United States
Environmental Protection
Agency
Office of
Pesticides and Toxic Substances
Washington DC 20460
June 1985
Pesticides
Guidance for the
Reregistration of
Pesticide Products
Containing Metribuzin
-------
GUIDANCE FOR THE REREGISTRATION
OF PESTICIDE PRODUCTS
CONTAINING METRIBUZIN
AS THE ACTIVE INGREDIENT
EPA CASE NUMBER 181
U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20460
June 1985
-------
TABLE OF CONTENTS
Introduction 1
I. Regulatory Position and Rationale 4
II. Requirement for Submission of Generic Data 51
III. Requirement for Submission of Product-Specific
Data 55
IV. Submission of Revised Labeling 91
A. Label Contents 91
B. Collateral Information 97
V. Instructions for Submission 93
-------
APPENDICES
Page
II-l Guide to Bibliography ................ 102
II-2 Bibliography ..................... 104
II-3 PIPRA §3(c)(2)(B) Summary Sheet - EPA Form 8580-1 . .
II-4 Certification of Attempt to Enter Into an Agreement
with Other Registrants for Development of Data
EPA Form 8580-2 ................... 124
III-l Product Specific Data Report (End-Use Products) . . 125
IV-1 40 CPR 162.10 Labeling Requirements ........ 127
IV-2 Table of Labeling Requirements ........... -jo^
IV- 3 Physical/Chemical Hazards Labeling Statement. . . . 130
IV-4 Storage and Disposal Instructions .........
ii
-------
INTRODUCTION
The Federal Insecticide, Fungicide, and Rodenticide Act
(FIFRA sec. 3(g)) directs EPA to reregister all pesticides as
expeditiously as possible.
To carry out this task, EPA has established the Regis-
tration Standards program, which will review all pesticide
products containing active ingredients first registered before
January 1, 1977. Pesticides will be reviewed in use clusters
which have been ranked to give earliest review to pesticides
used on food and feed crops.
The Registration Standards program involves a thorough
review of the scientific data base underlying pesticide
registrations and an identification of essential but missing
studies which may not have been required when the product
was initially registered or studies that are now considered
insufficient. EPA's reassessment results in the development
of a regulatory position, contained in a Registration Standard,
on each pesticide and its uses. The Agency may require the
registrant to modify product labels to provide additional
precautionary statements, restrict the use of the pesticide
to certified applicators, provide reentry intervals, modify
uses or formulation types, specify certain packaging limitations,
or other requirements to assure that proper use of the pesticide
will not result in adverse effects on the environment.
The scientific review, which is not contained in this
Guidance Package but is available upon request, concentrates
on the technical grade of the active ingredient and identifies
missing generic data. However, during the review of these
data we are also looking for potential hazards that may be
associated with the end use (formulated) products that contain
the active ingredient. If we have serious concerns, we will
address end use products as part of the Registration Standards
program and will propose regulatory actions to the extent neces-
sary to protect the public.
EPA has the authority under FIFRA sec. 3(c)(2)(B) to
require registrants to submit data that will answer our
questions regarding the hazard that may result from the
intended use of a pesticide. Although sec. 3(c)(2)(B) provides
that all registrants are responsible for these data, the
Agency generally imposes generic data requirements only on the
registrants of the manufacturing use products (basic suppliers
-------
of the active ingredient) and other producers who do not
qualify for the formulator's exemption.*
A producer who wishes to qualify for the formulator's
exemption may change his source of supply to a registered
source, provided the source does not share ownership in
common with the registrant's firm. A registrant may do so
by submitting a new Confidential Statement of Formula, EPA
Form 8570-4, identifying the registered source of the active
ingredient, to the appropriate Product Manager within 90
days of receipt of this Guidance Document. The chart on the
following page shows what is generally required of those who
do and do not qualify for the formulator*'s exemption In the
Registration Standards program.
If you decide to request the Agency to cancel the regis-
tration of any of your products subject to the requirements
of this Guidance Document, please notify the Product Manager
named in the cover letter, within 90 days from the receipt
of this document. If you decide to maintain your product
registrations), you must provide the Information described in
the following pages within the timeframes outlined. EPA will
issue a notice of intent to cancel or suspend the registration
of any currently registered product which does not comply
with the requirements set forth in this Guidance Document.
You are reminded that FIFRA sec. 6(a)(2) requires you to
submit factual information raising concerns of possible
unreasonable adverse effects of a pesticide. You should
notify the Agency of interim results of studies in progress
if those results show possible adverse effects.
•The formulator's exemption applies to a registrant of an
product if the source of his active ingredient(s): (1) is a
registered product and (2) is purchased from a source which
does not have ownership in common with the registrant's
firm.
-------
PRODUCTS SUBJECT TO THE
REGISTRATION STANDARDS PROGRAM
ACTION(S) REQUIRED TO
MAINTAIN REGISTRATION
I. Products That Do Not Qualify
For The Formulator's Exemption
A. Single Active Ingredient
Products*
These products must be reregis-
tered. To obtain reregistration,
labeling, packaging and data
requirements must be satisfied
in accordance with the Regis-
tration Standards Guidance
Document.
B. Multiple Active Ingredient
Products
These products will not be
reregistered at this time.
However, generic data required
to continue the registration of
the active ingredient under
review, as described in the
Registration Standards Guidance
Document, will be required and
some labeling precautions may
also be required.
II. Products That Do Qualify For
The Formulator's Exemption
Only when additional restric-
tions or labeling are needed to
protect man or the environment
will these products be subject
to the Registration Standard
requirements. Affected products
will be dealt with in a variety
of ways, including but not
limited to the Label Improvement
Program and special intent
to cancel notices.
* End use products of registrants who also produce a manufacturing
use product will not be required to be reregistered provided that
registrant fulfills the requirements specified in the Guidance
Document for manufacturing use product(s). Such end use products
will be subject to the labeling changes required for products in "II"
above. If there are no manufacturing use products registered by any
company end use products will be required to be reregistered.
NOTE: If all registrants in "I" above fall to meet the requirements in
I-A and B above, then the registrants in "II" lose their right to
qualify for the formulator's exemption and become subject to the
requirements In I-A and B.
-------
II. REGULATORY POSITION AND RATIONALE
A. INTRODUCTION
This Registration Standard describes the regulatory position and
rationale of the Environmental Protection Agency ("The Agency")
for all registered manufacturing-use products (MP's) and end-use
products (EP's) containing metribuzin as the sole active ingredient.
The Agency bases its position and rationale on an evaluation of
all MP's, and PIPRA sections 3 and 24(c) and intrastate uses
registered for metribuzin. EP's are reviewed only when there
are no MP's registered or when the label has been changed signi-
ficantly from the current accepted label. Mixtures are included
only when there is a significant change in the label. After
briefly describing the chemical and its uses, this chapter presents
the Agency's regulatory position and rationale, the criteria for
registration, acceptable ranges and limits, labeling requirements,
and the tolerance reassessments.
B. DESCRIPTION OP CHEMICAL
Metribuzin Is the acceptable common name for the compound:
4-amino-6-(l,l-dimethylethyl)-3-(methylthio)-l,2,4-triazin-5(4H)
one as determined by the British Standards Institution, International
Organization for Standardization, and Weed Science Society of
America. Other names include Lexone, Sencor, Sencoral, Sencorex,
4-amino-6-tert-butyl-3-(methylthio)-l,2,4-triazin-5(4H)-one,
4-amino-6-tert-butyl-4,5-dihydro-3-methythio-l, 2,4-triazin-5-one,
4-amino-6-tert-butyl-3-(methylthio)-triazin-5(4H)-one, metribuzin,
Bayer 94337, Bayer 6159H, Bayer 6443H, and DIG 1468. The Chemical
Abstracts Service (CAS) Registery number is 21087-64-9. The
Office of Pesticide Program's EPA Chemical Code Number is 101101.
Metribuzin is a white crystalline solid at room temperature and
has a sulfurous odor. The empirical formula is CgHiijNijOS, and
its molecular weight is 214.28. The melting point is 125.5-
126-5 °C. Metribuzin is soluble in aromatic and chlorinated
hydrocarbon solvents, and in water (at 20 °C) to 1220 ppm.
Metribuzin is a triazine herbicide which selectively controls
certain broadleaf weeds and grassy weed species on field crops,
vegetable crops, bermuda grass (turf) and noncrop areas. Metribuzin
may be soil incorporated, surface applied or applied foliarly,
broadcast or banded using ground equipment. It can be applied by
aerial equipment or sprinkler irrigation (potatoes). Of the
total amount of metribuzin used in the United States 94 percent
is on soybeans, /v 1.8 percent on potatoes, /^ 1.5 percent on
wheat, and ^1.2 percent on sugarcane.
-------
Metribuzin is a systemic herbicide which is absorbed by the
root system and then travels through the plant causing chlorosis,
growth inhibition and necrosis. Metribuzin is a photosynthetic
inhibitor. Metribuzin was first registered for use in 1973•
Technical metribuzin is produced in the United States by Mobay
Chemical Corporation of Kansas City, Missouri.
Metribuzin is available as a 50 percent formulation intermediate
(PI) and 94 percent technical for formulation of metribuzin
end-use products. Metribuzin is available as a wettable powder
(WP), flowable concentrate (PIC), and dry flowable (DP) formulations,
C. REGULATORY POSITION AND RATIONALE
Based on the review and evaluation of all available data and
other relevant information on metribuzin, the Agency has made the
following determinations:
1. The available data do not indicate that any of the risk
criteria listed in l62.11(a) of Title 40 of the U.S. Code of
Federal Regulations have been met or exceeded for the uses of
metribuzin at the present time.
Rationale: Only minor or no discernible toxicity by the oral,
dermal, inhalation and ocular routes of exposure was observed.
The 2-year dog study satisfied the requirement for a chronic
and subchronic dog study. This study indicated that dogs dosed
with 1500 ppm (37-5 mg/kg) had reduced weight gain, increased
mortality, hematological changes and liver and kidney damage.
These observations were not seen at lower dosages, and the
Acceptable Daily Intake (ADI) was based on the NOEL of 100 ppm
(2.5 mg/kg) as shown in section G. The oncogenic potential of
metribuzin is unclear at this time. Although the chronic mouse
study study is negative for oncogenic effects, the chronic rat
study (currently classified as "supplementary data") indicates
a statistically significant (p < 0.05) increase in the incidence
of adenoma of the liver bile duct and pituitary gland in females
at the 300 ppm dose level. However, only a small number of
animals were examined histopathologically from other dose
levels and at this point it is not clear whether the apparent
increase is related to compound administration. Additional
data must be supplied in the form of histopathological
examinations in the animals not previously examined in the other
three dosage groups along with historical control data on the
on the incidence of these tumors in this particular rat strain.
Exact nomenclature (terminology used) used for neoplastic and
non-neoplastic findings, specifically live bile duct adenoma,
"changes in nucleus" in the liver and "tumor" must be defined.
A teratology study in rabbits indicated no evidence of teratogenic
effects at 135 mg/kg/day, the highest dose tested (HOT) and a
NOEL of 15 mg/kg/day for maternal and fetal toxicity. The
available data indicate no mutagenic effects.
-------
In addition to a repeat of the rat chronic study, other data gaps
include rat teratology, multigeneration reproduction study, two
categories of mutagenicity testing, specifically gene mutatuion
testing, studies in mammalian cells and tests for primary DNA
damage such as sister chromatid exchange or unscheduled DNA
synthesis assay.
2. Products which are substantially similar to the registered
products may be considered for registration subject to the
terms and conditions of this document. However, the Agency
will not allow any significant new uses* to be established
for metribuzin until the toxicology and residue chemistry
data deficiencies identified in Table A have been satisfied.
Rationale: The Agency does not think new registrations of uses
already on the market will increase the risks to the public
from exposure to metribuzin because the total amount of product
used will not increase. The Agency is unable to complete
a tolerance reassessment of metribuzin because of extensive
residue chemistry data gaps including additional metabolism
data in plants, poultry, ruminants and additional data on crop
and processed commodities. Toxicology data gaps include rat
chronic, rat teratology and a multigeneration reproduction
study. If additional metabolites of toxicological concern are
found in the requested metabolism studies, the tolerance
expression will have to be changed to include the additional
metabolite(s) of concern.
3. The Agency will require MP's containing metribuzin to bear
Category III hazard statements and other warning statements
as required in the precautionary labeling under 40 CPR 162.10.
Rationale: Acute toxicity studies for metribuzin showed the
following: Toxicity Category III for oral toxicity and Toxicity
Category IV for acute inhalation and for dermal and' primary
eye irritation.
4. The Agency is requesting information on presence of N-nitroso
contaminants in the 94 percent T and 50 percent PI, but is
not taking action at this time.
Rationale: Compounds of similar structure including, cyanazine,
atrazine, simazine, pendimethalin, and parathion have been
shown to contain N-nitroso contaminants. Available data,
although incomplete, do not provide grounds for concern at
this time. Action is reserved pending submission and review
of the requested data.
* "Significant New Use" is defined in 44 PR 27934, May 11, 1979.
In case of new food or feed use, the Agency will consider as
significant an increase in the Theoretical Maximum Residue
Contribution of greater than 1 percent.
-------
5. The Agency Is requiring acute testing of metribuzin on a
marlne/estuarine fish species and an oyster species, and an
acute dietary study on an upland gameblrd species. No
additional precautionary labeling or field testing Is being
required at this time. For the present, the Agency is re-
quiring HP's and EP's containing raetribuzin to bear revised
environmental hazard statements (Refer to Section P, REQUIRED
LABELING).
Rationale: Ecological effects studies indicate that available data
on metribuzin are adequate to fulfill regulatory requirements
in most areas and that metribuzin was moderately toxic to
upland bird species on an acute oral basis, no more than slightly
toxic to birds in the diet, moderately toxic to Daphnia magna
and slightly toxic to freshwater fish. Marine/estuarlne species
may be exposed to metribuzin used on sugarcane and soybeans.
Available data indicate that metribuzin is slightly toxic to
shrimp. ' Data on acute toxicity to a marine/estuarine fish
species and'an oyster species are needed. Directions for some
use patterns indicate that applications can be repeated.
Available Information indicates that metribuzin is very persistent
in the soil. Multiple treatments could Increase dietary risk
and a long soil half-life may indicate a significant chronic
exposure. Environmental fate information ils; needed to determine
the potential for chronic exposure. A detailed ecological
hazard assessment cannot be made until the acute dietary study
on an upland gameblrd, acute toxicity studies on a marine/
estuarlne fish species and an oyster species, and appropriate
environmental fate data are submitted. All other testing Is
reserved pending submission and review of these data.
6. The Agency is requiring a statement on the label concerning
endangered plants on all EP's for use of metribuzin on non-
cropland (specifically, rights-of-way). Refer to Section P,
REQUIRED LABELING.
Rationale: Consultation with Office of Endangered Species (OES)
on another chemical, sulfometuron methyl (Oust Herbicide) indicates
that several species of endangered plants including Brady
pincushion cactus (Pediocactus bradyl), Mesa Verde cactus
(Sclerocactus mesae-verdae), Peebles Navajo cactus (Pediocactus
(Sclerocactus wrlj
peeblesianus var. peeblesianus), Wright fishhook cactus
Lghtiae), Kuenzler hedgehog cactus (Echlnocereus
kuenzlerl), Lloyd's hedgehog cactus (Echlnocereus lloydli),
Sneed pincushion cactus (Coryphantha sneedll var. sneedil),
Chapman rhododendron (Rhododendron chapmanil), Rydbergy milk-
vetch (Astragalus perianus), Harper's beauty (Harperocallis
flava), dwarf bear-poppy (Arctomecon humills), MacParlane's
four-o'clock (Mlrabllis macfarlanle), northern wild monkshood
-------
(Aconltum npveboracense), gypsum wild buckwheat (Erlogonum
gypsophilum), Texas poppy-mallow (Gallirhoe scabriuscula),
hairy rattleweed (Baptlsla arachnifera), Malheur wire-lettuce
(Stephanomeria malheurensls), phacelia (Phacelia argillacea),
bunched arrowhead (Saglttaria fasciculata), San Diego mesa mint
(Pogogyne abramsii), Solano grass (Orcuttia mucronata), salt
marsh bird's beak (Cordylanthus marltimus ssp. maritimus),
Uinta Basin hookless cactus (Sclerocactus glaucus), Contra
Costa wallflower (Erysimum capitatum var. angustatum), and
Antioch Dunes evening-primrose (Oenothera deltoides ssp.
howelll), which occur on or adjacent to rights-of-way may be
potentially exposed to metribuzin, when used in rights-of-way,
and this exposure would cause mortality to contacted plants.
Because of the limited population size of many of these species
a local spraying program could virtually destroy the entire
species. Exposure to metribuzin is likely to result in the
destruction or adverse modification of the critical habitat of
gypsum wild buckwheat, Malheur wire-lettuce, Contra Costa
wallflower, and Antioch Dunes evening-primrose.
7. The Agency is imposing restrictions on rotational crops.
The extent of these restrictions will be reconsidered when
additional data are received (Refer to Section P, REQUIRED
LABELING).
Rationale: It is the policy of the Agency to impose restrictions
on planting rotational crops when data are insufficient to allow
an assessment of the Impact of planting subsequent crops.
This serves to protect the public from impermissable residues
in food and feed and to protect subsequent planted crops from
adverse effects due to persisent residues.
8. The Agency will require ground water monitoring studies for
metribuzin. The registrants will be notified of types of
studies required and sites to be tested (the Agency is in the
process of determining the types of studies and sites to be
tested), by means of an amendment to the Standard three months
after Issuance of the Standard. The Agency is requireing that a
ground water advisory appear on the label of all EP's (Refer
to Section P, REVISIED LABELING).
Rationale: Metribuzin was detected in the low parts-per-blllion
range in Ohio rivers and Iowa wells. Although there are
several data gaps in the area of environmental fate, the available
data indicate metribuzin has a potential to contaminate ground
water in soils lower in organic matter and clay content. Both
the soil absorption and column studies reviewed indicate that
metribuzin has considerable potential to leach in a number of
soil types. Metribuzin dissipates in the field with half-lives
of < 1 to about 6 months. Data gaps in the area of environmental
8
-------
fate include hydrolysis, photodegradation, aerobic and anaerobic
soil metabolism, leaching, absorption/desorption studies, field
dissipation and accumulation studies in crops and fish.
However, hydrolysis, photodegradation in water and on soil,
aerobic and anaerobic soil metabolism, mobility and field
dissipation were requested on July 25, 1984 for ground water
contamination assessment through the Data Call-in process. The
data were received on November 1984. These studies have been
screened and support the Agency's concern over the potential
for ground water contamination and the need for the ground
water monitoring.
9. The Agency has determined that all uses of metribuzin should
be classified for "RESTRICTED USE" with appropriate labeling
(Refer to Section P, REQUIRED LABELING and SECTION IV of
the Guidance Document).
Rationale: Metribuzin has been detected in the low parts per
billion range in Ohio rivers and Iowa wells. The chronic rat
study indicates a significant (p<0.05) increase in the incidence
of adenoma of the liver bile duct and pituitary gland in
females of the 300 ppm dose level. In addition to a repeat of
this study data gaps include rat teratology, multigeneration
rat reproduction study and mutagenicity testing.
10. The Agency is not requiring a re-entry interval for currently
registered uses of metribuzin at this time.
Rationale: Metribuzin has low acute toxicity (Category III) for
oral and Category IV for all other forms of acute toxicity.
D. CRITERIA FOR REGISTRATION UNDER THIS DOCUMENT
To be subject to this guidance document, MP's must meet the
following conditions:
1. Contain metribuzin as the sole active ingredient and,
2. Conform to the acute toxicity limits, production composition,
and use pattern requirements listed in Section P of this
document.
Registration of products subject to this document must comply
with all terms and conditions described in it, including commitment
to fill data gaps on a schedule acceptable to EPA and consistent
with that required of the present registrant. All registrants and
applicants for registration under this document must follow the
instructions contained in this document and complete and submit
the appropriate forms within the specified time.
-------
E. ACCEPTABLE RANGES AND LIMITS
1. Product Composition Standard
Technical grade products must contain at least 9^.0 percent
metribuzin as the sole active Ingredient. HP's must contain
50 percent metribuzin as the sole active ingredient. Each MP
formulation proposed for registration must be fully described
active ingredient found in HP's must be substantially similar to
that in currently registered technical products or manufacturing-
use products. An MP not meeting these requirements will be
considered a new product and will not be registerable under this
guidance document.
2. Acute Toxlcity Limits
The Agency will reconsider registrations of products containing
metribuzin, provided that the product labeling bears appropriate
precautionary statements for the acute toxlcity category in which
each product is placed.
3. Use Patterns
To be registered under this standard, MP's containing metribuzin
must be labeled for formulation only Into end-use herbicide
products for commodities listed below. The attached index entry
lists all registered uses, as well as approved maximum application
rates and frequencies of application.
Metribuzin, a selective herbicide is registered for control of
broadleaf and grassy weed species on the following sites:
soybeans, potatoes, alfalfa, sainfoin, asparagus, barley, field
corn, sugarcane, tomatoes, wheat, turf (bermuda grass), peas,
lentils, and noncrop sites.
P. REQUIRED LABELING
All technical grade products, MPs and EPs containing metribuzin
must bear appropriate labeling as specified in 10 CPR Section
162.10. Other portions of this guidance package contain infor-
mation regarding label requirements.
In addition to the requirements stated in 40 CPR Section 162.10,
the following information must appear on the labeling of products
released for shipment after December 31, 1985, and on products in
the channels of trade after June 30, 1986.
10
-------
1. Ingredient Statement
The Ingredient statement for MPs must list the active
Ingredient as:
Metribuzin, 4-amino-6-(l,l-dimethylethyl)-3-
(methylthlo ) -1 , 2 , 4-triazin-5 ( 4H) one
2. Manufacturing-Use Product Statements
All products Intended for formulation into end-use
products must bear the following statement:
"Do not discharge effluent containing this product into
lakes, streams, ponds, estuaries, oceans or public
water unless this product is specifically Identified
and addressed in an NPDES* permit. Do not discharge
effluent containing this product to sewer systems with-
out previously notifying in writing the sewage treatment
plant authority. For guidance contact your State Water
Board or Regional Office of EPA."
» National Pollution Discharge Elimination System.
3. End-Use Products
Restricted Use
All products must be classified at "RESTRICTED USE" with
appropriate language (Refer to 40 CPR 160.10(J)(2)(B).
Ground Water Advisory
"Metribuzin is a chemical which can travel (seep or
leach) through soil and can contaminate ground water
which may be used as drinking water. Metribuzin has
been found In ground water as a result of agricultural
use. Users are advised not to apply metribuzin where
the water table (ground water) is close to the surface
and where the soils are very permeable, i.e., well
drained soils such as loamy sands. Your local agricul-
tural agencies can provide further information on the
type of soil in your area and the location of ground
water."
Outdoor Uses
"Do not apply directly to water or wetlands. Do not
contaminate water by cleaning of equipment or disposal
of waste."
11
-------
Endangered Species - Noncropland (Rlghts-of-Way)
Notice; The use(s) of this product on rlghts-of-way may
pose a hazard to certain Federally designated endangered
plant species. They are known to be found In specific
areas within the locations noted below. Prior to making
applications, the user of this product must determine
that no such species are located In or Immediately
adjacent to the area to be treated. For Information
on protected species contact the Endangered Species
Specialist of the appropriate Regional Office of the
U.S. Fish and Wildlife Service listed below:
Region 1-Portland, Oregon
California counties of Contra Costa, Solano,
San Diego, Santa Barbara, Ventura, Los Angeles and
Orange.
Idaho, Idaho county.
Oregon, Harney county.
Region 2-Albequerque, New Mexico
Arizona counties of Coconino and Navajo.
New Mexico counties of San Juan, Otero, Chaves,
Lincoln, Eddy and Dona Ana.
Texas counties of El Paso, Pecos and Runnels.
Region 3-Twin Cities, Minnesota
Iowa counties of Allamakee, Clayton, and Jackson.
Region 4-Atlanta, Georgia
Florida counties of Wayne and Brantley.
North Carolina, Henderson county.
South Carolina, Greenville county.
Region 5-Newton Corner, Massachusetts
New York, Ulster county.
Region 6-Denver, Colorado
Utah counties of Emery, Piute, Garfield, Washington,
Utah and Wayne.
Colorado counties of Montezuma, Delta and Montrose.
Restrictions on Rotational Crops
"Do not plant food or feed crops other than those which
are registered for use on metribuzin treated soils."
G. TOLERANCE REASSESSMENT
The Acceptable Daily Intake (ADI) for metribuzin was
originally based on a 2-year feeding study in rats. The
ADI was subsequently recalculated using a 2-year chronic
dog feeding study because it resulted in a lower no-observable
effect level (NOEL) of 100 parts per million (ppm).
12
-------
The 2-year chronic rat feeding study was rerevlewed and
classified as supplementary data for the reasons stated
In Section c(l). The 2-year chronic dog study was rereviewed
and found adequate for regulatory purposes. It Is recommended
that the ADI continue to be based on this chronic dog study.
Using a 100-fold safety factor and the 100 ppm (2.5 mg/kg)
NOEL from the dog study, the ADI was determined to be 0.025
mg/kg/day with a Maximum Permissible Intake (MPI) of 1.5 mg/kg
for a 60 kg adult human. Theoretical maximum residue contri-
bution (TMRC) for metribuzin based on established tolerances
is 0.3508 mg/day for a 1.5 kg diet. Currently, the permanent
tolerances utilize 23.39 percent of the ADI.
The Agency is unable to complete a full tolerance reassessment
because the available metribuzin toxicology and residue data
do not fully support the established tolerances listed below.
The metabolism of metribuzin in animals is not fully under-
stood. Therefore, the Agency is requiring data on metabolism
of metribuzin and related metabolites in ruminants, poultry
and several crops. An acceptable long-term rat study is
required. The additional data will be used to assess dietary
exposure to metribuzin and may lead to revisions in the
existing tolerances. Therefore, the Agency will not grant
any pending significant or new tolerances for metribuzin
until the data are submitted.
In the United States, tolerances are currently established in
40 CPR Section 180.332 for the combined residues of the herbi-
cide, 4-amlno-6-(l,l-dimethylethyl)-3-(methythio)-l,2,4-triazin-
5(4H)-one and its trlazlnone metabolites in or on the raw agri-
cultural commodities listed below:
Commodities Parts Per Million
Alfalfa, green 2.0
Alfalfa, hay 7.0
Asparagus 0.05
Barley grain 0.75
Barley, straw 1.0
Cattle, fat 0.7
Cattle, mbyp 0.7
Cattle, meat 0.7
Corn, fodder 0.1
Corn, forage 0.1
Corn, fresh (inc. sweet k +CWHR) 0.05
Corn, grain (inc. popcorn) 0.05
Eggs 0.01
Goats, fat 0.7
Goats, mbyp 0.7
Goats, meat 0.7
13
-------
Grass 2.0
Grass, hay 7.0
Hogs, fat 0.7
Hogs, mbyp 0.7
Hogs, meat 0*7
Horses, fat 0.7
Horses, mbyp 0.7
Horses, meat 0.7
Lentils (dried) 0.05
Lentils, forage 0.5
Lentils, vine hay 0.05
Milk 0.05
Peas 0.1
Peas (dried) 0.05
Peas, forage 0.5
Peas, vine hay 0.05
Potatoes 0.6
Poultry, fat 0.7
Poultry, mbyp 0.7
Poultry, meat 0.7
Sainfoin 2.0
Sainfoin, hay 7.0
Sheep, fat 0.7
Sheep, mbyp 0.7
Sheep, meat 0.7
Soybeans 0.1
Soybeans, forage 4.0
Soybeans, hay 4.0
Sugarcane 0.1
Tomatoes 0.1
Wheat, forage 2.0
Wheat, grain 0.75
Wheat, straw 1.0
In the United States tolerances are currently established
in 21 CPR 193.25 for the combined residues of the herbicide
4-amino-6-(l,l-dimethylethyl)-3-(methylthio)-l,2,4-triazin-
5(4H)-one and its triazinone metabolites in or on the
following processed foods when present therein as a result
of application of this herbicide to growing crops:
Food Parts Per Million
Barley, milled fractions 3.0
(except flour)
Potatoes, processed 3.0
(inc. potato chips)
Sugarcane molasses 2.0
Wheat, milled fractions 3.0
(except flour)
14
-------
In the United States tolerances are currently established
in 21 CPR 561.41 for combined residues of the herbicide
*»-amino-6-(1,1-dimethylethyl)-3-(methylthio)-1,2,4-triazin-
5(MH)-one and its triazinone metabolites in the following
processed feeds when present therein as a result of
application of this herbicide to growing crops:
Peed Parts Per Million
Barley, milled fractions 3.0
(except flour)
Potato waste, processed 3.0
(dried)
Sugarcane bagasse 0.5
Sugarcane molasses 0.3
Tomato pomace, dried 2.0
(Wheat, milled fractions 3.0
(except flour)
International Tolerances
Canadian Tolerances
Tolerances for residues of metrlbuzin are established in Canada
for asparagus at 0.1 ppm, barley grain at 0.1 ppm, lentils at
0.1 ppm, peas at 0.1 ppm, potatoes at 0.5 ppm, soybeans at 0.1
ppm, tomatoes at 0.1 ppm and wheat grain at 0.1 ppm. Although
these tolerances differ from those in the United States, it is
inappropriate for the Agency to harmonize these tolerances at
the present time because of the extensive toxicology and
residue chemistry data gaps. At the time the indicated
data gaps for residue chemistry and toxicology are filled
we will reassess harmonizing these tolerances.
There are no tolerances for residues of metribuzln in Mexico
or Codex Allmentarlus.
15
-------
EPA Index to Pesticide Chemicals
hlOHOl 4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE*
TYPE PESTICIDE; Herbicide
FORMULATIONS ;
FI
WP (50%, 70%, 75%)
F1C (4 Ib/gal)
GENERAL WARNINGS AND LIMITATIONS; A selective herbicide used for pre-
emergence or early postemergence control of certain grasses and broadleaf
weeds. Moisture is necessary to activate the chemical; for best results
apply to moist soil. Rainfall or sprinkler irrigation within 2 weeks af-
ter application will improve effectiveness. Degree and duration of con-
trol will vary with dosage, soil type, soil texture, rainfall and other
conditions. Heavy rains soon after application will cause injury to the
crop. For best results, postemergence applications should be made when
weeds are less than 1.5 inches tall. Where a dosage range is given, use
the lower dosage on coarse and medium textured soils or soils with lower
organic matter content (0.5 to 2 percent); use the higher dosage on fine
soils or soils with higher organic matter content (more than 2 percent).
Silty clay loams are transitional soils which may be classified as medium
soils in some regions of the United States, and as fine soils in other
regions. Do not use on sandy soils. When tank mixes are used, observe
all cautions and limitations given on the labeling of tank mix chemicals.
Apply in 10 to 40 gallons of water per acre by ground or 2 to 10 gallons
by air; unless otherwise noted. Tolerances have been established for the
combined residues of metribuzin and its triazinone metabolites.
Livestock Tolerances;
Cattle (fat, meat, mbyp) 0.7 ppm
Eggs 0.01 ppm
Goats (fat, meat, mbyp) 0.7 ppm
Hogs (fat, meat, mbyp) 0.7 ppm
Horses (fat, meat, mbyp) 0.7 ppm
Milk 0.7 ppm
Poultry (fat, meat, mbyp) 0.7 ppm
Sheep (fat, meat, mbyp) 0.7 ppm
DEFINITION OF TERMS;
K+CWHR 3 kernel plus cob with husk removed
mbyp • meat byproducts
Ib = pounds
a.i. = active ingredient
*Metribuzin
Lexone
Sencor
4-amino-6-tert-butyl-3-(methylthio)-as-triazin-5(4H)-one
Issued: 11-01-83 I-lOllOl-l 1 6
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
TIME REQUIRED FOR CONTROL; Not located.
PHYTOTOXICITY TO TARGET WEEDS; Not located.
PHYTOTOXICITY TO CROPS; Not located.
MODE OF ACTION; Inhibits photosynthesis.
BROADLEAF WEEDS CONTROLLED;
PBFADAA Ageratum
PCQAUAA Beggarweed
PBKAKBA Blue mustard
PEWAIBF Buffalobur
PZAAABW Bur buttercup
PFFAFBA Bur beakchervil
PADABBA Carpetweed
PAZAAAC Chickweed
PBFDQAA Cocklebur
PCQATBA Coffeeweed
PAZAOBB Common chickweed
PBFDQBD Common cocklebur
PEDADBA Common purslane
PBFAEBA Common ragweed
PBFBUBA Common sunflower
PAZALBB Conical catchfly
PAZABBA Corn cockle
PEUAPBB Corn speedwell
PAZAPBA Cow cockle
PEAAHBE Curly dock
PBFDHAA Dandelion
PBEABAA Dayflower
PBFBIBB Dogfennel
PBKAGAA Falseflax
PARABAA Fiddleneck
PBGACBB Field bindweed
PBKBFBA Field penneycress
PBZABAA Filaree
PDNABBA Fireweed
PBKANBE Flixweed
PCQAUBC Florida beggarweed
PEMAEBB Florida pusley
PEYACBA Florida waltheria
PBXABBA Fumitory
PBFBOAA Galinsoga
PBVAGBH Garden spurge
PBFAEBE Giant ragweed
PBDAEAA Goosefoot
PBVAGBW Graceful spurge
PARAJAA Cromwell
PEWAIBG Hairy nightshade
Issued: 11-01-83
(a)
(a)
(a)
(a)
(a)
(c)
(aXbXc)
(c)
(b)
(d)
1-101101-2
17
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
BROADLEAF WEEDS CONTROLLED (continued)
PCQBFBB Haole koa
PCQBSBB Hemp sesbania
PCOAFBA Henbit
PCQAUBA Hoary tickclover
PBVABBB Hophornbeam copperleaf
PEWAIBB Horsenettle
PEUAPBE Ivyleaf speedwell
PAAAABK Jacob's ladder
PAZAGBJ Jagged chickweed
PEWADBD Jimsonweed
PEAAGAC Knotweed
PBDA1BA Kochia
PEAAGBP Ladysthumb
PBDAEAB Lambsquarters
PBKBDBB London rocket
PARADBA Madwort
PDAAHAA Mallow
PBFAYBA Marestail
PBFAHBB Mayweed
PBFDKBC Meadow salsify
PEMAEAA Mexican clover
PBVACBA Mexicanweed
PEDACBA Minerslettuce
PBGAAAB Morningglory
PAZADBC Mouseear chickweed
PBKAAAC Mustard
PELAZBA Parsley-piert
PEAAGBO Pennsylvania smartweed
PBKAWAA Pepperweed
PAAAABI Pigweed
PBFCKBB Pineappleweed
PDAAJBF Prickly sida
PBFCEBF Prickly lettuce
PEAAGBD Prostrate knotweed
PAFACBC Prostrate pigweed
PBKAAAD Purple mustard
PCQARBE Rattlebox
PEAAHBB Red sorrel
PBFBFBA Red tassleflower
PAFACBI Redroot pigweed
PBZABBB Redstem filaree
PBFBHBF Rough fleabane
PBFARBI Russian knapweed
PBDAKBA Russian thistle
PCQBKBC Sensitiveplant
PBKAHBA Shepherdspurse
PCQAMBF Sicklepod
PEAAGAD Smartweed
PAFACBE Smooth pigweed
PBFDCAA Sowthistle
PEUAPAA Speedwell
Issued: 11-01-83
(a)
(a)
(c)
(a)
(c)
(c)
(a)
(a)
(c)
(a)
(c)
1-101101-3
18
-------
PAFACBJ
PAFACBD
PBVAGBK
PBVA6AA
PDAACBA
PZAAA6J
PFGAEBA
PBFBUAA
PBKANBB
PAAAACD
PARABBC
PEUAIAA
PBKASAA
PBKBDBA
PDAABBB
PDAAEBC
PAZAHBA
PEAAGBH
PBKAFBE
PBVAGAB
PBKADBB
(a)
EPA Index to Pesticide Chemicals
4-AMINO-6-U,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
BROADLEAF WEEDS CONTROLLED (continued)
Spiny amaranth
Spleen amaranth
Spotted spurge
Spurge
Spurred anoda
Spurweed
Stinging nettle
Sunflower
Tansymustard
Tarweed
Tarweed fiddleneck
Toadflax
Treacle mustard
Tumble mustard
Velvetleaf
Venice mallow
White cockle
Wild buckwheat
Wild mustard
Wild poinsettia
Yellow rocket
(a)
(0
(aXc)
(a)
(a)
(a)
(a)
(bXc)
(a)
(a) Control achieved by preemergence use*
(b) Partial control only*
(c) Control achieved by postemergence use.
(d) Suppression only; apply before plants are 1 inch tall.
GRASSES AND OTHER MONOCOTS CONTROLLED;
PCAARBC Alexandergrass
PCACKBA Annual bluegrass
PCABHBB Barnyardgrass (a)(b)(c)
PCACKAA Bluegrass (c)
PCACUBE Bristly foxtail
PCACEBA Broadleaf panicum
PCAARBD Broadleaf signalgrass (b)(c)
PCACKBB Bulbous bluegrass
PCAATBK Cheat
PCABFAA Crabgrass (b)(c)
PCABCBA Crowfootgrass (a)
PBEABAA Dayflower (c)
PCAATBM Downy brome (a)
PCACEBD Fall panicum (a)
PCAAWBB Field sandbur
PCACUAA Foxtail (b)(c)
PCABSBC Foxtail barley
PCACUBA Giant foxtail (c)
PCABIBA Goosegrass (c)
PCACUBF Green foxtail (c)
PCACEBH Guineagrass
Issued: 11-01-83
1-101101-4
19
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
GRASSES AND OTHER MONOCOTS CONTROLLED (continued)
PCABZBA Italian ryegrass
PCAATBF Japanese brome
PCACWBG Johnsongrass (seedling)
PCABFBF Large crabgrass
PCABSBF Little barley
PCAAOAA Oat
PCAAFBC Pacific meadow foxtail
PCAACBA Quackgrass
PCAAXBD Radiate fingergrass
PCAATBN Rescuegrass
PCACDAA Ricegrass
PCAATBI Ripgut brome
PCAARAA Signalgrass
PCAATBE Smooth brome
PCABFBD Smooth crabgrass
PCADFBA Wheat (volunteer)
PCABSBD Wild barley
PCAAOBB Wild oat
PCAAJBA Windgrass
PAAAABC Wiregrass
PCACUBD Yellow foxtail
PBMADBI Yellow nutsedge
(c)
(a)
(a)
(a)
(c)
(a) Control achieved by preemergence use
(b) Partial control only.
(c) Control acheived by postemergence
Issued: 11-01-83
1-101101-5
20
-------
'28069AA
EPA Index to Pesticide Chemicals
4-AMINO-6-C1,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Site. Dosage Tolerance. Use. Limitations
and Formulation
(Ib a.i./A)
TERRESTRIAL FOOD CROP
(Agricultural Crops)
General Warnings and Limitations; Potatoes, soybeans, sugarcane, and
tomatoes may be planted in treated areas 4 months after application of
metribuzin. Barley and winter wheat may also be planted in treated
areas 4 months after application to lentils, peas or soybeans* Alfalfa,
asparagus, barley, corn, cotton, forage grasses, lentils, peas, rice
and wheat may be planted in treated areas 8 months after application.
All other crops may be planted 18 months after application. Do not ap-
ply to rotational crops during the same year as the first application.
Cover crops may be planted any time after application, but treated areas
should not be grazed, or the cover crop harvested for food or feed.
Stand reduction of these crops may occur in some areas.
Alfalfa
0.38-1
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.75-1
(50% WP)
(75% WP)
(4 Ib/gal FIG)
2 ppm (green alfalfa and grasses)
7 ppm (alfalfa and grass hay)
Twenty-eight day preharvest interval. Do not
graze treated areas within 28 days after applica-
tion.
General Information; Use only on a dormant es-
tablished crop. Do not apply after growth begins
in spring or before growth ceases in fall. May
be applied to stands of alfalfa mixed with grass-
es; the higher dosages will result in reduction
of forage grass stands. Do not use on sand or on
soils with less than 0.5 percent organic matter
content. In areas west of the Rocky Mountains,
avoid using on soils with calcareous surface
layer, high levels of lime or sodium and a pH
greater than 7.5. May be applied to alfalfa in
conjunction with a fluid fertilizer or impregnated
on dry bulk fertilizer.
Dormant application. Broadcast* Make a single
application in the fall after plants become dor-
mant or in the spring before new growth starts.
Use the lower dosage on sandy loam, or loamy sand
soils in areas other than ID, OR and WA.
Dormant application. Broadcast. Apply to reduce
stands of forage grasses, to prevent crowding out
of alfalfa.
Issued: 11-01-83
1-101101-6
21
-------
/16002AA
EPA Index to Pesticide Chemicals
4-AMINO-6- ( 1 , l-DIMETHYLETHYL)-3-(METHYLTHIO )-l , 2 , 4-TRIAZIN-5 (AH)-ONE
Site, Dosage Tolerance, Use, Limitations
and Formulation
(Ib a.i./A)
Alfalfa (continued)
0.25-0.38
(50% WP)
(75% WP)
(4 Ib/gal FIG)
0.25-0.75
(50% WP)
(75% WP)
(4 Ib/gal F1C)
Asparagus
(50% WP)
(75% WP)
(4 Ib/gal F1C)
(50% WP)
(75% WP)
(4 Ib/gal FIG)
(50% WP)
(75% WP)
(4 Ib/gal F1C)
use limited to ID, OR and WA. Dormant applica-
tion. Broadcast. For the control of common
chick weed. Apply to sandy loam or loamy sand
soils.
Use limited to WA. Dormant application. Broad-
cast. Make a single application to established
alfalfa during the dormant season.
Tank mix with paraquat.
0.05 ppm
Fourteen day preharvest interval.
2 Ib a.i./A per crop season.
Do not exceed
General Information; Do not use on newly seeded
asparagus or on young plants from crowns during
the first growing season. Do not make postharvest
applications until all spears have been harvested.
Preemergence. Broadcast. Make a single applica-
tion in the early spring before spears or ferns
emerge.
Preemergence. Broadcast. Split application.
Apply before spears or ferns emerge, and follow
with postharvest treatment.
AND
Postharvest. Broadcast. Split application to
follow preemergence treatment. Apply after last
harvest of the season, but prior to fern emer-
gence.
Issued: 11-01-83
1-101101-7
22
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
/28063AA
Site, Dosage
and Formulation
(Ib a.i./A)
Barley
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.34-0.75
(50% WP)
(75% WP)
(4 Ib/gal F1C)
Tolerance, Use, Limitations
0.75 ppm (grain)
1 ppm (straw)
3 ppm (milled fractions (except flour) of
processed food and feed)
Do not graze or harvest treated barley for feed
before crop maturity. Do not graze treated fields
after a fallow application*
General Information: Do not apply more than once
per crop season. Do not apply in the spring if a
fall fallow application was made. Do not plant
spring cereals following fall fallow applications.
Use limited to areas east of the Cascade Mountains
in ID, OR, UT, MO and WA on the varieties Compana,
Hannchen, Hector, Hudson, Luther, Kamiak, Klages,
Olympic, Piroline and Steptoe. Postemergence.
Broadcast. Apply after barley has fully tillered
and developed secondary roots, but before joint-
ing. Do not apply on any soil containing less
than 1 percent organic matter. Do not use if
soils are high in lime or sodium or have a pH
greater than 7.7. Temporary chlorosis may occur
especially if the crop is under stress or if ap-
plication is made in fluid fertilizer.
May be tank mixed with dicamba, dimethylamine
salt; 2,4-D; bromoxynil; terbutryn; chlorsulfuron;
or bromoxynil and MCPA.
Use limited to KS, OK and TX. Postemergence.
Broadcast. Apply prior to jointing when crop is
well tillered (at least 3 tillers) and has devel-
oped 2 inch secondary roots throughout the field.
Do not use on coarse textured soils with less
than 2 percent organic matter.
May be tank mixed with dicamba, dimethylamine
salt; 2,4-D; bromoxynil; terbutryn; chlorsulfuron;
or bromoxynil and MCPA.
Postharvest. Broadcast. For use on fallow land
to be planted to winter wheat. Apply after weed
emergence.
Tank mix with propham; paraquat; glyphosate; or
chlorsulfuron if large weeds are present.
Issued: 11-01-83
1-101101-8
23
-------
EPA Index to Pesticide Chemicals
4-AMINO-6- (1,1-DIMETHYLETHYL ) -3- (METHYLTHIO )-l, 2,4-TRIAZIN-5 ( 4H ) -ONE
/28005AA
Site, Dosage
and Formulation
(Ib a.i./A)
Barley (continued)
0.5-0.75
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.34-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.63-0.75
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.38-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
Corn
0.25-0.5
(50% WP)
Tolerance, Use, Limitations
Use limited to CO, ID, KS, MT, NE, ND, OK, OR, SD,
TX, UT and WA. Postharvest. Broadcast. Apply
to actively growing weeds in fall fallow.
Tank mix with propham; paraquat; glyphosate; or
chlorsulfuron, if large weeds are present.
Use limited to CO, ID, KS, MT, NE, ND, OK, OR, SD,
XX, UT and WA. Postharvest. Broadcast. Apply
to actively growing weeds in spring fallow.
Tank mix with propham; paraquat; glyphosate; or
chlorsulfuron, if large weeds are present.
Use limited to CO, KS, MT, NE and WY. Postharvest
application in fall fallow. Broadcast. Apply
prior to weed emergence. Do not plant crops in
treated areas earlier than 10 months following
fall applications. Do not make another applica-
tion in spring.
Tank mix with paraquat; glyphosate; or other
contact herbicide if weed growth is present.
Use limited to CO, KS, MT, NE and WY. Spring ap-
plication in summer fallow. Broadcast. Apply
prior to weed emergence. Barley can be seeded
120 days after spring application.
Tank mix with paraquat; glyphosate; or other
contact herbicide if weed growth is present.
0.1 ppm (forage, fodder)
0.05 ppm (grain and fresh (including sweet
K+CWHR))
Use limited to IA, KS, MN, MO and NE. Preemer-
gence. Broadcast. Plant corn 1.5 inches deep.
Do not use on inbred parent seed corn. Do not
use on corn planted in deep furrows.
Tank mix with alachlor.
Issued: 11-01-83
1-101101-9
24
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(1,1-DIMETHYLETHYL)-3-(METHYLTHIO)-1,2,4-TRIAZIN-5(4H)-ONE
Tolerance, Use, Limitations
/28006AA
Site, Dosage
and Formulation
(lb a.i./A)
Corn. Field
0.25
(75% WP)
(4 Ib/gal F1C)
/14013AA
Potato
0.5-1
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.1 ppm (forage, fodder)
0.05 ppm (grain and fresh (including sweet
K+CWHR))
Use limited to IL, IN, IA, KS, KY, MI, MO, NE,
OH, SD and WI. Preemergence. Broadcast. Plant
corn 1.5 inches deep. Use on hybrid seed corn
only if both parent corn varieties are known to
be tolerant to metribuzin and other tank mix
chemicals.
Tank mix with atrazine and alachlor; atrazine and
metolachlor; alachlor and bladex; or bladex and
metolachlor.
0.6 ppm
3 ppm (processed food (including potato chips))
3 ppm (processed feed (dried potato waste))
Sixty day preharvest interval. Do not apply more
than 1 Ib a.i./A per crop season.
General Information; Do not use on early ma-
turing smooth-skinned white or red-skinned vari-
eties when applying postemergence. Apply only to
those varieties that are known to be tolerant to
metribuzin. Crop injury may result when used on
sands or loamy sands containing 0.5 to 1 percent
organic matter. Do not use on any soil containing
less than 0.5 percent organic matter. Preemer-
gence use on soils containing more than 10 percent
organic matter may result in only partial weed
control. Do not use on potatoes grown under
rill/furrow irrigation.
Preemergence. Broadcast. Apply as a single ap-
plication after planting or after drag-off but
before crop emergence.
May be tank mixed with alachlor or pendimethalin.
Do not tank mix with pendimethalin in CA.
Postemergence. Broadcast. Apply as a single ap-
plication. Three successive days of sunny weather
are necessary prior to application. Some chloro-
sis or minor necrosis may occur to crop plants.
Application may follow a preemergence application
provided no more than 1 Ib a.i./A per season is
applied.
Issued: 11-01-83
1-101101-10
25
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(1,l-DIMETHYLETHYL)-3-(METHYLTHIO)-1,2,4-TRIAZIN-5(4H)-ONE
Site, Dosage Tolerance, Use, Limitations
and Formulation
(Ib a.i./A)
Potato (continued)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.13-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
Postemergence application via sprinkler irrigation
systems. Apply uniformly in 0.25 to 0.75 inches
of water per acre. On sandy soil, apply in 0.25
to 0.5 inch of water. Make a single postemergence
or a split postemergence application. Application
may follow a preemergence application provided no
more than 1 Ib a.i./A per season is applied.
Use limited to ID, OR and WA. Postemergence.
Broadcast. Make 2 applications, but use only if
a preemergence application was not made. Make
the first application early in the season and
allow at least 14 days between applications. Do
not apply within 24 hours of application of other
pesticides. On coarse soils containing 0.5 to 1
percent organic matter do not exceed 0.25 Ib
a.i./A per application in OR and WA. Do not
apply after June 30 if treated field is to be
planted to crops other than potatoes.
Use limited to ID. Postemergence. Broadcast.
Make 2 applications, but use only if a preemer-
gence application was not made. On coarse soils
containing 0.5 to 1 percent organic matter, do
not exceed 0.38 Ib a.i./A per application. Allow
14 days between applications, and do not apply
within 24 hours of application of other pesti-
cides.
Use limited to OR and WA. Postemergence. Broad-
cast. Make 2 applications, but use only if a
preemergence application was not made. Do not
exceed the lower dosage on coarse soils containing
0.5 to 1 percent organic matter. Allow 14 days
between applications, and do not apply within 24
hours of application of other pesticides.
Issued: 11-01-83
.1-101101-11
26
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-C1,l-D!METHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Tolerance, Use, Limitations
/28077AA
Site, Dosage
and Formulation
Ub a.i./A)
Sainfoin
0.38-1
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.38
{50% WP)
(75% WP)
(4 Ib/gal F1C)
2 ppm (sainfoin and grasses)
7 ppm (sainfoin and grass hay)
Twenty-eight day preharvest interval. Do not
graze within 28 days after application.
General Information; Use only on a dormant es-
tablished crop. Do not apply after growth begins
in spring or before growth ceases in fall. May
be applied to stands of sainfoin mixed with
grasses; the higher dosages will result in reduc-
tion of forage grass stands. Do not use on sand
or on soils with less than 0.5 percent organic
matter content. In areas west of the Rocky Moun-
tains, avoid using on soils with calcareous sur-
face layer, high levels of lime or sodium and a
pH greater than 7.5.
Dormant application. Broadcast. Make a single
application in the fall after plants become dor-
mant or in the spring before new growth starts.
Use the lower dosage on sandy loam, or loamy sand
soils in areas other than ID, OR and WA. When
application is made to mixed stands with forage
grasses, the higher rates may provide partial re-
duction of forage grass stands. Dosage rates of
0.75 to 1 Ib a.i./A may severly reduce stands of
forage grass.
Use limited to ID, OR and WA. Dormant applica-
tion. Broadcast. For the control of common
chickweed. Apply to sandy loam or loamy sand
soils.
Issued: 11-01-83
1-101101-12
27
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DlMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Tolerance, Use, Limitations
/15010AA
Site, Dosage
and Formulation
(Ib a.i./A)
Soybeans
0.1 ppm (soybeans)
4 ppm (forage, hay)
Do not use treated vines for feed or forage for
40 days after application.
General Information; Altona,•Coker 102 and 156,
Govan, Semmes, Tracy and Vansoy are sensitive to
metribuzin and injury may occur if used on these
varieties. Determine tolerance to other varieties
before implementing as a field practice. Injury
may occur if used on soils having a calcareous
surface layer or a pH of 7.5 or higher, if used
in conjunction with soil applied organic phosphate
pesticides, or if atrazine was applied on the
soil the previous year. If initial seeding fails
to produce a stand, treated fields may be re-
planted to soybeans, but do not rework soil, or
retreat field with a second application. Do not
replant treated areas to any crop other than soy-
beans within 4 months after application as injury
to subsequent crops may result. For crop rota-
tions in fields treated with chloramben, triflur-
alin, glyphosate, oryzalin, profluralin, flu-
chloralin, or metolachlor, follow instructions on
individual product labels. When applying pre-
emergence, use the higher dosage for minimum till
or no-till soybeans, and in the States of GA and
SC. May be applied in conjunction with fluid
fertilizers, or may be impregnated on dry bulk
fertilizer. Plant seeds at least 1.5 inches deep.
Do not use on coarse textured soils with less
than 2 percent organic matter, or on sandy soils
when applying preemergent broadcast applications.
Guidelines for preplant incorporated, tank mixed
applications that are followed by a preemergence
surface application are: On coarse textured soils,
do not use on sand soils with less than 1 percent
organic matter, or on loamy sand or sandy loam
soils with less than 0.5 percent organic matter;
On coarse textured soils with a calcareous surface
layer or a pH of 7.5 or higher, do not use on
sand soils with less than 2 percent organic
matter, or on loamy sand or sandy loam soils with
less than 1 percent organic matter; On medium and
fine textured soils, do not use when the organic
matter content is less than 0.5 percent.
Issued: 11-01-83
1-101101-13
28
-------
ucA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Site, Dosage
and Formulation
Tib a.i./A)
Soybeans (continued)
0.25-0.5
(4 Ib/gal FIG)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.5
(4 Ib/gal F1C)
0.25-0.5
(50% WP)
(4 Ib/gal FIG)
0.13-0.5
(4 Ib/gal F1C)
0.75
(4 Ib/gal FIG)
0.5-0.63
(75% WP)
0.75
(4 Ib/gal FIG)
0.5-0.63
(4 Ib/gal F1C)
0.25-0.5
(4 Ib/gal FIG)
Tolerance, Use, Limitations
Preplant. Broadcast. Apply within 4 weeks of
planting.
Tank mix with oryzalin.
Preplant. Soil incorporation. Apply within 2
weeks of planting.
Tank mix with trifluralin; alachlor; fluchloralin;
or metolachlor.
Preplant. Soil incorporation. Apply within 7
days of planting.
Tank mix with alachlor.
Preplant. Soil incorporation.
days of planting.
Tank mix with profluralin.
Apply within 10
Preplant. Soil incorporation. Apply within 2
weeks of planting.
Tank mix with chloramben and trifluralin.
Use limited to silty clay to heavy clay soils in
the Mississippi Delta. Preplant. Soil incorpor-
ation. Apply within 7 days of planting.
Tank mix with alachlor.
Use limited to silty clay to clay soils of the
Mississippi Delta. Preplant. Soil incorporation.
Apply within 2 weeks of planting.
Tank mix with alachlor or metolachlor.
Use limited to silty clay to heavy clay soils in
the Mississippi Delta. Preplant. Broadcast.
Apply within 4 weeks of planting.
Tank mix with oryzalin.
Preplant. Soil incorporation. Follow with pre-
emergence surface application.
Tank mix with trifluralin; alachlor; pendimethal-
in; or metolachlor.
0.13-0.5
(4 Ib/gal F1C)
Preemergence.
AND
Broadcast.
Issued: 11-01-83
1-101101-14
29
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Site, Dosage
and Formulation
(Ib a.i./A)
Soybeans (continued)
0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.13-0.38
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.38
(50% WP)
(75% WP)
(4 Ib/gal F1C)
Tolerance, Use, Limitations
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.13-0.25
(50% WP)
(75% WP)
(4 Ib/gal F1C)
Preplant. Soil incorporation. Broadcast. For
use on fine textured soils.
Tank mix with alachlor; fluchloralin; metolachlor;
pendimethalin; or trifluralin.
AND
Preemergence. Broadcast.
Preplant. Soil incorporation. For use on fine
textured soils having a calcareous surface layer
or a pH of 7.5 or higher, and in areas where soils
within a field vary extremely in texture or or-
ganic matter content.
Tank mix with trifluralin; alachlor; pendimethal-
in; fluchloralin; or metolachlor.
AND
Preemergence. Reduce dosage by 0.13 Ib a.i./A
when applying on soils with over 4 percent organic
matter and having a calcareous surface layer or a
pH of 7.5 or higher.
Preplant. Soil incorporation. For use on coarse
textured soils.
Tank mix with trifluralin; alachlor; pendimethal-
in; fluchloralin; or metolachlor.
AND
Preemergence.
Issued: 11-01-83
1-101101-15
30
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-U,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-S(4H)-ONE
Site. Dosage Tolerance, Use, Limitations
and Formulation
Tib a.i./A5
Soybeans (continued)
^•25 Preplant. Soil incorporation. For use on medium
(50% WP) textured soils having a calcareous surface layer
(75% WP) or a pH of 7,5 Or higher, and in areas where soils
(4 Ib/gal F1C) within a field vary extremely in texture or or-
ganic matter content.
Tank mix with trifluralin; alachlor; pendimethal-
in; fluchloralin; or metolachlor.
AND
0.25-0.5 Preemergence. Reduce dosage by 0.13 Ib a.i./A
(50% WP) when applying on soils with over 4 percent organic
(75% WP) matter and having a calcareous surface layer or a
(4 Ib/gal F1C) PH of 7.5 or higher.
0*38 Preplant. Soil incorporation. For use on medium
(50% WP) textured soils.
(75% WP) Tank mix with trifluralin; alachlor; pendimethal-
(4 Ib/gal F1C) in; fluchloralin; or metolachlor.
AND
0.13-0.38 Preemergence.
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.5 Use limited to the Southern States and Eastern
(50% WP) Coastal Plains (AL, AR, FL, GA, LA, MS, NC, OK,
(75% WP) SC, TN, TX, Southeastern MO (Bootheel Region),
(4 Ib/gal F1C) and Coastal Plains of DE, MD, NJ and VA). Pre-
plant. Soil incorporation. Incorporate and plant
within 7 days after application.
Tank mix with pendimethalin.
AND
0.25-0.5 Use limited to the Southern States and Eastern
(50% WP) Coastal Plains (AL, AR, FL, GA, LA, MS, NC, OK,
(75% WP) SC, TN, TX, Southeastern MO (Bootheel Region),
(4 Ib/gal F1C) and Coastal Plains of DE, MD, NJ and VA). Pre-
emergence. May be preceded by preplant soil in-
corporation of pendimethalin alone.
Issued: 11-01-83 1-101101-16
31
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Site, Dosage Tolerance, Use, Limitations
and Formulation
(Ib a.i./A)
Soybeans (continued)
0.38-0.5 use limited to the Northeastern and Northcentral
(50% WP) States (IL, IN, IA, KS, KY, MI, MN, NE, NY, ND,
(4 Ib/gal F1C) OH, PA, SD, WI, MO (except Bootheel Region), and
except for the Coastal Plain, DE, MD, NJ and VA).
0.25-0.63 Preplant. Soil incorporation. Incorporate and
(75% WP) plant within 7 days after application.
Tank mix with pendimethalin.
AND
0.38-0.5 Use limited to the Northeastern and Northcentral
(50% WP) States (IL, IN, IA, KS, KY, MI, MN, NE, NY, ND,
(4 Ib/gal F1C) OH, PA, SD, WI, MO (except Bootheel Region), and
except for the Coastal Plain, DE, MD, NJ and VA).
0.25-0.63 Preemergence. May be preceded by preplant soil
(75% WP) incorporation of pendimethalin alone.
0.38-0.88 Preemergence. Broadcast or band.
(75% WP)
0.38-0.5 Use limited to AL, LA, MS and TN. Preemergence.
(4 Ib/gal F1C) Broadcast. For use on medium textured soils.
0.5-0.63 Use limited to AL, LA, MS and TN. Preemergence.
(4 Ib/gal F1C) Broadcast. For use on fine textured soils.
0.75-1 Use limited to the Mississippi Delta. Preemer-
(75% WP) gence. Broadcast or band.
0.25-0.38 Preemergence. Broadcast. For use on alkaline
(4 Ib/gal F1C) soils. Use the lower dosage on medium textured
soils and the higher dosage on fine textured
soils containing more than 0.5 percent organic
matter. Use the higher dosage where soil pH is
less than 7.5 and weed pressure is heavy. The
lower dosage may be used as a preemergence surface
application following preplant soil incorporation
of trifluralin or profluralin.
Issued: 11-01-83 1-101101-17
-------
ndex to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Site, Dosage Tolerance, Use, Limitations
and Formulation
(Ib a.i./A)
Soybeans (continued)
0.25-0.38
(75% WP)
0.38-0.75
(4 Ib/gal F1C)
0.38-1
(75% WP)
0.25-1
(75% WP)
0.25-0.5
(75% WP)
0.13-0.5
(50% WP)
(4 Ib/gal F1C)
0.13-0.5
(75% WP)
(4 Ib/gal F1C)
0.25-0.63
(75% WP)
0.13-0.5
(4 Ib/gal FIG)
Use limited to calcareous soils of MN and ND.
Preemergence. Broadcast or band. Apply the lower
dosage on medium textured soils, and the higher
dosage on fine textured soils regardless of soil
organic matter content, and where soil pH is less
than 7.5 and weed pressure is heavy. The lower
dosage may be applied alone or as a preemergence
surface application following a preplant applica-
tion of trifluralin.
Use limited to the Midsouth. For the control of
hophornbeam copperleaf. Preemergence. Broadcast.
Preemergence. Broadcast. For use in areas where
soybeans will be planted in preformed beds, cover
crops or in previous crop residues. Apply with a
nonionic surfactant.
Tank mix with paraquat.
Preemergence. Broadcast. For use in areas where
soybeans will be planted in preformed beds, cover
crops or in previous crop residues. Apply with a
nonionic surfactant.
Tank mix with paraquat and alachlor.
Preemergence. Broadcast. For use in areas where
soybeans will be planted in preformed beds, cover
crops or in previous crop residues. Apply with a
nonionic surfactant within 2 days after planting.
Tank mix with paraquat and oryzalin.
Preemergence. Broadcast. Plant seed 1.5
inches deep on flat or raised seedbeds.
Tank mix with alachlor.
to 2
Preemergence. Broadcast. Apply within 2 days
after planting.
Tank mix with oryzalin.
Preemergence. Broadcast.
Tank mix with chloramben.
Issued: 11-01-83
1-101101-18
B3
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-S(4H)-ONE
Site, Dosage
and Formulation
(Ib a.i./AJ
Soybeans (continued)
0.38-0.5
(50% WP)
(4 Ib/gal F1C)
0.25-0.62
(75% WP)
0.13-0.5
(75% WP)
(4 Ib/gal F1C)
0.25-0.62
(75% WP)
0.25-0.5
(4 Ib/gal F1C)
0.25-0.5
(4 Ib/gal F1C)
0.13-0.5
(4 Ib/gal F1C)
Tolerance, Use, Limitations
0.13-0.5
(4 Ib/gal FIG)
(75% WP)
Preemergence. Broadcast or band. May be preceded
by a preplant soil incorporation of trifluralin;
profluralin; pendimethalin; fluchloralin; or
metolachlor.
Preemergence. Broadcast.
Tank mix with linuron and alachlor; linuron and
metolachlor; or alachlor, sodium naptalam and
sodium dinoseb.
Preemergence. Broadcast or band.
Tank mix with alachlor.
Preemergence. Broadcast. Sequential application.
Apply after a preplant soil incorporation of flu-
chloralin.
OR
Preplant. Soil incorporation.
Tank mix with fluchloralin.
Preemergence. Broadcast.
Tank mix with chloramben and alachlor; chloramben
and pendimethalin; chloramben and metolachlor; or
alachlor, sodium naptalam and sodium dinoseb.
OR
Preplant. Soil incorporation.
Tank mix with chloramben and alachlor; chloramben
and pendimethalin; chloramben and metolachlor; or
alachlor, sodium naptalam and sodium dinoseb.
Use limited to silty clay to heavy clay soils of
the Mississippi Delta. Preemergence. Broadcast
or band.
Tank mix with alachlor.
Issued: 11-01-83
1-101101-19
34
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TEL[AZIN-5(4H)-ONE
Site, Dosage
and Formulation
(Ib a.i./A)
Soybeans (continued)
0.5-0.75
(50% WP)
(4 Ib/gal FIG)
0.13-0.5
(4 Ib/gal FIG)
0.25-0.5
(4 Ib/gal F1C)
0.5-0.63
(75% WP)
(4 Ib/gal F1C)
0.5-0.75
(4 Ib/gal F1C)
1
(75% WP)
0.75
(75% WP)
0.5-0.75
(4 Ib/gal F1C)
0.38-0.75
(4 Ib/gal F1C)
0.25-0.5
(4 Ib/gal F1C)
0.38-0.5
(4 Ib/gal FIG)
Tolerance, Use. Limitations
Use limited to silty clay to heavy clay soils of
the Mississippi Delta. Preemergence. Broadcast.
Plant seed 1.5 to 2 inches deep on flat or raised
seedbeds.
Tank mix with alachlor.
Use limited to the Southern States and Eastern
Coastal Plains. Preemergence. Broadcast.
Tank mix with pendimethalin.
Use limited to Northeastern and Northcentral
States. Preemergence. Broadcast.
Tank mix with pendimethalin.
Use limited to silty clay to heavy clay soils of
the Mississippi Delta. Preemergence. Broadcast.
Apply within 2 days after planting.
Tank mix with oryzalin.
Use limited to silty clay to heavy clay soils of
the Mississippi Delta. Preemergence. Broadcast.
Tank mix with chloramben.
Use limited to silty clay to heavy clay soils of
the Mississippi Delta. Preemergence. Broadcast
or band. May be preceded by a preplant soil in-
corporation of trifluralin; profluralin; pendi-
methalin; fluchloralin; or metolachlor.
Use limited to OH. Preemergence. Broadcast or
band. For use on medium and fine textured soils.
Tank mix with alachlor.
For use in minimum till or no-till soybeans.
Preemergence. Broadcast.
Tank mix with paraquat and glyphosate; or alachlor
and glyphosate.
For use in minimum till or no-till soybeans.
Preemergence. Broadcast. Apply with ground
equipment.
Tank mix with paraquat; paraquat and alachlor;
paraquat and oryzalin; or alachlor and glyphosate.
Issued: 11-01-83
1-101101-20
35
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(1,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
/25003AA
Site, Dosage
and Formulation
(Ib a.i./A)
Soybeans (continued)
0.5-0.75
(4 Ib/gal F1C)
0.25-0.5
(75% WP)
(4 Ib/gal F1C)
Sugarcane
2-4
(50% WP)
(70% WP)
(75% WP)
(4 Ib/gal F1C)
Tolerance, Use, Limitations
Use limited to silty clay to heavy clay soils of
the Mississippi Delta. For use in minimum till
or no-till soybeans. Preemergence. Broadcast.
Apply with ground equipment.
Tank mix with paraquat; paraquat and alachlor;
paraquat and oryzalin; or alachlor and glyphosate.
Use limited to the Southern and Southeastern
States (AL, AR, FL, GA, KY, CA, MS, MO, NC, OK,
SC, TN and TX). Postemergence. Directed spray.
Apply when soybeans are at least 8 to 12 inches
tall. Do not spray higher than 2 inches on soy-
bean stem. Apply with a nonionic surfactant. If
needed, a second application may be made after 7
days.
May be tank mixed with 2,4-DB.
0.1 ppm
0.3 ppm (molasses, processed feed)
0.5 ppm (bagasse, processed feed)
2 ppm (molasses, processed food)
Sixty day preharvest interval in FL, LA and TX.
Seventeen month preharvest interval in HI. Do
not use treated crop for feed or forage in FL, LA
and TX. Do not apply more than 8 Ib a.i./A per
crop cycle in HI.
General Information; Do not use on sugarcane
grown on sand in FL, LA and TX.
Use limited to HI. Preemergence or very early
postemergence. Broadcast. Apply within 2 weeks
after planting, prior to cane emergence or shortly
after emergence (spike stage).
OR
2-4
(50% WP)
(70% WP)
(75% WP)
(4 Ib/gal F1C)
Use limited to HI. Early postemergence. Broad-
cast. Apply over cane before weeds are 3 inches
tall. Application may be delayed 4 to 6 weeks
provided weeds are less than 3 inches tall.
OR
Issued: 11-01-83
1-101101-21
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-C1,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(AH)-ONE
Site, Dosage Tolerance, Use, Limitations
and Formulation
(Ib a.i./A)
Sugarcane (continued)
2-4
(50% WP)
(70% WP)
(75% WP)
(4 Ib/gal FIG)
4-6
(70% WP)
(75% WP)
(4 Ib/gal FIG)
4-6
(70% WP)
(75% WP)
(4 Ib/gal F1C)
2-4
(70% WP)
(4 Ib/gal F1C)
2.5-5
(50% WP)
(70% WP)
(75% WP)
(4 Ib/gal F1C)
1.5-3
(50% WP)
(75% WP)
(4 Ib/gal F1C)
1-2
(50% WP)
(75% WP)
(4 Ib/gal F1C)
Use limited to HI. Postemergence. Broadcast.
Apply prior to close-in and before weeds are 3
inches tall.
Use limited to HI. Preemergence. Aerial appli-
cation. Apply to irrigated cane within 2 weeks
after planting.
OR
Use limited to HI. Early postemergence. Aerial
application. Apply over irrigated cane before
weeds are 3 inches tall. Application may be de-
layed 4 to 6 weeks provided weeds are less than 3
inches tall.
OR
Use limited to HI. Postemergence. Aerial appli-
cation. Apply to irrigated cane prior to close-in
and before weeds are 3 Inches tall.
Use limited to HI. Spot treatment. Dilute the
product in sufficient water to prepare 30 to 50
gallons of finished spray, and spot spray on
missed areas or hard to control weeds.
Use limited to LA and IX. Preemergence or post-
harvest. Broadcast. Apply in the fall after
planting but before cane emergence, or to the
stubble after harvest. Make a second application
in early spring prior to new cane growth. If
necessary, a third application may be made in the
late spring at layby.
Use limited to FL. Postemergence. Directed
spray. Apply after sugarcane is 12 inches tall
but before row crossing. Do not apply more than
2 Ib a.i./A per crop season.
Issued: 11-01-83
1-101101-22
37
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-S(4H)-ONE
/11005AA
Site, Dosage
and Formulation
(Ib a.i./A)
Tomato
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal FIG)
Tolerance, Use, Limitations
0.1 ppm
2 ppm (dried tomato pomace, processed feed)
Seven day preharvest interval. Do not forage or
feed treated foliage to livestock. Do not apply
more than 1 Ib a.i./A within a 35 day period per
crop season except in the case of directed sprays.
General Information; Do not treat seeded or
transplanted tomatoes until plants have reached
the 5- to 6-leaf stage, or until transplants have
recovered from transplant shock and new growth
has started. Apply only if there have been at
least 3 successive days of sunny weather prior to
application, or crop injury may occur when apply-
ing postemergent. Do not apply within 24 hours
of treatment with other pesticides. When applying
postemergent to established tomatoes, do not tank
mix with other pesticides. Tomato varieties vary
in their resistance to metribuzin; therefore, de-
termine varietal tolerance prior to large scale
use. Do not use hot caps within 7 days before or
at any time after application. Directed sprays
should be used in fields with severe weed pressure
or in fields with hard to control weeds. Do not
apply to soils containing a calcareous surface
layer or a pH of 7.5 or higher. Allow a minimum
of 14 days between applications. Do not apply
within 14 days of transplanting.
Use limited to areas east of the Rocky Mountains
(except FL). Pretransplant. Broadcast. Incor-
porate to a depth of 2 to 4 inches. Use the
higher dosage for heavy weed pressure or hard-to-
control weeds.
May be tank mixed with trifluralin.
Use limited to areas other than CA. Pretrans-
plant. Broadcast. Incorporate to a depth of 2
to 4 inches.
May be tank mixed with trifluralin.
Use limited to areas east of the Rocky Mountains
(except FL). Postemergence. Broadcast. For use
on established tomatoes. Make 1 or more applica-
tions per crop season. Use the higher dosage for
heavy weed pressure or hard-to-control weeds.
Issued: 11-01-83
1-101101-23
38
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(1,1-DIMETHYLETHYL)-3-(METHYLTHIO)-1,2,4-TRIAZIN-5(4H)-ONE
Site, Dosage Tolerance, Use, Limitations
and Formulation
(Ib a.i./A)
Tomato (continued)
0.5-1
(50% WP)
(75% WP)
(4 Ib/gal FIG)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.38
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.5-1
(50% WP)
(75% WP)
(4 Ib/gal F1C)
Use limited to areas east of the Rocky Mountains
(except FL). Postemergence. Directed spray. Do
not allow spray to contact tomato foliage. For
use on established tomatoes. Make 1 or more ap-
plications per crop season. Use the higher dosage
for heavy weed pressure or hard-to-control weeds.
Use limited to areas other than FL. Postemer-
gence. Broadcast. Apply to established tomatoes
as a single or split application. For split ap-
plications, apply 0.25 to 0.38 Ib a.i./A per ap-
plication. Do not exceed 2 treatments per crop
season.
Postemergence. Broadcast. For use on established
tomatoes. Make 1 or more applications per crop
season. Use the higher dosage for heavy weed
pressure or hard-to-control weeds.
Postemergence. Directed spray. Do not allow
spray to contact tomato foliage. For use on es-
tablished tomatoes. Make 1 or more applications
per crop season. Use the higher dosage for heavy
weeds pressure or hard-to-control weeds.
Issued: 11-01-83
1-101101-24
39
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(1,1-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
/28065AA
Site, Dosage
and Formulation
(Ib a.i./A)
Wheat
(dryland winter)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal FIG)
Tolerance, Use. Limitations
0.75 ppm (grain)
1 ppm (straw)
2 ppm (forage)
3 ppm (milled fractions (except flour) of
processed food and feed)
Do not graze treated fields for 14 days following
application. Do not graze treated fields after a
fallow application*
General Information; Do not apply more than once
per crop. Do not use on any soils containing
less than 1 percent organic matter. Do not use
on irrigated wheat or crop injury may occur.
Temporary chlorosis may occur after application
especially if frost occurs. Not recommended for
use if soils are high in lime or sodium or have a
pH greater than 7.7. Crop injury may occur if
secondary roots have not developed at time of ap-
plication.
Do not plant spring seeded cereals following fall
fallow applications. Do not apply in the spring
if an application was made in the fall. Do not
use on the winter wheat varieties Morex, Glenn or
Morvain 3.
Use limited to areas east of the Cascades in ID,
OR, UT and WA on varieties Daws, Gaines, Hyslop,
Luke, McDermid, Moro, Nugaines, Paha, Peck,
Stevens and Wanser, and in MT on the varieties
Centurk, Cheyenne and Winalta. Postemergence.
Broadcast. Apply after wheat has fully tillered
and developed secondary roots, but before joint-
ing. Do not use on any soils containing less
than 1 percent organic matter. Do not use if
soils are high in lime or sodium or have a pH
greater than 7.7. Temporary chlorosis may occur,
especially if the crop is under stress or if ap-
plication is made in fluid fertilizers.
May be tank mixed with dicamba, dimethylamine
salt; 2,4-D; terbutryn; or bromoxynil and MCPA.
Issued: 11-01-83
1-101101-25
40
-------
r.rA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Site, Dosage Tolerance, Use, Limitations
and Formulation
(Ib a.i./A)
Wheat (continued)
0.19-0.25
(75% WP)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.75
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.25-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.34-0.75
(4 Ib/gal F1C)
Use limited to areas east of the Cascades in ID,
OR, UT and WA on varieties Daws, Gaines, Hyslop,
Luke, McDermid, Moro, Nugaines, Paha, Peck,
Stevens and Wanser, and in MT on the varieties
Centurk, Cheyenne and Winalta. Postemergence.
Broadcast. Broadleaf weed control. Apply only
in the spring after wheat has started to grow and
has a well established secondary root system with
at least 3 to 4 tillers.
Tank mix with bromoxynil; or bromoxynil and MCPA.
Use limited to KS, OK and TX on the varieties Tarn
W101, Tarn 105, and Newton. Postemergence.
Broadcast. Apply in the fall after wheat has a
minimum of 3 tillers and 4 secondary roots at
least 2 inches in length, but before winter dor-
mancy .
May be tank mixed with dicamba, dimethylamine
salt; 2,4-D; bromoxynil; or bromoxynil and MCPA.
Use limited to KS, OK and TX on the varieties Tarn
W101, Tarn 105, and Newton. Postemergence.
Broadcast. Apply in the spring after wheat has
fully tillered and has developed secondary roots
at least 2 inches in length.
May be tank mixed with dicamba, dimethylamine
salt; 2,4-D; bromoxynil; or bromoxynil and MCPA.
Use limited to KS, OK and TX. Postemergence.
Broadcast. Apply prior to jointing when crop is
well tillered (at least 3 tillers) and has devel-
oped 2 inch secondary roots throughout the field.
Do not use on coarse textured soils with less
than 2 percent organic matter.
May be tank mixed with dicamba, dimethylamine
salt; 2,4-D; bromoxynil; terbutryn; chlorsulfuron;
or bromoxynil and MCPA.
Postharvest. Broadcast. For use on fallow land
to be planted to winter wheat. Apply after weed
emergence.
Tank mix with propham; paraquat; glyphosate; or
chlorsulfuron if large weeds are present.
Issued: 11-01-83
1-101101-26
41
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-C1,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Site, Dosage Tolerance, Use, Limitations
and Formulation
(Ib a.i./A)
Wheat (continued)
0.5-0.75
(4 Ib/gal FIG)
0.34-0.5
(4 Ib/gal FIG)
0.63-0.75
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.38-0.5
(50% WP)
(75% WP)
(4 Ib/gal FIG)
(wheat, fallow)
0.5-0.63
(50% WP)
(75% WP)
(4 Ib/gal F1C)
0.38-0.5
(50% WP)
(75% WP)
(4 Ib/gal F1C)
Use limited to CO, ID, KS, MT, NE, ND, OK, OR,
SD, TX, UT and WA. Postharvest. Broadcast.
Apply to actively growing weeds in fall fallow.
Tank mix with propham; paraquat; glyphosate; or
chlorsulfuron if large weeds are present.
Use limited to CO, ID, KS, MT, NE, ND, OK, OR,
SD, TX, UT and WA. Postharvest. Broadcast.
Apply to actively growing weeds in spring fallow.
Tank mix with propham; paraquat; glyphosate; or
chlorsulfuron if large weeds are present.
Use limited to CO, KS, MT, NE and WY. Postharvest
application in fall fallow. Broadcast, apply
prior to weed emergence. Do not plant crops in
treated areas earlier than 10 months following
fall applications. Do not make another applica-
tion in the spring.
Tank mix with paraquat; glyphosate or other con-
tact herbicide if weed growth is present.
Use limited to CO, KS, MT, NE and WY. Spring ap-
plication in summer fallow. Broadcast. Apply
prior to weed emergence. Wheat can be seeded 120
days after spring application.
Tank mix with paraquat; glyphosate or other con-
tact herbicide if weed growth is present.
Use limited to ID, OR, UT and WA. Postharvest
application in fall fallow. Broadcast. Apply
prior to weed emergence. Do not plant crops in
treated areas earlier than 10 months following
fall applications.
May be tank mixed with propham.
Tank mix with paraquat or other contact herbicide
if weed growth is present.
Use limited to ID, OR, UT and WA. Spring appli-
cation in summer fallow. Broadcast. Apply prior
to weed emergence. Wheat can be seeded 120 days
after spring application.
May be tank mixed with propham after January 1
and before March 1.
Issued: 11-01-83
1-101101-27
4?
-------
/33017AA
/670000A
/670050A
EPA Index to Pesticide Chemicals
4-AMINO-6-(1,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-S(4H)-ONE
Site, Dosage Tolerance, Use, Limitations
and Formulation
(Ib a.i./A)
TERRESTRIAL NON-FOOD CROP
(Ornamental Plants and Forest Trees)
Bermudagrass
0.5
(50% WP)
(75% WP)
0.25-0.5
(50% WP)
(75% WP)
General Information; For use on established com-
mon bermudagrass growing on golf course fairways
and commercial sod farms. Apply in 40 gallons of
water per acre. Do not apply more than 1.5 Ib
a.i./A in a single growing season. Do not apply
more than once to dormant turf, or more than twice
to actively growing turf in a single growing sea-
son. Do not apply to greens, tees, aprons or
other closely mowed turf. Do not mow for 3 days
following treatment for maximum weed control.
Use limited to AL, AR, FL, GA, LA, MS,. NC, SC,
IN, TX and VA. Broadcast. Apply to actively
growing weeds in dormant turf prior to green up.
Use limited to AL, AR, FL, 6A, LA, MS, NC, SC,
TN, TX and VA. Broadcast. Apply to actively
growing turf. Repeat application if necessary,
with a minimum of 1 week between applications.
Temporary discoloration may occur.
(Noncrop, Wide Area, and General Outdoor Treatments)
Noncrop Areas
1-6
(50% WP)
(75% WP)
(4 Ib/gal FIG)
Railroad Rights-of-
Way
6-7.5
(75% WP)
Broadcast. Apply to emerged weeds.
May be tank mixed with paraquat or glyphosatei
Broadcast. Apply to bare soil.
Issued: 11-01-83
1-101101-28
43
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-U, l-DIMETHYLETHYL)-3-(METHYLTHIO)-l ,2,4-TRIAZIN-S (4H)-ONE
Site, Dosage Tolerance, Use, Limitations
and Formulation
(Ib a.i./A)
AERIAL AND TANK MIX APPLICATIONS
9001500
AAAAAAA
Aerial Application
9900300
AAAAAAA
Tank Mix
Refer to
TERRESTRIAL FOOD CROP
(Agricultural Crops)
Alfalfa, Asparagus, Barley, Corn, Corn (Field),
Potato, Sainfoin, Soybeans, Sugarcane, Wheat
Refer to
TERRESTRIAL FOOD CROP
(Agricultural Crops)
Barley, Corn, Corn (Field), Potato, Soybeans,
Tomato, Wheat
TERRESTRIAL NON-FOOD CROP
(Noncrop, Wide Area, and General Outdoor
Treatments) ~~
Noncrop Areas
Issued: 11-01-83
1-101101-29
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-C1,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Listing of Registered Pesticide Products by Site and Formulation
&050.0002 50% formulation intermediate
4-amino-6-(l,l-dimethylethyl)-3-(methylthio)-l,2,4-triazin-
5(4H)-one (101101)
003125-00305
&050.0006 50% wettable powder
4-andno-6-(l,l-dimethylethyl)-3-(methylthio)-l,2,4-triazin-
5(4H)-one (101101)
000352-00375 003125-00277 039926-00002
&070.0006 70% wettable powder
4-amino-6-(l,l-dimethylethyl)-3-(methylthio)-l,2,4-triazin-
5(4H)-one (101101)
003125-00294
&075.0006 75% wettable powder
4-amino-6-(l,l-dimethylethyl)-3-(methylthio)-l,2,4-triazin-
5(4H)-one (101101)
000352-00390 000352-00407 003125-00325
&104.0014 4 Ib/gal flovable concentrate
4-amino-6-(l,l-dimethylethyl)-3-(methylthio)-l,2,4-triazin-
5(4H)-one (101101)
000352-00382 003125-00314 039926-00001
9999999 State Label Registration
LA Reg. No.
037820-08433
Issued: 11-01-83
1-101101-30
45
-------
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Appendix A
Common Chemical Names Used on the Entry
Listing of
Chemical
Code
030001
030501
030703
030801
047601
061601
100101
103601
118601
Common Name
(source)
2,4-D
MCPA
sodium naptalam
2,4-DB
propham
paraquat
bladex
glyphosate
chlorsulfuron
EPA Acceptable
Common/Chemical Name
2,4-dichlorophenoxyacetic acid
2-methyl-4-chlorophenoxyacetic acid
N-1-naphthylphthalamic acid, sodium
salt
4-(2,4-dichlorophenoxy)butyric acid
isopropyl carbanilate
paraquat dichloride
2-[[4-chloro-6-(ethylamino)-5-triazin-
2-yl]amino]-2-methyl propionitrile
glyphosate, isopropylamine salt
2-chloro-N-[((4-methoxy-6-methyl-l,3,5-
trlazin-2-yl)amino)carbonyl]benzenesulf-
onamide
Issued: 11-01-83
1-101101-31
46
-------
/28069AA
/16002AA
/28063AA
/28005AA
/28006AA
EPA Index to Pesticide Chemicals
4-AMINO-6-U,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-S(4H)-ONE
Appendix B
Listing of Registration Numbers by Site and Formulation
TERRESTRIAL FOOD CROP
(Agricultural Crops)
Alfalfa
I
003125-00277
(50% WP)
000352-00375
(75% WP)
000352-00390
003125-00325
(4 Ib/gal F1C)
000352-00382 003125-00314
Asparagus
(50% WP)
000352-00375
(75% WP)
000352-00390
(4 Ib/gal FIG)
003125-00314
Barley
(50% WP)
000352-00375
(75% WP)
000352-00390
003125-00277
003125-00325
003125-00325
(4 Ib/gal F1C)
000352-00382 003125-00314
Corn
T30T WP)
003125-00277
Corn, Field
(75% WP)
003125-00325
(4 Ib/gal F1C)
003125-00314
Issued: 11-01-83
1-101101-32
47
-------
/14013AA
/28077AA
/15010AA
/25003AA
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Appendix B
Listing of Registration Numbers by Site and Formulation (continued)
Potato
>)
039926-00002
(50% WP)
000352-00375
(75% WP)
000352-00390
(4 Ib/gal F1C)
000352-00382
Sainfoin
(50% WP)
000352-00375
(75% WP)
000352-00390
(4 Ib/gal FIG)
000352-00382
Soybeans
(50% WP)
000352-00375
(75% WP)
000352-00390
(4 Ib/gal F1C)
000352-00382
Sugarcane
(50% WP)
000352-00375
(70% WP)
003125-00294
(75% WP)
000352-00390
(4 Ib/gal F1C)
000352-00382
003125-00277
003125-00325
003125-00314
003125-00277
003125-00325
003125-00314
003125-00277
003125-00325
003125-00314
003125-00277
003125-00325
003125-00314
039926-00001
039926-00002
039926-00001
Issued: 11-01-83
1-101101-33
48
-------
/11005AA
/28065AA
EPA Index to Pesticide Chemicals
4-AMINO-6-(l,l-DIMETHYLETHYL)-3-(METHYLTHIO)-l,2,4-TRIAZIN-5(4H)-ONE
Appendix B
Listing of Registration Numbers by Site and Formulation (continued)
Tomato
>)
003125-00277
(50% WP)
000352-00375
(75% WP)
000352-00390
(4 Ib/gal F1C)
000352-00382
Wheat
003125-00325
003125-00314
(dryland winter)
(50% WP)
000352-00375
(75% WP)
000352-00390
(4 Ib/gal F1C)
000352-00382
003125-00325
003125-00314
(wheat, fallow)
(50% WP)
000352-00375
(75% WP)
000352-00390
(4 Ib/gal FIG)
000352-00382
003125-00325
003125-00314
TERRESTRIAL NON-FOOD CROP
(Ornamental Plants and Forest Trees)
/33017AA Bermudagrass
(50% WP)
003125-00277
(75% WP)
003125-00325
Issued: 11-01-83
1-101101-34
49
-------
EPA Index to Pesticide Chemicals
4- AMINO-6-(1,1-DIMETHYLETHYL)-3-(METHYLTHIO)-1,2,4-TRIAZIN-5(4H)-ONE
Appendix B
Listing of Registration Numbers by Site and Formulation (continued)
(Noncrop, Wide Area, and General Outdoor Treatments)
/670000A Noncrop Areas
(50% WP)
000352-00375
(75% WP)
000352-00390
(4 Ib/gal F1C)
000352-00382
/670050A Railroad Rights-of-
Way
(75% WP)
000352-00407
Issued: 11-01-83
1-101101-35
50
-------
REQUIREMENT FOR SUBMISSION OF GENERIC DATA
A. This portion of the guidance document is a Notice
issued under the authority of PIPRA sec. 3(c)(2)(B). The
tables following this section list the data required for
maintaining the registrability of each product.
EPA has determined that additional generic data described
in Table A must be submitted to EPA for evaluation in order
to maintain in effect the registration(s) of your product(s)
identified as an attachment to the cover letter accompanying
this guidance document. As required by PIPRA sec. 3(c)(2)(B),
you are required to take appropriate steps to comply with
this Notice.
EPA may suspend the registration of each of those products
unless, within the specified time, you have informed EPA how
you will satisfy the requirements of this Notice. Any such
suspension will remain in effect until you have complied with
the terms of this Notice.
B. What Generic Data1/ Must be Submitted. You may deter-
mine which generic data you must submit by consulting Table A
at the end of this chapter. That table lists the generic
data needed to evaluate the continued registrability of all
products, and the dates by which the data must be submitted.
The required studies must be conducted in accordance with
EPA approved protocols (such as those contained in the Pesticide
Assessment Guidelines £/ or data collected under the approved
protocols of the Organization for Economic Cooperation and
Development (OECD). If you do not wish to develop data
in support of certain uses appearing in your labeling, you
may delete those uses at the time you submit your revised
labeling.
For certain kinds of testing (generally ecological
effects), EPA requires the test substance to be a "typical
formulation," and in those cases EPA needs data of that type
I/ Generic data pertain to the properties or effects of a
particular Ingredient, and thus are relevant to an evaluation of
the risks of all products containing that ingredient, regardless
of the product's unique composition or specific use. Product-
specific data relate only to the properties or effects of a
product with a particular composition (or a group of products
with closely similar composition).
£/ The Pesticide Assessment Guidelines are available in hard
copy or microfiche from the National Technical Information
Service, 5285 Port Royal Road, Springfield, Va. 22161.
51
-------
for each major formulation category (e.g., emulsifiable concen-
trates, wettable powders, granulars, etc.) These are classified
as generic data and when needed are specified in Table A.
EPA may possess data on certain "typical formulations" but
not others. Note; "Typical formulation" data should not be
confused with product-specific data (Table B) which are
required on each formulation. Product-specific data are
further explained in Chapter III of this document.
C. Options Available for Complying With Requirements
to Submit Data
Within 90 days of your receipt of this Notice you must
submit to EPA a completed copy of the form entitled "PIPRA
Section 3(c)(2)(B) Summary Sheet" [EPA Form 8580-1, Appendix
II-3] for each of your products. On that form you must state
which of the following methods you will use to comply with
the requirements of this Notice:
1. (a) Notify EPA that you will submit the data, and
(b) either submit the existing data you believe will
satisfy the requirement, or state that you will generate
the data by conducting testing. If the test procedures
you will use deviate from (or are not specified in) the
Pesticide Assessment Guidelines or protocols contained in
the Reports of Expert Groups to the Chemicals Group,
Organization for Economic Cooperation and Development
(OECD) Chemicals Testing Programme, you must enclose the
protocols you will use.
OR
2. Notify EPA that you have entered into an agreement
with one or more other registrants to Jointly develop (or
share in the cost of developing) the data. If you elect
this option, you must notify EPA which registrant(s) are
parties to the agreement.
OR
3. Pile with EPA a completed "Certification of Attempt to
Enter Into an Agreement With Other Registrants for Develop-
ment of Data" (EPA Form 8580-6, Appendix II-4)*/
V PIFRA sec. 3(c)(2)(B) authorizes Joint development of
data by two or more registrants, and provides a mechanism by
which parties can obtain an arbitrator's decision if they agree
to Jointly develop data but fail to agree on all the terms of
the agreement. The statute does not compel any registrant to
agree to develop data Jointly.
(Footnote continued on next page)
-------
OR
4. Request that EPA amend your registration by deleting
the uses for which the data are needed. (This option Is
not available to applicants for new products.)
OR
5* Request voluntary cancellation of the reglstratlon(s)
of your products for which the data are needed. (This option
is not available to applicants for new products.)
D. Procedures for Requesting Changes in Testing Methodology
and Extensions of Time
EPA recognizes that you may disagree with our conclusions
regarding the appropriate ways to develop the required data
or how quickly the data must be submitted. If the test
procedures you plan to use deviate from (or are not specified
in) the registration guidelines or protocols contained in
the reports of the Expert Groups to the Chemical Groups,
Organization for Economic Cooperation and Development (OECD)
Chemicals Testing Programme, you must submit the protocol
for Agency review prior to the initiation of the test.
If you think that you will need more time to generate the
required data than Is allowed by EPA's schedule, you may
submit a request for an extension of time. The extension
request must be submitted in writing to the Product Manager.
(Footnote continued from previous page)
In EPA's opinion, Joint data development by all regis-
trants subject to a data requirement or a cost-sharing agreement
among all such registrants Is clearly in the public Interest.
Duplication of testing could increase costs, tie up testing
facilities, and subject an unnecessarily large number of
animals to testing.
As noted earlier, EPA has discretion to suspend the
registration of a product when a registrant falls to submit data
required under FIFRA Section 3(c)(2)(B). EPA has concluded that
it should encourage Joint testing rather than duplicatlve
testing, and that suspension should be withheld in certain cases.
to further this goal. Accordingly, if (1) a registrant has
informed us of his intent to develop and submit data required
by this Notice; and (2) a second registrant informs EPA that
it has made a bona fide offer to the first registrant to share
in the expenses of the testing [on terms to be agreed upon
or determined by arbitration under FIFRA Section 3(c)(2)(B)(ill)];
and (3) the first registrant has declined to agree to enter
into a cost-sharing agreement, EPA will not suspend the
second firm's registration.
53
-------
The extension request should state the reasons why you believe
that an extension is appropriate. While EPA considers your
request, you must strive to meet the deadline for submitting
the required data.
54
-------
III. REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA
Note: Unless stated otherwise in Section I, Regulatory
Position and Rationale, this Section applies only to manufac-
turing use products, not to end use products.
A necessary first step in determining which statements
must appear on your product's label is the completion and
submission to EPA of product-specific data* listed on the
form entitled "Product Specific Data Report" (EPA Form
8580-4, Appendix III-l) to fill gaps identified by EPA
concerning your product. Under the authority of PIPRA sec.
3(c)(2)(B), EPA has determined that you must submit these
data to EPA in order to reregister your product(s). All of
these data must be submitted not later than six months after
you receive this guidance document.
Table B—Product-Specific Data Requirements for Manufacturing
Use Products—lists the product specific data you must submit.
Data that are required to be submitted are identified in the
column of those tables entitled "Must Data By Submitted
Under §3(c)(2)(B)."
V Product specific data pertain to data that support the
formulation which is marketed; it usually includes product
chemistry data and acute toxicity data.
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Guideline Citation and
Name of Test
§158.120 Product Chemistry
Product Identity:
61-2 - Product Identity and Disclosure
of Ingredients
61 -3- Discussion of Formation of
Impurities
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical State
63-4 - Odor
63-5 - Melting Point
63-6 - Boiling Point
63-7 - Density, Bulk Density, or
Test Guidelines
Substance Status
TGAI R
TGAI R
TGAI CR
TGAI R
TGAI R
TGAI R
TGAI R
TGAI R
TGAI R
Are Data
Required
Yes
[X]
[XI
[X]
M
n
[X]
[X]
n
[X]
. Data Must Be
Footnote Submitted Within
Number Timeframes Liste<
No Below \J
M 6 Months
M 2 6 Months
M 3 12 Months
tx]
[XI
[ ] 6 Months
[ ] 6 Months
[X]
M 4 6 Months
Specific Gravity
63-8 - Solubility
TGAI or PAI
[X]
6 Months
56
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Guideline Citation and
Name of Test
Test
Substance
Guidelines
Status
Are Data
Required
Yes No
Footnote
Number
Data Must Be
Submitted Within
Timeframes Listed
Below V
§158.120 Product Chemistry (Continued)
Physical and Chemical Characteristics
(Continued)
63-9 - Vapor Pressure PAI
63-10 - Dissociation constant PAI
63-11 - Octanol/water partition PAI
coefficient
63-12 - pH TGAI
63-13 - Stability TGAI
Other Requirements;
64-1 - Submittal of samples TGAI, PAI
R
R
R
R
R
CR
[JF]
[XI
IX)
[X]
[X]
[J
[J
[J
Q
tx]
6 Months
6 Months
6 Months
6 Months
TGAI = Technical Grade of the Active Ingredient; PAI = Pure Active Ingredient; R = Required; CR = Conditionally Required
1/ Data must be submitted within the indicated time frame, based on the date of the Guidance Document.
~ ° 6 Month Due Date is December 31 , 1985 _ .
0 12 Month Due Date is June 30, 1985 _ .
2/ A discussion of each impurity believed to be present at >0.1% based on knowledge of beginning materials, all possible
chemical reactions and any contamination.
3/ Five or more representative samples should be analyzed for the amount of active ingredient and each impurity present
~ for which a certified limit is required.
4/ The temperature at which the determination is made must be submitted.
5/ The solubility must be determined at 20 or 25° in distilled water and in representative polar and non- polar solvents.
"e/ Information must be provided as to sensitivity to sunlight, metals and metal ions as well as temperature and pH.
57
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Data Requirements
Composition1 /
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Timeframes For Data
Submission2/
$158.125 Residue Chemistry
171-2 - Chemical Identity
TGAI
171-3 - Directions for Use
171-4 - Nature of Residue (Metabolism)
- Plants PAIRA
Partially
Yes
Partially
- Livestock
171-4 - Residue Analytical Method
- Plant residues
PAIRA and Plant
Metabolites
TGAI and Metabolites
Partially
Yes
00056362 00106207
00093409
Yes 6 Months
No
00024737 00045278 Yes 24 Months4/^/
00036112 00045279
00036219 00045280
00036220 00106168
00045257 00106189
00045258 00106199
00045260 00106189
00045275 GS0181-003
00036105 00045263
00036106 00045262
00036107 00106164
00015412
00015414
00029800
00036427
00032428
00032429
00036216
00036432
00036433
00087926
00106163
00106164
00106165
00106168
00106169
00106173
00106179
00106180
Yes 18 Months6/7/
No8/
58
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Data Requirements
Compos! tionV
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA $ 3(c)(2)(B)7
Timeframes For Data
Submission2-/
$158.125 Residue Chemistry - Continued
- Animal residues
171-4 - Storage Stability
TGAI and Metabolites Yes
PAI
Yes
171-4 - Magnitude of the Residue-
Residue Studies for each
food use
- Root and Tuber Vegetables GroupV
- Potatoes TEP
Yes
59
00036776
00036782
00039530
00045256
00054354
00054369
00069067
00087925
00106182
00106183
00106185
00106193
00106199
00106203
00106205
00106211
GS0181-006
GS0181-007
00036431 GS0181 -004 No
00045282 GS0181-005
00036441 00054358
00036777 00054360
00036778 00054363
00054355 00054366
00054356 GS0181-002
00039525 00078436
00106199 00078438
00106203 00105212
00026411 00106191
00039531 00106797
No
No
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBOZIN
Data Requirements
Composition1/
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Bibliographic
Citation
Most Additional Data
Be Submitted Under
FIFRA I 3(c)(2)(B)?
Timeframes For Data
Submission?/
$158
.125 Residue Chemistry - Continued
- Potato Chips EP
- Processed potato waste EP
Legume Vegetables Group1 O/
- Lentils TEP
- Peas (dried and succulent) TEP
- Soybeans TEP
Yes
Yes
Yes
Partially
Partially
00036110
00026612
000361 1 0
000361 1 2
001 061 79
00106179
0001 5773 001 01 537
No
No
No
Yes 24 Months11/
Yes 24 Months12/
Foliage of Legume Vegetables Group1V
Lentil forage and hay TEP
Peas vines and straw TEP
Soybean forage, hay and straw TEP
Fruiting Vegetables (Except Cucurbits) Group17/
Tomatoes TEP
Yes14/
Yes15/
Partially16/
Yes
6,0
00024503 001O6215
00064797 6SO181-003
OO106179
OO106179
OOO15773 OOO87925
00015949 00101537
00067433 00106183
00086681 00106215
00106180
00106212
No
No
Yes 24 Months
No
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHEMICAL: METRIBDZIN
Data Requirements
Composition1/
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Older
FIFRA § 3(c)(2)(B)?
Timeframes For Data
Submission?/
§158.125 Residue Chemistry - Continued
Tomato products (catsup puree) EP
Cereal Grains Group19/
Barley
Barley milling fractions
Corn grain (including popcorn
and fresh)
Fresh corn canning waste
Wheat
Wheat milled fractions
Yes
TEP
EP
TEP
EP
TEP
Yes
Partially
Partially
Yes
Yes
EP
Partially
61
001 061 80
06106212
00036428 00106185
00036444 00106182
00087926
00036428 00106185
00036444 00106182
00087926
00036429 00078942
00036443 00078943
001 061 73
00036429 00078942
00036443 00078943
001 061 73
00036426 00087926
00036435 00106173
00036439 00106182
00036445 00106184
00067425 00106185
00036426 00087926
00036435 00106173
00036439 00106182
00036445 00106184
00067425 00106185
No
Yes21/ 24 Months
No
Yes^3/ 24 Months
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Data Requirements
Compos! tion_V
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Timeframes For Data
Submission?/
158.125 Residue Chemistry - Continued
Forage, Fodder, Hay and Straw of Cereal Grains Group24/
Barley forage, hay and straw TEP
Corn forage, silage and fodder
TEP
Partially
Partially
Wheat forage, hay and straw
TEP
Partially
Grass Forage, Fodder and Hay Group28/
Grass forage and hay TEP
Non-grass Animal Feed Group29/
Alfalfa forage, hay and seed
Yes
Sainfoin forage and hay
TEP
TEP
Partially
Yes
00036434 00087926
00036440 00106185
00045255 00106182
00036429
00036443
00078942
00078943
00106173
00036426 00087926
00036435 00106173
00036439 00106182
00036445 00106185
00067425
00036438
00036770
00036780
00036437 00106182
00036769 00106185
00036779
00036436
00036781
Yes 24 Months26/
Yes 24 Months27/
Yes 24 Months£/2°_
No
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Data Requirements
Compos!tionj/
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)7
Timeframes For Data
Submission?/
§158.125 Residue Chemistry - Continued
Miscellaneous Commodities
Asparagus TEP
- Sugarcane TEP
Sugarcane forage TEP
Sugarcane bagasse, molasses, EP
refined sugar
1 71 -4 Magnitude of the Residues in
Meat, Milk, Poultry and Eggs
Milk TGAI or Plant
Metabolites
Meat, fat and meat byproducts TGAI or Plant
of cattle, goats, hogs, horses Metabolites
and sheep
Poultry and Eggs TGAI or Plant
Metabolites
Yes 00037841
00106173
00106211
Yes 00106168
001 061 90
00106202
No
Partially 00106168
00106190
001 06202
Partially 00036772
00106199
Partially
00045283
Partially 00045284
00045286
No3/31 j
No
Yes 24 Months32/
Yes 24 Months3/33
Reserved34/
Reserved34/
Reserved34/
63
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
[58.125 Residue Chemistry - Continued
_1_/ Composition: TGAI = Technical grade of the active ingredient; PAIRA = Pure active ingredient, radiolabeled;
TEP = Typical end-use product; EP = End-use product.
2/ Data must be submitted within the indicated time frame, based on the date of the Guidance Document.
0 6 Month Due Date is December 31 , 1985 .
0 1 8 Month Due Date is December 31 , 1986 .
0 24 Month Due Date is June 30, 1987 .
3/ Includes filing fee (establishing or changing a tolerance(s) requires a fee).
4/ Data reflecting the distribution and metabolism of ring-labeled [14C] metribuzin in mature soybeans (foliage and
beans) following preemergent soil application at 0.5 Ib ai/A. Analysis should include hydrolysis and reextraction of
plant residues and aqueous fractions to determine conjugated 14C residues of metribuzin.
_5/ Data reflecting the distribution and metabolism of ring-labeled [14C] metribuzin in mature wheat (foliage and grain)
following postemergence broadcast application at 0.75 Ib ai/A. Analysis should include hydrolysis and reextraction of
plant residues and aqueous fractions to determine conjugated 14C-residues of metribuzin.
6/ Metabolism studies are required utilizing ruminants. Animals must be dosed for 3 days with ring-labeled [14C]
metribuzin at a level sufficient to make residue identification possible. Milk must be collected twice daily during
the dosing period. Animals must be sacrificed within 24 hours of the final dose. This distribution and characterization
of residues (free and conjugated) must be determined in milk, liver, kidney, muscle and fat.
7/ Metabolism studies are required utilizing poultry. Hens must be dosed with ring labeled [14C] metribuzin for 3 days
at a level sufficient to permit residue identification. Eggs must be collected twice daily during the dosing period.
Animals must be sacrificed within 24 hours of the final dose and residues characterized in eggs, muscle, liver, kidney
and fat.
8/ The conclusions stated here are tentative. Should the data requested in the "Nature of Residues in Plants" and "Nature
of Residue in Animals" indicate additional metabolites of toxicological concern or that the methods do not adequately
determine all conjugated residues of concern then submission of additional validated methods for data collection and
tolerance enforcement will be required.
9/ A crop group tolerance is not appropriate at this time for the following reason: Residue data are required for two
additional members of this group (radish and sugar beet), currently a tolerance exists for residues in or on potatoes
only. The available data in support of a proposed tolerance for metribuzin residues in or on carrots are currently
under review.
10/ A crop group tolerance is not appropriate at the present time for the following reasons:
a. Additional data are needed to support the established tolerances for residues in or on soybeans and dried peas.
b. Residue data are needed for one additional member of this crop group (succulent beans); presently, metribuzin is
registered for use on lentils, peas, and soybeans.
64
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
§158.125 Residue Chemistry - Continued
11 / Data is required deplicting combined residues of metribuzin, DADK, DA, and DK in or on dried pea seed 50 days after
postemergence application of the 50% WP formulation at 0.38 Ibs ai/A. Test must be conducted in the Northvest.
12/ Data reflecting residues in or on soybeans harvested at normal maturity following two postemergence applications
made at 7-day intervals of the 75% WP or 4 Ib/gallon FLC formulation at 0.5 Ibs ai/A application which were
preceded by a preemergence application at 1 Ib ai/A and a preplant application at 0.75 Ib ai/A. Tests must be
conducted in the MS delta region.
13/ A crop group tolerance is not appropriate at this time for the following reasons:
a. Additional data are required to support the established tolerances for residues in soybean forage and hay.
b. Pregrazing intervals must be proposed for lentil forage and pea vines.
c. The established tolerances for residues in or on pea and lentil forage (0.5 ppm) and in or on soybean forage
(4 ppm) differ by more than a factor of five. Also, the established tolerances for residues in or on pea
and lentil vine hay (0.05 ppm) and soybean hay (4 ppm) differ by more than a factor of five.
14/ The data to support the tolerances for lentil hay are adequate. The data to support tolerances for lentil forage
will be adequate provided a pregrazing interval of 40 days is proposed for lentil forage.
15/ The data to support the tolerances for lentil hay and forage are translatable to support the tolerances for pea vines
and straw. The data is adequate to support these tolerances provided a pregrazing interval of 40 days is proposed.
16/ Data reflecting combined residues of metribuzin, DADK, DA, and DK in or on soybean forage and hay harvested 40 days
after the last of two postemergence applications of a WP or 4 Ib/gal FLC formulation at 0.5 Ib ai/A preceded by a
preemergence application at 1 Ib ai/A and a preplant application at 0.75 Ib ai/A. Tests must be conducted in the
MS delta region.
17/ A crop group tolerance is not appropriate at this time for the following reasons: Residue data are required for one
additional member of this group (peppers); currently, a tolerance exists for residues in or on tomatoes only.
18/ A food additive tolerance of 0.2 part per million must be proposed for the combined residues of metribuzin and its
triazinone metabolites in concentrated tomato products.
19/ A crop group tolerance is not appropriate at this time for the following reasons:
a. Residue data are required for two additional members of this group (rice and sorghum); metribuzin formulations
are currently registered for use only on barley, corn and wheat.
b. The established tolerances for metribuzin residues in or on fresh corn (including kernels plus cobs with
husks removed) and corn grain (including popcorn) for 0.05 ppm and the established tolerances (0.75 ppm) for
residues in or on barley and wheat grain differ by more than a factor of five.
c. Additional residue data are required to support the currently established tolerance for residues in or on
field corn grain.
65
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHEMICAL: METRIBUZIN
§158.125 Residue Chemistry - Continued
20/ Additional data are not required for this topic because similar data requirements exist for wheat milled products
which, upon their receipt, will be translated to barley milled products.
21 / The following data are required to support the tolerance on corn grain:
a. Residue data for field corn grain harvested at normal maturity (~70-89% dry matter) after a single preemergence
application with the 50% WP or the 4 Ib/gal PLC formulation at 0.5 Ib ai/A. Tests should be conducted in IA, MN,
and NE as these states represent the major US corn production areas in which use of metribuzin on field corn is
permitted.
b. Field corn grain bearing detectable weathered residues of metribuzin must be processed into oil (crude and refined)
and milled products; residues of metribuzin per se, DA, DK and DADK in these products must be sought. Exaggerated
rates may be necessary to obtain detectable residues in or on grain. If residues concentrate in any of these
products, appropriate food additive tolerances must be proposed.
22/ A feed additive tolerance of 0.1 ppm must be proposed for metribuzin residues for fresh corn cannery waste.
23/ Wheat grain bearing detectable weathered residues of metribuzin must be processed into germ and milled products and
combined residues of metribuzin per se, DA, DK and DADK in these items must be determined. Exaggerated rates may be
necessary to obtain residues in or on grain.
24/ A crop group tolerance is not appropriate at the present time for the following reasons:
a. Additional residue data are required to support the currently established tolerance for residues in or on corn
fodder.
b. The established tolerances for metribuzin residues in or on corn forage (0.1 ppm) and wheat forage (2 ppm)
differ by a factor >5X.
c. Data and tolerance proposals must be submitted for residues in or on barley forage and hay, corn silage, and wheat
hay; in the case of barley, grazing and feeding restrictions may be proposed in lieu of additional data.
25/ The available data are adequate to support tolerances on barley straw. Tolerances of 2 ppm for residues of metribuzin
must be proposed for barley forage and straw. Alternatively, the present restriction against feeding or grazing barley
prior to maturity may be amended to prohibit grazing or feeding treated barley, in any stage of maturity, to livestock.
If tolerances are sought no additional data are required because data on wheat forage and data requested for wheat hay
will be translated to barley forage and hay.
26/ Data are adequate to support the corn forage tolerance but not the corn fodder data. Data should be submitted and a
tolerance proposed for corn silage. The following data are required:
a. Data concerning residues in or on corn fodder harvested at normal maturity following a single preemergence broadcasl
application with either the 50 WP or 4 Ibs/gal FLC formulation at 0.25 Ib ai/A. Tests must be conducted in
representative states in which treatment of field corn is permitted.
b. Residue data for corn silage harvested from fields treated with a single preemergence broadcast application with
the 50% WP or 4 Ib/gal FLC at 0.25 Ibs ai/A. Tests must be conducted in representative states in which treatment
of field corn is permitted.
66
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHEMICAL: METRIBUZIN
§158.125 Residue Chemistry - Continued
27/ The following additional data are required: Data reflecting residues in or on wheat hay harvested at normal
maturity after a postemergence broadcast application, after wheat has fully tillered, with the 50% or 75%
WP, or the 4 Ib/gal FIG formulation at 0.5 or 0.75 Ibs ai/A. Both aerial and ground application equipment
must be represented. High rate (0.75 Ib ai/A) tests must be conducted in OK and low rate (0.5 ai/A) tests
must be conducted in ID and UT, east of the Cascades.
28/ A crop group tolerance is not appropriate at this time for the following reasons:
a. Data are required for representative members of the crop group (Bermuda grass, bluegrass, and brumegrass
or fescue)
b. A use has not been registered for applications to grass. The currently established tolerances for combined
residues of metribuzin in or on grass forage and hay are for residues incurred in mixed stands with
alfalfa for which use are registered.
29/ A crop group tolerance is not appropriate at this time for the following reasons:
a. Residue data are required for one additional member of this group (clover). Presently, metribuzin is registered
for use on two members of this crop group (alfalfa and sainfoin).
b. Data and a.tolerance proposal for residues in or on alfalfa seed are required.
30/ The available data are adequate to support tolerances on alfalfa forage and hay. A tolerance is necessary
for residues in or on alfalfa seed. The following data are required: Residue data from mature alfalfa seed
harvested 28 days after the record of two applications at 1 Ib ai/A using the 4 Ib/gal FIC or a W.P. These
applications should represent fall and spring dormant applications no more than 5-6 months apart; a smaller
treatment to major U.S. alfalfa growing regions. An appropriate tolerance must be proposed.
31 / A tolerance of 0.1 ppm on asparagus must be proposed for the combined residues of metribuzin and its
triazinone metabolites.
32/ The following additional data are required. Residues must be determined in or on the sugarcane forage
grown at HI at intervals following a spot treatment of the 50%, 70%, or 75% WP or the 4 Ib/gal FIC at 5 Ib ai/A
vhich was preceded by a postemergence treatment at 3 Ib/A; a pregrazing interval and tolerance for
residues must be proposed; alternatively, a grazing restriction may be proposed.
33/ The following additional data are required: Residues must be determined in molasses, refined sugar, and
bagasse processed from sugarcane bearing measurable weathered residues of metribuzin, DA, DK and DADK.
If residues are found to concentrate in refined sugar, an appropriate food additive tolerance must be
processed. The established food/feed tolerance must be proposed. The established food/feed additive
tolerance for residues in molasses and bagasse will be assessed on receipt of the above-requested data.
34/ The nature of the residue in ruminants (including milk, meat, eggs) is not adequately understood.
The adequacy of these tolerances and of the data submitted in support of the established tolerances cannot
be assessed at this time. On a receipt of data requested in "Nature of Residue of Animals," the adequacy of
the available data and the established tolerance will be assessed.
67
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Does EPA Have Must Additional Data
Data To Satisfy Be Submitted Under
Use£/ This Require- Bibliographic FIFRA $ 3(c)(2)(B)?
Data Requirements Composition1/ Pattern ment? (Yes, No Citation Timeframes For Data
or Partially) Submission?/
$158.130 Environmental Fate
DEGRADATION STUDIES-LAB:
161-1 - Hydrolysis TGAI or PAIRA A,B No
Photodegradation
161-2 - In Water TGAI or PAIRA A,B No
161-3 - On soil TGAI or PAIRA A Partially 00045259
161-4 - In Air TGAI or PAIRA A No
METABOLISM STUDIES-LAB:
162-1 - Aerobic Soil TGAI or PAIRA A,B NO
162-2 - Anaerobic Soil TGAI or PAIRA A No
162-3 - Anaerobic Aquatic TGAI or PAIRA No
162-4 - Aerobic Aquatic TGAI or PAIRA NO
MOBILITY STUDIES:
Yes^A/ 9 Months
Yes 9 Months
Yes3A/f/ 9 Months
No3A/
Yes^A/ 27 Months
Yes3jV 27 Months
NO*/
No?/
1 63-1 - Leaching and
Adsorption/Desorption
TGAI or PAIRA
A,B
Partially
00025729 00054368
00029887 00045268
Yes3A,8/ 12 Month
163-2 - Volatility (Lab)
163-3 - Volatility (Field)
TEP
TEP
A
A
No
No
68
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Data Requirements
Use^/
Composition^/ Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Tank Mixes
164-5 - Soil, Long-term
ACCUMULATION STUDIES;
165-1 - Rotational Crops
(Confined)
165-2 - Rotational Crops
(Field)
165-3 - Irrigated Crops
165-4 - In Fish
165-5 - In Aquatic Nontarget
Organisms
MONITORING STUDIES:
Ground water Monitoring
Studies
TEP
PAIRA
TEP '
TEP
TGAI or PAIRA
TEP
A,B
No
NO
No
No
No
No
69"
Must Additional Data
Be Submitted Under
FIFRA $ 3(c)(2)(B)?
Timeframes For Data
Submission?/
$158.130 Environmental Fate -
DISSIPATION STUDIES-FIELD:
164-1 - Soil
164-2 - Aquatic (Sediment)
164-3 - Forestry
164-4 - Combination and
Continued
TEP
TEP
TEP
A,B No Yes^/ 27 Months
No No1 1 /
No NoJ£/
No No1 V
39 Months
50 Months
Yes 12 Months
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
§158.130 Environmental Pate - Continued
I/ Composition: TGAI = Technical grade of the active Ingredient; PAIRA = Pure active Ingredient, radiolabeled;
TEP = Typical end-use product.
2/ The use patterns are coded as follows: A = Terrestrial, Pood Crop; B = Terrestrial, Non-food; C = Aquatic,
Pood Crop; D = Aquatic, Non-food; E = Greenhouse, Pood Crop; P = Greenhouse, Non-food; G = Forestry; H = Domestic
Outdoor; I = Indoor.
3/ Data must be submitted within the indicated time frame, based on the date of the Guidance Document.
0 9 Month Due Date is March 31, 1986 .
0 12 Month Due Date is June 30, 1986
0 27 Month Due Date is September 30, 1987
0 39 Month Due Date is September 30, 1988
0 50 Month Due Date is February 28, 1989
3A/ Data In response to the Data Call-in for groundwater including hydrolysis, photodagration in water and on soil, aerobic
and anaerobic soil metabolism, mobility, and field dissipation have been received and screened. Any valid studies
which meet guidelines will reduce the data gaps.
V This study will be acceptable if additional data are provided on the factors affecting the incident sunlight as
well as its intensity and duration.
5/ This compound does not require data on photodegradation in air.
t>/ Data are not required because metribuzln has no forestry, or aquatic use.
7/ Data are not required because metribuzln has no aquatic use.
F/ Additional data are needed on the leaching or adsorption/desorptlon of the soil degradation products of metribuzln.
9/ The compound does not require volatility (lab) data.
lp_/ The compound does not require volatility (field) data.
ll/ Data are not required because metribuzln has no aquatic uses.
12/ Data are not required because metribuzin has no forestry uses.
13/ Data requirements for combination products and tank mixes are not addressed in this Standard.
lit/ Data are not required since results of the valid terrestrial field dissipation data indicated that greater
than 50% of the residues dissipate prior to recommended subsequent application.
15/ For crops rotated on treated areas, any one of the following would apply:
a. A tolerance must be obtained for the rotated crop.
b. The product label must include a restriction against the rotation of crops used for feed or food which are
not registered for use with metribuzin.
c. Data must be provided to determine time intervals at which rotated crops planted In treated areas will be free
of pesticide residues.
15A/ Conditional on results from confined studies.
~Io7 No data are required because metribuzln does not have an aquatic food crop or aquatic noncrop use is not used in and
around holding ponds used for irrigation purposes, and has no use involving effluents or discharges to water used
for crop irrigation.
17/ No data are required because metribuzin has no forestry aquatic noncrop, or aquatic Impact use.
IF/ Ground water monitoring studies will be required. Notification of types of studies required and sites to be tested
(Agency is in process of determining types of studies and test sites), by means of an amendment to the standard
3 months of issuance of the standard. A time limit for submis^^n of data will be set at that time.
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Does EPA Have
Data To Satisfy
Ose^/ This Require-
Data Requirements Composition1/ Pattern ment? (Yes, No
or Partially)
$158.130 Toxicology
ACUTE TESTING:
81-1 - Acute Oral Toxicity - Rat TGAI A,B Yes
81-2 - Acute Dermal Toxicity TGAI A,B Yes
- Rabbit
81-3 - Acute Inhalation Toxicity TGAI A,B No
- Rat
81-7 - Delayed TGAI No
Neurotoxicity - Hen
SUBCHRONIC TESTING:
82-1 - 90-Day Feeding: TGAI A,B No
- Rodent, and
- Non- rodent (Dog) A,B No
82-2 - 21 -Day Dermal - Rabbit TGAI A,B No
82-3 - 90-Day Dermal - Rabbit TGAI A,B No
82-4 - 90-Day Inhalation: TGAI A,B No
- Rat
82-5 - 90-Day Neuro toxic ity: TGAI A,B No
- Hen
- Mammal A, B No
Must Additional Data
Be Submitted Under
Bibliographic FIFRA $ 3(c)(2)(B)?
Citation Timeframes For Data
Submission?-/
001 061 58 No
00106149 No
Yes4/ 9 Months
No5/
No6/
NO7/
NO8/
No8/
No8/
No8/
No8/
71
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Data Requirements Composition1/
§158.130 Toxicology - Continued
CHRONIC TESTING:
83-1 - Chronic Toxic ity - TGAI
2 species:
- Rodent, and
- Non- rodent (Dog)
83-2 - Oncogenicity - TGAI
2 species:
- Rat (preferred), and
- Mouse (preferred)
83-3 - Teratogenicity - TGAI
2 species :
- Rat
- Rabbit
83-4 - Reproduction - Rat TGAI
2-generation
MOTAGENICITY TESTING:
84-1 - Gene Mutation (Ames Test) TGAI
84-2 - Structural Chromosomal TGAI
Aberration
Does EPA Have Must Additional Data
Data To Satisfy Be Submitted Under
Use2/ This Require- Bibliographic FIFRA § 3(c)(2)(B)?
Pattern ment? (Yes, No Citation Timeframes For Data
or Partially) Submission?/
A.B No Yes9/ 49 Months
A,B Yes 00061260 No
A.B No Yes9/ 50 Months
A,B Yes 00061256 No
00079527
00087795
A,B No Yes10/ 15 Months
A,B Yes 00087796 No
A,B No Yes11/ 39 Months
A,B Partially 00086770 YesJ£/ 9 Months
A,B Partially 00086766 00086767 Yes12/ 12 Months
00086765 00086768
72
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Data Requirements
Composition!/
Use£/
Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Dat
Be Submitted Under
FIPRA § 3(e)(2)(B)?
Timeframes Por Data
SubmissionB/
§158.130 Toxicology - Continued
84-3 - Other Genotoxic Effects
SPECIAL TESTING;
85-1 - General Metabolism
85-2 - Dennal Penetration
86-1 - Domestic Animal
Safety
TOAI A,B
PAI or PAIRA A,B
Choice
Choice
No
No
No
No
12 Months
Yes^3/ 24 Months
Yes 12 months
73
-------
£ TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
$158.130 Toxicology - Continued
V Composition: PAI = Pure active ingredient; PAIRA = Pure active ingredient, radiolabeled; Choice = Choice of
several test substances determined on a case-by-case basis; TGAI - Technical grade of active ingredient.
2/ The use patterns are coded as follows: A = Terrestrial, Food Crop; B = Terrestrial, Non-food; C = Aquatic,
Food Crop; D = Aquatic, Non-food; E = Greenhouse, Food Crop; F = Greenhouse, Non-food; G = Forestry, H = Domestic
Outdoor; I = Indoor.
3/ Data must be submitted within the indicated time frame, based on the date of the Guidance Document.
March 31 , 1986 _ .
9 Month Due Date is
12 Month Due Date is
15 Month Due Date is
24 Month Due Date is
39 Month Due Date is
50 Month Due Date is
June 30^ 1986
September 30 , 1 986
June 30 ,_ 1987
September 30 ,_ 1988
August 31 \_,_ 1 989
_4/ Additional data are required because the study reviewed was classified as supplementary data.
5_/ Since metribuzin is not a cholinesterase inhibitor and does not otherwise indicate neurotoxicity, these data
are not required.
6/ An acceptable chronic rat feeding study will fulfill the requirement for a subchronic rat study.
7/ The chronic dog study satisfies the requirement for a subchronic dog study.
8/ The guidelines and uses generally indicate that these data are not required.
9/ The submitted study is classified supplementary data. If additional data can be submitted, this study may
be upgraded. If not, a repeat study will be necessary.
10/ A teratogenicity study in rats is required because the study previously submitted was reviewed by the Agency
and found to be supplementary.
11 / Additional data are required because the high dose of the study previously submitted did not induce any toxicity,
therefore, the study is classified as supplementary data.
JJ2/ The following mutagenicity data are required.
a. Microbial point mutation tests.
b. Mammalian point mutation tests in vitro.
c. In vivo cytogenetics tests in mammals with either heritable translocation or dominant lethal studies.
d. Tests for primary DNA damage such as sister chromatid exchange or unscheduled DNA synthesis assays.
13/ Additional data are needed because previously submitted data were reviewed as supplementary data.
74
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Does EPA Have Must Additional Data
Data To Satisfy Be Submitted Under
Use2/ This Require- Bibliographic FIFRA § 3(c)(2)(B)?
Data Requirements Composition^/ Pattern ment? (Yes, No Citation Timeframes For Data
or Partially) Submission
$158.140 Reentry Protection
132-1 - Foliar Dissipation TEP No
1 32-1 - Soil Dissipation TEP No
1 33-3 - Dermal Exposure TEP No
133-4 - Inhalation Exposure TEP No
$158.142 Spray Drift
201-1 - Droplet Size Spectrum TEP No
201-1 - Drift Field Evaluation TEP No
No3/
No3/
No3/
No3/
No3/
No3/
_!_/ Composition: TEP = Typical end-use product.
_2/ The use patterns are coded as follows: A = Terrestrial, Food Crop; B = Terrestrial, Non-food; C = Aquatic, Food Crop;
"~ D = Aquatic, Non-food; E = Greenhouse, Food Crop; F = Greenhouse, Non-Food; G = Forestry; H = Domestic Outdoor;
I = Indoor.
3/ Because of its low toxicity category (III), metribuzin does not required reentry data.
75
-------
GENERIC
TABLE A
DATA REQUIREMENTS FOR METRIBUZIN
Data Requirements Composition1/
§158.145 Wildlife and
Aquatic Organisms
AVIAN AND MAMMALIAN TESTING:
71-1 - Acute Avian Oral Toxicity TGAI
TEP
71-2 - Avian Subacute Dietary TGAI
Toxicity
- Upland Game Bird, and
- Waterfowl
71-3 - Wild Mammal Toxicity TGAI
71 -4 - Avian Reproduction TGAI
- Upland Game Bird, and
- Waterfowl
71-5 - Simulated Field Testing TEP
- Mammals and
- Birds
- Actual Field Testing TEP
- Mammals, and
- Birds
UseV
Pattern
A,B
A,B
A,B
A,B
A,B
A,B
A,B
A,B
A,B
A,B
A,B
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Yes
Partially
Yes
Partially
No
No
No
Partially
Partially
Partially
Partially
Must Additional Data
Be Submitted Under
Bibliographic FIFRA 5 3(c)(2)(B)?
Citation Timeframes For Data
Submission!/
GS 01 81 -009 No
00051 482 No J4/
00065507 No
00065507 Yesjy
No6/
9 Months
Reserved7/
Reserved7/
00035931 No
00035931 No
00035931 NO
00035931 No
76
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Use?/
Data Requirements Composition1/ Pattern
$158.145 wildlife and
Aquatic Organisms - Continued
AQUATIC ORGANISM TESTING:
72-1 - Freshwater Fish Toxicity TGAI
- Coldwater Fish Species, A,B
and
- Warmwater Fish Species A, B
72-2 - Acute Toxicity to TGAI
Freshwater Invertebrates A, B
72-3 - Acute Toxicity to TGAI
Estuarine and Marine
Organisms
- Fish A
- Mollusk A
- Shrimp A
72-4 - Fish Early-Life Stage, TGAI A,B
and
- Aquatic Invertebrate A,B
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Yes
Yes
Yes
No
Partially
Yes
No
No
Must Additional Data
Be Submitted Under
Bibliographic FIFRA f 3(c)(2)(B)?
Citation Timeframes For Data
Submission3./
GS0181-O08 No
GS0181-O08 No
001 34495 NO
Yes8/ 12 Months
00106197 YesjV 12 Months
OO1O6197 No
Reserved9/
Reserved9/
Life-Cycle
77
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR HETRIBUZIN
Does EPA Have Must Additional Data
Data To Satisfy Be Submitted Under
Use£/ This Require- Bibliographic FIFRA $ 3(c)(2)(B)?
Data Requirements Composition1/ Pattern ment? (Yes, No Citation Timeframes For Data
or Partially) Submission2/
§158.145
Aquatic
72-5 -
72-6 -
72-7 -
Wildlife and
Organisms - Continued
Fish - Life-Cycle TGAI A,B No
Aquatic Organism TGAI, PAI or
Accumulation Degradation
Product
- Crustacean A, B No
- Fish A,B No
- Insect Nymph A,B No
- Mollusk A,B No
Simulated Field Testing TEP A,B No
No
i
Reserved^/
Reserved^/
Reserved^/
Reserved^/
Reserved^/
- Aquatic Organisms
- Actual Field Testing
- Aquatic Organisms
A,B
No
Reserved^/
78
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Si 58.145 Wildlife and Aquatic Organisms - Continued
\J Composition: TGAI = Technical grade of the active ingredient; PAI = Pure active ingredient, TEP = Typical
end-use product.
2/ The use patterns are coded as follows: A = Terrestrial, Food Crop; B = Terrestrial, Non-food Crop; C = Aquatic,
Food Crop; D = Aquatic, Non-food; E = Greenhouse, Food Crop; F = Greenhouse, Non-food; G = Forestry, H = Domestic
Outdoor; I = Indoor.
3/ Data must be submitted within the indicated time frame, based on the date of the Guidance Document.
0 9 Month Due Date is March 311, 1986 .
0 12 Month Due Date is June 30, 1986
4/ There are currently no requirements for this type of study.
5/ Additional data are required for upland avian species.
6/ The low avian and mammalian toxicity for metribuzin indicate that these data are not required.
TJ Requirements are reserved pending dietary data on an upland species and appropriate environmental fate
information.
8/ Data are needed on an estuarine/marine fish species and an oyster species to support sugarcane and
soybean registration.
9/ Appropriate environmental fate information is needed to determine if potentially hazardous concentrations will reach
the aquatic environment when products are used as directed.
79
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Data Requirements
Composition1 /
Use
Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Timeframes For Data
Submission
§158.150 Plant Protection
121-1 - TARGET AREA EP
PHYTOTOXICITY
NONTARGET AREA PHYTOTOXICITY
TIER I
122-1 - Seed Germination/ TGAI
Seedling Emergence
No
No
No2/
122-1
122-2
123-1
123-1
123-2
124-1
124-2
- Vegetative Vigor
- Aquatic Plant Growth
TIER II
- Seed Germination/
Seedling Emergence
- Vegetative Vigor
- Aquatic Plant Growth
TIER III
- Terrestrial Field
- Aquatic Field
TGAI
TGAI
TGAI
TGAI
TGAI
TEP
TEP
No
No
No
No
No
No
No
No2/
No2/
_ No2/
NoV
No2/
No2/
No2/
_1/ Composition: TGAI = Technical grade of the active ingredient; TEP = Typical end-use product. EP = End-use product.
2/ These requirements are generally waived unless it is believed there is a phototoxicity problem.
80
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBUZIN
Data Requirements
Composition1/
Use2/
Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA § 3(C)(2)(B)?
Timeframes For Data
Submission
§158.155 Nontarget Insect
NONTARGET INSECT TESTING -
POLLINATORS;
141-1 - Honeybee acute
contact toxicity TGAI
1 41 -2 - Honeybee - toxicity TEP
of residues on
foliage
141 -4 - Honeybee subacute
feeding study
A
A
(Reserved)^/
141-5 - Field testing for TEP
pollinators
Yes
No
00028772
No
No
No4/
81
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METRIBOZIN
Does EPA Have Must Additional Data
Data To Satisfy Be Submitted Under
Use£/ This Require- Bibliographic FIFRA § 3(c)(2)(B)7
Data Requirements Composition^/ Pattern ment? (Yes, No Citation Timeframes For Data
or Partially) Submission
§158.155 Nontarget Insect - Continued
NONTARGET INSECT TESTING -
AQUATIC INSECTS;
142-1 - Acute toxicity to (Reserved)^/
aquatic insects
142-1 - Aquatic insect (Reserved)V
life-cycle study
142-3 - Simulated or actual (Reserved )_•>/
field testing for
aquatic insects
143-1 - NONTARGET INSECT (Reserved )jy
TESTING - PREDATORS
AND PARASITES
thru
143-3
I/ Composition: TGAI = Technical grade of the active ingredient; TEP = Typical end-use product.
~2/ The use patterns are coded as follows: A = Terrestrial, Food Crop; B = Terrestrial, Non-food Crop; C = Aquatic,
~~ Food Crop; D = Aquatic, Non-food; E = Greenhouse, Food Crop; F = Greenhouse, Non-food, G = Forestry; H = Domestic
Outdoor; I = Indoor.
3/ Reserved pending development of test method.
T/ Requirement applied on a case-by-case basis. Data reviewed to date do not indicate the need for a study.
I/ Reserved pending Agency decision as to whether data requirement should be established.
82
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING METRIBUZIN (94% TECHNICAL)
Guideline Citation and
Name of Test
§158.120 Product Chemistry
Product Identity:
61 -1 - Product Identity and Disclosure
of Ingredients
61 -2 - Description of Beginning Materials
and Manufacturing Process
61 -3 - Discussion of Formation of
Impurities
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
62-2 - Certification of Limits
62-3 - Analytical Methods to Verify
Certified Limit
Physical and Chemical Characteristics
63-2 - Color
63-3 - physical State
63-4 - Odor
Test Guidelines Are Data
Substance Status Required
Yes No
MP R M [30
MP R [JC] Q
m M
MP R
MP CR [X] M
MP R [5F] Q
MP R [X] M
MP R M [X]
MP R M [JC]
MP R [X] M
Data Must Be
Footnote Submitted Withir
Number Timeframes Liste
Belowl/
2,3 6 Months
4 6 Months
5 12 Months
6,7 12 Months
8 12 Months
6 Months
::::::::::::::::::::::::
83
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING METRIBDZIN (94% TECHNICAL)
Guideline Citation and
Name of Test
$158.120 Product Chemistry
Physical and Chemical Characteristics
(Continued)
63-7 - Density, Bulk Density, or
Specific Gravity
63-12 - pH
63-14 - Oxidizing or Reducing
Action
63-15 - Flammability
63-16 - Explodability
63-17 - Storage Stability
63-18 - Viscosity
63-19 - Miscibility
63-20 - Corrosion Characteristics
Other Requirements:
64-1 - Submittal of samples
Test Guidelines
Substance Status
MP R
CR
MP
MP CR
MP CR
MP R
MP R
MP CR
MP CR
MP R
MP CR
Are Data
Required
Yes No
[xi n
[X] M
[xi n
[xi n
[xi n
ixi n
[xj n
ix] n
txi n
n [xi
Data Must Be
Footnote Submitted Within
Number Timeframes Idsto
Belowl/
6 Months
6 Months
6 Months
6 Months
6 Months
15 Months
6 Months
6 Months
15 Months
MP = Manufacturing-use Product; R = Required; CR = Conditionally Required.
_1/ Data must be submitted within the indicated time frame, based on the date of the Guidance Document.
0 6 Month Due Date is December 31; 1985 .
0 12 Month Due Date is June 30, 1986 .
0 15 Month Due Date is September 30, 1986 .
_2/ Details of the manufacturing process including the relative amounts of beginning materials, a description of the
equipment used to produce the product, reaction conditions, the dura£L£n of each step in the process, purification
measures for the 94% technical must:
itted.
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING METRIBUZIN (94% TECHNICAL)
§158.120 Product Chemistry - Continued
_3/ The name and address of the manufacturer, producer, or supplier of each beginning material used to manufacture the
94% technical and a copy of all available technical specifications, data sheets, and other documents by which the
manufacturer, producer, or supplier of beginning materials describes its composition and properties.
_4_/ A discussion of each impurity believed to be present at >0.1% based on knowledge of the beginning maerials, all possibl
chemical reactions and any contamination.
S/ Five or more representative samples should be analyzed for the amount of active ingredient and each impurity present
for which a certified limit is required.
_6/ A current Confidential Statement of Formula must be submitted.
2/ The following additional data are required:
a. Upper and lower limits must be provided (and certified) for metribuzin in 94% technical.
b. Upper limits must be provided (and certified) for each impurity present at >0.1% in the 94% technical.
c. All nitrosamines must be identified and quantified in six samples in 94% technical product; two samples
of each must be analyzed shortly after production, 3 months after production, and 6 months after production.
A method sensitive to 1 ppm of N-Nitroso contaminants must be used. An upper limit must be provided (and
certified) for all nitrosamines found to be present.
8/ Quantitative methods to determine all impurities for which a certified limit is required on 94% technical. Each method
must be accompanied by the validation studies of precision and accuracy of the method.
85
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACUTRING-USE PRODUCTS CONTAINING METRIBUZIN (94% TECHNICAL)
Data Requirements
Composition1/
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA $ 3(c)(2)(B)?
Timeframes For Data
Submission^-/
58.135 Toxicology
ACUTE TESTING:
81-1 - Acute Oral Toxicity - Rat
81-2 - Acute Dermal Toxicity
- Rabbit
81-3 - Acute inhalation Toxicity
- Rat
MP
MP
MP
Yes
Yes
No
00106158
00106149
No
No
Yes3/ 9 Month
81-4 - Primary Eye
Irritation - Rabbit
MP
Yes
GS0181-010
No
81-5 - Primary Dermal
Irritation - Rabbit
81-6 - Dermal Sensitization -
Guinea Pig
MP
MP
Yes
Yes
GS0181-010
00034014
No
No
1/ Composition: MP = Manufacturing-use product.
2/ Data must be submitted within the indicated time frame, based on the date of the Guidance Document.
~~ ° 9 Month Due Date is March 311 , 1986 .
3/ Additional data are needed because the study was classified as supplementary data.
66
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING METRIBUZIN (50% FI)
Guideline Citation and
Name of Test
§158.120 Product Chemistry
Product Identity:
61 -1 - Product Identity and Disclosure
of Ingredients
61 -2 - Description of Beginning Materials
and Manufacturing Process
61 -3 - Discussion of Formation of
Impurities
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
62-2 - Certification of Limits
62-3 - Analytical Methods to Verify
Certified Limit
•a*
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical State
63-4 - Odor
Test
Substance
MP
MP
MP
MP
MP
MP
MP
MP
MP
Guidelines
Status
R
R
R
CR
R
R
R
R
R
Are Data Footnote
Required Number
Yes No
[X] M
[X] M 2,3
[JC] M 4
[X] M 5
[X] M 6,7
[5C] M 8
[X] M
[x~] M
[x] M
Data Must Be
Submitted Withi
Timefr antes List
Below!/
6 Months
6 Months
6 Months
12 Months
12 Months
12 Months
6 Months
6 Months
6 Months
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING METRIBUZIN (50% FI)
Guideline Citation and
Name of Test
§158.120 Product Chemistry- (continued)
Physical and Chemical Characteristics
(Continued)
--•#
63-7 - Density, Bulk Density, or
Specific Gravity
63-12 - pH
63-14 - Oxidizing or Reducing
Action
63-15 - Flammability
63-16 - Explodability
63-17 - Storage Stability
63-18 - Viscosity
63-19 - Miscibility
63-20 - Corrosion Characteristics
Other Requirements
64-1 - Submittal of samples
MP = Manufacturing-use Product; R = Requir
1/ Data must be submitted within the indie
0 6 Month Due Date is December 31 ,
0 12 Month Due Date is June 30, 1986
0 15 Month Due Date is September 30,
Test Guidelines Are Data Footnote
Substance Status Required Number
Yes No
MP R [x"] [~]
MP CR [X] M
MP CR [X] M
MP CR [jF] [~ ]
MP R [X"] M
MP R [X~] M
MP CR [X"] M
MP CR [X] [~]
MP R [X] M
MP CR M [X"]
ed; CR = Conditionally Required:
ated time frame, based on the date of the Guidance Document.
1985 .
88
1986
Data Must Be
Submitted Within
Timeframes Listed
BelowL/
6 Months
6 Months
6 Months
6 Months
6 Months
1 5 Months
6 Months
6 Months
15 Months
2/ Details of the manufacturing process including the relative amounts of beginning materials, a description of the
~~ equipment used to produce the product, reaction conditions, the duration of each process, purification procedures
and quality control measures for 50% F.I must be submitted.
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING METRIBUZIN (50% FI)
§158.120 Product Chemistry - Continued
_3/ The name and address of the manufacturer, producer, or supplier of each beginning material used to manufacture
the 50% FI and a copy of all available technical specifications, data sheets, and other documents by which
the manufacturer, producer, or supplier of the beginning material describes its composition and properties.
V A discussion of each impurity believed to be present at >0.1% based on knowledge of the beginning materials, all
possible chemical reactions and any contamination.
_5/ Five or more representative samples should be analyzed for the amount of active ingredient and each impurity present
for which a certified limit is required.
6/ A current Confidential Statement of Formula must be submitted.
7_/ The following data are required:
a. Upper and lower limits must be provided (and certified) for metribuzin and each intentionally added inert in the
50% FI.
b. Upper limits must be provided (and certified) for each impurity present at >0.1% (w/w) in the 50% FI.
c. The purpose of each intentionally-added inert in 50% F.I. must be provided.
d. All nitrosamines must be identified and quantified in six samples in 50% F.I. products; two samples
of each must be analyzed shortly after production, 3 months after production, and 6 months after production.
A method sensitive to 1 ppm of N-Nitroso contaminants must be used. An upper limit must be provided (and
certified) for all nitrosamines found to be present.
8/ Quantitative methods to determine all impurities for which a certified limit is required on 50% F.I. products.
Each method must be accompanied by validation studies of the precision and accuracy of the method.
89
-------
35
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACUTRING-USE PRODUCTS CONTAINING METRIBUZIN (50% F.I.)
Data Requirements
Composition^/
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA 5 3(c)(2)(B)?
Timeframes For Data
Submission?/
§158.135 Toxicology
ACUTE TESTING:
81-1 - Acute Oral Toxicity - Rat
81 -2 - Acute Dermal Toxicity
- Rabbit
81-3 - Acute Inhalation Toxicity
- Rat
MP
MP
MP
Yes
Yes
No
00106158
00106149
No
No
Yes3/ 9 Months
81-4 - Primary Eye
Irritation - Rabbit
MP
Yes
GS0181-010
No
81-5 - Primary Dermal
Irritation - Rabbit
MP
Yes
GS0181-010
No
81-6 - Dermal Sensitization -
Guinea Pig
MP
Yes
00034014
No
\J Composition: MP = Manufacturing-use product.
2/ Data must be submitted within the indicated time frame, based on the date of the Guidance Document.
0 9 Month Due Date is March 31, 1986 .
_3/ Additional data are needed because the study was classified as supplementary data.
90
-------
IV. SUBMISSION OF REVISED LABELING
Note; This section applies to end use products only to the
extent described in Section I (Regulatory Position and
Rationale). Otherwise, the following information pertains
exclusively to manufacturing use products.
PIPRA requires each product to be labeled with accurate,
complete and sufficient instructions and precautions, reflecting
the results of data concerning the product and its ingredients.
Labeling requirements are set out in 40 CPR 162.10 (see
Appendix IV-1) and are summarized for products containing
this active ingredient as part of this Guidance Document
(See Appendix IV-2). Applications submitted in response to
this notice must include draft labeling for Agency review.
If you fail to submit revised labeling information
complying with this section (supplemented by requirements
described in Section I, Regulatory Position and Rationale),
EPA may issue a notice of intent to cancel the registration
under PIPRA sec. 6(b)(l).
A. Label Contents
40 CPR 162.10 requires that certain specific labeling
statements appear at certain locations on the label. This
is referred to as format labeling. Specific label items
listed below are keyed to Appendix IV-2.
Item 1. PRODUCT NAME - The name, brand or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading.
Item 2. COMPANY NAME AND ADDRESS - The name and address
of the registrant or distributor is required on the label.
The name and address should preferably be located at the
bottom of the front panel or at the end of the label text.
Item 3. NET CONTENTS - A net contents statement is
required on all labels or on the container of the pesticide.
The preferred location is the bottom of the front panel
immediately above the company name and address, or at the end
of the label text. The net contents must be expressed in the
largest suitable unit, e.g., "1 pound 10 ounces" rather than
"26 ounces." In addition to English units, net contents may
be expressed in metric units. See Appendix IV-1. [40 CPR
I62.10(d)]
91
-------
Item 4. EPA REGISTRATION NUMBER - The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase "EPA Registration No.," or "EPA
Reg. No." The registration number must be set in type of a
size and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
registration number and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency. See Appendix IV-1.
[40 CPR I62.10(e)]
Item 5. EPA ESTABLISHMENT NUMBER - The EPA establishment
number, preceded by the phrase "EPA Eat." is the final estab-
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment number on the immediate
container cannot be clearly read through such wrapper or container.
See Appendix IV-1. [40 CPR l62.10(f)]
Item 6A. INGREDIENTS STATEMENT - An ingredients statement
is required on the front panel. The ingredients statement must
contain the name and percentage by weight of each active Ingredient
and the total percentage by weight of all inert ingredients.
The preferred location is immediately below the product name.
The ingredients statement must run parallel with, and be clearly
distinguished from, other text on the panel. It must not be
placed in the body of other text. See Appendix IV-1. [40 CPR
I62.10(g)]
Item 6B. POUNDS PER GALLON STATEMENT - For liquid agricul-
tural formulations, the pounds per gallon of active ingredient
must be indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS - Front panel
precautionary statements must be grouped together, preferably
within a block outline. The table below shows the minimum type
size requirements for various size labels.
Size of Label Signal Word "Keep Out of Reach
on Front Panel Minimum Type Size of Children"
in Square Inches All Capitals Minimum Type Size
5 and under 6 point 6 point
above 5 to 10 10 point 6 point
above 10 to 15 12 point 8 point
above 15 to 30 14 point 10 point
over 30 18 point 12 point
-------
Item 7A. CHILD HAZARD WARNING STATEMENT - The statement
"Keep Out of Reach of Children" must be located on the front
panel above the signal word except where contact with children
during distribution or use is unlikely. See Appendix IV-1.
[40 CPR I62.10(h)(l)(ii)]
Item 7B. SIGNAL WORD - The signal word (DANGER, WARNING,
or CAUTION) is required on the front panel Immediately below
the child hazard warning statement. See Appendix IV-1.
[40 CPR 162.10 (h)(l)(i)]
Item 7C. SKULL & CROSSBONES AND WORD "POISON" - On products
assigned a toxicity Category I on the basis of oral, dermal,
or inhalation toxicity, the word "Poison" shall appear on the
label in red on a background of distinctly contrasting color and
the skull and crossbones shall appear in Immediate proximity to
the word POISON. See Appendix IV-1. [40 CPR I62.10(h) (1) (I)]
Item 7D. STATEMENT OP PRACTICAL TREATMENT - A statement
of practical treatment (first aid or other) shall appear on
the label of pesticide products in toxicity Categories I,
II, and III. See Appendix IV-1. [40 CPR l62.10(h) (1) (iii) ]
Item 7E. REFERRAL STATEMENT - The statement "See Side
(or Back) Panel for Additional Precautionary Statements" is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
See Appendix IV-1. [40 CPR I62.10(h)(l) (111)]
Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING - The
precautionary statements listed below must appear together
on the label under the heading "PRECAUTIONARY STATEMENTS."
The preferred location is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline. Each
of the three hazard warning statements must be headed by the
appropriate hazard title. See Appendix IV-1. [40 CPR 162.10
Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS - Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions to be taken to avoid
accident, injury, or damage. See Appendix IV-1. [40 CPR 162.10
93
-------
Item 8B. ENVIRONMENTAL HAZARD - Where a hazard exists to
non-target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage. See Appendix IV-1. [40 CPR
Item 8C. PHYSICAL OR CHEMICAL HAZARD
1. Plammability statement. Precautionary statements relating
to flammability of a product are required to appear on the
label if it meets the criteria in Appendix IV-3. The require-
ment is based on the results of the flashpoint determinations
and flame extension tests required to be submitted for all
products. These statements are to be located in the side/back
panel precautionary statements section, preceded by the
heading "Physical/Chemical Hazards." Note that no signal
word is used in conjunction with the flammability statements.
2 . Criteria for declaration of non-f lammability . The
following criteria will be used to determine if a product
is non-flammable:
a. A "non-flammable gas" is a gas (or mixture of gases)
that will not ignite when a lighted match is placed
against the open cylinder valve-
b. A "non-flammable liquid" is one having a flashpoint
greater than 350°P (177°C).
c. A "non-flammable aerosol" is one which meets the
following criteria:
i. The flame extension is zero inches;
ii. There is no flashback; and
ill. The flashpoint of the non-volatile liquid
component is greater than 350°P (177°C).
3. Declaration of non-f lammability . Products which
meet the criteria for non-f lammability specified
above may bear the notation "non-flammable" or "non-
flammable (gas, liquid, etc.)" on the label. It may
appear as a substatement to the ingredients statement,
or on a back or side panel, but shall not be highlighted
or emphasized (as with an inordinately large type
size) in any way that may detract from precaution.
94
-------
4. Other physical/chemical hazard statements. When
chemistry data demonstrate hazards of a physical or
chemical nature other than flammability, appropriate
statements of hazard will be prescribed. Such statements
may address hazards of explosivity, oxidizing or reducing
capability, or mixing with other substances to produce
toxic fumes.
Item 9A. RESTRICTED USE CLASSIFICATION - PIPRA sec. 3(d)
requires that all pesticide formulations/uses be classified
for either general or restricted use. Products classified
for restricted use may be limited to use by certified applicators
or persons under their direct supervision (or may be subject
to other restrictions that may be imposed by regulation).
In the Registration Standard, the Agency has (1) indicated
certain formulations/uses are to be restricted (Section I
indicates why the product has been classified for restricted
use); or (2) reserved any classification decision until
appropriate data are submitted.
The Regulatory Position and Rationale states whether
products containing this active ingredient are classified
for restricted use. If they are restricted the draft label(s)
submitted to the Agency as part of your application must
reflect this determination (see below).
If you do not believe that your product should be classified
for restricted use, you must submit any information and
rationale with your application for reregistration. During
the Agency's review of your application, your proposed classi-
fication determination will be evaluated in accordance with
the provisions of 40 CPR l62.11(c). You will be notified of
the Agency's classification decision.
A. Classification Labeling Requirements
If Section I of this Guidance Document indicates that
your product has been classified for restricted use, the
following label requirements apply:
1. Front panel statement of restricted use classification.
a. The statement "Restricted Use Pesticide" must
appear at the top of the front panel of the label.
The statement must be set in type of the same
minimum size as required for human hazard signal
word (see table in 40 CPR l62.10(h)(1)(iv).
-------
b. Directly below this statement on the front panel,
a summary statement of the terms of restriction must
appear (including the reasons for restriction if
specified in Section I). If use is restricted to
certified applicators, the following statement is
required: "For retail sale to and use only by
Certified Applicators or persons under their direct
supervision and only for those uses covered by the
Certified Applicator's Certification."
2. Some but not all uses restricted. If the Regulatory
Position and Rationale states that some uses are classified
for restricted use, and some are unclassified, several courses
of action are available:
a. You may label the product for Restricted use-
If you do so, you may include on the label uses that
are unrestricted, but you may not distinguish them
on the label as being unrestricted.
b. You may delete all restricted uses from your
label and submit draft labeling bearing only unrestricted
uses.
c. You may "split" your registration, i.e., register
two separate products with identical formulations, one
bearing only unrestricted uses, and the other bearing
restricted uses. To do so, submit two applications for
reregistration, each containing all forms and necessary
labels. Both applications should be submitted simul-
taneously. Note that the products will be assigned
separate registration numbers.
B. Compliance Schedules
No product with a use classified for restricted use
under this Standard may be released for shipment by the
registrant or producer after one year from the date of
issuance of this Standard, unless such product bears the
restricted use classification. All products still in
channels of trade after two years from the date of issuance
of this Standard must be labeled for restricted use.
Item 9B [There is no Item 9B].
Item 9C. MISUSE STATEMENT - All products must bear the
misuse statement, "It is a violation of Federal law to use
this product in a manner inconsistent with its labeling."
This statement appears at the beginning of the directions
for use, directly beneath the heading of that section.
96
-------
Item 10A. REENTRY STATEMENT - If a reentry Interval
has been established by the Agency, it must be included on
the label. Additional worker protection statements may be
required in accordance with PR Notice 83-2, March 29, 1983.
Item 10B [There is no Item 10B].
Item IOC. STORAGE AND DISPOSAL BLOCK - All labels are
required to bear storage and disposal statements. These
statements are developed for specific containers, sizes, and
chemical content. These instructions must be grouped and
appear under the heading "Storage and Disposal" in the directions
for use. This heading must be set in the same type sizes as
required for the child hazard warning. Refer to Appendix
IV-4 to determine the disposal instructions appropriate for
your products.
Item 10D. DIRECTIONS FOR USE - Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. When followed, directions must be adequate to
protect the public from fraud and from personal injury and to
prevent unreasonable adverse effects on the environment. See
Appendix IV-1. [40 CPR 162.10]
B. Collateral Labeling
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, or other written or graphic printed matter which is
referred to on the label or which is to accompany the product
are termed collateral labeling. Such labeling may not bear
claims or representations that differ in substance from
those accepted in connection with registration of the product.
It should be made part of the response to this notice and
submitted for review.
-------
V- INSTRUCTIONS FOR SUBMISSION
A. For Manufacturing Products (MP) containing (metrlbuzin)
as an active ingredient.
1. Within 90 days from receipt of this document, you must
submit to the Product Manager in the Registration Division at
the address given at the end of this section the "PIPRA Section
3(c)(2)(B) Summary Sheet" EPA Form 8580-1. Refer to Appendix
II-3 with appropriate attachments.
If on the Summary Sheet, you commit to develop the data,
request a minor chemical exemption, present arguments that a
data requirement is not applicable, or submit protocols or modified
protocols for Agency review, you must also submit a copy of the
Summary Sheet (and any supporting information) to the Office of
Compliance Monitoring, which will be monitoring the data generated
in response to this notice. This information should be submitted
to the Office of Compliance Monitoring at the address given at
the end of this section. (Actual studies are not to be submitted.)
2. Within 6 months from receipt of this document you must
submit to the Product Manager on the Registration Division:
a. Confidential Statement of Formula, EPA Form 8570-4.
b. Product Specific Data Report, EPA Form 8580-4
(Appendix III-l).
c. Two copies of any required product-specific data.
d. Two copies of draft labeling, including the label and
associated brochures. If current labeling conforms to the
requirements of this guidance document and the results of
the short-term data, you may submit such labeling. End use
product labeling must comply specifically with the instructions
in Section I (Regulatory Position and Rationale) of this
guidance document. The labeling should be either typewritten
text on 8-1/2 x 11 inch paper or a mockup of the labeling
suitable for storage in 8-1/2 x 11 inch files. The draft
label must indicate the intended colors of the final label,
clear indication of the front panel label, and the intended
type sizes of the text.
e. Evidence of compliance with data support requirements
of PIPRA sec. 3(c)(l)(D). Refer to 40 CPR 152.80-152.99
(enclosed) for latest requirements.
93
-------
3. Within the times set forth In Table A, you must submit
to the Registration Division all generic data, unless you are
eligible for the formulator's exemption. If for any reason any
test is delayed or aborted so that the agreed schedule cannot be
met, notify the Product Manager and the Office of Compliance
Monitoring.
B. For Manufacturing Use Products containing (metribuzin)
in combination with other active ingredients
1. Within 90 days from receipt of this document, you must
submit the "PIPRA Section 3(c)(2)(B) Summary Sheet," EPA Form
8580-1. Refer to Appendix II-3 with appropriate attachments.
If on the Summary Sheet, you commit to develop the data,
request a minor chemical exemption, present arguments that a data
requirement is not applicable, or submit protocols or modified
protocols for Agency review, you must also submit a copy of the
Summary Sheet (and any supporting information) to the Office of
Compliance Monitoring, which will be monitoring the data generated
in response to this notice. This information should be submitted
to the Office of Compliance Monitoring at the address given at
the end of this section. (Actual studies are not to be submitted.)
2. Within the times set forth in Table A, you must submit
to the Registration Division all generic data, unless you are
eligible for the formulator's exemption. If for any reason any
test is delayed or aborted so that the agreed schedule cannot be
met, notify the Product Manager and the Office of Compliance
Monitoring.
C. For End Use Products containing (metribuzin))alone
or in combination with other active ingredients:
1. Within 90 days from receipt of this document, you must
submit the "PIPRA Section 3(c)(2)(B) Summary Sheet," EPA Form
8580-1. Refer to Appendix II-3 with appropriate attachments.
If on the Summary Sheet, you commit to develop the data,
request a minor chemical exemption, present arguments that a
data requirement is not applicable, or submit protocols or modified
protocols for Agency review, you must also submit a copy of the
Summary Sheet (and any supporting information) to the Office of
Compliance Monitoring, which will be monitoring the data generated
in response to this notice. This information should be submitted
to the Office of Compliance Monitoring at the address given at
the end of this section. (Actual studies are not to be submitted.)
99
-------
2. Within 6 months from receipt of this document you must
submit:
a. Confidential Statement of Formula, EPA Form 8570-4.
b. Product-Specific Data Report, EPA Form 8580-4
(Appendix III-l).
c. Two copies of any required product-specific data.
(Refer to Table C).
d. Two copies of draft labeling, including the label and
associated brochures. If current labeling conforms to the
requirements of this guidance document and the results of
the short-term data, you may submit such labeling. End use
product labeling must comply specifically with the instructions
in Section I (Regulatory Position and Rationale) of this
guidance document. Labeling should be either typewritten
text on 8 1/2 x 11 inch paper or a mockup of the labeling
suitable for storage in 8 1/2 inch files. The draft label
must indicate the intended colors of the final label, clear
indication of the front panel label, and the intended type
sizes of the text.
e. Evidence of compliance with data support requirements
of FIFRA sec. 3(c)(l)(D). Refer to 40 CFR 152.80-152.99
(enclosed) for latest requirements.
3. Within the time frames set forth in Table A, submit all
generic data, unless you are eligible for the formulator's
exemption.
D. For intrastate products containing (Metribuzln)
either as the sole active ingredient or in combination
with other active Ingredients
These products are being called in for full Federal
registration. Producers of these products are being sent
a letter instructing them how to submit an application for
registration.
E. Applications and other required information should be
submitted to the following address:
Robert Taylor, Product Manager
Registration Division (TS-767C)
Office of Pesticide Programs
Environmental Protection Agency
401 N St., S.W.
Washington, D.C. 20460
Phone No. (703) 557-1800
100
-------
The address for submission to the Office of Compliance Monitoring
is:
Laboratory Data Integrity Program
Office of Compliance Monitoring (EN-342)
Environmental Protection Agency
401 M St., S.W.
Washington, B.C. 20460
101
-------
Appendix II-l
Guide to Use of This Bibliography
CONTENT OP BIBLIOGRAPHY. This bibliography contains
citations of all studies considered relevant by EPA in
arriving at the positions and conclusions stated elsewhere
in the Standard. Primary sources for studies in this
bibliography have been the body of data submitted to EPA
and its predecessor agencies in support of past regulatory
decisions. Selections from other sources including the
published literature, in those instances where they have
been considered, will be included.
UNITS OP ENTRY. The unit of entry in this bibliography
is called a "study." In the case of published materials,
this corresponds closely to an article. In the case of
unpublished materials submitted to the Agency, the Agency
has sought to identify documents at a level parallel to
the published article from within the typically larger
volumes in which they were submitted. The resulting
"studies" generally have a distinct title (or at least a
single subject), can stand alone for purposes of review,
and can be described with a conventional bibliographic
citation. The Agency has attempted also to unite basic
documents and commentaries upon them, treating them as a
single study.
IDENTIFICATION OP ENTRIES. The entries in this bibliography
are sorted numerically by "Master Record Identifier," or
MRID, number. This number is unique to the citation, and
should be used at any time specific reference is required.
It is not related to the six-digit "Accession Number"
which has been used to identify volumes of submitted
studies; see paragraph 4(d)(4) below for a further explana-
tion. In a few cases, entries added to the bibliography
late in the review may be preceded by a nine-character
temporary identifier. These entries are listed after
all MRID entries. This temporary identifier number is
also to be used whenever specific reference is needed.
FORM OP ENTRY. In addition to the Master Record Identifier
(MRID), each entry''consists of a citation containing
standard elements followed, in the case of material
submitted to EPA, by a description of the earliest known
submission. Bibliographic conventions used reflect the
standards of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
102
-------
Appendix II-l (continued)
a. Author. Whenever the Agency could confidently Identify
one, the Agency has chosen to show a personal author.
When no individual was identified, the Agency has
shown an identifiable laboratory or testing facility
as author. As a last resort, the Agency has shown
the first submitter as author.
b. Document Date. When the date appears as four digits
with no question marks, the Agency took it directly
from the document. When a four-digit date is followed
by a question mark, the bibliographer deduced the
date from evidence in the document. When the date
appears as (19??), the Agency was unable to determine
or estimate the date of the document.
c. Title. In some cases, it has been necessary for
Agency bibliographers to create or enhance a document
title. Any such editorial insertions are contained
between square brackets.
d. Trailing Parentheses. For studies submitted to the
Agency in the past, the trailing parentheses include
(in addition to any self-explanatory text) the fol-
lowing elements describing the earliest known submission:
(1) Submission Date. The date of the earliest known
submission appears Immediately following the word
"received."
(2) Administrative Number. The next element,
immediately following the word "under," Is the
registration number, experimental use permit
number, petition number, or other administrative
number associated with the earliest known submission,
(3) Submitter. The third element is the submitter,
following the phrase "submitted by." When
authorship is defaulted to the submitter, this
element is omitted.
Volume Identification (Accession Numbers). The
final element in the trailing parentheses
Identifies the EPA accession number of the volume
in which the original submission of the study
appears. The six-digit accession number follows
the symbol "CDL," standing for "Company Data
Library." This accession number is in turn
followed by an alphabetic suffix which shows the
relative position of the study within the volume.
For example, within accession number 123^56, the
first study would be 123^56-A; the second, 123^56-
B; the 26th, 123^56-Z; and the 27th, 123^56-AA.
103
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MR ID CITATION
00015412 Analytical Biochemistry Laboratories (1976) Recovery of Sencor and
Metabolites from Soybeans: Report No. 51072. (Unpublished study
received Jan 19, 1977 under 100-583; prepared for Mobay Chemical
Corp., submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
095747-W)
00015414 Thornton, J.S. (1974) A Modified Gas Chromatographic Method for the
Determination of Sencor and Its Deaminated Diketo Metabolite in
Soybeans: Report No. 42232. Method dated Dec 4, 1974. (Unpub-
lished study received Jan 19, 1977 under 100-583; prepared by
Mobay Chemical Corp., submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:095748-V)
00015773 Searcy, S.; Herman, D.; Slagowski, J.L. (1978) Metolachlor
(Dual (R) 8E); Metribuzin (Sencor 50W); Paraquat (2C1): AG-A
No. 4894 1,11. (Unpublished study including letter dated
May 23, 1978 from J.D. Riggleman to Robert A. Kahrs, received
Mar 16, 1979 under 100-583; prepared in cooperation with E.I. du
Pont de Nemours £ Co., Inc. and Chevron Chemical Co., submitted
by Ciba-Geigy Corp., Greensboro, N.C.; CDL:237821-0)
00015949 Analytical Biochemistry Laboratories (1977) Chemagro Agricultural
Division--Mobay Chemical Corporation Residue Experiment: MW-HR-
409-75: Report No. 51071. (Unpublished study including report
nos. 51065, 51069 and 51070, received Jan 19, 1977 under 100-
583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
095747-AH)
00024503 Monsanto Company (1974) Summary of Residue Data. (Unpublished
study received Jan 16, 1978 under 524-285; CDL:232680-B)
00024737 Hilton, H.W.; Nomura, N.S.; Kameda, S.S.; et al. (1976) Some pat-
terns of herbicide and growth regulator intake, persistence, and
distribution in sugarcane. Archives of Environmental Contamina-
tion and Toxicology 4(4):385-394. (Also in unpublished submis-
sion received Jul 19, 1978 under 201-403; submitted by Shell
Chemical Co., Washington, D.C.; CDL:234470-AP)
00025729 Obrist, J.J.; Thornton, J.S. (1979) Soil Thin-Layer Mobility of
Baycor (TM), (R) Baytan, (R) Drydene and Peropal (TM). (Un-
published study received Dec 21, 1979 under 3125-EX-168; pre-
pared in cooperation with Agricultural Consultants, Inc.; sub-
mitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:099185-M)
IC4
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00026411 Mobay Chemical Corporation (1977) Residue Data for Sencor, Ala-
chlor in Potatoes. (Unpublished study received Jan 2, 1980 un-
der WA 79/88; prepared in cooperation with Analytical Biochemis-
try Laboratories, Inc., submitted by State of Washington for
Monsanto Co., Washington, D.C.; CDL:241541-A)
00028772 Atkins, E.L.; Greywood, E.A.; Macdonald, R.L. (1973) Toxicity of
Pesticides and Other Agricultural Chemicals to Honey Bees: Labo-
ratory Studies. Rev. By Univ. of California—Riverside, Dept.
of Entomology. Riverside, Calif.: UC, Agricultural Extension
Service. (Also in unpublished submission received Apr 2, 1980
under 464-556; submitted by Dow Chemical U.S.A., Midland, Mich.;
CDL:242149-Z)
00029800 Thornton, J.S.; Schumann, S.A.; Boughton, P.J.; et al. (1974) A Gas
Chromatographic Method for the Determination of Sencor and Its
Deaminated Diketo Metabolite in Soybeans. Rev. Method no.
30387 dated Apr 11, 1972. (Unpublished study received Dec 21,
1974 under 5G1580; prepared by Baychem Corp., submitted by
American Cyanamid Co., Princeton, N.J.; CDL:094331-J)
00029887 Thornton, J.S.; Hurley, J.B.; Obrist, J.J. (1976) Soil Thin-Layer
Mobility of Twenty Four Pesticides [sic] Chemicals: Report
No. 51016. (Unpublished study received Jan. 28, 1980 under
5F1547; submitted by Mobay Chemical Corp., Pittsburgh, Pa.; CDL:
099216-1)
00032428 Stanley, C.W.; Thornton, J.S. (1972) A Gas Chromatographic Method
for the Determination of Sencor and Metabolites in Sugarcane and
Products: Report No. 35115. Method dated Dec 7, 1972. (Unpub-
lished study received Jul 2, 1975 under 239-2186; submitted by
Chevron Chemical Co., Richmond, Calif.; CDL:119807-E)
00032429 Baychem Corporation (1973) Recovery of Sencor from Dry Soybeans:
Report No. 35413. (Unpublished study received Jul 2, 1975 under
239-2186; submitted by Chevron Chemical Co., Richmond, Calif.;
CDL:119807-F)
00034014 Edwards, D.F. (1978) Primary Skin Irritation and Sensitization
Tests on Guinea Pigs: Report No. 443-78. (Unpublished study re-
ceived Nov 20, 1978 under 352-390; submitted by E.I. du Pont de
Nemours & Co., Wilmington, Del.; CDL:236581-I)
105
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00035931 Find!ay, G.M.; Baker, S.R. (1972) Assessing the Environmental Haz-
ard of Pesticide Use: Report No. 37553. (Unpublished study re-
ceived Mar 7, 1975 under 5F1559; prepared by Univ. of Manitoba,
Dept. of Entomology, submitted by Mobay Chemical Corp., Kansas
City, Mo.; CDL:094871-0)
00036105 Murphy, J.J.; Jacobs, K.; Lamb, D.W. (1974) The Metabolism of Sen-
cor in a Dairy Cow: Report No. 40708. (Unpublished study re-
ceived Oct 10, 1974 under 5F1559; submitted by Mobay Chemical
Corp., Kansas City, Mo.; CDL:095130-B)
00036106 Bell, R.L.; Murphy, J.J. (1974) The Metabolism of Sencor in Chick-
ens: Report No. 40712. Rev. (Unpublished study received Oct
10, 1974 under 5F1559; submitted by Mobay Chemical Corp., Kan-
sas City, Mo.; CDL:095130-C)
00036107 Shaw, H.R., II; Murphy, J.J. (1974) The Metabolic Fate of 5-14C
Sencor in Pigs: Report No. 40768. (Unpublished study received
Oct 10, 1974 under 5F1559; submitted by Mobay Chemical Corp.,
Kansas City, Mo.; CDL:095130-D)
00036110 Thornton, J.S. (1974) Effect of Commercial Processing on Residues
of Sencor in Potatoes: Report No. 42341. (Unpublished study re-
ceived on unknown date under 5F1559; submitted by Mobay Chemical
Corp., Kansas City, Mo.; CDL:095987-B)
00036112 Simmons, C.E.; Gronberg, R.R. (1974) The Fate of Carbon-14-Labeled
Sencor in Potatoes Processed by Pan or French Frying: Report
No. 42452. (Unpublished study received on unknown date under
5F1559; submitted by Mobay Chemical Corp., Kansas City, Mo.;
CDL:095987-D)
00036216 Stanley, C.W. (1974) Comparison of Hydrolysis Methods for Sencor
from Alfalfa: Report No. 40977. (Unpublished study received on
unknown date under 4F1432; submitted by Chemagro Corp., Kansas
City, Mo.; CDL:095519-A)
00036219 Morgan, J.G. (1972) Preliminary Studies on the Metabolism of Sencor
in Tomatoes: Report No. 35013. (Unpublished study received Sep
27, 1973 under 4F1432; submitted by Chemagro Corp., Kansas City,
Mo.; CDL:095519-F)
lUb
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00036220 Morgan, J.G. (1973) Metabolism of Sencor in Tomatoes: Report
No. 35969. (Unpublished study received Sep 27, 1973 under
4F1432; submitted by Chemagro Corp., Kansas City, Mo.; CDL:
095519-G)
00036426 Chemagro Corporation (1974) Chemagro Division of Baychem Corpora-
tion Residue Experiment 661-4828-73H: Report No. 41349. (Unpub-
lished study including report nos. 41350 and 41351, received May
14, 1975 under 5F1628; prepared in cooperation with Cannon Lab-
oratories, CDL:094425-A)
00036427 Cannon Laboratories (1974) Recovery of Sencor and Dadk from Barley
and Wheat Grain: Report No. 41352. (Unpublished study received
May 14, 1975 under 5F1628; submitted by Mobay Chemical Corp.,
Kansas City, Mo.; CDL:094425-B)
00036428 Chemagro Corporation (1974) Chemagro Division of Baychem Corpora-
tion Residue Experiment 661-Extra-73D: Report No. 41353. (Un-
published study including report nos. 41354, 41355, 41356...,
received May 14, 1975 under 5F1628; prepared in cooperation with
Cannon Laboratories; CDL.-094425-C)
00036429 Morse Laboratories (1974) Chemagro Agricultural Division—Mobay
Chemical Corporation Residue Experiment 361-4701-73H: Report
No. 41820. (Unpublished study including report nos. 41822,
41823, 41824..., received May 14, 1975 under 5F1628; submitted
by Mobay Chemical Corp., Kansas City, Mo.; CDL:094425-D)
00036431 Sandie, F.E.; Gronberg, R.R. (1975) A Gas Chromatographic Method
for Determining Residues of Sencor and Metabolites in Animal
Tissues, Milk and Eggs: Report No. 42257. Method dated May 5,
1975. (Unpublished study received May 14, 1975 under 5F1628;
submitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:
094425-F)
00036432 Cannon Laboratories (1974) Recovery of Sencor from Barley and Wheat
Straw: Report No. 42292. (Unpublished study received May 14,
1975 under 5F1628; submitted by Mobay Chemical Corp., Kansas
City, Mo.; CDL:094425-G)
00036433 Mobay Chemical Corporation (1974) Recovery of Sencor and Metabo-
lites from Barley and Wheat Straw: Report No. 42293. (Unpub-
lished study received May 14, 1975 under 5F1628; CDL:094425-H)
107
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00036434 Mobay Chemical Corporation (1974) Raw Data and Chromatograms for
Analysis of Sencor and Dadk on Barley Straw: Report No. 42294.
(Unpublished study received May 14, 1975 under 5F1628; CDL:
094425-1)
00036435 Mobay Chemical Corporation (1974) Raw Data and Chromatograms for
Analysis of Sencor and Dadk on Wheat Straw: Report No. 42295.
(Unpublished study received May 14, 1975 under 5F1628; CDL:
094425-J)
00036436 Mobay Chemical Corporation (1974) Chemagro Agricultural Division—
Mobay Chemical Corporation Residue Experiment 661-47795-72H: Re-
port No. 42326. (Unpublished study including report no. 42328,
received May 14, 1975 under 5F1628; CDL:094425-K)
00036437 Mobay Chemical Corporation (1974) Chemagro Agricultural Division—
Mobay Chemical Corporation Residue Experiment 661-4779A-72H: Re-
port No. 42327. (Unpublished study including report nos. 42329,
42330 and 42332, received May 14, 1975 under 5F1628; CDL:
094425-L)
00036438 Mobay Chemical Corporation (1974) Chemagro Agricultural Division—
Mobay Chemical Corporation Residue Experiment 661-4714 Extra—
72H: Report No. 42331. (Unpublished study including report no.
42333, received May 14, 1975 under 5F1628; CDL:094425-M)
00036439 Mobay Chemical Corporation (1974) Chemagro Agricultural Division—
Mobay Chemical Corporation Residue Experiment 661-4832-73H: Re-
port No. 42350. (Unpublished study including report nos. 42351,
42352, 42353..., received May 14, 1975 under 5F1628; prepared in
cooperation with Cannon Laboratories; CDL:094425-N)
00036440 Mobay Chemical Corporation (1974) Chemagro Agricultural Division—
Mobay Chemical Corporation Residue Experiment 661-4822-73H: Re-
port No. 42363. (Unpublished study including report nos. 42364,
42365, 42366..., received May 14, 1975 under 5F1628; prepared in
cooperation with Cannon Laboratories; CDL:094425-0)
00036441 Mobay Chemical Corporation (1974) The Effect of Frozen Storage at 0
to -10°F on Sencor and Metabolite Residue in Milk: Report
No. 42372. (Unpublished study received May 14, 1975 under
5F1628; CDL:094425-P)
108
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00036443 Chemagro Corporation (1974) Chemagro Division of Baychem Corpora-
tion Residue Experiment 661-4710-73D: Report No. 40910. (Unpub-
lished study including report nos. 40911, 40912, 40913..., re-
ceived May 14, 1975 under 5F1628; prepared in cooperation with
Morse Laboratories, submitted by Mobay Chemical Corp., Kansas
City, Mo.; CDL:094424-C)
00036444 Mobay Chemical Corporation (1974) Raw Data and Chromatograms for
the Analysis of Sencor and DADK in Barley Grain: Report
No. 41237. Rev. (Unpublished study received May 14, 1975 under
5F1628; CDL:094424-D)
00036445 Cannon Laboratories (1974) Chemagro Division of Baychem Corporation
Residue Experiment: 263-4839-73H: Report No. 41339. (Unpub-
lished study including report nos. 41341, 41342, 41343..., re-
ceived May 14, 1975 under 5F1628; submitted by Mobay Chemical
Corp., Kansas City, Mo.; CDL:094424-E)
00036769 Mobay Chemical Corporation (1974) Chemagro Agricultural Division—
Mobay Chemical Corporation Residue Experiment 861-4708A-72D:
Report No. 42374. (Unpublished study including report nos.
42466, 42467, 42468..., received May 14, 1975 under 5F1628; CDL:
094426-B)
00036770 Mobay Chemical Corporation (1974) Chemagro Agricultural Division—
Mobay Chemical Corporation Residue Experiment: 861-4708 G-72H:
Report No. 42375. (Unpublished study received May 14, 1975 un-
der 5F1628; CDL:094426-C)
00036772 Mobay Chemical Corporation (1974) Chemagro Agricultural Division—
Mobay Chemical Corporation Residue Experiment AH-71A-851: Report
No. 42449. (Unpublished study received May 14, 1975 under
5F1628; CDL:094426-E)
00036776 Mobay Chemical Corporation (1974) Recovery of Sencor from Sainfoin:
Report No. 42470. .(Unpublished study received May 14, 1975 un-
der 5F1628; CDL:094426-I)
00036777 Mobay Chemical Corporation (1974) The Effect of Frozen Storage at
0 to -10°F on Sencor Residues in Green Alfalfa: Report
No. 42471. (Unpublished study received May 14, 1975 under
5F1628; CDL:094426-J)
1.09
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00036778 Mobay Chemical Corporation (1974) The Effect of Frozen Storage at
0 to -10°F on Sencor Residues in Poultry Tissues and Eggs: Re-
port No. 42451. (Unpublished study received May 14, 1975 under
5F1628; CDL:094426-K)
00036779 Mobay Chemical Corporation (1975) Chemagro Agricultural Division—
Mobay Chemical Corporation Residue Experiment 263-4701-72H: Re-
port No. 42484. (Unpublished study including report nos. 42485,
42486, 42487..., received May 14, 1975 under 5F1628; CDL:
094427-A)
00036780 Mobay Chemical Corporation (1974) Chemagro Agricultural Division—
Mobay Chemical Corporation Residue Experiment 661-4704 Extra-
72H: Report No. 42492. (Unpublished study received May 14, 1975
under 5F1628; CDL:094427-B)
00036781 Mobay Chemical Corporation (1974) Chemagro Agricultural Division—
Mobay Chemical Corporation Residue Experiment 661-4781-73H: Re-
port No. 42493. (Unpublished study including report nos. 42494,
42495 and 42496, received May 14, 1975 under 5F1628; CDL:
094427-C)
00036782 Morris, R.A. (1975) Interference Study for the Residue Method for .
Sencor and Its Metabolites in Various Crops: Report No. 42735.
(Unpublished study received May 14, 1975 under 5F1628; submitted
by Mobay Chemical Corp., Kansas City, Mo.; CDL:094427-D)
00037841 Chemagro Corporation (1974) Chemagro Division of Baychem Corpora-
tion Residue Experiment: 861-4723-73H: Report No. 40888. (Un-
published study including report no. 40889, received May 14,
1975 under 5F1628; submitted by Mobay Chemical Corp., Kansas
City, Mo.; CDL:094424-A)
00039525 American Cyanamid Company (1975) General Summary: Prowl Herbicide
and Its Metabolite and Sencor Residues in or on Potatoes. Sum-
mary of studies 095485-Q through 095485-S. (Unpublished study
received Feb 9, 1976 under 6G1739; CDL:095485-K)
00039530 Devine, J.M.; Thornton, J.S.; Stanley, C.W. (1975) Sencor (Bay
94337): The Gas Chromatographic Determination of Sencor 4-
Amino-6-t-butyl-3-(methylthio)-l,2,4-triazin-5(4H)-one from
Fortified Potatoes: Report No. C-767. Includes method, report
no. 33005, dated Apr 14, 1972. (Unpublished study received Feb
9, 1976 under 6G1739; prepared in cooperation with Chemagro
Corp., submitted by American Cyanamid Co., Princeton, N.J.; CDL:
095485-P)
110
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00039531 Devine, J.M.; Nzewi, G.I.; Boughton, P.J.; et al. (1975) Prowl (R)
(CL 92,553): Determination of CL 92,553 N-(l-Ethylpropyl)-3,4-
dimethyl-2,6-dinitrobenzenamide, CL 202,347 4-(l-Ethylpropyl
amino)-2-methyl-3,5-dinitro benzyl alcohol and Sencor 4-Amino-
6-t-butyl-3-(methylthio)-l,2,4-triazin-5(4H)-one Residues in
Potatoes: Report No. C-787. (Unpublished study received Feb 9,
1976 under 6G1739; submitted by American Cyanamid Co., Prince-
ton, N.J.; CDL:095485-Q)
00045255 Chemagro Corporation (1975) Supplement to Synopsis of the Effects
of Sencor on the Environment. Summary of studies 094871-C
through 094871-F, 094871-1 through 094871-0, 094871-Q through
094871-S. (Supplement no. 1; unpublished study received Mar 7,
1975 under 5F1559; submitted by Mobay Chemical Corp., Kansas
City, Mo.; CDL:094871-A)
00045256 Stanley, C.W.; Schumann, S.A. (1969) A Gas Chromatographic Method
for the Determination of Bay 94337 Residues in Potatoes, Soy-
beans, and Corn: Report No. 25,838. Method dated Oct 16, 1969.
(Unpublished study received Mar 7, 1975 under 5F1559; submitted
by Mobay Chemical Corp., Kansas City, Mo.; CDL:094871-B)
00045257 Robinson, R.A.; Gronberg, R.R.; Shaw, H.R., II (1970) Bay 94337 Me-
tabolism in Plants: Report No. 26,175. Rev. (Unpublished study
received Mar 7, 1975 under 5F1559; submitted by Mobay Chemical
Corp., Kansas City. Mo.; CDL:094871-C)
00045258 Gronberg, R.R.; Flint, D.R.; Shaw, H.R.; et al. (1971) The Metabo-
lism of Sencor (Bay 94337) in Soybean Plants: Report No. 29800.
(Unpublished study received Mar 7, 1975 under 5F1559; submitted
by Mobay Chemical Corp., Kansas City, Mo.; CDL:094871-D)
00045259 Khasawinah, A.M. (1972) The Metabolism of Sencor (Bay 94337) in
Soil: Report No. 31043. Rev. (Unpublished study received
Mar 7, 1975 under 5F1559; submitted by Mobay Chemical Corp.,
Kansas City, Mo.; CDL:094871-E)
00045260 Church, D.D.; Flint, D.R. (1973) The Metabolism of Sencor in Pota-
toes: Report No. 32047. Rev. (Unpublished study received
Mar 7, 1975 under 5F1559; submitted by Mobay Chemical Corp.,
Kansas City, Mo.; CDL:094871-F)
111
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00045262 Morgan, J.G.; Flint, D.R. (1972) Sencor Residues in Chicken Eggs
and Tissue: Report No. 33226. (Unpublished study received
Mar 7, 1975 under 5F1559; submitted by Mobay Chemical Corp.,
Kansas City, Mo.; CDL:094871-H)
00045263 Flint, D.R.; Shaw, H.R., II (1972) Residues in Tissue and Milk from
Goats Treated Daily with Sencor-14C in the Diet: Report
No. 33255. (Unpublished study received Mar 7, 1975 under
5F1559; submitted by Mobay Chemical Corp., Kansas City, Mo.;
CDL:094871-I)
00045268 Houseworth, L.D.; Tweedy, B.G. (1973) Report on Parent Leaching
Studies for (R) Sencor: Report No. 37180. (Unpublished study
received Mar 7, 1975 under 5F1559; prepared by Univ. of Mis-
souri, Dept. of Plant Pathology, submitted by Mobay Chemical
Corp., Kansas City, Mo.; CDL:094871-N)
00045275 Morgan, J.G. (1974) The Metabolism of Sencor in Seedling Potatoes:
Report No. 40564. (Unpublished study received Mar 7, 1975
under 5F1559; submitted by Mobay Chemical Corp., Kansas City,
Mo., CDL:094870-C)
00045278 Stanley, C.W.; Flint, D.R. (1974) The Metabolism of Sencor in
Alfalfa: Report No. 40853. (Unpublished study received Mar 7,
1975 under 5F1559; submitted by Mobay Chemical Corp., Kansas
City, Mo.; CDL:094870-I)
00045279 Hargroder, T.G.; Rogers, R.L. (1974) Behavior and fate of Metri-
buzin in soybean and hemp sesbania. Weed Science 22(3):238-245.
(Also in unpublished submission received Mar 7, 1975 under
5F1559; submitted by Mobay Chemical Corp., Kansas City, Mo.;
CDL:094870-J)
00045280 Schumacher, R.W. (1974) Metabolism of Metribuzin in Soybeans and
Soil: Report No. 40865. Doctoral dissertation, Univ. of Ken-
tucky. (Unpublished study received Mar 7, 1975 under 5F1559;
submitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:
094870-K)
00045282 Sandie, F.E.; Gronberg, R.R. (1974) A Gas Chromatographic Method
for Determining Residues of Sencor and Metabolites in Animal
Tissues, Milk and Eggs: Report No. 42257. Method dated Dec 5,
1974. (Unpublished study received Mar 7, 1975 under 5F1559;
submitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:
094870-M)
112
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00045283 Mobay Chemical Corporation (1974) Sencor Residues in Cattle:
Report No. 42373. (Unpublished study received Mar 7, 1975
under 5F1559; CDL:094870-N)
00045284 Mobay Chemical Corporation (1974) Sencor Residues in Poultry:
Report No. 42448. (Unpublished study received Mar 7, 1975
under 5F1559; CDL:094870-0)
00045286 Mobay Chemical Corporation (1974) Sencor Residues in Eggs: Report
No. 42450. (Unpublished study received Mar 7, 1975 under
5F1559; CDL:094870-Q)
00051482 Shellenberger, T.E. (1969) Letter sent to D.L. Nelson dated Aug 11,
1969: Toxicological evaluations of Bay 94337 with fish and wild-
life: GSRI Project No. NC-288; Letter Report No. 5; Report
No. 25527. (Unpublished study received Jan 16, 1970 under 3125-
EX-114; prepared by Gulf South Research Institute, submitted by
Mobay Chemical Corp., Kansas City, Mo.; CDL:222273-D)
00054354 Thornton, J.S.; Stanley, C.W. (1972) A Gas Chromatographic Method
for the Determination of Residues of Sencor and Its Metabolites
in Potatoes: Report No. 33U05. Method dated Apr 14, 1972. (Un-
published study received Aug 14, 1980 under 3125-314; submitted
by Mobay Chemical Corp., Kansas City, Mo.; CDL:243067-B)
00054355 Thornton, J.S. (1972) Effect of Room Temperature Storage on Resi-
dues of Sencor and Metabolites in Mature Potatoes: Report
No. 33058. (Unpublished study received Aug 14, 1980 under 3125-
314; submitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:
243067-C)
00054356 Mobay Chemical Corporation (1972) Effect of Frozen Storage at 0°F
on Sencor and DADK Residues in Soybeans: Report No. 33289. (Un-
published study received Aug 14, 1980 under 3125-314; CDL:
243067-D)
00054358 Mobay Chemical Corporation (1973) The Effect of Frozen Storage at
0 to -10°F on Sencor Residues in Potatoes: Report No. 35845.
(Unpublished study received Aug 14, 1980 under 3125-314; CDL:
243067-F)
00054360 Mobay Chemical Corporation (1974) The Effect of Frozen Storage at
0 to -10°F on Sencor Residues in Green Alfalfa: Report
No. 42471. (Unpublished study received Aug 14, 1980 under 3125-
314; CDL:243067-M)
113
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00054363 Mobay Chemical Corporation (1975) The Effect of Frozen Storage at
0 to -10°F on Sencor (TM) and Metabolite Residues in Green
Peas: Report No. 44621. (Unpublished study received Aug 14,
1980 under 3125-314; CDL:243067-P)
00054366 Mobay Chemical Corporation (1974) The Effect of Frozen Storage at
0 to -10°F on (R) Sencor Residues in Tomatoes: Report
No. 47371. (Unpublished study received Aug 14, 1980 under 3125-
314; CDL:243067-S)
00054368 Savage, K.E. (1976) Adsorption and mobility of Metribuzin in soil.
Weed Science 24(5):525-528. (Submitter report no. 51903; also
:in unpublished submission received Aug 14, 1980 under 3125-314
submitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:
243067-V)
00054369 Thornton, J.S.; Stanley, O.W. (1977) Gas chromatographic determina-
tion of Sencor and metabolites in crops and soil. Journal of
Agricultural and Food Chemistry 25(2):380-386. (Submitter re-
port no. 52909; also in unpublished submission received Aug 14,
1980 under 3125-314; submitted by Mobay Chemical Corp., Kansas
City, Mo.; CDL:243067-W)
00056362 Mobay Chemical Corporation (19??) Technical Information: Sencor.
(Unpublished study received Jan 23, 1976 under unknown admin.
no.; CDL:226026-A)
00061256 Smith, P.S.; Gordon, D.E. (1972) Report to Chemagro, a Division
of Baychem Corporation: 18-Month Carcinogenic Study with Sen-
cor (Bay 94337) in Swiss White Mice: IBT No. B9069; Report
No. 34481. (Unpublished study including report no. 34481a, re-
ceived on unknown date under 5F1559; prepared by Industrial
Bio-Test Laboratories, Inc., submitted by Mobay Chemical Corp.,
Kansas City, Mo.; CDL:094258-D)
00061260 Loser, E.; Mirea, D. (1974) Bay 94 337: Chronic Toxicity Studies
on Dogs (Two-Year Feeding Experiment): Report No. 4887; Report
No. 41814. (Unpublished study received on unknown date under
5F1559; prepared by Bayer, AG, submitted by Mobay Chemical
Corp., Kansas City, Mo.; CDL:094258-J)
114
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00064797 Wilson, G.R.; Baszis, S.R.; Steinmetz, J.R.; et al. (1980) Residues
of Acetochlor in Soybean and Corn Grain following Preemergent
Treatment with Acetochlor Alone or in Tank-mix Combinations
with Atrazine, Linuron and Metribuzin: Report No. MSL-1242.
Final rept. (Unpublished study received Dec 12, 1980 under
524-EX-56; submitted by Monsanto Co., Washington, D.C.; CDL:
099813-A)
00065507 Lamb, D.W.; Burke, M.A. (1977) Dietary Toxicity of (R) Sencor
Technical to Bobwhite Quail and Mallard Ducks: Report No. 51593.
(Unpublished study received Apr 13, 1977 under 3125-270; submit-
ted by Mobay Chemical Corp., Kansas City, Mo.; CDL:229312-A)
00067425 Monsanto Company (1980) Residues of Glyphosate and Other Herbicides
in Wheat following Chemical Fallow Applications of Roundup (R)
Tank Mix Combinations. Includes method dated Jul 1, 1979 and
undated methods entitled: 2,4-D in wheat forage, straw and
grain; Dicamba in wheat forage, straw and grain; Residues of
alachlor in wheat grain, forage and straw; Atrazine in wheat
forage, straw and grain; Cyanazine in wheat forage, straw and
grain; Metribuzin and metabolites in wheat forage, straw and
grain. (Unpublished study, including published data, received
Dec 29, 1980 under 524-308; CDL:243990-A; 243991)
00067433 Harrison, S.L.; Boros, E.J. (1980) Chloramben, Trifluralin & Metri-
buzin (+ DADK) Analyses of Soybeans Treated with Ami ben + Tref-
lan + Sencor or Lexone Tank Mix PPI: Project Report 10123/1280A.
(Unpublished study received Dec 19, 1980 under 264-138; prepared
in cooperation with Southern Illinois Univ., Plant & Soil Sci-
ence Dept. and others, submitted by Union Carbide Agricultural
Products Co., Inc., Ambler, Pa.; CDL:243984-F)
00069067 Thornton, J.S. (1974) A Gas Chromatographic Method for the Determi-
nation of Sencor and Metabolites in Various Crops: Report
No. 40901. Method dated Dec 11, 1974. (Unpublished study
received Sep 13, 1976 under 3125-277; submitted by Mobay Chemi-
cal Corp., Kansas City, Mo.; CDL:226759-H)
00078436 Wilson, G.R.; Dubelman, S. (1981) Residues of Alachlor in Potatoes
following Preemergent and Lay-by Treatment with Lasso (R) Alone
or in Tank-mix Combinations with Metribuzin: Report No. MSL-
1559. Final rept. (Unpublished study received Aug 7, 1981
under 1F2551; submitted by Monsanto Co., Washington, D.C.; CDL:
070279-A)
115
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MR ID CITATION
00078438 Stauffer Chemical Company (1980) Eptam 7-E + Metribuzin Tank Mix on
Potatoes: Summary of Crop Residue Data. (Compilation; unpub-
lished study received Jul 27, 1981 under 476-2154; CDL:245620-B)
00078942 Mobay Chemical Corporation (1981) Addition to Synopsis of Sencor
Residue Chemistry on Various Crops: Addition No. 6. (Compila-
tion; unpublished study received Jul 13, 1981 under 3125-314;
CDL:245572-A)
00078943 Mobay Chemical Corporation (1981) Addition to Synopsis of Sencor
Residue Chemistry on Various Crops: Addition No. 5. (Compila-
tion; unpublished study received Jul 13, 1981 under 3125-314;
CDL:245573-A)
00079527 Smith, P.S.; Gordon, D.E. (1972) Report to Chemagro, a Division of
Baychem Corporation: 18-month Carcinogenic Study with Sencor
(Bay 94337) in Swiss White Mice: IBT No. B9069; Report
No. 34481. (Unpublished study received Mar 13, 1973 under 3125-
EX-120; prepared by Industrial Bio-Test Laboratories, Inc., sub-
mitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:126999-B)
00086681 Mobay Chemical Corporation (1981) Addition to Synopsis of Sencor:
Residue Chemistry on Soybeans. Summary of studies 246225-B and
246225-C. (Compilation; unpublished study received Oct 29, 1981
under 3125-277; CDL:246225-A)
00086765 Machemer, L.; Lorke, D. (1974) Evaluation of the Mutagenic Poten-
tial of (R) Sencor in an in vivo Cytogenetic Study on Spermato-
gonia of Chinese Hamster: Report No. 4961; 43067. (Unpublished
study received Nov 3, 1981 under 3125-270; prepared by Bayer AG,
West Germany, submitted by Mobay Chemical Corp., Kansas City,
Mo.; CDL:246226-A)
00086766 Machemer, L.; Lorke, D. (1974) Evaluation of (R) Sencor for Muta-
genic Effects on the Mouse: Report No. 4942; 43068. (Unpub-
lished study received Nov 3, 1981 under 3125-270; prepared by
Bayer AG, West Germany, submitted by Mobay Chemical Corp.,
Kansas City, Mo.; CDL:246226-B)
00086767 Machemer, L.; Lorke, D. (1975) (R) Sencor: Dominant Lethal Study
on Male Mice To Test for Mutagenic Effects: Report No. 5523;
45023. (Unpublished study received Nov 3, 1981 under 3125-270;
prepared by Bayer AG, West Germany, submitted by Mobay Chemical
Corp., Kansas City, Mo.; CDL:246226-C)
116
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00086768 Machemer, L.; Lorke, D. (1976) (R) Sencor: Additional Dominant
Lethal Study on Male Mice To Test for Mutagenic Effects by an
Improved Method: Report No. 6110; 49068. (Unpublished study
received Nov 3, 1981 under 3125-270; prepared by Bayer AG, West
Germany, submitted by Mobay Chemical Corp., Kansas City, Mo.;
CDL:246226-D)
00086770 Inukai, H.; lyatomi, A. (1977) Bay 94337: Mutagenicity Test on
Bacterial Systems: Report No. 67; 54127. (Unpublished study
received Nov 3, 1981 under 3125-270; prepared by Nitokuno Agri-
cultural Chemicals Institute, Japan, submitted by Mobay Chemi-
cal Corp., Kansas City, Mo.; CDL:246226-F)
00087795 Hayes, R.H.; Lamb, D.W.; Mallicoat, D.R.; et al. (1981) Metribuzin
((R) Sencor) Oncogenicity Study in Mice: 80050. (Unpublished
study received Nov 23, 1981 under 3125-270; submitted by
Mobay Chemical Corp., Kansas City, Mo.; CDL:246397-A)
00087796 Unger, T.M.; Shellenberger, T.E. (1981) A Teratological Evaluation
of Sencor (R) in Mated Female Rabbits: 80051. Final rept.
(Unpublished study received Nov 23, 1981 under 3125-270; sub-
mitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:246397-B)
00087925 Mobay Chemical Corporation (1978) (R) Sencor Residue Chemistry on
Soybeans: Supplement No. 5. (Compilation; unpublished study
received Dec 16, 1981 under 3125-277; CDL:246510-A)
00087926 Mobay Chemical Corporation (1981) (R) Sencor Residue Chemistry on
Various Crops: Addition No. 7. (Compilation; unpublished study
received Dec 23, 1981 under 3125-277; CDL:246509-A)
00093409 Mobay Chemical Corporation (1978) Nitrosamines in Technical and
Formulated Products: Report No. 66197. (Compilation; unpub-
lished study received Jul 5, 1978 under 3125-50; CDL:234223-A)
00101537 Lauer, R.; Dubelman, S. (1982) Residues of Alachlor in Soybeans
Following Preemergent Treatment with Lasso ME Alone or in Tank-
mix Combinations with Roundup, Linuron and Metribuzin: Report
No. MSL 2084. (Unpublished study received May 10, 1982 under
524-344; submitted by Monsanto Co., Washington, DC; CDL:
070844-B)
117
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00105212 Frank, R.; Sieck, R.; Shuey, E. (1979) Oryzalin and Metribuzin
Residues in White Potatoes When Surface Applied to Control
Weeds. (Unpublished study received Jul 1, 1982 under 1471-96;
submitted by Elanco Products Co., Div. of Eli Lilly and Co.,
Indianapolis, IN; CDL:070954-A)
00106149 Crawford, C.; Anderson, R. (1972) The Acute Dermal Toxicity of
Sencor Technical and Sencor 50% Wettable Powder to Rats and
Rabbits: Report No. 33123. (Unpublished study received May 17,
1973. under 3125-270; submitted by Mobay Chemical Corp., Kansas
City, MO; CDL:051077-A)
00106158 Kimmerle, G.; Solecke, B.; Lorke (1969) Bay 94337 Toxicological
Studies from Dr. George Kimmerle, M.D. and Dr. Brigitte Solecke,
V.M.D.: Report No. 1574; 25942. (Unpublished study received Jul
3, 1971 under OG0940; prepared by Farbenfabriken Bayer, AG, W.
Ger., submitted by Mobay Chemical Corp., Kansas City, MO; CDL:
091606-1)
00106163 Mobay Chemical Corp. (1969) Bay 94337 Metabolic, Analytical, and
Residue Information on Potatoes and Soybeans. (Compilation;
unpublished study received Jan 16, 1970 under OG0940; CDL:
091607-A)
00106164 Mobay Chemical Corp. (1972) Sencor (Bay 94337) Metabolic, Analyti-
cal, and Residue Information on Soybeans. (Compilation; unpub-
lished study received Oct 5, 1972 under 2F1274; CDL:091806-A;
091807)
00106165 Thornton, J. (1973) Effect of Cooking (Steaming) on the Release of
Sencor Residues from Soybeans: Report No. 36826. (Unpublished
study received Oct 6, 1972 under 2F1274; submitted by Mobay
Chemical Corp., Kansas City, MO; CDL:091809-A)
00106168 Mobay Chemical Corp. (1973) Sencor: Metabolic, Analytical, and
Residue Information for Sugarcane (Hawaii). (Compilation;
unpublished study received Mar 30, 1973 under 4F1432; CDL:
093822-A; 093820)
00106169 Mobay Chemical Corp. (1972) Sencor (BAY 94337): Metabolic, Analyt-
ical, and Residue Information on Tomatoes. (Compilation; un-
published study received Apr 25, 1972 under 4F1432; CDL:
093821-A)
118
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00106173 Mobay Chemical Corp. (1975) Sencor: Analytical, Metabolic, and
Residue Information for Various Crops. (Compilation; unpub-
lished study received May 14, 1975 under 5F1628; CDL:094423-A)
00106179 Mobay Chemical Corp. (1975) Sencor ... Residue Chemistry on Lentils
and Peas: Document No. AS76-788. (Compilation; unpublished
study received Jun 29, 1976 under 3125-277; CDL:095551-A)
00106180 Mobay Chemical Corp. (1976) Addition No. 1 to Brochure Entitled:
Sencor: Residue Chemistry on Tomatoes: Document No. AS76-549.
(Compilation; unpublished study received May 6, 1976 under
6F1783; CDL:095907-A)
00106182 Mobay Chemical Corp. (1977) Sencor Residue Chemistry on Various
Crops: Addition No. 1 to Brochure Entitled: Sencor Analytical,
Metabolic, and Residue Information for Various Crops: Document
No. AS 77-1557. (Compilation; unpublished study received Sep
21, 1977 under 3125-277; CDL:096367-A)
00106183 Mobay Chemical Corp. (1977) Sencor Residue Chemistry on Soybeans:
Supplement No. 4 to Brochure Entitled: Sencor (Formerly Bay
94337) Metabolic, Analytical and Residue Information on Soy-
beans: Document No. AS 78-153. (Compilation; unpublished study
received Feb 13, 1978 under 3125-277; CDL:096820-A)
00106184 Kadoum, A.; Gronberg, R. (1978) Effect of Dry Milling and Gluten
Processing on Sencor and DADK Residues in Wheat Grain: Document
No. AS78-1271; Report No. 66113. (Unpublished study received
Jun 16, 1978 under 3125-277; prepared by Kansas State Univ.,
Dept. of Entomology, submitted by Mobay Chemical Corp., Kansas
City, MO; CDL:097164-A)
00106184 Kadoum, A.; Gronberg, R. (1978) Effect of Dry Milling and Gluten
Processing on Sencor and DADK Residues in Wheat Grain: Document
No. AS78-1271; Report No. 66113. (Unpublished study received
Jun 16, 1978 under 3125-277; prepared by Kansas State Univ.,
Dept. of Entomology, submitted by Mobay Chemical Corp., Kansas
City, MO; CDL:097164-A)
00106185 Mobay Chemical Corp. (1978) Sencor Residue Chemistry on Various
Crops: Addition No. 3 to Brochure Entitled: Sencor Analytical,
Metabolic and Residue Information for Various Crops: Document
No. AS78-1274. (Compilation; unpublished study received Jun 16,
1978 under 3125-277; CDL:097165-A)
119
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00106189 Hilton, H.; Nomura, N.; Yauger, W.; et al. (1973?) Absorption,
Translocation, and Metabolism of Metribuzin (BAY-94337) in
Sugarcane: 35166. (Unpublished study received Oct 8, 1975 under
4F1432; submitted by Chemagro Corp., Kansas City, MO; CDL:
098168-E)
00106190 Chemagro Corp. (1975) Residues of Sencor in Sugarcane. (Compi-
lation; unpublished study received Oct 8, 1975 under 4F1432;
CDL:098168-F)
00106191 Houseworth, L. (1979) Residues of Metolachlor and Metribuzin in
Potato Tubers Resulting from the Use of Metolachlor and Meto-
lachlor/Metribuzin Tank Mixes for Weed Control in Potato Cul-
ture: Report No.: ABR-79040. (Unpublished study received Apr
25, 1979 under 100-583; submitted by Ciba-Geigy Corp., Greens-
boro, NC; CDL:098227-A)
00106193 Thornton, J.; Schumann, S. (1971) A Gas Chromatographic Method for
the Determination of Sencor and Its Deaminated Diketo Metabolite
in Potatoes and Soybeans: Report No. 30387. (Unpublished study
received on unknown date under OG0940; submitted by Chemagro
Corp., Kansas City, MO; CDL:098576-A)
00106197 Heitmuller, T. (1975) Acute Toxicity of Sencor to Eastern Oysters
(Crassostrea virginica), Pink Shrimp (Penaeus duorarum), and
Fiddler Crabs (Uca pugilator): submitter 43851. (Unpublished
study received Aug 19, 1975 under 3125-294; prepared by Bion-
omics—EG & G, Inc., submitted by Mobay Chemical Corp., Kansas
City, MO; CDL:165011-A)
00106199 Mobay Chemical Corp. (1973) Sencor (Formerly BAY 94337): Metabolic,
Analytical, Residue, and Flavor Evaluation for Potatoes. (Com-
pilation; unpublished study received Mar 8, 1973 under 3125-EX-
120; CDL:127000-A; 127001)
00106202 Mobay Chemical Corp. (1976) Sencor: Residue Chemistry on Sugarcane:
Addition No. 2 to Brochure Entitled: Sencor: Metabolic, Analyt-
ical and Residue Information for Sugarcane (Hawaii): Document
No. AS76-1245. (Compilation; unpublished study received Sep 10,
1976 under 3125-277; CDL:226131-A)
-120
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
MRID CITATION
00106203 Mobay Chemical Corp. (1973) Addition No. 1 to Brochure Entitled:
Sencor: Residue Chemistry on Potatoes: Document No. AS77-47.
(Compilation; unpublished study received Jan 24, 1977 under
3125-277; CDL:228041-A)
00106205 Mobay Chemical Corp. (1973) Addition No. 2 to Brochure Entitled:
Sencor: Residue Chemistry on Potatoes. (Compilation; unpub-
lished study received Nov 30, 1977 under 3125-314; CDL:232357-A)
00106207 E.I. du Pont de Nemours & Co. (1977) Name, Chemical Identity and
Composition: Lexone DF Metribuzin Weed Killer. (Compilation;
unpublished study received Dec 20, 1977 under 352-EX-97; CDL:
232513-A)
00106211 Mobay Chemical Corp. (1978) Sencor Residue Chemistry on Various
Crops: Addition No. 2, Feb 3, 1978, to Brochure Entitled: Sencor
Analytical, Metabolic and Residue Information for Various Crops
(Dated January 23, 1975): Document No. AS78-1882. (Compilation;
unpublished study received Sep 11, 1978 under 3125-314; CDL:
235087-A)
00106212 Mobay Chemical Corp. (1978) Sencor Residue Chemistry on Tomatoes:
Addition No. 2, May 3, 1978, to Brochure Entitled: Sencor (Bay
94337) Metabolic, Analytical and Residue Information on Tomatoes
(Dated Apr 25, 1972): Document No. AS78-2011. (Compilation;
unpublished study received Oct 3, 1978 under 3125-314; CDL:
235319-A)
00106215 BASF Wyandotte Chemical Corp. (1978) Basalin Herbicide Amended
Registration: Basalin Tank Mixture and Sequential Application
with Metribuzin: Residue Chemistry—Part 03. (Compilation; un-
published study received Nov 8, 1978 under 7969-46; CDL:
235698-B)
00106797 American Cyanamid Co. (1978) Amounts of Residues of Prowl, Its
Metabolite (CL 202,347) Metribuzin (Sencor or Lexone) and Eptam
in or on Potatoes. (Compilation; unpublished study received
Oct 5, 1978 under 241-243; CDL:097433-A; 097434)
00134495 Nelson, D.; Roney, D. (1979) Acute Toxicity of Sencor Technical to
Daphnia magna: Report No. 67262. (Unpublished study received
Oct 31, 1983 under 3125-277; submitted by Mobay Chemical Corp.,
Kansas City, MO; CDL:072083-A)
121
-------
OFFICE OF PESTICIDE PROGRAM
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metribuzin Standard
GS0181-001
GS0181-002
GS0181-003
GS0181-004
GS0181-005
GS0181-006
GS0181-007
GS0181-008
GS0181-009
GS0181-010
Stephenson, G. ; McLeod J.; Phatak S. (1976)
Differential tolerance of tomato cultivars to metribuzin.
Weed Science 24(2)(March): 161-165.
Interregional Research Project No. 4 (1984) Metribuzin/
Carrots/PR-1431. Unpublished compilation. CDL:072711-A
Mobay Chemical Corp. (1983)
Report Nos. 82828 and 82829.
PP #2F2677.
[Sencor in soybeans]:
Unpublished amendment to
Makhijani, G. (1975) Letter sent to J. Cummings dated
July 18, 1975, in EPA Administrative Record for
PP #5F1559. 3p.
Makhijani, G. (1975) Letter sent to J. Cummings dated
September 14, 1975, in EPA Administrative Record for
PP"#5F1559 and 5F1628. 2p.
Mayes, J. (1973) Letters sent to B. Puma dated
January 16, 1973, in EPA Administrative Record for
PP #2F2174. 6p.
McMahon, B. (1974) Letter sent to W. Cox dated
October 31, 1974, in EPA Administrative Record for
PP #5F1559. 3p.
Lamb, D.W.; and Roney, D.J. (1972) Acute Toxicity
of Sencor to Fish. Report No. 33124. Prepared by
Chemagro Division Research and Development. EPA
Accession No. 255025.
Lamb, D.W.; and Jones, R.F. (1972) Acute Toxicity
of Sencor Technical to Bobwhite Quail and Mallard
Ducks, Report No. 33172. Prepared by Chemagro
Research and Development. EPA Accesion No. 255025.
Crawford, C.R.; and Anderson, R.H. (1972) The Skin
and Eye Irritation Properties of Sencor Technical and
50% Wettable Powder on Rabbits. Report No. 32862. Pre-
pared by Chemagro Division of Baychem Corporation,
Kansas City, Missouri EPA Accession No. 112032.
122
-------
OMB Approval No. 2000-0468 Appendix II-3
FIFRA SECTION 3(C)(2)(B) SUMMARY SHEET
EPA REGISTRATION NO.
PRODUCT NAME
APPLICANT'S NAME
DATE GUIDANCE DOCUMENT ISSUED
With respect to the requirement to submit "generic" data imposed by the FIFRA section 3(C)(2)(B) notice contained in the referenced
Guidance Document, I am responding in the following manner:
D1. I will submit data in a timely manner to satisfy the following requirements. If the test procedures I will use deviate from (or are not
specified in) the Registration Guidelines or the Protocols contained in the Reports of Expert Groups to the Chemicals Group, OECD
Chemicals Testing Programme, I enclose the protocols that I will use:
O 2. I have entered into an agreement with one or more other registrants under FIFRA section 3(C)(2)(B)(ii) to satisfy the following data
requirements. The tests, and any required protocols, will be submitted to EPA by:
NAME OF OTHER REGISTRANT
D 3. I enclose a completed "Certification of Attempt to Enter Into an Agreement with Other Registrants for Development of Data" with
respect to the following data requirements:
D 4. I request that you amend my registration by deleting the following uses (this option is not available to applicants for new products):
. I request voluntary cancellation of the registration of this product. (This option is not available to applicants for new products.)
REGISTRANT'S AUTHORIZED REPRESENTATIVE
SIGNATURE
1 9
DATE
EPA Form 8580-1 (10-82)
-------
Appendix II-4
OMB Approval No. 2000-0468 (Expires: 12-31-S3J
(To Qualify, certify ALL four items)
CERTIFICATION OF ATTEMPT TO ENTER
INTO AN AGREEMENT WITH OTHER REGISTRANTS
FOR DEVELOPMENT OF DATA
1. I am duly authorized to represent the following firm(s) who are subject to the require-
ments of a Notice under FIFRA Section 3(c)(2)(B) contained in a Guidance Document
to submit data concerning the active ingredient:
GUIDANCE DOCUMENT DATE
ACTIVE INGREDIENT
NAME OF FIRM
EPA COMPANY NUMBER
(This firm or group of firms is referred to below as "my firm".)
2. My firm is willing to develop and submit the data as required by that Notice, if necessary. However, my firm would prefer to enter
into an agreement with one or more other registrants to develop jointly, or to share in the cost of developing, the following required
items or data:
3. My firm has offered in writing to enter into such an agreement. Copies of the offers are attached. That offer was irrevocable and included an offer to be
bound by an arbitration decision under FIFRA Section 3(c)(2)(B)(iii) if final agreement on all terms could not be reached otherwise. This offer was made
to the following firm(s) on the following date(s):
NAME OF FIRM
DATE OF OFFER
However, none of those firm(s) accepted my offer.
\. My firm requests that EPA not suspend the registration(s) of my firm's product(s), if any of the firms named in paragraph (3) above
have agreed to submit the data listed in paragraph (2) above in accordance with the Notice. I understand EPA will promptly inform
me whether my firm must submit data to avoid suspension of its registration(s) under FIFRA Section 3(c)(2)(B). (This statement
does not apply to applicants for new products.) I give EPA permission to disclose this statement upon request.
TYPED NAME
SIGNATURE
129
DATE
-------
Appendix III-l
EPA Registration No.
PRODUCT SPECIFIC DATA REPORT
Guidance Document for_
Date
Registration
Guideline No.
§158.20
PRODUCT
CHEMISTRY
61-1
61-2
61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-10
63-11
63-12
Name of Test
Identity of
ingredients
Statement of
composition
Discussion of
formation of
ingredients
Preliminary
analysis
Certification of
limits
Analytical methods
for enforcement
limits
Color
Physical state
Odor
Melting point
Boiling point
Density, bulk-
density, or
specific gravity
Solubility
Vapor pressure
Dissociation
constant
Octanol/water
partition
coefficient
PH
Test not
required
for my
product
listed
above
(check
below)
I am complying with
data requirements by
Citing MRID#
Submit-
ting
Data
(At-
tached)
(For EPA Use Only)
Accession Numbers
Assigned
-------
Appendix III-l (continued)
Registration
Guideline No.
63-13
63-14
63-15
63-16
63-17
63-18
63-19
63-20
63-21
§158.135
TOXICOLOGY
81-1
81-2
81-3
81-4
81-5
81-6
Name of Test
Stability
Oxidizing/ reducing
reaction
Plamnability
Explodability
Storage stability
Viscosity
Miscibility
Corrosion
characteristics
Dielectric break-
down voltage
Acute oral LD-50,
rat
Acute dermal
LD-50
Acute Inhalation,
LC-50 rat
Primary eye
irritation, rabbit
Primary dermal
irritation
Dermal sensltiza-
tion
Test not
required
for my
product
listed
above
(check
below)
I am complying with
data requirements by
Citing MRID#
Submit-
ting
Data
(At-
tached)
(For EPA Use Only)
Accession Numbers
Assigned
126
-------
Appendix IV-1
Chapter I—Environmental Protection Agency
§ 162./0
obtained the data from anothe
firVi (identify); applicant copied dajj
from a publication; applicant obtained
a copy of the data from EPA).
(d\The applicant shall submit jfith
his application a statement that HPA,
in itsYvaluation of the properties/effi-
cacy, Vnd safety of the formulated
end-usa product, may not consid/r any
data as supporting the application,
except tne following data:
(1) Th\ data the applicant
mitted to\
this sectic
(2) OthJ
las sub-
?A under paragra/h (b) of
data pertaini
to the
safety of the product's acttfe ingredi-
ents, rathenthan to the safety of the
end-use proobct; and
(3) Existing tolerances, fcod additive
regulations, exemptions/ and other
clearances issved undev the Federal
Food, Drug, ann Cosmet/c Act.
(e) If the applicant Ipiows that any
item of data heXsubmltted under this
section was generated ey (or at the ex-
pense of) anotheApenon who original-
ly submitted the Via/a to EPA (or its
predecessor, USD\)/on or after Janu-
irt an application
ixperimental • use
it adding a new
itration, or for
the applicant
dataXsubmitter have
agreement on the
termsYpf payment of
lion that\ may be pay-
section
ith regard to approval
tion), the applicant shall
'A a statement that he
id to each sue* identified
submitter:
ication of the Applicant's
intent to Ipply for registratidyn, includ-
ing the proposed product:
(2) An/offer to pay the person com-
pensatif n, with regard to the tbproval
of the/application, to the extent re-
quired/by FIFRA sections 3(c\QXD)
and 3fcX2XD);
(3)/An identification of the ittm(s)
of d/ta to which the offer appliesA
An offer to commence negotia-
te ascertain the amount Vnd
of compensation to be paid;
ary 1, 1970, to sup]
for registration,
permit, or amend
use to an existing
reregistration
and the orig
reached writt
amount and il
any comper
able unde
of the appll
submit to
has furnisl;
original da
(1) A n<3
tioi
te:
(5) The applicant's name,
id telephone number.
adc
If the applicant's product fon-
taink any active ingredient other/han
thosX that are present solely because
of theV incorporation into the product,
duringXformulation, of one or more
other Ifcgistered pesticide /roducts
purchase^ from another /roducer,
then theVpplicant shall auo comply
with § 162)6-5 as to such a/tive ingre-
dient, and \he applicatio/ shall con-
tain an acknowledgment/hat for pur-
poses of FIFKA sectionyB(c)dXD) the
application relies on (and any result-
ing registratiorXshould' be regarded as
if it were based v> th/Administrator's
consideration of )\he/following data:
(1) All data subA/ted or specifically
cited by the appl^ant in support of
the registration;
(2) Each othe/iteAs of data in the
Agency's files w/ic.h:
(i) Concerns/he properties or effects
of any such amive ingredient; and
(ii) Is one hi the typesXpf data that
EPA would/equire to be submitted for
scientific r/view by EPA i\ the appli-
cant sought the initial registration,
under HIFRA Section 3(c&5) of a
product/with composition andk intend-
ed uses/identical to those proposed for
the applicant's product, under the
data/requirements in effect o\ the
date/ EPA approves the applicant's
praient application.
lakes. 3, 6, and 25 of FIFRA. is amen
/.S.C. 136«Me<7
(44 FR 27953, May 11.1979]
§ 162.10 Labeling requirement*.
(a) General—(1) Contents of the
label. Every pesticide products shall
bear a labelv containing the informa-
tion specified by the Act and the regu-
lations in this Part. The contents of a
label must show, clearly and promi-
nently the following:
(i) The name, brand, or trademark
under which the product is sold as pre-
scribed in paragraph (b) of this
section;
(ii) The name and address of the
producer, registrant, or person for
whom produced as prescribed in para-
graph (c) of this section;
(lii) The net contents as prescribed
in paragraph (d) of this section;
127
-------
§ 162.10
Title 40—Protection of Environment
(iv) The product registration
number as prescribed in paragraph (e)
of this section;
(v) The producing establishment
number as prescribed in paragraph (f)
of this section;
(vi) An ingredient statement as pre-
scribed in paragraph (g) of this
section;
(vii) Warning or precautionary state-
ments as prescribed in paragraph (h)
of this section;
(viii) The directions for use as pre-
scribed in paragraph (i) of this section;
and
(ix) The use classification(s) as pre-
scribed in paragraph (j) of this section.
(2) Prominence and legibility, (i) All
words, statements, graphic representa-
tions, designs or other information re-
quired on the labeling by the Act or
the regulations in this part must be
clearly legible to a person with normal
vision, and must be placed with such
conspicuousness (as compared with
other words, statements, designs, or
graphic matter on the labeling) and
expressed in such terms as to render it
likely to be read and understood by
the ordinary individual under custom-
ary conditions of purchase and use.
(ii) All required label text must:
(A) Be set in 6-point or larger .type;
(B) Appear on a clear contrasting
background; and
(C) Not be obscured or crowded.
(3) Language to be used. All required
label or labeling text shall appear in
the English language. However, the
Agency may require or the applicant
may propose additional text in other
languages as is considered necessary to
protect the public. When additional
text in another language is necessary,
all labeling requirements will be ap-
plied equally to both the English and
other-language versions of the label-
ing.
(4) Placement of Label—(1) General
The label shall appear on or be secure-
ly attached to the immediate contain-
er of the pesticide product. For pur-
poses of this Section, and the mis-
branding provisions of the Act, "se-
curely attached" shall mean that a
label can reasonably be expected to
remain affixed during the foreseeable
conditions and period of use. If the im-
mediate container is enclosed within a
wrapper or outside container through
which the label cannot be clearly read,
the label must also be securely at-
tached to such outside wrapper or con-
tainer, if it is a part of the package as
customarily distributed or sold.
(ii) Tank cars and other bulk con-
tainers—(A) Transportation. While a
pesticide product is in transit, the ap-
propriate provisions of 49 CFR Parts
170-189, concerning the transportation
of hazardous materials, and specifical-
ly those provisions concerning the la-
beling, marking and placarding of haz-
ardous materials and the vehicles car-
rying them, define the basic Federal
requirements. In addition, when any
registered pesticide product is trans-
ported in a tank car, tank truck or
other mobile or portable bulk contain-
er, a copy of the accepted label must
be attached to the shipping papers,
and left with the consignee at the time
of delivery.
(B) Storage. When pesticide prod-
ucts are stored in bulk containers,
whether mobile or stationary, which
remain in the custody of the user, a
copy of the label of labeling, including
all appropriate directions for use, shall
be securely attached to the container
in the immediaTe vicinity of the dis-
charge control valve.
(5) False or misleading statements.
Pursuant to section 2(q)(lXA) of the
Act, a pesticide or a device declared
subject to the Act pursuant to
§ 162.15, is misbranded if its labeling is
false or misleading in any particular
including both pesticidal and non-pes-
ticidal claims. Examples of statements
or representations in the labeling
which constitute misbranding include:
(i) A false' or misleading statement
concerning the composition of the
product;
(ii) A false or misleading statement
concerning the effectiveness of the
product as a pesticide or device;
(iii) A false or misleading statement
about the value of the product for
purposes other than as a pesticide or
device;
(iv) A false or misleading comparison
with other pesticides or devices;
(v) Any statement directly or indi-
rectly implying that the pesticide or
device is recommended or endorsed by
128
-------
Chapter I—Environmental Protection Agency
§ 162.10
any agency of the Federal Govern-
ment;
(vi) The name of a pesticide which
contains two or more principal active
ingredients if the name suggests one
or more but not all such principal
active ingredients even though the
names of the other ingredients are
stated elsewhere in the labeling;
(vii) A true statement used in such a
way as to give a false or misleading im-
pression to the purchaser;
(viii) Label disclaimers which negate
or detract from labeling statements re-
quired under the Act and these regula-
tions;
(ix) Claims as to the safety of the
pesticide or its ingredients, including
statements such as "safe," "nonpoison-
ous," "noninjurious," "harmless" or
"nontoxic to humans and pets" with
or without such a qualifying phrase as
"when used as' directed"; and
(x) Non-numerical and/or compara-
tive statements on the safety of the
product, including but not limited to:
(A) "Contains all natural ingredi-
ents";
(B) "Among the least toxic chemi-
cals known"
(C) "Pollution approved"
(6) Final printed labeling, (i) Except
as provided in paragraph (a)(6)(ii) of
this section, final printed labeling
must be submitted and accepted prior
to registration. However, final printed
labeling need not be submitted until
draft label texts have been provision-
ally accepted by the Agency.
(ii) Clearly legible reproductions or
photo reductions will be accepted for
unusual labels such as those silk-
screened directly onto glass or metal
containers or large bag or drum labels.
Such reproductions must be of micro-
film reproduction quality.
(b) Name, brand, or trademark. (1)
The name, brand, or trademark under
which the pesticide product is sold
shall appear on the front panel of the
label.
(2) No name, brand, or trademark
may appear on the label which:
(i) Is false or misleading, or
(ii) Has not been approved by the
Administrator through registration or
supplemental registration as an addi-
tional name pursuant to § 162.6(b)(4).
(c) Name and address of producer,
registrant, or person for whom pro-
duced. An unqualified name and ad-
dress given on the label shall be con-
sidered as the name and address of the
producer. If the registrant's name ap-
pears on the label and the registrant is
not the producer, or if the name of the
person for whom the pesticide was
produced appears on the label, it must
be qualified by appropriate wording
such as "Packed for * * *," "Distribut-
ed by • • V or "Sold by to show
that the name is not that of the pro-
ducer.
(d) Net weight or measure of con-
tents. (1) The net weight or measure
of content shall be exclusive of wrap-
pers or other materials and shall be
the average content unless explicitly
stated as a minimum quantity.
(2) If the pesticide is a liquid, the
net content statement shall be in
terms of liquid measure at 68° F (20'C)
and shall be expressed in conventional
American units of fluid ounces, pints,
quarts, and gallons.
(3) If the pesticide is solid or semiso-
lid, viscous or pressurized, or is a mix-
ture of liquid and solid, the net con-
tent statement shall be in terms of
weight expressed as avoirdupois
pounds and ounces.
(4) In all cases, net content shall be
stated in terms of the largest suitable
units, i.e., "1 pound 10 ounces" rather
than "26 ounces."
(5) In addition to the required units
specified, net content may be ex-
pressed in metric units.
(6) Variation above minimum con-
tent or around an average is permissi-
ble only to the extent that it repre-
sents deviation unavoidable in good
manufacturing practice. Variation
below a stated minimum is not permit-
ted. In no case shall the average con-
tent of the packages in a shipment fall
below the stated average content.
(e) Product registration number.
The registration number assigned to
the pesticide product at the time of
registration shall appear on the label,
preceded by the phrase "EPA Regis-
tration No.," or the phrase "EPA Reg.
No." The registration number shall be
set in type of a size and style similar to
other print on that part of the label
on which it appears and shall run par-
129
-------
§162.10
Title 40—Protection of Environment
allel to it. The registration number
and the required identifying phrase
shall not appear in such a manner as
to suggest or imply recommendation
or endorsement of the product by the
Agency.
(f) Producing establishments regis-
tration number. The producing estab-
lishment registration number preced-
ed by the phrase "EPA Est.", of the
final establishment at which the prod-
uct was produced may appear in any
suitable location on the label or imme-
diate container. It must appear on the
wrapper or outside container of the
package if the EPA establishment reg-
istration number on the immediate
container cannot be clearly read
through such wrapper or container.
(g) Ingredient statement—(I) Gener-
al The label of each pesticide product
must bear a statement which contains
the name and percentage by weight of
each active ingredient, the total per-
centage by weight of all inert ingredi-
ents; and if the pesticide contains ar-
senic in any form, a statement of the
percentages of total and water-soluble
arsenic calculated as elemental ar-
senic. The active ingredients must be
designated by the term "active ingredi-
ents" and the inert ingredients by the
term "inert ingredients," or the singu-
lar forms of these terms when appro-
priate. Both terms shall be in the
same type size, be aligned to the same
margin and be equally prominent. The
statement "Inert Ingredients, none" is
not required for pesticides which con-
tain 100 percent active ingredients.
Unless the Ingredient statement is a
complete analysis of the pesticide, the
term "analysis" shall not be used as a
heading for the Ingredient statement.
(2) Position of ingredient statement.
(1) The ingredient statement is nor-
mally required on the front panel of
the label. If there is an outside con-
tainer or wrapper through which the
ingredient statement cannot be clearly
read, the ingredient statement must
also appear on such outside container
or wrapper. If the size or form of the
package makes it impracticable to
place the ingredient statement on the
front panel of the label, permission
may be granted for the ingredient
statement to appear elsewhere.
(ii) The text of the ingredient state-
ment must run parallel with other
text on the panel on which it appears,
and must be clearly distinguishable
from and must not be placed in the
body of other text.
(3) Names to be used in ingredient
statement. The name used for each in-
gredient shall be the accepted
common name, if there is one, fol-
lowed by the chemical name. The
common name may be used alone only
if it is well known. If no common name
has been established, the chemical
name alone shall be used. In no case
will the use of a trademark or propri-
etary name be permitted unless such
name has been accepted as a common
name by the Administrator under the
authority of Section 25(c)(6).
(4) Statements of percentages. The
percentages of ingredients shall be
stated in terms 'of weight-to-weight.
The sum of percentages of the active
and the inert ingredients shall be 100.
Percentages shall not be expressed by
a range of values such as "22-25%." If
the uses of the pesticide product are
expressed as weight of active ingredi-
ent per unit area, a statement of the
weight of active ingredient per unit
volume of the pesticide formulation
shall also appear in the ingredient
statement.
(5) Accuracy of stated percentages.
The percentages given shall be as pre-
cise as possible reflecting good manu-
facturing practice. If there may be un-
avoidable variation between manufac-
turing batches, the value stated for
each active ingredient shall be the
lowest percentage which may be
present.
(6) Deterioration. Pesticides which
change in chemical composition sig-
nificantly must meet the following la-
beling requirements:
(i) In cases where it is determined
that a pesticide formulation changes
chemical composition significantly,
the product must bear the following
statement in a prominent position on
the label: "Not for sale or use after
[date]."
(li) The product must meet all label
claims up to the expiration time indi-
cated on the label.
(7) Inert ingredients. The Adminis-
trator may require the name of any
130
-------
Chapter I—Environmental Protection Agency
§ 162.10
inert ingredienUs) to be listed in the
ingredient statement if he determines
that such ingredient(s) may pose a
hazard to man or the environment.
(h) Warnings and precautionary
statements. Required warnings and
precautionary statements concerning
the general areas of toxicological
hazard including hazard to children,
environmental hazard, and physical or
chemical hazard fall into two groups;
those required on the front panel of
the labeling and those which may
appear elsewhere. Specific require-
ments concerning content, placement,
type size, and prominence are given
below.
(1) Required front panel statements.
With the exception of the child
hazard warning statement, the text re-
quired on the front panel of the label
is determined by the Toxicity Catego-
ry of the pesticide. The category is as-
signed on the basis of the highest
hazard shown by any of the indicators
in the table below:
Toxicity categories
Hazard indicators
Oral LD»
Inhalation 1C-
Dermal LDM
Eye effects
Skin effects
1
Up to and including 50
mg/kg.
Up to and including .2
mg/Hter.
Up to and including 200
mg/kg.
Corrosive; comeal
opacity not reversible
withm 7 days.
Corrosive
II
From SO thru 500 mg/kg..
From .2 thru 2 mg/liter
From 200 thru 2000
Comeal opacity
reversible within 7
days; irritation
persisting for 7 days.
Severe irritation at 72
hours.
Ill
From 500 thru 5000 mg/
kg.
From 2. Kvj X mg/liter...
From 2.000 thru 20.000....
No comeal opacity;
irritation reversible.
within 7 days.
Moderate irritation at 72
hours.
IV
Greater than 5000 mg/
kg.
Greater than 20 mg/liter.
Greater than 20.000.
No irritation.
Mild or slight irritation at
72 hours.
(i) Human hazard signal word—(A)
Toxicity Category I. All pesticide prod-
ucts meeting the criteria of Toxicity
Category I shall bear on the front
panel the signal word "Danger." In ad-
dition if the product was assigned to
Toxicity Category I on the basis of its
oral, inhalation or dermal toxicity (as
distinct from skin and eye local ef-
fects) the word "Poison" shall appear
in red on a background of distinctly
contrasting color and the skull and
crossbones shall appear in immediate
proximity to the word "poison."
(B) Toxicity Category II. All pesti-
cide products meeting the criteria of
Toxicity Category II shall bear on the
front panel the signal word "Warn-
ing."
(C) Toxicity Category III. All pesti-
cide products meeting the criteria of
Toxicity Category III shall bear on
the front panel the signal word "Cau-
tion."
(D) Toxicity Category IV. All pesti-
cide products meeting the criteria of
Toxicity Category IV shall bear on the
front panel the signal word "Caution."
(E) Use of signal words. Use of any
signal word(s) associated with a higher
Toxicity Category is not permitted
except when the Agency determines
that such labeling is necessary to pre-
vent unreasonable adverse effects on
man or the environment. In no case
shall more than one human hazard
signal word appear on the front panel
of a label.
(ii) Child hazard warning. Every pes-
ticide product label shall bear on the
front panel the statement "keep out of
reach of children." Only in cases
where the likelihood of contact with
children during distribution, market-
ing, storage or use is demonstrated by
the applicant, to be extremely remote,
or if the nature of the pesticide is such
that it is approved for use on infants
or small children, may the Administra-
tor waive this requirement.
(iii) Statement of practical treat-
ment—(A.) Toxicity Category I. A
statement of practical treatment (first
aid or other) shall appear on the front
panel of the label of all pesticides fall-
ing into Toxicity Category I on the
basis of oral, inhalation or dermal tox-
icity. The Agency may, however,
permit reasonable variations in the
131
-------
§ 162.10
Title 40—Protection of Environment
placement of the statement of practi-
cal treatment is some reference such
as "See statement of practical treat-
ment on back panel" appears on the
front panel near the word "Poison"
and the skull and crossbones.
(B) Other toxicity categories. The
statement of practical treatment is not
required on the front panel except as
described in paragraph (hXIXiiiXA) of
this section. The applicant may, how-
ever, include such a front panel state-
ment at his option. Statements of
practical treatment are, however, re-
quired elsewhere on the label in
accord with paragraph (h)(2) of this
section if they do not appear on the
front panel.
(iv) Placement and prominence. All
the require front panel warning state-
ments shall be grouped together on
the label, and shall appear with suffi-
cient prominence relative to other
front panel text and graphic material
to make them unlikely to be over-
looked under customary conditions of
purchase and use. The following table
shows the minimum type size require-
ments for the front panel warning
statements on various sizes of labels:
Points
Size of libel Iron) panel in square
inches
Required
signal
word, all
capitals
"Keep out
of reach of
Children
6 and under
Above £ to 10
Above to to 15..
Above 15 to 30..
Over 30
6 i
10 |
12
14
18
6
6
8
10
12
(2) Other required warnings and pre-
cautionary statements. The warnings
and precautionary statements as re-
quired below shall appear together on
the label under the general heading
"Precautionary Statements" and
under appropriate subheadings of
"Hazard to Humans and Domestic Ani-
mals," "Environmental Hazard" and
"Physical or Chemical Hazard."
(i) Hazard to humans and domestic
animals. (A) Where a hazard exists to
humans or domestic animals, precau-
tionary statements are required indi-
cating the particular hazard, the
route(s) of exposure and the precau-
tions to be taken to avoid accident,
injury or damage. The precautionary
paragraph shall be immediately pre-
ceded by the appropriate hazard signal
word.
(B) The following table depicts typi-
cal precautionary statements. These
statements must be modified or ex-
panded to reflect specific hazards.
Toxicity
category
Precautionary statements by toxicity category
Oral. Inhalation, or dermal toxicity
Skin and eye local effects
III
Fatal (poisonous) if swallowed (inhaled or absorbed
through skin]. Do not breathe vapor [dust or spray
mitt). Do not get In eyas, on skin, or on clothing
[Front panel statement of practical treatment re-
quired.].
May be fatal H swallowed [inhaled or absorbed
through the skin]. Do not breathe vapors [dual or'
spray mial]. Do not get in eyes, on skin, or on
doming, tAppropriate first aid statements required.].
Harmful if swallowed [Inhaled or absorbed through the
skin]. Avoid breathing vapors [dust or spray mist].
Avoid contact with skin [eyes or clothing]. [Appro-
priate firs! aid statement required.].
(No precautionary statements required.]
I Corrosive, causes eye and skin damage (or skin
irritation]. Do not get in eyes, on skin, or on
CtotntflQ. W04V QOQQItl Of i9G9 ftnlwd AHO fUOQtf
gloves when handling. Harmful or fatal if swallowed.
[Appropriate first aid statement required.]
Causes eye [and skin] irritation. Do not get in eyes,
on skin, or on clothing. Harmful if swallowed. lAp*
• propnate Ant aid statement required.]
Avoid contact with skin, eyes or doming. In cat* of
contact Immediately flush eyes or skin with plenty of
Get medical mention if irritation persists.
[No precautionary statements required.]
(11) Environmental hazards. Where a
hazard exists to non target organisms
excluding humans and domestic ani-
mals, precautionary statements are re-
quired stating the nature of the
hazard and the appropriate, precau-
tions to avoid potential accident,
injury or damage. Examples of the
hazard statements and the circum-
132
-------
§ 162.10
Title 40—Protection of Environment
placement of the statement of practi-
cal treatment is some reference such
as "See statement of practical treat-
ment on back panel" appears on the
front panel near the word "Poison"
and the skull and crossbones.
(B) Other toxicity categories. The
statement of practical treatment is not
required on the front panel except as
described in paragraph (hXIXiiiXA) of
this section. The applicant may, how-
ever, include such a front panel state-
ment at his option. Statements of
practical treatment are. however, re-
quired elsewhere on the label in
accord with paragraph (h)(2) of this
section if they do not appear on the
front panel.
(iv) Placement and prominence. All
the require front panel warning state-
ments shall be grouped together on
the label, and shall appear with suffi-
cient prominence relative to other
front panel text and graphic material
to make them unlikely to be over-
looked under customary conditions of
purchase and use. The following table
shows the minimum type size require-
ments for the front panel warning
statements on various sizes of labels:
Point*
Six* of label Irani pin* in
inche*
5 jnd under -
Above S to to
Above to to 18
Above IS to 30
Over 30 _
squv* Required
signal
word, all
capital*
8
10
18
1 14
1
"Keep out
of reach of
Children
6
8
8
10
18
(2) Other required warnings and pre-
cautionary statements. The warnings
and precautionary statements as re-
quired below shall appear together on
the label under the general heading
"Precautionary Statements" and
under appropriate subheadings of
"Hazard to Humans and Domestic Ani-
mals," "Environmental Hazard" and
"Physical or Chemical Hazard."
(i) Hazard to humans and domestic
animals. (A) Where a hazard exists to
humans or domestic animals, precau-
tionary statements are required indi-
cating the particular hazard, the
route
-------
Chapter I—Environmental Protection Agency
§ 162.10
stances under which they are required
follow:
(A) If a pesticide intended for put-
door use contains an active ingredient
with a mammalian acute oral LD,0 of
100 or less, the statement "This Pesti-
cide Is Toxic to Wildlife" is required.
(B) If a pesticide intended for put-
door use contains an active ingredient
with a fish acute LC« of 1 ppm or less,
the statement "This Pesticide is Toxic
to Fish" is required.
(C) If a pesticide intended for put-
door use contains an active ingredient
with an avian acute oral LOM of 100
mg/kg or less, or a subacute dietary
LCM of 500 ppm or less, the statement
"This Pesticide is Toxic to Wildlife" is
required.
(D) If either accident history or field
studies demonstrate that use of the
pesticide may result in fatality to
birds, fish or mammals, the statement
"This pesticide is extremely toxic to
wildlife (fish)" is required.
(E) For uses involving foliar applica-
tion to agricultural crops, forests, or
shade trees, or for mosquito abate-
ment treatments, pesticides toxic to
pollinating insects must bear appropri-
ate label cautions.
(F) For all outdoor uses other than
aquatic applications the label must
bear the caution "Keep out of lakes,
ponds or streams. Do not contaminate
water by cleaning of equipment or dis-
posal of wastes."
(iii) Physical or chemical hazards.
Warning statements on the flammabil-
ity or explosive characteristics of the
pesticide are required as follows:
Run pant
Required text
(A) PRtSSUHIZCD CONTAINCHS
Flesh pom al or Mow 20* F; if there it a flashback at Extr«mely flammable. ConMni* under pressure. Keep away
any VIM opening,
Flash point above arFandnotoverSO'Feriflfie
flam* extension is more than 18 in long al a distance
of 8 in from the (lame.
Aft other pressurized containers
fir*, spark*, and heated surfaces. Do not puncture or incinerate
container. Exposure to temperatures above 130* F may causa
bursting,
Flammable. Contants undar pressure. Kaap away from heal.
sparks, and opan flame. Do not punetura or incinerate container.
Exposure to temperatures above 130* F may cause bursting.
Contents under pressure. Oo not use or store near heal or open
fltfiio. Do not punctmt or iflonorvlv contavncr. Expovurv to
temperatures above 130* F may causa bursting.
(B) NONMf SSUWZED CONTAIN!**
Al or below 20'F..
Above 20* F and not over 80*- F
Above 80' F and not over 150- F
Extremely flammable. Keep away from fire, sparks, and heated
surfaces.
Flammable. Keep away from neat and open flame.
Oo not use or store near heat or open flame.
(i) Directions for Use—(1) General
requirements—(i) Adequacy and clar-
ity of directions. Directions for use
must be stated in terms which can be
easily read and understood by the
average person likely to use or to su-
pervise the use of the pesticide. When
followed, directions must be adequate
to protect the public from fraud and
from personal injury and to prevent
unreasonable adverse effects on the
environment.
(il) Placement of directions for use.
Directions may appear on any portion
of the label provided that they are
conspicuous enough to be easily read
by the user of the pesticide product.
Directions for use may appear on
printed or graphic matter which ac-
companies the pesticide provided that:
(A) If required by the Agency, such
printed or graphic matter is securely
attached to each package of the pesti-
cide, or placed within the outside
wrapper or bag;
(B) The label bears a reference to
the directions for use in accompanying
leaflets or circulars, such as "See di-
rections in the enclosed circular" and
(C) The Administrator determines
that it is not necessary for such direc-
tions to appear on the label.
(iii) Exceptions to requirement for
direction for use—(A) Detailed direc-
tions for use may be omitted from la-
beling of pesticides which are intended
134
-------
§ 162.10
Title 40—Protection of Environment
for use only by manufacturers of prod-
ucts other than pesticide products in
their regular manufacturing processes,
provided that:
(1) The label clearly shows that the
product is intended for use only in
manufacturing processes and specifies
the type(s) of products involved.
(2) Adequate information such as
technical data sheets or bulletins, is
available to the trade specifying the
type of product involved and its
proper use in manufacturing process-
es;
(J) The product will not come into
the hands of the general public except
after incorporation into finished prod-
ucts: and
(4) The Administrator determines
that such directions are not necessary
to prevent unreasonable adverse ef-
fects on man or the environment.
(B) Detailed directions for use may
be omitted from the labeling of pesti-
cide products for which sale is limited
to physicians, veterinarians, or drug-
gists, provided that:
(It The label clearly states that the
product is for use only by physicians
or veterinarians;
(2) The Administrator determines
that such directions are not necessary
to prevent unreasonable adverse ef-
fects on man or the environment; and
(J) The product is also a drug and
regulated under the provisions of the
Federal Food, Drug and Cosmetic Act.
(C) Detailed directions for use may
be omitted from the labeling of pesti-
cide products which are Intended for
use only by formulators in preparing
pesticides for sale to the public, pro-
vided that:
-------
APPENDIX IV-2
LABELING REQUIREMENTS OP THE FIFRA, AS AMENDED
ITEM
1
2
3
4
5
6A
6B
7
7A
7B
LABEL ELEMENT
Product name
Company name
and address
Net contents
EPA Reg. No.
EPA Est. No.
Ingredients
statement
Pounds/gallon
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where dosage
given as Ibs.
al/unit area
All products
All products
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
None
None
None
None
Front panel
Front panel
Front panel
Front panel
Front panel
PKEKEhnED
Center front
panel
Bottom front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel,
Immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the main
ingredients
statement
Above signal
word
Immediately
below child
hazard
^watting
COMMENTS
If registrant is not the producer, must
be qualified by "Packed for . . .,"
"Distributed by. . .," etc.
May be In metric units in addition to
U.S. units
Must be In similar type size and run
parallel to other type.
May appear on the container Instead of
the label.
Text must run parallel with other text
on the panel. -
All front panel precautionary statements
must be grouped together, preferably
blocked.
Note type size requirements.
Note type size requirements.
136,
-------
APPENDIX IV-2 (continued)
ITEM
1C
7D
7E
8
BA
8B
LABEL ELEMENT
Skull & cross-
bevies and word
POISON (In red)
Statement of
practical
treatment
Referral
statement
Side/back panel
precautionary
statements
Hazards to
humans and
domestic
anirals
Environmental
hazards
APPLICABILITY
OP REQUIREMENT
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxicity
All products
in Categories
I, II, and III
All products
where pre-
cautionary
labeling
appears on
other than
front panel.
All products
All products
in Categories
I, II, and III
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
Category I:
Front panel
unless refer-
ral statement
is used.
Others :
Grouped with
side panel
precautionary
statements .
Front panel
None
None
None
PhfKb'KhKED
Both in close
proximity to
signal word
Front panel
for all.
Top or side
of back panel
preceding
directions
for use
Same as above
Same as above
COMMENTS
Must be grouped under the headings in
8A, 8B, and 8C; preferably blocked.
Must be preceded by appropriate signal
word.
Environmental hazards include bee
caution where applicable.
137
-------
APPENDIX IV-2 (continued)
ITEM
8C
9A
9C
10A
IOC
10D
LABEL ELEMENT
Physical or
chemical
hazards
Restricted
block
Misuse
statement
Reentry
statement
Storage and
disposal block
Directions
for use
APPLICABILITY
OP REQUIREMENT
All pressurized
products, others
with flash
points under
150°P
All restricted
products
All products
All
cholinesterase
inhibitors
All products
All products
PLACEMENT ON LABEL
REQUIRED
None
Top center
of front
panel
Immediately
following
heading of
directions
for use
In the
directions
for use
In the
directions
for use
None
FKEK.&KKEU
Same as above
Preferably
blocked
Immediately
after misuse
statement
^mediately
before
specific
directions
for use or
at the end of
directions
for use
None
COMMENTS
Includes a statement of the terms of
restriction. The words "RESTRICTED USE
PESTICIDE" must be same type size as
signal word.
Must be set apart and clearly distin-
guishable from from other directions
for use.
May be in metric as well as U.S. units
138
-------
Appendix IV-3
PHYSICAL-CHEMICAL HAZARDS
Criteria
I. Pressurized Containers
A.
Flashpoint at or below
20°F; or if there is a
flashback at any valve
opening.
B,
Flashpoint above 20°F
and not over 80°F; or
if the flame extension
is more than 18 inches
long at a distance of
6 inches from the
valve opening.
ALL OTHER PRESSURIZED
CONTAINERS
II. Non-Pressurized Containers
A. Flashpoint at or below
20°F.
B. Flashpoint above 20°F
and not over 80°F.
C. Flashpoint over 80°F
and not over 150°F.
D. Flashpoint above
150°F.
Required Label Statement
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame. Do
not puncture or Incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
139
-------
Appendix IV-4
STORAGE AND DISPOSAL INSTRUCTIONS FOR PESTICIDES
All products are required to bear specific label instructions
about storage and disposal. Storage and disposal instructions
must be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need not include the heading
"STORAGE AND DISPOSAL." The STORAGE AND DISPOSAL heading
must appear in the minimum type size listed below:
Size of label
front panel in
square inches
Required type size
for the heading
STORAGE AND DISPOSAL
(all capitals)
10 and under 6 point
Above 10 to 15 8 point
Above 15 to 30 10 point
Over 30 12 point
Storage and disposal instructions must be set apart and
clearly distinguishable from other directions for use.
Blocking storage and disposal statements with a solid line is
suggested as a means of increasing their prominence.
A. Storage Instructions;
All product labels are required to have appropriate storage
instructions. Specific storage instructions are not prescribed,
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors:
1. Conditions of storage that might alter the composition or
usefulness of the pesticide. Examples could be temperature
extremes, excessive moisture or humidity, heat, sunlight,
friction, or contaminating substances or media.
2. Physical requirements of storage which might adversely
affect the container of the product and its ability to
continue to function properly. Requirements might Include
positioning of the container in storage, storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
3. Specifications for handling the pesticide con-Gainer,
including movement of container within the storage area,
proper opening and closing procedures (particularly for
opened containers), and measures to minimize exposure
while opening or closing container.
140
-------
3.
Appendix IV-4
(continued)
"Pesticide wastes are toxic. Improper disposal of excess
nesticide, spray mixture, or rinsate is a violation of
Federal Law. If these wastes cannot be disposed of by
use according to label instructions, contact your State
Pesticide or Environmental Control Agency, or the Hazardous
Waste representative at the nearest EPA Regional Office
for guidance."
Labels for all other products, except those intended for
domestic use, must bear the following pesticide disposal
statement:
"Wastes resulting from the use of this product may be
disposed of on site or at an approved waste disposal
facility."
Products intended for domestic use only must bear the
following disposal statement: "Securely wrap original
container in several layers of newspaper and discard in
trash."
C. Container Disposal Instructions
The label of each product must bear container disposal
instructions appropriate to the type of container.
1. All products intended for domestic use must bear one
of the following container disposal statements:
Container Type Statement
Non-aerosol products
(bottles, cansj Jars)
Non-aerosol products
(bags)
Aerosol products
Do not reuse container (bottle, can, Jar).
Rinse thoroughly before discarding in trash.
Do not reuse bag. Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or puncture.
141
-------
Appendix IV-4
(continued)
4. Instructions on what to do If the container Is damaged In
any way, or Jf the pesticide Is leaking or has been
spilled, and precautions to minimize exposure if damage occurs
5. General precautions concerning locked storage, storage in
original container only, and separation of pesticides
during storage to prevent cross-contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original container and placement in
locked storage areas.
B. Pesticide Disposal Instructions;
The label of all products, except those intended solely for
domestic use, must bear explicit instructions about pesticide
disposal. The statements listed below contain the exact wording
that must appear on the label of these products:
1. The labels of all products, except domestic use, must
contain the statement, "Do not contaminate water, food,
or feed by storage or disposal."
2. Except those products intended solely for domestic use,
the labels of all products that contain active ingredients
appearing on the "Acutely Hazardous" Commercial Pesticide
Products List (RCRA "E" List) at the end of this appendix
or are assigned to Toxicity Category I on the basis of
oral or dermal toxicity, skin or eye irritation potential,
or Toxicity Category I or II on the basis of acute inhala-
tion toxicity must bear the following pesticide disposal
statement:
"Pesticide wastes are acutely hazardous. Improper dis-
posal of excess pesticide, spray mixture, or rinsate is
a violation of Federal Law. If these wastes cannot be
disposed of by use according to label instructions,
contact your State Pesticide or Environmental Control
Agency, or the Hazardous Waste representative at the
nearest EPA Regional Office for guidance."
The labels of all products, except those intended for
domestic use, containing active or inert ingredients
that appear on the "Toxic" Commercial Pesticide Products
List (RCRA "P" List) at the end of this appendix or
presently meet any of the criteria in Subpart C, 40 CPR
261 for a hazardous waste must bear the following pesticide
disposal statement:
142
-------
Appendix IV
(continued)
2. The labels for all other products must bear container disposal
Instructions, based on container type, listed below:
Container Type Statement
Metal
containers
(non-aerosol)
Plastic containers
Glass containers
Fiber drums
with liners
Paper and
plastic bags
Compressed gas
cylinders
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or by
other procedures approved by state and local
authorities.
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or
Incineration, or, if allowed by state and
local authorities, by burning. If burned,
stay out of smoke.
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved state and local procedures.
Completely empty liner by shaking and
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reused1, dispose of in the same manner.
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out of smoke.
Return empty cylinder for reuse (or
similar wording)
Manufacturer may replace this phrase with one indicating
whether and how fiber drum may be reused.
143
-------
Appendix IV-4
(continued)
Pesticides that are hazardous wastes under 40 CPR 26l.33(e) and (f)
v;hon discarded.
"Acutely Hazardous" Commercial Pesticides (RCRA "E" List)
Active Ingredients, (no inerts);
Acrolein
Aldicarb
Aldrin
Allyl alcohol
Aluminum phosphide
4-Aminopyridine
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p-Chloroaniline
Cyanides (soluble cyanide salts, not specified elsewere)
Cyanogen chloride
2-Cyclohexyl-4,6-dinitrophenol
Dieldrin
0,0-Diethyl S-[2-ethylthio)ethyl] phosphorodithioate
(disulfoton, Di-Syston)
0,0-Diethyl 0-pyrazinyl phosphorothioate (Zinophos)
Dimethoate
0,0-Dimethyl 0-p-nitrophenyl phosphorothioate (methyl parathion)
4,6-Dinitro-o-cresol and salts
4,6-Dinitro-o-cyclohexylphenol
2,4 Dinitrophenol
Dinoseb
Endosulfan
Endothall
Endrin
Pamphur
Pluoroacetamide
Heptachlor
Hexanethyl tetraphosphate
Hydrocyanic acid
Hydrogen cyanide
Methorny1
alpha-Naphthylthiourea (ANTU)
Nicotine and salts
Octamethylpyrophosphoramide (OMPA, schradan)
Parathion
144
-------
Appendix IV-4
(continued)
"Acutely Hazardous" Commercial Pesticides (RCRA "E" List)
Active Ingredients continued;
Phenylmercuric acetate (PMA)
Phorate
Potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
Strychnine and salts
0,0,0,0-Tetraethyl dithiopyrophosphate (sulfotepp)
Tetraethyl pyrophosphate
Thallium sulfate
Thiofanox
Toxaphene
Warfarin
Zinc phosphide
145
-------
Appendix IV-4
(continued)
"Toxic" Commercial Pesticide Products (RCRA "F" Llstj
Active Ingredients;
Acetone
Acrylonitrile
Amitrole
Benzene
Bis(2-ethylhexyl)pthalate
Cacodylic acid
Carbon tetrachloride
Chloral (hydrate)
Chlordane (technical)
Chlorobenzene
4-Chloro-m-cresol
Chloroform
o-Chlorophenol
4-Chloro-o-toluidine hydrochloride
Creosote
Cresylic acid
Cyclohexane
Decachlorooctahydro-l,3,A-metheno-2H-cyclobuta[c,d]-pentalen-2-one
(kepone, chlordecone)
l,2-Dibromo-3-chloropropane (DBCP)
Dibutyl phthalate
S-3,3-(Dichloroallyl diisopropylthiocarbamate (diallate, Avadex)
o-Dichlorobenzene
p-Dichlorobenzene
Dichlorodifluoromethane (Preon 12*)
3,5-Dichloro-N-(l,l-dimethyl-2-propynyl) benzamide (pronamide,Kerb)
Dichloro diphenyl dichloroethane (DDD)
Dichloro diphenyl trichloroethane (DDT)
Dichlorethyl ether
2,4-Dichlorophenoxyacetic, esters and salts (2,4-D)
1,2-Dichloropropane
1,3-Dichloropropane (Telone)
Dimethyl phthalate
Ethyl acetate
Ethyl 4,4'-dichlorobenzilate (chlorobenzilate)
Ethylene dibromide (EDB)
Ethylene dichloride
Ethylene oxide
Formaldehyde
Furfural
Hexachlorobenzene
Hexachlorocyclopentadiene
Hexachloroethane
Hydrofluoric acid
146
-------
Appendix IV-4
(continued)
"Toxic" Commercial Pesticide Products (RCRA "P" List)
Active Ingredients;
Isobutyl alcohol
Lead acetate
Llndane
Malelc hydrazide
Mercury
Methyl alcohol
Methyl bromide
Methyl chloride
2,2'-Methylenebls (3,4,6-trichlorophenol) (hexachlorophene)
Methylene chloride
Methyl ethyl ketone
4-Methyl-2-pentanone (methyl isobutyl ketone)
Naphthalene
Nitrobenzene
p-Nitrophenol
Pentachloroethane
Pentachloronltrobenzene (PCNB)
Pentaclorophenol
Phenol
Phosphorodlthiolc acid, 0,0-diethyl, methyl ester
Propylene dlchlorlde
Pyrldine
Resorclnol
Safrole
Selenium dlsulflde
Sllvex
1,2,4,5-Tetrachlorobenzene
1,1,2,2-Tetrachloroethane
Tetrachloroethylene
2,3,4,6-Tetrachlorophenol
Thiram
Toluene
1,1,1-Trichloroethane
Trlchloroethylene
Trlchloromonofluoromethane (Preon 11 )
2,4,5-Trichlorophenol
2,4,6-Trichlorophenol
2,4,5-Trichlorophenoxyacetic acid (2,4,5-T)
Xylene
147
-------
Appendix IV-4
(continued)
"Toxic" Commercial Pesticide Products (RCRA "F" List)
Inert Ingredients;
Acetone
Acetonitrile
Acetophenone
Acrylic acid
Aniline
Benzene
Chlorobenzene
Chloroform
Cyclohexane
Cyclohexanone
Dichlorodifluoromethane (Preon 12*)
Diethyl phthalate
Dimethylamine
Dimethyl phthalate
1,4-Dioxane
Ethylene oxide
Formaldehyde
Formic acid
Isobutyl alcohol
Meleic anhydride
Methyl alcohol (methanol)
Methyl ethyl ketone
Methyl methacrylate
Naphthalene
Saccharin and salts
Thiourea
Toluene
1,1,1-Trichloroethane
1,1,2-Trichloroethane
Trichlorofluoromethane (Freon 11*)
Vinyl chloride
Xylene
6U.8. GOVERNMENT PRINTING OFFICE; 1 9 8 5 i»61 217 34920
148
------- |