FUNGICIDES:

    An Overview of Health Effects
   Information Currently Available
Special Pesticide Review Division
  Office of Pesticide Programs

      September 15, 1980

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                                  INTRODUCTION
Fungicides are being more heavily affected by the RPAR process  than  any other
major class of pesticides regulated under FIFRA.

Twelve major fungicides are or will be reviewed by  OPP.   Nine fungicides (six
of which are EBDC's) are currently in the RPAR process and  another three have
been accepted for pre-RPAR review.  In addition, another  major  fungicide has
been referred for pre-RPAR based on oncogenicity data.  There are still  other
pesticides not considered major fungicides but registered for fungicidal  uses
which are also in the various stages of the RPAR process.   Cadi urn, sodium
pentachlorophenol, and thiophanate are some examples.

Even for the remaining fungicides identified in this paper, there is reasonable
probability that as data gaps are filled, information will  indicate  some or
most of them present adverse affects to man or the  environment.

Attachment I lists the major fungicides addressed in this report and summarizes
the current toxicity information and regulatory status.

Attachment II summarizes this information and presents it in tabular form to
correspond to the eighteen (18) use-site categories presented in the BFSD
portion of this report.  This chart can be used to  assess the health problems
identified with the alternatives available for each use.

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                                                              ATTACHMENT 1
                     MAJOR FUNGICIDES USED  IN AGRICULTURE
    Fungicide
  Toxicity and Regulatory Status
             Information
1.  Benomyl*
2.   Cadmium
3.   Captafol (Difolaton)*
4.   Captan*
5.   Chlorothalonil*
PD-2/3 issued on 8/22/79; mutagenicity,
teratogenicity, and reduction in
spermatogenic activity, chronic
risk criteria were exceeded; point
mutagen risk was rebutted on
insufficient evidence; New study
indicates chemical is an oncogen.

RPAR issued 10/26/77 based on
oncogenicity; mutagenicity,
teratogenicity and fetoxicity.

Accepted for pre-RPAR review on
7/14/78; data suggest chemical
meets risk criteria for mutagenicity
and teratogenicity; indicated data
gaps-oncogenicity, mutagenicity,
neurotoxicity; many existing
studies in data base done by     >
IBT.

PO 1 issued 8/16/80; triggers are
oncogenicity and mutagenicity; may
have other chronic effects;
insufficient data to draw terato-
genicity conclusion; indicated
data gaps - subacute and chronic
toxicity.

Rejected for pre-RPAR review on
9/13/77; rereferred because of  —
recent (1978) NCI study positive
for oncogenicity; appears to be
neurotoxicity data gap; contaminant
residue (HCB) on food is a
presumed carcinogen.

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                                      -2-
6.  Coppers*

    a.  Copper naphenates
6.
    b.  Copper Sulfate and other
        inorganic copper salts
7.  1,3 Dicloropropene
8.  Dinocap  (Karathane)*
9.  Dodine* -



10. EBDC's

    a.  Amobam*
    b.  Mancozeb*
9.
10.
a. No adverse toxicity data
   available indicative of possible
   trigger for RPAR criteria;
   appears to be a nunber of gaps
  . in chronic data base.

b. No adverse toxicity data
   available indicative of possible
   trigger for RPAR criteria;
   appears to be a nunber of gaps
   in the chronic data base.

Accepted for pre-RPAR review
11/7/77 based on mutagenicity;
potential carcinogen.

Has a very close structural
similarity to Dinitrophenol
(DNP), a well-known catarac-
togenic agent and uncoupling
agent of the oxidative
phosphorylation of ADP to ATP
in cellular metabolism; data
gaps include the following
studies - oncogenic, mutagenic,
teratogem'c, neurotoxicity
and reproductivity; questions
on cataract formation
and margin of safety need to
be addressed.

Much available data is old;
data gaps - teratology, possible
second oncogenic study.
       RPAR issued on 8/10/77;
       an oncogen and teratogen,
       probably on the basis of ETU,
       the degradation product common
       to all  EBDC's.

       RPAR issued on 8/10/77;
       an oncogen and teratogen,
       probably on the basis of
       ETU, the degradation product
       common  to all EBDC's.

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                                      -3-
    c.  Metiram*
    d.  Nabam*
    e.  Maneb*
    f.  Zaneb*
11.  Fenaminosulf


12.  Ferbam*
13. Folpet (Phaltan)*
14.  Hexachlorobenzene (HCB)
c.  RPAR issued on 8/10/77; an
    oncogen and teratogen, probably on
    the basis of ETU, the degradation
    product common to all EBDC's.

d.  RPAR issued on 8/10/77; an oncogen
    and teratogen, probably on the
    basis of ETU, the degradation
    product common to all EBDC's.

e.  RPAR issued 8/10/77; an oncogen
    and teratogen, probably on basis
    of ETU, the degradation product
    common to all EBDC's; acutely
    toxic to wildlife and aquatic
    species when used on cranberries.

f.  RPAR issued 8/10/77; an oncogen
    and teratogen, probably on basis
    of ETU, the degradation product
    common to all EBDC's acutely toxic
    to wildlife and aquatic species
    when used on cranberries.

11. Currently non-RPAR, referred to
    SPRD; potential mutagen.

12. Existing tox data is old,
    incomplete and generally of
    little or no value; potential
    neurotoxicity problem; certain
    literature "indefinite11 with   |
    respect to carcinogenic potential;
    data daps - acute dermal and
    inhalation toxicity, mutagenicity,
    and dermal and eye irritation and
    oncogenicity.

13. Accepted for pre-RPAR on 10/31/77
    on basis of teratogenicity; other
    tests indicate possible oncogen
    and mutagen under some conditions;
    chemical structure very much like
    that of captan.

14. Accepted for pre-RPAR based on
    mutagenicity, oncogenicity and
    teratogenicity.

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                                      -4-
15.  Methyl Bromide
16.  PCNB*
17. Sodium Phetachlorophenol
18. Thiophanate-Methyl
19. Thiram*
15. Referred to SPRD based on mutagenicity
    data.  Review of data by HEO
    Indicates RPAR trigger is hit.

16. RPAR issued on 10/20/77 on basis
    of meeting the oncogenicity risk
    criteria; test indicate that HCB,
    a contaminant of PCNB, may
    induce oncogenic and reproductive
    effects.

17. RPAR issued on 10/17/77; on basis
    of teratogenicity and fetotoxicity.
    New study indicates chemical is
    an oncogen.

18. RPAR issued on 12/7/77 based on
    mutagenic trigger; significant
    local reduction in earthworm
    populations; both triggers rebutted;
    new oncogenic information received
    on metabolite, MBC, which is also
    present in benomyl; additional
    mutagenic testing required.

19. Accepted for pre-RPAR on 11/8/77
    on basis of teratogenicity;
    possible neurotoxicity data gap.
   The asterisked fungicides comprise considerably more than 9056 of the total
   annual percentage of fungicides used in the production of food and fiber.

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                SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                     USED ON POME FRUITS (APPLES, PEARS)
A.   Use:  Foliar
B.   Major Diseases;  Scab, powdery mildew, rusts, fire blight, summer diseases,
     leaf spots.
C.   Major Recommended Fungicides;

                               I/
Fungicide
Suitability   Regulatory Status
                          Current Toxicity
                             Information
RPAR

EBDC



Benomyl
Captan
  1-1-1       RPAR issued;
              PD 2/3 in final
              draft

  2-1-1       PD 2/3 issued
              on 8/22/79
  2-2-1       PD 1 issued on
              8/16/80
                        Oncogen, teratogen
                        toxic to wildlife
                        Oncogen, mutagen,
                        teratogen
                        reproductive
                        effects, other
                        chronic effects

                        Oncogen, mutagen
PRE-RPAR
Captafol


Folpet
  1-2-2
  1-2-2
 Pre-RPAR
 Pre-RPAR
 Accepted as potential
 mutagen and teratogen

 Accepted as potential
 teratogen; possible
 oncogen and mutagen
NON-RPAR
Sulfur
  2-3-3
Non-RPAR
Toxicity data available
Dodine
  2-2-1
Non-RPAR
No adverse toxicity
data available

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Funaicide
                               II
                                    -2-
Suitability   Regulatory Status
                          Current Toxicity
                            Information
Oinocap
Coppers

Streptomycin
Oxyteracycline
Terramycin
Dithiocarbamates
  1-3-1
  3-1-3

  1-3-1
  1-3-1
  1-3-1
  2-1-2
Non-RPAR
Non-RPAR

Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Potential cataractogenic;
No adverse toxicity
data available
Toxicity data available
Toxicity data available
Toxicity data available
Potential neurotoxicity
problem
—   All suitability assignments are taken from BFSD Document presented  in
    in Appendix  1.

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              SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                USED ON STONE FRUITS (PEACHES, NECTARINES,
                     APRICOTS, PLUMS, PRUNES, CHERRIES)
A.   Use:  Foliar
B.   Major Diseases:  Brown rot, leaf curl, shot hole, green fruit rot, russet
     scab, rust, powdery mildew

C.   Major Recommended Fungicides:
Fungicide


RPAR's

Benomyl




Captan


Na PCP
Suitability   Regulatory Status
  2-2-1       PD 2/3 issued
              on 8/22/79
  1-2-1       PD 1 issued
              8/16/80

  3-3-3       RPAR issued
              10/17/77
                         Current Toxicity
                            Information
                       Oncogen, mutagen,
                       teratogen, reproductive
                       effects, other chronic
                       effects

                       Oncogen, mutagen
                       Oncogen, teratogen,
                       fetotoxic
PRE-RPAR
Captafol
  1-2-1
Pre-RPAR
Potential mutagen,
teratogen
NON-RPAR

Coppers


Dichlone

Sulfur
  3-1-3


  2-2-2

  2-2-3
Non-RPAR


Non-RPAR

Non-RPAR
No adverse toxicity
data available

Toxicity data available

Toxicity data available

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                                      -2-


                                                            Current Toxicity
Fungicide            Suitability   Regulatory Status           Information	


Dinocap                1-3-1       Non-RPAR               Potential catarac^ogenic

Dithiocarbamates       1-2-1       Non-RPAR               Potential neurotoxicty
                                                          problem

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                SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                 USED ON CITRUS (ORANGES, LEMONS, GRAPEFRUIT)
A.   Use:  Foliar
B.   Major Diseases:  Brown rot gunmosis, greasy spot, roelanose,
     scab

C.   Major Recommended Fungicides:
Fungicide


RPAR's
Suitability   Regulatory Status
                      Current Toxicity
                         Information
Benomyl
  2-2-1       PD 2/3 issued
              on 8/22/79
                      Oncogen, Mutagen,
                      Teratogen,
                      Reproductive Effects
PRE-RPAR
Captafol
  1-1-1
Pre-RPAR
Accepted as potential
mutagen and teratogen
NON-RPAR

Coppers


Oil Sprays
  3-1-3
  2-3-3
Non-RPAR
Non-RPAR
No adverse toxicity
data available

Toxicity data available

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                SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                     USED ON TROPICAL FRUITS (BANANAS,
                        MANGO, PINEAPPLES, PAPAYA)
A.   Use:  Foliar
B.   Major Diseases:  Sigatoka disease of bananas, stem-end rots,
     Phytophthora'blight and anthracnose of papaya, root and heart
     rots.
C.   Major Recommended Fungicides;
Fungicide
Suitability   Regulatory Status
                       Current Toxicity
                         Information
RPAR
EBDC's
Benomyl

1-1-1
2-1-1
Captan
Thiophanate
  Methyl
  1-2-1


  2-1-1
                                   PD 2/3 in final
                                   draft

                                   PD 2/3 issued
                                   on 8/22/79
PD 1 issued
8/16/80

Notice of
Determination
issued, continued
registration allowed.
Oncogen, teratogen,
toxic to wildlife

Oncogen, mutagen,
teratogen,
reproductive
effects, other
chronic effects

Oncogen, mutagen
Potential mutagen
and oncogen
PRE-RPAR
Captafol


Chlorothalonil
  1-2-1


  1-2-1
Pre-RPAR
Referred for
Pre-RPAR
Potential mutagen,
teratogen

Potential oncogen

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                                      -2-
                                                          Current Toxicity
Fungicide            Suitability   Regulatory Status        Information


NON-RPAR


Oil Sprays             2-2-2       Non-RPAR              Toxicity data available

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               SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                 USED ON SMALL FRUITS (GRAPES, STRAWBERRIES,
                    BLUEBERRIES, CRANBERRIES, BRAMBLES)
A.   Use:  Foliar and Soil Treatments
B.   Major Diseases:  Foliar/blueberries - bacterial canker and
     mummyberry; cranberries - Guignardia blight and Lophodermiun twig
     blight; grapes - powdery mildew; strawberries - powdery mildew,
     leaf spot, and anthracnose; all small fruits - botrytis fruit
     rots and blights.  Soil/strawberries - red stele, root rots,
     Verticil!ium wilts.
C.   Major Recommended Fungicides:
Fungicide


FOLIAR
                     Suitability   Regulatory Status
                                   Current Toxicity
                                     Information
.RPAR's

Benomyl




Captan


EBDC's
                       2-1-1
PD 2/3 issued
on 8/22/79
2-2-1
1-1-1
PD 1 issued
8/16/80
PD 2/3 in
final draft
                                  Oncongen, mutagen,
                                  teratogen, reproductive
                                  effects, other chronic
                                  effects

                                  Oncogen, mutagen
                                                         Oncogen, teratogen,
                                                         toxic  to wildlife
PRE-RPAR
Captafol
1-2-1
                                   Pre-RPAR
                      Potential mutagen,
                      teratogen
NON-RPAR
Dichloran
1-3-2
                                   Non-RPAR
                      Toxicity data available

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Fungicide

Sulfur
Coppers

Biphenyl
Oodine
Ca Cyanide
Dithiocarbamates

SOIL         ..-•••:••-.

PRE-RPAR
Methyl Bromide         L-l-3
1,3-D, chloropropene   1-3-3

NON-RPAR
                 -2-

Suitability   Regulatory Status

  2-3-3       Non-RPAR
  3-1-3       Non-RPAR
1-3-3
1-3-2
1-3-3
1-2-1
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
              Pre-RPAR
              Pre-RPAR
                       Current Toxicity
                         Information
                      Toxicity data available
                      No adverse toxicity
                      data available
                      Toxicity data available
                      Toxicity data available
                      Toxicity data available
                      Potential neurotoxicity
                      problem
                      Potential  mutagen
                      Potential  mutagen
                      and oncogen
Chloropicrin
  1-1-3
Non-RPAR
Toxicity data available

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                SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                    USED ON NUTS (WALNUTS, ALMONDS, PECANS,
                    FILBERTS)
A.   Use:  Foliar
     Major Diseases:  Brown rot, walnut blight, shot hole, bacterial
     canker, scab, downy shot, zonate leaf spot, powdery mildew
     Major Recommended Fungicides:
Fungicide
Suitability   Regulatory Status
                       Current Toxicity
                         Information
RPAR
Benomyl -
Captan
EBDC's
Na PCP

2-2-1
1-2-1
1-2-1
3-3-3
-
PD 2/3 issued
on 8/22/79
PD 1 issued
8/16/80
PD 2/3 in
final draft
RPAR issued
10/17/77
                                                         Oncogen,. mutagen,,
                                                         teratogen, reproductive
                                                         effects, other chronic
                                                         effects

                                                         Oncogen, mutagen
                                                         Oncogen, teratogen,
                                                         toxic to wildlife

                                                         Oncogen, teratogen,
                                                         fetotoxic
NON-RPAR
Coppers
Dichlone

Triphenyltin
Hydroxide
  3-1-3


  2-2-2

  1-1-2
Non-RPAR


Non-RPAR

Non-RPAR
No adverse toxicity
data available

Toxicity data available

Toxicity data available

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                                      -2-
Fungicide


Dodine


Sulfur

Ziram
Suitability   Regulatory Status
  2-2-1
Non-RPAR
  2-1-3       Non-RPAR

  2-2-1       Non-RPAR
                        Current Toxicity
                         Information
No adverse toxicity
data available

Toxicity data available

Toxicity data available

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                 SUMMARY OF HEALTH  EFFECTS  DATA  FOR  FUNGICIDES
                        USED ON  SOLANACEOUS (TOMATO,  POTATO,
                                  PEPPER, EGGPLANT)
A.   Use:  Foliar  and Fruit

B.   Major Diseases:  Late blight, Early blight, Anthracnose, Leaf  spots, Wilts,
     Bacterial spot, Fruit rots
C.   Major Recommended Fungicides:


Fungicide            Suitability   Regulatory Status
                                   Current Toxicity
                                     Information
RPAR

EBDC's


Captan
1-1-1


3-2-1
PD 2/3 in Final
Draft

PD 1 issued
8/16/80
Oncogen, teratogen,
toxic to wildlife

Oncogen, mutagen
PRE-RPAR


Captafol


Chlorothalonil


Thiram
2-2-1       Pre-RPAR
1-1-1       Referred for
            Pre-RPAR

2-1-1       Pre-RPAR
                      Potential mutagen,
                      teratogen

                      Potential oncogen
                      Teratogen
NON-RPAR/SUITABILITY
Coppers                3-1-3
Dithiocarfaamates       2-1-1
Dichloran              1-3-1
            Non-RPAR


            Non-RPAR


            Non-RPAR
                      No adverse toxic it y
                      data available

                      Potential neurotoxicity
                      problem

                      Toxicity data available

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                 SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                  USED ON LEAFY VEGETABLES (LETTUCE,  SPINACH,
                   COLLARDS, CABBAGE, BROCCOLI, CAULIFLOWER,
                             CELERY, BRUSSEL SPROUTS)
A.   Use:  Foliar

B.   Major Diseases;  Leaf spots, Early blight, Late blight, Bottom rot,
     Downey mildew, Blackleg

C.   Major Recommended Fungicides;
Fungicide
Suitability   Regulatory Status
                      Current Toxicity
                         Information
RPAR's
EBDC's
Captan
Benomyl
1-1-1
2-2-1
2-2-1
PD 2/3 in final
draft
PD 1 issued
8/16/80
PD 2/3 issued
                                                         Oncogen, teratogen,
                                                         toxic to wildlife

                                                         Oncogen, mutagen
                                                         Oncogen, mutagen,
                                                         ter atogen, reproduct ive
                                                         effects, other chronic
                                                         effects
PRE-RPAR
Chlorothalonil
  1-2-1
Referred for Pre-
RPAR
Potential oncogen
NON-RPAR

Coppers
  2-1-3
Non-RPAR
No adverse toxicity
data available

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                                      -2-
Fungicide

Dithiocarbamates

Dichloran
Analazlne
Suitability   Regulatory Status
  2-1-1
Non-RPAR
  1-3-1       Non-RPAR
  2-3-2       Non-RPAR
                       Current Toxicity
                         Information
Potential neurotoxicity
problem
Toxicity data available
Toxicity data available

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                SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                                USED ON SOYBEANS
A.   Use:  Foliar
B.   Major Diseases:  Pod and stem rots
C.   Major Recommended Fungicides;
Fungicide


RPAR's

Benomyl
Suitability   Regulatory Status
  2-2-1
PD 2/3 issued
on 8/22/79
                      Current Toxicity
                         Information
Oncogen, mutagen,
teratogen,
reproductive effects,
other chronic effects
NON-RPAR

Thiabendizole

Copper
  2-2-1       Non-RPAR

  3-1-2       Non-RPAR
                      Toxicity data available

                      No adverse toxicity
                      data available
Sulfur
  3-1-2
Non-RPAR
Toxicity data available

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              SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                              USED ON PEANUTS
A.   Use:  Foliar
B.   Major Diseases;  Leaf spots, rust, web blotch
C.   Major Recommended Fungicides;
Fungicide


RPAR's

EBDC's


Benomyl
Suitability   Regulatory Status
  1-1-1       PD 2/3 in final
              draft

  2-2-1       PD 2/3 issued
Current Toxicity
   Information
Oncogen, teratogen,
toxic to wildlife

Oncogen, mutagen,
teratogen,
reproductive effects,
other chronic effects
PRE-RPAR's
Chlorothalonil
Captafol
NON-RPAR 's
Coppers
Sulfur
Triphenyltin
1-1-1- -
1-1-1
2-1-2
3-2-2
1-1-1
Referred
RPAR
' Pre-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
                                                         Potential oncogen
                                                         Potential  mutagen,
                                                         teratogen
 Hydroxide
                                                         No adverse toxicity
                                                         data available

                                                         Toxicity data available

                                                         Toxicity data available

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              SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                              USED ON TOBACCO
A.   Use:  Foliar
B.   Major Diseases:  Blue mold
C.   Major Recommended Fungicides:
Fungicide


RPAR's
Suitability   Regulatory Status
                       Current Toxicity
                         Information
EBDC
  1-1-1
PD 2/3 in final
draft
Oncogen, teratogen,
toxic to wildlife
NON-RPAR
Ridomil

Dithiocarbamates
  1-1-1

  2-1-1
Non-RPAR

Non-RPAR
Toxicity data available

Potenti al neurotoxi city
problem

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                SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                 USED ON CEREAL CROPS (WHEAT, BARLEY, OATS,
                 RYE)
A.   Use:  Foliar
B.   Major Diseases:  Rust
C.   Major Recommended Fungicides:
Fungicide
Suitability   Regulatory Status
                       Current Toxicity
                         Information
RPAR's

EBDC
  1-1-1
PD 2/3 in final
draft
Oncogen, teratogen,
toxic to wildlife
NON-RPAR

Coppers


Sulfur
  3-2-2
  3-2-1
Non-RPAR
Non-RPAR
No adverse toxicity
data available

Toxicity data available

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              SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                USED ON ORNAMENTALS (CUT FLOWERS, POTTED
                     PLANTS, BEDDING PLANTS, TREES)
A.   Use:  Foliage and soil treatments and plant dips
B.   Major Diseases:  Rust, wilts, blights, powdery mildew, root,
     stem and corm rots
C.   Major Recommended Fungicides;
Fungicide
RPAR's
EBDC's
Captan
Benomyl
Suitability
1-1-1
2-2-1
2-2-1
Regulatory Stat
PD 2/3 in final
draft
PD 1 issued
8/16/80
PD 2/3 issued
PCNB
1-3-1
                                   on 8/22/79
RPAR issued
10/20/77
                                                         Current Toxicity
                                                            Information
                                                         Oncogen, teratogen,
                                                         toxic to wildlife

                                                         Oncogen, mutagen
Oncogen, mutagen,
teratogen,reproductive
effects, other chronic
effects

Oncogen, potential
reproductive effects
PRE-RPAR's

Chlorothalonil


Fenaminosulf
1-1-1       Referred for
            Pre-RPAR

1-2-1       Referred for
            Pre-RPAR
                      Potential oncogen


                      Potential mutagen
NON-RPAR

Coppers
3-1-3
Non-RPAR
No adverse toxicity
data available

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-2-
                    Current Toxicity
Fungicide
NON-RPAR
Streptomycin
Oxycarboxin
Dinocap
Sulfur
Dichloran
Terrazole
Suitability

1-3-1
1-3-1
1-3-1
2-1-3
2-2-1
1-3-1
Regulatory Status

Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Information

Toxicity data available
Toxicity data available
Potential cataractogenic
Toxicity data available
Toxicity data available
Toxicity data available

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               SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                             USED ON TURFGRASS
A.   Use:  Foliar
B.   Major Diseases:  Dollar spot, brown patch, Helminthosporium
     diseases, snow molds, pythium blight, rusts
C.   Major Recommended Fungicides:
Fungicide
RPAR's
EBDC's
Benomyl
Cadi urns
PCNB
Thiophanate
Methyl
Suitability

1-2-1
2-2-1
2-3-1
2-2-2
2-2-1
Regulatory Stat

PD 2/3 in final
draft
PD 2/3 issued
on 8/22/79
PD 1 issued
10/26/77
RPAR issued
in /9O/77
lU/fcU///
Notice of
Determination
                                                         Current Toxicity
                                                            Information
                                   issued; continued
                                   registration allowed
                                                         Oncogen, teratogen,
                                                         toxic to wildlife

                                                         Oncogen, mutagsn,
                                                         teratogen, reproductive
                                                         effects, other chronic
                                                         effects

                                                         Oncogen, mutagen—
                                                         teratogen, fetotoxic

                                                         Oncogen, potential
                                                         reproductive effects

                                                         Potential mutagen and
                                                         oncogen
PRE-RPAR

Chlorothalonil
1-1-1
Referred for Pre-
RPAR
Potential oncogen
NON-RPAR
Anilazine
2-1-1
Non-RPAR
Toxicity data available

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                                      -2-
Fungiclde

Terrazole
Chloroneb
Improdione
Thiophanate-etnyl
Cycloheximide
Mercuries
Suitability   Regulatory Status
Current Toxicity
   Information
2-3-1
1-3-1
1-3-1
2-2-1
1-2-2
1-3-2
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Toxicity data available
Toxicity data available
Toxicity data available
Toxicity data available
Toxicity data available
Toxicity data available

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                 SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                 USED ON FRUIT CROPS FOR POST HARVEST DISEASES
A.   Use:  Post harvest treatment
B.   Major Diseases: Post harvest fruits rots
C.   Major Recorranended Fungicides:
Fungicide
Suitability   Regulatory Status
Current Toxicity
   Information
RPAR
Benomyl
Cap tan
NON-RPAR/SUITABILITY
Thiabendazole
Bi phenyl
Na OPP
2-Aminobutane
Dichloran
Chlorine
Sulfur Dioxide

2-1-1
. 2-2-1
2-1-1
2-1-1
2-2-1
2-1-1
1-3-1
2-1-1
1-3-2

PD 2/3 iss
PD 1 issued
8/16/80
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
Non-RPAR
                                                         Oncogen, mutagen
                                                         teratogen, reproductive
                                                         effects, other chronic
                                                         efects
                                                         Oncogen, mutagen
                                                         Toxicity data
                                                         Toxicity data
                                                         Toxicity data
                                                         Toxicity data
                                                         Toxicity data
                                                         Toxicity data
                                                         Toxicity data
                                                  available
                                                  available
                                                  available
                                                  available
                                                  available
                                                  available
                                                  available

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                 SUMMARY OF HEAJ.TH EFFECTS DATA FOR FUNGICIDES
                              USED ON VEGETABLES
A.   Use;  Seed and seed piece treatment
B.   Major Diseases:  Pre and post-harvest damping off, seed
     piece rots
C.   Major Recommended Fungicides;
Fungicide
Suitability   Regulatory Status
                      Current Toxicity
                         Information
RPAR

Captan


EBDC's
  1-1-1
  1-1-1
PD 1 issued
8/16/80

PD 2/3 in
final draft
Oncogen, mutagen
Oncogen, teratogen,
toxic to wildlife
PRE-RPAR

Thiram
  2-1-1
Pre-RPAR
Teratogen
NON-RPAR

Thiobendazole

Streptomycin
  2-2-1

  2-3-2
Non-RPAR

Non-RPAR
Toxicity data available

Toxicity data available

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                 SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                   USE ON FIELD CROPS (PEANUTS, COTTON, RICE
                 CORN, SOYBEANS, SUGAR BEETS) AND CEREAL CROPS
A.   Use:  Seed treatment
B.   Major Diseases;  Field crops - pre and post emergence damping off; Cereal
     crops - smuts, seedling diseases
C.   Major Recommended Fungicides;
Fungicide
Suitability   Regulatory Status
                      Current Toxicity
                         Information
RPAR
PCNB
Captan
EBDC's

1-3-1
2-3-1
2-2-1

RPAR issued
10/20/77
PO 1 issued
8/16/80
PD 2/3 in
final draft

Oncogen, potential
reproductive effects
Oncogen, mutagen
i
Oncogen, teratogen,
toxic to wildlife
PRE-RPAR

Thiram                 2-2-1       Pre-RPAR
       >
Hexaclorobenzene       1-3-1       Pre-RPAR
                                    Teratogen

                                    Oncogen
NON-RPAR

Terrazole

Carboxin

Dichloran
  2-3-1

  2-3-1

  2-3-1
Non-RPAR

Tton-RPAR

Non-RPAR
Toxicity data available

Toxicity data available

Toxicity data available

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               SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                   USED ON VEGETABLES AND PEANUTS (TOMATO,
                    PEPPER, EGGPLANT, CRUCIFERS, BEANS)
A.    Use:  Soil Treatment
B.    Major Diseases:  Southern blight, stem canker, black scurf, wire stem
      (vegetables), southern blight (peanuts)
C.    Major Recommended Fungicides and Suitability:
Fungicide


RPAR's


PCNB


EDBC's
Suitability   Regulatory Status
   1-2-1
   3-1-1
RPAR issued
10/20/77

PD 2/3 in
Final draft
                      Current Toxicity
                         Information
 Oncogen,  potential
-reproductive  effects

 Oncogen,  teratogen,
 toxic  to  wildlife
NON-RPAR's
Carboxin
   2-2-1
Non-RPAR
 Toxicity data available

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              SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                USED ON ROOT CROPS (ONION, CARROTS, BEETS,
                TURNIPS)
A.   Use:  Foliar
8.   Major Diseases:  Leaf spots, Downey mildew, Neckrot, Blast
C.   Major Recommended Fungicides:
Fungicide
Suitability   Regulatory Status
                      Current Toxicity
                         Information
RPAR

EBDC


Captan
  1-1-1       PD 2/3 in final
              draft

  2-2-1       PD 1 issued
              8/16/80
                      Oncogen, teratogen,
                      toxic to wildlife

                      Oncogen, mutagen
PRE-RPAR

Chlorothalonil
  1-1-1
Referred for
Pre-RPAR
Potential oncogen
NON-RPAR

Amilazine

Coppers


Dithiocarbamates
  2-2-1       Non-RPAR

  2-1-3       Non-RPAR
  2-1-1
Non-RPAR
Toxicity data available

No adverse toxicity
data available    'V

Potential neurotoxicity
problem

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               SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                             USED ON CUCURBITS
A.   Use:  Foliar
B.   Major Diseases:  Downy mildew, Leaf Anthracnose, Gummy stem blight,
     Powder mildew
C.   Major Recommended Fungicides;
Fungicide
Suitability   Regulatory Status
                       Current Toxicity
                         Information
RPAR

EBDC


Benomyl
PRE-RPAR

Chlorothalonil
  1-1-1
  2-2-1
  1-1-1
PD 2/3 in final
draft

PO 2/3 issued
on 8/22/79
Referenced for
Pre-RPAR
Oncogen, teratogen
Oncogen, mutagen,
teratogen, reproductive
effects
Potential oncogen
NON-RPAR

Dinocap

Analazine

Dichloran
  1-3-2       Non-RPAR

  1-3-2       Non-RPAR

  1-3-1       Non-RPAR
                      Potential cataractogen

                      Toxicity data available

                      Toxicity data available

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             SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                            USED SWEET CORN
A.   Use:  Foliar
B.   Major Diseases:  Helminthosporium leaf blights, Stalk and
     ear rots
C.   Major Recommended Fungicides:
Fungicide
Suitability   Regulatory Status
                      Current Toxicity
                         Information
RPAR

EBDC


Captan
  1-1-1       PD 2/3 in final
              draft

  2-2-1       PD 1 issued
              8/16/80
                      Oncogen, teratogen,
                      toxic to wildlife

                      Oncogen, mutagen
PRE-RPAR

Chlorothalonil
  1-2-1
Referred for
Pre-RPAR
Potential oncogen

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                SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES
                            USED ON BEANS AND PEAS
A.   Use:  Foliar
B.   Major Diseases;  Bacterial blights, Rust, Powdery mildew, Leaf spots,
     Downey mildew, Storage
C.   Major Recommended Fungicides:
Fungicide
                                    Current Toxicity
Suitability   Regulatory Status        Information
RPAR

EBDC's


Benomyl




Captan
  1-2-1       PD 2/3 in final
              draft

  2-3-1       PD 2/3 issued on
              8/22/79
  2-3-1       PD 1 issued
              8/16/80
                      Oncogen, teratogen
                      Oncogen, mutagen,
                      teratogen,
                      reproductive effects,
                      other chronic effects

                      Oncogen, mutagen
PRE-RPAR
Chlorothanil
  2-2-1       Referred for Pre-
              RPAR Review
                      Potential oncogen
NON-RPAR

Coppers


Sulfur

Dithiocarbamates
  2-1-3
Non-RPAR
  3-2-3       Non-RPAR

  1-2-1       Non-RPAR
No adverse toxicity
data available

Toxicity data available

Potential neurotoxity
problem

-------