xvEPA
U ruted States
Environmental Protection
Agency
Office of
Pesticides and Toxic Substances
Washington DC 20460
August 1981
Pesticides
0,0-diethyl S-[(6-chloro-2-
oxobenzoxazolin-3-yl-)methyl]
phosphorodithioate
fPhosalone)
Pesticide Registration
Standard
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Phosalone
Pesticide Registration Standard
Carol E. Langley
Ingrid M. Sunzenauer
William Boodee
Daniel Byrd
Dennis Edwards
Roger Gardner
Linda Garczynski
Steve Hopkins
John Jordan
Richard Lee
Rosalie Metzger
Allen Scheid
E. David Thomas
Les Touart
Phil Williams
Ralph Wright
Project Manager (SPRD)
Project Manager (SPRD)
Chemist (RCB/HED)
Science Advisor (HED)
Assistant Product Manager (RD)
Toxicologist (TB/HED)
Writer/Editor (SPRD)
Plant Physiologist (EEB/HED)
Microbiologist (EFB/HED)
Entomologist (EEB/HED)
Chemist (RCB/HED)
Economist (EAB/BFSD)
Supervisory Entomologist (ASIB/BFSD)
Fisheries Biologist (EEB/HED)
Management Analyst (SPRD)
Project Manager (SPRD)
August 21, 1981
Office of Pesticides and Toxic Substances
Environmental Protection Agency
401 M Street, SW
Washington, D.C. 20460
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Errata Sheet for Phosalone Pesticide Registration
Standard, Office of Pesticides and Toxic Substances,
Environmental Protection Agency, Washington, D.C., 20460,
August, 1981.
The changes are as follows:
Insert Table 1, page 55a.
Insert Table 2, Page 60a.
Delete the following two citations from the Office of
Pesticide Programs Registration Standard Bibliography
entitled "Citations Examined and Judged to be Inappropriate
for Use in Developing the Standard":
000006386 Desmoras, J.; Laurent, M., Terlain, B; Aublet,
J.C.; Sasmayoux, J.C.; Savary, M. (1966) Study of the
Metabolism of Phosalone (11974 R.P.) in Plants: R.P.—D.S.
Ph. No. 11686. (Unpublished study received February 2, 1967
under 7G0575; prepared by Societe des Usines Chimiques
Rhone-Poulenc, submitted by Chipman Chemical Company, Inc.,
Burlingame, California; CDL; 090727-E)
000006674 Societe des Usines Chimiques Phone-Poulenc (1968)
R.P.: Oxygen Analogue of Phosalone: Acute Oral Toxicity and
Anticholinesterasic Activity in Vitro: R.P.—D.S. Ph. No.
12644. (Unpublished study received June 14, 1968 under
8F0668; Submitted by Chipman Chemical Company, Inc.,
Burlingame, California, CDL: 091170-B)
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- TABLE OF CONTENTS -
page
Chapter I How to Register under a Registration Standard 2
Chapter II Regulatory Position and Rationale 10
Chapter III Summary of Data Requirements and Data Gaps 19
Chapter IV Product Chemistry 41
Chapter V Environmental Fate 46
Chapter VI Toxicology 55
Chapter VII Residue Chemistry 63
Chapter VIII Ecological Effects 72
Bibliography 75
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CHAPTER I: HOW TO REGISTER UNDER A REGISTRATION STANDARD
A. Organization of the Standard
B. Purpose of the Standard
C. Requirement to Reregister Under the Standard
D. "Product Specific" Data and "Generic" Data
E. Data Compensation Requirements under FIFRA 3(c)(l)(D)
F. Obtaining Data to Fill "Data Gaps"; FIFRA 3(c)(2)(B)
G. Amendments to the Standard
A. Organization of the Standard
This first chapter explains the purpose of a Registration Standard and
summarizes the legal principles involved in registering or reregistering under
a Standard. The second chapter involves the regulatory position and the
rationale supporting this position. The third chapter sets forth the data
requirements that must be met to obtain or retain registration for products
covered by this particular Registration Standard. In the remaining chapters,
the Agency reviews the available data by scientific discipline, discusses the
Agency's concerns with the identified potential hazards.
B. Purpose of the Standard
Section 3 of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
provides that "no person in any State may distribute, sell, offer for sale,
hold for sale, ship, deliver for shipment, or receive (and having so received)
deliver or offer to deliver, to any person any pesticide which is not
registered with the Administrator [of EPA]." To approve the registration of a
pesticide, the Administrator must find, pursuant to Section 3(c)(5) that:
"1. its composition is such as to warrant the proposed claims for it;
2. its labeling and other material required to be submitted comply
with the requirements of this Act;
3. it will perform its intended function without unreasonable adverse
effects on the environment; and
4. when used in accordance with widespread and commonly recognized
practice it will not generally cause unreasonable adverse effects
on the environment."
In making these findings, the Agency reviews a wide range of data which
registrants are required to submit, and assesses the risks and benefits
associated with the use of the proposed pesticide. However, the established
approach to making these findings has been found to be defective on two counts.
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First, EPA and its predecessor agency, the United States Department of
Agriculture (USDA), routinely reviewed registration applications on a "product
by product" basis, evaluating each product-specific application somewhat
independently. In the review of products containing similar components, there
was little opportunity for a retrospective review of the full range of
pertinent data available in Agency files and in the public literature. Thus
the "product by product" approach was often inefficient and sometimes resulted
in inconsistent or incomplete regulatory judgments.
Second, over the years, as a result of inevitable and continuing advances in
scientific knowledge, methodology, and policy, the data base for many
pesticides came to be considered inadequate by current scientific and
regulatory standards. Given the long history of pesticide regulation in
several agencies, it is even likely that materials may have been lost from
the data files. When EPA issued new requirements for registration in 1975 (40
CFR 162) and proposed new guidelines for hazard testing in 1978 (43 FR 29686,
July 10/1978 and 43 FR 37336, August 22, 1978), many products that had already
been registered for years were being sold and used without the same assurances
of human and environmental safety as was being required for new products.
Because of this inconsistency, Congress directed EPA to reregister all
previously registered products, so as to bring their registrations and their
data bases into compliance with current requirements [See FIFRA Section 3(g)].
Facing the enormous job of re-reviewing and calling-in new data for the
approximately 35,000 current registrations, and realizing the inefficiencies of
the "product by product" approach, the Agency decided that a new, more
effective method of review was needed.
A new review procedure has been developed. Under it, EPA publishes documents
called Registration Standards, each of which discusses a particular pesticide
active ingredient. Each Registration Standard summarizes all the data
available to the Agency on a particular active ingredient and its current uses,
and sets forth the Agency's comprehensive position on the conditions and
requirements for registration of all -existing and future products which contain
that active ingredient. These conditions and requirements, all of which must
be met to obtain or retain full registration or reregistration under Section
3(c)(5) of FIFRA, include the submission of needed scientific data which the
Agency does not now have, compliance with standards of toxicity, composition,
labeling, and packaging, and satisfaction of the data compensation provisions
of FIFRA Section 3(c)(l)(D).
The Standard will also serve as a tool for product classification. As part of
the registration of a pesticide product, EPA may classify each product for
"general use" or "restricted use" [FIFRA Section 3(d)]. A pesticide is
classified for "restricted use" when some special regulatory restriction is
needed to ensure against unreasonable adverse effects to man or the
environment. Many such risks of unreasonable adverse effects can be lessened
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if expressly-designed label precautions are strictly followed. Thus the special
regulatory restriction for a "restricted use" pesticide is usually a
requirement that it be applied only by, or under the supervision of, an
applicator who has been certified by the State or Federal government as being
competent to use the pesticide safely, responsibly, and in accordance with
label directions. A restricted-use pesticide can have other regulatory
restrictions [40 CFR 162.11(c)(5)] instead of, or in addition to, the certified
applicator requirement. These other regulatory restrictions may include such
actions as seasonal or regional limitations on use, or a requirement for the
monitoring of residue levels after use. A pesticide classified for "general
use," or not classified at all, is available for use by any individual who is
in compliance with State or local regulations. The Registration Standard
review compares information about potential adverse effects of specific uses of
the pesticide with risk criteria listed in 40 CFR 162.11(c), and thereby
determines whether a product needs to be classified for "restricted use." If
the Standard does classify a pesticide for "restricted use," this determination
is stated in the second chapter.
C. Requirement to Reregister Under the Standard
FIFRA Section 3(g), as amended in 1978, directs EPA to reregister all currently
registered products as expeditiously as possible. Congress also agreed that
reregistration should be accomplished by the use of Registration Standards.
Each registrant of a currently registered product to which this Standard
applies, and who wishes to continue to sell or distribute his product in
commerce, must apply for reregistration. His application must contain proposed
labeling that complies with this Standard.
EPA will issue a notice of intent to cancel the registration of any currently
registered product to which this Standard applies if the registrant fails to
comply with the procedures for reregistration set forth in the Guidance Package
which accompanies this Standard.
D. "Product Specific" Data and "Generic" Data
In the course of developing this Standard, EPA has determined the types of data
needed for evaluation of the properties and effects of products to which the
Standard applies, in the disciplinary areas of Product Chemistry, Environmental
Fate, Toxicology, Residue Chemistry, and Ecological Effects. These
determinations are based primarily on the data Guidelines proposed in 43 FR
29696, July 10, 1978; 43 FR 37336, August 22, 1978; and 45 FR 72948,
November 3, 1980, as applied to the use patterns of the products to which this
Standard applies. Where it appeared that data from a normally applicable
Guidelines requirement was actually unnecessary to evaluate these products, the
Standard indicates that the requirement has been waived. On the other hand, in
some cases studies not required by the Guidelines may be needed because of the
particular composition or use pattern of products the Standard covers; if so,
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the Standard explains the Agency's reasoning. Data guidelines have not yet
been proposed for the Residue Chemistry discipline, but the requirements for
such data have been in effect for some time and are, the Agency believes,
relatively familiar to registrants. Data which we have found are needed to
evaluate the registrability of some products covered by the Standard may not be
needed for the evaluation of other products, depending upon the composition,
formulation type, and intended uses of the product in question. The Standard
states which data requirements apply to which product categories. (See the
third chapter.) The various kinds of data normally required for registration
of a pesticide product can be divided into two basic groups:
1. Data that are product specific , i.e. data that relate only
to the properties or effects of a product with a particular
composition (or a group of products with closely similar
composition); and
2. Generic data that pertain to the properties or effects of a
particular ingredient, and thus are relevant to an evaluation of
the risks and benefits of all products containing that ingredient
(or all such products having a certain use pattern), regardless
of any such product's unique composition.
The Agency requires certain "product specific" data for each product to
characterize the product's particular composition and physical/chemical
properties (Product Chemistry), and to characterize the product's acute
toxicity (which is a function of its total composition). The applicant for
registration or reregistration of any product, whether it is a manufacturing-
use or end-use product, and without regard to its intended use pattern, must
submit or cite enough of this kind of data to allow EPA to evaluate the
product. For such purposes, "product specific" data on any product other than
the applicant's is irrelevant, unless the other product is closely similar in
composition to the applicant's. (Where it has been found practicable to group
similar products for purposes of evaluating, with a single set of tests, all
products in the group, the Standard so indicates.) "Product specific" data on
the efficacy of particular end-use products are also required where the exact
formulation may affect efficacy and where failure of efficacy could cause
public health problems.
All other data needed to evaluate pesticide products concern the properties or
effects of a particular ingredient of products (normally a pesticidally active
ingredient, but in some cases a pesticidally inactive, or "inert",
ingredient). Some data in this "generic" category are required to evaluate the
properties and effects of all products containing that ingredient [e.g., the
acute LD-50 of the active ingredient in its technical or purer grade; see
proposed guidelines, 43 FR 37355].
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Other "generic" data are required to evaluate all products which both contain a
particular ingredient and are intended for certain uses (see, e.g., proposed
guidelines,43 FR 37363, which requires subchronic oral testing of the
active ingredient with respect to certain use patterns only). Where a
particular data requirement is use-pattern dependent, it will apply to each end-
use product which is to be labeled for that use pattern (except where such end-
use product is formulated from a registered manufacturing-use product
permitting such formulations) and to each manufacturing-use product with
labeling that allows it to be used to make end-use products with that use
pattern. Thus, for example, a subchronic oral dosing study is needed to
evaluate the safety of any manufacturing-use product that legally could be used
to make an end-use, food-crop pesticide. But if an end-use product's label
specified it was for use only in ways that involved no food/feed exposure and
no repeated human exposure, the subchronic oral dosing study would not be
required to evaluate the product's safety; and if a manufacturing-use product's
label states that the product is for use only in making end-use products not
involving food/feed use or repeated human exposure, that subchronic oral study
would not be relevant to the evaluation of the manufacturing-use product either.
If a registrant of a currently registered manufacturing-use or end-use product
wishes to avoid the costs of data compensation [under FIFRA Section 3(c)(l)(D)]
or data generation [under Section 3(cj(2)(B)] for "generic" data that is
required only with respect to some use patterns, he may elect to delete those
use patterns from his labeling at the time he reregisters his product. An
applicant for registration of a new product under this Standard may similarly
request approval for only certain use patterns.
E. Data Compensation Requirements under FIFRA 3(c)(l)(D)
Under FIFRA Section 3(c)(l)(D), an applicant for registration, reregistration,
or amended registration must offer to pay compensation for certain existing
data the Agency has used in developing the Registration Standard. The data for
which compensation must be offered are all data which are described by all of
the following criteria:
1. The data were first submitted to EPA (or to its predecessor
agencies, USDA or FDA), on or after January 1, 1970;
2. The data were submitted to EPA (or USDA or FDA) by some other
applicant or registrant in support of an application for an
experimental use permit, an amendment adding a new use to a
registration, or for registration, or to support or maintain
an existing registration;
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3. They are the kind of data which are relevant to the Agency's
decision to register or reregister the applicant's product
under the Registration Standard, taking into account the
applicant's product's compositioa and intended use pattern(s);
4. The Agency has found the data to be valid and usable in reaching
regulatory conclusions; and
5. They are not data for which the applicant has been exempted by
FIFRA Section 3(c)(2)(D) from the duty to offer to pay
compensation. (This exemption applies to the "generic" data
concerning the safety of an active ingredient of the applicant's
product, not to "product specific" data. The exemption is
available only to applicants whose product is labeled for end-
uses for which the active ingredient in question is present in
the applicant's product because of his use of another registered
product containing that active ingredient which he purchases from
another producer.
An applicant for reregistration of an already registered product under this
Standard, or for registration of a new product under this Standard, accordingly
must determine which of the data used by EPA in developing the Standard must be
the subject of an offer to pay compensation, and must submit with his
application the appropriate statements evidencing his compliance with FIFRA
Section 3(c)(l)(D).
An applicant would never be required to offer to pay for "product specific"
data submitted by another firm. In many, if not in most cases, data which are
specific to another firm's product will not suffice to allow EPA to evaluate
the applicant's product, that is, will not be useful to the Agency in
determining whether the applicant's product is registrable. There may be
cases, however, where because of close similarities between the composition of
two or more products, another firm's data may suffice to allow EPA to evaluate
some or all of the "product specific" aspects of the applicant's product. In
such a case, the applicant may choose to cite that data instead of submitting
data from tests on his own product, and if he chooses that option, he would
have to comply with the offer-to-pay requirements of Section 3(C)(1)(D) for
that data.
Each applicant for registration or reregistration of a manufacturing-use
product, and each applicant for registration or reregistration of an end-use
product, who is not exempted by FIFRA Section 3(c)(2)(D), must comply with the
Section 3(c)(l)(D) requirements with respect to each item of "generic" data
that relates to his product's intended uses.
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A detailed description of the procedures an applicant must follow in applying
for reregistration (or new registration) under this Standard is found in the
Guidance Package for this Standard.
F. Obtaining Data to Fill "Data Gaps"; FIFRA 3(c)(2)(B)
Some of the kinds of data EPA needs for its evaluation of the properties and
effects of products to which this Standard applies have never been submitted to
the Agency (or, if submitted, have been found to have deficiencies rendering
them inadequate for making registrability decisions) and have not been located
in the published literature search that EPA conducted as part of preparing this
Standard. Such instances of missing but required data are referred to in the
Standard as "data gaps".
FIFRA Section 3(c)(2)(B), added to FIFRA by the Congress in 1978, authorizes
EPA to require registrants to whom a data requirement applies to generate (or
otherwise produce) data to fill such "gaps" and submit those data to EPA. EPA
must allow a reasonably sufficient period for this to be accomplished. If a
registrant fails to take appropriate and timely steps to fill the data gaps
identified by a section 3(c)(2)(B) order, his product's registration may be
suspended until the data are submitted. A mechanism is provided whereby two or
more registrants may agree to share in the costs of producing data for which
they are both responsible.
The Standard lists, in the third chapter, the "generic" data gaps and notes the
classes of products to which these data gaps pertain. The Standard also points
out that to be registrable under the Standard, a product must be supported by
certain required "product specific" data. In some cases, the Agency may
possess sufficient "product specific" data on one currently registered product,
but may lack such data on another. Only those Standards which apply to a very
small number of currently registered products will attempt to state
definitively the "product specific" data gaps on a "product by product"
basis. (Although the Standard will in some cases note which data that EPA does
possess would suffice to satisfy certain "product specific" data requirements
for a category of products with closely similar composition characteristics.)
As part of the process of reregistering currently registered products, EPA will
issue Section 3(c)(2)(B) directives requiring the registrants to take
appropriate steps to fill all identified data gaps — whether the data in
question are "product specific" or "generic" — in accordance with a schedule.
Persons who wish to obtain registrations for new products under this Standard
will be required to submit (or cite) sufficient "product specific" data before
their applications are approved. Upon registration, they will be required
under Section 3(c)(2)(B) to take appropriate steps to submit data needed to
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fill "generic" data gaps. (We expect they will respond to this requirement by
entering into cost-sharing agreements with other registrants who previously
have been told they must furnish the data.) The'Guidance Package for this
Standard details the steps that must be taken by registrants to comply with
Section 3(c)(2)(B).
G. Amendments to the Standard
Applications for registration which propose uses or formulations that are not
presently covered by the Standard, or which present product compositions,
product chemistry data, hazard data, toxicity levels, or labeling that do not
meet the requirements of the Standard, will automatically be considered by the
Agency to be requests for amendments to the Standard. In response to such
applications, the Agency may request additional data to support the proposed
amendment to the Standard, or may deny the application for registration on the
grounds that the proposed product would cause unreasonable adverse effects to
the environment. In the former case, when additional data have been
satisfactorily supplied, and providing that the data do not indicate the
potential for unreasonable adverse effects, the Agency will then amend the
Standard to cover the new registration.
Each Registration Standard is based upon all data and information available to
the Agency's reviewers on a particular date prior to the publication date.
This "cut-off" date is stated at the beginning of the second chapter. Any
subsequent data submissions and any approved amendments will be incorporated
into the Registration Standard by means of addenda, which are available for
inspection at EPA in Washington, D.C., or copies of which may be requested from
the Agency. When all the present "data gaps" have been filled and the
submitted data have been reviewed, the Agency will revise the Registration
Standard. Thereafter, when the Agency determines that the internally
maintained addenda have significantly altered the conditions for registration
under the Standard, the document will be updated and re-issued.
While the Registration Standard discusses only the uses and hazards of products
containing the designated active ingredient(s), the Agency is also concerned
with the potential hazards of some inert ingredients and impurities.
Independent of the development of any one Standard, the Agency has initiated
the evaluation of some inert pesticide ingredients. Where the Agency has
identified inert ingredients of concern in a specific product to which the
Standard applies, these ingredients will be pointed out in the Guidance Package.
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CHAPTER II: REGULATORY POSITION AND RATIONALE
A. Introduction
B. Description of Chemical
C. Regulatory Position
D. Regulatory Rationale
E. Criteria for Registration under the Standard
F. Required Labeling
G. Tolerance Reassessment
A. Introduction
This chapter presents the Agency's regulatory position and rationale based on
an evaluation of all registered products containing phosalone as the sole
active ingredient. After briefly describing the chemical, this chapter presents
the regulatory position and rationale, the criteria by which applicants for
registration of phosalone products will be approved, labeling considerations,
and tolerance reassessment. A summary of data requirements is contained in
Chapter III. A discussion of the data upon which this regulatory position is
based is presented within the disciplinary chapters, IV through VIII. Also
considered in this standard are Special Local Need (SLN) registrations, which
are issued by a State in accordance with FIFRA section 24 (c). Valid State
registrations will be subject to rereg istration under the EPA Registration
Standard System, in the same manner as a registration issued under section 3 of
FIFRA. Currently such a registration has been granted to California for the
application by aircraft to almonds, grapes, stone fruits and walnuts.
B. Description of Chemical
Phosalone (0,0-diethyl S-[(6-chloro-2-oxobenzoxazolin-3-yl-)methyl]
phosphorodithioate) is registered as an insecticide and miticide for use on a
variety of fruit, nut, vegetable and ornamental crops. The Chemical Abstracts
Service (CAS) Registry number is 2310-17-10. The OPP Internal Control Number
(EPA Shaughnessy number) is 097701.
The structural formula is:
P-S-CH -N — C
C-Hr-0 I II
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C. Regulatory Position
Phosalone as described in this Standard may be registered for
sale, distribution, reformulation and use in the United States and its
territories. The Agency has considered the scientific data obtained from
the open literature as of July I, 1981, and those data submitted by the
registrants up through the time of publication of this Standard. Based upon
the review of these data, the Agency finds that none of the risk
criteria found in section 162.11 (a) of Title 40 of the U.S. Code of Federal
Regulations were met or exceeded for phosalone. The Agency has determined that
phosalone has not been demonstrated to cause unreasonable adverse effects, to
either man or the environment, when used in accordance with prescribed label
directions and precautions. Phosalone products currently registered may be
reregistered subject to the conditions imposed by this chapter, and to the data
requirements identified in Chapter III. New products may be registered under
this Standard and are subject to the same requirements.
D. Regulatory Rationale
The Agency has reviewed data on phosalone concerning toxicology, ecological
effects, residue and product chemistry, and environmental fate. The
toxicological effects data base is reasonably complete, except for acute
inhalation toxicity, primary dermal irritation, primary eye irritation, dermal
sensitization, subchronic 21-day dermal, and acute delayed neurotoxicity data
for the manufacturing-use product. Primary dermal irritation and dermal
sensitization data are still needed for the end-use products. Data are also
still needed for primary eye irritation for the wettable powder formulation.
The residue chemistry data base is complete. There are some gaps in the data
base for product chemistry, and environmental fate. Much of the data base is
missing for ecological effects. Because there are no registered public health
related uses, the Agency has waived the need for efficacy data to support the
uses of phosalone. Despite the existing data gaps, the Agency has concluded
that the registration for this chemical should continue for the following
reasons:
1. No valid, adverse effects data of regulatory concern have been revealed
in the review of the studies made available to the Agency. The Agency*
therefore, has concluded that the known risks, as mitigated by product
labeling, do not warrant any immediate adverse regulatory action.
2. Although phosalone has been implicated in a few poisoning incidents, the
data do not conclusively indicate any hazards associated with
the normal use of phosalone.
a. The Pesticide Incidence Monitoring System (PIMS report) lists 12
incidents involving phosalone. However, eleven of these incidents
could not conclusively implicate phosalone, because of excessive
alcohol consumption, improper use of safety equipment, failure to
10
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follow recommended safety regulations, and other reasons. The one
valid incident was isolated and did not indicate a consistent
pattern of hazard associated with the recommended use of phosalone.
b. In 1973 there was a significant illness episode in Fowler, California
involving 32 pickers, who harvested grapes more than one month after
the application of phosalone, ethion, Imidan and dialifor. Although
phosalone might have caused the cholinesterase inhibition symptoms,
it is also important to consider the possibility of interactive
potentiation, since these workers were exposed to more than one
pesticide. Therefore, phosalone per se cannot be implicated as the
sole cause of the symptoms (Maddy, K.T., 1976, MRID 005001833).
c. Another illness episode occurred in a vineyard near Madera,
California. Cholinesterase depression and cholinergic symptoms were
reported among 118 field workers harvesting grapes, which had been
treated with dialifor and phosalone between 15 and 40 days earlier.
The conclusion of this study indicates that the 21-fold difference in
the toxicity of the two chemicals indicates that the effects were
probably produced by dialifor and not by phosalone (Knaak et al.,
1978, MRID 005003635).
3. In accordance with FIFRA, the Agency's policy is not to cancel or to
withhold registration merely for the lack of data. (See Sections
3(c)(2)(B) and 3(c)(7) of FIFRA.) Rather, publication of the Standard
provides a mechanism for identifying data needs, and registration under
the Standard allows for upgrading of labels during the period in which
the required data are being generated. When these data are received,
they will be reviewed by the Agency. The Agency will then determine
whether these data will affect the registration of this chemical.
E. Criteria for Registration Under The Standard
To be subject to this Standard, products must meet the following conditions:
- contain phosalone as the sole active ingredient,
- bear required labeling, and
- conform to the product composition standard, acute toxicity limits, and
use pattern requirements as discussed in the Manufacturing-Use and End-Use
Product sections, which follow.
The applicant for registration or reregistration of products subject to this
Standard must comply with all terms and conditions described in this Standard,
including a commitment to fill data gaps on a time schedule specified by the
Agency and, when applicable, offering to pay compensation to the extent
required by 3(c)(l)(D) of the Federal Insecticide, Fungicide and Rodenticide
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Act (FIFRA), as amended, 7 U.S.C. 136a(c)(1)(D). As discussed in Chapter I,
applicants for registration under this Standard should contact the Agency for
specific instructions, including updated information on data requirements and
companies whose data must be cited and to whom compensation must be offered.
1. Manufacturing-Use Products
a. Product Composition Standard
To be covered under this Standard, manufacturing-use products must contain
phosalone as their sole active ingredient., Such formulations must contain
contain 94 percent active ingredient. Each formulation proposed for
registration must be fully described within an appropriate certification of
limits.
b. Acute Toxicity Limits
The Agency will consider registration of manufacturing-use products containing
phosalone regardless of the toxicity category, provided that the labeling of
such products bears appropriate precautionary statements.
c. Use Patterns
To be covered under this Standard, manufacturing-use only products of phosalone
must be labeled to allow for formulation only into end-use insecticides/
miticides, which are intended for uses accepted by the United States
Environmental Protection Agency.
2. End-Use Products
a. Product Composition Standard
Emulsifiable concentrate (EC) phosalone products containing 34.4 percent
(3 pounds per gallon) active ingredient or less and wettable powder (WP)
formulations of 25 percent active ingredient or less will be considered under
this standard.The appropriate certification of limits must be provided and the
application rates on a per acre basis must remain the same or be less.
b. Acute Toxicity Limit
The Agency will consider for registration end-use products of any toxicity
category. This acceptance, however, is predicated upon label incorporations of
appropriate hazard warnings, as well as precautionary and use restrictions
as required.
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c. Use Pattern
To be considered under this standard, end-use products must bear directions for
use as an insecticide/miticide, which are intended for outdoor commercial,
ground and aerial applications (food or nonfood uses). The use pattern of this
insecticide/miticide may be expanded to include outdoor domestic, ground
application (food or nonfood uses), if the product is in child-resistant
packaging as described in 40 CFR 162.16. Sites of application include apples,
apricots, artichokes, cherries, grapefruit, grapes, lemons, nectarines, nuts,
oranges, peaches, pears, potatoes, prunes, arborvitae, and roses.
F. Required Labeling
All manufacturing-use and end-use phosalone products must bear
appropriate labeling as specified in 40 CFR 162.10. The guidance package
which accompanies this standard contains specific information regarding label
requirements.
The following antidote information should also appear on all labels:
"Causes cholinesterase inhibition. Atropine is antidotal. 2-PAM is also
antidotal and may be administered in conjunction with atropine. Warning
symptoms include weakness, headache, tightness in the chest, blurred
vision, nonreactive pinpoint pupils, salivation, sweating, nausea,
vomiting, diarrhea, and abdominal cramps."
The registrant may submit an alternative antidote statement for Agency
consideration.
Additional label restriction statements, grouped by manufacturing-use and end-
use products, are as follows:
1. Manufacturing-Use Products
All manufacturing-use product labels must bear the following
statement:
"For Formulation into End-Use Insecticide/Miticide Products Intended
Only for Uses Accepted by the United States Environmental Protection
Agency."
13
-------
2. End-use Products
a. Human Hazard Precautionary Statements
1). All EC products must require the use of goggles in their warning
statements, because of the high acute eye irritation hazard. (Please refer to
Chapter VI on toxicology for a discussion.)
2). The Agency is currently developing Guidelines for reentry
intervals. In addition the Agency is currently reviewing the 24 hour reentry
interval, which was established in 40 CFR 170. (Please refer to Chapter V for
a detailed discussion.) Until the Guidelines and reentry interval review are
complete, the Agency will require a 24 hour reentry interval. Therefore, the
following statement must appear on the label:
"Reentry into treated fields is prohibited within 24 hours of
application."
b. Environmental Hazard Statements
Sufficient information is available to consider phosalone as being of low to
moderate toxicity to pollinators. This toxicity may be mitigated, if phosalone
is applied when the pollinators are not foraging. Therefore, the following
statement must appear on all labels:
"This product is toxic to bees exposed to direct treatment or residues
on blooming crops or weeds. Do not apply this product if bees are
visiting the treatment area."
c. Additional Labeling
These statements are required in addition to those standard precautionary
statements outlined by the guidance package.
1). Because the Agency lacks supporting acute human health effects
and environmental fate data, the following statement must appear on the label.
"This product is not for use in greenhouses."
2). Because phosalone meets the criteria established in the child-
resistant packing regulations (40 CFR 162.16), all products must be packaged
in such containers, unless the following restriction appears on the label:
"For agricultural or commercial use only."
H
-------
3). There are data concerning the accumulation of phosalone in
rotational crops, which indicate that phosalone and/or its metabolites are
taken up by radishes, beans, potatoes, and wheat under greenhouse conditions
(Ambrosi et al., 1977, MRID 000006664). Therefore, the Agency has determined
that a crop rotation restriction must appear on the label as follows:
"Do not use in crop rotation programs."
As an alternative to this label restriction, the registrant may choose to
pursue any one of the following three options:
a). Supply environmental fate data supporting a rotation interval
which does not result in a pesticide residue in the rotated
crops; or
b). Obtain a tolerance for the nontarget crop (46 FR 3018); or
c). Obtain an exemption from a tolerance for the nontarget crop.
In the interim, however, the label amendment described previously will be
required.
4). Because of the potential toxicity to animals shown by the animal
metabolism data and residue information in Chapter VII, the following must
appear on the label:
"Do not allow livestock to graze cover crops in orchards or nut groves
treated with phosalone. Do not feed cover crops treated with phosalone
to livestock."
G. Tolerance Reassessment
A listing of the tolerances for residues of phosalone in or on raw agricultural
commodities as stated in 40 CFR 180.263 and 21 CFR 193.340 is found in Chapter
VII.Data summarized in this standard support these tolerances.
A report by the Food and Drug Administration shows that under the FDA
Regulatory Enforcement Program during the Fiscal Years 1977 thru 1980
approximately 1,480 agricultural crops were sampled and analyzed. About 86 of
these samples showed the presence of small amounts of phosalone. None of the
reported residues exceeded the residue tolerance levels established for
15
-------
phosalone for these crops. A summary of EPA estimated daily intakes of
phosalone based on these data in terms of mgAg of body weight/day is reported
as follows:
FY 1973 FY 1974 FY 1975 FY 1976
phosalone 0.000002 0.00002 0.00004 0.000001
A list of the CODEX Tolerances is also found in Chapter VII. The CODEX
tolerance for pecans and chestnuts (nuts) is 0.1 ppm, while the U.S. tolerance
for all nuts (including pecans and chestnuts) is 0.05 ppm. Both tolerances are
based on the sensitivity of the method used. In accordance with Agency policy
of cooperation with FAO/WHO and the Codex Alimentarius Commission, and to
eliminate possible barriers to international trade, the Administrator will
initiate the change of 0.05 ppm to 0.1 ppm for pecans and chestnuts (nuts)
under the authority of the Federal Food, Drug and Cosmetic Act, Section 408 (e)
and 40 CFR 180.32. Since there would be an insignificant change in the present
Theoretical Maximum Residue Concentration (TMRC), this would make the U.S.
tolerance consistent with the CODEX tolerance. The TMRC is based on
established tolerances for phosalone residues in or on raw agricultural crops.
The U.S. registered uses for all other crops indicate it would not be advisable
to change their tolerances.
In calculating the TMRC the Agency assumes that the chemical is applied to all
commodities on which its use is authorized, that each commodity contains the
maximum level allowed in the tolerance, and that average 60 kilogram adult
eating patterns result in 100 percent of the phosalone-treated food in the
adult diet of 1.5 kilogram per day.
Based on the published tolerances for phosalone in all crops for which it is
registered, the theoretical maximum residue concentration (TKRC) is 1.0107
milligram per day for a 1.5 kilogram diet for 13.5 percent of the maximum
permissible intake (MPI). The TMPC for all eleven registered nut crops is
0.00022 milligram per day. If the tolerance is increased from 0.05 to 0.10
ppm, the nut 1MRC will be doubled to 0.00044 milligram per day, and the new
total 1MRC will be 1.0109 milligram per day. Increasing the 1MRC from 1.0107
to 1.0109 will result in virtually no change in the percentage ADI. The
increase is approximately 0.02 percent of the ADI. The revised TMRC (1.0109
milligram per day) is 0.0168 milligram of phosalone per kilogram body weight
per day for a 60 kilogram person. Therefore, there are no toxicological
reasons for objecting to the revision of 0.05 ppm tolerance in nuts to 0.1 ppm.
To calculate the Acceptable Daily Intake (ADI) for the purpose of assessing the
toxicological significance of revising tolerances, a no-observed-effect-level
(NOEL) of 25 ppn is taken from the two-year rat feeding study (Woodard et al.,
1967, MRID 000006202). This is equivalent to a 1.25 milligram per kilogram
per day NOEL. Using a safety factor of ten (for extrapolation from a chronic
study in rats to man with respect to cholinesterase inhibition), the acceptable
16
-------
daily intake (ADI) is 0.125 milligram per kilogram per day (determined by
dividing the NOEL in milligram per kilogram by ten). The MPI is determined by
multiplying the ADI by 60 kilogram (assumed average body weight for humans),
and is 7.5 milligram per person per day.
The tolerance for nuts was the only one for which a change was accepted. All
established tolerances are considered adequate to protect public health.
17
-------
TABLE 1
Summary of acute oral LDrn values (ing/kg body weight) for
manufacturing-use phosalbne
Animal
Rats
Sex
Males
Females
Male and
Female
^50
90 (68-119)-
120 (105-135)
Reference
Fournel et al . ,
1968, MRID 000006716
Pasquet et al .
1976, MRID 005007746
Females
135
Dubost et al . , 1963 ,
MRID 000006643
Mice
Unspecified 130
190
Rivett and Davies, 1966,
MRID 000006697
Unspecified 180
435-7
Dubost et al . , 1963 ,
MRID OOOOOC643
Guinea Pig Unspecified 150
Dubost ct al . , 1963 ,
MRID 000006643
I/ 95% confidence intervals are given in parentheses.
_2/ Phosalono was adninistered in an oil solution. All other
LDc- 's were determined with phosalone in aqueous
suspens ion.
-55a-
-------
TABLE 2
Summary of acute oral L
of Phosalone
values (mg/kg) for formulations
O
0)
I
Animal
Rats
Mice
Sex
Male and
Female
Males
Halves
Females
Male
Females
Unspecified
Formulation
WP
WP
EC
EC
EC
EC
EC
^50
480
600
274
(195-385)-7
261
(169-403)-7
488
>480
Reference
US EPA, 1973,
MRID GS0027005
US EPA, 1976,
MRID GS0027003
Scott and Deliles,
1965, MRID 00006688
190-'
US EPA, 1973,
MIUD GS0027006
US CPA, 1972,
MRID GS0027004
Rivett and Duvies
1966, KRID 00006697
I/ 95% confidence limits
2:/ Test material was 13 and 14 months old.
3/ Test material was relatively fresh.
-------
CHAPTER III: SUMMARY OF DATA REQUIREMENTS AND DATA GAPS
A. Introduction
B. Table A - Generic Data Requirements
C. Table B - Product Specific Manufacturing-Use Products Data Requirements
D. Table C - Product Specific End-Use Product Data Requirements
A. Introduction
Applicants for registration of manufacturing-use and end-use
phosalone products must cite or submit the information identified as required
in the tables in this chapter. The tables applicable to end-use products
indicate whether the product to be tested is the technical grade or
formulation. Data generated on one formulation may be used to satisfy the data
requirement for a substantially similar formulation. Information on which
product specific data requirements are already met is available in the guidance
package.
Before each requirement is listed the section of the Proposed Guidelines which
describes the type of data and when the data are required to be submitted
[43 FR, 29696 of July 10, 1978; and 43 FR, 37336 of August 22, 1978; 45 FR,
72948 of November 3, 1980]. Justification for the test requirement is
provided in the Guidelines. A discussion of why data additional to those
already submitted are necessary, or why data normally required are not
necessary for this chemical, is explained in footnotes to the tables. The
data requirements specified are the minimum that will be required. Areas where
additional data may be required as the result of tiered testing are indicated.
19
-------
Table A: Phosalone
Generic Data Requirements: Environmental Fate (See Chapter V)
Guidelines
Citation
163.62-7(b)
163.62-7(c)
163.62-8(b)
163.62-8(c)
163.62-8(f )
163.62-8(g)
Name of Test
Hydrolysis
Photodegradation
Aerobic Soil
Metabolism
Anaerobic Soil
Metabolism
Microbial Metabolism:
(2) Effects of
Microbes on
Pesticides
(3) Effects of
Pesticides on
Microbes
Activated Sludge
Composition
Tech. or
Radiolabeled
Analytical Gr.
Tech. or
Radiolabeled
Analytical Gr.
Tech. or
Radiolabeled
Analytical Gr.
Tech. or
Radiolabeled
Analytical Gr.
Tech.
Tech.
Tech.
Does EPA Have Data Bibliographic Must Additional Data
to Partially or Citation be Submitted Under
Totally Satisfy FIFRA 3(c) (2) (B)?
this Requirement? If so, due when?
partially-/ Laurent et al., 000006067 yes/12 mo.
yes Ambrosi et al., 000006409 no
Ambrosi et al., 000006666
Laurent et al., 000006665
yes -/ no
no - yes/14 mo.
reserved-/ Ambrosi et al., 000006666
Dasmoras et al., 000006770
reserved-/ Ambrosi et al.r 00006667
reserved—
Metabolism
All data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
-------
I/ This data requirement has only partially been fulfilled. The guidelines require that studies be conducted
using two temperatures and two concentrations. Therefore, an additional hydrolysis study using a
concentration lower than 1.5 ppm and at a temperature other than 20 is needed to assess the fate of
phosalone in the water.
2/ ftmbrosi et al., 000006409
Ambrosi et al., 000006664
Ambrosi et al., 000006666
ftmbrosi et al., 005008305
Ambrosi et al., 005009356
Desmoras et al., 000006770
_3_/ The requirement for the submission of these data is currently being reserved, pending the review and
modification of the testing protocols.
-------
Table A: Phosalone
Generic Data Requirements: Environmental Fate (See Chapter V)
Guidelines
Citation
163.62-9
163.62-9(0)
Name of Test
Leaching
Volatility
Composition
Tech. or
Radiolabeled
Analytical Gr.
Tech. Grade
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
partially-/ -/
reserved—'
Bibliographic
Citation
Ambrosi et al., 000006663
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?*
yes/12 mo.
163. 62-9 (d)
163.62-10(b)
163.62-10(f)
Adsorpt ion/Desorption
Terrestrial Field
Dissipation:
(1) Field & Vegetable
Crops
(2) Tree Fruit & Nut
Crop Uses
Combination and
Tank Mix Field
Dissipation
Tech. or
Radiolabeled
Analytical Gr.
A representive
formulated
product
A representive
formulated
product
no
no
yes/12 mo.
yes/26 mo.
yes/26 mo.
All data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
I/ For terrestial noncrop users, orchard crop uses, the mobility of the test substance and its degradates
in soil shall be assessed either by soil thin-layer chroma tography , soil column, or batch equilibrium
(absorption/desorption) procedures.
2/ The rapid leaching study of parent material (phosalone) is valid, but the aged portion of the study is
incomplete. (Please refer to Chapter V for a detailed discussion). Therefore, data are still required.
_3_/ The vapor pressure is not known. When this data gap has been filled, an assessment can be made concerning the
need for a volitilization study.
4/ Not applicable in single active ingredient standards.
-------
Table A: Phosalone
Generic Data Requirements: Environmental Fate (See Chapter V)
Guidelines
Citation
163.62-10(g)
163.62-ll(b)
163.62-ll(d)
Name of Test
Long Term Field
Dissipation Study
Accumulation in
Rotational Crops
Fish Accumulation
Composition
-
Radiolabeled
Analytical Gr.
Followed by
Formulation
Tech. or
Radiolabeled
Analytical Gr.
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
reserved—
partially-/
partially-/
Bibliographic
Citation
-
Ambrosi et al., 000006664
Barrows, M.E., 000006109
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
yes/26 mo.
yes/26 mo.
163.62-12
Reentry
163.62-13
Disposal & Storage
A Representative
Formulated
Product
Tech. and All
Formulated Products
partially-/
reserved—
Khaak et al., 005003635
Leffingwell et al., 005007744
Leffingwell et al., 005007745
Popendorf et al., 005005243
Winterlin et al., 005001343
All data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
I/ The requirement for the submission of these data is currently being reserved pending the receipt and evaluation of
data on terrestial field dissipation. Consequently the absence of acceptable data does not constitute a data
gap.
_2/ Additional data from field studies are needed to identify residues accumulated by radishes, beans, potatoes, and
~ wheat planted as rotational crops in phosalone-treated fields. In addition, all studies specified in Section
163.62-ll(b) are needed for all other crops that may be planted in rotation with phosalone-treated crops. However,
this crop rotation restriction may be removed as discussed in Chapter V.
3/ An additional study, using a flow-through system and identifying radio-labeled residues, is needed to satisfy data
~ requirements in Section 163.62-11(d).
4/ Until the Guidelines and the reentry interval review is complete, the Agency intends to maintain the 24 hour
~ reentry interval as an interim measure. If the registrant wishes to appeal, interval data may be submitted to the
Agency to support a change. Please see Chapter V for a discussion.
5/ Guidelines for this Section have not been completed, consequently the absence of acceptable data does not constitute a data gap.
-------
Table A: Phosalone
Generic Data Requirements: Toxicology (See Chapter VI)
Guidelines
Citation
163.81-1
163.81-2
163.81-3
163.81-4
163.81-5
163.81-6
163.81-7
163.82-1
163.82-2
Name of Test
Acute Oral Toxicity
Acute Dermal Toxicity
Acute Inhalation
Toxicity
Primary Eye
Irritation
Primary Dermal
Irritation
Dermal Sensitization
Acute Delayed
Neurotoxicity
Subchronic Oral
Toxicity
Subchronic 21-Day
Dermal
Composition Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
Each Product yes
or Substantially
Similar Product
Ea. Prod, or yes
Substan. Sim. Prod.
Ea. Prod, or no
Substan. Sim. Prod.
Ea. Prod, or no—'
Substan. Sim. Prod.
Ea. Prod, or no
Substan. Sim. Prod.
Ea. Prod, or no
Substan. Sim. Prod.
Tech. Grade of A.I. no-/
Tech. Grade of A.I. yes
Tech. Grade of A.I. no
Bibliographic Must Additional Data
Citation be
Dubost et al., 000006643
Fournel et al., 000006716
Pasquet et al . , 005007746
Rivett and Davies, 000006697
Dubost et al., 000006643
Pasquet, 005007746
_
-
_
-
-
Donoso et al., 000006203
Fournel et al., 000006684
Jones et al., 000006205
Noel et al., 000006111
Woodward et al. 000006202
-
Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
no
no
yes/6 mo.
yes/6 mo.
yes/6 mo.
yes/6 mo.
yes/12 mo.
no
yes/12 mo.
All data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
V There are data available for the EC formulation. The registrant may use this study (Horn et al., 1965, MRID 000006690)
to fulfill this requirement. However, this places the manufacturing-use product in Toxicity Category I. In this event
the Agency would require changes in the label, including a statement specifying the use of protective clothing.
2/ Data are required, because phosalone caused cholinesterase depression.
-------
Table A: Phosalone
Generic Data Requirements: Toxicology (See Chapter VI)
Guidelines Name of Test
Citation
163.84-2
through—4
163.85-1
Mutagenicity
Metabolism and
Pharmacodynamics
Composition
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
Bibliographic
Citation
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
163.82-5
163.83-1
163.83-2
163.83-3
163.83-4
Subchronic
Neurotoxicity
Chronic Feeding
Tbxicity
Oncogenicity
Teratogenicity
Reproduction
Tech. Grade of A.I. yes
lech. Grade of A.I. yes
Tech. Grade of A.I. yes
Tech. Grade of A.I. yes
Tech. Grade of A.I. yes
/
Woodward et al., 000006695
Vfoodward et al. 000006202
Rhone-Poulenc, Inc. GS0027021
Woodard et al. , 000006202
Khera et al., 005008254
Pasquet and Buisson, 000006110
Benazet and Cartier, GS0027020
Collins and Ings, 00006977
Desmoras et al., 000006715
Jones et al., 00006204
Khera et al., 05008254
no
no
no
no
no
Tech. Grade of A.I.
yes
Analytically
Pure Radioactive
Grade
yes
Pasquet and Buisson, 00006110
Benazet and Cartier GS0027020 no
Collins & Ings, 000006977
Desmoras et al., 000006715
Goldenthal et al., GS0027019
Jones et al., 000006204
Khera et al., 005008254
Pasquet and Buisson, 000006110
Rhone-Poulenc, Inc., GS0027021
Wbodard et al. 000006202
Collins and Ings, 000006977 no
Craine, 000006972, 000006973,
and 000006975
Desmoras et al. 000006715
Fournel et al., 000006716
Pasquet et al., 005007746
All data requirements are current as of August, 1981. Refer to the guidance package for updated requirement
-------
Guidelines
Citation
Table A: Phosalone
Generic Data Requirements: Residue Chemistry (See Chapter VII)
Name of Test
Composition
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
Bibliographic
Citation
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If So, due when?
Metabolism in Plants
Metabolism in Animals
Analytical Methods
Residue Data:
Crops
Residue Data:
Processed Crops
Residue Data:
Milk & Meat
Storage Stability
V
!/
V
V
V
V
I/
yes
yes
yes
yes
yes
yes
yes
2/ no
Desnoras et al., 000006715 no
Craine, E.M., 000006974
3/ no
4/ no
5/ no
6/
Desmoras et al., 000006968 no
Klisenko and Pis'mennaya, 005014548
Laurent et al., 000006698
Rhodia, Inc., 000006113
All data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
I/ Residue of Active Ingredient and its Metabolites Which may be of Toxicological Concern.
y Ainbrosi et al. 000006125
Desnoras et al. 000006791
Desnoras et al. 000006386
FAO Working Party 005013895
Kbvaleva, E.S. 005014688
Nalbanyan, R.A. 005016356
Societe des Usines 000006675
Chimiques Rhone - Poulenc
Winterlin et al. 005009309
-------
3_/ Desmoras, J. 005016979
Guardigli, A. 000006383
Guardigli, A. 000006703
Guardigli, A. 000006129
Guardigli, A. 000006762
Guardigli, A. 000006105
Guardigli, A. GS0027010
Guardigli and Melkesian 000006083
Guardigli et al. 005008180
Guardigli et al. 000006678
Laurent et al. 000006700
Societe des Usines 000006701
Chimiques Rhone-Poulenc
4/ Almond nutmeats and almond hulls
Guardigli, A. 000006358
Brazil nuts, bush nuts, butternuts, cashews, chestnuts, filberts, hazelnuts, hickery nuts, macadamia nuts,
pecans and walnuts (except almonds)
Residue data were submitted for pecans and walnuts under the provision in CFR 40, 180.34 f. i.e. "It may be
possible to make a reliable estimate of negligible residues of pesticide chemicals to be expected on each
commodity in a designated grouping on the basis of data on a representative number of commodities listed in
the following designated groups." Accordingly the submitted data for pecans and walnuts are to be extended to
the other nutcrops mentioned above.
Pecans
Guardigli, et al. 000006511
Walnuts
Guardigli, et al. 000006511
Apples
Desmoras et al. 000006707
Guardigli, A. 000006388
Guardigli, A. 000006783
Guardigli, A. 000006711
Guardigli, A. 000006084
Rhodia, Inc. 000006712
-------
Pears
ro
CO
Guardigli, A., 000006714
Guardigli, A. 000006392
Grapes
Desiroras et al. 000006707
Guardigli, A. 000006390
Guardigli, A. 000006713
Guardigli, et al. 000006480
Laurent et al. 000006708
Citrus Fruit
Guardigli, A. GS0027014
Guardigli, A. GS0027015
Guardigli, A. GS0027016
Artichokes
Henckler, P. 000006964
Societe des Usines Chiniques GS0027009
Khone-Poulenc
Potatoes
Guardigli, A. 000006395
Guardigli, et al. 000006576
Apricots
Henckler et al. 000006483
US EPA GS0027006
Cherries
Guardigli, A. 000006389
Henckler et al. 000006484
US EPA GS0027006
-------
Nectarines
ro
to
Henckler et al.
IB EPA
Peaches
Guardigli, A.
Henckler et al.
Rhodia, Inc.,
Chipinan Division
Plums_( fresh prunes)
Rhodia, Inc., Chipman
Division
Henckler et al.
Guardigli, A.
V Dried. Raisins
Guardigli, et al.
Dried^jSrape Pomace
Dennis, S.
Dried _Apple Pomace
Guardigli, A.
Rhodia, Inc.
Dried Citeu£[_Pulp
Guardiglia, A.
Prunes
Guardigli, A.
Henckler, et al.
000006485
GS0027006
000006391
000006486
GS0027025
GS0027025
000006487
000006769
000006480
000006069
000006068
000006357
GS0027016
000006769
000006487
-------
Dried tea
Desmoras, et al. 000006209
Rhodia, Inc. 000006210
Crouch, R.V. 000006735
6/ Meat, milk, poultry and eggs.
Collins et al. 000006978
Craine, E.M. 000006972
Craine, E.M. 000006973
Craine, E.M. 000006974
Craine, E.M. 000006975
Guardigli, A. 000006971
Posner, S. 000006761
Posner, S. 000006792
Rhodia, Inc. 000006120
Rhodia, Inc. 000006123
Rhodia, Inc. 000006717
Tbtman et al. 000006073
Tbtman et al. 000006071
-------
Guidelines
Citation
Table A: Phosalone
Generic Data Requirements: Ecological Effects (See Chapter VIII)
Name of Test
Composition
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
Bibliographic
Citation
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
163.71-1
163.71-2
163.71-3
163.71-4
163.71-5
163.72-1
163.72-2
163.72-3
163.72-4
163.72-5
163.72-6
Avian Single-Dose Oral
^50
Avian Dietary !£,-„
Mammalian Acute Toxicity
Avian Reproduction
Simulated and Actual Field
Testing for Mammals & Birds
Fish Acute LC5Q
Acute Toxicity to Aquatic
Invertebrates
Acute Toxicity to Estuarine
& Marine Organisms
Embryolarvae & Life-
cycle Studies of Fish &
Aquatic Invertebrates
Aquatic Organism Toxicity
& Residue Studies
Simulated or Actual
Field Testing for
Aquatic Organisms
Tech.
Tech.
Tech.
Tech.
no
no
reserved—'
reserved—'
reserved—'
no
no
reserved—'
reserved-
reserved—'
reserved—
yes/11 mo.
yes/11 mo.
I/
I/
V
yes/11 mo.
yes/11 mo.
V
V
V
V
These data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
I/ The requirement for the submission of the data is currently reserved, pending the results of the outstanding
~ data.
-------
Generic Data Requirement!: 'Ecologica?eEffects (See Chapter VIII)
Guidelines
Citation
163.122-1
163.122-1
163.122-2
163.122-2
Name of Test
Seed Germination
Vegetative Vigor
Aquatic Macrophytes
Algae
Composition
Technical
Technical
Technical
Technical
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
no
partially^
no
no
Bibliographic
Citation
.
y
-
-
Must Additional Data
be Submitted Under
FIFRA 3(C)(2)(B)?
If so, due when?
yes/26 mo.
yes/26 mo.
yes/26 mo.
yes/26 mo.
All data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
_!/ The data requirement has been partially filled by the following studies in aggregate:
Ciarletta et al.
Delay, D.L.
Delay, D.L.
Delay, D.L.
Eckenrode et al.
Ishitani et al.
Knobel, H. and Rock, G.
Knobel, H. and Rock, G.
Lillie, D.T.
Lillie, D.T. and Carman,
Lillie, D.T. and Carman, G.
Preiser, F.A. and Taschenberg, E.F.
Rhod ia, Incorporated
Smyth et al.
Smyth, E.P. and Hoyt, S.
Smyth, E.P. and Jones, S.C.
Spencer, W.T. and Hofmaster, R.N.
Szabo, J. and Walls, A.
Szabo, J. and Sleesman, J.P.
G.
Wang,
Wang,
Wang,
Wang, D.
Wang, D.
D.
D.
D.
000014256
000006528
000006534
000006569
005015711
005006342
000006938
000006939
000006430
000006747
000006748
000006479
000006733
000006243
000006639
000006283
000006738
000006592
000006593
000006114
000006115
000006289
000006477
000006145
To complete the vegetative vigor data requirement, data are needed on the effects of phosalone on raonocot plants.
-------
Guidelines
Citation
163.61-3
163.61-4
Table B; Phosalone
Product Specific Manufacturing-Use Products Data Requirements: Product Chemistry (See Chapter IV)
Name of Test
Product Identity
& Disclosure of
Ingredients
Description of
Manufacturing
Process
Composition
Each Product
Each Product
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
yes
yes
Bibliographic
Citation
Must Additional Data"
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
yes!/
yes—/
163.61-5
163.61-6
163.61-7
Discussion on
Formation of
Unintentional
Ingredients
Declaration &
Certification of
Ingredients Limits
Product Analytical
Methods & Data
Each Product
Each Product
Each Product
yes
yes
yes
2/
no
These data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
I/ This requirement must be fulfilled by each applicant. Data from other applicants may not be cited. Therefore,
~ even if the requirement has been partially or completely fulfilled for some products, no references are given.
This requirement must be filled at the time of registration. However, this requirement has been fulfilled for
current registrations. Please refer to Chapter IV for a discussion of the data.
2/ Brun et al., 005005128
Guardigli, A., 000006640
Guardigli, A., 000006170
Henckler, R., 000006107
Laurent, M., 000006645
Maharova et al., 0050011351
Societe des Usines Chemiques Rhone -
Societe des Usines Chemiques Rhone -
Societe des Usines Chemiques Rhone -
Poulenc, GS0027009
Poulenc, 000006398
Poulenc, 000006943
-------
Table B: Phosalone
Product Specific Manufacturing-Use Products Data Requirements: Product Chemistry (See Chapter IV)
Guidelines
Citation
163
,61-8(c)
Name of Test
(1)
Color
Composition
Does EPA Have Data Bibliographic
to Partially or Citation
Totally Satisfy
this Requirement?
Technical Grade of
yes —
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
yesi/
Active Ingredient
163
163
163
163
163
163
163
163
163
163
.61-8(c)
.61-8(c)
.61-8 (c)
.61-8(c)
.61-8(c)
(2)
(3)
(4)
(5)
(6)
.61-8(c)(7)
.61-8(c)
(8)
.61-8(c)(9)
.61-8(c)
.61-8(c)
(10)
(ID
Cdor
Melting Point
Solubility
Stability
Cctanol/Water
Partition Coefficient
Physical State
Specific Gravity
Boiling Point
Vapor Pressure
PH
Tech.
Tech.
Tech.
Tech.
Tech.
Tech.
Tech.
Tech.
Tech.
Tech.
Grade
Grade
Grade
Grade
Grade
Grade
Grade
Grade
Grade
Grade
of
of
of
of
of
of
of
of
of
of
A.
A.
A.
A.
A.
A.
A.
A.
A.
A.
I.
I.
I.
I.
I.
I.
I.
I.
I.
I.
yes —
yes —
partially-/ —
yes —
yes
yes ~~~~
no —
4/ —
no —
v —
yes—
yesi/
ves^/
yesi/
yes-
yes—
yes—'
no
yes^/
no
These data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
I/ These requirements must be fulfilled by each applicant. Data from other applicants may not be cited. Therefore,
even if the requirements have been partially or completely fulfilled for some products, no references are given.
These requirements must be filled at the time of registration. However, this requirement has been fulfilled for
current registrations. Please refer to Chapter IV for a discussion.
2/ This requirement must be fulfilled by each applicant. Data from other applicants may not be cited. Therefore, even
~~ if the requirement has been partially or completely fulfilled for some products, no references are given. This
requirement must be filled at the time of registration or reregistration.
3/ Since phosalone is practically insoluble in water, the solubility for other solvents i.e. benzene, dioxane, methylene
~~ chloride, methanol, ethanol, choroform, xylene etc. in terms of g/lOOml of solvent at 20 C or in ppm should be
reported to fulfill this requirement for current registrations.
-------
4/ This is not needed, because phosalone is a solid.
5/ Phosalone is practically insoluble in water (1.7 ppm at 20°C); therefore, no pH data are required.
OJ
in
-------
Table B: Phosalone
Product Specific Manufacturing-Use Product Data Requirements: Product Chemistry (See Chapter IV)
Guidelines
Citation
Name of Test
Composition
OJ
en
163.61-8(c)(12) Storage Stability
163.61-8(c)(13) Flammability
163.61-8(c)(14) Oxidizing/Reducing
Action
163.61-8(c)(15) Explosiveness
163.61-8(c)(16) Miscibility
163.61-8(c)(17) Viscosity
Coefficient
163.61-8(c)(18) Corrosiveness
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
Bibliographic Must Additional Data
Citation be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
Each Manufacturing- yes
Use Product
Each Manufacturing - no
Use Product
Each Manufacturing- yes
Use Product
Each Manufacturing- no
Use Product
Each Manufacturing- no
Use Product
Each Manufacturing- no
Use Product
Each Manufacturing- no
Use Product
yes—'
yes2/
yes2/
yes!/
yes—'
yes2/
These data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
I/ This requirement must be fulfilled by each applicant. Data from other applicants may not be cited. Therefore, even if
~ the requirement has been partially or completely fulfilled for some products, no references are given.
This requirement must be filled at the time or registration. However, this requirement has been fulfilled for
current registrations. Please refer to Chapter IV for a discussion of the data.
2/ This requirement must be fulfilled by each applicant. Data from other applicants may not be cited. Therefore,
~ even if the requirement has been partially or completely fulfilled for some products, no references are given.
This requirement must be filled at the time or registration or reregistration.
-------
Table C: Phosalone
Product Specific End-Use Products Data Requirements: Product Chemistry (See Chapter IV)
Guidelines
Citation
Name of Test
Composition
163.61-3
163.61-4
Product Identity
& Disclosure of
Ingredients
Description of
Manufacturing
Process
Each Product
Each Product
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
yes
no
Bibliographic
Citation
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
yesi/
yes!/
163.61-5 Discussion on
Formation of
Unintent ional
Ingredients
163.61-6 Declaration &
Certification of
Ingredients Limits
163.61-7 Product Analytical
Methods & Data
Each Product
Each Product
Each Product
yes
yes
yes
3/
yes*/
no
These data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
I/ This requirement must be fulfilled by each applicant. Data from other applicants may not be cited. Therefore, even
if the requirement has been partially or completely fulfilled for some products, no references are given. These
requirement must be filled at the time of registration. However, this requirement has been fulfilled for current
registrations. Please refer to Chapter IV for a discussion of the data.
2/ This requirement must be fulfilled by each applicant. Data from other applicants may not be cited. Therefore, even
~ if the requirement has been partially or completely fulfilled for some products, no references are given. This
requirement must be filled at the time or registration or reregistration.
3/ Brun et al., 05005128
Guardigli, A., 00006640
Guardigli, A., 00006170
Henckler, P., 00006107
Laurent, M. 00006645
Makarova et al., 05011351
Societe des Usines Chemiques Rhone-Poulenc, 00006398
Societe des Usines Chemiques Rhone-Poulenc, GS0027009,
Societe des Usines Chemiques Rhone-Poulenc, 00006943
-------
Table C: Phosalone
Product Specific End-Use Products Data Requirements: Product Chemistry (See Chapter IV)
GO
co
Guidelines
Citation
163.61-8(c)(l)
163.61-8(c)(2)
163.61-8(c)(7)
163.61-8(c)(8)
163.61-8(c)(ll)
163.61-8(c)(12)
163.61-8(c)(13)
163.61-8(c)(14)
163.61-8(c)(15)
163.61-8(c)(16)
163.61-8(c)(17)
163.61-8(c)(18)
Name of Test
Color
Odor
Physical State
Specific Gravity
pH
Storage Stability
Flammability
Oxidizing/Reducing
Action
Explos iveness
Miscibility
Viscosity Coefficient
Corros iveness
Composition
Each
Each
Each
Each
Each
Each
Each
Each
Each
Each
Each
Each
Product
Product
Product
Product
Product
Product
Product
Product
Product
Product
Product
Product
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
no
no
no
no
no
no
no
no
no
no
no
no
Bibliographic Must Additional Data
Citation be Submitted Under
FIFRA 3(c)(2)(B)?
If So, due when?
yesi/
yesi/
— yes—
yesi/
yes^-/
yes^
yes^
yesi/
yes—
yes^/
yes—
yes^/
These data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
I/ This requirement must be fulfilled by each applicant. Data from other applicants may not be cited. Therefore, even if
the requirements have been partially or completely fulfilled for some products, no references are given.
This requirement must be filled at the time of registration or reregistration.
-------
Table C: Phosalone (Emulsifiable Concentrate)
Product Specific End-Use Product. Data Requirements: "toxicology (See Chapter VI)
Guidelines
Citation
163.81-1
163.81-2
163.81-3
163.81-4
163.81-5
163.81-6
Name of Test
Acute Oral Toxicity
Acute Dermal Toxicity
Acute Inhalation
Toxicity
Primary Eye
Irritation
Primary Dermal
Irritation
Dermal Sensitization
Composition
Each Product
or Substantially
Similar Product
Ea. Prod, or
Substan. Sim. Prod
Ea. Prod, or
Substan. Sim. Prod
Ea. Prod, or
Substan. Sim. Prod
Ea. Prod, or
Substan. Sim. Prod
Ea. Prod, or
Substan. Sim. Prod
Does EPA Have Data
to Partially or
Totally Satisfy
this Requirement?
yes
yes
•
yes
•
yes
•
no
•
no
•
Bibliographic Mi
Citation bt
F:
ii
Rivett and Davies, 000006697
Scott and Beliles, 000006688
US EPA, GS0027004
US EPA, GS0027006
Horn et al., 000006689
Beliles, 000006981
Horn et al., 000006690
-
_
Must Additional Data
be Submitted Under
FIFRA 3(c)(2)(B)?
If so, due when?
no
no
no
no
yes/6 mo.
yes/6 mo.
All data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
-------
Table C: Phosalone (Wettable Powder)
Product Specific End-Use Product Data Requirements: Toxicology (See Chapter VI)
Guidelines Name of Test
Citation
163.81-1 Acute Oral Toxicity
163.81-2 Acute Dermal Toxicity
163.81-3 Acute Inhalation
Toxicity
163.81-4 Primary Eye
Irritation
<=> 163.81-5 Primary Dermal
Irritation
163.81-6 Dermal Sensitization
Composition Does EPA Have Data Bibliographic Must Additional Data
to Partially or Citation be Submitted Under
Totally Satisfy FIFRA 3(c) (2) (B)?
this Requirement? If so, due when?
Each Product yes US EPA, GS0027005 no
or Substantially US EPA, GS0027003
Similar Product
Ea. Prod, or yes^ Horn et al., 000006689 no
Substan. Sim. Prod.
Ea. Prod, or yes-^ Beliles, 000006981 no
Substan. Sim. Prod.
Ea. Prod, or no - yes/6 mo.
Substan. Sim. Prod.
Ea. Prod, or no - yes/6 no.
Substan. Sim. Prod.
Ea. Prod, or no - yes/6 mo.
Substan. Sim. Prod.
All data requirements are current as of August, 1981. Refer to the guidance package for updated requirements.
I/ The data for the EC formulation will fulfill this data requirement for the WP formulation.
-------
CHAPTER IV: PRODUCT CHEMISTRY
A. Chemistry Profile
B. Data Gaps
A. Chemistry Profile
The data concerning product chemistry, which fulfill or partially fulfill
Agency guideline requirements are discussed below. They are grouped by topic,
corresponding to specific sections in the guidelines.
1. Chemical Identity
Phosalone is the accepted common name for 0,0-diethyl S-[(6-chloro-2-
oxobenzoxazolin-3-yl-)methyl] phosphorodithioate as determined by the American
National Standards Institute (1967). Trade names for phosalone include
Zolone®, Rubitox®, RP-11974 and NPH-1091.
The molecular weight of phosalone is 367.82. The chemical formula is
C12H15PS2N°4C1 (Sauli' M" 1975' MRID 005017962).
No additional data are required with regard to phosalone's chemical identity
for current manufacturing-use and end-use product registrations.
2. Manufacturing Process
Rhodia, Inc., Agricultural Division, Monmouth Junction, New Jersey, is the
sole registrant for phosalone in the United States. It is manufactured by
Rhone-Poulenc, Inc. in Paris, France.
Sauli (1975, MRID 005017962) describes a French patent in which phosalone is
synthesized in a single phase condensation process of an alkali salt or
an ammonium salt of 0,0-diethyldithiophosphoric acid, formaldehyde and 6-chloro-
benzoxazolone in the presence of methane sulphonic acid.
A complete description of the manufacturing process has been supplied to the
Agency. Details of this process, however, are considered by the Agency to be
trade secret information and will not be provided within this standard.
No further information is required for the current manufacturing-use product.
No data are available for the end-use products.
3. Formation Of Unintentional Ingredients
Detailed information is available concerning unintentional impurities which
may be present in technical phosalone. Like the manufacturing
process, this information is considered trade secret and will not be provided
within this standard.
41
-------
The data which have been submitted fulfill this data requirement for the
current manufacturing-use and end-use product registrations.
4. Percentage Of Active Ingredient in Pesticide Products
A confidential statement of formula by Rhodia, Inc. reveals that technical
phosalone contains 94 percent active ingredient. The remaining six
percent consists of manufacturing impurities.
Phosalone is sold as an EC containing 34.4 percent active ingredient (three
pounds active ingredient per gallon) and as a WP containing 25 percent active
ingredient.
The information concerning the remaining ingredients for the technical and
formulated products, as well as the nature of these formulations, is considered
trade secret and, hence, will not be described within this standard.
No additional data are required for the current manufacturing-use and end-use
product registrations.
5. Product Analytical Methods and Data
Analytical methods for the identification and quantification of phosalone in
the technical material and formulated end-use products have been submitted.
Methods for the analysis of unintentional impurities have also been submitted
and are considered to be adequate.
The methods consist of Gas-Liquid Chromatography with electron capture
detection and various Thin Layer Chromatographic procedures (Guardigli, A.,
1968, MRID 000006170; Guardigli, A., 1969, MRID 000006640; Henckler, P., 1973,
MRID 000006107; Societe des Usines Rhone-Poulenc, Inc., 1973, GS0027009;
Societe des Usines Chimiques Rhone-Poulenc, 1966, MRID 000006398).
Infrared (IR) and Ultraviolet (UV) spectra for phosalone have also been
submitted (Societe des Unines Chemiques Rhone-Poulenc, 19??, MRID 000006943).
A colorimetric method including IR and UV spectrometry is detailed in Laurent
(1964, MRID 000006645.) An alternate method for phosalone identification
consists of a procedure combining thin-layer chromatography and fluoresence
spectroscopy (Brun et al., 1973, MRID 005005128). Another method for the
determination of phosalone entails the application of iodometric titration
(Makarova et al., 1972, MRID 005011351).
These various analytical methods have been reviewed by the Agency and have been
found to fulfill all data requirements with respect to analytical methodology
for current manufacturing-use and end-use product registrations.
42
-------
6. Physical and Chemical Properties
The data which are available concerning these properties for manufacturing-use
phosalone are described below. Unless otherwise indicated these data
requirements are considered fulfilled for the current manufacturing-use
products. There are no data available to describe the formulated products.
a. Color
The color is white (Rhodia, Inc., 19??, MRID 000006651).
b. Cdor
The odor is reminiscent of garlic (Rhone-Poulenc, Inc., 1966,
MRID 000006172).
c. Melting Point
The melting point is 45-47°C (Rhodia, Inc., 19??, MRID 000006651).
d. Solubility
At 25°C (Rhodia, Inc., 19??, MRID 000006113) phosalone is practically
insoluble in water, cyclohexane and petroleum ether. At 20 C (Laurent
et al., 1975, MRID 000006067) phosalone has low water solubility,
approximately 1.7 ppm . Freed et al. (1979, MRID 005018633) reported the
solubility as 2.15 ppm. It is soluble in benzene, dioxane, ethanol,
methylene chloride, methanol, acetone, chloroform, acetonitrile, xylene
and isophorone.
The proposed registration guidelines state in Section 163.61-8(4) that
solubility data are required in g/100 ml of solvent at 20°C (68°F) or
in terms such as ppm (mg/kg).
Accordingly, the above solubility data, with the exception of solubility
in water, are inadequate and further data are required.
e. Stability
Technical phosalone is an organophosphorus compound relatively stable to
heat (up to 100°C) and acid media. Hydrolysis occurs under alkaline
conditions, but more slowly than for many other organophosphorus
insecticides (Desmoras et al., 19??, MRID 000006968; Rhodia, Inc., 19??,
MRID 000006113.)
43
-------
The rate of decomposition is a function of exposure to UV light and is as
follows:
The constant of reaction rate under UV light is 0.0081/sec and the
half life is 86 minutes (Klisenko, M.A. and Pis'mennaya, M.V., 1973,
MRID 005014548).
f. Octanol/Water Partition Coefficient
The logarithm of the octanol/water partition coefficient at 20 C is 4.30
(Freed et al., 1979, MRID 005018633).
g. Physical State
The physical state is crystalline (USA Standards Institute, 1967,
MRID 000006668).
h. Vapor Pressure
The vapor pressure of phosalone at 20 C is negligible; however, specific
figures are not available. The phosalone concentration of a saturated
atmosphere is <0.01 mg/m (Desmoras et al., 19??, MRID 000006968).
The registrant is required to supply the exact figures for vapor pressure
in torr or mm Hg. Thus, the data are required.
i. pH
Since phosalone is practically insoluble in water, no pH data are required.
j. Storage Stability
Results of stability studies on a technical lot of phosalone stored for
six months and also for two years show that phosalone is very stable under
normal laboratory conditions for a period of two years without risk of
notable degradation (Laurent et al., 1965, MRID 000006698). The stability
of bulk or formulated products is excellent. ISb appreciable loss in
activity was observed in either normal temperature storage trials or from
a month of accelerated storage at 50° (Rhodia, Inc., 19??,
MRID 000006113).
k. Oxidizing or Reducing Action
Under acidic conditions, no significant degradation of phosalone takes
place. Under alkaline conditions, phosalone is not stable and at 20°C
exhibits a half life of about nine days (Laurent et al., 1975,
MRID 000006067).
44
-------
B. Data Gaps
Please refer to the data charts in Chapter III for the requirements, which
need to be fulfilled.
45
-------
CHAPTER V: ENVIRONMENTAL FATE
A. Use Summary
B. Environmental Fate Profile
C. Exposure Profile
D. Data Gaps
A. Use Summary
Phosalone is an insecticide/miticide federally registered for commercial use
to control a variety of insect and mite pests on fruit, nut, vegetable, and
ornamental crops. Approximately 80 percent of phosalone applications are made
on pecans in the southeastern and southwestern states. Other major application
sites are for apples in the eastern, western and north central states, and for
grapes in California and Arizona.
Phosalone is formulated into a 25 percent active ingredient wettable powder
formulation used predominantly on apples and grapes, and a 34.4 percent active
ingredient emulsifiable concentrate formulation used predominantly on pecans,
apples, and grapes. Application rates for these crops range from 0.25-1.0
pounds active ingredient per 100 gallons of water (1.0-4.0 pounds active
ingredient per acre.) Both formulations are mixed with water and applied as
foliar applications with aircraft and ground equipment, including air-blast
sprayers, hydraulic sprayers fitted with a single wand (gun) or boom, and
others. The type of equipment is determined by the site and equipment
availability.
Approximately 1.5-2 million pounds active ingredient are imported annually
from France. No phosalone production is reported in the United States.—
B. Environmental Fate Profile
The environmetal fate studies which fulfill or partially fulfill the data
requirements are discussed below. They are grouped by topic to correspond to
specific sections in the Guidelines.
1. Hydrolysis
Phosalone is stable over a pH range of 5-7, but is hydrolyzed at pH 9 with a
half-life of nine days. In a hydrolysis study at pH 9, more than 15 distinct
degradation products were found after four weeks. No single degradation
product exceeded 10 percent of the applied phosalone. Only four degradation
products were identified: phosalone-oxon, 6-chloro-benzoxazolone, 3-amino-7-
chloro-2-phenoxazone, and its precursor, 2-amino-5-chlorophenol (Laurent et
al., 1975, MRID 000006067).
This study, however, only partially fulfills the hydrolysis data requirement.
The guidelines require two temperatures and two concentrations to fulfill this
46
-------
data requirement. Therefore, a hydrolysis study using a concentration lower
than 1.5 ppm and at a temperature other than 20 C is needed to fully assess
the fate of phosalone in the water.
V No confidential business information has been used to arrive at this EPA
estimate of production volume.
2. Photolysis
Phosalone degrades in irradiated water and soil. The data indicate half-lives
of 15-20 minutes and about one day, respectively, for water and soil. In
irradiated water, approximately 20 degradation products have been isolated,
with hydroxyl-phosalone being the major degradation product. Carbon dioxide,
6-chlorobenzoxazolone, and phosalone-oxon, were identified as minor degradation
products. Aout 97 percent of the applied phosalone degraded in nonsterile
irradiated soil after one month. Chly 30 percent degraded in sterile
clay loam soil under light, and 15 percent degraded in the dark. Dechlorinated
phosalone and the oxygen analogue were the major degradation products found in
irradiated soil, and carbon dioxide was a minor product of photolysis (Anbrosi
et al., 1974, MRID 000006409; Mbrosi et al., 1977, MRID 000006666; Laurent et
al., 1977, MRID 000006665).
These studies fulfill the data requirement pertaining to the photodegradation
of phosalone.
3. Aerobic Soil Metabolism
Phosalone half-lives in soil metabolism studies ranged from less than one day
(type of soil unidentified) to seven days (Beauce soil). Identified metabolites
were phosalone-oxon, 6-chlorobenzoxazolone, diethyldithiophosphoric acid,
diethylthionophosphoric acid, bis-0,0- diethylthionophosphoryl disulfide, 0,0-
diethyl thiophosphonyl disulfate, 0,0-diethylphosphonyl disulfate, and 3-amino-7-
chloro-2-phenoxazone. The following degradation products were also rapidly
degraded in soil: dechlorinated phosalone, phosalone-oxon,
6-chlorobenzoxazolone, and 3-amino-7-chloro-2-phenoxazone. Neither identified
nor unidentified polar and nonpolar extractable metabolites accumulated in
soil. Uhextractable radiolabeled residues rapidly accumulated to 70-90 percent
of the applied C phosalone under aerobic and flooded (semi-aerobic)
conditions. The unextractable residues were associated primarily with the
fulvic acid fraction. Ihder aerobic conditions, slightly less than 10 percent
of the applied C phosalone was lost as carbon dioxide within one
month (Anbrosi et al., 1974, MRID 000006409; Anbrosi et al., 1977, MRID
00006664; Mibrosi et al., 1977, MRID 000006666; Ambrosi et al., 1977, MRID
005009356; /mbrosi et al., 1978, MRID 005008305; Desuoras et al., 1975, MRID
000006770.
These studies meet guideline requirements, fbwever, the unextractable residues
interfere with development of a metabolic pathway. For example, before
47
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degradates are formed, the parent, and possibly some metabolites, are
unextractable. Usually from 60 to 90 percent of total phosalone is
unextractable, but is present in the soil and taken up by rotational crops.
These studies adequately characterize the aerobic soil metabolism of phosalone
and fulfill all data requirements.
4. Microbial Metabolism: Effects of Microbes on Pesticides
Microbial metabolism appears to be the primary mechanism responsible for
phosalone degradation in soil, accounting for 60 to 86 percent of its
degradation during a two or four week period. The organisms responsible for
the degradation, however, have not been identified (Ambrosi et al., 1977, MRID
000006666 and Desmoras et al., 1975, MRID 000006770).
The above data partially fulfill Agency requirements by demonstrating the
role of microbial metabolism on phosalone degradation. ND data are, however,
available on the identity of the organisms responsible for phosalone
degradation.
Despite the noted deficiency, the requirement for the submission of the
additional data is currently being reserved. The absence of
acceptable data within this topic does, therefore, not constitute a data gap.
5. Microbial Metabolism: Effects of Pesticides on Microbes
Limited data suggest that phosalone has variable effects on microbes. The
degradation of radiolabeled cytosine, glucose, glycine, guanine, phenylalanine,
and urea in soil was only temporarily inhibited by phosalone treatment at 10
and 100 ppn. At 1 ppn phosalone had no effect on soil dehydrogenase activity
over an eight day period, whereas at 10 ppn activity was inhibited by 20
percent. Soybean nodule formation by Rhizobium japonicum was not inhibited by
phosalone at _< 100 ppm. Phosalone treatment of soil at 1 and 10 ppm enhanced
oxygen consumption over a six hour period. Preliminary data also indicate that
nitrification and the growth of bacteria may be slightly inhibited by
phosalone (Anbrosi et al., 1976, MRID 000006667).
These data are not sufficient to satisfy this data requirement. Rarther
information on the effects of phosalone on important soil microbial functions
such as oxygen consumption, nitrification, denitrification, nitrogen fixation,
and microbial degradation of starch and protein is needed. This
requirement, like the preceding, is currently being reserved. Consequently,
the absence of acceptable data within this topic does not constitute a data gap.
48
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6. Leaching
Phosalone ( C radiolabeled) did not leach from columns of imaged soils
loamy sand, sandy loam, clay loam, and silt loam (Anbrosi et al., 1975,
MRID 000006663). The rapid leaching study of parent material (phosalone) is
valid, but the aged portion of the study is incomplete. For example, the
column was not leached long enough (only three days) and the identification of
metabolites was not reported. Also, the method for identification of
metabolites was not mentioned. The aged soil should be leached for more than
30 days and metabolites determined. These deficiencies consistute a data gap
in the (aged) leaching study.
7. 'Volatility
The vapor pressure of phosalone is not known. Vhen this data gap is filled, an
assessment can be made concerning the need for a volatilization study.
8. Accumulation in Rotational Crops
The current use pattern indicates that phosalone is used to treat potatoes and
artichokes as field crops. Artichokes are perennials and are not rotated with
any other crop; however potatoes are rotated with several other field crops.
Data from rotational crop studies under greenhouse conditions indicate that
phosalone and/or its metabolites can accumulate in radishes, beans, potatoes,
and wheat planted 1.5 to 5.5 months after soil treatment with phosalone at 3
ppm (Ambrosi et al., 1977, MRID 000006664).
Due to the appearance of phosalone residues in greenhouse crops, field studies
are required to determine if residues would occur under actual use conditions.
In addition, all studies specified in Section 163.62-ll(b) are needed for all
other crops identified by the registrant that may be planted in rotation with
phosalone-treated crops.
If the registrant does not wish to have a rotational crop restriction on a
phosalone product, one of the following must be done:
a. Supply environmental fate data supporting a rotation interval which
does not result in a pesticide residue in the rotated crops; or
b. Obtain a tolerance for the nontarget crop (46 FR 3018); or
c. Cbtain an exemption from a tolerance for the nontarget crop.
In the interim a label amendment restricting phosalone use in crop rotation
49
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programs will be required. (See Chapter II for for a more detailed
discussion).
9. Fish Accumulation
Maximum bioaccemulation factors for catfish, crayfish, bluegill, and rainbow
trout were about 31, 21, 16. and 16, respectively following exposure at
<0.3 to 0.99 ug/liter of [ C]phosalone over 28 days in a static system.
Residue levels in edible tissues declined to undetectable levels (<3 ppb)
between the 28th and 3rd day of exposure. Depuration of residues in nonedible
tissues was complete by day seven of the depuration period for all species
tested. Therefore, [ C]phosalone appears to exhibit a low bioaccunulation
potential in fish (Barrows, M.E., 1975, MRID 000006109).
Two exposure systems are required by the 1978 guidelines. Therefore, an
additional study using a flow-through system and identifying radiolabeled
residues is needed to satisfy this data requirement.
10. Reentry
Reentry intervals are required to support the registration of all products for
which the Agency has determined that a reentry hazard exists for persons
reentering treated sites. Ihosalone is an acetyl-cholinesterase inhibiting
pesticide which may present a hazard to persons reentering treated fields.
The parent and phosalone-oxon tend to persist, especially under dry conditions
and present a more hazardous reentry situation.
Popendorf et al., (1979, MRID 005005243) found a correlation between the amount
of dislodgable phosalone residues in peach orchards and the total dermal doses
of workers in the orchard. Ibwever, workers exposed to phosalone residue
levels up to 7 ug/cm on peaches showed no blood cholinesterase depression.
Higher levels would not be expected to occur under actual use conditions.
Several studies presented the results of phosalone residue levels on grapes.
In one study, phosalone was applied at three pounds active ingredient per
acre twice within a five day period to grapes in California. Levels of
dislodgeable foliar phosalone at harvest 87 to 98 days after the last
application were approximately 0.075 to 0.45 ug/cm (Knaak et al., 1978 MRID
005003635). Dislodgeable foliar phosalone and phosalone-oxon levels in another
study were estimated at <0.1-4.8 and <0.1 to 0.83 ppm after 111-115 days,
respectively (Winterlin et al., 1978, MRID 005001343). 3h a separate field
sprayed with phosalone at three pounds active ingredient per acre, dislodgeable
foliar phosalone levels were estimated at 0.7 ug/cm 68 days after
application (Khaak et al., 1978, MRID 005003635).
TWo other studies in California showed that hot weather enhances phosalone's
dissipation on the surface of grape foliage treated with phosalone 3 EC at .2.1-
3 pounds active ingredient per acre. In one study (Leffingwell et al., 1975,
50
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MRID 005007745), dislodgeable phosalone, initially at approximately 175 ppm
(approximately 4 ug/on ), had a half-life about seven days in hot humid
weather (up to 114 ), and a half-life of approximately 14 days in cooler
weather (95 to 105 . . . , ,_ ..... , n . n
maximum). In the other study (Leffingwell et al.,
MRID 005007744), about 25 to 65 percent of the dislodgeable phosalone
dissipated within seven to nine days when maximum air temperatures were
generally >40 C (104 ). Vhen maximum air temperatues dropped to 38 C
(100 F), the dissipation rate slowed and phosalone1s half-life was >30 days.
The temperature effect is probably due to enhanced volatilization and chemical
reaction.
In both studies |he oxygen analogue accumulated to 2.5 to 6.5 ppm
(70 to 180 ng/cm ) during the first eight days after phosalone application.
The accumulation rate slowed thereafter and the level was relatively constant
at 6 to 10 ppn (100 to 250 ng/cm ) 20 to 35 days after application. Neither
the decline pattern of phosalone nor the accumulation of phosalone-oxon was
affected by variable spray concentrations that ranged from 2.25 pounds active
ingredient per acre in 50 gallons of water to three pounds active ingredient
per acre in two gallons. However, the initial concentration of dislodgeable
phosalone was higher with higher spray concentrations, o^017 example,
dislodgeable phosalone levels were about 10 to 16 ug/on one to two days
after application at three pounds active ingredient per acre in twelve gallons,
whereas levels were about 3 to 5 ug/on one day after application at three
pounds active ingredient per acre in 50 gallons (Leffingwell et al., 1975,
MRID 005007745) or 2.25 pounds active ingredient in 23 to 30 gallons of water
per acre (Leffingwell et al., 1974, MRID 005007744).
All these studies show that phosalone and phosalone-oxon residues are present
on crop surfaces several weeks after treatment with phosalone. Thus a safe
reentry interval must be established to protect persons reentering treated
fields from toxic effects of this cholinesterase inhibitor. For each crop, the
registrant is required to propose an acceptable reentry interval. This
proposed interval may be based on the following:
a. Data on dissipation of foliar residues (decline curve), on human
exposure to those residues; and on the inherent toxicity of phosalone;
b. A determination of the time after which no detectable foliar residues
occur under appropriate climatic conditions, in the geographical
area in which phosalone will be applied.
Phosalone is an organophosporothioate (OP) pesticide. These OP pesticides
are among the most toxic pesticides used in American agriculture. They
have caused the majority of the reported incidents of field worker
poisoning episodes, and most of these have been in California. Riosalone has
been implicated as a causative factor in a number of the incidents. In
response to these poisoning incidents, reentry intervals for phosalone have
been proposed twice by the Occupational Safety and Health Administration of the
51
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Department of labor and twice by the Environmental Protection Agency (EPA)
[38 (83) Federal Register 10715; 38 (125) Federal Register 17211; 39 (48)
Federal Register 9457; 39 (92) Federal Register 16888, respectively.] The last
proposed reentry interval of 24 hours was established for phosalone in 40 CFR
170. The State of California has established a seven day reentry interval in
response to the unusual environmental conditions within that State with the
provision that the reentry interval would be waived, if two inches of rain
occurred or if the equivalent of two inches of rain were applied to the crop as
an overhead spray. Khaaket al. (1980, MRID GSOQ.27027) has proposed that the
Reentry level for phosalone should be 7.0 ug/on .
Guidelines for the establishment of Reentry Intervals will soon be proposed by
the EPA. V&thin those Guidelines it will be proposed that reentry intervals
and reentry (residue) levels will be required for the registration of any
pesticide that meets certain criteria. Che of the criteria is that the
pesticide has been implicated in poisoning incident(s). Phosalone meets that
criteria. The Agency is currently reviewing the established 24 hour reentry
interval for phosalone in the light of current scientific information and the
methodology presented in the proposed Guidelines.
Until the Guidelines and the reentry interval review is complete, the Agency
intends to maintain the 24 hour reentry interval as an interim measure. If
the registrant wishes to appeal, interval data may be submitted to the
Agency to support a change.
11. Summary
Although insufficient data are available to form a complete profile of
phosalone1s environmental fate, the available information suggests that
phosalone will hydrolyze at moderately alkaline pH's and will rapidly
photodegrade in water. In soil the degradation of phosalone occurs mainly
by microbial action, though some degradation results from photolysis. The half-
life of phosalone in soil will generally range from less than one day to seven
days. The major products of hydrolysis, photolysis, and soil metabolism are
phosalone-oxon, dechlorinated phosalone, 6-chlorobenzoxazolone, and 3-amino-7-
chloro-2 phenoxazone, all of which are also rapidly degraded in soil. At least
20 unidentified degradation products are formed in minute amounts. The
microbial degradation of glucose, amino acids, and urea in soil is only
temporarily inhibited by phosalone treatment at concentrations higher than the
recommended field dosage rate. The compound does not adversely affect soil
dehydrogenase activity. Phosalone and its metabolites will not leach through
most types of soils. The potential for accunulation of phosalone and its
metabolites in fish is low. However, the identity of the residues taken up by
fish is unknown. Although phosalone rapidly dissipates in soil, unidentified
residues may accumulate in radishes, beans, potatoes, and wheat planted as
rotational crops in treated fields. Although with adequate precautions
phosalone can be safely used, proper reentry intervals are necessary to avoid
potential hazards.
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C. EXPOSURE PROFILE
1. Ml formulations
The use of airblast machines and aircraft increases the potential for exposure
via spray drift to humans, livestock or wildlife outside the application
site. The potential for human exposure via groundwater contamination is low,
as studies with several aged and unaged soils (loamy sand, sandy loam, clay
loam and silt loam) show that phosalone does not leach. The bioacc until at ion
potential is also low, with maximum bioaccemulation factors in catfish,
crayfish, bluegill, and rainbow trout reported at 31, 21, 16, and 16,
respectively.
The mixers and applicators of phosalone formulations have the highest potential
for direct exposure, but no quantitative data are available to estimate the
degree of such exposure. Dermal and eye exposure from splashing during
diluting and mixing operations can result from the use of the emulsifiable
concentrate. Respiratory exposure from "puff back" can occur during opening
and pouring of the wettable powder formulation.The precautionary statements
on the label regarding the use of protective clothing, gloves, and respirators
are adequate to ensure the safety of the mixers and applicators.
2. Vfettable Powder Formulation
One study was conducted to measure worker exposure to phosalone
formulated as a wettable powder following entry into treated fields
(Popendorf et al., 1979, MRID 005005243). There was a very good correlation
between estimated dermal dose and exposure to specific dislodgeable foliar
residues. DLslodgeable foliar phosalone residues, at harvest, ranged from
1,800 ng/cm (22 to 24 days post application) to 7,180 ng/cm (seven to
nine days post application). Dislodgeable phosalone-oxon residue levels were
one to three percent of the total phosalone applied and ranged from 24 to 190
ng/cm , at harvest. Vbrkers harvesting peaches 3 to 24 days after phosalone
applications, at four to five pounds active ingredient per acre received
estimated average dermal doses of phosalone and its oxygen analogue of 9.8 (7.2
to 13.9) and 0.16 (0.15 to 0.20) mg/hour, respectively. Approximately 98 to 99
percent of the total dose was attributed to dermal rather than respiratory
exposure. The estimated respiratory dose of phosalone was approximately 72
ug/hour. The average individual shift in red blood cell cholinesterase
depression was eight to nine percent, well within the normal range of daily
fluctuations. Vforker red blood cell cholinesterase activity was slightly
inhibited (a mean of approximately four percent), when compared to an unexposed
control population. This is not a toxicologically significant decrease. Also,
there were no overt signs of cholinergic effects.
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3. Unspecified formulation
Orange trees in two adjacent fields in California were sprayed with an
unspecified formulation of phosalone at six pounds active ingredient per acre
in 600 gallons of water (Knaak et al., 1978, MRID 005008190). Half-lives of 13
and 21 dayswere obtained for dislodgeable foliar phosalone at initial levels
of 6.4 and 7 ug/on , respectively, ftbrkers pruning trees 14 to 21 days after
application were exposed for three days to dislodgeable phosalone and oxygen
analogue at 2.6 to 3.6 and 0.2 to 0.5 ug/on , respectively.
Ifed blood cell cholinesterase activity in exposed workers was not significantly
different from unexposed controls. Plasma cholinesterase activity of the
workers was significantly lower in both the 14 and 21 day studies. Neither
phosalone nor its metabolites were detected in the urine of exposed workers
(limits of detectability for phosalone, phosalone oxon and 2-amino-5-
chlorophenol were 0.10, 0.10 and 0.16 ppm, respectively).
D. Data Gaps
Several studies are still needed to fulfill the data requirements for the
environmental fate of phosalone. These data requirements include hydrolysis,
anaerobic soil metabolism, adsorption/desorption, terrestrial field
dissipation for field and vegetable crop uses and tree fruit and nut crop uses,
accunulation in rotational crops, and fish accunulation.
For labeling requirements regarding crop rotation and reentry intervals, please
refer to Chapter II.
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CHAPTER VI: TOXICOLOGY
A. Toxicology Profile - Manufacturing-Use Phosalone
B. Toxicology Profile - End-Use Products
C. Toxicology Profile - Oxygen Malogue
D. ffezard Assessment - Manufacturing-Use and End-Use Products
E. Data Gaps - End-Use Products
A. Toxicology Profile - Manufacturing-Use Phosalone
The studies which fulfill or partially fulfill the data requirements for
manufacturing-use phosalone are grouped by topics corresponding to the
appropriate section, which describes those requirements in the Guidelines.
1. Acute Oral Tbxicity
Sufficient data are available to show that phosalone has high acute oral
toxicity, which places phosalone in Tbxicity Category II (See Table 1). Signs
of toxicity included salivation, lacrimation, muscle fasciculations,
convulsions, and respiratory disfunction which preceded death. Most deaths
occurred within 24 hours of dosing.
Therefore, additional data are not required.
2. Acute Dermal Toxicity
There are sufficient data to demonstrate that the manufacturing-use formulation
has a high degree of acute dermal toxicity, which places phosalone in Tbxicity
Category II. The dermal LDcr, is 1530 ing/kg in rabbits with a minimum lethal
dose of 320 mg/kg (Pasquet et al., 1976, MRID 005007746). Deaths occurred
within four days of administration. In a second study acute dermal LD™
values for rabbits and female rats were greater than 1000 mg/kg and 39o mg/kg,
respectively (Dubost et al., 1963, MRID 000006643). Signs of toxicity were
characteristic of cholinesterase inhibition as described for acute oral
toxicity. Deaths occurred within four days.
ISb further testing is needed.
3. Primary Eye Irritation
There is one supplementary eye irritation study (Dubost et al., 1963,
MRID 000006643). It did not follow standard procedures and does not
fulfill this data requirment.
Therefore, data are still required.
There are data available for the EC formulation, which demonstrate
that phosalone is severely irritating to the eye (HDrn et al., 1965,
MRID 000006690). The registrant may use this study to fulfill the primary eye
55
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irritation data requiranent for the technical. Bbwever, this would place the
technical grade material in Tbxicity Category I. In this event the Agency
would require changes in the label, including a statement specifying the use of
protective goggles.
4. Subchronic Oral Tbxicity
Dog studies (Noel et al., 1970, MRID 000006111; Eonoso et al.,1967, MRID
000006203; Fburnel et al., 1966, MRID 000006684; and Jones et al., 1967, MRID
000006205) indicate that a no-observed-effect-level with respect to plasma
cholinesterase inhibition is 25 ppn phosalone in the diet. ND systemic effects
beside plasma cholinesterase inhibition vere observed in dogs given dietary
levels as high as 37.5 ppn for four weeks (Noel et al., 1970, MRID 000006111) .
No other subchronic study clearly characterized a no-observed-effect-level for
systemic effects, because lover doses were used (Eburnel et al.,196 8, MRID
000006684), or because higher doses (100, 200 and 1000 ppm) were administered
for a much longer time (two years) without effects (Donoso et al., 1967, MRID
000006203).
A test in a second species (preferably the rat) is also required by the
guidelines. Although a rat study (Dubost et al., 1963, MRID 000006643) was
conducted, it was limited to male rats and was only five weeks in duration.
Also, it did not establish a no-observed-effect-level with respect to blood
cholinesterase inhibition in male rats.
However, the rat chronic feeding study (tobodard et al., 1967, MRID 000006202)
established a no-observed-effect-level. (See Chronic Feeding Tbxicity.)
Therefore, there is no need for an additional rat study.
ISb further testing is required.
5. Subchronic Neurotoxicity
A subchronic neurotoxicity study (Vfoodard et al., 1966, MRID 000006695) shoved
that phosalone caused no demyelination at dietary levels up to 500 ppn in
chickens treated for 45 days.
ISb further testing is required.
6. Chronic Feeding Tbxicity
Sufficient data on chronic toxicity are available to indicate that phosalone
causes no systemic toxicity in rats fed diets containing 0, 25, 50, or 250 ppm
for two years (ftbodard et al., 1967, MRID 000006202). A no-observed-effect-
level was established at 25 ppn phosalone in the diet for rats with respect to
red blood cell cholinesterase inhibition.
Nb further testing is required.
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7. Qicogenicity
There are sufficient data to show that phosalone does not have oncogenic
effects in rats (see previous section) at dietary levels as high as 250 ppm
(Vfoodard et al., 1968, MRID 000006202) and in mice at dietary levels as high as
ISOppn (Fhone-Poulenc, 1980, MRID GS0027021.) These studies are both
lifetime feeding studies.
tt> further data are needed.
8. Teratogenicity
There are data to demonstrate that phosalone is not fetotoxic or teratogenic in
rats (Khera et al., 1979, MRID 005008254) or rabbits (Pasquet, J. and Buisson
M., 1969, MRID 000006110) at daily doses as high as 15 or 18 mg/kg,
respectively.
Tnese two studies satisfy the minimum data requirement for teratology testing.
9. Reproductive Effects
A three generation reproduction study (Jones et al., 1967, MRID 000006204)
partially fulfills the data requirements for reproduction toxicity testing.
In this study groups of rats were given diets containing 0, 25, or 50 ppm
phosalone. The study was compromised during the second and third generations
by the occurrence of a laboratory infection in test animals. In view of the
rapid metabolism and excretion (Collins, R.E. and Ings, R.M.J., 1967,
MRID 000006977, and Desmoras et al., 1968, MRID 000006715), the lack of
teratogenicity or fetotoxicity at high doses, which are approximately 37 to 56
percent of the acute oral LA-0 in rats (Khera et al., 1979 MRID 05008254 and
Pasquet, J. and Buisson, M., 1969, MRID 000006110), and the absence of
mutagenic activity in bacteria (Benazet, F. and Cartier, J.R., 1978,
MRID GS0027020), the available studies are sufficient to fulfill testing
requirements for reproduction toxicity. The no-observed-effect-level for
these effects is 50 ppm in the diet (the highest level tested).
10. Mutagenicity
A bacterial assay (Benazet, F. and Cartier, J.R., 1978, MRID GS0027020) and a
dominant lethal test in mice (Goldenthal et al., 1978, MRID GS0027019)
indicate that phosalone is not mutagenic. Although these studies only
partially fulfill the data requirements, the results of the studies on
teratogenicity (Khera et al., 1979, MRID 005008254 and Pasquet, J. and Buisson,
M., 1969, MRID 000006110), reproduction (Jones et al., 1967, MRID 000006204),
and oncogencity (Vfcodard et al., 1967, MRID 000006202; and Rhone-Poulenc, 1980,
MRID GS0027021) indicate that further testing is not necessary. 3h addition,
the rapid metabolism and excretion of phosalone and its metabolites (Collins,
57
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R.E. and Ings, R.M.J. , 1967, MRID 000006977 and Dssnoras et al., 1968,
MRID 000006715) further support the decision to waive further testing
requirements.
11. Metabolism and Pharmacodynamics
The available data show that phosalone is metabolized rapidly in the rat
(Collins, R.E. and Ings, R.M.J. , 1967, MRID 000006977 and Degnoras et al.,
1968, MRID 000006715). Fifty percent of the administered dose is metabolized
and excreted within 24 hours after treatment. Metabolites included the oxygen
analogue, diethyldithio- and diethylthionophosphoric acids. The heterocyclic
ring is also rapidly degraded to carbon dioxide, accounting for approximately
two- thirds of administered radiolabel (in the heterocyclic ring) in the rat
(Collins, R.E. and Ings, R.M.J., 1967, MRID 000006977). Most of the remaining
activity is excreted in the urine. Jn vitro studies with liver tissues also
show that phosalone is metabolized to its oxygen analogue (Deanoras et al.,
1968, MRID 000006715).
Studies with mice demonstrate that 98 percent of the administered dose of
phosalone is excreted within 16 hours (Degnoras et al., 1968, MRID 000006715).
Studies with cows given phosalone labeled in the benzene ring showed that the
major route of excretion of administered radioactivity is in the urine.
Approximately 50 percent was excreted during the first 24 hours following
dosing (Qraine, E.M. , 1974, MRID 000006972 and 000006973). A dermal
application of 13.9 milligrams of radiolabeled phosalone was applied to a pig
and showed that the chemical is not aosorbed through the skin (Craine, E.M. ,
1974, MRID 000006975).
Studies concerning cholinesterase inhibition are also available. In one study
groups of 18 female rats were given a single oral dose of 0, 4, 12, or 36
milligram of phosalone per kilogram body weight (Pasquet et al., 1976,
MRID 005007746). Qiol inesterase levels were measured at 2, 5, or 24 hours
after treatment in six animals from each group. The dose required for
50 percent inhibition (ID™) of the cholinesterase activities are summarized
as follows:
ID5f)
Type at 2_ hours _at 5_ hours
Plasma 16.0 16.5
Red blood cell 15.0 10.5
Brain 31 23
In another study by Eournel et al. (1968, MRID 000006716), groups of 18 rats of
each sex were given single oral doses of 0, 3, 9, or 27 milligram phosalone per
kilogram body weight or 1,3, or 9 milligram oxygen analogue per kilogram body
58
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weight. Cne group of six animals of each sex was sacrificed 1.5, 6, or 24
hours after dosing and cholinesterase activities were measured in the blood
(plasma and erythrocytes) and the brain. The investigators stated that peak
inhibition was seen between 1.5 and six hours after treatment. The oxygen
analogue was shown to be a more potent inhibitor of cholinesterase than the
parent compound.
No further testing is necessary for metabolism and pharmacodynamics.
12. A3ditional Information
There are sufficient data to show that phosalone inhibits blood cells
cholinesterase in calves given diets containing 0, 20, 50, 80 or 160 ppm
phosalone for eight weeks (Vfoodard et al., 1967, MRID 000006677). The no-
observed-effect-level for this inhibition was 80 ppn. ISb other toxic effects
were observed. Gbws receiving diets containing 0, 25, 50 or 100 ppm phosalone
for 21 days showed no compound related effects (Tbtmann et al., 1967,
MRID 000006073).
Phosalone in the diets of chickens at 31 or 115 ppm for four weeks decreased
egg production to 69.7 percent and 68.9 percent respectively, as compared
to 74.4 percent for-untreated birds. Egg production in treated birds increased
when they were given diets without phosalone. ISb other effects were noted
(McGinnis, C.H. , Jr., 1974, MRID 000006976). The no-observed-effect-level was
9 ppm with respect to egg production. ISb effect on embryonated chicken
eggs were noted at doses as high as 1.8 milligrams phosalone per egg
(highest dose tested) (Pasquet, J. and Buisson, M., 1969, MRID 000006110).
A study was conducted to determine the effectiveness of antidotes
against a lethal dose of phosalone in mice and rats (Rivett, K.F. and Davies,
V., 1966, MRID 000006697). Che of the antidotes tested was P2S, which is the
chemical nane for l-methyl-pyridyl-2-aldoxine methyl sulphate. It is an
analogue of 2-PAM, which is suggested as an antidote for phosalone poisoning on
the label. The other antidote tested was atropine. Both chemicals are
classified as cholinesterase reactivators and as such are useful in reversing
the effects of cholinesterase inhibition caused by phosalone. In this study
atropine was administered immediately after dosing, while P2S was
administered when signs of toxicity appeared. P-S alone was found to be a
more effective antidote than atropine alone.
B. Toxicology Profile-End-Use Phosalone
The studies which fulfill or partially fulfill the data requirements for the
end-use products are grouped by Guideline requirements and are discussed below.
The requirements for acute dermal toxicity and acute inhalation toxicity have
been fulfilled for the EC formulation. These data will also fulfill these
data requirements for the WP formulation.
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1. /cute Oral Tbxicity
Table 2 summarizes the acute oral LD^Q values for the two formulations, EC
and WP. Signs appeared two hours after dosing. Deaths occurred within 24
hours after treatment. Rats given 147 mg/kg or greater had tremors and
depression, while doses of 215 mg/kg or greater caused salivation and
lacrimation (Scott, W.J. and Beliles, R.P., 1965, MRID 000006688). These
results indicate that the formulations of phosalone have high acute
oral toxicity, placing it in Toxicity Category II.
No additional testing is required for either formulation.
2. Pcute Dermal Ibxicity
There are sufficient data to indicate that the acute dermal toxicity of the
formulations is moderate (Toxicity Category HI). The acute dermal IA-Q
is greater than 2000 mg/kg in male and female rabbits (Horn et al., 1965,
MRID 000006689). ND overt signs of systemic toxicity or cholinesterase
inhibition were seen in rabbits, and only mild erythema was seen in rabbits
treated with the 2000 mg/kg dose.
3. Pcute Inhalation Tbxicity
There are sufficient data to indicate that the acute inhalation toxicity of
phosalone formulations is relatively low (Toxicity Category IV) (Beliles, R.P. ,
1966, MRID 000006981). Tne acute lethal concentration time (LCT5Q) vas found
to be 64 mg hr/liter of air for rats.
4. Hrimary Eye Irritation
There are data indicating that the emulsifiable concentrate is severely
irritating to the eyes of rabbits (tforn et al., 1965, MRID 000006690). Gbrneal
opacity persisted in some of the rabbits for seven days. It should be noted
that the treated eyes were not vashed after instillation of the formulation.
Tne Ajency will accept this study to fulfill this data requirement, even though
it was not conducted for 21 days, as specified in the guidelines. This places
the formulation in Toxicity Category I. Changes in the current label should be
made, as discussed in Chapter II and the guidance package. However, the
registrant may wish to submit additional studies, which are conducted over the
21 day time period. Such studies may result in a lower Toxicity Category.
There are no data available for the WP formulation. Therefore, data are still
required.
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ffowever, the registrant may submit the data fron the EC formulation. Again,
thip would place the WP in Ibxicity Category I. The appropriate changes in the
label vould also be needed, including a statement concerning the use of
goggles.
5. Additional Information
There is one stu3y of antidotes in rats and mice which used lethal doses of the
EC formulation administered orally (Rivett, K.F. and Davies, V., 1966,
MRID 000006697). The results are similar to those described above for the
manufacturing use formulation.
C. Toxicology Profile-Oxygen Analogue
1. Acute Cral Tbxicity
The oral LDcQ of the oxygen analogue in female rats was 21 mg/kg with 95
percent confidence limits of 12 to 28 mg/kg (Pasquet et al., 1976,
MRID 005007746). In male rats the oral LD5Q was found to be 36 mg/kg with a
confidence interval from 29 to 44 mg/kg, wnile that for female rats was 20
mg/kg with a confidence interval from 15 to 29 mg/kg (Fournel et al., 1968,
MRID 000006716). Signs of toxicity were similar to those in animals treated
with phosalone and deaths were seen within 24 hours of treatment with the
analogue.
Additional information is available concerning the oral lA-o in mice.
Fburnel et al. (1968, MRID 000006716) reported 35 mg/kg with a 30 to 41 mg/kg
confidence interval in males and 40 mg/kg with a 33 to 49 mg/kg confidence
interval for females. Societe des Usines Chimique Rione-Poulenc (1968,
MRID 000006674) reported 32 mg/kg. In both cases the signs of toxicity were
indicative of cholinesterase inhibition.
2. Acute Eermal Toxicity
A dermal LDj-nin rats of 380 mg/kg was reported by Pasquet et al. (1976,
MRID 005007/46) with no further information. These data suggest that the
analogue is approximately five times more toxic than the technical or the EC
formulation.
D. Hazard Assessment for Manufacturing and End-Use Products
The phosalone exposure profile (refer to Chapter V) provides that maximum
exposure will occur with those involved in direct mixing, loading, and
application. The principal routes of exposure may be anticipated to be dermal
and inhalational; the latter coming from applicator exposure to spray mist. As
noted above, the acute toxicity of phosalone falls within Categories I through
IV, depending upon route of exposure and formulation. The WP and EC acute oral
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toxicity is relatively high, while acute dermal and inhalation toxicities are
moderate to low. In addition, the acute oral and dermal toxicities of
phosalone-oxon is high. The primary toxic effect of phosalone is its
cholinesterase inhibition. Ihosalone, as demonstrated in a study with the EC
formulation, is also a severe eye irritant causing persistent corneal opacity,
if the chemical is not washed from the eye. The Agency believes that the acute
hazards resulting from exposure to phosalone are mitigated by those
precautionary measures prescribed by the product labeling requirements as
outlined in Chapter II.
Although the Agency does not possess the full complement of chronic toxicity
data as required by the Guidelines, those data available for Agency review do
not indicate any potential for oncogenic, mutagenic, teratogenic, or
reproductive effects. The Agency, therefore, believes that phosalone, when
used according to label directions, presents no chronic hazard.
E. Data Gaps
Data gaps for acute inhalation toxicity, primary dermal irritation, primary eye
irritation, dermal sensitization, and acute delayed neurotoxicity should
be filled for manufacturing-use phosalone. Data for primary dermal irritation
and dermal sensitization are still needed for the EC and WP formulations. Eata
concerning primary eye irritation are still needed for the WP formulation.
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CHAPTER VII. RESIDUE CHEMISTRY
A. Residue Gi em is try Profile
B. Data Caps
A. Residue Chemistry Profile
1. Metabolism in Plants
The metabolism and degradation of phosalone follows a pattern typical of that
of phosphorodithioate esters; i.e. oxidation to the phosphate (oxygen
analogue), hydrolysis and conjugation of the benzoxazolone nucleous with a
gylcoside and further elimination of this conjugate (FAO Working Party of
Experts on Pesticide Residues, 1973, MRID 005013895). Phosalone has been found
to directly hydrolyze although oxidation to the oxygen analogue and then
hydrolysis of this metabolite is the more predominant path of degradation
(Societe des Usines Cnimiques Fhone-Poulenc, 1968, MRID 000006675).
Experiments with de-ethylation reactions have shown that it is very unlikely
that de-ethylation of phosalone in plants will occur (Danoras et al., 1968,
MRID 00006791).
The oxygen analogue of phosalone was detected in treated plants but always at
minute quantities usually about one percent of the total residue and never
more than ten percent (Desmoras et al., 1968, MRID 000006791). After
hydrolysis of phosalone or its oxygen analogue, the diethyldithio- or
thionophosphoric acid leads to the formation of orthophosphoric acid (Desmoras
et al., 1966, MRID 000006386 and Winterlin et al., 1974, MRID 005009309). Tne
benzoxazDlone nucleus of the molecule or 6-chlorobenzoxazDlone has never been
detected by itself. However it was found as a conjugate of a glycoside; i.e.
[ (6-chloro-2-ben2DxazDlone)3-yl]-l-glicopyranose (Desmoras et al., 1968,
MRID 000006791).
Phosalone is not regarded as "systemic"; however, when applied to the soil it
will be absorbed and translocated by seme plants (Kbvaleva, E.S. and Talanov,
G.A., 1977, MRID 005014688). It has been noted that grapes treated with
phosalone showed absorption of phosalone into the pulp instead of being
retained on the skin (Nalbandyan, R.A., 1975, MRID 005016356).
14
A study with potato plants, where the leaves had been treated with C-
phosalone, showed that 99.5 percent of the radioactivity remained at the
treatment area. The formed tubers contained less than 0.01 percent of
radioactivity 14 days after the treatment. This indicates that there is no
translocation of phosalone out of the treated area (Mbrosi et al., 1974,
MRID 000006125).
Accordingly it is understood that the nature of the residue resulting in
plants from a treatment of phosalone is as follows: phosalone per se, its
oxygen analogue (usually one to ten percent of the total residue) and its
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hydrolysis products and [ (6-chloro-2-benzoxazDlone)-3-yl]-l-glucopyranose
present only in trace amounts. The metabolism and degradation
pathways of phosalone in plants are veil defined and no further studies are
necessary.
2. fetabolism in Aiimals
In a study with animals (Desmoras et al., 1968, MRID 000006715)), rats and mice
were fed one dose of phosalone at 35 mg/kg and 50 mg/kg, respectively. The
animals were sacrificed at varying time intervals after ingestion. Samples of
urine, feces and of the whole body were taken for analysis. O/er 99 percent of
the ingested phosalone "disappeared" within 24 hours. Aialysis also showed the
absence of any oxygen analogue of phosalone and 6-chlorobenzoxazolone
residues. Thus, neither phosalone, its oxygen analogue, nor
6-chlorobenzoxa2olone were found in the tissues or excreta.
Important quantities of diethyl dithio- and thiono-phosphoric acids were
detected in the animal body, urine and feces indicating there was hydrolysis
of the phosalone molecule. The 6-chlorobenzoxazolone residue was not
detected.
A metabolism study with dairy cattle (Craine, E.M., 1975, MRID 000006974) was
as performed to identify residues in .milk and urine following the
administration of a single dose of C- benzene ring labeled phosalone. Nb
tissues were analyzed. The major route of elimination of phosalone residues
was reportedly via the urine (86-94 percent); the feces accounted for about
six percent of the remainder. Oily 0.3 percent of C - activity appeared in
the milk (i.e. 0.19 ppn.) Almost all (93-100 percent) of the administered
C - dose was recovered within 104 hours.
14
In the urine about two percent of the C in the dose was excreted as
phosalone per se or its oxygen analogue. Two major urinary metabolites were
isolated and determined to be 2-oxo-3-mercaptomethyl-6-chlorobenzoxazole and
2-amino-5-chlorophenol. The 2-oxo-3-mercaptomethyl-6-chlorobenzoxazole is
formed by hydrolytic cleavage of the S-P bond of phosalone and 2-anino-5-
chlorophenol could subsequently be formed by the hydrolytic opening of the
benzoxazole ring. Another 15 compounds containing low levels of radioactivity
were present; however they were not identified.
14
In milk less than 10 percent of the 0.19 ppm C - activ ity present was
identified as phosalone or its oxygen analogue ( <0.02 ppm). The major
metabolites found were 2-amino-5-chlorophenol (0.08 ppm) and 2-oxo-3-
mercaptomethyl-6-chlorobenzoxazole (0.03 ppm). Other compounds containing
radioactivity were also present but at levels too low to warrant
identification (0.03 ppm).
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The presence of these two compounds in milk caused the Agency to request Rione-
Poulenc to submit additional methodology capable of measuring all
chlorobenaoxaaDle-and chlorophenol moiety-containing metabolites. Such
methodology must be able to measure the chlorophenol metabolite(s) as separate
entities. Residue studies submitted in December of 1980 by Rione-Poulenc
concerning meat, milk, poultry and eggs in conjunction with a pending
registration action for the use of phosalone in or on alfalfa showed the
possible presence of residues of secondary phosalone metabolites. These
studies are still awaiting final review.
Metabolism data indicate that phosalone per se is the primary residue of
concern after use of phosalone on raw agricultural crops. The metabolism of
phosalone in animals is considered, however, to be adequately defined at the
present time.
3. Analytical Methodology
a. Agricultural Crops
The following references discuss chronologically the development of the
analytical method which was used for the collection of the majority of the
residue data on the agricultural crops subject to this registration Standard:
Desnoras, J. , 1965, MRID 005016979; Guardigli, A., 1964, MRID 000006383;
Guardigli, A., 1968, MRID 000006703 and GS0027010; Guardigli, A. and Melkesian,
B., 1968, MRID 000006083; Guardigli et al., 1967, MRID 000006678; Guardigli et
al., 1971, MRID 005008180; Laurent et al., 1967, MRID 000006700 and Societe
des Usines Chimiques Fhone-Poulenc, 1968, MRID 000006701. This method, known
as Ihone-Poulenc's Method ISb. 54A, was also adopted as the regulatory
enforcement method and is therefore published in the Pesticide Analytical
Manual, tolune II, Section 120. 263.
Method ISb. 54A is the main method which determines the concentration of the
parent compound present and consists of a gas chromatographic procedure. Thin
layer chromatographic (TLC) methods (Rhone-Poulenc1 s Methods ISb. 54D and 54E)
are employed for the determination of the oxygen analogue of phosalone, the
metabolite [ (6-chloro-2-ben2DxazDlone)-3-yl]-l-glucopyranose and may also be
used to confirm the presence of the parent compound.
In method Isb. 54A the residue is extracted from the crop with acetone and
buffered. The solvent is evaporated. The aqueous phase is extracted with
methylene chloride. The extract is cleaned up by liquid partition on a
Florisil colunn. After elution with ethyl acetate and evaporation, the residue
is dissolved in benzene. The amount of pesticide is determined with the use
of a gas chromatograph utilizing electron capture system. This method is
supplemented by a TLC procedure for confirmatory purposes.
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Recoveries obtained in a method try-out on apples ranged from 74-91 percent
at 10 ppm and 95 percent at 20 ppm. The sensitivity of the method is 0.1 ppm.
Overall, recoveries obtained at fortification levels from 0.25-2.0 ppm
averaged 92.5 percent.
When thin layer chromatographic methods 54D and 54E are employed, the final
cleaned-up extract in benzene is spotted versus standard solutions on a TLC
plate coated with Silico Cfel GF254. The plate is developed in the proper
elution median. After air drying, the plate is sprayed with a 2N sodium
hydroxide solution and heated for five minutes at 120 C. After cooling, the
plate is sprayed with a specific detection reagent. Phosalone as low as
0.1 ppm in the presence of other pesticides can be detected.
b. Meat and Milk
For the analysis of meat and milk samples, a modification of method ND. 54A is
used. The modification consists of a change in the clean-up procedure. This
modified procedure is known as method 54C (Guardigli, A., 1967, MRID 000006129;
1971, MRID 000006762; 1973, MRID 000006105.) Although this method will
determine both phosalone and its oxygen analogue, this method was tried-out in
one of EPA's laboratories for phosalone only in beef fat. Samples fortified at
0.25 ppm and 0.50 ppm of phosalone produced recoveries ranging from 88-92
percent and 92-98 percent, respectively. The controls were <0.005 ppm. The
method as tried out by Ibone-Poulenc1 s laboratory for milk at fortification
levels of 0.1-0.5 ppm of phosalone gave recoveries from 80-99 percent.
Recoveries from tissues at levels from 0.2-0.5 ppm ranged from 83-97 percent.
Control values were not more than 0.05 ppm in animal tissues and <0.0255 ppm in
milk. The sensitivity of the method is estimated to be 0.1-0.2 ppm for meat
and milk.
Accordingly it is concluded that adequate methodology is available for the
collection of residue data and for enforcement purposes for measurement of
combined residues of phosalone and its oxygen analogue in and on raw
agricultural commodities including meat and milk. Methods for phosalone
published in the Pesticide Analytical Manual are adequate for enforcement
purposes. As previously mentioned, however, new methods are currently being
reviewed in a pending registration action concerning the use of phosalone in or
on alfalfa.
4. Residues in Plants and Anmals
The reported residue studies overall reflect the registered uses of phosalone
on raw agricultural crops, processed foods, by-products and feed items.
Feeding studies reflecting residues of phosalone in large animals and poultry
were adequate in exhibiting the possible transfer of residues of phosalone to
meat, milk, poultry and eggs.
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Ihe established tolerances for residues of phosalone which may result from
the registered uses are found adequate for the raw agricultural commodities as
well as the processed foods, by-products and feed items. The established
tolerance (0.25 ppm) for meat, fat and meat by-products of cattle, goats,
hogs, horses and sheep is adequate to cover possible residues of phosalone
which may transfer to these commodities.
Itesidues in milk, poultry and eggs, resulting fron the registered uses of
phosalone are considered representative of category three of section 180.6(a);
i.e., it is not possible to establish with certainty whether finite residues
will be incurred, but there is no reasonable expectation of finite residues.
It is possible that the 0.25 ppn tolerance for residues of phosalone in the
meat, fat, and meat by-products of cattle, goats, hogs, horses and sheep, may
have to be raised in value and incluSe particular metabolites present in
tissues and milk, pending a registration action for phosalone use in or on
alfalfa. (Please refer to chart in Chapter III for a listing of the citations,
which are grouped by the crop studied.)
5. Storage Stability
Several studies containing information on the storage stability of samples of
technical and formulated phosalone show that phosalone is very stable (Eeanoras
et al., 19??, MRID 000006968; Klisenki, M.A. and Pis'mennaya, M.V. , 1973,
MRID 005014548; Laurent et al., 1965, MRID 000006698 and Fhodia, Inc., 19??,
MRID 000006113). (See Chapter IV, Product Chemistry, Physical/Chemical
Properties for a detailed discussion.)
6. Tolerance Levels
a. Present U.S. Tolerances
1). Raw Agricultural Gbmmodities
According to 40 CFR 180.263 tolerances for residues of phosalone, in or on raw
agricultural commodities are as follows:
50 ppn in or on almond hulls.
25 ppn in or on artichokes.
15 ppm in or on apricots, cherries, nectarines,
peaches, and pluns (fresh prunes).
10 ppm in or on apples, grapes, and pears.
3 ppn in or on citrus fruit.
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0.25 ppn in the meat, fat, and meat by-products of
cattle, goats, hogs, horses, and sheep.
0. Jppn (negligible residue) in or on almonds
and potatoes.
0.05 ppn (negligible residue) in or on brazil
nuts, bush nuts, butternuts, cashews, chestnuts, filberts,
hazelnuts, hickory nuts, macadamia nuts, pecans and walnuts.
2). Processed Foods
Also according to 21 CFR 561.300, tolerances for residues of phosalone are
established in or on the following processed foods, when present therein as a
result of the application to growing crops:
8 5 ppn in or on dried apple pomace.
45 ppm in or on dried grape pomace.
12 ppm in or on dried citrus pulp.
In addition, according to 21 CFR 193.340 tolerances are established for
residues of the insecticide phosalone in or on the following processed foods
when present therein as a result of application to the growing crops;
4 0 ppn in or on dried prunes.
20 ppm in or on dried raisins.
8 ppn in or on dried tea.
b. CODEX Tolerances
A list of suggested maxdmun limits in ppm for residues of phosalone on an
international basis is exhibited below.
These limits were a result of joint meetings on lesticides Ifesidues in 1972,
1975, and 1976. The Acceptable Daily Intake (ADI) was calculated to be 0.006
mg/kg body weight.
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CODEX Tolerances
Maximum (ppn) for
Conmodity Phosalone Residues
/pples 5
Beet roots 2
Broccoli 1
Brussels grouts 1
Cabbage 1
CherrieslO
Chestnuts 0.1(*)
(Shell-free Basis)
Citrus Fruit 1
Cucumber 1
Grapes 5
fops (Dried) 2
Lettuce 1
Iteaches 5
Pears 2
Ifeas 1
Pecans 0.1(*)
(9iell-free Basis)
Plums 5
Potatoes O.K*)
Rapeseed 0.1(*)
Sleep, Eat 0.5
Sheep, Carcass Meat 0.05(*)
Stravfcerries 1
Tomato 1
(*)Level at or about the limit of determination
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A comparison of the U.S. tolerances with the CODEX tolerances indicates that
most of the U.S. tolerances are remarkably higher than the CCDEX tolerances. A
reassessment of the U.S. tolerances indicates that it is impractical to lover
the U.S. tolerances due to the level of residues that result from the
registered use in the U.S.
Some CODEX tolerances are higher, however. For example, the CODEX tolerance
for residues of phosalone in the fat of sheep (0.5 ppm) is twice that of the
U.S. (0.25). This is because the CCDEX tolerance reflects residues resulting
from a "sheep-dip" use, a use which is not registered in the U.S.
The U.S. tolerance for animal fat reflects phosalone residues resulting from
feeding the animals crops treated with phosalone; this use is not considered
under the international tolerance. The U.S. tolerance for phosalone in meat,
fat, and meat by-products of cattle, goats, hogs, horses, and sheep is being
reevaluated due to the pending registration action for use in or on alfalfa.
The CODEX tolerance of 0.1 ppm for pecans and chestnuts (nuts) is also higher
than that of the U.S. tolerance of 0.05 ppm for nuts (except almonds) . Both
tolerances are based on the sensitivity of the method used. The U.S. tolerance
is a negligible tolerance and could be made consistent with the CODEX
tolerance (i.e. 0.1 ppm) for the nut grouping (except almonds) as defined under
Title 40, section 180.34(f), which states in part,
"It may be possible to make a reliable estimate of negligible
residues of pesticide chemicals to be expected on each commodity in a
designated grouping on the basis of data on a representative number of
commodities listed in the following designated groups."
The commodities listed for nuts include Brazil nuts, bush nuts, butternuts,
cashews, chestnuts, filberts, hazelnubs, hickory nuts, macadamia nuts, pecans,
and walnuts.
A change in the tolerance to a higher level, however, is dependent upon a
recalculation of the Theoretical Maximum Residue Concentration (TMRC). The
Agency recalculated the TMRC and found that it would be appropriate to make
the U.S. tolerance for nuts (except almonds) consistent with the CODEX
tolerance of 0.1 ppm. The result is discussed in Chapter 2 under the
Tolerance Reassessment Section.
7. Special local ISeed Registrations
In 1980, additional uses for the application of phosalone by aircraft to
almonds, grapes, stone fruit and walnuts were granted by California under
Section 24 (c) of FIFRA, which provides for a state to obtain additional uses
to meet special local needs. The maximum use per acre for all crops is the
same as for those applied by ground equipment except the spray volume for the
aerial application can be reduced to a minimum of 20 gallons of water. Vfe have
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reviewed the data reflecting the residues resulting fron the ground
applications and in conjunction with the fact that F.D.A. Market Basket
Surveillance data report residues of phosalone considerably below the
established tolerances; it is concluded that the registered Section 24 (c) uses
are in compliance with the respective established crop tolerances.
B. Data Gaps
No generic data gaps were identified with regard to Ffesidue Chemistry.
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CHAPTER VIII: ECOLOGICAL EFFECTS
A. Ecological Effects Profile
B. Hazard Evaluation
C. Data Gaps
A. Ecological Effects Profile
Phosalone, as noted earlier in the Use Summary section of Chapter V, is an
insecticide and miticide applied to agricultural and commercial ornamental
crops. It may be applied by ground or aerial equipment to agricultural sites
and by ground equipment to ornamentals. As a result of these methods of
application, some potential exists for the exposure of nontarget terrestrial
and aquatic organisms.
1. Birds and Aquatic Invertebrates
In relation to the toxicity of phosalone to birds and aquatic invertebrates,
limited data are available. However, these studies are considered inadequate,
because they failed to meet guideline requirements. It is thus not
possible to assess phosalone1 s toxicity to these nontarget organisms.
Therefore, data are still required.
2. Fish
With respect to the toxicity of phosalone to fish, the available data indicate
that it may be highly toxic to both warmwater (McCann, J.A. and
Jasper, R.L. , 1972, MRID 005009810; USDA, 1969, MRID GS0027002) and coldvater
fishes (USDA, 1969, MRID GS0027001). The USDA study (MRID GS0027001) reports
a 96 hour 1C 5Q of 0.92 ppm for coldwater fishes. This study was conducted
with a 34.8 percent active ingredient formulation and characterizes
this formulation as being highly toxic to coldvater fishes. The
studies concerning the warmwater fishes (MRID 005009810 and GS0027002) ware
also conducted with the 34.8 percent active ingredient formulation. These
studies did not report an 1C J-Q value, but did indicate high toxicity.
However, the proposed guidelines require that the studies be conducted with the
technical product, in order to evaluate the effect of the chemical itself on
fishes. Studies performed with technical material facilitate extrapolation for
all formulations. Therefore, data are still required with technical phosalone
on both warmwater and coldwater fishes.
3. Plants
The data base concerning the toxicity of phosalone to nontarget plants and
microorganisms is somewhat limited. Information on the effects of
phosalone applied at the recommended rates on citrus, stone fruits,
nuts, apples, grapes and potatoes is available. These data show no adverse
effects on the plants tested.
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Several vegetables for which phosalone is not registered were tested under
greenhouse conditions and showed injury. Cucunber, however, was the
only plant tested under both greenhouse and field conditions, and displayed no
phytotoxic symptoms when treated at one pound active ingredient per acre for
the field test. This was twice the rate applied in the greenhouse study. The
results from the field study reflect the potential exposure of plants to
phosalone more accurately, and the Agency, consequently, ass ones that the
affected vegetables would be more tolerant in the field.
The label indicated a potential for injury on roses, although no valid studies
were received to confirm this.
Although the studies mentioned above were not conducted under the
specifications of the proposed guidelines (40 FR 72910; November 3, 1980), the
Agency has determined that the studies, in aggregate, provide sufficient
information to fulfill the data requirement for vegetative vigor for
dicotyledonous plants. These studies adequately describe the phytotoxic
effects of phosalone to these plants. (Please refer to the Chapter III charts
for ecological effects for the citations.) To completely fulfill this data
requirement, however, data must still be submitted for representative
monocotyledonous plants. The data requirements for effects on seed
germination, algae, and aquatic macrophytes must also be met, because no
studies were either submitted or located in the literature.
4. Soil and Terrestrial Invertebrates
With respect to phosalone's toxicity to nontarget soil and terrestrial
invertebrates, the available information shows that the adverse effects of
phosalone to phytoseiid predaceous mites are highly variable and species
specific (Croft, B.A. and Stewart, P.G., 1973, MRID 005009346; Croft, B.A. and
Nelson, E.E. , 1972, MRID 005009345; Karg, W., 1978, MRID 005020178; Nelson et
al., 1973, MRID 005005773; Vfetve, C.M. and Lienk, S.E., 1975, MRID 005013359;
Witve, C.M. and Lienk, S. E., 1976, MRID 005014275).
Available information indicates that phosalone is moderate in toxicity to honey
bees, Apis mellifera by either direct spray or residual contact (Atkins, E.L.
and Anderson, L. D., 1967, MRID 000006654; Atkins et al., 1970, MRID 000006653;
Atkins et al., 1973, MRID 000006652; Grahame, R. E., 1967, MRID 000006657;
Smyth, E.P. and Jbhansen, C., 19??, MRID 000006793). Si addition, a residual
contact test for wild bees was conducted with the leafcutter bee, Megachile
pacifica, and the alkali bee, Nomia melanderi (Smyth et al., 19??,
MRID 000006793) and low toxicity was demonstrated. This low to moderate
toxicity to pollinators may be mitigated by restricting application to times
when bees are not actively foraging. See Chapter II for appropriate label
statements.
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ALthough these data concerning nontarget soil and terrestrial invertebrates are
quite limited, they appear adequate for current hazard labeling
needs. Additional studies may, however, be required upon the promulgation of
the Guidelines Subpart L, ffezard Evaluation: ISbntarget Insects.
B. Hazard Assessment
Due to the limited amount of information available, a detailed hazard
assessment for wildlife cannot be made at this time. There is an indication
that phosalone does not present a serious hazard to dicotyledonous plants.
There is also an indication that phosalone may be highly toxic to warmwater and
coldwater fishes and low to moderately toxic to pollinators.
C. Data Gaps
Tests to assess the ecological effects of phosalone are required, with
the exception of the vegetative vigor requirement for dicotyledonous plants.
Please refer to the data charts in Chapter III for the specific requirements.
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IX. CASE BIBLIOGRAPHY
Guide to Use of This Bibliography
1. Content of Bibliography. This bibliography contains citations of all the
studies reviewed by EPA in arriving at the positions and conclusions stated
elsewhere in this standard. Primary sources for studies in this
bibliography have been the body of data submitted to EPA and its
predecessor agencies in support of past regulatory decisions, and the
published technical literature. The bibliography is divided into two
sections: (1) citations that contributed information useful to the
review of the chemical and are considered to be part of the data base
supporting registrations under the standard and (2) citations that have been
examined and judged to be inappropriate for use in developing the standard.
2. Units of Entry. The unit of entry in this bibliography is called a
"study". In the case of published materials, this corresponds closely to
an article. In the case of unpublished materials submitted to the Agency,
the Agency has sought to identify documents at a level parallel to a
published article from within the typically larger volumes in which they
were submitted. The resulting "studies" generally have a distinct title
(or at least a single subject), can stand alone for purposes of review, and
can be described with a conventional bibliographic citation. The Agency
has attempted also to unite basic documents and commentaries upon them,
treating them as a single study.
3. Identification of Entries. The entries in this bibliography are sorted
by author, date of the document, and title. Each entry bears, to the left
of the citation proper, a nine-digit numeric identifier. This number is
unique to the citations and should be used at any time specific reference
is required. This number is called the "Master Record Identifier" or
"MRID". It is not related to the six-digit "Accession Number", which has
been used to identify volumes of submitted data; see paragraph 4(d)(4)
below for a further explanation. In a few cases, entries added to the
bibliography late in the review may be preceded by a nine-character
temporary identifier. This is also to be used whenever a specific
reference is needed.
4. Form of the Entry. In addition to the Master Record Identifier (MRID),
each entry consists of a bibliographic citation containing standard
elements followed, in the case of materials submitted to EPA, by a
description of the earliest known submission. The bibliographic
conventions used reflect the standards of the American National Standards
Institute (ANSI), expanded to provide for certain special needs. Some
explanatory notes of specific elements follow:
75
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a. Author. Whenever the Agency could confidently identify one, the
Agency has chosen to show a personal author. When no individual was
identified, the Agency has shown an identifiable laboratory or testing
facility as author. As a last resort, the Agency has shown the first
known submitter as author.
b. Document Date. When the date appears as four digits with no
question marks, the Agency took it directly from the document. When a
four-digit date is followed by a question mark, the bibliographer
deduced the date from evidence in the document. When the date appears
as (19??), the Agency was unable to determine or estimate the date of
the document.
c. Title. This is the third element in the citation. In some cases it
has been necessary for Agency bibliographers to create or enhance a
document title. Any such editorial insertions are contained between
square brackets.
d. Trailing Parentheses. For studies submitted to us in the past, the
trailing parentheses include (in addition to any self-explanatory
text) the following elements describing the earliest known
submissions:
(1) Submission Date. Immediately following the word 'received1
appears the date of the earliest known submission, at the time
that particular document was processed into the Pesticide
Document Management System.
(2) Administrative Number. The next element, immediately following
the word 'under', is the registration number, experimental permit
number, petition number, or other administrative number
associated with the earliest known submission, at the time that
particular document was processed into the Pesticide Document
Management System.
(3) Submitter. The third element is the submitter, following the
phrase 'submitted by'. When authorship is defaulted to the
submitter, this element is omitted.
(4) Volume Identification. The final element in the trailing
parenthesis identifies the EPA accession number of the volume in
which the original submission of the study appears. The six-
digit accession number follows the symbol 'CDL1, standing for
"Company Data Library". This accession number is in turn
followed by an alphabetic suffix which shows the relative
76
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position of the study within the volume. For example, within
accession number 123456, the first study would be 123456-A; the
second, 123456-B; the 26th, 123456-Z; and the 27th,123456-AA.
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006409 Ambrosi, D.; Buys, M.; Desmoras, J.; Laurent, M.; Sasmayoux, ?;
Savary, ? (1974) Insecticides: Degradation of Phosalone (RP
11974) under Ultra-Violet Light: S.U.C.R.P.—D.S.Ph./
D.S.An. Nord No. 17761. (English translation; unpublished study
received Mar 24, 1975 under 3F1337; prepared by Societe des
Usines Chimiques Rhone-Poulenc, submitted by Rhodia, Inc.,
New Brunswick, N.J.; CDL:093574-Q)
000006664 Ambrosi, D.; Desmoras, J.; Blanchard, ?; Leteve, ?; Savary, ?
(1977) Insecticides: Phosalone: Study on Persistence of Re-
labelled Phosalone in Soil: Rotational Crops: R.P./R.D./
C.N.G. No. 19040. (Unpublished study received May 10, 1977
under 359-620; prepared by Societe des Usines Chimiques Rhone-
Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth Junction,
N.J.; CDL:229759-D)
000006666 Ambrosi, D.; Desmoras, J.; Blanchard, ?; Savary, ? (1977) Phosa-
lone: Photodegradation in Soil: R.P./R.D./C.N.G. No. 19046. In-
cludes undated method. (Unpublished study received May 10, 1977
under 359-620; prepared by Societe des Usines Chimiques Rhone-
Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth Junction,
N.J.; CDL:229759-F)
000006667 Ambrosi, D.; Desmoras, J.; Huguet, ? (1976) Insecticides: Phosa-
lone: Effects on Soil Microorganisms: R.P./R.D./
C.N.G. No. 18787. (Unpublished study received May 10, 1977 un-
der 359-620; prepared by Societe des Usines Chimiques Rhone-
Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth Junction,
N.J.; CDL:229759-H)
000006663 Ambrosi, D.; Desmoras, J.; Huguet, ?; Lingart, ?; Savary, ? (1976)
Herbicides: Phosalone: Studies on Leaching in Different Soils:
R.P./R.D./C.N.G. No. 18752. (Unpublished study received May 10,
1977 under 359-620; prepared by Societe des Usines Chimiques
Rhone-Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, N.J.; CDL:229759-C)
000006125 Ambrosi, D.; Desmoras, J.; Savary, M. (1974) Phosalone: Transloca-
tion Study in Potato Plants Using 14C-Labelled Phosalone:
S.U.C.R.P.—D.S.Ph. No. 17416. (Unpublished study received Feb
12, 1974 under 4E1468; prepared by Societe des Usines Chimiques
Rhone-Poulenc, submitted by Interregional Research Project
No. 4, New Brunswick, N.J.; CDL:093909-C)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
005008305 Ambrosi, D.; Isensee, A.R.; Macchia, J.A. (1978) Distribution of
oxadiazon and phosalone in an aquatic model ecosystem. Journal
of Agricultural and Food Chemistry 26(1):50-53.
005009356 Ambrosi, D.; Kearney, P.C.; Macchia, J.A. (1977) Persistence and
metabolism of phosalone in soil. Journal of Agricultural and
Food Chemistry 25(2):342-347. •
000006652 Atkins, E.L.; Greywood, E.A.; Macdonald, R.L. (1973) Toxicity of
Pesticides and Other Agricultural Chemicals to Honey Bees:
Laboratory Studies. Rev. By Univ. of California, Dept. of
Entomology. Riverside, Calif.: U.C. (Agricultural Extension
M-16; also In unpublished submission received Nov 17, 1975 un-
der 359-620; submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, -N.J.; CDL:223344-A)
000006654 Atkins, E.L., Jr.; Anderson, L.D. (1967) Toxicity of Pesticides and
Other Agricultural Chemicals to Honey Bees: Laboratory Studies.
Rev. By"Univ. of California, Dept of Entomology. Riverside,
Calif.: U.C. (Agricultural Extension M-16; also In unpublished
submission received Nov 17, 1975 under 359-620; suEmitted by
Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:223344-D)
000006653 Atkins, E.L., Jr.; Anderson, L.D.; Nakakihara, H.; Greywood, E.A.
(1970) Toxicity of Pesticides and Other Agricultural Chemicals
to Honey Bees: Laboratory Studies. Rev. By Univ. of Califor-
nia, Dept. of Entomology. Riverside, Calif.: U.C. (Agricul-
tural Extension M-16; also _In unpublished submission received
Nov 17, 1975 under 359-620; submitted by Rhone-Poulenc, Inc.,
Monmouth Junction, N.J.; CDL:223344-B)
000006109 Barrows, M.E. (1975) Kinectics [sic] of 14C-Phosalone in a Model
Aquatic Ecosystem. (Unpublished study received Mar 4, 1976
under 6F1753; prepared by EG&G, Bionomics, submitted by Rhodia,
Inc., Monmouth Junction, N.J.; CDL:095979-H)
000006981 Bellies, R.P. (1966) Phosalone (R.P. 11974): Safety Evaluation by
Acute Inhalation Exposure of Rats. (Unpublished study received
Dec 15, 1966 under 7G0575; prepared by Woodard Research Corp.,
submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
CDL:090729-C)
GS0027020 Benezet, F.; Cartier;, J.R. (1978) Phosalone (11,974 R.P.)-
Mutagenicity Study on Salmonella typhimurium. R.P./R.D./C.N.G.
Report No. 19 234 E. (Unpublished transaltion of study
received Dec 4, 1980 under 6F1753; submitted by Rhone-Poulenc,
Inc., Monmouth Junction, NJ; CDL:099788)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
005005128 Brun, G.L.; Surette, D.; Mallet, V. (1973) A new method for the
detection of organophosphorus pesticides by in situ fluorometry
on thin-layer chromatograms. International Journal of
Environmental Analytical Chemistry 3(1):61-71.
000014256 Ciarletta, J.A.; Smith, R.L.; Sleesman, J. (1975) Moni-
tor (R): Efficacy, Phytotoxicity and Yield Effects on Peppers.
(Unpublished study including report nos. 31525, 31659, 31726,
31735, 32153, 36254, 36258, 36259, 36337, 36342, 36345, 36346,
39118, 39140, 39799, 40064, 40729, 40946, 41098, 42715, 42880,
42916, 43225, 43379 and 44930, received Aug 24, 1978 under 3125-
280; submitted by Mobay Chemical Corp., Agricultural Div.,
Kansas City, Mo.; CDL:097315-A)
000006977 Collins, R.F.; Ings, R.M.J. (1967) Phosalone (11,974 R.P.): Metabo-
lism and Residue Study in Rats (Preliminary Study with 14C-(2)-
Phosalone): BIOCHEM/352. (Unpublished study received Mar 4,
1976 under 6F1753; prepared by May & Baker, Ltd., submitted by
Rhodia, Inc., Monmouth Junction, N.J.; CDL:098088-U)
000006978 Collins, R.F.; Roxburgh, J. (1967) Phosalone (11,974 R.P.): Studies
of Levels in the Skin and Edible Tissues of Sheep: Gas-Liquid-
Chromatography (G.L.C.) Determinations: BIOCHEM/353. (Unpub-
lished study received Mar 4, 1976 under 6F1753; prepared by May
& Baker, Ltd., submitted by Rhodia, Inc., Monmouth Junction,
N.J.; CDL:098088-V)
000006972 Craine, E.M. (1974) Disposition of Phosalone-14C in a Lactating
Cow: Research Report No. EMC 74:17. (Unpublished study received
Mar 4, 1976 under 6F1753; submitted by Rhodia, Inc., Monmouth
Junction, N.J.; CDL:098088-M)
000006973 Craine, E.M. (1974) Disposition of Phosalone-14C in a Lactating
Cow: Research Report No. EMC 74:84. (Unpublished study received
Mar 4, 1976 under 6F1753; submitted by Rhodia, Inc., Monmouth
Junction, N.J.; CDL:098088-N)
000006975 Craine, E.M. (1974) The Disposition of Phosalone-14C Applied to the
Skin of a Pig: Research Report No. EMC 74:30. (Unpublished
study received Mar 4, 1976 under 6F1753; submitted by Rhodia,
Inc., Monmouth Junction, N.J.; CDL:098088-P)
000006974 Craine, E.M. (1975) The Metabolism of Phosalone-14C in Dairy Cows:
Research Report No. EMC 75:51. (Unpublished study received Mar
4, 1976 under 6F1753; submitted by Rhodia, Inc., Monmouth Junc-
tion, N.J.; CDL:098088-0)
005009345 Croft, B.A.; Nelson, E.E. (1972) Toxicity of apple orchard
pesticides to Michigan populations of Amblyseius fallacis.
Environmental Entomology 1(5):576-579.
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
005009346 Croft, B.A.; Stewart, P.G. (1973) Toxicity of one carbamate and
six organophosphorus insecticides to O-P resistant strains
of Typhlodromus occidentalis and Amblyseius fallacis.
Environmental Entomology 2(3):486-488.
000006735 Crouch, R.V. (1970) Phosalone (11974 R.P.): Residue Studies on Tea
(Green Leaf): Pakistan 1969: Report No. RG/758. (Unpublished
study received Jun 8, 1973 under 3H5038; prepared by May &
Baker, Ltd., submitted by Rhodia, Inc., New Brunswick, N.J.;
CDL:221773-H)
000006528 DeLay, D.L. (1968) Report No. PA 68-43. (Unpublished study re-
ceived Feb 16, 1970 under OF0948; submitted by Rhodia, Inc., New
Brunswick, N.J.; CDL:092026-H)
000006569 DeLay, D.L. (1969) Summary Report: District Project No. PA 69-15.
(Unpublished study received Feb 16, 1970 under OF0948; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:092026-BB)
000006534 Delay, D.L. (1969) Summary Report: District Project No. PA 69-29.
(Unpublished study received Feb 16, 1970 under OF0948; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:092026-Q)
000006069 Dennis, S. (1973) Phosalone—Dried Grape Pomace Data. Includes
undated method. (Unpublished study including residue final re-
port no. 170473-092, received Jul 26, 1974 under 5H5058; sub-
mitted by Rhodia, Inc., Somerset, N.J.; CDL:221786-A)
005016979 Desmoras, J. (1965) Dosage biologique de la phosalone ou 11.974
R.P.: application a 1"etude de la degradation de la phosalone
dans les plantes et le sol. [Biological determination of
phosalone or 11,974 R.P.: application to the study of
degradation of phosalone in plants and in the soil.]
Mededelingen van de Landbouwhogeschool en de Opzoekingsstations
van de Staat te Gent. [Communications of the Agricultural
University and the State Research Station of Ghent.]
29(3):1221-1234.
000006770 Desmoras, J.; Ambrosi, D.; Savary, ? (1975) Phosalone: Degradation
in Sterile and Non-Sterile Soil Using 14C-Labelled Phosalone:
R.P./R.D./Biol—No.22. (Unpublished study received Mar 24,
1975 under 3F1337; prepared by Societe des Usines Chimiques
Rhone-Poulenc, submitted by Rhodia, Inc., New Brunswick, N.J.;
CDL:093574-J)
000006209 Desmoras, J.; Buys, M.; Laurent, L. (1973) Phosalone Residues in
Tea: S.U.C.R.P.—D.S.Ph./D.S.An.Nord No. 17389. (Unpublished
study received on unknown date under 3H5038; prepared by Societe
des Usines Chimiques Rhone-Poulenc, submitted by Rhodia, Inc.,
New Brunswick, N.J.; CDL:221773-A)
-------
000006715
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
Desmoras, J.; Fournel, J.; Bredenbach, ?; Savary, ? (1968) Studies
on Degradation of Phosalone in Mammals: R.P.—D.S.Ph. No. 12667.
(Unpublished study received Jun 14, 1968 under 8F0668; prepared
by Societe des Usines Chimiques Rhone-Poulenc, submitted by
Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:091171-AK)
000006707
000006968
Desmoras, J.; Laurent, M.; Aublet, ?; Sasmayoux, ?; Savary, ?
(1968) Phosalone: Determination of Phosalone, 12244 R.P. and
20650 R.P. in Fruit from the U.S.A.: R.P.—D.S.Ph./D.S.An.Nord
No. 12850. (Unpublished study received Jun 14, 1968 under
8F0668; prepared by Societe des Usines Chimiques Rhone-Poulenc,
submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
CDL:091171-1)
Desmoras, J.; Laurent, M.; Buys, M. (19??) Phosalone. Pages 385-
397, T_n Analytical Methods for Pesticides and Plant Growth Regu-
lators—Thin Layer and Liquid Chromatography and Analyses of
Pesticides of International Importance: Volume VII. Edited by
G. Zweig. New York: Academic Press. (Also In unpublished sub-
mission received Mar 4, 1976 under 6F1753; submitted by Rhodia,
Inc., Monmouth Junction, N.J.; CDL:098088-1)
000006791 Desmoras, J.; Laurent, M.; Sauli, M.; Terlain, B. (1968) Metabolism
study of Phosalone in plants and soils. Phytiatrie-Phytopharma-
cie 4:263-275. (Presented at the VI International Congress
for the Protection of Plants, Vienna, 8-30-67 to 9-6-67;
also _In unpublished submission received Jun 13, 1974 under 359-
620; submitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.;
CDL:120351-C)
000006386 Desmoras, J.; Laurent, M.; Terlain, B.; Aublet, J.C.; Sasmayoux,
J.C.; Savary, M. (1966) Study of the Metabolism of Phosalone
(11974 R.P.) in Plants: R.P.—D.S.Ph. No. 11686. (Unpublished
study received Feb 2, 1967 under 7G0575; prepared by Societe des
Usines Chimiques Rhone-Poulenc, submitted by Chipman Chemical
Co., Inc., Burlingame, Calif.; CDL:090727-E)
000006203 Donoso, J.; Woodard, M.W.; Woodard, G. (1967) Phosalone: Safety
Evaluation by Repeated Oral Administration to Dogs for 107
Weeks. (Unpublished study received Oct 17, 1967 under 7G0575;
prepared by Woodard Research Corp., submitted by Chipman Chemi-
cal Co., Inc., Burlingame, Calif.; CDL:090731-A)
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006643 Dubost, P.; Fournel, J.; Ganter, P.; Julou, L.; Koenig, F.; Myon,
J.; Bredenbac, J.; Lemoine, F. (1963) Acute Toxicity, Local Tol-
erance, Anticholinesterase Activity and Chronic Toxicity in Rats
and Dogs: R.P.—D.S.Ph. 9203. (English translation; unpublished
study received 1965 under 359-EX-46; prepared by Societe des
Usines Chimiques Rhone-Poulenc, submitted by Rhone-Poulenc,
Inc., Monmouth Junction, N.J.; CDL:123396-D)
005015711 Eckenrode, C.J.; Robbins, P.S.; Webb, D.R. (1975) 1974 Insecticide
Research Report on Cabbage Maggot, Seedcorn Maggot, Aphids on
Lettuce, and Phytotoxicity in Cucumbers. Geneva, N.Y.: New
York State Agricultural Experiment Station. (New York State
Agricultural Experiment Station, plant sciences: entomology
(Geneva), no. 9; New York's food and life sciences bulletin no.
56)
005013895 FAO Working Party of Experts on Pesticide Residues (1973)
Phosalone. Pages 493-520, In 1972 Evaluations of Some
Pesticide Residues in Food. By the Joint Meeting of the FAO
Working Party of Experts on Pesticide Residues and the WHO
Expert Committee on Pesticide Residues. Geneva, Switzerland:
World Health Organization. (WHO pesticide residues series no.
2)
000006684 Fournel, J.; Ganter, P.; Julou, L.; Populaire, P.; Myon, J.;
Pascal, S.; Pasquet, J. (1966) Phosalone (11974 R.P.): Toxicity
after 6 Months Administration to Dogs: R.P.—D.S.Ph. No. 11410.
(Unpublished study received Dec 12, 1966 under 7G0575; prepared
by Societe des Usines Chimiques Rhone-Poulenc, submitted by
Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090728-C)
000006716 Fournel, J.; Julou, L.; Pasquet, J.; Bredenbac, J. (1968) 12244
R.P.: Acute Toxicity in Mice and Rats and in Vivo Anti-Choli-
nesterase Activity in Rats: R.P.—D.S.Ph. No. 12663. (Unpub-
lished study received Jun 14, 1968 under 8F0668; prepared by
Societe des Usines Chimiques Rhone-Poulenc, submitted by Chip-
man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-AL)
005018633 Freed, V.H.; Chiou, C.T.; Schmedding, D.; Kohnert, R. (1979) Some
physical factors in toxicological assessment tests.
Environmental Health Perspectives 30:75-80.
GS0027019 Goldenthal, E.I.; Jessup, D.C.; Rodwell, D.E. (1978) Dominant
Lethal Study in Mice. (Unpublished study received Dec 12, 1980
under 6F1753; prepared by International Research and Development
Corp., submitted by Rhone-Poulenc, Inc., Monmouth Juntion, NJ;
CDL:099788)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006657 Grahame, R.E., Jr. (1967) The Conparative Toxicity of Selected
Organic Phosphate and Carbamate Insecticides to the Honey Bee.
Master's thesis, Univ. of Massachusetts. (Unpublished study re-
ceived Nov 17, 1975 under 359-620; submitted by Rhone-Poulenc,
Inc., Monmouth Junction, N.J.; CDL:223344-K)
000006383 Guardigli, A. (1964) Chemical Determination of R-P-11974 (Phosa-
lone) for Crop Residues. Method no. 54 dated Oct 2, 1964. (Un-
published study received Feb 2, 1967 under 7G0575; submitted by
Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090727-A)
000006389 Guardigli, A. (1964) Laboratory Analytical Data Sheet for Residues
of R.P. 11974: Phosalone. (Unpublished study received Feb 2,
1967 under 7G0575; prepared by Rhodia, Inc., submitted by Chip-
man Chemical Co., Inc., Burlingame, Calif.; CDL:090727-H)
000006769 Guardigli, A. (1964) Laboratory Analytical Data Sheet for Residues:
Field Test Project No. BB 64-26. (Unpublished study received
Feb 2, 1967 under 7G0575; prepared by Rhodia, Inc., submitted
by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090727-L)
000006388 Guardigli, A. (1965) Residue Summary Sheet: [Phosalone]. (Unpub-
lished study including project nos. BB 10-64-12, BB 12-64-20,
BB 64-26, BB 65-18, BB 65-27, BB 65-47, BB 65-49, BB 65-127,
C 64-12, C 65-17, C 65-30 and Port 65-47, received Feb 2, 1967
under 7G0575; prepared by Rhodia, Inc., submitted by Chipman
Chemical Co., Inc., Burlingame, Calif.; CDL:090727-G)
000006391 Guardigli, A. (1966) Laboratory Analytical Data Sheet for
Residues: Field Test Project No. BB 66-126. (Unpublished study
received Feb 2, 1967 under 7G0575; prepared by Rhoda, Inc.,
submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
CDL:090727-J)
000006714 Guardigli, A. (1966) Laboratory Raw Analytical Data. (Unpublished
study including letter dated Feb 9, 1965 from L. Farber to L.
Reed and test nos. BB-64-26, BB-65-125, C-64-12, C-65-27, Port-
65-66 and Port 66-12, received Jun 14, 1968 under 8F0668; pre-
pared by Rhodia, Inc., submitted by Chipman Chemical Co., Inc.,
Burlingame, Calif.; CDL:091171-AD)
000006392 Guardigli, A. (1966) Residue Summary Sheet: [Phosalone]. (Unpub-
lished study including project nos. BB 64-26, BB 65-125, C 64-
12, C 65-27, Port 65-66 and Port 66-12, received Feb 2, 1967
under 7G0575; prepared by Rhodia, Inc., submitted by Chipman
Chemical Co., Inc., Burlingame, Calif.; CDL:090727-K)
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006390 Guardigli, A. (1966) Residue Summary Sheet: [Phosalone]. (Unpub-
lished study including project nos. C-64-12 and BB-65-63, re-
ceived Feb 2, 1967 under 7G0575; prepared by Rhodia, Inc., sub-
mitted by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:
090727-1)
000006395 Guardigli, A. (1966) Residue Summary Sheet: [Phosalone]. (Unpub-
lished study including project nos. C 64-16, C 65-44, BB 65-42
and BB 65-51, received Feb 2, 1967 under 7G0575; prepared by
Rhodia, Inc., submitted by Chipman Chemical Co., Inc., Burlin-
game, Calif.; CDL:090727-0)
000006129 Guardigli, A. (1967) Analytical Procedure for Phosalone Residue
Determination in Milk and Animal Tissues by Electron Capture
Chromatography. Method no. 54-C dated Aug 14, 1967. (Unpub-
lished study received Oct 17, 1967 under 7G0575; prepared by
Rhodia, Inc., submitted by Chipman Chemical Co., Inc., Burlin-
game, Calif.; CDL:090733-B)
000006713 Guardigli, A. (1967) Laboratory Raw Analytical Data. (Unpublished
study including letter dated Mar 2, 1965 from L. Farber to L.
Reed and field test project nos. BB-65-63, BB-67-100, C 64-12,
and PA 67-28, received Jun 14, 1968 under 8F0668; prepared by
Rhodia, Inc., submitted by Chipman Chemical Co., Inc.,
Burlingame, Calif.; CDL:091171-Z)
000006703 Guardigli, A. (1968) Determination of RP 11974 (Phosalone) for Crop
Residue by Electron Capture Chromatography. Rev. Method no.
54-A dated Mar 20, 1968. (Unpublished study received Jun 14,
1968 under 8F0668; prepared by Rhodia, Inc., submitted by Chip-
man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-D)
GS0027014 Guardigli, A. (1968) [Phosalone residue analyses on citrus and
nut crops. (Unpublished study received Apr 19, 1968 under
OF0948 Part D; submitted by Rhodia, Inc.)
GS0027015 Guardigli, A. (1968) [Phosalone residue analyses on citrus and nut
crops.] (Unpublished study received Apr 19, 1968 (PA66-63) and
Sep 26, 1969 (PA66-73) under OF0948; submitted by Rhodia, Inc.)
GS0027016 Guardigli, A. (1968) [Phosalone residue analyses on citrus and nut
crops.] (Unpublished study received Apr 19, 1968 (PAS66-57),
Oct 10, 1969 (PA69-19), Oct 6, 1969 (PA69-19), Feb 6, 1970 (PA19-
19), Jan 22, 1970 (PA69-19), Oct 6, 1969 (PA69-19 Decline
Series), and Dec 15, 1969(Westlake Report, University of
California at Riverside) under OF0948; submitted by Rhodia, Inc.)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
GS0027010 Guardigli, A. (1968) Rhodia Analytical Method No. 54-D.
Quantitative Determination of Phosalone by GLC and Semi-
Quantitative Determination of RP 1224 (Phosalone Oxygen
Analog) in Crop Extracts by Thin Layer Chromatography.
[Unpublished report based on Rhone-Poulenc D.S. Ph. No. 12773.]
foliage. Bull. Environm. Contam. Toxicol. 24: 796-804.
000006711 Guardigli, ^A. (1968) Results of Tests on the Amount of Residue Re-
maining. (Unpublished study including letters dated Dec 9,
1964, Jan 21, 1965 and Oct 1, 1965 from L. Farber to L. Reed
and field test nos. BB-10-64-12, BB-64-10, BB-64-26, BB-65-47,
BB-65-49, BB-65-127, C-64-12, C-65-17; C-65-30, C-66-32,
C-66-33, PA-66-32, PA-67-58 and Port-65-47, received Jun 14,
1968 under 8F0668; prepared by Rhodia, Inc., submitted by Chip-
man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-N)
000006170 Guardigli, A. (1968) Specific Analytical Method for Phosalone
Liquid Formulations (Zolone E.G.): Determination by Gas Liquid
Chromatography. Method no. 54-A dated May 1968. (Unpub-
lished study received Jan 16, 1969 under 359-620; prepared by
Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, N.J.; CDL:124065-A)
000006640 Guardigli, A. (1969) Determination of RP 11974 (Phosalone) in Wet-
table Powder Formulation. Method no. 54-A 2 dated Dec 1969.
(Unpublished study received Dec 22, 1969 under 359-626; prepared
by Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:003174-AF)
000006762 Guardigli, A. (1971) Method of Analysis of Phosalone and Its Oxygen
Analog (RP 12244) in Animal Tissues by TLC. Method no. 54-C 1
dated Jun 1, 1971. (Unpublished study received Jun 26, 1972
under OF0983; submitted by Rhodia, Inc., New Brunswick, N.J.;
CDL:091691-1)
000006068 Guardigli, A. (1972) Phosalone Transfer in Fruits Processing:
Possible Residue in Raw Apple Juice and Dry Apple Pomace: Labo-
ratory Experiments. (Unpublished study received Feb 16, 1972
under 2H5013; submitted by Rhodia, Inc., New Brunswick, N.J.;
CDL:221747-C)
000006105 Guardigli, A. (1973) Electron Capture Gas Liquid Chromatography
Determination of Phosalone and Its Oxygen Analog in the Milk
and Tissues of Dairy Cattle. Revised Method 54-C dated Apr
1973. (Unpublished study received May 15, 1973 under 2F1193;
submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:093518-AC)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006971 Guardigli, A. (1973) Residue Studies in the Milk and Tissues of
Dairy Cows Fed Phosalone. (Unpublished study received Mar 4,
1976 under 6F1753; submitted by Rhodia, Inc., Monniouth Junction,
N.J.; CDL:098088-L)
005008180 Guardigli, A.; Chow, W.; Martwinski, P.M.; Lefar, M.S. (1971)
Determination of phosalone and its oxygen analog in citrus
crops. Journal of Agricultural and Food Chemistry
19(4):742-744.
000006783 Guardigli, A.; Martwinski, P. (1969) Phosalone Residues on Apples
Treated with Zolone 25% Wettable Powder at Several Application
Rates. (Unpublished study including field test project nos. AT
69.16-AT 69.17, BB 68-66, BB 69.7-BB 69.9, Port 68-12 and Port
69-56, received Dec 22, 1969 under 359-626; prepared by Rhodia,
Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.;
CDL:003174-W)
000006358 Guardigli, A.; Martwinski, P. (1970) Results of Almond Residue
Tests: Part D. (Unpublished study including field test project
nos. PAW 69-5, PAW 69-6, PAW 69-9, PAW 69-13, PAW 69-18 and PAW
68-18, received Jun 26, 1972 under OF0983; submitted by Phodia,
Inc., New Brunswick, N.J.; CDL:091691-J)
000006511 Guardigli, A.; Martwinski, P. (1970) Results of Residue Tests.
(Unpublished study including report nos. AT 69-14, AT 69-20, AT
69-22, AT 69-47, PA 67-45, PA 68-50, PA 69-29, PAS 67-77, PAW
69-2 and PAW 69-7, received Mar 12, 1970 under OF0948; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:091617-B)
000006480 Guardigli, A.; Martwinski, P. (1971) Residue Data: [Zolone]. (Un-
published study including field test project nos. BB 65-63, BB
68-91, PA 68-46, PA 70-25/25A, PA 70-26, PA 70-27/27A and PAW
70-29, received Nov 18, 1971 under 359-626; prepared by Rhodia,
Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.;
CDL:003175-X)
000006576 Guardigli, A.; Martwinski, P. (1972) Phosalone—Potato Petition:
Residue Summary—Potatoes. (Unpublished study including field
test project nos. AT 71-15, BB 68-87, BB 68-94, BB 69-60, C 66-
41, CH 71-61, CH 71-84, CH 71-103, FW 71-52 and Port 71-30,
received May 25, 1973 under 3F1337; submitted by Rhodia, Inc.,
New Brunswick, N.J.; CDL:093575-E)
000006083 Guardigli, A.; Melkesian, B. (1968) Detection of Metabolites in
Grapes Sprayed with Excessive Amounts of Phosalone (PA-68-30).
(Unpublished study received Sep 12, 1968 under 9F0759; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:091306-AC)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006084 Guardigli, A.; Rock, G. (1968) Detection of the Oxygen Analog (RP
12244) in Apples (AT-68-10). (Unpublished study received Sep
12, 1968 under 9F0759; prepared in cooperation with North
Carolina State Univ., submitted by Rhodia, Inc., New Brunswick,
N.J.; CDL:091306-AD)
000006678 Guardigli, A.; Taschenberg, E.F.; Stafford, E.M. (1967) Laboratory
Analytical Data Sheet for Residues: Field Test Project No. BB
67-100. (Unpublished study including field test project no. PA
67-25, received Jun 14, 1968 under 8F0668; prepared by Rhodia,
Inc., submitted by Chipman Chemical Co., Inc., Burlingame,
Calif.; CDL:091170-F)
000006964 Henckler, P. (1973) Project Number 170473-008. (Unpublished study
including letter dated Nov 6, 1973 from D.I. Wang to C.C. Comp-
ton, received Oct 18, 1973 under 3E1401; prepared by Rhodia,
Inc., submitted by Interregional Research Project No. 4, New
Brunswick, N.J.; CDL:098195-A)
000006107 Henckler, P. (1973) Specific Analytical Method for Technical Phosa-
lone and Its Formulations: Liquid and Wettable Powders. Method
no. 124 dated Nov 1973. (Unpublished study received Mar 4, 1976
under 6F1753; submitted by Rhodia, Inc., Monmouth Junction,
N.J.; CDL:095979-D)
000006483 Henckler, P.M.; Dennis, S. (1973) Residue Summary: Apricots. (Un-
published study including residue final report nos. 170473-042
and 170473-053, received Mar 29, 1974 under 359-620; prepared by
Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, N.J.; CDL:028124-C)
000006484 Henckler, P.M.; Dennis, S.; Collins, R. (1973) Residue Summary:
Cherries. (Unpublished study including residue final report
nos. 170473-041 (A), 170473-041. (B) and 213673-013, received Mar
29, 1974 under 359-620; prepared by Rhodia, Inc., submitted by
Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:028124-D)
000006485 Henckler, P.M.; Rice, R. (1973) Residue Summary: Nectarines: Pro-
ject No. 180473-032. (Unpublished study received Mar 29, 1974
under 359-620; prepared by Rhodia, Inc. in cooperation with
Univ. of California, submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:028124-E)
000006487 Henckler, P.M.; Rice, R. (1973) Residue Summary: Plums: Project
No. 180473-033. (Unpublished study received Mar 29, 1974 under
359-620; prepared by Rhodia, Inc. in cooperation with Univ. of
California, submitted by Rhone-Poulenc, Inc., Monmouth Junction,
N.J.; CDL:028124-G)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006486 Henckler, P.M.; Taylor, J.C.; Corner, G.; Dennis, S. (1973) Residue
Summary: Peaches. (Unpublished study including residue final
report nos. ARK 72-77, 123973-023 and 170473-072, received Mar
29, 1974 under 359-620; prepared by Rhodia, Inc. in cooperation
with Louisiana State Univ. and Clernson Univ., submitted by
Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:028124-F)
000006689 Horn, H.J.; Woodard, M.W.; Woodard, G. (1965) Phosalone R.P. 11974:
Acute Dermal Toxicity for Rabbits. (Unpublished study received
Dec 15, 1966 under 7G0575; prepared by Woodard Research Corp.,
submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
CDL:090729-D)
000006690 Horn, H.J.; Woodard, M.W.; Woodard, G. (1965) Phosalone R.P. 11974:
Acute Eye Irritation in Rabbits. (Unpublished study received
Dec 15, 1966 under 7G0575; prepared by Woodard Research Corp.,
submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
CDL:090729-E)
005006342 Ishitani, A.; Yukimoto, M.; Yoshida, K. (1975) Nogaku no
kakushusakubutsu ni taisuru yakugai ni tsuite: II. Yuki rinkei
satchuzai. [Phytotoxicities of agricultural chemicals to
crops: II. Organophosphorus insecticides.] Noyaku Kensasho
Hokoku. [Bulletin of the Agricultural Chemicals Inspection
Station.] (15):92-97.
000006204 Jones, M.E. ; Post, K.F..; Scott, W.J.; Woodard, M.W. ; Woodard, G.
(1967) Phosalone: Three-Generation Reproduction Study in the
Rat. (Unpublished study received Oct 17, 1967 under 7G0575;
prepared by Woodard Research Corp., submitted by Chipman Chemi-
cal Co., Inc., Burlingame, Calif.; CDL:090732-A)
000006205 Jones, M.E.; Woodard, M.W.; Imming, R.J.; Woodard, G. (1967) Phos-
alone Followed by a Determination of Potentiation Activity with
the Compound Di-Syston. (Unpublished study received Oct 17,
1967 under 7G0575; prepared by Woodard Research Corp., submitted
by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090734-A)
005020178 Karg, W. (1978) Untersuchungen zur Selektivitaet von
Pflanzenschutzmitteln im Hinblick auf nuetsliche, Spinnmilben
vertilgende Raubmilben im Obsthau. [Investigation on thhe
selectivity of plant protection chemicals with regard to
beneficial predatory mites destroying spider mites in orchards.]
Archiv fuer Phytopatholigie und Pflanzenschutx 14(1):41-55,
005008254 Khera, K.S.; Whalen, C.; Angers, G.; Trivett, G. (1979) Assessment
of the teratogenic potential of piperonyl butoxide, biphenyl,
and phosalone in the rat. Toxicology and Applied Pharmacology
47(2):353-358.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
005014548 Klisenko, M.A.; Pis'mennaya, M.V. (1973) Vliyanie UF-sveta na
stabil'nost1 dialkilditiofosfororganicheskii pestitsidov. [The
effect of ultraviolet light on the stability of
dialkyldithioorganophosphorus pesticides.] Khimiya v Sel'skom
Khozyaistve. [Chemistry in Agriculture.] 11(12):916-918.
GS0027027 Knaak, J.B. (1980) Minimizing occupational exposure to pesticides:
Techniques for estimating safe levels of foliar residues. Pages
81-96, In Residue Reviews, Volume 75. By F.A and J.D.
Gunther, editors. New York: Springer-Verlag New York Inc.
005008190 Knaak, J.B.; Maddy, K.T.; Gallo, M.A.; Lillie, D.T.; Craine, E.M.;
Serat, W.F. (1978) Worker reentry study involving phosalone
application to citrus groves. Toxicology and Applied
Pharmacology 46(2):363-374.
005003635 Knaak, J.B.; Peoples, S.A.; Jackson, T.J.; Fredrickson, A.S.;
Enos, R.; Maddy, K.T.; Blair Bailey, J.; Duesch, M.E.; Gunther,
F.A.; Winterlin, W.L. (1978) Reentry problems involving the use
of dialifor on grapes in the San Joaquin Valley of California.
Archives of Environmental Contamination and Toxicology
7(4):465-481.
000006938 Knobel, H.; Rock, G. (1969) Summary Report: District Project No. AT
69-16. (Unpublished study received Dec 22, 1969 under 359-626;
prepared in cooperation with North Carolina State Univ., Dept.
of Entomology, submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, N.J.; CDL:003174-R)
000006939 Knobel, H.; Rock, G. (1969) Summary Report: District Project No. AT
69-17. (Unpublished study received Dec 22, 1969 under 359-626;
prepared in cooperation with North Carolina State Univ., Dept.
of Entomology, submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, N.J.; CDL:003174-S)
005014688 Kovaleva, E.S.; Talanov, G.A. (1977) Absorptsiya TKhM-3 i fozalona
iz pochvy i ikh migratsiya v rasteniya. [Trichlorometaphos-3
and phosalone absorption from the soil and their migration into
plants.] Gigiena i Sanitariya. [Hygiene and Sanitation.]
42(12):87-88.
000006067 Laurent, ?; Buys, ?; Aublet, ?; Bottreau, ? (1975) Phosalone:
Solubility and Stability in Water: R.P./R.D./C.N.G.—An
No. 2793. (English translation; unpublished study received Sep
29, 1975 under 359-620; prepared by Societe des Usines Chimiques
Rhone-Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:094857-A)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006645 Laurent, M. (1964) Methods of Identification and Estimation of
Phosalone. Three methods dated Oct 7, 1963. (English transla-
tion; unpublished study received 1965 under 359-EX-46; prepared
by Societe des Usines Chimiques Rhone-Poulenc, submitted by
Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:123396-F)
000006700 Laurent, M.; Aublet, J.C.; Sasmayoux, J.C. (1967) Phosalone: Method
of Determination of Phosalone Residues in Plants by Gas-Liquid
Chromatography: R.P.—D.S.Ph. No. 11791. Method dated Feb 3,
1967. (Unpublished study received Jun 14, 1968 under 8F0668;
prepared by Societe des Usines Chimiques Rhone-Poulenc, sub-
mitted by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:
091171-A)
000006665 Laurent, M.; Buys, M.; Chabassol, Y.; Sauli, M.; Brunie, B. ; Ray-
naud, L.; DePaire, H.; Snozzi, C.; Kretz, M.; Bisch, D. (1977)
Phosalone (11974 R.P.): Photodegradation in the Water-Dissolved
State: R.P./R.D./C.N.G.-An—Report No. 3131. (Unpublished study
received May 10, 1977 under 359-620; prepared by Societe des
Usines Chimiques Rhone-Poulenc, submitted by Rhone-Poulenc,
Inc., Monmouth Junction, N.J.; CDL:229759-E)
000006708 Laurent, M.; Buys, M.; Sasmayoux, J.C. (1968) Phosalone: G.L.C. De-
termination of Phosalone and 12244 R.P. in Apples and in Grape
Extracts from the U.S.A.: D.S.Ph./D.S.An.Nord No. 12864. (Un-
published study received Jun 14, 1968 under 8F0668; prepared by
Societe des Usines Chimiques Rhone-Poulenc, submitted by Chip-
man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-J)
000006698 Laurent, M.; Terlain, B.; Vertalier, S. (1965) Phosalone
(RP 11974): Stability of the Bulk Product; (Control 64-R-1921):
R.P.—D.S.An. Nord—No. 151. Includes two methods dated Dec 3,
1964. (English translation; unpublished study received Dec 15,
1966 under 7G0575; prepared by Societe des Usines Chimiques
Rhone-Poulenc, submitted by Chipman Chemical Co., Inc., Bur-
lingame, Calif.; CDL:090729-N)
005007745 Leffingwell, J.T.; Spear, R.C.; Jenkins, D. (1975) The persistence
of ethion and Zolone residues on grape foliage in the Central
Valley of California. Archives of Environmental Contamination
and Toxicology 3(1):40-54.
005007744 Leffingwell, J.T.; Turner, E.R.; Futagaki, S.; Spear, R.C. (1977)
A field survey of dislodgeable Zolone residues in twelve
commercially treated vineyards. Bulletin of Environmental
Contamination and Toxicology 18(2):219-226.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006430 Lillie, D.T. (1972) Final Report: District Project No. F 72-57.
(Unpublished study received Mar 16, 1973 under 359-620; prepared
by Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Momnouth
Junction, N.J.; CDL:008914-B)
000006747 Lillie, D.T.; Carman, G. (1971) Final Report: District Project
No. FD 71-91. (Unpublished study received on unknown date under
2F1193; prepared in cooperation with Univ. of California—River-
side, submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:
093518-G)
000006748 Lillie, D.T.; Carman, G. (1971) Final Report: District Project
No. FD 71-92. (Unpublished study received on unknown date under
2F1193; prepared by Univ. of California—Riverside, submitted by
Rhodia, Inc., New Brunswick, N.J.; CDL:093518-H)
005001833 Maddy, K.T. (1976) Current considerations on the relative
importance of conducting additional studies on hazards of field
worker exposure to pesticide residues as compared to studying
other occupational safety hazards on the farm. Pages 125-
142,@In@Pesticide Residue Hazards to Farm Workers—Proceedings
of a Workshop; Feb 9-10, 1976, Salt Lake City, Utah.
Washington, D.C.: U.S. Government Printing Office. (HEW
publication no. (NIOSH) 76-191)
005011351 Makarova, S.V.; Bel'skaya, G.; Soboleva, D.A. (1972) Analiz
ftalofosa i benzofosfata iodometricheskim metodom. [Analysis
of phthalophos and benzophosphate by an iodometric titration
method.] Khimiya v Sel'skom Khozyaistve. [Chemistry in
Agriculture.] 10(5):361-362.
000006976 McGinnis, C.H., Jr. (1974) The Effect of Dietary Phosalone on Body
Weight, Feed Consumption, Reproduction and the Production of
Phosalone Residues in Body Tissues and Eggs of Single Comb White
Leghorn Chickens: Research Report No. CHM 74:121. (Unpublished
study received Mar 4, 1976 under 6F1753; submitted by Rhodia,
Inc., Monmouth Junction, N.J.; CDL:098088-Q)
005016356 Nalbandyan, R.A. (1975) 0 vozmozhnosti proniknoveniya nekotorykh
pestitsidov v yagody vinograda. [The possibility of
penetration of some pesticides into grapes.] Vinodelie i
Vinogradarstvo SSSR. [Winemaking and Viticulture in the USSR.
(6):42-43.
005005773 Nelson, E.E.; Croft, B.A.; Howitt, A.J.; Jones, A.L. (1973)
Toxicity of apple orchard pesticides to Agistemus fleschneri.
Environmental Entomology 2(2):219-222.
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006111 Noel, P.R.B.; Rivett, K.F.; Osborne, B.E.; Street, A.E. (1970)
Phosalone: Dietary Intake in Beagle Dogs for Four Weeks: Report
No. 3619/70/431. (Unpublished study received Mar 4, 1976 under
6F1753; prepared by Huntingdon Research Centre for May &
Baker, Ltd., submitted by Rhodia, Inc., Monmouth Junction,
N.J.; CDL:095979-M)
000006110 Pasquet, J.; Buisson, M. (1969) Etude de L'Activite Teratogene de
la Phosalone (11974 R.P.) sur L'Embryon de Poulet et sur la
Lapine: R.P.—D.S.Ph. No. 13447. [Study of Teratological Acti-
vity of Phosalone (RP 11974) on Chicken Embryos and Rabbits.]
(Unpublished study including English translation, received Mar
4, 1976 under 6F1753; prepared by Societe des Usines Chimiques
Rhone-Poulenc, submitted by Rhodia, Inc., Monmouth Junction,
N.J.; CDL:095979-L)
005007746 Pasquet, J.; Mazuret, A.; Fournel, J.; Koenig, F.H. (1976) Acute
oral and percutaneous toxicity of phosalone in the rat, in
comparison with azinphosmethyl and parathion. Toxicology and
Applied Pharmacology 37(1):85-92.
005005243 Popendorf, W.J.; Spear, R.C.; Leffingwell, J.T.; Yager, J.; Kahn,
E. (1979) Harvester exposure to Zolone (phosalone) residues in
peach orchards. Journal of Occupational Medicine
21(3):189-194.
000006792 Posner, S. (1971) Cow-Feeding Study with Phosalone (Technical)
Insecticide (Dairy Cattle)—Biological Phase. (Unpublished
study including letter dated Jul 26, 1971 from L.C. Brown to
Lee E. TerBush, received Jun 13, 1974 under 359-620; prepared by
Biometric Testing, Inc. for Rhodia, Inc., submitted by Rhone-
Poulenc, Inc., Monmouth Junction, N.J.; CDL:120351-T)
000006761 Posner, S. (1971) Cow-Feeding Study with Phosalone (Technical)
Insecticide (Dairy Cattle)—Biological Phase. (Unpublished
study including project no. 49-181, received Jun 26, 1972 under
OF0983; prepared in cooperation with Biometric Testing, Inc.,
submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:091691-C)
000006479 Preiser, F.A.; Taschenberg, E.F. (1968) Report No. BB 68-91. (Un-
published study received Nov 18, 1971 under 359-626; prepared
in cooperation with Cornell Univ., submitted by Rhone-Poulenc,
Inc., Monmouth Junction, N.J.; CDL:003175-T)
GS0027025 Rhodia, Incorporated, Chipman Division (?) [Dates of application
and graphs of residue data for apricots, cherries, nectarines,
peaches, and plums/prunes.] (Unpublished study received ? under
1F1155)
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006120 Rhodia, Incorporated (19??) Phosalone in Dairy Cattle Tissue: Sum-
mary. (Unpublished study received May 6, 1970 under OF0983;
CDL:093292-G)
000006113 Rhodia, Incorporated (19??) Technical Data Bulletin: Zolone: In-
secticide annd Miticide. (Unpublished study received Mar 4, 1976
under 6F1753; CDL:095979-O)
000006651 Rhodia, Incorporated (19??) Technical Data Sheet—Zolone: Insecti-
cide and Miticide. (Unpublished study received Mar 4, 1974 un-
der 359-EX-52; submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, N.J.; CDL:123398-A)
000006712 Rhodia, Incorporation (1967) Field and Analytical Data: Phosalone
Residues in Apples—Ontario, Canada—1967. (Unpublished study
received Jun 14, 1968 under 8F0668; submitted by Chipman CHemical
Co., Inc., Burlingame, Calif.; CDL:091171-x)
000006717 Rhodia, Incorporated (1967) Phosalone Feeding Test. (Unpublished
study received Jun 14, 1968 under 8F0668; prepared in coopera-
tion with Woodard Research Corp., submitted by Chipman Chemical
Co., Inc., Burlingame, Calif.; CDL:091171-AM)
000006123 Rhodia, Incorporated (1967) Summary: Analysis of Phosalone (RP
11974) Residue in Tissues of Beef Cattle and Sheep. (Unpub-
lished study received May 6, 1970 under OF0983; CDL:093292-J)
000006210 Rhodia, Incorporated (1971) Phosalone—Tea: Phosalone Residue Stud-
ies. (Unpublished study including letters dated Jul 19, 1972
from J. Metivier and P. Petrinko to Tea Research Association and
Aug 1, 1972 from B. Banerjec to Societe des Usines Chimiques
Rhone-Poulenc, received Jun 8, 1973 under 3H5038; prepared in
cooperation with Tea Research Association and United Planters
Association of Southern India; CDL:221773-B)
000006357 Rhodia, Incorporated (1972?) Phosalone Dried Apple Pomace Data.
Includes undated method. (Unpublished study received Jun 26,
1972 under OF0983; prepared in cooperation with Cornell Univ.,
New York State Agricultural Experiment Station, Dept. of Food
Science and Technology; CDL:091691-A)
000006733 Rhodia, Incorporated (1972) Effect of Zolone EC on Stone Fruits;
Phytotoxicity: Part 1. (Unpublished study including district
project nos. F 72-62, F 72-63, Port 72-27, Port 72-32 and Port
72-41, received Mar 16, 1973 under 359-620; submitted by Rhone-
Poulenc, Inc., Monmouth Junction, N.J.; CDL:096444-A)
000006172 Rhone-Poulenc, Incorporated (1966) Chemical and Physical Proper-
ties: [Phosalone]. (Unpublished study received Jul 7, 1966
under unknown admin, no.; CDL:127090-A)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
GS0027021 Rhone-Poulenc, Incorporated (1980) Lifetime Oncogenicity Study in
Mice. (Unpublished study received Dec 4, 1980 under 6F1753;
submitted by Rhone-Poulenc, Inc., Monmouth Junction, NJ;
CDL:099788)
000006697 Rivett, K.F.; Davies, V. (1966) Insecticides: Effect of Antidotes
against Poisoning by Phosalone: R.P.—D.S.Ph.—No. 11412. (Un-
published study received Dec 15, 1966 under 7G0575; prepared by
May & Baker, Ltd. for Societe des Usines Chimiques Rhone-
Poulenc, submitted by Chipman Chemical Co., Inc., Burlingame,
Calif.; CDL:090729-M)
005017962 Sauli, M., inventor; Rhone-Poulenc S.A., assignee (1975) Verfahren
zur Herstellung von
3-0,O-Diaethyldithiophosphorylmethyl-6-chlorbenzoxazolon.
3-O,O-diethyldithiophosphorylmethyl-6-chloro-benzoxazolone.]
German (Fed. Rep.) offenlegungsschrift 24 31 192. Jan 16. 5
p. Int. C1.2 C 07F 9-65.
000006688 Scott, W.J.; Bellies, R.P. (1965) Acute Oral Toxicity of a Phosa-
lone (R.P. 11974) Formulation to Rats. (Unpublished study re-
ceived Dec 15, 1966 under 7G0575; prepared by ftfcodard Research
Corp., submitted by Chipman Chemical Co., Inc., Burlingame,
Calif.; CDL:090729-B)
000006794 Scott, W.J.; Bellies, R.P. (1965) Phosalone: Potentiation Studies
in the Rat with Marketed Pesticides. (Unpublised study received
Dec 15, 1966 under 7G0575; prepared by Woodard Research Corp.,
submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
CDL:090729-1)
000006243 Smyth, E.P.; Burkhart, D. ; McCollister, E.G. (1969) Final Report:
District Project No. Port 69-19. (Unpublished study received
Mar 26, 1971 under 1F1155; submitted by Rhodia, Inc., New Bruns-
wick, N.J.; CDL:093474-L)
000006639 Smyth, E.P.; Hoyt, S. (1969) Summary Report: District Project
No. Port 69-40. (Unpublished study received Dec 22, 1969 under
359-626; submitted by Rhone-Poulenc, Inc., Monmouth Junction,
N.J.; CDL:003174-Q)
000006793 Smyth, E.P.; Johansen, C. (19??) Report No. Port 68-67. (Unpub-
lished study received Jun 13, 1974 under 359-620; prepared in
cooperation with Washington State Univ., submitted by Rhone-
Poulenc, Inc., Monmouth Junction, N.J.; CDL:120351-X)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006283 Smyth, E.P.; Jones, S.C. (1970) Final Report: District Project
No. Port 70-22. (Unpublished study received Mar 26, 1971 under
1F1155; prepared in cooperation with Oregon State Univ., Ento-
mology Dept., submitted by Rhodia, Inc., New Brunswick, N.J.;
CDL:093474-BD)
000006943 Societe des Usines Chimiques Rhone-Poulenc (19??) [Infra-Red Spec-
trum and Ultra-Violet Spectrum of Phosalone]. (Unpublished
study received 1965 under 359-EX-46; submitted by Rhone-Poulenc,
Inc., Monmouth Junction, N.J.; CDL:123396-C)
000006398 Societe des Usines Chimiques Rhone-Poulenc (1966) Phosalone: Chro-
ma tog raphical Analysis: R.P.—D.S.Ph. No. 11345. (Unpublished
study received Feb 2, 1967 under 7G0575; submitted by Chipman
Chemical Co., Inc., Burlingame, Calif.; CDL:090727-S)
000006701 Societe des Usines Chimiques Rhone-Poulenc (1968) Phosalone: Iden-
tification of Phosalone in Plant Extracts: R.P.—
D.S.Ph. No. 12642. Includes two methods dated Feb 20, 1968.
(Unpublished study including R.P.—D.S.Ph. No. 13021, received
Jun 14, 1968 under 8F0668; submitted by Chipman Chemical Co.,
Inc., Burlingame, Calif.; CDL:091171-B)
000006674 Societe des Usines Chimiques Rhone-Poulenc (1968) 12244 R.P.:
Oxygen Analog of Phosalone: Acute Oral Toxicity and Anticho-
linesterasic Activity in Vitro: R.P.—D.S.Ph. No. 12644. (Un-
published study received Jun 14, 1968 under 8F0668; submitted by
Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:091170-B)
000006675 Societe des Usines Chimiques Rhone-Poulenc (1968) 20650 R.P.: The
Final Metabolite of Phosalone in Plants: Synthesis, Identifica-
tion, Toxicity, Possible Presence in Plants: R.P.—
D.S.Ph. No. 12645. Includes method dated Feb 20, 1968. (Unpub-
lished study received Jun 14, 1968 under 8F0668; submitted by
Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:091170-C)
GS0028009 Societe des Usines Chimiques Rhone-Poulenc (1973) Phosalone:
Chromatography Test: Identification of Impurities. A
translation of: Examen Chromatographique Identification des
Impuretes. [S.U.C.R.P.-Document D.S. An. Nord No. 2340;
Petition No. 6F1753]
000006738 Spencer, W.T.; Hofmaster, R.N. (1974) Final Report: District
Project No. 314574-011. (Unpublished study received May 10,
1977 under 359-620; prepared by Rhodia, Inc. in cooperation
with Virginia Truck and Ornamentals Research Station, submitted
by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:229758-AY)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006593 Szabo, J.; Sleesman, J.P. (1971) Zolone EC—Potatoes: Final Report
No. CH 71-103. (Unpublished study received Dec 7, 1972 under
3F1337; prepared in cooperation with Ohio State Univ., Dept. of
Entomology, submitted by Rhodia, Inc., New Brunswick, N.J.;
CDL:094849-E)
000006592 Szabo, J.; Wells, A. (1971) Zolone EC—Potatoes: Final Report
No. CH 71-61. (Unpublished study received Dec 7, 1972 under
3F1337; prepared in cooperation with Michigan State Univ., sub-
mitted by Rhodia, Inc., New Brunswick, N.J.; CDL:094849-D)
000006073 Totman, L.C.; Greenstein, E.T.; Woodard, M.W.; Woodward, G. (1967)
Phosalone: Analysis of Residue in Milk of Dairy Cattle. (Unpub-
lished study received Oct 16, 1967 under 9F0759; prepared by
Woodard Research Corp., submitted by Rhodia, Inc., New Bruns-
wick, N.J.; CDL:093071-I)
000006071 Totman, L.C.; Imming, R.J.; Woodard, G. (1967) Phosalone: Analysis
of Compound Residue in Tissues of Beef Cattle and Sheep. (Un-
published study received Oct 16, 1967 under 9F0759; prepared by
Woodard Research Corp., submitted by Rhodia, Inc., New Bruns-
wick, N.J.; CDL:093071-E)
000006668 United States of America Standards Institute (1967) Common Name for
the Pest Control Chemical: 0,O-diethyl S-[(6-chloro-2-oxobenzo-
xazolin-3-yl)methyl] phosphorodithioate: Phosalone. New York:
USAS. (USAS K62.67-1967; also In unpublished submission re-
ceived Dec 8, 1967 under 8F0668; submitted by Chipman Chemical
Co., Inc., Burlingame, Calif.; CDL:092961-A)
GS0027006 United States Environmental Protection Agency (1972) Pharamcology
Laboratory Toxicity Report-Screening. I.D. Number 100837.
(Unpublished report concerning the acute oral toxicity of Zolone
EC on rats; prepared by the Pharmacology Laboratory, Beltsville,
MD)
GS0027004 United States Environmental Protection Agency (1972) Pharmacology
Laboratory Toxicity Report-Screening. I.D. Number 101099.
[Unpublished report concerning the acute oral toxocity of Zolone
EC to rats,-prepared by the Pharmacology Laboratory, Beltsville,
MD]
GS0027005 United States Environmental Protection Agency (1973) Pharmacology
Laboratory Toxicity Report-Screening. I.D. Number
91855.(Unpublished report concerning the acute oral toxicity of
Zolone WP on rats; prepared by the Pharmacology Laboratory,
Beltsville,MD]
-------
GS0027003
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
United States Environmental Protection Agency (1976) Report of
Analysis. Sample Number 120574. [Unpublished report
concerning the acute oral toxicity of Zolone WP on rats;
prepared by the Pharmacology Laboratory, Beltsville, MD]
000006289 Wang, D. (1970) Final Report: District Project No. PAW 70-20 and
20A. (Unpublished study received Mar 26, 1971 under 1F1155;
submitted by Rhcdia, Inc., New Brunswick, N.J.; CDL:093474-BM)
000006477 Wang, D. (1970) Final Report: District Project No. PAW 70-29.
(Unpublished study received Nov 18, 1971 under 359-626; prepared
by Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:003175-N)
000006114 Wang, D. (1970) Summary Report: District Project No. PAW 70-4c.
(Unpublished study received Sep 2, 1970 under OF0983; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:091693-C)
000006115 Wang, D. (1970) Summary Report: District Project No. PAW 70-42.
(Unpublished study received Sep 2, 1970 under OF0983; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:091693-D)
000006145 Wang, D. (1972) Final Report: District Project No. FW 72-25. (Un-
published study received Mar 16, 1973 under 359-620; prepared by
Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, N.J.; CDL:009830-C)
005013359 Watve, C.M.; Lienk, S.E. (1975) Responses of two phytoseiid mites
to pesticides used in New York apple orchards. Environmental
Entomology 4(5):797-800.
005014275 Watve, C.M.; Lienk, S.E. (1976) Toxicity of carbaryl and six
organophosphorus insecticides to Arnblyseius
fallacis and Typhlodromus pyri from New York apple orchards.
Environmental Entomology 5(2):368-370.
005001343 Winterlin, W.; Kilgore, W. ; Mourer, C. ; Mull, R.; Walker, G. ;
Knaak, J.; Maddy, K. (1978) Dislodgable residues of dialifor
and phosalone and their oxygen analogs following a reported
worker-injury incident in the San Joaquin Valley, California.
Bulletin of Environmental Contamination and Toxicology
20(2):255-260.
005009309 Winterlin, W.; Mourer, C.; Bailey, J.B. (1974) Degradation of four
organophosphate insecticides in grape tissues. Pesticides
Monitoring Journal 8(1):59-65.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Standard
000006695 Woodard, M.W. ; Cockrell, K.O.; Woodard, G. (1966) Phosalone: Demye-
lination Study in Chickens. (Unpublished study received Dec 15,
1966 under 7G0575; prepared by Woodard Research Corp., submitted
by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090729-K)
000006202 Woodard, M.W.; Howard, D.J.; Donsos, J.; Woodard, G. (1967)
Phosalone: Safety Evaluation by Repeated Oral Administration to
Rats for 103-104 Weeks. (Unpublishedstudy received Oct 17, 1967
under 7G0575; prepared by Woodard Research Corp., submitted by
Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090730-A)
000006677 Woodard, M.W.; Imming, R.J.; Thompson W.: Woodard, G. (1967)
Phosalone: Safety Evaluation by Oral Administration to Calves
for Ten Weeks. (Unpublished study received Jun 14, 1968 under
8F0668; prepared by Woodard Research Corp., submitted by Chipman
Chemical Co, Inc., Burlingame, Calif.; CDL:091170-E)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005012117 Abdel-Salam, A.M.; Kaiery, E.; Abbasy, A.M.; Assem, M.A. (1972)
Effects of granular insecticides on some pests of horse bean
and peas as well as on plant growth and root nodulation.
Zeitschrift fuer Angewandte Entomologie 70(4):408-413.
005013142 Abelentseva, G.M.; Sedykh, A.S. (1973) Fitotsidnost1 insektitsidov
dlya vskhodov pshenitsy. [The phytocidal activity of
insecticides toward wheat shoots.] Khimiya v Sel'skom
Khozyaistve. [Chemistry in Agriculture.] 11(10):756-757.
005003855 Adams, R.G.; Prokopy, R.J. (1977) The ecology of the aphid
predator, Aphidoletes aphidimyza (Cecidomyiidae: Diptera), and
the effect of pesticides on its survival in apple orchards.
Journal of the New York Entomological Society LXXXV(4):163.
005016357 Adeishvili, L.; Mamaladze, L. (1976) Pospororganuli pestitsidebis
dashlis khangrdzlioba kurkovani khekhilis potolsa da nakopshi.
in the leaves and fruit of pomaceous fruit trees.] Trudy
Institute Zashchity Rastenii, Tiflis. [Transactions of the
Institute of Plant Protection.] XXVIII:96-98.
005017295 Adeishvili, L.D.; Klisenko, M.A.; Pis'mennaya, M.V. (1976)
Dinamika umen'sheniya ostatkov pestitsidov v plodakh. [Rate of
pesticide residue reduction in fruits.] Khimiya v Sel'skom
Khozyaistve. [Chemistry in Agriculture.] 14(11):43-44.
000006491 Alabaster, J.S. (1969) Survival of fish in 164 herbicides, insecti-
cides, fungicides, wetting agents and miscellaneous substances.
International Pest Control (Mar/Apr):29-35. (Also Iri un-
published submission received Jun 13, 1974 under 359-620; sub-
mitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:
120351-L)
005013141 Aleksidze, G.N. (1969) Vliyaniya yadokhimikatov na koktsinellidy.
Sadovodstvo Vinogradarstvo i Vinodelie Moldavii.
24(4):47-48.
005015605 Aleksidze, G.N. (1971) Gardabnis raionis khekhilis bagebshi
gavrtselebuli koktsinelidebis sakheobata gamovlinebis da
skhvadaskhva preparatis matze mokmedebis shestsavlis shedegebi.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005001130
005014555
005008184
005009830
000006655
000006490
005008183
005013289
Allen, P.G. (1971) Effects of some organic phosphorus and
endosulfan seed dressings on wheat. Australian Journal of
Experimental Agriculture and Animal Husbandry 11(52):556-558.
Altay, M.; Gurkan, S. (1972) Effects of agricultural chemicals
applied to vines during flowering stage, on pollination of
varions of export grape varietis. Pages 176-177, _In Zirai
Mucadele Arastirma Yilligi. [Plant Protection Research
Annual.] Ankara, Turkey: Bolge Zirai Mucadele Arastirma
Enstitusu.
Ambrosi, D.; Helling, C.S. (1977) Leaching of oxadiazon and
phosalone in soils. Journal of Agricultural and Food Chemistry
25(1):215-217.
Ambrosi, D.; Kearney, P.C.; Macchia, J.A. (1976) Persistence and
metabolism of phosalone in soil. Abstracts of Papers of the
American Chemical Society 172:106.
Anderson, L.D.; Atkins, E.L., Jr. (1967) Toxicity of Pesticides and
Other Agricultural Chemicals to Honey Bees: Field Study. By
Univ. of California, Dept. of Entomology. Riverside, Calif.:
U.C. (Agricultural Extension Service AXT-251; also In_ unpub-
lished submission received Nov 17, 1975 under 359-620; submitted
by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:223344-E)
Anderson, L.D.; Atkins, E.L., Jr.; Nakakihara, H.; Greywood, E.A.
(1971) Toxicity of Pesticides and Other Agricultural Chemicals
to Honey Bees: Field Study. Rev. Riverside, Calif.: Univ. of
Calif., Agricultural Extension. (AXT-251; also In unpublished
submission received Jun 13, 1974 under 359-620; "submitted by
Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:120351-1)
Anon. (1973) Coming: worker re-entry regulations.
136(2):54,56.
Farm Chemicals
Antonovich, E.A.; Vekshtein, M.S. (1975) Vliyanie razlichnykh
vidov perera'otki produktov pitaniya na soderzhanie
ostatochnykh kolichestv fosfororganicheskikh pestitsidov. [The
effects of different ways of processing food produce on their
content of organophosphorus pesticide residues.] Voprosy
Pitaniya. [Problems of Nutrition.] (6):75-78.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005015386 Aoki, Y.; Takeda, M.; Uchiyama, M. (1976) Shokuhinchu no
zanryunoyaku no bunseki ni kansuru kenkyn (dai 18-ho)
gasukuromatoguratogurafi ni yoru yukirinnoyaku no
keitobunsekiho narabi ni yukirinhoyaku no enkokodokeikenshukki
ni taisuru kando ni oyobosu suiso oyobi kukirynsoku no eikyo.
Systematic analysis of organophosphorus pesticides by gas
chromatography and influence of the flow rate of hydrogen and
air on their response to flame photometric detector.] Eisei
Kagaku. [Journal of Hygienic Chemistry.] 22(2):81-90.
005013143 Arutyunova, E.V. (1977) Vliyanie antio i fozalona na razvitie
yabloni. [The effect of antio and phosalone on the development
of apple trees.] Khimiya v Sel'skom Khozyaistve. [Chemistry
in Agriculture.] 15(3):45-46.
005007035 Arzone, A. (1975) Indagini e proposte su antiparassitari
presentati come non dannosi all'entomofauna utile.
harmless to useful insects.] Apicoltore Moderno 66(1):16-25.
005010424 Askew, J.; Ruzicka, J.H.; Wheals, B.B. (1968) Use of hydriodic
acid in the detection of pesticides after thin-layer
chromatography. Journal of Chromatography 37(2):369-372.
000009033 Asquith, D.; Colburn, R. (1973) 1973 Laboratory Evaluation of Vari-
ous Pesticides on Stethorus punctum Adults. (Unpublished study
received Mar 13, 1978 under CO 78/5; prepared by Pennsylvania
State Univ., Fruit Research Laboratory, submitted by E.I. du
Pont de Nemours & Co., Wilmington, Del.; CDL:236817-F)
005001682 'Asquith, D.; Hull, L.A. (1973) Stethorus punctum and
pest-population responses to pesticide treatments on apple
trees. Journal of Economic Entomology 66(5):1197-1203.
005013145 Babii, V.S.; Tsvetkova, A.G. (1972) Reaktsiya yabloni na raznye
kontsentratsii pestitsidov pri maloob'emnom opryskivanii. [The
reaction of apple trees to different pesticide concentrations
in low volume spraying.] Khimiya v Sel'skom Khozyaistve.
005012841 Bailey, J.B. (1972) The effects of pesticide residues on farm
laborers. Agrichemical Age 15(10):6-8,10.
000006691 Bellies, R.P.; Knott, W.; Scott, W.J. (1965) Safety Evaluation of
Phosalone (R.P. 11974) in Fish and Wildlife (Bobwhite Quail,
Mallard Ducks, Rainbow Trout, Bluegill Sunfish, Goldfish and
Oysters). (Unpublished study received Dec 15, 1966 under
7G0575; prepared by Woodard Research Corp., submitted by Chipman
Chemical Co., Inc., Burlingame, Calif.; CDL:090729-F)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005015128 Berim, N.G.; Bykhovets, A.I. (1973) Izraenenie gazoobmena
cheshuekrylych nasekomykh pri kohtaktnom otravlenii sevinom,
ftalofosom i fozalonon. [Change in gas metabolism of
Lepidoptera during contact poisoning by Sevin, phthalophos, and
phosalone.] Zapiski Leningradskogo Sel'skokhozyaistvennogo
Instituta. [Reports of the Leningrad Agricultural Institute.]
212:38-41.
005016358 Biro, L.; Nagy, B. (1974) Fozalon meghatarozasa spektrofotometriai
modszerekkel. [Determination of phosalone by
spectrophotometric methods.] Nehezvegyipari Kutato Intezet
Kozlemenyei. [Communications of the Research Institute for
Heavy Chemical Industry.] 5:127-133.
005013734 Blagonravova, L.N.; Karakhanova, S.V. (1974) Vliyanie pestitsidov
na biokhimicheskie protsessy v yablokakh vo vremya
osenne-zimngo khraneniya. [Effect of pesticides on biochemical
processes in apples during autumn-winter storage.] Khimiya v
Sel'skom Khozyaistve. [Chemistry in Agriculture.]
12(3):202-204.
005013733 Blagonravova, L.N.; Karakhanova, S.V.; Kriventsov, V.I. (1974)
Vliyanie khimicheskikh preparatov, primenyaemykh v period
vegetatsii yabloni, na kachestvo yablok vo vremya
osenne-zimnego khraneniya. [Effect of chemical preparations
used during the vegetation period of an apple tree on the
quality of apples during autumn-winter storage.] Khimiya v
Sel'skom Khozyaistve. [Chemistry in Agriculture.]
12(6):442-444.
005006362 Bournoville, R.; Tasei, J.N. (1977) Effets compares de quelques
insecticides sur les mirides nuisibles a la luzerne, leurs
predateurs et les apoides pollinisateurs. [Comparative effects
of some insecticides against harmful mirids of alfalfa, their
predators and the pollinating apoids.]
Phytiatrie-Phytopharmacie 26(3):185-192.
005001037 Bowman, M.C.; Beroza, M. (1970) GLC retention times of pesticides
and metabolites containing phosphorus and sulfur on four
thermally stable columns. Journal of the Association of
Official Analytical Chemists 53(3):499-508.
005018185 Buchner, R.O. (1973) Bienenvergiftungen durch Rebschutzmassnahmen
und ihre Verhuetung. [Bee poisoning caused by measures to
protect vines and its prevention.] Tieraerztliche Umschau
28(12):623-625.
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006760 Burr, R.; Baird, C. (1975) Final Report: District Project
No. 351175-065. (Unpublished study received Mar 24, 1976 under
359-620; prepared by Rhodia, Inc. in cooperation with Univ. of
Idaho, Extension, submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:095197-BJ)
000006352 Burr, R.; Burr, J. (1975) Final Report: District Project
No. 353675-060. (Unpublished study received Mar 24, 1976 under
359-620; prepared by Rhodia, Inc. in cooperation with Oregon
State Univ., Extension Service, submitted by Rhone-Poulenc,
Inc.., Monmouth Junction, N.J.; CDL:095197-BI)
000006696 Celice, J.; Fournel, J. (1966) Evaluation of Risks of Intoxication
by Phosalone (11974 R.P.) during Its Manufacture and Its Experi-
mentation in the Field: R.P.—D.S.Ph. No. 11346. (Unpublished
study received Dec 15, 1966 under 7G0575; prepared by Societe
des Usines Chimiques Rhone-Poulenc, submitted by Chipman Chemi-
cal Co., Inc., Burlingame, Calif.; CDL:090729-L)
005018286 Chakrabarti, J.; Roy, B.R.; Mojumder, K.K. (1979) Pesticidal
action and stability of phosalone in dry fish. Journal of Food
Sc ience and Technology (Mysore) 16(1):3 5.
005007529 Chepurnaya, V.I. (1975) Fitotsidnost1 nekotorykh pestitsidov dlya
persika. [Phytocidal activity of certain pesticides for
peaches.] Khimiya v Sel'skom Khozyaistve. [Chemistry in
Agriculture.] 13(1):34-36.
000011464 Cherry, E.T. (1977) Biological Research Report on Insecticide Ef-
ficacy and Crop Safety: Supracide 2E for Insect Control on Arti-
chokes: R&D Objective: 303018. Summary of studies 096254-B
through 096254-D, 096254-F, 096254-H through 096254-K, 096254-M
and 096254-N. (Unpublished study received Jul 19, 1977 under
100-501; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
096254-A)
005016118 Chevrel, J. (1964) Un nouvel insecticide polyvalent: la phosalone.
Vegetaux 18(106):6-11.
005016026 Chikov, V.I.; Bulka, M.Y.; Lozovaya, V.V. (1972) Vliyanie
insektitsidov na raspredeleniye C-14 v produktakh fotosinteza.
photosynthesis products.] Fiziologiya Rastenii. [Plant
Physiology.] 19(1):190-193.
005015135 Chikov, V.I.; Lozovaya, V.V. (1973) Vliyanie insektitsidov na
postfotosinteticheskii metabolizm C14-assimilyatov v list'yakh
bobov. [The effect of insecticides on the post-photosynthetic
metabolism of 14C-labelled assimilates in broad bean leaves.]
Fiziologiya Rastenii. [Plant Physiology.] 20(2):317-320.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005001452 Chiou, C.T.; Freed, V.H.; Schmedding, D.W.; Kohnert, R.L. (1977)
Partition coefficient and bioaccumulation of selected organic
chemicals. Environmental Science and Technology 11(5):475-478.
000006401 Chipman Chemical Company, Incorporated (19??) The Name, Chemical
Identity, and Composition of the Pesticide Chemical: [Phosa-
lone]. (Unpublished study received Mar 6, 1967 under 7G0575;
CDL:092863-C)
000006993 Chipman Chemical Company, Incorporated (1964) Chipman Products
Data: Experimental Insecticide R.P. 11974: Technical Data Sheet
TD/9/64. (Unpublished study received Apr 17, 1964 under 7G0575;
prepared in cooperation with Rhone-Poulenc Chemical Co.; CDL:
090736-CR)
000006387 Chipman Chemical Company, Incorporated (1966) Results of Tests on
the Amount of Residue Remaining: [Phosalone]. (Unpublished
study received Feb 2, 1967 under 7G0575; CDL:090727-F)
000006661 Chipman Chemical Company, Incorporated (1967) Safety to Honey Bees:
Technical Bulletin. 4th ed. (pp. 5-6 only; unpublished study
received Nov 17, 1975 under 359-620; submitted by Rhone-Poulenc,
Inc., Monmouth Junction, N.J.; CDL:223344-O)
000014256 Ciarletta, J.A.; Smith, R.L.; Sleesman, J.; et al. (1975) Moni-
tor (R): Efficacy, Phytotoxicity and Yield Effects on Peppers.
(Unpublished study including report nos. 31525, 31659, 31726,
31735, 32153, 36254, 36258, 36259, 36337, 36342, 36345, 36346,
39118, 39140, 39799, 40064, 40729, 40946, 41098, 42715, 42880,
42916, 43225, 43379 and 44930, received Aug 24, 1978 under 3125-
280; submitted by Mobay Chemical Corp., Agricultural Div.,
Kansas City, Mo.; CDL:097315-A)
000006397 Coad, B.R. (1965) Report on an Evaluation of Possible Personal
Hazard in Aircraft Applications of Zolone on Cotton Fields.
(Unpublished study received Feb 2, 1967 under 7G0575; prepared
by Delta Air Lines, Inc., submitted by Chipman Chemical Co.,
Inc., Burlingame, Calif.; CDL:090727-R)
000006687 Cockrell, K.O.; Woodard, M.W.; Woodard, G. (1965) Phosalone
R.P. 11974: Acute Oral LD-50 In Dogs. (Unpublished study re-
ceived Dec 15, 1966 under 7G0575; prepared by Woodard Research
Corp., submitted by Chipman Chemical Co., Inc., Burlingame,
Calif.; CDL:090729-A)
005004007 Colburn, R.; Asquith, D. (1971) Tolerance of the stages
of Stethorus punctum to selected insecticides and miticides.
Journal of Economic Entomology 64(5):1072-1074.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005008433 Colburn, R.; Asquith, D. (1973) Tolerance of Stethorus
Economic Entomology 66(4):961-962.
000006978 Collins, R.F.; Roxburgh, J. (1967) Phosalone (11,974 R.P.): Studies
of Levels in the Skin and Edible Tissues of Sheep: Gas-Liquid-
Chroma tog raphy (G.L.C.) Determinations: BIOCHEM/353. (Unpub-
lished study received Mar 4, 1976 under 6F1753; prepared by May
& Baker, Ltd., submitted by Rhodia, Inc., Monmouth Junction,
N.J.; CDL:098088-V)
000006384 Courteix, J.; Desmoras, J.; Laurent, M.; Metivier, J.; Terlain,
B. (1966) Phosalone: Methods of Analysis and Degradation of
Residues: R.P.—D.S.Ph. No. 10988. Includes six methods dated
Jan 11, 1966. (Unpublished study received Feb 2, 1967 under
7G0575; prepared by Societe des Usines Chimiques Rhone-Poulenc,
submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
CDL:090727-C)
000006972 Craine, E.M. (1974) Disposition of Phosalone-14C in a Lactating
Cow: Research Report No. EMC 74:17. (Unpublished study received
Mar 4, 1976 under 6F1753; submitted by Rhodia, Inc., Monmouth
Junction, N.J.; CDL:098088-M)
000006735 Crouch, R.V. (1970) Phosalone (11974 R.P.): Residue Studies on Tea
(Green Leaf): Pakistan 1969: Report No. RG/758. (Unpublished
study received Jun 8, 1973 under 3H5038; prepared by May &
Baker, Ltd., submitted by Rhodia, Inc., New Brunswick, N.J.;
CDL:221773-H)
000006130 Crowley, G.; Smith, M. (1973) Final Report: District Project
No. PAS 72-75. (Unpublished study including letter dated Mar
15, 1973 from L.C. Brown to P.C. Critchlow, received Mar 16,
1973 under 359-620; prepared by Rhodia, Inc. in cooperation with
Texas A & M Univ., submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:009830-A)
000006163 Davis, C.S.; Horn, R.; Van den Bosch, R.; Barnes, M.M.; Sibbett,
G.S.; Jeter, R.B.; Charles, F.M. (1972) Impact, reports, obser-
vations on the Trioxys pallidus. Diamond Walnut News
(Feb):8,23. (Also In unpublished submission received Aug 27,
1973 under 359-620; submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:026725-P)
000012551 Davis, D.W. (1967) Alfalfa Weevil Research. (Incomplete study; un-
published study received May 8, 1970 under OF0892; prepared by
Utah State Univ., submitted by Geigy Chemical Corp., Ardsley,
N.Y.; CDL:091543-AC)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006528 DeLay, D.L. (1968) Report No. PA 68-43. (Unpublished study re-
ceived Feb 16, 1970 under OF0948; submitted by Rhodia, Inc., New
Brunswick, N.J.; CDL:092026-H)
000006569 DeLay, D.L. (1969) Summary Report: District Project No. PA 69-15.
(Unpublished study received Feb 16, 1970 under OF0948; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:092026-BB)
000006534 Delay, D.L. (1969) Summary Report: District Project No. PA 69-29.
(Unpublished study received Feb 16, 1970 under OF0948; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:092026-Q)
000006237 DeLay, D.L. (1970) Final Report: District Project No. PA 70-23 &
23A. (Unpublished study received Mar 26, 1971 under 1F1155;
submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:093474-D)
000006069 Dennis, S. (1973) Phosalone—Dried Grape Pomace Data. Includes
undated method. (Unpublished study including residue final re-
port no. 170473-092, received Jul 26, 1974 under 5H5058; sub-
mitted by Rhodia, Inc., Somerset, N.J.; CDL:221786-A)
000006209 Desmoras, J.; Buys, M.; Laurent, L. (1973) Phosalone Residues in
Tea: S.U.C.R.P.—D.S.Ph./D.S.An.Nord No. 17389. (Unpublished
study received on unknown date under 3H5038; prepared by Societe
des Usines Chimiques Rhone-Poulenc, submitted by Rhodia, Inc.,
New Brunswick, N.J.; CDL:221773-A)
005017655 Desmoras, J.; Fournel, F.; Laurent, M.; Sauli, M.; Terlain, B.
(1971) Etude de la vitesse de degradation de la phosalone dans
le sol, les plantes et les animaux. [Study of the speed of
degradation of phosalone in soil, plants and animals.] Pages
220-221, _In Proceedings of the 13th International Congress of
Entomology; Aug 2-9, 1968, Moscow, USSR. Vol. 2. Edited by
G.Y. Bei-Benko.
005016977 Desmoras, J.; Fournel, J.; Koenig, F.H.; Metivier, J. (1964) Etude
au laboratoire et en serre d'un nouvel ester phosphorique: la
phosalone ou 11.974 R.P. [Laboratory and greenhouse
investigation of a new phosphoric ester: phosalone or 11,974
R.P.] Phytiatrie-Phytopharmacie 13(1):33-43.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006706 Desmoras, J.; Laurent, M. (1968) Phosalone and Oxygen Analog (12244
R.P.): Residues in Apples, Pears and Grapes: R.P.—
D.S.Ph. No. 12774. (Unpublished study received Jun 14, 1968
under 8F0668; prepared by Societe des Usines Chimiques Rhone-
Poulenc, submitted by Chipman Chemical Co., Inc., Burlingame,
Calif.; CDL:091171-H)
000006707 Desmoras, J.; Laurent, M.; Aublet, ?; Sasmayoux, ?; Savary, ?
(1968) Phosalone: Determination of Phosalone, 12244 R.P. and
20650 R.P. in Fruit from the U.S.A.: R.P.—D.S.Ph./D.S.An.Nord
No. 12850. (Unpublished study received Jun 14, 1968 under
8F0668; prepared by Societe des Usines Chimiques Rhone-Poulenc,
submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
CDL:091171-1)
000006648 Desmoras, J.; Laurent, M.; Aublet, J.C.; Savary, M. (1964) Insecti-
cides: Metabolism of Residues of 11974 R.P. in Plants (Sunflow-
er, Apple Tree, Pear Tree, Cherry Tree) Sprayed in Practical
Conditions. R.P.—D.S.Ph./D.R.An. 9511. (English trans-
lation; unpublished study received 1965 under 359-EX-46; pre-
pared by Societe des Usines Chiraiques Rhone-Poulenc, submitted
by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:123396-1)
005010413 Desmoras, J.; Laurent, M.; Buys, M. (1973) Phosalone. Pages
385-397, In Thin-layer and Liquid Chromatography and Analyses
of Pesticides of International Importance. Edited by J. Sherma
and G. Zweig. New York: Academic Press. (Analytical methods
for pesticides and plant growth regulators, vol. 7)
000006385 Desmoras, J,; Laurent, M.; Metivier, J.; Sauli, M.; Terlain, B.
(1966) Phosalone: Study on the Degradationof Phosalone (1974
R.P.) in Soil: R.P.—D.S.Ph. No. 11423, (Unpublished study
received Feb 2, 1967 under 7G0575; prepared by Societe des Usines
Chimiques Phone-Poulene, submitted by Chimpan Chemical Co., Inc.,
Burlingame, Calif.; CDL:090727-D)
000006386 Desmoras, J.; Laurent, M.; Terlain, B.; Aublet, J.C.; Sasmayoux,
J.C.; Savary, M. (1966) Study of the Metabolism of Phosalone
(11974 R.P.) in Plants: R.P.—D.S.Ph. No. 11686. (Unpublished
study received Feb 2, 1967 under 7G0575; prepared by Societe des
Usines Chimiques Rhone-Poulenc, submitted by Chipman Chemical
Co., Inc., Burlingame, Calif.; CDL:090727-E)
000006647 Desmoras, J.; Savary, M. (1964) A Bioassay Method for Residue Anal-
ysis of 11974 R.P.: R.P.—D.S.Ph. No. 9486. Includes method
dated Sep 18, 1963. (English translation; unpublished study re-
ceived 1965 under 359-EX-46; prepared by Societe des Usines Chi-
miques Rhone-Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:123396-H)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY '
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006702 Desmoras, J.; Terlain, B.; Savary, M. (1968) Phosalone: Identifi-
cation of Phosalone in Fruit Extracts: R.P.—D.S.Ph./
D.S.An.Nord No. 12849. Method dated May 8, 1968. (Unpublished
study received Jun 14, 1968 under 8F0668; prepared by Societe
des Usines Chimiques Rhone-Poulenc, submitted by Chipman Chemi-
cal Co., Inc., Burlingame, Calif.; CDL:091171-C)
005013769 Dolidze, G.V. (1969) Pestitsidebis shepaseba pitotoksikurobis
raodenobrivi da tvisobrivi machveneblebit. [Evaluation of
pesticides by quantitative and qualitative phytotoxicity
indicators.] Soobshcheniya Akademii Nauk Gruzinskoi SSR.
54(3):725-728.
000006979 Dorough, H.W.; Randolph, N.M. (1967) Dissipation of Zolone insecti-
cide from treated alfalfa. Journal of Economic Entomology 60
(1):285-286. (Also In unpublished study received Mar 4, 1976
under 6F1753; submitted by Rhodia, Inc., Monmouth Junction,
N.J.; CDL:098088-X)
GS0027011 Drevenkar, V.; Frobe, Z.; Vasilic, Z.; Tkalcevic, B. (1979) The rat
of urinary excretion of phosalone residues in occupationally
exposed persons. Science of the Total Environment 13: 235-243.
005008870 Drevenkar, V.; Stipcevic, M.; Stengl, B.; Stefanac, Z. (1979) Gas
chromatographic determination of alkali metal O,0-diethyl
phosphorodithioate present in trace amounts. Mikrochimica Acta
I(5/6):385-394.
000006643 Dubost, P.; Fournel, J.; Ganter, P.; Julou, L.; Koenig, F.; Myon,
J.; Bradenbac, J.; Lemoine, F. (1964) Acute Toxicity, Local
Tolerance, Anticholinesterase Activity and Chronic Toxicity in
Rats and Dogs: R.P.—D.S.Ph. 9203. (English translation;
unpublished study received 1965 under 359-EX-46; prepared by
Societe des Usines Chimiques Rhone-Poulene, submitted by Rhone-
Poulenc, Inc., Monmouth Junction, N.J.; CDL:123396-D)
005016593 Dzhashi, V.S.; Bakanidze, M.S. (1975) Materialy o vliyanii
rabochikh emul'sii fozalona i karbofosa razlichnykh
kontsentratsii na intensivnost' dykhaniya, aktivnost1 fermenta
katalazy i na nakoplenie sakharov v mandarinovykh list'yakh.
000008920 E.I. du Pont de Nemours and Company (1976) Data Supporting the Use
of Lannate (R) Methomyl Insecticide and Lannate (R) L Methomyl
Insecticide on Pecans. Summary of studies 095289-D through
095289-S. (Unpublished study received Sep 21, 1976 under 352-
342; CDL:095289-C)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005019632 Ebing, W. (1973) Probleme der Rueckstandsanalytik von Bioziden aus
der Sicht des Umweltschutzes. [Problems of biocide residue
analysis as seen from the viewpoint of environmental
protection.] Deutsche Lebensmittel-Rundschau 69(1):39-45.
005015711 Eckenrode, C.J.; Robbins, P.S.; Webb, D.R. (1975) 1974 Insecticide
Research Report on Cabbage Maggot, Seedcorn Maggot, Aphids on
Lettuce, and Phytotoxicity in Cucumbers. Geneva, N.Y.: New
York State Agricultural Experiment Station. (New York State
Agricultural Experiment Station, plant sciences: entomology
(Geneva), no. 9; New York's food and life sciences bulletin no.
56)
005009880 El-Sayed, M.M.; El-Dorry, H.F.A. (1971) Residues of some
organo-phosphorus insecticides on squash fruits. Bulletin of
the Entomological Society of Egypt, Economic Series V:95-99.
005016098 Esser, H.O. (1971) Terminal residues of organophosphorus
insecticides in animals. Pages 33-56, In Pesticide Terminal
Residues: Invited Papers from the International Symposium on
Pesticide Terminal Residues; Feb 17-19, 1971, Tel Aviv, Israel.
Edited by A.S. Tahori. London: Butterworths.
005011350 Evdokimov, P.O.; Nekrasova, M.A. (1971) Materialy po toksikologii
fozalona. [Data on toxicity of phosalone.] Sbornik Rabot,
Leningradskii Veterinarnyi Institut. [Collection of Works,
Leningrad Veterinary Institute.] (32):204-210.
005013968 FAO Panel of Experts on Pesticide Residues and the Environment
(1977) Pesticide Residues in Food. Report of the 1976 Joint
Meeting of the FAO Panel of Experts on Pesticide Residues and
the Environment and the WHO Expert Group on Pesticide Residues.
Geneva, Switzerland: World Health Organization. (WHO technical
series no. 612; FAO Food and Nutrition series no. 9; FAO Plant
Production and Protection series no. 8)
005010210 FAO Working Party of Experts on Pesticide Residues (1976)
Pesticide Residues in Food: Report of the 1975 Joint Meeting of
the FAO Working Party of Experts on Pesticide Residues and the
WHO Expert Committee on Pesticide Residues. Geneva,
Switzerland: World Health Organization. (WHO technical report
series no. 592; FAO plant production and protection series no.
1)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005008484 FAO Working Party of Experts on Pesticide Residues (1976)
Pesticide Residues in Food: Report of the 1975 Joint Meeting of
the FAO Working Party of Experts on Pesticide Residues and the
WHO Expert Committee on Pesticide Residues. Rome, Italy: Food
and Agriculture Organization of the United Nations. (FAO plant
production and protection series no. 1; WHO technical report
series no. 592)
005013445 FAO Working Party of Experts on Pesticide Residues (1976) 1975
Evaluations of Some Pesticide Residues in Food. By the FAO
Working Party of Experts on Pesticide Residues and the WHO
Expert Committee on Pesticide Residues. Geneva, Switzerland:
World Health Organization. (WHO pesticide residues series no.
5)
005010961 FAO Working Party of Experts on Pesticide Residues (1976) 1975
Evaluations of Some Pesticide Residues in Food: The Monographs.
By the Joint Meeting of the FAO Working Party of Experts on
Pesticide Residues and the WHO Expert Committee on Pesticide
Residues. Geneva, Switzerland: World Health Organization.
(WHO technical report series no. 592; FAO plant production and
protection series no. 1; WHO pesticide residue series no. 5)
005007742 Farhat, S.; Baig, M.M.H. (1977) A note on the infrared
spectrophotometric assay of phosalone alone or in combination
with DDT. Pakistan Journal of Scientific and Industrial
Research 20(1):15-17.
005012643 Fateeva, O.F.; Popova, V.A. (1978) Khromato-enzymnyy metod
razdel'nogo opredeleniya fozalona i ego metabolitov v plodakh i
list'yakh yabloni. [Chromato-enzymatic determination of
phosalone and its metabolites in apple fruits and leaves.]
Khimiya v Sel'skom Khozyaistve. [Chemistry in Agriculture.]
16(l):64-67.
005015526 Ferhat, S.; Baig, M.M.H. (1974) Infra red spectrophotometric
method of analysis of phosalone and its DDT mixture. Pages
56-56, _In Proceedings of the Pakistan Science Conference. Vol.
25, No.~3. Lahore, Pakistan: Pakistan Association for the
Advancement of Science.
005013738 Fischer, R.; Plazer-Altenburg, D. (1969) Nachweis von
Phosphor-Insecticiden in biologischen Material: IV.
Mitteilung. [Identification of organophosphate insecticides in
biological material: part IV.] Archives of Toxicology
25(2):216-222.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005017631 Floru, S.; Goga, E.; Tucaliuc, M.; Suta, V.; Isac, M. (1977)
Reziduuri de pesticide in urma tratamentelor in pomicultura in
conditii de productie. [Pesticide residues after the
application of treatments in commercial orchards.] Analele
Institutului de Cercetari pentru Protectia Plantelor, Academia
de Stiinte Agricole si Silvice. [Annals of the Research
Institute for Plant Protection, Academy of Agricultural and
Forestry Sciences.] XII:425-435.
005015767 Food and Agriculture Organization of the United Nations,
Legislative Service (1970) Canada. Current Food Additives
Legislation (135):3-5.
000006693 Ford, R.T.G.; Terry, H.J. (1965) Phosalone: An Experiment on the
Tolerance of Pheasant Chicks to Field Sprays. (Unpublished
study received Dec 15, 1966 under 7G0575; prepared by May &
Baker, Ltd., submitted by Chipman Chemical Co., Inc., Bur-
lingame, Calif.; CDL:090729-H)
005012942 Forsythe, H.Y., Jr.; Hall, F.R. (1972) Control of the plum
curculio in Ohio. Journal of Economic Entomology
65(6):1703-1706.
000006399 Fournel, J. (1966) Phosalone: Evaluation of the Choiinesterase
Activity of the Staff Employed in the Manufacture and Experimen-
tation of Phosalone (R.P. 11974). (Unpublished study received
Feb 2, 1967 under 7G0575; prepared by Societe des Usines Chi-
miques Rhone-Poulenc, submitted by Chipman Chemical Co., Inc.,
Burlingame, Calif.; CDL:090727-T)
005010958 Franz, J.M.; Hassan, S.A.; Bogenschuetz, H. (1976) Einige
Ergebnisse bei der standardisierten Laboratoriumspruefung der
Auswirkungen von Pflanzenschutzmitteln auf entomophage
Nutzarthropoden. [Some results of standardized laboratory
tests on the effect of pesticides on entomophagous beneficial
arthropods.] Nachrichtenblatt des Deutschen
Pflanzenschutzdienstes (Braunschweig) 28(12):181-183.
005005239 Freed, V.H.; Schmedding, D.; Kohnert, R.; Haque, R. (1979)
Physical chemical properties of several organophosphates: some
implication in environmental and biological behavior.
Pesticide Biochemistry and Physiology 10(2):203-211.
005016097 Frehse, H. (1971) Terminal residues of organophosphorus
insecticides in plants. Pages 9-32, In Pesticide Terminal
Residues: Invited Papers from the International Symposium on
Pesticide Terminal Residues; Feb 17-19, 1971, Tel Aviv, Israel.
Edited by A.S. Tahori. London: Butterworths.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005015911 Frolov, B.A.; Kachekova, S.; Stepushin, A.E.; Bulatov, R.M.;
Furygin, E.A. (1976) Insektitsid benzofosfat kak sredstvo
bor'by s klopom Cimex lectularius L. v ptichnikakh. [Use of
insecticide benzophosphate for control of bug Cimex
Sanitarii 52:175-178.
005008442 Gallo, M.A. (1975) Studies on the toxicity of phosalone [abstract
no. 55]. Toxicology and Applied Pharmacology 33(1):144.
005018186 Gallo, M.A.; Wang, D.I., inventors; Rhodia, Inc., assignee (1977)
Synergistic pesticidal mixtures of phosalone and malathion and
process for controlling arthropods therewith. U.S. patent
4,064,237. Dec 20. 8 p. Int. Cl. 424/200.
005008921 Gauer, W.O.; Seiber, J.N. (1971) Analysis of Zolone
insecticide-acaricide on grapes. Bulletin of Environmental
Contamination and Toxicology 6(2):183-188.
005014814 Gergaya, M.S.; Bezhanidze, A.A. (1977) Dinamika razlozheniya
pestitsidov v zelenykh list'yakh chaya. [The rate of pesticide
breakdown in green tea leaves.] Khimiya v Sel'skom
Khozyaistve. [Chemistry in Agriculture.] 15(3):75-77.
005016976 Gerig, L. (1974) Bienen und geplante Maikaeferbekaempfung im Kt.
Thurgau 1973. [Bees and organized cockchafer control in
Thurgau Canton 1973.] Schweizerische Bienen-Zeitung
97(6):256-264.
005019860 Gladenko, I.N.; Alekseenko, P.M.; Yaroshenko, V.I. (1973)
Opasnost1 dlya pchel nekotorykh fosfororganicheskikh
yadokhimikatov. [The danger to bees of certain
organophosphorus toxic chemicals.] Veterinariya (Moscow).
005011367 Glukhova, L.G.; Vasilenko, T.E.; Apon, N.I. (1978) Sravnitel'naya
kharakteristika vliyaniya khlor- i fosfororganicheskikh
yadokhimikatov na zhelcheobrazovatel'nuyu funktsiyu pecheni.
and organophosphorus pesticides on the biligenic function of
the liver.] Vrachebnoe Delo. [Medical Profession.]
(11):130-131.
005013287 Grebenshchikova, V.M. (1977) Sokrashchennye skhemy obrabotok
protiv yablonnoi plodozhorki. [Shortened methods of treatment
against the codling moth.] Vestnik Sel'skokhozyaistvennoi
Nauki Kazakhstana. [Journal of Agricultural Science of
Kazakhstan.] 20(5):57-59.
005012134 Greenstone, E.S. (1975) Farmworkers in jeopardy: OSHA, EPA, and
the pesticide hazard. Ecology Law Quarterly 5(1):69-137.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005020112 Grishchenko, L.I.; Verkhovskii, A.P.; Trondina, G.A. (1975)
Toksichnost1 benzofosfata (fozalona) dlia ryb i diagnostika
otravlenii. [Toxicity of benzophosphate (phosalone) for fish
and diagnosis of poisonings.] Byulleten Vsesoyuznogo Instituta
Eksperimental'noi Veterinarii. [Bulletin of the Ail-Union
Institute of Experimental Veterinary Medicine.] (20):58-61.
000006400 Guardigli, A. (19??) Laboratory Comments: Field Test Project
No. PAS 66-80—Cotton—RP-11974—Dumas, Arkansas. (Unpublished
study received Mar 6, 1967 under 7G0575; prepared by Rhodia,
Inc., submitted by Chipman Chemical Co., Inc., Burlingame,
Calif.; CDL:092863-A)
000006389 Guardigli, A. (1964) Laboratory Analytical Data Sheet for Residues
of R.P. 11974: [Phosalone]. (Unpublished study received Feb 2,
1967 under 7G0575; prepared by Rhodia, Inc., submitted by Chip-
man Chemical Co., Inc., Burlingame, Calif.; CDL:090727-H)
000006769 Guardigli, A. (1964) Laboratory Analytical Data Sheet for Residues:
Field Test Project No. BB 64-26. (Unpublished study received
Feb 2, 1967 under 7G0575; prepared by Rhodia, Inc., submitted
by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090727-L)
000006388 Guardigli, A. (1965) Residue Summary Sheet: [Phosalone]. (Unpub-
lished study including project nos. BB 10-64-12, BB 12-64-20,
BB 64-26, BB 65-18, BB 65-27, BB 65-47, BB 65-49, BB 65-127,
C 64-12, C 65-17, C 65-30 and Port 65-47, received Feb 2, 1967
under 7G0575; prepared by Rhodia, Inc., submitted by Chipman
Chemical Co., Inc., Burlingame, Calif.; CDL:090727-G)
000006680 Guardigli, A. (1966) Comparison of Residues of Phosalone in Alfalfa
Samples: Project Nos. BB 66-79 and C 66-22. (Unpublished study
received Jun 14, 1968 under 8F0668; prepared by Rhodia, Inc.,
submitted by Chipman Chemical Co., Inc., Burlingame, Calif.;
CDL:091170-1)
000006391 Guardigli, A. (1966) Laboratory Analytical Data Sheet for Residues:
Field Test Project No. BB 66-126. (Unpublished study received
Feb 2, 1967 under 7G0575; prepared by Rhodia, Inc., submitted by
Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090727-J)
000006714 Guardigli, A. (1966) Laboratory Raw Analytical Data. (Unpublished
study including letter dated Feb 9, 1965 from L. Farber to L.
Reed and test nos. BB-64-26, BB-65-125, C-64-12, C-65-27, Port-
65-66 and Port 66-12, received Jun 14, 1968 under 8F0668; pre-
pared by Rhodia, Inc., submitted by Chipman Chemical Co., Inc.,
Burlingame, Calif.; CDL:091171-AD)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006392 Guardigli, A. (1966) Residue Summary Sheet: [Phosalone]. (Unpub-
lished study including project nos. BB 64-26, BB 65-125, C 64-
12, C 65-27, Port 65-66 and Port 66-12, received Feb 2, 1967
under 7G0575; prepared by Rhodia, Inc., submitted by Chipman
Chemical Co., Inc., Burlingame, Calif.; CDL:090727-K)
000006390 Guardigli, A. (1966) Residue Summary Sheet: [Phosalone]. (Unpub-
lished study including project nos. C-64-12 and BB-65-63, re-
ceived Feb 2, 1967 under 7G0575; prepared by Rhodia, Inc., sub-
mitted by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:
090727-1)
000006395 Guardigli, A. (1966) Residue Summary Sheet: [Phosalone]. (Unpub-
lished study including project nos. C 64-16, C 65-44, BB 65-42
and BB 65-51, received Feb 2, 1967 under 7G0575; prepared by
Rhodia, Inc., submitted by Chipman Chemical Co., Inc., Burlin-
game, Calif.; CDL.-090727-O)
000006070 Guardigli, A. (1967) Analytical Procedure for Phosalone Residue
Determination in Milk and Animal Tissues by Electron Capture
Chromatography. Method No. 54-C dated Aug 14, 1967. (Unpub-
lished study received Sep 12, 1968 under 9F0759; submitted by
Rhodia, Inc., New Brunswick, N.J.; CDL:093071-D)
000006681 Guardigli, A. (1967) Laboratory Analytical Data Sheet for Residues:
Field Test Project No. SR 64-300. (Unpublished study including
letter dated Feb 1, 1965 from L. Farber to L. Reed and field
test project nos. PA 66-47, PAS 65-39, PAS 65-40; PAS 65-49, PAS
66-80 and PAS 66-92, received Jun 14, 1968 under 8F0668; pre-
pared by Rhodia, Inc., submitted by Chipman Chemical Co., Inc.,
Burlingame, Calif.; CDL:091170-J)
000006713 Guardigli, A. (1967) Laboratory Raw Analytical Data. (Unpublished
study including letter dated Mar 2, 1965 from L. Farber to L.
Reed and field test project nos. BB-65-63, BB-67-100, C 64-12,
and PA 67-28, received Jun 14, 1968 under 8F0668; prepared by
Rhodia, Inc., submitted by Chipman Chemical Co., Inc.,
Burlingame, Calif.; CDL:091171-Z)
000006174 Guardigli, A. (1967) Phosalone (RP 11974) (Zolone)—Recovery from
Acid Delinted Cotton Seed. (Unpublished study received Oct 18,
1967 under unknown admin, no.; prepared by Chipman Chemical Co.,
Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.;
CDL:123376-A)
000006393 Guardigli, A. (1967) Residue Summary Sheet: [Phosalone]. (Unpub-
lished study including project nos. SR 64-300, PAS 65-39, PAS
65-40, PAS 65-49, PAS 66-47, PAS 66-80 and PA 66-92, received
Feb 2, 1967 under 7G0575; prepared by Rhodia, Inc., submitted
by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090727-M)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
OC0006394 Guardigli, A. (1967) Residue Summary Sheet: Field Test Project
No. Port 66-11. (Unpublished study received Feb 2, 1967 under
7G0575; prepared by Rhodia, Inc., submitted by Chipman Chemical
Co., Inc., Burlingame, Calif.; CDL:090727-N)
000006711 Guardigli, A. (1968) Results of Tests on the Amount of Residue Re-
maining. (Unpublished study including letters dated Dec 9,
1964, Jan 21, 1965 and Oct 1, 1965 from L. Farber to L. Reed
and field test nos. BB-10-64-12, BB-64-10, BB-64-26, BB-65-47,
BB-65-49, BB-65-127, C-64-12, C-65-17; C-65-30, C-66-32,
C-66-33, PA-66-32, PA-67-58 and Port-65-47, received Jun 14,
1968 under 8F0668; prepared by Rhodia, Inc., submitted by Chip-
man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-N)
000006575 Guardigli, A. (1972) Leaching Studies on Phosalone: Laboratory Ex-
periments. (Unpublished study received May 25, 1973 under
3F1337; submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:
093575-C)
000006068 Guardigli, A. (1972) Phosalone Transfer in Fruits Processing:
Possible Residue in Raw Apple Juice and Dry Apple Pomace: Labo-
ratory Experiments. (Unpublished study received Feb 16, 1972
under 2H5013; submitted by Rhodia, Inc., New Brunswick, N.J.;
CDL:221747-C)
000006971 Guardigli, A. (1973) Residue Studies in the Milk and Tissues of
Dairy Cows Fed Phosalone. (Unpublished study received Mar 4,
1976 under 6F1753; submitted by Rhodia, Inc., Monmouth Junction,
N.J.; CDL:098088-L)
000006994 Guardigli, A. (1974) Residue Studies in Tissues and Eggs of Bob-
white Quail Fed Phosalone. (Unpublished study received Mar 4,
1976 under 6F1753; prepared in cooperation with Bio/dynamics,
Inc., submitted by Rhodia, Inc., Monmouth Junction, N.J.; CDL:
098088-T)
000006495 Guardigli, A. (1974) Residue Studies in Tissues and Eggs of Bob-
white Quail Fed Phosalone. (Unpublished study received Jun 13,
1974 under 359-620; prepared by Rhodia, Inc. in cooperation with
Bio-dynamics, Inc., submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:120351-W)
000006980 Guardigli, A. (1974) Residue Studies in Tissues and Eggs of Poultry
Fed Dietary Phosalone. (Unpublished study received Mar 4, 1976
under 6F1753; submitted by Rhodia, Inc., Monmouth Junction,
N.J.; CDL:098088-Y)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006970 Guardigli, A. (1975) Phosalone Oxygen Analog (Oxon) Residues in/on
Alfalfa. (Unpublished study including residue reports 111973-
053, 170473-055, 191573-004, 191573-028, 213673-024, 263174-003
and 263774-010, received Mar 4, 1976 under 6F1753; submitted by
Rhcdia, Inc., Monmouth Junction, N.J.; CDL:098088-K)
000006969 Guardigli, A. (1975) Phosalone Residues in/on Alfalfa. (Unpub-
lished study including residue reports 111973-053, 170473-055,
191573-004, 191573-028, 213673-024, 222173-045, 263174-003 and
263774-010, received Mar 4, 1976 under 6F1753; submitted by
Rhcdia, Inc., Monmouth Junction, N.J.; CDL:098088-J)
000006679 Guardigli, A.; Lienk, S.E. (1967) Laboratory Analytical Data Sheet
for Residues: Field Test Project No. BB 67-79. (Unpublished
study received Jun 14, 1968 under 8F0668; prepared by Rhcdia,
Inc., submitted by Chipman Chemical Co., Inc., Burlingame,
Calif.; CDL:091170-H)
000006783 Guardigli, A.; Martwinski, P. (1969) Phosalone Residues on Apples
Treated with Zolone 25% Wettable Powder at Several Application
Rates. (Unpublished study including field test project nos. AT
69.16-AT 69.17, BB 68-66, BB 69.7-BB 69.9, Port 68-12 and Port
69-56, received Dec 22, 1969 under 359-626; prepared by Rhcdia,
Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.;
CDL:003174-W)
000006358 Guardigli, A.; Martwinski, P. (1970) Results of Almond Residue
Tests: Part D. (Unpublished study including field test project
nos. PAW 69-5, PAW 69-6, PAW 69-9, PAW 69-13, PAW 69-18 and
PAW 68-18, received Jun 26, 1972 under OF0983; submitted by
Rhcdia, Inc., New Brunswick, N.J.; CDL:091691-J)
000006511 Guardigli, A.; Martwinski, P. (1970) Results of Residue Tests.
(Unpublished study including report nos. AT 69-14, AT 69-20, AT
69-22, AT 69-47, PA 67-45, PA 68-50, PA 69-29, PAS 67-77, PAW
69-2 and PAW 69-7, received Mar 12, 1970 under OF0948; submitted
by Rhcdia, Inc., New Brunswick, N.J.; CDL:091617-B)
000006480 Guardigli, A.; Martwinski, P. (1971) Residue Data: [Zolone]. (Un-
published study including field test project nos. BB 65-63, BB
68-91, PA 68-46, PA 70-25/25A, PA 70-26, PA 70-27/27A and PAW
70-29, received Nov 18, 1971 under 359-626; prepared by Rhodia,
Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.;
CDL:003175-X)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006576 Guardigli, A.; Martwinski, P. (1972) Phosalone—Potato Petition:
Residue Summary—Potatoes. (Unpublished study including field
test project nos. AT 71-15, BB 68-87, BB 68-94, BB 69-60, C 66-
41, CH 71-61, CH 71-84, CH 71-103, FW 71-52 and Port 71-30,
received May 25, 1973 under 3F1337; submitted by Rhcdia, Inc.,
New Brunswick, N.J.; CDL:093575-E)
000006086 Guillot, ?; Kauffmann, ? (1968) Insecticides: Phosalone: Flavor
Study in Apples: R.P.—C.E. Ag Emerainville No. 362. (Unpub-
lished study received Aug 19, 1971 under 2F1193; prepared by
Rhone-Poulenc, submitted by Rhodia, Inc., New Brunswick, N.J.;
CDL:093518-B)
005015531 Gusein-Adzhiev, Z.K.; Kan, P.T. (1976) Toksichnost1 benzofosfata
dlya krupnogo pogatogo skota i ovets pri naruzbnom primenenii.
external application.] Trudy, Vsesoyuznyi
Nauchno-Issledovatel'skii Institut Veterinarnoi Sanitarii.
Veterinary Sanitation.] 52:135-141.
005013768 Gusein-Adzhiev, Z.K.; Leshchev, V.V. (1976) 0 bydelyenii
benzofosfata v moloko pri obrabotke korov protiv iksodovykh
kleshchei. [The excretion of benzophosphate into milk by cows
treated against ixodes ticks.] Trudy, Vsesoyuznyi
Nauchno-Issledovatel'skii Institut Veterinarnoi Sanitarii.
Veterinary Sanitation.] 52:149-151.
005005527 Hassan, S.A. (1977) Standardized techniques for testing
side-effects of pesticides on beneficial arthropods in the
laboratory. Zeitschrift fuer Pflanzenkrankheiten und
Pflanzenschutz. [Journal of Plant Diseases and Protection.]
84(3):158-163.
GS0027017 Hastings, S.F. (1977) Acute Oral LD™ in Mallard Ducks with
Phosalone Technical. Project No. CH-68. Report No. SEH 77:9.
(Unpublished study received Dec, 1980 under 6F1753; prepared by
Rhodia, Inc., Hess and Clark Division, Submitted by Rhodia, Inc.)
000006964 Henckler, P. (1973) Project Number 170473-008. (Unpublished study
including letter dated Nov 6, 1973 from D.I. Wang to C.C. Comp-
ton, received Oct 18, 1973 under 3E1401; prepared by Rhodia,
Inc., submitted by Interregional Research Project No. 4, New
Brunswick, N.J.; CDL:098195-A)
000006107 Henckler, P. (1973) Specific Analytical Method for Technical Phosa-
lone and Its Formulations: Liquid and Wettable Powders. Method
no. 124 dated Nov 1973. (Unpublished study received Mar 4, 1976
under 6F1753; submitted by Rhodia, Inc., Monmouth Junction,
N.J.; CDL:095979-D)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006483 Henckler, P.M.; Dennis, S. (1973) Residue Summary: Apricots. (Un-
published study including residue final report nos. 170473-042
and 170473-053, received Mar 29, 1974 under 359-620; prepared by
Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, N.J.; CDL:028124-C)
000006484 Henckler, P.M.; Dennis, S.; Collins, R. (1973) Residue Summary:
Cherries. (Unpublished study including residue final report
nos. 170473-041 (A), 170473-041 (B) and 213673-013, received Mar
29, 1974 under 359-620; prepared by Rhodia, Inc., submitted by
Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:028124-D)
000006124 Henckler, P.M.; Reed, J.P. (1974) Zolone—Carrot: Residue Final Re-
port No. 112973-133. (Unpublished study received Feb 12, 1974
under 4E1468; prepared in cooperation with Rutgers Univ., Dept.
of Entomology, submitted by Interregional Research Project
No. 4, New Brunswick, N.J.; CDL:093909-A)
000006485 Henckler, P.M.; Rice, R. (1973) Residue Summary: Nectarines: Pro-
ject No. 180473-032. (Unpublished study received Mar 29, 1974
under 359-620; prepared by Rhodia, Inc. in cooperation with
Univ. of California, submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:028124-E)
000006487 Henckler, P.M.; Rice, R. (1973) Residue Summary: Plums: Project
No. 180473-033. (Unpublished study received Mar 29, 1974 under
359-620; prepared by Rhodia, Inc. in cooperation with Univ. of
California, submitted by Rhone-Poulenc, Inc., Monmouth Junction,
N.J.; CDL:028124-G)
000006486 Henckler, P.M.; Taylor, J.C.; Corner, G.; Dennis, S. (1973) Residue
Summary: Peaches. (Unpublished study including residue final
report nos. ARK 72-77, 123973-023 and 170473-072, received Mar
29, 1974 under 359-620; prepared by Rhodia, Inc. in cooperation
with Louisiana State Univ. and Clemson Univ., submitted by
Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:028124-F)
005009331 Hislop, R.G.; Acker, C.; Prokopy, R.J. (1977) Influence of
pesticides on predacious and phytophagous mite populations in
Massachusetts apple orchards. Journal of the New York
Entomological Society 85(4):180.
005015532 Husein, F.; Gouhar, K.A.; Guirguis, M.W. (1975) Effect of certain
organophosphorus insecticides on fruit quality of Valencia
orange. Annals of Agricultural Science, Moshtohor 3:163-171.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005017964 Iren, Z. (1972) Baglarda ciceklenme devresinde kullanilan bazi
ilaclarin orta anadolu bolgesinde dollenmeye olan etkilerinin
arastirilmasi. [Investigation into the effects of certain
chemicals on fertilization of vines in blosson time in central
Anatolia.] Pages 44-45, _In Zirai Mucadele Arastirma Yilligi.
Zirai Mucadele Arastirma Enstitusu.
005006342 Ishitani, A.; Yukimoto, M.; Yoshida, K. (1975) Nogaku no
kakushusakubutsu ni taisuru yakugai ni tsuite: II. Yuki rinkei
satchuzai. [Phytotoxicities of agricultural chemicals to
crops: II. Organophosphorus insecticides.] Noyaku Kensasho
Hokoku. [Bulletin of the Agricultural Chemicals Inspection
Station.] (15):92-97.
005016273 Ivanova, L.N.; Molozhanova, E.G. (1974) 0 kinetike prevrashcheniya
nekotorykh pestitsidov v pochve. [The transformation kinetics
of certain pesticides in soil.] Khimiya v Sel'skom
Khozyaistve. [Chemistry in Agriculture.] 12(5):363-365.
005014687 Ivanova, L.N.; Russu-Lupan, I.T.; Belaya, L.L.; Fedorchenko, V.S.;
Mamusevich, T.I. (1975) 0 verifikatsii prognoza dinamiki
pestitsidov v produktahk rastenievodstva. [On verification of
prognosis on the dynamics of pesticides in products of plant
cultivation.] Gigiena i Sanitariya. [Hygiene and Sanitation.]
40(6):105-107.
005010956 Jenik, M.; Madaric, A.; Gecova, K. (1975) Stanovenie
organofosforovych insekticidov v ovzdusi. [The determination
of organophosphorus insecticides in the atmosphere.]
Ceskoslovenska Hygiena. [Czechoslovak Hygiene.] 20(2):83-89.
005013290 Kachekova, S.; Frolov, B.A.; Riazhenov, N.I. (1975) Dinamika
ostatkov benzofosfata v organakh i tkaniakh obrabotannykh kur.
treated chickens.] Trudy, Vsesoyuznyi
Nauchno-Issledovatel'skii Institut Veterinarnoi Sanitarii.
Veterinary Sanitation.] 51:96-99.
005010804 Kagan, Y.S.; Vojtenko, G.A.; Svetlij, S.S.; Zlatjev, Z. (1975) A
method for the quantitative evaluation of combined and complex
pesticide effects on organisms. Pages 631-635, _In Pesticides:
International Union of Pure and Applied Chemistry Third
International Congress; Jul 3-9, 1974, Helsinki, Finland.
Edited by F. Coulston and F. Korte. Stuttgart, West Germany:
George Thieme. (Environmental quality and safety supplement,
vol. Ill)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005015385 Kamil'dzhanov, A.K. (1970) Zagryaznenie atmosfernogo vozdukha
fozalonom pri primenenii ego v sel'skom khozyaystve v
usloviyakh Uzbekistana. [Contamination of the atmosphere with
phosalone during its agricultural use in Uzbekistan.]
Meditsinskii Zhurnal Uzbekistana. [Medical Journal of
Uzbekistan.] (10):122-123.
005013291 Kamil'dzhanov, A.K. (1975) Srednesutochnaia predel'no dopustimaia
kontsentratsiia fozalona v atmosfernom vozdukhe. [Average
daily maximum permissible concentration of phosalone in the
atmosphere.] Meditsinskii Zhurnal Uzbekistana. [Medical
Journal of Uzbekistan.] (10):53-56.
005015130 Kamil'dzhanov, A.K.; Khasanov, Y.U. (1971) Ob ostatochnykh
kolichestvakh fozalona v obrabotannykh im yablokakh i
lyutserne. [Phosalone residues in treated apples and alfalfa.]
Gigiena i Sanitariya. [Hygiene and Sanitation.] 36(6):104-105.
005017832 Kanarev, G.; Mateeva, A. (1975) Vliyanir na nyakoi pestitsidi
v'rkhu koprinenata buba. [Effect of some pesticides on
silkworms.] Priroda (Sofia). [Nature.] 24(2):65-66.
005009436 Kapitan, A.I.; Sukhoruchenko, G.I.; Tolstova, Y.S. (1972)
Toksichnost' pestitisidov dlya zlatoglazki. [Toxicity of
pesticides for aphid lions.] Zashchita Rastenii (Moscow).
005016277 Karadzhov, S. (1973) Dinamika na rastitelnoyadnite i khishtnite
akari pri biologichna sistema za borba s nepriyatelite po
yabulkata. [Dynamics of the phytophagous and predacious mites
in a biological system of pest control of apple.] Gradinarska
i Lozarska Nauka. [Horticultural and Viticultural Sciences.]
X(5):51-62.
005008877 Kawamura, Y.; Takeda, M.; Uchiyama, M. (1978) Studies on analysis
of pesticide residues in foods (XXVIII): Determination of 33
organophosphorus pesticides in agricultural crops. Journal of
Food Hygienic Society of Japan 19(6):518-523.
005013292 Khalpaev, O.S.; Akhmedzhanov, K.A. (1973) Tsitokhimicheskie i
drugie pokazateli perifericheskoi krovi pri ostrykh
otravleniiakh fozalonom v eksperimente. [Cytochemical and
other indices of peripheral blood during experimental acute
poisoning with phosalone.] Meditsinskii Zhurnal Uzbekistana.
005014953 Khan, S.A.; Shafique, R.M.; Kahn, B.A. (1973) Phytotoxicity caused
by pesticides in Brassica. Journal of Agricultural Research
(Lahore) 11(1):55-68.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005013534
005016710
005016365
005016275
005014545
005011360
005014888
000006966
005015138
Khasanov, Y.U. (1974) Vliianie nekotorykh pestitsidov i
mineral 'nykh udobrenii na sintez vitaminov v
ovoshche-bakchevykh i fruktovykh kul'turakh. [Effect of some
pesticides and mineral fertilizers on synthesis of vitamins in
cucurbitaceous vegetable and fruit cultures.] Meditsinskii
Zhurnal Uzbekistana. [Medical Journal of Uzbekistan.]
Khasanov, Y.U. ; Rasulev, B.D. (1970) Ostatochnyye kolichestva
antio, rogora, fozalona i DDT v yablokakh i lyutserne.
apples and alfalfa.] Meditsinskii Zhurnal Uzbekistana.
Khukhrii, O.V. (1974) Diya insektytsydiv na Aphid ius ervi Hal.,
parazita horokhovoyi popelytsi ( Acyrthos iphon pisum Harr.).
of the pea aphid ( Acyrthos iphon pisum Harr.).] Zashchita
Rastenii (Kiev). [Plant Protection.] (20):25-27.
Khushcha, V.L. (1978) Fitotoksychnist ' pestytsydiv pry
ul ' tramaloob ' yemnomu obpryskuvanni u sadakh. [Phytotoxicity of
pesticides following ultralow volume spraying in orchards.]
Visnik Sil's'kogospodars'koi Nauki. [Journal of Agricultural
Science.] (1): 28-30.
Kiguradze, K.T. ; Ordzhonikidze, E.K. (1977) Pospororganuli
insektitsidebis gavlena mtsenaris zrda-ganvitarebasa da
nakopebis biokimiur machveneblebze . [The effect of
organophosphorus insecticides on the plant growth and
development of plants and the biochemical indicators of fruit.]
Soobshcheniya Akademii Nauk Gruzinskoi SSR. [Bulletin of the
Academy of Sciences of the Georgian SSR.] 86 (2): 461-464.
Kim, N.G. ; Guzeev, G.F.; Khalilov, S.K. (1977) Vliyanie
pestitsidov na entomofaunu orekhovoplodovykh lesov Srednei
Asii. [Effect of pesticides on entomofauna of nut-fruit tree
forests of Central Asia.] Khimiya v Sel'skom Khozyaistve.
Kisilenko, M.A. ; Pis'mennaya, M.V. (1973) Opredeleniye fozalona,
ftalofosa, fenkaptona, tsideala i sayfosa v vode.
and sayfos in water.] Metody Opredeleniya Pestitsidov v Vode.
(1): 27-32.
Kitching, U. , tr. (1975) On the Prognosis of Phosalone Residues in
Water Reservoirs: S.U.C.R.P.— D.S.Ph. No. 17733. (English
translation; unpublished study received Mar 4, 1976 under
6F1753; submitted by Phodia, Inc., Monmouth Junction, N. J. ; CDL:
098088-F)
Klisenko, M.A. ; Pis'mennaya, M.V. ; Novitskaya, L.P. ; Brodskaya,
N.M. (1968) Opredelenie ftalofosa i fozalona v vozdukhe.
Sanitariya. [Hygiene and Sanitation.] 32 (8): 67-70.
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
GS0027012 Knaak, J.B.; Maddy, K.T.; Gallo, M.A.; Lillie, D.T.; Craine, E.M.:
Serat, W.F. (1978) Worker reentry studiues involving phosalone
application to citrus groves. Toxicology and Applied
Pharmacology 46: 363-374.
GS0020713 Knaak, J.B.; Schlocker, P.; Ackerman, C.R.; Seiber, J.N. (1980)
Reentry research: Establishment of safe pesticide levels on
foliage. Bull. Environm. Contam. Toxicol. 24: 769-804.
000006088 Knobel, H. (1971) Final Report: District Project No. AT 71-32.
(Unpublished study received on unknown date under 2F1193; pre-
pared in cooperation with Coca Cola Co., submitted by Rhodia,
Inc., New Brunswick, N.J.; CDL:093518-E)
000006089 Knobel, H. (1971) Final Report: District Project No. AT 71-33.
(Unpublished study received on unknown date under 2F1193; pre-
pared in cooperation with Coca Cola Co., submitted by Rhodia,
Inc., New Brunswick, N.J.; CDL:093518-F)
000006538 Knobel, H.; Estes, P. (1968) Report No. AT 68-41. (Unpublished
study received Feb 16, 1970 under OF0948; prepared in coopera-
tion with Auburn Univ., submitted by Rhodia, Inc., New Bruns-
wick, N.J.; CDL:092026-U)
000006938 Knobel, H. ; Rock, G. (1969) Summary Report: District Project No. AT
69-16. (Unpublished study received Dec 22, 1969 under 359-626;
prepared in cooperation with North Carolina State Univ., Dept.
of Entomology, submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, N.J.; CDL:003174-R)
000006939 Knobel, H.; Rock, G. (1969) Summary Report: District Project No. AT
69-17. (Unpublished study received Dec 22, 1969 under 359-626;
prepared in cooperation with North Carolina State Univ., Dept.
of Entomology, submitted by Rhone-Poulenc, Inc., Monnouth Junc-
tion, N.J.; CDL:003174-S)
000014908 Koehler, C.S.; Jurich, R.; Frobase, J.; et al. (1978) Field Evalua-
tion Report on the Use of Orthene/Medicap Systemic Tree Injec-
tion Cartridges: FEP No. 1-73-10. (Unpublished study including
letter dated Feb 3, 1978 from J. O'Neal to Warren D. Wolfe and
FEP nos. 0-76-7, 0-76-8, 0-76-9..., received Mar 6, 1979 under
37979-1; submitted by Creative Sales, Inc., Fremont, Nebr.;
CDL:237989-B)
005014549 Kol'kovski, P.G.; Kavakova, Y.D. (1974) Ekspressivnyi metod
opredeleniia BI-58 i fosalona v vozdukhe. [Express method for
the determination of BI-58 and phosalone in the air.] Gigiena
i Sanitariya. [Hygiene and Sanitation.] 4:83-86.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005015136 Konyukhov, A.F- (1975) Metody obnaruzheniya fosfororganicheskikh
pestisidov v organakh i tkanyakh zhivotnykh, kormakh i vode.
organs and tissues of animals, in foodstuffs, and in water.]
Trudy Vsesoyunogo Instituta Eksperimental'noi Veterinarii.
Veterinary Science.] 43:346-358.
005014055 Konyukhov, A.F. (1975) Obnaruzhenie fosalona v patologicheskom
materiale. [Detection of phosalone in pathological specimens.]
Veterinariya (Moscow). [Veterinary Science.] (4):93-94.
005016360 Konyukhov, A.F. (1975) Opredelenie fozalona v kombikormakh. [The
determination of phosalone in mixed feeds.] Veterinariya
(Moscow). [Veterinary Science.] (l):84-85.
005015389 Konyukhov, A.F.; Poloz, D.D.; Kokhtyuk, F.P. (1975) Nakoplenie i
dlitel'nost' cokhraneniia fosalona v organakh kur pri ostrom
otravlenii. [Accumulation and persistance of phosalone in the
organs of chickens after acute poisoning.] Khimiya v Sel'skom
Khozyaistve. [Chemistry in Agriculture.] 13(6):459-460.
005014056 Korzhevenko, G.N.; Leshchev, V.V.; Metelev, V.V.; Brichko, V.F.
(1976) Uskorennyi metod diagnostiki otravlenii ryb
fosfororganichimi pestitsidami. [Rapid diagnosis of
organophosphorus pesticide poisoning in fish.] Veterinariya
(Moscow). [Veterinary Science.] (9):90-92.
005013446 Kosmatyi, E.S.; Tverskaya, B.M.; Polonskaya, F.I. (1972)
Opredelenie
0,O-dietil-S-(6-khlorbenzoksazolinil-3-metil)ditiofosfata
(fozalona) v yablokakh metodom tonkosloinoi khromatografii.
0,0-d iethyl-S-(6-chlorobenzoxazolin-3-ylmethyl)d ithiophosphate
(phosalone) in apples by thin-layer chromatography.] Problemy
Analiticheskoi Khimii. [Problems of Analytical Chemistry.]
2:70-73.
005016119 Kuteev, F.S.; Zharkikh, M.D. (1974) Primeneniye
kolorimetricheskikh metodov dlya opredeleniya khlorofosa,
benzofosfata i metilnitrofosa v ob'yektakh lesnogo biotsenoza.
Use of colorimetric methods for determination of chlorophos,
benzophosphate and methylnitrophos in objects of the forest
biocenose (residues).] Khimiya v Sel'skom Khozyaistve.
005016025 Kuz'minskaya, U.A.; Yakushenko, V.E.; Bersan, L.V. (1978)
Vozdeystviye dlitel'nogo postupleniya nekotorykh pestitsidov na
aktivnost1 detoksitsiruyushchey sistemy pecheni. [Effect of
long-term exposure to pesticides on the detoxifying activity of
the liver.] [abstract]. Gigiena Truda i Professional'nye
Zabolevaniya. [Labor Hygiene and Occupational Diseases.]
7(7):57.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005014684 Laplanche, A.; Martin, G. (1976) Contribution a la lutte contre
les nuisances dues aux organo-phosphores: application aux eaux
d1alimentation. [Contribution to the control of
organophosphorus pollutants: application to feed water.]
Journal Francais d'Hydrologie 7(19):11-18.
000006708 Laurent, M.; Buys, M.; Sasmayoux, J.C. (1968) Phosalone: G.L.C. De-
termination of Phosalone and 12244 R.P. in Apples and in Grape
Extracts from the U.S.A.: D.S.Ph./D.S. An. Nord No. 12864. (Un-
published study received Jun 14, 1968 under 8F0668; prepared by
Societe des Usines Chimiques Rhone-Poulenc, submitted by Chip-
man Chemical Co., Inc., Burlingame, Calif.; CDL:091171-J)
000006646 Laurent, M.M. (1964) Titration of the Residues of 11974 R.P. in
Plant Tissue: D.R.An No. 2792. Includes method dated Sep 18,
1963. (English translation; unpublished study received 1965 un-
der 359-EX-46; prepared by Societe des Usines Chimiques Rhone-
Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth Junction,
N.J.; CDL:123396-G)
005005241 LeBel, G.L.; Williams, D.T.; Griffith, G.; Benoit, F.M. (1979)
Isolation and concentration of organophosphorus pesticides from
drinking water at the ng/L level, using macroreticular resin.
Journal of the Association of Official Analytical Chemists
62(2):241-249.
000006656 Lelievre, M. (1974) Phosalone—Toxicology: Data from Literature:
S.U.C.R.P.—D.S.Ph. No. 17762. (English translation; unpub-
lished study received Nov 17, 1975 under 359-620; prepared by
Societe des Usines Chimiques Rhone-Poulenc, submitted by Rhone-
Poulenc, Inc., Monmouth Junction, N.J.; CDL:223344-F)
005013279 Leshchev, V.V.; Smirnov, A.M.; Talanov, G.A. (1974) Opredelenie
fozalona v mede metodami tonkosloinoi i gazo-zhidkostnoi
khromatografii. [Determination of phosalone in honey by
thin-layer and gas-liquid chroma tography.] Veterinariya
(Moscow). [Veterinary Science.] (6):106-107.
005015528 Leshchev, V.V.; Talanov, G.A. (1976) Opredelenie FOS v kormakh i
produktakh. [Determination of organophosphorus insecticides in
feeds and animal products.] Veterinariya (Moscow).
000006430 Lillie, D.T. (1972) Final Report: District Project No. F 72-57.
(Unpublished study received Mar 16, 1973 under 359-620; prepared
by Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:008914-B)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006747 Lillie, D.T.; Carman, G. (1971) Final Report: District Project
No. FD 71-91. (Unpublished study received on unknown date under
2F1193; prepared in cooperation with Univ. of California—River-
side, submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:
093518-G)
000006748 Lillie, D.T.; Carman, G. (1971) Final Report: District Project
No. FD 71-92. (Unpublished study received on unknown date under
2F1193; prepared by Univ. of California—Riverside, submitted by
Rhodia, Inc., New Brunswick, N.J.; CDL:093518-H)
005008786 Lisovik, Z.A.; Gorbacheva, N.A. (1977) Gazokhromatograficheskoe
opredelenie metafosa, metilnitrofosa i metiletiltiofosa v
krovi. [Gas-chromatographic determination of metaphos,
methylnitrophos and methylethylthiophos in blood.] Farmatsiya
(Moscow). [Pharmacy.] 26(5):44-51.
005011351 Makarova, S.V.; Bel'skaya, G.; Soboleva, D.A. (1972) Analiz
ftalofosa i benzofosfata iodometricheskim metodom. [Analysis
of phthalophos and benzophosphate by an iodometric titration
method.] Khimiya v Sel'skom Khozyaistve. [Chemistry in
Agriculture.] 10(5):361-362.
GS0027008 Makhijani, G.P. (1973) Memorandum sent to Bart J. Pum. Chemistry
Branch, RD. dated May 22, 1973. Concerns the results of method
trial for phosalone in beef fat. PPs ttOF0983 and 2F1193; EAPs
#2H5013 and 2H2668.
005012298 Makhnovsky, I.K.; Kim, Z.I.; Guzeev, G.F.; Khalilov, S. (1974)
Ostatochnye kolichestva benzofosfata i metilnitrofosa v
rasteniyakh i pochve. [Residual amounts of benzophosphate and
methylnitrophos in plants and soil.] Lesnoe Khozyaistvo.
005018094 Malinin, O.A. (1979) Opredelenie fosfororganicheskikh pestitsidov.
(Moscow). [Veterinary Science.] (l):72-74.
005014948 Man'ko, N.N. (1970) Obosnovanie predel'no dopustimoi
kontsentratsii fozalona v vozdukhe rabochei zony. [Basis for
the maximum permissible concentration of phosalone in the air
of a work zone.] Gigiena Truda i Professional'nye
Zabolevaniya. [Labor Hygiene and Occupational Diseases.]
14(12):46-48.
005017341 Man'ko, N.N. (1970) Toksikologiia i gigiena primeneniia fozalona.
Primeneniya, Toksikologiya Pestitsidov i Klinika Ortavlenii.
Clinical Aspects of Poisoning.] 8(2):270-277.
005013284 Man'ko, N.N.; Pis'mennaya, M.V.; Akoronko, S.L. (1974)
Gigienicheskie reglamenty fozalona dlia produktov pitaniia.
Pitaniya. [Problems of Nutrition.] 33(5):62-67.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005014951 Mandel'baum, Y.A.; Nikishova, G.E.; Nagayuk, I.N., inventors;
(1975) Sposob polucheniya dialkil-S-imidometilditiofosfatov.
dithiophosphates.] U.S.S.R. opisanie izobreteniya 480,717.
Aug 15. 2 p. Int. Cl. C 07f 9/16.
000006574 Mazuret, A. (1971) Phosalone, Methyl-azinphos and Parathion: Acute
Percutaneous Toxicity in the Rat: R.P.—D.S.Ph. No. 15544. (Un-
published study received May 25, 1973 under 3F1337; prepared by
Societe des Usines Chimiques Rhone-Poulenc, submitted by Rhodia,
Inc., New Brunswick, N.J.; CDL:093575-B)
005009810 McCann, J.S.; Jasper, R.LL. (1972) Vertebral damage to bluegills
exposed to acutely toxic levels of pesticides. Transactions of
the American Fisheries Society 101(2):317-322.
005004310 McCully, K.A. (1972) Report on phosphated pesticides. Journal of
the Association of Official Analytical Chemists 55(2):291-297-
000006062 McGill, L.A. (1972) Effect of Zolone EC on the Flavor of Stone
Fruits: Part 3. (Unpublished study received Mar 16, 1973 under
359-620; prepared by Oregon State Univ., Dept. of Food Science
and Technology, submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:096444-C)
000006587 McGill, L.A. (1972) Flavor Evaluation Report. (Unpublished study
received May 25, 1973 under 3F1337; prepared by Oregon State
Univ., Dept. of Food Science and Technology, submitted by
Rhodia, Inc., New Brunswick, N.J.; CDL:093575-AJ)
000006433 McGill, L.A. (1972) Flavor Evaluation Report: [Zolone]. (Unpub-
lished study received Mar 16, 1973 under 359-620; prepared by
Oregon State Univ., Dept. of Food Science and Technology, sub-
mitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:
008914-E)
000006432 McGill, L.A. (1973) Flavor Evaluation Report. (Unpublished study
received Mar 16, 1973 under 359-620; prepared by Oregon State
Univ., Dept. of Food Science and Technology, submitted by Rhone-
Poulenc, Inc., Monmouth Junction, N.J.; CDL:008914-D)
GS0027023 McGill, L.A. (1973) Flovor Evaluation Report. Test Numbers S204-
73, S206-73. (Unpublished study concerning fresh french prunes
treated with Zolne EC, received Sep 24, 1973 under ?: Prepared by
Department of Food Science and Technology, Oregon State
University, submitted by Rhodia, Inc., Chipman Division)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
GS0027022 McGill, L.A. (1973) Flavor Evaluation Report. Test Numbers S205,
S243, S244-73. (Unpublished study concerning fresh, canned, and
frozen Halford peaches treated with Zolone EC, Received Oct 5,
1973 under ?; prepared by Department of Food Sciences and
Technology, Oregon State University, submitted by Rhodia, Inc.,
Chipman Division)
000006494 McGinnis, C.H., Jr. (1974) The Effect of Dietary Phosalone on Body
Weight, Feed Consumption, Reproduction, and the Production of
Phosalone Residues in Body Tissues and Eggs of Bobwhite Quail:
Research Report No. CHM 74:40. (Unpublished study received
Jun 13, 1974 under 359-620; prepared by Rhodia, Inc., submitted
by Rhone-Poulenc, Inc, Monmouth Junction, N.J.; CDL:120351-U)
005013548 McMahon, B.; Burke, J.A. (1978) Analytical behavior data for
chemicals determined using AOAC multiresidue methodology for
pesticide residues in foods. Journal of the Association of
Official Analytical Chemists 61(3):640-652.
005015601 Mel'nikov, N.N. (1974) Pestitsidy i okruzhaiushchaia sreda.
Razlozhenie fosfororganicheskikh pestitsidov. [Pesticides and
the environment. Decomposition of organophosphorus
pesticides.] Khimiya v Sel'skom Khozyaistve. [Chemistry in
Agriculture.] 12(4):289-297.
005016150 Mel'nikov, N.N. (1978) Pestitsidy v sel'skom khozyaistve v
shveitsarii v 1978 g. [Pesticides in agriculture in Sweden in
1978.] Khimiya v Sel'skom Khozyaistve. [Chemistry in
Agriculture.] 16(11):19-22.
005015602 Mel'tser, F.R.; Novikova, K.F. (1970) Khromatofotometricheskiy
metod opredeleniya ostatochnykh kolichestv fozalona v
rastitel'nykh pishchevykh produktakh. [Chromatophotometric
method for determining residual amounts of phosalone in plant
foods.] Khimiya v Sel'skom Khozyaistve. [Chemistry in
Agriculture.] 8(9):680-682.
005016359 Mel'tser, F.R.; Novikova, K.F. (1971) Novyi spetsificheskii
kolorimetricheskii metod opredeleniya ostatochnykh kolichestv
fozalona v rastitel'nykh ob'ektakh. [Specific colorimetric
determination of residual quantities of phosalone in plant
materials. ] Pages 295-299, I_n Trudy Vsesoyuznogo Soveshchaniya
po Issledovaniya Ostatkov Pestitsidov i Profilaktike
Zagryazneniya Imi Produktov Pitaniya, Kormov i Vneshnei Sredy,
Metody Analiza, 2nd. [Transactions of the 2nd All-Union
Conference on the Residues of Pesticides and Prophylaxis of
Contamination by Them of Foodstuffs, Feeds and the Environment,
Methods of Analysis.]; 1970, Tallin. Edited by O.M. Tanm.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005015598 Meltser, F.R.; Novikova, K.F. (1972) Modifikatsiia
kolorimetricheskogo metoda opredeleniia benzofosfata v
rastitelnykh ob'ektakh. [Modification of the colorimetric
method for determination of benzophosphate (phosalone) in
vegetable products.] Voprosy Pitaniya. [Problems of
Nutrition.] 31(2):94-95.
005006261 Mestres, R.; Chevallier, C. (1969) Residus de pesticides: XVIII.
Technique de controle des residus de pesticides a activite
anticholinesterasique dans les fruits et les legumes.
residues by anticholinesterase activity in fruits and
vegetables.] Annales des Falsifications et de 1'Expertise
Chimique 62(684):41-46.
005010241 Metivier, J. (1977) Synthesis of phosalone from naturally
occurring benzoxazolones. Pages 673-687, _In Environmental
Pollution and Human Health: Proceedings of the International
Symposium on Industrial Toxicology; Nov 4-7, 1975. Edited by
S.H. Zaidi. Lucknow, India: Industrial Toxicology Research
Centre.
000006644 Metivier, M. (1964) The Assumed Metabolites of R.P. 11974: R.P.—
D.S.Ph. No. 9552. (English translation; unpublished study re-
ceived 1965 under 359-EX-46; prepared by Societe des Usines Chi-
miques Rhone-Poulenc, submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:123396-E)
005019245 Mikami, A. (1973) Noyaku no teisei—teiryo ni kansuru hoigakuteki
kenkyu. [Analytical method for identification and
determination of pesticides in forensic toxicology.] Nippon
Hoigaku Zasshi. [Japanese Journal of Legal Medicine.]
27(5):316-336.
005016361 Mikhailov, V.S.; Supin, G.S. (1971) Opredelenie ostatochnikh
kolichestv ftalofosa i benzofosfata ostsillopolyarograficheskim
metodom. [Determination of residual amounts of phthalophos and
benzophosphate by an oscillopolarographic method.] Pages
237-240, _In Trudy Vsesoyuznogo Soveshchaniya po Issledovaniyu
Ostatkov Pestitsidov i Profilaktike Zagryazneniya Imi Produktov
Pitaniya, Kormov i Vneshnei Srey, Metody Analiza, 2nd.
of Pesticides and Prophylaxis of Contamination by Them of
Foodstuffs, Feeds and the Environment, Methods of Analysis.];
1970, Tallin. Edited by O.M. Tamm.
005019336 Mirkhaitov, T.; Ikramov, L.T. (1970) Noviye kachestvenniye
reaktsii obnaruzheniya fozalona i ftalofosa. [New qualitative
tests for the detection of phosalone and phthalophos.]
Sudebno-Meditsinskaya Ekspertiza. [Forensic Medical
Examination.] 13(1):29-32.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005014544 Mirkhaitov, T.; Ikramov, L.T. (1974) Ekstraktsiya fozalona i
ftalofosa iz vodnykh rastvorov organicheskimi rastvoritelyami v
zavistimosti ot pH sredy. [Extraction of phosalone and
phthalophos from aqueous solutions by organic solvents as a
function of pH of the medium.] Uzbekskii Khimicheskii Zhurnal.
005020254 Mitic-Muzina, N.; Adamovic, V.; Pantovic, D.; Petrovic, 0.; Sokic,
B. (1971) Prilog proucavanju dinamike degradacije nekih
insekata: II. Degradacija nekih insekticida na plodovima
breskve i kajsije. [A contribution to the study of the
dynamics of the breakdown of some insecticides: II. The
breakdown of some insecticides in the fruits of peach and
apricot.] Zastita Bilja. [Plant Protection.]
22(112/113):51-60.
005017547 Mitic-Muzina, N.; Adamovic, X.; Pantovic, D.; Petrovic, X.; Sokic,
B. (1971) A contribution to the study of the degradation
dynamics of some insecticides. II. Degradation of some
insecticides on peach and apricot fruits. Zastita Bilja.
005016279 Molozhanova, E.G.; Remizova, L.B. (1971) Opredelenie nektorikh
fosfororganicheskikh pestitsidov v pochve pri ikh sovmestnom
prisutstvii. [Determination of certain organophosphorus
pesticides with the combined presence of them.] Pages
177-178, ^n Trudy Vsesoyuzncgo Soveshchaniya po Issledovaniyu
Ostatkov Pestitsidov i Profilaktike Zagryazneniya Imi Produktov
Pitaniya, Kormov i Vneshnei Sredy, Metody Analiza, 2nd.
of Pesticides and Prophylaxis of Contamination by Them of
Foodstuffs, Feeds and the Environment, Methods of Analysis.];
1970, Tallin, USSR. Edited by O.M. Tamm.
005012644 Molozhanova, E.G.; Remizova, L.B. (1973) Metod odnovremennogo
opredeleniya v pochve mikrokolichestv pestitsidov razlichnykh
grupp. [Method of simultaneous determination of
micro-quantities of pesticides in various groups in soils.]
Gigiena i Sanitariya. [Hygiene and Sanitation.] 38(11) :74-75.
005007749 Murtuza, S.M.; Naqvi, S.N.H.; Ashrafi, S.H. (1971) The residual
toxicity of Petkolin in comparison with Phosalone and DDT.
Pakistan Journal of Scientific and Industrial Research
14(4/5):377-379.
005001342 Nagayoshi, H.; Suzuki, K.; Kashiwa, T. (1975) Systematic
identification and determination of pesticides. Part 9:
classification of 89 pesticides and related compounds by
thin-layer chromatography. A translation of: Noyaku Kensasho
Hokoku. [Bulletin of the Agricultural Chemicals Inspection
Station.] 15:22-30.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005015644 Nalbandyan, R.A. (1974) O sokhranenii sevina i fozalona v pochve.
Zashchita Rastenii (Moscow). [Plant Protection.] (3):26.
005015594 Nalbandyan, R.A. (1975) Ostatochnyie kolichestva sevina i
phosalona v listiakh i iagodakh vinograda. [Residual amounts
of.Sevin and phosalone in grapes and grape leaves.] Khimiya v
Sel'skom Khozyaistve. [Chemistry in Agriculture.]
13(9):712-713.
005014541 Nalbandyan, R.A. (1975) Vliyanie atmosfernykh osadkov va stepen1
stabil'nosti pestitsidov. [Effect of atmospheric precipitation
on pesticide stability.] Zashchita Rastenii (Moscow). [Plant
Protection.] (12):25.
000014391 Nash, R.F. (1971) Pecan and Ornamental Plant Insect and Mite Con-
trol Studies. (Unpublished study received Jun 26, 1974 under
100-501; prepared by Clemson Univ., Dept. of Entomology and Eco-
nomic Zoology, submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:094034-P)
005011355 Nazarov, S.S.; Illarionov, A.I. (1978) Toksichnost1
fosfororganicheskikh insektitsidov dlia medonosnykh pchel.
Khimiya v Sel'skom Khozyaistve. [Chemistry in Agriculture.]
16(7):61-63.
005019972 Nazarova, A.A.; Stradomskii, V.B.; Telegina, L.N. (1977)
Issledovanie svetopogloshcheniya prircdnykh vod metodom
UF-spektrofotometrii v tselyakh avtomatozatsii opredeleniya v
nikh organicheskikh veshchestv. [UV-spectrophotometric study
of the light absorption of natural waters for the automated
determination of organic substances in them.]
Gidrokhimicheskie Materialy. [Hydrochemical Materials.]
XLV: 102-108.
005018054 Nedkova-Bratanova, N.; Ivanov, E.; Savov, G.; Michailova, Z.;
Krusteva, A.; Petrova, S. (1979) Effect of the pesticides
phosalone and lindane on the activity of some dipeptidases and
disaccharidases in rat intestinal mucosa. Enzyme
24(5):281-284.
000008934 Nicholson, J.F.; Seay, R.E.; Pate, C.D.; et al. (1975) Test Lannate
L on Pecans for Yellow Pecan Aphid Control. (Unpublished study
received Sep 21, 1976 under 352-342; submitted by E.I. du Pont
de Nemours & Co., Wilmington, Del.; CDL:095289-R)
000012622 Nielsen, D.G. (1973) Phytotoxicity of Selected Insecticides on Rep-
resentative Woody Ornamental Plants—1973. (Unpublished study
received May 29, 1975 under 100-501; submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:115271-AD)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005015604 Nikolaishvili, A.A. (1970) Materialy o deistvii nekotorykh
pestitsidov na britanskuyu shchitovku i eio prarsitov. [The
effect of some pesticides on Britannia scale and its
predators.] Subtropicheskie Kul'tury. [Subtropical Crops.]
4:174-175.
005013286 Nikulina, S.S.; Sokol'skaya, N.P. (1975) Vliyanie nekotorykh
pestitsidov na ontogenez karpa. [Influence of some pesticides
on ontogenesis in carp.] Veterinariya (Moscow). [Veterinary
Science.] (7):94-95.
005012769 Novikova, K.F.; Mel'tser, F.R. (1971) Selektivnyi fotometricheskii
metod opredeleniya mikrogrammovykh kolichestv benzofosfata.
benzophosphate.] Zhurnal Analiticheskoi Khimii. [Journal of
Analytical Chemistry.] XXVI(8):1651-1654.
005014558 Panchenko, S.E. (1975) Stabil'nost' nekotorykh gerbitsidov i
insektsidov v vodnoi srede. [Stability of some herbicides and
insecticides in an aqueous environment.] Pages
96-98, In Mekhanizm Deistviya Gerbitsidov i Sinteticheskikh
Regulyatorov Rosta Rastenii Ikh Sud'ba v Biosfere, Materialy
Mezhdunarodnogo Simpoziuma Stran-Chlenov SEV, 10th. [Mechanism
of Action of Herbicides and Synthetic Plant Growth Regulators
and their Ultimate Fate in Biosphere, Materials of the 10th
International Symposium of Member Countries of the Council for
Mutual Economic Assistance.]; Apr 15-17, Pushchino, USSR. Vol.
2. Edited by M.S. Sokolov. Pushchino, USSR: Akademiya Nauk
SSSR, Nauchnyi Tsentr Biologicheskikh Issledovanii.
000006295 Pasquet, J.; Mazuret, A. (1973) Phosalone Oxygen-Analog (12244
R.P.): Acute Percutaneous Toxicity in the Rat: S.U.C.R.P.—
D.S.Ph. No. 16979. (Unpublished study received Mar 4, 1976
under 6F1753; prepared by Societe des Usines Chimiques Rhone-
Poulenc, submitted by Rhodia, Inc., Monmouth Junction, N.J.;
CDL:095979-K)
005014815 Pavlova, G.A. (1975) Stetorus—khishchnik pautinnogo kleshcha.
(Moscow). [Plant Protection.] (1):23-24.
005015596 Pierrard, G. (1971) Effet de 1'utilisation de la phosalone sur la
qualite de la fibre de coton. [The effect of phosalone usage
on cotton fiber quality.] Mededelingen van de Faculteit
Landbouwwetenschappen, Rijksuniversiteit Gent. [Communications
of the Faculty of Agricultural Sciences, State University of
Ghent.] 36(1):294-299.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005017545 Pis'mennaya, M.V.; Klisenko, M.A. (1969) Opredelenie ftalofoza,
fozalona, fenkaptona, tsidiala metodom tonkosloinoi
khroraatografii v produktakh rastitel'nogo proiskhozbdeniya.
phosalone, phencapton and cidial in plant products.] Gigiena
Primeneniya Toksikologiya Pestitsidov i Klinika Otravlenii.
Clinical Aspects of Poisoning.] 7:591-595.
005016596 Pis'mennaya, M.V.; Klisenko, M.A. (1972) Tonkosloynaya
khromatografiya ostatochnykh kolichestv novykh
fosfororganicheskikh pestitsidov. [Thin layer chromatography
of residual amounts of new organophosphorus pesticides.]
Problemy Analiticheskoi Khimii. [Problems of Analytical
Chemistry.] 2:111-115.
000008886 Poe, S.L. (1973) The Tomato Pinworm in Florida: Bradenton AREC Re-
search Report GC1973-2. (Unpublished study received Dec 20,
1974 under 352-342; prepared by Univ. of Florida, Institute of
Food and Agricultural Sciences, Agricultural Research and Educa-
tion Center, submitted by E.I. du Pont de Nemours & Co.; CDL:
022993-D)
000011418 Pollet, O.K. (1975) Pecan Demonstration Orchard Treatments, 1975.
(Unpublished study including letter dated Dec 17, 1976 from O.K.
Pollet and J.B. Aitken to Steve Dumford, received Dec 22, 1977
under 100-501; prepared by Clemson Univ., Cooperative Extension
Service, Dept. of Entomology, submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:232600-G)
GS0027018 Popendorf, W. (1980) Exploring citrus harvesters' exposure to
pesticides contaminated foliar dust. Am. Ind. Hyg. Assoc. J. 41:
000006792 Posner, S. (1971) Cow-Feeding Study with Phosalone (Technical)
Insecticide (Dairy Cattle)—Biological Phase. (Unpublished
study including letter dated Jul 26, 1971 from L.C. Brown to
Lee E. TerBush, received Jun 13, 1974 under 359-620; prepared by
Biometric Testing, Inc. for Rhodia, Inc., submitted by Rhone-
Poulenc, Inc., Monmouth Junction, N.J.; CDL:120351-T)
000006761 Posner, S. (1971) Cow-Feeding Study with Phosalone (Technical)
Insecticide (Dairy Cattle)—Biological Phase. (Unpublished
study including project no. 49-181, received Jun 26, 1972 under
OF0983; prepared in cooperation with Biometric Testing, Inc.,
submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:091691-C)
000006630 Preiser, F.A.; Glass, E.H. (1968) Report No. BB 68-86. (Unpub-
lished study received Dec 22, 1969 under 359-626; prepared in
cooperation with Cornell Univ., submitted by Rhone-Poulenc,
Inc., Monmouth Junction, N.J.; CDL:003174-H)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006600 Preiser, F.A.; Semel, M. (1966) Zolone EC—Potatoes: Final Report
No. BB 66-120. (Unpublished study received Dec 7, 1972 under
3F1337; prepared in cooperation with Cornell Univ., submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:094849-V)
000006479 Preiser, F.A.; Taschenberg, E.F. (1968) Report No. BB 68-91. (Un-
published study received Nov 18, 1971 under 359-626; prepared
in cooperation with Cornell Univ., submitted by Rhone-Poulenc,
Inc., Monmouth Junction, N.J.; CDL:003175-T)
005017308 Prishchepa, I.A. (1974) Vliianie insektitsidno-gerbitsidnykh
smesei na napravlennost1 uglevodnogo obmena v rasteniiakh
iachmenia. [Effect of insecticide-herbicidal mixtures on the
direction of carbohydrate metabolism in barley plants.] Pages
82-84, _In Aktual'nye Voprosy Zashchity Rastenii v BSSR,
Materialy Respublikanskoi Konferentsii Molodykh Uchenykh, 1st.
Materials of the 1st Republic Conference of Young Scientists.];
1974, Minsk, USSR. Edited by A.L. Ambrosov and V.V. Nikolaeva.
Minsk, USSR: Belorusskii Nauchno-Issledovatel'skii Institut
Zemledeliya.
005017487 Prishchepa, I.A.; Samersov, V.F. (1978) Deistvie
ger'ididno-insektididnykh smesei na uri raziykh urovnyakh
pitaniya. [Effect of herbicide-insecticide mixtures on the
yield of barley grain at different nutritional levels.]
Agrokhimiya. [Agricultural Chemistry.] (10):117-121.
005012768 Pristavko, V.P.; Degtyarev, B.C.; Chaika, V.N. (1976)
Elektrofiziologicheskaya reaktsiya obonyaniya yablonnoi
plodozhorki Laspeyresia pomonella L. kak vozmozhpyi
ekspress-metod opredeleniya toksichnosti i soderzhaniya
insektitsidov. [Electrophysiological reaction of the sense of
smell of the lesser apple worm Laspeyresia pomonella L. as a
possible quick test for determining toxicity and content of
insecticides.] Doklady Akademii Nauk SSSR. [Proceedings of
the Academy of Sciences of the USSR.] 228(4):999-1000.
005014277 Pruszynski, S.; Cone, W.W. (1972) Relationships
between Phytoseiulus persimilis and other enemies of the
twospotted spider mite on hops. Environmental Entomology
1(4):431-433.
005015536 Pruszynski, S.; Cone, W.W. (1973) Biological observations
of Typhlodromus occidentalis (Acarina: Phytoseiidae) on hops.
Annals of the Entomological Society of America 66(1):47-51.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005013281 Pujman, V. (1972) Zmeny krevniho obrazu bazantu po podani
nekterych pesticid. [Blood picture changes in pheasants
following the administration of some pesticides.] [abstract].
Ceskoslovenska Fysiologie. [Czechoslovak Physiology.]
21(4):380.
005017094 Pulatov, B.A.; Antonovich, E.A. (1975) Vliyanie nekotorykh
fosfororganicheskikh pestitsidov i gerbitsidov na khimicheskii
sostav i pitatel'nuyu tsennost1 sel'skokhozyaistvennykh
kul'tur. [Effect of some organophosphorous pesticides and
herbicides on the chemical composition and nutritional value of
agricultural crops.] Meditsinskii Zhurnal Uzbekistana 9:44-46.
005008144 Rajukkannu, K.; Saivaraj, K.; Vasudevan, P.; Balasubramanian, M.
(1978) Residues of methyl parathion, quinalphos, phosalone and
fenitrothion in/on okra [letter]. Current Science
47(20):782-783.
005009336 Rashid, S.; Roohi, R.A.; Naqvi, S.N.H. (1973) Characterization of
acid phosphatase and its relation with insecticide metabolism
in Bruchus chinensis (Linnaeus). Pages
209-218, In Environmental Quality and Safety. Vol. 2. New
York: Academic Press.
005014546 Rasulev, B.D.; Tashbekov, T.U. (1972) Pestitsidy, mineral'nye
udobreniya, i kachestvo plodov yabloni. [Pesticides, mineral
fertilizers, and the quality of apples.] Meditsinskii Zhurnal
Uzbekistana. [Medical Journal of Uzbekistan.] (5):24-26.
000006493 Rausina, G. (1974) Report to Rhodia, Inc., Chipman Division: Four-
Day Static Aquatic Toxicity study with Zolone EC in Shore Crabs:
IBT No. 621-04483. (Unpublished study received Jun 13, 1974
under 359-620; prepared by Industrial Bio-Test Laboratories,
Inc. for Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Mon-
mouth Junction, N.J.; CDL:120351-S)
000006492 Rausina, G. (1974) Report to Rhodia, Inc., Chipman Division: Four-
Day Static Aquatic Toxicity Study with Zolone EC in Brown
Shrimp, February 15, 1974: IBT No. 621-04483. (Unpublished
study received Jun 13, 1974 under 359-620; prepared by Indus-
trial Bio-Test Laboratories, Inc., submitted by Rhone-Poulenc,
Inc., Monmouth Junction, N.J.; CDL:120351-R)
000006933 Reed, L.R. (1964) Summary & Review Report: Residue Sampling Pro-
gram for New Pesticides. (Unpublished study received
Apr 17, 1964 under 7G0575; submitted by Chipman Chemical Co.,
Inc., Burlingame, Calif.; CDL:090736-CU)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006692 Reed, L.R. (1966) Insecticide—Phosalone—RP11974: SR/4/66. (Eng-
lish translation of report no. 688; unpublished study received
Dec 15, 1966 under 7G0575; prepared by Rhone-Poulenc, Inc. in
cooperation with Centre Technique Interprofessionnel des Olea—
gineax Metropolitains, I.N.T.A., Bee Station and Univ. of Cali-
fornia—Riverside, submitted by Chipman Chemical Co., Inc., Bur-
lingame, Calif.; CDL:090729-G)
005011159 Renvall, S. (1977) Insektsmedel i bin och honung. [Insecticides
in bees and honey.] Vaxtskyddsnotiser. [Notes on Plant
Protection.] 41(3):77-79.
GS0027026 Rhodia, Incorporated, Chipman Division (19??). The Results of
Tests on the Amount of Phosalone Reisudes Remaining in or on
Artichokes. Including a Description of the Analytical Method
Used. Test Numbers 100472-036, 100471-035, 100471-036. Report
2733, 2734, 170473-050. (Unpublished study received ? under
3E1401)
000006659 Rhodia, Incorporated (19??) [Toxicity to Bees]. (pp. 5,8 only; un-
published study received Nov 17, 1975 under 359-620; submitted
by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:223344-M)
000006736 Rhodia, Incorporated (19??) Analytical Methods. (Unpublished study
received Jun 8, 1973 under 3H5038; CDL:221773-1)
000006108 Rhodia, Incorporated (19??) Contents Summary Statements. Summary
of studies 095979-H through 095979-M. (Unpublished study re-
ceived Mar 4, 1976 under 6F1753; CDL:095979-G)
000006072 Rhodia, Incorporated (19??) Oxygen Analog of Phosalone, R.P. 12244.
(Unpublished study received Oct 16, 1967 under 9F0759; CDL:
093071-H)
000006120 Rhodia, Incorporated (19??) Phosalone in Dairy Cattle Tissue: Sum-
mary. (Unpublished study received May 6, 1970 under OF0983;
CDL:093292-G)
000006173 Rhodia, Incorporated (19??) Summary: Zolone WP Residue—Grapes.
(Unpublished study received 1971 under 359-626; submitted by
Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:122862-A)
000006106 Rhodia, Incorporated (19??) Technical Data Sheet. (Unpublished
study received Mar 4, 1976 under 6F1753; CDL:095979-C)
000006239 Rhodia, Incorporated (1964) Final Report: Tart Cherries: Report
No. C 64-24. (Unpublished study received Mar 26, 1971 under
1F1155; CDL:093474-G)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006589 Rhodia, Incorporated (1966) Phosalone—Potato Petition. Summary of
studies 093575-B through 093575-D. (Unpublished study received
May 25, 1973 under 3F1337; CDL:093575-AL)
000006515 Rhodia, Incorporated (1966) Zolone EC: Grapefruit. Summary of
studies 092026-BC and 092026-BE. (Unpublished study received
Feb 16, 1970 under OF0948; CDL:092026-D)
000006516 Rhodia, Incorporated (1966) Zolone EC: Lemons. Summary of studies
092026-BD and 092026-BF. (Unpublished study received Feb 16,
1970 under OF0948; CDL:092026-E)
000006712 Rhodia, Incorporated (1967) Field and Analytical Data: Phosalone
Residue in Apples—Ontario, Canada—1967. (Unpublished study
received Jun 14, 1968 under 8F0668; submitted by Chipman Chemi-
cal Co., Inc., Burlingame, Calif.; CDL:091171-X)
000006717 Rhodia, Incorporated (1967) Phosalone Feeding Test. (Unpublished
study received Jun 14, 1968 under 8F0668; prepared in coopera-
tion with Woodard Research Corp., submitted by Chipman Chemical
Co., Inc., Burlingame, Calif.; CDL:091171-AM)
000006123 Rhodia, Incorporated (1967) Summary: Analysis of Phosalone (RP
11974) Residue in Tissues of Beef Cattle and Sheep. (Unpub-
lished study received May 6, 1970 under OF0983; CDL:093292-J)
000006080 Rhodia, Incorporated (1968) Apples—Phosalone. (Unpublished study
received Sep 12, 1968 under 9F0759; CDL:091306-G)
000006081 Rhodia, Incorporated (1968) Pears—Phosalone. (Unpublished study
received Sep 12, 1968 under 9F0759; CDL:091306-H)
000006122 Rhodia, Incorporated (1968) Reasonable Grounds in Support of the
Petition: [Phosalone]. (Unpublished study received May 6, 1970
under OF0983; CDL:093292-1)
000006704 Rhodia, Incorporated (1968) Residue Data Requirements: [Phosalone].
Summary of studies 091171-F through 091171-M. (Unpublished
study received Jun 14, 1968 under 8F0668; submitted by Chipman
Chemical Co., Inc., Burlingame, Calif.; CDL:091171-E)
000006201 Rhodia, Incorporated (1969?) Stone Fruit Petition: [Phosalone].
(Unpublished study received Mar 26, 1971 under 1F1155; CDL:
093475-P)
000006513 Rhodia, Incorporated (1969) Zolone EC: Pecans. Summary of studies
092026-S through 092026-AB. (Unpublished study received Feb 16,
1970 under OF0948; CDL:092026-B)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006199 Rhodia, Incorporated (1969) Zolone EC: Product Number 300. (Unpub-
lished study received Mar 26, 1971 under 1F1155; CDL:093475-1)
000006200 Rhodia, Incorporated (1969) Zolone WP: PN 304. (Unpublished study
received Mar 26, 1971 under 1F1155; CDL:093475-L)
000006194 Rhodia, Incorporated (1970) Apricots: [Phosalone]. (Unpublished
study received Mar 26, 1971 under 1F1155; CDL:093475-A)
000006195 Rhodia, Incorporated (1970) Cherries: [Phosalone]. (Unpublished
study received Mar 26, 1971 under 1F1155; CDL:093475-B)
000006196 Rhodia, Incorporated (1970) Nectarines: [Phosalone]. (Unpublished
study received Mar 26, 1971 under 1F1155; CDL:093475-C)
000006197 Rhodia, Incorporated (1970) Peaches: [Phosalone]. (Unpublished
study received Mar 26, 1971 under 1F1155; CDL:093475-D)
000006198 Rhodia, Incorporated (1970) Prunes: [Phosalone]. (Unpublished
study received Mar 26, 1971 under 1F1155; CDL:093475-E)
000006382 Rhodia, Incorporated (1970) Zolone EC: Apricots. Summary of stud-
ies 093474-BI through 093474-BQ. (Unpublished study received
May 6, 1970 under OF0983; CDL:091692-AE)
000006381 Rhodia, Incorporated (1970) Zolone EC: Peaches. Summary of studies
093474-N through 093474-R. (Unpublished study received May 6,
1970 under OF0983; CDL:091692-AC)
000006238 Rhodia, Incorporated (1970) Zolone EC: Prunes. Summary of studies
093474-AS through 093474-BH and 093474-BR. (Unpublished study
received Mar 26, 1971 under 1F1155; CDL:093474-F)
000006577 Rhodia, Incorporated (1971?) Reasonable Grounds in Support of the
Petition: [Zolone]. (Unpublished study received May 25, 1973
under 3F1337; CDL:093575-R)
000006210 Rhodia, Incorporated (1971) Phosalone—Tea: Phosalone Residue Stud-
ies. (Unpublished study including letters dated Jul 19, 1972
from J. Metivier and P. Petrinko to Tea Research Association and
Aug 1, 1972 from B. Banerjec to Societe des Usines Chimiques
Rhone-Poulenc, received Jun 8, 1973 under 3H5038; prepared in
cooperation with Tea Research Association and United Planters
Association of Southern India; CDL:221773-B)
000006591 Rhodia, Incorporated (1971) Potatoes: Phytotoxicity Summary. Sum-
mary of studies 094849-D, 094849-E, 094849-AB, 094849-AI,
094849-AO, 094849-AR, 094849-AT and 094849-AW. (Unpublished
study received Dec 7, 1972 under 3F1337; CDL:094849-C)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006510 Rhodia, Incorporated (1971) Zolone EC: Pecans. Summary of studies
091617-L through 091617-X. (Unpublished study received on un-
known date under OF0948; CDL:091617-A)
000006357 Rhodia, Incorporated (1972?) Phosalone Dried Apple Pomace Data.
Includes undated method. (Unpublished study received Jun 26,
1972 under OF0983; prepared in cooperation with Cornell Univ.,
New York State Agricultural Experiment Station, Dept. of Food
Science and Technology; CDL:091691-A)
000006733 Rhodia, Incorporated (1972) Effect of Zolone EC on Stone Fruits;
Phytotoxicity: Part 1. (Unpublished study including district
project nos. F 72-62, F 72-63, Port 72-27, Port 72-32 and Port
72-41, received Mar 16, 1973 under 359-620; submitted by Rhone-
Poulenc, Inc., Monmouth Junction, N.J.; CDL:096444-A)
000006091 Rhodia, Incorporated (1972) Efficacy Data Summary: [Zolone]. Sum-
mary of studies 093518-M through 093518-AB. (Unpublished study
received on unknown date under 2F1193; CDL:093518-L)
000006578 Rhodia, Incorporated (1972) Zolone EC—Potatoes. Summary of stud-
ies 093575-X through 093575-AI. (Unpublished study received
May 25, 1973 under 3F1337; CDL:093575-S)
000006594 Rhodia, Incorporated (1972) Zolone EC: Potatoes. Summary of stud-
ies 094849-P, 094849-Q, and 094849-S through 094849-AW. (Unpub-
lished study received Dec 7, 1972 under 3F1337; CDL:094849-G)
000006061 Rhodia, Incorporated (1973) Effect of Zolone EC on Yield and Qual-
ity of Stone Fruits: Part 2. (Unpublished study including
letters dated Jan 4, 1973 from F.R. Hall to Julius Szabo; Jun
30, 1972 from S.C. Jones to Everett P. Smyth; Aug 25, 1972 from
J.B. Curtis to D.I. Wang; Nov 17, 1972 from G.R. Garner to
Harold D. Knobel; Aug 23, 1972 from J.C. Taylor to Jim Bone;
Aug 31, 1972 from R. Brown to D.I. Wang; July 10, 1972 from G.R.
Post to E. Lillie; Jul 3, 1972 from R.E. Rice to D.T. Lillie;
Jul 12, 1972 from J.E. Dibble to D.T. Lillie; Sep 11, 1972 from
A.D. Saso to Der I Wang; Aug 24, 1972 from R.J. Franklin to Dr.
Wang, and Jan 18, 1973 from A.J. Howitt to Julius G. Szabo, re-
ceived Mar 16, 1973 under 359-620; submitted by Rhone-Poulenc,
Inc., Monmouth Junction, N.J.; CDL:096444-B)
000006112 Rhodia, Incorporated (1974?) Zolone—Alflafa [sic]: Reasonable
Grounds in Support of the Petition. (Unpublished study received
Mar 4, 1976 under 6F1753; CDL:095979-N)
000006488 Rhodia, Incorporated (1974) Environmental Impact Studies for Phosa-
lone. (Unpublished study including PR notice 70-15, received
Jun 13, 1974 under 359-620; submitted by Rhone-Poulenc, Inc.,
Monmouth Junction, N.J.; CDL:120351-A)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006148 Rhodia, Incorporated (1974) Zolone—Carrot: Quarterly Report Ending
August 22, 1974. (Unpublished study received Sep 24, 1974 under
359-EX-52; submitted by Rhone-Poulenc, Inc., Monmouth Junction,
N.J.; CDL:225864-A)
000006965 Rhodia, Incorporated (1975?) Content Summary Statements. Summary
of studies 098088-B through 098088-P and 098088-T through
098088-Y. (Unpublished study received Mar 4, 1976 under 6F1753;
CDL:098088-A)
000006168 Rhodia, Incorporated (1975) Summary Report on the Zolone-Carrot Ex-
perimental Use Program for the Period May 22, 1974 to May 21,
1975. (Unpublished study received Jul 1, 1975 under 359-EX-52;
submitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:
225861-A)
000006662 Rhodia, Incorporated (1977?) Introduction: [Phosalone]. Summary of
studies 229759-B through 229759-J. (Unpublished study received
May 10, 1977 under 359-620; submitted by Rhone-Poulenc, Inc.,
Monmouth Junction, N.J.; CDL:229759-A)
000006489 Rhone-Poulenc, Incorporated (1967) Toxicity to Bees. Summary of
studies 120351-G through 120351-1. (Unpublished study received
Jun 13, 1974 under 359-620; prepared in cooperation with Wash-
ington State Univ. and Univ. of California, Agricultural Exten-
sion Service; CDL:120351-F)
000006782 Rhone-Poulenc, Incorporated (1969) Zolone WP Formulation: Apples.
Summary of studies 003174-A through 003174-T. (Unpublished
study received Dec 22, 1969 under 359-626; CDL:003174-V)
005015300 Richard, Y.; Brener, L. (1978) Organic materials produced upon
ozonization of water. Pages 169-188, In Ozone/Chlorine Dioxide
Oxidation Products of Organic Materials, Proceedings of a
Conference; Nov 17-19, 1976, Cincinnati, Ohio. Edited by R.G.
Rice and J.A. Cotruvo. Cleveland, Ohio: Ozone Press
International.
005012670 Rovinskii, F.Y.; Gasilina, N.K. (1978) Problemy analiza pri
kontrole zagryazneniya okruzhayushchei sredy. [Analytical
problems in monitoring environmental pollution.] Zhurnal
Analiticheskoi Khimii. [Journal of Analytical Chemistry.]
XXXIII(1):160-170.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005016978 Sabirova, D.U.; Bobyreva, T.V. (1974) Vliyaniye fozalona i
ftalofosa na khishchnika pautinnogo kleshcha Stethorus
on Stethorus punctillum Ws., a predator of the spider mite.]
Pages 138-139, JEn Materialy S'ezda Vsesoyuznogo
Entomologicheskogo Obshchestva, 7th. [Materials of the 7th
Congress of the Ail-Union Entomological Society.]; 1974,
Leningrad, USSR. Vol. 2. Edited by I.M. Kerzhner. Leningrad,
USSR: Akademiya Nauk SSSR, Zoologicheskii Institut.
005006146 Safonov, N.M. (1968) Toksikologicheskaya kharakteristika novogo
fosfororganicheskogo insektitsida fozalona. [Toxicological
characteristics of the new organophosphorus insecticide
phosalone; preliminary data.] Gigiena Truda i Professional'nye
Zabolevaniya. [Labor Hygiene and Occupational Diseases.]
12(12):43-44.
005014686 Sagredos, A.N.; Eckert, W.R. (1976) Methoden zur Bestimmung von
Phytopharmaka in Tabak und Tabakerzeugnissen. II. Mitteilung:
Zur Simultanbestimmung von hexanloeslichen
Organophosphor-Pflanzenschutzmitteln. [Methods for the
determination of phytopharmaceuticals in tobacco and tobacco
products. Part II. Simultaneous determination of
hexane-soluble organophosphorus pesticides.] Beitraege zur
Tabakforschung 8(7):447-454.
005015603 Samersov, V.F.; Prishchepa, I.A. (1976) Insektitsidno-gerbitsidnye
smesi dlya zashity yachmenya. [Insecticide-herbicide mixtures
for protecting barley.] Khimiya v Sel'skom Khozyaistve.
005011353 Samersov, V.F.; Prishchepa, I.A. (1978) Vliyanie
gerbitsidno-insektotsidnykh smesei na soderzhanie azotistykh
seshchestv v rasteniyakh iachmenia. [Effect of
herbicide-insecticide mixtures on the level of nitrogenous
substances in barley plants.] Khimiya v Sel'skom Khozyaistve.
000006128 Schafer, C.A.; Stier, E.F. (1974) Sensory Evaluation Report on
Carrot. (Unpublished study received Feb 12, 1974 under 4E1468;
prepared in cooperation with Rutgers Univ., Dapt. of Food
Science, submitted by Interregional Research Project No. 4, New
Brunswick, N.J.; CDL:093909-1)
000006694 Scott, W.J.; Beliles, R.P. (1966) Phosalone: Potentiation Studies
in the Rat with Marketed Pesticides: Addendum. (Unpublished
study received Dec 15, 1966 under 7G0575; prepared by Wbcdard
Research Corp., submitted by Chipman Chemical Co., Inc., Bur-
lingame, Calif.; CDL:090729-J)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
OC5016280 Sedykh, A.S.; Abelentseva, G.M.; Ivanova, G.B. (1971)
Chuvstvitel'nost1 biologicheskogo i
tonkosloyno-khromatograficheskogo metodov opredeleniya ostatkov
pestitsidov. [Sensitivity of biological and thin-layer
chromatographic methods of determining pesticide residues.]
Pages 277-278, In Proceedings of the 13th International
Congress of Entomology; Aug 2-9, 1968, Moscow. Vol. 2. Edited
by G.Y. Bei-Bienko.
005016022 Sedykh, A.S.; Popov, P.V.; Abelentseva, G.M.; Shapovalova, G.K.;
Ivanova, G.B. (1972) Chuvstvitel'nost1 biologicheskogo i
tonkosloinokhromatograficheskogo metodov opredeleniya ostatkov
pestitsidov. [Sensitivity of biological and thin-layer
chromatographic methods of determining pesticide residues.]
Problemy Analiticheskoi Khimii. [Problems of Analytical
Chemistry.] 2:130-135.
005015382 Semenova, S.A.; Golubeva, Z.Z.; Siforova, T.A. (1967) Toksichnost'
nekotorykh fosfororganicheskikh insectoakaritsidov dlya
pautinnogo kleshcha i poleznykh nasekomykh. [Toxicity of some
organophosphorus acaricides for spider mites and useful
insects.] Khimiya v Sel'skom Khozyaistve. [Chemistry in
Agriculture.] 5(12):61.
005007625 Serat, W.F.; Bailey, J.B. (1974) Estimating the relative
toxicologic potential of each pesticide in a mixture of
residues on foliage. Bulletin of Environmental Contamination
and Toxicology 12(6):682-686.
005013283 Shakhsuvarian, N.V. (1972) Vliianie zolona na rasteniia
khlopchatnika pri maloob'emnom opryskanii. [Effect of Zolone
on cotton plants during low-volume spraying„] Khimiya v
Sel'skom Khozyaistve. [Chemistry in Agriculture.]
10(4):282-283.
005013282 Shakhsuvarian, N.V.; Stepanov, F.A. (1974) Vliianie benzofosfata i
gardony na nekotorye fiziologi-biokhimicheskie protsessy v
rasteniiakh khlopchatnika pri maloob'emnom opryskanii. [Effect
of benzophosphate and Gardona on certain physiological and
biochemical processes in cotton plants during low-volume
spraying.] Khimiya v Sel'skom Khozyaistve. [Chemistry in
Agriculture.] 12(8):588-589.
005013871 Shapovalova, G.K.; Galitsina, V.V. (1973) Vliyanie vodorastvorimoi
plenki na insektitsidnost' benzofosfata. [The effect of a
water soluble film on the insecticidal activity of
benzophosphate.] Khimiya v Sel'skom Khozyaistve. [Chemistry
in Agriculture.] 11(2):117.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005015597
005018184
005010412
005014276
005014465
005014822
005019956
000006243
000006639
Shapovalova, G.K.; Sedykh, A.S.; Abelentseva, G.M. (1970) Ob
effektivnosti primeneniia ftalofosa i benzofosfata protiv
kryzhovnikovoi ognevki i ostatkakh insektitsidov na iagodakh.
combat gooseberry moth ( Zophodia convolutella ), and
insecticide residues on the berries.] Khimiya v Sel'skom
Khozyaistve. [Chemistry in Agriculture.] 8(8):594-595.
Sharashidze, O.V.; Bakanidze, M.S. (1975) Vliyanie razlichnykh
fosfororganicheskikh preparatov na fiziologo-biokhimicheskie
protessy chainogo rasteniya i na kachestvo gotovoi produktsii
chaya. [Effect of various organophosphorus preparations on the
physiological-biochemical processes of tea plants and on the
quality of prepared tea products.] Subtropicheskie Kul'tury.
Shaw, F.R.; Callahan, R.A.; Miller, M.C. (1966) Rates of
disappearance of Zolone and Imidan from alfalfa. Journal of
Economic Entomology 59(6):1524-1525.
Shinde, V.P.; Gatlewar, W.N.; Sansare, G.M.; Ramachandran, K.;
Athlekar, S.V.; Mhatre, N. (1978) Evaluation of tolerability of
phosalone (Zolone) 35% EC, an organophosphatic insecticide, by
human beings exposed to aerial spray under Indian field
conditions—part I. Pesticides 12(8):23-34,36.
Shoyama, M. (1977) Hakuso oyobi gasu kuromatografui ni yoru
satchuzai no ensoku na dotei no tame n& benzokuho.
insecticides by thin-layer and gas chromatography.] Bunseki
Kagaku. [Japan Analyst.] 26(7):499-502.
Shoyama, M.; Miyachi, Y.; Sakakibara, J. (1976) Enka palladium to
p-nitroso N,N-diethylaniline wo riyo shita ganiwo yuki rinkei
sacchuzai no hishoku teiryo. [Colorimetric determination of
organothiophosphorus pesticides with palladium chloride and
p-nitroso N,N-diethylaniline.] Bunseki Kagaku. [Japan
Analyst.] 25(3):179-182.
Singh, B.; Dhaliwai, G.S.; Kalra, R.L. (1980) Residues of
quinalphos and phosalone in tomato. Bulletin of Environmental
Contamination and Toxicology 24(3):423-426.
Smyth, E.P.; Burkhart, D.; McCollister, E.G. (1969) Final Report:
District Project No. Port 69-19. (Unpublished study received
Mar 26, 1971 under 1F1155; submitted by Rhodia, Inc., New Bruns-
wick, N.J.; CDL:093474-L)
Smyth, E.P.; Hoyt, S. (1969) Summary Report: District Project
No. Port 69-40. (Unpublished study received Dec 22, 1969 under
359-626; submitted by Rhone-Poulenc, Inc., Monmouth Junction,
N.J.; CDL:003174-Q)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006283 Smyth, E.P.; Jones, S.C. (1970) Final Report: District Project
No. Port 70-22. (Unpublished study received Mar 26, 1971 under
1F1155; prepared in cooperation with Oregon State Univ., Ento-
mology Dept., submitted by Rhodia, Inc., New Brunswick, N.J.;
CDL:093474-BD)
000006858 Smyth, E.P.; Westigard, P. (1967) Report No. Port 67-24. (Unpub-
lished study received Jul 5, 1968 under 8F0668; submitted by
Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:092027-BV)
000006641 Societe des Usines Chimiques Rhone-Poulenc (1963) General Charac-
teristics and Properties of Phosalone (R.P. 11974). Summary of
studies 123396-B through 123396-K. (English translation; unpub-
lished study received 1965 under 359-EX-46; submitted by Rhone-
Poulenc, Inc., Monmouth Junction, N.J.; CDL:123396-A)
000006396 Societe des Usines Chimiques Rhone-Poulenc (1966) Phosalone: Data
for the U.S. Public Health Department: R.P.—D.S.Ph. No. 11340.
(Unpublished study received Feb 2, 1967 under 7G0575; submitted
by Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:090727-P)
000006676 Societe des Usines Chimiques Rhone-Poulenc (1968) Phosalone and
Oxygen-Analog (12244 R.P.): Residues in Apples, Pears and
Grapes: R.P.—D.S.Ph. No. 12646. (Unpublished study received
Jun 14, 1968 under 8F0668; submitted by Chipman Chemical Co.,
Inc-., Burlingame, Calif.; CDL:091170-D)
000006674 Societe des Usines Chimiques Rhone-Poulenc (1968) 12244 R.P.:
Oxygen Analog of Phosalone: Acute Oral Toxicity and Anticho-
linesterasic Activity in Vitro: R.P.—D.S.Ph. No. 12644. (Un-
published study received Jun 14, 1968 under 8F0668; submitted by
Chipman Chemical Co., Inc., Burlingame, Calif.; CDL:091170-B)
005018191 Specht, W. (1978) Methode zur raschen Aufarbeitung groesserer
Fettmengen fuer die Analyse von Pestizidrueckstaenden. [Quick
method for processing sizeable quantities of fat for the
analysis of pesticide residues.] Mitteilungsblatt der
GDCh-Fachgruppe Lebensmittelchemie und Gerichtliche Chemie
32(3):51-53.
005008228 Spehar, R.L.; Holcombe, G.W.; Carlson, R.W.; Drummond, R.A. ;
Yount, J.D.; Pickering, Q.H. (1979) Effects of pollution on
freshwater fish. Journal of the Water Pollution Control
Federation 51(6):1616-1694.
000006738 Spencer, W.T.; Hofmaster, R.N. (1974) Final Report: District
Project No. 314574-011. (Unpublished study received May 10,
1977 under 359-620; prepared by Rhodia, Inc. in cooperation
with Virginia Truck and Ornamentals Research Station, submitted
by Rhone-Poulenc, Inc., Monmouth Junction, N.J.; CDL:229758-AY)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005010532 Spynu, Y.I.; Vrochinskiy, K.K. ; Zor'yeva, T.-D. ; Man'ko, N.N.
(1972) Kompleksnoye gigiyenicheskoye normirovaniye novykh
fosfororganischeskikh pestitsidov v ob'yektakh vneshney sredy.
pesticides in environmental objects.] Gigiena i Sanitariya.
005014392 Stevenson, J.H. ; Walker, J. (1975) Oil seed rape and honeybee
poisoning. Pages 497-501, _In Proceedings of the 8th British
Insecticide and Fungicide Conference. London, England:
British Crop Protection Council.
000012490 Stier, E.F. (1965) Flavor Evaluation Report on Tomatoes. (Unpub-
lished study received Nov 10, 1972 under 3F1323; prepared by
Rutgers Univ., submitted by Ciba-Geigy Corp., Greensboro, N.C. ;
CDL:093552-BY)
000006087 Stier, E.F. (1971) Sensory Evaluation Report on Citrus. (Unpub-
lished study received on unknown date under 2F1193; prepared by
Rutgers Univ., Dapt. of Food Science, submitted by Rhodia, Inc.,
New Brunswick, N. J. ; CDL:093518-D)
005019250 Syoyama, M. ; Miyachi, Y. ; Sakakibara, J. (1976) Enkaparajium to
p-nitoroso N,N-jiechiruanirin o riyoshita
ganioyukirinkeisacchuzai no hishokuteiryo. [Colorimetric
determination of organothiophosphorus pesticides with palladium
chloride and p-nitroso-N,N-diethylaniline. ] Bunseki Kagaku.
000006593 Szabo, J. ; Sleesman, J.P. (1971) Zolone EC—Potatoes: Final Report
No. CH 71-103. (Unpublished study received Dec 7, 1972 under
3F1337; prepared in cooperation with Ohio State Univ., Dept. of
Entomology, submitted by Rhodia, Inc., New Brunswick, N. J. ;
CDL:094849-E)
000006592 Szabo, J. ; Wells, A. (1971) Zolone EC — Potatoes: Final Report
No. CH 71-61. (Unpublished study received Dec 7, 1972 under
3F1337; prepared in cooperation with Michigan State Univ., sub-
mitted by Rhodia, Inc., New Brunswick, N. J. ; CDL:094849-D)
005009355 Szalontai, G. (1976) High-performance liquid chroma tog raphy of
organophosphorus insecticides. Journal of Chroma tog raphy
005013358 Tasei, J.N. ; Capou, J. ; Michaud, D. (1977) Action de quelques
insecticides sur une abeille solitaire: Megachile
pesticides on a solitary bee: Megachile pacifica Panz.
(Hymenoptera, Megachilidae) . ] Apidologie 8 (2): 111-127.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005009882 Tawata, S.; Eto, M.; Ishiguro, T. (1978) Studies on
oxazaphospholidines with pesticidal activities: I. Synthesis
and insecticidal activities of 2-chloromethyl-l,3,2-
oxazaphospholidine 2-oxides. Journal of the Faculty of
Agriculture, Kyushu University 22(3):169-177.
005016594 Tigane, E.Y. (1971) Vydelenie chistykh pestitsidnych preparatov iz
ikh tekhnicheskikh smesyei dlia primenieniya v kachestvie
analiticheskikh etalonov. [Separation of pure pesticide
preparations from their technical mixtures "for use as
analytical standards.] Pages 373-375, In Trudy Vsesoyuznogo
Soveshchaniya po Issledovaniyu Ostatkov Pestitsidov i
Profilaktike Zagryazneniya Imi Produktov Pitaniya, Kormov i
Vneshnei Sredy, Metody Analiza, 2nd. [Transactions of the 2nd
Ail-Union Conference on the Residues of Pesticides and
Prophylaxis of Contamination by Them of Foodstuffs, Feeds and
the Environment, Methods of Analysis.]; 1970, Tallin, USSR.
Edited by O.M. Tamm.
005007126 Tolstova, Y.S. ; lonova, Z.A. (1973)
Chuvstivitelnost Trikhogrammy k pestitsidam. [Sensitivity
of Trichogramma to pesticides.] Zaschita Rastenii (Moscow).
000006071 Totman, L.C.; Imming, R.J.; Wbodard, G. (1967) Phosalone: Analysis
of Compound Residue in Tissues of Beef Cattle and Sheep. (Un-
published study received Oct 16, 1967 under 9F0759; prepared by
Woodard Research Corp., submitted by Rhodia, Inc., New Bruns-
wick, N.J.; CDL:093071-E)
005010803 Travis, J.W. ; Hull, L.A.; Miller, J.D. (1978) Toxicity of
insecticides to the aphid predator Coccinella novemnotata .
Environmental Entomology 7(6):785-786.
005014543 Trondina, G.A. (1978) Metod razdel'nogo opredeleniya ftalofosa i
fozalona v rybe i vode. [Method for the separate determination
of phthalophos and phosalone in fish and water.] Veterinariya
(Moscow). [Veterinary Science.] (6):96-98.
GS0027002 U.S.D.A. (1969) Fish Toxicity Laboratory Report. I.D. Number
62841. (Unpublished report concerning the toxicity of Zolone
3EC on bluegills; prepared by the Animal Biology Laboratory, ARS-
PR, ARC. Beltsville, MD)
GS0027001 U.S.D.A. (1969) Fish Toxicity Laboratory Report. I.D. Number
62841. (Unpublished report concerning the toxicity of Zolone
3EC on rainbow trout; prepared by the Animal Biology Laboratory,
ARS-PR, ARC, Beltsville, MD)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005015131 Ubaidullaev, R.; Kamil'dzhanov, A.K. (1976) K toksikologii malykh
kontsentratsii fozalona v atmosfernom vozdukhe. [Toxicology of
low concentrations of phosalone in the atmosphere.] Gigiena i
Sanitariya. [Hygiene and Sanitation.] 41(7):10-14.
005012947 Ubaidullaev, R.U. (1973) Gigienicheskaia otsenka nekotorykh
pestitsidov, primeniaemykh v usloviiakh zharkogo klimata.
climate.] Meditsinskii Zhurnal Uzbekistana. [Medical Journal
of Uzbekistan.] 8:40-44.
005014949 Valenta, V.T.; Zhegas, A.K. (1977) Fitotoksichnost' insektitsidov
dlya sazhentsev sosny. [Phytotoxicity of insecticides for pine
tree seedlings.] Khimiya v Sel'skom Khozyaistve. [Chemistry
in Agriculture.] 15(3):46-50.
005017186 Varchenko, V.N. (1977) Vliyanie sistem opryskivaniya yabloni na
chislennost1 entomofauny. [Influence of systems for spraying
apple trees on the entomofauna population.] Khimiya v Sel'skom
Khozyaistve. [Chemistry in Agriculture.] 15(l):73-75.
005009798 Varma, R.S.; Nobles, W.L. (1968) Synthesis and antibacterial
activity of certain 3-substituted benzoxazolinones. Journal of
Pharmaceutical Sciences 57(1):39-44.
005000787 Verma, S.R.; Bhatnagar, M.C.; Dalela, R.C. (1978) Biocides in
relation to water pollution. Part 2: bioassay studies of few
biocides to a fresh water fish, Channa gachua . Acta
Hydrochimica et Hydrobiologica 6(2):137-144.
005018285 Verma, S.R.; Tyagi, A.K.; Bhatnagar, M.C.; Dalela, R.C. (1979)
Organophosphate poisoning to some fresh water
teleosts—acetylcholinesterase inhibition. Bulletin of
Environmental Contamination and Toxicology 21(4/5):502-506.
005014685 Veschambre, D.; Espanel, G.; Touzeau, J.; Grouiller, A. (1976)
Tomates et residus pesticides. [Tomatoes and pesticide
residues.] Pepinieristes Horticulteurs Maraichers 171:25-29.
005017544 Vioque, A.; Albi, T. (1978) Determinacion de residues de
insecticidas fosforados en aceitunas. [Determination of
phosphorus containing insecticide residues in olives.] Grasas
y Aceites (Seville) 29(1):37-44.
005014540 Vrochinskii, K.K. (1971) Nakoplenie pestitsidov v gidrobiontakh
kak test dlya ikh otsenki eksperimental'noi vodnoi
toksikologii. [Accumulation of pesticides in hydrobionts as a
measure for evaluating experimental water toxicology.]
Eksperimental'naya Vodnaya Toksikologiya. [Experimental Water
Tox icology.] (2):149-163.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005014280 Vrochinskii, K.K. (1972) K prognozironvaniiu dinamiki ostatkov
fozalona v vode vodoemov. [Predicting phosalone residue
dynamics in reservoir water.] Rybnoe Khozyaistvo (Moscow).
005019859 Vrochinskii, K.K. (1973) Vliyanie nekotorykh pestitsidov na
sanitarnii rezhim vodoema i organolepticheskie svoistva vody.
the organoleptic characteristics of the water.]
Eksperimental'naya Vodnaya Toksikologiya. [Experimental Water
Toxicology.] (4):97-103.
005013278 Vylegzhanina, G.F.; Kalmykova, P.G. (1972) Kachestvennyi i
kolichestvennyi metody opredeleniia fozalona v iablokakh i
iablonevykh list'iakh. [Qualitative and quantitative methods
of determination of phosalone in apples and apple leaves.]
Problemy Analiticheskoi Khimii. [Problems of Analytical
Chemistry.] 2:32-38.
000008167 Wagner, H.W. (1972) Compatibility Study of Multiple Spray Material
Combinations. (Unpublished study received Mar 4, 1974 under
352-362; prepared by Canada, Dept. of Agriculture, Research
Station, submitted by E.I. du Pont de Nemours & Co., Wilmington,
Del.; CDL:026710-E)
000006252 Wang, D. (1969) Final Report: District Project No. PAW 69-3. (Un-
published study including district project no. PAW 69-3A, re-
ceived Mar 26, 1971 under 1F1155; submitted by Rhodia, Inc.,
New Brunswick, N.J.; CDL:093474-W)
000006361 Wang, D. (1969) Summary Report: District Project No. PAW 69-6.
(Unpublished study received May 6, 1970 under OF0983; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:091692-D)
000006293 Wang, D. (1970) Final Report: District Project No. PAW 70-10. (Un-
published study received Mar 26, 1971 under 1F1155; prepared in
cooperation with Paul A. Mariani Co., submitted by Rhodia, Inc.,
New Brunswick, N.J.; CDL:093474-BQ)
000006288 Wang, D. (1970) Final Report: District Project No. PAW 70-12. (Un-
published study including district project no. 70-12A, received
Mar 26, 1971 under 1F1155; prepared in cooperation with Paul A.
Mariani Co., submitted by Rhodia, Inc., New Brunswick, N.J.;
CDL:093474-BK)
000006282 Wang, D. (1970) Final Report: District Project No. PAW 70-14. (Un-
published study received Mar 26, 1971 under 1F1155; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:093474-BC)
300006289 Wang, D. (1970) Final Report: District Project No. PAW 70-20 and
20A. (Unpublished study received Mar 26, 1971 under 1F1155;
submitted by Rhodia, Inc., New Brunswick, N.J.; CDL:093474-BM)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006294
000006477
000006114
000006115
000006145
000006431
000006253
000006064
005016364
000006658
Wang, D. (1970) Final Report: District Project No. PAW 70-22. (Un-
published study received Mar 26, 1971 under 1F1155; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:093474-BR)
Wang, D. (1970) Final Report: District Project No. PAW 70-29.
(Unpublished study received Nov 18, 1971 under 359-626; prepared
by Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth
Junction, N.J.; CDL:003175-N)
Wang, D. (1970) Summary Report: District Project No. PAW 70-4c.
(Unpublished study received Sep 2, 1970 under OF0983; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:091693-C)
Wang, D. (1970) Summary Report: District Project No. PAW 70-42.
(Unpublished study received Sep 2, 1970 under OF0983; submitted
by Rhodia, Inc., New Brunswick, N.J.; CDL:091693-D)
Wang, D. (1972) Final Report: District Project No. FW 72-25. (Un-
published study received Mar 16, 1973 under 359-620; prepared by
Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, N.J.; CDL:009830-C)
Wang, D. (1972) Final Report: District Project No. FW 72-25. (Un-
published study received Mar 16, 1973 under 359-620; prepared by
Rhodia, Inc., submitted by Rhone-Poulenc, Inc., Monmouth Junc-
tion, N.J.; CDL:008914-C)
Wang, D.; Kline, N. (1969) Final Report: District Project No. PAW
69-4. (Unpublished study received Mar 26, 1971 under 1F1155;
prepared in cooperation with Niagara Chemical Co., submitted by
Rhodia, Inc., New Brunswick, N.J.; CDL:093474-Y)
Wang, D.; Rough, D. (1970) Final Report: District Project No. FW
71-92. (Unpublished study received Apr 12, 1972 under 1F1155;
prepared in cooperation with Univ. of California, submitted by
Rhodia, Inc., New Brunswick, N.J.; CDL:096445-D)
Wang, R.T. (1975) Phosalon tze bi se ding liang fa. [A
colorimetric method for the determination of phosalone.]
Hsueh. [Chemistry.] (4):108-111.
Hua
Washington State University, Cooperative Extension Service (19??)
Insecticide Toxicity to Honey Bees. (Unpublished study in-
cluding test no. Port 68-67, received Nov 17, 1975 under 359-
620; submitted by Rhone-Poulenc, Inc., Monmouth Junction, N.J.;
CDL:223344-L)
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
005010805 Weintraub, P.P.; Vylegjanina, G.F.; Nesterova, I.P.; Patrashku,
F.I. (1975) Residual amounts of organophosphate insecticides in
plant products. Pages 180-182, Jjn Pesticides: International
Union of Pure and Applied Chemistry Third International
Congress; Jul 3-9, 1974, Helsinki, Finland. Edited by F.
Coulston and F. Korte. Stuttgart, West Germany: George
Thieme. (Environmental quality and safety supplement, vol.
Ill)
005009137 Weintraub, F.P.; Vylegzhanina, G.F.; Dron, L.P.; Kejser, L.S.;
Nesterova, I.P.; Patrashku, F.I. (1978) Pathways of pesticide
dissipation and decomposition. Pages 140-156, Ir± Symposium on
Environmental Transport and Transformation of Pesticides.
Athens, Ga.: U.S. Environmental Protection Agency,
Environmental Research Laboratory. (EPA report no.
EPA-600/9-78-003; available from: NTIS, Springfield, VA; PB 280
714)
005009309 Winterlin, W.; Mourer, C.; Bailey, J.B. (1974) Degradation of four
organophosphate insecticides in grape tissues. Pesticides
Monitoring Journal 8(1):59-65.
000006682 Woodard, G. (1966) [Phosalone Chronic Dog Study: Clinical Chemistry
Determinations Performed at 39-40 Weeks]. (Unpublished study
including letter dated Mar 5, 1966 from G. Woodard to Leslie R.
Reed, received Dec 12, 1966 under 7G0575; prepared by Woodard
Research Corp., submitted by Chipman Chemical Co., Inc., Bur-
lingame, Calif.; CDL:090728-A)
000006683 Woodard, M.W.; Cockrell, K.O.; Woodard, G. (1966) Phosalone: Safety
Evaluation by Repeated Oral Administration to Rats and Dogs for
104 Weeks: Interim Report—53 Weeks. (Unpublished study re-
ceived Dec 12, 1966 under 7G0575; prepared by Woodard Research
Corp., submitted by Chipman Chemical Co., Inc., Burlingame,
Calif.; CDL:090728-B)
000006685 Woodard, M.W.; Cockrell, K.O.; Woodard, G. (1966) Phosalone: Sub-
acute Dermal Toxicity of Phosalone (R.P. 11974) for the Rabbit.
(Unpublished study received Dec 12, 1966 under 7G0575; prepared
by Woodard Research Corp., submitted by Chipman Chemical Co.,
Inc., Burlingame, Calif.; CDL:090728-D)
000006686 Woodard, M.W.; Cockrell, K.O.; Woodard, G. (1966) Phosalone: Three-
Generation Reproduction Study in the Rat: Interim Report F-0
Generation. (Unpublished study received Dec 12, 1966 under
7G0575; prepared by Woodard Research Corp., submitted by Chip-
man Chemical Co., Inc., Burlingame, Calif.; CDL:090728-E)
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Examined and Judged to be Inappropriate For Use in
Developing the Standard
000006699 Woodard, M.W.; Greenstein, E.T.; Woodard, G. (1966) Phosalone:
Safety Evaluation by Repeated Oral Administration to Rats and
Dogs for 104 Weeks: Interim Report—26 Weeks. (Unpublished
study received Dec 15, 1966 under 7G0575; prepared by Woodard
Research Corp.; submitted by Chipman Chemical Co., Inc., Bur-
lingame, Calif.; CDL:090729-O)
000006509 Woodard, M.W.; Howard, D.J.; Donoso, J.; Woodard, G. (1967) Phosa-
lone: Safety Evaluation by Repeated Oral Administration to Rats
for 103-104 Weeks. (Unpublished study received on unknown date
under 1F1155; prepared by Woodard Research Corp. for Chipman
Chemical Co., Inc., submitted by Rhodia, Inc., New Brunswick,
N.J.; CDL:098482-A)
005015525 Yaroshenko, V.I. (1974) Ekspress-metod diagnostiki otravleniya
ptshel. [Rapid method for the diagnosis of poisoning of bees.]
Veterinariya (Moscow). [Veterinary Science.] (1):98-99.
005012297 Zhuravskaya, S.A.; Bobyreva, T.V.; Gargav, V.P.; Sobchak, M.N.;
Sabirova, D.U. (1972) Izbiratel'naya toksichnost1
fosfororganicheskikh preparatov dlya vrediteley khlopchatnika i
ikh entomofagov. [Selective toxicity of organophosphorus
preparations for cotton pests and their predators.] Uzbekskii
Biologicheskii Zhurnal. [Uzbek Biological Journal.]
16(5):46-48.
005009799 Zlateva, M.; Softova, E. (1976) Changes in the spleen of albino
rats subjected to low-frequency vibration on the screen of
chronic intoxication with the pesticide "Zolon". Folia
Biologica 24(1):147-152.
005015533 Zlateva, M.; Softova, E. (1977) Gistologicheskie i
gistokhimicheskie issledovaniya miokarda belykh krys,
podvergnutykh vozdeistviyu obshei vibratsii na fone
predvaritel'noi intoksikatsii fosfororganicheskim preparatom
"zolon". [Histological and histochemical studies of the
myocardium in albino rats subjected to the action of general
vibration against a background of preliminary poisoning with
the organophosphoric preparation "Zolon".] Gigiena Truda i
Professional'nye Zabolevaniya. [Labor Hygiene and Occupational
Diseases.] 21(l):43-47.
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