PEST CONTROL IN FOOD PROCESSING PLANTS
     AND OTHER FOOD HANDLING AREAS
Hazardous Materials Advisory Committee
    Environmental Protection Agency
             February 1972

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               ENVIRONMENTAL PROTECTION AGENCY
                      WASHINGTON, D. C. 20460


                           AUG 25 1971                      of net or THE
                                                          ADMINISTRATOR
Subject:  Request  for  Hazardous  Materials Advisory
          Committee  to Review Pest Control in Food
          Processing Plants and  Other Food Handling
          Areas

To:       Hazardous  Materials Advisory Committee

I am persuaded  that  a  potentially serious situation  has
developed as  a  result  of a series of individual regulatory
actions, each one  of whifh seems to have been well  justified,
but which,  in toto,  have resulted in inadequate control
methods being available to protect foods from pest  contamina-
tion in food  handling  and processing plants.  Pest  regulatory
actions, applied on  a  use-by-use basis, have resulted  in
increasing  the  likelihood of food contamination by  pests and
vermin.  Will you  review this entire situation and  advise me
as soon as  practical as to what guidelines and policies  you
believe to  be desirable to assure a proper balance  between
the need for  pest  control and the potential hazards  from the
chemicals involved?

In considering  this  matter, I would encourage you  to consider
all routes  of exposure to the pesticides in question,  all
methods of  pest control available including all recognized
pesticide application  techniques, and any and all  other  factors
you consider  relevant.  Your suggestions may be as  innovative
as you believe  desirable.  They may distinguish between  dif-
ferent chemicals  and different application techniques.   Though
you may wish  to suggest additional research, I hope  you  will
also recommend  actions that can be taken based upon current
knowledge.

We will provide you  with reasonable staff services  and endeavor
to provide  specialized consultant services as you  deem desirable
Though I cannot set  a  firm goal for your report,  I  hope  you
will bear in  mind  the urgency of the situation and  expedite
your report accordingly.  I have stated that we expect your
report within 6 months.
William D.  Ruckelshaus
    Administra tor

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                   HAZARDOUS MATERIALS ADVISORY ^COMMITTEE
          Dr. Emil M. Mrak    Chairman
          Chancellor Emeritus
          University of California at Davis

          Dr. William J. Darby    Cochairman
          President, Nutrition Foundation
            and Chairman, Department of
            Biochemistry
          Vanderbilt University

Mr. Errett Deck
Chairman, Legislative Committee
Association of American Pesticide
  Control Officials
Washington State Department of
  Agriculture
Dr. Norton Nelson
Director, Institute of
  Environmental Medicine
New York University Medical
  Center
Dr. Leon Golberg
Scientific Director, Research Professor
  of Pathology
Institute of Experimental Pathology
  and Toxicology
Albany Medical College
Dr. Ruth Patrick
Chairman, Department of
  Limnology
Academy of Natural Sciences,
  Philadelphia
Dr. Frank Go1ley
Executive Director and Professor of
  Zoology, Institute of Ecology
University of Georgia at Athens
Dr. William R. Rothenberger
Agricultural Production
  Specialist
Frankfort, Indiana
Dr. Gordon E. Guyer
Chairman, Department of Entomology
Michigan State University
Dr. Paul E. Johnson
Executive Secretary, Food and
  Nutrition Board
National Academy of Sciences
Dr. Earl Swanson
Professor of Agricultural
  Economics
University of Illinois

Dr. Wilson K. Talley
Assistant Vice President
University of California
  Berkeley
Mr. William Murphy
President, Campbell Soup  Company,
  Camden
Dr. W. Leonard Weyl
Chief of Surgery
Northern Virginia Doctors
  Hospital
McLean, Virginia

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                             Regular Consulcants
Dr. Dale R. Lindsay
Associate Director of Medical
  Allied Health Education
Duke University
and
Dr. Caro Luhrs
Medical Advisor to the Secretary
U. S. Department of Agriculture
Mr. James G. Terrill,  Jr.
Manager, Special Projects
Environmental Systems  Department
Westinghouse Electric  Company,
  Pittsburgh
                                    Staff
          Dr. William S. Murray
          Staff Director
Mr. W. Wade Talbot
Executive Officer
                   Mrs.  Alva J.  Ware
                   Clerk-Typist
Mrs. Dorothy I. Richards
Administrative Assistant
                   Miss Carolyn L.  Osborne
                   Clerk-Stenographer
Miss Ruby D. Armstrong
Secretary

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                  CONSULTANTS
                      ON
    PEST CONTROL IN FOOD PROCESSING PLANTS
         AND OTHER FOOD HANDLING AREAS
             List of Contributors
Conveners and Members of the Hazardous Materials
                Advisory Committee
Dr. Emil M. Mrak
Chancellor Emeritus
University of California at Davis

Dr. Gordon E. Guyer
Professor and Chairman of the Department of Entomology
Michigan State University
    Consultants to the Hazardous Materials
              Advisory Committee
    Mr. Robert M. Brown
    President
    National Sanitation Foundation

    Dr. Arnold E. Denton
    Vice President, Technical Administration
    Campbell Soup Company

    Dr. Stanley P. Mayers, Jr.
    Professor of Health Care Planning
    College of Human Development
    Pennsylvania State University

    Dr. Paul W. Purdom, Sr.
    Professor of Environmental Engineering
    Drexel Institute

    Dr. Herbert F- Schoof
    Chief, Technical Development Laboratories
    Center for Disease Control

    Dr. Philip J. Spear
    Research Director
    National Pest Control Association

    Dr. Philip L. White
    Director, Department of Foods and Nutrition
    American Medical Association

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                       Resource Contacts
Mr. Samuel Billings
Pesticides Regulation Division
Environmental  Protection Agency
Mr. William F. Bower
Food Service Sanitation Branch
Food and Drug Administration
Dr. Robert L. Caswell
Pesticides Regulation Division
Environmental Protection Agency
Dr. Murray Cooper
Insect Control and Research, Inc.
Dr. Thomas H. Harris
Pesticide Tolerances Division
Environmental Protection Agency
Mr. Lessel L. Ramsey
Office of Compliance
Food and Drug Administration
                     Other Representatives
Mr. Bart
CAP, Inc.
Mr. Garth Bischoff
Mark Chemical Company
Mr. Glenn V. Brauner
National Canners Association
Mr. Vernon Cordell
National Restaurant Association
Mr. Darrell F. Jones
General Mills, Inc.
Mr. Joseph Kahn
Ritt Consolidated Industries, Inc.
Mr. Richard A. McDonald
Paper Products, Inc.
Mr. Robert Russell
Orkin Exterminating Company, Inc.
Dr. Michael P. Shinkle
Orkin Exterminating  Company,  Inc.
Dr. M. J. Sloan
Shell Chemical Company
Mr. Vern E. Walter
Bruce Terminix
Mr. Seth Wissman
Athena Corporation
                      Mr. Robert  Zeender
                      Blair Mansion  Inn

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                       POLICY AND GUIDELINES FOR
                PEST  CONTROL IN FOOD PROCESSING PLANTS
                      AND OTHER FOOD HANDLING AREAS
                               SUMMARY

          A basic need for pest control in food handling
          areas, and the attendant role of pesticides, is
          acknowledged.  However, minimization of pesticide
          use and human exposure is to be encouraged through
          local inspection and education in sanitation and
          other non-pesticide approaches.  Since neither
          assurance of absolute safety nor of harm from
          incidental exposure is normally available, a risk
          must be judged acceptable through an assessment of
          the risk-benefit equation.  Labeling should,
          therefore, reflect risks and benefits associated
          with product use.  Availability of a range of
          pesticide products should be encouraged.  Residual-
          type pesticides are particularly important; selected
          use of aerosols and vapor dispensing devices are
          appropriate under selected situations.

          Procedures for the maintenance of records of pesticide
          use in food handling establishments should be
          developed.  Dietary intake residue data are needed
          to meet legal requirements and to insure that dietary
          intake does not exceed that stipulated by existing
          food additive tolerances.
The Administrator requested the assistance of the Hazardous Materials
Advisory Committee in  the review of the subject problem for advice on
policies and guidelines to assure a balance between the need for pest
control and potential  hazards of attendant chemicals.  The following
policy and guidelines  were recommended by consultants and are hereby
endorsed by the Hazardous Materials Advisory Committee to the
Administrator.

Food processing plants and other food handling areas are exemplified
by facilities in which food, or food ingredients, are commercially
prepared for further processing or for packaging for wholesale or
retail markets.  Also  included are grocery stores, institutional
kitchens and service areas, restaurants and snack facilities, trans-
port vehicles and warehouses.

Suggested Policy

As used here, policy is considered a course of action or objective. "The
following are related  suggestions that should be considered in any

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                                -2-
re-evaluation or restructuring of policy relative to pest control
in food handling establishments.

      (a)  Pesticides must not be recognized as substitutes for
               sanitation.  The need for pesticides should be
               minimized by pest prevention through effective
               sanitation, exclusion, and non-insecticidal controls.

      (b)  There are problems of pest control that can be dealt with
               only through properly selected and applied pesticides.

      (c)  The amount of pesticides applied should be appropriate to
               minimizing human exposure via inhalation and ingestion
               as well as maximizing control of pests.

      (d)  The selected applications of residual type pesticides are
               necessary for the protection of food establishments
               from noxious pest infestations.  Alternate application
               techniques in most instances may be less desirable and
               might not provide adequate protection and in some cases
               could provide undesirable residues.

      (e)  The selected use of continuous aerosols and vapor dispensers
               such as plastic strips for slow release are appropriate
               under selected situations to prevent the annoyance by
               pests and possible food contamination by them.

      (f)  Additional food additive regulations may not be required,
               since the proposed use must be so controlled as to
               permit no greater final dietary intake than that already
               stipulated by existing tolerances.

Suggested Guidelines

Guidelines, as herein referred to, are specific approaches or steps in
the implementation of policy.

      (a)  It is suggested that increased emphasis be directed to
               education and the effective inspection and regulation
               of sanitation in food handling establishments.  Local
               agencies should be encouraged, appropriately.   This
               should include preventive sanitation in construction,
               physical maintenance and cleaning of facilities and
               equipment used in the transportation, processing, storage,
               preparation and service of food.

      (b)  Use of pesticides in food establishments should be directed
               to minimizing both the amount of pests and pesticides
               reaching food.  The choice of pesticides and their
               regulation should, therefore, be based on evaluation of
               benefit to hazard—not on the basis of toxicity of
               compounds alone I  There should be encouragement of the
               registration of the widest range of control products %>r
               pest control in food handling areas.

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                                -3-
      (c)  Pesticides should be used in dosages no greater than that
               •sufficient to eliminate the pest hazard.  Through the
               mechanism of labeling requirements, there should be
               insurance that each product describes its benefits and
               risks and that—in food handling areas—details of
               application be included (example:  cubic and square
               foot limitations and time of day to be used in
               restaurants).
      (d)
While recognizing the importance of labeling, it should not
     be a substitute for assurance of compliance.
     (e)  Representative residue data should be obtained for food
               exposed in areas treated with insecticides, either in
               response to food additive petitions or upon the
               initiative of the Pesticides Regulation Division.  Food
               additive regulations (Food, Drug and Cosmetic Act,
               Section 409) are needed in order to prescribe the safe
               conditions of use of pesticides in food handling
               establishments.  Such residue data are needed to meet
              . legal requirements and to ensure that dietary intake
               does not exceed that stipulated by existing food
               additive tolerances.

     (f)  Examples of applicable uses of continuous aerosols and vapor
               dispensers include their use in switch boxes, utility
               and rest rooms, non-food areas and in food areas where
               they will be programmed for periods of disuse.

     (g)  Procedures should be developed for the maintenance of records
               regarding all uses of pesticides in food handling
               establishments, and such information should include the
               name of materials and amount used as well as where and
               when used, and the purpose for which it was applied.

     (h)  It is believed that the "rule of reason" concept should be
               included as a component part of these guidelines:

Since it is difficult to unequivocally prove a negative (example: that
a low-level exposure does not adversely affect humans), there must be
a reasoned basis for evaluating risk versus benefit.  There comes a
time, the Supreme Court has said, when the government administrator of
a law must apply the "rule of reason."  The basis for this approach is
provided as background in the following:  Prudence counsels that we
should regard all substances foreign to man's diet, including pesticide
chemicals, as potentially poisonous and deleterious.  It is generally
recognized by scientists that a showing of safety cannot be absolute,
that the absolute safety of a pesticide chemical cannot be demonstrated.
Philosphically, the scientist is confronted with the ancient enigma of
proving the negative, an acknowledged impossibility.  Toxicological methods,
like the analytical methods of chemists, are designed to detect a
response; for the toxicologist, a discernible deleterious effect on the
animal and for the chemist, usually an instrumental reading.  Thus, a
toxicological method is inherently limited by the sensitivity of the
observation just as the analytical method is inherently limited by the

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                                -4-
sensitivity of the particular technic, including that of the instrument.
It is  likely that millions of molecules of a substance are ordinarily
required for a detectable response in either case.

In no  event can a toxicological method unequivocally demonstrate that
the effect of a pesticide chemical is zero or the analytical method
unequivocally shows that the level of such chemical is zero.  The zero
for the analytical chemist and the no-effect level (zero) for the
toxicologist may be approached ever so closely but never reached, or,
if reached, never proved in the absolute sense.

Moreover, the toxicologist recognizes that no species of animal responds,
qualitatively and quantitatively, exactly like man; and he also recognizes
that data from industrial exposure, accidents, or even short-term
controlled experiments on man are not absolutely predictive of the
long-term effects on man.  Thus, there is a risk, be it however so slight
in some cases, in translating animal data to man or even in relying on
human  data and using the common safety factors.  Obviously, prudence and
common sense dictate that human exposure to pesticide chemicals should
be minimized in order to minimize the risk and that none should be
allowed unless there is a recognizable benefit to society.

In short, the responsibile scientist cannot ignore even small amounts of
a pesticide chemical or hold that these amounts are absolutely safe;
but, on the basis of adequate data, he can make an informed judgment as
to the degree of risk and where the data warrant, he can advise that the
degree of risk is acceptable, that the pesticide usage and tolerance are
legally safe (within the meaning of the law), not absolutely safe.
Title  21 CFR*, Section 121.l(i) in the regulations sets out our legal
definition of safe.  Originally, it read:  "Safe means that there is
convincing evidence which establishes with reasonable certainty that no
harm will result from the intended use of the food additive."  In the
Federal Register of June 25, 1971, this definition was revised as follows:
"Safe means that after reviewing all of the available evidence.. .the Food
and Drug Administration can conclude that no significant risk of harm
will result when the substance is used as intended."

Those  in agencies traditionally concerned, such as the Food and Drug
Administration, are cognizant of the fact that insects and other pests
must be controlled in food processing and food service areas, not only
because of aesthetics but because of the potential for spreading disease.
* Code of Federal Regulations

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                     INFORMATION REVIEWED BY CONSULTANTS
                           ON PEST CONTROL IN FOOD
                            PROCESSING PLANTS AND
                          OTHER FOOD HANDLING AREAS
Alford, H. G.  August 19, 1968.  Notice to manufacturers, formulators,
     distributors, and registrants of economic poisons on status of residual
     type insecticide products bearing directions for use in food processing
     plants.  U. S. Department of Agriculture.  Washington, D. C.

Alford, H. G.   (undated  draft).  Notice to manufacturers, formulators,
     distributors, and registrants of economic poisons on status of residual
     type insecticide products bearing directions for use in food processing
     plants, restaurants or other areas where food is commerically prepared,
     processed or served.  Personal communication.  Environmental Protection
     Agency.  Washington, D. C.

American Can Company.  (undated).  The safer aerosol container...(rim vent
     release).  Advertisement.  Greenwich, Conn.

American Medical Association, Food Science Committee	AMA-Council on Foods
     and Nutrition and AMA-Food Industry Liaison Committee.  February 17, 1971,
     Resource conference on microbiologic safety in catered, franchised and
     vending machine foods (proceedings).  Washington, D. C.  71 p.

Appleby, W. G.  June 1,  1970.  Food additive petition no. OH2477 amendment.
     Personal communication.  Washington, D. C.

Appleby, W. G.  June 5,  1970.  Food additive petition no. OH2477.
     Personal communication.  Washington, D. C.

Athena Corporation.  (undated).  Pest-Guard, Pretty Please, bug proof shelf
     paper.  Advertisement.  Dallas.

Barlow, D. B.  October 19, 1971.  Information on measured-release aerosols.
     Personal communication.  Chevron Chemical Company.  San Francisco.

Bischoff, G. L.  December 31, 1970.  Petition no. 1H2634 for synergized
     pyrethrins in food  from the use of automatic dispensers in areas where
     food is processed or served.  CAP, Inc.  (Committee to Clarify Status of
     Automatic Pyrethrin Dispensers).  Orange, Calif.

Bischoff, G. L.  November 4, 1971.  Expansion of views on automatic pyrethrin
     dispensers.  Personal communication.  CAP, Inc.  (Committee to Clarify
     Status of Automatic Pyrethrin Dispensers).  Orange, Calif.

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                                     -2-

Bjornson, B. F., H. D. Pratt and K. S. Littig.  1956.  Control of Domestic
     Rats and Mice.  U. S. Department of Health, Education, and Welfare.
     U. S. Government Printing Office.  Washington, D. C.  Reprinted 1970
     by the Environmental Protection Agency, Office of SoLid Waste Management
     Programs.  47 p.

Bower, W. F.  February 1, 1968.  Automatic or continuous dispensing of
     insecticides in food establishments, milk houses, etc.  Personal
     communication.  Food and Drug Administration.   Cincinnati.

Bower, W. F.  April 28, 1970.  February 1, 1968 memorandum relating to
     automatic or continuous dispensing of insecticides in food establish-
     ments, milk houses, etc.  Personal communication.  Food and Drug
     Administration.  Washington, D. C.

Brauner, G. V.  October 15, 1971.  Statement presented before Hazardous
     Materials Committee of EPA.  National Canners  Assn.  Washington, D.  C.

CAP, Inc.  (Committee to Clarify Status of Automatic Pyrethrin Dispensers).
     June 15, 1970.  Brief on intermittent pyrethrin dispensers.  Unpublished.

CAP, Inc.  (Committee to Clarify Status of Automatic Pyrethrin Dispensers).
     December 28, 1970.  Compilation of reports on  intermittent pyrethrin
     dispensers.  Orange, Calif.

CAP, Inc.  (Committee to Clarify Status of Automatic Pyrethrin Dispensers).
     (undated).  Protocol, rat inhalation study.  Orange, Calif.

Cline-Buckner, Incorporated.  April 1, 1971.  Distributor /equipment and/
     prices.  Information pamphlet.  Cerritos, Calif.

Cline-Buckner, Incorporated.  (undated).  Easily programmed by you...not
     by program systems analysts.  Advertisement.  Cerritos, Calif.

Cline-Buckner, Incorporated.  (undated).  Purge II  concentrated aerosol
     insect killer.  Label.  Cerritos, Calif.

Cline-Buckner, Incorporated.  (undated).  The new Automizer automatic
     flying insect killer.  Advertisement.  Compton, Calif.

Code of Federal Regulations.  2,2-Dichlorovinyl dimethyl phosphate; tolerances
     for residues.  U. S. Government Printing Office.  Washington, D. C.
     Title 21 CFR Sec. 120.235.

Cooper, M. I.  October 15, 1971.  Summary of presentation.  Personal
     communication.  Insect Control and Research, Incorporated.
     Glenside, Pa.

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                                   - 9 -

U. S. Department of Agriculture.  September 1970.  Cockroaches, how to
     control them.  U. S. Government Printing Office.  Washington, D.  C.
     Leaflet No. 430.  Revised.  8 p.

U. S. Department of Health, Education, and Welfare, Center for Disease Control.
     March 1971.  Public health pesticides.  Pest Control.  The Harvest
     Publishing Company.

U. S. Department of Health, Education, and Welfare, Food and Drug Administration.
     November 3, 1971.  Use of automatic pyrethrin dispensers in food
     handling areas.  Field Management Directive.  Washington, D. C.

U. S. House of Representatives.  1969.  Fountain Committee hearings.   p.  88-91.
     U. S. Government Printing Office.  Washington, D.  C.

U. S. House of Representatives, Committee on Government Operations.   May  7
     and June 24, 1971.  Deficiencies in administration of Federal Insecticide,
     Fungicide, and Rodenticide Act.  Hearings.  U. S.  Government Printing
     Office.  Washington, D. C.  p. 88-91, 124-127, 138-140.

Walter, V. E.  (undated).  Pest control in food processing and food handling
     areas.  Bruce Terminix.  Harlingen, Texas.  5 p.

Wessel, R. D.  October 6, 1971.  Aerosol insecticide use in food processing
     plants.  Personal communication.  Chevron Chemical Company.  Richmond,
     Calif.

Wiseman, S.  December 2, 1969.  Petition no. 2489 for tolerance in connection
     with our bug-proof shelf paper.  Personal communication.  Dallas.

White, R. 0.  April 13, 1966.  Notice to manufacturers, formulators,
     distributors, and registrants of economic poisons  on registering
     pesticides on a zero tolerance or no residue basis.  Personal communication.
     U. S. Department of Agriculture.  Washington, D. C.

Zapp, J. A., Jr.  December 13, 1971.  Comment on protocol.  Personal
     communication.  Wilmington, Del.

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                                     -3-

Cordell, V. E. and R. R. Zeender.  October 15, 1971.  Presentation made
     to consultants on pest control in food processing plants and other
     food handling areas.  National Restaurant Association.  Chicago.
     Unpublished.  6 p.

Diechmann, W. B.  December 13, 1971.  Comments on protocol.  Personal
     communication.  Coral Gables, Fla.

Dierks, J. C.  November 3, 1971.  Misuse, abuse of the use, and toxicity of
     pesticides relative to food processing.  Personal communication.
     Omaha-Douglas County Health Department.  Omaha.

Espoy, H. M.  March 17, 1970.  Study to determine the effects on various
     food products placed in cabinets which were sprayed with common
     commercial household insecticide sprays packaged in aerosol cans.
     Unpublished.  Daylin Laboratories, Incorporated.  Los Angeles.

Espoy, H. M.  April 27, 1971.  Study to determine the effects on various
     food products placed in cabinets which were sprayed with commercial
     household insecticide sprays packaged in aerosol cans.  Unpublished.
     Daylin Laboratories, Incorporated.  Los Angeles.

Espoy, H. M.  September 13, 1971.  Study of lindane release into air
     from lindane-impregnated paper.  Unpublished.  Daylin Laboratories,
     Incorporated.  Los Angeles.

Federal Food, Drug, and Cosmetic Act, as amended.  April 1970.  Title 21
     U. S. Code.  U. S. Government Printing Office.  Washington, D. C.
     Reprint.  83 p.

Federal Register.'  February 28, 1968.  Milk, eggs, meat, and/or poultry,
     pesticide tolerances; policy statement.  Washington, D. C.  33:3438.

Federal Register.  January 13, 1970.  Shell Chemical Company, notice of
     filing of petition for food additives.  Washington, D. C.  35:440.

Federal Register.  January 21, 1970.  Athena Corporation, notice of
     filing of petition for food additives.  Washington, D. C.  35:820.

Federal Register.  June 16, 1970.  Hazelton Laboratories, Incorporated,
     notice of filing of petition for food additives.  Washington, D. C.
     35:9869.

Federal Register.  August 8, 1970.  Shell Chemical Company, denial and
     withdrawal of petition for food additive 2,2-dichlorovinyl dimethyl
     phosphate.  Washington, D. C.  35:12680.

Federal Register.  October 8, 1970.  Hazelton Laboratories, Incorporated,
     notice of withdrawal of petition for food additives.  Washington, D. C.
     35:15859.

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Federal Register.  December 9, 1970.  Committee to Clarify Status of Automatic
     Pyrethrin Dispensers, denial of petition for food additive pyrethrins in
     conjunction with N-octyl bicycloheptene dicarboximide and piperonyl
     butoxide.  Washington, D. C.  35:18687.

Federal Register.  April 6, 1971.  Committee to Clarify Status of Automatic
     Pyrethrin Dispensers, notice of filing of petition for food additives.
     Washington, D. C.  36:6540.

Federal Register.  April 16, 1971.  Athena Corporation, denial of petition
     for food additive, chlordane.  Washington, D. C.  36:7283-7284.

Federal Register.  August 13, 1971.  Rules and Regulations, Table G-I	
     continued.  Washington, D. C.  36:15103-15104.

Fine, S. D.  November 19, 1971.  Pyrethrins and automatic dispensing devices.
     Personal communication.  Food and Drug Administration.  Washington, D. C.

Fine, S. D.  November 19, 1971.  Use of automatic pesticide dispensers
     containing pyrethrins and piperonyl butoxide.  Personal communication.
     Food and Drug Administration.  Washington, D. C.

Fisher, F. E.  January 4, 1972.  Automatic pyrethrin dispensers.  Personal
     communication.  Indiana State Board of Health.  Indianapolis.

Fitzsimmons, K. R.  March 19, 1970.  Safety of No-Pest (Vapona) insecticide
     strips with regard to inhalation.  Shell Chemical Company.  Unpublished.
     New York.

Food Chemical News.  September 27, 1971.  Hearing examiner rules for
     registration of lindane vaporizers.  Louis Rothschild, Jr.
     Ed. & Pub.  Washington, D. C.

Food Chemical News.  November 8, 1971.  Judicial officer allows commercial
     use of lindane vaporizers,  p. 34-35.  Louis Rothschild, Jr.
     Ed. & Pub.  Washington, D. C.

Harris, K. L., J. F. Nicholson, L. K. Randolph and J. L. Trawick.
     January 4, 1952.  Report on -the wheat and wheat flour investigational
     program.  J. Assn. Off.  Agr. Chemists.  Feb 1952.  Condensed
     by R. K. Durham, Millers' National Federation.  Chicago.  7 p.

Harris, T. H.  May 11, 1971.  Pesticide food additive petition no. 1H2634,
     background information, and recommendation of action.  Personal
     communication.  Environmental Protection Agency.  Washington, D. C.

Harris, T. H.  May 26, 1.971.  Memorandum of conference between CAP, Inc. and
     EPA on automatic pyrethrin dispensers--food additive petition no.  OH2515.
     Personal communication.  Environmental Protection Agency.  Washington, D. C.

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                                 - 5 -

Hayes, W. J., Jr.  October 20, 1971.  Study on pyrethrin formulations.
     Personal communication.  Nashville.

Hayes, W. J., Jr.  December 2, 1971.  Comments on protocol.  Personal
     communication.  Nashville.

Holsing, G. C.  May 6, 1970.  Petition no. OH2545 for lindane as a contact
     insecticide in shelf and drawer paper.  Hazelton Laboratories Incorporated.
     Vienna, Va.

Holsing, G. C. September 3, 1970.  Withdrawal of food additive petition
     no. OH2545 without prejudice to a future filing.  Personal communication.
     Hazelton Laboratories Incorporated.  Vienna, Va.

Jones D. F.  October 19, 1971.  Points on control of food contaminating
     pests.  Personal communication.  Operative Millers Sanitation Committee.
     Minneapolis.

Jones, D. F.  November 2, 1970.  Boxcar study--1970.  Personal communication.
     Association of Operative Millers Sanitation Committee.  Minneapolis.  5.  p

Kimbrough, R. D., T. B. Gaines and W. J. Hayes, Jr.   March 1968.  Combined
     effect of DDT, pyrethrum, and piperonyl butoxide on rat liver.  Arch.
     Environ. Health  16:333-341.

Kitzke, E. D.  October 15, 1971.  Pyrethrin aerosol  formulations around
     food processing plants and restaurants.  Personal communication.
     S. C. Johnson and Son, Incorporated.  Racine, Wise.

Mark Chemical Company.  (undated).  Chemmark Midas Auto Con automatic
     control of small flying insects.  Label.  Orange, Calif.

McClure, D. A.  September 16, 1971.   Aerosol propellants--how safe?
     Tenth Annual Industry Conference, California Cosmetic Association,
     Incorporated.  Los Angeles.

McDonald, R. A.  October 15, 1971.  Remarks of Mr. Richard McDonald,  President,
     Paper Products Incorporated, October 15, 1971 to...Hazardous Materials
     Advisory Committee of the EPA.   Unpublished.  Long Beach, Calif.

McDonald, R. A.  November 29, 1971.   Further comments on pest control in food
     handling areas.  Personal communication.  Paper Products Incorporated.
     Long Beach, Calif.

McFarland, F. J.  June 1, 1970.  Memorandum of conference between Shell
     Chemical Company and FDA on amendment to food additive petition  no.
     OH2477, DDVP resin strips.  Personal communication.  Washington, D.  C.

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                                  - 6 -

Milby, T. H., A. J. Samuels and F. Ottoboni.   October 1968.   Human exposure
     to lindane; blood lindane levels as a function of exposure.   J.
     Occup. Med.  10:584-587.

Milby, T. H.  February 25, 1969.   Effects of  lindane on human health.
     Personal communication.   Berkeley, Calif.

Milby, T. H.  December 6, 1971.  Comments on  protocol.   Personal  communication.
     Berkeley, Calif.

National Pest Control Association.  May 11,  1966.   Cockroaches and their
     control.  Technical Release. Elizabeth,  N.  J.   26 p.

National Pest Control Association.  July 20,  1970.   Food plant pest control.
     Technical Release.  Elizabeth, N. J.  7  p.

National Pest Control Association (NPCA).  September 15, 1971. Schedule  A,
     NPCA insured termite warranty program and  the  following  good practice
     statement drafts on:  The use of thallium sulfate by  the PCO,  The
     use of traps for commensal rodent control  by  the PCO, The use of
     calcium cyanide as a burrow fumigant, Misting  of insecticides
     indoors, The use of dusts indoors for insect control, The use of
     insecticidal baits for insect control, The use of insecticidal
     aerosols indoors, The use of Avitrol 200 for bird management,  The
     use of Rid-A-Bird perches containing endrin on fenthion  for  management
     of pest birds, Practices to be followed  in all types  of  bird manage-
     ment, Technical release 14-71--Fleas.  Service Letter.   Elizabeth, N. J.   40

National Pest Control Association.  October 29,  1971.  Pest Control in
     food handling establishments.  Association Affairs.  Elizabeth, N. J.

National Pest Control Association.  (undated).   Good practice statements.
     Technical Release.  Elizabeth, N. J.  74 p.

National Restaurant Association and National  Pest Control  Association,
     Incorporated.  (undated).  Pest prevention. Technical bulletin.
     National Restaurant Association.  Chicago.   16 p.

O'Brien, J. E.  October 29, 1971.  Aerosols in food plants.   Personal
     communication.  San Francisco.

Paper Products Incorporated.   (undated).  No  Bugs M'Lady,  odorless shelf
     and drawer paper.  Label.  Long Beach,  Calif.

Pest Control Magazine.  May,  June, July, 1970.   Roach control in  a restaurant.
     Reprints.  The Harvest Publishing Co.  20 p.

Ramsey, L. L.  November 1, 1971.   Certain aspects  of public policy on pesticides.
     Unpublished.  Food and Drug Administration. Washington, D.  C. 8 p.

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                                  - 7 -

Rasmussen, W. A., J. A. Jensen, W. J. Stein and W. J. Hayes, Jr.
     July 1963.  Toxicological studies of DDVP for disinsection of aircraft.
     Aerospace Med.  34:593-600.

Russell, R. M.  (undated).  A summary regarding the use of residual insecticides
     for insect control in food areas,  unpublished.  Orkin Extermination
     Company.  Atlanta.

Shahied, S. I.  June 21, 1971.  Determination of lindane residues in food
     stuffs.  Unpublished.  TRW Hazelton Laboratories.  Vienna, Va.

Shell Chemical Company.  (undated).  No-Pest Strip insecticide.  Label.
     New York.

Shell Chemical Company.  (undated).  Use of insecticides in food preparation
     areas.  Unpublished.

Shell Chemical Company.  (undated).  Vapona insecticide pest strip.  Label.
     Princeton, N. J.

Shinkle, M. P.  September 21, 1971.  Primary problems in controlling pests
     in food handling areas.  Personal communication.  Orkin Exterminating
     Company.  Waukegan, 111.

Shinkle, M. P.  October 15, 1971.  Statement before the Hazardous Materials
     Advisory Committee, EPA.  Unpublished.  Orkin Exterminating Company.
     Waukegan, 111.  4 p.

Sibley, J.  June 9, 1971.  Health grading of restaurants urged.  New York
     Times.

Simmons, S. W,  November 24, 1971.  Study on pyrethrin insecticide
     dispensers.  Personal communication.  Chamblee, Ga.

Sloan, M. J.  October 15, 1971.  Comments on the use of Vapona (DDVP)
     insecticide resin strips in homes and food handling areas.  Unpublished.
     Shell Chemical Company.   San Ramon,  Calif.   7 p.

Sloan, M. J.  October 28, 1971.  Use of Vapona (DDVP) insecticide resin  strips
     in food-handling areas.  Personal communication.  "Shell Chemical Company.
     San Ramon, Calif.

Smith, C. L.  February 4, 1971.  Shell 207. Vapona insecticide resin strips,
     USDA reg. no. 201-136.  Personal communication. Washington, D. C.

TerBush, L. E.  March 22, 1971.  Food additive petition no. 1H2634.
     Personal communication.  Environmental Protection Agency.   Washington, D. C.

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                                  - 8 -

Toland, W. G.  October 6, 1971.  Aerosol insecticide use in food processing
     plants.  Personal communication.  Chevron Chemical Company.  Richmond,
     Calif.

Toland, W. G.  October 14, 1971.  Aerosols.   Personal communication.   Chevron
     Chemical Company.  San Francisco.

Upholt, W. M.  September 1,  1971.  Information for panel on pest control  in
     food handling establishments.  Personal communication.   Environmental
     Protection Agency.  Washington, D. C.

Upholt, W. M.  December 28,  1971.  Draft report on pest control  in food
     areas.  Personal communication.  Environmental Protection Agency.
     Washington, D. C.

Upholt, W. M.  (undated).  Food additive petition no. 1H2634.  Personal
     communication.  Environmental Protection Agency.  Washington, D.  C.

U. S. Environmental Protection Agency.   August 1971.  EPA asks study  of
     pesticides in food handling.  Environmental News.   Washington, D.  C.

U. S. Environmental Protection Agency.   (undated).  Brief on food additive
     petition no. 1H2634:  (automatic pyrethrin dispenser APD).
     Washington, D. C.

U. S. Environmental Protection Agency.   (undated).  Brief on food additive
     petition no. OH2477 (No-Pest Strip insecticide).  Washington, D.  C.

U. S. Environmental Protection Agency.   (undated).  Brief on food additive
     petition no. OH2489 (chlordane impregnated shelf paper).  Washington,
     D. C.

U. S. Environmental Protection Agency.   (undated).  Brief on food additive
     petition no. OH2545 (lindane impregnated shelf paper).   Washington,  D.  C.

U. S. Department of Agriculture, Agricultural Marketing Service in co-
     operation with Wisconsin Agricultural  Experiment Station, Department
     of Entomology.  Revised May 1962.  ' Insect prevention and control  in
     plant processing dry milk.  AMS-302.  12 p.

U. S. Department of Agriculture and Department of Health, Education,  and
     Welfare.  1966.  Statement for implementation of the NRC Pesticide
     Residue Committee's "Report on 'no residue* and 'zero tolerance.'"
     Washington, D. C.

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