYL CARBAMATE INSECTICIDE TERATOGENESIS: DIMINISHED NAD IN CHICKEN EMBRYOS Science 190 (4214): 580-2 <7 November 1975) Increasing substitution of organophosphorus (OP) and methyl carbamate (MC) compounds for chlorinated pesticides necessitates an understanding of their potential health hazards. In this study of the mechanism of teratogenesis in chicken embryos it appears that the OP and MC teratogenic effects are related to the degree of reduction in the embryo nicotinamide adenine dinucleotide (NAD) levels. The data presented may be useful in assessing other types of biological activities of these pesticides, which are not associated with inhibition of acetylcholines terase. 33-0040 GENERAL INFORMATION Anon PLUTONIUM SHIPMENTS BY AIR. . . Environment 17. (8): 21 (November 1975) Following Congressman Aspin's concern that the import by air of hundreds of pounds of plutonium oxide could cause a disaster at Kennedy Airport in New York, or elsewhere, a new law has been passed that bans such shipments pending develop- ment of a crash- and explosion- proof container. As of 20 August 1975, the Nuclear Regulatory Commission suspended plutonium air shipments indefinitely. (See also: CATS 19-0038). -224- ------- 34-0001 ACETONITRILE (Uses) Anon CHEMICAL METHOD RECOVERS COPPER FROM ORE, TAILINGS Chem. Week 117 (21): 40 (19 November 1975) Air Products and Chemicals will study the economic feasibility of a reportedly promising technique to recover copper from ores or from copper tailings. In this Australian developed method cuprous sulfate solutions are leached from roasted copper concentrates using a not too expensive solvent, acetonitrile in water. The copper is recovered when the acetonitrile solution is distilled. Process advantages include operation under low-pressure steam and low SO- emissions. On the other hand, Anaconda rejected a similar process some months ago, when trials at its Butte, Montana smelter showed it to be not economical. -225- ------- 34-0002 ACRYLONITRILE (Markets) Anon SLOWER FIBER GROWTH Chem. Week 117 (22) : 16 (26 November 1975) Fiber market forecasters see a slow down in consumption in the coming years. Total world synthetic fiber consumption will increase 10%/year during the 1972- 1980 period, while world capacity will grow at 8%/year for the same period. Among raw materials, acrylonitrile could be in short supply in 1977 and 1980, based on the estimated demand for acrylic fibers. Additional acrylonitrile capacity is planned for 1981; help for U.S. demand may come from development of offshore acrylonitrile projects. -226- ------- 34-0003 ARSENIC Rossman, Toby et al EFFECTS OF SODIUM ARSENITE ON THE SURVIVAL OF UV-IRRADIATED ESCHERICHIA COLT: INHIBITION OF A recA-DEPENDENT FUNCTION Mutat..Res. 3Q (2): 157-62 (November" 3.975) Epidemiological and clinical data have linked arsenicals with cancer, particu- larly skin cancer, but animal studies have not confirmed these observations. To determine if arsenic compounds under certain conditions might be cocarcino- gens the authors investigated the possibility of arsenic compounds interfering with DNA repair. Sodium arsenite tested on E. aoli inhibited renair of UV- induced lesions in wild-type and excision-defective strains; the effect increased with increasing UV. The arsenite did not affect reoA strains, but increased the survival of exrA strains. These results indicate that, if arsenite is found to inhibit repair in eukaryotic cells, that could explain the cocarcinogenic effect of arsenic compounds. -227- ------- 34-0004 FLUOROCARBONS Lillian, Daniel et al ATMOSPHERIC FATES OF HALOGENATED COMPOUNDS Environ. Sci. Techno 1_. 9. (12): 1042-8 (November 1975) Maximum, minimum, and average concentrations of 11 halocarbons were obtained under various geographical and meteorological conditions at various U.S. urban and nonurban locations and over the ocean. Certain compounds (CC1 F, CC1?F2, CHoCClo and CC1/) were easily measurable and were found at all locations, generally in sub-ppb concentrations. Others were found primarily near urban areas; others only in areas where a possible source existed. Vinyl chloride appeared only in Delaware City, Del., in concentrations up to 1.5 ppm. The halocarbons are useful tracers of atmospheric transport. 34-0005 FLUOROCARBONS Jaffe, Richard J. CHLOROFLUOROCARBON PROBLEM (Letter to Editor) Chem. Eng. News 5_3 (47): 3 (24 November 1975) Pointing out that some precious letters on the subject contained misinformation, the writer spells out known facts on chlorofluorocarbons, which he concludes definitely indicate their implication in depleting the ozone layer of the earth. He recommends that provisional phasing out of "Freon" production should start now, while research is underway, with final or permanent action to follow after the studies are completed. -228- ------- 34-0006 ISOCYANATES Anon POLYURETHANE CHEMICALS ARE GOING STRONG AGAIN Chem. Eng. News 53_ (47): 7 (24 November 1975) Isocyanates, polyols and other polyurethane chemicals are selling well again, according to Union Carbide's R.H. Hughes. Carbide's polyurethane business started on the upward trend in the spring and has been going strong since July. Polyurethane chemicals, among the first casualties of the recession, might well serve as indicators for the status of the chemical industry in general. -229- ------- 34-0007 NAPHTHYLAMINES Swaffield, Laura CUTTING OUT CANCERS Nature 258 (5531): 94-5 (13 November 1975) The ILO set forth a Convention and a Recommendation on international standards to protect workers against carcinogens, which should help in establishing useful principles and counteracting past abuses. However, the documents cover only known carcinogens. Difficulties in determining limits for standardized international agreements for occupational exposure levels are illustrated by contrasting industry's action on two chemicals. Although 2-naphthylamine was considered a potential carcinogen in 1938, some companies did not start screening workers until 1960 or 1965. By 1970, about 450 workers were found to have bladder cancer. On the other hand, VCM-caused angiosarcomas were discovered in early 1974 and, by mid-1974, England's Dept. of Employment was working to lower the threshold limit value of VCM from 50 to 25 ppm. -230- ------- 34-0008 POLYURETHANES (Markets) Anon PETER SHERWOOD ASSOCIATES, INC. . . . Rubber Age 107 (11): 6 (1975) Increasing markets for polyurethane are predicted in a multi-client study by Peter Sherwood Associates, Inc., N.Y.C. The optimistic estimates given may actually be too low. POLYURETHANES See: 34-0006, Isocyanates -231- ------- 34-0009 VINYL CHLORIDE (Production) Anon SEEKING VCM SUPPLY Chem. Week 117 (21): 13 (19 November 1975) Needing more vinyl chloride, Robintech Inc. (Fort Worth, Texas) seeks to buy a major chemical complex, probably Allied Chemical's Baton Rouge, La., plant with an estimated annual capacity of 300 million Ib. VCM, which would supply Robintech's PVC unit at Painesville, Ohio. Shintech, jointly owned by Robintech and Shin-Etsu of Japan, operates a 220-million- Ib/yr PVC plant at Freeport, Texas, which receives VCM from Dow's Freeport plant. Dow is expanding its plant to 330 million Ib/yr of VCM, a 50% increase. 34-0010 VINYL CHLORIDE Anon PULLING OUT OF PVC Chem. Week 117 (22): 14 (26 November 1975) Increasing costs, particularly those necessitated by OSHA's standards and EPA emissions rules, prompted Uniroyal Chemical to phase out all PVC resin production at its 125-130-million-lb/yr Painesville, Ohio plant. -232- ------- VINYL CHLORIDE See: *34-0004, Fluorocarbons 34-0007, Naphthylamines -233- ------- 34-0011 GENERAL INFORMATION Anon TREES GET THEIR SIGNALS CROSSED: THE CULPRIT IS SECURITY LIGHTING NTS Environ. ,5 (5): 9 (November 1975) High pressure sodium street lights are affecting the growth patterns of 16 or more tree species, with some trees continuing to grow during Fall. Such rapid growth in the wrong season makes the trees, and their leaves, more sensitive to the harmful effects of air pollutants. 34-0012 GENERAL INFORMATION Beil, Karen M. COKE OVENS VERSUS PUBLIC HEALTH NYS Environ. ^ (5): 4 (November 1975) According to Dr. Beverly Paigen, Roswell Park Memorial Institute, Buffalo, 25% of coke oven workers, who work on top of the ovens for at least 5 years, will die of lung cancer. She traces the cause of the cancer to benzo(a)pyrene and indicates that individuals with a higher level of the enzyme, aryl hydrocarbon hydroxylase, are more susceptible. Coke ovens are responsible for 97% of the benzo(a)pyrene in Erie County air. Bethlehem Steel emits 8.5 tons/yr, Donner- Hanna, 2.5 tons; and Allied Chemical Semet Solvey Division, 1" ton. -234- ------- 34-0013 GENERAL INFORMATION Anon EARTHWORMS AS MONITORS OF HEAVY METALS IN SEWAGE SLUDGE? Environ. Sci. Tech. 9_ (12): 1008 (November 1975) Soil scientists at the University of Wisconsin-Madison report earthworms take up metals in the soil and then, when placed in "clean" soil, release the metals, Tests were made with radioactive cobalt, cadmium, zinc and mercury, indicating that the worms may be used to monitor heavy metals in sewage sludge. 34-0014 GENERAL INFORMATION Rosenkranz, Herbert S. et al CHLOROPROPANOL, A MUTAGENIC RESIDUE RESULTING FROM PROPYLENE OXIDE STERILIZATION Mutat. Res. J30 (2): 303-4 (November 1975) The fumigant, propylene oxide, has been widely used to sterilize cereals, dried fruits fruits, cocoa, etc. During sterilization procedures the non-volatile residual chloropropanols (l-chloro-2-propanol and 2-chloro-l-propanol) are formed. A preparation containing these compounds was found to be mutagenic to Salmonella typhimwrium TA1530. Because consumption of 1 Ib of fumigated food may cause an intake of up to 21 mg of l-chloro-2-propanol, daily intake could be high. Alter- nate sterilization methods should be sought and animal carcinogenicity studies are recommended. -235- ------- 34-0015 GENERAL INFORMATION Anon WATER FLUORIDATION DOES NOT CAUSE CANCER. . . Chem. Eng. News 53 (47) : 25 (24 November 1975) After studying cancer mortality patterns over a 15-year period in areas with 95% of the population exposed to fluorides in water, the NCI has concluded that fluoridation does not cause cancer. Where there were high levels of natural fluorides, there was less mortality from brain and nervous system cancers. 34-0016 GENERAL INFORMATION Anon THALLIUM TENDS TO SETTLE INTO STREAM SEDIMENT. . . Chem. Eng. News 53_ (47) : 25 (24 November 1975) In a study for EPA, Calspan Corp. reported that thallium seems to settle into stream sediment instead of moving up through the food chain. Heavy metals tend to accumulate more in rooted plants than in algae, fish, or other biota. -236- ------- ACETONITRILE See: 35-0001, Acrylonitrile -237- ------- 35-0001 ACRYLONITRILE Anon ACRYLONITRILE (Sohio Process) - The Badger Co., Inc. Hydrocarbon Process^ 5_4_ (11): 108 (November 1975) Reactor operating conditions are illustrated for the production of acrylonitrile from propylene, anhydrous fertilizer grade ammonia and air. Fluid-bed catalyst (catalyst 41) now used in process increases yield of acrylonitrile over that obtained previously. Possible by-products are high-purity HCN and acetonitrile. Process, used in 45 or more plants (with annual capacities of approximately 20 million to 350 million Ib), accounts for world-wide capacity of over 5 billion Ib/yr acrylonitrile. 35-0002 ACRYLONITRILE Anon REICHHOLD WILL BUY STANDARD BRANDS CHEMICAL FOR MORE THAN $20 MILLION Chem. Week 117 (24): 13 (10 December 1975) Purchase of Standard Brands Chemical Industries, Dover, Delaware, by Reichhold Chemicals, White Plains, New York, for over $20 million is expected in January 1976. This subsidiary of Standard Brands with annual sales of $45-50 million is big producer of polymers and latexes, including acrylonitrile. -238- ------- 35-0003 ARSENIC Matsumoto, N. et al FETAL BODY BURDEN OF CHEMICALS AND ITS EFFECT ON FETAL GROWTH Abstract of Paper Presented at 15th Annual Meeting of the Congenital Anomalies Research Association of Japan, Tokyo, Japan, November 7-9, 1975 in: Teratology 12 (2): 203 (October 1975) Arsenic, lithium, cadmium and chromium were used in experiments designed to determine the distribution of chemicals among maternal-placento-fetal units (species not identified) and dose-response relationship. Fetal tissues retained arsenic long after administration. Higher doses of arsenic resulted in lower- weight fetuses at day 18 of gestation. Intra uterine growth retardation was observed with all the chemicals. 35-0004 ARSENIC Wilshire, Frank W. et al RAPID RADIOCHEMICAL SEPARATION OF SELECTED TOXIC ELEMENTS IN ENVIRONMENTAL SAMPLES PRIOR TO GAMMA RAY SPECTROMETRY Anal. Chem. 47 (14): 2399-2403 (December 1975) Liquid anion exchange, using triisooctylamine, successfully separated the radio- active isotopes of arsenic, cadmium, mercury, selenium, iodine, and zinc, permitting more accurate analysis of environmental samples by gamma ray spectro- metry. -239- ------- 35-0005 ARSENIC Anon NAS PANEL UPHOLDS EPA's PESTICIDES POLICY Chem. Eng, News 5_3 (49): 17 (December 8, 1975) In Its "Contemporary Pest Control Practices and Prospects", a report to be published in January 1976, the NAS Consultative Panel on Health Hazards of Chemical Pesticides approves EPA's "nine principles" of carcinogenicity on which EPA bases its pesticide decisions. The Panel reports that the increase in deaths from lung and pancreas cancers and from leukemia was apparent before the widespread use of synthetic organic pesticides. Except for arsenic, many human carcinogens (e.g., asbestos,' benzidine, bis(chloromethyl) ether, vinyl chloride, 2-naphthylamine) have been found to be carcinogens in test animals. The Panel reports that a life-time human incidence on a dose-per-body-weight basis, based on animal tests, can be accurately predicted for such carcinogens as benzidine, vinyl chloride and four others. -240- ------- ASBESTOS See: 35-0005, Arsenic See also; 35-0033 Vinyl chloride -241- ------- 35-0006 BENZIDINE Vesselinovitch, S.D. et al FACTORS MODULATING BENZIDINE CARCINOGENICITY BIOASSAY Cancer Res. 35 (10): 2814-9 (1975) Adult mice given benzidine dihydrochloride in their diet for 84 weeks (at dose levels of 50, 100, or 150 ppm) developed dose-related liver tumors, with females showing the greater susceptibility. When benzidine was given by stomach in- tubation over the same period of time, the carcinogenic effects were more evident in the lung than in the liver. Male mice receiving 150 ppm of benzidine dihydro- chloride for only 39 or 44 weeks had a higher incidence of liver tumors than those eating the compound for 84 weeks. When infant mice were given 30 yg/day of. benzidine by stomach intubation, only the males developed liver tumors. BENZIDINE See: 35-0005, Arsenic -242- ------- 35-0007 BORON McGinley, John R. and Schweikert, Emile A. DETERMINATION OF LITHIUM, BORON, AND CARBON BY QUASI-PROMPT CHARGED PARTICLE ACTIVATION ANALYSIS Anal. Chem. t\]_ (14): 2403-7 (December 1975) Charged particle bombardment of lithium, boron, and carbon provides a rapid, sensitive method for the nondestructive trace analysis of these elements in botanical specimens and other materials. ------- 35-0008 FLAME RETARDANTS Anon DIAMOND SHAMROCK. . . Chem. Eng. J52_ (25): 23 (24 November 1975) New 90-million Ib/yr chlorinated paraffins plant planned for 1977 operation by Diamond Shamrock Corp. near Houston, Texas, will triple capacity of company, which now operates a plant at Painesville, Ohio. Product is expected to be used as fire-retardant additives. 35-0009 FLAME RETARDANTS Anon MOBIL CHEMICAL. . . Chem. Eng. 82_ (25): 90 (24 November 1975) Trimethyl phosphite, intermediate in flame retardants and non-persistent crop chemicals, will be available in greater amounts when Mobil Chemical Co. goes onstream in 1977 with new Charleston, S.C., plant. -244- ------- 35-0010 FLAME RETAKDANTS (Use) Anon CHEMICALS LIMIT BLAZE DAMAGE Chem. Week 117 (23) : 16 (3 December 1975) Phos-Chek monoammonium phosphate, flame retardant manufactured by Monsanto, was used to combat recent forest fires near Los Angeles. Over 20 million gal/yr of flame retardants are used for fighting forest fires. -245- ------- 35-0011 FLUORQCARBONS Telegadas, K. and Ferber, G.J. ATMOSPHERIC CONCENTRATIONS AND INVENTORY OF KRYPTON-85 IN 1973 Science 190 (4217): 882-3 (28 November 1975) From concentrations of krypton-85 measured in the atmosphere in 1973 at 1.5 to 20 kilometers, the total global burden of this radioisotope in the atmosphere was calculated to be 53 Me. An increasing concentration of krypton-85 in the atmosphere has resulted from nuclear industry growth over the last 20 years. The distribution of fluorocarbon-11 in the stratospheric resembles that of krypton-85. Both are inert gases but, if fluorocarbon-11 dissociates, its distribution above 20 km should be different from that of krypton-85. Because the latter has no sink in the region above 20 km and its half-life (10.76 years) is known, comparisons of its distribution with that of fluorocarbon-11 might provide data useful in analyzing the stratospheric ozone depletion problem. 35-0012 FLUOROCARBONS Anon VOLCANO MAY TEST OZONE THEORY Household and Pers. Prod. Ind. 12_ (11): 8 (1975) The expected eruption of a volcano in Alaska may offer a means of testing the ozone depletion theory, according to Dr. J.P. Lodge, new advisor to the Council on Atmospheric Sciences. Earlier, the eruption of Mount Agung in Bali, while emitting much chlorine into the atmosphere, did not cause the effect in the stratosphere that had been anticipated. -246- ------- 35-0013 FLUOROCARBONS Anon DATA ON OZONE, DRINKING WATER REFINED Chem. Eng. News 53_ (49): 6 (8 December 1975) Scientists present at the First Chemical Congress of the North American Continent, Mexico City, were told by Rowland and Molina (Univ. of California, Irvine) that they had confirmed that the absorption cross section of F-12 at 2139 A in the stratosphere is lower than at room temperatures, but that over the entire wave length range and stratospheric temperature range their new calculations show that the weighted absorption cross sections are only about 20% smaller than those at room temperature. Their measurements indicate a 10% longer atmospheric residence time for F-12. Similar results were obtained with chlorofluorocarbon-11. -247- ------- 35-0014 HALOETHERS Van Duuren, Benjamin L. et al CARCINOGENIC ACTIVITY OF DI- AND TRIFUNCTIONAL ct-CHLORO ETHERS AND OF 1,4-DICHLORO- BUTENE-2 IN ICR/HA SWISS MICE Cancer Res. 35_ (9): 2553-7 (1975) Five a-chloro ethers and trans-l,4-dichlorobutene-2 were tested for carcinogenicity in female mice. Bis-1,2(chloromethoxy)ethane, bis-1,4(chloromethoxy)-p-xylene, and tris-l,2,3(chloromethoxy)propane all caused a high degree of tumors, whether applied to the skin or injected by the i.p. or s.c. route. Bis-1,4(chloromethoxy) butane, bis-l,6(chloromethoxy)hexane, and trans-l,4-dichlorobutene-2 caused few tumors or were inactive by one or more routes of administrations. Bis-1,4(chloro- methoxy) -p-xylene was the most carcinogenic of the compounds tested. HALOETHERS See: 35-0005, Arsenic -248- ------- 35-0015 HEXACHLOROBENZENE Stonard, M.D. MIXED TYPE HEPATIC MICROSOMAL ENZYME INDUCTION BY HEXACHLOROBENZENE Biochem. Pharmacol. 2^ (21): 1959-63 (1 November 1975) Microsomal spectral changes induced by hexachlorobenzene (HCB) were compared with those induced by 3-methylcholanthrene and phenobarbitone. Apparently, HCB, which causes a mixed type induction, including the microsomal changes induced by both phenobarbitone and 3-methylcholanthrene. -249- ------- 35-0016 HYDRAZINE Wyrobek, A.J. and Bruce, W.R. CHEMICAL INDUCTION OF SPERM ABNORMALITIES IN MICE Proc. Nat. Acad. Sci. U.S.A. _72. (11): 4425-9 (1975)' Examination of the sperm of mice given 5 consecutive, daily intraperitoneal injections of 25 potentially mutagenic, teratogenic or carcinogenic chemicals were examined at 1, 4, and 10 weeks after the end of exposure. Elevated levels of sperm abnormalities were induced by 19 of the chemicals, but not by 1,1-di- methylhydrazine, dimethylnitrosamine, urethane, DDT [l,l,l-trichloro-2,2-bis (p-chlorophenyl)ethane], caffeine, and calcium cyclamate. HYDRAZINE See also: 35-0037, Nitrosamines -250- ------- 35-0017 LIQUEFACTION AND GASIFICATION OF COAL Anon COAL CONVERSION ACTIVITIES PICKING UP Chem. Eng. News .53 (48): 5 (1 December 1975) Legislative and financial problems rather than a lack of confidence in the technical feasibility of coal conversion processes have been impeding the development of a U.S. coal conversion industry. Federal and state support is needed to get industry and banks to start moving, and the recent action of the state of Illinois in providing $70 million in bonding to help support demonstration projects has already prompted a move by Coalcon Co. to start a demonstration plant. Major coal conversion processes under consideration for U.S. exploitation are reviewed briefly. -251- ------- NAPHTHYLAMINES See: 35-0005, Arsenic -252- ------- 35-0018 PERCHLOROETHYLENE Anon PERCHLOROETHYLENE-TRICHLOROETHYLENE PPG INDUSTRIES, INC. Hydrocarbon Process. 54 (11): 169 (1975) Flowsheet describes oxychlorination/oxyhydrochlorination process for making perchloroethylene and trichloroethylene with no by-product HC1, using as starting materials ethylene dichloride, recycled chlorinated organics, chlorine, and oxygen. By-product streams from vinyl chloride plants can also by used as process feedstock in this single-step PPG process. World-wide per— and trichloro- ethylene production capacity for plants (existing or being built) using this process is about 1 billion Ib/yr. 35-0019 PERCHLOROETHYLENE Greim, H. et al MUTAGENICITY IN VITRO AND POTENTIAL CARCINOGENICITY OF CHLORINATED ETHYLENES AS A FUNCTION OF METABOLIC OXIRANE FORMATION Biochem. Pharmacol. 2£ (21): 2013-7 (1 November 1975) The mutagenicity of the chlorinated ethylenes (tetrachloroethylene, cis- and trans-l,2-dichloroethylene, 1,1-dichloroethylene, and vinyl chloride) were determined with a metabolic activating microsomal enzyme system in vitro. A wide variation in the cytotoxicity of these compounds was noted. For 80-100% survival of the tester strain only 1 mM of trichloroethylene.could be used versus 10 mM of vinyl chloride. Mutagenic activity depended upon microsomal enzyme activity. VCM was more mutagenic than trichloroethylene and 1,1-dichloro- ethylene. The other 3 compounds were not metabolized to mutagens. -253- ------- PERCHLOROETHYLENE See also: 35-0033, Vinyl chloride -254- ------- 35-0020 PHTHALATES Anon CONFERENCE TAPS WATER-QUALITY ISSUES Chem. Week 117 (24): 52-3 (10 December 1975) At the First Chemical Congress of the North American Continent, held recently in Mexico City, EPA researchers discussed factors governing presence of volatile organics in drinking water and reported that minute concentrations of a phthalate ester had been detected in samples of water from the Gulf of Mexico. In another report, T.C. Shields of Ashland Oil announced the development of a new fuel additive, identified only as AMD-4, which is said to be more effective than MD (N,N'-disalicylidine-l,2-propanediamine), the standard antioxidant used since the 1940's to prevent metals in tanks and engines from catalyzing the oxidation of gasoline and diesel fuels. -255- ------- 35-0021 POLYURETHANES (Uses) Anon PLASTIC SCREENS VANQUISH ABRASIVES Chem. Eng. 8£ (25): 35 (24 November 1975) C.E. Tyler Industrial Products, Mentor, Ohio, claims new steel-reinforced poly- urethane (Tyrethane) screens that can be used to classify crushed stone, iron and copper ores, coal, sand» gravel, and some chemicals are more abrasion- resistant, last longer, and more economical than woven wire cloth screens. 35-0022 POLYURETHANES Nomura, T. TERATOGENESIS AND CARCINOGENESIS BY URETHAN IN MICE Abstract of Paper Presented at 15th Annual Meeting of the Congenital Anomalies Res. Assoc. of Japan, Tokyo, Japan, November 7-9, 1975 in: Teratology 12_ (2): 190 (October 1975) Pregnant mice were given from 0.2 to 1.5 mg/g body weight of urethan on days 3 to 19 of gestation and mortality, malformation, and tumor development were watched in the developing embryo. Malformation occurred only in organs exposed at the early stage of organogenesls. Maximum lung anomaly resulted from a dose of 1.5 mg/g on day 9; maximum liver anomaly occurred on day 8-. Malformation incidence dropped from 93 to 34% at 1.5 mg/g to almost zero at 1.0 mg/g. In contrast, lung and liver tumors developed from urethan given during late organo- genesis and fetal growth of each organ, even in amounts as small as 0.2 mg. -256- ------- 35-0023 POLYURETHANES Yasuda, Y. and Nishimura, H. A COMPARISON OF DIGITAL MALFORMATION INDUCED BY URETHANE IN VITRO WITH THOSE INDUCED IN VIVO. Abstract of aper Presented at 15th Annual Meeting of the Congenital Anomalies Res. Assoc. of Japan, Tokyo, Japan, November 7-9, 1975 in: Teratology 12_ (2): 218-9 (October 1975) Pre- and postaxial polydactyly were induced when hind limbs from 13-day mouse embryos were cultured with 0. 10, 50 pr 100 yg/ml on a liquid medium for 2 days. Administration of urethane in vivo on day 8 or 9 of gestation induced polydactyly in the hind limbs and adactyly or syndactyly after administration on day 10 of pregnancy, suggesting a possible difference in in vivo and in vitro digital malformation mechanisms. 35-0024 POLYURETHANES Matsuyama, Mutsushi et al ULTRASTRUCTURE OF SPONTANEOUS AND URETHAN-INDUCED THYMOMAS IN BUFFALO RATS Cancer Res. 35_ (10): 2771-9 (1975) Electron microscopy was used to compare normal thymuses of rats and spontaneous and urethane thymomas induced in rats by urethane. -257- ------- POLYURETHANES See: 35-0016, Hydrazine -258- ------- 35-0025 SHALE OIL EXTRACTION AND REFINING Anon A SHALE OIL PROJECT. . . Chem. Eng. 82_ (26): 81 (8 December 1975) American Lurgi Corp. and Dravo Corp. will build a 4,000 ton/day shale oil plant, based on Lurgi-Ruhrgas coal-gasification technology, in western U.S. in next 2 or 3 years. Possible cost: $25-30 million. Environmental advantages: low NO and S02 emissions. -259- ------- TRICHLOROETHYLENE See: 35-0018, Perchloroethylene See: 35-0019, Perchloroethylene See also: 35-0033, Vinyl chloride -260- ------- 35-0026 VINYL CHLORIDE Anon VINYL CHLORIDE ~ B.F. GOODRICH CHEMICAL CO. Hydrocarbon Process. j>4_ (11): 214 (1975) Flowsheet and brief description of B.F. Goodrich process for making vinyl chloride monomer and ethylene dichloride from ethylene, chlorine, and air. In 31 plants (now operating or in building throughout the world) using this process, annual capacity is 13 billion Ib of ethylene dichloride and 11 billion Ib of vinyl chloride. 35-0027 VINYL CHLORIDE Anon VINYL CHLORIDE ~ PPG INDUSTRIES, INC. Hydrocarbon Process. 54, (11): 215 (1975) Ethylene, oxygen, chlorine and hydrogen chloride are used to make vinyl chloride monomer by the described (including flowsheet) PPG Industries process. World- wide plants (current and near-future) using process have annual capacities of over 3.8 million Ib of ethylene dichloride and 2 billion Ib of VCM. -261- ------- 35-0028 VINYL CHLORIDE Anon VINYL CHLORIDE (MONSANTO CO.) — SCIENTIFIC DESIGN CO., INC. Hydrocarbon Process. 5.4. (11): 217 (1975) Flowsheet and brief description of VCM manufacture from ethylene, chlorine, air or oxygen. 35-0029 VINYL CHLORIDE lammartino, Nicholas 31. PVC MAKERS MOVE TO MOP UP MONOMER EMISSIONS Chem. Eng. 82^ (25): 25-7 (24 November 1975) Polyvinyl chloride manufacturers are bracing for the 1 April deadline of meeting OSHA's stringent standards for VC. Larger, newer plants report achieving lower than 1 ppm for most normal operations; smaller, older plants may have difficulties, especially since EPA may move to regulate VC emissions to neighborhoods near plants. One announced casualty: Uniroyal Chemical will close dcwn its ancient Painesville, Ohio, plant. Production changes and other means taken by various companies to reduce emissions are reviewed briefly. -262- ------- 35-0030 VINYL CHLORIDE Anon POLYVINYL CHLORIDE CAPACITY GETS A BOOST Chem. Eng. 82_ (24): 123 (10 November 1975) Firestone Plastics Co's new 50-million-lb/yr plant at Perryville, Md., makes it largest U.S. producer of PVC dispersion resins, made via a German continuous polymerization process with new spray-drying technique. Plant meets OSHA standards on VC monomer emissions: respirators may be needed in some instances. Firestone Plastics anticipates no problem in meeting EPA limits of residual monomer content of polymer product. 35-0031 VINYL CHLORIDE Huberman, Eliezer et al MUTATION INDUCTION IN CHINESE HAMSTER V79 CELLS BY TWO VINYL CHLORIDE METABOLITES CHLOROETHYLENE OXIDE AND 2-CHLOROACETALDEHYDE Int. J. Cancer 16_ (4): 639-44 (15 October 1975) A dose-dependent induction of 8-azaguanine-and ouabain-resistant mutants in a mammalian cell system (Chinese hamster V79 cells) in vitro is reported for chloroethylene oxide and 2-chloroacetaldehyde, which are thought to be potent- ially carcinogenic metabolites of vinyl chloride in mammals. For both com- pounds, mutation frequency of 8-azaguanine resistance at a concentration of 6 yM was 4 or 13 times that of the control; at a concentration of 13 yM chloro- ethylene oxide, mutation frequency with 8-azaguanine or ouabain resistance reached 8 or 23 times, resp. Under 2.5 mM, 2 chloroethanol or monochloroacetic acid, a urinary VC metabolite in man and rats, did not induce 8-azaguanine-and ouabain-resistant mutants. -263- ------- 35-0032 VINYL CHLORIDE Barbin, A. et al LIVER-MICROSOME-MEDIATED FORMATION OF ALKYLATING AGENTS FROM VINYL BROMIDE AND VINYL CHLORIDE Biochera. Biophys. Res. Commun. 67. (2): 596-603 (1975) Mixtures of vinyl chloride/oxygen or vinyl bromide/air were passed through a mouse-liver microsomal system. The resulting volatile alkylating metabolites, trapped by a reaction with 4-(4-nitrobenzyl)pyridine in ethylene glycol, had absorption spectra similar to those of chloroethylene oxide and 4-(4-nitro- benzyl) pyridine. The compound, 2-chloroacetaldehyde had a different spectrum. The results indicate that both vinyl chloride and vinyl bromide are changed by microsomal enzymes into their corresponding epoxides. The latter react with 4-(4-nitrobenzyl) pyridine to give similar adducts. 35-0033 VINYL CHLORIDE (Market) Anon THE VINYL CHLORIDE OUTLOOK IS BRIGHT. . . Chem. Eng. 82^ (26): 79-80 (8 December 1975) Optimistic outlook for VC should boost demand for chlorine feedstock by 8%/yr, according to Olin Corp., which plans to have a new $100-million chlor-alkali unit onstream in 1978 at Mclntosh, Alabama. New unit will boost Olin's capacity by 60%, adding 1,000 tons of chlorine and 1,100 tons of caustic. Process to be used in Hooker Chemical's H4 diaphragm cells with resin-stabi- lized asbestos diaphragms. -264- ------- 35-0034 VINYL CHLORIDE Anon PVC TAGS ARE RAISED BY ROBINTECH AND TENNECO Chem. Week 117 (24) : 23 (10 December 1975) Robintech and Tenneco Chemicals have raised PVC price to 25 and 240/lb, resp. PPG has already raised the price of VCM and Dow will push its price for the monomer up 1.6C to 12.6£/lb as of 1 Jan. 1976. They will also ask an additional for perchloroethylene and trichloroethylene. 35-0035 VINYL CHLORIDE Anon GOODRICH CUTS COST OF MEETING VCM LIMITS Chem. Week 117 (24): 59 (10 December 1975) B.F. Goodrich reports that it over-estimated the cost ($42 million est.) of meeting OSHA's VCM limits by 1977. Company feels this cost can be cut by 10-15% as a result of large-scale R & D effort, which has resulted in proprietary stripping and reactor cleaning techniques. Goodrich looks optimistically at industry future, predicting 40% increase (to 7 billion Ib) by 1980. -265- ------- VINYL CHLORIDE See: 35-0005, Arsenic See: 35-0018, Perchloroethylene See: 35-0019, Perchloroethylene -266- ------- 35-0036 NITROSAMINES Hasebe, Kiyoshi and Osteryoung, Janet DIFFERENTIAL PULSE POLARQRAPHIC DETERMINATION OF SOME CARCINOGENIC NITROSAMINES Anal. Chem. 47_ (14): 2412-8 (December 1975) Results of the Pulse polarographic analysis of N-nitrosopyrrolidine and its derivatives, N-nitrosoproline and N-nitroso-4-hydroxyproline, in buffered solution at varying pH are discussed. The study took into account the following factors: temperature, mercury pressure, modulation amplitude, surfactant concentration, solvent and supporting electrolyte. The potential carcinogenicity, mutagenicity, or teratogenicity of some N-nitrosamines prompted the study. 35-0037 NITROSAMINES Anon FUEL PLANT UNDER FIRE Chem. Week 117 (24) : 21 (10 December 1975) Maryland state health officials seek to close FMC's Baltimore rocket fuel plant following EPA findings showing 12 ppb of dimethylnitrosamine (DMN) in air near plant. FMC uses DMN, a suspected carcinogen, to make unsymmetrical dimethyl- hydrazine. FMC claims no reported serious illnesses from DMN at its plant. Meanwhile, EPA is sampling air near plants in Belle, W. Va., and in the Kanawha Valley. Although no nitrosamines have been detected in these areas, EPA is concerned that atmospheric nitrosamines may form from amines .and nitrogen oxides. -267- ------- 35-0038 NITROSAMINES Anon POTENT MUTAGEN SYNTHESIZED AT NIH Chem. Eng. News .53_ (49): 28 (8 December 1975) An extremely potent mutagen, a diol epoxide of benzo[a]pyrene, has been synthe- sized in a National Institutes of Health program seeking potential metabolites of the carcinogenic compound, benzo[a]pyrene. The new mutagen is much more active than ethyl methane sulfonate or N-methyl-N'-nitro-N-nitrosoguanidine. 35-0039 NITROSAMINES Frantz, C.N. and Mailing, H.V. FACTORS AFFECTING METABOLISM AND MUTAGENICITY OF DIMETHYLNITROSAMINE AND DIETHYLNITROSAMINE Cancer Res. 35_ (9): 2307-14 (1975) Dimethylnitrosamine (DMN) has been identified as a carcinogen, mutagen, and hepatoxin. Mutations from its microsomal metabolism increased linearly with time for 30 minutes of incubation in tests using Salmonella typhimurium. Metabolism of DMN to a mutagen may depend upon DMN demethylase activity. Hepatic dealkylation of DMN and diethylnitrosamine in rats and mice was in- creased by 3-MC (a standard enzyme) and phenobarbital induction. -268- ------- 35-0040 NITROSAMINES Rogers, Adrienne E. VARIABLE EFFECTS OF A LIPOTROPE-DEFICIENT, HIGH-FAT DIET ON CHEMICAL CARCINO- GENESIS IN RATS Cancer Res. 35_ (9): 2469-74 (1975) In this study in which rats were fed a marginally lipotrope-deficient, high- fat diet or an adequate diet and treated various chemicals, including N-methyl- N-nitroso-N'-nitroguanidine (MNNG), liver tumors were induced more rapidly and in greater numbers in rats on the deficient diets by N-2-fluorenylacetamide and other compounds tested. However, with MNNG there was no dietary effect on induction of gastric tumors. 35-0041 NITROSAMINES Mohr, Ulrich et al TRANSPLACENTAL EFFECTS OF DIETHYLNITROSAMINE IN SYRIAN HAMSTERS AS RELATED TO DIFFERENT DAYS OF ADMINISTRATION DURING PREGNANCY J. Nat. Cancer Inst. 55. (3): 681-3 (September 1975) Diethylnitrosamine (DEN) was administered to pregnant Syrian hamsters in a single sc dose (45 mg DEN/kg body wt) on 1 of the 15 days of pregnancy. Respiratory tract tumors occurred only in offspring of mothers who received the DEN on 1 of the last 4 days of pregnancy. The incidence rate was as high as 95%. Tumors developed, however, in the suprarenal glands, forestomach, liver and thyroid of offspring of mothers given DEN on days 1 through 11, indicating that the fetal respiratory epithelium has to attain a certain degree of differentiation to be susceptible to the carcinogenic effect of DEN. -269- ------- 35-0042 NITROSAMINES Mlrvish, Sidney S. INDUCTION OF MOUSE LUNG ADENOMAS BY AMINES OR UREAS PLUS NITRITE AND BY N-NITROSO COMPOUNDS: EFFECT OF ASCORBATE, GALLIC ACID, THIOCYANATE, AND CAFFEINE J. Nat. Cancer Inst. _55_ (3): 633-6 (September 1975) Mononitrosopiperazine (MNP), N-nitrosomorpholine (NM), and methylnltrosourea (MNU) were given to mice in varying concentrations in their drinking water. All three compounds induced lung adenomas but the adenoma yield was apparently proportional to nitrosamlne concentration for NM and MNP at low concentration. At a three times greater concentration of MNU, adenoma yield rose 12.5 times. Sodium ascorbate and gallic acid proved useful for blocking in vivo nitrosation and it is suggested that one of these compounds be administered with readily nitrosatable drugs. 35-0043 NITROSAMINES Low, Hans NITROSO COMPOUNDS. SAFETY AND PUBLIC HEALTH Arch. Environ. Health 29; 256-60 (November 1974) The properties, carcinogenicity, and the mechanism of carcinogenesis for nitroso compounds are reviewed briefly. Man can be exposed to carcinogenic or potentially carcinogenic nitrosamines in his work, from his food, from drugs, etc. The extract from dried tobacco leaves was found to contain nitrosopiperidine. A paper published in Germany in 1967 recommended the use of the non-carcinogenic p-tolylsulfonylmethylnitrosamine instead of nitroso-methylurethane in the synthesis of diazomethane. -270- ------- 35-0044 NITROSAMINES Nettesheim, P. et al CARCINOGENIC AND COCARCINOGENIC EFFECTS OF INHALED SYNTHETIC SMOG AND FERRIC OXIDE PARTICLES J. Nat. Cancer Inst. 55. (1): 159-69 (July 1975) Syrian hamsters inhaled either synthetic smog, Fe^O^, or combination of the two, for 6 hr/day, 5 times/wk for life. Half of the test animals were given sc injections of diethylnitrosamine (DEN) 12 times a week (0.25 mg each dose). Results indicated that inhaled Fe203 particles enhanced the induction of DEN cancers in the lungs, while synthetic smog did not. Inhalation of Fe203 or synthetic smog, alone or in combination did not cause cancers in the hamsters. Pulmonary fibrosis was noted in some animals exposed to Fe0-, and alveolar bronchiolization occurred in some exposed to synthetic smog. NITROSAMINES See: 35-0016, Hydrazine -271- ------- 35-0045 GENERAL INFORMATION Wilson, Hugh H. and Johnson, Larry D. CHARACTERIZATION OF AIR POLLUTANTS EMITTED FROM BRICK PLANT KILNS Ceram. Bull. 54_ (11): 990-1, 994 (1975) Atmospheric emissions from four U.S. brick plants were analyzed and the major pollutants were determined to be sulfur dioxide, sulfur trioxide, and fluorine. Other emissions in the stack gases were nitrogen oxides, chlorine, and particu- lates. Except for the S02 emissions at one plant, the emissions were not found to be of a magnitude to cause environmental concern. 35-0046 GENERAL INFORMATION Martin, J.H. and Broenkow, W.W. CADMIUM IN PLANKTON: ELEVATED CONCENTRATIONS OFF BAJA CALIFORNIA Science 190 (4217) : 884-5 (28 November 1975) Analysis of the cadmium content of 135 plankton samples from the northeast Pacific Ocean showed relatively low concentrations, ranging from 2 to 5 micro- grams of Cd/g, dry weight. One exception: from 10 to 20 ppm of Cd were detected in plankton collected off Baja California. -272- ------- 35-0047 GENERAL INFORMATION Anon A NEW PROCESS FOR RECOVERING ANTIMONY FROM ORE CONCENTRATES. . . Chem. Eng. 812 (25) : 18 (24 November 1975) Asarco Inc. will smelt its antimony ore concentrates in a reverberatory-type furnace in its $7-million El Paso refinery, which should be on stream at end of 1976, producing 5 tons Sb/day. Although Asarco is claiming a new process, available information indicates a conventional method. After the concentrates are smelted, a metallic mixture will be continuously tapped and granulated. The granules will be dissolved in an unnamed solvent and the Sb will be removed electrochemically. 35-0048 GENERAL INFORMATION Anon EFFECT OF TRACE METALS ON SEA LIONS PROBED Chem. Eng. News j>3_ (46): 34 (17 November 1975) Ocean pollutants seem to be having an effect on sea lions and other marine life. The premature pupping noticed in sea lions could be caused by an imbalance among mercury, selenium, and bromine in mother seals. A higher ratio of selenium to mercury in the affected seals and a lower level of bromine in their livers may be responsible. DDT concentrations are lower in crabs, mussels and other marine animals in the Pacific Ocean but remain high in fish living on the bottom near DDT-contaminated sediments, indicating potential hazards for some time yet from eating Dover sole or other contaminated bottom fish. DDT-caused fin rot has been observed in some fish. -273- ------- 35-0049 GENERAL INFORMATION Anon PCB SUBSTITUTE IS SAFE FOR ENVIRONMENT Chem. Eng. News 53_ (49): 7 (8 December 1975) Dow Chemical and McGraw Edison announce an environmentally safer PCB substitute, a butylated monochlorodiphenyl oxide. The new material, which is said to be more biodegradable, less bioconcentratable, and less toxic to fish than the PCB's, will be used in McGraw Edison's capacitors starting in mid-1976. 35-0050 GENERAL INFORMATION Anon LEAD BUILDUP IN HUMANS MAY RESULT FROM EXPOSURE TO AUTO EXHAUST EMISSIONS Chem. Week jj.7 (24) :_.59 (10 December 1975) Southwest Research Institute reports that lead levels in the blood were higher (over 40 micrograms/100 ml) in people living along a busy freeway than in those living in desert areas. Apparently, lead builds up in bodies of those exposed to high concentrations of automotive exhausts. -274- ------- 36-0001 ARSENIC Ember, Lois THE SPECTER OF CANCER Environ. Sci. Technol. 9^ (13): 1116-21 (December 1975) A review of programs underway and those needed to control and prevent the environmentally-caused diseases, which are considered increasing, is given. National Cancer Institute (NCI)'s analytical studies and list of 32 carcino- genic substances; EPA's interest; the Registry of Tumors in Lower Animals; the need for data and for information on the potential hazards of the more then 200,000 chemicals of commerce available, e.g., a National Environmental Banking System, NIOSH activities, and several problem areas are discussed. . Carcinogens such as arsenic, asbestos, benzene, benzidine, bis(chloromethyl) ether, cadmium oxide and sulfate, chromium compounds, nickel compounds, soot and tars, stilbestrol, naphthylamines, vinyl chloride, etc; are mentioned. -275- ------- 36-0002 ASBESTOS Rajbans, G.S. and Bragg, G.M. A STATISTICAL ANALYSIS OF ASBESTOS FIBER COUNTING IN THE LABORATORY AND INDUSTRIAL ENVIRONMENT Am. Ind. Hyg. Assoc., J...36. (12): 909-15 (1975) Measuring airborne asbestos fibers by the membrane filter method is relatively standardized and, according to the authors, sufficiently precise for industrial measurements. A detailed discussion of the reproducibility of standard fiber counts in the laboratory and four industrial plants is given. Standard deviations varied from 0,4 to 1.2f/ml for the results under field conditions and were approximately 0.2f/ml for the counts under ideal laboratory conditions. ASBESTOS See: 36-0001, Arsenic -276- ------- BENZIDINE See: 36-0001, Arsenic -277- ------- 36-0003 BORON Anon NEW METALLIC GLASSES HAVE BETTER HARDNESS AND MAGNETIC PROPERTIES Chem. Week 117. (25): 27 (December 1975) New ferrous metallic glasses from boron and iron with improved hardness and magnetic properties has been developed by the Materials Research center of Allied Chemical. These new alloys extend the temperature range in which the metallic glasses can be used. Potential applications include reinforcing elastomers and plastics, cutlery, corrosion-resistant cable, magnetic trans- former cores, magnetic shields, and tape recording heads. -278- ------- 36-0004 DIOXANE Anon OSHA COMPLETES TECHNICAL DRAFTS FOR 18 TOXIC SUBSTANCES Job Saf. Health Rep. 5. (23): 230 (17 November 1975) Dioxane is one of 18 toxic substances for which OSHA announced in the November 4, 1975 Federal Register that draft technical standards have been prepared and are available at OSHA, U.S. Dept. of Labor, Room N3620, 200 Constitution Ave. N.W., Washington, D.C. 20210 or at OSHA regional offices. -279- ------- 36-0005 FLAME RETARDANTS Orphanides, Gus G. FOREIGN TECHNOLOGY CONCERNING FIRE SAFETY' ASPECTS OF POLYMERIC MATERIALS Army Foreign Science & Technol. Center, Chariottesville Va. 1 April 1974, 49 p. Rep. NO. FSTC-CWnOl-110-74 This working paper presents the salient features of the foreign technology concerning fire safety aspects of polymeric materials. It describes the current state of foreign test methods, of foreign contributions to the understanding of fire dynamics, and of foreign organic fire resistant polymers. Particular attention is paid to developments in the United Kingdom. France, West Germany, Japan, and the Soviet Union. [Abstract in: Government Reports Announcements 75_(9): 147-8 (2 May 1975) 36-0006 FLAME RETARDANTS Anon CPSC WAIVES TESTING ON UM & M SLEEPWEAR Text. World 125 (12): 23 (December 1975) The all-cotton children's sleepwear fabric Wonderama of United Merchants and Mfrs. (U.M.&M.), finished with Fire Stop, a tetrakis hydromethyl phosphonium chloride (THPC)- derived finish, developed jointly by U.M.&M. and Cotton, Inc., received a Consumer Product Safety Commission (CPSC) waiver for multiple laundering testing requirements. A statistical study by U.M.&M. showed 99.31% conformance to CPSC standards following 50 home launderings and tumble dryings and was based on the previous 3.8 million yd. production. -280- ------- 36-0007 FLUOROCARBONS Symons, James M. et al NATIONAL ORGANICS RECONNAISSANCE SURVEY FOR HALOGENATED ORGANICS J. Am. Water Works Assoc. 67. (11): part 1 634-47 (November 1975) A National Organics Reconnaissance Survey (NORS) of 80 U.S. cities was conducted by EPA to determine the extent and presence of the four trihalomethanes — chloroform (trichloromethane), bromodichloromethane, dibromochloromethane, bromo- form (tribromomethane), 1,2-dichloroethane, and carbon tetrachloride in finished water and the effect raw-water source and water-treatment practices have on the formation of these compounds. Due to chlorination, the four trihalomethanes were found widely in U.S. drinking waters but were absent or present only in low concentrations in the raw waters tested. Carbon tetrachloride was not found in the raw water of 95% of the locations tested nor 87.5% of the finished waters tested with 3yg/l being the highest concentration found. Similarly 1,2-dichloro- ethane was not found in the raw water of 86% of the locations tested nor 67.5% of the finished waters tested with the highest concentration being 6yg/l. 36-0008 FLUOROCARBONS Bohning, D.E. et al EFFECTS OF FLUOROCARBONS 11 AND 12 ON TRACHEOBRONCHIAL PARTICLE DEPOSITION AND CLEARANCE IN DONKEYS Am. Ind. Hyg. Assoc., J. 36. (12): 902-8 (1975) After exposure to 1000 ppm fluorinated hydrocarbons (F-ll and F-12) separately and in a 50/50 mixture, alterations in tracheobronchial particle deposition or clearance in donkeys due to the fluorocarbon exposures were studied for the FC11 tests mean concentration was 1015 + 86 ppm and for the FC12 tests mean concentration was 1091 + 90 ppm. FC11 concentration was 487 + 46 ppm and FC12 concentration was 598 + 47 ppm for the mixture. Regional particle deposition or mucocilliary clearance rates in donkeys were not significantly altered by the exposure to FC-11 and FC-12 for up to six hours. Furthermore, 13 months of intermittent exposure to fluorocarbons, amounting to approximately 114 hours per animal, showed no cumulative residual effects on retention levels and clearance rates. -281- ------- 36-0009 FLUOROCARBONS Anon REPORT CITES EFFECTS OF FLUOROCARBON BAN Chem. Eng. News 53 (50): 8 (15 December 1975) A report entitled, "Preliminary Economic Impact Assessment of Possible Regulatory Action to Control Atmospheric Emissions of Selected Halocarbons", was prepared for EPA by Arthur D. Little, Inc. Ten primary industry sector affected in some way by any restriction on the production or emission of chlorofluorocarbons (F-ll, F-12 and F-22) and chlorocarbons (carbon tetratrachloride and methyl chloroform) are identified according to impact of regulation and implementation time. 36-0010 FLUOROCARBONS Evans, Joseph E. and Arnold, James T. MONITORING ORGANIC VAPORS Environ. Sci. Technol. £ (13): 1134-38 (December 1975) A portable mass spectrometer for field use in detecting organic vapors in the parts per billion (ppb) range has been developed for monitoring ambient and workplace air environments. The U.S. Army Environmental Hygiene Agency is already using the portable vapor detection system. A representative list of compounds being monitored on a daily basis includes chloroform, carbon tetra- chloride, bis-chloromethyl ether, dichloromonofluoromethane, formaldehyde, hexachloroethane, methyl isobutyl ketone, 8-naphthylamine, vinyl chloride, etc. Sensitivity for perchloroethylene in ambient air with the portable vapor detector has a lower detection limit of <0.1 ppb <0.1 ppb (> 0.7 Vgm3) at 164 MW. -282- ------- 36-0011 FLUOROCARBONS Anon MORE BAD NEWS FOR CHLOROFLUOROCARBONS Chem. Eng. News 53_ (51): 5 (22 December 1975) Balloon-borne measurements in the stratosphere over New Mexico show concentrations of chlorofluorocarbons CF-11 and CF-12 more than doubled since 1968 with concen- trations decreasing with increasing height. The concentration of F-ll at 18.5 km was 49 ppt compared to 20 ppt in 1968 and 160 ppt vs. 50 to 60 ppt F-12 in 1968. The average annual increase of halomethane levels averaged about 14% which corresponds to the increase of the world's fluorocarbon use. 36-0012 FLUOROCARBONS Anon A BILL RESTRICTING THE USE OF FLUOROCHLOROCARBON COMPOUNDS IN AEROSOL SPRAY CANS. . . Environ. Sci. Technol. £ (13): 1106 (December 1975) A New York state law has been passed and signed, directing the Commissioner of the Department of Environmental Conservation to promulgate labeling, restrictions and distribution rules and regulations concerning the use of fluorochlorocarbons in aerosol spray cans by January 1, 1976. Second only to Oregon in passing such a bill, N.Y. will implement restrictive use by January 1, 1978. -283- ------- HALOETHERS See: 36-0010, Fluorocarbons HALOETHERS See: 36-0001, Arsenic -284- ------- 36-0013 HYDRAZINE Anon POLLUTION THREATENS CLOSING OF FMC PLANT Chem. Eng. News 5J3 (50): 7 (15 December 1975) FMC uses dimethylnitrosamine (DMNA) as an intermediate in the production of unsymmetrical dimethylhydrazine, a rocket fuel for the Air Force. The office of Maryland's Secretary of Health and Mental Hygiene issued a violation notice to the FMC plant in regard to the release of detectable quantities of the toxic DMNA and ordered the plant be shut down until corrective measures were taken in its emission control system. Analytical measurements of the air surrounding the plant last summer and fall showed concentrations of DMNA ranging from 0.3 to 12 ppb. 36-0014 HYDRAZINE Anon FMC WILL SHUT DOWN THE PART OF ITS BALTIMORE PLANT CITED IN AIR POLLUTION CHARGES. Chem. Eng. News 53_ (51): 10 (22 December 1975) The Baltimore plant of FMC will stop making the rocket fuel unsymmetrical dimethylhydrazine no later than April 1 when present contracts expire. There are 23 employees involved in the closing. State and city charges of dimethyl- nitrosamine air pollution around the plant led to the charges although there has been no evidence of health damage. (See: CATS *36-0013, Hydrazine). -285- ------- ISOCYANATES See: 36-0023, Polyurethanes -286- ------- 36-0015 LIQUEFACTION AND GASIFICATION OF COAL Iowa State Univ. of Science and Technology, Ames. COAL PROCESSING BY ELECTROFLUIDICS Interim Rep. March/August 1974. January 1975, 133p. OCR-30-INT-3 Contract DI-14-01-0001-479 Summarized in the report are the results of research on the electrical character- istics of electrofluid reactors. Since the total resistance between electrodes placed in a fluidized bed includes both a contribution from the resistance of the bed and the electrode-to-bed contact resistance, measurements have been made of the total bed and contact resistances. Also reported are studies of arcing in the electrofluid reactor and a summary of methods for predicting the electrical properties of such systems. [Abstract in: Government Reports Announcements 75 (9): 58 (2 May 1975)J 36-0016 LIQUEFACTION AND GASIFICATION OF COAL Wyoming Univ., Laramie THE DIRECT PRODUCTION OF HYDROCARBONS FROM COAL-STEAM SYSTEMS Final Rep. November 1968-November 1973, January 1975, 87p. OCR-80-F Contract DI-14-01-0001-1196. Paper copy also available from GPO as C.1163.10:80 Experiments were carried out on the use of a multiple catalyst system consisting of potassium carbonate and a commercial nickel methanation catalyst for the direct production of methane from coal-steam reactions. This system combines the effects of these catalysts to produce in a single-step conversion a product gas consisting primarily of methane and carbon dioxide with a C02-free heating value as high as 850 Btu per SCF, Two of the apparent problems inherent with such a system were catalyst recovery and the loss of catalyst activity over prolonged periods of time at the conversion temperatures in the presence of the various reactants produced from the coal gasification. In conjunction with the latter problems, experiments were also performed on the influence of sulfur compounds produced during gasification upon catalyst life and activity. [Abstract in: Government Report Announcements 7_5_ (9): 59 (2 May 1975) -287- ------- 4,4'-METHYLENEBIS(2-CHLOROANILINE) See: .36-0023, Polyurethanes -288- ------- 36-0017 MODEL ECOSYSTEMS Lassiter, Ray R. MODELING THE DYNAMICS OF BIOLOGICAL AND CHEMICAL COMPONENTS OF AQUATIC ECOSYSTEMS Environmental Protection Agency, Athens, Ga. Southeast Environmental Res. Lab. May 1975, 62p. EPA/660/3-75-012 PB-241 987/7WJ PC$4.25/MF$2.25 To provide capability to model aquatic ecosystems or their sub-systems as needed for particular research goals, a modeling strategy was developed. Submodels of several processes common to aquatic ecosystems were developed or adapted from previously existing ones. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology (8 December 1975) 36-0018 MODEL ECOSYSTEMS National Ecological Res. Lab., Corvallis, Oreg. A CONCEPTUAL MODEL FOR THE MOVEMENT OF PESTICIDES THROUGH THE ENVIRONMENT: A CONTRIBUTION OF THE EPA ALTERNATIVE CHEMICALS PROGRAM. Final Rep.. James W. Gillet, James Hill, IV, Alfred W. Jarvinen, and W. Peter Schoor. December 1974, 89p. EPA/660/3-74/024 The report represents a conceptual model of the movement and disposition of pesticides in the environment. A multi-media model is built up from simple modules representing basic'processes and components of air, soil, and water. More specific models are exposited for the atmospheric/terrestrial, freshwater aquatic, and estuaring/marine environments. Ultimately systems analysis and mathematical simulation techniques can be employed to evaluate the fate of a specific chemical in a partcular environment. The conceptual model is thus a first step in organizing facts, assumptions, and hypotheses into a graphic and logical arm capable of exploitation in further experimentation of pesticide disposition and effects. A multi-media approach to disposition studies is made explicit even in the absence of a single all-media global model. [Abstract in: Government Reports Announcements 75 (9): 124 (2 May 1975)] -289- ------- 36-0019 MODEL ECOSYSTEMS Pielou, E.G. SPECIES ABUNDANCE PATTERNS Science 190 (4219):1086 (12 December 1975) The author reviews the mathematical aspects of ecological diversity in a given place and likely species-abundances. Methods for testing hypotheses against relevant data are also discussed. -290- ------- NAPHTHYLAMINES See: 36-0010, Fluorocarbons -291- ------- PERCHLOROETHYLENE See: 36-0010, Fluorocarbons -292- ------- 36-0020 PHTHALATES Liu, Benjamin Y.H. and Lee, K.W. AN AEROSOL GENERATOR OF HIGH STABILITY Am. Ind. Hyg. Assoc., J. 36_ (12): 861-65 (1975) A new approach, which uses a syringe pump to provide a constant liquid flow to an atomizer results in an aerosol generator of exceptionally high stability. In addition, Di-octyl phthalate (DOP) aerosols have also been produced by this syringe-pump atomizer used with a vaporizer and condenser. This system is simple, flexible, and easy to operate, making it a useful device for aerosol research. 36-0021 PHTHALATES Anon FMC HANGS OUT A LONG LINE OF PRICE HIKES Chem. Week 117 (26): 18 (24 December 1975.) As of January 1, FMC's Industrial Chemical Division will increase the price of diallyl phthalate in bulk, tank truck to 75c/lb; diallyl isophthalate to $1.45/lb., truck load; diallyl maleate in 480-lb. net weight drums to $1.30/lb. -293- ------- 36-0022 PHTHALATES Anon BASF WYANDOTTE UPPING PLASTICIZER CHEMICAL PRICES Chem. Week 117 (26): 18 (24 December 1975) The price of molten phthalic anhydride will increase 2/lb. to 26 f.o.b. South Kearny, N.J., as of January 1, according to BASF Wyandotte. Other plasticizer chemicals will raise their prices also, i.e., palatinol dioctyl phthalate to 27.50/lb and diisodecyl phthalate to 28. -294- ------- 36-0023 POLYURETHANES Pentz, William J. and Krawlec, Robert G. HYDROLYTIC STABILITY OF POLYURETHANE ELASTOMERS Rubber Age 107 (12): 39-43 (1975) This paper is the third in a continuing study of investigation to determine property differences of various polyurethane elastomers. The first two treated the low temperature properties of certain eleastomers while the third measures relative retention of elastomeric properties in a hydrolysis aging study of some polyethers and polyesters with several diisocyanate-curative systems. The selection of the appropriate diisocyanate-curative system for a polyether diol is important for resistance to hydrolytic degradation but much less so for a polyester diol. 36-0024 POLYURETHANES Frisch, K.C. and Reegen, S.L. ADVANCES IN URETHANE SCIENCE AND TECHNOLOGY Rubber Age 107 (12): 77-8 (1975) Eleven major reports on urethane chemistry and polymerization by leading authorities in the field are presented. Production processes and product application are included with foreign urethane techniques and an up-to-date bibliography. -295- ------- 36-0025 TRICHLOROETHYLENE Anon THE OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION (OSHA). Environ. Scl. Technol. 9_ (13): 1105 (December 1975) OSHA has proposed health standards for trichloroethylene. 36-0026 TRICHLOROETHYLENE Anon TRICHLOROETHYLENE INVESTIGATED. . . Am. Ind. Hyg. Assoc., J. 36. (12): A-7 (1975) The Manufacturing Chemists Association is administering a research study for Canadian Industries Ltd., Diamond Shamrock, Dow, Ethyl, Hooker and PPG, the focus of which will be trichloroethylene. Long term inhalation testing will be performed and the occupational aspects of the chemical's use in dry cleaning, degreasing, printing inks, coatings and adhesives will be studied. -296- ------- 36-0027 VINYL CHLORIDE Environmental Protection Agency, Washington, D.C. Office of Toxic Substances PRELIMINARY ASSESSMENT OF THE ENVIRONMENTAL PROBLEMS ASSOCIATED WITH VINYL CHLORIDE AND POLYVINYL CHLORIDE Interim Rep. September 1974, 106p. EPA/560/4-74-001 PB-239 110/OGA The report summarizes the activities and findings of a task force to assess the character and extent of the problems associated with the production, distribution, use, and disposal of vinyl chloride and polyvinyl chloride. The first Section discusses the nature and magnitude of problems. The second discusses previous and planned activities within the Federal Government of particular significance and the role of industry. The report concludes with some specific recommendations. [Abstract in: Government Reports Announcements 75 (9): 126-7 (2 May 1975)] 36-0028 VINYL CHLORIDE Cuddeback, John E. et al PERFORMANCE OF CHARCOAL TUBES IN DETERMINATION OF VINYL CHLORIDE Environ. Sci. Technol. £ (13): 1168-71 (December 1975) An examination of the performance parameters of the charcoal tube absorption method as an analytical sampling device for airborne vinyl chloride was under- taken and is described in this article. The capacity of a 100 mg portion of activated charcoal in a sampling tube is shown to be at least 65 yg. The authors point out that this method is adequate for concentrations of 1-50 ppm or more but as the concentrations of vinyl chloride monomer (VCM) decrease, scatter in the data and sample losses greatly affect analytical accuracy. The methodology by which a 90% recovery of vinyl chloride was obtained even following a two week sample storage is also described. -297- ------- 36-0029 VINYL CHLORIDE Anon GOODRICH MEETS VINYL CHLORIDE SAFETY RULES Chem. Eng. News .5_3 (50): 14 (15 December 1975) B.F. Goodrich is the number one PVC producer with about 20% of the U.S. market of 3.5 billion Ib. this year. Not only are the company's five PVC plants operating well within OSHA rules, but the company's President states, "We are now supplying PVC resins and compounds with such minute content of residual vinyl chloride that the possibility of vinyl chloride exposure from their processing or use is virtually eliminated". 36-0030 VINYL CHLORIDE Anon NEW VCM PLANT PLANNED Chem. Week 117 (25): 17 (17 December 1975) Diamond Shamrock has plans to build and operate a 1 billion-lbs/year vinyl chloride monomer (PVC) plant at its LaPorte, Texas complex, thereby giving the company a fully integrated production complex ranging from chlorine to PVC. The Texas Air Control Board (TACE) has been asked to grant a permit for the project. Tenneco Chemicals has requested permission to expand its new 250-million Ibs/year capacity plant at Pasadena, Texas. -298- ------- 36-0031 VINYL CHLORIDE Anon CLEARING THE AIR Chem. Week 117 (26): 10 (24 December 1975) EPA's proposed standards for vinyl chloride are expected to reduce plant emissions by 90% at a cost of $198 million to meet the standards for existing facilities and an operating cost of $70 million/year. This EPA program would require manufacturers of vinyl chloride, PVC and ethylene dichloride to reduce stack and "fugitive" source emissions to 10 ppm and install the best available technology appropriately in the production process with controls in place 90 days after final ruling. The EPA emphasizes a potential cancer risk to 4.6 million persons living within five miles of the 56 plants which emit an estimated 100 million kilograms/yr. VINYL CHLORIDE See: 36-0001, Arsenic -299- ------- VINYL CHLORIDE See: 36-0010, Fluorocarbons -300- ------- NITROSAMINES See: 36-0014 NITROSAMINES See: 36-0013 -3C1- ------- 36-0032 GENERAL INFORMATION Zapp, J.A., Jr. INHALATION TOXICITY OF HEXAMETHYLPHOSPHORAMIDE Am. Ind. Hyg. Assoc., J. 36. (12): 916 (1975) A summary report from DuPont highlights concern over increasing use of hexamethyl- phosphoramide (HMPA) as a solvent with exceptional power, as an effective chemist- erilant for a number of insect pests, etc. Although acute toxicity of HMPA for experimental animals is low to moderate by ingestion, inhalation, skin absorption and as a skin irritant, chronic toxicity of HMPA is more severe. Experimental study of HMPA and nasal tumors in rats carried out by DuPont is described briefly The author concludes that "There appears to be no doubt that this rare form of cancer has been produced in rats by inhalation exposure to HMPA in a concentration as low as 400 ppb (analytical) in a period of about eight months." Precautions appropriate to a potential carcinogen are urged. 36-0033 GENERAL INFORMATION Lloyd, William J. HEXAMETHYLPHOSPHORIC TRIAMIDE (HMPA) Am. Ind. Hyg. Assoc., J. 36. (12): 917 (1975) As a result of the information reported to the National Institute for Occupational Safety and Health (NIOSH) by DuPont (see: CATS 36-0032) regarding potential risk of human exposure to hexamethylphosphoric triamide (HMPA), NIOSH is advising the occupational health community of these findings. This paper provides background material on HMPA prepared by the Office of Occupational Health Surveillance and Biometrics, NIOSH, for information purposes. -302- ------- 36-0034 GENERAL INFORMATION Anon GE ADMITS 65 EMPLOYEES SUFFERED FROM FROM PCB EXPOSURE OVER 15-YEAR PERIOD Job Saf. Health Rep. 5_ (23): 227 (17 November 1975) According to GE spokesmen, 49 of about 1800 employees working in areas exposed to PCBs complained of allergic dermatitis and an additional 16 reported nausea, dizziness, eye and/or nasal irritation, asthmatic bronchitis and fungus. Testimony was held at a public hearing in Albany, N.Y. as a result of a complaint filed in the N.Y. Dept. of Environmental Conservation that GE violated state water quality standards by dumping PCBs into the Hudson River from its plants in Ft. Edward and Hudson Falls, N.Y., during the manufacture of capacitors. 36-0035 GENERAL INFORMATION Anon CHEMICAL POLLUTANTS: POLYCHLORINATED BIPHENYLS STILL A THREAT Science 190 (4220) 1189 (19 December 1975) Despite voluntary controls by manufacturers and users of polychlorinated biphenyls, the total amount of PCB's in the environment appears to have increased substantially. EPA states that despite the hazards of PCB's, until the Toxic Substances Control Act is passed, EPA has no power to restrict or prevent production, etc. -303- ------- REGULATIONS AND STANDARDS See: 36-0031, Vinyl chloride -304- ------- 37-0001 ACRYLONITRILE (Production) Kiefer, David M. RISING DEMAND WILL SPUR SALES AND EARNINGS Chem. Eng. News 53_ (51): 26-7, 30 (22 December 1975) The 13 to 15% drop in output of industrial chemicals and synthetics in 1975, compared to 1974, should take a healthy upswing in 1976, if the general economy continues strong. Among organic chemicals, acrylonitrile production, which dropped to 1,25 million Ib in 1975 from about 1.4 million Ib in 1974, is expected to rise to 1.6 million Ib in 1976; perchloroethylene should rise to 800,000 Ib in 1976, having dropped to 680,000 Ib in 1975 from 733,000 in 1974. Among plastics, PVC production, which dropped from 4.85 million Ib in 1974 to 3.75 million Ib in 1975, is expected to reach 5.45 million Ib in 1976. 37-0002 ACRYLONITRILE Anon COATERS CHECK ON CHEMICAL LINE-UP Can. Chem. Process. 5£ (11): 30-2 (1975) Canadian papermakers are taking a new look at coating chemicals. Among possibilities: use of asbestos fiber as a filler, despite current concern of asbestos hazards, and use of Dow's Saran microspheres, which are copolymers of vinylidene chloride and acrylonitrile, as substitutes for titanium dioxide. -305- ------- 37-0003 ARSENIC Johnson, David L. and Braman, Robert S. ALKYL- AND INORGANIC ARSENIC IN AIR SAMPLES Chemosphere 4_ (6): 333-8 (December 1975) Tests conducted in the Tampa Bay, Florida, area showed the presence of inorganic arsenic, dimethylarsine and trimethylarsine, but no methylarsine, in the air. The sources of the various forms of arsenic in the air are probably non-biological processes as well as biological processes, It is possible that vapor phase alkyl-arsenic/particle reactions are a natural mechanism for arsenic enrichment in aerosol samples. -306- ------- 37-0004 ASBESTOS Anon ASBESTOS/MEASURING TECHNIQUE Environ. Rep. 6. (15): 116 (9 December 1975) An X-ray diffraction technique under development by the U.S. Naval Research Laboratory may be cheaper and faster than electron microscopy as a means of measuring submicrogram amounts of asbestos in air or water. 37-0005 ASBESTOS Anon AIRBORNE PARTICLE SAMPLER Environ. Rep. 6. (16): 125 (19 December 1975) A prototype device developed at Stockholm University detects potentially harmful particles, such as lead and asbestos, in air and traces their fluctuations for seven days. -307- ------- 37-0006 ASBESTOS Lavappa, K.S. et al CYTOGENIC STUDIES ON CHRYSOTILE ASBESTOS Environ. Res. 10_ (2): 165-73 (1975) For in vivo tests, certain monkeys were fed 100 or 500 mg/kg of chrysotile in cookies, while others were injected twice i.p. or gavaged twice with 0.2, 2, 20, and 200 mg/kg chrysotile. The in vitro tests were performed using hamster embryo cultures. No noticeable chromosome aberrations were observed in the bone marrow cells of the monkeys used in the in vivo tests, but a dose-related increase in the incidence of chromatid gaps and breaks occurred in the embryo cells used in the in vitro tests. 37-0007 ASBESTOS Morgan, A. et al STUDIES ON THE DEPOSITION OF INHALED FIBROUS MATERIAL IN THE RESPIRATORY TRACT OF THE RAT AND ITS SUBSEQUENT CLEARANCE USING RADIOACTIVE TRACER TECHNIQUES Environ. Res. 10 (2): 196-207 (1975) In accordance with the recommendation of the Advisory Committee on Asbestos Cancers that more should be learned about the deposit and retention of inhaled asbestos fibers, rats were exposed to the UICC standard reference samples for 30 minutes. From 31 to 68% of the inhaled fibers were deposited and about 17% was retained in the lower respiratory tract. From autoradiographs of lung sections it appeared that fibers were located in the conducting airways, especially at bifurcations, and were distributed fairly uniformly throughout the alveolated regions. -308- ------- 37-0008 ASBESTOS Amacher, D.E. et al THE DOSE-DEPENDENT EFFECTS OF INGESTED CHRYSOTILE ON DNA SYNTHESIS IN THE GASTROINTESTINAL TRACT, LIVER, AND PANCREAS OF THE RAT Environ. Res. 10_ (2): 208-16 (1975) Because asbestos fibers have been detected in drinking water and asbestiform fibers in certain foods and beverages, adult rats were given from 0.5 to 100 mg/kg chrysotile and later examination indicated a limited dose-dependent effect on [%]thymidine incorporation in the gastrointestinal tract. Chrysotile in the 5-50 mg/kg dose range most effectively enhanced [3H]thymidine incorpora- tion in the stomach, duodenum, and jejunum. Apparently, chrysotile can be physicochemically altered by gastric acid and this may be a factor on the effects of chrysotile on DNA synthesis. 37-0009 ASBESTOS Bruckman, Leonard and Rubino, Robert A. ASBESTOS: RATIONALE BEHIND A PROPOSED AIR QUALITY STANDARD J. Air Pollut. Control Assoc. 25. (12): 1207-15 (1975) The authors propose an ambient air quality asbestos standard of 30 nanograms/ cu m, based on a 30-day average sample and discuss their reasons briefly. On pp. 1212-4, L.A. Plumlee indicates that for certain reasons, including the fact that the authors base their standards only on the risk of mesothelioma the proposed standards are not supportable. Bruckman and Rubino refute Plumlee's charges on pp. 1214-5. -309- ------- ASBESTOS See: 37-0002, Acrylonitrile -310- ------- 37-0010 FLUOROCARBONS Paulet G. et al FLUOROCARBONS AND GENERAL METABOLISM IN THE RAT, RABBIT, AND DOG Toxicol. Appl. Pharmacol. J34 (2): 197-203 (November 1975) Rabbits and dogs inhaled monofluorotrichloromethane (FC 11) and difluorodichloro- methane (FC 12) for one 20-minute period. Exposures were as follows: FC 11: 5%, FC 12: 20%, and FC 11/FC 12 (10/90): 20% or 50%. In another series of tests, rats and rabbits inhaled the fluorocarbons for two 1-hr periods/day for 15 days. In both series of tests, all mixtures contained 20% oxygen. Significant metabolic effects were noted only with FC 11 at 5%, which caused a decrease in oxygen uptake, hyperglycemia and hyperlactacidemia, and several other effects apparently due to a slowing down of cellular oxidation. 37-0011 FLUOROCARBONS Paulet G. et al FATE OF FLUOROCARBONS IN THE DOG AND RABBIT AFTER INHALATION Toxicol. Appl. Pharmacol. 3^_ (2): 204-13 (November 1975) To determine the distribution and fate in the body of inhaled fluorocarbons, dogs and rabbits were exposed to monofluorotrichloromethane (FC 11) in concen- trations of 2.5 and 5%, to dichlorodifluoromethane (FC 12) in concentrations of 20 and 50%, and to a 10/90 mixture of FC 11/FC 12 in concentrations of 25 and 90%, Both compounds diffused rapidly into the blood, the cerebrospinal fluid (CSF), the urine and the bile in concentrations governed by the concentration inhaled. The gases were completely eliminated from the body 20-50 minutes after fresh air was inhaled. Elimination was primarily via the pulmonary system rather than via the bile or urine. -311- ------- 37-0012 FLUOROCARBONS Zafonte, L. et al BACKGROUND AND VERTICAL ATMOSPHERIC MEASUREMENTS OF FLUOROCARBON-11 AND FLUOROCARBON-12 OVER SOUTHERN CALIFORNIA Atmos. Environ. £ (11): 1007-9 (1975) Background concentrations of FC-11 (CC^F) and FC-12 (CC12F2) in air collected at ground level to 22,000 ft over the Southern California area were 0.060 and 0.090 ppb, respectively. Ozone concentrations were measured at the same time. It appears that FC-11 and FC-12 can serve as polluted air tracers below the inversion layer. 37-0013 FLUOROCARBONS Grimsrud, E.P. and Rasmussen, R.A. THE ANALYSIS OF CHLOROFLUOROCARBONS IN THE TROPOSPHERE BY GAS CHROMATOGRAPHY- MASS SPECTROMETRY Atmos. Environ. 9_ (11): 1010-13 (1975) A gas chromotograph linked directly to a mass spectrometer was more sensitive than the electron capture detector in measuring CF_ Cl, particularly, and CFC1- in rural atmospheres, according to tests conducted in the Pacific Northwest served. The technique permits detection of 5 ppt in 20 cm^ air samples. Results showed concentrations of about 230 + 8 ppt of CF2 C12 and 128 + 5 ppt of CFC13 in several areas, with little variations in these concentrations in ambient air and up to 12,000 ft above sea level. -312- ------- 37-0014 FLUOROCARBONS Grimsrud, E.P. and Rasmussen, R.A. SURVEY AND ANALYSIS OF HALOCARBONS IN THE ATMOSPHERE BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY Atmos. Environ. 9_ (11): 1014-17 (1975) The use of gas chromatography linked with mass spectrometry to determine the presence of 19 simple halocarbons in the atmosphere of our rural Northwest as part of a study to define the roles of chlorofluorocarbons and chlorocarbons as carriers of chlorine in the troposphere. Methyl chloride, previously unreported, was detected in high concentration, 530 + 30 ppt. Tetrachloroethylene (perchloroethylene) was found in concentra- tions of 20 +10, but trichloroethylene was not found in detectable amounts. Relatively high concentrations of chlorofluorocarbons were detected. 37-0015 FLUOROCARBONS Rowland, F.S. et al NATURAL HALOCARBONS IN AIR AND SEA Nature 258 (5537): 775-6 (25 December 1975) The authors refute the theory of J.E. Lovelock [Nature, 256, 193 (1975)] about the concentration and stability of C^Cl in the stratosphere, arguing that the methyl chloride has, a short atmospheric life-time (compared to CCl^F) and that CH3C1 should be now present at a steady level. Lovelock responds that he may be mistaken about the rapidity of destruction of CH3C1 in the stratosphere but argues that CH3C1, which has been measured only during the last 10 months, may vary in its concentration. -313- ------- 37-0016 FLUOROCARBONS Hanst, Philip L. et al INFRARED MEASUREMENT OF FLUOROCARBONS, CARBON TETRACHLORIDE, CARBONYL SULFIDE, AND OTHER ATMOSPHERIC TRACE GASES J. Air Pollut. Control Assoc. 25. (12): 1220-6 (1975) For proper measurement of air pollutants by infrared absorption spectroscopy, the pollutants should be concentrated by separating them from nitrogen, oxygen, water vapor, and even from CO,,. In this study, cryogenic condensation followed by distillation, combined with a chemical step to absorb C02» was used to concentrate the pollutants. Measured at 3 locations, background concentrations of trichlorofluoromethane (F-ll) ranged from 1.2 x 10"^ atm to 7.4 x 10"1" atm, confirming that F-ll is now emitted more than carbon tetra- chloride as a result of human activities. Dichlorodifluoromethane (F-12) and perchloroethylene concentrations are also discussed. 37-0017 FLUOROCARBONS Anon AEROSOL BAN REJECTED Chem. Week 118 (1): 14 (7 January 1976) Basing its decision on the fact that the ozone theory has not yet been proved, the Consumer Product Safety Commission rejected a petition by Los Angeles to ban fluorocarbon-propelled aerosol products. Earlier, CPSC rejected a similar petition by the Natural Resources Defense Council, and probably will not act on a second NRDC petition until NAS publishes the results of its study on this topic in April 1976. On the other hand, EPA wants pesticide makers to use alternatives to fluorocarbons in aerosol pesticides. -314- ------- 37-0018 FLUOROCARBONS Anon NEW RATE DATA FOR KEY OZONE DEPLETION REACTION J. Air Pollut. Control Assoc. 25. (12): 1260, 78-9 (1975) The findings of Drs. Michael J. Kurylo and Walter Braun of NBS that at 25°C the rate of reaction between chlorine and ozone is only 60% of the value used by Rowland et al to predict stratospheric ozone depletion (See CATS *33-0010) have been verified by studies at the "University of Maryland, the University of Pittsburgh, and Queen Mary College, London, England. These new data predict ozone depletion by chlorine at a slower rate than predicted by Rowland et al, who had to rely on data at room temperature, which is much higher than stratospheric temperatures. 37-0019 FLUOROCARBONS Anon ALSO AT THE MEXICO CITY MEETING, FLUOROCARBONS CAME UNDER FIRE. . . Chem. Eng. 82. (27) : 20 (22 December 1975) Scientists at the Univ. of California (Irvine) have refined their original ozone-depletion theory, which was based on room-temperature data, by measuring F-12 UV light absorption at about -39°C, a temperature closer to that of the stratosphere. At the lower temperature, absorption is slower but the scientists claim that although chlorine thus would have a longer time to react with ozone there will be but slight change in the ozone-chlorine reaction. Closing another loophole in the original theory, NASA scientists report that only one HC1 molecule out of tens of millions would be destroyed, thus ruling out a natural ammonia-HCl sink for the harmful chlorine. -315- ------- 37-0020 HALOETHERS Chang, Louis W. et al ULTRASTRUCTURAL STUDIES ON THE PATHOLOGICAL CHANGES IN THE NEONATAL KIDNEY FOLLOWING IN UTERO EXPOSURE TO HALOTHANE Environ. Res. 10 (2): 174-89 (1975) Pathological renal lesions induced in pregnant rats exposed to 10 ppm halothane all through pregnancy strongly suggest that halothane is a potential occupational hazard especially for pregnant operating room personnel. Operating room personnel are often exposed to 10 ppm halothane for 8 hr/day and 5 days/wk. -316- ------- 37-0021 HEXACHLOROBENZENE Yang, Raymond S.H. et al CHROMATOGRAPHIC METHODS FOR THE ANALYSIS OF HEXACHLOROBENZENE AND POSSIBLE METABOLITES IN MONKEY FECAL SAMPLES J. Assoc. Off. Anal. Chem. 58. (6): 1197-1201 (1975) Thin layer chromatography, high-pressure liquid chromatography, and gas-liquid chromatography proved effective techniques for the separation and identification of hexachlorobenzene and possible metabolites, such as pentachlorobenzene and pentachlorophenol, from monkey feces. 37-0022 HEXACHLOROBENZENE Hill, Kenneth R. IUPAC COMMISSION ON TERMINAL RESIDUES J. Assoc. Off. Anal. Chem. 58. (6): 1256-9 (1975) Five references published in 1972 and 1973 indicate that hexachlorobenzene is metabolized by cows, sheep, and chickens whose feed contains HCB residues. -317- ------- 37-0023 HYDBAZINE Anon FUEL PLANT CLOSING Chem. Week 117 (26): 10 (24 December 1975) As a result of findings indicating the presence of the suspect carcinogen, dimethylnitrosamine, in the air near its Baltimore plant producing unsym- metrical dimethylhydrazine, FMC will stop producing the rocket fuel by 1 April 1976. -318- ------- 37-0024 MODEL ECOSYSTEMS Varo, P., Symposium Editor SELECTED SPECIALLY INVITED LECTURES PRESENTED AT THE THIRD INTERNATIONAL CONGRESS OF PESTICIDE CHEMISTRY AND THE SYMPOSIUM ON DISPERSION DYNAMICS OF POLLUTANTS IN THE ENVIRONMENT, held in Helsinki, Finland, 3-9 July 1974 Pure Appl. Chem. 42 (1-2): 1-299 (1975) The 22 papers presented cover topics ranging from "Factors that affect the persistence of pesticides in plants and soils" (C.A. Edwards, pp. 39-56) to "The future of the development of pesticides by industry" (E.Knusli, pp. 77-87). More specific topics include: "Transport mechanisms for pesticides in the atmos- phere" (C.E. Junge, pp. 95-104); ... in water (A.M. Aitsam, pp. 105-11); ... in soil (E.P. Lichtenstein, pp. 113-8); "Mathematical models in ecochemistry" (J.Robinson, pp. 139-53); "Organochlorine compounds in the general population of the seventies and some of their biological effects (in man and animals)" (M. Wasserman et al, pp. 189-208); and "Mutagenic, carcinogenic, and teratogenic effects of pollutants in respect to man" (F. Coulston and J.H. Wills, pp. 209-22) -319- ------- 37-0025 OPTICAL BRIGHTENERS Ganz, Charles R. et al REMOVAL OF DETERGENT FLUORESCENT WHITENING AGENTS FROM WASTEWATER J. Water Pollut. Control Fed. k]_ (12): 2834-49 (December 1975) A series of studies on the removal of four ionic stilbene and three nonionic detergent fluorescent whitening agents from wastewater influent showed adsorption to the wastewater sludge to be the most likely route of FWA removal. From an experiment in which the FWA's in a sludge wet cake sample were exposed to ambient weather conditions, it appears that the FWA's in sludge do not readily enter groundwater supplies via rainwater leaching. -320- ------- PERCHLOROETHYLENE See: 37-0001, Acrylonitrile See: 37-0014, Fluorocarbons See: . 37-0016, Fluorocarbons -321- ------- 37-0026 PHTHALATES Anon PHTHALATES IN OCEAN WATER Environ. Rep. 6^ (16): 126 (19 December 1975) A study by the College of Science, Texas A & M University, indicates the presence of phthalates in parts per trillion in water and parts per billion in various organisms in Gulf of Mexico samples. -322- ------- 37-0027 POLYURETHANES (Uses) Anon SLICK IDEA FOR OIL-SPILL CLEANUP Chem. .Week_U7 (26) : 11 (24 December 1975) Urethane foam chips tested by the Navy for oil-spill cleanups reach the saturation point in six seconds but can be recycled in only 60 seconds for re-use up to 50 times. POLYURETHANES See also: 37-0037, Nitrosamines -323- ------- 37-0028 TRICHLOROETHYLENE Anon HEALTH PROBLEMS THAT MIGHT BE ASSOCIATED WITH TRICHLOROETHYLENE. . . Chem. Eng. News 54_ (1): 15 (5 January 1976) The MCA is administering a $400,000 industry-sponsored project by Industrial Bio-Test Laboratories to study the potential health hazards of trichloro- ethylene, which has been reported to cause liver cancer and other tumors in mice. TRICHLOROETHYLENE See: 37-0014, Fluorocarbons -324- ------- 37-0029 VINYL CHLORIDE Anon VC EMISSIONS Environ. Rep. £ (16): 123 (19 December 1975) R. Harding, Jr., of the Society of Plastics Industry views as a "precautionary step" the proposal by EPA to classify VC as a hazardous air pollutant, claiming that those living near VC or PVC plants do not run health risks. Harding, however, feels that emission controls are in the public interest. EPA's proposed standards to reduce VC emissions 90% are based on evidence showing VC to be carcinogenic. If put into effect, four small PVC plants might be forced to close. 37-0030 VINYL CHLORIDE Edmonds, Larry D. et al CONGENITAL MALFORMATIONS AND VINYL CHLORIDE Lancet 2 (7944): 1098 (29 November 1975) Further analysis of the birth-defects attributed to vinyl chloride in infants born in Pennsylvania and Ohio showed that parents of these children did not work at the PVC polymetization plants, but that two of the fathers of the controls worked at one of the plants, and more mothers of the control babies lived nearer the plants than did mothers of the affected babies. Only the Ohio Dept. of Health study has associated the birth defects with VC. A follow-up study in Painesville, Ohio, did not associate a noted moderate increase in CNS malformations with VC exposure. -325- ------- 37-0031 VINYL CHLORIDE Duck, B.W. et al MORTALITY STUDY OF WORKERS IN A POLYVINYL-CHLORIDE PRODUCTION PLANT Lancet 2^ (7946): 1197-9 (13 December 1975) No significant excess of total mortality and no liver cancers were found in an age-standardized mortality rate study of 2100 male workers exposed to vinyl chloride for as long as 27 years in a factory in South Wales. The factory has polymerized vinyl chloride since 1948 and produced VC monomer on the site until 1968. 37-0032 VINYL CHLORIDE Schaffner, Robert M. and Lombardo, Pasquale THE FOOD AND DRUG ADMINISTRATION AND THE VINYL CHLORIDE PROBLEM — AN OVERVIEW J. Air Pollut. Control Assoc. .5J5 (6): 1211-13 (1975) The mid-1974 disclosure of angiosarcomas associated with PVC fabrication and the findings that lab animals incur cancer from chronic inhalation of VC has led the FDA to study its potential effects when ingested. These studies, reviewed here briefly, have not yet shown VC taken orally to cause angio- sarcoma or other malignant tumors. -326- ------- 37-0033 VINYL CHLORIDE Breder, Charles V. et al GAS-LIQUID CHROMATOGRAPHIC DETERMINATION OF VINYL CHLORIDE IN VINYL CHLORIDE POLYMERS, FOOD-SIMULATING SOLVENTS, AND OTHER SAMPLES J. Assoc. Off. Anal. Chem. _58 (6): 1214-20 (1975) Gas-liquid chromatography can detect 0.05 ppm VC in solution or 1 pptn VC in PVC according to described tests using PVC, vegetable oils, mouthwashes, blood anticoagulant solutions and other solvents. 37-0034 VINYL CHLORIDE Anon RUSSIAN VCM CAPACITY BUILDUP IS UNDER WAY Chem. Week 118 (1): 28 (7 January 1976) Now that its 250,000-metric-tons/yr Kalush in the Ukraine plant is on-stream, Russia has doubled its VCM capacity. Additional capacity is planned for 1978 when a $40-million, 270,000-tnetric-ton/yr VCM plant on order from Germany will be ready. -327- ------- VINYL CHLORIDE See: 37-0001, Acrylonitrile -328- ------- 37-0035 VINYLIDENE CHLORIDE Anon LIVER PROBLEMS STUDIED Chem. Week 118 (1): 13 (7 January 1976) Twenty-seven employees of BASF Wyandotte's South Kearny, N.J., plant were found to have liver abnormalities; 10 of these have had biopsies. The BASF program involving medical examinations for 50 workers may be continued for the other 250 employees. Although the United Rubber Workers earlier suggested that the liver problems were associated with vinylidene chloride, they now state that the cause has not yet been determined. OSHA asked NIOSH to help BASF in solving the problem. Additionally, MCA is studying vinylidene chloride, which has been implicated as a potential carcinogen by Italian researchers. VINYLIDENE CHLORIDE See: 37-0002, Acrylonitrile -329- ------- 37-0036 NITROSAMINES Laishes, B.A. et al ORGAN-SPECIFIC DNA DAMAGE INDUCED IN MICE BY THE ORGANOTROPIC CARCINOGENS 4-NITROQUINOLINE 1-OXIDE AND DIMETHYLNITROSAMINE (38938) Proc. Soc. Exp. Biol. Med. 149; 978-82 (1975) The chemical carcinogen, dimethyInitrosamine (DMN) induced DNA damage in the lung, kidney, and liver of mice injected with 1 mg and 8 mg/kg. The greatest DNA fragmentation occurred in the liver. Another carcinogen, 4-nitroquinoline 1-oxide had its greatest effect on the lung, followed by the kidney and the liver. The non-carcinogen, 4-aminoquinoline 1-oxide, did not induce any DNA damage. To assess the levels of DNA tissue damage the biophysical technique of velocity sedimentation of DNA, in alkaline sucrose gradients, was used. 37-0037 NITROSAMINES DiPaolo, Joseph A. and Cuddy, Rosemary SUMMARY OF THE PROCEEDINGS OF THE JOINT U.S.S.R. SYMPOSIUM ON MAMMALIAN SOMATIC CELL GENETICS RELATED TO NEOPLASIA J. Nat. Cancer Inst. Jx5 (6): 1369-71 (December 1975) A 2-day symposium on the title topic held in Moscow on 17-20 June 1974 included several papers concerned with mutagenesis in relation to carcino- genesis involving such chemicals as urethan, dimethylnitrosamine (DMN), diethyInitrosamine (DENA), and methylnitrosourea (MNU). This summary indicates that DMN and DENA caused pulmonary tumors in hamsters, but that urethan did not. The carcinogens induced chromosome aberrations when tested on rat kidney, lung, or mixed tissues. -330- ------- 37-0038 NITROSAMINES Tabuchl, Yoshiki et al MUCOSAL DAMAGE INDUCED BY VARIOUS GASTRIC CARCINOGENS IN THE GLANDULAR STOMACH OF THE RAT J. Nat. Cancer Inst. 55. (6): 1395-1401 (December 1975) N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) was previously shown to injure the glandular mucosa of the rat stomach, a result that can lead to gastric carcinogenesis. In this study rats were given one or more intragastric doses of MNNG (100 mg/kg body weight) and the induced erosion was studied histologically, histochemically, and ultramicroscopically and compared with the erosion process caused by other gastric carcinogens and certain other chemicals. Mucosal damage from MNNG started in the surface epithelium within an hour; erosion occurred as soon as 2 days after 3 successive doses of MNNG. Fatty change in the mucosal cells was the first transformation noted. Other gastric carcinogens tested produced similar results. 37-0039 NITROSAMINES Lilly, Lorna J. et al CHROMOSOME ABERRATIONS INDUCED IN RAT LYMPHOCYTES BY N-NITROSO COMPOUNDS AS A POSSIBLE BASIS FOR CARCINOGEN SCREENING Nature 258 (5536): 611-2 (18 December 1975) Chromosome aberrations in rat lymphocyte cultures treated with dimethyl- nitrosamine (DMN) in vitTO were not significantly different from control cultures. However, a significant increase in aberrations was noted in cultured lymphocytes from rats injected i.p. with 30 mg/kg body weight of DMN, 6 hr before being killed. Apparently, active metabolites from DMN are stable enough to pass from their sites of formation in such organs as the liver, which are capable of activating the compound, and to reach the nuclei of the circulating lymphocytes. -331- ------- NITROSAMINES See; 37-0023, Hydrazine -332- ------- 37-0040 GENERAL INFORMATION Anon END OF LINE FOR KEPONE Chem. Week 117 (26): 10(24 December 1975) EPA recommends a long-term health study of residents of Hopewell, Va. , now that EPA investigations have shown that from March 1974-April 1975 Kepone levels of 0.2-50 mg/cu m were detected in air 200 yards from the Life Science Products plant (which was closed in August 1975) and levels of 0.1-20 nano- grams/cu m were found in the air of South Richmond, 16 miles from Hopewell. Other findings: 200-600 ppm Kepone in sludge near the company's sewage treat- ment plant; levels of 0.1-10 ppm Kepone in waste water at the sewage treat- ment plant; 0.1-4 ppb in James River water; and 0.1-20 ppm in fish and shell- fish in the James River. 37-0041 GENERAL INFORMATION Anon KEPONE STUDY WIDENS Chem. Week 118 (1): 13 (7 January 1976) Although Life Science Products, Hopewell, Va., no longer makes Kepone, detectable levels of the pesticide have been found in the air and water for some distance around Hopewell, prompting a request for a federal grand jury investigation of the company's operations. Meanwhile, former Life Science employees, who are suing that company, are now also seeking redress from Allied and Hooker Chemicals and Plastics. They claim that Allied failed to make known that Kepone was very toxic to humans, did not properly label containers, and neglected to provide informa- tion on an antidote. -333- ------- 37-0042 GENERAL INFORMATION Anon CHLORINE CAR EXPLODES Chem. Week 117 (26): 10 (24 December 1975) Four workers were killed and 86 were injured or treated for fume inhalation, when a 30-ton rail tank car containing recovered chlorine exploded recently at the Niagara Falls plant of Hooker Chemical and Plastics. The resulting fumes traveled to a nearby residential area and a shopping center. Cause of the explosion was not determined. The chlorine, recovered from Hooker's by-product gases was being stored for future use in the company's 400 tons/day chlorine plant that employs about 1500 workers. 37-0043 GENERAL INFORMATION Bock, Fred G. et al COCARCINOGENIC ACTIVITY OF PEROXY COMPOUNDS J. Nat. Cancer Inst. _55_ (6): 1359-61 (December 1975) Peracetic acid (PAA), used in several ways as an industrial chemical, as a lab cold-temperature sterilizing agent, and suggested (in dilute solution) as a preoperative sterilizing agent for surgeons' hands, was found to be a potent tumor promoter and a weak complete skin carcinogen in tests on mice. Although humans are not so sensitive to contact carcinogens as are mice, the possibility is raised that tumors in man might result from the action of other carcinogens with PAA, especially in pulmonary exposure. -334- ------- 37-0044 GENERAL INFORMATION Anon PEREGRINE FALCON Environ. Rep. 6. (15): 117 (9 December 1975) The inadequate reproductive rate of the peregrine falcon in northwest Alaska, blamed on organochlorine pesticide residues in their eggs, argues for the complete disappearance of the birds by 1980, unless corrective measures can be taken. Aleutian peregrines have not been similarly affected because of smaller residues in their eggs. 37-0045 GENERAL INFORMATION Calabrese, Edward J. and Sorensen, Alfred COMMENT ON "METHYLCYCLOPENTADIENYL MANGANESE TRICARBONYL AS AN ANTIKNOCK: COMPOSITION AND FATE OF MANGANESE EXHAUST PRODUCTS" J. Air Pollut. Control Assoc. 25. (12): 1254-6 (1975) Contradicting the statement by G.L. Ter Haar et al (See: CATS #27-0036) that methylcyclopentadienyl manganese tricarbonyl (MMT), if used as an antiknock, would not constitute a public health hazard, the authors suggest that Mn has catalytic properties which could enable it to convert S02 to sulfuric acid and particulate sulfates. Ter Haar et al refute this claim, but agree that further study is advisable. -335- ------- 38-0001 ASBESTOS Myers, John L. HANDLING ASBESTOS. CHRYSOTILE ASBESTOS IN PLASTICS J. Paint Technol. 47_ (611): 63-7 (December 1975) To gain perspective on the potential hazards of asbestos, the author describes the various types of asbestos, reviews its uses, its associated occupational and environmental health hazards, and the regulations imposed on its use by OSHA and EPA. Approximately one-third of the asbestos consumed annually is used by the plastics industry. Chrysotile asbestos, the only asbestiform mineral in the serpentine class, has over 3,000 uses and for many of these uses there is no readily available substitute. Its consumption is on the increase, with 791,020 tons being consumed in 1972 versus 686,044 tons in 1967. Chrysotile is less of a health hazard than amosite and crocidolite, which are identified as amphi- bole asbestiform minerals. Use of these latter types has decreased in recent years. When used with proper control, chrysotile should not cause any undue hazards. 38-0002 ASBESTOS Beaman, D.R. and File, D.M. QUANTITATIVE DETERMINATION OF ASBESTOS FIBER CONCENTRATIONS Anal. Chem. 48. (1) : 101-10 (1976) The use of transmission electron microscope equipped with selected area electron diffraction plus an energy dispersive spectrometer to determine the concentration of asbestos fibers in filterable liquids and solid matrices is described. Morphology, elemental composition, and crystal structure can be determined almost simultaneously and the method is +_ 30% precise. -336- ------- 38-0003 ASBESTOS Harrison, Elizabeth A. INDUSTRIAL HEALTH HAZARDS DUE TO ATMOSPHERIC FACTORS (A BIBLIOGRAPHY WITH ABSTRACTS NTIS/PS-75/800/3WJ (October 1975) The bibliography contains abstracts of research reports covering such topics as industrial medicine, occupational diseases, health of miners, and the toxicological factors of various pollutants. Some pollutants included are manganese, radon, silicon dioxide, explosives, asbestos, platinum, palladium, polyvinyl chloride, nickel, pesticides, chromium, plastics and vanadium. (Contains 202 abstracts) [Abstract in NTIS Weekly Government Abstracts, Medicine and Biology, p. 17 (5 January 1976)] 38-0004 ASBESTOS Larsen, Lee B. HEALTH HAZARD EVALUATION/TOXICITY DETERMINATION REPORT 73-135-138, KAISER PERMANENTE CEMENT CO., LUCERNE VALLEY, CALIFORNIA. PB-246 456/8WJ (May 1974) The National Institute for Occupational Safety and Health (NIOSH) in response to a request received from a representative of employees conducted a health hazard survey to evaluate exposures to free silica, asbestos, and iron oxide at the Kaiser Permanente Cement Co., Lucerne Valley, California. It has been determined that free silica and iron oxide dust were not toxic at the concentrations measured at the time of the survey. The potential toxicity of asbestos in very low con- centrations is not known at present. Air concentrations at the time of the survey were below present federal standards for asbestos. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p. 21 (5 January 1976)] -337- ------- 38-0005 ASBESTOS Ramos, Henry HEALTH HAZARD EVALUATION/TOXICITY DETERMINATION REPORT 73-133-136, ARMSTRONG CORK COMPANY, JACKSON, MISSISSIPPI. PB-246 455/OWJ (May 1974) In response to a request received from a representative of employees, the National Institute for Occupational Safety and Health (NIOSH) conducted a health hazard survey to evaluate exposures to mottle dust and asbestos, at Armstrong Cork Company, Jackson, Mississippi. It has been determined that employee exposures to mottle dust which contained small amounts of lead and asbestos found in the Mottle Area were not toxic in the concentrations measured at the time of this survey. This determination was based on low workroom concentrations of these substances and absence of medical symp- tomatology. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, pp. 20-1 (5 January 1976)] 38-0006 ASBESTOS Plant, Albert F. LEST WE FORGET: RESERVE MINING (Editorial) Chem. Eng. News _54_ (3) : 4 (19 January 1976) Using the case of Reserve Mining Company's on-and-off-dumping of its taconite tailings into Lake Superior, the author comments on the increasing complexity of pollution abatement and the long, drawn-out judicial and governmental involve- ments. Adding to the confusion involving this case, is new evidence that indi- cates air-borne asbestos-type fibers may cause cancer. -338- ------- 38-0007 BENZIDINE McCann, Joyce et al DETECTION OF CARCINOGENS AS MUTAGENS IN THE SALMONELLA/MICROSOME TEST: ASSAY OF 300 CHEMICALS Proc. Nat. Acad. Sci. USA 72. (12): 5135-9 (1975) The Salmonella/ia±croso'me mutagenlcity test seems to offer promise as a means of detecting potential carcinogens and mutagens quickly and inexpensively. To test its feasibility, this method was used to determine the mutagenicity of about 300 carcinogenic and non-carcinogenic chemicals. These chemicals included 3-naphthylamine, benzidine, bis(chloromethyl) ether, 3-propiolactone, di-n-butylnitrosamine, and ethyleneimine among those carci- nogens which tested as mutagenic. N-Methyl-N'-nitro-N-nitrosoguanidine and several related compounds are also listed as carcinogenic and mutagenic, while di-n-propyl- and di-n-pentylnitrosamine, dimethyl- and diethylnitrosamine are listed as weakly mutagenic. Other carcinogens shown as weakly mutagenic include ethylene dibromide, vinyl chloride, hydrazine sulfate, and N-(2-hydroxyethyl) hydrazine. Vinylidene chloride, listed as a questionable carcinogen, appeared to be weakly mutagenic, and ot-naphthylamine (non-carcinogenic in most studies) showed signs of mutagenicity. The non-carcinogens dibenzyl- and diphenyl- nitrosamine could not be tested adequately for mutagenicity, while the carcino- genic compound, 1,2-dimethylhydrazine showed no signs of mutagenicity. -339- ------- ETHYLENEIMINE See: 38-0007, Benzidine -340- ------- 38-0008 FLAME RETARDANTS Gutenmann, W.H. and Lisk, D.J. FLAME RETARDANT RELEASE FROM FABRICS DURING LAUNDERING AND THEIR TOXICITY TO FISH Bull. Environ. Contain. Toxicol. 14 (1):61-A (July 1975) The organophosphorus compounds tris(2,3-dlbromopropyl)phosphate (I), Pyrovatex CP (N-methylol dimethyl phosphonopropionamide) (II), and THPOH [tetrakis (hydroxy- methyl) phosphonium hydroxide] (III), commercially available flame retardants for textiles, were tested for their toxicity to goldfish at a concentration equivalent to 1 ppm, respectively, in water. During the first five days of exposure to compound I, the only halogenated phosphorus compound tested, all the fish died. Compound II did not appear to be toxic to the fish over a period of 30 days, while compound III caused some deaths. It was assumed that, because of its greater lipoid solubility, compound I was more efficiently absorbed by the goldfish. -341- ------- 38-0009 FLUOROCARBONS Anon OZONE DROP SUPPORTS DEPLETION THEORY Sci. News 109 (3): 38 (17 January 1976) Measurements of ozone concentrations in the stratosphere made by a Nimbus 4 weather satellite confirm scientific predictions that an August 1972 solar flare, which produced a huge amount of energetic protons, did in fact cause an ozone decrease. Fluxes of secondary electrons produced by the protons of dissociated nitrogen gas, causing the formation of NO, which attacked and depleted the stratospheric ozone by 16% over the North Pole. The effect was discontinuous, the drop in ozone remaining level until the NO was removed from the area by air currents. Advocates of the ozone depletion theory claim this natural event gives credence to the theory and that the discontinuous effect indicates the lack of an atmospheric sink for the chemicals involved in this ozone depletion effect 38-0010 FLUOROCARBONS Anon MCA STUDY ADDS TO FLUOROCARBON FIGHT Chem. Eng. News 54_ (3): 7-8 (19 January 1976) According to Drs. Nien Dak Sze and Mao Fou Wu of Environmental Research and Technology Inc., Concord, Mass., who conducted an MCA-sponsored study, it seems likely that there is a "tropospheric sink" that might remove chloro- fluorocarbons in the troposphere. Such a sink would cut down the halocarbons diffusing to the stratosphere and, under steady-state conditions, a sink with a 10-year lifetime would produce a drop of only 1.2% in ozone levels versus 8.5% for an infinite lifetime. Dr. Rowland, who first proposed the ozone depletion theory, reports his latest studies do not indicate that a tropo- spheric sink exists. -342- ------- 38-0011 FLUOROCARBONS Stedman, D.H. MEASUREMENT TECHNIQUES FOR THE OZONE LAYER Res./Dev. 27. (1): 22-6 (1976) Chemlluminescent techniques, electron capture gas chromatography, and a technique involving resonance fluorescence are discussed as means of determing important stratospheric reactants, leading to an understanding of how propellents react in the atmosphere. -343- ------- HALOETHERS See: 38-0007, Benzidine -34A- ------- 38-0012 HYDRAZINE Weeks, Robert W., Jr., et al FLUORESCENT DETECTION OF HYDRAZINES VIA FLUORESCAMINE AND ISOMERIC PHTHALALDEHYDES Anal. Chem. 4i8 (1): 159-61 (1975) Detection of hydrazines at the ng/cm level with fluorescamine and with a- and p-phthalaldehyde is discussed. HYDRAZINE See: 38-0007, Benzidine -345- ------- 38-0013 LIQUEFACTION AND GASIFICATION OF COAL Anon .LIQUEFACTION A SUCCESS EXXON CLAIMS Hydrocarbon Process. 54. (12): 19 (December 1975) The Exxon Donor Solvent (EDS) Process in which coal is liquefied in a non- catalytic reactor at moderate temperature and pressure is reportedly working well in the Baytown, Texas, pilot plant. Liquid products produced can be used for motor gasoline blending stocks and low-sulfur fuel oil. 38-0014 LIQUEFACTION AND GASIFICATION OF COAL Chironis, Nicholas P. NEW ATHENS, ILLINOIS. . . WINNING SITE FOR COALCON'S WINNING TECHNIQUE OF CONVERTING COAL TO LIQUIDS AND GASES Coal Age 80_ (13) : 74-7 (December 1975) ERDA chose New Athens, near Belleville, in Illinois as the location of a $237 million, 2600-tpd coal conversion demonstration plant. The plant will use Coalcon's process to produce 3900 bbl/day of liquid fuels for boilers and 22 million cfd of high-Btu pipeline gas, when ready in 1980. Factors contributing to the site selection are discussed. The site is generally free of environmental problems even though taller stacks may be required to meet air quality standards under various meteorological conditions. -346- ------- 38-0015 LIQUEFACTION AND GASIFICATION OF COAL Tillman, David A. STATUS OF COAL GASIFICATION Environ. Sci. Technol. 10_ (1): 34-8 (January 1976) The Wellman-Galusha, the Koppers-Totzek, and the Lurgi gasifiers are compared on the basic of their economic and environmental criteria. 38-0016 LIQUEFACTION AND GASIFICATION OF COAL Hughes, Evan E. et al CONTROL OF ENVIRONMENTAL IMPACTS FROM ADVANCED ENERGY SOURCES EPA/600/2-74-002. EPA Contract No. 68-01-0483 PB-239 450/OGA (March 1974) The technology and environmental effects associated with production of energy from new or advanced sources are reviewed. These include solar, geothermal, oil shale, solid wastes, underground coal gasification, and hydrogen energy sources. Projections to the year 2000 of levels of energy production from the first four of these sources are presented. Environmental impacts on air and water quality, and land use are derived per unit of energy. Levels of pollutant emissions and other environmental effects of the development of these advanced energy sources are projected. Impacts likely to require control measures are identified. Subjects for research and development directed toward control of environmental impacts are recommended. These recommendations are incorporated into a research and development plan. Approximate priority assignments derived from consideration of the timing of development and the importance and degree of definition of the identified environmental effects are given. [Abstract in: Government Reports Announcements 7_5(10): 112 (16 May 1975)] -347- ------- 38-0017 LIQUEFACTION AND GASIFICATION OF COAL Anon GOVERNMENT REPORT CITES CANCER THREAT AND OTHER PROBLEMS IN COAL CONVERSION Coal Age 80^ (12): 13 (November 1975) The Appalachian coal region is suggested as a prime area for coal conversion activities but commercial coal conversion may be a potential cause of cancer from atmospheric pollution, according to an unpublished report prepared for the President's Energy Resources Council. Nevertheless, the report recommends that the government develop commercial incentives to produce 350,000 bbl/day of synthetic oil. -348- ------- 38-0018 MODEL ECOSYSTEMS Levin, Simon A. ECOSYSTEM ANALYSIS AND PREDICTION PB-246 391/7WJ (July 1974) The Conference on EcoSystem: Analysis and Prediction held at Alta, Utah, July 1-5, 1974, was called to assess the degree to which mathematics has contributed, is contributing, and may contribute to solving the problem of the prediction of the response of ecosystems to perturbations. The conference report contains the papers presented at the conference, several additional post-conference contributions, and a summary of the discussion of each paper. The major topics discussed in the conference and subsequent report are: the threshold problem in ecosystems, difficulties in modelling populations, population-community and population-ecosystem interfaces, ecosystem level concepts, new mathematical constructs and directions, and the use of control theory in ecosystem management. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p. 6 (5 January 1976)] 38-0019 MODEL ECOSYSTEMS Sanborn, James R. THE FATE OF SELECT PESTICIDES IN THE AQUATIC ENVIRONMENT PB-239 749/5GA. EPA/660/3-74-025 (December 1974) In this study, 17 organic pesticides and five industrial chemicals were examined in a terrestrial-aquatic model ecosystem in an effort to determine their persist- ence and accumulation by the organisms of this system. Several classes of pest- icides are represented as one or more insecticides, herbicides, miticides or plasticizers were investigated in this system. The use of this system for examining uptake and persistence of widely used agricultural chemicals provides the necessary data for comparison of field data to provide a framework which can be used to assess the potential environmental impact of new pesticides before they are given a recommendation for generalized use. The data obtained from this work suggest that this model ecosystem is useful for the determination of the uptake and persistence of pesticides by the organisms. In general, it was found that most chemicals, with the exception of the persistent soil insecti- cide, dieldrin, underwent extensive degradation under the experimental conditions of the system. [Abstract in: Government Reports Announcements 75 (10): 40 (16 May 1975)J -349- ------- 38-0020 MODEL ECOSYSTEMS Bender, Edward S. and Pearson, J. Gareth RESULTS FROM AQUATIC ECOLOGICAL SURVEYS AT NEWPORT ARMY AMMUNITION PLANT, NEWPORT, INDIANA AD-A016 897/1WJ. EB-TR-7504A (October 1975) Aquatic ecological surveys were conducted at Newport Army Ammunition Plant (NAAP) from February through June 1973 to determine the effects of TNT manu- facturing and other plant operations on the water quality and stream biota of the drainages surrounding NAAP. Macroinvertebrates and stream water quality were sampled monthly, and fishes quarterly. Fishes collected were typical for streams in the area. Diversity and abundance of macroinvertebrates were affected more by natural fluctuations in the flow and runoff than by discharges or accidental spill from the TNT facility. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p.5 (5 January 1976)] -350- ------- NAPHTHYLAMINES See: 38-OQ07, Benzidine -351- ------- 38-0021 NITRILOTRIACETIC ACID Jaques, L.B. and Sue, T.K. MOBILIZATION OF CHONDROITIN SULPHATE BY NITRILOTRIACETIC ACID Toxicol. Appl. Pharmacoi. 34^ (3): 521-4 (December 1975) Examination of urine from dogs after administration of 10, 20, and 50 rag NTA/kg, using more specific tests for sulfated mucopolysaccharides, showed the excretion product to be degraded by chondroitinase AC, and to be chondroitin sulfate. -352- ------- PERCHLOROETHYLENE See: 38-0037, Vinyl Chloride -353- ------- B-PROPIOLACTONE See: 38-0007, Benzidine -354- ------- 38-0022 PHTHALATES Giam, C.S. et al CONFIRMATION OF PHTHALATE ESTERS FROM ENVIRONMENTAL SAMPLES BY DERIVATIZATION Anal. Chem. 4£ (1): 78-80 (1976) Chemical confirmation of trace amounts of phthalate ester plasticizers was made via a simple, sensitive method, which involved hydrolysis of the esters and fusion of the resultant acid with 2-chloroethylamine hydrochloride, yielding N-(2-chloroethyl)phthalimide. The phthalamide is then extracted, and analyzed by gas chromatography and an electron capture detector. A low back- ground of 30 ng or less of di-(2-ethylhexyl)phthalate results, and the phthal- itnide is separated from most of the other compounds in the environmental samples. -355- ------- 38-0023 POLYUKETHANES Anon POLYURETHANE Chem. Eng. News 5_4_ (3): 16 (19 January 1976) When completed in mid-1977, the 25% expansion underway at Firestone Tire & Rubber's foam rubber plant at Milan, Texas, will raise total capacity to over 150 million board feet/year. 38-0024 POLYURETHANES (Markets) Anon THE SLOW ROAD BACK Mod. Plast. 53_ (1): 38-51 (1976) Reviews market status of plastics in 1975, including sales, pattern of consumption, major markets, etc. Polyurethanes and polyvinyl chloride experienced consumption drops of about 20% in 1975 compared to 1974. -356- ------- 38-0025 TRICHLOROETHYLENE Vandervort, Robert and Thoburn, Theodore HEALTH HAZARD EVALUATION/TOXICITY DETERMINATION REPORT 73-68-187, McCall Printing Company, Dayton, Ohio PB-246 448/5WJ. NIOSH-TR-HHE-73-68-187 (April 1975) NIOSH conducted a health hazard survey to evaluate employee exposures to air contaminants in the letterpress room of a large printing company. It was determined from environmental and medical data that trichloroethylene was not toxic in the amounts used in paper splicing. Paper dust exposures were found to cause mild irritation in employees with allergic disorders, and exposures to'press oven smoke' resulted in episodes of minor, transient, irritative symptoms. TRICHLOROETHYLENE See: 38-0037, Vinyl Chloride -357- ------- 38-0026 SHALE OIL EXTRACTION AND REFINING Anon NEW OIL SHALE DEAL MAY TRIGGER BIG UTAH PROJECT Chem. Week 118 (2): 13 (14 January 1976) The Oil Shale Corp. (Tosco) will start predevelopment work in 1976 on a commercial-size oil shale processing plant now that the Utah Land Board has given the company permission to unitize 29 separate state oil shale leases. An eventual 75,000-bbls/day would up permanent jobs in Utah by about 1,500. SHALE OIL EXTRACTION AND REFINING See: 38-0016, Liquefaction and Gasification of Coal -358- ------- 38-0027 VINYL CHLORIDE Hoffmann, Dietrich et al CHROMATOGRAPHIC DETERMINATION OF VINYL CHLORIDE IN TOBACCO SMOKE Anal. Chem. 48_ (1): 47-50 (1976) The described chemical-analytical technique in which the vinyl chloride (VC) in tobacco smoke is converted to 1,2-dibromo-l-chloroethane (DB-VC), after being trapped on charcoal and extracted, shows the presence of up to 16 ng of VC in cigarette smoke and 20 ng in little cigar smoke, a concentration equivalent to approximately 30 ppb. The presence of VC in marijuana smoke adds to the possibility that VC can be emitted into the atmosphere by the burning of plant materials or other organic matter that contains chlorine. Quantitative determination was made via gas liquid chromatography with an electron capture detector. 38-0028 VINYL CHLORIDE Feron, V.J. et al OBSERVATIONS ON THE ORAL ADMINISTRATION AND TOXICITY OF VINYL CHLORIDE IN RATS Food Cosmet. Toxicol. 13_ (6): 633-8 (December 1975) In an effort to determine the potential toxicity of vinyl chloride monomer (VCM) when administered orally, rats were given 300 mg VCM in soya-bean oil/kg body weight by stomach intubation and 30, 100, and 300 mg VCM/kg body weight by gavage. Rats were also fed diets containing PVC powder with a VCM initial content of 1850 ppm. Over 92% of the VCM given in oil by gavage at the 300 mg level was recovered from the atmosphere within 4 hours. Rats treated in this manner showed no gain in body weight and only a slight decrease in white blood cells and blood sugar content. A significant increase was noted in liver-to-body weight, but histological liver changes did not confirm liver damage. A 2-year chronic toxicity/carcinogenicity study of the effects of orally-administered VCM in rats is underway now. -359- ------- 38-0029 VINYL CHLORIDE Hefner, R.E., Jr. et al PERCUTANEOUS ABSORPTION OF VINYL CHLORIDE Toxicol. Appl. Pharmacol. 34_ (3): 529-32 (December 1975) Monkeys were exposed to inhalation concentrations of 7000 and 800 ppm of vinyl chloride (VC) for 2.0 and 2.5 hr, respectively. The amount of VC absorbed at 7000 ppm was 0.023% and at 800 ppm it was 0.031%. Most of the VC absorbed was eliminated through the lungs. These data indicate that a 6-ft, 90-kg man exposed to 7000 ppm of VC for 2 hr would absorb 4.75 mg, an amount corresponding to exposure to 0.2 ppm in the air for 8 hr (assuming amount of inhaled air to be 10 cu m and all inhaled VC is absorbed). It is concluded that the body will absorb significant amounts of VC following short-term exposures of the skin to high concentrations but that no significant percutaneous absorption is likely to result from exposure to concentrations of VC as low as 1 or 5 ppm in the working environment. 38-0030 VINYL CHLORIDE Anon NOW PVC MOVES UP TO THE ROOFTOP IN MULTIFUNCTION SOLAR ENERGY SYSTEM Mod. Plast. .53 (1): 26, 28, (1976) Markosite Breathing Shingles from Markos Inc., Ft. Lauderdale, Florida, are roof shingles injection molded in PVC, which can be used for roofing of homes with a solar-heated hot water supply. The shingles have an acceptable UL and ASTM fire-retardance rating. -360- ------- 38-0031 VINYL CHLORIDE Tordella, J.P. PERMANENT PLASTICIZER RESINS FOR PVC Mod. Plast. 53. (1): 64-6 0-976) DuPont is developing two permanent plasticizers for PVC. Identified as PB 3041 and PB 3042, these plasticizers are high-molecular-weight ethylene copolymers, slightly crystalline, having low melting points and heats of fusion. Available as pellets or granules, the plasticizers contribute low-temperature impact resistance and high tear strength. Physical and electrical properties are tabulated. 38-0032 VINYL CHLORIDE (Production) Anon NEW DISPERSION PVC PLANT Mod. Plast. ,5_3 (1): 85 (1976) Firestone Plastics Co. is now onstream with its Perryville, Missouri, PVC plant which has a capacity of 23,000 tons. Firestone thus becomes the largest U.S. producer of dispersion-grade PVC. The new plant uses cotinuous polymer- ization and a new spray-drying technique. -361- ------- 38-0033 VINYL CHLORIDE MacBride, Roland R. THE BETTER-TIMES GAP IN VCM CAPACITY COULD LEAD TO NEW CAPTIVE VENTURES Mod. Plast. 53^ (1): 12 (1976) The summer of 1976 could see another shortage of VCM because no significant increase in capacity has occurred since early 1975 and expectations are that by mid-1976 there will be 588,000 tons more PVC capacity. The increased PVC capacity results from a gain of 716,000 tons via Georgia-Pacific, Robintech, Firestone and Tenneco minus 128,000 tons from the drop out of Olin and Uni- royal. Although indications are that some 800,000 additional tons of VCM may be needed by 1979, Conoco Chemicals is the only producer contemplating a large expansion, but Borden is building, Robintech is trying to buy a VCM facility, etc. As of 1 January 1976, the price of VCM rose by 1.6/lb to 12.6£/lb. 38-0034 VINYL CHLORIDE (Production) Anon VINYL DISPERSION RESINS Chem. Eng. News .54_ (3) : 16 (19 January 1976) Union Carbide will close its plant at South Charleston, W. Virginia, by the end of 1976, thus elimininating 40 million Ib/yr of PVC homopolymers and vinyl chloride-vinyl acetate copolymer resins. Carbide will continue to manufacture solution and suspension vinyl resins. -362- ------- 38-0035 VINYL CHLORIDE (Markets) Baba, Theodore B. and Kennedy, James R. ETHYLENE AND ITS COPRODUCTS: THE NEW ECONOMICS Chem. Eng. 83_ (1) : 116-28 (5 January 1976) Impact on the economics of ethylene and other petrochemicals stemming from possible need to use heavier feedstocks is reviewed. Polyvinyl chloride and other plastics consume most of the ethylene produced. 38-0036 VINYL CHLORIDE Dwyer, F.G. et al EFFICIENT, NONPOLLUTING ETHYLBENZENE PROCESS Chem. Eng. 83_ (1): 90-1 (5 January 1976) A new alkylation catalyst developed jointly by Mobil Oil Corp. subsidiaries and The Badger Co., offers economic and environmental advantages for the production of ethylene. The catalyst, successfully tested in a 40-million- Ib/yr demonstration plant, is environmentally inert. Process streams do not require treatment. -363- ------- 38-0037 VINYL CHLORIDE Gay, Bruce W., Jr., et al ATMOSPHERIC OXIDATION OF CHLORINATED ETHYLENES Environ. Sci. Technol. 10 (1): 58-67 (1976) To provide additional information leading to an understanding of the atmospheric degradation of halogenated compounds, photooxidation reactions and products of ethylene (and various chlorinated ethylenes) and nitrogen dioxide were measured. Reactivities of the compounds were rated as follows: 1,1-dichloroethylene (vinylidene chloride) > 1,2-dichloroethylene-trichloroethylene > ethylene > vinyl chloride > tetrachloroethylene (perchloroethylene). Photooxidation products are discussed. VINYL CHLORIDE See: 38-0003, Asbestos See: 38-0007, Benzidine See: 38-0024, Polyurethanes -364- ------- VINYL'IDENE CHLORIDE See: 38-0007, Benzidine See: 38-0037, Vinyl Chloride -365- ------- 38-0038 ETHYLENE DIBROMIDE Dumas, T. and Bond, E.J. BROMIDE RESIDUES IN APPLES FUMIGATED WITH ETHYLENE DIBROMIDE J. Agric. Food Chem. 23 (1): 95-8 (1975) Three varieties of apples were fumigated with 8-24 mg/1 of ethylene dibromide (EDB) for 4 hr at 13°C and held at this temperature. In less than 13 days, the EDB residues in the pulp and skin had dropped to less than 0.1 ppm. At 20°C, it took only 5 days for the residues to decline to negligible levels; at 25°C, only 4 days. At a storage temperature of only 4°C, however, higher residues persisted for almost 4 weeks before dropping to the 0.1 ppm level. Levels of up to 30 ppm of EDB in the seeds immediately after fumigation did. not decline during 13 days of storage at 13°C. Inorganic bromide residues after the desorption of organic bromide were from 2.0-4.8 ppm, even when the amount of EDB used in fumigation was twice the effective dosage used in practice. (A summary of this article in Food, Cosmet. Toxicol. IJ (6): 671 (Dec. 1975) describes these results as "fairly reassuring" since an earlier report had indicated that repeated doses of EDB had caused squamous-cell carcinomas in the forestomach of rats and mice.) ETHYLENE DIBROMIDE See: 38-0007, Benzidine -366- ------- 38-0039 NITROSAMINES Shapley, Deborah NITROSAMINES: SCIENTISTS ON THE TRAIL OF PRIME SUSPECT IN URBAN CANCER Science 191 (4224): 268-70 (23 January 1976) Nitrosamines, known animal carcinogens, have recently been detected in air, soil, water, and sewage treatment plants from NYC to West Virginia. Although nitrosamines have not yet been identified as human carcinogens, there is a potential that may be health hazards. It may be that nitrosamines, rather than NO or M^, are responsible for the high levels of cancer correlated with the nitrogen oxides in some urban areas. Control of nitrosamines may be difficult since they are generated from various chemicals almost anywhere in the environment. From the levels of dimethylnitrosamine (DMN) measured in Belle, W. Va., humans could inhale 1 to 1.4 yg of DMN on a clear day. 38-0040 NITROSAMINES Weekes, U.Y. METABOLISM OF DIMETHYLNITROSAMINE TO MUTAGENIC INTERMEDIATES BY KIDNEY MICROSOMAL ENZYMES AND CORRELATION WITH REPORTED HOST SUSCEPTIBILITY TO KIDNEY TUMORS J. Nat. Cancer Inst. 55. (5): 1199-1201 (November 1975) Purified kidney microsomal enzymes from certain mice were highly capable of generating mutagenic intermediates from dimethylnitrosamine. In the mouse strains examined, the study showed a correlation between the susceptibility of certain organs to tumors induced by this compound and the ability of the same organs to activate the nitrosamine to mutagenic metabolites in vitro. -367- ------- 38-0041 NITROSAMINES Althoff, Jiirgen et al CARCINOGENIC EFFECT OF 2,2'-DIMETHYLDIPROPYLNITROSAMINE IN SYRIAN HAMSTERS J. Nat. Cancer Inst. 55 (1): 1209-11 (November 1975) Syrian hamsters injected sc once a week for life at levels of 500, 250, 125 and 62.5 mg/kg body weight with 2,2'-dimethyldipropylnitrosamine (DMDPN) developed neoplasms in the nasal cavities, larynx, trachea, and bronchi, but not in other organs. Comparisons are made with the carcinogenic effects of di-n-propylnitrosamine (DPN), previously attributed to oxidation at the beta carbon. DMDPN, however, could not undergo beta oxidation. It is suggested that beta oxidation might be involved in liver, pancreas and kidney cancer development and that different metabolic pathways govern the develop- ment of cancers in different organ systems. 38-0042 NITROSAMINES Phillips, J.C. et al STUDIES ON THE METABOLISM OF DIMETHYLNITROSAMINE IN THE RAT. II. THE EFFECTS OF PHENOBARBITONE AND 20-METHYLCHOLANTHRENE ON THE IN VITPO AND IN VIVO METABOLISM AND ACUTE TOXICITY OF DIMETHYLNITROSAMINE IN YOUNG AND MATURE RATS Food Cosmet. Toxicol. 13_ (6): 611-17 (December 1975) Examination of livers from 5-week old and 16-week old male and female rats given C-labelled dimethylnitrosamine (DMN) ip showed similar levels of DMN demethylase activity and comparable liver weights, microsomal protein and cytochrome P-450 content. There was no significant difference in the acute toxicity (LD5g) of DMN in either the young or old animals, but the LD5Q was reduced in mature females pretreated with phenobarbitone. -368- ------- 38-0043 NITROSAMINES Fiddler, W. et al DIMETHYLNITROSAMINE IN SOUSE AND SIMILAR JELLIED CURED-MEAT PRODUCTS Food Cosmet. Toxicol. 13_ (6): 653-4 (December 1975) Analysis of 7 samples of commercial souse, two samples of blood and tongue, and one of head cheese showed that 8 of the 10 samples contained from 3 to 63 yg/kg of dimethylnitrosamine (DMNA). These jellied products, cured with nitrite or nitrite-nitrate, are not widely used in the U.S. but may be important parts of diets elsewhere. Products containing gelatin will be analyzed for DMNA, since nitrosamines are potential carcinogens and relatively little is known about their presence in the human diet. -369- ------- 38-0044 GENERAL INFORMATION Anon RED DYE 2 FADE-OUT? Chem. Week 118 (3): 17 (21 January 1976) The removal of Red Dye No. 2 from the FDA's 1960 list of provisionally approved food colorings is being considered. This action follows the release of an FDA report which showed that one-third of the female rats fed large doses of that dye for two and a half years developed cancer of the kidney, liver or muscles, or lukemia. The highest dosages of 300 ppm given to animals appeared five times more likely to develop cancer than those fed lower dosages. Rats younger than two did not develop malignancies, a fact which may explain why cancer was not detected in the FDA research conducted for 24 months in the 1950's The FDA also intends to ban the use of the growth stimulant, diethylstilbestrol (DES) and to issue a warning of an association between uterine cancer and some estrogen drugs. 38-0045 GENERAL INFORMATION Duffle, John A. and Beckman, William A. SOLAR HEATING AND COOLING Science 191 (4223): 143-9 (16 January 1976) One-quarter of the nation's energy use consists of thermal energy for buildings at temperatures near or below 100°C. Solar heating and cooling for buildings delivered from flat-plate solar energy collectors is expected to be the first large-scale application of solar energy. The authors consider and discuss tech- nical, economic and social factors influencing this development, including archi- tectural constraints, special tax and government inducements, and utilization of existing information and data. -370- ------- 38-0046 GENERAL INFORMATION Fisher, Nicholas S. NORTH SEA PHYTOPLANKTON Nature 259 (5539): 160 (15 January 1976) The author suggests that the presence of persistent industrial pollutants partially accounts for the large scale changes in North Sea phytoplankton communities detected since the mid-1960s by the Continuous Plankton Recorder survey and described by P.C. Reid (Nature 257. 217-9 (1975). The observed decline in diatom populations, possible increase in microflagellate abun- dance, and a decline in the zooplankton biomass could not be easily explained by eutrophication and climatic changes alone, according to Reid. Sensitivity to low levels of industrial waste products, such as heavy metals, petroleum hydrocarbons, and stable chlorinated hydrocarbons by marine phytoplankton has been demonstrated by general researchers. The author recognizes that many other environmental factors affect these biological systems as well. 38-0047 GENERAL INFORMATION Anon WARNING ON KEPONE Chem. Week 118 (2): 18(14 January 1975) Of the 36 formulators, shippers, packagers and handlers of Kepone recently contacted by OSHA about 19 were still using the chlorinated pesticide. OSHA instructed the users to limit their employees' exposure to Kepone and requested that concentrations of the chemical be monitored and measured in the work- place. The companies can expect to be inspected to determine the adequacy of control methods, of personal protective equipment, of training in proper handling and of records relating to Kepone. -371- ------- 38-0048 GENERAL INFORMATION Anon HEALTH EFFECTS OF THE PESTICIDE KEPONE. . . Chem. Eng. News 54. (3): 34 (19 January 1976) Researchers at the Medical College of Virginia have a one-year contract with the National Institute of Environmental Health Sciences to study the health effects of Kepone and to develop therapy for those affected by the pesticide. More than half of the 110 or more workers at plant in Hopewell, Va., which produced Kepone, have high levels of the pesticide in their blood. Twenty workers have been hospitalized with various neurological disorders. 38-0049 GENERAL INFORMATION Carpenter, C.P. et al PETROLEUM HYDROCARBON TOXICITY STUDIES. VI. ANIMAL AND HUMAN RESPONSES TO VAPORS OF "60 SOLVENT"; VII. ANIMAL AND HUMAN RESPONSES TO VAPORS OF "70 SOLVENT"; and VIII. ANIMAL AND HUMAN RESPONSE TO VAPORS OF "140° FLASH ALIPHATIC SOLVENT" Toxicol. Appl. Pharmacol. J34_ (3), 374-94; 395-412; 413-29 (December 1975) These three studies paralled the work performed by the same authors on varnish makers' and painters' naphtha, Stoddard solvent, rubber solvent, and mixed xylenes. A stepwise Approach was used to determine a no-ill-effect inhalation level in rats and dogs. Based on results of inhalation studies with animals and sensory response of human subjects described in these investigations, hygienic standards are sug- gested: 0.44 mg/liter (90 ppm) concentration of "60 Solvent", 0.32 mg/liter (59 ppm) concentration of "70 Solvent", and 0.23 mg/liter (37 ppm) concentration of "140° Flash Aliphatic Solvent." -372- ------- 38-0050 GENERAL INFORMATION Anon REPORT TO THE CONGRESS ON OCEAN DUMPING RESEARCH, JANUARY THROUGH DECEMBER 1974, PUBLIC LAW 92-532, TITLE II SECTION 201. NOAA-75091603, COM-75-11410, National Oceanic and Atmospheric Administration, Washington, D.C. (June 1975) This is the second annual report submitted to Congress on the federally sponsored research on the effects of ocean dumping, as required under Section 201. The report describes significant Federal research programs and activities carried out in 1974. It also includes a summary of 1974 studies relative to the requirements of Section 203. It contains sections on research on ocean disposal of dredge and nondredged material, dumpsite characterizations, Coast Guard R & D for ocean dumping surveillance and enforcement, dredged material disposal in the Great Lakes, and research on alternatives to ocean dumping. During 1974 approximately 130 million tons of material were dumped in U.S. coastal waters. Dredged material accounted for 118 million tons, or over 90% of the total tonnage dumped in 1974. Dredged material is an environmental concern because of the large quantities involved and the presence of con- taminated sediments. The ocean disposal of wastes other than dredged materials occurs mainly in the New York Bight. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p.6 (5 January 1976) 38-0051 GENERAL INFORMATION Lee, Richard F. FATE OF PETROLEUM HYDROCARBONS IN MARINE ZOOPLANKTON NSF/IDOE-75-31, PB-245-699. Published in Conference on Prevention and Control of Oil Pollution Effects pp. 549-53, Skidaway Institute of Oceanography, Savannah, Georgia (1975) The work described in the paper is concerned with the uptake, metabolism, storage, and discharge of petroleum hydrocarbons by marine zooplankton, an important link in the marine food web. Both paraffinic and polycyclic aromatic hydrocarbons were added to seawater containing various species of zooplankton collected off California, British Columbia, and in the Arctic. Uptake was linear for 24 hours with no further increase in stored hydrocarbon after that time. Most ingested hydrocarbon was metabolized and discharged by the various crustacean species although a small percentage (less than 1% of the ingested hydrocarbon) was stored by all species even after a long depuration time. Preliminary work has suggested that hydrocarbons are metabolized and discharged at a greater rate when absorbed to ingested algae. No metabolism of hydro- carbons by the algae cells was noted. Also, alkylated aromatic hydrocarbons appear to be metabolized at a higher rate than the nonalkylated aromatic hydro- carbons. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology p.6 (5 January 1976)] -373- ------- 38-0052 GENERAL INFORMATION McNutt, Neil S. and Amster, Robert L. HEPATIC LESIONS IN MICE AFTER CONTINUOUS INHALATION EXPOSURE TO 1,1,1-'TRICHLORO- ETHANE AD-A017-247, Published in Laboratory Investigation^ (5): 642-54 (1975) Male CF-1 mice (24-34 gm.) were exposed to either 250 ppm or 1000 ppm of 1,1,1-trichloroethane in air continuously for 14 weeks; control mice were exposed to room air. Serial sacrifice of exposed and control mice demonstrated significant changes in the centrilobular hepatocytes of animals in the 1000 ppm group. Moderate liver triglyceride accumulation was evident in the 1000 ppm group and peaked at 40 mg. per gm. of tissue (wet weight) after 7 weeks of exposure. Partical recovery was indicated by a decrease in the hepatic trigly- ceride level to 16 mg. per gm. by 14 weeks of exposure to 1000 ppm. Electron microscopic evaluation revealed that cytoplasmic alterations were most severe in centrilobular hepatocytes in the 1000 ppm group and were mild to minimal in the 250 ppm group. These alterations consisted of vesiculation of the rough endoplasmic reticulum, with loss of attached polyribosomes, increased smooth endoplasmic reticulum, microbodies, and triglyceride droplets. Necrosis of individual hepatocytes occurred in 40% of the mice exposed to 1000 ppm for 12 weeks. Comparison of these findings to results obtained by other investigators studying dichloromethane indicates that these pathologic alterations were similar to those observed with dichloromethane, except for different time courses of the effects and different degrees of recovery. The toxic effects of 1,1,1-trichloroethane were similar to but less severe than those produced by carbon tetrachloride. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology p. 12 (5 January 1976)] -374- ------- 39-0001 ARSENIC Gills, I.E. et al DETERMINATION OF TOXIC TRACE ELEMENTS IN BODY FLTTID REFERENCE SAMPLES PB-246 786. Pub. in Proc. Ann. Conf. on Trace Substances in Environ. Health (8th), Missouri-Columbia Univ., 11-13 June 1974, 8_, 273-80 (1974) The measurement of elemental concentration in body fluids has been widely used to give indication of exposures to certain toxic materials and/or a measure of body burden. To understand fully the toxicological affect of these trace elements on the physiological system, meaningful analytical data is required along with accurate standards. A number of reference samples containing selected toxic trace elements in body fluids have been prepared. The reference samples include mercury in urine at three concentration levels, and lead in blood at two concentration levels. These reference samples have been found to be extremely useful for the evaluation of field and laboratory analytical methods for the analysis of toxic elements. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p.77 (26 January 1976)] 39-0002 ARSENIC Zook, Elizabeth G. et al NATIONAL MARINE FISHERIES SERVICE PRELIMINARY SURVEY OF SELECTED SEAFOODS FOR MERCURY, LEAD, CADMIUM, CHROMIUM, AND ARSENIC CONTENT J. Agric. Food Chem. 24^ (1): 47-53 (January - February 1976) The results of a screening study to determine the mineral concentrations in fish consumed in the U.S. delineates the microconstituent content of arsenic, mercury, lead, cadmium, and cobalt in 34 kinds of seafood. A higher concentra- tion of arsenic than of any other of the tested elements was reported, the overall arsenic mean being 2.6 ppm compared to less than 0.2 ppm for cadmium, less than 0.4 ppm for chromium, less than 1 ppm for lead, and 0.13 ppm for mercury. However, fish as a rule are known to show relatively high levels of arsenic, and the arsenic in shrimp, for example, exists in a form not readily assimilated by humans or animals. -375- ------- 39-0003 ASBESTOS Gunter, Bobby J. HEALTH HAZARD EVALUATION/TOXICITY DETERMINATION REPORT 73-149-140, FEDERAL- MOGUL CORPORATION, GALLIPOLIS, OHIO PB-246 460. NIOSH-TR-HHE-73-149-140 (June 1974) The National Institute for Occupational Safety and Health (NIOSH) in response to a request received from a representative of employees conducted a health hazard survey to evaluate worker exposure to iron, copper, total dust, asbestos, and carbon monoxice at the Federal-Mogul Corporation, Gallipolis, Ohio, during the manufacture of automobile transmission parts. Based upon results obtained from environmental observations, medical questionnaires, and the Industrial Hygienist's personal observations, it was determined that a health hazard did exist at the time of the evaluation. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p.56 (19 January 1976)] 39-0004 ASBESTOS Menis, 0. et al THE APPLICATION OF THERMOANALYTICAL METHODS TO THE ENVIRONMENTAL HEALTH PROBLEMS PB-247 009. Pub. in Proc. of ICTA Conference (4th), Budapest, Hungary, 8-13 July 1974, Chapter in Thermal Analysis _3» 127-39, 1975. Differential thermoanaly.sis methods provided an independent measurement of quartz and chrysotile asbestos in the preparation of calibration standards needed by environmental control agencies. It was found that 30-500 micro- grams of chrysotile asbestos could be measured with a relative standard deviation of 15 percent. Sealed silver containers were used to provide a self- generating atmosphere which reduced the spread of the dehydroxylation peak and improved both selectivity and sensitivity. A repeat-measurement of the thermal curve, after the dehydroxylation, provided a correction for the matrix baseline. Under similar experimental conditions, microgram quantities of quartz were determined with a relative standard deviation of approx. 2 percent. However, there was a 50 percent difference between the NBS-ICTA SRM 759 and commercially prepared material. It was shown that this difference could be eliminated by thermally treating the commercial product. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p.75 (26 January 1976)] -376- ------- 39-0005 ASBESTOS Anon ASBESTOS-FREE TALC Rubber Age 108 (1): 56 (1976) Available from Pennsylvania Minerals & Mining Co., Aspers, Pa., the asbestos- free talc, SER-X, is a hydrous alumina silicate that can be used in dusting molds, as a basic rubber filler, and as a means of keeping rubber layers from sticking to each other. -377- ------- 39-0006 BENZIDINE Ferber, Kelvin, H. et al AN ASSESSMENT OF THE EFFECT OF IMPROVED WORKING CONDITIONS ON BLADDER TUMOR INCIDENCE IN A BENZIDINE MANUFACTURING FACILITY Am. Ind. Hyg. Assoc. , J. 37. (1): 61-8 (1976) The hazards of benzidine as a bladder carcinogen were reported as early as 1940, and the potential carcinogenicity of benzidine sulfate was recognized about 10 years later, at which time industry began to study the problem. About 1950, Allied Chemical undertook a study of the manufacturing processes in its Buffalo dye manufacturing plant and during the next five years developed a fully enclosed wet process for benzidine sulfate aimed at reducing worker exposure to all forms of benzidine. A statistical analysis of records accumulated in the ensuing years shows that the new process significantly reduced the number of bladder tumors among employees, No bladder tumors have occurred in any worker employed since the first of 1955. -378- ------- 39-0007 BORON Versar, Inc. PRELIMINARY INVESTIGATION OF EFFECTS ON THE ENVIRONMENT OF BORON, INDIUM NICKEL, SELENIUM, TIN, VANADIUM AND THEIR COMPOUNDS. VOLUME I - BORON. PB-245 984. EPA/560/2-75/005a (August 1975) This first in a series of reports on the title materials covers: boron industry in the United States; production; uses of boron compounds; current practices; environmental contamination; monitoring and analysis; chemical reactivity; biology; environmental effects; toxicity; current regulations and effects levels; and standards. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p.31 (12 January 1976)] -379- ------- 39-0008 ETHYLENEIMINE Anon PEI POLYMERS...INFINITE MODIFICATIONS, PRACTICAL VERSATILITY The Dow Chemical Company. Brochure, Form No. 192-328-74 Physical properties, reactions, applications, storage and handling, safety considerations and disposal of polyethyleneimine (PEI) polymers are discussed. Although PEI products are not considered to be serious health hazards "under anticipated conditions of operation", they can cause eye and skin irritation on contact and should be carefully handled to minimize generation of dusts or mists. According to tests on rats and dogs, PEI products show low repeated ingestion toxicity, but overexposure caused injury to the kidney and liver. -380- ------- 39-0009 FLUOROCARBONS Anon ECONOMIC IMPACTS ASSESSED FOR FLUOROCARBONS BANS. . . Chem. Eng. 83_ (2) : 55 (19 January 1976) If all uses of the fluorocarbons, F-ll and F-12, and of carbon tetrachloride were banned in the U.S., there would be a 92% decrease in emissions over a 20-year period. This decrease would ease the ozone depletion threat, according to an Arthur D. Little, Inc. report to the EPA, but would impose a severe economic impact on numerous industries. Some 15 compounds that could cause ozone depletion are listed; 18 alternative regulatory actions are considered in light of their economic effects on F-ll, F-12, CCl^, and on F-22 and methyl chloroform. 39-0010 FLUOROCARBONS Anon BALLOON PROBES SEEK FLUOROCARBON DATA Chem. Eng. News .54 (5) : 5-6 (2 February 1976) In conjunction with the National Oceanic & Atmospheric Administration, researchers at the University of Wyoming, Laramie, will launch balloon probes to study the reactions of chlorofluorocarbons 11 and 12 at more than 50,000 feet above the earth. The study will also investigate the possible effects of nitric oxide on stratospheric ozone. -381- ------- 39-0011 HYDRAZINE Koshy, K. Thomas et al PHOTOLYSIS OF BENZOIC ACID 2-(2,4,6-TRICHLOROPHENYL)HYDRAZINE J. Agric. Food Chem. 2J3 (6): 1084-8 (November - December 1975) By use of TLC, GLC, and GLC-MS, eight photolysis products of benzoic acid 2-(2,4,6-trichlorophenyl)hydrazide were identified. Of these, the two major products were benzoic acid 2-(2,4-dichlorophenyl)hydrazide and 2,4,6-trichloro- benzophenone. The title hydrazide, which is the main hydrolysis product of the miticide, benzoyl chloride (2,4,6-trichlorophenyl)hydrazone, was investigated because it was found as a residue on citrus leaves sprayed with the hydrazone miticide. -382- ------- 39-0012 MODEL ECOSYSTEMS Wallis, Ian G. MODELLING THE IMPACT OF WASTE ON A STABLE FISH POPULATION Water Res. 9_ (12): 1025-36 (1975) Analytical and simulation studies of a model developed to determine the effects of waste discharges on a stable fish population indicate the usefulness of a simple model and show that biomass is a sensitive means of describing mortality changes in environments with comparatively small fluctuations. 39-0013 MODEL ECOSYSTEMS Hart, F.L. and Helfgott, T. BIO-REFRACTDRY INDEX FOR ORGANICS IN WATER Water Res. 9. (12): 1055-9 (1975) A refractory-index classification is described and shown to be a useful measure of persistence of materials usually found in the ecosystem. The studies in- dicate> that certain common organic compounds, which resist degradation for a long time, should be prevented from entering the waterways, if possible. -383- ------- 39-0014 MODEL ECOSYSTEMS Harrison, Elizabeth A. ECOSYSTEM MODELS (A BIBLIOGRAPHY WITH ABSTRACTS). NTIS/PS-75/846 The bibliography contains abstracts which cover marine biology, natural resources, wildlife, plants, water pollution, microorganisms, food chains, radioactive sub- stances, limnology, and diseases as related to ecosystem models. (Contains 214 abstracts) [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, pp. 49-i>U (19 January 1976)J 39-0015 MODEL ECOSYSTEMS Russell, Clifford S. ECOLOGICAL MODELING IN A RESOURCE MANAGEMENT FRAMEWORK. PB-246 665. RFF Working Paper-QE-1, ISBN-0-8018-1773-0, NOAA-75101506 (July 1975). (Available from Johns Hopkins Univ. Press, Baltimore, Md. 21218 at $6.00) The report is a collection of papers concerning both physical and ecological modeling for a number of specific locations. Titles of the papers are: Ecological modeling in a resource management framework: An introduction; CLEANER: The Lake George model; A discussion of CLEAN, The aquatic model of the Eastern deciduous forest biome; The Delaware Estuary model; Application of mathematical models to the study, monitoring and management of the North Sea; Phytoplankton models and eutrophication problems; Fish population models; Potential and actual links to ecological models; Fisheries and ecological models in fisheries resource management; Management of large-scale environmental modeling projects; and Present problems and Future prospects of ecological modeling. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p. 50 (19 January 1976) ] -384- ------- 39-0016 MODEL ECOSYSTEMS Bull, Don L. and Ivie, G. Wayne METABOLISM OF 0-ETHYL <9-[4-METHYLTHIO)PHENYL] S-PROPYL PHOSPHORODITHIOATE (BAY NTN 9306) BY WHITE HATS J. Agric. Food Chem. 24 (1): 143-6 (January - February 1976) The title compound, an experimental organophosphorus insecticide having fairly low mammalian toxicity (acute oral LDcQ for rats: 227 mg/kg), was rapidly metabolized and excreted by rats who had received an oral dose of 10 mg/kg. Approximately 92% was excreted in the urine in 24 hr. Radioactive residues peaked in all tissues 2 hr after treatment (0.84 ppm, blood; 0.25 ppm, brain; 4.27 ppm, liver; 8.38 ppm, kidney; 0.25 ppm, muscle; and 1.20 ppm, fat) but dropped to less than 0.1 ppm after 72 hr. 39-0017 MODEL ECOSYSTEMS Ivie, G. Wayne et al METABOLIC FATE OF 0-ETHYL 0-[4-(METHYLTHIO)PHENYL-14C] S-PROPYL PHOSPHORO- DITHIOATE (BAY NTN 9306) IN A LACTATING COW J. Agric. Food Chem. 2k_ (1): 147-51 (January - February 1976) The title compound, a promising experimental insecticide, was not rapidly absorbed by a cow who had been given a 0.12 mg/kg oral dose. Residues in venous blood reached a maximum in 12-24 hr after treatment but were never higher than 0.005 ppm. During the 6 days following treatment, about 90% of the dose was excreted via the urine, about 0.1% in milk, and the rest in the feces. The cow, given a second dose of 0.62 mg/kg ten days after the first dose, was sacrificed 12 hours later. Tissue analysis revealed low residues, the highest being 0.21 ppm in the kidney. Major metabolites apparently are not toxicologi- cally significant. -385- ------- 39-0018 MODEL ECOSYSTEMS Brown, Lewis R. et al THE EFFECT OF MIREX AND CARBOFURAN ON ESTUARINE MICROORGANISMS PB-247 147. EPA/660/3-75/024 (March 1975) The purpose of the investigation was to help establish the chemical, physical and micro-biological fate of mirex and carbofuran in the estuarine environ- ment and determine the effect(s) on important estuarine microorganisms and their activities. Chemical studies on the adsorption, fate and hydrolysis were conducted. The micro-biological studies involved the use of both pure cultures and mixed cultures in a microcosm system and included twelve distinct physiological groups of microorganisms. It was concluded that neither mirex nor carbofuran would have a deleterious effect on estuarine bacteria under normal conditions, and there was no evidence of bioaccumula- tion. Degradation products of both compounds were shown to be toxic to some microorganisms. -386- ------- 39-0019 PHTHALATES Kevy, Sherwin V. et al TOXICOLOGY OF PLASTIC DEVICES HAVING CONTACT WITH BLOOD PB-247 168. NIH/NHLI-72-2969-CR (October 1975) The objectives of this research were twofold: (1) the utilization of an animal model to evaluate the functional effect of Di-2-ethylhexylphthalate (DEHP) accumulation, and (2) the development of an in vitro testing procedure that could be correlated with the animal studies. The rate of extraction of DEHP from polyvinyl chloride (PVC) is dependent upon both the temperature during storage and the lipid content of the medium. DEHP so obtained is in true solution, with particle sizes less than 0.22 micron. Tissue culture studies demonstrate that solubilized DEHP in varying concentrations inhibits the growth and ultimately kills human diploid fibroblasts. PVC and siliconized glass transfused rhesus had abnormalities in liver histopathology and liver functions for up to 14 months following cessation of transfusions. DEHP or silicon persisted in the tissues for up to 14 months post-transfusion. Both the control rhesus and those transfused with platelets processed in poly- ethylene containers were normal. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p.68 (26 January 1976)] -387- ------- 39-0020 POLYURETHANES Jellinek, H.H. G. and Takada, K. TOXIC GAS EVOLUTION FROM POLYMERS: EVOLUTION OF HYDROGEN CYANIDE FROM LINEAR POLYURETHANE J. Polym. Sci., Polym. Chem. Ed. 13 (12): 2709-23 (1975) Linear polyurethane was heated (from about 260 to 480°C) in the presence and absence of oxygen and the evolution of HCN was determined as a function of time, temperature, oxygen pressure, film thickness, and chain length. The mechanisms of thermal oxidative degradation are compared with those of thermal degradation. -388- ------- 39-0021 TRICHLOROETHYLENE Bloom, T.F. et al HEALTH HAZARD EVALUATION/TOXICITY DETERMINATION REPORT 73-151-141, ESSEX WIRE CORPORATION, KENTON, OHIO PB-246 461. NIOSH-TR-HHE-73-151-141 (August 1974) NIOSH received a request to evaluate employee exposure to trichloroethylene used as a solvent in degreasing operations and to dodecyl-succinic anhydride used as an epoxy hardener in the epoxy molding area at a plant manufacturing ignition coils. It was determined on the basis of environmental measurements that trichloroethylene and dodecyl-succinic anhydride were not toxic at the concentrations found at the time of the survey. However, historical accounts suggest that past environmental exposures may have been at toxic concentrations. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p.56 (19 January 1976)J -389- ------- 39-0022 SHALE OIL EXTRACTION AND REFINING Blinova, E.A. and Janes, H. THE EXPERIMENTAL TOXICOLOGICAL CHARACTERISTICS OF THE BASIS PRODUCTS OF THE SHALE CHEMICAL INDUSTRY PB-246 833-T. EPA-TR-76-55. (August 1975) The report discusses the toxicological effects of the products of thermal processing of shale (tars and phenols). Experiments were conducted to determine the effects of these products on guinea pigs after inhalation and contact with the skin. The experimental results indicate that shale tars and phenols produced in the Estonian SSR are irritants and [after] a period of exposure affect the skin. Other physiological effects are noted. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology (19 January 1976)] 39-0023 SHALE OIL EXTRACTION AND REFINING Prescott, James H. SOVIET OIL-SHALE PROCESSES OFFERED FOR U.S. LICENSING Chem. Eng. £3 (3): 66-7 (2 February 1976) Operating details and cost data for two Soviet oil-shale processes, the Kiviter process and the Galoter process, are described briefly. The Soviets are offering the processes for U.S. licensing. Capital costs would probably run higher in the U.S. because of environmental pollution control equipment and other factors. -390- ------- .39-0024 VINYL CHLORIDE Anon VINYL MAKERS READY TO CLEAR AIR Chem. Week 118 (4): 33 (28 January 1976) Industry is apparently not going to fight EPA's proposed standards for regulat- ing air emissions from VC and PVC plants, although the cost of the control techniques to be required will run high. A price increase in finished products is anticipated. 39-0025 VINYL CHLORIDE Lao, R.C. et al IMPROVED METHODS FOR SAMPLING AND ANALYSIS OF VINYL CHLORIDE Am. Ind. Hyg. Assoc., J. 37. (1): 1-7 (1976) Gas chromatography provides a means for accurate and reliable detection of vinyl chloride in ambient and in-plant atmospheres. The authors describe results achieved with various sample types. -391- ------- 39-0026 VINYL CHLORIDE Anon VINYL CHLORIDE MONOMER — HANDLING AND PROPERTIES PPG Industries, Chemical Division, 1975 In 1975, PPG stood as a major supplier of vinyl chloride monomer, having a 900 million-lb/yr capacity in its Louisiana and Puerto Rico facilities. This brochure describes the company's work practice guidelines, following OSHA recommendations; gives the properties and hazards of VCM; discusses handling and unloading procedures; disposal; and monitoring and analysis. VINYL CHLORIDE See: 39-0019, Phthalates -392- ------- 39-0027 ETHYLENE DIBROMIDE Going, John and Long, Sue SAMPLING AND ANALYSIS OF SELECTED TOXIC SUBSTANCES TASK II - ETHYLENE DIBROMIDE PB-246 213. EPA/560/6-75-001 (September 1975) Ethylene dibromide has recently been reported by the National Cancer Institute to be a potential carcinogen. Its commercial use is predominately as a scaveng- ing agent for lead in gasoline. A minor usage is a pesticide fumigant. A protocol was developed for the sampling and analysis of ethylene dibromide in ambient air and surface water. The range in concentration of ethylene di- bromide in the air and the site where it was collected are as follows; manu- facturing sites, 4.2 to 115 micrograms per cu m oil refinery, 0.23-1.65 micro- grams per cu m; urban locations near retail gasoline stations and with heavy vehicular traffic, 0.069 to 0.11 micrograms per cu m. Two water samples collected from streams near an oil refinery and a manufacturing site were found to contain 1.13 and 1.05 parts per billion ethylene dibromide, respectively. Further work to clarify ambient air levels and to assess whether they may represent a health risk is anticipated, but the very low levels detected to date are not thought to present a significant risk to health. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology (19 January 1976)] -393- ------- 39-0028 NITROSAMINES Read, John THE LETHAL EFFECT ON BACTERIA OF DIMETHYLNITROSAMINE USED WITHOUT AN ACTIVATING AGENT Mutat. Res. J33 (2/3)': 107-12 (December 1975) Survival curves obtained when various strains of E. coli and Salmonella were treated with the oncogenic agent dimethylnitrosamine (DMN) in solutions of varying concentrations are discussed. The results indicate the lethal effect of DMN on bacteria is due to its attacking the deoxyribonucleic acid (DNA) of the bacteria. The damage can be repaired by those systems that repair damage caused by UV light or X radiation. 39-0029 NITROSAMINES Fisher, C.R. et al MUTAGENICITY OF ACTINOMYCIN D IN NEUROSPORA CRASSA Mutat. Res. J33 (2/3): 187-92 (December 1975) Actinomycin D (Act D), used as an antineoplastic agent, as an inhibitor of DNA-dependent RNA and protein synthesis, has been reported as a potent teratogen, a carcinogen, and a mutagen. In this study, Act D induced purple adenine-requiring mutants (ad_-3) in wild-type Neurospora crassa Average mutation frequency was 3.6/10° survivors. The spectrum of complementa- tion types closely resembles that of mutants induced by ICR-170, which induces base-pair insertions or deletions, or the spectrum of X ray-induced or spon- taneous mutants. The spectrum is quite different from that induced by nitrous acid or N-methyl-N'- nitro-N-nitrosoquanidine, which induce mostly base-pair substitutions. -394- ------- 39-0030 NITROSAMINES Liwerant, Irene Joab and Da Silva, Luiz H. Pereira COMPARATIVE MUTAGENIC EFFECTS OF ETHYL METHANESULFONATE, N-METHYL-N'-NITRO- N-NITROSOGUANIDINE, ULTRAVIOLET RADIATION AND CAFFEINE ON DICTYOSTELIUM DISCOIDEUM Mutat. Res. 33 (2/3): 135-46 (December 1975) The frequency of morphogenetlc mutants induced by N-methyl-N'-nitrosoguanadine (MNNG), ethyl methanesulfonate (EMS), UV radiation, and caffeine on the cellular slime mold _D. discoideum are reported. MNNG was the most efficient mutagenic agent of those tested, inducing a high frequency of morphogenetic mutants with relatively low cell killing. -395- ------- 39-0031 GENERAL INFORMATION Anon MONSANTO PLANS TO STOP MAKING PCB's Chem. Eng. News 54_ (5): 4-5 (2 February 1976) Monsanto, the sole producer in the U.S. of polychlorinated biphenyls (PCBs), is phasing out of the business, producing now only about 40 million Ib/yr compared to 72 million in 1970. Presently produced PCBs are used only for closed electrical systems - transformers, capacitors, for example - for which use no satisfactory substitute yet exists. Despite slow down in production, PCB contamination of fish and wildlife seems to be on the increase, and Monsanto plans eventually to stop production completely. 39-0032 GENERAL INFORMATION Anon ELECTRIC POWER FROM SPACE PROPOSED Chem. Eng. News 5^ (4) : 5 (26 January 1976) Satellite power stations to collect solar energy in space and return it to earth as microwave radiation were described by the Boeing Co. and by Arthur D. Little, Inc. to the Senate Subcommittee on Aerospace Technology & National Needs. Boeing claims its Powersat could yield up to 10,000 Mw of electrical energy but at an immense cost. The ADL solar power station at a cost of $7.6 billion could provide about 5000 Mw of usable electric power. -396- ------- 39-0033 GENERAL INFORMATION Kohn, Philip M. OCEAN THERMAL GRADIENTS BECKON ENERGY PLANNERS Chem. Eng. £3 (3) : 53-5 (2 February 1976) Use of the sea as a heat source and a heat sink for generating electricity may be one way of solving the energy crisis. Conceptual designs indicate that the concept could be cost-competitive even though a low thermal efficiency (only 5 to 8%) can be expected. One potential problem is that of biofouling of heat-transfer equipment in the open ocean. The method might be used more successfully as an adjunct to offshore chemical-process-industries plants. 39-0034 GENERAL INFORMATION Morton, Arthur R.. et al BIOLOGICAL EFFECTS OF TRINITROTOLUENE FROM EXPOSURE BELOW THE THRESHOLD LIMIT VALUE Am. Ind. Hyg. Assoc., J. 37. W : 56-60 (1976) This study shows that in an ammunition plant producing TNT workers exposed to TNT levels of 0.8 mg/nr experienced altered taste, respiratory problems, and dermatitis. Medical tests showed 59% of the workers (23 out of 39) to have abnormal high lactic dehydrogenase and 9 of the workers to have abnormal high serum glutamic oxalacetic transaminase. Indications are that the 1.5 mg/m-^ recommended threshold limit value (TLV) of TNT is too high and that for proper worker protection the TLV probably should be 1.5 mg/m . -397- ------- 39-0035 GENEEAL INFORMATION Anon POLLUTANTS FROM A METROPOLITAN AREA CAN MARKEDLY AFFECT AIR QUALITY DOWNWIND... Chem. Eng. News 54^ (4): 18 (26 January 1976) From a study of atmospheric data from Northern New Jersey, eastern New York, Connecticut, and Massachusetts, Bell Telephone Labs reports that excessive ozone concentrations in Fitchburg, Mass, result from photochemical air pollution in the NYC area, a distance of more than 200 miles. 39-0036 GENERAL INFORMATION Anon ANOTHER KEPONE LAWSUIT Chem. Week 118 (4): 14-5 (28 January 1976) Some 120 James River commercial fisherman are now suing Allied Chemical, Hooker Chemicals & Plastics, Life Science Products and Wm. F. Moore, Jr., former ex- ecutive of Life Science Products, the one-time manufacturer of Kepone. The fisherman claim economic losses and damages resulting from their inability to fish the river and its tributaries since Kepone waste has affected all the marine life there. -398- ------- 39-0037 GENERAL INFORMATION Anon SENATE PANEL PROBES KEPONE DISASTER Chem. Eng. News 54_ (5): 17-8 (2 February 1976) In the continuing Kepone saga, former employees of Life Science Products and executives of that now-defunct company and of Allied Chemicals testified before a Senate committee probing for the reasons behind the apparent lack of control of plant operations and the resulting health and environmental ill effects. 39-0038 GENERAL INFORMATION Anon KEPONE CAUSES LIVER CANCER IN MICE AND RATS Chem. Eng. News 54_ (5): 19 (2 February 1976) Unpublished results of NCI tests show that Kepone induced liver cancer in 81% of male mice and 52% of female mice, when fed to the mice in either low or high doses. A smaller percentage of rats developed liver cancer also, but only from high doses of Kepone. As with workers exposed to the pesticide, the animals also developed tremors. -399- ------- 39-0039 GENERAL INFORMATION Crockett, Pernell W. ENVIRONMENTAL CARCINOGENS (A BIBLIOGRAPHY WITH ABSTRACTS). NTIS/PS-75/844 (November 1975) The bibliography cites research reports on the identification, sources, and toxicity of environmental carcinogens. Included are data on pesticides, fire extinguishing agents, environmental pollutants, and food additives. (Contains 158 abstracts) [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p.47 (19 January 1976)] 39-0040 GENERAL INFORMATION Anon SCIENTIFIC AND TECHNICAL ASSESSMENT REPORT ON CADMIUM PB-246 820. EPA/600/6-75/003 (July 1975) The report is a review and evaluation of the current knowledge of cadmium in the environment as related to possible deleterious effects on human health and welfare. Sources, distribution, measurement, and control technology are also considered. Cadmium is widely distributed in the environment. The air over urban areas has contained generally less than 0.1 microgram per cubic meter, 24-hour average, but a 24-hour average as high as 0.73 microgram/cu m has been measured in the air of a community with a known cadmium source. The cadmium content of water generally is less than 1 part per billion although much higher values have been found. The cadmium content in foods varies widely. The estimated intake from foods is 25 to 75 micrograms per day. Food and tobacco smoke are the major sources except in the immediate vicinity of major sources of atmospheric emissions of cadmium. Emphysema and other lung diseases have been related to industrial exposure. Kidney damage has also resulted from long-term exposure to cadmium. Animal experiments link anemia, hypertension, testicular necrosis, and carcinogenesis with cadmium exposure. [Abstract in: NTIS Weekly Government Abstracts, Medicine and Biology, p.77 (26 January 1976)] -400- ------- 39-0041 GENERAL INFORMATION Anon FDA HAS BANNED THE USE OF DYE RED NO. 2 Chem. Eng. News 5_4 (4) : 7 (26 January 1976) Effective immediately, Red Dye No. 2 can no longer be used to color foods, drugs or cosmetics. FDA issued the ban on the basis of a study that "suggests" that the dye is a "weak carcinogen". As of 1973, U.S. sales of the dye were about 1.1 million Ib, worth $2.9 million. -401- ------- |