&EPA
United Stain
Environmental Protection
Agency
Of (tea of Pesticides and
Toxic Substances
Washington. DC 20460
- r a SK) • 8' 008
July 19B'
Toxic Substances
Environmental and
Health Aspects of
Adipate Esters
A Comprehensive
Bibliography of Published
Literature
1930 - 1981
-------
V-/EPA
United States
Environmental Protection
Agency
Office of Pesticides and
Toxic Substances
Washington, DC 20460
EPA 68-01-6021 Rept A
July 1981
Toxic Substances
Environmental and
Health Aspects of
Adi pate Esters
A Comprehensive
Bibliography of Published
Literature
1930- 1981
-------
50272-101
REPORT DOCUMENTATION ,.i._REPORT NO.
PAGE I EPA 560/7-81-008
3. Recipient's Accession No.
4. mi. .no SUM*..
and Health Aspects of selected
: Esters, A..Cqrrprehensive. Bibliography of Published
Literature 1930-1981
5. Report O.te prepared
June 1981
7. Author(s)
8. Performing Organization Rept. No.
9. Performing Organization Name and Address
Tracer Jitco, Inc.
1776 East Jefferson Street
Rockville, Maryland 20852
10. Project/Task/Work Unit No.
Technical Directive 7
11. Contract(C) or Grant(Q) No.
(C) 68-01-5836
(G)
12. Sponsoring Organization Name and Address
13. Type of Report & Period Covered
Environmental Protection Agency, Office of Pesticides and
Toxic Substances, Management Support Division, 401 M Street SW,
Washington, D.C. 20460
Final Report
1930-1981
14.
IS. Supplementary Notes
16. Abstract (Limit: 200 words.)
This document is a bibliography of published citations on health and
environmental aspects of selected Adipic acid esters ( Di-(2-ethylhexyl);
Di-n-octyl; Di-2-butoxyethyl; Diisodecyl; Diisooctyl; N-hexyl-n-decyl;
Di-(2-butoxyethyl)ethyl; N-octyl-n-decyl; Dimethyl; Dinonyl; C7-C9 linear;
Dicapryl; Diisopropyl; Ditridecyl; Chemical Abstracts Service Registry
Numbers 103-23-1; 123-79-5; 141-18-4; 27178-16-1; 1330-86-5; 22707-35-3;
141-17-3; 110-29-2; 627-93-0; 151-32-6; 68515-75-3; 108-63-4; 6938-94-9;
16958-92-2 respectively) for the period 1930 to May 1981. The citations
have been selected from a thorough literature search, and broadly class-
ified as having primarily environmental or biological emphasis. The
sources used in the search are identified, and for the portion performed
on line, the search strategies are also included.
17. Document Analysis a. Descriptors
Bibliographies; Literature Surveys; Environments; Public Health; Pollution;
Toxicology.
b. Identlfiers/Ooen-Ended Terms
Literature Search; Literature Review; Health Effects; Environmental
Effects; 103-23-1; 123-79-5; 141-18-4; 27178-16-1; 1330-86-5; 22707-35-3;
141-17-3; 110-29-2; 627-93-0; 151-32-6; 68515-75-3; 108-63-4; 6938-94-9;
16958-92-2
c. COSATI Field/Group
IS. Availability Statement
Release unlimited
19. Security Class (This Report)
Unclassified
20. Security Class (This Page)
Unclassified
21. No. of Pages
22. Price
(See ANSI-Z39.18)
See Instructions on Reverse
OPTIONAL FORM 272 (4-77)
(Formerly NTIS-35)
Department of Commerce
-------
OIS-HC REPORT FILE
EPA Report No. 560/7-81-008
July 1981
ENVIRONMENTAL AND HEALTH
ASPECTS OF ADIPATE ESTERS
A Comprehensive Bibliography
of Published Literature
1930 - 1981
by
Management Support Division
Information Support Services Branch
Office of Toxic Substances
Washington, D.C. 20460
68-06-5836
Project Officers
Michael Weaver, Delores Evans
Management Support Division
Office of Toxic Substances
Washington, D.C. 20460
OFFICE OF TOXIC SUBSTANCES
U.S. ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, D.C. 20026
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Preface
This bibliography was created from a literature search performed under
the auspices of the Management Support Division, Information Support Services
Branch for the Assessment Division, Chemical Review and Evaluation Branch;
both of the Office of Toxic Substances. The search was intended to provide
partial support for the preparation of a Preliminary Risk Assessment on
adipate esters: di(2-Ethylhexyl) adipate, di-n-octyl adipate,
di(2-butoxyethyl)adipate, diisodecyl adipate, diisooctyl adipate, n-Hexyl
n-decyl adipate, di butoxyethyl adipate, dimethyl adipate, dinonyl adipate,
adipic acid dialkyl (C7-C9) ester, 2-methylheptyl adipate, diisopropyl
adipate, and ditridecyl adipate. This assessment reviews and evaluates the
available significant economic and adverse effects data from both published
and unpublished sources on a substance selected as being potentially hazardous
to human health or the environment.
The subject coverage of the assessment is broader than this bibliography
which includes only published environmental and biological information. The
bibliography does not include all information available to the review branch.
Although it is not an authoritative source list for Preliminary Risk
Assessments, it does represent a comprehensive and systematic search of the
literature and subsequent selection of citations that pertain to health and
the environment. The limits of the search are fully described in this
document and its appendices.
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Introduction
1. The Search
This bibliography is a compilation of citations retrieved during a
thorough review of the national and international literature on selected
adipate esters cited between 1930 and April 1980.
The supporting search was performed at the request of the Assessment
Division/Chemical Review and Evaluation Branch by the Management Support
Division/Information Support Services Branch, within the Office of Toxic
Substances.
To insure that the search was comprehensive, a variety of sources were
examined, including the following:
o On-line databases from major vendors of bibliographic information.
o On-line databases from various agencies of the United States
Government.
o Manually searched national and international indices and abstract
collections of scientific literature.
o Reference sections of major review articles, criteria documents,
monographs, and reports.
o Selected handbooks.
(A complete listing of sources consulted can be found in Appendices I
and II).
The emphasis of this bibliography is on the primary literature except
for the handbook information presented in Section II and a few secondary
sources selected because they contain unique or well-summarized information on
the chemical.
Subsequent to the main search, which was completed in April 1980, and
using the same strategy, update searches were performed during the period from
April 1980 to May 1981 on all the on-line databases initially searched. In
addition, the April 1981 and May 1981 issues of Current Contents (Life
Sciences, Agriculture, Biology, and Environmental Sciences series) were
screened to retrieve citations which may not have been entered into the
on-line files at the time of the final update searches.
-------
Because the overall requirement of the search request for this project
was broader than the health and environmental aspects of the chemical, a wider
range of databases was searched than might normally be expected for this
bibliography. However, only health and environmental aspects were selected
regardless of the data source examined. The total complement of databases
searched is listed in the appendices for the user's reference.
1.2. Strategy
The search requirement demanded high recall of information dealing with
adipate esters; precision was a secondary consideration. EPA decided to
retrieve all citations that contained the term adipate ester or its synonyms
in any searchable fields and to select relevant citations by a manual screen.
The Chemical Abstract Service registry numbers (CAS RN) and systematic names
and synonyms that could be identified from CHEMLINE (National Library of
Medicine); CHEMDEX (System Development Corporation); CHEMNAME, CHEMSEARCH, and
CHEMSIS (Lockheed Information System); SANSS (NIH/EPA Chemical Information
System); and RTECS (NIOSH Registry of Toxic Effects of Chemical Substances)
were used in the search on databases. For on-line searching, the names were
divided into significant fragments and entered according to the conventions of
the individual databases.
No additional modifiers or keywords were used to limit information
retrieved in any database for this chemical because comprehensive retrieval
was desired. Complete search strategies are listed in Appendix II.
Use/application categories were not used as search terms because EPA
decided to select only terms that specifically mentioned the chemical or its
synonyms. Indexing policy, keyword entry, and abstracting techniques usually
assure retrieval of specific information on individual chemicals if they are
discussed significantly in general articles or reviews. The user can be
assured; therefore, that each citation listed in this bibliography contains
substantive information on the subject chemical.
Manual sources, indices, and abstract collections usually employ their
own unique indexing schemes for chemical information, so it is difficult to
describe a standard search strategy for these information tools. However, in
all cases, the most specific indexing terms available in the source were used
to identify citations on the subject chemical.
Chemical terms used in this search are found on Table I.
111
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Table I
Chemical #1
RN - 103-23-1
MF - C22-H42-04
Nl - Adipic acid, bis(2-ethylhexyl)ester (8CI)
Nl - Hexanedioic acid, bis(2-ethylhexyl)ester (9CI)
SY - Adipate, Bis(2-ethylhexyl)
SY - Adipate, Dioctyl
SY - Adipate, Octyl
SY - Adipol 2EH
SY - Bis (2-ethylhexyl)adipate
SY - Bisoflex DOA
SY - Di(2-Ethylhexyl)adipate
SY - Dioctyl adipate
SY - DOA
SY - Effomoll DOA
SY - Ergoplast AdDO
SY - Flexol
SY - Kodaflex DOA
SY - Monaplex DOA
SY - Octyl Adipate
SY - Plastomoll DOA
SY - Sicol 250
SY - Truflex DOA
SY - Vestinol OA
SY - Wickenol 158
SY - Witamol 320
Chemical #2
RN - 123-79-5
MF - C22-H42-04
Nl - Adipic acid, dioctyl ester (8CI)
Nl - Hexanedioic acid, dioctyl ester (9CI)
SY - Adinoll SO
SY - Adipate, Di-n-octyl
SY - Adipate, Dioctyl
IV
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Table I (Cont'd)
Chemical #2 (Cont'd)
SY - Adipate, Octyl
SY - Di-n-octyl adipate
SY - Dioctyl adipate
SY - Octyl adipate
Chemical #3
RN - 141-18-4
MF - C18-H34-06
Nl - Adipic acid, bis(2-butoxyethyl) ester (8CI)
Nl - Hexanedioic acid, bis(2-butoxyethyl)ester (9CI)
SY - Adipate, Bis(butoxyethyl)
SY - Adipate, Bis(2-butoxyethyl)
SY - Adipate, BisCethylene glycol monobutyl ether)
SY - Adipate, Di(butoxyethyl)
SY - Adipate, Di(2-butoxyethyl)
SY - Adipic acid, bisCethylene glycolmonobutyl ether) ester
SY - Adipol BCA
SY - Bis(butoxyethyl) adipate
SY - Bis(2-butoxyethyl) adipate
SY - BisCethylene glycol monobutyl ether) adipate
SY - Di (butoxyetyl) adipate
SY - Di (2-butoxyethyl) adipate
SY - Staflex DBEA
Chemical #4
RN - 27178-16-1
MF - C26-H50-04
Nl - Adipic acid, diisodecyl ester (8CI)
Nl - Hexanedioic acid, diisodecyl ester (9CI)
SY - Adipate, Diisodecyl
SY - Adipate, Diisododecyl
SY - Adipate, Isodecyl
SY - DIDA
SY - Diisodecyl adipate
-------
Table I (Cont'd)
Chemical #4 (Cont'd)
SY - Diisododecyl adipate
SY.,- Isodecyladipate
SY - Plastomoll DIDA
SY - Vinicizer 50
SY - Witamol 380
Chemical #5
RN - 1330-86-5
MF - C22-H42-04
Nl - Adipic acid, diisooctyl ester (8CI)
Nl - Hexanedioic acid, diisooctyl ester (9CI)
SY - Adipate, Diisooctyl
SY - Adipate, Isooctyl
SY - Adipol 10A
SY - Diisooctyl adipate
SY - DIOA
SY - Isooctyl adipate
SY - PX 208
Chemical #6
RN - 22707-35-3
MF - C22-H42-04
Nl - Adipic acid, Decyl hexyl ester (8CI)
Nl - Hexanedioic acid, Decyl hexyl ester (9CI)
SY - n-Hexyl n-decyl adipate
Chemical #7
RN - 141-17-3
MF - C22-H42-08
Nl - Adipic acid, bis (2-(2-butoxyethoxy)ethyl) ester (8CI)
Nl - Hexanedioic acid, bis(2-(2-butoxyethoxy)ethyl) ester (9CI)
SY - Adipate, Bis(2-(2-butoxyethoxy)ethyl
SY - Adipate, Bis (diethylene glycol monobutyl ether)
VI
-------
Table I (Cont'd)
Chemical #7 (Cont'd)
SY - Adipate, Dibutoxyethoxy ethyl
SY - Adipic acid, bis (diethylene glycol monobutyl ether) ester
SY - Bis(2-(2-butoxyethoxy)ethyl) adipate ester
SY - Bis (diethylene glycol monobutyl ether) adipate ester
SY - Dibutoxyethyl adipate
Chemical #8
RN - 110-29-2
MF - C24-H46-04
Nl - Adipic acid, decyl octyl ester (8CI)
SY - Adipate, Decyl octyl
SY - Adipate, n-Decyl n-octyl
SY - Adipate, Octyl decyl
SY - Adipate, n-Octyl n-decyl
SY - Adipol ODY
SY - Decyl octyl adipate
SY - n-Decyl n-Octyl adipate
SY - Hercoflex
SY - Monoplex NODA
SY - Octyl decyl adipate
SY - n-Octyl decyl adipate
SY - PX-202
SY - Staflex NODA
SY - Truflex 146
Chemical
RN - 627-93-0
MF - C8-H14-04
Nl - Adipic acid, dimethyl ester (8CI)
Nl - Hexanedioic acid, dimethyl ester (9CI)
SY - Adipate, Dimethyl
SY - Adipate, Methyl
SY - Dimethyl adipate
VII
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Table I (Cont'd)
Chemical #9 (Cont'd)
SY - Dimethyl hexanedioate
SY - Hexanedioate, Dimethyl
SY - Methyl adipate
Chemical #10
RN - 151-32-6
MF - C24-H46-04
Nl - Adipic acid, dinonyl ester (8CI)
Nl - Hexanedioic acid, Dinonyl ester (9CI)
SY - Adimoll DN
SY - Adipate, Di-n-nonyl
SY - Bisoflex DNA
SY - Dinonyl adipate
SY - Plastomoll Na
Chemical #11
RN - 68515-75-3
MF - Unknown
SY - Adipic acid, diakyl (C7 - C9) ester
SY - Hexandeioic acid, bis(branched and linear C-7-9-alkyl) ester
SY - C7 - C9 Adipate
Chemical #12
RN - 108-63-4
MF - C22-H42-04
Nl - Adipic acid, bis(l-methylheptyl) ester (8Cl)
Nl - Hexanedioic acid, bis(l-methylheptyl) ester (9CI)
SY - 2-Methylheptyl adipate
Vlll
-------
Table I (Cont'd)
Chemical #13
RN - 6938-94-9
MF - C12-H22-04
Nl - Adipic acid, diisopropyl ester (8CI)
Nl - Hexanedioic acid, bis(l-methylethyl) ester (9CI)
SY - Adipate, Diisopropyl
SY - Adipate, Isopropyl
SY - Ceraphyl 230
SY - Diisopropyl adipate
SY - Isopropyl adipate
SY - Staudanol DIPA
SY - Wickenol 116
Chemical #14
RN - 16958-92-2
MF - C32-H62-04
Nl - Adipic acid, ditridecyl ester (8CI)
Nl - Hexanedioic acid, ditridecyl ester (9CI)
SY - Adipate, Bis(tridecyl)
SY - Adipate, Ditridecyl
SY - Bis (tridecyl) adipate
SY - Ditridecyl adipate
IX
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1.3. Selection of Citations
Citations were selected for inclusion in this bibliography based on
their relevance to the following topics:
o Toxicity — Adverse and toxic effects on any biological systems,
structural and functional changes in organs and tissues of all
vertebrate and invertebrate species, test methods used for
determination of toxicity, and bioassay studies.
o Physiology — Absorption, distribution, transport, metabolism,
and elimination in all species; techniques for measurement of
tissue and organ residues; interactions with endogenous
substances.
o Epidemiology — Exposure data, morbidity, and mortality rates for
general and occupational populations.
o Environmental Significance — Environmental distribution in air,
soil, and water; sources of pollution; ecological effects on
microorganisms, insects, plants, and wildlife; biodegradation and
bioconcentration; analytical techniques for sampling and
measurement in the environment.
o Safety, Control, and Regulations — Disposal hazards; Federal,
local, and international controls, recommendations, and
regulations.
These are the broad specifications for inclusion in this
bibliography. Because any literature selection process involves
subjectivity and judgement, precise definitions are difficult. The
general guiding requirement for inclusion is that citations must pertain
to the biological or environmental aspects of the chemical.
The following information is not included in this bibliography:
news items; brief announcements and Federal Register notices;
reports of on-going research which have not yet been published or
any other unpublished information; draft reports; and private
communications.
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2. Organization of Bibliography
This bibliography is organized into three major sections.
2.1. Section Titles
Section I — Handbook information
Section II — Citations from the primary literature
Section III — Appendices listing specific sources used and exact
search strategies employed
2.2. Citation Format
In Section II citations from on-line and manually searched abstract
collections are arranged alphabetically by author.
Personal names are entered with the last name first followed by the
first two initials. Second and third authors' names are separated from the
first author and each other by a semicolon. Up to three personal names are
used; if there are more than three authors, the remaining are listed as
"et al."
If an author has written more than one article, citations are arranged
in ascending chronological order. If authors and date are identical,
citations are arranged alphabetically by title of the article. Single author
entries are listed first, followed by two, then three author entries.
Patents are arranged alphabetically by assignee name.
All government publications are listed by the sponsoring government
agency. Government or corporate names are written in full form. No acronyms
are used. The country of origin is listed first, followed by the
organizational hierarchy of the sponsoring group listed in descending
hierarchical order. If the performing organization or individual author is
known, they are listed on separate lines below the government sponsor.
Example: NIOSH publication:
United States. Department of Health, Education and Welfare. Public
Health Service. Center for Disease Control. National Institute for
Occupational Safety and Health
Tracer Jitco, Inc.
Brown, R.A.; Smith S.S.
Corporate documents with no specific author are listed in alphabetical
order according to the first significant word of the organization name.
e.g., DuPont de Nemours, E.I. and Company
XI
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2.3. Literature Cited
The following kinds of literature are cited in this bibliography:
journal articles, government reports, patents, organization and corporate
reports, books, manufacturer's literature, conference proceedings, and
dissertations.
In each case an attempt has been made to supply the user with enough
information so that the hard copy of the document may be easily obtained.
Journal titles are abbreviated according to the style in the Chemical
Abstracts Service Source Index (CASSl), The American Chemical Society,
Columbus, OH, 1980 and its corresponding guide, Bibliographic Guide for
Editors and Authors, The American Chemical Society, Washington, DC, 1974.
All foreign titles have been translated into English. Foreign language
articles are indicated by the appropriate three letter language abbreviation
in parentheses at the end of the source information.
2.4. Categorization of Citations
In order to make this bibliography a more useful tool for separate user
groups, most citations are marked with the category code E or H.
E = Environmental Aspects, i.e., the major content of the document
pertains to the chemical in the open environment: its distribution,
degradation, environmental chemistry and analysis; effect on
ecosystems; effect on flora and fauna, including laboratory research,
when emphasis is on environmental considerations rather than
prediction of human effects, environmental chemistry, and analysis.
H = Health Aspects, i.e., the major content of the document concerns
known health effects, predictive laboratory research, and animal
studies as relates to human health effects, human exposure, and
epidemiological studies.
A decision was made based on the abstract, and in some cases the entire
document, to categorize according to what appeared to be the major purpose of
the study. In a few cases neither category applies. Those citations were
left unclassified.
XI1
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HANDBOOK
AND
DATABANK
INFORMATION
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3. Handbook and Databank Information
3.1. Summary Databanks for Health Effects Data (information found)
United States. Department of Health and Human
Services. Public Health Service. Center for Disease yes
Control. National Institute for Occupational
Safety and Health
Registry of Toxic Effects of Chemical Substances.
Cincinnati, OH: NIOSH, 1980
United States. Department of Health and Human
Services. Public Health Service. National
Institutes of Health. National Library of Medicine yes
Toxicology Data Bank.
Bethesda, MD 1980
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3.2. Handbooks Searched for Health Effects
Source
Location of Information
Browning, E.
Toxicity and Metabolism of Industrial Solvents.
New York: Elsevier Publishing Co., 1963
No pertinent
information
Browning, E.
Toxicity of Industrial Metals.
New York: Appleton-Century-Crofts, 1969
No pertinent
information
Dittmer, D.S., Editor
Handbook of Toxicology, V. - Fungicides.
Philadelphia: W. B. Saunders Company, 1959
No pertinent
information
Fishbein, L.
Potenial Industrial Carcinogens and Mutagens.
New York: Elsevier Scientific Publishing Co., 1979
pp. 477-8
Fishbein, L.; Flamm, W.G.; Falk, H.L.
Chemical Mutagens.
New York: Academic Press, 1970
No pertinent
information
Goodman, L.S.; Oilman, A., Editors
The Pharmacological Basis of Therapeutics.
New York: Macmillan Publishing Co., Inc., 1975
No pertinent
information
Patty, F.A., Editor
Industrial Hygiene and Toxicology.
New York: Interscience Publishers, 1963
Chemical #1:
pp. 1881-3,
1890-1
Chemical #3:
pp. 1881-2,
1890-1
Chemical #5:
p. 1881
Plunkett, E.R.
Handbook of Industrial Toxicology.
New York: Chemical Publishing Co., Inc., 1976
No pertinent
information
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3.2. Handbooks Searched for Health Effects (cont'd)
Source
Sax, N.I.
Dangerous Properties of Industrial Materials.
New York: Van Nostrand Reinhold Co., 1979
Location of Information
Chemical #1:
pp. 578, 620
Chemical #2:
p. 620
Chemicals #4,5:
p. 591
Searle, C.E., Editor
Chemical Carcinogens.
Washington, DC: American Chemical Society, 1976
No pertinent
information
Shepard, T.H.
Catalog of Teratogenic Agents.
Baltimore, MD: The Johns Hopkins University
Press, 1976
No pertinent
information
Spector, W.S., Editor
Handbook of Toxicology, V. I. - Acute Toxicities,
Philadelphia: W. B. Saunders Company, 1956
No pertinent
information
Spector, W.S., Editor
Handbook of Toxicology, V. II. - Antibiotics.
Philadelphia: W.B. Saunders Company, 1957
No pertinent
information
Spector, W.S., Editor
Handbook of Toxicology, V. III. - Insecticides
Philadelphia: W.B. Saunders Company, 1959
No pertinent
information
Sunshine, I., Editor
CRC Handbook Series in Analytical Toxicology.
Boca Raton, FL: CRC Press, Inc., 1979
No pertinent
information
United Nations. International Agency for Research on
Cancer
IARC Monographs on the Evaluation of the Carcinogenic
Risk of Chemicals to Humans.
Lyon, France: IARC
No pertinent
information
-------
3.2. Handbooks Searched for Health Effects (cont'd)
Source
United States. Department of Health and Human
Services. Public Health Service. Center for
Disease Control. National Institute for
Occupational Safety and Health
NIOSH Criteria Documents.
Cincinnati, OH: NIOSH
Location of Information
No pertinent
information
United States. Department of Health and Human
Services. Public Health Service. National Institutes
of Health. National Cancer Institute
NCI Carcinogens Bioassay Reports.
Springfield, VA: National Technical Information
Service
Chemicals
13:
p. 69
United States. Department of Health and Human
Services. Public Health Service. National Institutes
of Health. National Cancer Institute
Survey of Compounds Which Have Been Tested for
Carcinogenic Activity.
Bethesda, MD: NCI, 1978
No pertinent
information
United States. Environmental Protection Agency
EPA Publications Bibliography.
Washington, DC, EPA
No pertinent
information
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3.3. Handbooks Searched for Environmental Effects
Source Location of Information
Applegate, V.C.; Howell, J.H.; Hall, A.E.; et al. No pertinent
Toxicity of 4,346 Chemicals to Larval Lampreys' and information
Fishes: Special Scientific Report.
Fisheries No. 207, Washington, DC, 1957
McKee, J.E.; Wolf, H.W., Editors No pertinent
Water Quality Criteria, 2nd Edition. information
California State Water Resources Control Board, 1963
Ryckman, D.W.; Prabhakara Rao, A.V.S.; Buzzel, J.C. No pertinent
Behavior of Organic Chemicals in the Aquatic information
Environment.
Washington, DC: Manufacturing Chemists' Association,
1966
United States. Environmental Protection Agency No pertinent
Review of the Environmental Fate of Selected Chemicals. information
Springfield, VA: National Technical Information
Service, 1977
United States. Environmental Protection Agency No pertinent
Review of the Environmental Fate of 129 Priority information
Pollutants.
Springfield, VA: National Technical Information
Service, 1977
Verschueren, K. No pertinent
Handbook of Environmental Data on Organic Chemicals. information
New York: Van Nostrand Reinhold Co., 1977
-------
3.4. Handbooks Searched for Physical and Chemical Properties
Source
Aldrich Chemical Company, Inc.
Aldrich Catalog Handbook of Fine Chemicals. 1981-2.
Milwaukee, WI: Aldrich Chemical Co., 1980
Location of Information
Chemical #9:
p. 371
Bennet, H., Editor
Concise Chemical and Technical Dictionary.
New York: Chemical Publishing Co., Inc., 1974
Chemicals #1,2:
p. 380
Chemical #8:
p. 765
Chemical #9:
p. 366
Dreisback, R.R.
Physical Properties of Chemical Compounds.
Washington, DC: American Chemical Society, 1959
No pertinent
information
Grasselli, J.G.; Ritchey, W.M., Editors
CRC Atlas of Spectral Data and Physical Constants
for Organic Compounds.
Boca Raton, FL: CRC Press, 1975
Chemical #1:
Vol. Ill, p.437
Chemical #3:
Vol. Ill, p.436
Chemicals #2,9:
p. 439
Grayson, M., Editor
Kirk-Othmer Encyclopedia of Chemical Technology.
New York: Interscience Publishers, 1979
Chemicals #1,2,
3,4,5,7,8,9,11,
13, 14:
Vol. I, p.524-8
Hawley, G.G.
The Condensed Chemical Dictionary.
New York: Van Nostrand Reinhold Co., 1977
Chemical #1:
pp. 17,290,313
Chemical #3:
p. 273
Chemical #4:
p. 299
Chemical #5:
pp. 299, 481
Chemical #8:
p. 633
Chemical #10:
p. 313
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3.4. Handbooks Searched for Physical and Chemical Properties (cont'd)
Source
Kortum, G.; Vogel, W.
Dissociation Constants of Organic Acids in Aqueous
Solution.
London: Butterworths, 1961
Location of Information
No pertinent
information
Leo, A.; Hansch, C.; Elkins, D.
Chemical Reviews.
Claremont, CA: Department of Chemistry, Pomona
College, 1971
No pertinent
information
Linke, W.F.
Solubilities of Inorganic and Metal-Organic Compounds.
New York: D. Van Nostrand Co., Vol. I. 1958, Vol. II. 1965
Mark, H.F.; Gaylord, N.G.; Bikales, N.M., Editors
Encyclopedia of Polymer Science and Technology.
New York: Interscience Publishers, 1964
No pertinent
information
Chemicals #2,5,
9,10,13:
Vol. I, p.116
Chemicals #1,3,
4,8:
Vol. I, p. 253
Chemical #1:
Vol. I, p. 269
Perry, R.H.; Chilton, C.H., Editors
Chemical Engineers Handbook.
New York: McGraw-Hill Book Co., 1973
Pollock, J.R.; Stevens, R., Editors
Dictionary of Organic Compounds.
London: Eyre and Spottiswoode Publishers, Ltd., 1965
No pertinent
information
Chemicals #2,9,
10,13
pp. 45-6
Stephen, H.; Stephen, T.; Editors
Solubilities of Inorganic and Organic Compounds.
New York: The Macmillan Co., 1963
No pertinent
information
Weast, R.C., Editor
CRC Handbook of Chemistry and Physics.
Boca Raton, FL: CRC Press, 1979
Chemicals #9,
13:
p. C-82
Windholz, M., Editor
The Merck Index.
Rahway, NJ: Merck and Co., Inc., 1976
No pertinent
information
-------
CITATIONS
FROM THE
LITERATURE
-------
Akagi, H.; Kobayashi, A.
Analysis of Plasticizers and Hydrogen Chloride during Processing
of Polyvinyl Chloride Compounds.(Di-n-octyl Adipate)
Proceedings: 16th National Air Pollution Research Conference.
Paper 121. Niigata, Japan, Nov. 5-7, 1975.
J. Japan. Soc. Air Pollut., 10(4):374 (1975) (Jpn)
Altmeyer, P.; Zaun, H.
H " Results of Reflexphotometric Determination of Vasoconstriction
after Topical Application of Steroids. II. Influence of
Solvents.(Diisopropyl Adipate)
Arch. Dermatol. Forsch, 248(4):387-90 (1974) (Ger)
American Medical Association
H DEHA. (Di-(2-ethylhexyl) Adipate)
Arch. Ind. Hyg. Occup. Med., 4:119 (1951)
Andreeva, G.A.
H Toxicology of the Plasticizer Dioctyl Adipate. (Di-n-octyl
Adipate)
Gig. Primen. Toksikol. Pestits. Klin. Otravlenii, 9:373-7 (1971)
(Rus)
Andreeva, G.A.
Problem of Migration of Chemical Substances from Poly (Vinyl
Chloride) Materials Plasticized with Dioctyl Adipate.
(Di-(Z-ethylhexyl) Adipate)
Gig. Primen. Polim. Mater Stroit, pp. 77-8 (1973) (Rus)
Ref. Zh. Khim. 1973, Abstr. No. 241612
Asahi Dow, Ltd.
Yokochi, T.
H Antioxidant Composition. (Di-(2-ethylhexyl) Adipate)
Japan, Patent No. 76 52445
Nov. 2, 1974
BASF A.-G.
Suter, H.} Berger, R.; Bipp, H., et al.
Continuous Manufacture of Dicarboxylates with Waste Water
Treatment(Di-(2-ethylhexyl) Adipate)
Germany, Patent No. 2230226
Jun. 21, 1972
11
-------
Bleehen, T.
H The Effect of Plasticizers on Responses Mediated by
Cholinoceptors at the Neuromascular Junction.
Br. J. Pharmacol., 66(1):76 (May 1979)
Bloom, P.J.
Application of Thin-Layer and Gas-Liquid Chromatography to the
Qualitative and Quantitative Analysis of Aliphatic Dicarboxylic
Acid Esters.(Di-(2-ethylhexyl) Adipate, Dimethyl Adipate,
Di-n-octyl Adipate)
J. Chromatogr., 115(2):571-80 (1975) (Fre)
Bochkareva, G.G.; Ovchinnikov, Y.V.; Kurganova, L.N.; et al.
E Degradation of Plasticizers of PVC by Molds. (Di-(2-ethylhexyl)
Adipate)
Plast. Massy, (6):71-2 (1976) (Rus)
Bochkareva, G.G.; Ovchinnikov, Y.V.; Rurganova, L.N.; et al.
E Study of the Fungal Resistance of Plasticized Poly(Vinyl
ChlorideTI(Di-n-octyl Adipate)
Biopovrezhdeniya Mater. Zashch. Nikh :151-3 (1978) (Rus)
Boullenger, Y.
E Constant-Release Insecticides. (Diisooctyl Adipate)
France, Patent No. 2077679
Feb. 4, 1970
Brown, S.L.; Chan, F.Y.; Jones, J.L.; et al.
H Research Program on Hazard Priority Ranking of Manufactured
Chemicals (Chemicals 41-6(TT(Di-(2-ethylhexyl) Adipate)
U.S. NTIS, PB-263163, 191 pp. (1975)
Ciba-Geigy, A.-G.
Hennart, C.; Roth, W.; Moldovanyi, L.
E Water-Resistant Organsphosphate Insecticidal Preparations.
(Di-(2-ethlyhexyl) Adipate)
Luxemburg, Patent No. 2091953
Jan. 9, 1970
Ciba-Geigy, A.-G.
Dulat, M.L.; Hennart, C.
E Insecticide Preparations Based on Carbamic Acid Esters.
(Di-(2-ethylhexyl) Adipate)
Luxemburg, Patent No. 2250604
Oct. 18, 1971
Colgate-Palmolive Company
Shumway, D. K.; Marschner, F. W.
H Aerosol Deodorant. (Diisopropyl Adipate)
United States, Patent No. 2524695
Jun. 12, 1974
12
-------
Cook, W.A.
H Industrial Hygiene Evaluation of Thermal Degradation Products
Trom PVC Film in Meat-wrapping Operations. (Di-(2-ethylhexyl)
Adipate)
Am. Ind. Hyg. Assoc. J., 41(7):508-12 (1980)
Dauh, H.; Gilbert, S.G.
H Migration of Plasticizers from Polyvinyl Chloride Packaging
Films to Meat.(Di-(2-ethylhexyl) Adipate)
J. Fd. Sci., 42(2):561-2 (1977)
Duteil, J.; Nadaud, J.; Jtenry, M.; et al.
H Pharmacological Study of 4-(l-Naphthoxy)-3-hydroxybutyramidoxime
Hydrochloride (LL1530) Antiarrhythmic Effect.(Dimethyl Adipate)
Therapie, 28(4):703-20 (1973) (Fre)
Easterling, R.E.; Johnson, E.; Napier, E.A. Jr.
H Plasma Extraction of Plasticizers from Medical Grade
Polyvinylchloride Tubing.(Di-(2-ethylhexyl) Adipate)
Proc. Soc. Exp. Biol. Med., 147(2):572-4 (1974)
Eastman, Kodak Company
Touey, G.P.; Mumpower, R.C. 2nd
H Polyolein Cigaret Filter. (Di-n-octyl Adipate)
United States, Patent No. 3285255
Apr. 9, 1962
Eisele, T.A.; Yoss, J.K.; Nixon, J.F.; et al.
H Rat Urinary Metabolites of (9.10 Methylene 14C) Sterculic Acid.
Biochim. Biophys. Acta, 488(l):76-87 (1977)
Exxon Research and Engineering Company
Rutkowski, A.J.; Szykowski, J.P.
E Biodegradable Seal Swell Additive with Low Toxicity Properties
for Automatic Transmission Fluids, Power Transmission Fluids,
and Rotary Engine Oil Applications.(Di-(2-ethylhexyl) Adipate)
United States, Patent No. 3974081
Jul. 31, 1974
Fayz, S.; Herbert, R.; Martin, A.M.
H The Release of Plasticizer from Polyvinyl Chloride Hemodialysis
Tubing.(Di-(2-ethylhexyl) Adipate;
J. Pharm. Pharmacol., 29(7):401-10 (1977)
Ferretti, A.; Flanagan, V.P.
H Tissue Variation in Hydrocarbon Composition in the Rabbit.
. (Di-n-octyl Adipate)
Lipids, 12(2):198-203 (1977)
Gaunt, I.F.; Grasso, P.; Lansdown, A.B.; et al.
H Acute (Rat and Mouse) and Short-Term (Rat) Toxicity Studies on
Dialkyl-79-Adipate.
Food Cosmet. Toxicol., 7(1):35-46 (Jan. 1969)
13
-------
Griffith, S.M.; Schnitzer, M.
E Oxidative Degradation of Humic and Fulvic Acids Extracted from
Tropical Volcanic Soifs"^(Dimethyl Adipate)
Can. J. Soil. Sci., 55(3):251-67 (1975)
Griffith, S.M.; Schnitzer, M.
E Organic Compounds Formed by the Hydrogen Peroxide Oxidation of
Soils. (Di-n-octyl Adipate)
Can. J. Soil Sci., 7(3):223-31 (1977)
Hicks, 0.; Kaley, R.G. 2nd; Mieure, J.P.; et al.
E Activated Sludge Degradation of Adipic Acid Esters.
Appl. Environ. Microbiol., 31(5):746 (May 1976)
Kites, R.A.
E Analysis of Trace Organic Compounds in New England Rivers.
(Di-(2-ethylhexyl) Adipate)
J. Chromatogr. Sci., ll(ll):570-4 (1973)
Hites, R.A.
E Sources and Fates of Industrial Organic Chemicals; A Case
Study.(Di-(2-ethylhexyl) Adipate)
Symposium: 8th Meeting of the National Conference of Municipal
Sludge Management, pp. 107-19 (Pub. 1979)
Hites, R.A.; Jungclaus, G.A.; Lopez-Avila, V.; et al.
E Potentially Toxic Organic Compounds in Industrial Wastewaters
and River Systems; Two Case Studies.
Symposium: 174th Meeting of the American Chemical Society.
Chicago, IL, Aug. 31, 1977.
American Chemical Society Symposium Series No. 94. Monitoring
Toxic Substances. Edited by Schuetzle, D., pp. 63-90 (Pub. 1979)
Hodge, H.C.; Maynard, E.A.; Downs, W.L.; et al.
H Tests on Mice for Evaluating Carcinogenicity.
(Di-(2-ethylhexyl) Adipate, Di-n-octyl Adipate)
Toxicol. Appl. Pharmacol., 9(3):583-96 (1966)
Homrowski, S.
H Toxicity of Additives Used in the Production of Plastics. I.
Acute Toxicity of Some Stabilizers and Plasticizers.
(Di-n-octyl Adipate)
Rocz. Panstw. Zakl. Hig., 18(3):283-91 (1967) (Pol)
Hrudey, S.E.; Sergy, G.A.; Thackeray, T.
E Toxicity of Oil Sands Plant Waste Waters and Associated Organic
Contaminants.(Di-(2-ethylhexyl) Adipate)
Water. Pollut. Res. Can., 11:34-45 (1976)
Inden, T.; Tachibana, S.
E Damage on Crops by Gases Emitted from the Plastic Materials for
Covering^(Di-(2-ethylhexyl) Adipate, Diisodecyl Adipate)
Mie Daigaku Nogakubu Gakujutsu Hokoku, 50:1-10 (1975) (Jpn)
14
-------
I to, M.; Miyagawa, T.; Assayama, M.; et al.
H Solubility of Organic Compounds Used for Household Articles in
Human Sweat.(Di-(2-ethylhexyl) Adipate)
Aichi Ika Daigaku Igakkai Zasshi., 7(3):183-9 (1979).(Jpn)
Jacob!, 0.
H Skin Respiration and Cosmetics. (Di-(2-ethylhexyl) Adipate)
Amer. Perfum. Cosmet., 85(7):25-30 (1970)
Jacobson, M.S.
H Effect of a Plasticizer Leached from Polyvinyl Chloride on the
Subhuman Primate; A Consequence of Chronic Transfusion Therapy.
J. Lab. Clin. Med., 89(5):1066-79 (May 1977)
Jaeger, R.J.; Hites, R.A.
H Pyrolytic Evaporation of a Plasticizer from Polyvinyl Chloride
Meat Wrapping FilnT(Di-(2-ethylhexyl) Adipate)
Bull. Environ. Contain. Toxicol., ll(l):45-8 (Jan. 1974)
Jaeger, R.J.; Rubin, R.J.
H Extraction, Localization, and Metabolism of Di-2-ethylhexyl
Phthalate from PVC Plastic Medical Devices.(Di-(2-ethylhexyl)
Adipate)
Environ. Health Perspect., 3:95-102 (Jan. 1973)
Janardan, K.G.; Schaeffer, D.J.; Somani, S.M.
E Efficiencies of Liquid Liquid Extraction Carbon and XAD-2
Absorption in Isolating Organic Compounds from Environmental
Sources^(Di-(2-ethylhexyl) Adipate)
Bull. Environ. Contam. Toxicol., 24(1):145-51 (1980)
Jones, A.E.; Kahn, R.H.; Groves, J.T.; et al.
H Phthalate Ester Toxicity in Human Cell Cultures.
(Di-(2-ethylhexyl) Adipate)
Toxicol. Appl. Pharmacol., 31(2):283-9 (1975)
Jorque, M.A.
E (In a Study of) PCB's, Phthalates, and Other Organic Compounds
in the Ground Water. (Di-(2-ethylhexyl) Adipate)
Dissertation for Ph.D. University of Oklahoma (1973)
Diss. Abstr., 34(9):119 (Mar. 1974)
Kato, K.; Nakaoka, T.; Wada, Y.
Testing Method for Phthalates in Tableware and Toys.
(Di-n-octyl Adipate)
Kanagawa-Ken Eisei Kenkyusho Nempo, (22):123-5 (1973) (Jpn)
Kawamura, H.
E Microbiological Deterioration of Plasticized Polyvinyl
Chloride. (Di-n-octyl Adipate)
Plast. Ind. News, 20(ll):161-3 (1974)
OTS-1IC REPORT FILE
15
-------
Kawawata, S.; Takahata, N.
E Less Air Polluting Flame Retardant Vinyls for Cable Covering.
(Di-(2-ethylhexyl) Adipate)
Jpn. Plast. Age, (Sept-Oct):43-7 (1975)
Khamaev, V.K.; Kasyanov, V.A.; Kukovitskii, M.M.; et al.
Oxidative Thermal Stability of Adipic Acid Piasters and
Low-Molecular-Weight Naphthenic Alcohols.
Nefterpererab. Neftekhim. (Moscow), (8):20-2 (1977) (Rus)
Chem. Abstr., Abstr. No. 25260
Klausmeier, R.E.
E Results of the Second Interlaboratory Experiment on
Biodeterioration of Plastics.(Diisooctyl Adipate)
Int. Biodeterior. Bull., 8(l):3-7 (1972)
Koga, M.; Shinohara, R.; Kido, A.; et al.
E Identification and Analysis of Organic Substances in the
Environment. Analyses of Trace Organics in Water and Sediment.
(Di-(2-ethylhexyl) Adipate)
Koenshu-Iyo Masu Kenkyukai., 4:153-9 (1979) (Jpn)
Kopfler, F.C.; Melton, R.G.
H Human Exposure to Water Pollutants. (Di-(2-ethylhexyl) Adipate)
Symposium: 165th Meeting of the National American Chemical
Society. Environmental Chemistry Division, Philadelphia, PA,
Apr. 1975.
Advances in Environmental Science and Technology. Vol 8. Fate of
Pollutants in the Air and Water Environments. Part 2. Chemical
and Biological Fate of Pollutants in the Environment. Edited by
Suffet, I.H., New York: John Wiley and Sons, pp. 419-33,
(Pub 1979)
Kowa Company, Ltd.
H Antiinflammatory Analgesic Ointment. (Diisopropyl Adipate)
Japan, Patent No. 7806785
Jun. 23, 1978
Kowa Company, Ltd.
Nagai, H.; Muramatsu, T.; Inagi, T.
H Antiinflammatory and Analgesic Ointment Containing
Indomethacin.(Diisopropyl Adipate)
Japan, Patent No. 2429018
Jun. 22, 1978
Krylova, S.V.; Kulikova, A.E.; Ovchinnikov, Yu.V.
Effect of the Nature of Stabilizers on the Degradation of
Plasticizers during Gamma-Irradiation. (Di-n-octyl Adipate)
Plast. Massy, 15(12):22-5 (1973) (Rus)
16
-------
Krylova, S.V.; Kulikova, A.E.; Ovchinnikov, Yu.V.; et al.
Effect of Gamma-Irradiation on the Stability of Poly(Vinyl
Chloride) Plasticizers.(Di-(2-ethylhexyl) Adipate)
Plast. Massy (l):l6-8 (1973) (Rus)
Krylova, S.V.; Kulikova, A.E.; Ovchinnikov, Yu.V.; et al.
Breakdown of Plasticizers under Gamma-Radiation. (Di-n-octyl
Adipate)
Plast. Massy., (5):23-4 (1976) (Rus)
Labbauf, A.
H Chemical Hazards and Their Environmental and Health Impacts in
the Hot Melt Adhesives Industry.
Symposium: Tappi Course Notes, Cavalcade of Hot Melts, Their
Future, Their Problems. Hilton Head Island, SC, Apr. 18-21,
1977. pp. 76-85
Mallette, F.S.; Von Haam, E.
H Studies on the Toxicity and Skin Effects of Compounds Used in
the Rubber and Plastics Industries. II. Plasticizers.
Arch. Ind. Hyg. Occup. Med., 6:231-6 (Sept 1952)
Maxwell, T.; Milne, G.W.A.; Fales, H.M.; et al.
H Plasticizers in Blood - Real or Artifactual? (Di-(2-ethylhexyl)
Adipate)
Environ. Health Perspect., 3:139-40 (Jan. 1973)
McLennan, H.
H The Nature of the Receptors for Various Excitatory Amino-acids
in the Mammalian Cell Nervous System.
Symposium: Advances in Biochemical Psychopharmacology, Vol.
27. Glutamate As a Neurotransmitter. Porto Cervo, Sardina, May
1980. Edited by Di Chiara, G.; Gessa, G.L., New York: Raven
Press, pp. 253-62 (Pub. 1981)
Mironets, N.V.
H Comparative Sanitary-Toxicologic Characteristics of
Vinylmethyladipate and Divinyladipate Plasticizers and
Standardization of Their Content in Water.
Gig. Sanit., 35(10):88-9 (Oct. 1970) (Rus)
Moody, D.E.; Reddy, J.K.
H Hepatic Peroxisome (Microbody) Proliferation in Rats Fed
Plasticizers and Related Compounds. (Di-(2-ethylhexyl) Adipate)
Toxic. Appl. Pharmacol., 45(2):497-504 (Aug. 1978)
Nieto-Sampedro, M.; Shelton, D.; Cotman, C.W.
H Specific Binding of Kainic-acid to Purified Subcellular
Fractions from Rat Brain.
Neurochem. Res., 5(6):591-604 (1980)
17
-------
Nippon Nodaron Company, Ltd.
Noda, J.
H Nontoxic Poly(Vinyl Chloride) Hollow Balls. (Di-n-octyl Adipate)
Japan, Patent No. 7431779
Jul. 21, 1972
Nissenson, A.R.
H Plasticizer Effect on the Heart.
Ann. Intern. Med., 87(2):245 (Aug. 1977)
Obukova, M.F.; Baklanova, L.H.; Gnezdilova, N.D.
H Colorimetric Determination of Complicated Esters of Adipic-Acid
and Sebacic Acid in the Air Control of Industrial Premises.
Gig. Sanit., 36(11):80-2 (1971) (Rus)
Ogino, Y.; Saito, N.; Nagao, M.
E Analyses of Environmental Chemical Substances. 9. Systematic
Determination of bis(2-Ethylhexyl) Adipate, Diispdecyl Adipa'te
and bis(Butylglycol) AdipateJ(Di-(2-ethylhexyl) Adipate,
Diisodecyl Adipate)
Okayama-Ken Kankyo Hoken Senta Nempo, 3:167-72 (1979) (Jpn)
Ogner, G.
E Oxidation of Nonhydrolyzable Humic Residue and Its Relation to
Lignin.(Dimethyl Adipate)
Soil Sci., 116(2):93-9 (1973)
Ogner, G.
E Permanganate Oxidation of Ethanol Extract of Raw Humus.
(Dimethyl Adipate)
Acta Chem. Scand., 27(7):2586-90 (1973)
Ogner, G.
E Permanganate Oxidation of Methylated and Unmethylated Fulvic
Acid, Humic Acid, and Humin Isolated from Raw Humus'! (Dimethyl
Adipate)
Acta Chem. Scand., 27(5):1601-12 (1973)
Ogner, G.
E Permanganate Oxidation of Organic Matter from Forest Soil After
Fertilization with Urea!(Dimethyl Adipate)
Medd. Nov. Skogforsoeksv., 30(7):461-70 (1973)
Ogner, G.
E Permanganate Oxidation of the Hexane and Ether Extracts of Raw
Humus.(Dimethyl Adipate)
Soil Sci., 120(l):25-9 (1975)
Ogner, G.; Groenneberg, T.
E Permanganate Oxidation of Methylated Fulvic and Humic Acids in
Chloroform. (Di-n-octyl Adipate)
Geoderma., 19(3):237-45 (1977)
18
-------
Osman, J.L.; Klausmeier, R.E.
E Candida lipolytica, a Nonpathogenic Test Organism for
Deterioration of Plastics.(Diisodecyl Adipate)
Develop. Ind. Microbiol., 12:197-203 (1971)
Osman, J.L.; Klausmeier, R.E.; Jamison, E.I.
E Rate-limiting Factors in Biodeterioration of Plastics.
(Diisooctyl Adipate)
Proceedings: 2nd International Biodeterioration Symposium, 1971
Biodeterior. Mater.,:66-75 (1972)
Petersen, J.E.
H In Vivo Studies on the Metabolism of Hexanedioic Acid.
Clin. Chim. Acta (Netherlands), 58(1):43-50 (1975)
Ramsey, J.D.; Lee, T.D.; Osselton, M.D.; et al.
H Gas-Liquid Chromatographic Retention Indexes of 296 Nondrug
Substances on SE-30 or OV-1 Likely to Be Encountered .in
Toxicological Analyses"(Di-(2-ethylhexyl) Adipate),
n-Octyl-n-decyl Adipate, Di-n-octyl Adipate, Dinonyl Adipate,
Diisodecyl Adipate)
J. Chromatogr., 184(2):185-206 (1980)
Rohleder, K.; Bruchhausen, B.V.
H Direct Detection of the Transfer of Plasticizers from Plastics
into Fat and Fat-containing Foods. (Dimethyl Adipate)
Dtsch. Lebensm. Rundsch., 68(6):180-4 (1972) (Ger)
Rubin, R.J.
H Biomedical Implications of the Migration of Phthalate Ester
Plasticizers from PVC Plastic"(Di-(2-ethylhexyl) Adipate)
Symposium: Technical Conference, Society of Plastic
Engineering, Palisades Section. Mar. 20-22, 1973. pp. 81-3
Rubin, R.J.; Jaeger, R.J.
H Some Pharmacologic and Toxicologic Effects of Di-2-ethylhexyl
Phthalate (DEHP) and Other Plasticizers. (Di-(2-ethylhexyl)
Adipate)
Environ. Health Perspect., (3):53-9 (1973)
Saeger, V.W.; Kaley, R.G. 2nd; Hicks, 0.; et al.
E Activated Sludge Degradation of Adipic Acid Esters.
(Di-(2-ethylhexyl) Adipate)
Appl. Environ. Microbiol., 31(5):746-9 (1976)
Saito, K.; Itagaki, A.; Mochida, Y.; et al.
H Study of the Toxicity of Plastic Products to Cultured Cells.
(Di-(2-ethylhexyl) Adipate.)
Shimane-Ken Eisei Kogai Kenkyusho Ho, 19:48-52 (1977) (Jpn)
19
-------
Schnitzer, M.
E Alkaline Cupric-oxide Oxidation of a Methylated Fulvic Acid.
(Di-n-octyl Adipate)
Soil Biol. Biochem., 6(l):l-6 (1974)
Sears, K.
H Plasticizer Degradation Studies. Preliminary Report on Latent
Degradation.u>i-(2-ethylhexyl) Adipate, Diisodecyl Adipate.)
Am. Chem. Soc., Div. Paint, Plastics, Printing Ink Chem.,
Preprints, 18(l):256-75 (1958)
Sheldon, L.S.; Kites, R.A.
E Organic Compounds in the Delaware River. (Di-(2-ethylhexyl)
Adipate)
Environ. Sci. Technol., 12(10):1188-94 (1976)
Sheldon, L.S.; Kites, R.A.
E Sources and Movement of Organic Chemicals in the Delaware
River.(Di-(2-ethylhexyl) Adipate)
Environ. Sci. Technol., 13(5):574-9 (May 1979)
Shih, J.C.K.; Rozo, M.L.; Wright, L.D.; et al.
E Characterization of the Growth of Pseudomonas putida LP on
Lipoate and its Analogues; Transport, Oxidation, Sulphur
Source, and Enzyme Induction.
J. Gen. Microbiol., 86(2):217-27 (1975)
Shiono Koryo Kaisha, Ltd.
Kunishige, T.; Tanaka, Y.; Yoshioka, A.
H Pharmaceuticals for External Use. (Di-2-butoxyethyl Adipate)
Japan, Patent No. 8017310
Feb. 6, 1980
Simmon, V.F.; Kauhanen, K.; Tardiff, R.G.
H Mutagenic Activity of Chemicals Identified in Drinking Water.
(Di-(2-ethylhexyl) Adipate)
Dev. Toxicol. Environ. Sci., 2:249-58 (1977)
Simoneit, B.R.; Flory, D.A.; Reynolds, M.A.
E Organic Contamination Monitoring and Control in the Lunar
Receiving Laboratory.(Di-(2-ethylhexyl) Adipate)
Amer. Soc. Test. Mater. Spec. Tech. Publ., 539:16-34 (1973)
Singh, A.R.; Lawrence, W.H.; Autian, J.
H Embryonic-Fetal Toxicity and Teratogenic Effects of Adipic Acid
Esters in Rats. (Dimethyl Adipate, Di-(2-ethythexyl) Adipate)
J. Pharm. Sci., 62(10):1596-600 (1973)
Singh, A.R.; Lawrence, W.H.; Autian, J.
H Dominant Lethal Mutations and Anti-Fertility Effects of
Di-2-ethylhexyl Adipate and Diethyl Adipate in Male Mice.
(Di-(2-ethylhexyl) Adipate)
Toxicol. Appl. Pharmacol., 32(3):566-76 (Jun. 1975)
20
-------
Spiteller, M.; Spiteller, G.
Separation and Characterization of Acidic Urine Constituents.
(Dimethyl Adipate)
J. Chromatogr., 164(3):253-317 (1979) (Ger)
Spitzer, J.G.; Osipow, L.I.; Small, M.; et al.
H Aerosol Antiperspirant Compositions with Good Adherence to the
Skin.(Diisopropyl Adipate)
United States, Patent No. 4174386
Mar. 3, 1975
Thomae, K.G.m.b.H.; Naumann, C.; Wellenstein, K.A.
Deodorant Sprays Containing a Suspended Powder. (Diisopropyl
Adipate)
Germany, Patent No. 2503963
Jan. 31, 1975
Truhaut, R.; Coquet, B.; Fouillet, X.; et al.
H Two-Year Oral Toxicity and Multigeneration Studies in Rats on
Two Chemically Modified Maize Starches.
Food and Cosmet. Toxicol., 17(1):11-7 (1979)
United States. Department of Defense. Department of the Army
Blaisdell, C.T.
H Toxicity of Certain Engine Oils, Hydraulic Fluids, and Base Oils
for the Compounding of Both Hydraulic Fluids and Engine Oils.
(Di-(2-ethylhexyl) Adipate)
Medical Laboratories Research Report No. 256 Chemical Corps,
Army Chemical Center, MD, pp. 24 (Mar. 1954)
United States. Department of Defense. Department of the Army
Carson, T.R.; Edward, J.D.; Feinsilver, L.
H Responses of Animals Inhaling the Decomposition Products of Six
Lubricating Oils. (Di-(2-ethylhexyl Adipate)
Army Chemical Research and Development Labs, MD, Toxicology
Division, Proj. 4C61-14-002.
TR-CRDLR 3039, pp. 20 (Feb. 1961)
United States. Department of Energy
Buchan, R.M.; Majestic, J.R.; Billau, R.
H Toxicological Evaluation of Liquids Proposed for Use in Direct
Contact Liquid-Liquid Heat Exchangers for Solar Heated and
Cooled Buildings.
U.S. NTIS, COO/2867-1, 264 pp. (Sept. 1976)
United States. Department of Health, Education and Welfare.
Public Health Service. National Institutes of Health
Napier, E.A. Jr.
H Accumulation, Toxicity, and Metabolism of Common Plasticizers in
Humans.(Di-(2-ethylhexyl) Adipate)
U.S. NTIS, PB-224, 454(9):43 (Oct. 1973)
21
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United States. Department of Health, Education and Welfare.
Public Health Service. National Institutes of Health. National
Cancer Institute. National Heart and Lung Institute
Napier, E.A. Jr.
Accumulation, Toxicity, and Metabolism of Common Plasticizers in
Humans.(Di-(2-ethylhexyl) Adipate)
U.S. NTIS, PB-243 988/3SL, 19 pp. (May 1975)
United States. Department of Health, Education and Welfare.
Public Health Service. National Institutes of Health. National
Cancer Institute; National Heart and Lung Institute
Napier, E.A. Jr.
Accumulation, Toxicity, and Metabolism of Common Plasticizers in
Humans.(Di-(2-ethylhexyl) Adipate)
U.S. NTIS, PB-260 406/4SL, 6 pp. (Sep. 1976)
United States. Environmental Protection Agency
Keith, L.H.; Garrison, A.W.; Allen, F.R.; et al.
E Identification of Organic Compounds in Drinking Water from
Thirteen U. S. Cities.(Di-(2-ethylhexyl) Adipate)
Symposium: 1st Meeting of the Chemical Congress of the North
American Continent, 1975.
Identification and Analysis of Organic Pollutants in Water.
Edited by Keith, L.N. pp. 329-73 (1976)
United States. Environmental Protection Agency
Thruston, A.R. Jr.
High Pressure Liquid Chromatography Techniques for the Isolation
and Identification of Organics in Drinking Water Extracts.
(Di-(2-ethylhexyl) Adipate)
J. Chromatogr. Sci., 16(6):254-9 (1978)
United States. National Aeronautics and Space Administration
Wexler, T.
H The Toxicity of Plasticizers Used in Processing Plastics.
Mater. Plast., 7(9):478-9 (1969-70)
United States. National Aeronautics and Space Administration
Gross, F.C.; Colony, J.A.
E Etiological Study of Phthalate Self-contamination of Spacecraft
and Contamination from Their Earthly Environs.
(Di-(2-ethylhexyl) Adipate)
NASA Tech. Note D-6903, pp. 16 (1972)
United States. National Science Foundation
Stanford Research Institute.
Brown, S.L.; Chan, F.Y.; Jones, J.L.; et al.
H Research Program on Hazard Priority Ranking of Manufactured
Chemicals. Chemicals 41-60.(Di-(2-ethylhexyl) Adipate)
U.S. NTIS, PB-263-163, PB-263 164, 191 pp. (Apr. 1975)
22
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Vandervort, R.; Brooks, S.M.
H Polyvinyl-chloride Film Thermal Decomposition Products in
Occupational Illness. I. Environmental Exposure and
Toxicology.(Di-(2-ethylhexyl) Adipate)
J. Occup. Med., 19(3):188-91 (Mar. 1977)
Vick, R.D.; Junk, G.A.; Avery, M.J.; et al.
E Organic Emissions from Combustion of Combination Coal Refuse to
Produce Electricity.(Di-(2-ethylhexyl) Adipate)
Chemosphere, 7(11): 893-902 (1978)
Watanabe, R.; Sato, Y.
H Changes of Meat Fats by Various Processings. V. Volatile
Acidic Compounds in Heat-degradated Pork Fat. (Dimethyl Adipate)
Agr. Biol. Chem., 33(10):1411-8 (1969)
Weiss, A.J.; Francis, A.J.; Colombo, P.
E Characterization of Trench Water at the Maxey Flats Low-Level
Radioactive Waste Disposal Site.(Di-(2-ethylhexyl) Adipate)
Symposium: Management of Low Level Radioactive Waste, 2: 747-61
(1979)
Weschler, C.J.
H Characterization of Selected Organics in Size-fractionated
Indoor Aerosols.(Di-(2-ethylhexyl) Adipate)
Environ. Sci. Technol., 14(4):428-31 (1980)
Wiegand, V.W.
H Protein Binding of Several Drugs in Serum and Plasma of Healthy
Subjects.
Clin. Pharmacol. Ther., 27(3):297-300 (Mar. 1980)
Wildbrett, C.
H Diffusion of Phthalic Acid Esters from PVC Milk Tubing.
Environ. Health Perspect., 3:29-35 (1973)
Zalewski, W.
H Toxicity of Stabilizers and Plasticizers Contained in Vinyl
Chloride Used in Medicine.
Polim. Med., 7(Suppl.):35-43 (1977) (Pol)
23
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APPENDICES
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Appendix I
Abstract Collections Manually Searched
Source Period of Coverage
Chemical Abstracts* (1930-1976)
Biological Abstracts* (1930-1970)
Excerpta Medica*
Physiology, Biochemistry, Pharmacology, . (1965-1974)
Toxicology
Cancer (1953-1974)
Public Health, Social Medicine, Hygiene (1955-1974)
Clinical Biochemistry (1969-1974)
Pharmacology and Toxicology (1969-1974)
Occupational Health (1972-1975)
Current Contents
Life Sciences (Oct. 1979-Mar. 1980)
(Apr. 1981-May 1981)
Physical Sciences (Oct. 1979-Mar. 1980)
(Apr. 1981-May 1981)
Agriculture (Oct. 1979-Mar. 1980)
(Apr. 1981-May 1981)
Industrial Hygiene Digest (1943-1979)
Index Medicus* (1930-1976)
Toxicology Research Projects Directory (Oct. 1979-Mar. 1980)
*Recent issues searched on-line.
-------
Appendix II •
On-Line Databases Searched
National Library of Medicine (MEDLARS)
File -^ Coverage Period of File
+ indicates that the database is continually updated.
Chemline N/A
Toxline 1974+
Toxback 1965-1973
Cancerlit Jan. 1963+
Cancerproj 1976-1978
Medline Jan. 1977+
Back 66 Jan. 1966-Dec. 1968
Back 69 Jan. 1969-Dec. 1971
Back 72 Jan. 1972-Dec. 1974
Back 75 Jan. 1975-Dec. 1976
Back 77 Jan. 1977-Dec. 1978
SDILINE Present Month's Update
Toxicology Data Bank N/A
RTECS 1978 Edition
Search Strategy
(TW) adipic and acid and ester:
(TW) adipate
(TW) hexanedioic and acid ester:
(TW) adipol
(TW) bisoflex
(TW) doa
(TW) effomoll
(TW) . ergoplast
(TW) flexol
(TW) kodaflex
(TW) monaplex
-------
Search Strategy
(TW) plastomoll
(TW) sicol
(TW) truflex
(TW) vestinol
(TW) wickenol
(TW) witamol
(TW) adimoll
(TW) staflex
(TW) isodecyladipate
(TW) vinicizer
(TW) DIOA
(TW) hercoflex
(TW) monoplex
(TW) hexanedioate
(TW) ceraphyl
(TW) staudanol
(RN) 103-23-1*
(RN) 123-79-5*
(RN) 141-18-4*
(RN) 27178-16-1*
(RN) 1330-86-5*
(RN) 22707-35-3*
(RN) 141-17-3*
(RN) 110-29-2*
(RN) 627-93-0*
(RN) 151-32-6*
(RN) 68515-75-3*
(RN) 108-63-4*
(RN) 6938-94-9*
(RN) 16958-92-2*
All search statements were combined with the logical operator "or" before
printout.
*CAS registry numbers used in appropriate files.
-------
Appendix II
On-Line Databases Searched (cont'd)
Lockheed Information Systems (DIALOG)
File
Coverage Period of File
+ indicates that the database is continually updated
Agricola
Air Pollution Technical Information Center
Aquatic Sciences and Fisheries Abstracts
Biosis Previews
Chemical Abstracts Search
Commonwealth Agriculture Bureaux Abstracts
Chemical Industry Notes
Chemname
Claims/Chem
Comprehensive Dissertation Abstracts
Conference Papers Index
Current Research Information System
EIS Industrial Plants
Enviroline
Environmental Periodicals Bibliography
Excerpta Medica
Food Science & Technology Abstracts
GPO Monthly Catalog
National Technical Information Service
Oceanic Abstracts
Pollution Abstracts
PTS Funk and Scott Indexes
PTS Federal Index
PTS Promt
PTS Annual Time Series
PTS US Statistical Abstracts
Rubber & Plastics Research Association Abstracts
SciSearch
Smithsonian Science Information Exchange
Current Research Information System
Compendex
Ins pec
Metadex
Pira
Claims/U.S. Patent
Claims/U.S. Patent
Claims/Class
Aug. 1971+
1976-Sep. 1978
Jan. 1975+
1969+
1970+
Jan. 1973+
1974+
N/A
1950-1970
1861 +
1973+
Jul. 1974+
N/A
1971+
1973+
Jun. 1974+
1969+
Jul. 1973+
1964+
1964+
1970+
1972+
Oct. 1976+
1972+
Jul. 1971+
Jul. 1971+
1972+
Jan. 1974+
Most Recent 2 Yrs
Jul. 1974+
1970+
1969+
1966+
1975+
Abstracts Weekly
1971+
Oct. 1975+
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Appendix II
On-Line Databases Searched (cont*d)
Lockheed Information Systems (DIALOG)
Search Strategy
adipic(w)acid(f) esters?
hexanedioic(w)acid(f)ester?
adipate
adipol
bisoflex
DOA
effomoll
ergoplast
flexol
kodaflex
monaflex
plastomoll
sicol
truflex
vestinol
wickenol
witamol
adimoll
adipol
staflex
isodecyladipate
vinicizer
DIOA
hercoflex
monoplex
hexanedioate
ceraphyl
staudanol
103-23-1*
123-79-5*
141-18-4*
27178-16-1*
1330-86-5*
22707-35-3*
141-17-3*
110-29-2*
627-93-0*
151-32-6*
68515-75-3*
108-63-4*
6938-94-9*
16958-92-2*
*CAS Registry numbers used in appropriate files.
-------
Database
Appendix II
On-Line Databases Searched (cont'd)
Systems Development Corporation (ORBIT)
Coverage Period of File
+ indicates that the database is continually updated.
Apilit
Apipat
Chemdex
Crecord
Fedreg
Libcon
Paperchem
P/E News
Safety Science
Titus
World Patent Index
Search Strategy
adipic and acid and ester:
adipate
hexanedioic and acid and ester:
adipol
bisoflex
doa
effomoll
ergoplast
flexol
kodaflex
mona £1ex
plastomoll
sicol
truflex
vestimol
1974+
1964+
1972+
1976+
Mar. 1977+
1968+
1968+
1975
Jun. 1975+
1970+
1963+
-------
Search Strategy
wickenol
witamol
adimoll
adipol
staflex
isodecyladipate
vinicizer
DIOA
hercoflex
monoplex
hexanedioate
ceraphyl
staudanol
103-23-1*
123-79-5*
141-18-4*
27178-16-1*
1330-86-5*
22707-35-3*
141-17-3*
110-29-2*
627-93-0*
151-32-6*
68515-75-3*
108-63-4*
6938-94-9*
16958-92-2*
*CAS Registry numbers used in appropriate files
All search statements were combined with the logical operator "or" before
printout.
-------
Appendix II
On-Line Databases Searched (cont'd)
Department of Energy (RECON)
File Coverage Period of File
+ indicates that the database is continually updated.
Water Resources Abstracts 1968+
Environmental Mutagen Information Center 1969+
Environmental Teratogen Information Center 1975+
Search Strategy
IT=adipic acid, bis(2-ethylhexyl)ester
IT=hexanedioic acid, bis(2-ethylhexyl)ester
IT=adipic acid, dioctyl ester
IT=hexanedioic acid, dioctyl ester
IT=adipic acid, bis(2-butoxyethyl)ester
IT=hexanedioic acid, bis(2-butoxyethyl)ester
IT=adipic acid, diisodecyl ester
IT=hexanedioic acid, diisodecyl ester
IT=adipic acid, diisooctyl ester
IT=hexanedioic acid, diisooctyl ester
IT=adipic acid, decyl hexyl ester
IT=hexanedioic acid, decyl hexyl ester
IT=adipic acid, bis(2-(2-butoxyethoxy)ethyl)ester
IT=hexanedioic acid, bis(2-(2-butoxyethoxy)ethyl)ester
IT=adipic acid, bis(diethylene glycolmonobutyl ether)ester
IT=bis(2-(2-butoxyethoxy)ethyl)adipate ester
IT=adipic acid, decyl octyl ester
IT=hexanedioic acid, decyl octyl ester
IT=adipic acid, dimethyl ester
IT=hexanedioic acid, dimethyl ester
IT=adipic acid, dinonyl ester
IT=hexanedioic acid, dinonyl ester
IT=adipic acid, bis(l-methylheptyl)ester
IT=hexanedioic acid, b(l-methylheptyl)ester
IT=adipic acid, diisopropyl ester
IT=hexanedioic acid, diisopropyl ester
IT=adipic acid, ditridecyl ester
IT=hexanedioic acid, ditridecyl ester
-------
Appendix II
On-Line Databases Searched (cont'd)
Department of Energy (RECON)
Search Strategy
RN-103-23-1
RN=123-79-5
RN=141-18-4
RN=27178-16-1
RN=1330-86-5
RN=22707-35-3
RN=141-17-3
BN=110-29-2
RN-627-93-0
RN-151-32-6
RN-68515-75-3
RN=108-63-4
RN=6938-94-9
RN=16958-92-2
Chemical Information System (Environmental Protection Agency CIS)
Structure and Nomenclature Search System (SANSS)*
Clinical Toxicology of Commercial Products (CTCT)
(RN) 103-23-1
(RN) 123-79-5
(RN) 141-18-4
(RN) 27178-16-1
(RN) 1330-86-5
(RN) 22707-35-3
(RN) 141-17-3
(RN) 110-29-2
(RN) 627-93-0
(RN) 151-32-6
(RN) 68515-75-3
(RN) 108-63-4
(RN) 6938-94-9
(RN) 16958-92-2
* Searched to obtain synonyms only.
-------
Appendix II
On-Line Databases Searched (cont'd)
National Institute for Occupational Safety and Health
NIOSHTIC 1973+
+ indicates that the database is continually updated.
Search Strategy
103-23-1
123-79-5
141-18-4
27178-16-1
1330-86-5
22707-35-3
141-17-3
110-29-2
627-93-0
151-32-6
68515-75-3
108-63-4
6938-94-9
16958-92-2
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