s>EPA
United Stun
Environmental Protection
Agency
Office of Pesticide* and
Toxic Substances
Washington. DC 20460
EPA 560/7-81-012
July 1981
Tome Substances
Environmental and
Health Aspects of
Cyclohexylamine
A Comprehensive
Bibliography of Published
Literature
1930 - 1981
-------
v>EPA
United States .
Environmental Protection
Agency '.
Office of Pesticides and
Toxic Substances
Washington, DC 20460
EPA 68-01-6021 Rept A
July 1381
Toxic Substances
Environmental and
Health Aspects of
Cyclohexylamine
A Comprehensive
Bibliography of Published
Literature
1930- 1981
-------
50277-101
REPORT DOCUMENTATION ,.i._ REPORT NO.
PAGE I EPA 560/7-81-012
4. . .no
ti* Environmental and Health Aspects of
Cyclohexylamine, A Conprehensive Biobliography of Published
Literature 1930-1981
7. Author(s)
3. Recipient's Accession No.
s. Report Date prepared
June 1981
8. Performing Organization Rept. No.
9. Performing Organization Nam* end Address
Tracer Jitco, Inc.
1776 East Jefferson Street
Rockville, Maryland 20852
10. Project/Task/Worfc Unit No.
Technical Directive 6
11. Contract(C) or Gr»nt(G> No.
(C) 68-01-5836
(G)
12- Sponsoring Organization Name and Address
Environmental Protection Agency, Office of Pesticides and
Toxic Substances, Management Support Division, 401 M Street SW,
Washington, D.C. 20460
13. Type of Report i Period Covered
Final Report
1930-1981
14.
15. Supplementary Notes
16. Abstract (Limit: 200 words)
This document is a bibliography of published citations on health and
environmental aspects of Cyclohexylamine (Chemical Abstracts Service
Registry Number 108-91-8) and its simple nitrite, sulfate, and hydro-
chloride salts (Chemical Abstracts Service Registry Numbers 24407-06-5;
27817-50-1 and 4998-76-9 respectively) for the period 1930 to May 1981.
The citations have been selected from a thorough literature search, and
broadly classified as having primarily environmental or biological
emphasis. The sources used in the search are identified, and for the
portion performed on line, the search strategies are also included.
17. Document Analysis *. Descriptors
Bibliographies; Literature Surveys; Environments; Public Health; Pollution;
Toxicology.
b. Identifiers/Open-Ended Terms
Literature Search; Literature Review; Health Effects; Environmental
Effects; Cyclohexylamine; Cyclohexylamine hydrochloride; Cyclohexylamine
nitrite; Cyclohexylamine sulfate; 108-91-8; 24407-06-5; 27817-50-1;
4998-76-9
c. COSATI Field/Group
18. Availability Statement
Release unlimited
19. Security Class (This Report)
Unclassified
20. Security Class (This Page)
Unr1
21. No. of Pages
22. Price
(See ANSI-Z39.18)
See /nttruc*»on$ on Reverse
OPTIONAL FORM 272 (*-77)
(Formerly NTIS-35)
Department of Commerce
-------
EPA Report No. 560/7^81-12
July 1981
ENVIRONMENTAL AND HEALTH
ASPECTS OF CYCLOHEXYLAMINE
A Comprehensive Bibliography
of Published Literature
1930 - 1981
by
Management Support Division
Information Support Service Branch
Office of Toxic Substances
Washington, D.C. 20460
68-06-5836
Project Officers
Michael Weaver, Delores Evans
Management Support Division
Office of Toxic Substances
Washington, D.C. 20460
OFFICE OF TOXIC SUBSTANCES
U.S. ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, D.C. 20026
-------
Preface
This bibliography was created from a literature search performed under
the auspices of the Management Support Division, Information Support Services
Branch for the Assessment Division, Chemical Review and Evaluation Branch;
both of the Office of Toxic Substances. The search was intended to provide
partial support for the preparation of a Preliminary Risk Assessment on
cyclohexylamine (108-91-8) and selected simple salts of cyclohexylamine. This
assessment reviews and evaluates the available significant economic and
adverse effects data from both published and unpublished sources on a
substance selected as being potentially hazardous to human health or the
environment.
The subject coverage of the assessment is broader than this bibliography
which includes only published environmental and biological information. The
bibliography does not include all information available to the review branch.
Although it is not an authoritative source list for Preliminary Risk
Assessments, it does represent a comprehensive and systematic search of the
literature and subsequent selection of citations that pertain to health and
the environment. The limits of the search are fully described in this
document and its appendices.
-------
Introduction
1. The Search
This bibliography is a compilation of citations retrieved during a
thorough review of the national and international literature on
cyclohexylamine (Chemical Abstracts Service Registry Number 108-91-8) and
selected simple salts of cyclohexylamine cited between 1930 and April 1980.
The supporting search was performed at the request of the Assessment
Division/Chemical Review and Evaluation Branch by the Management Support
Division/Information Support Services Branch, within the Office of Toxic
Substances.
1.1. Scope
To insure that the search was comprehensive, a variety of sources were
examined, including the following:
o On-line databases from major vendors of bibliographic information.
o On-line databases from various agencies of the United States
Government.
o Manually searched national and international indices and abstract
collections of scientific literature.
o Reference sections of major review articles, criteria documents,
monographs, and reports.
o Selected handbooks.
(A complete listing of sources consulted can be found in Appendices I
and II).
The emphasis of this bibliography is on the primary literature except
for the handbook information presented in Section II and a few secondary
sources selected because they contain unique or well-summarized information on
the chemical.
Subsequent to the main search, which was completed in April 1980, and
using the same strategy, update searches were performed during the period from
April 1980 to May 1981 on all the on-line databases initially searched. In
addition, the April 1981 and May 1981 issues of Current Contents (Life
Sciences, Agriculture, Biology, and Environmental Sciences series) were
screened to retrieve citations which may not have been entered into the
on-line files at the time of the final update searches.
11
-------
Because the overall requirement of the search request for this project
was broader than the health and environmental aspects of the chemical, a wider
range of databases was searched than might normally be expected for this
bibliography. However, only health and environmental aspects were selected
regardless of the data source examined. The total complement of databases
searched is listed in the appendices for the user's reference.
1.2. Strategy
The search requirement demanded high recall of information dealing with
cyclohexylamine and selected simple salts of cyclohexylamine; precision was a
secondary consideration. EPA decided to retrieve all citations that contained
the terms cyclohexylamine and selected simple salts of cyclohexylamine or
their synonyms in any searchable fields and to select relevant citations by a
manual screen. The Chemical Abstract Service registry number (CAS RN) and
systematic names and synonyms that could be identified from CHEMLINE (National
Library of Medicine); CHEMDEX (System Development Corporation); CHEMNAME,
CHEMSEARCH, and CHEMSIS (Lockheed Information System); SANSS (NIH/EPA Chemical
Information System); and RTECS (NIOSH Registry of Toxic Effects of Chemical
Substances) were used in the search on databases. For on-line searching, the
names were divided into significant fragments and entered according to the
conventions of the individual databases.
Chemical terms used in this search were as follows:
CAS RN: 108-91-8
Cyclohexylamine (8CI)
Cyc1ohexanamine (9CI)
Aminocyclohexane
Aminohexahydrobenzene
CHA (selectively searched)
Hexahydroaniline
Hexahydrobenzenamine
Cyclohexylamine hydrobromide (26227-54-3)
Cyclohexylamine hydrochloride (4998-76-9)
Cyclohexanamine hydrochloride
Cyclohexylammonium hydrochloride
Cyclohexylamine hydrofluoride (26593-77-1)
Cyclohexylamine nitrate (6941-45-3)
Cyclohexylamine nitrite (24407-06-5)
Cyclohexanamine nitrite
Cyclohexylamine phosphate (16545-55-4)
Cyclohexylamine phosphite (15830-14-5)
Cyclohexanamine phosphonate
Cyclohexylamine sulfate (27817-50-1)
Cyclohexanamine sulfate
Cyclohexylamine sulfate (19834-02-7)
Cyclohexanamine sulfate
No additional modifiers or keywords were used to limit information
retrieved in any database for this chemical because comprehensive retrieval
was desired. Complete search strategies are listed in Appendix II.
iii
-------
Use/application categories were not used as search terms because EPA
decided to select only terms that specifically mentioned the chemical or its
synonyms. Indexing policy, keyword entry, and abstracting techniques usually
assure retrieval of specific information on individual chemicals if they are
discussed significantly in general articles or reviews. The user can be
assured, therefore, that each citation listed in this bibliography contains
substantive information on the subject chemical.
Manual sources, indices, and abstract collections usually employ their
own unique indexing schemes for chemical information, so it is difficult to
describe a standard search strategy for these information tools. However, in
all cases, the most specific indexing terms available in the source were used
to identify citations on the subject chemical.
1.3. Selection of Citations
Citations were selected for inclusion in this bibliography based on
their relevance to the following topics:
o Toxicity Adverse and toxic effects on any biological systems,
structural and functional changes in organs and tissues of all
vertebrate and invertebrate species, test methods used for
determination of toxicity, and bioassay studies.
o Physiology Absorption, distribution, transport, metabolism, and
elimination in all species; techniques for measurement of tissue and
organ residues; interactions with endogenous substances.
o Epidemiology Exposure data, morbidity, and mortality rates for
general and occupational populations.
o Environmental Significance Environmental distribution in air,
soil, and water; sources of pollution; ecological effects on
microorganisms, insects, plants, and wildlife; biodegradation and
bioconcentration; analytical techniques for sampling and measurement
in the environment.
o Safety, Control, and Regulations Disposal hazards; Federal, local,
and international controls, recommendations, and regulations.
These are the broad specifications for inclusion in this bibliography.
Because any literature selection process involves subjectivity and judgement,
precise definitions are difficult. The general guiding requirement for
inclusion is that citations must pertain to the biological or environmental
aspects of the chemical.
The following information is not included in this bibliography:
news items; brief announcements and Federal Register notices; reports
of on-going research which have not yet been published or any other
unpublished information; draft reports; and private communications.
IV
-------
2. Organization of Bibliography
This bibliography is organized into three major sections.
2.1. Section Titles
Section I Handbook information
Section II Citations from the primary literature
Section III Appendices listing specific sources used and exact
search strategies employed
2.2. Citation Format
In Section II citations from on-line and manually searched abstract
collections are arranged alphabetically by author.
Personal names are entered with the last name first followed by the
first two initials. Second and third authors' names are separated from the
first author and each other by a semicolon. Up to three personal names are
used; if there are more than three authors, the remaining are listed as
"et al."
If an author has written more than one article, citations are arranged
in ascending chronological order. If authors and date are identical,
citations are arranged alphabetically by title of the article. Single author
entries are listed first, followed by two, then three author entries.
Patents are arranged alphabetically by assignee name.
All government publications are listed by the sponsoring government
agency. Government or corporate names are written in full form. No acronyms
are used. The country of origin is listed first, followed by the
organizational hierarchy of the sponsoring group listed in descending
hierarchical order. If the performing organization or individual author is
known, they are listed on separate lines below the government sponsor.
Example: NIOSH publication:
United States. Department of Health, Education and Welfare. Public
Health Service. Center for Disease Control. National Institute for
Occupational Safety and Health
Tracer Jitco, Inc.
Brown, R.A.; Smith S.S.
Corporate documents with no specific author are listed in alphabetical
order according to the first significant word of the organization name.
e.g., DuPont de Nemours, E.I. and Company
-------
2.3. Literature Cited
The following kinds of literature are cited in this bibliography:
journal articles, government reports, patents, organization and corporate
reports, books, manufacturer's literature, conference proceedings, and
dissertations.
In each case an attempt has been made to supply the user with enough
information so that the hard copy of the document may be easily obtained.
Journal titles are abbreviated according to the style in the Chemical
Abstracts Service Source Index (CASSI), The American Chemical Society,
Columbus, OH, 1980 and its corresponding guide, Bibliographic Guide for
Editors and Authors, The American Chemical Society, Washington, DC, 1974.
All foreign titles have been translated into English. Foreign language
articles are indicated by the appropriate three letter language abbreviation
in parentheses at the end of the source information.
2.4. Categorization of Citations
In order to make this bibliography a more useful tool for separate user
groups, most citations are marked with the category code E or H.
E = Environmental Aspects, i.e., the major content of the document
pertains to the chemical in the open environment: its distribution,
degradation, environmental chemistry and analysis; effect on
ecosystems; effect on flora and fauna, including laboratory research,
when emphasis is on environmental considerations rather than
prediction of human effects, environmental chemistry, and analysis.
H = Health Aspects, i.e., the major content of the document concerns
known health effects, predictive laboratory research, and animal
studies as relates to human health effects, human exposure, and
epidemiological studies.
A decision was made based on the abstract, and in some cases the entire
document, to categorize according to what appeared to be the major purpose of
the study. In a few cases neither category applies. Those citations were
left unclassified.
VI
-------
HANDBOOK
AND
DATABANK
INFORMATION
-------
3. Handbook and Databank Information
3.1. Summary Databanks for Health Effects Data (information found)
United States. Department of Health and Human
Services. Public Health Service. Center for Disease yes
Control. National Institute for Occupational
Safety and Health
Registry of Toxic Effects of Chemical Substances.
Cincinnati, OH: NIOSH, 1980
United States. Department of Health and Human
Services. Public Health Service. National
Institutes of Health. National Library of Medicine yes
Toxicology Data Bank.
Bethesda, MD 1980
-------
3.2. Handbooks Searched for Health Effects
Source
Browning, E.
Toxicity and Metabolism of Industrial Solvents.
New York: Elsevier Publishing Co., 1963
Location of Information
None
Browning, E.
Toxicity of Industrial Metals.
New York: Appleton-Century-Crofts, 1969
None
Dittmer, D.S., Editor
Handbook of Toxicology, V. - Fungicides.
Philadelphia: W. B. Saunders Company, 1959
None
Fishbein, L.
Potenial Industrial Carcinogens and Mutagens.
New York: Elsevier Scientific Publishing Co., 1979
None
Fishbein, L.; Flamm, W.G.; Falk, H.L.
Chemical Mutagens.
New York: Academic Press, 1970
pp. 247-9
Goodman, L.S.; Oilman, A., Editors
The Pharmacological Basis of Therapeutics.
New York: Macmillan Publishing Co., Inc., 1975
None
Patty, F.A., Editor
Industrial Hygiene and Toxicology.
New York: Interscience Publishers, 1963
pp. 2038-40,
2045,
2049-51,
2058-9
Plunkett, E.R.
Handbook of Industrial Toxicology.
New York: Chemical Publishing Co., Inc., 1976
pp. 124
Sax, N.I.
Dangerous Properties of Industrial Materials.
New York: Van Nostrand Reinhold Co., 1979
p. 530
Searle, C.E., Editor
Chemical Carcinogens.
Washington, DC: American Chemical Society, 1976
2
None
-------
3.2. Handbooks Searched for Health Effects (cont'd)
Source Location of Information
Shepard, T.H. p. 61
Catalog of Teratogenic Agents.
Baltimore, MD: The Johns Hopkins University
Press, 1976
Spector, W.S., Editor pp. 82-3
Handbook of Toxicology, V. I. - Acute Toxicities.
Philadelphia: W. B. Saunders Company, 1956
Spector, W.S., Editor None
Handbook of Toxicology, V. II. - Antibiotics.
Philadelphia: W.B. Saunders Company, 1957
Spector, W.S., Editor None
Handbook of Toxicology, V. III. - Insecticides.
Philadelphia: W.B. Saunders Company, 1959
Sunshine, I., Editor None
CRC Handbook Series in Analytical Toxicology.
Boca Raton, FL: CRC Press, Inc., 1979
United Nations. International Agency for Research on Vol. 22,
Cancer pp. 64-109
IARC Monographs on the Evaluation of the Carcinogenic
Risk of Chemicals to Humans.
Lyon, France: IARC
United States. Department of Health and Human None
Services. Public Health Service. Center for
Disease Control. National Institute for
Occupational Safety and Health
NIOSH Criteria Documents.
Cincinnati, OH: NIOSH
United States. Department of Health and Human None
Services. Public Health Service. National Institutes
of Health. National Cancer Institute
NCI Carcinogens Bioassay Reports.
Springfield, VA: National Technical Information
Service
-------
3.2. Handbooks Searched for Health Effects (cont'd)
Source Location of Information
United States. Department of Health and Human (Suppl. 2):118
Services. Public Health Service. National Institutes 1972-3:407
of Health. National Cancer Institute 1978:292
Survey of Compounds Which Have Been Tested for
Carcinogenic Activity.
Bethesda, MD: NCI, 1978
United States. Environmental Protection Agency None
EPA Publications Bibliography.
Washington, DC, EPA
-------
3.3. Handbooks Searched for Environmental Effects
Source
Applegate, V.C.; Howell, J.H.; Hall, A.E.; et al.
Toxicity of 4,346 Chemicals to Larval Lampreys' and
Fishes: Special Scientific Report.
Fisheries No. 207, Washington, DC, 1957
Location of Information
None
McKee, J.E.; Wolf, H.W., Editors
Water Quality Criteria, 2nd Edition.
California State Water Resources Control Board, 1963
None
Ryckman, D.W.; Prabhakara Rao, A.V.S.; Buzzel, J.C.
Behavior of Organic Chemicals in the Aquatic
Environment.
Washington, DC: Manufacturing Chemists' Association,
1966
None
United States. Environmental Protection Agency
Review of the Environmental Fate of Selected Chemicals.
Springfield, VA: National Technical Information
Service, 1977
None
United States. Environmental Protection Agency
Review of the Environmental Fate of 129 Priority
Pollutants.
Springfield, VA: National Technical Information
Service, 1977
None
Verschueren, K.
Handbook of Environmental Data on Organic Chemicals.
New York: Van Nostrand Reinhold Co., 1977
p. 210
-------
3.4. Handbooks Searched for Physical and Chemical Properties
Source
Aldrich Chemical Company, Inc.
Aldrich Catalog Handbook of Fine Chemicals. 1981-2.
Milwaukee, WI: Aldrich Chemical Co., 1980
Location of Information
p. 271
Bennet, H., Editor
Concise Chemical and Technical Dictionary.
New York: Chemical Publishing Co., Inc., 1974
p. 308
Dreisback, R.R.
Physical Properties of Chemical Compounds.
Washington, DC: American Chemical Society, 1959
None
Grasselli, J.G.; Ritchey, W.M., Editors
CRC Atlas of Spectral Data and Physical Constants
for Organic Compounds.
Boca Raton, FL: CRC Press, 1975
p. 105
Grayson, M., Editor
Kirk-Othmer Encyclopedia of Chemical Technology.
New York: Interscience Publishers, 1979
2:82,124,416-7
6:332,648
12:116
Hawley, G.G.
The Condensed Chemical Dictionary.
New York: Van Nostrand Reinhold Co., 1977
p. 248
Kortum, G.; Vogel, W.
Dissociation Constants of Organic Acids in Aqueous
Solution.
London: Butterworths, 1961
None
Leo, A.; Hansch, C.; Elkins, D.
Chemical Reviews.
Claremont, CA: Department of Chemistry, Pomona
College, 1971
None
Linke, W.F.
Solubilities of Inorganic and Metal-Organic Compounds.
New York: D. Van Nostrand Co., Vol. I. 1958, Vol. II. 1965
None
-------
3.4. Handbooks Searched for Physical and Chemical Properties (cont'd)
Source
Mark, H.F.; Gaylord, N.G.; Bikales, N.M., Editors
Encyclopedia of Polymer Science and Technology.
New York: Interscience Publishers, 1964
Location of Information
None
Perry, R.H.; Chilton, C.H., Editors
Chemical Engineers Handbook.
New York: McGraw-Hill Book Co., 1973
pp. 3-31
Pollock, J.R.; Stevens, R., Editors
Dictionary of Organic Compounds.
London: Eyre and Spottiswoode Publishers, Ltd., 1965
p. 790
Stephen, H.; Stephen, T.; Editors
Solubilities of Inorganic and Organic Compounds.
New York: The Macmillan Co., 1963
None
Weast, R.C., Editor
CRC Handbook of Chemistry and Physics.
Boca Raton, FL: CRC Press, 1979
p. C-260
Windholz, M., Editor
The Merck Index.
Rahway, NJ: Merck and Co., Inc.,
1976
p. 357
-------
CITATIONS
FROM THE
LITERATURE
-------
Abdul-Cader, Z.; Eaves, C.T.; Wood, P.J.; et al.
H Effects of Quaternary Ammonium Compounds on Brain
Sodium-Plus-Potassium Ion-Stimulated Adenosine Triphosphatase.
Biochem. Soc. Trans., l(l):126-9 (1973)
Aleksandrova, L.G.; Klisenko, M.A.
H Kinetics of the Accumulation and Elimination of Thiocarbamine
Pesticides from Warm-31ooded Animals.
Gig. Sanit., 43(6):101-3 (1978) (Rus)
Alexander, R.L.
H Phencyclidene and Chemical "Stroking".
J. Nat. Med. Assoc., 72(9):845-50 (1980)
Althoff, J.; Cardesa, A.; Pour, P.; et al.
H A Chronic Study of Artificial Sweeteners in Syrian Golden
Hamsters.
Cancer Lett., l(l):21-4 (1975)
Anderson, D.; Styles, J.A.
H An Evaluation of Six Short-Term Tests for Detecting Organic
Chemical Carcinogens. Appendix II. The Bacterial Mutation Test.
Br. J. Cancer, 37:924-30 (1978)
Anon.
H Animal Experiments with Cyclamate, Cyclohexylamine, and
Saccharin.
Bundesgesundheitsblatt, 16(25-6):379 (1973)
Anon.
H BIBRA Study Answers Questions on Cyclamate Toxicity.
Food Prod. Dev., 9(5):44 (1975)
Anon.
H Cyclamate Still to the Fore.
Food Cosraet. Toxicol., 10(2):237-43 (1972)
Anon.
H Genetic Damage by Chemicals.
Munch. Med. Wochenschr., 120(49):1622-3 (1978)
Anon.
H Investigation of Plastics Used for Utensils in Relation to Food
Regulations. XXXII. Special Methods for Analysis of Polyamide
Utensils.
Bundesgesundheitsblatt, 18(7):118-20 (1975)
Analyt. Abstr., 30(4):355 (Apr. 1976)
Anon.
H Toxicology; Abstracts and Comments. Flavourings, Solvents, and
Sweeteners.
Food Cosmet. Toxicol., 6:801 (1968)
11
-------
Asahina, M.
H Participation of Bacteria in the Metabolism of Sodium Cyclamate
in Guinea Pig.
Shokuhin Eiseigaku Zasshi, 13(2):133-6 (1972) (Jpn)
Asahina, M.; Nimura, T.; Yamaha, T.; et al.
H Formation of Cyclohexanone from Cyclamate by Microorganisms
Isolated from the Feces of Guinea Pig.
Agric. Biol. Chem., 36(5):711-8 (1972)
Asahina, M.; Yamaha, T.; Sarrazine, G.; et al.
H Conversion of Cyclamate to Cyclohexylamine in the Guinea Pig.
Chem. Pharm. Bull., 20(0:102-8 (1972)
Asahina, M.; Yamaha, T.; Watanabe, K.; et al.
H Excretion of Cyclohexylamine, a Metabolite of Cyclamate, in
Human Urine.
EMS Newsl., 3:29 (1970)
Bailey, D.E.; Morgareidge, K.; Cox, G.E.; et al.
H Chronic Toxicity, Teratology, and Mutagencity Studies with
Cyclohexylamine in Rats.
Toxicol. Appl. Pharmacol., 22:330-1 (1972)
Bailey, K.; Legault, D.
H Identification of Cyclohexylamine, Hencyclidine, and Simple
Analogues by Carbon-13 Nuclear Magnetic Resonance Spectroscopy.
Anal. Chim. Acta. (Netherlands), 113(2):3765-81 (1980)
Baldessarini, R.J.
H Compounds Antagonistic to Norepinephrine Retention by Rat Brain
Homogenates.
Biochem. Pharmacol., 20(8):1769-80 (1971)
Bari, B.B.; Baril, E.F.; Laszlo, J.; et al.
H Inhibition of Rat Liver DNA Polymerase by Nitrosoureas and
Isocyanates.
Cancer Res., 35(1):1-5 (1975)
Barilyak, I.R.; Paustovskaya, V.V.; Torbin, V.F.
H Characteristics of the Effect of Some Inhibitors of Atmospheric
Metal Corrosion (Amines of Polymethylene Series) on
Embryogenesis.
Arkh. Anat., Grstol. Embriol., 74(3):80-7 (1978) (Rus).
Becker, B.A.; Gibson, J.E.
H Teratogenicity of Cyclohexylamine in Mammals.
Toxicol. Appl. Pharmacol., 17:551-2 (1970)
12
-------
Behe, M.J.; Englander, S.W.
H Quantitative Assessment of the Noncovalent Inhibition of Sickle
Hemoglobin Gelatin by Phenyl Derivatives and Other Known Agents.
Biochem., 18(19):4196-4201 (1979)
Benson, G.A.; Spillane, W.J.
H Gas Chromotography Determination of Cyclic Amines, Ketones, and
Alcohols - Possible Metabolites of Sweet Sulphamates.
J. Chromatgr., 136(2):318-22 (1977)
Berenblum, I.
H Report on Cyclamates by the Committee Set up by the Israel
Ministry of Health.
Isr. J. Med. Sci., 6(4):576-9 (1970)
Berglund, F.
H Food Additives.
Arch. Toxicol. (Suppl), 1:33-46 (1978)
Berglund, F.; Sjoedin, L.
H Cyclamate and Cyclohexylamine - Sweet and Bitter.
Lakartidningen, 68(35):3873-88 (1971)
Beritic, T.; Dimov, D.
H Cyclamate between Facts and Suspicions.
Med. J., 91(ll):54-7 (1970)
Bernhard, K.
H Metabolic Hydrogenation of the Cyclohexane Ring.
Z. Physiol. Chem., 248:256-76 (1937)
Berry, C.T.; Crossland, R.J.
E An Automated Method for the Determination of Cyclohexylamine in
Cyclamates.
Analyst (London), 95(1128):291-5 (1970)
Bickel, M.H.
H Conditions of Cyclohexylamine Formation in Rats Chronically
Ingesting Cyclamate.
Experientia, 28(6):741-2 (1972)
Bickel, M.H.
H Present Status of the Question of Toxicity of Cyclamate and
Saccharin.
Ther. Umsch., 31(10):755-7 (1974)
Bickel, M.H.; Burkard, B.; Merier-Strasser, E.
H Entero-Bacterial Formation of Cyclohexylamine in Rats Ingesting
Cyclamate.
Xenobiotica, 4(7):425-39 (1974)
13
-------
Bisz-Konarzewska, A.
E The Effect of Cyclohexane Derivatives on Selection of Bacterial
Groups Forming Activated Sludge Microflora.
Acta Microbiol. Pol., 27(2):155-60 (1978)
Bisz-Konarzewska, A.; Dylinski, M.
E Treatment of Sewage Containing Cyclohexane Derivatives by
Activated Sludge Method.
Gaz. Woda Tech. Sanit., 52(l):25-7 (1978) (Pol)
Blumberg, A.G.; Meaton, A.M.
E The Occurrence of Cyclohexylamine in Urine Studies for Drug Use
by Thin-Layer Chromatography.
J. Chromatogr., 48(3):565-6 (May 6, 1970)
Bogatskii, A.V.; Golovenko, N. Y.
H Role of Stereochemical Factors in Drug Metabolism.
Vopr. Stereokhimii. Resp. Mezhved. Nauchn. Sb., (6):3-16 (1977)
(Rus)
Bradford, E., Weston, R.E.
E The Determination of Cyclohexylamine in Cyclamates.
Analyst (London), 94(114):68-70 (Jan. 1969)
Bray, D.A.; Devita, V.T.; Adamson, R.H.; et al.
H Effects of l-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU;
NSC-79037) and Its Degradation Products on Progression of L1210
Cells through the Cell Cycle.
Cancer Chemother. Rep. Part 1, 55(3):215-20 (1971)
Bray, D.; Oliverio, V.5 Adamson, R.; et al.
H Cell Cycle Effects Produced by
l-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) and Its
Decomposition Products.
Proc. Am. Assoc. Cancer Res., 11:12 (1970)
Brewen, J.G.
H Host Mediated Cytogenetic Assay.
Mutat. Res., 31(l):5-8 (1975)
Brewen, J. G.
H Host-mediated Cytogenetic Assay.
Handb. Mutagenicity Test Proced., pp. 221-4 (1977)
Brewen, J.G.; Pearson, F.G.; Jones, K.P.; et al.
H Cytogenic Effects of Cyclohexylamine and N-OH-Cyclohexylamine on
Human Leucocytes and Chinese Hamster Bone Marrow.
Nature, 230(1): 15-6 (Mar. 3, 1971)
14
-------
Briller, S.; Gromet-Elhanan, Z.
E Effect of Ammonium Salts, Amines, and Antibiotics on Proton
Uptake and Photophosphorylation in Rhodosplrillum rubrum
Chromatophores.
Biochim. Biophys. Acta, 205(2):263-72 (1970)
Bringmann, G.
E Determination of the Biological Effect of Water Pollutants in
Protozoa. I. Bacteriovorous Flagellates. (Model Organism:
Entosiphon sulcatum Stejn).
Z. Wasser Abwasser Forsch., ll(6):210-5 (1978) (Ger)
Bringmann, G.; Kuehn, R.
E Comparative Results of the Damaging Effects of Water Pollutants
against Bacteria (Pseudomonas putida) and Blue Algae
(Microcystis aeruginosa).
Gas. Wasserfach Wasser Abwasser, 117(9):410-3 (1976) (Ger)
E Bringmann, G.; Kuehn, R.
Limiting Values for the Damaging Action of Water Pollutants to
Bacteria (Pseudomonas putida; and Green Algae (Scenedesmus
quadricauda) in the Cell Multiplication Inhibition Test.
Z. Wasser. Abwasser Forsch., 10(3-4):87-98 (1977) (Ger)
Bringmann, G.; Kuehn, R.
E Results of the Damaging Effect of Water Pollutants on Daphnia
magna.
Z. Wasser. Abwasser Forsch., 10(5):161-6 (1977) (Ger)
Bringmann, G.; Kuehn, R.
E Testing of Substances for Their Toxicity Threshold; Model
Organisms Microcystis (Diplocystis) aeruginosa and Scenesmus
quadricauda.
Symposium: Experimental Use of Algal Cultures in Limnology,
1976.
Mitt. Int. Ver. Theor. Angew. Limnol., 21:275-84 (1978)
Bringmann, G.; Kuehn, R.
E Comparison of the Toxicity Thresholds of Water Pollutants to
Bacteria, Algae, and Protozoa in the Cell Multiplication
Inhibition Test.
Water Res., 13(3):231-41 (1980)
Browning, E.
H Toxic Solvents; A Review.
Br. J. Ind. Med., 16:23-39 (1959)
Browning, L.S.
H Failure to Detect Mutagenicity by Injection of Cyclohexylamine
and N-Hydroxylcyclohexylamine into Drosophila.
EMS Newsl., 6:18-9 (1972)
15
OTS-IIC REPORT FILE
-------
Buffa, M.
H New Sweetening Agents.
Boll. Soc. Ital. Farm. Osp., 21(2):98-118 (1975) (Ita)
Bungard, 6.
H Sweeteners. V. Particular Problems, h. Circulatory Effect of
Endogenous Cyclohexylamine Resulting from Orally Administered
Cyclamate.
Dtsch. Apoth., 23(8):365-8 (1971) (Ger)
Bungard, G.
H Errors in the Carcinogenic Effects of Saccharin, Sodium
Saccharin, Cyclamates, Their Possible Metabolites, and
Cyclohexylamine, As Well As Mixtures of 10 Parts Sodium
Cyclamate and 1 Part Sodium Saccharin. I. Saccharin and Sodium
Saccharin.
Dtsch. Apoth., 25(12):738, 740-2, 747, 749-50, 752-3 (1973) (Ger)
Bungard, G.
H Lack of Carcinogenic Effect by Saccharin, Saccharin Sodium,
Cyclamates, Cyclohexylamine, and Their Possible Metabolites As a
Mixture of 10 Parts Sodium Cyclamate and 1 Part Saccharin
Sodium. III. Cyclamates.
Dtsch. Apoth., 26(2):66-73 (1974) (Ger)
Bungard, G.
H Lack of Carcinogenic Activity for Saccharin and Saccharin
Sodium, Cyclamates, Their Possible Intermediate Metabolite
Cyclohexylamine, and Mixture of 10 Parts Sodium Cyclamate to 1
Part Saccharin Sodium. IV. Cyclohexylamine.
Dtsch. Apoth., 26(3):117, 119-20, 122 (1974) (Ger)
Bungard, G.
H Problem of Mutagenicity of Sweetening Agents. III. Cyclamate
Sweetening Agents.
Dtsch. Apoth., 27(8):322, 324-6 (1975) (Ger)
Bungard, G.
H On the Question of the Mutagenicity of Sweeteners. 4.
Cyclohexylamine.
Dtsch. Apoth., 28(4):152-64 (1976) (Ger)
Burbank, F.; Fraumeni, J.F.
H Synthetic Sweetener Consumption and Bladder Cancer Trends in the
United States.
Nature (London), 227(5255):296-7 (1970)
Butterworth, K.R.; Gangolli, S.D.; Guant, I.F.; et al.
H Long-Term Toxicity of Cyclohexylamine Hydrochloride in the Rat.
Food Cosraet. Toxicol., 14(4):255 (Aug. 1976)
16
-------
Butterworth, K.R.; Gaunt, I.F.; Hoosan, J.; et al.
H Long-Term Toxicity of Cyclohexylamine Hydrochloride in Mice.
Food Cosmet. Toxicol., 14(4):269 (Aug. 1976)
Calandra, J.C.; Plank, J.; Keplinger, M.L.; et al.
H Two Year Chronic Oral Toxicity of Cyclohexylamine Sulfate in
Albino Rats.
Industrial Bio-Test Laboratories, Inc. Northbrook, IL (1967-69)
Carr, J.V.; Hybner, C.J.; Wragg, J.B.
H Effect of Calcium Cyclamate and Cyclohexylamine on the Synthesis
of Pyrimidine Nucleotidea DNA and RNA in Cultured Human Lung
Cells.
J. Cell Biol., 47(2 Pt. 2):30A-31A (1970)
Cattanach, B.M.
H The Mutagenicity of Cyclamatea and Their Metabolites.
Mutat. Res. (Netherlands), 30(1):1-28 (1976)
Cattanach, B.M.; Pollard, C.E.
H Mutagenicity Tests with Cyclohexylamine in the Mouse.
Mutat. Res., 12(4):472-4 (1971)
Chauhan, P.S.; Aravindarkshan, M.; Chauboy, R.C.; et al.
H An Investigation on the Induction of Dominant Lethal Mutations
in Cyclohexylamine Treated Mice.
Proceedings: Symposium on Mutagenicity, Carcinogenicity, and
Teratogenicity of Chemicals. Baroda, India, Dec. 4-6, 1975.
Programme and Abstracts, pp. 34-44. Department of Atomic
Energy, Bombay, India (1975)
Chaykovsky, M.; Brown, B.L.; Modest, E.J.
H Methotrexate Analogs. 6. Replacement of Glutamic Acid by
Various Amino Acid Esters and Amines.
J. Med. Chem., 18(9): 909-12 (1975)
Chen, J.Y.T.; Gould, J.H.
E Infrared Studies of Cyclohexylamine.
J. Assoc. Off. Anal. Chem., 55(5):1006-14 (1972)
Chu, E.H.Y.; Bailiff, E.G.
H Mutagenicity Test of the Metabolic Derivatives of Cyclaraates in
Mammalian Cell Cultures.
EMS Newsl., 3(39) (1970)
Chuang, R.Y.; Laszlo, J.; Keller, P.
H Effects of Nitrosoureas on Human DNA Polymerase Activities from
Acute and Chronic Granulocytic Leukemia Cells.
Biochim. Biophys. Acta (Netherlands), 425(4):463-8 (1976)
17
-------
Classen, H.G.
H Effect of Cyclohexylamine on Blood Circulation and Nictitating
Membrane of Cats during Enteral Administration, after
Extirpation of the Adrenal Glands As Well As after Pretreatment
with Cocaine and Resperpine.
Arzneim. Forsch., 18(9):1191-5 (Sept. 1968) (Ger)
Classen, H.G.
H Effect of Quanethidine and Cyclazenine on the Sympathomimetic
Effect of Cyclohexylamine.
Arzneim. Forsch., 19(6): 92 9-32 (Jun. 1969) (Ger)
Classen, H.G.; Gardell, C.; Kovacs, K.; et al.
H Electrocardiographic and Histologic Changes in the Adrenergic
Cadiopathy Aggravated by Cyclohexylamine.
Arzeim. Forsch., 20(l):27-9 (Jan. 1970) (Ger)
Classen, H.G.; Marquardt, P.
H Cyclohexylamine.
Dtsch. Apoth., 109(15):548 (1969) (Ger)
Classen, H.G.; Marquardt, P.
H On the Pharmacology of Cyclohexylamine, a Substance Found in
Human Urine after Intake of Cyclamates.
Naunyn Schmiedebergs Arch. Pharmacol., 263(l):263-4 (1969) (Ger)
Classen, H.G.; Marquardt, P.
H Pharmacology of Cyclohexylamine. A Product Found in Human Urine
after Cyclamate Intake.
Klin. Wocherschr., 47(4):223-5 (Feb. 15, 1969) (Ger)
Classen, H.G.; Marquardt, P.
H Formation, Pharmacology, and Toxicology of the Cyclohexylamines
- Starting Product for the Synthesis of Cyclamates.
Ernaehr. Umsch., 19(1): 13-7 (Jan. 1972) (Ger)
Classen, H.G.5 Marquardt, P.; Schoeffel, E.; et al.
H Circulatory Reactions and Blood Flow Changes in Cats after
Administration of Cyclohexylamine.
Arzneim. Forsch., 21(4):489-96 (1971) (Ger)
Classen, H.G.; Marquardt, P.; Solymoss, B.; et al.
H The Influence of Cyclohexylamine on Experimental Cardiac
Necrosis and Blood Flow.
Naunyn Schmiedebergs Arch Pharmakol., 266(4-5):310-1 (1970)
Classen, H.G.; Marquardt, P.; Speath, M.
H Sympathomimetic Effects of Cyclohexylamine.
Arzneim. Forsch., 18(5):590-4 (1968) (Ger)
18
-------
Classen, H.G.; Solymoss, B.; Varga, S.
H Aggravation of Adrenergic Cardiopathy by Cyclohexylamine.
Arzneim. Forsch., 19(11):1805-7 (1969) (Ger)
Classen, H.G.; Solymoss, B.; Varga, S.
H Influence of Cyclohexylamine on the Andrenergic Cardiopathy.
Can. J. Physibl. Phannacol., 48(4):226-31 (1970)
Classen, H.G.; Spaczynski, K.
H Effect of Cyclohexylamine on Isolated Strips of Guinea Pig Aorta.
Arzneim. Forsch., 19(6):928-9 (1969) (Ger)
Cobley, J.G.
E Energy-conserving Reactions in Phosphorylating
Electron-Transport Particles from Nitrobacter winogradskyi.
Activation of Nitrite Oxidation by the Electrical Component of
the Protonmotive Force.
Biochem. J., 156(3):481-91 (Jun. 15, 1976)
Cobley, J.G.
E Reduction of Cytochromes by Nitrite in Electron-Transport
Particles from Nitrobacter winogradskyit Proposal of a
Mechanism for H+ Translocation.
Biochem. J., 156(3):493-8 (Jun. 15, 1976)
Ceilings, A.J.
H Metabolism of Sodium Cyclamate.
Proceedings: Ind. Univ. Coop. Symposium on Sweetness and
Sweeteners. Edited by Birch, G.G. London, England:
Appl. Sci. Publ. Ltd., pp. 51-68 (1971)
Cook, C.E.
H Cyclamatea; A Review of the Current Position.
Curr. Med. Res. Opin., 3(4):218-24 (1975)
Cooper, P.
H Resolving the Cyclamate Question.
Food Cosmet. Toxicol., 15(1):69-70 (1977)
Cramer, G.M.; Ford, R.A.; Hall, R.L.
H Estimation of Toxic Hazard - A Decision Tree Approach.
Food Cosmet. Toxicol., 16(3):255-76 (1978)
Dalderup, L.M.; Keller, G.H.; Schouten, F.
H Cyclamate and Cyclohexylamine.
Lancet, 1(651):845 (Apr. 18, 1970)
. David, T.R.A.; Adler, N.; Opsahl, J.C.; et al.
H Excretion of Cyclohexylamine in Subjects Ingesting Sodium
Cyclamate,
Toxicol. Appl. Pharmacol., 15(1):106-16 (Jul. 1969)
19
-------
De la Torre Boronat, M.C.; Camprubi Ribalta, M.
H Detection of Sweeteners in Aromatic and Nonalcoholic Commercial
Beverages.
Circ. Farm., 30(235):231-42 (1972) (Spa)
Dengler, H.J.
H Fate of Cyclamate in Organisms.
Wiss. Veroeff. Deut. Ges. Ernaehr., 20:93-100 (1971) (Ger)
Dengler, H.J.
H How Can Metabolic Processes Influence the Action of Orally
Admnistered Drugs (Cardiac Glycosides Sympathomimetic Amines,
CyclamateT?
Chem. Biol. Interactions, 3(4):317 (1971)
Dengler, H.J.
H Pharmacokinetics at the Present Time.
Internist, 19(6):333-9 (1978) (Ger)
Di Carlo Vodicarlo, V.
H Controlled Trial of Drugs with Antispastic and
Antispastic-Analgesic Action.
Clin. Ter., 70(5):451-63 (1974) (Ita)
Dick, C.; Biava, C.G.
H Comparison of Chromosomal Patterns Obtained from Rats Given
Cyclohexylamine by Different Routes.
EMS Newsl., 3:40-1 (1970)
Dick, C.E.; Schniepp, M.L.; Bonders, R.C.J et al.
H Cyclamate and Cyclohexylamine: Lack of Effect on the
Chromosomes of Man and Rats In Vivo.
Mutat. Res., 26(3):199-203 (Jun. 1974)
Didenko, M.N.
H Pathohistological Changes in the Body of Animals under the
Action of the Oil-Soluble Salt of Cyclohexylamine.
Vrach. Delo, 5:133-6 (May 1974) (Rus)
DiModica, G.
H Hematoporphyrinamine Complexes.
Italy, Patent No. 2299864
Mar. 9, 1976
Dixon, C.H.
H In Vitro Effects of Sodium-Cyclamate and Calcium-Cyclamate,
Cyclohexylamine, and Sucrose on Growth Rate and Chromosomes of
Chinese Hamster Fibroblasts.
Dissertation for Ph.D. Okalahoma State University (1972)
Diss. Abstr. Int., 33(12-8):5933-6066 (1973)
20
-------
Drasar, B.S.; Renwick, A.G.; Williams, R.T.
H The Conversion of Cyclamate into Cyclohexylamine by Gut Bacteria.
Biochem. J., 123(4):26-7 (Jul. 1971)
Drasar, B.S.; Renwick, A.G.; Williams, R.T.
H Role of the Gut Flora in the Metabolism of Cyclamate.
Biochem. J., 129(4):881-90 (1972)
Drummond, D.B.; Vasiloff, G.N.; Hill, A.W.
E Live Steam Humidification As a Source of Phytotoxic Contaminants
in Controlled Environment Growth Chambers and Greenhouse.
Proc. Am. Phytopathol. Soc., 1:135 (1975)
DuPuis, R.N.; Kusterer, J.E.; Sproull, R.C.
E Evaluation of Langwell's Vapor Phase Deacidification Process.
Lib. Congress Inform. Bull., pp. A41-3 (Jun. 4, 1970)
Eichelbaum, M.; Hengstmann, H.J.
H Specific and Sensitive Method for Determination of
Cyclohexylamine in Biological Fluids.
Arch. Toxikol., 27(2):136-41 (1971) (Ger)
Eichelbaum, M.; Hengstmann, H.J.; Dengler, H.J.
H Effect of Cyclohexylamine on Noradrenaline Uptake and Content in
the Rat Heart.
Naunyn Schmiedebergs Arch. Pharmakol., 267(4):353-63 (1970) (Ger)
Eiehelbaum, M.; Hengstmann, J.H.; Rost, M.D.; et al.
H Pharmacokinetic, Cardiovascular, and Metabolic Actions of
Cyclohexylamine in Man.
Arch. Toxikol., 31(3):243-63 (Feb. 28, 1974)
Elliott, T.H.; Lee-Yoong, N.Y.; Tao, R.C.C.
H The Metabolism of Cyclohexylamine in Rabbits.
Biochem. J., 109(2):ll-2. (1968)
Epstein, S.S.; Arnold, E.; Andrea, J.; et al.
H Detection of Chemical Mutagens by the Dominant Lethal Assay in
the Mouse.
Toxicol. Appl. Pharmacol., 23:288-325 (1972)
Ermilova, I.A.; Kanevskaya, I.G.; Semenyuk, V.I.
E The Effect of Corrosion Inhibitors on the Microbiological
Stability of Metallic Articles for Domestic Use and Their
Packing.
Mikol. Fitopatol., 12(2):180-1 (1978) (Rus)
Fazio, T.; Howard, J.W.; Haenni, E.O.
E Survey of Cyclohexylamine Content of Food Products Containing
Cyclamates.
J. Assoc. Off. Anal. Chem., 53(6):1120-8 (1970)
21
-------
Feldman, J.M.; Lebovitz, H.E.
H The Nature of the Interaction of Amines with the Pancreatic Beta
Cell to Influence Insulin Secretion.
J Pharmacol. Exp. Ther., 179(1):56-65 (1971)
Felix, R.; De la Rosa, M.E.
H Cytogenetic Studies with Cyclohexylamine in D. melanogaster
Females.
Dros. Info. Serv., 47:114-6 (1971)
Filer, L.J. Jr.
H Placental Transmission of Chemicals in the Subhuman Primate.
Pediatrics, 53(5 Pt.2):823-4 (1974)
Filov, V.A.
H A Study of the Behavior of Cyclohexylamine and Dicyclohexylamine
in the Body.
Gig. Tr. Prof. Zabol., 12(7):29-33 (1968)
Fishbein, L.; Flamm, W.G.; Falk, H.L.
H Drugs, Food Additives, Pesticides, and Miscellaneous Mutagens.
In: Chemical Mutagens. Environmental Effects on Biological
Systems. London: Academic Press, pp. 235-306 (1970)
Fluck, E.R.; Poireir, L.A.; Ruelius, H.W.
H Evaluation of a DNA Polymerase-Deficient Mutant of E. coli for
the Rapid Detection of Carcinogens.
Chem. Biol. Interact., 15:219-31 (1976)
Friedman, C.D.; Harbision, R.D.; Jones, M.M.; et al.
H Toxicity of Chelated Mercury.
J. Environ. Pathol. Toxicol., 2(6):1529-37 (1979)
Fromm, F.
E The Toxicity of Some Amines for Duckweed (Lemna minor).
Ohio Jour. Sci., 58(6):354-6 (1958)
Gall, D.
H The Adjuvant of Aliphatic Nitrogenous Bases.
Immunology, 11(4):369-86 (1966)
Gananca, M.; Trabulsi, L.R.
H The Therapeutic Effects of Cyclacillin in Acute Sinusitis; In
Vitro and In Vivo Correlations in a Placebo-controlled Study.
Curr. Med. Res. Opin., 1(6):362-8 (1973)
Garshenin, V.F.; Kryatov, I.A.; Osintseva, V.P.; et al.
H Sanitary-Toxicological Characteristics of Inhibitors of
Atmospheric Corrosion.
Gig. Vody Sanit. Okhr. Vodoemov., pp. 81-6 (1973) (Rus)
22
-------
Carton, R.B.
E Biological Effects of Cooling Tower Slowdown.
Symposium: Water-1972.
AIChE Symp. Ser., 69(129):284-94 (1978)
Gaunt, I.P.; Hardy, S.D.
H Short-Term Toxicity of Violet 6B (FB and C Violet No. 1) in the
Rat.
Food Cosmet. Toxicol., 12(1):11-9 (1974)
Gaunt, I.P.; Hardy, J.; Grasso, P.; et al.
H Long-Term Toxicity of Cyclohexylamine Hydrochloride in the Rat.
Food Cosmet. Toxicol., 14(4):255-67 (1976)
Gaunt, I.P.; Sharratt, M.; Grasso, P.; et al.
H Short-Term Toxicity of Cyclohexylamine Hydrochloride in the Rat.
Food Cosmet. Toxicol., 12(5-6):609-24 (1974)
Ghiani, P.; Muratori, R.A.
H Teratogenesis in Chick Embryos Caused by Cyclamates.
Ricerca Scientifica, 38(12);1260-6 (1969) (ita)
Gibson, J.E.; Becker, B.A.
H Teratogenicity of Structural Truncates of Cyclophosphamide in
Mice.
Teratology, 4:141-50 (1971)
Gieldanowski, J.; Bobranski, B.; Deckert, J.; et al.
H Malonyl and Succinyl Dicyclohexylamides and Allied Compounds As
Potential Antiinflammatory Agents.
Farmaco. Ed. Sci., 29(2):81-94 (1974)
Click, S.D.; Cox, R.D.; Maayani, S.; Meibach, R.C.
H Anticholinergic Behavioral Effect of Phencyclidine.
Eur. J. Pharmacol., 59(l-2):103-6 (1979)
Glogner, P.; Matthis, W.; Kamm, G.
H Frequency of Excretion of Cyclohexylamine Following Oral
Administration of Sodium Cyclamate.
Med. Welt, 29:1335 (1970)
Tag. Dtsch. Ges. Inn. Med. (Wiesbaden), 76:141 (1970) (Ger)
Goettinger, E.
H Toxicology of Chemical Sweetening Agents.
Wien. Med. Wochenschr., 121(25-26):515-6 (1971)
Goldberg, L.5 Parekh, C.; Patti, A.; et al.
H Cyclamate Degradation in Mammals and In Vitro.
Proceedings: 8th Annual Meeting of the Society of Toxicology.
Institute of Experimental Pathology and Toxicology. Albany
Medical College. Williamsburg, VA, Mar. 10-12, 1969
Toxicol. Appl. Pharmacol., 14:654 (1969)
23
-------
Gondry, E.
H Diabetogenic Action of Cyclohexylamine.
Ann. Endocrinol., 32(5):711-5 (1971) (Fre)
Gondry, E.
H Research on the Toxicity of Cyclohexylamine, Cyclohexanone, and
Cyclohexanol, Cyclamate Metabolites.
J. Eur. Toxicol., 5(4):227-38 (1972)
Gonzaga, A.J.; Antonio-Velmonte, M.; Tupasi, T.E.
H Cyclacillin; A Clinical and In Vitro Profile.
J. Infect. Dis., 129(5):545-51 (1974)
Gordienko, V.M.; Didenko, M.N.
H An Electron Microscopic Study of the Rat Liver under the Action
of Dicyclohexylamine Nitrite and a Low Solubility
Cyclohexylamine Salt.
Cytol. Genet., 11(1):68-70 (1977)
Tsitol. Genet., ll(l):76-8 (1977) (Russ)
Gordienko, V.M.; Didenko, M.N.
H Ultrastructure of the Rat Adenohypophysis under the Effect of
Some Amines of the Polymethane Series.
Tsitol. Genet., 11(3):268-71 (1977) (Rus)
Grasso, P.; Hardy, J.; Gaunt, I.F.; et al.
H Long-Term Toxicity of Violet 6B (FD and C Violet No. 1) in Mice.
Food Cosmet. Toxicol., 12(1):21-31 (1974)
Green, S.
H Cytogenetic and Dominant-Lethal Effects of Cyclohexylamine.
EMS Newsl., 3:38-9 (1970)
Green, S.; Palmer, K.A.; Legator, M.S.
H In Vitro Cytogenetic Investigation of Calcium Cyclamate,
Cyclohexylamine, and Triflupromazine.
Food. Cosmet. Toxicol., 8(6):617-23 (Dec. 1970)
Green, S.; Palmer, K.A.; Legator, M.S.
H Effects of Cyclohexylamine on the Fertility of Male Rats.
Food Cosmet. Toxicol., 10(1):29-34 (1972)
Gunner, S.W.; O'Brien, R.C.
Note on Detection and Quantitative Analysis of Cyclohexylamine.
J. Assoc. Off. Anal. Chem., 52(6):1200-2 (Nov. 1969)
Haigh, J.C.; Haigh, J.M.
H Immobilizing Drug Emergencies in Humans.
Vet. Hum. Toxicol., 22(1):1-5 (1980)
24
-------
Hamptom, C.M.; Myers, R.L.
H The Effect of Calcium Cyclamate on Immune Factors in Rabbits.
Symposium: Annual Meeting of the American Society of
Microbiologists, 1975.
Hampton, C.M.; Meyers, R.L.
H Effects of Cyclamate Calcium on the Immune Response in Rabbits.
Arch. Environ. Health, 31(l):51-3 (Jan. - Feb. 1976)
Hardy, J.; Gaunt, I.F.; Hooson, J.; et al.
H Long-Term Toxicity of Cyclohexylamine Hydrochloride in Mice.
Food Cosmet. Toxicol., 14(4):269-76 (Aug. 1976)
Harrell, W.B.; Kuang, S.W.; O'Dell, C.
H New Compounds: Mannich Bases from 1,2-Diphenylindolizine
N-Substituted Cyclohexylaminomethyl Derivatives.
J. Pharm. Sci., 59:721-2 (May 1970)
Hayashi, N.; Iwahara, S.; Tanimara, A.; et al.
H Studies on the Metabolism of Sodium Cyclohexylsulfamate. II.
In Vitro Conversion of Sodium Cyclohexylsulfamate to
Cyclohexylamine in Livers of Monkey, Rabbit, Guinea Pig> and Rat.
Bull. Natl. Inst. Hyg. Sci. (Tokyo), 90:43-8 (1972) (Jpn)
Hayashi, N.; Iwahara, S.; Tanimura, A.; et al.
H Studies on the Metabolism of Sodium Cyclohexylsulfamate. I. On
Urinary Excretion of Cyclohexylamine in Monkey and Effect of
Administration of Feces of Cyclohexylamine-excreting Monkey and
Commercial Diet to Rabbit, Guinea Pig, and Rat.
Bull. Natl. Inst. Hyg. Sci. (Tokyo), 91:11-8 (1973) (Jpn)
Hengstmann, J.H.; Dengler, H.J.; Geipert, F.
H The Conversion of Cyclamate to Cyclohexylamine in 255 Diabetic
and Obese Patients.
Naunyn Schmiedebergs Arch. Pharmacol., 282(suppl.) (Mar. 22,
1974)
Hengstmann, J.; Eichelbaum, M.; Dengler, H.J.
H Pharmacokinetic Properties and Cardiovascular Actions of
Cyclohexylamine in Human Beings.
Naunyn-Schmiedebergs Arch. Pharmakol., 270(Suppl.) (1971)
Henri, A.; Klastersky, J.
H Comparative Evaluation of Cyclacillin and Ampicillin in Urinary
Tract Infections. A Double-Blind Study.
Chemotherapy, 20(2):102-12 (1974)
Herbold, B.A.; Lorke, D.
H On the Mutagenicity of Artificial Sweeteners and Their Main
Impurities in the Salmonella/Microsome Test.
Mutat. Res., 74(2):155-6 (1980)
25
-------
Heywood, R.; James, R.W.
H Assessment of Testicular Toxicity in Laboratory Animals.
Environ. Health Perspect., (24):73-80 (1978)
Hibasami, H.; Tanaka, M.; Nagai, J.; et al.
H PiCyclohexylamine - A Potent Inhibitor of Spermidine Synthase in
Mammalian Cells.
Fed Eur. Biochem. Soc. Lett., 116(l)s99-101 (1980)
Hill, B.F.
H Testing Chemical Mutagens; The Dominant Lethal Assay.
Charles River Digest, 15(2):4 pp. (1976)
Holmlund, L.G.; Taernvik, A.
H Cytotoxic Investigation of Cyclohexylamine and Decylamine, Two
Corrosion Inhibitors.
Odontol. Revy, 14(4):335-41 (1963)
Howard, J.W.; Fazio, T.; Klineck, B.A.; et al.
E Determination of Cyclohexylamine in Various Artificially
Sweetened Foods and Artificial Sweeteners.
J. Assoc. Off. Anal. Chem., 52(3):492-500 (1969)
Hrdlicka, J.; Janicek, G.
E Study of Changes during Thermal and Hydrothermal Processing.
XVI. Paper Chromatographic Detection of Cyclohexylamine
Formation during Decomposition of Sodium Cyclamate under Various
Heating Conditions.
Z. Lebensm. Unters. Forsch., 145(5):291-3 (1971)
Ichibagase, H.; Kojima, S.; Inoue, K.; et al.
H Synthetic Sweetening Agents. XV. Metabolism of Sodium
Cyclamate. 4. Influences of Phenylbutazone, Phenobarbital, and
Tolbutamide on the Metabolism of Sodium Cyclamate in Rabbits.
Chem. Pharm. Bull., 20(1):175-80 (1972)
Ichibagase, H.; Kojima, S.; Suenaga, A.; et al.
H Synthetic Sweetening Agents. XVI. Metabolism of Sodium
Cyclamate. 5. Metabolism of Sodium Cyclamates in Rabbits and
Rats after Prolonged Administration of Sodium Cyclamate.
Chem. Pharm. BullT, 20(6);1093-101 (1972)
H Inagami, T.; York, S.S.
Effect of Alkylguanidines and Alkylamines on Trypsin Catalysis.
Biochemistry, 7(11):4045-52 (1968)
Industrial Bio-Test Laboratories, Inc.
H Two-Year Chronic Oral Toxicity of Cyclohexylamine Sulfate-Beagle
Dogs.
Industrial Bio-Test Labs, Inc., 1810 Frontage Rd., Northbrooks,
IL 60062 (Aug. 26, 1969)
26
-------
Izui, K.; Nishikido, T.; Ishihara, K.; et al.
H Allosteric Effectors and Some Properties of Phosphoenolypyruvace
Carboxylase from Escherichia coli.
J. Biochem. (Tokyo), 68(2):215-26 (1970)
Jackson, C.D.; Baetcke, K.P.
H Causative Agents in the Induction of Bladder Cancer.
Ann. Clin. Lab. Sci., 6(3):223-32 (1976)
Janseen, W.; Kreutzig, L.; Schulze, V.; et al.
H Methods for Determining the Legal Purity Requirements for the
Sweetening Agents Saccharin, Sodium Saccharin, and Sodium
Cyclamate. Part II. Sodium Cyclamate.
Dtsch. Apoth., 29(4) :174-90 (1977) (Ger)
Johnson, D.E.; Nunn, H.B.
E Determination of Cyclamates (Sodium and Calcium Salts) in Canned
Fruits.
J. Assoc. Off. Anal. Chem., 51(6):1274-7 (1968)
Juhnke, I.; Luedemann, D.
E Results of the Study of 200 Chemicals Compounds on Acute Fish
Toxicity Using the Golden Orfe Test.
Z. Wasser Abwasser Forsch., ll(5):161-4 (1978) (Ger)
Jukes, T.H.
H Cyclamate Sweeteners.
J. Am. Med. Assoc. 236(17):1987-9 (1976)
Jungclaus, G.A.; Games, L.M.; Hites, R.A.
E Identification of Trace Organic Compounds in Tire Manufacturing
Plant Waste Waters.
Anal. Chem., 48(13):1894-6 (1976)
Kaziwara, K.; Mizutani, H.
H Teratological Studies of Cyclamate and Cyclohexylamine in Mice
.and Rats and Preliminary Cytogenetic Study in Mice of
Cyclohexylamine.
Takeda Chemical Ind., Ltd., Report (Mar. 26, 1970)
Kennedy, G.L.; Sanders, P.G.; Weinberg, M.S.; et al.
H Reproduction Studies in Rats and Rabbits with Cyclohexylamine
Sulfate.
Toxicol. Appl. Pharmacol., 14(3):656 (1969)
Khera, K.S.; Stoltz, D.R.
H Effects of Cyclohexylamine on Rat Fertility.
Experientia, 26(7):761-2 (1970)
27
-------
Khera, K.S.; Stoltz, D.R.; Gunner, S.W.; et al.
H Reproduction Study in Rats Orally Treated with Cyclohexylamine
Sulfate.
Toxicol. Appl. Pharmacol., 18(2):263-8 (Feb. 1971)
Khramov, V.A.
H Comparative Study of the Inhibition of Bacterial Agmatinase by
Putrescine and Aliphatic Monoamines.
Biochemistry, 42(31):352-5 (1977)
Kidman, C.D.; Mottram, D.R.; Hickman, J.A.
H Potentiation of the Response of Rat Vas Deferens to
Noradrenaline by Dicyclohexylamine and Related Amines.
Arch. Int. Pharmacodyn. Ther., 238(2):180-6 (1979)
Kikuchi, K.; Touchi, T.
H Pharmacological Characteristics of Cyclohexylamine, One of the
Metabolites of Cyclamate.
Life Sci., 8(15 Pt. l):843-53 (Aug. 1, 1969)
Knaap, A.G.A.C.; Kramers, P.G.N.; Sobels, F.H.
H Test for Mutagenic Effects of the Metabolic Products of
Cyclamate in Drosophila.
EMS Newsl., 6:26 (1972)
Knapp, A.G.A.C.; Kramers, P.G.N.; Sobels, F.H.
H Lack of Mutagenicity of the Cyclamate Metabolites in Drosophila.
Mutat. Res., 21(6):341-4 (1973)
Koizumi, A.; Tachibana, Y.; Dobashi, Y.; et al.
H Cytokinetic Study on Toxic Action of Sodium Cyclamate and
Cyclohexylamine.
Ind. Health, 9(4):188-93 (1971)
Kojima, S.; Ichibagase, H.
H Studies on Synthetic Sweetening Agents. 8. Cyclohexylamine, a
Metabolite of Sodium Cyclamate.
Chem. Pharm. Bull. (Tokyo), 14(9):971-4 (Sep. 1966)
Kojima, S.; Ichibagase, H.
H Studies on Synthetic Sweetening Agents. XII. The Binding of
Sodium Cyclamate with Bovine Serum Albumin.
Chem. Pharm. Bull. (Tokyo), 16:1619-22 (1968)
Kojima, S.; Ichibagase, H.
H Synthetic Sweetening Agents. XII. Metabolism of Sodium
Cyclamate. 2. Detection of Metabolites of Sodium Cyclamate in
Rabbits and Rats by Gas-Liquid Chromatography.
Chem. Pharm. Bull. (Tokyo), 16(9):1815-4 (1968)
28
-------
Kojima, S.; Ichibagase, H.
H Synthetic Sweetening Agents. XIV. Metabolism of Sodium
Cyclamate. 3. Metabolites of Sodium Cyclatnate in Humans.
Chem. Pharm. Bull., 17(12) -.2620-5 (1969)
Kon, S.H.
H Underestimation of Chronic Toxicities of Food Additives and
Chemicals: The Bias of a Phantom Rule.
Med. Hypotheses, 4(4):324-39 (1978)
Kragten, M.C.T.; Hogendoorn, A.M.; Gramberg, L.G.; et al.
H In Vivo Chromosome-damaging Effect of Cyclohexylamine in the
Chinese Hamster.
Food Cosmet. Toxicol., 13(4):415 (Aug. 1975)
Kroes, R.; Peters, P.W.J.; Berkvens, J.M.; et al.
H Long-Term Toxicity and Reproduction Study (including a
Teratogenicity Study) with Cyclamate, Saccharin, and
Cyclohexylamine. Mice.
Toxicology, 8(3):285-300 (Dec. 1977)
Kurebayashi, H.; Tanaka, A.; Yamaha, T.
H Oxidative Deamination of Cyclohexylamine and Its Homologs by
Rabbit Liver Microsomes.
Biochem. Pharmacol., 28(11):1719-26 (1979)
Lansdown, A.B.C.; Grasso, P.; Gaunt, I.F.; et al.
H Short-Term Toxicity of Cyclohexylamine Hydrochloride in the Rat.
Food Cosmet. Toxicol., 12(5-6):609 (Oct. 1974)
Leahy, J.S.; Taylor, T.; Rudd, C.J.
H Cyclohexylamine Excretors among Human Volunteers Given Cyclamate.
Food Cosmet. Toxicol., 5(4):595-6 (Oct. 1967)
Leahy, J.S.; Wakefield, M.; Taylor, T.
H Urinary Excretion of Cyclohexylamine Following Oral
Administration of Sodium Cyclamate to Man.
Food Cosmet. Toxicol., 5(3):447 (1967)
Le Dain, M.
H Cyclamates and Cyclohexylamine. Metabolism, Toxicity,
Identification, and Assay.
Rev. Corps Sante Armees, 12(3):313-43 (Jun. 1971) (Fre)
Lederer, J.
H Sweeteners; Saccharin; Cyclamate and Its Metabolites, Aspartame.
Rev. Med. Suisse Romande, 100(1):87-100 (1980) (Fre)
Lederer, J.; Collin, J.P.; Pottier-Arnould, A.M; et al.
H Cytogenetic and Teratogenic Action of Cyclamate and Its
Metabolites.
Sem. Ther., 47:357-63 (1971) (Fre)
29
-------
Lederer, J.; Pottier-Arnould, A.M.; Collin, J.P.; et al.
H Toxic, Cytogenetic, and Teratogenic Effects of Cyclamate and Its
Metabolic Derivatives.
Proceedings: Nat. Synth. Zusatzstoffe Nahr. Menschen. Int.
Symp., 1972. pp. 173-95 (1974)
Lee, I.P.; Dixon, R.L.
H Study of the Sympathomimetic Action of Cyclohexylamine, a
Possible Metabolite of Cyclamate.
J. Pharm. Sci., 57:1132-4 (1968)
Lee, I.P.; Dixon, R.L.
H Factors Affecting Cyclohexylamine Lethality in Mice.
Toxicol. Appl. Pharmacol., 14(3):654 (1969)
Lee, I.P.; Dixon, R.L.
H Various Factors Affecting the Lethality of Cyclohexylamine.
Toxicol. Appl. Pharmacol., 22(3):465-73 (1972)
Legator, M.; Palmer, K.A.; Green, S.; et al.
H Cytogenic Studies in Rats of Cyclohexylamine, a Metabolite of
Cyclamate.
Science, 165(3989):1139-40 (1969)
Lijinsky, W.; Reuber, M.D.
H Carcinogenicity of Deuterium-labeled
N-Nitroso-N-methylcyclohexylamine in Rats.
J. Natl. Can. Inst., 64(6):1535-6 (1980)
Litchfield, M.H.; Swan, A.A.B.
H Cyclohexylamine Production and Physiological Measurements in
Subjects Ingesting Sodium Cyclamate.
Toxicol. Appl. Pharmacol., 18(3):535-41 (1971)
Lomonova, G.V.
H Toxicity of Cyclohexylamine and Cyclohexylamine Carbonate.
Prom. Toksikol. Klinika Prof. Zabolevanii Khim. Etiol. Sb., pp.
160-3 (1962)
Lomonova, G.V.
H Toxicity of Cyclohexylamine and Dicyclohexylamine.
Gig. Tr. Prof. Zabol., 7(ll):51-6 (1963) (Rus)
Lomonova, G.V.
H Toxicity of Cyclohexylamine and Dicyclohexylamine.
Fed. Proc. (Trans. Suppl.), 24:96-8 (Jan.-Feb. 1965)
Lorke, D.; Machemer, L.
H Investigation of Cyclohexylamine Sulfate for Dominant Lethal
Effects in the Mouse.
Toxicology, 2(3):231-7 (Sep. 1974)
30
-------
Lorke, D.; Machemer, L.
H Influence of Several Weeks Treatment of Male and Female Mice
with Saccharin) Cyclamate, or Cyclohexylamine Sulfate on
Fertility and Dominant Lethal Effects.
Humangenetik, 26(3):199-206 (1975)
Lugovkin, B.P.; Zemlyanitskaya, E.T.
E Col primetrie Determination of Diethylamine, N-Butylamine, and
Cyclohexylamine in Air.
Nauch. Rab. Inst. Okhr. Tr. Vses. Tsent. Sov. Prof. Soyuzov.,
(58): 96-9 (1969) (Rus)
Ma, T.; Anderson, V.A.
E Micronuclei Induced by Ultraviolet Light and Chemical Mutagens
in Meiotic Pollen Mother Cells of Tradescantia.
Environ. Mutagenesis, 1:123-4 (1979)
Machemer, L.
H Mutagenicity Testing.
Ther. Gegw., 115:832-62 (1976) (Ger)
Machemer, L.; Lorke, D.
H Dominant Lethal Test in Female Mice. Effects of Alkylating
Agents and Artificial Sweeteners on Preovulatory Oocyte Stages.
Mutat. Res., 29(2):209-14 (1975)
Machener, L.; Lorke, D.
H Evaluation of the Mutagenic Potential of Cyclohexylamine on
Spermatogonia of the Chinese Hamster.
Mutat. Res., 40(3):243-50 (1976)
Malaiyandi, M.; Thomas, G.H.; Meek, M.E.
E Sampling and Analysis of Some Corrosion-Inhibiting Amines in
Steam Condensates.
J. Environ. Sci. Health, Part A, A14(7):609-27 (1979)
Mallette, F.S.; Von Haam, E.
H The Toxicity of Skin Effects of Compounds Used in the Rubber and
Plastics Industries. I. Accelerators, Activators, and
Antioxidants.
Arch. Ind. Hyg. Occup. Med., 5:311-7 (1952)
Marsh, D.F.
H Comparative Pharmacology.
J. Pharmacol., Exper. Therap., 93:338-45 (Jul. 1948)
Mason, P.L.; Thompson, G.R.
H Testicular Effects of Cyclohexylamine Hydrochloride in the Rat.
Toxicology, 8(2):143-56 (1977)
31
-------
Matsui, M.; Hayashi, N.; Kinuma, H.; et al.
H Detection of Cyclohexylamine Forming Bacteria from the
Intestinal Tract of Rabbit and Guinea Pig after Oral
Administration of Sodium Cyclamate. 5. Studies on the
Metabolism of Food Additives by Microorganisms Inhabiting the
Gastro-Intestinal Tract.
J. Food Hyg. Soc. Jpn., 21(2):129-40 (1980)
Matsui, M.; Hayashi, N.; Tanimura, A.; et al.
H Studies on Metabolism of Food Additives by Microorganisms
Inhabiting Gastro-Intestinal Tract. III. Suitable Medium for
the Production of Cyclohexylamine from Sodium Cyclamate by
Sodium Cyclamate Assimilating Bacteria under Anaerobic Culture
Condition.
J. Food Hyg. Soc. Jpn., 17(l):48-53 (1976) (Jpn)
Matsui, M.; Hayashi, N.; Konuma, H.; et al.
H Studies on the Metabolism of Food Additives by Microorganisms
Inhabiting Gastro-Intestinal Tract. IV. Fate of Faecal Flora
in Monkey, Administered Orally Sodium Cyclamate and Detection of
Sodium Cyclamate Assimilating Bacteria In Vitro by Anaerobic
Culture.
J. Food Hyg. Soc. Jpn., 17(l):54-8 (1976) (Jpn)
Matsumura, R.; Kohei, H.
H Studies on the Formation of Cyclohexylamine and
N-Methylcyclohexylamine from Bromhexine in Animals and Man and
Simultaneous Determination of Cyclohexylamine and
N-Methylcyclohexylamine by Gas Chromatograph^
J. Chromatogr., 117(2):383-91 (Feb. 18, 1976]
Maxted, E.B.; Biggs, M.S.
H Catalytic Toxicty of Nitrogen Compounds. I. Toxicity of
Ammonia and Amines.
J. Chem. Soc., pp. 3844-7 (1957)
Merdinger, E.
E Effect of Cyclamates on the Growth of Pullularia pollulans.
Can. J. Microbiol., 18(4):531-3 (1972)
Merdinger, E.; Bojor, 0.
E Effect of Cyclamic Acid and Its Sodium Salt in the Presence and
Absence of Glucose on the Growth of Pollularia pullulans.
Farmacia, 20(7) :3 95-401 (1972)
Mineo, L.; Figley, W.K.; Majumdar, S.K.
E The Effects of Sodium Cyclamate on the Growth of Chlamydomonas
reinhardi (Wild Type).
Proc. Pa. Acad. Sci., 49(2):103-6 (1975)
32
-------
Miyata, T.; Kase, Y.; Kamikawa, Y.; et al.
H Pharmacological Characteristics of Cyclohexylamine, One of the
Metabolites of Cyclamate.
Life Sci., 8(15):843-53 (1969)
Mostardi, R.A.; Keller, R.; Koo, R.
H Cytogenic Studies of Cyclohexylamine, a Metabolite of Cyclamate.
Ohio J. Sci., 72(6):313-8 (1972)
Niimura, T.; Tokieda, T.; Yamaha, T.
H Partial Purification and Some Properties of Cyclamate
Sulfamatase.
J. Biochem. (Tokyo), 75(2):407-17 (1974)
Noji, M.; Okamato, K.; Kidani, Y.
H Relation of Conformation to Anti-Tumor Activity of Platinum (II)
Complexes of 1,2-Cyclohexanediamine, and
2-(Aminomethy)-Cyclphexylamine Isomers against Leukemia P-388.
J. Med. Chem., 24(5) .'508-15 (1981)
Oliverio, V.T.; Vietzke, W.M.j Williams, M.K.; et al.
H Absorption, Distribution, Excretion, and Biotransformation of
the Carcinostatic l-2-(Chloroethyl)-3-cyclohexyl-l-nitrosourea
in Animals.
Cancer Res., 30(5):1330-7 (1970)
Omori, Y.; Kuwamura, T.; Tanaka, S.; et al.
H Experimental Studies on Cyclohexylamine in Relation to
Congenital Anomalies.
EMS News1., 3:30 (1970)
Onikienko, F.A.; Danstovskaia, V.V.
H Possibilities of Use of Certain Biochemical Tests for the
Detection of Adverse Affects of Amines of the Alicyclic Group.
Vrach. Delo, 4:124-7 (1974) (Rus)
Onikiyenko, F.A.; Torbin, V.F.
H Employment of Enzyme Tests in the Diagnosis of Intoxication with
Low-Soluble Cycloexylamine Salt.
Vrach. Delo. (U.S.S.R.), (2):97-9 (1980)
Oser, 8.L.
H FDRL Investigation of Cyclamates.
Hum. Pathoi., 6(1):130-2 (1975)
Oser, B.L.; Carson, S.; Cox, G.E.; et al.
H Chronic Toxicity Study of Cyclamate; Saccharin (10:1) in Rats.
Toxicology, 4(3):315-30 (1975)
33
-------
Oser, B.L.; Carson, S.; Cox, G.E.; et al.
H Long-Term and Multigeneration Toxicity Studies with
Cyclohexylamine Hydrochloride.
Toxicology, 6(l):47-65 (Jun. 1976)
Oser, B.L.; Carson, S.; Vogin, E.E.; et al.
H Conversion of Cyclamate to Cyclohexylamine in Rats.
Nature, 220(163):178-9 (Oct. 12, 1968)
Paustovskaya, V.V.; Krasnyuk, E.P.; Onikienko, F.; et al.
H Effect of Working Conditions on the Health of People Working
with Inhibitors of the Atmospheric Corrosion of Metals.
Vrach. Delo, (4):121-4 (1977) (Rus)
Paustovskaya, V.V.; Rappoport, M.B.
H The Toxicity of Cyclohexylamine Entering the Body through the
Skin.
Vrach. Delo., 1:149-50 (1966)
Paustovskaya, V.V.; Rozhovskaia, G.P..; Sova, R.E.; et al.
H Health-related Characteristics of the Working Condition during
Treatment of Metal Goods with NDA Inhibitor.
Gig. Tr. Prof. Zabol., 17(l):35-7 (1973) (Rus)
Paustovskaya, V.V.; Torbin, V.F.; Beznisko, T.G.
H Hygienic Characteristics of Working Conditions during Use of the
Inhibitor Cyclohexylamine.
Gig. Tr. Resp. Mezhved. Sb., (ll):66-8 (1975) (Rus)
Pawan, G.L.S.
H Dietary Cyclamate and Cyclohexylamine Excretion in Man.
Proc. Nutr. Soc., 29(10):10A-11A (1970)
Peterson, K.W.; Brandchaft, D.} Turner, M.; et al.
H Dominant Lethal Study in Mice Using Cyclohexylamine and
N-Hydroxycyclohexylamine.
Anat. Rec., 166:362 (1970)
Peterson, K.W.; Legator, M.S.; Figge, F.H.J.
H Dominant-Lethal Effects of Cychlphexylamine in C57BL/FE Mice.
Mutat. Res., 14:126-9 (Jan. 1972)
Pezet, R.; Gindrat, D.
E Injury to Plants Caused by Cyclohexylamine Vapors from
Silicone-Rubber in Growth Chambers.
Plant Dis. Rep., 62(2):100-4 (Feb. 1978)
Pitkin, R.M.; Reynolds, W.; Filer, L.J.
H Cyclamate and Cyclohexylamine; Transfer across the Hemochorial
Placenta.
Proc. Soc. Exp. Biol. Med., 132:993-3 (Dec. 1969)
34
-------
Pitkin, R.M.; Reynolds, W.; Filer, L.J.
H Placental Transmission and Fetal Distribution of Cyclamate in
Early Human Pregnancy.
Am. J. Obstet. Gynecol., 108:1043-50 (1970)
Fitter, P.; Kozderkova, M.
E Possibility of Biological Decomposition of Some Hydroaromatic
Compounds.
Int. Chem. Eng., ll(l):19-24 (Jan. 1971)
Pliss, G.B.
H The Carcinogenic Activity of Dicyclohexylamine (PCHA) and Its
Nitrite Salt.
Vopr. Onkol., 4(6):22-32 (1959) (Rus)
Pliss, G.B.
H The Carcinogenic Activity of Cyclohexylamine, Dicyclohexylamine,
and Dicyclohexylaminenitrite.
Vopr. Onkol., 4(6):659-69 (1958) (Rus)
Polacek, I.; Breuer, H.
H Hypoglycemic Activity of Amine Derivatives. Preliminary
Observations.
Arzniem. Forsch., 28(5):791-3 (1978)
Pontani, R.B.; Vadlamani, N.L.; Misra, A.L.
H Prolonged Excretion of a Metabolite in the Rat after a Single
Dose of Phencyclidine.
Res. Conmun. Subst. Abuse, l(4):469-72 (1980)
Price, J.M.: Biava, C.G.; Oser, B.L.; et al.
H Bladder Tumors in Rats Fed Cyclohexylamine or High Doses of a
Mixture of Cyclamate and Saccharin.
Science (Washington), 167 (3291):1131-2 (1970)
Prishchepov, V.F.; Fedyushina, N.A.
H Clinical and Morphological Characteristics of Occupational
Dermatoses Caused by Sulfenamide C.
Gig. Tr. Prof. Zabol., 4:34-7 (1975)
Prosky, L.; O'dell, R.G.
H The In-Vivo Conversion of Carbon-14 Labelled Cyclamate to
Cyclohexylamine and Other Metabolites in Rat.
Fed. Proc., 29(2):567 (1970)
J. Pharm. Sci., 60(9):1341-3 (Sep. 1971)
Rao, V.S.; Aiyar, A.S.
H Mutagenicity Evaluation Studies with Food Additives and
Radiolytic Products of Sugars.
Proceedings: Symposium on Mutagenicity, Carcinogenicity, and
Teratogenicity Chemistry, pp. 104-14 (1975)
35
-------
Reed, D.J.; May, H.E.; Boose, R.B.; et al.
H 2-Chloroethanol Formation As Evidence for a 2-Chloroethyl
Alkylating Intermediate during Chemical Degradation of
l-(2-Chloroethyl)-3-cyclohexyl-l-nitro8ourea and
l-(2-Chloroethyl)-3-(tran8-4-methylcyclohexyl)-l-nitrosourea.
Cancer Res., 35(3):568-76 (Mar. 1975)
Rees, D.I.
H Determination of Cyclamates in Soft Drinks.
Analyst, 90:568-9 (1965)
Renwick, A.G.; Williams, R.T.
H Gut Bacteria and the Metabolism of Cyclamate in the Rat.
Biochem. J., 114(4):78pp. (1969)
Renwick, A.G.; Williams, R.T.
H The Metabolism of Cyclamate.
Proceedings: 1st International Sugar Research Conference.
Brussels, Belgium.
International Sugar Research Foundation, Inc., pp. 3-14 (1970)
Renwick, A.G.; Williams, R.T.
H The Fate of Cyclamate in Man and Other Species.
Biochem. J., 129(4):869-79 (1972)
Renwick, A.G.; Williams, R.T.
H The Metabolites of Cyclohexylamine in Man and Certain Animals.
Biochem. J., 129(4):857-67 (Oct. 1972)
Rich, W.E.; Hetzel, R.A.
E Ion Chromatographic Analysis of Trace Ions in Environmental
Samples.
Symposium: 174th Meeting of the American Chemical Society.
Chicago, IL, Aug. 31, 1977.
American Chemical Society Symposium Ser. No. 94. Monitoring
Toxic Substances Edited by Schuetzle, D., pp. 233-46 (Pub. 1979)
Richardson, M.L.; Luton, P.E.
H Determination of Cyclamate in Soft Drinks by Gas Chromatography.
Analyst, 91:520 (1966)
Richmond, J.E.; Glaeser, R.M.; Todd, P.
H Protein Synthesis and Aggregation of Embryonic Cells.
Exp. Cell Res., 52(1):43-58 (1968)
Rosenblum, I.
H Responses to Cyclohexylamine in Animals (Abstract).
Toxicol. Appl. Pharmacol., 12(2):289 (1968)
36
-------
Rosenblum, I.; Rosenblum, G.
H Autonomic Stimulating and Direct Actions of Cyclohexylamine in
Isolated Tissues.
Toxicol. Appl. Pharmacol., 13(3):339-45 (Nov. 1968)
Rosenblum, I.; Rosenblum, G.
H Cardiovascular Responses to Cyclohexylamine.
Toxicol. Appl. Pharmacol., 12(2):260-4 (Mar. 1968)
Roxon, J.J.; Tesoriero, A.A.
H Effect of Cysteine on Cyclamate Metabolism by Rat Intestinal
Microorganism.
Aust. J. Pharm. Sci., 3(l):26-8 (1974)
Rozhkovskaya, G.P.
H Experimental Data on the Tpxicity of Oil-Soluble Salt of
pTcyclohexylamine (HSSD-11), Inhibitor of Atmospheric Corrosion
of Metals.
Vrach. Delo, (4):109-12 (1975) (Rus)
Sakai, A.; Kato, S.
E Ultramicro-Analysis of Cyclohexylamine and Low Fatty Amines by
Gas Chromatography.
Gac. Med. Mex., 96(5):37-41 (May 1966)
Sakai, T.; Miyahara, T., Muto, T.; et al.
E Fluorometric Determination of Ayclomate Using
l,2-Naphthoquinone-4-sulfonic Acid. II.
Eisei Kagaku, 20(l):20-3 (1974) (Jpn.)
Sapeika, N.
H The Toxicity of Foods of Natural Origin.
Trans. R. Soc. S. Afr., 41(1):1-17 (1974)
Sasaki, T.; Iwase, H.; likura, Z.
H Determination of Cyclamate in Seasoning Liquor.
Seasoning Science, 17(4):108:11 (1970) (Jpn)
Saturley, B.A.
H Colorimetric Determination of Cyclamate in Soft Drinks, Using
Picrylchloride.
J. Assoc. Off. Anal. Chem., 55(4):892-4 (1972)
Sarkar, S.; Banerjee, R.; Ise, M.S.; et al.
H Studies on Amine Oxidases. XVIII. Action of
2-Phenyl-cyclopropylamines on Monoamine Oxidase and Other Enzyme
Systems.
Helv. Chim. Acta., 43:439-47 (1960)
37
-------
Schenk, M.
H Unclassified Drugs.
In: Side Effects of Drugs. A Survey of Unwanted Effects of
Drugs Reported in 1968-71, Vol. 7. Edited by Meyler, L.;
Herxheimer, A., pp. 691-702, 1972
Schmaehl, D.
H Lack of Carcinogenic Effects of Cyclamate, Cyclohexylamine, and
Saccharin in Rats.
Arzneim. Forsch., 23(10);1466-70 (Oct. 1973) (Ger)
Schmaehl, D.
H Experiments in Rats on the Question of a Possible Carcinogenic
Effect of Cyclamate, Cyclohexylamine, Saccharin, and
Orthotoluolsulfonamide (OTS).
Proceedings: European Research Group for Oral Biology
Conference. Geneva, Switzerland, Oct. 30 - Nov. 1, 1978.
Health and Sugar Substitutes. Edited by Guggenheim, B., pp.
82-4 (Pub. 1979)
Schniepp, M.
H Mouse Dominant Lethal Test with Cyclohexylamine.
Abbott Laboratories Report.Chicago, IL (1973)
Schoeller, L.
H Chromosomal Effects of Cyclohexylamine.
Wiss. Veroeff. Dtsch. Ges. Ernaehr., 20:125-7 (1971) (Ger.)
Sharifyanova, L.N.
E Gas Chromatographic Determination of Cyclohexylamine in
Ammoniacal Water in Hexilure Production.
Metody Anal. Kontrolya Kach. Prod. Khim. Prom-sti., (6):6-7
(1978) (Rus)
Smirnov, K.
E Maximum Permissible Concentrations of Harmful Substances in the
Air of Industrial Premises.
Gig. Sanit., 28(9):124-5 (1963)
Smyth, H.F. Jr.; Carpenter, C.P.; Weil, C.S.; et al.
H Range-finding Toxicity Data. VII.
Am. Ind. Hyg. Assoc. J., 30(5):470-6 (1969)
Solomon, M.D.; Pereira, W.E.; Duffield, A.M.
E Determination of Cyclohexylamine in Aqueous Solutions of Sodium
Cyclamate by Electron-Capture Gas Chromatography.
Anal. Lett., 4(5):301-4 (1971)
Senders, R.C.; Estep, C.B.; Wiegand, R.G.
H Metabolism of Cyclohexylamine.
Fed. Proc., 27:238 (1968)
38
-------
Senders, R.C.; Netwal, J.C.j Wiegand, R.G.
H Site of Conversion of Cyclamate to Cyclohexylamine.
Pharmacologist, 11(2):241 (1969)
Senders, R.C.; Wiegand, R.G.; Netwal, J.C.
H Preservatives and Artificial Sweetener. Excretion of Cyclamate
in the Rat.
J. Assoc. Off. Anal. Chem., 51(1):136 (Jan. 1968)
Starr, D.F.
E The Action of a Repellent Spray against the Mexican Fruitfly.
J. Agric. Res., 71 (9):415-22 (1945)
Stockard, J.J.; Werner, S.S.; Aalbers, J.A.
H Electroencephalographic Findings in Cyclohexylamine-induced
Stupor and Coma - Clinical Studies of Acute Phencyclidine
Intoxication and Graded Intravenous Ketamine Infusion.
Electroencephalogr. Clin. Neurophysiol., 40(3):335 1976)
Stone, D.; Lamson, E.; Chang, Y.S.; et al.
H Cytogenic Effects of Cyclamates on Human Cells In Vitro.
Science, 1164:568-9 (1969)
Stone, D.; Matalka, E.; Riordan, J.
H Hyperactivity in Rats Bred and Raised on Relatively Low Amounts
of Cyclamates.
Nature (Lend.), 224(5226):1326-8 (1969)
SubbaRao, V.; Aiyar, A.S.
H Mutagenicity Evaluation Studies with Food Additives and
Radiolytic Products of Sugar.
Proceedings: Symposium on Mutagenicity, Carcinogenicity, and
Teratogenicity Chemistry. 1975, pp. 104-14 (Pub. 1975)
Svitel'skii, V.P.; Shuliak, E.V.; Kovba, V.A.
E Physiochemical Methods of Toxic Compound Removal from Technical
Paper Mill Effluents.
Proceedings: EUCEPA Symposium on Chemistry in Papermaking.
Warsaw, Poland, pp. 409-14 (Sep. 1978)
Swallow, W.H.
H Cyclohexylamine and Dicyclohexylamine Concentrations in
Non-Nutritive Sweetener and Foods Containing Non-Nutritive
Sweeteners.
N. Z. J. Sci., 18(4):541-6 (Dec. 1975)
Szokolay, A.
H Problems of Risk of Food Additives and Contaminants.
Prum. Potravin., 30(4):228-30 (1979) (Cze)
39
-------
Tada. 0.
E Methods for Determinations of Toxic Substances in Air-Organic
Compounds.
J. Sci. Labour, Part 2, 47(12):789-96 (1971)
Takahashi, T.; Watanabe, M.; Asahina, M.; et al.
H Fluorometric Determination of Cyclohexylamine in Biological
Samples.
Yakugaku Zasshi, 92(4):393-6 (1972) (Jpn)
Takamura, K.; Tanimura, A.
H Colorimetric Determination of Cyclohexylamine in Commercial
Sodium Cyclamate.
Bull. Nat. Inst. Hyg. Sci., 87:67-8 (1969) (Jpn)
Takano, K.; Omori, Y.
H Embryotoxicological Studies in Mice and Rats of Cyclohexylamine
a Metabolite of Cyclamate.
Symposium: Proceedings of the Congenital Anomalies Research
Association Annual Report. Congenital Anomalies, 10:3 (1971)
Takano, K.; Suzuki, M.
H Cyclohexylamine a Chromosome-Aberration Inducing Substance; No
Teratogenicity in Mice.
Congenital Anomalies, ll(2):51-7 (1971)
Tamaro, M; Venturini, S.; Monti-Bragadin, C.; et al.
H Effects in Bacterial Systems of Pt (II) Complexes with
Antitumour Activity.
Cheta. Biol. Interact., 26(2): 179-84 (1979)
Tanaka, S.; Kawashima, K.; Kuwamura, T.; et al.
H Effect of Cyclohexylamine on Rat Fetus.
Folia Pharmacol. Jpn., 66(6):176-7 (1970)
Tanaka, S.; Nakaura, S.; Kawashima, K.; et al.
H Studies on the Teratogenicity of Food Additives. 2. Effects of
Cyclohexylamine and Cyclohexylamine Sulfate on the Fetal
Development of Rats.
Shokuhin Eiseigaku Zasshi (J. Food Hyg. Soc. Japan), 14:542-8
(1973)
Tesoriero, A.A., Roxon, J.J.
H Cyclamate Metabolism; Incorporation of 5S into Proteins of
Intestinal Bacteria In Vitro and Production of Volatile
5S-containing Compounds.
Xenobiotica, 5(1):25-31 (Jan. 1975)
Testa, B.; Jenner, P.
H The Concept of Regioselectivity in Drug Metabolism.
J. Pharm. Pharmacol., 28(10):731-44 (1976)
40
-------
Thompson, G.R.
H Testicular Effects Produced by Cyclamate and Cyclohexylamina - A
Review.
Proceedings: 60th Annual Meeting of the Federation of American
Societies for Experimental Biology. Anaheim, CA, Apr. 11-16,
1976.
Fed. Proc., (Mar. 1976)
Thompson, G.R.; Mason, P.L.
H Testicular Effects of Cyclohexylamine Hydrochloride in the Rat.
Toxicology, 8(2):143 (Oct. 1977)
Thompson, G.R.; Sanders, P.G.
H Testicular Effects Produced by Cyclamate and Cyclohexylamine. A
Review.
Fed. Proc., 35(3):727 (1976)
Thompson, G.R.; Becker, B.A.; Levin, S.
H Assessment of the Carcinogenicity of Non-Nutritive Sweeteners.
Part 2. Cyclamates and Cyclohexylamine.
Proc. West Pharmacol. Soc., 18:311-8 (1975)
Tillberg, J.E.; Giersch, C.; Heber, U.
E C02 Reduction by Intact Chloroplasts under & Diminished Proton
Gradient.
Biochim. Biophys. Acta, 461-(l):31-47 (Jul. 7, 1977)
Tokieda, T.; Niimura, T.; Yamaha, T.; et al.
H Anaerobic Deamination of Cyclohexylamine by Intestinal
Microorganism in Rabbits.
Agric. Biol. Chem., 43(1):25-32 (Jan. 1979)
Tonomura, A.; Sasaki, M.; Yamada, K.
H Effect of Cyclohexylamine on Chromosomes.
Senshokutai, 2571 (Mar. 1969) (Jpn)
Kromosoma(Tokyo), 2571:79-80 (1970)
Torbin, V.F..
H Biological Effect of Oil Soluble Salt of Cyclohexylamine - An
Inhibitor of Atmospheric Corrosion of Metals.
Vrach. Delo. (U.S.S.R.), (8):121-4 (1976) (Rus)
Torbin, V.F.
H Comparative Characteristics of the Embryotoxic Action of Some
Polymethylene (Alicyclic) Series Amines.
Gig. Sanit., (7):100-2 (1976) (Rus)
Torbin, V.F.
E Hygienic Characteristics of Labor Conditions in Work with a
Water-Soluble Cyclohexylamine Salt.
Gig. Tr. Resp. Mezhved. Sb., (12):46-8 (1976) (Rus)
41
-------
Tremolieres, J.; Lowy, R.
H New Aspect of Toxicological Evaluation; Metabolic Toxicology of
Colza Oil and Wine.
Aliment. Vie, 60(3):207-15 (1972)
Tsel'm, N.K.; Yablonskaya, A.M.
E Solvent Selection of Extractive Purification of Waste Waters
from Caprolactam Production. II. Extraction of Amines.
Sb. Nauchn, TT., Kuzbasskii Politekeh. Inst. 1971, (36):19-24
(1972) (Rus)
Tsyrkunov, L.P.
H Skin Diseases in Workers Coming in Contact with Inhibitors of
the Atmospheric Corrosion of Metals.
Vestn. Dermatol. Venerol., (3):62-5 (1975) (Rus)
Turner, J.H.; Hutchinson, D.L.
H Cyclohexylamine Mutagenicityt An In Vivo Evaluation Utilizing
Fetal Lambs.
Mutat. Res., 26(5):407-12 (Oct. 1974)
United Nations. Food and Agriculture Organization/World Health
Organization
H Toxicological Evaluation of Some Flavouring Substances and
Non-Nutritive Sweetening Agents.
FAO Nutr. Meet. Rep. Ser. 44A, WHO/Food Add./68, 33 (1968)
United Nations. Food and Agriculture Organization, Joint
FAO/WHO Expert Committee on Food Additives
H Evaluation of Food Additives. Fourteenth Report.
FAO Nutrition Meetings Report Series, No. 48:36pp. (1970)
WHO Tech. Rep. Ser. 462, 1971
United Nations. Food and Agriculture Organization/World Health
Organization
H Toxicological Evaluation of Some Extraction Solvents and Certain
Other Substances.
FAO Nutrition Meetings Report Series, 48A; WHO/Food Add./70,39
:131pp. (1971)
United Nations. World Health Organization. International
Agency for Research on Cancer
H IARC Monographs on the Evaluation of the Carcinogenic Risk of
Chemicals to Humans; Some Non-Nutritive Sweetening Agents.
IARC Monogr. Eval. Carcinog. Risk Chem., 22:64-109 (1980)
United States. Department of Health, Education and Welfare.
Public Health Service. Center for Disease Control. National
Institute for Occupational Safety and Health
H Information Profiles on Potential Occupational Hazards. Volume
I. Single Chemicals. Cyclohexylamine.
U.S. NTIS PB-81-148017
42
-------
United States. National Academy of Sciences. National Research
Council
H The Safety of Artificial Sweeteners for Use in Food.
National Research Council Publ., 386 (1955)
United States. National Academy of Sciences. National Research
Council. Food Protection Committee. Ad HOC Committee on
Non-Nutritive Sweeteners
H Non-Nutritive Sweeteners. An Interim Report to the U.S. Food
and Drug Administration, Department of Health, Education, and
Welfare.
NAS (NRC) Report, p. 50a (Nov. 1968)
United States. National Academy of Sciences. National Research
Council
H Report on Non-Nutritive Sweeteners.
Food Protection Committee (Oct. 16, 1969)
Valfencia-Parparcen, J.
H Tubeleas Hypotonic Duodenography.
GEN., 27(2):157-83 (1972)
Van Went-De Vries, G.F.; Freudenthal, J.; Hogendoorn, A.M.; et
al.
H In Vivo Chromosome-damaging Effect of Cyclohexylamine in the
Chinese Hamster.
Food Cosmet. Toxicol., 13(4):415-8 (Aug. 1975)
Van Went-De Vries, G.F.; Kragten, M.C.T.; Van den Bosch, R.A.
H Lack of Effect of Blood Sampling-induced Hematopoiesis on In
Vivo Chromosome Damage by Cyclohexylamine in Chinese Hamsters.
£C
):
Food Cosmet. Toxicol., 13(4):419-21 (Aug. 1975)
Vershuuren, H.G.
H Carcinogenicity Tests of Cyclamate, Cyclohexylamine, and
Saccharin in Mice.
Proceedings: International en Symposion ueber Substoffe.
Hunnover, Arztekammer Niedersachsen. Nov. 6, 1973.
Verschuuren, H.G.; Van Esch, G.J.; De Vries, Th.; et al.
H Long-Term Toxicity and Reproduction Study (Including a
Teratogenicity Study) with Cyclamate, Saccharin, and
Cyclohexylamine.
Toxicology, 8(3):285 (Dec. 1977)
Vogel, E.
H The Relation between Mutational Pattern and Concentration by
Chemical Mutagens in Drosophila.
IARC Sci. Publ., 12:117-37 (1976)
43
-------
Vogel, E., Chandler, J.L.R.
H Mutagenicity Testing of Cyclamate and Some Pesticides in
Drosophila melanogaster.
Experientia (Switzerland), 30(6):621-3 (1974)
Vogin, E.E.; Cox, G.E.; Carson, S.; et al.
H Long-Term and Multigeneration Toxicity Studies with
Cyclohexylamine Hydrochloride.
Toxicology, 6(1):47 (Jun. 1976)
Voloshina, E.I.
E Determination of the Oil-Soluble Salt of Cyclohexylamine
(Inhibitor M-l) and Cyclohexylamine Metanitrobenzoate (inhibitor
Ts-2) in the Air by a Thin-Layer Chromatographic Method.
Gig. Sanit., (8):72-4 (1978) (Rus)
Wallace, J.; Alarie, Y.
H The Interactions of Sensory Irritants with a
Glutathione-S-Transferase Activity from Bovine Corneal
Epithelium.
Toxicol. Appl. Pharmacol., 45(1):358 (1978)
Wallace, W.C.; Lethco, E.J.; Brouwer, E.A.
H Metabolism of Cyclamates in Rats.
J. Pharmacol. Exp. Ther., 175(2):325-30 (1970)
Watrous, R.M.; Schulz, H.N.
H Cyclohexylamine, p-Chlornitrobenzene, 2-Aminopyridine; Toxic
Effects in Industrial Use.
Symposium: Joint Meeting of the American Industrial Hygiene
Association and the American Association of Industrial
Physicians and Surgeons. Apr. 25, 1950.
Ind. Med. Surg., 19(7):317-20 (Jul. 1950)
Wechsler, A.S.; Epstein, S.E.; Click, G.
H Mechanism of the Sympathomimetic Action of Cyclohexylamine and
Hexylamine Release of Catecholamines from Nerve Endings.
J. Pharmacol. Exp. Ther., 170(1):62-71 (Nov. 1969)
Weston, R.E.; Wheals, B.B.
E The Determination of Cyclohexylamine by Electron-Capture Gas
Chromatography.
Analyst, 95(132):680-2 (Jul. 1970)
Williams, R.T.
H The Metabolism of Certain Drugs and Food Chemicals in Man.
Ann. N.Y. Acad. Sci., 179:141-54 (1971)
Williams, R.T.
H Inter-Species Variations in the Metabolism of Xenobiotics.
Biochem. Soc. Trans., 2(3):359-77 (1974)
44
-------
Wills, J.H.; Jameson, E.; Stoewsand, G.; et al.
H A 3-Month Study of Daily Intake of Sodium Cyclamate by Man.
Toxicol. Appl. Pharmacol., 12(2):292 (1968)
Wilson, J.G.
H Abnormalities of Intraueterine Development in Non-Human Primates.
Acta Endocrinol. (Suppl.), 166:261-92 (1972)
Wilson J.G.
H Use of Primates in Teratological Investigations.
Conference: Medical Primatology; Selected Papers on Exp. Med.
Surg. Primates, 3:286-95 (1972)
Wolf, A.; Hrivnak, D.; Malkus, Z.
H Safety of Cyclamate.
Nahrung, 15(4):363-6 (1971) (Ger)
Yamamura, H.I.; Dixon, R.L.
H The Sympathomimetic Action of Cyclohexylamine - A Metabolite of
Cyclamate.
Toxicol. Appl. Pharmacol., 12(2):289-90 (1968)
Yamamura, H.I.; Lee, I.P.; Dixon, R.L.
H Study of Sympathomimetic Action of Cyclohexylamine, a Possible
Metabolite of Cyclamate.
J. Pharmacol., 57(7):1132-4 (Jul. 1968)
45
-------
APPENDICES
-------
Appendix I
Abstract Collections Manually Searched
Source Period of Coverage
Chemical Abstracts* (1930-1976)
Biological Abstracts* (1930-1970)
Excerpta Medica*
Physiology, Biochemistry, Pharmacology, (1965-1974)
Toxicology
Cancer (1953-1974)
Public Health, Social Medicine, Hygiene (1955-1974)
Clinical Biochemistry (1969-1974)
Pharmacology and Toxicology (1969-1974)
Occupational Health (1972-1975)
Current Contents
Life Sciences (Oct. 1979-Mar. 1980)
(Apr. 1981-May 1981)
Physical Sciences (Oct. 1979-Mar. 1980)
(Apr. 1981-May 1981)
Agriculture (Oct. 1979-Mar. 1980)
(Apr. 1981-May 1981)
Industrial Hygiene Digest (1943-1979)
Index Medicus* (1930-1976)
Toxicology Research Projects Directory (Oct. 1979-Mar. 1980)
*Recent issues searched on-line.
-------
File
Appendix II
On-Line Databases Searched
National Library of Medicine (MEDLARS)
Coverage Period of File
+ indicates that the database is continually updated.
Chemline
Toxline
Toxback 65
Toxback 74
Cancerlit
Cancerproj
Medline
Back 66
Back 69
Back 72
Back 75
Back 77
SDILINE
Toxicology Data Bank
RTECS
Strategy
Cyclohexanamine
Cyclohexylamines
Cyclohexylamine
Aminocyclohexane
Aminohexahydrobenzene
Hexahydroaniline
Hexahydrobenzenamine
N/A
1978+
1965-1973
1974-1978
Jan. 1963+
1976-1978
Jan. 1979+
Jan. 1966-Dec. 1968
Jan. 1969-Dec. 1971
Jan. 1972-Dec. 1974
Jan. 1975-Dec. 1976
Jan. 1977-Dec. 1978
Present Month's Update
N/A
1978 Edition
Search Strategy
(RN) 4998-76-9*
(RN) 26593-77-1*
(RN) 6941-45-3*
(RN) 24407-06-5*
(RN) 16545-55-4*
(RN) 15830-14-5*
(RN) 27817-50-1*
*CAS registry numbers searched in appropriate files
-------
Appendix II
On-Line Databases Searched (cont'd)
National Library of Medicine (MEDLARS)
Search Strategy Search Strategy
(RN) 108-91-8* (RN) 19834-02-7*
(RN) 26227-54-3*
*CAS registry numbers searched in appropriate files
All search statements were combined with the logical operator "or" before
printout.
-------
Appendix II
On-Line Databases Searched (cont'd)
Department of Energy (RECON)
File Coverage Period of File
+ indicates that the database is continually updated.
Water Resources Abstracts 1968+
Environmental Mutagen Information Center 1969+
Environmental Teratogen Information Center 1975+
Search Strategy
IT = Cyclohexylamine
RN = 108-91-8
Chemical Information System*
Structure and Nomenclature Search System (SANSS)
(RN) 108-91-8
*Searched to obtain synonyms only
National Institute for Occupational Safety and Health
NIOSHTIC 1973+
+ indicates that the database is continually updated.
Search Strategy
Cyclohexylamine
108-91-8
-------
Appendix II
On-Line Databases Searched (cont'd)
Lockheed Information Systems (DIALOG)
File
Coverage Period of File
+ indicates that the database is continually updated
Agricola
Air Pollution Technical Information Center
Aquatic Sciences and Fisheries Abstracts
Biosis Previews
Chemical Abstracts Search
CA Patent Concordance
Commonwealth Agriculture Bureaux Abstracts
Chemical Industry Notes
C hem name
Claims/Chem
Comprehensive Dissertation Abstracts
Conference Papers Index
Current Research Information System
EIS Industrial Plants
Enviroline
Environmental Periodicals Bibliography
Excerpta Medica
Food Science & Technology Abstracts
GPO Monthly Catalog
Ins pec
National Technical Information Service
Oceanic Abstracts
Pharmaceutical News Index
Pollution Abstracts
PTS Funk and Scott Indexes
PTS Federal Index
PTS Promt
SciSearch
Smithsonian Science Information Exchange
Current Research Information System
Compendex
Inspec
Metadex
Pira
Aug. 1971+
1966-Oct. 1978
Jan. 1975+
1969+
1970+
Jan. 1972+
Jan. 1973+
1974+
N/A
1950-1970
1861+
1973+
Jul. 1974+
N/A
1971+
1973+
Jun. 1974+
1969+
Jul. 1973+
1969+
1974+
1964+
Dec. 1975+
1970+
1972+
Oct. 1976+
1972+
Jan. 1974+
Most Recent 2 Yrs,
Jul. 1974+
1970+
1969+
1966+
1975+
-------
Appendix II
On-Line Databases Searched (cont'd)
Lockheed Information Systems (DIALOG)
Search Strategy
eyelohexanamine
cyclo(W)hexanamine
cyclo(W)hexan(W)amine
cyc1ohexy1amine
cyclo(W)hexylamine
cyclo(W)hexyl(w)amine
aminocyclohexane
ami no(W)cyclohexane
amino(W)cyclo(W)hexane
aminocyclo(W)hexane
aminohexahydrobenzene
amino(W)hexahydrobenzene
amino(W)hexa(W)hydrobenzene
amino(W)hexa(W)hydro(W)benzene
aminohexa(W)hydrobenzene
aminohexa(W)hydro(W)benz ene
aminohexahydro(W)benzene
hex ahydr oan ili ne
hexa(W)hydroaniline
Search Stragety
hexa(W)hydro(W)aniline
hexahydro(W)aniline
hexahydrobenzenamine
hexa(W)hydro(W)benzenamine
hexa(W)hydrobenzenamine
hexa(W)hydro(W)benzen(W)amine
hexa(W)hydrobenzen(W)amine
hexahydro(W)benzene(W)amine
hexahydro(W)benzenamine
108-91-8*
26227-54-3*
4998-76-9*
26593-77-1*
6941-45-3*
24407-06-5*
16545-55-4*
15830-14-5*
27817-50-1*
19834-02-7*
* CAS Registry Numbers used in appropriate files
-------
Appendix II
On-Line Databases Searched (cont'd)
Systems Development Corporation (ORBIT)
Database Coverage Period of File
+ indicates that the database is continually updated.
Apilit 1974+
Apipat 1964+
Chemdex 1972+
Crecord 1976+
Fedreg Mar. 1977+
Libcon 1968+
Paperchem 1968+
P/E News 1975
Safety Science Jun. 1975+
Titus 1970+
World Patent Index 1963+
Search Strategy Search Strategy
cyclohexanamine 4998-76-9*
cyclohexylamine 26593-77-1*
aminocyclohexane 6941-45-3*
aminohexahydrobenzene 24407-06-5*
hexahydroaniline 16545-55-4*
hexahydrobenzenamine 15830-14-5*
108-91-8* 27817-50-1*
26227-54-3* 19834-02-7*
*CAS registry numbers searched in appropriate files
All search statements were combined with the logical operator "or" before
printout.
------- |