FUNGICIDES:
An Overview of Health Effects
Information Currently Available
Special Pesticide Review Division
Office of Pesticide Programs
September 15, 1980
-------
INTRODUCTION
Fungicides are being more heavily affected by the RPAR process than any other
major class of pesticides regulated under FIFRA.
Twelve major fungicides are or will be reviewed by OPP. Nine fungicides (six
of which are EBDC's) are currently in the RPAR process and another three have
been accepted for pre-RPAR review. In addition, another major fungicide has
been referred for pre-RPAR based on oncogenicity data. There are still other
pesticides not considered major fungicides but registered for fungicidal uses
which are also in the various stages of the RPAR process. Cadi urn, sodium
pentachlorophenol, and thiophanate are some examples.
Even for the remaining fungicides identified in this paper, there is reasonable
probability that as data gaps are filled, information will indicate some or
most of them present adverse affects to man or the environment.
Attachment I lists the major fungicides addressed in this report and summarizes
the current toxicity information and regulatory status.
Attachment II summarizes this information and presents it in tabular form to
correspond to the eighteen (18) use-site categories presented in the BFSD
portion of this report. This chart can be used to assess the health problems
identified with the alternatives available for each use.
-------
ATTACHMENT 1
MAJOR FUNGICIDES USED IN AGRICULTURE
Fungicide
Toxicity and Regulatory Status
Information
1. Benomyl*
2. Cadmium
3. Captafol (Difolaton)*
4. Captan*
5. Chlorothalonil*
PD-2/3 issued on 8/22/79; mutagenicity,
teratogenicity, and reduction in
spermatogenic activity, chronic
risk criteria were exceeded; point
mutagen risk was rebutted on
insufficient evidence; New study
indicates chemical is an oncogen.
RPAR issued 10/26/77 based on
oncogenicity; mutagenicity,
teratogenicity and fetoxicity.
Accepted for pre-RPAR review on
7/14/78; data suggest chemical
meets risk criteria for mutagenicity
and teratogenicity; indicated data
gaps-oncogenicity, mutagenicity,
neurotoxicity; many existing
studies in data base done by >
IBT.
PO 1 issued 8/16/80; triggers are
oncogenicity and mutagenicity; may
have other chronic effects;
insufficient data to draw terato-
genicity conclusion; indicated
data gaps - subacute and chronic
toxicity.
Rejected for pre-RPAR review on
9/13/77; rereferred because of
recent (1978) NCI study positive
for oncogenicity; appears to be
neurotoxicity data gap; contaminant
residue (HCB) on food is a
presumed carcinogen.
-------
-2-
6. Coppers*
a. Copper naphenates
6.
b. Copper Sulfate and other
inorganic copper salts
7. 1,3 Dicloropropene
8. Dinocap (Karathane)*
9. Dodine* -
10. EBDC's
a. Amobam*
b. Mancozeb*
9.
10.
a. No adverse toxicity data
available indicative of possible
trigger for RPAR criteria;
appears to be a nunber of gaps
. in chronic data base.
b. No adverse toxicity data
available indicative of possible
trigger for RPAR criteria;
appears to be a nunber of gaps
in the chronic data base.
Accepted for pre-RPAR review
11/7/77 based on mutagenicity;
potential carcinogen.
Has a very close structural
similarity to Dinitrophenol
(DNP), a well-known catarac-
togenic agent and uncoupling
agent of the oxidative
phosphorylation of ADP to ATP
in cellular metabolism; data
gaps include the following
studies - oncogenic, mutagenic,
teratogem'c, neurotoxicity
and reproductivity; questions
on cataract formation
and margin of safety need to
be addressed.
Much available data is old;
data gaps - teratology, possible
second oncogenic study.
RPAR issued on 8/10/77;
an oncogen and teratogen,
probably on the basis of ETU,
the degradation product common
to all EBDC's.
RPAR issued on 8/10/77;
an oncogen and teratogen,
probably on the basis of
ETU, the degradation product
common to all EBDC's.
-------
-3-
c. Metiram*
d. Nabam*
e. Maneb*
f. Zaneb*
11. Fenaminosulf
12. Ferbam*
13. Folpet (Phaltan)*
14. Hexachlorobenzene (HCB)
c. RPAR issued on 8/10/77; an
oncogen and teratogen, probably on
the basis of ETU, the degradation
product common to all EBDC's.
d. RPAR issued on 8/10/77; an oncogen
and teratogen, probably on the
basis of ETU, the degradation
product common to all EBDC's.
e. RPAR issued 8/10/77; an oncogen
and teratogen, probably on basis
of ETU, the degradation product
common to all EBDC's; acutely
toxic to wildlife and aquatic
species when used on cranberries.
f. RPAR issued 8/10/77; an oncogen
and teratogen, probably on basis
of ETU, the degradation product
common to all EBDC's acutely toxic
to wildlife and aquatic species
when used on cranberries.
11. Currently non-RPAR, referred to
SPRD; potential mutagen.
12. Existing tox data is old,
incomplete and generally of
little or no value; potential
neurotoxicity problem; certain
literature "indefinite11 with |
respect to carcinogenic potential;
data daps - acute dermal and
inhalation toxicity, mutagenicity,
and dermal and eye irritation and
oncogenicity.
13. Accepted for pre-RPAR on 10/31/77
on basis of teratogenicity; other
tests indicate possible oncogen
and mutagen under some conditions;
chemical structure very much like
that of captan.
14. Accepted for pre-RPAR based on
mutagenicity, oncogenicity and
teratogenicity.
-------
-4-
15. Methyl Bromide
16. PCNB*
17. Sodium Phetachlorophenol
18. Thiophanate-Methyl
19. Thiram*
15. Referred to SPRD based on mutagenicity
data. Review of data by HEO
Indicates RPAR trigger is hit.
16. RPAR issued on 10/20/77 on basis
of meeting the oncogenicity risk
criteria; test indicate that HCB,
a contaminant of PCNB, may
induce oncogenic and reproductive
effects.
17. RPAR issued on 10/17/77; on basis
of teratogenicity and fetotoxicity.
New study indicates chemical is
an oncogen.
18. RPAR issued on 12/7/77 based on
mutagenic trigger; significant
local reduction in earthworm
populations; both triggers rebutted;
new oncogenic information received
on metabolite, MBC, which is also
present in benomyl; additional
mutagenic testing required.
19. Accepted for pre-RPAR on 11/8/77
on basis of teratogenicity;
possible neurotoxicity data gap.
The asterisked fungicides comprise considerably more than 9056 of the total
annual percentage of fungicides used in the production of food and fiber.
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON POME FRUITS (APPLES, PEARS)
A. Use: Foliar
B. Major Diseases; Scab, powdery mildew, rusts, fire blight, summer diseases,
leaf spots.
C. Major Recommended Fungicides;
I/
Fungicide
Suitability Regulatory Status
Current Toxicity
Information
RPAR
EBDC
Benomyl
Captan
1-1-1 RPAR issued;
PD 2/3 in final
draft
2-1-1 PD 2/3 issued
on 8/22/79
2-2-1 PD 1 issued on
8/16/80
Oncogen, teratogen
toxic to wildlife
Oncogen, mutagen,
teratogen
reproductive
effects, other
chronic effects
Oncogen, mutagen
PRE-RPAR
Captafol
Folpet
1-2-2
1-2-2
Pre-RPAR
Pre-RPAR
Accepted as potential
mutagen and teratogen
Accepted as potential
teratogen; possible
oncogen and mutagen
NON-RPAR
Sulfur
2-3-3
Non-RPAR
Toxicity data available
Dodine
2-2-1
Non-RPAR
No adverse toxicity
data available
-------
Funaicide
II
-2-
Suitability Regulatory Status
Current Toxicity
Information
Oinocap
Coppers
Streptomycin
Oxyteracycline
Terramycin
Dithiocarbamates
1-3-1
3-1-3
1-3-1
1-3-1
1-3-1
2-1-2
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Potential cataractogenic;
No adverse toxicity
data available
Toxicity data available
Toxicity data available
Toxicity data available
Potential neurotoxicity
problem
All suitability assignments are taken from BFSD Document presented in
in Appendix 1.
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON STONE FRUITS (PEACHES, NECTARINES,
APRICOTS, PLUMS, PRUNES, CHERRIES)
A. Use: Foliar
B. Major Diseases: Brown rot, leaf curl, shot hole, green fruit rot, russet
scab, rust, powdery mildew
C. Major Recommended Fungicides:
Fungicide
RPAR's
Benomyl
Captan
Na PCP
Suitability Regulatory Status
2-2-1 PD 2/3 issued
on 8/22/79
1-2-1 PD 1 issued
8/16/80
3-3-3 RPAR issued
10/17/77
Current Toxicity
Information
Oncogen, mutagen,
teratogen, reproductive
effects, other chronic
effects
Oncogen, mutagen
Oncogen, teratogen,
fetotoxic
PRE-RPAR
Captafol
1-2-1
Pre-RPAR
Potential mutagen,
teratogen
NON-RPAR
Coppers
Dichlone
Sulfur
3-1-3
2-2-2
2-2-3
Non-RPAR
Non-RPAR
Non-RPAR
No adverse toxicity
data available
Toxicity data available
Toxicity data available
-------
-2-
Current Toxicity
Fungicide Suitability Regulatory Status Information
Dinocap 1-3-1 Non-RPAR Potential catarac^ogenic
Dithiocarbamates 1-2-1 Non-RPAR Potential neurotoxicty
problem
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON CITRUS (ORANGES, LEMONS, GRAPEFRUIT)
A. Use: Foliar
B. Major Diseases: Brown rot gunmosis, greasy spot, roelanose,
scab
C. Major Recommended Fungicides:
Fungicide
RPAR's
Suitability Regulatory Status
Current Toxicity
Information
Benomyl
2-2-1 PD 2/3 issued
on 8/22/79
Oncogen, Mutagen,
Teratogen,
Reproductive Effects
PRE-RPAR
Captafol
1-1-1
Pre-RPAR
Accepted as potential
mutagen and teratogen
NON-RPAR
Coppers
Oil Sprays
3-1-3
2-3-3
Non-RPAR
Non-RPAR
No adverse toxicity
data available
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON TROPICAL FRUITS (BANANAS,
MANGO, PINEAPPLES, PAPAYA)
A. Use: Foliar
B. Major Diseases: Sigatoka disease of bananas, stem-end rots,
Phytophthora'blight and anthracnose of papaya, root and heart
rots.
C. Major Recommended Fungicides;
Fungicide
Suitability Regulatory Status
Current Toxicity
Information
RPAR
EBDC's
Benomyl
1-1-1
2-1-1
Captan
Thiophanate
Methyl
1-2-1
2-1-1
PD 2/3 in final
draft
PD 2/3 issued
on 8/22/79
PD 1 issued
8/16/80
Notice of
Determination
issued, continued
registration allowed.
Oncogen, teratogen,
toxic to wildlife
Oncogen, mutagen,
teratogen,
reproductive
effects, other
chronic effects
Oncogen, mutagen
Potential mutagen
and oncogen
PRE-RPAR
Captafol
Chlorothalonil
1-2-1
1-2-1
Pre-RPAR
Referred for
Pre-RPAR
Potential mutagen,
teratogen
Potential oncogen
-------
-2-
Current Toxicity
Fungicide Suitability Regulatory Status Information
NON-RPAR
Oil Sprays 2-2-2 Non-RPAR Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON SMALL FRUITS (GRAPES, STRAWBERRIES,
BLUEBERRIES, CRANBERRIES, BRAMBLES)
A. Use: Foliar and Soil Treatments
B. Major Diseases: Foliar/blueberries - bacterial canker and
mummyberry; cranberries - Guignardia blight and Lophodermiun twig
blight; grapes - powdery mildew; strawberries - powdery mildew,
leaf spot, and anthracnose; all small fruits - botrytis fruit
rots and blights. Soil/strawberries - red stele, root rots,
Verticil!ium wilts.
C. Major Recommended Fungicides:
Fungicide
FOLIAR
Suitability Regulatory Status
Current Toxicity
Information
.RPAR's
Benomyl
Captan
EBDC's
2-1-1
PD 2/3 issued
on 8/22/79
2-2-1
1-1-1
PD 1 issued
8/16/80
PD 2/3 in
final draft
Oncongen, mutagen,
teratogen, reproductive
effects, other chronic
effects
Oncogen, mutagen
Oncogen, teratogen,
toxic to wildlife
PRE-RPAR
Captafol
1-2-1
Pre-RPAR
Potential mutagen,
teratogen
NON-RPAR
Dichloran
1-3-2
Non-RPAR
Toxicity data available
-------
Fungicide
Sulfur
Coppers
Biphenyl
Oodine
Ca Cyanide
Dithiocarbamates
SOIL ..-:-.
PRE-RPAR
Methyl Bromide L-l-3
1,3-D, chloropropene 1-3-3
NON-RPAR
-2-
Suitability Regulatory Status
2-3-3 Non-RPAR
3-1-3 Non-RPAR
1-3-3
1-3-2
1-3-3
1-2-1
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Pre-RPAR
Pre-RPAR
Current Toxicity
Information
Toxicity data available
No adverse toxicity
data available
Toxicity data available
Toxicity data available
Toxicity data available
Potential neurotoxicity
problem
Potential mutagen
Potential mutagen
and oncogen
Chloropicrin
1-1-3
Non-RPAR
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON NUTS (WALNUTS, ALMONDS, PECANS,
FILBERTS)
A. Use: Foliar
Major Diseases: Brown rot, walnut blight, shot hole, bacterial
canker, scab, downy shot, zonate leaf spot, powdery mildew
Major Recommended Fungicides:
Fungicide
Suitability Regulatory Status
Current Toxicity
Information
RPAR
Benomyl -
Captan
EBDC's
Na PCP
2-2-1
1-2-1
1-2-1
3-3-3
-
PD 2/3 issued
on 8/22/79
PD 1 issued
8/16/80
PD 2/3 in
final draft
RPAR issued
10/17/77
Oncogen,. mutagen,,
teratogen, reproductive
effects, other chronic
effects
Oncogen, mutagen
Oncogen, teratogen,
toxic to wildlife
Oncogen, teratogen,
fetotoxic
NON-RPAR
Coppers
Dichlone
Triphenyltin
Hydroxide
3-1-3
2-2-2
1-1-2
Non-RPAR
Non-RPAR
Non-RPAR
No adverse toxicity
data available
Toxicity data available
Toxicity data available
-------
-2-
Fungicide
Dodine
Sulfur
Ziram
Suitability Regulatory Status
2-2-1
Non-RPAR
2-1-3 Non-RPAR
2-2-1 Non-RPAR
Current Toxicity
Information
No adverse toxicity
data available
Toxicity data available
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON SOLANACEOUS (TOMATO, POTATO,
PEPPER, EGGPLANT)
A. Use: Foliar and Fruit
B. Major Diseases: Late blight, Early blight, Anthracnose, Leaf spots, Wilts,
Bacterial spot, Fruit rots
C. Major Recommended Fungicides:
Fungicide Suitability Regulatory Status
Current Toxicity
Information
RPAR
EBDC's
Captan
1-1-1
3-2-1
PD 2/3 in Final
Draft
PD 1 issued
8/16/80
Oncogen, teratogen,
toxic to wildlife
Oncogen, mutagen
PRE-RPAR
Captafol
Chlorothalonil
Thiram
2-2-1 Pre-RPAR
1-1-1 Referred for
Pre-RPAR
2-1-1 Pre-RPAR
Potential mutagen,
teratogen
Potential oncogen
Teratogen
NON-RPAR/SUITABILITY
Coppers 3-1-3
Dithiocarfaamates 2-1-1
Dichloran 1-3-1
Non-RPAR
Non-RPAR
Non-RPAR
No adverse toxic it y
data available
Potential neurotoxicity
problem
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON LEAFY VEGETABLES (LETTUCE, SPINACH,
COLLARDS, CABBAGE, BROCCOLI, CAULIFLOWER,
CELERY, BRUSSEL SPROUTS)
A. Use: Foliar
B. Major Diseases; Leaf spots, Early blight, Late blight, Bottom rot,
Downey mildew, Blackleg
C. Major Recommended Fungicides;
Fungicide
Suitability Regulatory Status
Current Toxicity
Information
RPAR's
EBDC's
Captan
Benomyl
1-1-1
2-2-1
2-2-1
PD 2/3 in final
draft
PD 1 issued
8/16/80
PD 2/3 issued
Oncogen, teratogen,
toxic to wildlife
Oncogen, mutagen
Oncogen, mutagen,
ter atogen, reproduct ive
effects, other chronic
effects
PRE-RPAR
Chlorothalonil
1-2-1
Referred for Pre-
RPAR
Potential oncogen
NON-RPAR
Coppers
2-1-3
Non-RPAR
No adverse toxicity
data available
-------
-2-
Fungicide
Dithiocarbamates
Dichloran
Analazlne
Suitability Regulatory Status
2-1-1
Non-RPAR
1-3-1 Non-RPAR
2-3-2 Non-RPAR
Current Toxicity
Information
Potential neurotoxicity
problem
Toxicity data available
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON SOYBEANS
A. Use: Foliar
B. Major Diseases: Pod and stem rots
C. Major Recommended Fungicides;
Fungicide
RPAR's
Benomyl
Suitability Regulatory Status
2-2-1
PD 2/3 issued
on 8/22/79
Current Toxicity
Information
Oncogen, mutagen,
teratogen,
reproductive effects,
other chronic effects
NON-RPAR
Thiabendizole
Copper
2-2-1 Non-RPAR
3-1-2 Non-RPAR
Toxicity data available
No adverse toxicity
data available
Sulfur
3-1-2
Non-RPAR
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON PEANUTS
A. Use: Foliar
B. Major Diseases; Leaf spots, rust, web blotch
C. Major Recommended Fungicides;
Fungicide
RPAR's
EBDC's
Benomyl
Suitability Regulatory Status
1-1-1 PD 2/3 in final
draft
2-2-1 PD 2/3 issued
Current Toxicity
Information
Oncogen, teratogen,
toxic to wildlife
Oncogen, mutagen,
teratogen,
reproductive effects,
other chronic effects
PRE-RPAR's
Chlorothalonil
Captafol
NON-RPAR 's
Coppers
Sulfur
Triphenyltin
1-1-1- -
1-1-1
2-1-2
3-2-2
1-1-1
Referred
RPAR
' Pre-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Potential oncogen
Potential mutagen,
teratogen
Hydroxide
No adverse toxicity
data available
Toxicity data available
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON TOBACCO
A. Use: Foliar
B. Major Diseases: Blue mold
C. Major Recommended Fungicides:
Fungicide
RPAR's
Suitability Regulatory Status
Current Toxicity
Information
EBDC
1-1-1
PD 2/3 in final
draft
Oncogen, teratogen,
toxic to wildlife
NON-RPAR
Ridomil
Dithiocarbamates
1-1-1
2-1-1
Non-RPAR
Non-RPAR
Toxicity data available
Potenti al neurotoxi city
problem
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON CEREAL CROPS (WHEAT, BARLEY, OATS,
RYE)
A. Use: Foliar
B. Major Diseases: Rust
C. Major Recommended Fungicides:
Fungicide
Suitability Regulatory Status
Current Toxicity
Information
RPAR's
EBDC
1-1-1
PD 2/3 in final
draft
Oncogen, teratogen,
toxic to wildlife
NON-RPAR
Coppers
Sulfur
3-2-2
3-2-1
Non-RPAR
Non-RPAR
No adverse toxicity
data available
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON ORNAMENTALS (CUT FLOWERS, POTTED
PLANTS, BEDDING PLANTS, TREES)
A. Use: Foliage and soil treatments and plant dips
B. Major Diseases: Rust, wilts, blights, powdery mildew, root,
stem and corm rots
C. Major Recommended Fungicides;
Fungicide
RPAR's
EBDC's
Captan
Benomyl
Suitability
1-1-1
2-2-1
2-2-1
Regulatory Stat
PD 2/3 in final
draft
PD 1 issued
8/16/80
PD 2/3 issued
PCNB
1-3-1
on 8/22/79
RPAR issued
10/20/77
Current Toxicity
Information
Oncogen, teratogen,
toxic to wildlife
Oncogen, mutagen
Oncogen, mutagen,
teratogen,reproductive
effects, other chronic
effects
Oncogen, potential
reproductive effects
PRE-RPAR's
Chlorothalonil
Fenaminosulf
1-1-1 Referred for
Pre-RPAR
1-2-1 Referred for
Pre-RPAR
Potential oncogen
Potential mutagen
NON-RPAR
Coppers
3-1-3
Non-RPAR
No adverse toxicity
data available
-------
-2-
Current Toxicity
Fungicide
NON-RPAR
Streptomycin
Oxycarboxin
Dinocap
Sulfur
Dichloran
Terrazole
Suitability
1-3-1
1-3-1
1-3-1
2-1-3
2-2-1
1-3-1
Regulatory Status
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Information
Toxicity data available
Toxicity data available
Potential cataractogenic
Toxicity data available
Toxicity data available
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON TURFGRASS
A. Use: Foliar
B. Major Diseases: Dollar spot, brown patch, Helminthosporium
diseases, snow molds, pythium blight, rusts
C. Major Recommended Fungicides:
Fungicide
RPAR's
EBDC's
Benomyl
Cadi urns
PCNB
Thiophanate
Methyl
Suitability
1-2-1
2-2-1
2-3-1
2-2-2
2-2-1
Regulatory Stat
PD 2/3 in final
draft
PD 2/3 issued
on 8/22/79
PD 1 issued
10/26/77
RPAR issued
in /9O/77
lU/fcU///
Notice of
Determination
Current Toxicity
Information
issued; continued
registration allowed
Oncogen, teratogen,
toxic to wildlife
Oncogen, mutagsn,
teratogen, reproductive
effects, other chronic
effects
Oncogen, mutagen
teratogen, fetotoxic
Oncogen, potential
reproductive effects
Potential mutagen and
oncogen
PRE-RPAR
Chlorothalonil
1-1-1
Referred for Pre-
RPAR
Potential oncogen
NON-RPAR
Anilazine
2-1-1
Non-RPAR
Toxicity data available
-------
-2-
Fungiclde
Terrazole
Chloroneb
Improdione
Thiophanate-etnyl
Cycloheximide
Mercuries
Suitability Regulatory Status
Current Toxicity
Information
2-3-1
1-3-1
1-3-1
2-2-1
1-2-2
1-3-2
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Toxicity data available
Toxicity data available
Toxicity data available
Toxicity data available
Toxicity data available
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON FRUIT CROPS FOR POST HARVEST DISEASES
A. Use: Post harvest treatment
B. Major Diseases: Post harvest fruits rots
C. Major Recorranended Fungicides:
Fungicide
Suitability Regulatory Status
Current Toxicity
Information
RPAR
Benomyl
Cap tan
NON-RPAR/SUITABILITY
Thiabendazole
Bi phenyl
Na OPP
2-Aminobutane
Dichloran
Chlorine
Sulfur Dioxide
2-1-1
. 2-2-1
2-1-1
2-1-1
2-2-1
2-1-1
1-3-1
2-1-1
1-3-2
PD 2/3 iss
PD 1 issued
8/16/80
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Oncogen, mutagen
teratogen, reproductive
effects, other chronic
efects
Oncogen, mutagen
Toxicity data
Toxicity data
Toxicity data
Toxicity data
Toxicity data
Toxicity data
Toxicity data
available
available
available
available
available
available
available
-------
SUMMARY OF HEAJ.TH EFFECTS DATA FOR FUNGICIDES
USED ON VEGETABLES
A. Use; Seed and seed piece treatment
B. Major Diseases: Pre and post-harvest damping off, seed
piece rots
C. Major Recommended Fungicides;
Fungicide
Suitability Regulatory Status
Current Toxicity
Information
RPAR
Captan
EBDC's
1-1-1
1-1-1
PD 1 issued
8/16/80
PD 2/3 in
final draft
Oncogen, mutagen
Oncogen, teratogen,
toxic to wildlife
PRE-RPAR
Thiram
2-1-1
Pre-RPAR
Teratogen
NON-RPAR
Thiobendazole
Streptomycin
2-2-1
2-3-2
Non-RPAR
Non-RPAR
Toxicity data available
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USE ON FIELD CROPS (PEANUTS, COTTON, RICE
CORN, SOYBEANS, SUGAR BEETS) AND CEREAL CROPS
A. Use: Seed treatment
B. Major Diseases; Field crops - pre and post emergence damping off; Cereal
crops - smuts, seedling diseases
C. Major Recommended Fungicides;
Fungicide
Suitability Regulatory Status
Current Toxicity
Information
RPAR
PCNB
Captan
EBDC's
1-3-1
2-3-1
2-2-1
RPAR issued
10/20/77
PO 1 issued
8/16/80
PD 2/3 in
final draft
Oncogen, potential
reproductive effects
Oncogen, mutagen
i
Oncogen, teratogen,
toxic to wildlife
PRE-RPAR
Thiram 2-2-1 Pre-RPAR
>
Hexaclorobenzene 1-3-1 Pre-RPAR
Teratogen
Oncogen
NON-RPAR
Terrazole
Carboxin
Dichloran
2-3-1
2-3-1
2-3-1
Non-RPAR
Tton-RPAR
Non-RPAR
Toxicity data available
Toxicity data available
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON VEGETABLES AND PEANUTS (TOMATO,
PEPPER, EGGPLANT, CRUCIFERS, BEANS)
A. Use: Soil Treatment
B. Major Diseases: Southern blight, stem canker, black scurf, wire stem
(vegetables), southern blight (peanuts)
C. Major Recommended Fungicides and Suitability:
Fungicide
RPAR's
PCNB
EDBC's
Suitability Regulatory Status
1-2-1
3-1-1
RPAR issued
10/20/77
PD 2/3 in
Final draft
Current Toxicity
Information
Oncogen, potential
-reproductive effects
Oncogen, teratogen,
toxic to wildlife
NON-RPAR's
Carboxin
2-2-1
Non-RPAR
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON ROOT CROPS (ONION, CARROTS, BEETS,
TURNIPS)
A. Use: Foliar
8. Major Diseases: Leaf spots, Downey mildew, Neckrot, Blast
C. Major Recommended Fungicides:
Fungicide
Suitability Regulatory Status
Current Toxicity
Information
RPAR
EBDC
Captan
1-1-1 PD 2/3 in final
draft
2-2-1 PD 1 issued
8/16/80
Oncogen, teratogen,
toxic to wildlife
Oncogen, mutagen
PRE-RPAR
Chlorothalonil
1-1-1
Referred for
Pre-RPAR
Potential oncogen
NON-RPAR
Amilazine
Coppers
Dithiocarbamates
2-2-1 Non-RPAR
2-1-3 Non-RPAR
2-1-1
Non-RPAR
Toxicity data available
No adverse toxicity
data available 'V
Potential neurotoxicity
problem
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON CUCURBITS
A. Use: Foliar
B. Major Diseases: Downy mildew, Leaf Anthracnose, Gummy stem blight,
Powder mildew
C. Major Recommended Fungicides;
Fungicide
Suitability Regulatory Status
Current Toxicity
Information
RPAR
EBDC
Benomyl
PRE-RPAR
Chlorothalonil
1-1-1
2-2-1
1-1-1
PD 2/3 in final
draft
PO 2/3 issued
on 8/22/79
Referenced for
Pre-RPAR
Oncogen, teratogen
Oncogen, mutagen,
teratogen, reproductive
effects
Potential oncogen
NON-RPAR
Dinocap
Analazine
Dichloran
1-3-2 Non-RPAR
1-3-2 Non-RPAR
1-3-1 Non-RPAR
Potential cataractogen
Toxicity data available
Toxicity data available
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED SWEET CORN
A. Use: Foliar
B. Major Diseases: Helminthosporium leaf blights, Stalk and
ear rots
C. Major Recommended Fungicides:
Fungicide
Suitability Regulatory Status
Current Toxicity
Information
RPAR
EBDC
Captan
1-1-1 PD 2/3 in final
draft
2-2-1 PD 1 issued
8/16/80
Oncogen, teratogen,
toxic to wildlife
Oncogen, mutagen
PRE-RPAR
Chlorothalonil
1-2-1
Referred for
Pre-RPAR
Potential oncogen
-------
SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
USED ON BEANS AND PEAS
A. Use: Foliar
B. Major Diseases; Bacterial blights, Rust, Powdery mildew, Leaf spots,
Downey mildew, Storage
C. Major Recommended Fungicides:
Fungicide
Current Toxicity
Suitability Regulatory Status Information
RPAR
EBDC's
Benomyl
Captan
1-2-1 PD 2/3 in final
draft
2-3-1 PD 2/3 issued on
8/22/79
2-3-1 PD 1 issued
8/16/80
Oncogen, teratogen
Oncogen, mutagen,
teratogen,
reproductive effects,
other chronic effects
Oncogen, mutagen
PRE-RPAR
Chlorothanil
2-2-1 Referred for Pre-
RPAR Review
Potential oncogen
NON-RPAR
Coppers
Sulfur
Dithiocarbamates
2-1-3
Non-RPAR
3-2-3 Non-RPAR
1-2-1 Non-RPAR
No adverse toxicity
data available
Toxicity data available
Potential neurotoxity
problem
------- |