FUNGICIDES: An Overview of Health Effects Information Currently Available Special Pesticide Review Division Office of Pesticide Programs September 15, 1980 ------- INTRODUCTION Fungicides are being more heavily affected by the RPAR process than any other major class of pesticides regulated under FIFRA. Twelve major fungicides are or will be reviewed by OPP. Nine fungicides (six of which are EBDC's) are currently in the RPAR process and another three have been accepted for pre-RPAR review. In addition, another major fungicide has been referred for pre-RPAR based on oncogenicity data. There are still other pesticides not considered major fungicides but registered for fungicidal uses which are also in the various stages of the RPAR process. Cadi urn, sodium pentachlorophenol, and thiophanate are some examples. Even for the remaining fungicides identified in this paper, there is reasonable probability that as data gaps are filled, information will indicate some or most of them present adverse affects to man or the environment. Attachment I lists the major fungicides addressed in this report and summarizes the current toxicity information and regulatory status. Attachment II summarizes this information and presents it in tabular form to correspond to the eighteen (18) use-site categories presented in the BFSD portion of this report. This chart can be used to assess the health problems identified with the alternatives available for each use. ------- ATTACHMENT 1 MAJOR FUNGICIDES USED IN AGRICULTURE Fungicide Toxicity and Regulatory Status Information 1. Benomyl* 2. Cadmium 3. Captafol (Difolaton)* 4. Captan* 5. Chlorothalonil* PD-2/3 issued on 8/22/79; mutagenicity, teratogenicity, and reduction in spermatogenic activity, chronic risk criteria were exceeded; point mutagen risk was rebutted on insufficient evidence; New study indicates chemical is an oncogen. RPAR issued 10/26/77 based on oncogenicity; mutagenicity, teratogenicity and fetoxicity. Accepted for pre-RPAR review on 7/14/78; data suggest chemical meets risk criteria for mutagenicity and teratogenicity; indicated data gaps-oncogenicity, mutagenicity, neurotoxicity; many existing studies in data base done by > IBT. PO 1 issued 8/16/80; triggers are oncogenicity and mutagenicity; may have other chronic effects; insufficient data to draw terato- genicity conclusion; indicated data gaps - subacute and chronic toxicity. Rejected for pre-RPAR review on 9/13/77; rereferred because of recent (1978) NCI study positive for oncogenicity; appears to be neurotoxicity data gap; contaminant residue (HCB) on food is a presumed carcinogen. ------- -2- 6. Coppers* a. Copper naphenates 6. b. Copper Sulfate and other inorganic copper salts 7. 1,3 Dicloropropene 8. Dinocap (Karathane)* 9. Dodine* - 10. EBDC's a. Amobam* b. Mancozeb* 9. 10. a. No adverse toxicity data available indicative of possible trigger for RPAR criteria; appears to be a nunber of gaps . in chronic data base. b. No adverse toxicity data available indicative of possible trigger for RPAR criteria; appears to be a nunber of gaps in the chronic data base. Accepted for pre-RPAR review 11/7/77 based on mutagenicity; potential carcinogen. Has a very close structural similarity to Dinitrophenol (DNP), a well-known catarac- togenic agent and uncoupling agent of the oxidative phosphorylation of ADP to ATP in cellular metabolism; data gaps include the following studies - oncogenic, mutagenic, teratogem'c, neurotoxicity and reproductivity; questions on cataract formation and margin of safety need to be addressed. Much available data is old; data gaps - teratology, possible second oncogenic study. RPAR issued on 8/10/77; an oncogen and teratogen, probably on the basis of ETU, the degradation product common to all EBDC's. RPAR issued on 8/10/77; an oncogen and teratogen, probably on the basis of ETU, the degradation product common to all EBDC's. ------- -3- c. Metiram* d. Nabam* e. Maneb* f. Zaneb* 11. Fenaminosulf 12. Ferbam* 13. Folpet (Phaltan)* 14. Hexachlorobenzene (HCB) c. RPAR issued on 8/10/77; an oncogen and teratogen, probably on the basis of ETU, the degradation product common to all EBDC's. d. RPAR issued on 8/10/77; an oncogen and teratogen, probably on the basis of ETU, the degradation product common to all EBDC's. e. RPAR issued 8/10/77; an oncogen and teratogen, probably on basis of ETU, the degradation product common to all EBDC's; acutely toxic to wildlife and aquatic species when used on cranberries. f. RPAR issued 8/10/77; an oncogen and teratogen, probably on basis of ETU, the degradation product common to all EBDC's acutely toxic to wildlife and aquatic species when used on cranberries. 11. Currently non-RPAR, referred to SPRD; potential mutagen. 12. Existing tox data is old, incomplete and generally of little or no value; potential neurotoxicity problem; certain literature "indefinite11 with | respect to carcinogenic potential; data daps - acute dermal and inhalation toxicity, mutagenicity, and dermal and eye irritation and oncogenicity. 13. Accepted for pre-RPAR on 10/31/77 on basis of teratogenicity; other tests indicate possible oncogen and mutagen under some conditions; chemical structure very much like that of captan. 14. Accepted for pre-RPAR based on mutagenicity, oncogenicity and teratogenicity. ------- -4- 15. Methyl Bromide 16. PCNB* 17. Sodium Phetachlorophenol 18. Thiophanate-Methyl 19. Thiram* 15. Referred to SPRD based on mutagenicity data. Review of data by HEO Indicates RPAR trigger is hit. 16. RPAR issued on 10/20/77 on basis of meeting the oncogenicity risk criteria; test indicate that HCB, a contaminant of PCNB, may induce oncogenic and reproductive effects. 17. RPAR issued on 10/17/77; on basis of teratogenicity and fetotoxicity. New study indicates chemical is an oncogen. 18. RPAR issued on 12/7/77 based on mutagenic trigger; significant local reduction in earthworm populations; both triggers rebutted; new oncogenic information received on metabolite, MBC, which is also present in benomyl; additional mutagenic testing required. 19. Accepted for pre-RPAR on 11/8/77 on basis of teratogenicity; possible neurotoxicity data gap. The asterisked fungicides comprise considerably more than 9056 of the total annual percentage of fungicides used in the production of food and fiber. ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON POME FRUITS (APPLES, PEARS) A. Use: Foliar B. Major Diseases; Scab, powdery mildew, rusts, fire blight, summer diseases, leaf spots. C. Major Recommended Fungicides; I/ Fungicide Suitability Regulatory Status Current Toxicity Information RPAR EBDC Benomyl Captan 1-1-1 RPAR issued; PD 2/3 in final draft 2-1-1 PD 2/3 issued on 8/22/79 2-2-1 PD 1 issued on 8/16/80 Oncogen, teratogen toxic to wildlife Oncogen, mutagen, teratogen reproductive effects, other chronic effects Oncogen, mutagen PRE-RPAR Captafol Folpet 1-2-2 1-2-2 Pre-RPAR Pre-RPAR Accepted as potential mutagen and teratogen Accepted as potential teratogen; possible oncogen and mutagen NON-RPAR Sulfur 2-3-3 Non-RPAR Toxicity data available Dodine 2-2-1 Non-RPAR No adverse toxicity data available ------- Funaicide II -2- Suitability Regulatory Status Current Toxicity Information Oinocap Coppers Streptomycin Oxyteracycline Terramycin Dithiocarbamates 1-3-1 3-1-3 1-3-1 1-3-1 1-3-1 2-1-2 Non-RPAR Non-RPAR Non-RPAR Non-RPAR Non-RPAR Non-RPAR Potential cataractogenic; No adverse toxicity data available Toxicity data available Toxicity data available Toxicity data available Potential neurotoxicity problem All suitability assignments are taken from BFSD Document presented in in Appendix 1. ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON STONE FRUITS (PEACHES, NECTARINES, APRICOTS, PLUMS, PRUNES, CHERRIES) A. Use: Foliar B. Major Diseases: Brown rot, leaf curl, shot hole, green fruit rot, russet scab, rust, powdery mildew C. Major Recommended Fungicides: Fungicide RPAR's Benomyl Captan Na PCP Suitability Regulatory Status 2-2-1 PD 2/3 issued on 8/22/79 1-2-1 PD 1 issued 8/16/80 3-3-3 RPAR issued 10/17/77 Current Toxicity Information Oncogen, mutagen, teratogen, reproductive effects, other chronic effects Oncogen, mutagen Oncogen, teratogen, fetotoxic PRE-RPAR Captafol 1-2-1 Pre-RPAR Potential mutagen, teratogen NON-RPAR Coppers Dichlone Sulfur 3-1-3 2-2-2 2-2-3 Non-RPAR Non-RPAR Non-RPAR No adverse toxicity data available Toxicity data available Toxicity data available ------- -2- Current Toxicity Fungicide Suitability Regulatory Status Information Dinocap 1-3-1 Non-RPAR Potential catarac^ogenic Dithiocarbamates 1-2-1 Non-RPAR Potential neurotoxicty problem ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON CITRUS (ORANGES, LEMONS, GRAPEFRUIT) A. Use: Foliar B. Major Diseases: Brown rot gunmosis, greasy spot, roelanose, scab C. Major Recommended Fungicides: Fungicide RPAR's Suitability Regulatory Status Current Toxicity Information Benomyl 2-2-1 PD 2/3 issued on 8/22/79 Oncogen, Mutagen, Teratogen, Reproductive Effects PRE-RPAR Captafol 1-1-1 Pre-RPAR Accepted as potential mutagen and teratogen NON-RPAR Coppers Oil Sprays 3-1-3 2-3-3 Non-RPAR Non-RPAR No adverse toxicity data available Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON TROPICAL FRUITS (BANANAS, MANGO, PINEAPPLES, PAPAYA) A. Use: Foliar B. Major Diseases: Sigatoka disease of bananas, stem-end rots, Phytophthora'blight and anthracnose of papaya, root and heart rots. C. Major Recommended Fungicides; Fungicide Suitability Regulatory Status Current Toxicity Information RPAR EBDC's Benomyl 1-1-1 2-1-1 Captan Thiophanate Methyl 1-2-1 2-1-1 PD 2/3 in final draft PD 2/3 issued on 8/22/79 PD 1 issued 8/16/80 Notice of Determination issued, continued registration allowed. Oncogen, teratogen, toxic to wildlife Oncogen, mutagen, teratogen, reproductive effects, other chronic effects Oncogen, mutagen Potential mutagen and oncogen PRE-RPAR Captafol Chlorothalonil 1-2-1 1-2-1 Pre-RPAR Referred for Pre-RPAR Potential mutagen, teratogen Potential oncogen ------- -2- Current Toxicity Fungicide Suitability Regulatory Status Information NON-RPAR Oil Sprays 2-2-2 Non-RPAR Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON SMALL FRUITS (GRAPES, STRAWBERRIES, BLUEBERRIES, CRANBERRIES, BRAMBLES) A. Use: Foliar and Soil Treatments B. Major Diseases: Foliar/blueberries - bacterial canker and mummyberry; cranberries - Guignardia blight and Lophodermiun twig blight; grapes - powdery mildew; strawberries - powdery mildew, leaf spot, and anthracnose; all small fruits - botrytis fruit rots and blights. Soil/strawberries - red stele, root rots, Verticil!ium wilts. C. Major Recommended Fungicides: Fungicide FOLIAR Suitability Regulatory Status Current Toxicity Information .RPAR's Benomyl Captan EBDC's 2-1-1 PD 2/3 issued on 8/22/79 2-2-1 1-1-1 PD 1 issued 8/16/80 PD 2/3 in final draft Oncongen, mutagen, teratogen, reproductive effects, other chronic effects Oncogen, mutagen Oncogen, teratogen, toxic to wildlife PRE-RPAR Captafol 1-2-1 Pre-RPAR Potential mutagen, teratogen NON-RPAR Dichloran 1-3-2 Non-RPAR Toxicity data available ------- Fungicide Sulfur Coppers Biphenyl Oodine Ca Cyanide Dithiocarbamates SOIL ..-:-. PRE-RPAR Methyl Bromide L-l-3 1,3-D, chloropropene 1-3-3 NON-RPAR -2- Suitability Regulatory Status 2-3-3 Non-RPAR 3-1-3 Non-RPAR 1-3-3 1-3-2 1-3-3 1-2-1 Non-RPAR Non-RPAR Non-RPAR Non-RPAR Pre-RPAR Pre-RPAR Current Toxicity Information Toxicity data available No adverse toxicity data available Toxicity data available Toxicity data available Toxicity data available Potential neurotoxicity problem Potential mutagen Potential mutagen and oncogen Chloropicrin 1-1-3 Non-RPAR Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON NUTS (WALNUTS, ALMONDS, PECANS, FILBERTS) A. Use: Foliar Major Diseases: Brown rot, walnut blight, shot hole, bacterial canker, scab, downy shot, zonate leaf spot, powdery mildew Major Recommended Fungicides: Fungicide Suitability Regulatory Status Current Toxicity Information RPAR Benomyl - Captan EBDC's Na PCP 2-2-1 1-2-1 1-2-1 3-3-3 - PD 2/3 issued on 8/22/79 PD 1 issued 8/16/80 PD 2/3 in final draft RPAR issued 10/17/77 Oncogen,. mutagen,, teratogen, reproductive effects, other chronic effects Oncogen, mutagen Oncogen, teratogen, toxic to wildlife Oncogen, teratogen, fetotoxic NON-RPAR Coppers Dichlone Triphenyltin Hydroxide 3-1-3 2-2-2 1-1-2 Non-RPAR Non-RPAR Non-RPAR No adverse toxicity data available Toxicity data available Toxicity data available ------- -2- Fungicide Dodine Sulfur Ziram Suitability Regulatory Status 2-2-1 Non-RPAR 2-1-3 Non-RPAR 2-2-1 Non-RPAR Current Toxicity Information No adverse toxicity data available Toxicity data available Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON SOLANACEOUS (TOMATO, POTATO, PEPPER, EGGPLANT) A. Use: Foliar and Fruit B. Major Diseases: Late blight, Early blight, Anthracnose, Leaf spots, Wilts, Bacterial spot, Fruit rots C. Major Recommended Fungicides: Fungicide Suitability Regulatory Status Current Toxicity Information RPAR EBDC's Captan 1-1-1 3-2-1 PD 2/3 in Final Draft PD 1 issued 8/16/80 Oncogen, teratogen, toxic to wildlife Oncogen, mutagen PRE-RPAR Captafol Chlorothalonil Thiram 2-2-1 Pre-RPAR 1-1-1 Referred for Pre-RPAR 2-1-1 Pre-RPAR Potential mutagen, teratogen Potential oncogen Teratogen NON-RPAR/SUITABILITY Coppers 3-1-3 Dithiocarfaamates 2-1-1 Dichloran 1-3-1 Non-RPAR Non-RPAR Non-RPAR No adverse toxic it y data available Potential neurotoxicity problem Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON LEAFY VEGETABLES (LETTUCE, SPINACH, COLLARDS, CABBAGE, BROCCOLI, CAULIFLOWER, CELERY, BRUSSEL SPROUTS) A. Use: Foliar B. Major Diseases; Leaf spots, Early blight, Late blight, Bottom rot, Downey mildew, Blackleg C. Major Recommended Fungicides; Fungicide Suitability Regulatory Status Current Toxicity Information RPAR's EBDC's Captan Benomyl 1-1-1 2-2-1 2-2-1 PD 2/3 in final draft PD 1 issued 8/16/80 PD 2/3 issued Oncogen, teratogen, toxic to wildlife Oncogen, mutagen Oncogen, mutagen, ter atogen, reproduct ive effects, other chronic effects PRE-RPAR Chlorothalonil 1-2-1 Referred for Pre- RPAR Potential oncogen NON-RPAR Coppers 2-1-3 Non-RPAR No adverse toxicity data available ------- -2- Fungicide Dithiocarbamates Dichloran Analazlne Suitability Regulatory Status 2-1-1 Non-RPAR 1-3-1 Non-RPAR 2-3-2 Non-RPAR Current Toxicity Information Potential neurotoxicity problem Toxicity data available Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON SOYBEANS A. Use: Foliar B. Major Diseases: Pod and stem rots C. Major Recommended Fungicides; Fungicide RPAR's Benomyl Suitability Regulatory Status 2-2-1 PD 2/3 issued on 8/22/79 Current Toxicity Information Oncogen, mutagen, teratogen, reproductive effects, other chronic effects NON-RPAR Thiabendizole Copper 2-2-1 Non-RPAR 3-1-2 Non-RPAR Toxicity data available No adverse toxicity data available Sulfur 3-1-2 Non-RPAR Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON PEANUTS A. Use: Foliar B. Major Diseases; Leaf spots, rust, web blotch C. Major Recommended Fungicides; Fungicide RPAR's EBDC's Benomyl Suitability Regulatory Status 1-1-1 PD 2/3 in final draft 2-2-1 PD 2/3 issued Current Toxicity Information Oncogen, teratogen, toxic to wildlife Oncogen, mutagen, teratogen, reproductive effects, other chronic effects PRE-RPAR's Chlorothalonil Captafol NON-RPAR 's Coppers Sulfur Triphenyltin 1-1-1- - 1-1-1 2-1-2 3-2-2 1-1-1 Referred RPAR ' Pre-RPAR Non-RPAR Non-RPAR Non-RPAR Potential oncogen Potential mutagen, teratogen Hydroxide No adverse toxicity data available Toxicity data available Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON TOBACCO A. Use: Foliar B. Major Diseases: Blue mold C. Major Recommended Fungicides: Fungicide RPAR's Suitability Regulatory Status Current Toxicity Information EBDC 1-1-1 PD 2/3 in final draft Oncogen, teratogen, toxic to wildlife NON-RPAR Ridomil Dithiocarbamates 1-1-1 2-1-1 Non-RPAR Non-RPAR Toxicity data available Potenti al neurotoxi city problem ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON CEREAL CROPS (WHEAT, BARLEY, OATS, RYE) A. Use: Foliar B. Major Diseases: Rust C. Major Recommended Fungicides: Fungicide Suitability Regulatory Status Current Toxicity Information RPAR's EBDC 1-1-1 PD 2/3 in final draft Oncogen, teratogen, toxic to wildlife NON-RPAR Coppers Sulfur 3-2-2 3-2-1 Non-RPAR Non-RPAR No adverse toxicity data available Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON ORNAMENTALS (CUT FLOWERS, POTTED PLANTS, BEDDING PLANTS, TREES) A. Use: Foliage and soil treatments and plant dips B. Major Diseases: Rust, wilts, blights, powdery mildew, root, stem and corm rots C. Major Recommended Fungicides; Fungicide RPAR's EBDC's Captan Benomyl Suitability 1-1-1 2-2-1 2-2-1 Regulatory Stat PD 2/3 in final draft PD 1 issued 8/16/80 PD 2/3 issued PCNB 1-3-1 on 8/22/79 RPAR issued 10/20/77 Current Toxicity Information Oncogen, teratogen, toxic to wildlife Oncogen, mutagen Oncogen, mutagen, teratogen,reproductive effects, other chronic effects Oncogen, potential reproductive effects PRE-RPAR's Chlorothalonil Fenaminosulf 1-1-1 Referred for Pre-RPAR 1-2-1 Referred for Pre-RPAR Potential oncogen Potential mutagen NON-RPAR Coppers 3-1-3 Non-RPAR No adverse toxicity data available ------- -2- Current Toxicity Fungicide NON-RPAR Streptomycin Oxycarboxin Dinocap Sulfur Dichloran Terrazole Suitability 1-3-1 1-3-1 1-3-1 2-1-3 2-2-1 1-3-1 Regulatory Status Non-RPAR Non-RPAR Non-RPAR Non-RPAR Non-RPAR Non-RPAR Information Toxicity data available Toxicity data available Potential cataractogenic Toxicity data available Toxicity data available Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON TURFGRASS A. Use: Foliar B. Major Diseases: Dollar spot, brown patch, Helminthosporium diseases, snow molds, pythium blight, rusts C. Major Recommended Fungicides: Fungicide RPAR's EBDC's Benomyl Cadi urns PCNB Thiophanate Methyl Suitability 1-2-1 2-2-1 2-3-1 2-2-2 2-2-1 Regulatory Stat PD 2/3 in final draft PD 2/3 issued on 8/22/79 PD 1 issued 10/26/77 RPAR issued in /9O/77 lU/fcU/// Notice of Determination Current Toxicity Information issued; continued registration allowed Oncogen, teratogen, toxic to wildlife Oncogen, mutagsn, teratogen, reproductive effects, other chronic effects Oncogen, mutagen teratogen, fetotoxic Oncogen, potential reproductive effects Potential mutagen and oncogen PRE-RPAR Chlorothalonil 1-1-1 Referred for Pre- RPAR Potential oncogen NON-RPAR Anilazine 2-1-1 Non-RPAR Toxicity data available ------- -2- Fungiclde Terrazole Chloroneb Improdione Thiophanate-etnyl Cycloheximide Mercuries Suitability Regulatory Status Current Toxicity Information 2-3-1 1-3-1 1-3-1 2-2-1 1-2-2 1-3-2 Non-RPAR Non-RPAR Non-RPAR Non-RPAR Non-RPAR Non-RPAR Toxicity data available Toxicity data available Toxicity data available Toxicity data available Toxicity data available Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON FRUIT CROPS FOR POST HARVEST DISEASES A. Use: Post harvest treatment B. Major Diseases: Post harvest fruits rots C. Major Recorranended Fungicides: Fungicide Suitability Regulatory Status Current Toxicity Information RPAR Benomyl Cap tan NON-RPAR/SUITABILITY Thiabendazole Bi phenyl Na OPP 2-Aminobutane Dichloran Chlorine Sulfur Dioxide 2-1-1 . 2-2-1 2-1-1 2-1-1 2-2-1 2-1-1 1-3-1 2-1-1 1-3-2 PD 2/3 iss PD 1 issued 8/16/80 Non-RPAR Non-RPAR Non-RPAR Non-RPAR Non-RPAR Non-RPAR Non-RPAR Oncogen, mutagen teratogen, reproductive effects, other chronic efects Oncogen, mutagen Toxicity data Toxicity data Toxicity data Toxicity data Toxicity data Toxicity data Toxicity data available available available available available available available ------- SUMMARY OF HEAJ.TH EFFECTS DATA FOR FUNGICIDES USED ON VEGETABLES A. Use; Seed and seed piece treatment B. Major Diseases: Pre and post-harvest damping off, seed piece rots C. Major Recommended Fungicides; Fungicide Suitability Regulatory Status Current Toxicity Information RPAR Captan EBDC's 1-1-1 1-1-1 PD 1 issued 8/16/80 PD 2/3 in final draft Oncogen, mutagen Oncogen, teratogen, toxic to wildlife PRE-RPAR Thiram 2-1-1 Pre-RPAR Teratogen NON-RPAR Thiobendazole Streptomycin 2-2-1 2-3-2 Non-RPAR Non-RPAR Toxicity data available Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USE ON FIELD CROPS (PEANUTS, COTTON, RICE CORN, SOYBEANS, SUGAR BEETS) AND CEREAL CROPS A. Use: Seed treatment B. Major Diseases; Field crops - pre and post emergence damping off; Cereal crops - smuts, seedling diseases C. Major Recommended Fungicides; Fungicide Suitability Regulatory Status Current Toxicity Information RPAR PCNB Captan EBDC's 1-3-1 2-3-1 2-2-1 RPAR issued 10/20/77 PO 1 issued 8/16/80 PD 2/3 in final draft Oncogen, potential reproductive effects Oncogen, mutagen i Oncogen, teratogen, toxic to wildlife PRE-RPAR Thiram 2-2-1 Pre-RPAR > Hexaclorobenzene 1-3-1 Pre-RPAR Teratogen Oncogen NON-RPAR Terrazole Carboxin Dichloran 2-3-1 2-3-1 2-3-1 Non-RPAR Tton-RPAR Non-RPAR Toxicity data available Toxicity data available Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON VEGETABLES AND PEANUTS (TOMATO, PEPPER, EGGPLANT, CRUCIFERS, BEANS) A. Use: Soil Treatment B. Major Diseases: Southern blight, stem canker, black scurf, wire stem (vegetables), southern blight (peanuts) C. Major Recommended Fungicides and Suitability: Fungicide RPAR's PCNB EDBC's Suitability Regulatory Status 1-2-1 3-1-1 RPAR issued 10/20/77 PD 2/3 in Final draft Current Toxicity Information Oncogen, potential -reproductive effects Oncogen, teratogen, toxic to wildlife NON-RPAR's Carboxin 2-2-1 Non-RPAR Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON ROOT CROPS (ONION, CARROTS, BEETS, TURNIPS) A. Use: Foliar 8. Major Diseases: Leaf spots, Downey mildew, Neckrot, Blast C. Major Recommended Fungicides: Fungicide Suitability Regulatory Status Current Toxicity Information RPAR EBDC Captan 1-1-1 PD 2/3 in final draft 2-2-1 PD 1 issued 8/16/80 Oncogen, teratogen, toxic to wildlife Oncogen, mutagen PRE-RPAR Chlorothalonil 1-1-1 Referred for Pre-RPAR Potential oncogen NON-RPAR Amilazine Coppers Dithiocarbamates 2-2-1 Non-RPAR 2-1-3 Non-RPAR 2-1-1 Non-RPAR Toxicity data available No adverse toxicity data available 'V Potential neurotoxicity problem ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON CUCURBITS A. Use: Foliar B. Major Diseases: Downy mildew, Leaf Anthracnose, Gummy stem blight, Powder mildew C. Major Recommended Fungicides; Fungicide Suitability Regulatory Status Current Toxicity Information RPAR EBDC Benomyl PRE-RPAR Chlorothalonil 1-1-1 2-2-1 1-1-1 PD 2/3 in final draft PO 2/3 issued on 8/22/79 Referenced for Pre-RPAR Oncogen, teratogen Oncogen, mutagen, teratogen, reproductive effects Potential oncogen NON-RPAR Dinocap Analazine Dichloran 1-3-2 Non-RPAR 1-3-2 Non-RPAR 1-3-1 Non-RPAR Potential cataractogen Toxicity data available Toxicity data available ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED SWEET CORN A. Use: Foliar B. Major Diseases: Helminthosporium leaf blights, Stalk and ear rots C. Major Recommended Fungicides: Fungicide Suitability Regulatory Status Current Toxicity Information RPAR EBDC Captan 1-1-1 PD 2/3 in final draft 2-2-1 PD 1 issued 8/16/80 Oncogen, teratogen, toxic to wildlife Oncogen, mutagen PRE-RPAR Chlorothalonil 1-2-1 Referred for Pre-RPAR Potential oncogen ------- SUMMARY OF HEALTH EFFECTS DATA FOR FUNGICIDES USED ON BEANS AND PEAS A. Use: Foliar B. Major Diseases; Bacterial blights, Rust, Powdery mildew, Leaf spots, Downey mildew, Storage C. Major Recommended Fungicides: Fungicide Current Toxicity Suitability Regulatory Status Information RPAR EBDC's Benomyl Captan 1-2-1 PD 2/3 in final draft 2-3-1 PD 2/3 issued on 8/22/79 2-3-1 PD 1 issued 8/16/80 Oncogen, teratogen Oncogen, mutagen, teratogen, reproductive effects, other chronic effects Oncogen, mutagen PRE-RPAR Chlorothanil 2-2-1 Referred for Pre- RPAR Review Potential oncogen NON-RPAR Coppers Sulfur Dithiocarbamates 2-1-3 Non-RPAR 3-2-3 Non-RPAR 1-2-1 Non-RPAR No adverse toxicity data available Toxicity data available Potential neurotoxity problem ------- |