xvEPA
            U ruted States
            Environmental Protection
            Agency
            Office of
            Pesticides and Toxic Substances
            Washington DC 20460
August 1981
            Pesticides
0,0-diethyl S-[(6-chloro-2-
oxobenzoxazolin-3-yl-)methyl]
phosphorodithioate
fPhosalone)
            Pesticide Registration
            Standard

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                     Phosalone
          Pesticide Registration Standard
Carol E. Langley
Ingrid M. Sunzenauer

William Boodee
Daniel Byrd
Dennis Edwards
Roger Gardner
Linda Garczynski
Steve Hopkins
John Jordan
Richard Lee
Rosalie Metzger
Allen Scheid
E. David Thomas
Les Touart
Phil Williams
Ralph Wright
Project Manager (SPRD)
Project Manager (SPRD)

Chemist (RCB/HED)
Science Advisor (HED)
Assistant Product Manager (RD)
Toxicologist (TB/HED)
Writer/Editor (SPRD)
Plant Physiologist  (EEB/HED)
Microbiologist (EFB/HED)
Entomologist (EEB/HED)
Chemist (RCB/HED)
Economist (EAB/BFSD)
Supervisory Entomologist (ASIB/BFSD)
Fisheries Biologist  (EEB/HED)
Management Analyst  (SPRD)
Project Manager (SPRD)
                August 21, 1981

    Office of Pesticides and Toxic Substances

         Environmental Protection Agency

               401 M Street, SW

            Washington, D.C.   20460

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Errata Sheet for Phosalone Pesticide Registration
Standard, Office of Pesticides and Toxic Substances,
Environmental Protection Agency, Washington, D.C., 20460,
August, 1981.

The changes are as follows:

Insert Table 1, page 55a.
Insert Table 2, Page 60a.

Delete the following two citations from the Office of
Pesticide Programs Registration Standard Bibliography
entitled "Citations Examined and Judged to be Inappropriate
for Use in Developing the Standard":

000006386 Desmoras, J.; Laurent, M., Terlain, B; Aublet,
J.C.; Sasmayoux, J.C.; Savary, M.  (1966) Study of the
Metabolism of Phosalone (11974 R.P.) in Plants: R.P.—D.S.
Ph. No. 11686. (Unpublished study received February 2, 1967
under 7G0575; prepared by Societe des Usines Chimiques
Rhone-Poulenc, submitted by Chipman Chemical Company, Inc.,
Burlingame, California; CDL; 090727-E)

000006674 Societe des Usines Chimiques Phone-Poulenc  (1968)
R.P.: Oxygen Analogue of Phosalone: Acute Oral Toxicity and
Anticholinesterasic Activity in Vitro: R.P.—D.S. Ph. No.
12644. (Unpublished study received June 14, 1968 under
8F0668; Submitted by Chipman Chemical Company, Inc.,
Burlingame, California, CDL: 091170-B)

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                      - TABLE OF CONTENTS -

                                                                 page
Chapter I     How to Register under a Registration Standard	2
Chapter II    Regulatory Position and Rationale	10
Chapter III   Summary of Data Requirements and Data Gaps	19
Chapter IV    Product Chemistry	41
Chapter V     Environmental Fate	46
Chapter VI    Toxicology	55
Chapter VII   Residue Chemistry	63
Chapter VIII  Ecological Effects	72
Bibliography	75

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CHAPTER I:  HOW TO REGISTER UNDER A REGISTRATION STANDARD

    A. Organization of the Standard
    B. Purpose of the Standard
    C. Requirement to Reregister Under the Standard
    D. "Product Specific" Data and "Generic" Data
    E. Data Compensation Requirements under FIFRA  3(c)(l)(D)
    F. Obtaining Data to Fill "Data Gaps"; FIFRA 3(c)(2)(B)
    G. Amendments to the Standard

A. Organization of the Standard

This  first chapter explains the purpose of a Registration Standard  and
summarizes the legal principles involved  in registering  or reregistering  under
a Standard. The second chapter involves the regulatory position  and the
rationale supporting this position. The third  chapter sets forth the data
requirements  that must be met to obtain or retain  registration for  products
covered by this particular Registration Standard.   In the remaining chapters,
the Agency reviews the available data by  scientific discipline,  discusses the
Agency's concerns with the identified potential hazards.

B. Purpose of the Standard

Section 3 of  the Federal Insecticide, Fungicide, and  Rodenticide Act (FIFRA)
provides that "no person in any State may distribute, sell, offer for sale,
hold  for sale, ship, deliver for shipment, or  receive (and having so received)
deliver or offer to deliver, to any person any pesticide which is not
registered with the Administrator  [of EPA]."   To approve the   registration of  a
pesticide, the Administrator must find, pursuant to Section 3(c)(5) that:

"1. its composition is such as to warrant the  proposed claims for it;

 2. its labeling and other material required to be submitted  comply
    with the  requirements of this Act;

 3. it will perform its intended function without  unreasonable adverse
    effects on the environment; and

 4. when used in accordance with widespread and commonly recognized
    practice  it will not generally cause  unreasonable adverse effects
    on the environment."

In making these findings, the Agency reviews a wide range of  data which
registrants are required to submit, and assesses the  risks and benefits
associated with the use of the proposed pesticide. However,  the established
approach to making these findings has been found to be defective on two  counts.

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 First,  EPA and  its  predecessor agency,  the United States Department of
 Agriculture (USDA),  routinely reviewed  registration applications on a "product
 by product" basis,  evaluating each product-specific application somewhat
 independently.   In  the  review of products containing similar components, there
 was little opportunity  for a retrospective review of the full range of
 pertinent data  available in Agency files and in the public literature.  Thus
 the "product by product" approach was often inefficient and sometimes resulted
 in inconsistent or  incomplete regulatory judgments.

 Second,  over the years,  as a result of  inevitable and continuing advances in
 scientific knowledge, methodology, and  policy,  the data base for many
 pesticides came to  be considered inadequate by  current scientific and
 regulatory standards.   Given the long history of pesticide regulation in
 several  agencies, it is even likely that materials may have been lost from
 the data files.   When EPA issued new requirements for registration in 1975 (40
 CFR 162) and proposed new guidelines for hazard testing in 1978 (43 FR 29686,
 July 10/1978 and 43 FR 37336,  August 22, 1978), many products that had already
 been registered for years were being sold and used without the same assurances
 of human and environmental safety as was being  required for new products.
 Because  of this inconsistency,  Congress directed EPA to reregister all
 previously registered products, so as to bring  their registrations and their
 data bases into compliance with current requirements [See FIFRA Section 3(g)].

 Facing  the enormous job of re-reviewing and calling-in new data for the
 approximately 35,000 current registrations, and realizing the inefficiencies of
 the "product by product" approach, the  Agency decided that a new, more
 effective method of review was needed.

 A new review procedure  has been developed.  Under it, EPA publishes documents
 called Registration Standards,  each of  which discusses a particular pesticide
 active  ingredient.   Each Registration Standard  summarizes all the data
 available to the Agency on a particular active  ingredient and its current uses,
 and sets forth  the  Agency's comprehensive position on the conditions and
 requirements for registration of all -existing and future products which contain
 that active ingredient.   These conditions and requirements, all of which must
 be  met to obtain or retain full registration or reregistration under Section
 3(c)(5)  of FIFRA, include the submission of needed scientific data which the
 Agency does not  now have,  compliance with standards of toxicity, composition,
 labeling,  and packaging,  and satisfaction of the data compensation provisions
 of  FIFRA Section 3(c)(l)(D).

 The  Standard will also  serve as a tool  for product classification.  As part of
 the  registration of  a pesticide product, EPA may classify each product for
 "general  use" or "restricted use" [FIFRA Section 3(d)].  A pesticide is
 classified  for  "restricted use" when some special regulatory restriction is
needed to ensure against unreasonable adverse effects to man or the
environment.  Many such  risks of unreasonable adverse effects can be lessened

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if expressly-designed label precautions are strictly  followed. Thus  the special
regulatory restriction for a "restricted use" pesticide  is usually a
requirement that it be applied only by, or under the  supervision of,  an
applicator who has been certified by the State or Federal government as being
competent to use the pesticide safely, responsibly, and  in accordance with
label directions.  A restricted-use pesticide can have other  regulatory
restrictions  [40 CFR 162.11(c)(5)] instead of, or in  addition to,  the certified
applicator requirement.  These other regulatory restrictions  may include such
actions as seasonal or regional limitations on use, or a requirement for the
monitoring of residue levels after use. A pesticide classified for "general
use," or not classified at all, is available for use  by  any individual who is
in compliance with State or local regulations.  The Registration Standard
review compares information about potential adverse effects of specific uses of
the pesticide with risk criteria listed in 40 CFR 162.11(c),  and thereby
determines whether a product needs to be classified for  "restricted  use."  If
the Standard does classify a pesticide for "restricted use,"  this  determination
is stated in the second chapter.

C. Requirement to Reregister Under the Standard

FIFRA Section 3(g), as amended in 1978, directs EPA to reregister  all currently
registered products as expeditiously as possible.  Congress also agreed that
reregistration should be accomplished by the use of Registration Standards.

Each registrant of a currently registered product to  which this Standard
applies, and who wishes to continue to sell or distribute his product in
commerce, must apply for reregistration.  His application must contain proposed
labeling that complies with this Standard.

EPA will issue a notice of intent to cancel the registration  of any  currently
registered product to which this Standard applies if  the registrant  fails to
comply with the procedures for reregistration set forth  in the Guidance Package
which accompanies this Standard.

D. "Product Specific" Data and "Generic" Data

In the course of developing this Standard, EPA has determined the  types of data
needed for evaluation of the properties and effects of products to which the
Standard applies, in the disciplinary areas of Product Chemistry,  Environmental
Fate, Toxicology, Residue Chemistry, and Ecological Effects.  These
determinations are based primarily on the data Guidelines proposed in 43 FR
29696, July 10, 1978; 43 FR 37336, August 22, 1978; and  45 FR 72948,
November 3, 1980, as applied to the use patterns of the  products to  which this
Standard applies.  Where it appeared that data from a normally applicable
Guidelines requirement was actually unnecessary to evaluate these  products, the
Standard indicates that the requirement has been waived.  On  the other hand, in
some cases studies not required by the Guidelines may be needed because of the
particular composition or use pattern of products the Standard covers; if so,

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the Standard explains the Agency's reasoning.  Data guidelines have not yet
been proposed for the Residue Chemistry discipline, but  the  requirements  for
such data have been in effect for some time and  are,  the Agency  believes,
relatively familiar to registrants.  Data which  we have  found are  needed  to
evaluate the registrability of some products covered  by  the  Standard  may  not be
needed for the evaluation of other products, depending upon  the  composition,
formulation type, and intended uses of the product in question.  The  Standard
states which data requirements apply to which product categories.   (See the
third chapter.)  The various kinds of data normally required for registration
of a pesticide product can be divided into two basic  groups:

1. Data that are product specific , i.e. data that relate  only
   to the properties or effects of a product with a particular
   composition  (or a group of products with closely similar
   composition); and

2. Generic data that pertain to the properties or effects  of a
   particular ingredient, and thus are relevant  to an evaluation of
   the risks and benefits of all products containing  that  ingredient
    (or all such products having a certain use pattern),  regardless
   of any such product's unique composition.

The Agency requires certain "product specific" data for  each product  to
characterize the product's particular composition and physical/chemical
properties  (Product Chemistry), and to characterize the  product's  acute
toxicity  (which is a function of its total composition).   The applicant for
registration or reregistration of any product, whether it  is a manufacturing-
use or end-use product, and without regard to its intended use pattern, must
submit or cite enough of this kind of data to allow EPA  to evaluate the
product.  For such purposes, "product specific"  data  on  any  product other than
the applicant's is irrelevant, unless the other  product  is closely similar in
composition to the applicant's.  (Where  it has been found  practicable to  group
similar products for purposes of evaluating, with a single set of  tests,  all
products in the group, the Standard so indicates.)  "Product specific" data  on
the efficacy of particular end-use products are  also  required where the exact
formulation may affect efficacy and where failure of  efficacy could cause
public health problems.

All other data needed to evaluate pesticide products  concern the properties  or
effects of a particular ingredient of products  (normally a pesticidally active
ingredient, but in some cases a pesticidally inactive, or  "inert",
ingredient).  Some data in this "generic" category are required  to evaluate  the
properties and effects of all products containing that ingredient  [e.g.,  the
acute LD-50 of the active ingredient in  its technical or purer grade; see
proposed guidelines, 43 FR 37355].

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Other "generic" data are required to evaluate all products which both contain a
particular ingredient and are intended  for certain  uses  (see,  e.g.,  proposed
guidelines,43 FR 37363, which requires  subchronic oral testing of the
active ingredient with respect to certain use patterns only).   Where a
particular data requirement  is use-pattern dependent, it will  apply to each end-
use product which is to be labeled  for  that  use pattern  (except where such end-
use product is formulated from a registered  manufacturing-use  product
permitting such formulations) and to each manufacturing-use  product with
labeling  that allows it to be used  to make end-use  products  with that use
pattern.  Thus, for example, a subchronic oral dosing study  is needed to
evaluate  the safety of any manufacturing-use product that  legally could be used
to make an end-use, food-crop pesticide.  But if an end-use  product's label
specified it was for use only in ways that involved no food/feed exposure and
no repeated human exposure,  the subchronic oral dosing study would not be
required  to evaluate the product's  safety; and if a manufacturing-use product's
label states that the product is for use only in making  end-use products not
involving food/feed use or repeated human exposure,  that subchronic oral study
would not be relevant to the evaluation of the manufacturing-use product either.

If a registrant of a currently registered manufacturing-use  or end-use product
wishes to avoid the costs of data compensation  [under FIFRA  Section 3(c)(l)(D)]
or data generation  [under Section 3(cj(2)(B)] for  "generic"  data that is
required only with respect to some  use  patterns, he may  elect  to delete those
use patterns from his labeling at the time he reregisters  his product.  An
applicant for registration of a new product  under  this Standard may similarly
request approval for only certain use patterns.

E. Data Compensation Requirements under FIFRA 3(c)(l)(D)

Under FIFRA Section 3(c)(l)(D), an  applicant for registration, reregistration,
or amended registration must offer  to pay compensation for certain existing
data the Agency has used in  developing  the Registration  Standard.   The data for
which compensation must be offered  are  all data which are described by all of
the following criteria:

1. The data were first submitted to EPA (or  to its  predecessor
   agencies, USDA or FDA), on or after  January 1,  1970;

2. The data were submitted to EPA  (or USDA or FDA)  by some other
   applicant or registrant in support of an  application  for  an
   experimental use permit,  an amendment adding a  new use  to a
   registration, or for registration, or to  support or maintain
   an existing registration;

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 3. They  are  the  kind  of  data which  are relevant to the Agency's
   decision  to register  or reregister the applicant's product
   under the Registration Standard,  taking into account the
   applicant's product's compositioa and  intended  use pattern(s);

 4. The Agency has  found  the data  to be valid  and usable in reaching
   regulatory conclusions; and

 5. They  are  not  data  for which the  applicant  has been exempted by
   FIFRA Section 3(c)(2)(D) from  the duty to  offer to pay
   compensation.   (This  exemption applies to  the "generic" data
   concerning the  safety of an active ingredient of the applicant's
   product,  not  to "product specific" data.   The exemption is
   available only  to  applicants whose product is labeled for end-
   uses  for  which  the active  ingredient in question is present in
   the applicant's product because  of his use of another registered
   product containing that active ingredient  which he purchases from
   another producer.

 An applicant for reregistration of  an already registered product under this
 Standard, or for registration of  a  new product under this Standard, accordingly
 must determine which  of  the data  used by  EPA  in developing the Standard must be
 the subject  of an  offer  to pay compensation,  and must submit with his
 application  the  appropriate statements evidencing  his compliance with FIFRA
 Section  3(c)(l)(D).

 An applicant would never be required to offer to pay for "product specific"
 data submitted by  another firm.   In many, if  not in most cases, data which are
 specific to  another firm's product  will not suffice to allow EPA to evaluate
 the applicant's  product,  that is, will not be useful to the Agency in
 determining  whether the  applicant's product is registrable.  There may be
 cases, however,  where because of  close similarities between the composition of
 two or more  products,  another firm's data may suffice to allow EPA to evaluate
 some or  all  of the "product specific" aspects of the applicant's product.  In
 such a case,  the applicant may choose to  cite that data instead of submitting
 data from tests  on his own product,  and if he chooses that option, he would
 have to  comply with the  offer-to-pay requirements  of Section 3(C)(1)(D) for
 that data.

 Each applicant for registration or  reregistration  of a manufacturing-use
product, and each  applicant for registration  or reregistration of an end-use
product, who  is not exempted by FIFRA Section 3(c)(2)(D), must comply with the
Section  3(c)(l)(D) requirements with respect  to each item of "generic" data
 that relates to his product's intended uses.

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A detailed description of the procedures an applicant must  follow in applying
for reregistration  (or new registration) under this Standard  is  found in the
Guidance Package for this Standard.

F. Obtaining Data to Fill "Data Gaps"; FIFRA  3(c)(2)(B)

Some of the kinds of data EPA needs for its evaluation of the properties and
effects of products to which this Standard applies have  never been submitted to
the Agency (or, if submitted, have been found to have deficiencies rendering
them inadequate for making registrability decisions) and have not been located
in the published literature search that EPA conducted as part of preparing  this
Standard.  Such instances of missing but required data are  referred to in the
Standard as "data gaps".

FIFRA Section 3(c)(2)(B), added to FIFRA by the Congress in 1978,  authorizes
EPA to require registrants to whom a data requirement applies to generate (or
otherwise produce) data to fill such "gaps" and submit those  data to EPA.  EPA
must allow a reasonably sufficient period for this to be accomplished.   If  a
registrant fails to take appropriate and timely steps to fill the data gaps
identified by a section 3(c)(2)(B) order, his product's  registration may be
suspended until the data are submitted.  A mechanism is  provided whereby two or
more registrants may agree to share in the costs of producing data for which
they are both responsible.

The Standard lists, in the third chapter, the "generic"  data  gaps and notes the
classes of products to which these data gaps pertain.  The  Standard also points
out that to be registrable under the Standard, a product must be supported  by
certain required "product specific" data.  In some cases, the Agency may
possess sufficient  "product specific" data on one currently registered product,
but may lack such data on another.  Only those Standards which apply to a very
small number of currently registered products will attempt  to state
definitively the "product specific" data gaps on a "product by product"
basis.  (Although the Standard will in some cases note which  data that EPA  does
possess would suffice to satisfy certain "product specific" data requirements
for a category of products with closely similar composition characteristics.)

As part of the process of reregistering currently registered  products,  EPA  will
issue Section 3(c)(2)(B) directives requiring the registrants to take
appropriate steps to fill all identified data gaps — whether the data in
question are "product specific" or "generic"  — in accordance with a schedule.

Persons who wish to obtain registrations for  new products under  this Standard
will be required to submit (or cite) sufficient "product specific" data before
their applications are approved.  Upon registration, they will be required
under Section 3(c)(2)(B) to take appropriate  steps to submit  data needed to

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fill "generic" data gaps.   (We expect  they will  respond  to this requirement by
entering  into cost-sharing  agreements  with other registrants who previously
have been told they must furnish  the data.)  The'Guidance Package for this
Standard  details the  steps  that must be  taken  by registrants to comply with
Section 3(c)(2)(B).

G. Amendments to the  Standard

Applications for registration which propose  uses or formulations that are not
presently covered by  the Standard, or  which  present product compositions,
product chemistry data, hazard data, toxicity  levels,  or labeling that do not
meet the  requirements of the Standard, will  automatically be considered by the
Agency to be requests for amendments to  the  Standard.   In response to such
applications, the Agency may request additional  data to  support the proposed
amendment to the Standard,  or may deny the application for registration on the
grounds that the proposed product would  cause  unreasonable adverse effects to
the environment.  In  the former case,  when additional  data have been
satisfactorily supplied, and providing that  the  data do  not indicate the
potential for unreasonable  adverse effects,  the  Agency will then amend the
Standard  to cover the new registration.

Each Registration Standard  is based upon all data and  information available to
the Agency's reviewers on a particular date  prior to the publication date.
This "cut-off" date is stated at  the beginning of the  second chapter.  Any
subsequent data submissions and any approved amendments  will be incorporated
into the  Registration Standard by means  of addenda,  which are available for
inspection at EPA in  Washington,  D.C., or copies of which may be requested from
the Agency.  When all the present "data  gaps"  have been  filled and the
submitted data have been reviewed, the Agency  will revise the Registration
Standard.  Thereafter, when the Agency determines that the internally
maintained addenda have significantly  altered  the conditions for registration
under the Standard, the document  will  be updated and re-issued.

While the Registration Standard discusses only the uses  and hazards of products
containing the designated active  ingredient(s),  the Agency is also concerned
with the  potential hazards  of some inert ingredients and impurities.
Independent of the development of any  one Standard,  the  Agency has initiated
the evaluation of some inert pesticide ingredients.  Where the Agency has
identified inert ingredients of concern  in a specific  product to which the
Standard applies, these ingredients will be  pointed out  in the Guidance Package.

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CHAPTER II:  REGULATORY POSITION AND RATIONALE

    A. Introduction
    B. Description of Chemical
    C. Regulatory Position
    D. Regulatory Rationale
    E. Criteria for Registration under the Standard
    F. Required Labeling
    G. Tolerance Reassessment

A. Introduction

This chapter presents the Agency's regulatory position  and  rationale based on
an evaluation of all registered products containing phosalone  as the sole
active ingredient. After briefly describing  the chemical, this chapter presents
the regulatory position and rationale, the criteria by  which applicants for
registration of phosalone products will be approved, labeling  considerations,
and tolerance reassessment. A summary of data requirements  is  contained in
Chapter III.  A discussion of the data upon  which  this  regulatory position is
based is presented within the disciplinary chapters, IV through VIII.   Also
considered  in this standard are Special Local Need (SLN)  registrations, which
are issued  by a State in accordance with FIFRA section  24 (c).   Valid State
registrations will be subject to rereg istration under the EPA  Registration
Standard System, in the same manner as a registration issued under section 3 of
FIFRA.  Currently such a registration has been granted  to California for the
application by aircraft to almonds, grapes,  stone  fruits  and walnuts.

B. Description of Chemical

Phosalone  (0,0-diethyl S-[(6-chloro-2-oxobenzoxazolin-3-yl-)methyl]
phosphorodithioate) is registered as an insecticide and miticide for use on a
variety of  fruit, nut, vegetable and ornamental crops.  The Chemical Abstracts
Service (CAS) Registry number is 2310-17-10.  The  OPP Internal Control Number
(EPA Shaughnessy number) is 097701.

The structural formula is:
                                     P-S-CH  -N — C
                             C-Hr-0           I    II

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C. Regulatory Position

Phosalone as described  in this  Standard may be  registered for
sale, distribution, reformulation  and  use  in the  United  States and its
territories.  The Agency has considered the scientific data obtained from
the open literature as  of July  I,  1981, and those data submitted by the
registrants up through  the time of publication  of this Standard.  Based upon
the review of these data, the Agency finds that none  of  the risk
criteria found in section 162.11 (a) of Title 40 of the U.S.  Code of Federal
Regulations were met or exceeded for phosalone. The Agency has determined that
phosalone has not been  demonstrated to cause unreasonable adverse effects, to
either man or the environment,  when used in accordance with prescribed label
directions and precautions. Phosalone  products  currently registered may be
reregistered subject to the conditions imposed  by this chapter, and to the data
requirements identified in Chapter III.  New products may be registered under
this  Standard and are subject to the same  requirements.

D. Regulatory Rationale

The Agency has reviewed data on phosalone  concerning  toxicology, ecological
effects, residue and product chemistry, and environmental fate.  The
toxicological effects data base is reasonably complete,  except for acute
inhalation toxicity, primary dermal irritation, primary  eye irritation, dermal
sensitization, subchronic 21-day dermal, and acute delayed neurotoxicity data
for the manufacturing-use product.  Primary dermal irritation and dermal
sensitization data are  still needed for the end-use products.   Data are also
still needed for primary eye irritation for the wettable powder formulation.
The residue chemistry data base is complete.    There  are some gaps in the data
base  for product chemistry, and environmental fate.   Much of the data base is
missing for ecological  effects.  Because there  are no registered public health
related uses, the Agency has waived the need for  efficacy data to support the
uses of phosalone. Despite the  existing data gaps, the Agency has concluded
that  the registration for this  chemical should  continue  for the following
reasons:

1. No valid, adverse effects data  of regulatory concern  have been revealed
   in the review of the studies made available  to the Agency.   The Agency*
   therefore, has concluded that the known risks, as  mitigated by product
   labeling, do not warrant any immediate  adverse regulatory action.

2. Although phosalone has been  implicated  in a  few poisoning incidents, the
   data do not conclusively indicate any hazards  associated with
   the normal use of phosalone.

   a.   The Pesticide Incidence  Monitoring  System  (PIMS report) lists 12
       incidents involving phosalone.  However, eleven of these incidents
       could  not conclusively implicate phosalone, because of excessive
       alcohol  consumption,  improper use of safety equipment,  failure to
                                       10

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       follow recommended safety regulations, and other reasons.   The one
       valid incident was isolated and did not  indicate a  consistent
       pattern of hazard associated with the recommended use  of  phosalone.

   b.  In 1973 there was a significant illness  episode in  Fowler,  California
       involving 32 pickers, who harvested grapes more than one  month after
       the application of phosalone, ethion, Imidan and dialifor.   Although
       phosalone might have caused the cholinesterase inhibition symptoms,
       it is also important to consider the possibility of interactive
       potentiation, since these workers were exposed to more than one
       pesticide.  Therefore, phosalone per se  cannot be implicated as the
       sole cause of the symptoms  (Maddy, K.T., 1976, MRID 005001833).

   c.  Another illness episode occurred in a vineyard near Madera,
       California.  Cholinesterase depression and cholinergic symptoms were
       reported among 118 field workers harvesting grapes, which had been
       treated with dialifor and phosalone between 15 and  40  days  earlier.
       The conclusion of this study indicates that the 21-fold difference in
       the toxicity of the two chemicals indicates that the effects were
       probably produced by dialifor and not by phosalone  (Knaak et al.,
       1978, MRID 005003635).

3. In accordance with FIFRA, the Agency's policy is not to cancel  or to
   withhold registration merely for the lack of data.  (See Sections
   3(c)(2)(B) and 3(c)(7) of FIFRA.)  Rather, publication  of  the Standard
   provides a mechanism for identifying data needs, and registration under
   the Standard allows for upgrading of labels  during the  period in which
   the required data are being generated.  When these data are received,
   they will be reviewed by the Agency.  The Agency will then determine
   whether these data will affect the registration of this chemical.

E. Criteria for Registration Under The Standard

To be subject to this Standard, products must meet the following conditions:

   - contain phosalone as the sole active ingredient,

   - bear required labeling, and

   - conform to the product composition standard, acute toxicity limits,  and
     use pattern requirements as discussed in the Manufacturing-Use and End-Use
     Product sections, which follow.

The applicant for registration or reregistration of products  subject to this
Standard must comply with all terms and conditions described  in  this Standard,
including a commitment to fill data gaps on a time schedule specified by  the
Agency and, when applicable, offering to pay compensation  to  the extent
required by 3(c)(l)(D) of the Federal Insecticide, Fungicide  and Rodenticide
                                      11

-------
Act  (FIFRA), as amended, 7 U.S.C. 136a(c)(1)(D). As discussed  in Chapter I,
applicants for registration under this Standard  should  contact the Agency for
specific instructions,  including updated  information  on data requirements and
companies whose data must be cited and to whom compensation must be offered.

1. Manufacturing-Use Products

   a.  Product Composition Standard

To be  covered under this Standard, manufacturing-use  products  must contain
phosalone as their sole active  ingredient.,   Such formulations  must contain
contain 94 percent active ingredient.  Each  formulation proposed for
registration must be fully described within  an appropriate certification of
limits.

   b.  Acute Toxicity Limits

The  Agency will consider registration of  manufacturing-use products containing
phosalone regardless of the toxicity category, provided that the labeling of
such products bears appropriate precautionary  statements.

   c.  Use Patterns

To be  covered under this Standard, manufacturing-use  only  products of phosalone
must be labeled to allow for formulation  only  into end-use insecticides/
miticides, which are intended for uses accepted  by the  United  States
Environmental Protection Agency.

2. End-Use Products

   a.  Product Composition Standard

Emulsifiable concentrate (EC) phosalone products containing 34.4 percent
(3 pounds per gallon) active ingredient or less  and wettable powder (WP)
formulations of 25 percent active ingredient or  less  will  be considered under
this standard.The appropriate certification  of limits must be  provided and the
application rates on a  per acre basis must remain the same or  be less.

   b. Acute Toxicity Limit

The Agency will consider for registration end-use products of  any toxicity
category.   This acceptance, however, is predicated upon label  incorporations of
appropriate hazard warnings, as well as precautionary and  use  restrictions
as required.

-------
   c. Use Pattern

To be considered under this standard, end-use products must  bear directions for
use as an insecticide/miticide, which are  intended  for outdoor commercial,
ground and aerial applications  (food or nonfood  uses).  The  use pattern of  this
insecticide/miticide may be expanded to include  outdoor domestic, ground
application  (food or nonfood uses), if the product  is in  child-resistant
packaging as described in 40 CFR 162.16.  Sites  of  application include  apples,
apricots, artichokes, cherries, grapefruit, grapes,  lemons,  nectarines, nuts,
oranges, peaches, pears, potatoes, prunes, arborvitae, and roses.

F. Required  Labeling

All manufacturing-use and end-use phosalone products must bear
appropriate  labeling as specified in 40 CFR 162.10.  The  guidance package
which accompanies this standard contains specific information  regarding label
requirements.

The  following  antidote information should  also appear on  all labels:

     "Causes  cholinesterase inhibition.  Atropine is antidotal.   2-PAM is also
     antidotal  and may be administered in conjunction with atropine.   Warning
     symptoms include weakness, headache, tightness  in the chest,  blurred
     vision,  nonreactive pinpoint pupils, salivation, sweating,  nausea,
     vomiting,  diarrhea, and abdominal cramps."

The  registrant may  submit an alternative antidote statement  for Agency
consideration.

Additional label restriction statements, grouped by manufacturing-use and end-
use  products,  are as follows:

1. Manufacturing-Use Products

All  manufacturing-use product labels must  bear the  following
statement:

     "For Formulation into End-Use Insecticide/Miticide Products Intended
     Only for Uses Accepted by the United States  Environmental  Protection
    Agency."
                                       13

-------
2. End-use Products

 a. Human Hazard Precautionary Statements

      1). All EC products must require the  use of goggles  in their warning
statements, because of the high acute eye irritation  hazard.  (Please refer to
Chapter VI on toxicology for a discussion.)

      2). The Agency is currently developing Guidelines  for reentry
intervals.  In addition the Agency  is currently  reviewing  the 24 hour reentry
interval, which was established in  40 CFR 170.   (Please  refer to Chapter V for
a detailed discussion.)  Until the  Guidelines and reentry  interval review are
complete, the Agency will require a 24 hour reentry interval.   Therefore, the
following statement must appear on  the label:

    "Reentry into treated fields is prohibited within 24 hours of
    application."

   b. Environmental Hazard Statements

Sufficient information is available to consider  phosalone  as being of low to
moderate toxicity to pollinators.   This  toxicity may  be  mitigated, if phosalone
is applied when the pollinators are not  foraging.   Therefore,  the following
statement must appear on all labels:

    "This product is toxic to bees  exposed  to direct  treatment or residues
    on blooming crops or weeds.  Do not  apply this  product if bees are
    visiting the treatment area."

    c. Additional Labeling

These statements are required in addition to those  standard precautionary
statements outlined by the guidance package.

       1). Because the Agency lacks supporting acute  human health effects
and environmental fate data, the following  statement  must  appear on the label.

    "This product is not for use in greenhouses."

       2). Because phosalone meets  the criteria  established in the child-
resistant packing regulations (40 CFR 162.16), all  products must be packaged
in such containers,  unless the following restriction  appears on the label:

    "For agricultural or commercial  use  only."
                                      H

-------
       3). There are data concerning the accumulation of phosalone  in
rotational crops, which indicate that phosalone and/or  its metabolites  are
taken up by radishes, beans, potatoes, and wheat under  greenhouse conditions
(Ambrosi et al., 1977, MRID 000006664).  Therefore,  the Agency  has  determined
that a crop rotation restriction must appear on the  label as  follows:

    "Do not use in crop rotation programs."

As an alternative to this label restriction, the registrant may choose  to
pursue any one of the following three options:

           a). Supply environmental fate data supporting a rotation interval
               which does not result in a pesticide  residue in  the  rotated
               crops; or

           b). Obtain a tolerance  for the nontarget  crop  (46  FR 3018);  or

           c). Obtain an exemption from a tolerance  for the nontarget crop.

In the interim, however, the label amendment described  previously will  be
required.

       4). Because of the potential toxicity to animals shown by the animal
metabolism data and residue information in Chapter VII, the following must
appear on the label:

    "Do not allow livestock to graze cover crops in  orchards  or nut groves
    treated with phosalone.  Do not feed cover crops treated  with phosalone
    to livestock."

G. Tolerance Reassessment

A listing of the tolerances for residues of phosalone in or on  raw  agricultural
commodities as stated in 40 CFR 180.263 and 21 CFR 193.340 is found in  Chapter
VII.Data summarized in this standard support these tolerances.

A report by the Food and Drug Administration shows that under the FDA
Regulatory Enforcement Program during the Fiscal Years  1977 thru 1980
approximately 1,480 agricultural crops were sampled  and analyzed.   About 86  of
these samples showed the presence  of small amounts of phosalone. None  of the
reported residues exceeded the residue tolerance levels established for
                                       15

-------
phosalone for these crops.  A summary of EPA estimated daily intakes of
phosalone based on these data in terms of mgAg  of  body  weight/day is reported
as follows:

              FY 1973     FY 1974     FY 1975     FY 1976

phosalone     0.000002    0.00002     0.00004     0.000001

A list of the CODEX Tolerances is also found in  Chapter  VII.  The CODEX
tolerance for pecans and chestnuts  (nuts) is 0.1 ppm, while  the U.S. tolerance
for all nuts  (including pecans and  chestnuts)  is 0.05 ppm.   Both tolerances are
based on the sensitivity of the method used.   In accordance  with Agency policy
of cooperation with FAO/WHO and the Codex Alimentarius Commission, and to
eliminate possible barriers to international trade,  the  Administrator will
initiate the change of 0.05 ppm to  0.1 ppm  for pecans and  chestnuts (nuts)
under the authority of the Federal  Food, Drug  and Cosmetic Act, Section 408 (e)
and 40 CFR  180.32.  Since there would be an insignificant  change in the present
Theoretical Maximum Residue Concentration (TMRC), this would make the U.S.
tolerance consistent with the CODEX tolerance.   The TMRC is  based on
established tolerances for phosalone residues  in or on raw agricultural crops.
The U.S. registered uses  for all other crops indicate it would not be advisable
to change their tolerances.

In calculating the TMRC the Agency  assumes  that  the chemical is applied to all
commodities on which its  use is authorized, that each commodity contains the
maximum level allowed  in  the tolerance, and that average 60  kilogram adult
eating patterns result in 100 percent of the phosalone-treated food in the
adult diet  of 1.5 kilogram per day.

Based on the published tolerances for phosalone  in  all crops for which it is
registered, the theoretical maximum residue concentration  (TKRC) is 1.0107
milligram per day for  a 1.5 kilogram diet for  13.5  percent of the maximum
permissible intake  (MPI).  The TMPC for all eleven  registered nut crops is
0.00022 milligram per day.  If the  tolerance is  increased  from 0.05 to 0.10
ppm, the nut 1MRC will be doubled to 0.00044 milligram per day, and the new
total 1MRC  will be  1.0109 milligram per day.   Increasing the 1MRC from 1.0107
to 1.0109 will result  in  virtually  no change in  the percentage ADI.  The
increase is approximately 0.02 percent of the  ADI.   The  revised TMRC (1.0109
milligram per day)  is  0.0168 milligram of phosalone per  kilogram body weight
per day for a 60 kilogram person.   Therefore,  there are  no toxicological
reasons for objecting  to  the revision of 0.05  ppm tolerance  in nuts to 0.1 ppm.

To calculate  the Acceptable Daily Intake  (ADI) for  the purpose of assessing the
toxicological significance of revising tolerances,  a no-observed-effect-level
(NOEL) of 25 ppn  is taken from the  two-year rat  feeding  study (Woodard et al.,
1967, MRID  000006202). This is equivalent to a 1.25 milligram per kilogram
per day NOEL.  Using a safety factor of ten (for extrapolation from a chronic
study in rats to man with respect to cholinesterase inhibition), the acceptable
                                      16

-------
daily intake  (ADI) is 0.125 milligram per kilogram per day  (determined  by
dividing the NOEL in milligram per kilogram by ten).  The MPI  is determined by
multiplying the ADI by 60 kilogram (assumed average body weight for  humans),
and is 7.5 milligram per person per day.

The tolerance for nuts was the only one for which a change was accepted.  All
established tolerances are considered adequate to protect public health.
                                      17

-------
                               TABLE  1
Summary of acute oral  LDrn  values  (ing/kg  body weight)  for
manufacturing-use phosalbne
Animal
Rats
Sex

Males
Females

Male and
Female
^50
                           90  (68-119)-

                          120  (105-135)
Reference

Fournel et al . ,
1968, MRID 000006716

Pasquet et al .
1976, MRID 005007746
             Females
            135
                   Dubost et al . ,  1963 ,
                   MRID 000006643
Mice
Unspecified 130
            190
                   Rivett and Davies, 1966,
                   MRID 000006697
             Unspecified 180
                         435-7
                               Dubost et al . , 1963 ,
                               MRID OOOOOC643
Guinea Pig   Unspecified 150
                               Dubost ct al . , 1963 ,
                               MRID 000006643
I/ 95% confidence intervals are given  in parentheses.

_2/ Phosalono was adninistered in an oil solution.  All other
   LDc- 's were determined with phosalone in aqueous
   suspens ion.
                                 -55a-

-------
                                               TABLE 2
Summary of acute oral L
of Phosalone
                                         values (mg/kg) for formulations
O
0)
 I
              Animal
              Rats
              Mice
             Sex

             Male and
             Female

             Males
                           Halves
                           Females
                           Male
              Females
              Unspecified
Formulation
    WP
                                           WP
                              EC
                              EC
                              EC
    EC
    EC
^50

 480
                     600
                     274
                 (195-385)-7

                     261
                 (169-403)-7
 488


>480
Reference

US EPA, 1973,
MRID GS0027005

US EPA, 1976,
MRID GS0027003

Scott and Deliles,
1965, MRID 00006688
                                                            190-'
US EPA, 1973,
MIUD GS0027006

US CPA, 1972,
MRID GS0027004

Rivett and Duvies
1966, KRID 00006697
              I/ 95% confidence limits

              2:/ Test material was 13 and 14 months old.

              3/ Test material was relatively fresh.

-------
CHAPTER III:  SUMMARY OF DATA REQUIREMENTS AND DATA GAPS
    A.  Introduction
    B.  Table A - Generic Data  Requirements
    C.  Table B - Product Specific  Manufacturing-Use Products Data Requirements
    D.  Table C - Product Specific  End-Use Product Data Requirements

A. Introduction

Applicants for registration of  manufacturing-use  and end-use
phosalone products must  cite or submit  the information identified as required
in the tables in this  chapter.   The tables applicable to end-use products
indicate whether the product to be  tested  is  the  technical grade or
formulation.  Data generated on one formulation may be used to satisfy the data
requirement for a substantially similar formulation.   Information on which
product specific data  requirements  are  already met is available in the guidance
package.

Before each requirement  is listed the section of  the Proposed Guidelines which
describes the type of  data and  when the data  are  required to be submitted
[43 FR, 29696 of July  10, 1978; and 43  FR, 37336  of August 22, 1978; 45 FR,
72948 of November 3, 1980]. Justification  for the test requirement is
provided in the Guidelines. A discussion of why data additional to those
already submitted are  necessary, or why data  normally required are not
necessary for this chemical, is explained  in  footnotes to the tables.  The
data requirements specified are the minimum that  will be required.  Areas where
additional data may be required as  the  result of  tiered testing are indicated.
                                       19

-------
                                                      Table A:  Phosalone
                                 Generic Data Requirements:   Environmental Fate  (See Chapter V)
Guidelines
Citation


163.62-7(b)


163.62-7(c)


163.62-8(b)


163.62-8(c)


163.62-8(f )






163.62-8(g)
Name of Test



Hydrolysis


Photodegradation


Aerobic Soil
Metabolism

Anaerobic Soil
Metabolism

Microbial Metabolism:
(2) Effects of
Microbes on
Pesticides
(3) Effects of
Pesticides on
Microbes
Activated Sludge
Composition



Tech. or
Radiolabeled
Analytical Gr.
Tech. or
Radiolabeled
Analytical Gr.
Tech. or
Radiolabeled
Analytical Gr.
Tech. or
Radiolabeled
Analytical Gr.

Tech.


Tech.


Tech.
Does EPA Have Data Bibliographic Must Additional Data
to Partially or Citation be Submitted Under
Totally Satisfy FIFRA 3(c) (2) (B)?
this Requirement? If so, due when?
partially-/ Laurent et al., 000006067 yes/12 mo.


yes Ambrosi et al., 000006409 no
Ambrosi et al., 000006666
Laurent et al., 000006665
yes -/ no


no - yes/14 mo.



reserved-/ Ambrosi et al., 000006666
Dasmoras et al., 000006770

reserved-/ Ambrosi et al.r 00006667


reserved—
               Metabolism
All data requirements are current as of August, 1981.  Refer  to the guidance package  for updated requirements.

-------
I/ This data requirement has only partially been fulfilled.   The guidelines  require  that studies  be conducted
   using two temperatures and two concentrations.  Therefore, an additional  hydrolysis  study using a
   concentration lower than 1.5 ppm and at a temperature other  than  20   is needed  to assess  the fate of
   phosalone in the water.
2/ ftmbrosi et al., 000006409
   Ambrosi et al., 000006664
   Ambrosi et al., 000006666
ftmbrosi et al.,  005008305
Ambrosi et al.,  005009356
Desmoras et al., 000006770
_3_/ The requirement for the submission of  these data  is currently being reserved, pending  the  review and
   modification of the testing protocols.

-------
                                                       Table A:  Phosalone
                                 Generic Data Requirements:  Environmental Fate  (See Chapter V)
Guidelines
Citation
163.62-9
163.62-9(0)
Name of Test
Leaching
Volatility
Composition
Tech. or
Radiolabeled
Analytical Gr.
Tech. Grade
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
partially-/ -/
reserved—'
Bibliographic
Citation
Ambrosi et al., 000006663
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?*
yes/12 mo.
163. 62-9 (d)

163.62-10(b)
163.62-10(f)
Adsorpt ion/Desorption

Terrestrial Field
Dissipation:

(1) Field & Vegetable
    Crops
                (2) Tree Fruit & Nut
                   Crop Uses
Combination and
Tank Mix Field
Dissipation
Tech. or
Radiolabeled
Analytical Gr.
A representive
formulated
product

A representive
formulated
product
                                                              no
                                              no
yes/12 mo.
                                                                                                               yes/26  mo.
yes/26 mo.
All data requirements are current  as of August,  1981.   Refer  to  the guidance package  for updated  requirements.

I/ For terrestial noncrop users, orchard  crop  uses,  the mobility of the  test substance  and  its  degradates
in soil shall be assessed either by soil  thin-layer  chroma tography , soil column, or batch equilibrium
(absorption/desorption) procedures.

2/ The rapid leaching study of parent material (phosalone)  is valid, but the aged  portion of  the  study is
   incomplete.  (Please refer to Chapter  V for a detailed discussion).   Therefore, data are still required.

_3_/ The vapor pressure is not known.  When this data  gap has been filled, an assessment  can  be made concerning the
   need for a volitilization study.
4/ Not applicable  in single active  ingredient  standards.

-------
                                                       Table A:  Phosalone
                                  Generic Data Requirements:  Environmental Fate (See Chapter V)
Guidelines
Citation
163.62-10(g)
163.62-ll(b)
163.62-ll(d)

Name of Test
Long Term Field
Dissipation Study
Accumulation in
Rotational Crops
Fish Accumulation

Composition
-
Radiolabeled
Analytical Gr.
Followed by
Formulation
Tech. or
Radiolabeled
Analytical Gr.
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
reserved—
partially-/
partially-/

Bibliographic
Citation
-
Ambrosi et al., 000006664
Barrows, M.E., 000006109

                                                                                                            Must Additional Data
                                                                                                            be Submitted Under
                                                                                                            FIFRA 3(c)(2)(B)?
                                                                                                            If so, due when?
                                                                                                                   yes/26 mo.
                                                                                                                   yes/26 mo.
 163.62-12
Reentry
 163.62-13
Disposal & Storage
A Representative
Formulated
Product
Tech. and All
Formulated Products
partially-/
reserved—
Khaak et al., 005003635
Leffingwell et al., 005007744
Leffingwell et al., 005007745
Popendorf et al., 005005243
Winterlin et al., 005001343
All  data requirements are current as of August, 1981.  Refer to the guidance package for updated requirements.

I/ The  requirement for the submission of these data is currently being reserved pending the receipt and evaluation of
   data on terrestial field dissipation.  Consequently the absence of acceptable data does not constitute a data
   gap.

_2/ Additional data from field studies are needed to identify residues accumulated by radishes, beans,  potatoes,  and
~  wheat planted as rotational crops in phosalone-treated fields.  In addition, all studies specified  in Section
   163.62-ll(b)  are needed for all other crops that may be planted in rotation with phosalone-treated  crops.  However,
   this  crop rotation restriction may be removed as discussed in Chapter V.

3/ An additional study, using a flow-through system and identifying radio-labeled residues, is needed  to satisfy data
~  requirements  in Section 163.62-11(d).

4/ Until the Guidelines and the reentry interval review is complete, the Agency intends to maintain the 24 hour
~  reentry interval as an interim measure.  If the registrant wishes to appeal, interval data may be submitted to the
   Agency to support a change.  Please see Chapter V for a discussion.
5/ Guidelines  for  this  Section have not been completed, consequently the absence of acceptable data does not constitute a data gap.

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                                                  Table A:   Phosalone
                                Generic Data Requirements: Toxicology  (See Chapter VI)
Guidelines
Citation


163.81-1



163.81-2

163.81-3

163.81-4

163.81-5

163.81-6

163.81-7

163.82-1




163.82-2

Name of Test



Acute Oral Toxicity



Acute Dermal Toxicity

Acute Inhalation
Toxicity
Primary Eye
Irritation
Primary Dermal
Irritation
Dermal Sensitization

Acute Delayed
Neurotoxicity
Subchronic Oral
Toxicity



Subchronic 21-Day
Dermal
Composition Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
Each Product yes
or Substantially
Similar Product

Ea. Prod, or yes
Substan. Sim. Prod.
Ea. Prod, or no
Substan. Sim. Prod.
Ea. Prod, or no—'
Substan. Sim. Prod.
Ea. Prod, or no
Substan. Sim. Prod.
Ea. Prod, or no
Substan. Sim. Prod.
Tech. Grade of A.I. no-/

Tech. Grade of A.I. yes




Tech. Grade of A.I. no

Bibliographic Must Additional Data
Citation be


Dubost et al., 000006643
Fournel et al., 000006716
Pasquet et al . , 005007746
Rivett and Davies, 000006697
Dubost et al., 000006643
Pasquet, 005007746
_

-

_

-

-

Donoso et al., 000006203
Fournel et al., 000006684
Jones et al., 000006205
Noel et al., 000006111
Woodward et al. 000006202
-

Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
no



no

yes/6 mo.

yes/6 mo.

yes/6 mo.

yes/6 mo.

yes/12 mo.

no




yes/12 mo.

All data requirements are current as of August, 1981.  Refer  to  the guidance package  for  updated  requirements.

V There are data available for the EC formulation.  The  registrant may  use this  study (Horn et al.,  1965,  MRID 000006690)
   to fulfill this requirement.  However, this places  the manufacturing-use product  in Toxicity Category I.  In this event
   the Agency would require changes in the label, including a statement  specifying the use of protective clothing.

2/ Data are required, because phosalone caused cholinesterase depression.

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                                                       Table A:  Phosalone
                                          Generic Data Requirements:  Toxicology  (See Chapter VI)
 Guidelines     Name of Test
 Citation
 163.84-2
 through—4
 163.85-1
Mutagenicity
Metabolism and
Pharmacodynamics
                        Composition
                       Does EPA Have Data
                       to Partially or
                       Totally Satisfy
                       this Requirement?
Bibliographic
Citation
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
163.82-5

163.83-1

163.83-2

163.83-3

163.83-4




Subchronic
Neurotoxicity
Chronic Feeding
Tbxicity
Oncogenicity

Teratogenicity

Reproduction




Tech. Grade of A.I. yes

lech. Grade of A.I. yes

Tech. Grade of A.I. yes

Tech. Grade of A.I. yes

Tech. Grade of A.I. yes
/



Woodward et al., 000006695

Vfoodward et al. 000006202

Rhone-Poulenc, Inc. GS0027021
Woodard et al. , 000006202
Khera et al., 005008254
Pasquet and Buisson, 000006110
Benazet and Cartier, GS0027020
Collins and Ings, 00006977
Desmoras et al., 000006715
Jones et al., 00006204
Khera et al., 05008254
no

no

no

no

no




Tech. Grade of A.I.
                              yes
Analytically
Pure Radioactive
Grade
                                                                      yes
Pasquet and Buisson, 00006110

Benazet and Cartier GS0027020      no
Collins & Ings, 000006977
Desmoras et al., 000006715
Goldenthal et al., GS0027019
Jones et al., 000006204
Khera et al., 005008254
Pasquet and Buisson, 000006110
Rhone-Poulenc, Inc., GS0027021
Wbodard et al.  000006202

Collins and Ings, 000006977        no
Craine, 000006972, 000006973,
  and 000006975
Desmoras et al.  000006715
Fournel et al., 000006716
Pasquet et al., 005007746
All data  requirements are current as of August, 1981.  Refer to the guidance package for updated requirement

-------
Guidelines
Citation
                                                        Table A:   Phosalone
                                    Generic Data Requirements:  Residue Chemistry (See Chapter VII)
Name of Test
Composition
                                               Does EPA Have Data
                                               to Partially or
                                               Totally Satisfy
                                               this Requirement?
Bibliographic
Citation
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If So, due when?
                Metabolism in Plants

                Metabolism in Animals


                Analytical Methods

                Residue Data:
                Crops

                Residue Data:
                Processed  Crops

                Residue Data:
                Milk & Meat

                Storage Stability
                                  V
                                  !/

                                  V

                                  V

                                  V

                                  V

                                  I/
                        yes

                        yes


                        yes

                        yes


                        yes


                        yes


                        yes
      2/                                 no

Desnoras et al., 000006715               no
Craine, E.M., 000006974

      3/                                 no

      4/                                 no


      5/                                 no
      6/
Desmoras et al., 000006968               no
Klisenko and Pis'mennaya, 005014548
Laurent et al., 000006698
Rhodia, Inc., 000006113
All data requirements are current  as  of  August,  1981.   Refer to the guidance  package for updated requirements.

I/ Residue of Active Ingredient  and its  Metabolites Which may be of Toxicological Concern.

y Ainbrosi et al.                  000006125
   Desnoras et al.                 000006791
   Desnoras et al.                 000006386
   FAO Working Party               005013895
   Kbvaleva, E.S.                  005014688
   Nalbanyan, R.A.                 005016356
   Societe des Usines              000006675
   Chimiques Rhone - Poulenc
   Winterlin et al.                005009309

-------
3_/ Desmoras, J.                   005016979
   Guardigli, A.                  000006383
   Guardigli, A.                  000006703
   Guardigli, A.                  000006129
   Guardigli, A.                  000006762
   Guardigli, A.                  000006105
   Guardigli, A.                  GS0027010
   Guardigli and Melkesian        000006083
   Guardigli et al.               005008180
   Guardigli et al.               000006678
   Laurent et al.                 000006700
   Societe des Usines             000006701
   Chimiques Rhone-Poulenc

4/ Almond nutmeats and almond hulls

   Guardigli, A.                   000006358

   Brazil nuts, bush nuts, butternuts, cashews, chestnuts, filberts, hazelnuts, hickery nuts, macadamia nuts,
   pecans and walnuts  (except almonds)

   Residue data were submitted for pecans and walnuts under the provision in CFR 40, 180.34 f. i.e.  "It may be
   possible to make a  reliable estimate of negligible residues of pesticide chemicals to be expected on each
   commodity in a designated grouping on the basis of data on a representative number of commodities listed in
   the following designated groups."  Accordingly the submitted data for pecans and walnuts are to be extended to
   the other nutcrops mentioned above.

   Pecans

   Guardigli, et al.              000006511

   Walnuts

   Guardigli, et al.              000006511

   Apples

   Desmoras et al.                000006707
   Guardigli, A.                  000006388
   Guardigli, A.                  000006783
   Guardigli, A.                  000006711
   Guardigli, A.                  000006084
   Rhodia, Inc.                   000006712

-------
        Pears
ro
CO
Guardigli, A.,                  000006714
Guardigli, A.                   000006392

Grapes

Desiroras et  al.                 000006707
Guardigli, A.                   000006390
Guardigli, A.                   000006713
Guardigli, et al.               000006480
Laurent et al.                  000006708

Citrus Fruit

Guardigli, A.                   GS0027014
Guardigli, A.                   GS0027015
Guardigli, A.                   GS0027016

Artichokes

Henckler, P.                    000006964
Societe des  Usines Chiniques    GS0027009
Khone-Poulenc

Potatoes

Guardigli, A.                   000006395
Guardigli, et al.               000006576

Apricots

Henckler et  al.                 000006483
US EPA                          GS0027006

Cherries

Guardigli, A.                   000006389
Henckler et  al.                 000006484
US EPA                          GS0027006

-------
        Nectarines
ro
to
   Henckler et al.
   IB EPA

   Peaches

   Guardigli, A.
   Henckler et al.
   Rhodia, Inc.,
     Chipinan Division

   Plums_( fresh prunes)

   Rhodia, Inc., Chipman
   Division
   Henckler et al.
   Guardigli, A.

V Dried. Raisins

   Guardigli, et al.

   Dried^jSrape Pomace

   Dennis, S.

   Dried _Apple Pomace

   Guardigli, A.
   Rhodia, Inc.

   Dried Citeu£[_Pulp

   Guardiglia, A.

         Prunes
        Guardigli, A.
        Henckler, et al.
                                       000006485
                                       GS0027006
                                       000006391
                                       000006486
                                       GS0027025
                                       GS0027025

                                       000006487
                                       000006769
                                       000006480
                                       000006069
                                       000006068
                                       000006357
                                       GS0027016
                                   000006769
                                   000006487

-------
   Dried tea
   Desmoras, et al.                000006209
   Rhodia, Inc.                    000006210
   Crouch, R.V.                    000006735

6/ Meat, milk, poultry and eggs.

   Collins et al.                  000006978
   Craine, E.M.                    000006972
   Craine, E.M.                    000006973
   Craine, E.M.                    000006974
   Craine, E.M.                    000006975
   Guardigli, A.                   000006971
   Posner, S.                      000006761
   Posner, S.                      000006792
   Rhodia, Inc.                    000006120
   Rhodia, Inc.                    000006123
   Rhodia, Inc.                    000006717
   Tbtman et al.                   000006073
   Tbtman et al.                   000006071

-------
Guidelines
Citation
                                                  Table A:  Phosalone
                               Generic Data Requirements:   Ecological Effects (See Chapter VIII)
Name of Test
Composition
                                              Does EPA Have Data
                                              to Partially or
                                              Totally Satisfy
                                              this Requirement?
                Bibliographic
                Citation
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
 163.71-1


 163.71-2

 163.71-3

 163.71-4

 163.71-5


 163.72-1

 163.72-2


 163.72-3


 163.72-4



 163.72-5


 163.72-6
Avian Single-Dose Oral
^50

Avian Dietary !£,-„

Mammalian Acute Toxicity

Avian Reproduction

Simulated and Actual Field
Testing for Mammals & Birds

Fish Acute LC5Q

Acute Toxicity to Aquatic
Invertebrates

Acute Toxicity to Estuarine
& Marine Organisms

Embryolarvae & Life-
cycle Studies of Fish &
Aquatic Invertebrates

Aquatic Organism Toxicity
& Residue Studies

Simulated or Actual
Field Testing for
Aquatic Organisms
   Tech.
   Tech.
   Tech.

   Tech.
                        no
                        no
                  reserved—'

                  reserved—'

                  reserved—'
no

no
                  reserved—'
                  reserved-
                  reserved—'
                  reserved—
     yes/11 mo.


     yes/11 mo.

     I/

     I/

     V


     yes/11 mo.

     yes/11 mo.


     V


     V



     V


     V
These data  requirements are current as of August, 1981.  Refer to the guidance package for updated requirements.

I/ The requirement for the submission of the data is currently reserved, pending the results of the outstanding
~  data.

-------
                              Generic Data Requirement!:  'Ecologica?eEffects (See Chapter VIII)
Guidelines
Citation
163.122-1
163.122-1
163.122-2
163.122-2
Name of Test
Seed Germination
Vegetative Vigor
Aquatic Macrophytes
Algae
Composition
Technical
Technical
Technical
Technical
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
no
partially^
no
no
Bibliographic
Citation
.
y
-
-
Must Additional Data
be Submitted Under
FIFRA 3(C)(2)(B)?
If so, due when?
yes/26 mo.
yes/26 mo.
yes/26 mo.
yes/26 mo.
All data requirements are  current  as  of August,  1981.   Refer to the guidance  package  for updated  requirements.

_!/ The data requirement has been partially filled by the following studies  in aggregate:
   Ciarletta et  al.
   Delay, D.L.
   Delay, D.L.
   Delay, D.L.
   Eckenrode et  al.
   Ishitani et al.
   Knobel, H. and Rock, G.
   Knobel, H. and Rock, G.
   Lillie, D.T.
   Lillie, D.T.  and Carman,
   Lillie, D.T.  and Carman, G.
   Preiser, F.A. and Taschenberg,  E.F.
   Rhod ia, Incorporated
   Smyth et al.
   Smyth, E.P. and Hoyt, S.
   Smyth, E.P. and Jones, S.C.
   Spencer, W.T. and Hofmaster, R.N.
   Szabo, J. and Walls, A.
   Szabo, J. and Sleesman, J.P.
                   G.
   Wang,
   Wang,
   Wang,
   Wang, D.
   Wang, D.
D.
D.
D.
000014256
000006528
000006534
000006569
005015711
005006342
000006938
000006939
000006430
000006747
000006748
000006479
000006733
000006243
000006639
000006283
000006738
000006592
000006593
000006114
000006115
000006289
000006477
000006145
To complete the vegetative vigor data  requirement,  data are needed on the effects of phosalone on raonocot plants.

-------
Guidelines
Citation
163.61-3
163.61-4
                                                        Table B;   Phosalone
                  Product Specific Manufacturing-Use Products Data Requirements:   Product Chemistry  (See Chapter IV)
Name of Test
Product Identity
& Disclosure of
Ingredients

Description of
Manufacturing
Process
Composition
Each Product
Each Product
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?

      yes
                                                             yes
Bibliographic
Citation
Must Additional Data"
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?

    yes!/
                                          yes—/
163.61-5
163.61-6
163.61-7
Discussion on
Formation of
Unintentional
Ingredients

Declaration &
Certification of
Ingredients Limits

Product Analytical
Methods & Data
Each Product
Each Product
Each Product
                                                             yes
                                                             yes
                                                             yes
                                                                                  2/
                                                                                                no
These data  requirements  are  current as  of August,  1981.   Refer to the  guidance package  for updated  requirements.

I/ This requirement must be  fulfilled by each applicant.   Data from other applicants may not be  cited.  Therefore,
~  even if  the  requirement has  been partially or completely fulfilled  for some products, no references are given.
   This requirement must be  filled  at the time of  registration.   However,  this requirement has been fulfilled  for
   current  registrations.  Please refer to Chapter IV for a discussion of the data.
 2/ Brun et al., 005005128
    Guardigli, A.,  000006640
    Guardigli, A.,  000006170
                   Henckler, R., 000006107
                   Laurent, M., 000006645
                   Maharova et  al., 0050011351
                                Societe des Usines Chemiques Rhone -
                                Societe des Usines Chemiques Rhone -
                                Societe des Usines Chemiques Rhone -
                                                    Poulenc, GS0027009
                                                    Poulenc, 000006398
                                                    Poulenc, 000006943

-------
                                                        Table B:   Phosalone
                  Product Specific Manufacturing-Use Products  Data Requirements:  Product Chemistry  (See Chapter IV)
Guidelines
Citation
163
,61-8(c)
Name of Test
(1)
Color
Composition
Does EPA Have Data Bibliographic
to Partially or Citation
Totally Satisfy
this Requirement?
Technical Grade of
yes —
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
yesi/
Active Ingredient
163
163
163
163
163

163
163
163
163
163
.61-8(c)
.61-8(c)
.61-8 (c)
.61-8(c)
.61-8(c)

(2)
(3)
(4)
(5)
(6)

.61-8(c)(7)
.61-8(c)
(8)
.61-8(c)(9)
.61-8(c)
.61-8(c)
(10)
(ID
Cdor
Melting Point
Solubility
Stability
Cctanol/Water
Partition Coefficient
Physical State
Specific Gravity
Boiling Point
Vapor Pressure
PH
Tech.
Tech.
Tech.
Tech.
Tech.

Tech.
Tech.
Tech.
Tech.
Tech.
Grade
Grade
Grade
Grade
Grade

Grade
Grade
Grade
Grade
Grade
of
of
of
of
of

of
of
of
of
of
A.
A.
A.
A.
A.

A.
A.
A.
A.
A.
I.
I.
I.
I.
I.

I.
I.
I.
I.
I.
yes —
yes —
partially-/ —
yes —
yes

yes ~~~~
no —
4/ —
no —
v —
yes—
yesi/
ves^/
yesi/
yes-

yes—
yes—'
no
yes^/
no
These data requirements are current as of August,  1981.  Refer  to the guidance package  for  updated requirements.

I/ These requirements must be fulfilled  by each  applicant.   Data from other applicants  may  not  be cited.  Therefore,
   even if the requirements have been partially  or completely fulfilled for some products,  no references  are given.
   These requirements must be filled at  the  time of registration.  However, this requirement has been fulfilled  for
   current registrations.  Please refer  to Chapter IV for a  discussion.

2/ This requirement must be fulfilled by each  applicant.  Data  from other applicants may not be cited.  Therefore, even
~~ if the requirement has been partially or  completely fulfilled for some products, no  references are given. This
   requirement must be filled at the time of registration or reregistration.

3/ Since phosalone is practically insoluble  in water,  the solubility for  other solvents i.e. benzene, dioxane, methylene
~~ chloride, methanol, ethanol, choroform, xylene  etc. in terms of g/lOOml  of solvent at 20 C or in  ppm should be
   reported to fulfill this requirement  for  current registrations.

-------
     4/ This is not needed, because phosalone is a solid.

     5/ Phosalone is practically insoluble in water (1.7 ppm at 20°C); therefore, no pH data are required.
OJ
in

-------
                                                            Table B:  Phosalone
                     Product Specific Manufacturing-Use Product Data Requirements:  Product Chemistry  (See Chapter IV)
     Guidelines
     Citation
Name of Test
Composition
OJ
en
     163.61-8(c)(12)  Storage Stability


     163.61-8(c)(13)  Flammability


     163.61-8(c)(14)  Oxidizing/Reducing
                      Action

     163.61-8(c)(15)  Explosiveness


     163.61-8(c)(16)  Miscibility
     163.61-8(c)(17)  Viscosity
                      Coefficient

     163.61-8(c)(18)  Corrosiveness
                                          Does EPA Have Data
                                          to Partially or
                                          Totally Satisfy
                                          this Requirement?
Bibliographic   Must Additional Data
Citation        be Submitted Under
                FIFRA 3(c)(2)(B)?
                If so, due when?
                        Each Manufacturing-    yes
                        Use Product

                        Each Manufacturing -   no
                        Use Product

                        Each Manufacturing-    yes
                        Use Product

                        Each Manufacturing-    no
                        Use Product

                        Each Manufacturing-    no
                        Use Product

                        Each Manufacturing-    no
                        Use Product

                        Each Manufacturing-    no
                        Use Product
                                                             yes—'
                                                             yes2/
                                                             yes2/
                                                             yes!/
                                                             yes—'
                                                             yes2/
     These data requirements are current as of August, 1981.  Refer to the guidance package for updated  requirements.

     I/ This requirement must be fulfilled by each applicant.  Data from other applicants may not be  cited.   Therefore,  even if
     ~  the requirement has been partially or completely fulfilled for some products, no references are  given.
        This requirement must be filled at the time or registration.  However, this requirement has been fulfilled  for
        current registrations.  Please refer to Chapter IV for a discussion of the data.

     2/ This requirement must be fulfilled by each applicant.  Data from other applicants may not be  cited.   Therefore,
     ~  even if the requirement has been partially or completely fulfilled for some products, no references  are given.
        This requirement must be filled at the time or registration or reregistration.

-------
                                                        Table C:   Phosalone
                     Product  Specific End-Use Products Data Requirements:   Product Chemistry (See Chapter IV)
Guidelines
Citation
               Name of Test
Composition
163.61-3
163.61-4
                Product  Identity
                &  Disclosure  of
                Ingredients

                Description of
                Manufacturing
                Process
Each Product
Each Product
Does EPA Have Data
 to Partially or
 Totally Satisfy
 this Requirement?

      yes
                                                            no
                                                                            Bibliographic
                                                                             Citation
Must Additional Data
 be Submitted Under
 FIFRA 3(c)(2)(B)?
 If so, due when?

       yesi/
                                             yes!/
 163.61-5        Discussion on
                Formation of
                Unintent ional
                Ingredients

 163.61-6        Declaration &
                Certification of
                Ingredients Limits

 163.61-7        Product Analytical
                Methods & Data
                                    Each Product
                                    Each Product
                                    Each Product
                                                            yes
                                                            yes
                                                            yes
                                             3/
                                                               yes*/
                                                                                                   no
These data requirements are current as of August,  1981.   Refer to the guidance  package  for updated  requirements.

I/ This  requirement must be fulfilled by each applicant.   Data from other applicants  may not be  cited.   Therefore,  even
   if the  requirement has been partially or completely fulfilled for some products, no  references are given.   These
   requirement  must be filled at the time of registration.   However, this requirement  has been  fulfilled  for current
   registrations.   Please refer to Chapter IV for  a discussion of the data.

2/ This  requirement must be fulfilled by each applicant.   Data from other applicants  may not be  cited.   Therefore,  even
~  if the  requirement has been partially or completely fulfilled for some products, no  references are given.  This
   requirement must be filled at the time or registration or reregistration.
3/ Brun et al.,  05005128
   Guardigli, A.,  00006640
   Guardigli, A.,  00006170
   Henckler, P., 00006107
   Laurent, M. 00006645
                                              Makarova et al., 05011351
                                              Societe des Usines Chemiques Rhone-Poulenc, 00006398
                                              Societe des Usines Chemiques Rhone-Poulenc, GS0027009,
                                              Societe des Usines Chemiques Rhone-Poulenc, 00006943

-------
                                                               Table C:  Phosalone
                                    Product Specific End-Use Products Data Requirements: Product Chemistry (See Chapter IV)
GO
co
Guidelines
Citation
163.61-8(c)(l)
163.61-8(c)(2)
163.61-8(c)(7)
163.61-8(c)(8)
163.61-8(c)(ll)
163.61-8(c)(12)
163.61-8(c)(13)
163.61-8(c)(14)
163.61-8(c)(15)
163.61-8(c)(16)
163.61-8(c)(17)
163.61-8(c)(18)
Name of Test
Color
Odor
Physical State
Specific Gravity
pH
Storage Stability
Flammability
Oxidizing/Reducing
Action
Explos iveness
Miscibility
Viscosity Coefficient
Corros iveness
Composition
Each
Each
Each
Each
Each
Each
Each
Each
Each
Each
Each
Each
Product
Product
Product
Product
Product
Product
Product
Product
Product
Product
Product
Product
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
no
no
no
no
no
no
no
no
no
no
no
no
Bibliographic Must Additional Data
Citation be Submitted Under
FIFRA 3(c)(2)(B)?
If So, due when?
yesi/
yesi/
— yes—
yesi/
yes^-/
yes^
yes^
yesi/
yes—
yes^/
yes—
yes^/












           These data requirements are current as of August, 1981.  Refer to the guidance package for updated requirements.

           I/ This requirement must be fulfilled by each applicant.  Data from other applicants may not be cited.  Therefore, even if
              the requirements have been partially or completely fulfilled for some products, no references are given.
              This requirement must be filled at the time of registration or reregistration.

-------
                                    Table C:  Phosalone   (Emulsifiable Concentrate)
                      Product Specific End-Use Product. Data Requirements:  "toxicology  (See  Chapter VI)
Guidelines
Citation


163.81-1



163.81-2

163.81-3

163.81-4

163.81-5

163.81-6

Name of Test



Acute Oral Toxicity



Acute Dermal Toxicity

Acute Inhalation
Toxicity
Primary Eye
Irritation
Primary Dermal
Irritation
Dermal Sensitization

Composition



Each Product
or Substantially
Similar Product

Ea. Prod, or
Substan. Sim. Prod
Ea. Prod, or
Substan. Sim. Prod
Ea. Prod, or
Substan. Sim. Prod
Ea. Prod, or
Substan. Sim. Prod
Ea. Prod, or
Substan. Sim. Prod
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
yes



yes
•
yes
•
yes
•
no
•
no
•
Bibliographic Mi
Citation bt
F:
ii
Rivett and Davies, 000006697
Scott and Beliles, 000006688
US EPA, GS0027004
US EPA, GS0027006
Horn et al., 000006689

Beliles, 000006981

Horn et al., 000006690

-

_

                                                                                                         Must Additional  Data
                                                                                                         be Submitted Under
                                                                                                         FIFRA  3(c)(2)(B)?
                                                                                                         If so, due when?
                                                                                                                 no
                                                                                                                 no
                                                                                                                 no
                                                                                                                 no
                                                                                                                 yes/6 mo.


                                                                                                                 yes/6 mo.
All data requirements are  current  as of August,  1981.   Refer  to  the guidance package for updated requirements.

-------
                                              Table C:   Phosalone   (Wettable  Powder)
                        Product Specific End-Use Product Data Requirements:   Toxicology  (See  Chapter VI)
Guidelines Name of Test
Citation
163.81-1 Acute Oral Toxicity
163.81-2 Acute Dermal Toxicity
163.81-3 Acute Inhalation
Toxicity
163.81-4 Primary Eye
Irritation
<=> 163.81-5 Primary Dermal
Irritation
163.81-6 Dermal Sensitization
Composition Does EPA Have Data Bibliographic Must Additional Data
to Partially or Citation be Submitted Under
Totally Satisfy FIFRA 3(c) (2) (B)?
this Requirement? If so, due when?
Each Product yes US EPA, GS0027005 no
or Substantially US EPA, GS0027003
Similar Product
Ea. Prod, or yes^ Horn et al., 000006689 no
Substan. Sim. Prod.
Ea. Prod, or yes-^ Beliles, 000006981 no
Substan. Sim. Prod.
Ea. Prod, or no - yes/6 mo.
Substan. Sim. Prod.
Ea. Prod, or no - yes/6 no.
Substan. Sim. Prod.
Ea. Prod, or no - yes/6 mo.
Substan. Sim. Prod.
All data requirements are current as of August, 1981.  Refer to the guidance package  for  updated requirements.

I/ The data for the EC formulation will fulfill this data  requirement  for the WP formulation.

-------
CHAPTER IV: PRODUCT CHEMISTRY

    A. Chemistry Profile
    B. Data Gaps

A. Chemistry Profile

The data concerning product  chemistry,  which fulfill  or partially fulfill
Agency guideline requirements  are  discussed  below.  They are grouped by topic,
corresponding  to specific  sections in the  guidelines.

1. Chemical Identity

Phosalone  is the accepted  common name for  0,0-diethyl  S-[(6-chloro-2-
oxobenzoxazolin-3-yl-)methyl]  phosphorodithioate  as determined  by the American
National Standards Institute (1967).   Trade  names for phosalone include
Zolone®, Rubitox®, RP-11974  and NPH-1091.

The molecular  weight of phosalone  is  367.82.   The chemical  formula is
C12H15PS2N°4C1 (Sauli' M" 1975' MRID 005017962).

No additional  data are required with  regard  to phosalone's  chemical identity
for current manufacturing-use  and  end-use  product registrations.

2. Manufacturing Process

Rhodia, Inc.,  Agricultural Division,  Monmouth Junction,  New Jersey, is the
sole registrant for phosalone  in the  United  States.   It is  manufactured by
Rhone-Poulenc,  Inc. in Paris,  France.

Sauli (1975, MRID 005017962) describes a French patent in which phosalone is
synthesized in a single phase  condensation process of  an alkali salt or
an ammonium salt of 0,0-diethyldithiophosphoric acid,  formaldehyde and 6-chloro-
benzoxazolone  in the presence  of methane sulphonic acid.

A complete description of  the  manufacturing  process has been supplied to the
Agency.  Details of this process,  however, are considered by the Agency to be
trade secret information and will  not be provided within this standard.

No further information is  required for the current manufacturing-use product.
No data are available for  the  end-use products.

3. Formation Of Unintentional  Ingredients

Detailed information is available  concerning  unintentional  impurities which
may be present in technical  phosalone.   Like  the  manufacturing
process, this  information  is considered trade secret  and will not be provided
within this standard.


                                       41

-------
The data which have been submitted fulfill this data requirement  for  the
current manufacturing-use and end-use product registrations.

4. Percentage Of Active Ingredient in Pesticide Products

A confidential statement of formula by Rhodia, Inc. reveals  that  technical
phosalone contains 94 percent active ingredient.  The  remaining six
percent consists of manufacturing impurities.

Phosalone is sold as an EC containing 34.4 percent active  ingredient  (three
pounds active ingredient per gallon) and as a WP containing  25 percent active
ingredient.

The information concerning the remaining ingredients for the technical and
formulated products, as well as the nature of these formulations,  is  considered
trade secret and, hence, will not be described within  this standard.

No additional data are required for the current manufacturing-use and end-use
product registrations.

5. Product Analytical Methods and Data

Analytical methods for the identification and quantification of phosalone in
the technical material and formulated end-use products have  been  submitted.
Methods for the analysis of unintentional impurities have  also been submitted
and are considered to be adequate.

The methods consist of Gas-Liquid Chromatography with  electron capture
detection and various Thin Layer Chromatographic procedures  (Guardigli,  A.,
1968, MRID 000006170; Guardigli, A., 1969, MRID 000006640; Henckler,  P., 1973,
MRID 000006107; Societe des Usines Rhone-Poulenc, Inc., 1973,  GS0027009;
Societe des Usines Chimiques Rhone-Poulenc, 1966, MRID 000006398).

Infrared (IR) and Ultraviolet  (UV) spectra for phosalone have also been
submitted (Societe des Unines Chemiques Rhone-Poulenc, 19??,  MRID 000006943).
A colorimetric method including IR and UV spectrometry is  detailed in Laurent
(1964, MRID 000006645.)  An alternate method for phosalone identification
consists of a procedure combining thin-layer chromatography  and fluoresence
spectroscopy (Brun et al., 1973, MRID 005005128).  Another method for the
determination of phosalone entails the application of  iodometric  titration
(Makarova et al., 1972, MRID 005011351).

These various analytical methods have been reviewed by the Agency and have been
found to fulfill all data requirements with respect to analytical methodology
for current manufacturing-use and end-use product registrations.
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6. Physical and Chemical Properties

The data which are available concerning these properties  for manufacturing-use
phosalone are described below.  Unless otherwise  indicated  these data
requirements are considered fulfilled for the current manufacturing-use
products.  There are no data available to describe  the  formulated  products.

  a. Color

     The color is white  (Rhodia,  Inc., 19??, MRID 000006651).

  b. Cdor

     The odor is reminiscent of garlic  (Rhone-Poulenc,  Inc., 1966,
     MRID 000006172).

  c. Melting Point

     The melting point is  45-47°C (Rhodia,  Inc.,  19??,  MRID 000006651).

  d. Solubility

     At 25°C  (Rhodia, Inc., 19??,  MRID 000006113) phosalone is  practically
     insoluble in water, cyclohexane and petroleum  ether.   At 20 C (Laurent
     et al.,  1975, MRID  000006067) phosalone has  low water  solubility,
     approximately 1.7 ppm .  Freed et al.  (1979,  MRID  005018633) reported  the
     solubility as 2.15  ppm.  It  is soluble  in benzene,  dioxane, ethanol,
     methylene chloride, methanol, acetone, chloroform, acetonitrile, xylene
     and isophorone.

     The proposed registration guidelines state in  Section  163.61-8(4) that
     solubility data are required in g/100  ml of  solvent  at 20°C  (68°F) or
     in terms such as ppm  (mg/kg).

     Accordingly, the above solubility data, with the  exception of solubility
     in water, are inadequate  and further data  are  required.

  e. Stability

     Technical phosalone is an organophosphorus compound  relatively stable to
     heat  (up to 100°C)  and acid  media.  Hydrolysis occurs  under alkaline
     conditions, but more  slowly  than for many  other organophosphorus
     insecticides  (Desmoras et al.,  19??, MRID  000006968; Rhodia,  Inc.,  19??,
     MRID 000006113.)
                                       43

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    The rate of decomposition is a function of exposure  to UV light  and  is as
    follows:

    The constant of reaction rate under UV light  is  0.0081/sec and the
    half life is 86 minutes (Klisenko, M.A. and Pis'mennaya,  M.V., 1973,
    MRID 005014548).

 f. Octanol/Water Partition Coefficient

    The logarithm of the octanol/water partition  coefficient  at 20 C is  4.30
    (Freed et al., 1979, MRID 005018633).

 g. Physical State

    The physical state  is crystalline  (USA Standards Institute,  1967,
    MRID 000006668).

 h. Vapor Pressure

    The vapor pressure  of phosalone at 20  C is negligible; however,  specific
    figures are not available.  The phosalone concentration of a saturated
    atmosphere is <0.01 mg/m   (Desmoras et al., 19??, MRID 000006968).

    The registrant is required to supply the exact figures for vapor pressure
    in torr or mm Hg.   Thus, the data are  required.

 i. pH

    Since phosalone is  practically insoluble in water, no pH  data are  required.

 j. Storage Stability

    Results of stability studies on a technical lot  of phosalone stored  for
    six months and also for two years show that phosalone is  very stable under
    normal laboratory conditions for a period of  two years without risk  of
    notable degradation (Laurent et al., 1965, MRID  000006698).   The stability
    of bulk or formulated products is excellent.  ISb appreciable loss  in
    activity was observed in either normal temperature storage trials  or from
    a month of accelerated storage at 50°  (Rhodia, Inc., 19??,
    MRID 000006113).

k. Oxidizing or Reducing Action

    Under acidic conditions, no significant degradation  of phosalone takes
    place.  Under alkaline conditions, phosalone  is  not  stable and at  20°C
    exhibits a half life of about nine days (Laurent et  al.,  1975,
    MRID 000006067).
                                      44

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B. Data Gaps


Please refer to the data charts in Chapter III for the requirements, which
need to be fulfilled.
                                      45

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CHAPTER V: ENVIRONMENTAL FATE

    A. Use Summary
    B. Environmental Fate Profile
    C. Exposure Profile
    D. Data Gaps

A. Use Summary

Phosalone is an insecticide/miticide federally registered  for commercial use
to control a variety of insect and mite pests on  fruit,  nut,  vegetable,  and
ornamental crops.  Approximately 80 percent of phosalone applications are made
on pecans in the southeastern and southwestern states.   Other major application
sites are for apples in the eastern, western and  north central states, and for
grapes in California and Arizona.

Phosalone is formulated into a 25 percent active  ingredient wettable powder
formulation used predominantly on apples and grapes, and a 34.4 percent active
ingredient emulsifiable concentrate formulation used predominantly on pecans,
apples, and grapes.  Application rates for these  crops range  from 0.25-1.0
pounds active ingredient per 100 gallons of water (1.0-4.0 pounds active
ingredient per acre.) Both formulations are mixed with water  and  applied as
foliar applications with aircraft and ground equipment,  including air-blast
sprayers, hydraulic sprayers fitted with a single wand  (gun)  or boom,  and
others.  The type of equipment is determined by the site and  equipment
availability.

Approximately 1.5-2 million pounds active ingredient are imported annually
from  France.  No phosalone production is reported in the United States.—

B. Environmental Fate Profile

The environmetal fate studies which fulfill or partially fulfill  the data
requirements are discussed below.  They are grouped by topic  to correspond to
specific sections in the Guidelines.

1. Hydrolysis

Phosalone is stable over a pH range of 5-7, but is hydrolyzed at  pH 9 with a
half-life of nine days.  In a hydrolysis study at pH 9,  more  than 15 distinct
degradation products were found after four weeks. No single  degradation
product exceeded 10 percent of the applied phosalone.  Only four  degradation
products were identified:  phosalone-oxon, 6-chloro-benzoxazolone, 3-amino-7-
chloro-2-phenoxazone, and its precursor, 2-amino-5-chlorophenol (Laurent et
al.,  1975, MRID 000006067).

This  study, however, only partially fulfills the  hydrolysis data  requirement.
The guidelines require two temperatures and two concentrations to fulfill this


                                      46

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data requirement.  Therefore, a hydrolysis study using a concentration lower
than 1.5 ppm and at a temperature other than 20  C is needed to fully assess
the fate of phosalone in the water.

V No confidential business  information has been used to arrive at this EPA
   estimate of production volume.

2. Photolysis

Phosalone degrades in irradiated water and soil.  The data indicate half-lives
of 15-20 minutes and about one day, respectively, for water and soil.  In
irradiated water, approximately 20 degradation products have been isolated,
with hydroxyl-phosalone being the major degradation product.  Carbon dioxide,
6-chlorobenzoxazolone, and phosalone-oxon, were identified as minor degradation
products.  Aout 97 percent of the applied phosalone degraded in nonsterile
irradiated soil after one month.  Chly 30 percent degraded in sterile
clay loam soil under light, and 15 percent degraded in the dark.  Dechlorinated
phosalone and the oxygen analogue were the major degradation products found in
irradiated soil, and carbon dioxide was a minor product of photolysis (Anbrosi
et al., 1974, MRID 000006409; Mbrosi et al., 1977, MRID 000006666; Laurent et
al., 1977, MRID 000006665).

These studies fulfill the data requirement pertaining to the photodegradation
of phosalone.

3. Aerobic Soil Metabolism

Phosalone half-lives in soil metabolism studies ranged from less than one day
(type of soil unidentified) to seven days  (Beauce soil). Identified metabolites
were phosalone-oxon, 6-chlorobenzoxazolone, diethyldithiophosphoric acid,
diethylthionophosphoric acid, bis-0,0- diethylthionophosphoryl disulfide, 0,0-
diethyl thiophosphonyl disulfate, 0,0-diethylphosphonyl disulfate, and 3-amino-7-
chloro-2-phenoxazone.  The following degradation products were also rapidly
degraded in soil: dechlorinated phosalone, phosalone-oxon,
6-chlorobenzoxazolone, and 3-amino-7-chloro-2-phenoxazone.  Neither identified
nor unidentified polar and nonpolar extractable metabolites accumulated in
soil.  Uhextractable radiolabeled residues rapidly accumulated to 70-90 percent
of the applied   C phosalone under aerobic and flooded (semi-aerobic)
conditions.  The unextractable residues were associated primarily with the
fulvic acid fraction.  Ihder aerobic conditions, slightly less than 10 percent
of the applied   C phosalone was lost as carbon dioxide within one
month (Anbrosi et al., 1974, MRID 000006409; Anbrosi et al., 1977, MRID
00006664; Mibrosi et al., 1977, MRID 000006666; Ambrosi et al., 1977, MRID
005009356; /mbrosi et al., 1978, MRID 005008305; Desuoras et al., 1975, MRID
000006770.

These studies meet guideline requirements,  fbwever, the unextractable residues
interfere with development of a metabolic pathway.  For example, before


                                      47

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degradates are formed, the parent, and possibly some metabolites, are
unextractable.  Usually from 60 to 90 percent of total phosalone  is
unextractable, but is present in the soil and taken up by rotational crops.

These studies adequately characterize the aerobic  soil metabolism of phosalone
and fulfill all data requirements.

4. Microbial Metabolism:  Effects of Microbes on Pesticides

Microbial metabolism appears to be the primary mechanism responsible for
phosalone degradation  in soil, accounting for 60 to 86 percent  of its
degradation during a two or four week period.  The organisms responsible  for
the degradation, however, have not been  identified  (Ambrosi et  al., 1977, MRID
000006666 and Desmoras et al., 1975, MRID 000006770).

The above data partially fulfill Agency  requirements by demonstrating  the
role of microbial metabolism on phosalone degradation.  ND data are, however,
available on the identity of the organisms responsible for phosalone
degradation.

Despite the noted deficiency, the requirement for  the submission  of the
additional data is currently being reserved.  The absence of
acceptable data within this topic does,  therefore, not constitute a data  gap.

5. Microbial Metabolism:  Effects of Pesticides on Microbes

Limited data suggest that phosalone has  variable effects on microbes.  The
degradation of radiolabeled cytosine, glucose, glycine, guanine,  phenylalanine,
and urea in soil was only temporarily inhibited by phosalone treatment at 10
and 100 ppn.  At 1 ppn phosalone had no  effect on soil dehydrogenase activity
over an eight day period, whereas at 10  ppn activity was inhibited by  20
percent. Soybean nodule formation by Rhizobium japonicum was not  inhibited by
phosalone at _< 100 ppm.  Phosalone treatment of soil at 1 and 10  ppm enhanced
oxygen consumption over a six hour period.  Preliminary data also indicate that
nitrification and the  growth of bacteria may be slightly inhibited by
phosalone (Anbrosi et  al., 1976, MRID 000006667).

These data are not sufficient to satisfy this data requirement.   Rarther
information on the effects of phosalone  on important soil microbial functions
such as oxygen consumption, nitrification, denitrification, nitrogen fixation,
and microbial degradation of starch and  protein is needed.  This
requirement, like the  preceding, is currently being reserved.   Consequently,
the absence of acceptable data within this topic does not constitute a data gap.
                                       48

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6. Leaching

Phosalone  (  C radiolabeled)  did not  leach  from columns of  imaged  soils
loamy sand, sandy loam, clay  loam, and silt loam  (Anbrosi et al.,  1975,
MRID 000006663). The rapid  leaching study of parent material  (phosalone)  is
valid, but the aged portion of the study  is incomplete.  For example,   the
column was not leached  long enough (only  three days)  and the  identification of
metabolites was not reported.  Also,  the  method for identification of
metabolites was not mentioned.  The aged  soil should  be leached  for more  than
30 days and metabolites determined.   These deficiencies consistute a data gap
in the (aged) leaching  study.

7. 'Volatility

The vapor pressure of phosalone is not known.  Vhen this data gap  is filled, an
assessment can be made  concerning the need  for a  volatilization  study.

8. Accumulation in Rotational Crops

The current use pattern indicates that phosalone  is used to treat potatoes  and
artichokes as field crops.  Artichokes are perennials and are not rotated with
any other crop; however potatoes are  rotated with several other  field crops.

Data from rotational crop studies under greenhouse conditions indicate  that
phosalone and/or its metabolites can  accumulate in radishes, beans, potatoes,
and wheat planted 1.5 to 5.5  months after soil treatment with phosalone at  3
ppm  (Ambrosi et al., 1977,  MRID 000006664).

Due to the appearance of phosalone residues in greenhouse crops, field  studies
are required to determine if  residues would occur under actual use conditions.

In addition, all studies specified in Section 163.62-ll(b)  are needed for all
other crops identified  by the registrant  that may be  planted  in  rotation with
phosalone-treated crops.

If the registrant does  not  wish to have a rotational  crop restriction on a
phosalone product, one  of the following must be done:

   a. Supply environmental  fate data  supporting a rotation  interval which
       does not result  in a pesticide residue in  the  rotated crops; or

   b. Obtain a tolerance for  the nontarget crop (46 FR 3018); or

   c. Cbtain an exemption from a tolerance  for the nontarget crop.

In the interim a label  amendment restricting phosalone use  in crop rotation
                                      49

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programs will be required.   (See Chapter II for for a more detailed
discussion).

9. Fish Accumulation

Maximum bioaccemulation factors for catfish, crayfish, bluegill, and rainbow
trout were about 31, 21, 16. and 16, respectively following exposure at
<0.3 to 0.99 ug/liter of  [  C]phosalone over 28 days in a static system.
Residue levels in edible tissues declined to undetectable levels (<3 ppb)
between the 28th and 3rd day of exposure.  Depuration of residues  in nonedible
tissues was complete by day seven of the depuration period for all species
tested.  Therefore,  [  C]phosalone appears to exhibit a low bioaccunulation
potential in fish (Barrows, M.E., 1975, MRID 000006109).

Two exposure systems are required by the 1978 guidelines.  Therefore, an
additional study using a flow-through system and identifying radiolabeled
residues is needed to satisfy this data requirement.

10. Reentry

Reentry intervals are required to support the registration of all products for
which the Agency has determined that a reentry hazard exists for persons
reentering  treated sites.  Ihosalone is an acetyl-cholinesterase inhibiting
pesticide which may present a hazard to persons reentering treated fields.
The parent  and phosalone-oxon tend to persist, especially under dry conditions
and present a more hazardous reentry situation.

Popendorf et al., (1979, MRID 005005243) found a correlation between the amount
of dislodgable phosalone residues in peach orchards and the total dermal doses
of workers  in the orchard.   Ibwever, workers exposed to phosalone residue
levels up to 7 ug/cm  on peaches showed no blood cholinesterase depression.
Higher levels would not be expected to occur under actual use conditions.

Several studies presented the results of phosalone residue levels on grapes.
In one study, phosalone was applied at three pounds active ingredient per
acre twice within a five day period to grapes in California.  Levels of
dislodgeable foliar phosalone at harvest 87 to 98 days after the last
application were approximately 0.075 to 0.45 ug/cm   (Knaak et al., 1978 MRID
005003635).  Dislodgeable foliar phosalone and phosalone-oxon levels in another
study were  estimated at <0.1-4.8 and <0.1 to 0.83 ppm after 111-115 days,
respectively (Winterlin et al., 1978, MRID 005001343).  3h a separate field
sprayed with phosalone at three pounds active ingredient per acre, dislodgeable
foliar phosalone levels were estimated at 0.7 ug/cm  68 days after
application (Khaak et al., 1978, MRID 005003635).

TWo other studies in California showed that hot weather enhances phosalone's
dissipation on the surface of grape foliage treated with phosalone 3 EC at .2.1-
3 pounds active ingredient per acre.  In one study (Leffingwell et al., 1975,


                                      50

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MRID 005007745), dislodgeable phosalone, initially at approximately 175 ppm
(approximately  4 ug/on  ), had a half-life about seven days  in hot humid
weather  (up to  114  ), and a half-life of approximately  14 days  in cooler
weather  (95 to  105      .           .     .        ,   ,_  .....     , n   .  n
                    maximum).   In the other study  (Leffingwell  et al.,
MRID 005007744), about  25 to 65 percent of the dislodgeable phosalone
dissipated within seven to nine days when maximum  air temperatures were
generally >40   C  (104  ).  Vhen maximum  air temperatues  dropped  to 38  C
(100 F), the dissipation rate slowed and phosalone1s half-life  was >30 days.
The temperature effect  is probably due to enhanced volatilization and chemical
reaction.

In both  studies |he oxygen analogue accumulated to 2.5  to 6.5 ppm
(70 to 180 ng/cm  ) during the first eight days after phosalone  application.
The accumulation rate slowed thereafter and the level was relatively constant
at 6 to  10 ppn  (100 to  250 ng/cm ) 20 to 35 days after  application.  Neither
the decline pattern of  phosalone nor the accumulation of phosalone-oxon was
affected by variable spray concentrations that ranged from 2.25 pounds active
ingredient per  acre in  50 gallons of water to three pounds active ingredient
per acre in two gallons. However, the initial concentration of  dislodgeable
phosalone was higher with higher spray concentrations,  o^017 example,
dislodgeable phosalone  levels were about 10 to 16 ug/on one to two days
after application at three pounds active ingredient per acre in twelve gallons,
whereas  levels  were about 3 to 5 ug/on  one day after application at three
pounds active ingredient per acre in 50 gallons (Leffingwell et al., 1975,
MRID 005007745) or 2.25 pounds active ingredient in 23  to 30 gallons of water
per acre (Leffingwell et al., 1974, MRID 005007744).

All these studies show  that phosalone and phosalone-oxon residues are present
on crop surfaces several weeks after treatment with phosalone.  Thus a safe
reentry  interval must be established to protect persons reentering treated
fields from toxic effects of this cholinesterase inhibitor.  For each crop, the
registrant is required  to propose an acceptable reentry interval.  This
proposed interval may be based on the following:

   a. Data on dissipation of foliar residues (decline curve), on human
      exposure  to those residues; and on the inherent toxicity of phosalone;

   b. A determination of the time after which no detectable  foliar residues
      occur under appropriate climatic conditions, in the geographical
      area in which phosalone will be applied.

Phosalone is an organophosporothioate (OP) pesticide.   These OP pesticides
are among the most toxic pesticides used in American agriculture.  They
have caused the majority of the reported incidents of field worker
poisoning episodes, and most of these have been in  California.   Riosalone has
been implicated as a causative factor in a number of the incidents.   In
response to these poisoning incidents, reentry  intervals for phosalone have
been proposed twice by  the Occupational Safety and Health Administration of the


                                      51

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Department of labor and twice by the Environmental Protection Agency (EPA)
 [38  (83) Federal Register 10715; 38  (125) Federal Register 17211;  39 (48)
Federal Register 9457; 39 (92) Federal Register 16888, respectively.]   The  last
proposed reentry interval of  24 hours was established  for phosalone  in  40 CFR
170.  The State of California has established a seven day reentry  interval  in
response to the unusual environmental conditions within  that State with the
provision that the reentry interval would be waived, if  two inches of rain
occurred or if the equivalent of two inches of rain were applied to  the crop as
an overhead spray.  Khaaket al.  (1980, MRID GSOQ.27027) has proposed  that the
Reentry level for phosalone should be 7.0 ug/on  .

Guidelines for the establishment of Reentry Intervals will soon be proposed by
the  EPA.  V&thin those Guidelines it will be proposed  that reentry intervals
and  reentry (residue) levels will be required for the registration of any
pesticide that meets  certain  criteria.   Che of the criteria is that  the
pesticide has been implicated in poisoning incident(s).  Phosalone meets that
criteria.  The Agency is currently reviewing the established 24 hour reentry
interval for phosalone in the light of current scientific information and the
methodology presented in the  proposed Guidelines.

Until the Guidelines  and the reentry interval review is  complete,  the Agency
intends to maintain the 24 hour reentry  interval as an interim measure.  If
the  registrant wishes to appeal, interval data may be submitted to the
Agency  to support a change.

11.  Summary

Although  insufficient data are available to form a complete profile  of
phosalone1s environmental fate, the available information suggests that
phosalone will hydrolyze at moderately alkaline pH's and will rapidly
photodegrade in water.  In soil the degradation of phosalone occurs  mainly
by microbial action,  though some degradation results from photolysis. The half-
life of phosalone in  soil will generally range from less than one  day to seven
days. The major products of hydrolysis,  photolysis, and  soil metabolism are
phosalone-oxon, dechlorinated phosalone, 6-chlorobenzoxazolone, and  3-amino-7-
chloro-2 phenoxazone, all of  which are also rapidly degraded in soil.   At least
20 unidentified degradation products are formed in minute amounts.   The
microbial degradation of glucose, amino  acids, and urea  in soil is only
temporarily inhibited by phosalone treatment at concentrations higher than  the
recommended field dosage rate.   The compound does not  adversely affect  soil
dehydrogenase activity.  Phosalone and its metabolites will not leach through
most types of soils.   The potential for  accunulation of  phosalone  and  its
metabolites in fish is low. However, the identity of the residues  taken up  by
 fish is unknown.  Although phosalone rapidly dissipates  in soil, unidentified
residues may accumulate in radishes, beans, potatoes, and wheat planted as
rotational crops in treated fields. Although with adequate precautions
phosalone can be safely used, proper reentry intervals are necessary to avoid
potential hazards.
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C. EXPOSURE  PROFILE

1. Ml formulations

The use of airblast machines and aircraft  increases the potential  for exposure
via spray drift to humans, livestock or wildlife outside the application
site.  The potential for human exposure via groundwater contamination is  low,
as studies with several aged and unaged soils  (loamy sand, sandy loam, clay
loam and silt loam) show that phosalone does not leach.  The bioacc until at ion
potential is also low, with maximum bioaccemulation factors in catfish,
crayfish, bluegill, and rainbow trout reported at  31,  21, 16, and  16,
respectively.

The mixers and applicators of phosalone formulations have the highest potential
for direct exposure, but no quantitative data are  available to estimate the
degree of such exposure.  Dermal and eye exposure  from splashing during
diluting and mixing operations can result from the use of the emulsifiable
concentrate.  Respiratory exposure from "puff back" can occur during opening
and pouring of the wettable powder formulation.The precautionary statements
on the label regarding the use of protective clothing, gloves, and respirators
are adequate to ensure the safety of the mixers and applicators.

2. Vfettable Powder Formulation

One study was conducted to measure worker exposure to  phosalone
formulated as a wettable powder following entry into treated fields
(Popendorf et al., 1979, MRID 005005243). There was a  very good correlation
between estimated dermal dose and exposure to specific dislodgeable foliar
residues.  DLslodgeable foliar phosalone residues, at  harvest, ranged from
1,800 ng/cm   (22 to 24 days post application)  to 7,180 ng/cm   (seven to
nine days post application).  Dislodgeable phosalone-oxon residue  levels  were
one to three percent of the total phosalone applied and ranged from 24 to 190
ng/cm  , at harvest.  Vbrkers harvesting peaches 3  to 24 days after phosalone
applications, at four to five pounds active ingredient per acre received
estimated average dermal doses of phosalone and its oxygen analogue of 9.8  (7.2
to 13.9) and 0.16  (0.15 to 0.20) mg/hour, respectively.  Approximately 98 to 99
percent of the total dose was attributed to dermal rather than respiratory
exposure.  The estimated respiratory dose of phosalone was approximately  72
ug/hour.  The average individual shift in  red  blood cell cholinesterase
depression was eight to nine percent, well within  the  normal range of daily
fluctuations. Vforker red blood cell cholinesterase activity was slightly
inhibited (a mean of approximately four percent), when compared to an unexposed
control population.  This is not a toxicologically significant decrease.  Also,
there were no overt signs of cholinergic effects.
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3. Unspecified formulation

Orange trees in two adjacent fields in California were sprayed with an
unspecified formulation of phosalone at six pounds active ingredient per acre
in 600 gallons of water (Knaak et al., 1978, MRID 005008190).  Half-lives of  13
and 21 dayswere obtained for dislodgeable foliar phosalone at initial levels
of 6.4 and 7 ug/on  , respectively,  ftbrkers pruning trees 14 to 21 days after
application were exposed for three days to dislodgeable phosalone and oxygen
analogue at 2.6 to 3.6 and 0.2 to 0.5 ug/on , respectively.

Ifed blood cell cholinesterase activity in exposed workers was not significantly
different from unexposed controls.  Plasma cholinesterase activity of the
workers was significantly lower in both the 14 and 21 day studies.  Neither
phosalone nor its metabolites were detected in the urine of exposed workers
(limits of detectability for phosalone, phosalone oxon and 2-amino-5-
chlorophenol were 0.10, 0.10 and 0.16 ppm, respectively).

D. Data Gaps

Several studies are still needed to fulfill the data requirements for the
environmental fate of phosalone.  These data requirements include hydrolysis,
anaerobic soil metabolism, adsorption/desorption, terrestrial field
dissipation for field and vegetable crop uses and tree fruit and nut crop uses,
accunulation in rotational crops, and fish accunulation.

For labeling requirements regarding crop rotation and reentry intervals, please
refer to Chapter II.
                                      54

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CHAPTER VI: TOXICOLOGY

    A. Toxicology Profile - Manufacturing-Use Phosalone
    B. Toxicology Profile - End-Use Products
    C. Toxicology Profile - Oxygen Malogue
    D. ffezard Assessment - Manufacturing-Use and End-Use Products
    E. Data Gaps - End-Use Products

A. Toxicology Profile - Manufacturing-Use Phosalone

The studies which fulfill or partially fulfill the data requirements for
manufacturing-use phosalone are grouped by topics corresponding to the
appropriate section, which describes those requirements in the Guidelines.

1. Acute Oral Tbxicity

Sufficient data are available to show that phosalone has high acute oral
toxicity, which places phosalone in Tbxicity Category II (See Table 1).  Signs
of toxicity included salivation, lacrimation, muscle fasciculations,
convulsions, and respiratory disfunction which preceded death.  Most deaths
occurred within 24 hours of dosing.

Therefore, additional data are not required.

2. Acute Dermal Toxicity

There are sufficient data to demonstrate that the manufacturing-use formulation
has a high degree of acute dermal toxicity, which places phosalone in Tbxicity
Category  II.  The dermal LDcr, is 1530 ing/kg in rabbits with a minimum lethal
dose of 320 mg/kg  (Pasquet et al., 1976, MRID 005007746).  Deaths occurred
within four days of administration.  In a second study acute dermal LD™
values for rabbits and female rats were greater than 1000 mg/kg and 39o mg/kg,
respectively (Dubost et al., 1963, MRID 000006643).  Signs of toxicity were
characteristic of cholinesterase inhibition as described for acute oral
toxicity.  Deaths occurred within four days.

ISb further testing is needed.

3. Primary Eye Irritation

There is one supplementary eye irritation study (Dubost et al., 1963,
MRID 000006643).  It did not follow standard procedures and does not
fulfill this data requirment.

Therefore, data are still required.

There are data available for the EC formulation, which demonstrate
that phosalone is severely irritating to the eye  (HDrn et al., 1965,
MRID 000006690).  The registrant may use this study to fulfill the primary eye


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irritation data requiranent for the technical.  Bbwever, this would place the
technical grade material in Tbxicity Category I.  In this event the Agency
would require changes in the label, including a statement specifying the use of
protective goggles.

4. Subchronic Oral Tbxicity

Dog studies (Noel et al., 1970, MRID 000006111; Eonoso et al.,1967, MRID
000006203;  Fburnel et al., 1966, MRID 000006684; and Jones et al., 1967, MRID
000006205) indicate that a no-observed-effect-level with respect to plasma
cholinesterase inhibition is 25 ppn phosalone in the diet.  ND systemic effects
beside plasma cholinesterase inhibition vere observed in dogs given dietary
levels as high as 37.5 ppn for four weeks (Noel et al., 1970, MRID 000006111) .
No other subchronic study clearly characterized a no-observed-effect-level for
systemic effects, because lover doses were used (Eburnel et al.,196 8, MRID
000006684), or because higher doses (100, 200 and 1000 ppm) were administered
for a much longer time (two years) without effects  (Donoso et al., 1967, MRID
000006203).
 A test in a second species (preferably the rat) is also required by the
guidelines.  Although a rat study  (Dubost et al., 1963, MRID 000006643) was
conducted, it was  limited to male rats and was only five weeks in duration.
Also, it did not establish a no-observed-effect-level with respect to blood
cholinesterase inhibition in male rats.

However, the rat chronic feeding study (tobodard et al., 1967, MRID 000006202)
established a no-observed-effect-level.   (See Chronic Feeding Tbxicity.)
Therefore, there is no need for an additional rat study.

ISb further testing is required.

5. Subchronic Neurotoxicity

A subchronic neurotoxicity study (Vfoodard et al., 1966, MRID 000006695) shoved
that phosalone caused no demyelination at dietary levels up to 500 ppn in
chickens treated for 45 days.

ISb further testing is required.

6. Chronic Feeding Tbxicity

Sufficient data on chronic toxicity are available to indicate that phosalone
causes no systemic toxicity in rats fed diets containing 0, 25, 50, or 250 ppm
for two years (ftbodard et al., 1967, MRID 000006202).  A no-observed-effect-
level was established at 25 ppn phosalone in the diet for rats with respect to
red blood cell cholinesterase inhibition.

Nb further testing is required.
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7. Qicogenicity

There are sufficient data to show that phosalone does not have oncogenic
effects in rats (see previous section) at dietary levels as high as 250 ppm
(Vfoodard et al., 1968, MRID 000006202) and in mice at dietary levels as high as
ISOppn  (Fhone-Poulenc, 1980, MRID GS0027021.)  These studies are both
lifetime feeding studies.

tt> further data are needed.

8. Teratogenicity

There are data to demonstrate that phosalone is not  fetotoxic or teratogenic in
rats  (Khera et al., 1979, MRID 005008254) or rabbits (Pasquet, J. and Buisson
M., 1969, MRID 000006110) at daily doses as high as  15 or 18 mg/kg,
respectively.

Tnese two studies satisfy the minimum data requirement for teratology testing.

9. Reproductive Effects

A three generation reproduction study (Jones et al., 1967, MRID 000006204)
partially fulfills the data requirements for reproduction toxicity testing.
In this study groups of rats were given diets containing 0, 25, or 50 ppm
phosalone.  The study was compromised during the second and third generations
by the occurrence of a laboratory infection in test  animals.  In view of the
rapid metabolism and excretion (Collins, R.E. and Ings, R.M.J., 1967,
MRID  000006977, and Desmoras et al., 1968, MRID 000006715), the lack of
teratogenicity or fetotoxicity at high doses, which  are approximately 37 to 56
percent of the acute oral LA-0 in rats (Khera et al., 1979 MRID 05008254 and
Pasquet, J. and Buisson, M., 1969, MRID 000006110),  and the absence of
mutagenic activity in bacteria (Benazet, F. and Cartier, J.R., 1978,
MRID  GS0027020), the available studies are sufficient to fulfill testing
requirements for reproduction toxicity.  The no-observed-effect-level for
these effects is 50 ppm in the diet  (the highest level tested).

10. Mutagenicity

A bacterial assay (Benazet, F. and Cartier, J.R., 1978, MRID GS0027020) and a
dominant lethal test in mice (Goldenthal et al., 1978, MRID GS0027019)
indicate that phosalone is not mutagenic.  Although  these studies only
partially fulfill the data requirements, the results of the studies on
teratogenicity (Khera et al., 1979,  MRID 005008254 and Pasquet, J. and Buisson,
M., 1969, MRID 000006110), reproduction (Jones et al., 1967, MRID 000006204),
and oncogencity (Vfcodard et al., 1967, MRID 000006202; and Rhone-Poulenc,  1980,
MRID GS0027021) indicate that further testing is not necessary.  3h addition,
the rapid metabolism and excretion of phosalone and  its metabolites (Collins,


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R.E. and Ings, R.M.J. , 1967, MRID 000006977 and Dssnoras et al., 1968,
MRID 000006715) further support the decision to waive further testing
requirements.

11. Metabolism and Pharmacodynamics

The available data show that phosalone  is metabolized rapidly in the rat
(Collins, R.E. and Ings, R.M.J. , 1967, MRID 000006977 and Degnoras et al.,
1968, MRID 000006715).  Fifty percent of the administered dose  is metabolized
and excreted within 24 hours after treatment.  Metabolites included the oxygen
analogue, diethyldithio- and diethylthionophosphoric acids.  The heterocyclic
ring is also rapidly degraded to carbon dioxide, accounting for approximately
two- thirds of administered radiolabel (in the heterocyclic ring) in the rat
(Collins, R.E. and Ings, R.M.J., 1967, MRID 000006977).  Most of the remaining
activity is excreted in the urine.  Jn  vitro studies with liver tissues also
show that phosalone is metabolized to its oxygen analogue (Deanoras et al.,
1968, MRID 000006715).

Studies with mice demonstrate that 98 percent of the administered dose of
phosalone is excreted within 16 hours (Degnoras et al., 1968, MRID 000006715).

Studies with cows given phosalone labeled in the benzene ring showed that the
major route of excretion of administered radioactivity is in the urine.
Approximately 50 percent was excreted during the first 24 hours following
dosing (Qraine, E.M. , 1974, MRID 000006972 and 000006973).  A dermal
application of 13.9 milligrams of radiolabeled phosalone was applied to a pig
and showed that the chemical is not aosorbed through the skin (Craine, E.M. ,
1974, MRID 000006975).

Studies concerning cholinesterase inhibition are also available.  In one study
groups of 18 female rats were given a single oral dose of 0, 4, 12, or 36
milligram of phosalone per kilogram body weight (Pasquet et al., 1976,
MRID 005007746).  Qiol inesterase levels were measured at 2, 5, or 24 hours
after treatment in six animals from each group.  The dose required for
50 percent inhibition (ID™) of the cholinesterase activities are summarized
as follows:

                         ID5f)
   Type              at 2_ hours  _at 5_ hours

  Plasma                16.0              16.5
  Red blood cell        15.0              10.5
  Brain                 31                23

In another study by Eournel et al. (1968, MRID 000006716), groups of  18 rats of
each sex were given single oral doses of 0, 3, 9, or 27 milligram phosalone per
kilogram body weight or 1,3, or 9 milligram oxygen analogue per kilogram body


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weight.  Cne group of six animals of each sex was sacrificed  1.5,  6, or 24
hours after dosing and cholinesterase activities were measured  in  the blood
(plasma and erythrocytes) and the brain.  The investigators stated that peak
inhibition was seen between  1.5 and six hours after treatment.   The oxygen
analogue was shown to be a more potent inhibitor of cholinesterase than the
parent compound.

No further testing is necessary for metabolism and pharmacodynamics.

12. A3ditional Information

There are sufficient data to show that phosalone inhibits blood  cells
cholinesterase in calves given diets containing 0, 20, 50, 80 or 160 ppm
phosalone for eight weeks (Vfoodard et al., 1967, MRID 000006677).  The no-
observed-effect-level for this inhibition was 80 ppn.  ISb other toxic effects
were observed.   Gbws receiving diets containing 0, 25, 50 or 100 ppm phosalone
for 21 days showed no compound related effects  (Tbtmann et al., 1967,
MRID 000006073).

Phosalone in the diets of chickens at 31 or 115 ppm for four weeks decreased
egg production to 69.7 percent and 68.9 percent respectively, as compared
to 74.4 percent  for-untreated birds. Egg production in treated birds increased
when they were given diets without phosalone.  ISb other effects were noted
(McGinnis, C.H. , Jr., 1974,  MRID 000006976).  The no-observed-effect-level was
9 ppm with respect to egg production.  ISb effect on embryonated chicken
eggs were noted at doses as  high as 1.8 milligrams phosalone per egg
(highest dose tested) (Pasquet, J. and Buisson, M., 1969, MRID 000006110).

A study was conducted to determine the effectiveness of antidotes
against a lethal dose of phosalone in mice and rats (Rivett, K.F. and Davies,
V., 1966, MRID 000006697).   Che of the antidotes tested was P2S, which is the
chemical nane for l-methyl-pyridyl-2-aldoxine methyl sulphate.   It is an
analogue of 2-PAM, which is  suggested as an antidote for phosalone poisoning on
the label.  The other antidote tested was atropine.  Both chemicals are
classified as cholinesterase reactivators and as such are useful in reversing
the effects of cholinesterase inhibition caused by phosalone.   In this study
atropine was administered immediately after dosing, while P2S was
administered when signs of toxicity appeared.  P-S alone was  found to be a
more effective antidote than atropine alone.

B. Toxicology Profile-End-Use Phosalone

The studies which fulfill or partially  fulfill the data requirements for the
end-use products are grouped by Guideline requirements and are discussed below.

The requirements for acute dermal toxicity and acute inhalation  toxicity have
been fulfilled for the EC formulation.  These data will also  fulfill these
data requirements for the WP formulation.


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1. /cute Oral Tbxicity

Table 2 summarizes the acute oral LD^Q values  for  the  two  formulations, EC
and WP.  Signs appeared two hours after  dosing.  Deaths  occurred within 24
hours after treatment.  Rats given 147 mg/kg or greater  had  tremors  and
depression, while doses of  215 mg/kg  or  greater caused salivation and
lacrimation  (Scott, W.J. and Beliles, R.P., 1965,  MRID 000006688).   These
results  indicate that the formulations of  phosalone  have high acute
oral toxicity, placing it in Toxicity Category II.

No additional testing is required for either formulation.

2. Pcute Dermal Ibxicity

There are  sufficient  data to indicate that the acute dermal  toxicity of the
formulations  is moderate  (Toxicity Category HI).  The acute dermal  IA-Q
is greater than 2000  mg/kg  in male and female  rabbits  (Horn  et al.,  1965,
MRID 000006689).  ND  overt  signs of  systemic toxicity  or cholinesterase
inhibition were seen  in rabbits, and  only  mild erythema  was  seen in  rabbits
treated  with  the  2000 mg/kg dose.

 3. Pcute  Inhalation Tbxicity

There are  sufficient  data to indicate that the acute inhalation toxicity of
phosalone  formulations is relatively low (Toxicity Category  IV)  (Beliles,  R.P. ,
 1966, MRID 000006981).   Tne acute lethal concentration time  (LCT5Q)  vas found
to be 64 mg hr/liter  of air for  rats.

 4. Hrimary Eye  Irritation

There are  data  indicating that the emulsifiable concentrate  is severely
irritating to the eyes of rabbits  (tforn  et al., 1965,  MRID 000006690).   Gbrneal
opacity  persisted  in  some of the rabbits for seven days.  It should  be noted
that the treated eyes were  not vashed after instillation of  the formulation.

Tne Ajency will accept this study to fulfill this  data requirement,  even though
it was not conducted  for 21 days, as  specified in  the  guidelines.  This places
the formulation in Toxicity Category I.  Changes  in the current label should be
made, as discussed in Chapter II and  the guidance  package.   However, the
registrant may wish to submit additional studies,  which  are  conducted over the
21 day time period.   Such studies may result in a  lower  Toxicity Category.

There are  no  data available for  the  WP formulation.   Therefore, data are still
required.
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ffowever, the registrant may submit the data fron the EC formulation.  Again,
thip would place the WP in Ibxicity Category  I.  The appropriate changes  in the
label vould also be needed, including a statement concerning the use of
goggles.

5. Additional  Information

There is one stu3y of antidotes  in rats and mice which used lethal doses  of the
EC formulation administered orally  (Rivett, K.F. and Davies, V., 1966,
MRID 000006697).  The results are similar to  those described above for the
manufacturing use formulation.

C. Toxicology Profile-Oxygen Analogue

1. Acute Cral Tbxicity

The oral LDcQ  of the oxygen analogue  in  female rats was  21  mg/kg with 95
percent confidence  limits  of  12  to  28 mg/kg  (Pasquet et  al.,  1976,
MRID  005007746).   In male  rats the  oral  LD5Q  was  found to be  36 mg/kg with  a
confidence  interval from 29 to 44 mg/kg, wnile that for  female  rats was 20
mg/kg with  a confidence  interval from 15 to 29 mg/kg  (Fournel et al., 1968,
MRID  000006716).   Signs of toxicity were similar to those in animals treated
with  phosalone and  deaths  were seen within 24 hours of treatment with the
analogue.

Additional  information  is  available concerning the oral  lA-o  in mice.
Fburnel et  al.  (1968, MRID 000006716) reported 35 mg/kg  with  a  30 to 41 mg/kg
confidence  interval in males  and 40 mg/kg  with a  33 to 49 mg/kg confidence
interval for females.  Societe des Usines  Chimique Rione-Poulenc (1968,
MRID  000006674)  reported 32 mg/kg.   In  both cases the  signs of  toxicity were
indicative  of  cholinesterase  inhibition.

2.  Acute Eermal Toxicity

A dermal LDj-nin rats of  380 mg/kg was  reported by Pasquet et  al.  (1976,
MRID  005007/46)  with no  further  information.   These data suggest  that the
analogue is approximately  five times more toxic than the  technical  or the EC
formulation.

D.  Hazard Assessment for Manufacturing  and End-Use Products

The phosalone  exposure profile (refer to  Chapter V) provides  that maximum
exposure will  occur with those involved  in direct mixing, loading,  and
application.   The principal routes of exposure may be anticipated to be dermal
and inhalational; the  latter  coming from  applicator exposure  to spray mist.   As
noted above, the acute toxicity  of phosalone  falls within Categories  I through
IV, depending  upon  route of exposure and  formulation.  The  WP and EC acute  oral


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toxicity is relatively high, while acute dermal and inhalation toxicities are
moderate to low.   In addition, the acute oral and dermal toxicities of
phosalone-oxon is high.  The primary toxic effect of phosalone is its
cholinesterase inhibition.  Ihosalone, as demonstrated in a study with  the  EC
formulation, is also a severe eye irritant causing persistent corneal opacity,
if the chemical is not washed from the eye.  The Agency believes that the acute
hazards resulting from exposure to phosalone are mitigated by those
precautionary measures prescribed by the product labeling requirements  as
outlined in Chapter II.

Although the Agency does not possess the full complement of chronic toxicity
data as required by the Guidelines, those data available for Agency review do
not indicate any potential  for oncogenic, mutagenic, teratogenic, or
reproductive effects.  The  Agency, therefore, believes that phosalone, when
used according to label directions, presents no chronic hazard.

E. Data Gaps

Data gaps  for acute  inhalation toxicity, primary dermal irritation, primary eye
irritation, dermal sensitization, and acute delayed neurotoxicity should
be filled  for manufacturing-use phosalone.  Data for primary dermal irritation
and dermal sensitization are still needed for the EC and WP formulations.   Eata
concerning primary eye irritation are still needed for the WP formulation.
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CHAPTER VII. RESIDUE CHEMISTRY

     A.  Residue Gi em is try Profile
     B.  Data Caps

A. Residue Chemistry Profile

1. Metabolism in Plants

The metabolism  and degradation  of phosalone  follows  a  pattern  typical  of  that
of phosphorodithioate esters; i.e. oxidation to the  phosphate  (oxygen
analogue), hydrolysis and conjugation  of  the benzoxazolone  nucleous with  a
gylcoside and further elimination of this conjugate  (FAO Working  Party of
Experts on Pesticide Residues,  1973, MRID 005013895).   Phosalone  has been found
to directly hydrolyze although  oxidation  to the oxygen  analogue and then
hydrolysis of this metabolite is the more predominant  path  of  degradation
(Societe des Usines Cnimiques Fhone-Poulenc, 1968, MRID 000006675).
Experiments with de-ethylation  reactions  have  shown  that it is very unlikely
that de-ethylation of phosalone in plants will occur (Danoras  et  al.,  1968,
MRID 00006791).

The oxygen analogue of phosalone was detected  in  treated plants but always at
minute quantities usually about one percent of the total residue  and never
more than ten percent (Desmoras et al., 1968,  MRID 000006791). After
hydrolysis of phosalone or its  oxygen  analogue, the  diethyldithio- or
thionophosphoric acid leads  to  the formation of orthophosphoric acid  (Desmoras
et al., 1966, MRID 000006386 and Winterlin et  al., 1974, MRID  005009309).  Tne
benzoxazDlone nucleus of the molecule  or  6-chlorobenzoxazDlone has never  been
detected by itself.  However it was found as a conjugate of a  glycoside;  i.e.
[ (6-chloro-2-ben2DxazDlone)3-yl]-l-glicopyranose  (Desmoras  et  al., 1968,
MRID 000006791).

Phosalone is not regarded as "systemic";  however, when applied to the  soil it
will be absorbed and translocated by seme plants  (Kbvaleva,  E.S.  and Talanov,
G.A.,  1977, MRID 005014688).   It has been noted that grapes treated with
phosalone showed absorption of  phosalone  into  the pulp instead of being
retained on the skin  (Nalbandyan, R.A., 1975,  MRID 005016356).
                                                                   14
A study with potato plants, where the  leaves had  been  treated  with    C-
phosalone, showed that 99.5 percent of the radioactivity remained at the
treatment area.  The formed tubers contained less than 0.01 percent of
radioactivity 14 days after the treatment.   This  indicates  that there  is  no
translocation of phosalone out  of the  treated  area   (Mbrosi et al.,  1974,
MRID 000006125).

Accordingly it  is understood that the  nature of the  residue resulting  in
plants from a treatment of phosalone is as follows:  phosalone per se, its
oxygen analogue (usually one to ten percent  of the total residue) and  its


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hydrolysis products and [ (6-chloro-2-benzoxazDlone)-3-yl]-l-glucopyranose
present only in trace amounts.  The metabolism and degradation
pathways of phosalone in plants are veil defined and no further studies are
necessary.

2. fetabolism in Aiimals

In a study with animals (Desmoras et al., 1968, MRID 000006715)), rats and mice
were fed one dose of phosalone at 35 mg/kg and 50 mg/kg, respectively.  The
animals were sacrificed at varying time intervals after ingestion.  Samples of
urine, feces and of the whole body were taken for analysis. O/er 99 percent of
the ingested phosalone "disappeared" within 24 hours.  Aialysis also showed the
absence of any oxygen analogue of phosalone and 6-chlorobenzoxazolone
residues.  Thus, neither phosalone, its oxygen analogue, nor
6-chlorobenzoxa2olone were found in the tissues or excreta.

Important quantities of diethyl dithio- and thiono-phosphoric acids were
detected in the animal body, urine and feces indicating there was hydrolysis
of the phosalone molecule.  The 6-chlorobenzoxazolone residue was not
detected.

A metabolism study with dairy cattle (Craine, E.M., 1975, MRID 000006974) was
as performed to identify residues in .milk and urine following the
administration of a single dose of   C- benzene ring labeled phosalone.  Nb
tissues were analyzed.  The major route of elimination of phosalone residues
was reportedly via the urine (86-94 percent); the feces accounted for about
six percent of the remainder.  Oily 0.3 percent of   C - activity appeared in
the milk (i.e. 0.19 ppn.) Almost all (93-100 percent)  of the administered
  C - dose was recovered within 104 hours.
                                      14
In the urine about two percent of the   C in the dose was excreted as
phosalone per se or its oxygen analogue.  Two major urinary metabolites were
isolated and determined to be 2-oxo-3-mercaptomethyl-6-chlorobenzoxazole and
2-amino-5-chlorophenol.  The 2-oxo-3-mercaptomethyl-6-chlorobenzoxazole is
formed by hydrolytic cleavage of the S-P bond of phosalone and 2-anino-5-
chlorophenol could subsequently be formed by the hydrolytic opening of the
benzoxazole ring.  Another 15 compounds containing low levels of radioactivity
were present; however they were not identified.
                                             14
In milk less than 10 percent of the 0.19 ppm   C - activ ity present was
identified as phosalone or its oxygen analogue ( <0.02 ppm).  The major
metabolites found were 2-amino-5-chlorophenol (0.08 ppm) and 2-oxo-3-
mercaptomethyl-6-chlorobenzoxazole  (0.03 ppm).  Other compounds containing
radioactivity were also present but at levels too low to warrant
identification (0.03 ppm).
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The presence of these two compounds in milk caused the Agency to request  Rione-
Poulenc to submit additional methodology capable of measuring all
chlorobenaoxaaDle-and chlorophenol moiety-containing metabolites.  Such
methodology must be able to measure the  chlorophenol metabolite(s)  as separate
entities. Residue studies submitted in December of 1980  by  Rione-Poulenc
concerning meat, milk, poultry and eggs  in conjunction with  a pending
registration action for the use of phosalone  in or on alfalfa showed the
possible presence of residues  of  secondary phosalone metabolites.   These
studies are still awaiting final  review.

Metabolism data indicate that  phosalone  per se  is the primary residue of
concern after use of phosalone on raw agricultural crops.  The metabolism of
phosalone in animals is considered, however,  to be adequately defined at  the
present time.

3. Analytical Methodology

   a. Agricultural Crops

The following references discuss  chronologically the development of the
analytical method which was used  for the  collection of the majority of the
residue data on the agricultural  crops subject  to this   registration Standard:
Desnoras, J. , 1965, MRID 005016979; Guardigli, A., 1964, MRID 000006383;
Guardigli, A., 1968, MRID 000006703 and  GS0027010; Guardigli, A. and Melkesian,
B., 1968, MRID 000006083; Guardigli et al., 1967, MRID 000006678;  Guardigli  et
al., 1971, MRID 005008180; Laurent et al., 1967, MRID 000006700  and Societe
des Usines Chimiques Fhone-Poulenc, 1968, MRID 000006701.  This method, known
as Ihone-Poulenc's Method ISb.  54A, was also adopted as the regulatory
enforcement method and is therefore published in the Pesticide Analytical
Manual, tolune II, Section 120. 263.

Method ISb. 54A is the main method which  determines the concentration of the
parent compound present and consists of a gas chromatographic procedure.  Thin
layer chromatographic (TLC) methods (Rhone-Poulenc1 s Methods ISb. 54D and 54E)
are employed for the determination of the oxygen analogue of phosalone,  the
metabolite [ (6-chloro-2-ben2DxazDlone)-3-yl]-l-glucopyranose and may also be
used to confirm the presence of the parent compound.

In method Isb. 54A the residue  is  extracted from the crop with acetone and
buffered.  The solvent is evaporated.  The aqueous phase is  extracted with
methylene chloride.  The extract  is cleaned up by liquid partition on a
Florisil colunn.   After elution with ethyl acetate and evaporation, the residue
is dissolved in benzene.  The  amount of  pesticide is determined  with the  use
of a gas chromatograph utilizing  electron capture system.  This method is
supplemented by a TLC procedure for confirmatory purposes.
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Recoveries obtained in a method try-out on apples ranged from 74-91 percent
at 10 ppm and 95 percent at 20 ppm.  The sensitivity of the method is 0.1 ppm.

Overall, recoveries obtained at fortification levels from 0.25-2.0 ppm
averaged 92.5 percent.

When thin layer chromatographic methods 54D and 54E are employed, the final
cleaned-up extract in benzene is spotted versus standard solutions on a TLC
plate coated with  Silico Cfel GF254.  The plate is developed in the proper
elution median.  After air drying, the plate is sprayed with a 2N sodium
hydroxide solution and heated for five minutes at 120 C.  After cooling, the
plate is sprayed with a specific detection reagent.   Phosalone as low as
0.1 ppm in the presence of other pesticides can be detected.

   b. Meat and Milk

For the analysis of meat and milk samples, a modification of method ND. 54A is
used.  The modification consists of a change in the clean-up procedure.  This
modified procedure is known as method 54C (Guardigli, A., 1967, MRID 000006129;
1971, MRID 000006762; 1973, MRID 000006105.)  Although this method will
determine both phosalone and its oxygen analogue, this method was tried-out in
one of EPA's laboratories for phosalone only in beef fat.  Samples fortified at
0.25 ppm and 0.50 ppm of phosalone produced recoveries ranging from 88-92
percent and 92-98 percent, respectively.  The controls were <0.005 ppm.  The
method as tried out by Ibone-Poulenc1 s laboratory for milk at fortification
levels of 0.1-0.5 ppm of phosalone gave recoveries from 80-99 percent.
Recoveries from tissues at levels from 0.2-0.5 ppm ranged from 83-97 percent.
Control values were not more than 0.05 ppm in animal tissues and <0.0255 ppm in
milk.  The sensitivity of the method is estimated to be 0.1-0.2 ppm for meat
and milk.

Accordingly it is concluded that adequate methodology is available for the
collection of residue data and for enforcement purposes for measurement of
combined residues of phosalone and its oxygen analogue in and on raw
agricultural commodities including meat and milk.  Methods for phosalone
published in the Pesticide Analytical Manual are adequate for enforcement
purposes.  As previously mentioned, however, new methods are currently being
reviewed in a pending registration action concerning the use of phosalone in or
on alfalfa.

4. Residues in Plants and Anmals

The reported residue studies overall reflect the registered uses of phosalone
on raw agricultural crops, processed foods, by-products and feed items.
Feeding studies reflecting residues of phosalone in large animals and poultry
were adequate in exhibiting the possible transfer of residues of phosalone to
meat, milk, poultry and eggs.


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Ihe established tolerances for residues of phosalone which may result from
the registered uses are found adequate for the raw agricultural commodities as
well as the processed foods, by-products and feed items.  The established
tolerance (0.25 ppm) for meat, fat and meat by-products of cattle, goats,
hogs, horses and sheep is adequate to cover possible residues of phosalone
which may transfer to these commodities.

Itesidues in milk, poultry and eggs, resulting fron the registered uses of
phosalone are considered representative of category three of section 180.6(a);
i.e., it is not possible to establish with certainty whether finite residues
will be incurred, but there is no reasonable expectation of finite residues.

It is possible that the 0.25 ppn tolerance for residues of phosalone in the
meat, fat, and meat by-products of cattle, goats, hogs, horses and sheep, may
have to be raised in value and incluSe particular metabolites present in
tissues and milk, pending a registration action for phosalone use in or on
alfalfa.  (Please refer to chart in Chapter III for a listing of the citations,
which are grouped by the crop studied.)

5. Storage Stability

Several studies containing information on the storage stability of samples of
technical and formulated phosalone show that phosalone is very stable (Eeanoras
et al., 19??, MRID 000006968; Klisenki, M.A. and Pis'mennaya, M.V. , 1973,
MRID 005014548; Laurent et al., 1965, MRID 000006698 and Fhodia, Inc., 19??,
MRID 000006113).  (See Chapter IV, Product Chemistry, Physical/Chemical
Properties for a detailed discussion.)

6. Tolerance Levels

   a. Present U.S. Tolerances

      1). Raw Agricultural Gbmmodities

According to 40 CFR 180.263 tolerances for residues of phosalone, in or on raw
agricultural commodities are as follows:

         50 ppn in or on almond hulls.
         25 ppn in or on artichokes.
15 ppm in or on apricots, cherries, nectarines,
            peaches, and pluns (fresh prunes).
         10 ppm in or on apples, grapes, and pears.
         3  ppn in or on citrus fruit.
                                      67

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0.25 ppn in the meat,  fat,  and meat by-products of
            cattle, goats,  hogs, horses, and sheep.
       0. Jppn (negligible residue)  in or on almonds
            and potatoes.
 0.05 ppn (negligible residue) in or on brazil
            nuts, bush nuts, butternuts, cashews, chestnuts, filberts,
            hazelnuts, hickory nuts, macadamia nuts,  pecans and walnuts.

      2). Processed Foods

Also according to 21 CFR 561.300, tolerances for residues of phosalone are
established in or on the following  processed foods, when present therein as a
result of the application to growing crops:

         8 5 ppn in or on dried apple pomace.
         45 ppm in or on dried grape pomace.
         12 ppm in or on dried citrus pulp.

In addition, according to 21 CFR 193.340 tolerances are established for
residues of the insecticide phosalone in or on the following processed foods
when present therein as a result of application to the growing crops;

         4 0 ppn in or on dried prunes.
         20 ppm in or on dried raisins.
          8 ppn in or on dried tea.

   b. CODEX Tolerances

A list of suggested maxdmun limits in ppm for residues of phosalone on an
international basis is exhibited below.

These limits were a result  of joint meetings on lesticides Ifesidues in 1972,
1975, and 1976.  The Acceptable Daily Intake (ADI)  was calculated to be 0.006
mg/kg body weight.
                                      68

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 CODEX Tolerances
                                        Maximum  (ppn)  for
         Conmodity                      Phosalone  Residues
         /pples                                  5
         Beet roots                              2
         Broccoli                                1
         Brussels grouts                        1
         Cabbage                                  1
         CherrieslO
         Chestnuts 0.1(*)
(Shell-free Basis)

         Citrus Fruit                            1
         Cucumber                                1
         Grapes                                  5
         fops (Dried)                             2
         Lettuce                                 1
         Iteaches                                  5
         Pears                                   2
         Ifeas                                    1
         Pecans                                  0.1(*)
(9iell-free Basis)

         Plums                                   5
         Potatoes                                O.K*)
         Rapeseed                                0.1(*)
         Sleep, Eat                              0.5
         Sheep, Carcass Meat                     0.05(*)
         Stravfcerries                            1
         Tomato                                  1
   (*)Level at or about the limit of determination
                                      69

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A comparison of the U.S. tolerances with the CODEX tolerances indicates that
most of the U.S. tolerances are remarkably higher than  the  CCDEX tolerances.  A
reassessment of the U.S. tolerances indicates that it is  impractical  to lover
the U.S. tolerances due to the level of residues that result from  the
registered use in the U.S.

Some CODEX tolerances are higher, however.   For example,  the CODEX tolerance
for residues of phosalone in the fat of sheep  (0.5 ppm) is  twice that of  the
U.S. (0.25).  This is because the CCDEX tolerance reflects  residues resulting
from a "sheep-dip" use, a use which is not registered in  the U.S.

The U.S. tolerance for animal fat reflects phosalone residues resulting from
feeding the animals crops treated with phosalone; this  use  is not  considered
under the international tolerance.  The U.S. tolerance  for  phosalone  in meat,
fat, and meat by-products of cattle, goats, hogs, horses, and sheep is being
reevaluated due to the pending registration action for  use  in or on alfalfa.

The CODEX tolerance of 0.1 ppm for pecans and chestnuts (nuts) is  also higher
than that of the U.S. tolerance of 0.05 ppm  for nuts (except almonds) .  Both
tolerances are based on the sensitivity of the method used.   The U.S. tolerance
is a negligible tolerance and could be made consistent  with the  CODEX
tolerance (i.e. 0.1 ppm) for the nut grouping (except almonds) as  defined  under
Title 40, section 180.34(f), which states in part,

         "It may be possible to make a reliable estimate of negligible
         residues of pesticide chemicals to be expected on  each  commodity in a
         designated grouping on the basis of data on a  representative number of
         commodities listed in the following designated groups."

The commodities listed for nuts include Brazil nuts, bush nuts,  butternuts,
cashews, chestnuts, filberts, hazelnubs, hickory nuts,  macadamia nuts, pecans,
and walnuts.

A change in the tolerance to a higher level, however, is  dependent upon a
recalculation of the Theoretical Maximum Residue Concentration  (TMRC).  The
Agency recalculated the TMRC and found that  it would be appropriate to make
the U.S. tolerance for nuts (except almonds) consistent with the CODEX
tolerance of 0.1 ppm.  The result is discussed in Chapter 2 under  the
Tolerance Reassessment Section.

7. Special local ISeed Registrations

In 1980, additional uses for the application of phosalone by aircraft to
almonds, grapes, stone fruit and walnuts were granted by  California  under
Section 24  (c) of FIFRA, which provides for a state to  obtain additional  uses
to meet special local needs. The maximum use per acre for all crops is the
same as for those applied by ground equipment except the  spray volume for the
aerial application can be reduced to a minimum of 20 gallons of  water.  Vfe have


                                      70

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reviewed the data reflecting the residues resulting fron the ground
applications and in conjunction with the fact that  F.D.A. Market Basket
Surveillance data report residues of phosalone considerably below the
established tolerances; it  is  concluded that the registered Section 24  (c)  uses
are in compliance with the  respective established crop tolerances.

B. Data Gaps

No generic data gaps were identified with regard to Ffesidue Chemistry.
                                       71

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CHAPTER VIII: ECOLOGICAL EFFECTS

     A. Ecological Effects Profile
     B. Hazard Evaluation
     C. Data Gaps

A. Ecological Effects Profile

Phosalone, as noted earlier in the Use Summary section of  Chapter  V,  is  an
insecticide and miticide applied to agricultural and commercial ornamental
crops.  It may be applied by ground or aerial equipment  to agricultural  sites
and by ground equipment to ornamentals.  As a result of  these methods of
application, some potential exists for the exposure of nontarget terrestrial
and aquatic organisms.

1. Birds and Aquatic Invertebrates

In relation to the toxicity of phosalone to birds and aquatic  invertebrates,
limited data are available.  However, these studies are  considered  inadequate,
because they failed to meet guideline requirements.  It  is thus not
possible to assess phosalone1 s toxicity to these nontarget organisms.
Therefore, data are still required.

2. Fish

With respect to the toxicity of phosalone to fish, the available data  indicate
that it may be highly toxic to both warmwater (McCann, J.A. and
Jasper, R.L. , 1972, MRID 005009810; USDA, 1969, MRID GS0027002) and coldvater
fishes  (USDA, 1969, MRID GS0027001). The USDA study (MRID   GS0027001) reports
a 96 hour 1C 5Q of 0.92 ppm  for coldwater fishes.  This  study was  conducted
with a  34.8 percent active ingredient formulation and characterizes
this formulation as being highly toxic to coldvater fishes.  The
studies concerning the warmwater fishes (MRID 005009810  and GS0027002) ware
also conducted with the 34.8 percent active ingredient formulation.  These
studies did not report an 1C J-Q value, but did indicate  high toxicity.
However, the proposed guidelines require that the studies  be conducted with the
technical product, in order to evaluate the effect of the  chemical  itself  on
fishes.  Studies performed with technical material facilitate extrapolation for
all formulations.  Therefore, data are still required with technical phosalone
on both warmwater and coldwater fishes.

3. Plants

The data base concerning the toxicity of phosalone to nontarget plants and
microorganisms is somewhat limited. Information on the effects of
phosalone applied at the recommended rates on citrus, stone fruits,
nuts, apples, grapes and potatoes is available.  These data show no adverse
effects on the plants tested.
                                      72

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Several vegetables for which phosalone is not registered were tested under
greenhouse conditions and showed  injury.  Cucunber,  however, was  the
only plant tested under both greenhouse and field conditions, and displayed no
phytotoxic symptoms when treated  at one pound active ingredient per acre  for
the field test. This was twice the rate applied  in the greenhouse study.   The
results from the  field study reflect  the potential exposure of plants  to
phosalone more accurately, and the Agency, consequently, ass ones  that  the
affected vegetables would be more tolerant  in the  field.

The label indicated a potential for injury on roses,  although no valid studies
were received to  confirm this.

Although the studies mentioned above  were not conducted under the
specifications of the proposed guidelines (40 FR 72910; November  3, 1980), the
Agency has determined that the studies, in aggregate, provide sufficient
information to fulfill the data requirement for  vegetative vigor  for
dicotyledonous plants.  These studies adequately describe the phytotoxic
effects of phosalone to these plants.  (Please refer  to the Chapter III charts
for ecological effects for the citations.)  To completely fulfill this data
requirement, however, data must still be submitted for representative
monocotyledonous  plants.  The data requirements  for  effects on seed
germination, algae, and aquatic macrophytes must also be met, because no
studies were either submitted or  located in the  literature.

4. Soil and Terrestrial Invertebrates

With respect to phosalone's  toxicity  to nontarget  soil and terrestrial
invertebrates, the available information shows that  the adverse effects of
phosalone to phytoseiid predaceous mites are highly  variable and  species
specific  (Croft, B.A. and Stewart, P.G., 1973,  MRID  005009346; Croft, B.A. and
Nelson, E.E. , 1972, MRID 005009345; Karg, W., 1978,  MRID 005020178; Nelson et
al., 1973, MRID 005005773; Vfetve, C.M. and Lienk,  S.E., 1975, MRID 005013359;
Witve, C.M. and Lienk, S. E., 1976, MRID 005014275).

Available information indicates that  phosalone is moderate in toxicity to honey
bees, Apis mellifera  by either direct spray or residual contact (Atkins,  E.L.
and Anderson,  L. D., 1967, MRID 000006654; Atkins et  al., 1970, MRID 000006653;
Atkins et al., 1973, MRID 000006652;  Grahame, R. E.,  1967, MRID 000006657;
Smyth, E.P. and Jbhansen, C., 19??, MRID 000006793).  Si addition, a residual
contact test for  wild bees was conducted with the  leafcutter bee, Megachile
pacifica, and the alkali bee, Nomia melanderi  (Smyth et al., 19??,
MRID 000006793) and low toxicity  was  demonstrated. This low to moderate
toxicity to pollinators may  be mitigated by restricting application to times
when bees are not actively foraging.  See Chapter  II for appropriate label
statements.
                                       73

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ALthough these data concerning nontarget soil and terrestrial invertebrates are
quite limited, they appear adequate for current hazard labeling
needs.  Additional studies may, however, be required upon the promulgation of
the Guidelines Subpart L, ffezard Evaluation:  ISbntarget  Insects.

B. Hazard Assessment

Due to the limited amount of information available, a detailed hazard
assessment for wildlife cannot be made at this time.  There is an indication
that phosalone does not present a serious hazard to dicotyledonous plants.
There is also an indication that phosalone may be highly toxic to warmwater and
coldwater fishes and low to moderately toxic to pollinators.

C. Data Gaps

Tests to assess the ecological effects of phosalone are required, with
the exception of the vegetative vigor requirement for dicotyledonous plants.
Please refer to the data charts in Chapter III for the specific requirements.
                                      74

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                            IX.  CASE BIBLIOGRAPHY

                       Guide to Use of This Bibliography

1.  Content of Bibliography.  This bibliography contains citations  of  all  the
    studies reviewed by EPA in arriving at the positions and conclusions stated
    elsewhere in this standard.  Primary sources for  studies in  this
    bibliography have been the body of data submitted to EPA and  its
    predecessor agencies in support of past regulatory decisions, and  the
    published technical literature.  The bibliography is divided  into  two
    sections:  (1) citations that contributed information  useful  to the
    review of the chemical and are considered to be part of the  data base
    supporting registrations under the standard and  (2) citations that have  been
    examined and judged to be inappropriate for use in developing the  standard.

2.  Units of Entry.  The unit of entry in this bibliography is called  a
    "study".  In the case of published materials, this corresponds  closely to
    an article.  In the case of unpublished materials submitted  to  the Agency,
    the Agency has sought to identify documents at a  level parallel to a
    published article from within the typically larger volumes in which they
    were submitted.  The resulting "studies" generally have a distinct title
    (or at least a single subject), can stand alone for purposes  of review,  and
    can be described with a conventional bibliographic citation.  The  Agency
    has attempted also to unite basic documents and commentaries  upon  them,
    treating them as a single study.

3.  Identification of Entries.  The entries in this bibliography are sorted
    by author, date of the document, and title.  Each entry bears,  to  the  left
    of the citation proper, a nine-digit numeric identifier.  This  number  is
    unique to the citations and should be used at any time specific reference
    is required.  This number  is called the "Master Record Identifier" or
    "MRID".  It is not related to the six-digit  "Accession Number", which  has
    been used to identify volumes of submitted data;  see paragraph  4(d)(4)
    below for a further explanation.  In a few cases, entries added to the
    bibliography late in the review may be preceded by a nine-character
    temporary identifier.  This is also to be used whenever a specific
    reference is needed.

4.  Form of the Entry.  In addition to the Master Record Identifier (MRID),
    each entry consists of a bibliographic citation containing standard
    elements followed, in the case of materials submitted  to EPA, by a
    description of the earliest known submission.  The bibliographic
    conventions used reflect the standards of the American National Standards
    Institute (ANSI), expanded to provide for certain special needs.   Some
    explanatory notes of specific elements follow:
                                       75

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a.   Author.  Whenever the Agency could confidently  identify one,  the
     Agency has chosen to show a personal author.  When  no  individual  was
     identified, the Agency has shown an identifiable laboratory or testing
     facility as author.  As a last resort, the Agency has  shown the first
     known submitter as author.

b.   Document Date.  When the date appears as  four digits with no
     question marks, the Agency took it directly  from the document.  When a
     four-digit date is followed by a question mark, the bibliographer
     deduced the date from evidence in the document.  When  the date appears
     as  (19??), the Agency was unable to determine or estimate the date of
     the document.

c.   Title.  This is the third element in the  citation.  In some cases it
     has been necessary for Agency bibliographers to create or enhance a
     document title.  Any such editorial insertions  are  contained  between
     square brackets.

d.   Trailing Parentheses.  For studies submitted to us  in  the past, the
     trailing parentheses include (in addition to any self-explanatory
     text) the following elements describing the earliest known
     submissions:

     (1)  Submission Date.  Immediately following the word  'received1
          appears the date of the earliest known submission, at the time
          that particular document was processed  into the Pesticide
          Document Management System.

     (2)  Administrative Number.  The next element,  immediately following
          the word  'under', is the registration number,  experimental permit
          number, petition number, or other administrative  number
          associated with the earliest known submission, at the time that
          particular document was processed into the Pesticide Document
          Management System.

     (3)  Submitter.  The third element is the submitter, following the
          phrase  'submitted by'.  When authorship is defaulted to  the
          submitter, this element is omitted.

     (4)  Volume Identification.  The final element  in the  trailing
          parenthesis identifies the EPA accession number of the volume in
          which the original submission of the study appears.   The six-
          digit accession number follows the symbol  'CDL1,  standing for
          "Company Data Library".  This accession number is in turn
          followed by an alphabetic suffix which shows the  relative
                                  76

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position of the study within the volume.  For example, within
accession number 123456, the first study would be  123456-A;  the
second, 123456-B; the 26th, 123456-Z; and the 27th,123456-AA.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006409   Ambrosi, D.; Buys, M.; Desmoras, J.; Laurent, M.; Sasmayoux, ?;
               Savary, ? (1974) Insecticides: Degradation of Phosalone  (RP
               11974) under Ultra-Violet Light: S.U.C.R.P.—D.S.Ph./
               D.S.An. Nord No. 17761.  (English translation; unpublished study
               received Mar 24, 1975 under 3F1337; prepared by Societe des
               Usines Chimiques Rhone-Poulenc, submitted by Rhodia, Inc.,
               New Brunswick, N.J.; CDL:093574-Q)

000006664   Ambrosi, D.; Desmoras, J.; Blanchard, ?; Leteve, ?; Savary, ?
               (1977) Insecticides: Phosalone: Study on Persistence of  Re-
               labelled Phosalone in Soil: Rotational Crops: R.P./R.D./
               C.N.G. No. 19040.  (Unpublished study received May 10, 1977
               under 359-620; prepared by Societe des Usines Chimiques Rhone-
               Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth Junction,
               N.J.; CDL:229759-D)

000006666   Ambrosi, D.; Desmoras, J.; Blanchard, ?; Savary, ? (1977) Phosa-
               lone: Photodegradation in Soil: R.P./R.D./C.N.G. No. 19046.  In-
               cludes undated method.  (Unpublished study received May 10, 1977
               under 359-620; prepared by Societe des Usines Chimiques Rhone-
               Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth Junction,
               N.J.; CDL:229759-F)

000006667   Ambrosi, D.; Desmoras, J.; Huguet, ? (1976) Insecticides: Phosa-
               lone: Effects on Soil Microorganisms: R.P./R.D./
               C.N.G. No. 18787.  (Unpublished study received May 10, 1977 un-
               der 359-620; prepared by Societe des Usines Chimiques Rhone-
               Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth Junction,
               N.J.; CDL:229759-H)

000006663   Ambrosi, D.; Desmoras, J.; Huguet, ?; Lingart, ?; Savary, ? (1976)
               Herbicides: Phosalone: Studies on Leaching in Different Soils:
               R.P./R.D./C.N.G. No. 18752.   (Unpublished study received May 10,
               1977 under 359-620; prepared by Societe des Usines Chimiques
               Rhone-Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth Junc-
               tion, N.J.; CDL:229759-C)

000006125   Ambrosi, D.; Desmoras, J.; Savary, M.  (1974) Phosalone: Transloca-
               tion Study in Potato Plants Using 14C-Labelled Phosalone:
               S.U.C.R.P.—D.S.Ph. No. 17416.   (Unpublished study received Feb
               12, 1974 under 4E1468; prepared by Societe des Usines Chimiques
               Rhone-Poulenc, submitted by Interregional Research Project
               No. 4, New Brunswick, N.J.; CDL:093909-C)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

005008305   Ambrosi, D.; Isensee, A.R.; Macchia, J.A. (1978) Distribution of
               oxadiazon and phosalone in an aquatic model ecosystem.  Journal
               of Agricultural and Food Chemistry 26(1):50-53.

005009356   Ambrosi, D.; Kearney, P.C.; Macchia, J.A. (1977) Persistence and
               metabolism of phosalone in soil.  Journal of Agricultural and
               Food Chemistry 25(2):342-347.   •

000006652   Atkins, E.L.; Greywood, E.A.; Macdonald, R.L.  (1973) Toxicity of
               Pesticides and Other Agricultural Chemicals to Honey Bees:
               Laboratory Studies.  Rev.  By Univ. of California, Dept. of
               Entomology.   Riverside, Calif.: U.C.  (Agricultural Extension
               M-16; also In unpublished submission received Nov 17, 1975 un-
               der  359-620; submitted by Rhone-Poulenc, Inc., Monmouth Junc-
               tion, -N.J.; CDL:223344-A)

000006654   Atkins, E.L., Jr.; Anderson, L.D.  (1967) Toxicity of Pesticides and
               Other Agricultural Chemicals to Honey Bees: Laboratory Studies.
               Rev.  By"Univ. of California, Dept of Entomology.   Riverside,
               Calif.: U.C.  (Agricultural Extension M-16; also In unpublished
               submission received Nov 17, 1975 under 359-620; suEmitted by
               Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:223344-D)

000006653   Atkins, E.L., Jr.; Anderson, L.D.; Nakakihara, H.; Greywood, E.A.
               (1970) Toxicity of Pesticides and Other Agricultural Chemicals
               to Honey Bees: Laboratory Studies.  Rev.  By Univ. of Califor-
               nia, Dept. of Entomology.   Riverside, Calif.: U.C.   (Agricul-
               tural Extension M-16; also _In unpublished submission received
               Nov  17, 1975 under 359-620; submitted by Rhone-Poulenc, Inc.,
               Monmouth Junction, N.J.; CDL:223344-B)

000006109   Barrows, M.E. (1975) Kinectics  [sic] of 14C-Phosalone in a Model
               Aquatic Ecosystem.  (Unpublished study received Mar 4, 1976
               under 6F1753; prepared by EG&G, Bionomics,  submitted by Rhodia,
               Inc., Monmouth Junction, N.J.; CDL:095979-H)

000006981   Bellies, R.P. (1966) Phosalone  (R.P. 11974): Safety Evaluation by
               Acute Inhalation Exposure of Rats.   (Unpublished study received
               Dec  15, 1966 under 7G0575; prepared by Woodard Research Corp.,
               submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
               CDL:090729-C)

GS0027020   Benezet, F.; Cartier;, J.R. (1978) Phosalone  (11,974 R.P.)-
               Mutagenicity Study on Salmonella typhimurium.  R.P./R.D./C.N.G.
               Report No. 19 234 E.   (Unpublished transaltion of study
               received Dec 4, 1980 under 6F1753; submitted by Rhone-Poulenc,
               Inc., Monmouth Junction, NJ; CDL:099788)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

005005128   Brun, G.L.; Surette, D.; Mallet, V. (1973) A new method for  the
               detection of organophosphorus pesticides by in situ fluorometry
               on thin-layer chromatograms.  International Journal of
               Environmental Analytical Chemistry 3(1):61-71.

000014256   Ciarletta, J.A.; Smith, R.L.; Sleesman, J. (1975) Moni-
               tor (R): Efficacy, Phytotoxicity and Yield Effects on Peppers.
               (Unpublished study including report nos. 31525, 31659, 31726,
               31735, 32153, 36254, 36258, 36259, 36337, 36342, 36345, 36346,
               39118, 39140, 39799, 40064, 40729, 40946, 41098, 42715, 42880,
               42916, 43225, 43379 and 44930, received Aug 24, 1978 under 3125-
               280; submitted by Mobay Chemical Corp., Agricultural Div.,
               Kansas City, Mo.; CDL:097315-A)

000006977   Collins, R.F.; Ings, R.M.J.  (1967) Phosalone (11,974 R.P.):  Metabo-
               lism and Residue Study in Rats (Preliminary Study with 14C-(2)-
               Phosalone): BIOCHEM/352.  (Unpublished study received Mar 4,
               1976 under 6F1753; prepared by May & Baker, Ltd., submitted by
               Rhodia, Inc., Monmouth Junction, N.J.; CDL:098088-U)

000006978   Collins, R.F.; Roxburgh, J.  (1967) Phosalone (11,974 R.P.):  Studies
               of Levels  in the Skin and Edible Tissues of Sheep: Gas-Liquid-
               Chromatography  (G.L.C.) Determinations: BIOCHEM/353.   (Unpub-
               lished study received Mar 4, 1976 under 6F1753; prepared  by May
               & Baker, Ltd., submitted by Rhodia, Inc., Monmouth Junction,
               N.J.; CDL:098088-V)

000006972   Craine, E.M.  (1974) Disposition of Phosalone-14C in a Lactating
               Cow: Research Report No. EMC 74:17.  (Unpublished study received
               Mar 4, 1976 under 6F1753; submitted by Rhodia, Inc., Monmouth
               Junction, N.J.; CDL:098088-M)

000006973   Craine, E.M.  (1974) Disposition of Phosalone-14C in a Lactating
               Cow: Research Report No. EMC 74:84.  (Unpublished study received
               Mar 4, 1976 under 6F1753; submitted by Rhodia, Inc., Monmouth
               Junction, N.J.; CDL:098088-N)

000006975   Craine, E.M.  (1974) The Disposition of Phosalone-14C Applied to the
               Skin of a  Pig: Research Report No. EMC 74:30.   (Unpublished
               study received Mar 4, 1976 under 6F1753; submitted by Rhodia,
               Inc., Monmouth Junction, N.J.; CDL:098088-P)

000006974   Craine, E.M.  (1975) The Metabolism of Phosalone-14C in Dairy Cows:
               Research Report No. EMC 75:51.  (Unpublished study received Mar
               4, 1976 under 6F1753; submitted by Rhodia, Inc., Monmouth Junc-
               tion, N.J.; CDL:098088-0)

005009345   Croft, B.A.; Nelson, E.E.  (1972) Toxicity of apple orchard
               pesticides to Michigan populations of Amblyseius fallacis.
               Environmental Entomology  1(5):576-579.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

005009346   Croft, B.A.; Stewart, P.G.  (1973) Toxicity of one carbamate and
               six organophosphorus insecticides to O-P resistant strains
               of Typhlodromus occidentalis and Amblyseius fallacis.
               Environmental Entomology 2(3):486-488.

000006735   Crouch, R.V. (1970) Phosalone  (11974 R.P.): Residue Studies on Tea
               (Green Leaf): Pakistan 1969: Report No. RG/758.  (Unpublished
               study received Jun 8, 1973 under 3H5038; prepared by May &
               Baker, Ltd., submitted by Rhodia, Inc., New Brunswick, N.J.;
               CDL:221773-H)

000006528   DeLay, D.L. (1968) Report No. PA 68-43.   (Unpublished study re-
               ceived Feb 16, 1970 under OF0948; submitted by Rhodia, Inc., New
               Brunswick, N.J.; CDL:092026-H)

000006569   DeLay, D.L. (1969) Summary Report: District Project No. PA 69-15.
               (Unpublished study received Feb 16, 1970 under OF0948; submitted
               by Rhodia, Inc., New Brunswick, N.J.;  CDL:092026-BB)

000006534   Delay, D.L. (1969) Summary Report: District Project No. PA 69-29.
               (Unpublished study received Feb 16, 1970 under OF0948; submitted
               by Rhodia, Inc., New Brunswick, N.J.;  CDL:092026-Q)

000006069   Dennis, S.  (1973) Phosalone—Dried Grape  Pomace Data.  Includes
               undated method.  (Unpublished study including residue final re-
               port no. 170473-092, received Jul 26,  1974 under 5H5058; sub-
               mitted by Rhodia, Inc., Somerset, N.J.; CDL:221786-A)

005016979   Desmoras, J. (1965) Dosage biologique de  la phosalone ou 11.974
               R.P.: application a 1"etude de la degradation de la phosalone
               dans les plantes et le sol.  [Biological determination of
               phosalone or 11,974 R.P.: application  to the study of
               degradation of phosalone in plants and in the soil.]
               Mededelingen van de Landbouwhogeschool en de Opzoekingsstations
               van de Staat te Gent.   [Communications of the Agricultural
               University and the State Research Station of Ghent.]
               29(3):1221-1234.

000006770   Desmoras, J.; Ambrosi, D.; Savary, ? (1975) Phosalone: Degradation
               in Sterile and Non-Sterile Soil Using  14C-Labelled Phosalone:
               R.P./R.D./Biol—No.22.   (Unpublished study received Mar 24,
               1975 under 3F1337; prepared by Societe des Usines Chimiques
               Rhone-Poulenc, submitted by Rhodia, Inc., New Brunswick, N.J.;
               CDL:093574-J)

000006209   Desmoras, J.; Buys, M.; Laurent, L. (1973) Phosalone Residues in
               Tea: S.U.C.R.P.—D.S.Ph./D.S.An.Nord No. 17389.  (Unpublished
               study received on unknown date under 3H5038; prepared by Societe
               des Usines Chimiques Rhone-Poulenc, submitted by Rhodia, Inc.,
               New Brunswick, N.J.; CDL:221773-A)

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000006715
               OFFICE OF PESTICIDE PROGRAMS
            REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
             Registrations Under the Standard

 Desmoras, J.; Fournel, J.; Bredenbach, ?; Savary, ?  (1968) Studies
    on Degradation of Phosalone in Mammals: R.P.—D.S.Ph. No.  12667.
    (Unpublished study received Jun 14, 1968 under 8F0668; prepared
    by Societe des Usines Chimiques Rhone-Poulenc, submitted by
    Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:091171-AK)
000006707
000006968
 Desmoras, J.; Laurent, M.; Aublet, ?; Sasmayoux, ?; Savary,  ?
    (1968) Phosalone: Determination of Phosalone, 12244 R.P.  and
    20650 R.P. in Fruit from the U.S.A.: R.P.—D.S.Ph./D.S.An.Nord
    No. 12850.  (Unpublished study received Jun 14, 1968 under
    8F0668; prepared by Societe des Usines Chimiques Rhone-Poulenc,
    submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
    CDL:091171-1)

 Desmoras, J.; Laurent, M.; Buys, M.  (19??) Phosalone.  Pages 385-
    397, T_n Analytical Methods for Pesticides and Plant Growth Regu-
    lators—Thin Layer and Liquid Chromatography and Analyses of
    Pesticides of International Importance: Volume VII.  Edited by
    G. Zweig.   New York: Academic Press.  (Also In unpublished sub-
    mission received Mar 4, 1976 under 6F1753; submitted by Rhodia,
    Inc., Monmouth Junction, N.J.; CDL:098088-1)
000006791   Desmoras, J.; Laurent, M.; Sauli, M.; Terlain, B.  (1968) Metabolism
               study of Phosalone in plants and soils.  Phytiatrie-Phytopharma-
               cie 4:263-275.  (Presented at the VI International Congress
               for the Protection of Plants, Vienna, 8-30-67 to 9-6-67;
               also _In unpublished submission received Jun 13, 1974 under 359-
               620; submitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.;
               CDL:120351-C)

000006386   Desmoras, J.; Laurent, M.; Terlain, B.; Aublet, J.C.; Sasmayoux,
               J.C.; Savary, M. (1966) Study of the Metabolism of Phosalone
               (11974 R.P.) in Plants: R.P.—D.S.Ph. No. 11686.   (Unpublished
               study received Feb 2, 1967 under 7G0575; prepared by Societe des
               Usines Chimiques Rhone-Poulenc, submitted by Chipman Chemical
               Co., Inc., Burlingame, Calif.; CDL:090727-E)

000006203   Donoso, J.; Woodard, M.W.; Woodard, G.  (1967) Phosalone: Safety
               Evaluation by Repeated Oral Administration to Dogs for  107
               Weeks.   (Unpublished study received Oct 17, 1967 under  7G0575;
               prepared by Woodard Research Corp., submitted by Chipman  Chemi-
               cal Co., Inc., Burlingame, Calif.; CDL:090731-A)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006643   Dubost, P.; Fournel, J.; Ganter, P.; Julou, L.; Koenig,  F.; Myon,
               J.; Bredenbac, J.; Lemoine, F. (1963) Acute Toxicity, Local Tol-
               erance, Anticholinesterase Activity and Chronic Toxicity in Rats
               and Dogs: R.P.—D.S.Ph. 9203.  (English translation;  unpublished
               study received 1965 under 359-EX-46; prepared by Societe des
               Usines Chimiques Rhone-Poulenc, submitted by Rhone-Poulenc,
               Inc., Monmouth Junction, N.J.; CDL:123396-D)

005015711   Eckenrode, C.J.; Robbins, P.S.; Webb, D.R. (1975) 1974 Insecticide
               Research Report on Cabbage Maggot, Seedcorn Maggot, Aphids on
               Lettuce, and Phytotoxicity in Cucumbers.  Geneva, N.Y.:  New
               York State Agricultural Experiment Station.  (New York State
               Agricultural Experiment Station, plant sciences: entomology
               (Geneva), no. 9; New York's food and life sciences bulletin no.
               56)

005013895   FAO Working Party of Experts on Pesticide Residues (1973)
               Phosalone.  Pages 493-520, In 1972 Evaluations of Some
               Pesticide Residues in Food.  By the Joint Meeting of  the FAO
               Working Party of Experts on Pesticide Residues and the WHO
               Expert Committee on Pesticide Residues.  Geneva, Switzerland:
               World Health Organization. (WHO pesticide residues series no.
               2)

000006684   Fournel, J.; Ganter, P.; Julou, L.; Populaire, P.; Myon, J.;
               Pascal, S.; Pasquet, J. (1966) Phosalone (11974 R.P.): Toxicity
               after 6 Months Administration to Dogs: R.P.—D.S.Ph.  No. 11410.
               (Unpublished study received Dec 12, 1966 under 7G0575; prepared
               by Societe des Usines Chimiques Rhone-Poulenc, submitted by
               Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090728-C)

000006716   Fournel, J.; Julou, L.; Pasquet, J.; Bredenbac, J. (1968) 12244
               R.P.: Acute Toxicity in Mice and Rats and in Vivo Anti-Choli-
               nesterase Activity in Rats: R.P.—D.S.Ph. No. 12663.  (Unpub-
               lished study received Jun 14, 1968 under 8F0668; prepared by
               Societe des Usines Chimiques Rhone-Poulenc, submitted by Chip-
               man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-AL)

005018633   Freed, V.H.; Chiou, C.T.; Schmedding, D.; Kohnert, R.  (1979) Some
               physical factors in toxicological assessment tests.
               Environmental Health Perspectives 30:75-80.

GS0027019   Goldenthal, E.I.; Jessup, D.C.; Rodwell, D.E.  (1978) Dominant
               Lethal Study in Mice.  (Unpublished study received Dec 12, 1980
               under 6F1753; prepared by International Research and  Development
               Corp., submitted by Rhone-Poulenc, Inc., Monmouth Juntion, NJ;
               CDL:099788)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006657   Grahame, R.E., Jr. (1967) The Conparative Toxicity of Selected
               Organic Phosphate and Carbamate Insecticides to the Honey Bee.
               Master's thesis, Univ. of Massachusetts.  (Unpublished study re-
               ceived Nov 17, 1975 under 359-620; submitted by Rhone-Poulenc,
               Inc., Monmouth Junction, N.J.; CDL:223344-K)

000006383   Guardigli, A. (1964) Chemical Determination of R-P-11974 (Phosa-
               lone) for Crop Residues.  Method no. 54 dated Oct 2, 1964.  (Un-
               published study received Feb 2, 1967 under 7G0575; submitted by
               Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090727-A)

000006389   Guardigli, A. (1964) Laboratory Analytical Data Sheet for Residues
               of R.P. 11974: Phosalone.  (Unpublished study received Feb 2,
               1967 under 7G0575; prepared by Rhodia, Inc., submitted by Chip-
               man Chemical Co., Inc., Burlingame, Calif.; CDL:090727-H)

000006769   Guardigli, A. (1964) Laboratory Analytical Data Sheet for Residues:
               Field Test Project No. BB 64-26.   (Unpublished study received
               Feb 2, 1967 under 7G0575; prepared by Rhodia, Inc., submitted
               by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090727-L)

000006388   Guardigli, A. (1965) Residue Summary Sheet:  [Phosalone].  (Unpub-
               lished study including project nos. BB 10-64-12, BB 12-64-20,
               BB 64-26, BB 65-18, BB 65-27, BB 65-47, BB 65-49, BB 65-127,
               C 64-12, C 65-17, C 65-30 and Port 65-47, received Feb 2, 1967
               under 7G0575; prepared by Rhodia, Inc., submitted by Chipman
               Chemical Co., Inc., Burlingame, Calif.; CDL:090727-G)

000006391    Guardigli, A. (1966) Laboratory Analytical Data Sheet for
               Residues: Field Test Project No. BB 66-126.  (Unpublished study
               received Feb 2, 1967 under 7G0575; prepared by Rhoda, Inc.,
               submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
               CDL:090727-J)

000006714   Guardigli, A. (1966) Laboratory Raw Analytical Data.  (Unpublished
               study including letter dated Feb 9, 1965 from L. Farber  to L.
               Reed and test nos. BB-64-26, BB-65-125, C-64-12, C-65-27, Port-
               65-66 and Port 66-12, received Jun 14, 1968 under 8F0668; pre-
               pared by Rhodia, Inc., submitted by Chipman Chemical Co., Inc.,
               Burlingame, Calif.; CDL:091171-AD)

000006392   Guardigli, A. (1966) Residue Summary Sheet:  [Phosalone].  (Unpub-
               lished study including project nos. BB 64-26, BB 65-125, C 64-
               12, C 65-27, Port 65-66 and Port 66-12, received Feb 2,  1967
               under 7G0575; prepared by Rhodia,  Inc., submitted by Chipman
               Chemical Co., Inc., Burlingame, Calif.; CDL:090727-K)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006390   Guardigli, A. (1966) Residue Summary Sheet:  [Phosalone].   (Unpub-
               lished study including project nos. C-64-12 and BB-65-63,  re-
               ceived Feb 2, 1967 under 7G0575; prepared by Rhodia,  Inc.,  sub-
               mitted by Chipman Chemical Co., Inc., Burlingame, Calif.;  CDL:
               090727-1)

000006395   Guardigli, A. (1966) Residue Summary Sheet:  [Phosalone].   (Unpub-
               lished study including project nos. C 64-16, C 65-44, BB 65-42
               and BB 65-51, received Feb 2, 1967 under  7G0575; prepared  by
               Rhodia, Inc., submitted by Chipman Chemical Co., Inc., Burlin-
               game, Calif.; CDL:090727-0)

000006129   Guardigli, A. (1967) Analytical Procedure for Phosalone  Residue
               Determination in Milk and Animal Tissues  by Electron  Capture
               Chromatography.  Method no. 54-C dated Aug 14, 1967.   (Unpub-
               lished study received Oct 17, 1967 under  7G0575; prepared  by
               Rhodia, Inc., submitted by Chipman Chemical Co., Inc., Burlin-
               game, Calif.; CDL:090733-B)

000006713   Guardigli, A. (1967) Laboratory Raw Analytical Data.   (Unpublished
               study including letter dated Mar 2, 1965  from L. Farber to L.
               Reed and field test project nos. BB-65-63, BB-67-100, C 64-12,
               and PA 67-28, received Jun 14, 1968 under 8F0668; prepared  by
               Rhodia, Inc., submitted by Chipman Chemical Co., Inc.,
               Burlingame, Calif.; CDL:091171-Z)

000006703   Guardigli, A. (1968) Determination of RP 11974  (Phosalone) for Crop
               Residue by Electron Capture Chromatography.  Rev.   Method  no.
               54-A dated Mar 20, 1968.  (Unpublished study received Jun  14,
               1968 under 8F0668; prepared by Rhodia, Inc., submitted by  Chip-
               man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-D)

GS0027014   Guardigli, A. (1968)  [Phosalone residue analyses on citrus and
               nut crops.  (Unpublished study received   Apr 19, 1968 under
               OF0948 Part D; submitted by Rhodia, Inc.)

GS0027015   Guardigli, A. (1968)  [Phosalone residue analyses on citrus and nut
               crops.]  (Unpublished study received Apr  19, 1968  (PA66-63) and
               Sep 26, 1969 (PA66-73) under OF0948; submitted by Rhodia,  Inc.)

GS0027016   Guardigli, A. (1968)  [Phosalone residue analyses on citrus and nut
               crops.]  (Unpublished study received Apr  19, 1968  (PAS66-57),
               Oct 10, 1969 (PA69-19), Oct 6, 1969  (PA69-19), Feb  6,  1970 (PA19-
               19), Jan 22, 1970  (PA69-19), Oct 6, 1969  (PA69-19 Decline
               Series), and Dec 15, 1969(Westlake Report, University of
               California at Riverside) under OF0948; submitted by Rhodia, Inc.)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

GS0027010   Guardigli, A. (1968) Rhodia Analytical Method No.  54-D.
               Quantitative Determination of Phosalone by GLC  and  Semi-
               Quantitative Determination of RP 1224  (Phosalone  Oxygen
               Analog) in Crop Extracts by Thin Layer Chromatography.
                [Unpublished report based on Rhone-Poulenc D.S. Ph. No.  12773.]
               foliage.  Bull. Environm. Contam. Toxicol. 24:  796-804.

000006711   Guardigli, ^A. (1968) Results of Tests on the Amount  of Residue Re-
               maining.  (Unpublished study including letters  dated  Dec  9,
               1964, Jan 21, 1965 and Oct 1, 1965 from L. Farber to  L. Reed
               and field test nos. BB-10-64-12, BB-64-10, BB-64-26,  BB-65-47,
               BB-65-49, BB-65-127, C-64-12, C-65-17; C-65-30, C-66-32,
               C-66-33, PA-66-32, PA-67-58 and Port-65-47, received  Jun  14,
               1968 under 8F0668; prepared by Rhodia, Inc., submitted by Chip-
               man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-N)

000006170   Guardigli, A. (1968) Specific Analytical Method for  Phosalone
               Liquid  Formulations  (Zolone E.G.): Determination  by Gas Liquid
               Chromatography.  Method no. 54-A dated May 1968.   (Unpub-
               lished  study received Jan 16, 1969 under 359-620; prepared by
               Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth  Junc-
               tion, N.J.; CDL:124065-A)

000006640   Guardigli, A. (1969) Determination of RP 11974  (Phosalone)  in Wet-
               table Powder Formulation.  Method no. 54-A 2 dated  Dec 1969.
                (Unpublished study received Dec 22, 1969 under  359-626; prepared
               by Rhodia, Inc., submitted by Rhone-Poulenc, Inc.,  Monmouth
               Junction, N.J.; CDL:003174-AF)

000006762   Guardigli, A. (1971) Method of Analysis of Phosalone and Its Oxygen
               Analog  (RP 12244) in Animal Tissues by TLC.  Method no.  54-C 1
               dated Jun 1, 1971.   (Unpublished study received Jun 26,  1972
               under OF0983; submitted by Rhodia, Inc., New Brunswick, N.J.;
               CDL:091691-1)

000006068   Guardigli, A. (1972) Phosalone Transfer  in Fruits  Processing:
               Possible Residue in Raw Apple Juice and Dry Apple Pomace: Labo-
               ratory  Experiments.   (Unpublished study received  Feb  16,  1972
               under 2H5013; submitted by Rhodia, Inc., New Brunswick,  N.J.;
               CDL:221747-C)

000006105   Guardigli, A. (1973) Electron Capture Gas Liquid Chromatography
               Determination of Phosalone and  Its Oxygen Analog  in the  Milk
               and Tissues of Dairy Cattle.  Revised Method 54-C dated  Apr
               1973.   (Unpublished  study received May 15,  1973 under 2F1193;
               submitted by Rhodia,  Inc., New  Brunswick, N.J.; CDL:093518-AC)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006971   Guardigli, A. (1973) Residue Studies in the Milk and Tissues of
               Dairy Cows Fed Phosalone.  (Unpublished study received Mar  4,
               1976 under 6F1753; submitted by Rhodia, Inc., Monniouth Junction,
               N.J.; CDL:098088-L)

005008180   Guardigli, A.; Chow, W.; Martwinski, P.M.; Lefar, M.S.  (1971)
               Determination of phosalone and its oxygen analog in  citrus
               crops.  Journal of Agricultural and Food Chemistry
               19(4):742-744.

000006783   Guardigli, A.; Martwinski, P. (1969) Phosalone Residues on Apples
               Treated with Zolone 25% Wettable Powder at Several Application
               Rates.  (Unpublished study including field test project nos. AT
               69.16-AT 69.17, BB 68-66, BB 69.7-BB 69.9, Port 68-12 and Port
               69-56, received Dec 22, 1969 under 359-626; prepared by Rhodia,
               Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junction,  N.J.;
               CDL:003174-W)

000006358    Guardigli, A.; Martwinski, P. (1970) Results of Almond Residue
              Tests: Part D.  (Unpublished study including field test project
              nos. PAW 69-5, PAW 69-6, PAW 69-9, PAW 69-13, PAW 69-18 and  PAW
              68-18, received Jun 26, 1972 under OF0983; submitted  by Phodia,
              Inc., New Brunswick, N.J.; CDL:091691-J)

000006511   Guardigli, A.; Martwinski, P. (1970) Results of Residue Tests.
               (Unpublished study including report nos. AT 69-14, AT 69-20, AT
               69-22, AT 69-47, PA 67-45, PA 68-50, PA 69-29, PAS 67-77, PAW
               69-2 and PAW 69-7, received Mar 12, 1970 under OF0948; submitted
               by Rhodia, Inc., New Brunswick, N.J.; CDL:091617-B)

000006480   Guardigli, A.; Martwinski, P. (1971) Residue Data:  [Zolone].   (Un-
               published study including field test project nos. BB 65-63, BB
               68-91, PA 68-46, PA 70-25/25A, PA 70-26, PA 70-27/27A and PAW
               70-29, received Nov 18, 1971 under 359-626; prepared by Rhodia,
               Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junction,  N.J.;
               CDL:003175-X)

000006576   Guardigli, A.; Martwinski, P. (1972) Phosalone—Potato  Petition:
               Residue Summary—Potatoes.  (Unpublished study including field
               test project nos. AT 71-15, BB 68-87, BB 68-94, BB 69-60, C 66-
               41, CH 71-61, CH 71-84, CH 71-103, FW 71-52 and Port 71-30,
               received May 25, 1973 under 3F1337; submitted by Rhodia, Inc.,
               New Brunswick, N.J.; CDL:093575-E)

000006083   Guardigli, A.; Melkesian, B. (1968) Detection of Metabolites in
               Grapes Sprayed with Excessive Amounts of Phosalone  (PA-68-30).
               (Unpublished study received Sep 12, 1968 under 9F0759; submitted
               by Rhodia, Inc., New Brunswick, N.J.; CDL:091306-AC)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006084    Guardigli, A.; Rock, G. (1968) Detection of the Oxygen Analog  (RP
               12244) in Apples (AT-68-10).  (Unpublished study received Sep
               12, 1968 under 9F0759; prepared in cooperation with North
               Carolina State Univ., submitted by Rhodia, Inc., New Brunswick,
               N.J.; CDL:091306-AD)

000006678   Guardigli, A.; Taschenberg, E.F.; Stafford, E.M. (1967) Laboratory
               Analytical Data Sheet for Residues: Field Test Project No. BB
               67-100.  (Unpublished study including field test project no. PA
               67-25, received Jun 14, 1968 under 8F0668; prepared by Rhodia,
               Inc., submitted by Chipman Chemical Co., Inc., Burlingame,
               Calif.; CDL:091170-F)

000006964   Henckler, P. (1973) Project Number 170473-008.  (Unpublished study
               including letter dated Nov 6, 1973 from D.I. Wang to C.C. Comp-
               ton, received Oct 18, 1973 under 3E1401; prepared by Rhodia,
               Inc., submitted by Interregional Research Project No. 4, New
               Brunswick, N.J.; CDL:098195-A)

000006107   Henckler, P. (1973) Specific Analytical Method for Technical Phosa-
               lone and Its Formulations: Liquid and Wettable Powders.  Method
               no. 124 dated Nov 1973.  (Unpublished study received Mar 4, 1976
               under 6F1753; submitted by Rhodia, Inc., Monmouth Junction,
               N.J.; CDL:095979-D)

000006483   Henckler, P.M.; Dennis, S. (1973) Residue Summary: Apricots.  (Un-
               published study including residue final report nos. 170473-042
               and 170473-053, received Mar 29, 1974 under 359-620; prepared by
               Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junc-
               tion, N.J.; CDL:028124-C)

000006484   Henckler, P.M.; Dennis, S.; Collins, R. (1973) Residue Summary:
               Cherries.   (Unpublished study including residue final report
               nos. 170473-041 (A), 170473-041. (B) and 213673-013, received Mar
               29, 1974 under 359-620; prepared by Rhodia, Inc., submitted by
               Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:028124-D)

000006485   Henckler, P.M.; Rice, R. (1973) Residue Summary: Nectarines: Pro-
               ject No. 180473-032.  (Unpublished study received Mar 29, 1974
               under 359-620; prepared by Rhodia, Inc. in cooperation with
               Univ. of California, submitted by Rhone-Poulenc, Inc., Monmouth
               Junction, N.J.; CDL:028124-E)

000006487   Henckler, P.M.; Rice, R. (1973) Residue Summary: Plums: Project
               No. 180473-033.  (Unpublished study received Mar 29, 1974 under
               359-620; prepared by Rhodia, Inc. in cooperation with Univ. of
               California, submitted by Rhone-Poulenc, Inc., Monmouth Junction,
               N.J.; CDL:028124-G)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006486   Henckler, P.M.; Taylor, J.C.; Corner, G.; Dennis, S.  (1973) Residue
               Summary: Peaches.  (Unpublished study  including residue final
               report nos. ARK 72-77, 123973-023 and  170473-072,  received Mar
               29, 1974 under 359-620; prepared by Rhodia, Inc. in cooperation
               with Louisiana State Univ. and Clernson Univ., submitted by
               Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:028124-F)

000006689   Horn, H.J.; Woodard, M.W.; Woodard, G. (1965) Phosalone R.P. 11974:
               Acute Dermal Toxicity  for Rabbits.  (Unpublished study received
               Dec 15, 1966 under 7G0575; prepared by Woodard Research Corp.,
               submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
               CDL:090729-D)

000006690   Horn, H.J.; Woodard, M.W.; Woodard, G. (1965) Phosalone R.P. 11974:
               Acute Eye Irritation in Rabbits.   (Unpublished study received
               Dec 15, 1966 under 7G0575; prepared by Woodard Research Corp.,
               submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
               CDL:090729-E)

005006342   Ishitani, A.; Yukimoto, M.; Yoshida, K.  (1975) Nogaku no
               kakushusakubutsu ni taisuru yakugai ni tsuite: II.  Yuki rinkei
               satchuzai.   [Phytotoxicities of agricultural chemicals to
               crops: II.  Organophosphorus insecticides.]  Noyaku Kensasho
               Hokoku.   [Bulletin of  the Agricultural Chemicals Inspection
               Station.] (15):92-97.

000006204   Jones, M.E. ; Post, K.F..;  Scott, W.J.; Woodard, M.W. ;  Woodard, G.
               (1967) Phosalone: Three-Generation Reproduction Study in the
               Rat.  (Unpublished study received Oct  17, 1967 under 7G0575;
               prepared by Woodard Research Corp., submitted by Chipman Chemi-
               cal Co., Inc., Burlingame, Calif.; CDL:090732-A)

000006205   Jones, M.E.; Woodard, M.W.; Imming, R.J.; Woodard, G. (1967) Phos-
               alone Followed by a Determination of  Potentiation  Activity with
               the Compound Di-Syston.   (Unpublished  study received Oct 17,
               1967 under 7G0575; prepared by Woodard Research Corp., submitted
               by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090734-A)

005020178   Karg, W. (1978) Untersuchungen zur Selektivitaet von
               Pflanzenschutzmitteln  im Hinblick auf  nuetsliche,  Spinnmilben
               vertilgende Raubmilben im Obsthau.   [Investigation on thhe
               selectivity of plant protection chemicals with regard to
               beneficial predatory mites destroying  spider mites in orchards.]
               Archiv fuer Phytopatholigie und Pflanzenschutx 14(1):41-55,

005008254   Khera, K.S.; Whalen, C.;  Angers, G.; Trivett, G.  (1979) Assessment
               of the teratogenic potential of piperonyl butoxide, biphenyl,
               and phosalone in the rat.  Toxicology and Applied  Pharmacology
               47(2):353-358.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

005014548   Klisenko, M.A.; Pis'mennaya, M.V. (1973) Vliyanie UF-sveta na
               stabil'nost1 dialkilditiofosfororganicheskii pestitsidov.   [The
               effect of ultraviolet light on the stability of
               dialkyldithioorganophosphorus pesticides.]  Khimiya v Sel'skom
               Khozyaistve.  [Chemistry in Agriculture.] 11(12):916-918.

GS0027027   Knaak, J.B. (1980)  Minimizing occupational exposure to pesticides:
               Techniques for estimating safe levels of foliar residues.   Pages
               81-96, In  Residue Reviews, Volume 75.  By F.A  and J.D.
               Gunther, editors.  New York:  Springer-Verlag New York Inc.

005008190   Knaak, J.B.; Maddy, K.T.; Gallo, M.A.; Lillie, D.T.; Craine, E.M.;
               Serat, W.F. (1978) Worker reentry study involving phosalone
               application to citrus groves.  Toxicology and Applied
               Pharmacology 46(2):363-374.

005003635   Knaak, J.B.; Peoples, S.A.; Jackson, T.J.; Fredrickson, A.S.;
               Enos, R.; Maddy, K.T.; Blair Bailey, J.; Duesch, M.E.; Gunther,
               F.A.; Winterlin, W.L. (1978) Reentry problems involving the use
               of dialifor on grapes in the San Joaquin Valley of California.
               Archives of Environmental Contamination and Toxicology
               7(4):465-481.

000006938   Knobel, H.; Rock, G. (1969) Summary Report: District Project No. AT
               69-16.  (Unpublished study received Dec 22, 1969 under 359-626;
               prepared in cooperation with North Carolina State Univ., Dept.
               of Entomology, submitted by Rhone-Poulenc, Inc., Monmouth Junc-
               tion, N.J.; CDL:003174-R)

000006939   Knobel, H.; Rock, G. (1969) Summary Report: District Project No. AT
               69-17.  (Unpublished study received Dec 22, 1969 under 359-626;
               prepared in cooperation with North Carolina State Univ., Dept.
               of Entomology, submitted by Rhone-Poulenc, Inc., Monmouth Junc-
               tion, N.J.; CDL:003174-S)

005014688   Kovaleva, E.S.; Talanov, G.A. (1977) Absorptsiya TKhM-3 i fozalona
               iz pochvy i ikh migratsiya v rasteniya.   [Trichlorometaphos-3
               and phosalone absorption from the soil and their migration  into
               plants.]  Gigiena i Sanitariya.   [Hygiene and Sanitation.]
               42(12):87-88.

000006067   Laurent, ?; Buys, ?; Aublet, ?; Bottreau, ?  (1975) Phosalone:
               Solubility and Stability in Water: R.P./R.D./C.N.G.—An
               No. 2793.   (English translation; unpublished study received Sep
               29, 1975 under 359-620; prepared by Societe des Usines Chimiques
               Rhone-Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth
               Junction, N.J.; CDL:094857-A)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006645   Laurent, M. (1964) Methods of Identification and Estimation of
               Phosalone.  Three methods dated Oct 7, 1963.  (English transla-
               tion; unpublished study received 1965 under 359-EX-46; prepared
               by Societe des Usines Chimiques Rhone-Poulenc,  submitted by
               Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:123396-F)

000006700   Laurent, M.; Aublet, J.C.; Sasmayoux, J.C.  (1967)  Phosalone:  Method
               of Determination of Phosalone Residues in Plants by Gas-Liquid
               Chromatography: R.P.—D.S.Ph. No. 11791.  Method dated Feb 3,
               1967.   (Unpublished study received Jun 14, 1968 under 8F0668;
               prepared by Societe des Usines Chimiques Rhone-Poulenc, sub-
               mitted by Chipman Chemical Co., Inc., Burlingame, Calif.;  CDL:
               091171-A)

000006665   Laurent, M.; Buys, M.; Chabassol, Y.; Sauli, M.; Brunie, B. ;  Ray-
               naud, L.; DePaire, H.; Snozzi, C.; Kretz, M.; Bisch, D.  (1977)
               Phosalone (11974 R.P.): Photodegradation in the Water-Dissolved
               State: R.P./R.D./C.N.G.-An—Report No. 3131.  (Unpublished study
               received May 10, 1977 under 359-620; prepared by Societe des
               Usines Chimiques Rhone-Poulenc, submitted by Rhone-Poulenc,
               Inc., Monmouth Junction, N.J.; CDL:229759-E)

000006708   Laurent, M.; Buys, M.; Sasmayoux, J.C.  (1968) Phosalone: G.L.C. De-
               termination of Phosalone and 12244 R.P.  in Apples and in Grape
               Extracts from the U.S.A.: D.S.Ph./D.S.An.Nord No. 12864.   (Un-
               published study received Jun 14, 1968 under 8F0668; prepared by
               Societe des Usines Chimiques Rhone-Poulenc, submitted by Chip-
               man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-J)

000006698   Laurent, M.; Terlain, B.; Vertalier, S.  (1965) Phosalone
               (RP 11974): Stability of the Bulk Product;  (Control 64-R-1921):
               R.P.—D.S.An. Nord—No. 151.  Includes two methods dated Dec 3,
               1964.   (English translation; unpublished study  received Dec 15,
               1966 under 7G0575; prepared by Societe des Usines Chimiques
               Rhone-Poulenc, submitted by Chipman Chemical Co., Inc., Bur-
               lingame, Calif.; CDL:090729-N)

005007745   Leffingwell, J.T.; Spear, R.C.; Jenkins, D.  (1975) The persistence
               of ethion and Zolone residues on grape foliage  in the Central
               Valley of California.  Archives of Environmental Contamination
               and Toxicology 3(1):40-54.

005007744   Leffingwell, J.T.; Turner, E.R.; Futagaki,  S.; Spear, R.C.  (1977)
               A field survey of dislodgeable Zolone residues  in twelve
               commercially treated vineyards.  Bulletin of Environmental
               Contamination and Toxicology  18(2):219-226.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006430   Lillie, D.T. (1972) Final Report: District Project No. F 72-57.
               (Unpublished study received Mar 16, 1973 under 359-620; prepared
               by Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Momnouth
               Junction, N.J.; CDL:008914-B)

000006747   Lillie, D.T.; Carman, G. (1971) Final Report: District Project
               No. FD 71-91.   (Unpublished study received on unknown date under
               2F1193; prepared in cooperation with Univ. of California—River-
               side, submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:
               093518-G)

000006748   Lillie, D.T.; Carman, G. (1971) Final Report: District Project
               No. FD 71-92.   (Unpublished study received on unknown date under
               2F1193; prepared by Univ. of California—Riverside, submitted by
               Rhodia, Inc., New Brunswick, N.J.; CDL:093518-H)

005001833   Maddy, K.T. (1976) Current considerations on the relative
               importance of conducting additional studies on hazards of field
               worker exposure to pesticide residues as compared to studying
               other occupational safety hazards on the farm.  Pages 125-
               142,@In@Pesticide Residue Hazards to Farm Workers—Proceedings
               of a Workshop; Feb 9-10, 1976, Salt Lake City, Utah.
               Washington, D.C.:  U.S. Government Printing Office.   (HEW
               publication no.  (NIOSH) 76-191)

005011351   Makarova, S.V.; Bel'skaya, G.; Soboleva, D.A.  (1972) Analiz
               ftalofosa i benzofosfata iodometricheskim metodom.   [Analysis
               of phthalophos  and benzophosphate by an iodometric titration
               method.]  Khimiya v Sel'skom Khozyaistve.   [Chemistry in
               Agriculture.] 10(5):361-362.

000006976   McGinnis, C.H., Jr.  (1974) The Effect of Dietary Phosalone on Body
               Weight, Feed Consumption, Reproduction and the Production of
               Phosalone Residues in Body Tissues and Eggs of Single Comb White
               Leghorn Chickens: Research Report No. CHM 74:121.   (Unpublished
               study received  Mar 4, 1976 under 6F1753; submitted by Rhodia,
               Inc., Monmouth Junction, N.J.; CDL:098088-Q)
005016356   Nalbandyan, R.A.  (1975) 0 vozmozhnosti proniknoveniya  nekotorykh
               pestitsidov v yagody vinograda.   [The possibility of
               penetration of some pesticides  into grapes.]   Vinodelie i
               Vinogradarstvo SSSR.   [Winemaking  and Viticulture in  the USSR.
               (6):42-43.

005005773   Nelson, E.E.; Croft, B.A.; Howitt, A.J.; Jones,  A.L.  (1973)
               Toxicity of apple orchard pesticides to Agistemus fleschneri.
               Environmental Entomology 2(2):219-222.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base  Supporting
                        Registrations Under the Standard

000006111   Noel, P.R.B.; Rivett, K.F.; Osborne, B.E.; Street, A.E.  (1970)
               Phosalone: Dietary Intake in Beagle Dogs for  Four Weeks: Report
               No. 3619/70/431.   (Unpublished study received Mar 4,  1976 under
               6F1753; prepared by Huntingdon Research Centre for May &
               Baker, Ltd., submitted by Rhodia, Inc., Monmouth Junction,
               N.J.; CDL:095979-M)

000006110   Pasquet, J.; Buisson, M.  (1969) Etude de L'Activite Teratogene de
               la Phosalone  (11974 R.P.) sur L'Embryon de  Poulet et  sur la
               Lapine: R.P.—D.S.Ph. No. 13447.   [Study of Teratological Acti-
               vity of Phosalone  (RP 11974) on Chicken Embryos and Rabbits.]
               (Unpublished study including English translation, received Mar
               4, 1976 under 6F1753; prepared by Societe des Usines  Chimiques
               Rhone-Poulenc, submitted by Rhodia, Inc., Monmouth Junction,
               N.J.; CDL:095979-L)

005007746   Pasquet, J.; Mazuret, A.; Fournel, J.; Koenig, F.H.  (1976) Acute
               oral and percutaneous toxicity of phosalone in the rat, in
               comparison with azinphosmethyl and parathion. Toxicology and
               Applied Pharmacology 37(1):85-92.

005005243   Popendorf, W.J.; Spear, R.C.; Leffingwell, J.T.; Yager,  J.; Kahn,
               E.  (1979) Harvester exposure to Zolone  (phosalone) residues  in
               peach orchards.  Journal of Occupational Medicine
               21(3):189-194.

000006792   Posner, S. (1971) Cow-Feeding Study with Phosalone  (Technical)
               Insecticide  (Dairy Cattle)—Biological Phase.  (Unpublished
               study including letter dated Jul 26, 1971 from L.C. Brown to
               Lee E. TerBush, received Jun 13, 1974 under 359-620;  prepared by
               Biometric Testing, Inc. for Rhodia, Inc., submitted by Rhone-
               Poulenc, Inc., Monmouth Junction, N.J.; CDL:120351-T)

000006761   Posner, S. (1971) Cow-Feeding Study with Phosalone  (Technical)
               Insecticide  (Dairy Cattle)—Biological Phase.  (Unpublished
               study including project no. 49-181, received  Jun  26,  1972 under
               OF0983; prepared in cooperation with Biometric Testing,  Inc.,
               submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:091691-C)

000006479   Preiser, F.A.; Taschenberg, E.F.  (1968) Report No. BB 68-91.   (Un-
               published study received Nov 18, 1971 under 359-626;  prepared
               in cooperation with Cornell Univ., submitted  by Rhone-Poulenc,
               Inc., Monmouth Junction, N.J.; CDL:003175-T)

GS0027025   Rhodia, Incorporated, Chipman Division (?)  [Dates of application
               and graphs of residue data for apricots, cherries, nectarines,
               peaches, and plums/prunes.]  (Unpublished study received ? under
               1F1155)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006120   Rhodia, Incorporated (19??) Phosalone in Dairy Cattle Tissue:  Sum-
               mary.  (Unpublished study received May 6, 1970 under  OF0983;
               CDL:093292-G)

000006113   Rhodia, Incorporated (19??) Technical Data Bulletin: Zolone:  In-
               secticide annd Miticide. (Unpublished study received  Mar 4, 1976
               under 6F1753; CDL:095979-O)

000006651   Rhodia, Incorporated (19??) Technical Data Sheet—Zolone: Insecti-
               cide and Miticide.  (Unpublished study received Mar 4, 1974 un-
               der 359-EX-52; submitted by Rhone-Poulenc, Inc., Monmouth Junc-
               tion, N.J.; CDL:123398-A)

000006712   Rhodia, Incorporation  (1967) Field and Analytical Data:  Phosalone
              Residues in Apples—Ontario, Canada—1967.  (Unpublished  study
              received Jun 14, 1968 under 8F0668; submitted by Chipman  CHemical
              Co., Inc., Burlingame, Calif.; CDL:091171-x)

000006717   Rhodia, Incorporated (1967) Phosalone Feeding Test.   (Unpublished
               study received Jun 14, 1968 under 8F0668; prepared in coopera-
               tion with Woodard Research Corp., submitted by Chipman Chemical
               Co., Inc., Burlingame, Calif.; CDL:091171-AM)

000006123   Rhodia, Incorporated (1967) Summary: Analysis of Phosalone  (RP
               11974) Residue in Tissues of Beef Cattle and Sheep.   (Unpub-
               lished study received May 6, 1970 under OF0983; CDL:093292-J)

000006210   Rhodia, Incorporated (1971) Phosalone—Tea: Phosalone Residue Stud-
               ies.  (Unpublished study including letters dated Jul  19,  1972
               from J. Metivier and P. Petrinko to Tea Research Association and
               Aug 1, 1972 from B. Banerjec to Societe des Usines Chimiques
               Rhone-Poulenc, received Jun 8, 1973 under 3H5038; prepared in
               cooperation with Tea Research Association and United  Planters
               Association of Southern India; CDL:221773-B)

000006357   Rhodia, Incorporated (1972?) Phosalone Dried Apple Pomace Data.
               Includes undated method.  (Unpublished study received Jun 26,
               1972 under OF0983; prepared in cooperation with Cornell  Univ.,
               New York State Agricultural Experiment Station, Dept. of Food
               Science and Technology; CDL:091691-A)

000006733   Rhodia, Incorporated (1972) Effect of Zolone EC on Stone Fruits;
               Phytotoxicity: Part 1.   (Unpublished study including  district
               project nos. F 72-62, F 72-63, Port 72-27, Port 72-32 and Port
               72-41, received Mar 16, 1973 under 359-620; submitted by Rhone-
               Poulenc,  Inc., Monmouth Junction, N.J.; CDL:096444-A)

000006172   Rhone-Poulenc, Incorporated  (1966) Chemical and Physical Proper-
               ties:  [Phosalone].  (Unpublished study received Jul  7,  1966
               under unknown admin, no.; CDL:127090-A)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the  Data  Base  Supporting
                        Registrations Under the Standard

GS0027021   Rhone-Poulenc, Incorporated  (1980) Lifetime Oncogenicity Study in
               Mice.   (Unpublished study received  Dec 4, 1980  under 6F1753;
               submitted by Rhone-Poulenc, Inc., Monmouth  Junction,  NJ;
               CDL:099788)

000006697   Rivett, K.F.; Davies, V.  (1966) Insecticides:  Effect of Antidotes
               against Poisoning by Phosalone: R.P.—D.S.Ph.—No.  11412.   (Un-
               published study received Dec 15, 1966 under 7G0575;  prepared  by
               May & Baker, Ltd. for  Societe des Usines Chimiques  Rhone-
               Poulenc, submitted by  Chipman Chemical Co., Inc., Burlingame,
               Calif.; CDL:090729-M)

005017962   Sauli, M., inventor; Rhone-Poulenc S.A., assignee  (1975) Verfahren
               zur Herstellung von
               3-0,O-Diaethyldithiophosphorylmethyl-6-chlorbenzoxazolon.
               3-O,O-diethyldithiophosphorylmethyl-6-chloro-benzoxazolone.]
               German  (Fed. Rep.) offenlegungsschrift 24 31  192.   Jan 16.   5
               p. Int. C1.2 C 07F 9-65.

000006688   Scott, W.J.; Bellies, R.P.  (1965) Acute Oral Toxicity  of a Phosa-
               lone  (R.P. 11974) Formulation to Rats.   (Unpublished study  re-
               ceived  Dec 15, 1966 under 7G0575; prepared  by ftfcodard Research
               Corp.,  submitted by Chipman Chemical Co., Inc.,  Burlingame,
               Calif.; CDL:090729-B)

000006794   Scott, W.J.; Bellies, R.P.  (1965) Phosalone: Potentiation Studies
               in the Rat with Marketed  Pesticides.  (Unpublised study received
               Dec 15,  1966 under 7G0575; prepared  by Woodard Research Corp.,
               submitted by Chipman Chemical Co., Inc.,  Burlingame,  Calif.;
               CDL:090729-1)

000006243   Smyth, E.P.; Burkhart, D. ; McCollister, E.G.  (1969) Final Report:
               District Project No. Port 69-19.   (Unpublished  study received
               Mar 26, 1971 under 1F1155; submitted by  Rhodia,  Inc., New Bruns-
               wick, N.J.; CDL:093474-L)

000006639   Smyth, E.P.; Hoyt, S.  (1969) Summary Report: District  Project
               No. Port 69-40.   (Unpublished study received  Dec 22, 1969 under
               359-626; submitted by  Rhone-Poulenc,  Inc.,  Monmouth Junction,
               N.J.; CDL:003174-Q)

000006793   Smyth, E.P.; Johansen, C.  (19??) Report No. Port 68-67.  (Unpub-
               lished  study received  Jun 13, 1974  under 359-620; prepared  in
               cooperation with Washington State Univ., submitted  by Rhone-
               Poulenc, Inc., Monmouth  Junction, N.J.;  CDL:120351-X)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006283   Smyth, E.P.; Jones, S.C. (1970) Final Report: District Project
               No. Port 70-22.  (Unpublished study received Mar 26, 1971 under
               1F1155; prepared in cooperation with Oregon State Univ., Ento-
               mology Dept., submitted by Rhodia, Inc., New Brunswick, N.J.;
               CDL:093474-BD)

000006943   Societe des Usines Chimiques Rhone-Poulenc (19??)  [Infra-Red Spec-
               trum and Ultra-Violet Spectrum of Phosalone].   (Unpublished
               study received 1965 under 359-EX-46; submitted by Rhone-Poulenc,
               Inc., Monmouth Junction, N.J.; CDL:123396-C)

000006398   Societe des Usines Chimiques Rhone-Poulenc (1966) Phosalone: Chro-
               ma tog raphical Analysis: R.P.—D.S.Ph. No. 11345.  (Unpublished
               study received Feb 2, 1967 under 7G0575; submitted by Chipman
               Chemical Co., Inc., Burlingame, Calif.; CDL:090727-S)

000006701   Societe des Usines Chimiques Rhone-Poulenc (1968) Phosalone: Iden-
               tification of Phosalone in Plant Extracts: R.P.—
               D.S.Ph. No. 12642.  Includes two methods dated Feb 20, 1968.
               (Unpublished study including R.P.—D.S.Ph. No. 13021, received
               Jun 14, 1968 under 8F0668; submitted by Chipman Chemical Co.,
               Inc., Burlingame, Calif.; CDL:091171-B)

000006674   Societe des Usines Chimiques Rhone-Poulenc (1968) 12244 R.P.:
               Oxygen Analog of Phosalone: Acute Oral Toxicity and Anticho-
               linesterasic Activity in Vitro: R.P.—D.S.Ph. No. 12644.  (Un-
               published study received Jun 14, 1968 under 8F0668; submitted by
               Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:091170-B)

000006675   Societe des Usines Chimiques Rhone-Poulenc (1968) 20650 R.P.: The
               Final Metabolite of Phosalone in Plants: Synthesis, Identifica-
               tion, Toxicity, Possible Presence in Plants: R.P.—
               D.S.Ph. No. 12645.  Includes method dated Feb 20, 1968.  (Unpub-
               lished study received Jun 14, 1968 under 8F0668; submitted by
               Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:091170-C)

GS0028009   Societe des Usines Chimiques Rhone-Poulenc (1973)  Phosalone:
               Chromatography Test:  Identification of Impurities.  A
               translation of:  Examen Chromatographique Identification des
               Impuretes.  [S.U.C.R.P.-Document D.S. An. Nord No. 2340;
               Petition No. 6F1753]

000006738   Spencer, W.T.; Hofmaster, R.N.  (1974) Final Report: District
               Project No. 314574-011.   (Unpublished study received May 10,
               1977 under 359-620; prepared by Rhodia, Inc.  in cooperation
               with Virginia Truck and Ornamentals Research  Station, submitted
               by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:229758-AY)

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                          OFFICE OF  PESTICIDE  PROGRAMS
                       REGISTRATION  STANDARD BIBLIOGRAPHY
           Citations Considered to be  Part  of  the  Data  Base Supporting
                        Registrations  Under the  Standard

000006593   Szabo, J.; Sleesman, J.P.  (1971) Zolone  EC—Potatoes:  Final Report
               No. CH 71-103.   (Unpublished study  received  Dec  7,  1972 under
               3F1337; prepared in cooperation with  Ohio  State  Univ.,  Dept.  of
               Entomology, submitted by  Rhodia,  Inc., New Brunswick, N.J.;
               CDL:094849-E)

000006592   Szabo, J.; Wells, A.  (1971)  Zolone EC—Potatoes:  Final Report
               No. CH 71-61.   (Unpublished  study received Dec 7,  1972  under
               3F1337; prepared in cooperation with  Michigan State Univ., sub-
               mitted by Rhodia, Inc., New  Brunswick, N.J.; CDL:094849-D)

000006073   Totman, L.C.; Greenstein,  E.T.; Woodard, M.W.;  Woodward, G. (1967)
               Phosalone: Analysis of  Residue  in Milk of  Dairy  Cattle.  (Unpub-
               lished study received Oct 16, 1967  under 9F0759; prepared by
               Woodard Research Corp., submitted by  Rhodia, Inc.,  New  Bruns-
               wick, N.J.; CDL:093071-I)

000006071   Totman, L.C.; Imming, R.J.;  Woodard, G.  (1967)  Phosalone:  Analysis
               of Compound Residue in  Tissues  of Beef Cattle and  Sheep.  (Un-
               published study received  Oct 16,  1967 under  9F0759; prepared  by
               Woodard Research Corp., submitted by  Rhodia, Inc.,  New  Bruns-
               wick, N.J.; CDL:093071-E)

000006668   United States of America Standards Institute  (1967) Common Name  for
               the Pest Control Chemical: 0,O-diethyl S-[(6-chloro-2-oxobenzo-
               xazolin-3-yl)methyl]  phosphorodithioate: Phosalone.  New York:
               USAS.  (USAS K62.67-1967; also  In unpublished submission re-
               ceived Dec 8, 1967 under  8F0668;  submitted by Chipman Chemical
               Co., Inc., Burlingame,  Calif.;  CDL:092961-A)

GS0027006   United States Environmental  Protection Agency (1972)  Pharamcology
               Laboratory Toxicity Report-Screening. I.D.  Number 100837.
               (Unpublished report concerning  the  acute oral toxicity  of Zolone
               EC on rats; prepared  by the  Pharmacology Laboratory, Beltsville,
               MD)

GS0027004   United States Environmental  Protection Agency (1972)  Pharmacology
               Laboratory Toxicity Report-Screening. I.D.  Number 101099.
               [Unpublished report concerning  the  acute oral toxocity  of Zolone
               EC to rats,-prepared by  the Pharmacology  Laboratory, Beltsville,
               MD]

GS0027005   United States Environmental  Protection Agency (1973)   Pharmacology
               Laboratory Toxicity Report-Screening. I.D.  Number
               91855.(Unpublished report concerning  the acute oral toxicity  of
               Zolone WP on rats; prepared  by  the  Pharmacology  Laboratory,
               Beltsville,MD]

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GS0027003
               OFFICE OF PESTICIDE PROGRAMS
            REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
             Registrations Under the Standard

 United States Environmental Protection Agency  (1976) Report of
    Analysis.  Sample Number 120574.   [Unpublished report
    concerning the acute oral toxicity of Zolone WP on  rats;
    prepared by the Pharmacology Laboratory, Beltsville, MD]
000006289   Wang, D.  (1970) Final Report: District  Project No.  PAW 70-20 and
               20A.   (Unpublished study received Mar  26,  1971 under 1F1155;
               submitted by Rhcdia,  Inc., New Brunswick,  N.J.;  CDL:093474-BM)

000006477   Wang, D.  (1970) Final Report: District  Project No.  PAW 70-29.
               (Unpublished study received Nov  18,  1971 under 359-626;  prepared
               by Rhodia, Inc., submitted by Rhone-Poulenc,  Inc.,  Monmouth
               Junction, N.J.; CDL:003175-N)

000006114   Wang, D.  (1970) Summary  Report: District  Project No.  PAW 70-4c.
               (Unpublished study received Sep  2, 1970 under OF0983; submitted
               by Rhodia, Inc., New  Brunswick,  N.J.;  CDL:091693-C)

000006115   Wang, D.  (1970) Summary  Report: District  Project No.  PAW 70-42.
               (Unpublished study received Sep  2, 1970 under OF0983; submitted
               by Rhodia, Inc., New  Brunswick,  N.J.;  CDL:091693-D)

000006145   Wang, D.  (1972) Final Report: District  Project No.  FW 72-25.   (Un-
               published study received Mar 16, 1973  under 359-620; prepared by
               Rhodia,  Inc.,  submitted by Rhone-Poulenc,  Inc.,  Monmouth Junc-
               tion,  N.J.; CDL:009830-C)

005013359   Watve, C.M.; Lienk, S.E.  (1975) Responses of  two phytoseiid mites
               to pesticides  used in New York apple orchards.   Environmental
               Entomology 4(5):797-800.

005014275   Watve, C.M.; Lienk, S.E.  (1976) Toxicity  of carbaryl  and six
               organophosphorus insecticides to Arnblyseius
               fallacis and Typhlodromus pyri from  New York apple orchards.
               Environmental  Entomology 5(2):368-370.

005001343   Winterlin,  W.; Kilgore,  W. ; Mourer, C. ; Mull, R.; Walker, G. ;
               Knaak, J.; Maddy, K.  (1978) Dislodgable residues of dialifor
               and phosalone  and their oxygen analogs following a reported
               worker-injury  incident in the San Joaquin  Valley,  California.
               Bulletin of Environmental Contamination and Toxicology
               20(2):255-260.

005009309   Winterlin,  W.; Mourer, C.; Bailey,  J.B. (1974) Degradation of four
               organophosphate insecticides  in  grape  tissues.   Pesticides
               Monitoring Journal 8(1):59-65.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                        Registrations Under the Standard

000006695   Woodard, M.W. ; Cockrell, K.O.; Woodard, G. (1966) Phosalone: Demye-
               lination Study in Chickens.  (Unpublished study received Dec  15,
               1966 under 7G0575; prepared by Woodard Research Corp., submitted
               by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090729-K)

000006202   Woodard, M.W.; Howard, D.J.; Donsos, J.; Woodard, G.  (1967)
               Phosalone: Safety Evaluation by Repeated Oral Administration  to
               Rats for 103-104 Weeks.  (Unpublishedstudy received Oct 17, 1967
               under 7G0575; prepared by Woodard Research Corp.,  submitted by
               Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090730-A)

000006677   Woodard, M.W.; Imming, R.J.; Thompson W.: Woodard, G. (1967)
               Phosalone: Safety Evaluation by Oral Administration to Calves
               for Ten Weeks.  (Unpublished study received Jun 14, 1968 under
               8F0668; prepared by Woodard Research Corp., submitted by Chipman
               Chemical Co, Inc., Burlingame, Calif.; CDL:091170-E)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005012117   Abdel-Salam, A.M.; Kaiery, E.; Abbasy, A.M.; Assem, M.A.  (1972)
               Effects of granular insecticides on some pests of horse bean
               and peas as well as on plant growth and root nodulation.
               Zeitschrift fuer Angewandte Entomologie 70(4):408-413.

005013142   Abelentseva, G.M.; Sedykh, A.S. (1973) Fitotsidnost1 insektitsidov
               dlya vskhodov pshenitsy.  [The phytocidal activity of
               insecticides toward wheat shoots.]  Khimiya v Sel'skom
               Khozyaistve.  [Chemistry in Agriculture.] 11(10):756-757.

005003855   Adams, R.G.; Prokopy, R.J. (1977) The ecology of the aphid
               predator, Aphidoletes aphidimyza (Cecidomyiidae: Diptera), and
               the effect of pesticides on its survival in apple orchards.
               Journal of the New York Entomological Society LXXXV(4):163.

005016357   Adeishvili, L.; Mamaladze, L. (1976) Pospororganuli pestitsidebis
               dashlis khangrdzlioba kurkovani khekhilis potolsa da nakopshi.
               in the leaves and fruit of pomaceous fruit trees.]  Trudy
               Institute Zashchity Rastenii, Tiflis.   [Transactions of the
               Institute of Plant Protection.] XXVIII:96-98.

005017295   Adeishvili, L.D.; Klisenko, M.A.; Pis'mennaya, M.V. (1976)
               Dinamika umen'sheniya ostatkov pestitsidov v plodakh.   [Rate of
               pesticide residue reduction in fruits.]  Khimiya v Sel'skom
               Khozyaistve.   [Chemistry in Agriculture.] 14(11):43-44.

000006491   Alabaster, J.S.  (1969) Survival of fish in 164 herbicides, insecti-
               cides, fungicides, wetting agents and miscellaneous substances.
               International Pest Control (Mar/Apr):29-35.  (Also Iri  un-
               published submission received Jun 13, 1974 under 359-620;  sub-
               mitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:
               120351-L)

005013141   Aleksidze, G.N.  (1969) Vliyaniya yadokhimikatov na koktsinellidy.
               Sadovodstvo Vinogradarstvo i Vinodelie Moldavii.
               24(4):47-48.

005015605   Aleksidze, G.N.  (1971) Gardabnis raionis khekhilis bagebshi
               gavrtselebuli koktsinelidebis sakheobata gamovlinebis  da
               skhvadaskhva preparatis matze mokmedebis shestsavlis shedegebi.

-------
                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005001130
005014555
005008184
005009830
000006655
000006490
005008183


005013289
Allen, P.G. (1971) Effects of some organic phosphorus and
   endosulfan seed dressings on wheat.  Australian Journal of
   Experimental Agriculture and Animal Husbandry 11(52):556-558.

Altay, M.; Gurkan, S.  (1972) Effects of agricultural chemicals
   applied to vines during flowering stage, on pollination of
   varions of export grape varietis.  Pages 176-177, _In Zirai
   Mucadele Arastirma Yilligi.   [Plant Protection Research
   Annual.]  Ankara, Turkey:  Bolge Zirai Mucadele Arastirma
   Enstitusu.

Ambrosi, D.; Helling, C.S. (1977) Leaching of oxadiazon and
   phosalone in soils.  Journal of Agricultural and Food Chemistry
   25(1):215-217.

Ambrosi, D.; Kearney, P.C.; Macchia, J.A.  (1976) Persistence and
   metabolism of phosalone in soil.  Abstracts of Papers of the
   American Chemical Society 172:106.

Anderson, L.D.; Atkins, E.L., Jr.  (1967) Toxicity of Pesticides and
   Other Agricultural Chemicals to Honey Bees: Field Study.  By
   Univ. of California, Dept. of Entomology.   Riverside, Calif.:
   U.C.  (Agricultural Extension Service AXT-251; also In_ unpub-
   lished submission received Nov 17, 1975 under 359-620; submitted
   by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:223344-E)

Anderson, L.D.; Atkins, E.L., Jr.; Nakakihara, H.; Greywood, E.A.
   (1971) Toxicity of Pesticides and Other Agricultural Chemicals
   to Honey Bees: Field Study.  Rev.   Riverside, Calif.: Univ. of
   Calif., Agricultural Extension.  (AXT-251; also In unpublished
   submission received Jun 13, 1974 under  359-620; "submitted by
   Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:120351-1)
Anon. (1973) Coming: worker re-entry regulations.
   136(2):54,56.
Farm Chemicals
Antonovich, E.A.; Vekshtein, M.S.  (1975) Vliyanie razlichnykh
   vidov perera'otki produktov pitaniya na soderzhanie
   ostatochnykh kolichestv fosfororganicheskikh pestitsidov.   [The
   effects of different ways of processing food produce on  their
   content of organophosphorus pesticide residues.]  Voprosy
   Pitaniya.   [Problems of Nutrition.]  (6):75-78.

-------
                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005015386   Aoki, Y.; Takeda, M.; Uchiyama, M. (1976) Shokuhinchu no
               zanryunoyaku no bunseki ni kansuru kenkyn (dai 18-ho)
               gasukuromatoguratogurafi ni yoru yukirinnoyaku no
               keitobunsekiho narabi ni yukirinhoyaku no enkokodokeikenshukki
               ni taisuru kando ni oyobosu suiso oyobi kukirynsoku no eikyo.
               Systematic analysis of organophosphorus pesticides by gas
               chromatography and influence of the flow rate of hydrogen and
               air on their response to flame photometric detector.]  Eisei
               Kagaku.  [Journal of Hygienic Chemistry.] 22(2):81-90.

005013143   Arutyunova, E.V. (1977) Vliyanie antio i fozalona na razvitie
               yabloni.  [The effect of antio and phosalone on the development
               of apple trees.]  Khimiya v Sel'skom Khozyaistve.  [Chemistry
               in Agriculture.] 15(3):45-46.

005007035   Arzone, A. (1975) Indagini e proposte su antiparassitari
               presentati come non dannosi all'entomofauna utile.
               harmless to useful insects.]  Apicoltore Moderno 66(1):16-25.

005010424   Askew, J.; Ruzicka, J.H.; Wheals, B.B. (1968) Use of hydriodic
               acid in the detection of pesticides after thin-layer
               chromatography.  Journal of Chromatography 37(2):369-372.

000009033   Asquith, D.; Colburn, R. (1973) 1973 Laboratory Evaluation of Vari-
               ous Pesticides on Stethorus punctum Adults.   (Unpublished study
               received Mar 13, 1978 under CO 78/5; prepared by Pennsylvania
               State Univ., Fruit Research Laboratory, submitted by E.I. du
               Pont de Nemours & Co., Wilmington, Del.; CDL:236817-F)

005001682   'Asquith, D.; Hull, L.A.  (1973)  Stethorus punctum and
               pest-population responses to pesticide treatments on apple
               trees.  Journal of Economic Entomology 66(5):1197-1203.

005013145   Babii, V.S.; Tsvetkova, A.G. (1972)  Reaktsiya yabloni na raznye
               kontsentratsii pestitsidov pri maloob'emnom opryskivanii.   [The
               reaction of apple trees to different pesticide concentrations
               in low volume spraying.]  Khimiya v Sel'skom Khozyaistve.

005012841   Bailey, J.B. (1972) The effects of pesticide residues on farm
               laborers.  Agrichemical Age 15(10):6-8,10.

000006691   Bellies, R.P.; Knott, W.; Scott, W.J. (1965) Safety Evaluation of
               Phosalone (R.P. 11974) in Fish and Wildlife (Bobwhite Quail,
               Mallard Ducks, Rainbow Trout, Bluegill Sunfish, Goldfish and
               Oysters).  (Unpublished study received Dec 15, 1966 under
               7G0575; prepared by Woodard Research Corp., submitted by Chipman
               Chemical Co., Inc., Burlingame, Calif.; CDL:090729-F)

-------
                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
005015128   Berim, N.G.; Bykhovets, A.I.  (1973) Izraenenie gazoobmena
               cheshuekrylych nasekomykh pri kohtaktnom otravlenii sevinom,
               ftalofosom i fozalonon.   [Change in gas metabolism of
               Lepidoptera during contact poisoning by Sevin, phthalophos, and
               phosalone.]  Zapiski Leningradskogo Sel'skokhozyaistvennogo
               Instituta.   [Reports of the Leningrad Agricultural Institute.]
               212:38-41.
005016358   Biro, L.; Nagy, B.  (1974) Fozalon meghatarozasa spektrofotometriai
               modszerekkel.   [Determination of phosalone by
               spectrophotometric methods.]  Nehezvegyipari Kutato Intezet
               Kozlemenyei.   [Communications of the Research Institute for
               Heavy Chemical  Industry.] 5:127-133.

005013734   Blagonravova, L.N.; Karakhanova, S.V.  (1974) Vliyanie pestitsidov
               na biokhimicheskie protsessy v yablokakh vo vremya
               osenne-zimngo khraneniya.   [Effect of pesticides on biochemical
               processes in apples during autumn-winter storage.]  Khimiya v
               Sel'skom Khozyaistve.   [Chemistry in Agriculture.]
               12(3):202-204.

005013733   Blagonravova, L.N.; Karakhanova, S.V.; Kriventsov, V.I.  (1974)
               Vliyanie khimicheskikh preparatov, primenyaemykh v period
               vegetatsii yabloni, na kachestvo yablok vo vremya
               osenne-zimnego  khraneniya.   [Effect of chemical preparations
               used during the vegetation period of an apple tree on the
               quality of apples during autumn-winter storage.]  Khimiya v
               Sel'skom Khozyaistve.   [Chemistry in Agriculture.]
               12(6):442-444.

005006362   Bournoville, R.; Tasei, J.N. (1977) Effets compares de quelques
               insecticides sur les mirides nuisibles a la luzerne,  leurs
               predateurs et les apoides pollinisateurs.   [Comparative effects
               of some insecticides against harmful mirids of alfalfa, their
               predators and the pollinating apoids.]
               Phytiatrie-Phytopharmacie 26(3):185-192.

005001037   Bowman, M.C.; Beroza, M.  (1970) GLC retention  times of pesticides
               and metabolites containing phosphorus and sulfur on four
               thermally stable columns.  Journal  of the Association of
               Official Analytical Chemists 53(3):499-508.

005018185   Buchner, R.O.  (1973) Bienenvergiftungen durch  Rebschutzmassnahmen
               und ihre Verhuetung.   [Bee poisoning caused by measures to
               protect vines and its prevention.]  Tieraerztliche Umschau
               28(12):623-625.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
000006760   Burr, R.; Baird, C. (1975) Final Report: District Project
               No. 351175-065.  (Unpublished study received Mar 24, 1976 under
               359-620; prepared by Rhodia, Inc. in cooperation with Univ. of
               Idaho, Extension, submitted by Rhone-Poulenc, Inc., Monmouth
               Junction, N.J.; CDL:095197-BJ)

000006352   Burr, R.; Burr, J. (1975) Final Report: District Project
               No. 353675-060.  (Unpublished study received Mar 24, 1976 under
               359-620; prepared by Rhodia, Inc. in cooperation with Oregon
               State Univ., Extension Service, submitted by Rhone-Poulenc,
               Inc.., Monmouth Junction, N.J.; CDL:095197-BI)

000006696   Celice, J.; Fournel, J. (1966) Evaluation of Risks of Intoxication
               by Phosalone  (11974 R.P.) during Its Manufacture and Its Experi-
               mentation in the Field: R.P.—D.S.Ph. No. 11346.   (Unpublished
               study received Dec 15, 1966 under 7G0575; prepared by Societe
               des Usines Chimiques Rhone-Poulenc, submitted by Chipman Chemi-
               cal Co., Inc., Burlingame, Calif.; CDL:090729-L)

005018286   Chakrabarti, J.; Roy, B.R.; Mojumder, K.K.  (1979) Pesticidal
               action and stability of phosalone in dry fish.  Journal of Food
               Sc ience and Technology (Mysore) 16(1):3 5.

005007529   Chepurnaya, V.I. (1975) Fitotsidnost1 nekotorykh pestitsidov dlya
               persika.   [Phytocidal activity of certain pesticides for
               peaches.]  Khimiya v Sel'skom Khozyaistve.  [Chemistry in
               Agriculture.] 13(1):34-36.

000011464   Cherry, E.T.  (1977) Biological Research Report on Insecticide Ef-
               ficacy and Crop Safety: Supracide 2E for Insect Control on Arti-
               chokes: R&D Objective: 303018.  Summary of studies 096254-B
               through 096254-D, 096254-F, 096254-H through 096254-K, 096254-M
               and 096254-N.  (Unpublished study received Jul 19, 1977 under
               100-501; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
               096254-A)

005016118   Chevrel, J. (1964) Un nouvel insecticide polyvalent: la phosalone.
               Vegetaux 18(106):6-11.

005016026   Chikov, V.I.; Bulka, M.Y.; Lozovaya, V.V. (1972) Vliyanie
               insektitsidov na raspredeleniye C-14 v produktakh fotosinteza.
               photosynthesis products.]  Fiziologiya Rastenii.   [Plant
               Physiology.] 19(1):190-193.

005015135   Chikov, V.I.; Lozovaya, V.V. (1973) Vliyanie insektitsidov na
               postfotosinteticheskii metabolizm C14-assimilyatov v list'yakh
               bobov.   [The effect of insecticides on the post-photosynthetic
               metabolism of 14C-labelled assimilates in broad bean leaves.]
               Fiziologiya Rastenii.  [Plant Physiology.] 20(2):317-320.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
005001452   Chiou, C.T.; Freed, V.H.; Schmedding, D.W.; Kohnert, R.L.  (1977)
               Partition coefficient and bioaccumulation of selected organic
               chemicals.  Environmental Science and Technology 11(5):475-478.

000006401   Chipman Chemical Company, Incorporated  (19??) The Name, Chemical
               Identity, and Composition of the Pesticide Chemical:  [Phosa-
               lone].  (Unpublished study received Mar 6, 1967 under 7G0575;
               CDL:092863-C)

000006993   Chipman Chemical Company, Incorporated  (1964) Chipman Products
               Data: Experimental Insecticide R.P.  11974: Technical Data Sheet
               TD/9/64.  (Unpublished study received Apr 17, 1964 under 7G0575;
               prepared in cooperation with Rhone-Poulenc Chemical Co.; CDL:
               090736-CR)

000006387   Chipman Chemical Company, Incorporated  (1966) Results of Tests on
               the Amount of Residue Remaining:  [Phosalone].  (Unpublished
               study received Feb 2, 1967 under 7G0575; CDL:090727-F)

000006661   Chipman Chemical Company, Incorporated  (1967) Safety to Honey Bees:
               Technical Bulletin.  4th ed.  (pp. 5-6 only; unpublished study
               received Nov 17, 1975 under 359-620; submitted by Rhone-Poulenc,
               Inc., Monmouth Junction, N.J.; CDL:223344-O)

000014256   Ciarletta, J.A.; Smith, R.L.; Sleesman, J.; et al. (1975) Moni-
               tor  (R): Efficacy, Phytotoxicity and Yield Effects on Peppers.
               (Unpublished study including report nos. 31525, 31659,  31726,
               31735, 32153, 36254, 36258, 36259, 36337, 36342, 36345, 36346,
               39118, 39140, 39799, 40064, 40729, 40946, 41098, 42715, 42880,
               42916, 43225, 43379 and 44930, received Aug 24, 1978 under 3125-
               280; submitted by Mobay Chemical Corp., Agricultural Div.,
               Kansas City, Mo.; CDL:097315-A)

000006397   Coad, B.R. (1965) Report on an Evaluation of Possible Personal
               Hazard in Aircraft Applications of Zolone on Cotton Fields.
               (Unpublished study received Feb 2, 1967 under 7G0575; prepared
               by Delta Air Lines, Inc., submitted by Chipman Chemical Co.,
               Inc., Burlingame, Calif.; CDL:090727-R)

000006687   Cockrell, K.O.; Woodard, M.W.; Woodard, G.  (1965) Phosalone
               R.P. 11974: Acute Oral LD-50 In Dogs.   (Unpublished study re-
               ceived Dec 15, 1966 under 7G0575; prepared by Woodard Research
               Corp., submitted by Chipman Chemical Co., Inc., Burlingame,
               Calif.; CDL:090729-A)

005004007   Colburn, R.; Asquith, D. (1971) Tolerance of the stages
               of Stethorus punctum to selected  insecticides and miticides.
               Journal of Economic Entomology 64(5):1072-1074.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005008433   Colburn, R.; Asquith, D. (1973) Tolerance of Stethorus
               Economic Entomology 66(4):961-962.

000006978   Collins, R.F.; Roxburgh, J. (1967) Phosalone (11,974 R.P.): Studies
               of Levels in the Skin and Edible Tissues of Sheep: Gas-Liquid-
               Chroma tog raphy (G.L.C.) Determinations: BIOCHEM/353.   (Unpub-
               lished study received Mar 4, 1976 under 6F1753; prepared by May
               & Baker, Ltd., submitted by Rhodia, Inc., Monmouth Junction,
               N.J.; CDL:098088-V)

000006384   Courteix, J.; Desmoras, J.; Laurent, M.; Metivier, J.; Terlain,
               B. (1966) Phosalone: Methods of Analysis and Degradation of
               Residues: R.P.—D.S.Ph. No. 10988.  Includes six methods dated
               Jan 11, 1966.  (Unpublished study received Feb 2, 1967 under
               7G0575; prepared by Societe des Usines Chimiques Rhone-Poulenc,
               submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
               CDL:090727-C)

000006972   Craine, E.M. (1974) Disposition of Phosalone-14C in a Lactating
               Cow: Research Report No. EMC 74:17.   (Unpublished study received
               Mar 4,  1976 under 6F1753; submitted by Rhodia, Inc., Monmouth
               Junction, N.J.; CDL:098088-M)

000006735   Crouch, R.V. (1970) Phosalone  (11974 R.P.): Residue Studies on Tea
               (Green Leaf): Pakistan 1969: Report No. RG/758.  (Unpublished
               study received Jun 8, 1973 under 3H5038; prepared by May &
               Baker, Ltd., submitted by Rhodia, Inc., New Brunswick, N.J.;
               CDL:221773-H)

000006130   Crowley, G.; Smith, M.  (1973) Final Report: District Project
               No. PAS 72-75.  (Unpublished study including letter dated Mar
               15, 1973 from L.C. Brown to P.C. Critchlow, received Mar 16,
               1973 under 359-620; prepared by Rhodia, Inc. in cooperation with
               Texas A & M Univ., submitted by Rhone-Poulenc, Inc., Monmouth
               Junction, N.J.; CDL:009830-A)

000006163   Davis, C.S.; Horn, R.; Van den Bosch, R.; Barnes, M.M.; Sibbett,
               G.S.; Jeter, R.B.; Charles, F.M.  (1972) Impact, reports, obser-
               vations on the Trioxys pallidus.  Diamond Walnut News
               (Feb):8,23.  (Also In unpublished submission received Aug 27,
               1973 under 359-620; submitted by Rhone-Poulenc, Inc., Monmouth
               Junction, N.J.; CDL:026725-P)

000012551   Davis, D.W.  (1967) Alfalfa Weevil Research.  (Incomplete  study; un-
               published study received May 8, 1970  under OF0892; prepared by
               Utah State Univ., submitted by Geigy  Chemical Corp., Ardsley,
               N.Y.; CDL:091543-AC)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate  For Use  in
                           Developing the Standard
000006528   DeLay, D.L. (1968) Report No. PA 68-43.   (Unpublished  study  re-
               ceived Feb 16, 1970 under OF0948; submitted by Rhodia,  Inc.,  New
               Brunswick, N.J.; CDL:092026-H)

000006569   DeLay, D.L. (1969) Summary Report: District Project No.  PA 69-15.
               (Unpublished study received Feb 16,  1970 under OF0948;  submitted
               by Rhodia, Inc., New Brunswick, N.J.;  CDL:092026-BB)

000006534   Delay, D.L. (1969) Summary Report: District Project No.  PA 69-29.
               (Unpublished study received Feb 16,  1970 under OF0948;  submitted
               by Rhodia, Inc., New Brunswick, N.J.;  CDL:092026-Q)

000006237   DeLay, D.L. (1970) Final Report: District Project No.  PA 70-23 &
               23A.   (Unpublished study received Mar  26,  1971 under  1F1155;
               submitted by Rhodia, Inc., New Brunswick,  N.J.; CDL:093474-D)

000006069   Dennis, S.  (1973) Phosalone—Dried Grape  Pomace  Data.  Includes
               undated method.  (Unpublished study  including residue final re-
               port no. 170473-092, received Jul 26,  1974 under 5H5058;  sub-
               mitted by Rhodia, Inc., Somerset, N.J.; CDL:221786-A)

000006209   Desmoras, J.; Buys, M.; Laurent, L.  (1973) Phosalone Residues in
               Tea: S.U.C.R.P.—D.S.Ph./D.S.An.Nord No. 17389.   (Unpublished
               study  received on unknown date under 3H5038;  prepared by  Societe
               des Usines Chimiques Rhone-Poulenc,  submitted by Rhodia,  Inc.,
               New Brunswick, N.J.; CDL:221773-A)

005017655   Desmoras, J.; Fournel, F.; Laurent, M.; Sauli, M.; Terlain,  B.
               (1971) Etude de la vitesse de degradation  de  la phosalone dans
               le sol, les plantes et les animaux.   [Study of the  speed  of
               degradation of phosalone in soil, plants and  animals.]  Pages
               220-221, _In Proceedings of the 13th  International Congress of
               Entomology; Aug 2-9, 1968, Moscow, USSR.   Vol. 2.   Edited by
               G.Y. Bei-Benko.

005016977   Desmoras, J.; Fournel, J.; Koenig, F.H.;  Metivier, J.  (1964) Etude
               au laboratoire et en serre d'un nouvel ester  phosphorique: la
               phosalone ou 11.974 R.P.   [Laboratory  and  greenhouse
               investigation of a new phosphoric ester: phosalone  or 11,974
               R.P.]  Phytiatrie-Phytopharmacie  13(1):33-43.

-------
                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
000006706   Desmoras, J.; Laurent, M. (1968) Phosalone and Oxygen Analog  (12244
               R.P.): Residues in Apples, Pears and Grapes: R.P.—
               D.S.Ph. No. 12774.  (Unpublished study received Jun  14,  1968
               under 8F0668; prepared by Societe des Usines Chimiques Rhone-
               Poulenc, submitted by Chipman Chemical Co., Inc., Burlingame,
               Calif.; CDL:091171-H)

000006707   Desmoras, J.; Laurent, M.; Aublet, ?; Sasmayoux, ?; Savary, ?
               (1968) Phosalone: Determination of Phosalone, 12244  R.P. and
               20650 R.P. in Fruit from the U.S.A.: R.P.—D.S.Ph./D.S.An.Nord
               No. 12850.  (Unpublished study received Jun 14, 1968 under
               8F0668; prepared by Societe des Usines Chimiques Rhone-Poulenc,
               submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
               CDL:091171-1)

000006648   Desmoras, J.; Laurent, M.; Aublet, J.C.; Savary, M. (1964)  Insecti-
               cides: Metabolism of Residues of 11974 R.P. in Plants  (Sunflow-
               er, Apple Tree, Pear Tree, Cherry Tree) Sprayed in Practical
               Conditions.  R.P.—D.S.Ph./D.R.An. 9511.   (English trans-
               lation; unpublished study received 1965 under 359-EX-46; pre-
               pared by Societe des Usines Chiraiques Rhone-Poulenc, submitted
               by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:123396-1)

005010413   Desmoras, J.; Laurent, M.; Buys, M. (1973) Phosalone.   Pages
               385-397, In Thin-layer and Liquid Chromatography and Analyses
               of Pesticides of International Importance.  Edited by J. Sherma
               and G. Zweig.  New York:  Academic Press.  (Analytical methods
               for pesticides and plant growth regulators, vol. 7)

000006385   Desmoras, J,; Laurent, M.; Metivier, J.; Sauli, M.; Terlain, B.
              (1966) Phosalone: Study on the Degradationof Phosalone  (1974
              R.P.) in Soil: R.P.—D.S.Ph. No. 11423,  (Unpublished study
              received Feb 2, 1967 under 7G0575; prepared by Societe des Usines
              Chimiques Phone-Poulene, submitted by Chimpan Chemical Co., Inc.,
              Burlingame, Calif.; CDL:090727-D)

000006386   Desmoras, J.; Laurent, M.; Terlain, B.; Aublet, J.C.; Sasmayoux,
               J.C.; Savary, M. (1966) Study of the Metabolism of Phosalone
               (11974 R.P.) in Plants: R.P.—D.S.Ph. No.  11686.  (Unpublished
               study received Feb 2, 1967 under 7G0575; prepared by Societe des
               Usines Chimiques Rhone-Poulenc, submitted by Chipman Chemical
               Co., Inc., Burlingame, Calif.; CDL:090727-E)

000006647   Desmoras, J.; Savary, M. (1964) A Bioassay Method for Residue Anal-
               ysis of 11974 R.P.: R.P.—D.S.Ph. No. 9486.  Includes method
               dated Sep 18, 1963.  (English translation; unpublished study re-
               ceived 1965 under 359-EX-46; prepared by Societe des Usines Chi-
               miques Rhone-Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth
               Junction, N.J.; CDL:123396-H)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY  '
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
000006702   Desmoras, J.; Terlain, B.; Savary, M.  (1968) Phosalone:  Identifi-
               cation of Phosalone in Fruit Extracts: R.P.—D.S.Ph./
               D.S.An.Nord No. 12849.  Method dated May 8,  1968.   (Unpublished
               study received Jun 14, 1968 under 8F0668; prepared by Societe
               des Usines Chimiques Rhone-Poulenc, submitted by Chipman Chemi-
               cal Co., Inc., Burlingame, Calif.; CDL:091171-C)

005013769   Dolidze, G.V. (1969) Pestitsidebis shepaseba pitotoksikurobis
               raodenobrivi da tvisobrivi machveneblebit.   [Evaluation of
               pesticides by quantitative and qualitative phytotoxicity
               indicators.]   Soobshcheniya Akademii Nauk Gruzinskoi  SSR.
               54(3):725-728.

000006979   Dorough, H.W.; Randolph, N.M. (1967) Dissipation of Zolone insecti-
               cide from treated alfalfa.  Journal of Economic Entomology 60
               (1):285-286.    (Also In unpublished study received Mar 4, 1976
               under 6F1753; submitted by Rhodia, Inc., Monmouth Junction,
               N.J.; CDL:098088-X)

GS0027011   Drevenkar, V.; Frobe, Z.; Vasilic, Z.; Tkalcevic, B. (1979) The rat
              of urinary excretion of phosalone residues in occupationally
              exposed persons.  Science of the Total Environment 13: 235-243.

005008870   Drevenkar, V.; Stipcevic, M.; Stengl, B.; Stefanac, Z.  (1979) Gas
               chromatographic determination of alkali metal O,0-diethyl
               phosphorodithioate present in trace amounts.  Mikrochimica Acta
               I(5/6):385-394.

000006643   Dubost, P.; Fournel, J.; Ganter, P.; Julou, L.; Koenig,  F.; Myon,
              J.; Bradenbac, J.; Lemoine, F. (1964) Acute Toxicity,  Local
              Tolerance, Anticholinesterase Activity and Chronic Toxicity in
              Rats and Dogs: R.P.—D.S.Ph. 9203.   (English  translation;
              unpublished study received 1965 under 359-EX-46; prepared by
              Societe des Usines Chimiques Rhone-Poulene, submitted  by Rhone-
              Poulenc, Inc., Monmouth Junction, N.J.; CDL:123396-D)

005016593   Dzhashi, V.S.; Bakanidze, M.S. (1975) Materialy o vliyanii
               rabochikh emul'sii fozalona i karbofosa razlichnykh
               kontsentratsii na intensivnost' dykhaniya, aktivnost1 fermenta
               katalazy i na nakoplenie sakharov v mandarinovykh list'yakh.

000008920   E.I. du Pont de Nemours and Company  (1976) Data Supporting the Use
               of Lannate (R)  Methomyl Insecticide and Lannate  (R)  L Methomyl
               Insecticide on Pecans.  Summary of  studies  095289-D through
               095289-S.  (Unpublished study received Sep  21, 1976  under  352-
               342; CDL:095289-C)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005019632   Ebing, W. (1973) Probleme der Rueckstandsanalytik von Bioziden aus
               der Sicht des Umweltschutzes.  [Problems of biocide residue
               analysis as seen from the viewpoint of environmental
               protection.]   Deutsche Lebensmittel-Rundschau 69(1):39-45.

005015711   Eckenrode, C.J.; Robbins, P.S.; Webb, D.R. (1975) 1974 Insecticide
               Research Report on Cabbage Maggot, Seedcorn Maggot, Aphids on
               Lettuce, and Phytotoxicity in Cucumbers.  Geneva, N.Y.:  New
               York State Agricultural Experiment Station. (New York State
               Agricultural Experiment Station, plant sciences: entomology
               (Geneva), no. 9; New York's food and life sciences bulletin no.
               56)

005009880   El-Sayed, M.M.; El-Dorry, H.F.A. (1971) Residues of some
               organo-phosphorus insecticides on squash fruits.  Bulletin of
               the Entomological Society of Egypt, Economic Series V:95-99.

005016098   Esser, H.O. (1971) Terminal residues of organophosphorus
               insecticides in animals.  Pages 33-56, In Pesticide Terminal
               Residues: Invited Papers from the International Symposium on
               Pesticide Terminal Residues; Feb 17-19, 1971, Tel Aviv, Israel.
               Edited by A.S. Tahori.  London:  Butterworths.

005011350   Evdokimov, P.O.; Nekrasova, M.A. (1971) Materialy po toksikologii
               fozalona.  [Data on toxicity of phosalone.]  Sbornik Rabot,
               Leningradskii Veterinarnyi Institut.   [Collection of Works,
               Leningrad Veterinary Institute.]  (32):204-210.

005013968   FAO Panel of Experts on Pesticide Residues and the Environment
               (1977) Pesticide Residues in Food.  Report of the 1976 Joint
               Meeting of the FAO Panel of Experts on Pesticide Residues and
               the Environment and the WHO Expert Group on Pesticide Residues.
               Geneva, Switzerland:  World Health Organization. (WHO technical
               series no. 612; FAO Food and Nutrition series no. 9; FAO Plant
               Production and Protection series no. 8)

005010210   FAO Working Party of Experts on Pesticide Residues (1976)
               Pesticide Residues in Food: Report of the 1975 Joint Meeting of
               the FAO Working Party of Experts on Pesticide Residues and the
               WHO Expert Committee on Pesticide Residues.  Geneva,
               Switzerland:  World Health Organization.  (WHO technical report
               series no. 592; FAO plant production and protection series no.
               1)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
005008484   FAO Working Party of Experts on Pesticide Residues  (1976)
               Pesticide Residues in Food: Report of the 1975 Joint Meeting of
               the FAO Working Party of Experts on Pesticide Residues  and  the
               WHO Expert Committee on Pesticide Residues.  Rome,  Italy:   Food
               and Agriculture Organization of the United Nations.  (FAO plant
               production and protection series no. 1; WHO technical report
               series no. 592)

005013445   FAO Working Party of Experts on Pesticide Residues  (1976)  1975
               Evaluations of Some Pesticide Residues in Food.  By the FAO
               Working Party of Experts on Pesticide Residues and  the  WHO
               Expert Committee on Pesticide Residues.  Geneva, Switzerland:
               World Health Organization.  (WHO pesticide residues  series no.
               5)

005010961   FAO Working Party of Experts on Pesticide Residues  (1976)  1975
               Evaluations of Some Pesticide Residues in Food:  The Monographs.
               By the Joint Meeting of the FAO Working Party of Experts on
               Pesticide Residues and the WHO Expert Committee  on  Pesticide
               Residues.  Geneva, Switzerland:  World Health Organization.
               (WHO technical report series no. 592; FAO plant  production  and
               protection series no. 1; WHO pesticide residue series no. 5)

005007742   Farhat, S.; Baig, M.M.H. (1977) A note on the infrared
               spectrophotometric assay of phosalone alone or in combination
               with DDT.  Pakistan Journal of Scientific and Industrial
               Research 20(1):15-17.

005012643   Fateeva, O.F.; Popova, V.A.  (1978) Khromato-enzymnyy metod
               razdel'nogo opredeleniya  fozalona  i ego metabolitov v plodakh  i
               list'yakh yabloni.   [Chromato-enzymatic determination of
               phosalone and  its metabolites  in apple fruits and  leaves.]
               Khimiya v Sel'skom Khozyaistve.   [Chemistry  in Agriculture.]
               16(l):64-67.

005015526   Ferhat, S.; Baig, M.M.H. (1974) Infra red spectrophotometric
               method of analysis of phosalone and  its DDT mixture.  Pages
               56-56, _In Proceedings of  the Pakistan Science Conference.   Vol.
               25, No.~3.  Lahore, Pakistan:  Pakistan Association for the
               Advancement of Science.

005013738   Fischer, R.; Plazer-Altenburg, D.  (1969) Nachweis von
               Phosphor-Insecticiden in  biologischen Material:  IV.
               Mitteilung.   [Identification of organophosphate  insecticides in
               biological material: part  IV.]  Archives of  Toxicology
               25(2):216-222.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005017631   Floru, S.; Goga, E.; Tucaliuc, M.; Suta, V.; Isac, M.  (1977)
               Reziduuri de pesticide in urma tratamentelor in pomicultura  in
               conditii de productie.  [Pesticide residues after the
               application of treatments in commercial orchards.]  Analele
               Institutului de Cercetari pentru Protectia Plantelor, Academia
               de Stiinte Agricole si Silvice.  [Annals of the Research
               Institute for Plant Protection, Academy of Agricultural and
               Forestry Sciences.] XII:425-435.

005015767   Food and Agriculture Organization of the United Nations,
               Legislative Service (1970) Canada.  Current Food Additives
               Legislation (135):3-5.

000006693   Ford, R.T.G.; Terry, H.J. (1965) Phosalone: An Experiment on the
               Tolerance of Pheasant Chicks to Field Sprays.  (Unpublished
               study received Dec 15, 1966 under 7G0575; prepared by May &
               Baker, Ltd., submitted by Chipman Chemical Co., Inc., Bur-
               lingame, Calif.; CDL:090729-H)

005012942   Forsythe, H.Y., Jr.; Hall, F.R.  (1972) Control of the plum
               curculio in Ohio.  Journal of Economic Entomology
               65(6):1703-1706.

000006399   Fournel, J. (1966) Phosalone: Evaluation of the Choiinesterase
               Activity of the Staff Employed in the Manufacture and Experimen-
               tation of Phosalone (R.P. 11974).  (Unpublished study received
               Feb 2, 1967 under 7G0575; prepared by Societe des Usines Chi-
               miques Rhone-Poulenc, submitted by Chipman Chemical Co., Inc.,
               Burlingame, Calif.; CDL:090727-T)

005010958   Franz, J.M.; Hassan, S.A.; Bogenschuetz, H. (1976) Einige
               Ergebnisse bei der standardisierten Laboratoriumspruefung der
               Auswirkungen von Pflanzenschutzmitteln auf entomophage
               Nutzarthropoden.   [Some results of standardized laboratory
               tests on the effect of pesticides on entomophagous beneficial
               arthropods.]  Nachrichtenblatt des Deutschen
               Pflanzenschutzdienstes (Braunschweig) 28(12):181-183.

005005239   Freed, V.H.; Schmedding, D.; Kohnert, R.; Haque, R.  (1979)
               Physical chemical properties of several organophosphates: some
               implication in environmental  and biological behavior.
               Pesticide Biochemistry and Physiology 10(2):203-211.

005016097   Frehse, H.  (1971) Terminal residues of organophosphorus
               insecticides in plants.  Pages 9-32,  In Pesticide Terminal
               Residues: Invited Papers from the International Symposium on
               Pesticide Terminal Residues; Feb 17-19, 1971, Tel Aviv, Israel.
               Edited by A.S. Tahori.  London:  Butterworths.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005015911   Frolov, B.A.; Kachekova, S.; Stepushin, A.E.; Bulatov, R.M.;
               Furygin, E.A.  (1976) Insektitsid benzofosfat kak sredstvo
               bor'by s klopom Cimex lectularius L. v ptichnikakh.   [Use of
               insecticide benzophosphate for control of bug Cimex
               Sanitarii 52:175-178.

005008442   Gallo, M.A. (1975) Studies on the toxicity of phosalone  [abstract
               no. 55].  Toxicology and Applied Pharmacology 33(1):144.

005018186   Gallo, M.A.; Wang, D.I., inventors; Rhodia,  Inc., assignee  (1977)
               Synergistic pesticidal mixtures of phosalone and malathion and
               process  for controlling arthropods therewith.  U.S. patent
               4,064,237.  Dec 20.  8 p. Int. Cl.               424/200.

005008921   Gauer, W.O.; Seiber, J.N.  (1971) Analysis of Zolone
               insecticide-acaricide on grapes.  Bulletin of Environmental
               Contamination  and Toxicology 6(2):183-188.

005014814   Gergaya, M.S.; Bezhanidze, A.A. (1977) Dinamika razlozheniya
               pestitsidov v  zelenykh list'yakh chaya.   [The rate of pesticide
               breakdown in green tea leaves.]  Khimiya v Sel'skom
               Khozyaistve.   [Chemistry in Agriculture.] 15(3):75-77.

005016976   Gerig, L.  (1974)  Bienen und geplante Maikaeferbekaempfung im Kt.
               Thurgau  1973.   [Bees and organized cockchafer control in
               Thurgau  Canton 1973.]  Schweizerische Bienen-Zeitung
               97(6):256-264.

005019860   Gladenko, I.N.; Alekseenko, P.M.; Yaroshenko, V.I. (1973)
               Opasnost1 dlya pchel nekotorykh fosfororganicheskikh
               yadokhimikatov.   [The danger to bees of certain
               organophosphorus toxic chemicals.]  Veterinariya (Moscow).

005011367   Glukhova, L.G.; Vasilenko, T.E.; Apon, N.I.  (1978) Sravnitel'naya
               kharakteristika vliyaniya khlor- i fosfororganicheskikh
               yadokhimikatov na zhelcheobrazovatel'nuyu funktsiyu pecheni.
               and organophosphorus pesticides on the biligenic function of
               the liver.]  Vrachebnoe Delo.   [Medical Profession.]
               (11):130-131.

005013287   Grebenshchikova,  V.M. (1977) Sokrashchennye  skhemy obrabotok
               protiv yablonnoi plodozhorki.   [Shortened methods of  treatment
               against  the codling moth.]  Vestnik Sel'skokhozyaistvennoi
               Nauki Kazakhstana.   [Journal of Agricultural Science of
               Kazakhstan.] 20(5):57-59.

005012134   Greenstone, E.S.  (1975) Farmworkers in jeopardy: OSHA, EPA, and
               the pesticide  hazard.  Ecology Law Quarterly 5(1):69-137.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005020112   Grishchenko, L.I.; Verkhovskii, A.P.; Trondina, G.A.  (1975)
               Toksichnost1 benzofosfata (fozalona) dlia ryb i diagnostika
               otravlenii.  [Toxicity of benzophosphate (phosalone) for fish
               and diagnosis of poisonings.]  Byulleten Vsesoyuznogo Instituta
               Eksperimental'noi Veterinarii.   [Bulletin of the Ail-Union
               Institute of Experimental Veterinary Medicine.]  (20):58-61.

000006400   Guardigli, A.  (19??) Laboratory Comments: Field Test  Project
               No. PAS 66-80—Cotton—RP-11974—Dumas, Arkansas.   (Unpublished
               study received Mar 6, 1967 under 7G0575; prepared  by Rhodia,
               Inc., submitted by Chipman Chemical Co., Inc., Burlingame,
               Calif.; CDL:092863-A)

000006389   Guardigli, A.  (1964) Laboratory Analytical Data Sheet for Residues
               of R.P. 11974:  [Phosalone].  (Unpublished study received Feb 2,
               1967 under 7G0575; prepared by Rhodia, Inc., submitted by Chip-
               man Chemical Co., Inc., Burlingame, Calif.; CDL:090727-H)

000006769   Guardigli, A.  (1964) Laboratory Analytical Data Sheet for Residues:
               Field Test Project No. BB 64-26.   (Unpublished study received
               Feb 2, 1967 under 7G0575; prepared by Rhodia, Inc., submitted
               by Chipman Chemical Co., Inc., Burlingame, Calif.;  CDL:090727-L)

000006388   Guardigli, A.  (1965) Residue Summary Sheet: [Phosalone].  (Unpub-
               lished study including project nos. BB 10-64-12, BB 12-64-20,
               BB 64-26, BB 65-18, BB 65-27, BB 65-47, BB 65-49,  BB 65-127,
               C 64-12, C 65-17, C 65-30 and Port 65-47, received Feb 2, 1967
               under 7G0575; prepared by Rhodia,  Inc., submitted  by Chipman
               Chemical Co., Inc., Burlingame, Calif.; CDL:090727-G)

000006680   Guardigli, A.  (1966) Comparison of Residues of Phosalone in Alfalfa
               Samples: Project Nos. BB 66-79 and C 66-22.   (Unpublished study
               received Jun 14, 1968 under 8F0668; prepared by Rhodia, Inc.,
               submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
               CDL:091170-1)

000006391   Guardigli, A.  (1966) Laboratory Analytical Data Sheet for Residues:
               Field Test Project No. BB 66-126.  (Unpublished study received
               Feb 2, 1967 under 7G0575; prepared by Rhodia, Inc., submitted by
               Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090727-J)

000006714   Guardigli, A.  (1966) Laboratory Raw Analytical Data.   (Unpublished
               study including letter dated Feb 9, 1965 from L. Farber to L.
               Reed and test nos. BB-64-26, BB-65-125, C-64-12, C-65-27, Port-
               65-66 and Port 66-12, received Jun 14, 1968 under  8F0668; pre-
               pared by Rhodia, Inc., submitted by Chipman Chemical Co., Inc.,
               Burlingame, Calif.; CDL:091171-AD)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be  Inappropriate  For Use  in
                           Developing the Standard
000006392   Guardigli, A.  (1966) Residue Summary Sheet:  [Phosalone].   (Unpub-
               lished study including project nos. BB  64-26, BB  65-125,  C 64-
               12, C 65-27, Port 65-66 and Port 66-12, received  Feb 2,  1967
               under 7G0575; prepared by Rhodia, Inc., submitted by Chipman
               Chemical Co., Inc., Burlingame, Calif.; CDL:090727-K)

000006390   Guardigli, A.  (1966) Residue Summary Sheet:  [Phosalone].   (Unpub-
               lished study including project nos. C-64-12  and BB-65-63,  re-
               ceived Feb  2, 1967 under 7G0575; prepared by Rhodia,  Inc.,  sub-
               mitted by Chipman Chemical Co., Inc., Burlingame, Calif.;  CDL:
               090727-1)

000006395   Guardigli, A.  (1966) Residue Summary Sheet:  [Phosalone].   (Unpub-
               lished study including project nos. C 64-16, C 65-44,  BB 65-42
               and BB 65-51, received Feb 2, 1967 under 7G0575; prepared  by
               Rhodia, Inc., submitted by Chipman Chemical  Co.,  Inc.,  Burlin-
               game, Calif.; CDL.-090727-O)

000006070   Guardigli, A.  (1967) Analytical Procedure  for Phosalone Residue
               Determination in Milk and Animal Tissues by  Electron Capture
               Chromatography.  Method No. 54-C dated  Aug 14, 1967.   (Unpub-
               lished study received Sep 12, 1968 under 9F0759;  submitted by
               Rhodia, Inc., New Brunswick, N.J.; CDL:093071-D)

000006681   Guardigli, A.  (1967) Laboratory Analytical Data Sheet  for Residues:
               Field Test  Project No. SR 64-300.   (Unpublished study including
               letter dated Feb 1, 1965 from L. Farber to L. Reed  and  field
               test project nos. PA 66-47, PAS 65-39,  PAS 65-40; PAS 65-49,  PAS
               66-80 and PAS 66-92, received Jun 14, 1968 under  8F0668;  pre-
               pared by Rhodia, Inc., submitted by Chipman  Chemical Co.,  Inc.,
               Burlingame, Calif.; CDL:091170-J)

000006713   Guardigli, A.  (1967) Laboratory Raw Analytical  Data.   (Unpublished
               study including letter dated Mar 2, 1965 from L.  Farber to L.
               Reed and field test project nos. BB-65-63, BB-67-100,  C 64-12,
               and PA 67-28, received Jun 14, 1968 under 8F0668; prepared by
               Rhodia, Inc., submitted by Chipman Chemical  Co.,  Inc.,
               Burlingame, Calif.; CDL:091171-Z)

000006174   Guardigli, A.  (1967) Phosalone  (RP 11974)  (Zolone)—Recovery from
               Acid Delinted Cotton Seed.   (Unpublished  study received Oct 18,
               1967 under  unknown admin, no.; prepared by  Chipman  Chemical Co.,
               Inc., submitted by Rhone-Poulenc,  Inc., Monmouth  Junction, N.J.;
               CDL:123376-A)

000006393   Guardigli, A.  (1967) Residue Summary Sheet:  [Phosalone].  (Unpub-
               lished study including project nos. SR  64-300,  PAS  65-39, PAS
               65-40, PAS  65-49, PAS 66-47, PAS  66-80  and  PA 66-92, received
               Feb 2, 1967 under 7G0575; prepared by Rhodia,  Inc., submitted
               by Chipman  Chemical Co.,  Inc., Burlingame,  Calif.;  CDL:090727-M)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
OC0006394   Guardigli, A. (1967) Residue Summary Sheet: Field Test Project
               No. Port 66-11.  (Unpublished study received Feb 2, 1967 under
               7G0575; prepared by Rhodia, Inc., submitted by Chipman Chemical
               Co., Inc., Burlingame, Calif.; CDL:090727-N)

000006711   Guardigli, A. (1968) Results of Tests on the Amount of Residue Re-
               maining.  (Unpublished study including letters dated Dec 9,
               1964, Jan 21, 1965 and Oct 1, 1965 from L. Farber to L. Reed
               and field test nos. BB-10-64-12, BB-64-10, BB-64-26, BB-65-47,
               BB-65-49, BB-65-127, C-64-12, C-65-17; C-65-30, C-66-32,
               C-66-33, PA-66-32, PA-67-58 and Port-65-47, received Jun 14,
               1968 under 8F0668; prepared by Rhodia, Inc., submitted by Chip-
               man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-N)

000006575   Guardigli, A. (1972) Leaching Studies on Phosalone: Laboratory Ex-
               periments.  (Unpublished study received May 25, 1973 under
               3F1337; submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:
               093575-C)

000006068   Guardigli, A. (1972) Phosalone Transfer in Fruits Processing:
               Possible Residue in Raw Apple Juice and Dry Apple Pomace: Labo-
               ratory Experiments.  (Unpublished study received Feb 16, 1972
               under 2H5013; submitted by Rhodia, Inc., New Brunswick, N.J.;
               CDL:221747-C)

000006971   Guardigli, A. (1973) Residue Studies in the Milk and Tissues of
               Dairy Cows Fed Phosalone.  (Unpublished study received Mar 4,
               1976 under 6F1753; submitted by Rhodia, Inc., Monmouth Junction,
               N.J.; CDL:098088-L)

000006994   Guardigli, A. (1974) Residue Studies in Tissues and Eggs of Bob-
               white Quail Fed Phosalone.   (Unpublished study received Mar 4,
               1976 under 6F1753; prepared in cooperation with Bio/dynamics,
               Inc., submitted by Rhodia, Inc., Monmouth Junction, N.J.; CDL:
               098088-T)

000006495   Guardigli, A. (1974) Residue Studies in Tissues and Eggs of Bob-
               white Quail Fed Phosalone.   (Unpublished study received Jun 13,
               1974 under 359-620; prepared by Rhodia, Inc. in cooperation with
               Bio-dynamics, Inc., submitted by Rhone-Poulenc, Inc., Monmouth
               Junction, N.J.; CDL:120351-W)

000006980   Guardigli, A. (1974) Residue Studies in Tissues and Eggs of Poultry
               Fed Dietary Phosalone.  (Unpublished study received Mar 4, 1976
               under 6F1753; submitted by Rhodia, Inc., Monmouth Junction,
               N.J.; CDL:098088-Y)

-------
                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be  Inappropriate  For Use  in
                           Developing the Standard
000006970   Guardigli, A.  (1975) Phosalone Oxygen Analog  (Oxon)  Residues  in/on
               Alfalfa.  (Unpublished study  including residue reports  111973-
               053, 170473-055, 191573-004,  191573-028, 213673-024,  263174-003
               and 263774-010, received Mar  4, 1976 under  6F1753; submitted  by
               Rhcdia, Inc., Monmouth Junction, N.J.; CDL:098088-K)

000006969   Guardigli, A.  (1975) Phosalone Residues in/on  Alfalfa.   (Unpub-
               lished study including residue reports 111973-053, 170473-055,
               191573-004, 191573-028, 213673-024, 222173-045, 263174-003 and
               263774-010, received Mar 4, 1976 under 6F1753; submitted by
               Rhcdia, Inc., Monmouth Junction, N.J.; CDL:098088-J)

000006679   Guardigli, A.; Lienk, S.E. (1967) Laboratory Analytical  Data  Sheet
               for Residues: Field Test Project No. BB  67-79.  (Unpublished
               study received Jun 14, 1968 under 8F0668; prepared by Rhcdia,
               Inc., submitted by Chipman Chemical Co., Inc., Burlingame,
               Calif.; CDL:091170-H)

000006783   Guardigli, A.; Martwinski, P. (1969) Phosalone Residues  on Apples
               Treated with Zolone 25% Wettable Powder  at  Several Application
               Rates.  (Unpublished study including field  test project nos. AT
               69.16-AT 69.17, BB 68-66, BB  69.7-BB 69.9,  Port 68-12 and  Port
               69-56, received Dec 22, 1969  under 359-626; prepared  by Rhcdia,
               Inc., submitted by Rhone-Poulenc, Inc.,  Monmouth  Junction,  N.J.;
               CDL:003174-W)

000006358   Guardigli, A.; Martwinski, P. (1970) Results of Almond Residue
               Tests: Part D.   (Unpublished  study including field test project
               nos. PAW 69-5, PAW 69-6, PAW  69-9, PAW 69-13, PAW 69-18 and
               PAW 68-18, received Jun 26, 1972 under OF0983; submitted by
               Rhcdia, Inc., New Brunswick,  N.J.; CDL:091691-J)

000006511   Guardigli, A.; Martwinski, P. (1970) Results of Residue  Tests.
               (Unpublished study including  report nos. AT 69-14, AT 69-20, AT
               69-22, AT 69-47, PA 67-45, PA 68-50, PA  69-29, PAS 67-77,  PAW
               69-2 and PAW 69-7, received Mar 12, 1970 under OF0948;  submitted
               by Rhcdia, Inc., New Brunswick, N.J.; CDL:091617-B)

000006480   Guardigli, A.; Martwinski, P. (1971) Residue Data:  [Zolone].   (Un-
               published study including field test project nos. BB  65-63, BB
               68-91, PA 68-46, PA 70-25/25A, PA 70-26, PA 70-27/27A and  PAW
               70-29, received Nov 18, 1971  under 359-626; prepared  by Rhodia,
               Inc., submitted by Rhone-Poulenc, Inc.,  Monmouth  Junction, N.J.;
               CDL:003175-X)

-------
                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
000006576   Guardigli, A.; Martwinski, P. (1972) Phosalone—Potato Petition:
               Residue Summary—Potatoes.  (Unpublished study including  field
               test project nos. AT 71-15, BB 68-87, BB 68-94, BB 69-60, C  66-
               41, CH 71-61, CH 71-84, CH 71-103, FW 71-52 and Port 71-30,
               received May 25, 1973 under 3F1337; submitted by Rhcdia,  Inc.,
               New Brunswick, N.J.; CDL:093575-E)

000006086   Guillot, ?; Kauffmann, ?  (1968) Insecticides: Phosalone:  Flavor
               Study in Apples: R.P.—C.E. Ag Emerainville No. 362.   (Unpub-
               lished study received Aug 19, 1971 under 2F1193; prepared by
               Rhone-Poulenc, submitted by Rhodia, Inc., New Brunswick, N.J.;
               CDL:093518-B)

005015531   Gusein-Adzhiev, Z.K.; Kan, P.T. (1976) Toksichnost1 benzofosfata
               dlya krupnogo pogatogo skota i ovets pri naruzbnom primenenii.
               external application.]  Trudy, Vsesoyuznyi
               Nauchno-Issledovatel'skii Institut Veterinarnoi Sanitarii.
               Veterinary Sanitation.] 52:135-141.

005013768   Gusein-Adzhiev, Z.K.; Leshchev, V.V.  (1976) 0 bydelyenii
               benzofosfata v moloko pri obrabotke korov protiv iksodovykh
               kleshchei.   [The excretion of benzophosphate into milk by cows
               treated against ixodes ticks.]  Trudy, Vsesoyuznyi
               Nauchno-Issledovatel'skii Institut Veterinarnoi Sanitarii.
               Veterinary Sanitation.] 52:149-151.

005005527   Hassan, S.A.  (1977) Standardized techniques for testing
               side-effects of pesticides on beneficial arthropods in the
               laboratory.  Zeitschrift fuer Pflanzenkrankheiten und
               Pflanzenschutz.  [Journal of Plant Diseases and Protection.]
               84(3):158-163.

GS0027017   Hastings, S.F.  (1977) Acute Oral LD™ in Mallard Ducks with
              Phosalone Technical.  Project No. CH-68.  Report No. SEH 77:9.
              (Unpublished study received Dec, 1980 under 6F1753; prepared  by
              Rhodia, Inc., Hess and Clark Division, Submitted by Rhodia, Inc.)

000006964   Henckler, P.  (1973) Project Number 170473-008.  (Unpublished study
               including letter dated Nov 6, 1973 from D.I. Wang to C.C. Comp-
               ton, received Oct 18, 1973 under 3E1401; prepared by Rhodia,
               Inc., submitted by Interregional Research Project No.  4, New
               Brunswick, N.J.; CDL:098195-A)

000006107   Henckler, P.  (1973) Specific Analytical Method for Technical Phosa-
               lone and Its Formulations: Liquid and Wettable Powders.  Method
               no. 124 dated Nov 1973.   (Unpublished study received Mar  4,  1976
               under 6F1753; submitted by Rhodia, Inc., Monmouth Junction,
               N.J.; CDL:095979-D)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be  Inappropriate For Use  in
                           Developing the Standard
000006483   Henckler, P.M.; Dennis, S.  (1973) Residue Summary: Apricots.   (Un-
               published study including residue  final report nos.  170473-042
               and 170473-053, received Mar  29, 1974 under  359-620; prepared by
               Rhodia, Inc., submitted by Rhone-Poulenc,  Inc., Monmouth Junc-
               tion, N.J.; CDL:028124-C)

000006484   Henckler, P.M.; Dennis, S.; Collins,  R.  (1973)  Residue  Summary:
               Cherries.   (Unpublished study including residue final  report
               nos. 170473-041 (A), 170473-041  (B) and 213673-013,  received Mar
               29, 1974 under 359-620; prepared by Rhodia,  Inc.,  submitted by
               Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:028124-D)

000006124   Henckler, P.M.; Reed, J.P.  (1974) Zolone—Carrot: Residue Final Re-
               port No. 112973-133.   (Unpublished study  received  Feb  12,  1974
               under 4E1468; prepared  in cooperation with Rutgers Univ.,  Dept.
               of Entomology, submitted by Interregional  Research Project
               No. 4, New  Brunswick, N.J.; CDL:093909-A)

000006485   Henckler, P.M.; Rice, R.  (1973)  Residue Summary: Nectarines:  Pro-
               ject No. 180473-032.   (Unpublished study  received  Mar  29,  1974
               under 359-620; prepared by Rhodia, Inc. in cooperation with
               Univ. of California, submitted by  Rhone-Poulenc, Inc.,  Monmouth
               Junction, N.J.; CDL:028124-E)

000006487   Henckler, P.M.; Rice, R.  (1973)  Residue Summary: Plums: Project
               No. 180473-033.   (Unpublished study received Mar 29, 1974  under
               359-620; prepared by Rhodia,  Inc.  in cooperation with  Univ. of
               California, submitted by Rhone-Poulenc, Inc., Monmouth Junction,
               N.J.; CDL:028124-G)

000006486   Henckler, P.M.; Taylor, J.C.; Corner, G.; Dennis, S.  (1973) Residue
               Summary: Peaches.   (Unpublished  study including residue final
               report nos. ARK 72-77,  123973-023  and 170473-072,  received Mar
               29, 1974 under 359-620; prepared by Rhodia,  Inc. in  cooperation
               with Louisiana State Univ. and Clemson Univ., submitted by
               Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:028124-F)

005009331   Hislop, R.G.;  Acker, C.; Prokopy, R.J.  (1977) Influence of
               pesticides  on predacious and  phytophagous mite populations in
               Massachusetts apple orchards.  Journal of the New  York
               Entomological Society 85(4):180.

005015532   Husein, F.; Gouhar, K.A.;  Guirguis, M.W.  (1975) Effect  of certain
               organophosphorus  insecticides on fruit quality of  Valencia
               orange.  Annals of Agricultural  Science,  Moshtohor 3:163-171.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005017964   Iren, Z. (1972) Baglarda ciceklenme devresinde kullanilan bazi
               ilaclarin orta anadolu bolgesinde dollenmeye olan etkilerinin
               arastirilmasi.  [Investigation into the effects of certain
               chemicals on fertilization of vines in blosson time in central
               Anatolia.]  Pages 44-45, _In Zirai Mucadele Arastirma Yilligi.
               Zirai Mucadele Arastirma Enstitusu.

005006342   Ishitani, A.; Yukimoto, M.; Yoshida, K. (1975) Nogaku no
               kakushusakubutsu ni taisuru yakugai ni tsuite: II.  Yuki rinkei
               satchuzai.  [Phytotoxicities of agricultural chemicals to
               crops: II.  Organophosphorus insecticides.]  Noyaku Kensasho
               Hokoku.   [Bulletin of the Agricultural Chemicals Inspection
               Station.] (15):92-97.

005016273   Ivanova, L.N.; Molozhanova, E.G. (1974) 0 kinetike prevrashcheniya
               nekotorykh pestitsidov v pochve.   [The transformation kinetics
               of certain pesticides in soil.]   Khimiya v Sel'skom
               Khozyaistve.   [Chemistry in Agriculture.] 12(5):363-365.

005014687   Ivanova, L.N.; Russu-Lupan, I.T.; Belaya, L.L.; Fedorchenko, V.S.;
               Mamusevich, T.I. (1975) 0 verifikatsii prognoza dinamiki
               pestitsidov v produktahk rastenievodstva.  [On verification of
               prognosis on the dynamics of pesticides in products of plant
               cultivation.]  Gigiena i Sanitariya.   [Hygiene and Sanitation.]
               40(6):105-107.

005010956   Jenik, M.; Madaric, A.; Gecova, K.  (1975) Stanovenie
               organofosforovych insekticidov v ovzdusi.  [The determination
               of organophosphorus insecticides in the atmosphere.]
               Ceskoslovenska Hygiena.   [Czechoslovak Hygiene.] 20(2):83-89.

005013290   Kachekova, S.; Frolov, B.A.; Riazhenov, N.I. (1975) Dinamika
               ostatkov benzofosfata v organakh i tkaniakh obrabotannykh kur.
               treated chickens.]   Trudy, Vsesoyuznyi
               Nauchno-Issledovatel'skii Institut Veterinarnoi Sanitarii.
               Veterinary Sanitation.] 51:96-99.

005010804   Kagan, Y.S.; Vojtenko, G.A.; Svetlij, S.S.; Zlatjev, Z.  (1975) A
               method for the quantitative evaluation of combined and complex
               pesticide effects on organisms.   Pages 631-635, _In Pesticides:
               International Union of Pure and Applied Chemistry Third
               International Congress; Jul 3-9, 1974, Helsinki, Finland.
               Edited by F. Coulston and F. Korte.  Stuttgart, West Germany:
               George Thieme.  (Environmental quality and safety supplement,
               vol. Ill)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005015385   Kamil'dzhanov, A.K.  (1970) Zagryaznenie atmosfernogo vozdukha
               fozalonom pri primenenii ego v sel'skom khozyaystve v
               usloviyakh Uzbekistana.   [Contamination of the atmosphere with
               phosalone during  its agricultural use in Uzbekistan.]
               Meditsinskii Zhurnal Uzbekistana.   [Medical Journal of
               Uzbekistan.] (10):122-123.

005013291   Kamil'dzhanov, A.K.  (1975) Srednesutochnaia predel'no dopustimaia
               kontsentratsiia fozalona v atmosfernom vozdukhe.   [Average
               daily maximum permissible concentration of phosalone in the
               atmosphere.]  Meditsinskii Zhurnal Uzbekistana.   [Medical
               Journal of Uzbekistan.] (10):53-56.

005015130   Kamil'dzhanov, A.K.; Khasanov, Y.U.  (1971) Ob ostatochnykh
               kolichestvakh fozalona v obrabotannykh im yablokakh i
               lyutserne.   [Phosalone residues in treated apples and alfalfa.]
               Gigiena i Sanitariya.   [Hygiene and Sanitation.] 36(6):104-105.

005017832   Kanarev, G.; Mateeva, A.  (1975) Vliyanir na nyakoi pestitsidi
               v'rkhu koprinenata buba.   [Effect of some pesticides on
               silkworms.]  Priroda (Sofia).   [Nature.] 24(2):65-66.

005009436   Kapitan, A.I.; Sukhoruchenko, G.I.; Tolstova, Y.S.  (1972)
               Toksichnost' pestitisidov dlya zlatoglazki.   [Toxicity of
               pesticides for aphid lions.]  Zashchita Rastenii  (Moscow).

005016277   Karadzhov, S. (1973) Dinamika na rastitelnoyadnite i khishtnite
               akari pri biologichna sistema za borba s nepriyatelite po
               yabulkata.   [Dynamics of the phytophagous and predacious mites
               in a biological system of pest control of apple.]  Gradinarska
               i Lozarska Nauka.   [Horticultural and Viticultural Sciences.]
               X(5):51-62.

005008877   Kawamura, Y.; Takeda, M.; Uchiyama, M. (1978) Studies on analysis
               of pesticide residues  in foods  (XXVIII): Determination of 33
               organophosphorus  pesticides in agricultural crops.  Journal of
               Food Hygienic Society of Japan 19(6):518-523.

005013292   Khalpaev, O.S.; Akhmedzhanov, K.A. (1973) Tsitokhimicheskie i
               drugie pokazateli perifericheskoi krovi pri ostrykh
               otravleniiakh fozalonom v eksperimente.   [Cytochemical and
               other indices of peripheral blood during experimental acute
               poisoning with phosalone.]  Meditsinskii Zhurnal Uzbekistana.

005014953   Khan, S.A.; Shafique, R.M.; Kahn, B.A. (1973) Phytotoxicity caused
               by pesticides in  Brassica.  Journal of Agricultural Research
               (Lahore) 11(1):55-68.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005013534
005016710
005016365
005016275
005014545
005011360
005014888
000006966
005015138
Khasanov, Y.U. (1974) Vliianie nekotorykh pestitsidov i
   mineral 'nykh udobrenii na sintez vitaminov v
   ovoshche-bakchevykh i fruktovykh kul'turakh.   [Effect of some
   pesticides and mineral fertilizers on synthesis of vitamins in
   cucurbitaceous vegetable and fruit cultures.]  Meditsinskii
   Zhurnal Uzbekistana.  [Medical Journal of Uzbekistan.]
Khasanov, Y.U. ; Rasulev, B.D. (1970) Ostatochnyye kolichestva
   antio, rogora, fozalona i DDT v yablokakh i lyutserne.
   apples and alfalfa.]  Meditsinskii Zhurnal Uzbekistana.

Khukhrii, O.V. (1974) Diya insektytsydiv na Aphid ius ervi Hal.,
   parazita horokhovoyi popelytsi ( Acyrthos iphon pisum Harr.).
   of the pea aphid  ( Acyrthos iphon pisum Harr.).]  Zashchita
   Rastenii (Kiev).   [Plant Protection.] (20):25-27.

Khushcha, V.L. (1978) Fitotoksychnist '  pestytsydiv pry
   ul ' tramaloob ' yemnomu obpryskuvanni u sadakh.   [Phytotoxicity of
   pesticides following ultralow volume spraying in orchards.]
   Visnik Sil's'kogospodars'koi Nauki.   [Journal of Agricultural
   Science.]  (1): 28-30.

Kiguradze, K.T. ; Ordzhonikidze, E.K. (1977) Pospororganuli
   insektitsidebis gavlena mtsenaris zrda-ganvitarebasa da
   nakopebis biokimiur machveneblebze .   [The effect of
   organophosphorus  insecticides on the plant growth and
   development of plants and the biochemical indicators of fruit.]
   Soobshcheniya Akademii Nauk Gruzinskoi SSR.   [Bulletin of the
   Academy of Sciences of the Georgian SSR.] 86 (2): 461-464.

Kim, N.G. ; Guzeev, G.F.; Khalilov, S.K. (1977) Vliyanie
   pestitsidov na entomofaunu orekhovoplodovykh lesov Srednei
   Asii.   [Effect of pesticides on entomofauna of nut-fruit tree
   forests of Central Asia.]  Khimiya v Sel'skom Khozyaistve.

Kisilenko, M.A. ; Pis'mennaya, M.V.  (1973) Opredeleniye fozalona,
   ftalofosa, fenkaptona, tsideala i sayfosa v vode.
   and sayfos in water.]  Metody Opredeleniya Pestitsidov v Vode.
   (1): 27-32.

Kitching, U. , tr.  (1975) On the Prognosis of Phosalone Residues in
   Water Reservoirs: S.U.C.R.P.— D.S.Ph. No. 17733.   (English
   translation; unpublished study received Mar 4, 1976 under
   6F1753; submitted by Phodia, Inc., Monmouth Junction, N. J. ; CDL:
   098088-F)

Klisenko, M.A. ; Pis'mennaya, M.V. ; Novitskaya, L.P. ; Brodskaya,
   N.M.  (1968) Opredelenie ftalofosa i fozalona v vozdukhe.
   Sanitariya.   [Hygiene and Sanitation.] 32 (8): 67-70.

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                          OFFICE OF  PESTICIDE  PROGRAMS
                       REGISTRATION  STANDARD BIBLIOGRAPHY
           Citations Examined and Judged  to be Inappropriate For Use in
                           Developing  the Standard
GS0027012   Knaak, J.B.; Maddy,  K.T.;  Gallo,  M.A.;  Lillie,  D.T.;  Craine,  E.M.:
              Serat, W.F.  (1978) Worker  reentry studiues involving phosalone
              application  to  citrus groves.   Toxicology and Applied
              Pharmacology 46:  363-374.

GS0020713   Knaak, J.B.; Schlocker, P.;  Ackerman,  C.R.; Seiber, J.N.  (1980)
              Reentry  research:  Establishment of safe pesticide levels on
              foliage.  Bull.  Environm.  Contam. Toxicol. 24: 769-804.

000006088   Knobel, H.  (1971)  Final Report:  District Project No.  AT 71-32.
                (Unpublished study  received on unknown date  under  2F1193;  pre-
               pared in cooperation with Coca Cola Co., submitted by Rhodia,
               Inc., New Brunswick, N.J.; CDL:093518-E)

000006089   Knobel, H.  (1971)  Final Report:  District Project No.  AT 71-33.
                (Unpublished study  received on unknown date  under  2F1193;  pre-
               pared in cooperation with Coca Cola Co., submitted by Rhodia,
               Inc., New Brunswick, N.J.; CDL:093518-F)

000006538   Knobel, H.; Estes,  P.  (1968)  Report No. AT  68-41.  (Unpublished
               study received Feb  16,  1970 under OF0948; prepared in coopera-
               tion with Auburn Univ., submitted by Rhodia, Inc., New Bruns-
               wick, N.J.; CDL:092026-U)

000006938   Knobel, H. ; Rock,  G.  (1969)  Summary Report: District  Project  No. AT
               69-16.   (Unpublished study received Dec  22,  1969 under 359-626;
               prepared in cooperation with  North Carolina  State  Univ., Dept.
               of Entomology,  submitted  by Rhone-Poulenc, Inc., Monmouth  Junc-
               tion, N.J.; CDL:003174-R)

000006939   Knobel, H.; Rock,  G.  (1969)  Summary Report: District  Project  No. AT
               69-17.   (Unpublished study received Dec  22,  1969 under 359-626;
               prepared in cooperation with  North Carolina  State  Univ., Dept.
               of Entomology,  submitted  by Rhone-Poulenc, Inc., Monnouth  Junc-
               tion, N.J.; CDL:003174-S)

000014908   Koehler, C.S.; Jurich, R.; Frobase, J.; et  al.  (1978) Field Evalua-
               tion Report on the  Use  of Orthene/Medicap Systemic Tree Injec-
               tion Cartridges:  FEP No.  1-73-10.   (Unpublished study including
               letter  dated Feb 3, 1978  from J. O'Neal  to Warren  D. Wolfe and
               FEP nos. 0-76-7,  0-76-8,  0-76-9..., received Mar 6, 1979 under
               37979-1; submitted  by Creative Sales, Inc.,  Fremont, Nebr.;
               CDL:237989-B)

005014549   Kol'kovski, P.G.; Kavakova,  Y.D. (1974) Ekspressivnyi metod
               opredeleniia BI-58  i  fosalona v vozdukhe.   [Express method for
                the determination of BI-58 and phosalone in the air.]  Gigiena
                i Sanitariya.   [Hygiene and  Sanitation.] 4:83-86.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005015136   Konyukhov, A.F- (1975) Metody obnaruzheniya fosfororganicheskikh
               pestisidov v organakh i tkanyakh zhivotnykh, kormakh i vode.
               organs and tissues of animals, in foodstuffs, and in water.]
               Trudy Vsesoyunogo Instituta Eksperimental'noi Veterinarii.
               Veterinary Science.]  43:346-358.

005014055   Konyukhov, A.F. (1975) Obnaruzhenie fosalona v patologicheskom
               materiale.  [Detection of phosalone in pathological specimens.]
               Veterinariya (Moscow).  [Veterinary Science.] (4):93-94.

005016360   Konyukhov, A.F. (1975) Opredelenie fozalona v kombikormakh.   [The
               determination of phosalone in mixed feeds.]  Veterinariya
               (Moscow).   [Veterinary Science.] (l):84-85.

005015389   Konyukhov, A.F.; Poloz, D.D.; Kokhtyuk, F.P.  (1975) Nakoplenie i
               dlitel'nost' cokhraneniia fosalona v organakh kur pri ostrom
               otravlenii.  [Accumulation and persistance of phosalone in the
               organs of chickens after acute poisoning.]  Khimiya v Sel'skom
               Khozyaistve.  [Chemistry in Agriculture.] 13(6):459-460.

005014056   Korzhevenko, G.N.; Leshchev, V.V.; Metelev, V.V.; Brichko, V.F.
               (1976) Uskorennyi metod diagnostiki otravlenii ryb
               fosfororganichimi pestitsidami.  [Rapid diagnosis of
               organophosphorus pesticide poisoning in fish.]  Veterinariya
               (Moscow).   [Veterinary Science.] (9):90-92.

005013446   Kosmatyi, E.S.; Tverskaya, B.M.; Polonskaya, F.I. (1972)
               Opredelenie
               0,O-dietil-S-(6-khlorbenzoksazolinil-3-metil)ditiofosfata
               (fozalona) v yablokakh metodom tonkosloinoi khromatografii.
               0,0-d iethyl-S-(6-chlorobenzoxazolin-3-ylmethyl)d ithiophosphate
               (phosalone) in apples by thin-layer chromatography.]  Problemy
               Analiticheskoi Khimii.  [Problems of Analytical Chemistry.]
               2:70-73.

005016119   Kuteev, F.S.; Zharkikh, M.D. (1974) Primeneniye
               kolorimetricheskikh metodov dlya opredeleniya khlorofosa,
               benzofosfata i metilnitrofosa v ob'yektakh lesnogo biotsenoza.
               Use of colorimetric methods for determination of chlorophos,
               benzophosphate and methylnitrophos in objects of the forest
               biocenose (residues).]  Khimiya v Sel'skom Khozyaistve.

005016025   Kuz'minskaya, U.A.; Yakushenko, V.E.; Bersan, L.V. (1978)
               Vozdeystviye dlitel'nogo postupleniya nekotorykh pestitsidov na
               aktivnost1 detoksitsiruyushchey sistemy pecheni.   [Effect of
               long-term exposure to pesticides on the detoxifying activity of
               the liver.] [abstract].  Gigiena Truda i Professional'nye
               Zabolevaniya.  [Labor Hygiene and Occupational Diseases.]
               7(7):57.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005014684   Laplanche, A.; Martin, G.  (1976) Contribution a la lutte contre
               les nuisances dues aux organo-phosphores: application aux eaux
               d1alimentation.   [Contribution to the control of
               organophosphorus pollutants: application to feed water.]
               Journal Francais d'Hydrologie 7(19):11-18.

000006708   Laurent, M.; Buys, M.; Sasmayoux, J.C. (1968) Phosalone: G.L.C. De-
               termination of Phosalone and 12244 R.P. in Apples and in Grape
               Extracts from the U.S.A.: D.S.Ph./D.S. An. Nord No.  12864.   (Un-
               published study received Jun 14, 1968 under 8F0668;  prepared by
               Societe des Usines Chimiques Rhone-Poulenc, submitted by Chip-
               man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-J)

000006646   Laurent, M.M. (1964) Titration of the Residues of 11974 R.P. in
               Plant Tissue: D.R.An No. 2792.  Includes method dated Sep 18,
               1963.  (English translation; unpublished study received 1965 un-
               der 359-EX-46; prepared by Societe des Usines Chimiques Rhone-
               Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth  Junction,
               N.J.; CDL:123396-G)

005005241   LeBel, G.L.; Williams, D.T.; Griffith, G.; Benoit, F.M. (1979)
               Isolation and concentration of organophosphorus pesticides from
               drinking water at the ng/L level, using macroreticular resin.
               Journal of the Association of Official Analytical Chemists
               62(2):241-249.

000006656   Lelievre, M. (1974) Phosalone—Toxicology: Data from Literature:
               S.U.C.R.P.—D.S.Ph. No. 17762.  (English translation; unpub-
               lished study received Nov 17, 1975 under 359-620; prepared by
               Societe des Usines Chimiques Rhone-Poulenc, submitted by Rhone-
               Poulenc, Inc., Monmouth Junction, N.J.; CDL:223344-F)

005013279   Leshchev, V.V.; Smirnov, A.M.; Talanov, G.A. (1974) Opredelenie
               fozalona v mede metodami tonkosloinoi i gazo-zhidkostnoi
               khromatografii.   [Determination of phosalone in honey by
               thin-layer and gas-liquid chroma tography.]  Veterinariya
               (Moscow).  [Veterinary Science.] (6):106-107.

005015528   Leshchev, V.V.; Talanov, G.A. (1976) Opredelenie FOS v  kormakh i
               produktakh.   [Determination of organophosphorus insecticides in
               feeds and animal products.]  Veterinariya (Moscow).

000006430   Lillie, D.T. (1972) Final Report: District Project No.  F 72-57.
               (Unpublished study received Mar 16, 1973 under 359-620; prepared
               by Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth
               Junction, N.J.; CDL:008914-B)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
000006747   Lillie, D.T.; Carman, G. (1971) Final Report: District Project
               No. FD 71-91.  (Unpublished study received on unknown date under
               2F1193; prepared in cooperation with Univ. of California—River-
               side, submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:
               093518-G)

000006748   Lillie, D.T.; Carman, G. (1971) Final Report: District Project
               No. FD 71-92.  (Unpublished study received on unknown date under
               2F1193; prepared by Univ. of California—Riverside, submitted by
               Rhodia, Inc., New Brunswick, N.J.; CDL:093518-H)

005008786   Lisovik, Z.A.; Gorbacheva, N.A. (1977) Gazokhromatograficheskoe
               opredelenie metafosa, metilnitrofosa i metiletiltiofosa v
               krovi.   [Gas-chromatographic determination of metaphos,
               methylnitrophos and methylethylthiophos in blood.]  Farmatsiya
               (Moscow).  [Pharmacy.] 26(5):44-51.

005011351   Makarova, S.V.; Bel'skaya, G.; Soboleva, D.A. (1972) Analiz
               ftalofosa i benzofosfata  iodometricheskim metodom.  [Analysis
               of phthalophos and benzophosphate by an iodometric titration
               method.]  Khimiya v Sel'skom Khozyaistve.  [Chemistry in
               Agriculture.] 10(5):361-362.

GS0027008   Makhijani, G.P. (1973) Memorandum sent to Bart J. Pum. Chemistry
              Branch, RD. dated May 22,  1973.  Concerns the results of method
              trial for phosalone in beef fat.  PPs ttOF0983 and  2F1193; EAPs
              #2H5013 and 2H2668.

005012298   Makhnovsky, I.K.; Kim, Z.I.; Guzeev, G.F.; Khalilov, S.  (1974)
               Ostatochnye kolichestva benzofosfata i metilnitrofosa v
               rasteniyakh i pochve.   [Residual amounts of benzophosphate and
               methylnitrophos in plants and soil.]  Lesnoe Khozyaistvo.

005018094   Malinin, O.A. (1979) Opredelenie fosfororganicheskikh pestitsidov.
               (Moscow).  [Veterinary Science.] (l):72-74.

005014948   Man'ko, N.N. (1970) Obosnovanie predel'no dopustimoi
               kontsentratsii fozalona v vozdukhe rabochei zony.   [Basis  for
               the maximum permissible concentration of phosalone  in the  air
               of a work zone.]  Gigiena Truda i Professional'nye
               Zabolevaniya.   [Labor Hygiene and Occupational Diseases.]
               14(12):46-48.

005017341   Man'ko, N.N. (1970) Toksikologiia i gigiena primeneniia  fozalona.
               Primeneniya, Toksikologiya Pestitsidov i Klinika  Ortavlenii.
               Clinical Aspects of Poisoning.] 8(2):270-277.

005013284   Man'ko, N.N.; Pis'mennaya, M.V.; Akoronko, S.L.  (1974)
               Gigienicheskie reglamenty fozalona dlia produktov pitaniia.
               Pitaniya.   [Problems of Nutrition.]  33(5):62-67.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be  Inappropriate  For Use in
                           Developing the Standard
005014951   Mandel'baum, Y.A.; Nikishova, G.E.; Nagayuk,  I.N.,  inventors;
               (1975) Sposob polucheniya dialkil-S-imidometilditiofosfatov.
               dithiophosphates.]  U.S.S.R. opisanie  izobreteniya  480,717.
               Aug 15.  2 p. Int. Cl. C 07f 9/16.

000006574   Mazuret, A. (1971) Phosalone, Methyl-azinphos and Parathion: Acute
               Percutaneous Toxicity  in the Rat: R.P.—D.S.Ph.  No.  15544.   (Un-
               published study received May 25, 1973  under 3F1337;  prepared  by
               Societe des Usines Chimiques Rhone-Poulenc,  submitted by Rhodia,
               Inc., New Brunswick, N.J.; CDL:093575-B)

005009810   McCann, J.S.; Jasper, R.LL. (1972) Vertebral  damage to  bluegills
              exposed to acutely toxic levels of pesticides.  Transactions of
              the American Fisheries  Society 101(2):317-322.

005004310   McCully, K.A.  (1972) Report on phosphated pesticides.   Journal of
               the Association of Official Analytical Chemists  55(2):291-297-

000006062   McGill, L.A. (1972) Effect of Zolone EC on the Flavor of Stone
               Fruits: Part 3.  (Unpublished study received Mar 16, 1973 under
               359-620; prepared by Oregon State Univ., Dept. of Food Science
               and Technology, submitted by Rhone-Poulenc,  Inc., Monmouth
               Junction, N.J.; CDL:096444-C)

000006587   McGill, L.A. (1972) Flavor Evaluation Report.   (Unpublished study
               received May 25, 1973  under 3F1337; prepared by  Oregon State
               Univ., Dept. of Food Science and Technology, submitted by
               Rhodia, Inc., New Brunswick, N.J.; CDL:093575-AJ)

000006433   McGill, L.A. (1972) Flavor Evaluation Report:  [Zolone].  (Unpub-
               lished study received  Mar 16, 1973 under 359-620; prepared by
               Oregon State Univ., Dept. of Food Science  and Technology, sub-
               mitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:
               008914-E)

000006432   McGill, L.A. (1973) Flavor Evaluation Report.   (Unpublished study
               received Mar 16, 1973  under 359-620; prepared by Oregon State
               Univ., Dept. of Food Science and Technology, submitted by Rhone-
               Poulenc, Inc., Monmouth Junction, N.J.; CDL:008914-D)

GS0027023   McGill, L.A. (1973) Flovor Evaluation Report.   Test Numbers S204-
              73, S206-73.   (Unpublished study concerning fresh french prunes
              treated with Zolne EC,  received Sep 24, 1973 under ?: Prepared by
              Department of Food Science and Technology,  Oregon State
              University, submitted by Rhodia, Inc.,  Chipman Division)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
GS0027022   McGill, L.A. (1973) Flavor Evaluation Report.  Test Numbers  S205,
              S243, S244-73.   (Unpublished study concerning  fresh,  canned,  and
              frozen Halford peaches treated with Zolone EC, Received Oct  5,
              1973 under ?; prepared by Department of Food Sciences and
              Technology, Oregon State University, submitted by Rhodia,  Inc.,
              Chipman Division)

000006494   McGinnis, C.H., Jr. (1974) The Effect of Dietary Phosalone on  Body
               Weight, Feed Consumption, Reproduction, and the Production  of
               Phosalone Residues in Body Tissues and Eggs of Bobwhite Quail:
               Research Report No. CHM 74:40.   (Unpublished study received
               Jun 13, 1974 under 359-620; prepared by Rhodia, Inc., submitted
               by Rhone-Poulenc, Inc, Monmouth Junction, N.J.; CDL:120351-U)

005013548   McMahon, B.; Burke, J.A. (1978) Analytical behavior data for
               chemicals determined using AOAC multiresidue methodology  for
               pesticide residues in foods.  Journal of the Association  of
               Official Analytical Chemists 61(3):640-652.

005015601   Mel'nikov, N.N. (1974) Pestitsidy i okruzhaiushchaia sreda.
               Razlozhenie fosfororganicheskikh pestitsidov.   [Pesticides  and
               the environment.  Decomposition of organophosphorus
               pesticides.]  Khimiya v Sel'skom Khozyaistve.   [Chemistry in
               Agriculture.] 12(4):289-297.

005016150   Mel'nikov, N.N. (1978) Pestitsidy v sel'skom khozyaistve v
               shveitsarii v 1978 g.   [Pesticides in agriculture in Sweden in
               1978.]  Khimiya v Sel'skom Khozyaistve.   [Chemistry  in
               Agriculture.] 16(11):19-22.

005015602   Mel'tser, F.R.; Novikova, K.F. (1970) Khromatofotometricheskiy
               metod opredeleniya ostatochnykh kolichestv fozalona  v
               rastitel'nykh pishchevykh produktakh.   [Chromatophotometric
               method for determining residual amounts of phosalone in plant
               foods.]  Khimiya v Sel'skom Khozyaistve.   [Chemistry in
               Agriculture.] 8(9):680-682.

005016359   Mel'tser, F.R.; Novikova, K.F. (1971) Novyi spetsificheskii
               kolorimetricheskii metod opredeleniya ostatochnykh kolichestv
               fozalona v rastitel'nykh ob'ektakh.   [Specific colorimetric
               determination of residual quantities of phosalone in plant
               materials. ]  Pages 295-299, I_n Trudy Vsesoyuznogo Soveshchaniya
               po Issledovaniya Ostatkov Pestitsidov i Profilaktike
               Zagryazneniya Imi Produktov Pitaniya, Kormov  i Vneshnei Sredy,
               Metody Analiza, 2nd.   [Transactions of the 2nd All-Union
               Conference on the Residues of Pesticides and  Prophylaxis  of
               Contamination by Them of Foodstuffs, Feeds and the Environment,
               Methods of Analysis.]; 1970, Tallin.  Edited  by O.M.  Tanm.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
005015598   Meltser, F.R.; Novikova, K.F. (1972) Modifikatsiia
               kolorimetricheskogo metoda opredeleniia benzofosfata v
               rastitelnykh ob'ektakh.   [Modification of the colorimetric
               method for determination of benzophosphate  (phosalone) in
               vegetable products.]  Voprosy Pitaniya.   [Problems of
               Nutrition.] 31(2):94-95.

005006261   Mestres, R.; Chevallier, C.  (1969) Residus de pesticides: XVIII.
               Technique de controle des residus de pesticides a activite
               anticholinesterasique dans les fruits et les legumes.
               residues by anticholinesterase activity in fruits and
               vegetables.]  Annales des Falsifications et de 1'Expertise
               Chimique 62(684):41-46.

005010241   Metivier, J. (1977) Synthesis of phosalone from naturally
               occurring benzoxazolones.  Pages 673-687, _In Environmental
               Pollution and Human Health: Proceedings of the International
               Symposium on Industrial Toxicology; Nov 4-7, 1975.  Edited by
               S.H. Zaidi.  Lucknow, India:  Industrial Toxicology Research
               Centre.

000006644   Metivier, M. (1964) The Assumed Metabolites of R.P. 11974: R.P.—
               D.S.Ph. No. 9552.   (English translation; unpublished study re-
               ceived 1965 under 359-EX-46; prepared by Societe des Usines Chi-
               miques Rhone-Poulenc, submitted by Rhone-Poulenc,  Inc., Monmouth
               Junction, N.J.; CDL:123396-E)

005019245   Mikami, A. (1973) Noyaku no teisei—teiryo ni kansuru hoigakuteki
               kenkyu.   [Analytical method for identification and
               determination of pesticides in forensic toxicology.]  Nippon
               Hoigaku Zasshi.   [Japanese Journal of Legal Medicine.]
               27(5):316-336.

005016361   Mikhailov, V.S.; Supin, G.S. (1971) Opredelenie ostatochnikh
               kolichestv ftalofosa i benzofosfata ostsillopolyarograficheskim
               metodom.   [Determination of residual amounts of phthalophos and
               benzophosphate by an oscillopolarographic method.]  Pages
               237-240, _In Trudy Vsesoyuznogo Soveshchaniya po Issledovaniyu
               Ostatkov Pestitsidov i Profilaktike Zagryazneniya Imi Produktov
               Pitaniya, Kormov i Vneshnei Srey, Metody Analiza,  2nd.
               of Pesticides and Prophylaxis of Contamination by Them of
               Foodstuffs, Feeds and the Environment, Methods of Analysis.];
               1970, Tallin.  Edited by O.M. Tamm.

005019336   Mirkhaitov, T.; Ikramov, L.T. (1970) Noviye kachestvenniye
               reaktsii obnaruzheniya fozalona i ftalofosa.   [New qualitative
               tests for the detection of phosalone and phthalophos.]
               Sudebno-Meditsinskaya Ekspertiza.   [Forensic Medical
               Examination.] 13(1):29-32.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005014544   Mirkhaitov, T.;  Ikramov, L.T. (1974) Ekstraktsiya fozalona i
               ftalofosa iz vodnykh rastvorov organicheskimi rastvoritelyami v
               zavistimosti ot pH sredy.  [Extraction of phosalone and
               phthalophos from aqueous solutions by organic solvents as a
               function of pH of the medium.]  Uzbekskii Khimicheskii Zhurnal.

005020254   Mitic-Muzina, N.; Adamovic, V.;  Pantovic, D.; Petrovic, 0.; Sokic,
               B. (1971) Prilog proucavanju dinamike degradacije nekih
               insekata: II.  Degradacija nekih insekticida na plodovima
               breskve i kajsije.   [A contribution to the study of the
               dynamics of the breakdown of some insecticides: II.  The
               breakdown of some insecticides in the fruits of peach and
               apricot.]  Zastita Bilja.  [Plant Protection.]
               22(112/113):51-60.

005017547   Mitic-Muzina, N.; Adamovic, X.;  Pantovic, D.; Petrovic, X.; Sokic,
               B. (1971) A contribution to the study of the degradation
               dynamics of some insecticides.  II.  Degradation of some
               insecticides on peach and apricot fruits.  Zastita Bilja.

005016279   Molozhanova, E.G.; Remizova, L.B. (1971) Opredelenie nektorikh
               fosfororganicheskikh pestitsidov v pochve pri ikh sovmestnom
               prisutstvii.   [Determination of certain organophosphorus
               pesticides with the combined presence of them.]  Pages
               177-178, ^n Trudy Vsesoyuzncgo Soveshchaniya po Issledovaniyu
               Ostatkov Pestitsidov i Profilaktike Zagryazneniya Imi Produktov
               Pitaniya, Kormov i Vneshnei Sredy, Metody Analiza, 2nd.
               of Pesticides and Prophylaxis of Contamination by Them of
               Foodstuffs, Feeds and the Environment, Methods of Analysis.];
               1970, Tallin, USSR.  Edited by O.M. Tamm.

005012644   Molozhanova, E.G.; Remizova, L.B. (1973) Metod odnovremennogo
               opredeleniya v pochve mikrokolichestv pestitsidov razlichnykh
               grupp.   [Method of simultaneous determination of
               micro-quantities of pesticides in various groups in soils.]
               Gigiena i Sanitariya.   [Hygiene and Sanitation.] 38(11) :74-75.

005007749   Murtuza, S.M.; Naqvi, S.N.H.; Ashrafi, S.H. (1971) The residual
               toxicity of Petkolin in comparison with Phosalone and DDT.
               Pakistan Journal of Scientific and Industrial Research
               14(4/5):377-379.

005001342   Nagayoshi, H.; Suzuki, K.; Kashiwa, T.  (1975) Systematic
               identification and determination of pesticides. Part 9:
               classification of 89 pesticides and related compounds by
               thin-layer chromatography.  A translation of:  Noyaku Kensasho
               Hokoku.   [Bulletin of the Agricultural Chemicals Inspection
               Station.] 15:22-30.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005015644   Nalbandyan, R.A. (1974) O sokhranenii sevina i fozalona v pochve.
               Zashchita Rastenii (Moscow).   [Plant Protection.]  (3):26.

005015594   Nalbandyan, R.A. (1975) Ostatochnyie kolichestva sevina i
               phosalona v listiakh i iagodakh vinograda.  [Residual amounts
               of.Sevin and phosalone in grapes and grape leaves.]  Khimiya v
               Sel'skom Khozyaistve.  [Chemistry in Agriculture.]
               13(9):712-713.

005014541   Nalbandyan, R.A. (1975) Vliyanie atmosfernykh osadkov va stepen1
               stabil'nosti pestitsidov.   [Effect of atmospheric precipitation
               on pesticide stability.]  Zashchita Rastenii  (Moscow).   [Plant
               Protection.]  (12):25.

000014391   Nash, R.F. (1971) Pecan and Ornamental Plant Insect and Mite Con-
               trol Studies.  (Unpublished study received Jun 26, 1974  under
               100-501; prepared by Clemson Univ., Dept. of Entomology  and Eco-
               nomic Zoology, submitted by Ciba-Geigy Corp., Greensboro, N.C.;
               CDL:094034-P)

005011355   Nazarov, S.S.; Illarionov, A.I. (1978) Toksichnost1
               fosfororganicheskikh insektitsidov dlia medonosnykh pchel.
               Khimiya v Sel'skom Khozyaistve.   [Chemistry in Agriculture.]
               16(7):61-63.

005019972   Nazarova, A.A.; Stradomskii, V.B.; Telegina, L.N. (1977)
               Issledovanie svetopogloshcheniya prircdnykh vod metodom
               UF-spektrofotometrii v tselyakh avtomatozatsii opredeleniya v
               nikh organicheskikh veshchestv.   [UV-spectrophotometric  study
               of the light absorption of natural waters for the automated
               determination of organic substances in them.]
               Gidrokhimicheskie Materialy.   [Hydrochemical Materials.]
               XLV: 102-108.

005018054   Nedkova-Bratanova, N.; Ivanov, E.; Savov, G.; Michailova, Z.;
               Krusteva, A.; Petrova, S.  (1979) Effect of the pesticides
               phosalone and lindane on the activity of some dipeptidases and
               disaccharidases in rat intestinal mucosa.  Enzyme
               24(5):281-284.

000008934   Nicholson, J.F.; Seay, R.E.; Pate, C.D.; et al.  (1975) Test Lannate
               L on Pecans for Yellow Pecan Aphid Control.   (Unpublished study
               received Sep 21, 1976 under 352-342; submitted by E.I. du Pont
               de Nemours  & Co., Wilmington,  Del.; CDL:095289-R)

000012622   Nielsen, D.G.  (1973) Phytotoxicity of Selected Insecticides on Rep-
               resentative Woody Ornamental Plants—1973.   (Unpublished study
               received May  29, 1975 under 100-501; submitted by Ciba-Geigy
               Corp., Greensboro, N.C.; CDL:115271-AD)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005015604   Nikolaishvili, A.A. (1970) Materialy o deistvii nekotorykh
               pestitsidov na britanskuyu shchitovku i eio prarsitov.   [The
               effect of some pesticides on Britannia scale and its
               predators.]  Subtropicheskie Kul'tury.  [Subtropical Crops.]
               4:174-175.

005013286   Nikulina, S.S.; Sokol'skaya, N.P. (1975) Vliyanie nekotorykh
               pestitsidov na ontogenez karpa.   [Influence of some pesticides
               on ontogenesis in carp.]  Veterinariya (Moscow).   [Veterinary
               Science.]  (7):94-95.

005012769   Novikova, K.F.; Mel'tser, F.R. (1971) Selektivnyi fotometricheskii
               metod opredeleniya mikrogrammovykh kolichestv benzofosfata.
               benzophosphate.]  Zhurnal Analiticheskoi Khimii.   [Journal of
               Analytical Chemistry.] XXVI(8):1651-1654.

005014558   Panchenko, S.E.  (1975) Stabil'nost' nekotorykh gerbitsidov  i
               insektsidov v vodnoi srede.   [Stability of some herbicides and
               insecticides  in an aqueous environment.]  Pages
               96-98, In Mekhanizm Deistviya Gerbitsidov i Sinteticheskikh
               Regulyatorov Rosta Rastenii Ikh Sud'ba v Biosfere, Materialy
               Mezhdunarodnogo Simpoziuma Stran-Chlenov SEV, 10th.   [Mechanism
               of Action of Herbicides and Synthetic Plant Growth Regulators
               and their Ultimate Fate in Biosphere, Materials of the 10th
               International Symposium of Member Countries of the Council for
               Mutual Economic Assistance.]; Apr 15-17, Pushchino, USSR.  Vol.
               2.  Edited by M.S. Sokolov.  Pushchino, USSR:  Akademiya Nauk
               SSSR, Nauchnyi Tsentr Biologicheskikh Issledovanii.

000006295   Pasquet, J.; Mazuret, A.  (1973) Phosalone Oxygen-Analog  (12244
               R.P.): Acute  Percutaneous Toxicity in the Rat: S.U.C.R.P.—
               D.S.Ph. No. 16979.   (Unpublished study received Mar 4, 1976
               under 6F1753; prepared by Societe des Usines Chimiques Rhone-
               Poulenc, submitted by Rhodia, Inc., Monmouth Junction, N.J.;
               CDL:095979-K)

005014815   Pavlova, G.A. (1975) Stetorus—khishchnik pautinnogo kleshcha.
               (Moscow).   [Plant Protection.] (1):23-24.

005015596   Pierrard, G.  (1971) Effet de 1'utilisation de la phosalone  sur la
               qualite de la fibre de coton.   [The effect of phosalone  usage
               on cotton fiber quality.]  Mededelingen van de Faculteit
               Landbouwwetenschappen, Rijksuniversiteit Gent.   [Communications
               of the Faculty of Agricultural Sciences, State University of
               Ghent.] 36(1):294-299.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate  For Use  in
                           Developing the Standard
005017545   Pis'mennaya, M.V.; Klisenko, M.A.  (1969) Opredelenie  ftalofoza,
               fozalona, fenkaptona, tsidiala metodom tonkosloinoi
               khroraatografii v produktakh rastitel'nogo proiskhozbdeniya.
               phosalone, phencapton and cidial  in plant products.]  Gigiena
               Primeneniya Toksikologiya Pestitsidov i Klinika Otravlenii.
               Clinical Aspects of Poisoning.] 7:591-595.

005016596   Pis'mennaya, M.V.; Klisenko, M.A.  (1972) Tonkosloynaya
               khromatografiya ostatochnykh kolichestv novykh
               fosfororganicheskikh pestitsidov.   [Thin layer chromatography
               of residual amounts of new organophosphorus pesticides.]
               Problemy Analiticheskoi Khimii.   [Problems of Analytical
               Chemistry.] 2:111-115.

000008886   Poe, S.L. (1973) The Tomato Pinworm  in Florida: Bradenton AREC Re-
               search Report GC1973-2.   (Unpublished study received Dec 20,
               1974 under 352-342; prepared by Univ. of Florida,  Institute of
               Food and Agricultural Sciences, Agricultural Research and Educa-
               tion Center, submitted by E.I. du Pont de Nemours  & Co.; CDL:
               022993-D)

000011418   Pollet, O.K.  (1975) Pecan Demonstration Orchard Treatments, 1975.
                (Unpublished study including letter dated Dec 17,  1976  from O.K.
               Pollet and J.B. Aitken to Steve Dumford, received  Dec 22, 1977
               under 100-501; prepared by Clemson Univ., Cooperative Extension
               Service, Dept. of Entomology, submitted by Ciba-Geigy Corp.,
               Greensboro, N.C.; CDL:232600-G)

GS0027018   Popendorf, W. (1980) Exploring citrus harvesters' exposure to
              pesticides contaminated foliar dust.  Am. Ind. Hyg. Assoc. J. 41:

000006792   Posner, S.  (1971) Cow-Feeding Study  with Phosalone  (Technical)
               Insecticide  (Dairy Cattle)—Biological Phase.   (Unpublished
               study including letter dated Jul  26, 1971 from L.C. Brown to
               Lee E. TerBush, received  Jun 13,  1974 under  359-620; prepared by
               Biometric Testing, Inc.  for Rhodia,  Inc., submitted by  Rhone-
               Poulenc, Inc., Monmouth  Junction, N.J.; CDL:120351-T)

000006761   Posner, S.  (1971) Cow-Feeding Study  with Phosalone  (Technical)
               Insecticide  (Dairy Cattle)—Biological Phase.   (Unpublished
               study including project  no. 49-181,  received Jun  26,  1972 under
               OF0983; prepared in cooperation with Biometric Testing,  Inc.,
               submitted by Rhodia,  Inc., New Brunswick, N.J.; CDL:091691-C)

000006630   Preiser, F.A.; Glass, E.H.  (1968) Report No. BB 68-86.   (Unpub-
               lished study received Dec 22, 1969 under 359-626;  prepared  in
               cooperation with Cornell  Univ., submitted by Rhone-Poulenc,
               Inc., Monmouth Junction,  N.J.; CDL:003174-H)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
000006600   Preiser, F.A.; Semel, M. (1966) Zolone EC—Potatoes: Final Report
               No. BB 66-120.  (Unpublished study received Dec 7, 1972 under
               3F1337; prepared in cooperation with Cornell Univ., submitted
               by Rhodia, Inc., New Brunswick, N.J.; CDL:094849-V)

000006479   Preiser, F.A.; Taschenberg, E.F.  (1968) Report No. BB 68-91.   (Un-
               published study received Nov 18, 1971 under 359-626; prepared
               in cooperation with Cornell Univ., submitted by Rhone-Poulenc,
               Inc., Monmouth Junction, N.J.; CDL:003175-T)

005017308   Prishchepa, I.A. (1974) Vliianie  insektitsidno-gerbitsidnykh
               smesei na napravlennost1 uglevodnogo obmena v rasteniiakh
               iachmenia.   [Effect of insecticide-herbicidal mixtures on the
               direction of carbohydrate metabolism in barley plants.]  Pages
               82-84, _In Aktual'nye Voprosy Zashchity Rastenii v BSSR,
               Materialy Respublikanskoi Konferentsii Molodykh Uchenykh, 1st.
               Materials of the 1st Republic Conference of Young Scientists.];
               1974, Minsk, USSR.  Edited by A.L. Ambrosov and V.V. Nikolaeva.
               Minsk, USSR:  Belorusskii Nauchno-Issledovatel'skii Institut
               Zemledeliya.

005017487   Prishchepa, I.A.; Samersov, V.F.  (1978) Deistvie
               ger'ididno-insektididnykh smesei na uri raziykh urovnyakh
               pitaniya.   [Effect of herbicide-insecticide mixtures on the
               yield of barley grain at different nutritional levels.]
               Agrokhimiya.  [Agricultural Chemistry.] (10):117-121.

005012768   Pristavko, V.P.; Degtyarev, B.C.; Chaika, V.N. (1976)
               Elektrofiziologicheskaya reaktsiya obonyaniya yablonnoi
               plodozhorki Laspeyresia pomonella L. kak vozmozhpyi
               ekspress-metod opredeleniya toksichnosti i soderzhaniya
               insektitsidov.  [Electrophysiological reaction of the sense of
               smell of the lesser apple worm Laspeyresia pomonella L. as a
               possible quick test for determining toxicity and content of
               insecticides.]  Doklady Akademii Nauk SSSR.  [Proceedings of
               the Academy of Sciences of the USSR.] 228(4):999-1000.

005014277   Pruszynski, S.; Cone, W.W. (1972) Relationships
               between Phytoseiulus persimilis and other enemies of the
               twospotted spider mite on hops.  Environmental Entomology
               1(4):431-433.

005015536   Pruszynski, S.; Cone, W.W. (1973) Biological observations
               of Typhlodromus occidentalis (Acarina: Phytoseiidae) on hops.
               Annals of the Entomological Society of America 66(1):47-51.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate  For Use  in
                           Developing the Standard
005013281   Pujman, V. (1972) Zmeny krevniho obrazu bazantu po podani
               nekterych pesticid.  [Blood picture changes in pheasants
               following the administration of some pesticides.]  [abstract].
               Ceskoslovenska Fysiologie.   [Czechoslovak Physiology.]
               21(4):380.

005017094   Pulatov, B.A.; Antonovich, E.A. (1975) Vliyanie nekotorykh
               fosfororganicheskikh pestitsidov  i gerbitsidov na  khimicheskii
               sostav i pitatel'nuyu tsennost1 sel'skokhozyaistvennykh
               kul'tur.  [Effect of some organophosphorous pesticides and
               herbicides on the chemical composition and nutritional value of
               agricultural crops.]  Meditsinskii Zhurnal Uzbekistana 9:44-46.

005008144   Rajukkannu, K.; Saivaraj, K.; Vasudevan, P.; Balasubramanian, M.
               (1978) Residues of methyl parathion, quinalphos, phosalone and
               fenitrothion in/on okra  [letter].  Current Science
               47(20):782-783.

005009336   Rashid, S.; Roohi, R.A.; Naqvi, S.N.H. (1973) Characterization of
               acid phosphatase and its relation with insecticide metabolism
               in Bruchus chinensis (Linnaeus).  Pages
               209-218, In Environmental Quality and Safety.  Vol.  2.  New
               York:  Academic Press.

005014546   Rasulev, B.D.; Tashbekov, T.U.  (1972) Pestitsidy, mineral'nye
               udobreniya, i kachestvo plodov yabloni.   [Pesticides, mineral
               fertilizers, and the quality of apples.]  Meditsinskii Zhurnal
               Uzbekistana.   [Medical Journal of Uzbekistan.] (5):24-26.

000006493   Rausina, G. (1974) Report to Rhodia, Inc., Chipman Division: Four-
               Day Static Aquatic Toxicity study with Zolone EC in  Shore Crabs:
               IBT No. 621-04483.  (Unpublished study received Jun  13, 1974
               under 359-620; prepared by Industrial Bio-Test Laboratories,
               Inc. for Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Mon-
               mouth Junction, N.J.; CDL:120351-S)

000006492   Rausina, G. (1974) Report to Rhodia, Inc., Chipman Division: Four-
               Day Static Aquatic Toxicity Study with Zolone EC in  Brown
               Shrimp, February 15, 1974: IBT No. 621-04483.  (Unpublished
               study received Jun 13, 1974 under 359-620; prepared  by Indus-
               trial Bio-Test Laboratories, Inc., submitted by Rhone-Poulenc,
               Inc., Monmouth Junction, N.J.; CDL:120351-R)

000006933   Reed, L.R. (1964) Summary & Review Report: Residue Sampling Pro-
               gram for New Pesticides.  (Unpublished study received
               Apr 17, 1964 under 7G0575; submitted by Chipman Chemical Co.,
               Inc., Burlingame, Calif.; CDL:090736-CU)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
000006692   Reed, L.R. (1966) Insecticide—Phosalone—RP11974: SR/4/66.   (Eng-
               lish translation of report no. 688; unpublished study received
               Dec 15, 1966 under 7G0575; prepared by Rhone-Poulenc,  Inc.  in
               cooperation with Centre Technique Interprofessionnel  des  Olea—
               gineax Metropolitains, I.N.T.A., Bee Station and Univ. of Cali-
               fornia—Riverside, submitted by Chipman Chemical Co.,  Inc.,  Bur-
               lingame, Calif.; CDL:090729-G)

005011159   Renvall, S. (1977) Insektsmedel i bin och honung.   [Insecticides
               in bees and honey.]  Vaxtskyddsnotiser.   [Notes on  Plant
               Protection.] 41(3):77-79.

GS0027026   Rhodia, Incorporated, Chipman Division (19??).  The Results  of
              Tests on the Amount of Phosalone Reisudes  Remaining  in or  on
              Artichokes.  Including a Description of the Analytical Method
              Used.  Test Numbers 100472-036, 100471-035, 100471-036.  Report
              2733, 2734, 170473-050.   (Unpublished study received ? under
              3E1401)

000006659   Rhodia, Incorporated  (19??)  [Toxicity to Bees].   (pp.  5,8 only; un-
               published study received Nov 17, 1975 under 359-620;  submitted
               by Rhone-Poulenc,  Inc., Monmouth Junction, N.J.; CDL:223344-M)

000006736   Rhodia, Incorporated  (19??) Analytical Methods.   (Unpublished study
               received Jun 8, 1973 under 3H5038; CDL:221773-1)

000006108   Rhodia, Incorporated  (19??) Contents Summary Statements.  Summary
               of studies 095979-H through 095979-M.  (Unpublished study re-
               ceived Mar 4, 1976 under 6F1753; CDL:095979-G)

000006072   Rhodia, Incorporated  (19??) Oxygen Analog of Phosalone,  R.P.  12244.
               (Unpublished study received Oct 16, 1967  under 9F0759; CDL:
               093071-H)

000006120   Rhodia, Incorporated  (19??) Phosalone in Dairy Cattle  Tissue: Sum-
               mary.  (Unpublished study received May 6, 1970 under  OF0983;
               CDL:093292-G)

000006173   Rhodia, Incorporated  (19??) Summary: Zolone  WP Residue—Grapes.
               (Unpublished study received 1971 under 359-626; submitted by
               Rhone-Poulenc, Inc., Monmouth Junction, N.J.;  CDL:122862-A)

000006106   Rhodia, Incorporated  (19??) Technical Data Sheet.   (Unpublished
               study received Mar 4, 1976 under 6F1753;  CDL:095979-C)

000006239   Rhodia, Incorporated  (1964) Final Report: Tart Cherries:  Report
               No. C 64-24.  (Unpublished study received Mar  26, 1971 under
               1F1155; CDL:093474-G)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
000006589   Rhodia, Incorporated (1966) Phosalone—Potato Petition.  Summary of
               studies 093575-B through 093575-D.  (Unpublished study received
               May 25, 1973 under 3F1337; CDL:093575-AL)

000006515   Rhodia, Incorporated (1966) Zolone EC: Grapefruit.  Summary of
               studies 092026-BC and 092026-BE.   (Unpublished study received
               Feb 16, 1970 under OF0948; CDL:092026-D)

000006516   Rhodia, Incorporated (1966) Zolone EC: Lemons.  Summary of studies
               092026-BD and 092026-BF.   (Unpublished study received Feb  16,
               1970 under OF0948; CDL:092026-E)

000006712   Rhodia, Incorporated (1967) Field and Analytical Data: Phosalone
               Residue in Apples—Ontario, Canada—1967.   (Unpublished study
               received Jun 14, 1968 under 8F0668; submitted by Chipman Chemi-
               cal Co., Inc., Burlingame, Calif.; CDL:091171-X)

000006717   Rhodia, Incorporated (1967) Phosalone Feeding Test.   (Unpublished
               study received Jun 14, 1968 under 8F0668; prepared  in coopera-
               tion with Woodard Research Corp., submitted by Chipman Chemical
               Co., Inc., Burlingame, Calif.; CDL:091171-AM)

000006123   Rhodia, Incorporated (1967) Summary: Analysis of Phosalone (RP
               11974) Residue in Tissues of Beef Cattle and Sheep.   (Unpub-
               lished study received May  6, 1970 under OF0983; CDL:093292-J)

000006080   Rhodia, Incorporated (1968) Apples—Phosalone.   (Unpublished  study
               received Sep 12, 1968 under 9F0759; CDL:091306-G)

000006081   Rhodia, Incorporated (1968) Pears—Phosalone.   (Unpublished study
               received Sep 12, 1968 under 9F0759; CDL:091306-H)

000006122   Rhodia, Incorporated (1968) Reasonable Grounds in Support of  the
               Petition:  [Phosalone].   (Unpublished study received May 6, 1970
               under OF0983; CDL:093292-1)

000006704   Rhodia, Incorporated (1968) Residue Data Requirements:  [Phosalone].
               Summary of studies 091171-F through 091171-M.   (Unpublished
               study received Jun 14, 1968 under 8F0668; submitted by Chipman
               Chemical Co., Inc., Burlingame, Calif.; CDL:091171-E)

000006201   Rhodia, Incorporated (1969?) Stone Fruit Petition:  [Phosalone].
               (Unpublished study received Mar 26, 1971 under 1F1155; CDL:
               093475-P)

000006513   Rhodia, Incorporated (1969) Zolone EC: Pecans.  Summary of studies
               092026-S through 092026-AB.  (Unpublished study received Feb 16,
               1970 under OF0948; CDL:092026-B)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
000006199   Rhodia, Incorporated (1969) Zolone EC: Product Number 300.   (Unpub-
               lished study received Mar 26, 1971 under 1F1155; CDL:093475-1)

000006200   Rhodia, Incorporated (1969) Zolone WP: PN 304.   (Unpublished  study
               received Mar 26, 1971 under 1F1155; CDL:093475-L)

000006194   Rhodia, Incorporated (1970) Apricots:  [Phosalone].   (Unpublished
               study received Mar 26, 1971 under 1F1155; CDL:093475-A)

000006195   Rhodia, Incorporated (1970) Cherries:  [Phosalone].   (Unpublished
               study received Mar 26, 1971 under 1F1155; CDL:093475-B)

000006196   Rhodia, Incorporated (1970) Nectarines:  [Phosalone].  (Unpublished
               study received Mar 26, 1971 under 1F1155; CDL:093475-C)

000006197   Rhodia, Incorporated (1970) Peaches:  [Phosalone].   (Unpublished
               study received Mar 26, 1971 under 1F1155; CDL:093475-D)

000006198   Rhodia, Incorporated (1970) Prunes:  [Phosalone].   (Unpublished
               study received Mar 26, 1971 under 1F1155; CDL:093475-E)

000006382   Rhodia, Incorporated (1970) Zolone EC: Apricots.   Summary of  stud-
               ies 093474-BI through 093474-BQ.   (Unpublished  study  received
               May 6, 1970 under OF0983; CDL:091692-AE)

000006381   Rhodia, Incorporated (1970) Zolone EC: Peaches.   Summary of studies
               093474-N through 093474-R.   (Unpublished study  received May  6,
               1970 under OF0983; CDL:091692-AC)

000006238   Rhodia, Incorporated (1970) Zolone EC: Prunes.   Summary  of studies
               093474-AS through 093474-BH and 093474-BR.   (Unpublished study
               received Mar 26, 1971 under 1F1155; CDL:093474-F)

000006577   Rhodia, Incorporated (1971?) Reasonable Grounds  in Support of the
               Petition:  [Zolone].   (Unpublished  study received May  25, 1973
               under 3F1337; CDL:093575-R)

000006210   Rhodia, Incorporated (1971) Phosalone—Tea: Phosalone Residue Stud-
               ies.  (Unpublished study including  letters dated Jul  19,  1972
               from J. Metivier and P. Petrinko to Tea Research Association and
               Aug 1, 1972 from B. Banerjec to Societe des Usines Chimiques
               Rhone-Poulenc, received Jun 8, 1973 under  3H5038; prepared in
               cooperation with Tea Research Association and United  Planters
               Association of Southern India; CDL:221773-B)

000006591   Rhodia, Incorporated (1971) Potatoes:  Phytotoxicity Summary.  Sum-
               mary of studies 094849-D, 094849-E, 094849-AB,  094849-AI,
               094849-AO, 094849-AR, 094849-AT and 094849-AW.   (Unpublished
               study received Dec 7, 1972 under  3F1337; CDL:094849-C)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be  Inappropriate  For Use in
                           Developing the Standard
000006510   Rhodia, Incorporated  (1971) Zolone EC:  Pecans.   Summary of  studies
               091617-L through 091617-X.   (Unpublished  study  received  on un-
               known date under OF0948; CDL:091617-A)

000006357   Rhodia, Incorporated  (1972?) Phosalone  Dried Apple Pomace Data.
               Includes undated method.   (Unpublished  study  received Jun  26,
               1972 under OF0983; prepared  in cooperation with Cornell  Univ.,
               New York State Agricultural  Experiment  Station,  Dept. of Food
               Science and Technology; CDL:091691-A)

000006733   Rhodia, Incorporated  (1972) Effect of Zolone EC  on Stone Fruits;
               Phytotoxicity: Part  1.   (Unpublished study including district
               project nos. F 72-62, F 72-63, Port  72-27, Port 72-32 and  Port
               72-41, received Mar  16, 1973 under 359-620; submitted by Rhone-
               Poulenc, Inc., Monmouth Junction, N.J.; CDL:096444-A)

000006091   Rhodia, Incorporated  (1972) Efficacy Data  Summary:  [Zolone].   Sum-
               mary of studies 093518-M through 093518-AB.   (Unpublished  study
               received on unknown  date under 2F1193;  CDL:093518-L)

000006578   Rhodia, Incorporated  (1972) Zolone EC—Potatoes.   Summary of  stud-
               ies 093575-X through 093575-AI.  (Unpublished study  received
               May 25, 1973 under 3F1337; CDL:093575-S)

000006594   Rhodia, Incorporated  (1972) Zolone EC:  Potatoes.   Summary of  stud-
               ies 094849-P, 094849-Q, and  094849-S through  094849-AW.   (Unpub-
               lished study received Dec 7, 1972 under 3F1337;  CDL:094849-G)

000006061   Rhodia, Incorporated  (1973) Effect of Zolone EC  on Yield and  Qual-
               ity of Stone Fruits: Part  2.   (Unpublished study including
               letters dated Jan  4, 1973  from F.R.  Hall  to Julius Szabo;  Jun
               30, 1972 from S.C. Jones to  Everett  P.  Smyth; Aug 25, 1972 from
               J.B. Curtis to D.I.  Wang; Nov 17, 1972  from G.R. Garner  to
               Harold D. Knobel;  Aug 23,  1972 from  J.C.  Taylor to Jim Bone;
               Aug 31, 1972 from  R. Brown to D.I. Wang;  July 10, 1972 from G.R.
               Post to E. Lillie; Jul 3,  1972 from  R.E.  Rice to D.T. Lillie;
               Jul 12, 1972 from  J.E. Dibble to D.T.  Lillie; Sep 11, 1972 from
               A.D. Saso to Der I Wang; Aug 24, 1972  from R.J. Franklin to Dr.
               Wang, and Jan 18,  1973 from  A.J. Howitt to Julius G. Szabo, re-
               ceived Mar 16, 1973  under  359-620; submitted  by Rhone-Poulenc,
               Inc., Monmouth Junction, N.J.; CDL:096444-B)

000006112   Rhodia, Incorporated  (1974?)  Zolone—Alflafa [sic]: Reasonable
               Grounds in Support of the  Petition.   (Unpublished study  received
               Mar 4, 1976 under  6F1753;  CDL:095979-N)

000006488   Rhodia, Incorporated  (1974) Environmental  Impact Studies for Phosa-
               lone.  (Unpublished  study  including  PR notice 70-15, received
               Jun 13, 1974 under 359-620;  submitted  by  Rhone-Poulenc,  Inc.,
               Monmouth Junction, N.J.; CDL:120351-A)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
000006148   Rhodia, Incorporated (1974) Zolone—Carrot: Quarterly Report  Ending
               August 22, 1974.  (Unpublished study received Sep 24, 1974 under
               359-EX-52; submitted by Rhone-Poulenc, Inc., Monmouth Junction,
               N.J.; CDL:225864-A)

000006965   Rhodia, Incorporated (1975?) Content Summary Statements.  Summary
               of studies 098088-B through 098088-P and 098088-T through
               098088-Y.  (Unpublished study received Mar 4, 1976 under 6F1753;
               CDL:098088-A)

000006168   Rhodia, Incorporated (1975) Summary Report on the Zolone-Carrot Ex-
               perimental Use Program for the Period May 22, 1974 to May  21,
               1975.  (Unpublished study received Jul 1, 1975 under 359-EX-52;
               submitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:
               225861-A)

000006662   Rhodia, Incorporated (1977?) Introduction:  [Phosalone].  Summary of
               studies 229759-B through 229759-J.  (Unpublished study received
               May 10, 1977 under 359-620; submitted by Rhone-Poulenc, Inc.,
               Monmouth Junction, N.J.; CDL:229759-A)

000006489   Rhone-Poulenc, Incorporated (1967) Toxicity to Bees.  Summary of
               studies 120351-G through 120351-1.  (Unpublished study received
               Jun 13, 1974 under 359-620; prepared in cooperation with Wash-
               ington State Univ. and Univ. of California, Agricultural Exten-
               sion Service; CDL:120351-F)

000006782   Rhone-Poulenc, Incorporated (1969) Zolone WP Formulation: Apples.
               Summary of studies 003174-A through 003174-T.  (Unpublished
               study received Dec 22, 1969 under 359-626; CDL:003174-V)

005015300   Richard, Y.; Brener, L.  (1978) Organic materials produced upon
               ozonization of water.  Pages 169-188, In Ozone/Chlorine Dioxide
               Oxidation Products of Organic Materials, Proceedings of a
               Conference; Nov 17-19, 1976, Cincinnati, Ohio.  Edited by  R.G.
               Rice and J.A. Cotruvo.  Cleveland, Ohio:  Ozone Press
               International.

005012670   Rovinskii, F.Y.; Gasilina, N.K. (1978) Problemy analiza pri
               kontrole zagryazneniya okruzhayushchei sredy.   [Analytical
               problems in monitoring environmental pollution.]  Zhurnal
               Analiticheskoi Khimii.   [Journal of Analytical Chemistry.]
               XXXIII(1):160-170.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005016978   Sabirova, D.U.; Bobyreva, T.V. (1974) Vliyaniye fozalona i
               ftalofosa na khishchnika pautinnogo kleshcha Stethorus
               on Stethorus punctillum Ws., a predator of the spider mite.]
               Pages 138-139, JEn Materialy S'ezda Vsesoyuznogo
               Entomologicheskogo Obshchestva, 7th.   [Materials of the 7th
               Congress of the Ail-Union Entomological Society.]; 1974,
               Leningrad, USSR.  Vol. 2.  Edited by I.M. Kerzhner.  Leningrad,
               USSR:  Akademiya Nauk SSSR, Zoologicheskii Institut.

005006146   Safonov, N.M. (1968) Toksikologicheskaya kharakteristika novogo
               fosfororganicheskogo insektitsida fozalona.  [Toxicological
               characteristics of the new organophosphorus insecticide
               phosalone; preliminary data.]  Gigiena Truda i Professional'nye
               Zabolevaniya.   [Labor Hygiene and Occupational Diseases.]
               12(12):43-44.

005014686   Sagredos, A.N.; Eckert, W.R.  (1976) Methoden zur Bestimmung von
               Phytopharmaka in Tabak und Tabakerzeugnissen.  II.  Mitteilung:
               Zur Simultanbestimmung von hexanloeslichen
               Organophosphor-Pflanzenschutzmitteln.   [Methods for the
               determination of phytopharmaceuticals  in tobacco and tobacco
               products.  Part II.  Simultaneous determination of
               hexane-soluble organophosphorus pesticides.]  Beitraege zur
               Tabakforschung 8(7):447-454.

005015603   Samersov, V.F.; Prishchepa, I.A.  (1976) Insektitsidno-gerbitsidnye
               smesi dlya zashity yachmenya.   [Insecticide-herbicide mixtures
               for protecting barley.]  Khimiya v Sel'skom Khozyaistve.

005011353   Samersov, V.F.; Prishchepa, I.A.  (1978) Vliyanie
               gerbitsidno-insektotsidnykh smesei na  soderzhanie azotistykh
               seshchestv v rasteniyakh iachmenia.   [Effect of
               herbicide-insecticide mixtures on the  level of nitrogenous
               substances in barley plants.]  Khimiya v Sel'skom Khozyaistve.

000006128   Schafer, C.A.; Stier, E.F.  (1974) Sensory Evaluation Report on
               Carrot.  (Unpublished study received Feb 12, 1974 under  4E1468;
               prepared in cooperation with Rutgers Univ., Dapt. of Food
               Science, submitted by Interregional Research Project No. 4, New
               Brunswick, N.J.; CDL:093909-1)

000006694   Scott, W.J.; Beliles, R.P.  (1966) Phosalone:  Potentiation Studies
               in the Rat with Marketed Pesticides: Addendum.   (Unpublished
               study received Dec 15, 1966 under 7G0575;  prepared by Wbcdard
               Research Corp., submitted  by Chipman Chemical Co., Inc., Bur-
               lingame, Calif.; CDL:090729-J)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
OC5016280   Sedykh, A.S.; Abelentseva, G.M.; Ivanova, G.B. (1971)
               Chuvstvitel'nost1 biologicheskogo i
               tonkosloyno-khromatograficheskogo metodov opredeleniya ostatkov
               pestitsidov.  [Sensitivity of biological and thin-layer
               chromatographic methods of determining pesticide residues.]
               Pages 277-278, In Proceedings of the 13th International
               Congress of Entomology; Aug 2-9, 1968, Moscow.  Vol. 2.  Edited
               by G.Y. Bei-Bienko.

005016022   Sedykh, A.S.; Popov, P.V.; Abelentseva, G.M.; Shapovalova, G.K.;
               Ivanova, G.B. (1972) Chuvstvitel'nost1 biologicheskogo i
               tonkosloinokhromatograficheskogo metodov opredeleniya ostatkov
               pestitsidov.  [Sensitivity of biological and thin-layer
               chromatographic methods of determining pesticide residues.]
               Problemy Analiticheskoi Khimii.  [Problems of Analytical
               Chemistry.] 2:130-135.

005015382   Semenova, S.A.; Golubeva, Z.Z.; Siforova, T.A. (1967) Toksichnost'
               nekotorykh fosfororganicheskikh insectoakaritsidov dlya
               pautinnogo kleshcha i poleznykh nasekomykh.   [Toxicity of some
               organophosphorus acaricides for spider mites and useful
               insects.]  Khimiya v Sel'skom Khozyaistve.  [Chemistry in
               Agriculture.] 5(12):61.

005007625   Serat, W.F.; Bailey, J.B. (1974) Estimating the relative
               toxicologic potential of each pesticide in a mixture of
               residues on foliage.  Bulletin of Environmental Contamination
               and Toxicology 12(6):682-686.

005013283   Shakhsuvarian, N.V. (1972) Vliianie zolona na rasteniia
               khlopchatnika pri maloob'emnom opryskanii.  [Effect of Zolone
               on cotton plants during low-volume spraying„]   Khimiya v
               Sel'skom Khozyaistve.  [Chemistry in Agriculture.]
               10(4):282-283.

005013282   Shakhsuvarian, N.V.; Stepanov, F.A. (1974) Vliianie benzofosfata i
               gardony na nekotorye fiziologi-biokhimicheskie protsessy v
               rasteniiakh khlopchatnika pri maloob'emnom opryskanii.   [Effect
               of benzophosphate and Gardona on certain physiological and
               biochemical processes  in cotton plants during low-volume
               spraying.]  Khimiya v  Sel'skom Khozyaistve.   [Chemistry in
               Agriculture.] 12(8):588-589.

005013871   Shapovalova, G.K.; Galitsina, V.V.  (1973) Vliyanie vodorastvorimoi
               plenki na insektitsidnost' benzofosfata.   [The effect of a
               water soluble film on  the insecticidal activity of
               benzophosphate.]  Khimiya v Sel'skom Khozyaistve.   [Chemistry
               in Agriculture.] 11(2):117.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
005015597
005018184
005010412
005014276
005014465
005014822
005019956
000006243
000006639
Shapovalova, G.K.; Sedykh, A.S.; Abelentseva, G.M.  (1970) Ob
   effektivnosti primeneniia ftalofosa i benzofosfata protiv
   kryzhovnikovoi ognevki i ostatkakh insektitsidov na iagodakh.
   combat gooseberry moth ( Zophodia convolutella  ), and
   insecticide residues on the berries.]  Khimiya v Sel'skom
   Khozyaistve.  [Chemistry in Agriculture.] 8(8):594-595.

Sharashidze, O.V.; Bakanidze, M.S.  (1975) Vliyanie razlichnykh
   fosfororganicheskikh preparatov na fiziologo-biokhimicheskie
   protessy chainogo rasteniya i na kachestvo gotovoi produktsii
   chaya.   [Effect of various organophosphorus preparations on the
   physiological-biochemical processes of tea plants and on the
   quality of prepared tea products.]  Subtropicheskie Kul'tury.

Shaw, F.R.; Callahan, R.A.; Miller, M.C. (1966) Rates of
   disappearance of Zolone and Imidan from alfalfa.  Journal of
   Economic Entomology 59(6):1524-1525.

Shinde, V.P.; Gatlewar, W.N.; Sansare, G.M.; Ramachandran, K.;
   Athlekar, S.V.; Mhatre, N. (1978) Evaluation of tolerability of
   phosalone (Zolone) 35% EC, an organophosphatic  insecticide, by
   human beings exposed to aerial spray under Indian field
   conditions—part I.  Pesticides 12(8):23-34,36.

Shoyama, M. (1977) Hakuso oyobi gasu kuromatografui ni yoru
   satchuzai no ensoku na dotei no tame n& benzokuho.
   insecticides by thin-layer and gas chromatography.]  Bunseki
   Kagaku.  [Japan Analyst.] 26(7):499-502.

Shoyama, M.; Miyachi, Y.; Sakakibara, J. (1976) Enka palladium to
   p-nitroso N,N-diethylaniline wo riyo shita ganiwo yuki rinkei
   sacchuzai no hishoku teiryo.   [Colorimetric determination of
   organothiophosphorus pesticides with palladium chloride and
   p-nitroso N,N-diethylaniline.]  Bunseki Kagaku.   [Japan
   Analyst.] 25(3):179-182.

Singh, B.; Dhaliwai, G.S.; Kalra, R.L.  (1980) Residues of
   quinalphos and phosalone in tomato.  Bulletin of Environmental
   Contamination and Toxicology 24(3):423-426.

Smyth, E.P.; Burkhart, D.; McCollister, E.G. (1969) Final Report:
   District Project No. Port 69-19.  (Unpublished study received
   Mar 26, 1971 under 1F1155; submitted by Rhodia, Inc., New Bruns-
   wick, N.J.; CDL:093474-L)

Smyth, E.P.; Hoyt, S. (1969) Summary Report: District Project
   No. Port 69-40.   (Unpublished study received Dec 22, 1969 under
   359-626; submitted by  Rhone-Poulenc, Inc., Monmouth Junction,
   N.J.; CDL:003174-Q)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
000006283   Smyth, E.P.; Jones, S.C. (1970) Final Report: District Project
               No. Port 70-22.  (Unpublished study received Mar 26,  1971 under
               1F1155; prepared in cooperation with Oregon State Univ., Ento-
               mology Dept., submitted by Rhodia, Inc., New Brunswick, N.J.;
               CDL:093474-BD)

000006858   Smyth, E.P.; Westigard, P. (1967) Report No. Port 67-24.   (Unpub-
               lished study received Jul 5, 1968 under 8F0668; submitted by
               Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:092027-BV)

000006641   Societe des Usines Chimiques Rhone-Poulenc (1963) General Charac-
               teristics and Properties of Phosalone (R.P. 11974).   Summary of
               studies 123396-B through 123396-K.  (English translation; unpub-
               lished study received 1965 under 359-EX-46; submitted by Rhone-
               Poulenc, Inc., Monmouth Junction, N.J.; CDL:123396-A)

000006396   Societe des Usines Chimiques Rhone-Poulenc (1966) Phosalone: Data
               for the U.S. Public Health Department: R.P.—D.S.Ph.  No. 11340.
               (Unpublished study received Feb 2, 1967 under 7G0575; submitted
               by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090727-P)

000006676   Societe des Usines Chimiques Rhone-Poulenc (1968) Phosalone and
               Oxygen-Analog  (12244 R.P.): Residues in Apples, Pears and
               Grapes: R.P.—D.S.Ph. No. 12646.  (Unpublished study  received
               Jun 14, 1968 under 8F0668; submitted by Chipman Chemical Co.,
               Inc-., Burlingame, Calif.; CDL:091170-D)

000006674   Societe des Usines Chimiques Rhone-Poulenc (1968) 12244  R.P.:
               Oxygen Analog of Phosalone: Acute Oral Toxicity and Anticho-
               linesterasic Activity in Vitro: R.P.—D.S.Ph. No. 12644.   (Un-
               published study received Jun 14, 1968 under 8F0668; submitted by
               Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:091170-B)

005018191   Specht, W. (1978) Methode zur raschen Aufarbeitung groesserer
               Fettmengen fuer die Analyse von Pestizidrueckstaenden.   [Quick
               method for processing sizeable quantities of fat for  the
               analysis of pesticide residues.]  Mitteilungsblatt der
               GDCh-Fachgruppe Lebensmittelchemie und Gerichtliche Chemie
               32(3):51-53.

005008228   Spehar, R.L.; Holcombe, G.W.; Carlson, R.W.; Drummond, R.A. ;
               Yount, J.D.; Pickering, Q.H.  (1979) Effects of pollution on
               freshwater fish.  Journal of the Water Pollution Control
               Federation 51(6):1616-1694.

000006738   Spencer, W.T.; Hofmaster, R.N. (1974) Final Report: District
               Project No. 314574-011.  (Unpublished study received  May 10,
               1977 under 359-620; prepared by Rhodia, Inc. in cooperation
               with Virginia Truck and Ornamentals Research Station, submitted
               by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:229758-AY)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate  For Use  in
                           Developing the Standard
005010532   Spynu, Y.I.; Vrochinskiy, K.K. ; Zor'yeva, T.-D. ; Man'ko, N.N.
               (1972) Kompleksnoye gigiyenicheskoye normirovaniye  novykh
               fosfororganischeskikh pestitsidov v ob'yektakh vneshney  sredy.
               pesticides in environmental objects.]  Gigiena i Sanitariya.

005014392   Stevenson, J.H. ; Walker, J.  (1975) Oil seed rape and honeybee
               poisoning.  Pages 497-501, _In Proceedings of the 8th British
               Insecticide and Fungicide Conference.  London, England:
               British Crop Protection Council.

000012490   Stier, E.F.  (1965) Flavor Evaluation Report on Tomatoes.   (Unpub-
               lished study received Nov 10, 1972 under 3F1323; prepared by
               Rutgers Univ., submitted by Ciba-Geigy Corp., Greensboro, N.C. ;
               CDL:093552-BY)

000006087   Stier, E.F.  (1971) Sensory Evaluation Report on Citrus.   (Unpub-
               lished study received on unknown date under 2F1193; prepared by
               Rutgers Univ., Dapt. of Food Science, submitted by Rhodia, Inc.,
               New Brunswick, N. J. ; CDL:093518-D)

005019250   Syoyama, M. ; Miyachi, Y. ; Sakakibara, J. (1976) Enkaparajium to
               p-nitoroso N,N-jiechiruanirin o riyoshita
               ganioyukirinkeisacchuzai no hishokuteiryo.  [Colorimetric
               determination of organothiophosphorus pesticides with  palladium
               chloride  and p-nitroso-N,N-diethylaniline. ]  Bunseki Kagaku.

000006593   Szabo, J. ; Sleesman, J.P. (1971) Zolone EC—Potatoes:  Final Report
               No. CH 71-103.  (Unpublished study received Dec 7,  1972 under
               3F1337; prepared in cooperation with Ohio State Univ., Dept. of
               Entomology, submitted by Rhodia, Inc., New Brunswick,  N. J. ;
               CDL:094849-E)

000006592   Szabo, J. ; Wells, A. (1971) Zolone EC — Potatoes: Final Report
               No. CH 71-61.  (Unpublished study received Dec 7, 1972 under
               3F1337; prepared in cooperation with Michigan State Univ., sub-
               mitted by Rhodia, Inc., New Brunswick, N. J. ; CDL:094849-D)

005009355   Szalontai, G. (1976) High-performance liquid chroma tog raphy of
               organophosphorus insecticides.  Journal of Chroma tog raphy
005013358   Tasei, J.N. ; Capou, J. ; Michaud, D.  (1977) Action de quelques
               insecticides sur une abeille solitaire: Megachile
               pesticides on a solitary bee: Megachile pacifica Panz.
               (Hymenoptera, Megachilidae) . ]  Apidologie  8 (2): 111-127.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
005009882   Tawata, S.; Eto, M.; Ishiguro, T.  (1978) Studies on
               oxazaphospholidines with pesticidal activities: I.  Synthesis
               and insecticidal activities of  2-chloromethyl-l,3,2-
               oxazaphospholidine 2-oxides.  Journal of  the Faculty of
               Agriculture, Kyushu University  22(3):169-177.

005016594   Tigane, E.Y. (1971) Vydelenie chistykh pestitsidnych preparatov  iz
               ikh tekhnicheskikh smesyei dlia primenieniya v kachestvie
               analiticheskikh etalonov.  [Separation of pure pesticide
               preparations from their technical mixtures "for use as
               analytical standards.]  Pages 373-375, In Trudy Vsesoyuznogo
               Soveshchaniya po Issledovaniyu  Ostatkov Pestitsidov i
               Profilaktike Zagryazneniya Imi  Produktov Pitaniya, Kormov  i
               Vneshnei Sredy, Metody Analiza, 2nd.   [Transactions of the 2nd
               Ail-Union Conference on the Residues of Pesticides and
               Prophylaxis of Contamination by Them of Foodstuffs, Feeds  and
               the Environment, Methods of Analysis.]; 1970, Tallin, USSR.
               Edited by O.M. Tamm.

005007126   Tolstova, Y.S. ; lonova, Z.A.  (1973)
               Chuvstivitelnost Trikhogrammy k pestitsidam.   [Sensitivity
               of Trichogramma to pesticides.]  Zaschita Rastenii (Moscow).

000006071   Totman, L.C.; Imming, R.J.; Wbodard, G. (1967) Phosalone: Analysis
               of Compound Residue in Tissues  of Beef Cattle and Sheep.   (Un-
               published study received Oct 16, 1967 under 9F0759; prepared by
               Woodard Research Corp., submitted by Rhodia, Inc., New Bruns-
               wick, N.J.; CDL:093071-E)

005010803   Travis, J.W. ; Hull, L.A.; Miller,  J.D. (1978) Toxicity of
               insecticides to the aphid predator Coccinella novemnotata  .
               Environmental Entomology 7(6):785-786.

005014543   Trondina, G.A.  (1978) Metod razdel'nogo opredeleniya ftalofosa i
               fozalona v rybe i vode.   [Method  for the separate determination
               of phthalophos and phosalone in fish and water.]  Veterinariya
               (Moscow).   [Veterinary Science.]  (6):96-98.

GS0027002   U.S.D.A.  (1969) Fish Toxicity Laboratory Report.  I.D. Number
              62841.   (Unpublished report concerning the toxicity of Zolone
              3EC on bluegills; prepared by the Animal Biology Laboratory, ARS-
              PR, ARC. Beltsville, MD)

GS0027001   U.S.D.A.  (1969) Fish Toxicity Laboratory Report.  I.D. Number
              62841.   (Unpublished report concerning the toxicity of Zolone
              3EC on rainbow trout; prepared by  the Animal Biology Laboratory,
              ARS-PR, ARC, Beltsville, MD)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
005015131   Ubaidullaev, R.; Kamil'dzhanov, A.K.  (1976) K toksikologii malykh
               kontsentratsii fozalona v atmosfernom vozdukhe.   [Toxicology of
               low concentrations of phosalone in the atmosphere.]  Gigiena i
               Sanitariya.   [Hygiene and Sanitation.] 41(7):10-14.

005012947   Ubaidullaev, R.U. (1973) Gigienicheskaia otsenka nekotorykh
               pestitsidov, primeniaemykh v usloviiakh zharkogo klimata.
               climate.]  Meditsinskii Zhurnal Uzbekistana.   [Medical Journal
               of Uzbekistan.] 8:40-44.

005014949   Valenta, V.T.; Zhegas, A.K. (1977) Fitotoksichnost' insektitsidov
               dlya sazhentsev sosny.   [Phytotoxicity of insecticides for pine
               tree seedlings.]  Khimiya v Sel'skom Khozyaistve.   [Chemistry
               in Agriculture.] 15(3):46-50.

005017186   Varchenko, V.N.  (1977) Vliyanie sistem opryskivaniya yabloni na
               chislennost1 entomofauny.   [Influence of systems for spraying
               apple trees on the entomofauna population.]  Khimiya v Sel'skom
               Khozyaistve.   [Chemistry in Agriculture.] 15(l):73-75.

005009798   Varma, R.S.; Nobles, W.L. (1968) Synthesis and antibacterial
               activity of certain 3-substituted benzoxazolinones.  Journal of
               Pharmaceutical Sciences 57(1):39-44.

005000787   Verma, S.R.; Bhatnagar, M.C.; Dalela, R.C.  (1978) Biocides in
               relation to water pollution. Part  2: bioassay studies of few
               biocides to a fresh water fish, Channa gachua  .  Acta
               Hydrochimica et Hydrobiologica 6(2):137-144.

005018285   Verma, S.R.; Tyagi, A.K.; Bhatnagar, M.C.; Dalela, R.C. (1979)
               Organophosphate poisoning to some  fresh water
               teleosts—acetylcholinesterase inhibition.  Bulletin of
               Environmental Contamination and Toxicology 21(4/5):502-506.

005014685   Veschambre, D.; Espanel, G.; Touzeau, J.; Grouiller, A. (1976)
               Tomates et residus pesticides.   [Tomatoes and pesticide
               residues.]  Pepinieristes Horticulteurs Maraichers  171:25-29.

005017544   Vioque, A.; Albi, T.  (1978) Determinacion de residues  de
               insecticidas  fosforados en aceitunas.   [Determination of
               phosphorus containing insecticide  residues in  olives.]  Grasas
               y Aceites  (Seville) 29(1):37-44.

005014540   Vrochinskii, K.K.  (1971) Nakoplenie pestitsidov v gidrobiontakh
               kak test dlya ikh otsenki eksperimental'noi vodnoi
               toksikologii.   [Accumulation of pesticides in  hydrobionts  as a
               measure  for evaluating experimental water  toxicology.]
               Eksperimental'naya  Vodnaya Toksikologiya.   [Experimental Water
               Tox icology.]  (2):149-163.

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
005014280   Vrochinskii, K.K. (1972) K prognozironvaniiu dinamiki ostatkov
               fozalona v vode vodoemov.   [Predicting phosalone residue
               dynamics in reservoir water.]  Rybnoe Khozyaistvo  (Moscow).

005019859   Vrochinskii, K.K. (1973) Vliyanie nekotorykh pestitsidov  na
               sanitarnii rezhim vodoema i organolepticheskie svoistva vody.
               the organoleptic characteristics of the water.]
               Eksperimental'naya Vodnaya Toksikologiya.   [Experimental Water
               Toxicology.]  (4):97-103.

005013278   Vylegzhanina, G.F.; Kalmykova, P.G. (1972) Kachestvennyi  i
               kolichestvennyi metody opredeleniia fozalona v iablokakh i
               iablonevykh list'iakh.   [Qualitative and quantitative  methods
               of determination of phosalone in apples and apple leaves.]
               Problemy Analiticheskoi Khimii.  [Problems of Analytical
               Chemistry.] 2:32-38.

000008167   Wagner, H.W.  (1972) Compatibility Study of Multiple Spray Material
               Combinations.  (Unpublished study received Mar 4, 1974 under
               352-362; prepared by Canada, Dept. of Agriculture, Research
               Station, submitted by E.I. du Pont de Nemours & Co., Wilmington,
               Del.; CDL:026710-E)

000006252   Wang, D. (1969)  Final Report: District Project No. PAW  69-3.   (Un-
               published  study including district project no. PAW 69-3A, re-
               ceived Mar 26, 1971 under 1F1155; submitted by Rhodia, Inc.,
               New Brunswick, N.J.; CDL:093474-W)

000006361   Wang, D. (1969)  Summary Report: District Project No. PAW  69-6.
               (Unpublished  study received May 6, 1970 under OF0983;  submitted
               by Rhodia, Inc., New Brunswick, N.J.; CDL:091692-D)

000006293   Wang, D. (1970)  Final Report: District Project No. PAW  70-10.   (Un-
               published  study received Mar 26, 1971 under 1F1155;  prepared in
               cooperation with Paul A. Mariani Co., submitted by Rhodia,  Inc.,
               New Brunswick, N.J.; CDL:093474-BQ)

000006288   Wang, D. (1970)  Final Report: District Project No. PAW  70-12.   (Un-
               published  study including district project no. 70-12A, received
               Mar 26, 1971  under 1F1155; prepared in cooperation with  Paul A.
               Mariani Co.,  submitted by Rhodia, Inc., New Brunswick, N.J.;
               CDL:093474-BK)

000006282   Wang, D. (1970)  Final Report: District Project No. PAW  70-14.   (Un-
               published  study received Mar 26, 1971 under 1F1155;  submitted
               by Rhodia, Inc., New Brunswick, N.J.; CDL:093474-BC)

300006289   Wang, D. (1970)  Final Report: District Project No. PAW  70-20 and
               20A.  (Unpublished study received Mar 26, 1971 under 1F1155;
               submitted by  Rhodia, Inc., New Brunswick, N.J.; CDL:093474-BM)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be  Inappropriate  For  Use  in
                           Developing the Standard
000006294
000006477
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000006115
000006145
000006431
000006253
000006064
005016364
000006658
Wang, D. (1970) Final Report: District  Project No.  PAW 70-22.   (Un-
   published study received Mar 26,  1971  under 1F1155;  submitted
   by Rhodia, Inc., New Brunswick, N.J.;  CDL:093474-BR)

Wang, D. (1970) Final Report: District  Project No.  PAW 70-29.
   (Unpublished study received Nov 18,  1971  under 359-626;  prepared
   by Rhodia, Inc., submitted by Rhone-Poulenc,  Inc.,  Monmouth
   Junction, N.J.; CDL:003175-N)

Wang, D. (1970) Summary Report: District  Project No. PAW 70-4c.
   (Unpublished study received Sep 2, 1970 under OF0983; submitted
   by Rhodia, Inc., New Brunswick, N.J.;  CDL:091693-C)

Wang, D. (1970) Summary Report: District  Project No. PAW 70-42.
   (Unpublished study received Sep 2, 1970 under OF0983; submitted
   by Rhodia, Inc., New Brunswick, N.J.;  CDL:091693-D)

Wang, D. (1972) Final Report: District  Project No.  FW  72-25.  (Un-
   published study received Mar 16,  1973  under 359-620;  prepared by
   Rhodia,  Inc.,  submitted by Rhone-Poulenc, Inc.,  Monmouth Junc-
   tion, N.J.; CDL:009830-C)

Wang, D. (1972) Final Report: District  Project No.  FW  72-25.  (Un-
   published study received Mar 16,  1973  under 359-620;  prepared by
   Rhodia,  Inc.,  submitted by Rhone-Poulenc, Inc.,  Monmouth Junc-
   tion, N.J.; CDL:008914-C)

Wang, D.; Kline,  N. (1969) Final Report:  District Project No. PAW
   69-4.   (Unpublished study received Mar 26,  1971 under 1F1155;
   prepared  in cooperation with Niagara Chemical Co.,  submitted by
   Rhodia,  Inc.,  New Brunswick, N.J.; CDL:093474-Y)

Wang, D.; Rough,  D. (1970) Final Report:  District Project No. FW
   71-92.   (Unpublished study received  Apr 12, 1972 under 1F1155;
   prepared  in cooperation with Univ. of  California, submitted by
   Rhodia,  Inc.,  New Brunswick, N.J.; CDL:096445-D)
Wang, R.T.  (1975) Phosalon  tze bi  se  ding  liang  fa.   [A
   colorimetric method  for  the determination of  phosalone.]
   Hsueh.   [Chemistry.]  (4):108-111.
                                                                          Hua
Washington State University,  Cooperative Extension Service (19??)
   Insecticide Toxicity  to  Honey Bees.   (Unpublished study in-
   cluding test no.  Port 68-67,  received Nov 17,  1975 under 359-
   620; submitted by Rhone-Poulenc,  Inc., Monmouth Junction,  N.J.;
   CDL:223344-L)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use  in
                           Developing the Standard
005010805   Weintraub, P.P.; Vylegjanina, G.F.; Nesterova, I.P.; Patrashku,
               F.I. (1975) Residual amounts of organophosphate insecticides  in
               plant products.  Pages 180-182, Jjn Pesticides: International
               Union of Pure and Applied Chemistry Third International
               Congress; Jul 3-9, 1974, Helsinki, Finland.  Edited by F.
               Coulston and F. Korte.  Stuttgart, West Germany:  George
               Thieme.  (Environmental quality and safety supplement, vol.
               Ill)

005009137   Weintraub, F.P.; Vylegzhanina, G.F.; Dron, L.P.; Kejser, L.S.;
               Nesterova, I.P.; Patrashku, F.I. (1978) Pathways of pesticide
               dissipation and decomposition.  Pages 140-156, Ir± Symposium on
               Environmental Transport and Transformation of Pesticides.
               Athens, Ga.:  U.S. Environmental Protection Agency,
               Environmental Research Laboratory.  (EPA report no.
               EPA-600/9-78-003; available from: NTIS, Springfield, VA; PB 280
               714)

005009309   Winterlin, W.; Mourer, C.; Bailey, J.B.  (1974) Degradation of four
               organophosphate insecticides in grape tissues.  Pesticides
               Monitoring Journal 8(1):59-65.

000006682   Woodard, G. (1966)  [Phosalone Chronic Dog Study: Clinical Chemistry
               Determinations Performed at 39-40 Weeks].  (Unpublished study
               including  letter dated Mar 5,  1966 from G. Woodard to Leslie  R.
               Reed, received Dec 12, 1966 under 7G0575; prepared by Woodard
               Research Corp., submitted by Chipman Chemical Co., Inc., Bur-
               lingame, Calif.; CDL:090728-A)

000006683   Woodard, M.W.; Cockrell, K.O.; Woodard, G. (1966) Phosalone:  Safety
               Evaluation by Repeated Oral Administration to Rats and Dogs for
               104 Weeks: Interim Report—53 Weeks.   (Unpublished study re-
               ceived Dec 12, 1966 under 7G0575; prepared by Woodard Research
               Corp., submitted by Chipman Chemical Co., Inc., Burlingame,
               Calif.; CDL:090728-B)

000006685   Woodard, M.W.; Cockrell, K.O.; Woodard, G. (1966) Phosalone:  Sub-
               acute Dermal Toxicity of Phosalone  (R.P. 11974) for the Rabbit.
               (Unpublished study received Dec 12, 1966 under 7G0575; prepared
               by Woodard Research Corp., submitted by Chipman Chemical Co.,
               Inc., Burlingame, Calif.; CDL:090728-D)

000006686   Woodard, M.W.; Cockrell, K.O.; Woodard, G. (1966) Phosalone:  Three-
               Generation Reproduction Study  in the Rat: Interim Report F-0
               Generation.  (Unpublished study received Dec  12, 1966 under
               7G0575; prepared by Woodard Research Corp., submitted by Chip-
               man Chemical Co., Inc., Burlingame, Calif.; CDL:090728-E)

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                          OFFICE OF PESTICIDE PROGRAMS
                       REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Examined and Judged to be Inappropriate For Use in
                           Developing the Standard
000006699   Woodard, M.W.; Greenstein, E.T.; Woodard, G.  (1966) Phosalone:
               Safety Evaluation by Repeated Oral Administration to Rats and
               Dogs for 104 Weeks: Interim Report—26 Weeks.   (Unpublished
               study received Dec 15, 1966 under 7G0575; prepared by Woodard
               Research Corp.; submitted by Chipman Chemical Co., Inc., Bur-
               lingame, Calif.; CDL:090729-O)

000006509   Woodard, M.W.; Howard, D.J.; Donoso, J.; Woodard, G. (1967) Phosa-
               lone: Safety Evaluation by Repeated Oral Administration to Rats
               for 103-104 Weeks.  (Unpublished study received on unknown date
               under 1F1155; prepared by Woodard Research Corp. for Chipman
               Chemical Co., Inc., submitted by Rhodia, Inc., New Brunswick,
               N.J.; CDL:098482-A)

005015525   Yaroshenko, V.I. (1974) Ekspress-metod diagnostiki otravleniya
               ptshel.   [Rapid method for the diagnosis of poisoning of bees.]
               Veterinariya  (Moscow).   [Veterinary Science.] (1):98-99.

005012297   Zhuravskaya, S.A.; Bobyreva, T.V.; Gargav, V.P.; Sobchak, M.N.;
               Sabirova, D.U. (1972) Izbiratel'naya toksichnost1
               fosfororganicheskikh preparatov dlya vrediteley khlopchatnika i
               ikh entomofagov.   [Selective toxicity of organophosphorus
               preparations for cotton pests and their predators.]   Uzbekskii
               Biologicheskii Zhurnal.   [Uzbek Biological Journal.]
               16(5):46-48.

005009799   Zlateva, M.; Softova, E.  (1976) Changes in the spleen of albino
               rats subjected to low-frequency vibration on the screen of
               chronic  intoxication with the pesticide "Zolon".  Folia
               Biologica 24(1):147-152.

005015533   Zlateva, M.; Softova, E.  (1977) Gistologicheskie i
               gistokhimicheskie issledovaniya miokarda belykh krys,
               podvergnutykh vozdeistviyu obshei vibratsii na  fone
               predvaritel'noi intoksikatsii fosfororganicheskim preparatom
               "zolon".   [Histological and histochemical  studies of  the
               myocardium  in albino rats subjected to the action of  general
               vibration against a background of preliminary poisoning with
               the organophosphoric preparation  "Zolon".]  Gigiena Truda  i
               Professional'nye Zabolevaniya.   [Labor Hygiene  and Occupational
               Diseases.]  21(l):43-47.

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