United States
Environmental Protection
Agency
Environmental Monitoring
Systems Laboratory
P.O. Box 93478
Las Vegas NV 89193-3478
EPA 600/8-91/045
July 1991
Research and Development
xvEPA
Selection of
Adduct-Forming
Chemicals for Human
Monitoring Studies
0888mGR91EAO-2
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SELECTION OF ADDDCT-FORMING CHEMICALS
FOR HUMAN MONITORING STUDIES
by
Environmental Monitoring Systems Laboratory
U.S. Environmental Protection Agency
Las Vegas, NV 93478
and
Health Effects Research Laboratory
U.S. Environmental Protection Agency
Research Triangle Park, NC 27711
May, 1991
ENVIRONMENTAL MONITORING SYSTEMS LABORATORY
OFFICE OF RESEARCH AND DEVELOPMENT
U.S. ENVIRONMENTAL PROTECTION AGENCY
LAS VEGAS, NEVADA 93478
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NOTICE
The information in this document has been funded wholly or
in part by the United States Environmental Protection Agency
under contract 68-CO-0049 to Lockheed Engineering and Sciences
Company, Environmental Monitoring Systems Laboratory, Las Vegas,
Nevada. It has been subjected to the Agency's peer and
administrative review, and it has been approved for publication
as an EPA document. Mention of trade names or commercial
products does not constitute endorsement or recommendation for
use.
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ABSTRACT
The U.S.EPA, through its Environmental Monitoring Systems
Laboratory-Las Vegas (EMSL-LV) and its Health Effects Research
Laboratory-Research Triangle Park (HERL-RTP) has been exploring
the feasibility of using biological markers to monitor exposure
to environmental chemicals. Among the candidate biomarkers of
exposure and effect are the adducts formed by reaction of
carcinogenic electrophiles with DNA and/or protein.
In 1987, the staffs of HERL-RTP, EMSL-LV, and Oak Ridge
National Laboratory (ORNL) conducted a study designed to identify
those chemical exposures of interest to the Agency which may be
effectively monitored using adduct-based techniques. The
participants began by compiling a list of chemicals of interest
to the EPA, i.e., chemicals which represent known or suspected
health hazard and for which the potential for human exposure
exists. The chemicals on this master list were then
systematically evaluated for (1) the potential for adduct-
formation in vivo. (2) the availability of supportive adduct
research data, (3) the identifiability of exposed population(s),
and (4) the level of genetic toxicological activity. After
considering all the relevant data, the participants selected and
prioritized for further study a small group of chemicals
considered to have the greatest potential for use in pilot,
adduct-based, biological monitoring studies in human populations.
iii
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CONTENTS
Abstract iii
Tables vi
Acknowledgments vii
1. Introduction 1
1.1 Objective 1
1.2 Background 1
2. Chemical Selection - The Initial Process 3
2.1 History 3
2.2 Methodology for Chemical Selection 3
2.2.1 Prioritization of Chemicals of interest
to the U.S.EPA 4
2.2.2 Adequacy and Quality of Adduct
Research Data 6
2.2.3 Potentially-exposed Human Populations 7
2.2.4 Genetic Toxicological Activity 9
2.3 Prioritization of Chemicals Selected for
Further Study 10
2.3.1 Styrene 10
2.3.2 Ethylene Oxide 10
2.3.3 4,4'-methylenebis(2-chloroaniline) (MOCA) ... 11
2.3.4 Benzidine 11
2.3.5 Vinyl Chloride 14
2.3.6 Epichlorohydrin 14
2.3.7 Propylene Oxide 14
2.3.8 Formaldehyde 14
2.3.9 Acrylonitrile 15
2.3.10 Pentachlorophenol 15
2.3.11 2,4-Toluene Diisocyanate 15
2.3.12 Chloroform 16
2.3.13 Chlordane 16
2.3.14 1-Nitropyrene 16
2.3.15 1,3-Dichloropropene 16
2.3.16 o-Toluidine 16
2.3.17 1,2-Dichloroethane (Ethylene Dichloride). ... 17
2.3.18 Benzyl Chloride 17
2.3.19 Dimethyl Carbamoyl Chloride 17
2.3.20 Mixtures 17
2.4 Conclusions and Recommendations 20
3. Chemical Selection - Subsequent Reports 21
3.1 Further Study on Selected Chemicals - DNA Adducts . . 21
3.2 Further Study on Selected Chemicals -
Protein Adducts 21
3.3 Chemical Adduct Profiles (Computerized) 23
IV
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CONTENTS (continued)
References 24
Appendices
A. Prioritized Sources of Chemical Lists A-l
B. Prioritized List of Chemicals of Interest to
the EPA B-l
C. Compounds Known to Form Adducts C-l
D. Prioritized Chemicals of Interest to the EPA
Known or Suspected to Form Adducts D-l
E. Adduct-Forming Chemicals not on EPA Lists E-l
F. Carcinogenic Chemicals not Known to Form Adducts . . . F-l
G. Adduct-Forming Carcinogenic Chemicals
not on EPA List G-l
H. Non-Adduct-Forming Chemicals Scored for Availability
of an Exposed Population Suitable for Study H-l
I. Chemicals Characterized for Their Potential
Human Exposure 1-1
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TABLES
Number page
1 Selected Chemicals for Further Study 12
2 Chemicals that Occur in Mixtures 18
3 Prioritized Protein Adduct-forming Chemicals 22
vi
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ACKNOWLEDGMENTS
This report would not have been possible without the efforts
of many individuals within the U.S. Environmental Protection
Agency, Health Effects Research Laboratory, Research Triangle
Park, NC (HERL-RTP); the Environmental Monitoring Systems
Laboratory, Las Vegas, NV (EMSL-LV); Oak Ridge National
Laboratory, Oak Ridge, TN (ORNL); and Lockheed Engineering and
Sciences Company, Las Vegas, NV (LESC). Technical assistance and
editorial comments were provided by the following people: Tamar
Gen, Gareth Pearson, Charles Nauman, Shelly Evans, and Llewellyn
Williams (EMSL-LV); Jack Griffith, Steve Nesnow, and Mike Waters
(HERL-RTP); Mayo Uziel, Tuan VoDinh, and Elaine Zeighami (ORNL);
and Stephen Soileau and Frank Schnell (LESC).
VII
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1. INTRODUCTION
1.1 OBJECTIVE
Genotoxic chemicals tend to form adducts with macromolecules
such as protein and DNA. These adducts could prove useful as
biomarkers of exposure. It was the objective of this project to
(a) identify and rank adduct-forming chemicals of interest to the
U.S. Environmental Protection Agency (EPA), and (b) to select the
most promising of those chemicals for further evaluation as
candidates for use in future molecular epidemiological and
exposure studies.
1.2 BACKGROUND
Historically, risk assessment has been based on exposure as
derived by estimation from environmental monitoring data,
simulation models, animal studies, and assumptions about actual
exposure conditions. More direct and non-invasive methods are
needed that will readily detect effects and/or changes in one or
more physiological parameters of the human body resulting from
environmental exposures.
A definite need exists for more sensitive and reliable human
exposure monitoring tools to better evaluate the health risk to
humans posed by chemicals in the environment. Improved risk
assessment is necessary to help set appropriate priorities for
the regulation and control of those chemicals that are of
concern. In response to the need to develop such monitoring
tools, the U.S. EPA has established a biomarkers/pharmacokinetics
research program . This research program, which has received
wide acceptance and support, was incorporated into the ORD FY
1988 base program. One of the goals of this program is to
develop biological markers that can serve as reliable indicators
of human exposure and of early (i.e., subclinical) disease
processes.
In the present context, biological markers are subcellular,
cellular, and organ-level physiological or biochemical responses
that can serve as indicators of chemical exposure and/or
exposure-related effects. Biological markers can be used to
measure innocuous biological responses to exposure as well as
adverse biologic and functional effects that may directly
correlate with health effects. Examples of biological markers
that may reflect exposure, and in some cases are thought to be
related to effect, include DNA and protein adduct formation,
micronuclei formation, enzymatic changes, immunological changes,
sister chromatid exchange, chromosome aberrations, and other
biochemical changes that occur in response to xenobiotics.
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The accuracy of risk assessments would be greatly enhanced
if external exposure data (i.e., measurements of the amount of
xenobiotic in contact with the individual) could be supplemented
with internal exposure data (i.e., biomarker measurements taken
directly from exposed human populations). The overall goals in
this area of study are to monitor exposure more accurately
through the use of biological markers and to evaluate the
molecular basis of the effects upon physiological processes and
the relationship of those effects to risk assessment and ultimate
risk management.
The U.S. EPA, through its Environmental Monitoring Systems
Laboratory-Las Vegas (EMSL-LV) and its Health Effects Research
Laboratory-Research Triangle Park (HERL-RTP) has been exploring
the feasibility of using biological markers to monitor exposure
to environmental chemicals. Among the candidate biomarkers of
exposure and effect are the adducts formed by reaction of
carcinogenic electrophiles with DNA and/or protein.
Certain carcinogens form electrophilic species that bind
covalently to macromolecules such as DNA, RNA, and protein. New
analytical methodologies including monoclonal antibody
techniques, 32P postlabeling, and gas chromatography-mass
spectrometry (GC/MS) have been developed to identify these
macromolecular adducts. Application of these techniques may
permit detection and quantitation of human exposure.
However, before such techniques can be applied in the field
with reasonable hope of success, it is first necessary to
identify those chemical exposures of interest to the Agency which
may be effectively monitored using adduct-based techniques. This
selection process is the subject of the next chapter.
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2. CHEMICAL SELECTION - THE INITIAL PROCESS
2.1 HISTORY
A meeting was convened on April 30-May 1, 1987, at HERL-RTP
to review information related to the selection of adduct-forming
chemicals and exposed human populations and to discuss the
utility of macromolecular adducts as molecular biomarkers.
(Since DNA adducts were the focus of the discussions at HERL, the
word "adducts" in this report will, unless otherwise indicated,
refer to "DNA adducts".) Present at the meeting were the staffs
of HERL-RTP, EMSL-LV, and Oak Ridge National Laboratory (ORNL).
Please see Acknowledgements.
At this meeting, the information on human exposures and
adduct-forming chemicals was evaluated in order to identify,
select and prioritize those adduct-forming chemicals of interest
to the Agency that show promise for use in future molecular
epidemiological or other studies. A review of the literature on
chemicals known to form adducts, their present level of adduct
research, and their corresponding analytical detection
methodologies was examined. This information was evaluated in
conjunction with each chemical's relative interest to the Agency
in terms of its known or suspected health hazard, its potential
for human exposure, as well as the availability of identified
populations having substantial and well-characterized exposure.
This evaluation resulted in the selection of a small group of
chemicals for further study based on their potential as
candidates for biological monitoring in human populations.
Candidate chemicals were selected for their high expectation
of demonstrating a useful exposure-dose relationship using adduct
detection methods in a human monitoring study. The following
discussion focuses on the methodology used to derive the selected
list of candidate chemicals considered to have the greatest
potential for a pilot human monitoring study.
2.2 METHODOLOGY FOR CHEMICAL SELECTION
The process of chemical selection was divided into four
steps based on the following four selection criteria: (1)
interest to the Agency, (2) availability of supportive adduct
research data, (3) availability of identified exposed
population(s), and (4) genetic activity (i.e., genotoxicity).
These criteria are discussed below in Sections 2.2.1 - 2.2.4.
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2.2.1 Prioritization of Chemicals of Interest to EPA -
The first step was to compile a list of prioritized
chemicals that are of interest to the Agency in terms of their
known or suspected toxicity. From this list were selected
chemicals that are known (or may be reasonably expected) to form
adducts with biological macromolecules. Subsequent ranking of
the latter chemicals led to the development of a candidate list
of high priority chemicals that are known to form adducts.
The following procedure was used to generate the list of
prioritized chemicals of interest to the Agency. A list of
chemicals considered to be of high priority in terms of their
potential health hazard was requested from each of the U.S. EPA
Program Offices. The sources of these lists can be found in
Appendix A. The lists were reviewed in an effort to eliminate
those selections not based on potential toxicity hazard. The
lists of chemicals from each Program Office were then
prioritized, based on the number of times each chemical appeared
on the Program Office lists. All the prioritized lists were then
combined into a common prioritized list.
The prioritization scheme (Zeighami et al., 1987) used a
main prioritization as well as a subprioritization. The main
prioritization (PI) was determined by the number of Program
Offices which listed that chemical on one or more lists. The
subprioritization (P2) was derived by subtracting the main prior-
itization number from the total number of lists on which the
chemical appeared. Formaldehyde, for example, received a rating
of 5.(PI) 3.(P2) because it appeared on 8 lists from 5 different
Program Offices. This scoring system provided a means of ranking
chemicals that were listed by the same number of Program Offices
(i.e., had identical P, ratings), and reduced the likelihood of
bias toward any particular Program Office as a result of multiple
listings of chemicals by that office. For example, although 4-
aminobiphenyl (4-ABP) and sulfuric acid both appeared on 3
separate lists, 4-ABP received the higher ranking because it was
listed by 3 different Program Offices, as compared to only one
for sulfuric acid. The final prioritized list (Appendix B)
consisted of approximately 1,585 chemicals.
The prioritized list of chemicals of interest to the Agency
was then cross referenced with a list of 13.1 chemicals (Appendix
C) that were known to form adducts. The list of chemicals known
to form adducts was based on a review of the literature found in
the 1987 U.S.EPA report, "Carcinogen-DNA Adducts: Introduction,
Summary, and Recommendations" (EPA/600/4-87/005), and updated
with newly received information from ORNL, literature sources,
conference attendances, and other personal communications.
Sixty three of the chemicals listed in Appendix B had at
least some data indicating that they form adducts. The potential
candidates for further research and evaluation were, with a few
exceptions, selected from this list of 63 compounds (Appendix D).
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Supplemental sources:
It was considered that six chemicals not listed in Appendix
D might warrant further study in the future. These chemicals
(Pentachlorophenol, 2,4-toluene diisocyanate, chlordane, 1-
nitropyrene, 1,3-dichloropropene, and malathion) were brought
into the selection procedure at the level of Appendix D
chemicals. Most were found on lists of chemicals (see below)
which were not known to form DNA adducts and/or were not on the
list of chemicals "of interest to the Agency".
Sixty-eight of the chemicals known to form adducts were not
on the Agency list; they are found in Appendix E. Although none
of these chemicals was initially selected for further study, it
was considered that some of them (e.g., nitropyrene) might
warrant reconsideration at a later date.
Appendix F lists 167 chemicals which, though not known to
form DNA adducts, are classified as known or suspected human
carcinogens in the "Fourth Annual Report on Carcinogens" (PB-85-
134663) , published by the Department of Health and Human Services
and the International Agency for Research on Cancer (IARC) and
the U.S. Public Health Services National Toxicology Program
(NTP). It is probable that many of these chemicals (e.g., solid
state carcinogens, hormones, and immunosuppressants) exert their
carcinogenic properties via some epigenetic mechanism, i.e., one
which does not involve direct interaction with DNA. It is also
possible that some of these chemicals do form adducts but that
either (1) they had not yet been tested for adduct-formation, or
(2) the adducts they form were not yet detectable with the
methods then applied. Also, other chemicals such as 2,4-toluene
diisocyanate may form protein adducts of potential use in
exposure monitoring.
A review of the genetic toxicological activity profiles
(see Section 2.2.4.) of these chemicals (and others not initially
included in Appendix D) could be useful for identifying high
priority chemicals that warrant preliminary research into their
adduct-forming potential. For example, such considerations,
combined with the potential for human exposure and adverse health
effects, lead to the subsequent inclusion of chlordane and 1,3-
dichloropropene, even though neither of these chemicals appears
on any of the primary lists used in the study (i.e., Appendices
B, C, and D).
Appendix G lists adduct-forming, suspect carcinogens that do
not appear on the prioritized list (Appendix B). Most of these
chemicals are drugs or research chemicals which are not subject
to regulation by the EPA. Although none of these chemicals were
ultimately selected for further study, they are nevertheless of
interest from a research perspective due to the high quality of
the related exposure data.
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Appendix H (a subset of Appendix I) lists chemicals not
known to form DNA adducts but which were scored for the
availability of an exposed population for study. Four chemicals
from Appendix H - 2,4-TDI, PGP, 1,3-dichloropropene, and
malathion - were ultimately selected for further study. The
neurotoxicant acrylamide, while not selected for further study at
this time, was later included in a study of the potential of
protein adduct-forming chemicals for exposure monitoring (see
Section 3.2).
2.2.2 Adequacy and Quality of Adduct Research Data -
The second step in the chemical selection process was to
assess the quality and adequacy of the research data on the
adduct-forming chemicals of interest to the Agency (Appendix D).
A large amount of preliminary research and a variety of data are
included under the research status category. Information on
covalent binding, chemical adduct identification, in vitro
studies, validation in animal studies, DNA adduct measurement,
protein adduct measurement, biological media and species
monitored, dose-response data, kinetics of adduct formation and
removal, the chemical stability of adducts formed, the chronic or
acute nature of the exposure (continuous exposure, single-dose,
multiple-dose, etc.), and the corresponding analytical detection
methodology all become important in assessing the research data.
The quality and adequacy of available adduct-formation data
on the chemicals (research status) is an important criterion in
selecting candidates for a pilot study in the imminent future. A
substantial research data base, particularly validated animal
studies, is necessary before a chemical can be monitored in an
epidemiological or other study. Evaluation of the research
status also identifies data needs for which research should be
designed and initiated. Updating the research status must be a
continuing- effort.
Initially, the lists of chemicals in Appendix D were
screened for chemicals that could be eliminated a priori for one
or more of the following reasons: (1) adduct formation by the
chemical, though possible, was considered unlikely for structural
reasons, (2) the literature contained insufficient adduct
information to support the chemical's candidacy, or (3) the
adduct formed by the chemical was a small alkylation product
(e.g., 7-methyl guanine or 7-ethyl guanine) that lacked
sufficient specificity for exposure monitoring (i.e., the same
adduct could have endogenous sources and/or be formed by two or
more confounding exposures). The Appendix D chemicals so
eliminated are marked with a negative sign (-) next to their
sequence number. It should be kept in mind, however, that these
alkylating agents may still be useful in screening studies to
identify exposure to certain classes of chemicals (rather than to
individual chemicals). In addition, some of these chemicals
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might display a specific adduct-binding pattern that would
increase their specificity and sensitivity, thus making them
useful for monitoring exposure (Osterman-Golkar, 1983; Svensson
and Osterman-Golkar, 1986; Osterman-Golkar and Bergmark, 1988).
Chemicals in Appendix D were marked with a plus sign (+) if
(1) they were fairly well represented in the literature on adduct
research, or (2) sufficient preliminary data (i.e., ongoing
research) existed to support their candidate potential. In
general, it was decided that the chemical(s) selected for the
initial study should be one(s) that form chemical-specific
adducts that can be identified with relative ease. Chemicals
that form bulky, chemical-specific adducts were generally
preferred over those that form small, non-specific, adducts.
Serious consideration was given to choosing those chemicals for
which a large part of the information needed was already
available. However, chemicals eventually selected for further
study (Tables 1 and 2) must also satisfy the requirement for an
identifiable, exposed population in which human exposure might be
monitored.
2.2.3 Potentially Exposed Human Populations -
The third step in the chemical selection process was the
identification and characterization of potentially exposed human
populations to those chemicals according to the criteria outlined
below. The chemical list used in this part of the study was a
subset of a combined list of chemicals from two databases: (1)
the GENE-TOX database (Waters and Auletta, 1981), and (2) the
Genetic Activity Profile (GAP) database (Waters et al., 1988).
Project officers at the U.S. EPA determined which chemicals from
the combined list would be used in the population study. The
selected chemicals tended to be those that were either known or
considered likely to form adducts, based on chemical structure
and available genotoxicity data. Appendix I lists the 253
chemicals that were subsequently examined and characterized by
Zeighami et al. (1987) for the availability of exposed
populations for study.
The following criteria were used in scoring the chemicals on
their human population exposure potential:
(1) population availability - An essential element of any
epidemiological study is the availability of an exposed
population that is accessible, in a practical manner,
to the researchers performing that study.
(2) population size (best estimate) - The size of the
population(s) chosen for epidemiological study will
affect the practical performance of that study as well
as the statistical significance of its results.
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(3) level of exposure - In a population suitable for
molecular epidemiological study, the expected level and
duration of exposure must be such that the resultant
adduct levels will be within analytical detection
limits.
(4) quality of exposure history - The validity of exposure
estimates will depend upon the ability to reconstruct
past exposures, as well as the ability to validate
present exposures using measurements other than the
test biomarker.
(5) degree of confounding multiple exposures - The
interpretability of the study results will be affected
by the degree to which persons in the study population
are (a) exposed to the same chemical in multiple
situations, or (b) concurrently exposed to other
chemicals in the primary exposure situation.
Each criterion was assigned a score from 0 to 3. The
resulting overall score for a chemical was the product of the
individual criterion scores which could yield a maximum score of
35 or 243. Scores were assigned only to those chemicals for
which adequate information on exposed populations was found. The
categories of anti-neoplastic drugs and other medications were
not scored. Summaries were assigned to a total of 58 chemicals
for which adequate information was located (Appendix I, pg 1-1).
Of these, only 33 had a score greater than zero, and only 23 had
a score of 36 or higher (of a possible 243). The remaining 195
chemicals (Appendix I, pages 1-2 through 1-5) received no score
due to the absence of sufficient data.
It should be pointed out that the multiplicative scoring
scheme used here would have eliminated (i.e., given a score of
"0" to) any chemical that received a zero score on any of the 5
criteria, regardless of how high the scores might have been in
the remaining criteria. Six chemicals thusly "eliminated" were
among those ultimately chosen for further study (Table 1) because
their potential in other areas warranted their selection.
The selected adduct-forming chemicals of interest to the
Agency (Appendix D) were then re-examined in light of the
relevant human population exposure data (Appendix I). Chemicals
for which the exposed population was small or nonexistent were
marked with an "o" next to their sequence number in Appendix D;
those chemicals considered to be ubiquitous in nature were marked
with a "U" next to their sequence number. The widespread
occurrence of a chemical would complicate efforts to establish a
relationship between a source of exposure and adverse health
effects.
Chemicals that typically occur as components of mixtures,
and for which exposure to the pure compound is rare, were marked
with an "M" next to their sequence number. These were reviewed
8
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separately due to the difficulties that arise in ascribing
effects on human health to a particular chemical in a mixture.
However, chemicals that typically occur in mixtures can still be
useful for exposure monitoring studies in which direct
correlations with health effects are not always necessary.
Those chemicals in Appendix D considered likely to have
well-defined exposed populations are identified by an asterisk
(*) next to their sequence numbers. Those chemicals marked with
both an asterisk (*) and a plus sign (+) are those for which
well-defined exposed populations as well as supportive adduct
research data were considered to exist.
After the elimination of those chemicals that did not meet
the general criteria described above, the remaining chemicals
were listed (Table 1) as potential candidates for adduct-based
human monitoring studies. These chemicals then became the
subject of detailed discussions, on a compound-by-compound basis,
centering on the adducts formed, current research status,
population availability and genetic toxicological activity.
2.2.4 Genetic Toxicological Activity -
Genetic toxicity was one of the primary criteria considered
in ranking the chemicals selected for further study in Table 1.
The genetic toxicological activity of a compound, as measured by
various bioassays, is relevant to both (1) the potential hazard
it poses to human health and, hence, its interest to the EPA, and
(2) the likelihood that the chemical will form detectable
macromolecular adducts and, thus, be potentially useful in the
present study. Genetic activity profiles (Garrett et al., 1984;
Waters et al., 1988) were particularly useful in rating those
chemicals for which little adduct information was available.
Genetic activity profiles represent the available
qualitative and quantitative genotoxicity data from short-term
tests in a standardized graphical format. The data for a given
chemical is presented in a bar or line graph (the activity
"profile") in which test systems (identified by three-letter
codes) are displayed along the x-axis in either a phylogenetic or
endpoint sequence and values corresponding to the doses employed
in the tests are shown on the y-axis (Waters et al., 1988). The
logarithmically-transformed values on the y-axis represent either
the lowest effective doses or the highest ineffective doses
tested. The total data available from short-term tests for a
compound are thus presented in a condensed format that allows
rapid visualization of the type of genetic (or related) effects
induced, and facilitates comparisons among different chemicals.
Genetic activity profiles have been prepared and compared
for 24 known or suspected human carcinogens (Garrett et al.,
1984), six well-known organic solvents (Vainio et al., 1985),
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65 pesticides (Garrett et al., 1986), and six priority compounds
found at Superfund Ammendments and Reauthorization Act (SARA)
sites (Waters et al., 1987).
The International Agency for Research on Cancer (IARC) has
employed the genetic activity profile methodology in several of
its Monographs on the Evaluation of Carcinogenic Risks to Humans
(IARC, 1985a, 1985b, and 1986). Supplement 6 to the IARC
Monographs (IARC, 1987) summarizes and updates the findings from
genotoxicity tests in experimental systems and humans for 195
compounds that had been previously evaluated in Volumes 1-42 of
the Monographs and for which some data on carcinogenicity to
humans were available. (Note: The GAP database has since expanded
to include data on more than 400 chemicals. It is available on
disk through Dr. Michael D. Waters of the U.S. EPA, Health
Effects Research Laboratory, Research Triangle Park, N.C. 227711.
2.3 PRIORITIZATION OF CHEMICALS SELECTED FOR FURTHER STUDY -
Table 1 lists by assigned priority those chemicals that were
not eliminated during the 4 steps of the chemical selection
process described previously. The chemicals were assigned a
high, medium, or low priority based on adduct data, current
research status, population availability, and genetic activity.
An unclassified category for reconsideration was established for
those chemicals for which the potential for study existed, but
for which the information available at the time was insufficient
to support any judgment.
Special consideration was given to those few chemicals for
which a fair amount of preliminary research existed to support
their selection as potential candidates. When all criteria were
considered, the 7 chemicals that received the highest (i.e., high
or medium) ratings were styrene, ethylene oxide, 4-4'methylene
bis(2-chloroaniline) (MOCA), vinyl chloride, epichlorohydrin,
propylene oxide, and benzidine. A discussion of the assigned
priority of individual chemicals in Table 1 follows.
2.3.1 Styrene -
Styrene ranked high for genetic toxicity evidence,
supportive adduct information, and population availability.
Also, a large ongoing research effort on Styrene-DNA adducts at
the Institute of Occupational Health in Finland existed at the
time (Hemminki, 1986), and has continued to generate useful
research data since (Vodicka and Hemminki, 1988; Heminki et al.,
1988, 1990).
2.3.2 Ethylene Oxide -
Ethylene oxide also ranked high for genotoxicity
information, potentially exposed populations, and amount of
research effort. It has caused cancer in rats and mice (NTP,
1985) and is a suspected human leukemogen (IARC, 1985a). Ethylene
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oxide occurs in urban air and in cigarette smoke and is used in
the manufacture of antifreeze and in the sterilization of medical
equipment. Hospital sterilization workers and patients using
ethylene oxide-sterilized renal dialysis equipment provide an
exposed population for study. There is sufficient evidence of
carcinogenicity of ethylene oxide in experimental animals, but
not in humans (NTP, 1985, IARC, 1985a).
Both ethylene and ethylene oxide cause 2-hydroxyethylations
of protein and DNA, and the ratio between protein and DNA
alkylation products in various organs is relatively constant
(Segerback, 1983). At the time of the Spring 1987 meeting at
HERL-RTP, a substantial amount of research, including human
monitoring studies (Calleman et al.,1978; Van Sittert et al.,
1985; Farmer et al., 1986; Calleman, 1986; Tornqvist et al.,
1986; Wraith et al., 1987; Passingham et al., 1987; Tornqvist et
al., 1989), had already been done on ethylene oxide-hemoglobin
adducts. Also, both the Columbia University School of Public
Health and the National Institute for Occupational Safety and
Health (NIOSH) had proposed doing human monitoring studies with
ethylene oxide.
Nevertheless, there was some disagreement on the selection
of this chemical, primarily because of potential problems posed
by multiple sources of exposure and background levels of ethylene
oxide adducts. Ethylene (or ethene), the metabolic precursor of
ethylene oxide, is a well-known environmental contaminant and it
is known to be produced endogenously as well.
2.3.3 4.4'-methvlene bis(2-chloroaniline) (MOCA1 -
MOCA was ranked medium/high based on the availability of
supportive research data and the identification of a well-defined
population. Although no data were available on the genotqxicity
of MOCA in humans, this arylamine was known to be carcinogenic in
mice, rats and dogs (Manis et al., 1984), and was suspected to
cause bladder cancer in man. Its mutagenicity has since been
demonstrated in the Ames assay (Kuslikis et al., 1988). MOCA is
no longer manufactured in the U.S., but it is widely used by
numerous small companies in the polyurethane industry.
2.3.4 Benzidine -
Benzidine was ranked medium/high based on genotoxicity data,
population availability, and the large amount of supportive
adduct research data. The building block of an entire family of
widely-used dyes, benzidine is a urinary bladder carcinogen in
humans and dogs and a hepatocarcinogen in rodents (Talaska et
al., 1987). A fair amount of research has been done on
biomarkers of benzidine exposure (Martin and Ekers, 1980; Martin
et al., 1982, 1983; Kennelly et al., 1984; Martin and Kennelly,
1985; Beland et al., 1983; Beland and Kadlubar, 1985; Mitchum et
al., 1985), including a recent biomonitoring study based on
hemoglobin-adduct measurements (Birner et al., 1990).
11
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TABLE 1. PRIORITIZED CHEMICALS SELECTED FOR FURTHER STUDY
Number3
Chemical
Rating0
Data Summary
Styrene
H Genetic activity = high. Good population data. Supportive adduct
research studies.
2.(4)
3.(29)
4.(18)
Ethylene oxide
H
4,4-Methylene
bis (2-chloro-
aniline) (MOCA)
Benzidine
M/H
H/H
Genetic activity - high. Available populations: hospital sterili-
zation workers and patients receiving treatment through the
sterilized equipment used for cases such as renal dialysis, which
provides more consistent dosing than bypass surgery. Numerous
human studies using Kb adducts have been conducted.
Genetic activity = low. Available population. Active research
support.
Genetic activity = high.
research data.
Available population. Supportive adduct
5.(2)
Vinyl chloride
6.(19)
7.C25)
8.(3)
10.(N/A)
Epichlorohydrin
Propylene oxide
Formaldehyde
Acrylonitrile
Pentachloro-
phenol
M/H Genetic activity - high. Population available, but numerous
confounding exposures include vinyl bromide, acrylonitrile, 1,2-
dichloroethane, 1,2 dibromoethane, ethylene halohydrins, and
urethane. Also, exposure might be low and it must be determined
if adducts would be formed at these levels. Additional research
data is necessary for support.
M/H Genetic activity » medium. Reasonable population in production
workers. Needs further validation from animal studies.
M/H Genetic activity = similar to ethylene oxide profile, although not
as much information has been collected. Ubiquity could be a
problem. Needs more supportive research data.
L/M Genetic activity s high. Ubiquitous. Changed from H to L/M
because it was believed that the separation of endogenous/-
exogenous adduct formation would be difficult and some reactivity
may be reversible. (CUT)
L/M Genetic activity = positive in vitro, questionable in humans.
Available population.
Genetic activity = minimal.
population is questionable.
Additional data needed.
Availability of unconfounded exposed
Indirect adduct formation.
11.(N/A) 2,4-toluene U/Ex Genetic activity » inadequate information. Population available.
diisocyanate Need more information, particularly on protein adducts as exposure
biomarkers.
12
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TABLE 1. (continued)
Number3
12. (6)
13.(N/A)
U.CN/A)
15.CN/A)
16. (55)
17.(5)
18. (41)
19. (40)
20.(N/A)
21. (33)
22. (57)
23. (38)
Chemical
Chloroform
Chlordane
Nitropyrene
1,3-dichloro-
propene
Toluidine, 0-
Ethylene
dichloride
Benzyl chloride
Dimethyl
carbamoyl
chloride
Ha lath ion
Hephalan
Mitomycin C
Thioacetamide
Rating13 Data Summary
U/Ex Genetic activity = low. Exposed populations require further
study. Investigate potential of protein adducts.
U/Ex Review all criteria.
U Review all criteria.
U Review all criteria.
U/L Genetic activity * low. Population questionable. Minimal adduct
information. Investigate protein adduct formation.
U More information is needed on all criteria. Could demonstrate a
unique adduct.
L/M Genetic activity needs to be determined. Additional information
U/Ex is needed.
U/L Genetic activity needs to be determined. Population data were
were questionable. Minimal supportive research data.
U/L Investigate protein adduct formation.
Put aside for possible use in other studies.
a n
H II
The chemicals in Table 1 were rated on their genetic activity, adduct formation, exposed population
availability, and research status. Definitions of the notation used are as follows:
8 (#) The number in parentheses is the sequential number as it appeared in Appendix D.
(N/A) Indicates that the chemical is not listed in Appendix D.
b L Indicates a low priority ranking.
M Indicates a medium priority ranking.
H Indicates a high priority ranking.
U Indicates an unclassified rating. Assigned to chemicals for which the potential for study existed,
but for which the information available at the time was inadequate to support any judgement.
Ex Indicates that further information is desired on exposure monitoring of protein adducts.
13
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2.3.5 Vinvl Chloride -
Vinyl Chloride was ranked medium/high based on its high
genotoxic activity and the potential to find a well-defined,
exposed population. However, additional research data is
required to support the candidacy of this chemical. Current
exposure to vinyl chloride, a known human carcinogen, is likely
to be quite low. Thus, it will be necessary to establish a dose-
response relationship at low levels of exposure, provided that
detectable levels of adducts are even formed at low exposure
levels. In addition, a vinyl chloride-exposed population must be
selected in such a way as to minimize confounding exposures such
as vinyl bromide, 1,2-dihaloethanes, ethylene halohydrins,
urethane, and acrylonitrile. The toxicology of vinyl chloride
has recently been reviewed (ATSDR,1989b).
2.3.6 Epichlorohydrin -
Epichlorohydrin was ranked medium/high based on
genotoxicity data and population availability. Although this
compound is mutagenic in bacteria and carcinogenic in animals,
adequate evidence of carcinogenicity in humans does not yet
exist. More adduct research data is needed to support the
candidacy of epichlorhydrin.
2.3.7 Propylene Oxide -
Propylene oxide received a medium/high rating and
displayed genetic activity data very similar to the ethylene
oxide profile. Due to its mutagenicity in bacteria and its known
carcinogenicity in experimental animals, propylene oxide is
regarded as a probable carcinogenic risk to humans (IARC, 1985a).
It was rated high for the availability of populations with
relatively high exposure levels and medium for supportive adduct
research information. The background levels of adducts of-
propylene oxide are lower than those of ethylene oxide, but much
less research has been done on propylene oxide.
2.3.8 Formaldehyde -
Formaldehyde is a chemical of high interest to the Agency
due to the recent evidence of animal carcinogenicity, i.e. the
induction of nasal neoplasms in rats reported by Swenberg et al.,
1985. The potential for human exposure is great since
formaldehyde occurs in urea-formaldehyde foam insulation, in
resins used to manufacture pressed-wood construction materials
and durable-press fabrics for clothing, and in cigarette smoke.
However, formaldehyde also occurs naturally in all
biological tissues, and it may be difficult to separate the
induced N-7 methyl guanine adduct from the endogenous DNA adduct.
In addition, some DNA adduct-formation may be reversible
14
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(Swenberg et al., 1985). Consequently, formaldehyde was given a
low/medium ranking. More research is needed to support the
candidacy of this chemical.
2.3.9 Acrvlonitrile -
Acrylonitrile also received a low/medium ranking and
appeared to lack the necessary supportive research data to
warrant further study. Genotoxicity data were equivocal or
negative and insufficient data were available on adduct formation
in vivo. However, population availability and exposure
characteristics were rated adequate to high. The primary hazard
of acrylonitrile is acute toxicity following the metabolic
release of cyanide, but this chemical has also caused cancer in
experimental animals and is a possible human carcinogen (NTP,
1985). Protein adducts may have more potential than DNA adducts
as biomarkers of exposure to acrylonitrile. The epoxide
metabolite, but not the parent compound, forms adducts with DNA,
whereas both can bind to proteins (Hogy and Guengerich, 1986) .
The remaining candidates for further consideration due to
their potential for human population exposure were
pentachlorophenol, 2,4-toluene diisocyante, chloroform, 1,3-
dichloropropene. Most of these chemicals were categorized as
unclassified because they required additional information before
any valid judgement could me made. Chlordane and nitropyrene
were also included as important chemicals requiring further
information in all selection criteria areas. Additional
unclassified chemicals which remained on the adduct-forming list
of chemicals of interest to the Agency (Appendix D) that might
have potential for further study but lacked adequate information
were o-toluidine, ethylene dichloride, benzyl chloride and
dimethyl carbamoyl chloride. These chemicals were included in
Table 1, and prioritized as follows:
2.3.10 Pentachlorophenol -
Pentachlorophenol received a low rating due to minimal
genetic toxicity data and weak adduct-formation by metabolites.
Wood-treatment workers provide an adequate human population for
human study, but high concomitant exposures to other chemicals
were projected. The toxicology of pentachlorophenol has recently
been reviewed (ATSDR,1989c). More research in all areas is
needed to support pentachlorophenol as a potential candidate.
2.3.11 2.4-toluene diisocyanate -
2,4-toluene diisocyante (TDI) was placed in the
unclassified category to be reconsidered after additional
information became available. A potent respiratory allergen, TDI
is widely used in the manufacture of polyurethanes. This
chemical ranked adequate to good from the human population
standpoint, but adequate genetic toxicology data were lacking.
15
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Although TDI is carcinogenic in rats and female (but not male)
mice (NTP, 1985), the literature contains no reference to TDI-DNA
adducts or other genetic damage in animals.
2.3.12 Chloroform -
Chloroform had a high population score, but DNA adduct
information was inadequate. Although chloroform has caused
cancer in rodents (NTP, 1985), it is not mutagenic, and there is
no evidence as yet that it is a human carcinogen. Protein
adducts may have some potential for monitoring exposure to
chloroform (Pereira and Chang, 1982), but here, too, information
was inadequate. Additional research data is needed to justify
reconsideration of this chemical. The toxicology of chloroform
has recently been reviewed (ATSDR, 1988a).
2.3.13 Chlordane -
This chlorinated hydrocarbon insecticide may be an
appropriate candidate, but information in all areas of evaluation
was inadequate. Although it has induced liver tumors in at least
one test species (IARC, 1983), chlordane is not genotoxic and is
classified as an epigenetic carcinogen of the promoter type.
2.3.14 1-Nitropyrene -
This chemical was placed in the unclassified category to
be reconsidered after more adduct information became available.
A widespread environmental contaminant found in diesel exhaust,
1-nitropyrene is mutagenic and has caused cancer in rats (IARC,
1989). However, in at least one study, efforts to detect DNA-
nitropyrene adducts in exposed rats were unsuccessful (Jackson et
al., 1985). Also, human exposure levels are probably quite low.
The development of an immunoassay for nitropyrene or its adducts
in exposed humans may be possible in the future (Groopman, 1987).
2.3.15 1.3-dichloropropene -
1,3-dichloropropene could not be classified at this time/-
more information on all evaluation criteria was required. This
chemical is used as a soil fumigant and human exposure is
expected to occur. Although 1,3-dichloropropene is mutagenic,
the absence of adduct data and the unpredictability of exposure
made this chemical less appropriate for study than others.
Additional chemicals that were reconsidered, although
they were initially felt to have poor population availability,
were ranked as follows:
2.3.16 o-Toluidine -
This arylamine was ranked low because of insufficient
data on genotoxicity, and adduct formation, and because human
population exposures may no longer be prevalent. Like a number
16
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of substituted anilines, o-toluidine is weakly carcinogenic in
rodents at high doses. However, the evidence of the
carcinogenicity of o-toluidine is inadequate in humans (NTP,1985)
More research is needed to support the candidacy of o-toluidine.
2.3.17 1.2-Dichloroethane (ethylene dichloride) -
This chemical received a low population score because of
an apparent lack of appropriate human populations for study.
Ethylene dichloride (1,2-dichloroethane) could have potential
based on its high genotoxicity and the unique episulfonium ion-
glutathione adduct that occurs with the dihaloethanes (Guengerich
et al., 1987). Studies in the mouse indicate that hemoglobin
adducts (i.e., 2-hydroxyethylations of cysteine, histidine and
valine) are also formed in vivo (Svensson and Osterman-Golkar,
1986). This chemical was placed in the unclassified category to
be reconsidered in the event that additional research data became
available. The toxicology of 1,2-dichlorethane has recently been
reviewed (ATSDR, 1989d).
2.3.18 Benzyl Chloride -
This chemical was placed in the low to medium rating
group because the available information was inadequate in all
areas under consideration. Nevertheless, benzyl chloride is both
mutagenic and carcinogenic, and apparently binds to both DNA and
hemoglobin (Walles, 1981). In addition, the potential for some
human exposure does exist. Future additions to its meager
research database may justify reconsideration of benzyl chloride.
2.3.19 Dimethyl carbamovl chloride -
Dimethyl carbamoyl chloride received a low ranking due to
questionable population data and minimal supportive research
data. More research data is needed to support the candidacy of
this chemical.
2.3.20 Mixtures -
Chemicals listed in Table 2 were classified as mixtures
since exposure to the pure compound rarely occurs. While there
was considerable interest in the potential for monitoring
exposure to some of these chemicals, it was also recognized that
(1) it would be difficult, due to the presence of confounding
exposures, to attribute health effects to any specific component
of a mixture (e.g., N-nitrosonornicotine in tobbaco smoke), and
(2) that potentially high background levels of adducts to
ubiquitous chemicals such as benzene, benzo(a)pyrene, and 4-
aminobiphenyl might preclude detection of all but the highest
exposures. Two compounds, 3-Methylcholanthrene and 7, 12-
dimethyl benzanthracene, were eliminated because they are rarely
used except in research situations. Benzidine and nitropyrene
were also listed in Table 1 and were described above.
17
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TABLE 2. CHEMICALS THAT OCCUR IN MIXTURES
Number*
Chemical
Rating6
Data Summary
1.(18> Benzidine H/Ex
2.(1) Benzene H/Ex
3.(17) Benzo(a)pyrene
4.(32) 4-Aminobiphenyl M/Ex
Population thought to be available in the dye industry.
Supportive research data on protein as well as DMA adducts.
Ubiquitous in the environment. Cohort population identified in
China. Ongoing research activity.
Need highly exposed population such as coke oven workers
due to the high background levels of adducts. Extensive research,
including human monitoring studies.
Ubiquitous in the environment. Several studies on 4-aminobiphenyl
hemoglobin adducts in smokers.
5. (50)
6.(N/A)
7. (23)
8.(24)
Nitrosonor-
nicotine, N-
1-Nitropyrene
3-Methylchol-
anthrene
Benzanthracene,
7,12-Dimethyl
M/Ex Population may be available in smokeless tobacco users.
NNN-DNA adduct can be easily identified. Fair amount of
preliminary research, including protein adducts.
M Identified population in China. Active research.
N Rarely used except in research setting.
N Rarely used except in research setting.
The chemicals in Table 2 were rated on their genetic activity, adduct formation, exposed population
availability, and research status. Definitions of the notation used are as follows:
' (#) The number in parentheses is the sequential number as it appeared in Appendix 0.
(N/A) Indicates that the chemical is not listed in Appendix D.
b L Indicates a low priority ranking.
M Indicates a medium priority ranking.
H Indicates a high priority ranking.
U Indicates an unclassified rating. Assigned to chemicals for which the potential for study existed,
but for which the information available at the time was inadequate to support any judgement.
Ex Indicates that further information is desired on exposure monitoring of protein adducts.
18
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Benzo(a)pyrene adducts have been extensively researched
in both animals and humans. However, in human monitoring studies
to date, benzo(a)pyrene adduct levels have exhibited extreme
individual variability and been statistically different from
controls only in groups with high exposure (Harris et al., 1985;
Phillips et al., 1988; Lee and Santella, 1988; Weston et al.,
1989). Protein (especially serum albumin) adducts may have more
potential than DNA adducts as biomarkers of exposure to
benz(a)pyrene. This is certainly the case with another
ubiquitous, carcinogenic, environmental contaminant, 4-
aminobiphenyl.
Recent human monitoring studies of cigarette smokers and
nonsmokers have demonstrated consistently higher levels of 4-
aminobiphenyl-hemoglobin adducts in smokers (Tannenbaum et al.,
1986; Bryant et al., 1987; Perera et al., 1987; Bryant et al.,
1988; Maclure et al., 1990). These adducts are also elevated in
passive smokers, i.e., non-smokers exposed to environmental
tobacco smoke (Maclure et al., 1989). Furthermore, levels of 4-
aminobiphenyl-hemoglobin adducts have been found to be
proportional to risk for bladder cancer (Vineis et al., 1990).
Simultaneous measurements of the serum albumin adduct, if they
could be made in humans, might even clarify the link between
cancer risk and interindividual variation in acetylation activity
(Skipper et al., 1985).
Benzene is of considerable interest to the U.S. EPA from
the standpoint of exposure monitoring. Although little adduct
data was available for benzene, it was ranked high for potential
exposure and health effects. A human leukemogen (NTP, 1985),
benzene occurs naturally in the environment and is produced in
vast quantities for use as a chemical intermediate in the
synthetics industry. More information on the potential of
hemoglobin- and DNA-benzene adducts for exposure monitoring
should become available as ongoing research programs progress at
Rutgers, Berkely, and the Lovelace Inhalation Toxicology Research
Institute. In light of its potential health hazard and its
growing research database, benzene may warrant reconsideration in
the near future. The toxicology of benzene has recently been
reviewed (ATSDR,1988b).
N-Nitrosonornicotine (NNN) forms a unique adduct and is
found in cigarette smoke and smokeless tobacco. This chemical
could be a good choice in terms of exposure monitoring since the
NNN-DNA adduct can easily be attributed to tobacco. It is not a
suitable candidate in terms of health effects due to the presence
of other carcinogens. Smokeless tobacco, however, does not
contain such pyrolysis-produced carcinogens as benzo(a)pyrene,
5-methylchrysene, and dibenz(a,h)anthracene. Ongoing protein
adduct research at the American Health Foundation (Carmella et
al., 1987; Carmella and Hecht, 1987; Hecht et al., 1988) may, at
some future date, justify reconsideration of this chemical.
19
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2.4 CONCLUSIONS AND RECOMMENDATIONS -
It was concluded by the Working Group in 1987 that the
information on the chemicals in Tables 1 and 2 should be
periodically updated by via reviews of the current literature and
other mechanisms such as conferences and personal communication.
Particular emphasis was to be put on the following 13 chemicals:
styrene, ethylene oxide, 4-4'methylene bis(2-chloroaniline)
(MOCA), benzidine, vinyl chloride, epichlorohydrin, propylene
oxide, benzyl chloride, formaldehyde, chlordane, nitropyrene,
1,3-dichloropropene, and ethylene dichloride. Any additional
information that might substantiate the selection of
acrylonitrile, pentachlorophenol or other chemicals that had been
eliminated or not considered would also be welcomed.
It was considered that certain low priority chemicals
(e.g., chloroform, 2,4,-toluene diisocyanate, benzyl chloride, o-
toluidine, and malathion) might be useful in exposure monitoring
studies based on measurement of protein adducts, but more
research data were needed. Benzene, benzo(a)pyrene, 4-amino-
biphenyl, and N-nitrosonornicotine also required a summary of
ongoing research and an assessment of exposed populations.
It was recommended that any adduct research on pesticides
such as aldrin, amitrole, avadex, aramite, captan, chloramben,
chlordimeform, chlorothalonil, diallate, diaminazide, dicofol,
chlorbenzilate, p,p'-DDT, dieldrin, mirex, strobane, heptachlor,
and toxaphene be reviewed.
Finally, it was suggested that the chemical-adduct
research data for each chemical could be entered into the
computer to form an updated informational system very similar to
the computer-generated genetic activity profiles. Aside from its
value as a compact informational chemical adduct library, it
would be extremely valuable to visually analyze complex data in
terms of adduct structure-activity relationships. An analysis of
such a database could further our understanding of the
relationship between chemical structures and properties,
chemically similar structures, adducts formed, and the associated
health effects. It could thus assist in identifying those
adducts of probable importance in the mechanisms of
carcinogenesis.
The efforts of the 1987 workgroup represented the first
step in the development of the Biomarkers Program of the U.S.
EPA. Additional program development studies have, in the
intervening three years, followed up on the workgroup's initial
conclusions and recommendations. The reports on these projects,
which represent subsequent updates and refinements of the
chemical selection process, are briefly described in the next
section.
20
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3. CHEMICAL SELECTION - SUBSEQUENT REPORTS
The original list of chemicals selected for further study
in 1987 continues to evolve as more research data become
available and new methodologies are developed. The projects
briefly described below represent the continuing refinement of
the chemical selection process.
3.1 FURTHER STUDY ON SELECTED CHEMICALS - DNA ADDUCTS:
The selected chemicals for further study have become the
subject of a report prepared by Oak Ridge National Laboratory
(Uziel et al., 1989). In this report, the research database is
reviewed and summarized for nine of the highest priority
chemicals listed in Table 1, as well as for 3 benzidine-based
dyes.
In the case of in vitro and validated animal studies, the
Oak Ridge report provides information relating to biological
media, species, the chronic or acute nature of the exposure
(i.e., continuous exposure, single dose, multiple dose, etc.) and
dose response data. In addition, specific attention is directed
towards applicability for use in a human monitoring study.
Potentially exposed populations are identified and the expected
routes, levels, and duration of exposure are estimated.
3.2 FURTHER STUDY OF SELECTED CHEMICALS - PROTEIN ADDUCTS:
In the 1987 report entitled "Carcinogen-DNA Adducts:
Introduction, Literature Summary and Recommendations" (Soileau,
1987), it was recognized that hemoglobin and serum albumin4
adducts may be more advantageous than DNA adducts as biological
markers of exposure, because the protein adducts are more stable
and are accessible from humans in much larger quantities. As
indicated in the previous chapter, several of the candidate
chemicals listed in Tables 1 and 2 were not known to form DNA
adducts, but were included in consideration of their potential to
form protein adducts.
In 1988, an internal U.S.EPA report entitled "Protein
Adduct-Forming Chemicals For Exposure Monitoring: Literature
Summary and Recommendations" summarized the literature regarding
adducts formed by xenobiotics with proteins, particularly
hemoglobin and serum albumin, and examined the feasibility of
their use as dosimeters of exposure. Conclusions were drawn and
proposals made with respect to those compounds, protein adducts
and detection methods best suited to monitoring human exposure
to toxic chemicals, particularly those occurring at Superfund
sites and others of interest to the EPA. This report was updated
and upgraded to an EPA project report in the following year
(Schnell, 1990). The recommended chemicals were ranked by their
potential for exposure monitoring using protein adduct-based
methods (Table 3).
21
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Table 3. PRIORITIZED LIST OF PROTEIN ADDUCT-FORMING
COMPOUNDS OF INTEREST TO THE EPA
Group I - Simple alkylating and arylating agents
that form N-terminal valine adducts
1) Ethylene Oxide
2) Propylene Oxide
3) Styrene
Group II - Aromatic amines that form hydrolyzable
cysteine adducts
1) 4-Aminobiphenyl
2) Benzidine
3) MOCA
4) o-Toluidine
Group III - Chemicals that form hydrolyzable, but
less well-characterized adducts
1) N-Nitrosonornicotine
2) Benzo[a]pyrene
3) 1-Nitropyrene
Group IV - Chemicals that form characterized,
but nonhydrolyzable adducts
1) Vinyl Chloride
2) Ethylene Dichloride
3) Acrylonitrile
4) Acrylamide
5) Chloroform
Group V - Chemicals that form poorly
characterized adducts
1) Benzene
2) Formaldehyde
3) 2,4-Toluene Diisocyanate
4) 7,12-Dimethylbenzanthracene
5) Epichlorhydrin
6) Benzyl Chloride
7) Pentachlorophenol
22
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In 1989, an expanded treatment of those chemicals
recommended for further study in the 1988 protein adducts report
was prepared as an EPA project report (Schnell, 1989) . The
topics covered for each individual chemical were: manufacture and
use, sources and levels of exposure, known health effects,
metabolic detoxification and activation, host factors, adduct
characterization, rates of adduct formation (i.e., second order
rate constants), dose-response relationships, background adduct
levels, methods of adduct detection, and research needs.
3.3 COMPUTERIZED PROTEIN ADDUCT PROFILES -
In 1990, a Computerized Protein Adducts Database (CPAD)
was created to provide an efficient means of updating and
disseminating information on protein adducts as regards their
utility as dosimeters of exposure to environmental contaminants,
especially genotoxic and/or carcinogenic compounds. The
structure of the database as well as its initial contents were
derived primarily from the document, "Protein Adduct-Forming
Chemicals for Exposure Monitoring: Chemicals for Further Study"
(EPA/600/4-89/035). The programs that enable the user to search,
modify, or update the database and display its contents were
originally written in the DBASE III PLUS programming language,
then converted, compiled and linked by DBASE IV. The final
product is a user-friendly, menu-driven, stand-alone DBASE
application that can be accessed by anyone with virtually no
previous training. For information on the availability of this
database, contact Charles H. Nauman at the following address:
United States Environmental Protection Agency, Environmental
Monitoring Systems Laboratory, Exposure assessment Research
Division, P.O. Box 93478, Las Vegas, Nv., 89193-3478.
23
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REFERENCES
ATSDR (1988a). Toxicological Profile for Chloroform
(PB-89160360). Agency for Toxic Substances and Disease
Registry.
ATSDR (1988b). Toxicological Profile for Benzene (PB-89209464).
Agency for Toxic Substances and Disease Registry.
ATSDR (1989a). Toxicological Profile for Benzidine
(PB-90168204). Agency for Toxic Substances and Disease
Registry.
ATSDR (1989b). Toxicological Profile for Vinyl chloride
(PB-90103870). Agency for Toxic Substances and Disease
Registry.
ATSDR (1989c). Toxicological Profile on Pentachlorophenol
(PB-90182163). Agency for Toxic Substances and Disease
Registry.
ATSDR (1989d). Toxicological Profile on 1,2-Dichloroethane
(PB-90171422). Agency for Toxic Substances and Disease
Registry.
Beland, F.A., B.T. Beranek, K.L. Dooley, R.H. Heflich, and F.F.
Kadlubar (1983). Arylamine DNA adducts in vitro and in vivo;
their role in bacterial mutagenesis and urinary bladder
carcinogenesis. Environ. Health Perspect., 49:125-134.
Beland, F.A. and F.F. Kadlubar (1985). Formation and presistence
of arylamine DNA adducts in vivo. Environ. Health Perspect.,
62:19-30.
Birner, G., W. Albrecht, and H.G. Neumann (1990). Biomonitoring
of aromatic amines. Ill: Hemoglobin binding of benzidine and
some benzidine congeners. Arch. Toxicol. (West Germany),
64(2):97-102.
Bryant, M.S., P.L. Skipper, S.R. Tannenbaum, and M. Maclure
(1987). Hemoglobin adducts of 4-aminobiphenyl in smokers and
non-smokers. Cancer Res., 47:602-608.
Bryant, M., P. Vineis, P. Skipper, and S. Tannenbaum (1988).
Hemoglobin adducts of aromatic amines: Associations with
smoking status and type of tobacco. Proc. Natl. Acad. Sci.
USA, 85:9788-9791.
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Calleman, C.J., Ehrenberg, L., Jansson, B., Osterman-Golkar, S.,
Segerback, D., Svensson, K., and Wachtmeister, C.A. (1978).
Monitoring and risk assessment by means of alkyl groups in
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Carmella, S.G., and S.S.Hecht (1987). Formation of hemoglobin
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nitrosamines 4-(methylnitrosamino)-1- (3-pyridyl)- 1-butanone
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Farmer, P.B., Bailey, E., Gorf, S.M., Tornqvist, M., Osterman-
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Monitoring human exposure to ethylene oxide by determination
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Garrett, N. E., H. F. Stack, M. R. Gross and M. D. Waters (1984).
An analysis of the spectra of genetic activity produced by
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Garrett, N. E., H. F. Stack and M. D. Waters (1986). Evaluation
of the genetic activity profiles of 65 pesticides, Mutat.
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Groopman, J.D. (1987). DNA adducts of nitropyrene detected by
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Guengerich, F.P., L.A. Peterson, J.L. Cmarik, N. Koga, and P.B.
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Harris, Curtis C., Kirsi Vahakangas, Mark J. Newman, Glenwood E.
Trivers, Abulkalam Shamsuddin, Nuntia Sinopoli, Dean L. Mann
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diol epoxide-DNA adducts in peripheral blood lymphocytes and
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25
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Henuninki, K., A. Alhonen-Raatesalmi, P. Koivisto, and P. Vodicka
(1990). Synthesis and stability of 2'-deoxyguanosine 3'-
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Hemminki, K., K. Savela, E. Linkola, and A. Hesso (1988).
Detection of DNA adducts by postlabelling with 3H-acetic
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Hemminki, K. (1986). Binding of styrene oxide to amino acids,
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Cancer, Lyon, France.
26
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Jackson, M.A., L.C. King, L.M. Ball, S. Ghayourmanesh, A.M.
Jeffrey, and J. Lewtas (1985). Nitropyrene: DNA binding and
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Kennelly, J.C., F.A. Beland, F.F. Kadlubar, and C.N. Martin
(1984). Binding of N-acetylbenzidine and N,N'-diacetyl-
benzidine to hepatic DNA of rat and hamster in vivo and in
vitro. Carcinogenesis, 5:407-412.
Kuslikis, B.I., T.H. Chen, and W.E. Braselton (1988). Syntheses
of N-oxidized derivatives of 4,4'-methylenebis(2-chloro-
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Lee, Byung Mu, and R.M. Santella (1988). Quantitation of protein
adducts as a marker of genotoxic exposure: immunologic
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Maclure, M., M.S. Bryant, P.L. Skipper, and S.R. Tannenbaum
(1990). Decline of the hemoglobin adduct of 4-amino- biphenyl
during withdrawal from smoking. Cancer Res., 50(1):181-184.
Maclure, M., R.B. Katz, M.S. Bryant, P.L. Skipper, and
S.R.Tannenbaum (1989). Elevated blood levels of carcinogens
in passive smokers. Am. J. Public Health, 79(10):1381-1384.
Manis, M.O., D.E. Williams, K.M. McCormack, R.J. Schock, L.F.
Lepper, Y. Ng, and W.E. Braselton Jr. (1984). Percutaneous
absorption, disposition and excretion of 4,4'-methylene
bis(2-chloroaniline) in dogs. Environ. Res., 33:234-245.
Martin, C.N., and S.F. Ekers (1980). Studies on the macromolecular
binding of benzidine. Carcinogenesis, 1:101-109.
Martin, C.N., F.A. Beland, R.W. Roth, and F.F. Kadlubar (1982).
Covalent binding of benzidine, N-acetylbenzidine, to DNA at
the C-8 atom of deoxyguanosine in vitro and in vivo. Cancer
Res., 42:2678-2686.
Martin, C.N., F.A. Beland, J.C. Kennelly, and F.F. Kadlubar
(1983). Binding of benzidine, N-acetylbenzidine,
N,N'diacetylbenzidine and direct blue 6 to rat liver DNA.
nviron. Health Perspect. 49:101-106.
Martin, Carl. N., and James C. Kennelly (1985). Metabolism,
mutagenicity, and DNA binding of Biphenyl-based azodyes. Drug
Metab. Rev., 16:89-117.
27
-------
Mitchum, R.K., J.P. Freeman, F.A. Beland, and F.F. Kadlubar
(1985). Mass spectrometric identification of DNA adducts
formed by carcinogenic aromatic amines. Anal. Chem. Symp.
Ser. 24:547-580.
NTP (1985). Fourth Annual Report on Carcinogens, published by the
U.S. Department of Health and Human Services.
Osterman-Golkar, S. (1983). Tissue Doses in Man: Implications in
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Eds., Elsevier, pp. 289-298.
Osterman-Golkar, S., and E. Bergmark (1988). Alkylation of
hemoglobin, plasma proteins and DNA in the mouse by diethyl-
nitrosamine. Carcinogenesis, 9:1915-1917.
Passingham, B. J., P. B. Farmer, E. Bailey, A.G.F. Brooks, and D.
W. Yates (1987). 2-Hydroxyethylation of haemoglobin in man.
IARC Sci Publ (France) 89:279-285.
Pereira, M.A., and L.W. Chang (1982). Binding of chloroform to
mouse and rat hemoglobin. Chem. Biol. Interact., 39:89-99.
Perera, F.P., R.M. Santella, D. Brenner, M.C. Poirier, A.A.
Munshi, H.K. Fischman, and J. Van Ryzin (1987). DNA adducts,
protein adducts, and sister chromatid exchanges in cigarette
smokers and non-smokers. J. Nat. Cancer Instit., 79:449-456.
Phillips, David H., Kari Hemminki, Anneli Alhonen, Alan Hewer and
Phillip Grover (1988). Monitoring occupational exposure to
carcinogens: detection by 32P-postlabelling of aromatic DNA
adducts in white blood cells from iron foundry workers.
Mutat. Res., 204:531-541.
Schnell, F.C. and T.C. Chiang (1989). Protein Adduct-Forming
Chemicals for Exposure Monitoring: Chemicals Selected for
Further Study. EPA/600/4-89/035.
Schnell, F.C.and T.C. Chiang (1990). Protein Adduct-Forming
Chemicals for Exposure Monitoring: Literature Summary, and
Recommendations. EPA/600/4-90/007.
Segerback, D. (1983) . Alkylation of DNA and Hemoglobin in the
Mouse Following Exposure to Ethene and Ethene Oxide. Chem.
Biol. Interact., 45:139-151.
28
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Skipper , Paul L., Mieczyslaw W. Obiedzinski, Steven R.
Tannenbaum, Dwight W. Miller, Ronald K. Mitchum and Fred F.
Kadlubar (1985). Identification of the major serum albumin
adduct formed by 4-aminobiphenyl in vivo in rats. Cancer
Research, 45:5122-5127.
Soileau, S.D. (1987). Carcinogen-DNA Adducts: Introduction,
Summary, and Recommendations. U.S. EPA Project Report,
EPA/600/4-87/005.
Svensson, K., and S. Osterman-Golkar (1986). Covalent binding of
reactive intermediates to hemoglobin in the mouse as an
approach to studying the metabolic pathways of
1,2-dichloroethane. IARC Scientific Publication, 70:269-279
Swenberg, J.A., H. d'A. Heck, K.T. Morgan, and T.B. Starr (1985).
A scientific approach to formaldehyde risk assessment.
Banbury Report, 19:255-267.
Talaska, Glenn, William W. Au, Jonathan B. Ward, Jr., Kurt
Randerath, and Marvin S. Legator (1987). The correlation
between DNA adducts and chromosomal aberrations in the target
organ of benzidine exposed, partially-hepatectomized mice.
Carcinogenesis, 12:1899-1905.
Tannenbaum, S.R., Mathew S.Bryant, Paul L.Skipper, and Malcolm
Maclure (1986) , Hemoglobin adducts of Tobacco-related aromatic
amines: application to molecular epidemiology, pp. 63-75 in:
Banbury report #23, Mechanisms of Tobacco Carcinogenesis, Cold
Spring Harbor.
Tornqvist, M., S. Osterman-Golkar, A. Kautiainen, S. Jensen, P.
B. Farmer, and L. Ehrenberg (1986). Tissue doses of ethylene
oxide in cigarette smokers determined from adduct levels in
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Tornqvist, M.A., J.G. Almberg, E.N. Bergmark, S. Nilsson, and
S.M. Osterman-Golkar (1989). Ethylene oxide doses in ethene-
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DNA Adduct Formation by Twelve Chemicals with Populations
Potentially Suitable for Molecular Epidemiological Studies.
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selected organic solvents. Scand. J. Work Environ. Health
ll(suppl. 1):75-82.
29
-------
Van Sittert, N.J., De Jong, G., Clare, M.G., Davies, R., Dean
B.J. Wren, L.J., and Wright, A.S (1985). Cytogenetic,
immunological and hematological effects in workers in an
ethylene oxide manufacturing plant. Br. J. Indust. Med.,
42:9-26.
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Glogowski, H.Bartsch, M. Coda, G. Talaska, and F. Kadlubar
(1990) . Acetylation phenotype, carcinogen-hemoglobin adducts,
and cigarette smoking. Cancer Res., 50(10):3002-3004.
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of styrene oxide in single- and double-stranded DNA. Chem.
Biol. Interact. 68(1-2):117-126.
Walles, S.A. (1981). Reaction of benzyl chloride with haemoglobin
and DNA in various organs of mice. Toxicol. Lett., 9: 379-387.
Waters, Michael D., and A. Auletta (1981). The Gene-Tox Program:
Genetic Activity Evaluation. J. Chem. Info. Comput. Sci.,
21:35-38.
Waters, Michael D., H. Frank Stack, and Ann L. Brady (1988).
Genetic Activity Profiles of Some Chemicals Found in Hazardous
Wastes, In: Hazardous Waste; Detection. Control. Treatment.
Elsevier Science Publishers, Amsterdam, 1988.
Waters, Michael D., H. Frank Stack, Ann L. Brady, Paul H.M.
Lohman, Lynne Haroun, and Harri Vanio (1988). Use of
Computerized Data Listings and Activity Profiles of Genetic
and Related Effects in the Review of 195 Compounds. Mutat.
Res. (Netherlands), 205(1-4):295-312.
Weston, A., M.L. Rowe, O.K. Manchester, P.B. Farmer, D.L. Mann,
and C.C. Harris (1989). Fluorescence and mass spectral
evidence for the formation of benzo[a]pyrene
anti-diol-epoxide-DNA and -hemoglobin adducts in humans.
Carcinogenesis, 10(2):251-257.
Wraith, M. J., W. P. Watson, C. V. Eadsford, N. J. Van Sittert,
and A. S. Wright (1987). An immunoassay for monitoring human
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Zeighami, E., M. Uziel, T. VoDinh, R. Haglund, L. Waters, and S.
Katz (1987). Human Populations Suitable for the Study of
Molecular Biomarkers of DNA Damage. U. S. EPA Project Report
(DRAFT), Health and Safety Research Division, Oak Ridge
National Laboratory.
30
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APPENDIX A
PRIORITIZED SOURCES OF CHEMICAL LISTS
1. Office of Toxic Substances List (OTS)
This list was obtained from the Existing Chemicals Division of the OTS. It is comprised of three
sublists obtained from each of the following branches: Test Rules Development, Chemical Screening, and
Risk Analyses. The combined list is abbreviated as "OTS".
2. Office of Air Quality Planning and Standards List (AIR)
This list contains those compounds of lexicological concern to the above office. This list is
abbreviated as "AIR".
3. Resource Conservation and Recovery Act (RCRA) Appendix Vlll - Hazardous Constituents (RR1)
This list of hazardous chemicals was taken from the 1986 Code of Federal Regulations, Volume 40, Part
261. Note that the CRF is published yearly, so additions to the list or deletions (Appendix IX) can
be noted. This list is abbreviated as "RR1".
Refinery Waste List (RWL)
This list is from the Office of Solid Waste dated April 1986 and is a subset of the Appendix VIII list
that contains potential hazardous chemicals that may be present in refinery waste. This list is
abbreviated as "RWL".
Office of Solid Waste List (OSW)
This list was from the Office of Solid Waste and is abbreviated as "OSW".
4. Comprehensive Environmental Response Compensation and Liability Act (CERCLA) Hazardous Substance List
(HSL)
This list of hazardous chemicals was taken from the 1986 Code of Federal Regulations, Volume 40, Part
302.4. (See note in 3). This list is abbreviated as "HSL".
Acutely Toxic Chemicals List (ACUTE)
The list of chemicals was located under Title III of the Superfund Amendments and Reauthorization Act
of 1986, as described in the Federal Register, Volume 51, Number 221, pages 41582-41587. This list is
known as the list of extremely hazardous substances. This list of chemicals is abbreviated as "ACUTE".
New Jersey List of Chemicals (NJ)
This list of chemicals was found in section 313 of Title III of the Superfund Amendments and
Reauthorization Act of 1986. This list is abbreviated as "NJ".
Clean Water Act Chemicals List (SF)
This list of chemicals and approved methods for analysis of waste water was located in the Federal
Register, Volume 49, pages 23-25. This list is abbreviated as "SF".
Superfund Ammendments and Reauthorization Act List (SARA)
This list of chemicals was found in the Federal Register, Volume 52, No. 74, April 17, 1987, pages
12866-12874. This list consists of at least 100 hazardous substances which are most commonly found at
National Priorities List facilities and thought to pose the most significant potential threat to human
health. This list is abbreviated as "SAR".
A-1
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APPENDIX A (continued)
5. Ground Water list (GUI.)
This list is the RCRA Appendix IV Ground Water Monitoring List. This list is abbreviated as "GUI".
Office of Solid Waste List for Water (H20)
This list was obtained from Dave Friedman of the Office of Solid Waste in June of 1986. The list
contains chemicals found in water for which no suitable method of analysis exists. This list is
abbreviated as "H20".
6. Joint Office of Drinking H20 and Office of Pesticide Programs list (OPP)
This is a list of compounds that will be tested in ground water in a project jointly sponsored by the
aforementioned program offices. This list is abbreviated as "OPP".
A-2
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APPENDIX B
PRIORITIZED LIST OF CHEMICALS OF INTEREST TO THE EPA
REC # / CHEMICAL
CASNUM
SOURCE
P1 P2
1 BENZENE 00071-43-2
2 METHYLENE CHLORIDE 00075-09-2
3 VINYL CHLORIDE 00075-01-4
4 1,1-DICHLOROETHENE 00075-35-4
5 1,3-DICHLOROBEMZENE 00541-73-1
6 1,4-DICHLOROBENZENE 00106-46-7
7 ETHYLENE DICHLORIDE 00107-06-2
8 ETHYLENE OXIDE 00075-21-8
9 FORMALDEHYDE 00050-00-0
10 HEXACHLOR08ENZENE 001.18-74-1
11 HEXACHLOROBUTADIENE 00087-68-3
12 NAPHTHALENE 00091-20-3
13 TETRACHLOROETHENE 00127-18-4
14 TOLUENE 00108-88-3
15 BROMOMETHANE 00074-83-9
16 CARBON TETRACHLORIDE 00056-23-5
17 CHLOR08ENZENE 00108-90-7
18 TRICHLOROETHANE 00071-55-6
19 TRICHLOROETHYLENE 00079-01-6
20 1,2,4-TRICHLOROBENZENE 00120-82-1
21 DI-N-BUTYL PHTHALATE 00084-74-2
22 DIMETHYL PHTHALATE 00131-11-3
23 NITROBENZENE 00098-95-3
24 PENTACHLOROPHENOL 00087-86-5
25 1,2-DICHLOROBENZENE 00095-50-1
26 2,4-DICHLOROPHENOXYACETIC ACID 00094-75-7
27 4-NITROPHENOL 00100-02-7
28 CHLOROFORM 00067-66-3
29 EHDR1N 00072-20-8
30 ANILINE 00062-53-3
31 BIS(2-ETHYLHEXYL)PHTHALATE 00117-81-7
32 CHLOROMETHANE 00074-87-3
33 HEXACHLOROETHANE 00067-72-1
34 METHOXYCHLOR 00072-43-5
35 TRIBROMOMETHANE 00075-25-2
36 1,1,2.2-TETRACHLOROETHANE 00079-34-5
37 1,1,2-TRICHLOROETHANE 00079-00-5
38 1,1-DICHLOROETHANE 00075-34-3
39 1,2-DIBROMOETHAHE 00106-93-4
40 ALDRIN 00309-00-2
41 ANTIMONY 07440-36-0
42 ARSENIC 07440-38-2
43 BERYLLIUM 07440-41-7
44 CADMIUM 07440-43-9
45 CHLOROETHANE 00075-00-3
46 CHROMIUM 07440-47-3
47 DICHLOROPROPANE 00078-87-5
48 DIETHYL PHTHALATE 00084-66-2
49 DISULFOTON 00298-04-4
50 HEPTACHLOR 00076-44-8
51 HEPTACHLOR EPOXIDE 01024-57-3
52 METHYL ETHYL KETONE 00078-93-3
53 N-NITROSOOIMETHYLAMINE 00062-75-9
54 P-NITROAHILINE 00100-01-6
55 PYRIDINE 00110-86-1
56 SELENIUM AND COMPOUNDS 07782-49-2
57 1.2-DIBROMO-3-CHLOROPROPANE 00096-12-8
58 2.4,5-T 00093-76-5
59 4,4'-DDE 00072-55-9
AIR,GUL,HSL,NJ,OPP,OTS,RR1,RWL,SF,SAR 6 4
AIR,GUL,HSL,NJ,OPP,OTS,RR1,RUL,SF,SAR 6 4
AIR,GUL,HSL,NJ,OPP,OTS,RR1,SF,SAR 6 3
GUL,HSL,NJ,OPP,OTS,RR1,RWL,SF,SAR 5 4
GUL,HSL,NJ,OPP,OTS,OUS,RR1,SF,SAR 5 4
GUL,H20,NJ,OPP,OTS,OUS,RR1,SF,SAR 5 4
AIR,GVL,HSL,NJ,OPP,RR1,RUL,SF,SAR 5 4
AC,AIR,GWL,HSL,NJ,OTS,RR1,RUL,SAR 5 4
AC,AIR,H20,HSL,NJ,OTS,RR1.RWL>SAR 5 4
H20,GWL,HSL,NJ,OPP,OTS,RR1,SF,SAR 5 4
GUL,H20,HSL,NJ,OPP,OTS,RR1,SF,SAR 5 4
GUL,H20,NJ,OPP,OTS,OWS,RR1,SF,SAR 5 4
AIR,GUL,HSL,NJ,OPP,RR1,RUL,SF,SAR 5 4
GUL,HSL,NJ,OPP,OTS,RR1,RUL,SF,SAR 5 4
AC,GWL,HSL,OPP,OTS,RR1,SF,SAR 5 3
A1R,GWL,HSL,NJ,OPP,RR1,SF,SAR 5 3
GUL,HSL,NJ,OPP,OTS,RUL,SF,SAR 5 3
GWL,HSL,NJ,OPP,OTS,RR1,SF,SAR 5 3
AIR,GUL,HSL,NJ,OPP,RR1,SF,SAR 5 3
GWL,HSL,NJ,OPP,OTS,RR1,SF 5 2
AC,GUL,HSL,NJ,OTS,OUS,RR1,RWL,SF,SAR 4 6
AC,GUL,HSL,NJ,OTS,OUS,RR1,RUL,SF,SAR 4 6
AC,GUL,H20,HSL,NJ,OTS(RR1,RWL,SF,SAR 4 6
AC,GUL>H20,HSL,NJ,OPP,RR1,RUL,SF,SAR 4 6
H20,GUL.HSL,NJ,OPP,OUS,RR1,SF,SAR 4 5
GUL,H20,HSL,NJ,OPP,OUS,RR1,SF,SAR 4 5
GWL,HSL,NJ,OPP,OUS,RR1,RUL,SAR 4 5
AC,AIR,GUL,HSL,NJ,RR1,RUL,SF,SAR 4 5
AC,GUL,H20,HSL,OPP,OUS,RR1,SF,SAR 4 5
AC,GUL.HSL,NJ,OTS,RR1,RWL,SAR 4 4
GUL,HSL.NJ,OTS,RR1,RWL,SF,SAR 4 4
GUL,HSL,NJ,OTS,RR1,RUL,SF,SAR 4 4
GUL,H20,HSL,NJ,OTS,RR1,SF,SAR 4 4
GUL,H20,HSL,HJ,OPP,RR1,SF,SAR 4 4
GUL,HSL,NJ,OPP,OWS,RR1,SF,SAR 4 4
GUL,HSL,NJ.OPP,RR1,SF,SAR . 4 3
HSL,GUL,NJ.OPP,RR1,SF,SAR 4 3
GUL,HSL,OPP,OUS,RR1,SF,SAR 4 3
GUL,HSL,NJ,OPP,RR1,RUL,SAR 4 3
AC,GUL,NJ,OPP,RR1,SF,SAR 4 3
GUL,HSL,NJ,OTS,RR1,RUL,SAR 4 3
AIR,GUL,HSL,NJ,RR1,RUL,SAR 4 3
AIR,GWL,HSL,NJ,RR1,RUL,SAR 4 3
AIR.GUL,HSL,HJ,RR1,RUL,SAR 4 3
AIR,GWL,HSL,NJ,OPP,SF,SAR 4 3
AIR,GWL,HSL,NJ,RR1,RWL,SAR 4 3
GUL,HSL,NJ,OTS,RR1,SF,SAR 4 3
GWL,HSL,NJ.OTS,RR1,RUL,SAR 4 3
AC,GUL,HSL.OPP,RR1,SF,SAR 4 3
GWL,HSL,NJ,OPP,RR1,SF,SAR 4 3
GWL,H20,HSL,OPP,RR1,SF,SAR 4 3
GVL,HSL,NJ,OTS,RR1,RUL,SF,SAR 4 3
AC,GUL.HSL,NJ,OTS,RR1,SAR 4 3
GWL.HSL,OTS,OUS,RR1,RUL,SF 4 3
GUL,H20,HSL,NJ.OTS,RR1,RUL 4 3
AIR,GWL,HSL,NJ,RR1,RUL,SAR 4 3
GUL,HSL,NJ,OPP,RR1,SAR 4 2
GUL,HSL,OPP,RR1,SF,SAR 4 2
GUL,HSL,OPP,RR1,SF,SAR 4 2
B-1
-------
Appendix B (continued)
REC # / CHEMICAL
CASNUM
SOURCE
P1 P2
60 ACETONITRILE 00075-05-8
61 ACRYLAM1DE 00079-06-1
62 BENZ(A)ANTHRACENE 00056-55-3
63 DIBROMOMETHANE 00074-95-3
64 DIELDRIN 00060-57-1
65 MERCURY 07439-97-6
66 METHYL 1SOCYANATE 00624-83-9
67 METHYL METHACRYLATE 00080-62-6
68 P-8ENZOOUINONE 00106-51-4
69 P-CHLOROANILINE 00106-47-8
70 PENTACHLOROETHANE 00076-01-7
71 STYRENE 00100-42-5
72 4,4'-ODD 00072-54-8
73 ASBESTOS 01332-21-4
74 CHLOROBENZILATE 00510-15-6
75 DICHLORCOIFLUOROMETHANE 00075-71-8
76 DtNOSEB 00088-85-7
77 GLYCIDALDEHYOE 00765-34-4
78 MALEIC ANHYRIOE 00108-31-6
79 N-NITROSODI-N-BUTYLAMINE 00924-16-3
80 N-NITROSODIETHYLAMINE 00055-18-5
81 SILVEX 00093-22-1
82 TRANS-1.2-DICHLOROETHENE 00156-60-5
83 TRICHLOROMONOFLUOROMETHANE 00075-69-4
84 1,1,1,2-TETRACHLOROETHANE 00630-20-6
85 1,2,3-TRICHLOROPROPANE 00096-18-4
86 1,2,4,5-TETRACHLOROBENZENE 00095-94-3
87 2-CHLORO-1,3-BUTADIENE 00126-99-8
88 N-NITROSOMORPHOLINE 00059-89-2
89 PRONAMIDE 23950-58-5
90 TRANS-1,4-DICHLOROBUTENE 00110-57-6
91 PHENOL 00108-95-2
92 0-CRESOL 00095-48-7
93 ACRYLONITRILE 00107-13-1
94 CARBON BISULFIDE 00075-15-0
95 DICHLOROETHYL ETHER 00111-44-4
96 DINITROTOLUENE 00121-14-2
97 DIOCTYL PHTHALATE 00117-84-0
98 LINOANE 00058-89-9
99 TOXAPHENE 08001-35-2
100 2,4,5-TRICHLOROPHENOL 00095-95-4
101 2,4,6-TRICHLOROPHENOL 00088-06-2
102 2,4-OIMETHYLPHENOL 00105-67-9
103 2,4-OINITROPHENOL . 00051-28-5
104 ACROLEIN 00107-02-8
105 CHLORDANE 00057-74-9
106 HEXACHLOROCYCLOPENTAOIENE 00077-47-4
107 NICKEL 07440-02-0
108 P-CRESOL 00106-44-5
109 PARATHION 00056-38-2
110 PHOSGENE 00075-44-5
111 VINYL ACETATE MONOMER 00108-05-4
112 1,2-DIPHENYL HYDRA2INE 00122-66-7
113 1,4 DIOXANE 00123-91-1
114 2,4-OICHLOROPHENOL 00120-83-2
115 2-CHLORONAPHTHALENE 00091-58-7
116 2-CHLOROPHENOL 00095-57-8
117 3,3>-DICHLOROBENZIDINE 00091-94-1
118 4-BROMOPHENYL PHENYL ETHER 00101-55-3
119 4-METHYL-2-PENTANONE 00108-10-1
120 8ENZIOINE 00092-87-5
121 8ENZO(A)PYRENE 00050-32-8
GWL,HSL,NJ,OTS,RR1,RWL
AC,AIR,HSL,NJ,OTS,RR1
GWL,HSL,RR1,RUL,SF,SAR
GUL,HSL,NJ,OPP,OUS,RR1
GUL,HSL,OPP,RR1,SF,SAR
AIR,GUL,HSL,NJ,RR1,SAR
AC,A1R,HSL,NJ,OTS,RR1
AIR,GUL,HSL,NJ,RR1,SAR
GUL,HSL,NJ,OTS,OUS,RR1
GUL,HSL,OTS,RR1,SF,SAR
AC,GUL,HSL,OTS,OWS,RR1
AIR,GUL,HSL,HJ,OPP,SF
GWL,OPP,RR1,SF,SAR
AIR,HSL,NJ.OTS,SAR
GWL,HSL,NJ,OPP,RR1
GWL,HSL,OPP,RR1,SAR
AC,GUL,HSL,OPP,RR1
H20,HSL,OTS,OWS,RR1
AIR,NJ,OTS,OUS,RR1
GUL,HSL,NJ,OTS,RR1
GWL,HSL,NJ,OTS,RR1
GUL,H20,OPP,RR1
GUL,HSL,OPP,RR1,RWL
GUL,HSL,OPP,RR1,SAR
GUL.HSL.OPP.RRI
GUL,OPP,RR1,SAR
GUL,HSL,OTS,RR1
GUL,NJ,OTS,RR1
GUL,NJ,OTS,RR1
GUL.HSL.OPP.RRI
AC.GUL.OTS.RR1
AC,GUL,H20,HSL,NJ,RR1,RUL,SF,SAR
AC,GUL,H20,HSL,NJ,OTS,SF,SAR
AC,GUL,HSL,NJ,OTS,RR1,RUL,SAR
AC.GUL.HSL.MJ.RRI.RUL.SF.SAR
AC,GUL,HSL,NJ,RR1,RUL,SF,SAR
GUL,H20,HSL,NJ,RR1,RUL,SF,SAR
AC,GWL,HSL,NJ,RRA,RWL,SF,SAR
AC,GUL,H20,HSL,NJ,OPP,SF,SAR
AC,GUL,H20,HSL,HJ,RR1,SF,SAR
GWL,H20,HSL,NJ,RR1,SF,SAR
GUL,H20,HSL,NJ,RR1,SF,SAR
GUL,HSL,MJ,RR1,RUL,SF,SAR
GUL,HSL,NJ,RR1,RUL,SF,SAR
AC,GUL,HSL,MJ,RR1,RUL,SAR
AC,GWL,H20,HSL,NJ,RR1,SAR
AC,GUL,HSL,NJ,OTS,SF,SAR
AC,GUL,HSL,NJ,RR1,RUL,SAR
GUL,H20,HSL,NJ,OTS,SF,SAR
AC,GUL,HSL,NJ,RR1,SF,SAR
AC,AIR,HSL,NJ,OUS,RR1,SAR
AC,GUL,HSL,NJ,OTS,SF,SAR
GUL,HSL,NJ,RR1,RUL,SAR
GWL,HSL,NJ,RR1,RWL,SAR
GUL.HSL.NJ.RRI.SF.SAR
GUL,HSL,RR1,RUL,SF
GWL,HSL,RR1,RWL,SF,SAR
GWL,HSL,NJ,RR1,SF,SAR
GUL,HSL,OWS,RR1,SF,SAR
GUL,HSL,NJ,OTS,SF,SAR
GUL,HSL,NJ,RR1,RUL,SAR
GUL,HSL,RR1,RUL,SF,SAR
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
0
0
0
0
0
0
0
6
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
B-2
-------
Appendix B (continued)
REC #
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
/ CHEMICAL
BENZO(B)FLUORANTHENE
BIS(2)CHLOROISOPROPYL ETHER
B1S(2-CHLOROETHOXY)METHANE
BROMOOICHLOROMETHANE
CHRYSENE
CYANIDE
DOT
DI-N-PROPYLNITROSAMINE
DIBENZCA.HJANTHRACENE
ETHYL BENZENE
FLUORANTHENE
HYORAZINE
HYDROGEN SULF1DE
INDENO(1,2,3)PYRENE
LEAD
METHYL MERCAPTAN
P-CHLORO-M-CRESOL
1-NAPHTHYLAMINE
2,6-OINITROTOLUENE
2-CHLOROETHYL VINYL ETHER
3-CHLORO-PROPIONITRILE
4,4METHYLENEBIS(2CHLOROANILINE
ACETONE CYANOHYDRIN
ALPHA-BHC
BARIUM
BETA-BHC
CHLOROOIBROMOMETHANE
DELTA-BHC
DIBENZOFURAN
DIMETHYLHYDRIZINE
ENDRIN ALDEHYDE
EPICHLOROHYDRIN
HYDROCYANIC ACID
HYDROGEN FLUORIDE
ISOOR1N
ISOPHORONE
M-XYLENE
MALONONITRILE
METHACRYLONITRILE
METHYL PARATH10N
METHYLHYDRAZINE
MUSTARD GAS
0-XYLENE
P-XYLENE
PENTACHLOROBENZENE
PENTACHLORON I TROBENZENE
PHTHAL1C ANHYDRIDE
SACCHARIN
SILVER
SULFOTEP
THALLIUM
THIOPHENOL
TOLUIDINE-0 HCL
1,2,4-TRlMETHYL BENZENE
1,3,5-TRINITROBENZENE
1-ENDOSULFAN
11-ENDOSULFAN
2,3,4 , 6-TETRACHLOROPHENOL
2.3,7,8-TETRACHLOR001BENZO-P-
2-NAPHTHYLAMINE
2-NITROANILINE
CASNUM
00205-99-2
00108-60-1
00111-91-1
00075-27-4
00218-01-9
00057-12-5
00050-29-3
00621-64-7
00053-70-3
00100-41-4
00206-44-0
00302-01-2
07783-06-4
00193-39-5
07439-92-1
00074-93-1
00059-50-7
00134-32-7
00606-20-2
00110-75-8
00542-76-7
00101-14-4
00075-86-5
00319-84-6
07440-39-3
00319-85-7
00124-48-1
00319-86-8
00132-64-9
00057-14-7
07421-93-4
00106-89-8
00074-90-8
07664-39-3
00465-73-6
00078-59-1
00108-38-3
00109-77-3
00126-98-7
00298-00-0
00060-34-4
00505-60-2
00095-47-6
00106-42-3
00608-93-5
00082-68-8
00085-44-9
00081-0702
07440-22-4
03689-24-5
07440-28-0
00108-98-5
00636-21-5
00095-63-6
00099-35-4
00959-28-8
22313-65-9
00058-90-2
01746-01-6
00091-59-8
00088-74-4
SOURCE
GUL,HSL,RR1,RUL,SF,SAR
GUL,HSL,NJ,OUS,RR1,RUL
GWL,HSL,OUS,RR1,SF,SAR
GWL,HSL,NJ,OPP,SF,SAR
GWL,HSL,RR1,RUL,SF,SAR
GWL,HSL,NJ,RR1,RWL,SAR
GUL,HSL,RR1,SF,SAR
GWL,HSL,NJ,RR1,SF,SAR
GUL,HSL,RR1,RWL,SF,SAR
GWL,HSL,NJ,OPP,SF,SAR
GUL,HSL,RR1,RWL,SF,SAR
AC,H20,HSL,NJ,RR1,SAR
AC,AIR,HSL,RR1,RUL,SAR
GUL,HSL,RR1,RUL,SF,SAR
GWL,HSL,NJ,RR1,RWL,SAR
AC,H20,HSL,OUS,RR1,RUL
GUL,HSL,RR1,RWL,SF,SAR
GUL,HSL,NJ,OWS,RR1
GUL,NJ,OUS,RR1,SF,SAR
GWL,HSL,OWS,RR1,SAR
AC,GUL,HSL,OUS,RR1
GUL,HSL,NJ,RR1,SAR
AC,H20,HSL,RR1,SAR
GWL,HSL,OPP,SF,SAR
GUL,NJ,RR1,RUL,sar
GUL,HSL,OPP,SF,SAR
GUL,HSL,OPP,SF,SAR
GUL,HSL,OPP,SF,SAR
AIR,GWL,NJ,SF,SAR
AC,H20,HSL,NJ,RR1
GUL,HSL,OPP,SF,SAR
AC,HSL,NJ,OTS,RR1
AC,AIR,HSL,NJ,RR1
AC,AIR,HSL,NJ,RR1
AC.GWL,HSL,RR1fSF
GUL,HSL,OTS,SF,SAR
HSL.NJ.OPP.OTS.SAR
AC,GUL,HSL,OWS,RR1
AC,GWL,HSL,OWS,RR1
AC,GUL,HSL,RR1,SF
AC,H20,HSL,NJ,RR1
AC,H20,NJ,RR1,SAR
HSL,NJ,OPP,OTS,SAR
HSL,NJ,OPP,OTS,SAR
GUL,HSL,OUS,RR1,SAR
GWL,HSL,NJ,RR1,SF
AIR,HSL,NJ,OUS,RR1
H20,HSL,NJ,OWS,RR1
GUL,HSL,RR1,NJ,SAR
AC,GUL,HSL,OUS,RR1
GUL,HSL,NJ,RR1,SAR
AC,GUL,HSL,RR1,RWL
H20,HSL,NJ,OUS,RR1
AC,NJ,OPP,OTS
H20,HSL,RR1,SAR
GWL.HSL.OPP.SF
GUL,HSL,OPP,SF
GUL,H20,HSL,RR1
GUL,HSL,RR1,SAR
GUL,HSL,NJ,RR1
GUL,OTS,SF,SAR
P1
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
P2
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
B-3
-------
Appendix B (continued)
REC # / CHEMICAL
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
2-PICOLINE
3,3'-DIMETHOXYBENZIDINE
3-CHLOROPROPENE
3-METHYLCHLORANTHRENE
3-NITROANILE
7,12,DIMEWLBENZ
-------
Appendix B (continued)
REC #
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
/ CHEMICAL
OINITROCRESOL
2-MITROPHENOL
AMMONIA
ANTHRACENE
BENZAL CHLORIDE
CARBARYL
DIEPOXYBUTANE
ETHYLENEIMINE
FLUORENE
N-NITROSOOIPHENYLAMINE
PYRENE
XYLENES
2-CHLOROPHENYL THIOUREA
2-METHYLAZIRIOINE
ACENAPHTHYLENE
ACETONE
8ENZO(GHI}PERYLENE
BENZOdQFLUORANTHENE
BENZOIC ACID
CHLOROMETHYL METHYL ETHER
CHLOROPHENYL PHENYL ETHER
COBALT
COPPER
CRESOLS
CYANOGEN BROMIDE
DIMETHYL SULFATE
ENDOSULFAN
FLUOROACETAMIDE
MECHLORETHAMINE
METHANOL
METHIOCARB
METHYL CHLOROCARBONATE
NICOTINE
OSMIUM TETROXIDE
PHENANTHRENE
PHENYLTHIOUREA
THIOSEMICARBAZIDE
WARFARIN
ZINC
1.3- PROPANE SULTONE
1-PROPYLAMINE
2,4-DIAMINOTOLUENE
2-HEXANONE
2-METHYLNAPHITHALENE
2-NITROPROPANE
3-3'DIMETHYLBENZIDINE
4,6-DINITRO-O-CYCLOHEXYLPHENOL
ACRYLIC ACIO
ALUMINUM PHOSPHIDE
ANTU
ARAMITE
AROCLOR 1016
AROCLOR 1221
AROCLOR 1232
AROCLOR 1242
AROCLOR 1248
AROCLOR 1254
AROCLOR 1260
ARSENIC PENTOXIDE
ARSENOUS OXIDE
ATRAZINE
AURAMINE
CASNUM
00534-52-1
00088-75-5
07664-41-7
00120-12-7
00098-87-3
00063-25-2
01464-53-5
00151-56-4
00086-73-7
00086-30-6
00129-00-0
01330-20-7
05344-82-1
00075-55-8
00208-96-8
00067-64-1
00191-24-2
00207-08-9
00065-85-0
00107-30-2
07005-72-3
07440-48-4
07440-50-8
01319-77-3
00506-68-3
00077-78-1
00115-29-7
00640-19-7
00051-75-2
00067-56-1
02032-65-7
00079-22-1
00054-11-5
20816-12-0
00085-01-8
00103-85-5
00079-19-6
00081-81-2
07440-66-6
01120-71-4
00107-10-8
00095-80-7
00591-78-6
00091-57-6
00079-46-9
00119-93-7
00131-89-5
00079-10-7
20859-73-8
00086-88-4
00140-57-8
12674-11-2
11104-28-2
11141-16-5
53469-21-9
12672-29-6
11097-69-1
11096-82-5
01303-28-2
01327-53-3
01912-24-9
00492-80-8
SOURCE
AC,GUL,HSL,NJ,SF,SAR
GUL,HSL,NJ,SF,SAR
AC,AIR,HSL,NJ,SAR
GWL.HSL.NJ.SF.SARA
AC,HSL,NJ,OWS,RR1
HSL,NJ,OPP,SF,SAR
AC,HSL,NJ,OUS,RR1
AC,HSL,NJ,RR1,RUL
GUL,H20,HSL,SF,SAR
GWL,HSL,NJ,SF,SAR
AC,GUL,HSL,SF,SAR
AIR,GUL,HSL,NJ,SAR
AC,HSL,OUS,RR1
AC,HSL,NJ,RR1
GUL,HSL,SF,SAR
GUL,HSL,NJ.SF
GUL,HSL,SF,SAR
GWL,HSL,SF,SAR
GUL,HSL,SF,SAR
AC.HSL.NJ.RR1
GWL,HSL,SF,SARA
AC.GVL.NJ.SAR
GUL,HSL,NJ,SAR
HSL,NJ,OTS,SAR
AC,HSL,RR1,OWS
AC.HSL.NJ.RR1
AC,HSL,RR1,SAR
AC,HSL,OUS,RR1
AC,NJ,RR1,SAR
AIR,HSL,NJ,SAR
AC,HSL,OPP,SF
AC,HSL,OWS,RR1
AC.HSL.OUS.RR1
AC,HSL,NJ,RR1
GWL,HSL,SF,SAR
AC,HSL,OUS,RR1
AC,HSL,OWS,RR1
AC,HSL,RR1,RWL
GWL,HSL,NJ,SAR
HSL,NJ,RR1
HSL,OUS,RR1
HSL.OTS.NJ
GWL.SF.SAR
GWL.SF.SAR
HSL.NJ.OTS
HSL.NJ.RR1
HSL.OWS.RR1
HSL.NJ.OTS
AC.HSL.RR1
AC.HSL.RR1
GUL.RR1.SAR
GWL.HSL.SF
GWL.HSL.SF
GWL.HSL.SF
GUL.HSL.SF
GWL.HSL.SF
GWL.HSL.SF
GUL.HSL.SF
AC.HSL.RR1
AC.HSL.RR1
OPP.SF.SAR
HSL.NJ.RR1
P1
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
P2
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
B-5
-------
Appendix B (continued)
REC
307
308
309
310
311
312
313
3U
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
# 1 CHEMICAL
BENZCOACRIDINE
BENZYL ALCOHOL
BENZYL CHLORIDE
CAR80FURAN
CHLORNAPHAZINE
CHLOROACETALDEHYDE
CHLOROACETIC ACID
CYCLOHEXANE
CYCLOHEXANONE
DAUNOHYCIN
DIALLATE
DIBENZO(A,E)PYRENE
DIBENZO(A,H)PYRENE
DICAMBA
DICHLOROPROPENE.CIS-1,3-
01CHLORVOS
DIETHYL S-HETHYL DITHIOPHOS
OIMETHOATE
DIMETHYCARBAMOYL CHLORIDE
OIPHOSPHORAMIDE, OCTAMETHYL
DITHIOBIURET
DIURON
ENDOSULFAN SULFATE
ETHYL METHACRYLATE
ETHYLENETHIOUREA
FAMPHUR
FLUORINE
FREON 113
HAXAETHYL TETRAPHOSPHATE
NEXACHLORONAPHITHALENE
HYOROQUINONE
ISOFLUORPHATE
M-CRESOL
MALE 1C HYDRAZIDE
MANGANESE
MEVIMPHOS
MITOMYCIN C
MUSIMOL
N-AHINOTHIOXOMETHYL ACETAMIDE
N-NITROSO-N-ETHYLUREA
N-NITROSOMETHYLVINYLAMINE
NITRIC OXIDE
NITROGEN DIOXIDE
NITROGLYCERINE
PARALDEHYDE
PERCHLOROMETHYLMERCAPTAN
POTASSIUM CYANIDE
POTASSIUM SILVER CYANIDE
SODIUM CYANIDE (NA(CN))
SODIUM FLUOROACETATE
SODIUM HYDROXIDE
STRYCHNINE
TEPP
TETRANITROMETHANE
THALLIC OXIDE
THALLOUS CHLORIDE
THALLOUS SULFATE
THIOACETAMIDE
THIOUREA
TOLUENE DIISOCYANATE
TRANS-1 ,3-DICHLOROPROPENE
TRIFLURALIN
CASNUM
00225-51-4
00100-51-6
00100-44-7
01563-66-2
00494-03-1
00107-20-0
00079-11-8
00110-82-7
00108-94-1
20830-81-3
02303-16-4
00192-65-4
00189-64-0
01918-00-9
10061-01-5
00062-73-7
03288-58-2
00060-51-5
00079-44-7
00152-16-9
00541-53-7
00330-54-1
01031-07-8
00097-63-2
00096-45-7
00052-85-7
07782-41-4
00076-13-1
00757-58-4
01335-87-1
00123-31-9
00055-91-4
00108-39-4
00123-33-1
07439-96-5
07786-34-7
00050-07-7
02763-96-4
00591-08-2
00759-73-9
04549-40-0
10102-43-9
10102-44-0
00055-63-0
00123-63-7
00594-42-3
00151-50-8
00506-61-6
00143-33-9
00062-74-8
01310-73-2
00057-24-9
00107-49-3
00509-14-8
01314-32-5
07791-12-0
07446-18-6
00062-55-5
00062-56-6
26471-62-5
10061-02-6
01582-09-8
SOURCE
HSL,RR1,RUL
GUL.SF.SAR
AC,HSL,RR1
AC,HSL,OPP
HSL,OWS,RR1
AC,HSL,RR1
AC.NJ.OTS
HSL,NJ,OTS
HSL.OTS.SAR
HSL,OUS,RR1
HSL,NJ,RR1
GUL,RR1,RUL
GUL.RR1.RUL
HSL.OPP.SF
GUL.SF.SAR
AC.HSL.OPP
HSL.OWS.RR1
AC,HSL,RR1
HSL.NJ.RR1
AC.HSL.RR1
AC.HSL.RR1
HSL.OPP.SF
HSL.OPP.SF
GUL.OUS.RR1
HSL.NJ.RR1
GUL.HSL.RR1
AC.HSL.RR1
NJ.OTS.SAR
HSL,OWS,RR1
AC.NJ.OTS
AC.NJ.OTS
AC.HSL.RR1
H20.HSL.NJ
HSL.OUS.RR1
GUL.NJ.SAR
AC.HSL.OPP
AC
AC.HSL.RR1
HSL
HSL.NJ.RR1
HSL.NJ.RR1
AC, HSL.RR1
AC.HSL.RR1
HSL.NJ.RR1
HSL.OWS.RR1
AC.HSL.OWS
AC.HSL.RR1
AC.HSL.RR1
AC.HSL.RR1
AC.HSL.RR1
AIR, HSL, NJ
AC.HSL.RR1
AC.HSL.RR1
AC,HSL,RR1
AC.HSL.RR1
AC.HSL.RR1
AC.HSL.RR1
HSL.NJ.RR1
HSL.NJ.RR1
HSL.OTS.SAR
GUL.SF.SAR
NJ.OPP.SF
*
P1
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
P2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
B-6
-------
Appendix B (continued)
REC #
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
/ CHEMICAL
VANADIUM PENTOXIDE
ZINC PHOSPHIDE
1,2-BUTYLENE OXIDE
1,3-OICHLOROPROPANE
1.4-DICHLORO-2-BUTENE
2,4-DIAMINO AN I SOL SULFATE
2,4-DIAMINOANISOL
2,4-DIBROMOANILINE
2-CHLOROTOLUENE
2-ETHOXY ETHANOL
2.3-EPOXYBUTANE
4,4>-ISOPROPYLIDENIPHENOL
4,4'-METHYLENE DIANILINE
5-NITRO-O-TOLUIDINE
ACETIC ACID, THALLIUM(I) SALT
ACETIC ACID, LEAD SALT
ACETYL CHLORIDE
ALUMINUM
AMETRYN
AMITROLE
AMMONIUM VANADATE
ANTIMONY TRIOXIDE
ARSENIC ACID
ATRATON
AZASERINE
BARBAN
BARIUM CYANIDE
BENZENE, 1,4-DINITRO-
BENZENEARSONIC ACID
BIPHENYL
BROMINE
BROMOCHLOROMETHANE
BRUCINE
C.I DISPERSE YELLOW 3
CADMIUM CHLORIDE
CADMIUM OXIDE
CALCIUM CHROMATE
CALCIUM CYANIDE
CARBAMIC ACID, METHYLNITROSO-
CHLORAMBEN
CHLORAMBUCIL
CHLORDANE, ALPHA
CHLORDANE, GAMMA
CHLOROTHALONIL
CHLORPROPHAM
CREOSOTE
CYANOGEN CHLORIDE
CYCLOPHOSPHAMIDE
DALAPON
DIAMINOTOLUENE(MIXED ISOMERS)
DIAZINON
DIETHYL-P-NITROPHENYLPHOSPHATE
DIETHYLSTILBESTROL
DIGLYCIDYL ETHER
DIOXOLANE
DIRECT BLACK 38
DIRECT BLUE 6
DIRECT BROWN 95
ENDOTHALL
ETHOPROPHOS
ETHYL METHANESULFONATE
ETHYLENEBIS(DITHIOCARBAMICACID
CASNUM
01314-62-1
01314-84-7
00106-88-7
00142-28-9
00764-41-0
39156-41-7
00615-05-4
00615-57-6
00095-49-8
00110-80-5
00099-30-9
00080-05-7
00101-77-9
00099-55-8
00563-66-8
00301-04-2
00075-36-5
07429-90-5
00834-12-8
00061-82-5
07803-55-6
01309-64-4
07778-39-4
01610-17-9
00115-02-6
00101-27-9
00542-62-1
00100-25-4
00098-05-5
00092-52-4
07726-95-6
00074-97-5
00357-57-3
02832-40-8
10108-64-2
01306-19-0
13765-19-0
00592-01-8
00615-53-2
00133-90-4
00305-03-3
05103-71-9
05103-74-2
01897-45-6
00101-21-3
08001-58-9
00506-77-4
00050-18-0
00075-99-0
25376-45-8
00313-41-5
00311-45-5
00056-53-1
02238-07-5
00646-06-0
01937-37-7
02602-46-2
16071-86-6
00145-73-3
13194-48-4
00062-50-0
00111-54-6
SOURCE
AC,HSL,RR1
AC,HSL,RR1
NJ,OTS
HSL.OPP
HSL.OTS
NJ.OTS
NJ,OTS
OTS
OPP.OTS
NJ.OTS
OTS.SF
NJ.OTS
NJ.OTS
HSL.RR1
HSL.RR1
HSL.RR1
HSL.RR1
GWL.NJ
OPP.SF
HSL.RR1
HSL.OWS
HSL.OTS
HSL.RR1
OPP.SF
HSL.RR1
OPP.SF
HSL.RR1
AC.GWL
AC.RR1
NJ.OTS
AC, AIR
OPP.SAR
HSL.RR1
NJ.OTS
HSL.OTS
AC, OTS
HSL.RR1
HSL.RR1
HSL.RR1.H20
NJ.OPP
HSL.RR1
OPP.SF
OPP.SF
NJ.OPP
OPP.SF
HSL.SAR
HSL.RRI
HSL.RR1
OPP.HSL
NJ.OTS
OPP.SF
HSL.RR1
HSL.RR1
AC, OTS
AC, OTS
NJ.OTS
NJ.OTS
NJ.OTS
HSL.RR1
AC.OPP
HSL.RR1
HSL.OWS
P1
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
*
P2
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
B-7
-------
Appendix B (continued)
REC #
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
/ CHEMICAL
FERRIC DEXTRAN
FLUORIDE
FLUORMETUROW
FLUOROACETIC ACID
FORMAMIDE.N.N-OIMETHYL-
FORMIC ACID
HEXAMETHYLPHORAM1DE
HEXANE
LASIOCARPINE
LEAD PHOSPHATE
LINURON
MERCURIC CHLORIDE
METHYL ACRYLATE
METHYL ETHYL KETONE PEROXIDE
METHYL METHANESULFONATE
METHYL TERT-BUTYL ETHER
METHYL-N'-NITRO-N-NITROSOGUAN
METHYLENEBISPHENYLISOCYANATE
METHYLTHIOURACIL
MISITYLENE
N-NITROSOMETHYLETHYLENEAMINE
NEBURON
NICKEL CYANIDE
N I TROSONORN 1 COT I NE , N -
OCTACHLORONAPHTHALENE
OXAMYL
OXYDISULFOTON
PERACETIC ACID
PHENYLENEDIAMINE.P-
PROMETON
PROMETRYM
PROPAZINE
PROPHAM
PROPOXUR
PROPYLENE
RESERP1NE
SILVER CYANIDE
SIMAZINE
SODIUM
STREPTOZOTOCIN
STRONTIUM SULFIDE
SULFUR DIOXIDE
SWEP
TERBUFOS
THALLIUM(I) NITRATE
TIN
TRICHLOROMETHANETHIOL
URACIL MUSTARD
ZINC CYANIDE
BENZOTR I CHLORIDE
SULFURIC ACID
AZINPHOS-METHYL
CAPTAN
CARBAMIC ACID, ETHYL ESTER
CARBAMIDE, N-METHYL-N-NITROSO
CHLORINE
DICHLOROETHYLENE(1,2)
DITHIAZANINE IODIDE
ETHION
HYDROGEN CHLORIDE
KELTHANE
HAL AT HI ON
CASNUM
09004-66-4
16984-48-8
02164-17-2
00144-49-0
00068-12-2
00064-18-6
00680-31-9
00110-54-3
00303-34-4
07446-27-7
00330-55-2
07487-94-7
00096-33-3
01338-23-4
00066-27-3
01634-04-4
00070-25-7
00101-68-8
00056-04-2
00108-67-8
10595-95-6
00555-37-3
00557-19-7
16543-55-8
02234-13-1
23135-22-0
02497-07-6
00079-21-0
00106-50-3
01610-18-0
07287-19-6
00139-40-2
00122-42-9
00114-26-1
00115-07-1
00050-55-5
00506-64-9
00122-34-9
07440-23-5
18883-66-4
01314-96-1
07446-09-5
01918-18-9
13071-79-9
10102-45-1
07440-31-5
00075-70-7
00066-75-1
00557-21-1
00098-07-7
07664-93-9
00086-50-0
00133-06-2
00051-79-6
00684-93-5
07782-50-5
00540-59-0
00514-73-8
00563-12-2
07647-01-0
00115-32-2
00121-75-5
SOURCE
HSL.RR1
GWL.SAR
NJ.OPP
AC,H20
OTS.SAR
HSL.RR1
NJ.OTS
OTS.SAR
HSL.RR1
HSL.RR1
OPP.SF
AC, AIR
NJ.OTS
HSL.RR1
GWL.RR1
NJ.OTS
HSL.RR1
NJ.OTS
HSL.RR1
AC.OPP
GUL.RR1
OPP.SF
HSL.RR1
NJ.RR1
NJ.OTS
AC.OPP
AC.OPP
AC.NJ
NJ.OTS
OPP.SF
OPP.SF
OPP.SF
OPP.SF
NJ, OPP.SF
AIR.NJ
HSL.RR1
HSL.RR1
OPP.SF
GUL.HSL
HSL.RR1
HSL.RR1
AC.SAR
OPP.SF
AC.OPP
HSL.RR1
GUL.SAR
GWL.RR1
HSL.RR1
HSL.RR1
AC.HSL.NJ.RR1
AC.HSL.NJ.SAR
AC.HSL.SF
HSL.NJ.SF
HSL.NJ.RR1
HSL.NJ.RR1
AC.HSL.NJ
NJ.SF.SAR
AC
AC.HSL.SF
AC.HSL.NJ
HSL.NJ.SF
HSL.SF.SAR
P1
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
• 2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
P2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3
3
2
2
2
2
2
2
2
2
2
2
2
B-8
-------
Appendix B (continued)
REC *
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
t 1 CHEMICAL
MEXACARBATE
NITRIC ACID
TOLUENE 2 , 6-0 1 1 SOCYANATE
TRICLOROPHON
1,3-DICHLOROPROPENE
1-BUTANOL
ARSENOUS TRICHLORIDE
BENZENESULFONYL CHLORIDE
BENZO(J)FLUORANTHENE
BENZOYL CHLORIDE
CALCIUM ARSENATE
CARBOPHENOTHION
CITRUS RED NO. 2
COUMAPHOS
CROTONALDEHYDE, (E)-
CUMENE HYDROPEROXIDE
DIBENZ(A,H)ACRIDINE
DIBENZ(A,J)ACRIDINE
D18ENZO(C,G)CARBAZOLE(7H)
DICHLOR08ENZENE, MIXED
DIOXATHION
ETHYL ACRYLATE
ETHYLENE GLYCOL
ETHYLENEDIAMINE
FURAN
MI REX
NITROPHENOL, MIXED
PARIS GREEN
PCBS
PHOSPHORIC ACID
PHOSPHOROUS OXYCHLORIDE
PHOSPHORUS TRICHLORIDE
POTASSIUM ARSENITE
PROPIOLACTONE.BETA
PYRIDINE, 4-AMINO-
OU INCLINE
SODIUM ARSENATE
SODIUM ARSENITE
SODIUM AZIDE (NA(N3))
SODIUM SELENITE
TETRAHYDROFURAN
THALLOUS CARBONATE
TITANIUM TETRACHLORIDE
TOLU1DINE.O-
(ETHOXYMETHYDBUTANEDIOIC ACID
OPENTACHLOROAN I L I NE ( 2 . 3 , 4 , 5 , 6-
1-EPOXY-4.4.4-TRICHLOROBUTANE
2,4,5-TP ACID (SILVEX)
2,4,6-TRINITROTOLUENE
2-(2-BUTOXYETHOXY)ETHYLACETATE
3,3-TRICHLORO-1,2-EPOXYPROPANE
3.5-DICHLOROBENZOIC ACID
3-(2-XENYLOXY)1 ,2-EPOXYPROPANE
4-AMINOAZOBENZENE
ACEFLUOREFEN
ACENAPHTHENE
ACETAMIDE
ACETIC ACID
ACETIC ACID, ETHYL ESTER
ACETIC ANHYDRIDE
ACETONE THIOSEMICARBAZIDE
ACETYL BROMIDE
CASNUM
00315-18-4
07697-37-2
00091-08-7
00052-68-6
00542-75-6
00071-36-3
07784-34-1
00098-09-9
00205-82-3
00098-88-4
07778-44-1
00786-19-6
06358-53-8
00056-72-4
00123-73-9
00080-15-9
00226-36-8
00224-42-0
00194-59-2
25321-22-6
00078-34-2
00140-88-5
00107-21-1
00107-15-3
00110-00-9
02385-85-5
25154-55-6
12002-03-8
01336-36-3
07664-38-2
10025-87-3
07719-12-2
10124-50-2
00057-57-8
00504-24-5
00091-22-5
07631-89-2
07784-46-5
26628-22-8
10102-18-8
00109-99-9
06533-73-9
07550-45-0
00095-53-4
00529-64-0
00527-20-8
03083-25-8
00093-72-1
00118-96-7
00124-17-4
03083-23-6
00051-36-5
07144-65-2
00060-09-3
50594-66-6
00083-32-9
00060-35-5
00064-19-7
00141-78-6
00108-24-7
01752-30-3
00506-96-7
SOURCE
AC.HSL.SF
AC,HSL,NJ
AC, HSL.NJ
AC, HSL.NJ
HSL.NJ
HSL.NJ
AC.HSL
AC.HSL
RRI,RUL
HSL.NJ
AC.HSL
AC.SF
RR1.RWL
AC.HSL
AC.HSL
NJ.HSL
RR1.RWL
RR1.RUL
RR1.RWL
HSL.NJ
AC.SF
HSL.NJ
NJ.SAR
AC.HSL
AC.HSL
SF.SAR
HSL.SAR
AC.HSL
NJ.SAR
HSL.NJ
AC.HSL
AC.HSL
AC, HSL
AC.NJ
AC.HSL
HSL.NJ
AC.HSL
AC.HSL
AC.HSL
AC.HSL
HSL.SAR
AC.HSL
AC.NJ
NJ.RR1
OTS
OTS
OTS
SAR
SAR
OTS
OTS
OPP
OTS
NJ
OPP
SAR
NJ
HSL
HSL
HSL
AC
HSL
P1 P
1 I
1 I
1 2
1 2
1 1
1 1
1 1
1 1
1 1
1 1
1
1
1
1
1
1
1 1
1 1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
2
3
3
3
3
3
D
3
3
3
3
3
3
3
3
3
9
9
3
B-9
-------
Appendix 8 (continued)
REC #
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
/ CHEMICAL
ACRYLYL CHLORIDE
ADIPIC ACID
AOIPONITRILE
AFLATOX1N 81
ALACHLOR
ALDICARB SULFONE
ALDICAR8 SULFOXIDE
ALKYL TINS
ALKYL TINS
ALKYL TINS
ALKYL TINS
ALKYL TINS
ALKYL TINS
ALKYL TINS
ALLYLAMINE
ALPHA-METHYLSTYRENE
ALUMINUM OXIDE
ALUMINUM SULFATE
AMINO-2-METHYLANTHRAQUlNONE,1-
AM1NOANTHRAQUINONE, 2-
AMINOCARB
AMINOPTERIN
AM1NOUNDECANOIC 11
AM I TON
AM I TON OXALATE
AMMONIUM ACETATE
AMMONIUM BENZOATE
AMMONIUM BICARBONATE
AMMONIUM BICHROMATE
AMMONIUM BI FLUORIDE
AMMONIUM BISULFITE
AMMONIUM CARBAMATE
AMMONIUM CARBONATE
AMMONIUM CHLORIDE
AMMONIUM CHROMATE
AMMONIUM CITRATE (DIBASIC)
AMMONIUM FLUOBORATE
AMMONIUM FLUORIDE
AMMONIUM HYDROXIDE
AMMONIUM NITRATE (SOLUTION)
AMMONIUM OXALATE
AMMONIUM OXALATE
AMMONIUM OXALATE
AMMONIUM PICRATE
AMMONIUM SILICOFLUORIDE
AMMONIUM SULFAMATE
AMMONIUM SULFATE (SOLUTION)
AMMONIUM SULFIDE
AMMONIUM SULFITE
AMMONIUM TARTRATE
AMMONIUM TARTRATE
AMMONIUM THIOCYANATE
AMMONIUM THIOSULFATE
AMMON IUMCHLOROPLAT I NATE
AMPHETAMINE
AMYL ACETATE
AMYL ISOACETATE
AMYL SECACETATE
AMYL TERTACETATE
ANILINE HYDROBROMIDE
ANILINE HYDROCHLORIDE
ANILINE, 2,4,6-TRIMETHYL
CASNUM
00814-68-6
00124-04-9
00111-69-3
01162-65-8
15972-60-8
01646-88-4
01646-87-3
00077-58-7
26636-01-1
25168-24-5
25168-21-2
25852-70-4
54849-38-6
01185-81-5
00107-11-9
00093-83-9
01344-28-1
10043-01-3
00082-28-0
00117-79-3
02032-59-9
00054-62-6
02432-99-7
00078-53-5
03734-97-2
00631-61-8
01863-63-4
01066-33-7
07789-09-5
01341-49-7
10192-30-0
01111-78-0
00506-87-6
12125-02-9
07788-98-9
03012-65-5
13826-83-0
12125-01-8
01336-21-6
06484-52-2
05972-73-6
14258-49-2
06009-70-7
00131-74-8
16919-19-0
07773-06-0
07783-20-2
12135-76-1
10196-04-0
14307-43-8
03164-29-2
01762-95-4
07783-18-8
16919-58-7
00300-62-9
00628-63-7
00123-92-2
00626-38-0
00625-16-1
00542-11-0
00142-04-1
00088-05-1
SOURCE
AC
HSL
AC
RR1
OPP
OPP
OPP
OTS
OTS
OTS
OTS
OTS
OTS
OTS
AC
OTS
NJ
HSL
NJ
NJ
SF
AC
OTS
AC
AC
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
NJ
HSL
HSL
HSL
HSL
HSL
HSL
NJ
HSL
HSL
HSL
HSL
HSL
HSL
AC
AC
HSL
HSL
HSL
HSL
OTS
OTS
AC
P1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
P2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
B-10
-------
Appendix B (continued)
REC # / CHEMICAL
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
ANISIDINE HYDROCHLORIDE, 0-
ANISIDINE, P-
ANSIDINE, 0-
ANTIMONY COMPOUNDS
ANTIMONY PENTACHLORIDE
ANTIMONY PENTAFLUORIDE
ANTIMONY POTASSIUM TARTRATE
ANTIMONY TR I BROMIDE
ANTIMONY TRICHLORIDE
ANTIMONY TRI FLUORIDE
ANT1MYCIN A
ANTRHAQUINONE
ARESNIC TRISULFIDE
ARSENIC ACID
ARSENIC 01SULFIDE
ARSINE
ATRAZINE, DEALKYLATED
AZINPHOS-ETHYL
AZIR1D1N1PROPAN01C ACID(1-),2-
BACITRACIN
BENTAZON
8ENZAMIDE
BENZENAMINE
BENZENAMINE, 3-URIFLUOROMETHY
BENZENE, 1-(CHLOROMETHYL)-4-NI
BENZENEOIAMINEd
BENZENEDIAMINEd
BENZENEDIAMINEd
BENZENEDIAMINEd
BENZENEDIAMINEd
BENZENEDIAMINEd
BENZENEDIAMINEd
BENZENEDIAMINEd
BENZENEDIAMINEd
BENZENEDIAMINE,
,2-),4-CHLOROS
,2-),4-NITROSU
.3-)
,3-).2,4-DIETH
,3-).4,6-DIETH
,3-),4-ETHOXYS
,3-),ARETHYL-A
,4-),2-NITROSU
,4-),ETHANEDIO
2-METHYLDIHYDR
BENZENEDIAMINE, 2-METHYLDIHYDRO
BENZENEDIAMINE, AR.AR-DIETHYL-A
BENZENEDIAMMINEd,2),5-CHLORO-
8ENZENEDIOLd,2)
BENZONITRILE
BENZYL CYANIDE
BERNOLATE
. 4-C1-HYDROXY
BERYLLIUM CHLORIDE
BERYLLIUM FLUORIDE
BERYLLIUM NITRATE
BERYLLIUM NITRATE
BICYCLO(2.2.1)HEPTANE-2-CARBON
BIS(2,3-EPOSYPROPOXY)-1,4-DIOX
BIS(2,3-EPOXYPROPOXY)-1,4-DIOX
B1S(2-CHLOROETHYLISOPROPYL)ETH
BIS(2-EHTYLHEXYL)TEREPHTHALATE
BIS(2-ETHYLHEXYL)ADIPATE
BIS<2-METHYL-2,3-EPOXYPROPANE)
BISCCHLOROMETHYDKETONE
BIS(P-TERT-BUTYLPHENYL)PHENYL
BISPHENOL A GLYCIDYL ETHER
BISPHENYL A DIGLYCIDYLETHER
B1TOSCANATE
BORON AND COMPOUNDS
BORON TIRFLUORIDE
BORON TRICHLORIDE
BORON TRIFLURIDE
WITH METHYL
CASNUM
00134-29-2
00104-94-9
00090-04-0
01345-04-6
07647-18-9
07783-70-2
28300-74-5
07789-61-9
10025-91-9
07783-56-4
01397-94-0
00084-65-1
01303-33-9
01327-52-2
01303-32-8
07784-42-1
03397-62-4
02642-71-9
57116-45-7
01405-87-4
25057-89-0
00055-21-0
00101-61-1
00098-16-8
00100-14-1
68459-98-3
68239-82-7
00108-45-2
02095-02-5
02095-01-4
67801-06-3
68966-84-7
68239-83-8
62654-17-5
00615-45-2
06369-59-1
68479-98-1
42389-30-0
06912-68-1
00100-47-0
00140-29-4
01929-77-7
07787-47-5
07787-49-7
07787-55-5
13597-99-4
15271-41-7
10043-09-1
07487-28-7
39363-32-9
06422-86-2
00103-23-1
03775-85-7
00534-07-6
00115-87-7
01675-54-3
25085-99-8
04044-65-9
07440-42-8
07637-07-2
10294-34-5
00353-42-4
SOURCE P1 P2
NJ 1
NJ 1
NJ 1
OTS 1
HSL 1
AC 1
HSL 1
HSL 1
HSL 1
HSL 1
AC 1
OTS 1
HSL 1
HSL 1
HSL
AC
OPP
AC
OTS
AC
OPP
NJ
NJ
AC
AC
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
RR1
HSL
AC
OPP
HSL
HSL
HSL
HSL
AC
OTS
OTS
SF
OTS
NJ
OTS
AC
OTS
OTS
OTS
AC
SAR
AC
AC
AC
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
8-11
-------
Appendix B (continued)
REC tt 1 CHEMICAL
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
BROMACIL
BROMADIOLONE
BROMCK 1 - ) , 2 - CHLOROETHANE
8ROMO-2,4-DICHLOROANILlNE(6-)
BROMO-3,5-DlCHLOROANILlNE<4-)
BROMO-4,6-DINITROANILINE<2-)
BRONO-4-NITROANILINE(2-)
BROMO-4-NITROANILINE<2->
BROHO-6-CHLORO-4-NITROANILINE
BROMOANIL1NE HYDROCHLORIDEC4-)
BROMOANILINE(3->
BROMOANILINE{4-)
BROMOANININE, 2-
BROMOBENZENE
BROMOBENZYLCYANIDE(4- )
BUTACHLOR
BUTANEDIOC ACID,(ETHOXYMETHYLE
8UTENALC2)
BUTENAU2)
BUTOXYETHANOL(2->
BUTYL 2-ETHYLHEXHL PHTHALATE
BUTYL ACRYLATE
BUTYL ALCOHOL, SEC-
BUTYL CLYCIDYL ETHER, N-
BUTYL GLYCOL BUTYL PHTHALATE
BUTYL ISOVALERATE
BUTYL VINYL ETHER
8UTYLAMINE
BUTYL AM I NE, TERT-
BUTYLATE
BUTYLBENZYL PHTHALATE
BUTYLPHENYL OIPHENYL PHOSPHATE
BUTYRALOEHYDE
BUTYRIC ACID
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
. 22375
. ACID BLUE 9, D I AMMONIUM
. ACID BLUE 9, DISOOIUM SAL
. ACID GREEN 3
. AZIOC DIAZOCOPONYL
. BASIC GREEK 1
. BASIC GREEN 4
. BASIC RED 1
. BASIC RED 9 MONO HCL
. BASIC RED 9 MONO HCL
. DIREC RED 3,7
. DIRECT BLACK 21
. DIRECT BLACKI 4
. DIRECT BLUE 1
. DIRECT BLUE 15
. DIRECT BLUE 151
. DIRECT BLUE 2
. DIRECT BLUE 22
. DIRECT BLUE 25
. DIRECT BLUE 26
. DIRECT BLUE 76
. DIRECT BLUE 8
. DIRECT BLUE 98
. DIRECT BROWN 1,5,4
. DIRECT BROUN 1A
. DIRECT BROWN 2
. DIRECT BROUN 3
. DIRECT BROWN 59
CASNUM
00314-40-9
28772-56-7
00107-04-0
00697-86-9
01940-29-0
01817-73-8
13296-94-1
10401-50-0
00099-29-6
00624-19-1
00591-19-5
00106-40-1
00615-36-1
00108-86-1
16532-79-9
23184-66-9
55130-39-7
00123-73-9
04170-30-0
00111-76-2
00085-69-8
00141-32-2
00078-92-2
02426-08-6
00085-70-1
00109-19-3
00111-34-5
00109-73-9
00075-64-9
01008-41-5
00085-68-7
56803-37-3
00123-72-8
00107-92-6
06507-81-9
02650-18-2
03844-45-9
04680-78-8
20282-70-6
00633-03-4
00569-64-2
00989-38-8
00479-73-2
00569-61-9
03530-19-6
06739-62-4
02429-83-6
02610-05-1
02429-74-5
06449-35-0
02429-73-4
02586-57-4
02150-54-1
07082-31-7
16143-79-6
02429-71-2
06656-03-7
06360-54-9
02586-58-5
02429-82-5
02429-81-4
03476-90-2
SOURCE
OPP
AC
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OPP
OWS
OPP
OTS
HSL
HSL
OTS
OTS
NJ
HJ
OTS
OTS
AC
AC
HSL
HSL
OPP
SAR
OTS
NJ
HSL
OTS
NJ
NJ
NJ
OTS
AC
NJ
NJ
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
P1 P2
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
B-12
-------
Appendix B (continued)
REC # / CHEMICAL
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
C.
. DIRECT BROWN 6
. DIRECT BROUN 74
. DIRECT GREEN 6
. DIRECT GREEN 7
. DIRECT GREEN 8
. DIRECT ORANGE 6
. DIRECT ORANGE 8, C8 CI
. DIRECT RED 1
. DIRECT RED 28
. DIRECT RED 39
. DIRECT RED 85
. DIRECT VIOLET 1
. DIRECT VIOLET 22
. DIRECT YELLOW 28
. DISPERSE BLUE 79
. FOOD RED 15
. FOOD RED 5
. SOLVENT ORANGE 7
. SOLVENT YELLOW 14
. SOLVENT YELLOW 3
.; VAT YELLOW 4
CADMIUM ACETATE
CADMIUM BROMIDE
CADMIUM STEARATE
CADMIUM SULFIDE
CALCIUM
CALCIUM
CALCIUM ARSENITE
CALCIUM CARBIDE
CALCIUM CYANAMIDE
CALCIUM DOOECYLBENZENE SULFONA
CALCIUM HYPOCHLORITE
CANTHARIDIN
CARBAMIC ACID, METHYL-0-<(2,4-
CARBOFURAN INTERMEDIATE
CAR80FURAN INTERMEDIATE
CARBOFURAN INTERMEDIATE
CARBOFURAN PHENOL
CARBOFURAN PHENOL 3KET
CARBOFURAN, 3-HYDROXY
CARBONYL SULFIDE
CAR80XIN
CARBOXIN SULFOXIDE
CAREBECHOL CHLORIDE
CARVONE
CATECHOL
CHLORACETOPHENONE, 2-
CHLORENDIC ACID
CHLORENDIC ANHYDRIDE
CHLORFENVINFOS
CHLORINATED BENZENES
CHLORINATED BENZENES
CHLORINATED BENZENES
CHLORINATED NAPHTHALENES
CHLORINATED NAPHTHALENES
CHLORINATED NAPHTHALENES
CHLORINATED NAPHTHALENES
CHLORINATED PARAFFINS
CHLORINATED PARAFFINS
CHLORINATED PARAFFINS
CHLORINE DIOXIDE
CHLORMEPHOS
CASNUM
02893-80-3
08014-91-3
04335-09-5
03626-28-6
05422-17-3
06637-88-3
02429-79-0
02429-84-7
00578-58-0
06358-29-8
03567-65-5
02586-60-9
06426-67-1
08005-72-9
99999-99-9
00081-88-9
03761-53-3
03118-97-6
00842-07-9
00097-56-3
00128-66-5
00543-90-8
07789-42-6
02223-93-0
01306-23-6
07440-70-2
61789-36-4
52740-16-6
00075-20-7
00156-62-7
26264-06-2
07778-54-3
00056-25-7
26419-73-8
68298-46-4
13414-54-5
13414-55-6
01563-38-8
17781-16-7
16655-82-6
00463-58-1
05234-68-4
01775-70-9
00051-83-2
02244-16-8
00120-80-9
00532-27-4
00115-28-6
00115-28-5
00407-90-6
00608-95-3
00634-90-2
00634-66-2
01321-64-8
01321-65-9
28699-88-9
01335-88-2
61788-76-9
38920-70-7
63449-39-8
10049-04-4
24934-91-6
SOURCE
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
NJ
NJ
NJ
NJ
NJ
NJ
HSL
HSL
AC
OTS
GWL
OTS
HSL
HSL
NJ
HSL
HSL
AC
AC
OTS
OTS
OTS
OPP
OPP
OPP
NJ
OPP
OPP
AC
AC
NJ
NJ
OTS
OTS
AC
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
NJ
AC
P1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
*
P2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
B-13
-------
Appendix B (continued)
REC )t
803
804
805
806
807
808
809
810
811
812
813
8U
815
816
817
818
819
620
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
t / CHEMICAL
CHLORHEQUAT CHLORIDE
CHLORNEB
CHLORO-0-TOLUIDINE HYDROCHLORI
CHLORO-2,6-OINITROANILINE(3-)
CHLORO-2-NITROANILINE (4-)
CHLORO-3-NITROANILINE(4-)
CHLORO-4-NITROANILlNE(2->
CHLORO-4-NITROANILINE(2-)
CHLORO-4-NITROANILINE(3->
CHLORO-5-NITROANILINE(3->
CHLOROANILINE (2-)
CHLOROANILINE HYOROCHLOLRIDEC3
CHLOROANILINE HYDROCHLORIDE(2-
CHLOROANILINE HYDROCHLORIDE<2-
CHLOROANILINE HYDROCHLORIDE<4-
CHLOROANILINE(3-)
CHLOROBEHZOTR I CHIOS I DE
CHLOROBENZOTRICHLORIDEDC4-)
CHLOROBENZOTR1 FLUOR IDE, 4-
CHLOROOIBENZOOIOXINS
CHLOROOIBENZOFURANS
CHLOROOIFLUOROMETHANE
CHLOROETHANOL
CHLOROETHYL CHLOROFORMATE
CHLOROL-4,6-DIMITOANlLJNE<2-)
CHLOROHETHYLPROPENE
CHLOROPHACINONE
CHLOROSULFONIC ACID
CHLOROTOLUENE(4-)
CHLOROXURON
CHLORPYRIFOS
CHLORTHIOPHOS
CHORMIC ACID
CHROMIC ACETATE
CHROMIC ACID
CHROMIC CHLORIDE
CHROMIC SULFATE
CHROMOUS CHLORIDE
CIS-1,2-DICHLOROETHYLENE
C t S- HEPTACHLOROSTYRENE
CIS-PERMETHRIN
COBALT
COBALT CARBONYL
COBALT.((2,2*-ETHANED1YLBIS(NI
COBALTOUS BROMIDE
COBALTOUS FORMATE
COBALTOUS SULFAMATE
COLCHICINE
COPPER CYANIDE
COPPER CYANIDE
COPPER, BISCDIMEHTYLCARBAMCOITH
COUMAFURYL
COUMATETRALYL
CRESIDINE, P-
CRESYL DIPHENYL PHOSPHATE
CRESYLDIPHENYL PHOSPHATE
CRIMIDINE
CUPFERRON
CUPRIC ACETATE
CUPR1C CHLORIDE
CUPRIC NITRATE
CUPRIC OXALATE
CASNUM
00999-81-5
02675-77-6
03156-93-3
10250-71-2
00089-63-4
00635-22-3
00121-87-9
00769-11-9
00825-41-2
05344-44-5
00095-51-2
00141-85-5
00137-04-2
00563-04-2
20265-96-7
00108-42-9
02136-89-2
05216-25-1
00098-56-6
0000000000
0000000000
00075-45-6
00107-07-3
00627-11-2
03531-19-9
00563-47-5
03691-35-8
07790-94-5
00106-43-4
01982-47-4
02921-88-2
21923-23-9
07738-94-5
01066-30-4
11115-74-5
10025-73-7
10101-53-8
10049-05-5
00156-59-2
29086-39-3
54774-45-7
61789-14-5
10210-68-1
62207-76-5
07789-43-7
00544-18-3
14017-41-5
00064-86-8
00544-92-3
14763-77-0
00137-29-1
00117-52-2
05836-29-3
00102-71-8
26444-49-5
00078-31-9
00535-89-7
00135-20-6
00142-71-2
07447-39-4
03251-23-8
05893-66-3
SOURCE P
AC 1
OPP 1
HSL 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OUS 1
OSU 1
OTS 1
SAR
SAR
SAR
AC
AC
OTS
OTS
AC
HSL
OPP
AC
HSL
AC
HSL
HSL
HSL
AC
HSL
HSL
SAR
OTS
OPP
OTS
AC
AC
HSL
HSL
HSL
AC
HSL
RR1
OTS
AC
AC
NJ
OTS
OTS
AC
NJ
HSL
HSL
HSL
HSL
* *
1 P2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1 0
B-14
-------
Appendix B (continued)
REC i
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
t 1 CHEMICAL
CUPRIC SULFATE
CUPRIC SULFATE, AMHONIATED
CUPRIC TARTRATE
CYANAZINE
CYANOGEN
CYANOGEN
CYANOGEN IODIDE
CYANOPHOS
CYANUR1C FLUORIDE
CYCASIN
CYCLOATE
CYCLOHEXANEDIONE 1,3-,5-(2-(ET
CYCLOHEXANONE
CYCLOHEXIMIDE
CYCLOHEXLAHINE
CYCLOPENTANE
D ESTERS, 2,4-
O&C RED NO. 9
D-CRESYL GLYCIDYL ETHER
DB(2,4-)
DBENZENAMINE, 4-CHLORO-2-METHY
DCPA
OECABORANE
DEECBROMOD1PHENYL OXIDE
DEMENTON-8
DEMETON
DEMETON-0
OEMETON-S-METHYL
DKHEPTYL.NONYL.UNDECYDPHTHAL
DKHEXYL, OCTYL, DECYDPHTHALA
OI-ALPHA-DPICHLOLROHYDRIN
OI-TERT-BUTYL-PHENOL, 2,6-
DIALIFOS
OIAMtNO-1-METHYLBENZENE(1,2-)
DIAMINO-1-METHYLBENZENE(2,6-)
DIAMINO-2-METHYLPHENOL(4,6-)
DIAMINO-4-HETHYLBENZENE
OIAMINO-0-CRESOL(4,6)
DIAMINOANISOLE(P-)
DIAflINOAZOIBENZENE(2,4-} AND
DIAMINOBENZENE
DIAMINODIPHENYL ETHER, 4,4'
DIAMINOPHENOL DIHYOOROCHLORIDE
OIAMINOTOLUENE(2,5) SULFATE
DIAHINOTOLUENE(3,5-)
DIAZ I MONO
DIAZOMETHANE
DIBORANE
D I BROMO-4- ( 1 , 2-D I BROMOETHYL )CY
DIBROMO-4-NITROANILINE(2,6-)
D I BUTYL PHENYL PHOSPHATE
DICAMBA, 5-HYDROXY
D1CHLOBEN1L
DICHLOFENTHION
DICHLONE
DICHLORO-2,3-EPOXYBUTANE(1,4->
D1CHLORO-2-BUTENE
DICHLOROANILINE (2,4-)
DICHLOROANILIHE (2,5-)
DICHLOROANILINE(2,4-)
DICHLOROAHILINE3,5-)
DICHLOROBENZALKONIUM CHLORIDE
CASNUM
07758-98-7
10380-29-7
00815-82-7
21725-46-2
00460-19-5
02074-87-5
00506-78-5
02636-26-2
00675-14-9
14901-08-7
01134-23-2
99422-01-2
00108-04-1
00066-81-9
00108-91-8
00287-92-3
00094-11-1
05160-02-1
02425-79-8
00094-82-6
00095-69-2
01861-32-1
17702-41-9
01163-19-5
00126-75-0
08065-48-3
00298-03-3
00919-86-8
39393-37-8
27554-26-3
13403-37-7
00128-39-2
10311-84-9
02687-25-4
00823-40-5
00496-72-0
15872-73-8
05307-02-8
00532-82-1
00095-54-5
00101-80-4
00137-09-7
00615-50-9
00108-71-4
05333-41-5
00334-88-3
19287-45-7
03322-93-8
00827-94-1
02528-36-1
07600-50-2
01914-65-6
00097-17-6
00117-80-6
03583-47-9
01476-11-5
00095-76-1
00095-82-9
00554-00-7
00626-43-7
08023-53-8
SOURCE F
HSL 1
HSL \
HSL 1
OPP
HSL
RR1
AC
AC
AC
RR1
OPP
OTS
OTS
AC
AC
AC
HSL
OTS
OTS
OPP
OTS
OPP
AC
NJ
SF
AC
SF
AC
OTS
OTS
OTS
OTS
AC
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
NJ
OTS
OTS
OTS
HSL
NJ
AC
OTS
OTS
OTS
OPP
HSL
SF
HSL
OTS
OTS
OTS
OTS
OTS
OTS
AC
* *
1 P2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1 0
1 0
1 0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
8-15
-------
Appendix B (continued)
REC *
927
928
929
930
931
932
933
934
935
936
937
938
939
940
941
942
943
944
945
946
947
948
949
950
951
952
953
954
955
956
957
958
959
960
961
962
963
964
965
966
967
968
969
970
971
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
I / CHEMICAL
OICHLOR08EN2ENE(1,4-)
DICHLOROBENZOTRIFULORIDE, 3,4-
D I CHLOROMETHYLPHEN YLS I LANE
D1CHLOROPORPANE-OICHLOROPROPEN
DICHLOROPROP
DICHLOROPROPANE
DICHLOROPROPANE, 1,1-
DICHLOROPROPANOL (1,3-)
DICHLOROPROPANOL(2,3-)
DICHLOROPROPENE (1,1-)
OICHLOROPROPENE (1,3)
DICHLOROPROPENE 2,3-
DICHLORV05
DICROTOPHOS
DICYANAMIDI-DIETHYLENETRIAMINE
DIEPOXYBUTENE(1,2,3,4)
DIETHANOLAMINE
OIETHYL CHLOROPHOSPHATE
D I ETHYL SULFATE
DIETHYL-P-PHENYLENEOIAMINE
OIETHYLAMINE
DIETHYLCAR8AMKAZINE CITRATE
DIETHYLENE GLYCOL
DIETHYLENE GLYCOL ETHER (DGBE)
OIETHYLENETRIAMINE
01ETHYLHYDRAZINE(N,N)
OIETHYULHYDRA2INE, 1,2-
DIGITOXIN
DIGOXIN
OIISOOECYL PHENYL PHOSPHITE
OUSOOECYL PHTHALATE
DI ISOOECYLPHENYLPHOSPHATE
DIISOHEXYL PHTALATE
OIISONONYL PHTHALATE
OIISOPROPYL 8 1 PHENYL
DIISOPROPYL SULFATE
DIISOPROPYLPHENYLGLYCIDIC ACIO
01 ISOPROPYLPHENYLPHOSPHATE
DIME FOX
OIMEHTYL METHYLPHOSPHONATE
DIMETHOXYETHYL PHTALATE
DIMETHYL ADIPATE
DIMETHYL GLUTARATE
DIMETHYL HYDROGEN PHOSPHATE
DIMETHYL PHOSPHOROCHLOROOOTHIO
DIMETHYL SUCCINATE
DIMETHYL SULFIDE
OIMETHYL-P-PHEUYLENEDIAMINE
DIMETHYLAMINE
DIMETHYLAMINE
DIMETHYLANILINE, N,N-
DIMETHYLDCHLOROSILANE
01 MET I LAN
DINITRO(4,6)-0-CRESOL AND SALT
DINITRO-4-CHLOROANILINE(2,6-)
DINITROANILINE (2,4-)
DINITROANILINE(2,6-)
DINITROANILINE(3,5-)
D I NITROBENZENE, 0-
D I NITROBENZENE, MIXED
DINITROPHENOL
DINITROPHENOL, 2,5-
CASNUM
00110-46-7
00328-84-7
00149-74-6
08003-19-8
00120-36-5
26638-19-7
00078-99-9
00096-23-1
00616-23-9
00090-99-9
00542-75-6
26952-23-8
00622-73-7
00141-66-2
67753-54-2
00564-00-1
00111-42-2
00814-49-3
00064-67-5
00093-05-5
00109-89-7
01642-54-2
04206-61-5
00110-34-5
00111-40-0
00616-40-0
01615-80-1
00071-63-6
20830-75-5
25550-98-5
26761-40-0
51363-64-5
00146-50-9
28553-12-0
69009-90-1
02973-10-6
01334-99-2
51496-03-8
00115-26-4
00756-79-6
00117-82-8
00627-93-0
01119-40-0
00868-85-9
02524-03-0
00106-65-0
0075-18-3
00099-98-9
00109-89-7
00124-40-3
00121-69-7
00075-78-5
00644-64-4
00534-52-1
05388-62-5
00097-02-9
00606-22-4
00618-87-1
00528-29-0
25154-54-5
25550-58-7
00329-71-5
SOURCE P
HSL 1
OTS 1
AC 1
HSL 1
OPP 1
HSL 1
HSL 1
OUS 1
OSU 1
OPP 1
RR1 1
HSL 1
NJ 1
AC 1
OTS 1
H20 1
NJ 1
AC
NJ
AC
HSL
AC
OTS
OTS
OTS
RR1
HSL
AC
AC
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
AC
OTS
OTS
OTS
OTS
OTS
AC
OTS
AC
AC
AIR
HSL
NJ
AC
AC
RR1
OTS
OTS
OTS
OTS
HSL
HSL
HSL
HSL
* *
1 P2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
B-16
-------
Appendix B (continued)
REC #
989
990
991
992
993
994
995
996
997
998
999
1000
1001
1002
1003
1004
1005
1006
1007
1008
1009
1010
1011
1012
1013
1014
1015
1016
1017
1018
1019
1020
1021
1022
1023
1024
1025
1026
1027
1028
1029
1030
1031
1032
1033
1034
1035
1036
1037
1038
1039
1040
1041
1042
1043
1044
1045
1046
1047
1048
1049
1050
/ CHEMICAL
DINITROPHENOL, 2,6-
OINITROTOLUENE
DINITROTOLUENE, 3,4-
DINOTERB
DIPHACINONE
DIPHENAMID
DIPHENYLAMINE
DIPHENYLHYDRAZINE
DIPROPYLAMINE
DIQUAT
DIQUAT
DISULFOTON SULFONE
DIUNDECYL PHTHALATE
DOOECYHLBENZENESULFONIC ACID
OOMOTRPBEMZEME. M-
DVINTLCYCLOHEXENE (4->
EDTA
EMETINE, DIHYDROCHLORIDE
ENOOTHION
ENDRIN KETONE
EPIC
EPINEPHRINE
EPN
EPOXY-1-PROPANOL STEARATE, 2,3
EPOXY-2-ETHYLHEXANOL. 2,3-
EPOXY-3-ALLYOXYPROPANE ,1,2-
EPOXY-3-BROMOPROPANE(1,2-)
EPOXY-3-PROPOXYPROPANE, 1,2-
EPOXYBUTYRIC ACID, BUTYL ESTER,
EPOXYOECANE
EPOXYDOOECANE(1,2-)
EPOXYHEPTADECANE
EPOXYHEXADECANE(1,2->
EPOXYNONADECANEd ,2-)
EPOXYOCTADECANEd ,2- )
EPOXYPENTADECANE(1,2-)
EPOXYPROPANAL OLEATE, 2,3-
EPOXYTETRADECANE(1,2->
ERGOCALCIFEROL
ERGOTAMINE TARTRATE
ETHANEXULFONYL CHLORIDE, 2-CHL
ETHANOL, 1,2-DICHLORO-, ACETA
ETHANOL-2-0(2,4-DlAMINOPHENOXY
ETHOXY-H-PHENYLENEDIAMINE SULF
ETHOXYMETHYL BUTANEDIOC ACID
ETHYL CHLOROFORMATE
ETHYL ETHER
ETHYL GLYCIDATE
ETHYL GLYCIDYL ETHER
ETHYL THOCYAMATE
ETHYLBIS(2-CHLOROETHYL)AMINE
ETHYLENE
ETHYLENE BIS(OXYETHYLENE) DIAC
ETHYLENE FLUOROHYDRIN
ETHYLENEDIAMINETETRA(METHYLENE
ETHYLENEOIAMINETETRA(METHYLENE
ETHYLENEOIAMINETETRACPHOSPHONI
ETHYLHEXANOIC ACID
ETHYLHEXANOL, 2-
ETHYLHEXYL DIPHENYL PHOSPHATE
ETHYLMERCURIC PHOSPHATE
ETHYLTOLUENE (MIXED ISOMERS)
CASNUM
00573-56-8
25321-14-6
00610-39-9
01420-07-1
00082-66-6
00957-51-7
00122-39-4
00530-50-7
00142-84-7
00085-00-7
02764-72-9
02497-06-5
03648-20-2
27176-87-0
00099-65-0
00100-40-3
00060-00-4
00316-42-7
02778-04-3
53494-70-5
00759-94-4
00051-43-4
02104-64-5
07460-84-6
00078-72-8
00106-92-3
03132-64-7
03126-95-2
10140-87-1
02404-44-6
02855-19-8
22092-38-2
07320-37-8
67860-04-2
07390-81-0
18833-25-5
05431-33-4
03234-28-4
00050-14-6
00379-79-3
01622-32-8
10140-87-1
66422-95-5
68015-98-5
5-130-49-9
00541-41-3
00060-29-7
04660-80-4
04016-11-9
00542-90-5
00538-07-8
00074-85-1
00011-21-7
00371-62-0
01429-50-1
68188-96-5
15142-96-8
00149-57-5
00104-76-7
01241-94-7
02335-25-8
25550-14-5
SOURCE P
HSL
HSL
HSL
AC
AC
OPP
GUL
HSL
HSL
HSL
HSL
OPP
OTS 1
HSL 1
HSL 1
OTS 1
HSL
AC
AC
SF
OPP
HSL
AC
OTS
OTS
OTS
OTS
OTS
AC
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS
OTS
OTS
AC
AC
AC
AC
OTS
OTS
OTS
NJ
HSL
OTS
OTS
AC
AC
NJ
OTS
AC
OTS
OTS
OTS
OTS
OTS
OTS
AC
OTS
* *
1 P2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8-17
-------
Appendix B (continued)
REC tt
1051
1052
1053
1054
1055
1056
1057
1058
1059
1060
1061
1062
1063
1064
1065
1066
1067
1068
1069
1070
1071
1072
1073
1074
1075
1076
1077
1078
1079
1080
1081
1082
1083
1084
1085
1086
1087
1088
1089
1090
1091
1092
1093
1094
1095
1096
1097
1098
1099
1100
1101
1102
1103
1104
1105
1106
1107
1108
1109
1110
1111
1112
/ CHEMICAL
ETRIDIAZOLE
FENAMINPHOS
FENARIMOL
FENITROTHION
FENSULFOTHION
FENURON
FENURON TCA
FERRIC AMMONIUM CITRATE
FERRIC AMMONIUM OXALATE
FERRIC AMMONIUM OXALATE
FERRIC CHLORIDE
FERRIC FLUORIDE
FERRIC NITRATE
FERRIC SULFATE
FERROCENE, ACETYL
FERROUS AMMONIUM SULFATE
FERROUS CHLORIDE
FERROUS SULFATE
FLUENETIL
FLUOROACETYL CHLORIDE
FLUOROALKENES
FLUOROALKENES
FLUOROALKENES
FLUOROALKENES
FLUOROALKENES
FLUOROALKENES
FLUOROALKENES
FLUOROALKENES
FLUOROURACIL
FLURIDONE
FONOFOS
FORMALDEHYDE CYANOHYDRIN
FORMAMIDE
FORMETANATE
FORMOTHION
FORMPARANATE
FOSTHIETAN
FUBERIDAZOLE
FUMARIC ACID
FURFURAL
GALLIUM TRICHLORIDE
GLYCIDIC ACID, 3-METHYL-3-PHEN
GLYCIDOL
GLYCIDYHLDOOECANOIC ACID
GLYCIDYL ACETATE
GLYCIDYL ACRYLATE
GLYCIDYL LAURATE
GLYCIDYL METHACRYLATE
GLYCOL ETHERS
HEAVY CATALYTIC CRACKED NAPHTH
HEAVY NAPHTHENIC DISTILLATE
HEPTACHLOROSTYRENE
HEPTANE
HEXACHLOROCYCLOHEXANE ISOMERS
HEXACHLOROCYCLOPENTANTENE
HEXACHLORONOBORNAD I ENE
HEXAFLUOROI SOBUTYLENE
HEXAFLUOROPROPYLENE OXIDE
HEXAMETHYLENEDIAMINE, N.N-DIBU
HEXANE
HEXAZINONE
HYDRAZINE SULFATE
CASNUM
02593-15-9
22224-92-6
60168-88-9
00122-14-5
00115-90-2
00101-42-8
04482-55-7
01185-57-5
02944-67-4
55488-87-4
07705-08-0
07783-50-8
10421-48-4
10028-22-5
01271-55-2
10045-89-3
07758-94-3
07782-63-0
04301-50-2
00359-06-8
00075-02-5
00116-14-3
00818-92-8
01691-13-0
, 01184-60-7
01630-78-0
00359-11-5
01630-77-9
00051-21-8
59756-60-4
00944-22-9
00107-16-4
00075-12-7
23422-53-9
02540-82-1
17702-57-7
21548-32-3
03878-19-1
00110-17-8
00098-01-1
13450-90-3
00077-83-8
00556-52-5
63978-73-4
06387-89-9
00106-90-1
01984-77-6
00106-91-2
00111-15-9
64741-54-4
64742-52-5
61593-44-0
00142-82-5
00608-73-1
00074-47-4
03389-71-7
00382-10-5
00428-59-1
04835-11-4
28182-81-2
51235-04-2
10034-93-2
SOURCE P
OPP 1
AC 1
OPP
AC
AC
SF
SF
HSL
HSL
HSL
HSL
HSL
HSL
HSL
OTS
HSL
NJ
HSL 1
AC 1
AC 1
OTS 1
OTS
OTS
OTS
OTS
OTS
OTS
OTS
AC
OPP
AC 1
AC 1
OTS 1
AC \
AC 1
AC 1
AC
AC
HSL
HSL
AC
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
SAR
HSL
RR1
OTS
OTS
OTS
AC
OTS
OPP
NJ
1* P2*
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
B-18
-------
Appendix B (continued)
REC #
1113
1114
1115
1116
1117
1118
1119
1120
1121
1122
1123
1124
1125
1126
1127
1128
1129
1130
1131
1132
1133
1134
1135
1136
1137
1138
1139
1140
1141
1142
1143
1144
1145
1146
1147
1148
1149
1150
1151
1152
1153
1154
1155
1156
1157
1158
1159
1160
1161
1162
1163
1164
1165
1166
1167
1168
1169
1170
1171
1172
1173
1174
/ CHEMICAL
HYDROBROHIDE
HYDROOESULFURIZED
HYDROGEN PEROXIDE
HYDROGEN SELENIDE
KEROSINE
<>52X)
HYDROLDESULFURIZED MIDDLE DIST
HYOROXYLAMINE AND
HYDROXYLAMINE AND
HYDROXYLAMINE AND
HYDROXYLAMINE AND
ITS SALT
ITS SALT
ITS SALT
ITS SALT
HYDROXYLAMINE, 0-(3-CHLORO-2-PR
INDOMETHACIN
IRGACURE
IRGANOX 1920
IRIDIUM TETRACHLORIDE
IRON
IRON, PENTACARBONYL
ISOBENZAN
ISOBUTYL ACETATE
ISOBUTYRALDEHYDE
ISOBUTYRIC ACID
ISOBUTYRONITRILE
ISOCYANIC ACID, 3
ISODECYL DIPHENYL
ISOOCTYL ISODECYL
,4-DICHLOROPH
PHOSPHATE
PHTALATE
I SOPHORONE D 1 1 SOCYANATE
ISOPRENE
ISOPROPANOL BIPHENYL
I SOPROPANOLAM I NEDODECYLBENZENE
ISOPROPYL ALCOHOL
ISOPROPYL CHLOROFORMATE
ISOPROPYL FORMATE
ISOPROPYL GLYCIDYL ETHER
ISOPROPYLMETHYLPRAZOLYL DIMETH
ISOPROPYLPHENYLDIPHENYL PHOSPH
ISOPROPYLTOLUENE
KANEB
KEROSINE
LACTONITRILE
LAURYL GLYCIDYL ETHER
LEAD
LEAD ARSEDNATE
LEAD ARSENATE
LEAD ARSENATE
LEAD CHLORIDE
LEAD FLUORIDE
LEAD FLUOROBORATE
LEAD IODIDE
LEAD NITRATE
LEAD STEARATE
LEAD STEARATE
LEAD STEARATE
LEAD STEARATE
LEAD SULFATE
LEAD SULFATE
LEAD SULFIDE
LEAD THIOCYANATE
LEPTOPHOS
LEWISITE
LIGHT NAPATHENIC
LIGHT PARAFFINIC
LIGHT PARAFFINIC
LITHIUM CHROMATE
DISTILLATE
DISTILLATE SO
DISTILLATES
CASNUM
00133-57-3
64742-81-0
07722-84-1
07783-07-5
64742-80-9
05470-11-1
10046-00-1
10039-54-0
07803-49-8
82244-86-8
00053-86-1
71868-10-5
80387-97-9
10025-97-5
07439-89-6
13463-40-6
00297-78-9
00110-19-0
00078-84-2
00079-31-2
00078-82-0
00102-36-3
29761-21-5
00119-06-2
04098-71-9
00078-79-5
25640-78-2
42504-46-1
00067-73-0
00108-23-6
00625-55-8
04016-14-2
00119-38-0
28108-99-8
00099-87-6
12427-38-2
08008-20-6
00078-97-7
02461-18-9
61789-51-3
07784-40-9
07645-25-2
10102-48-4
07758-95-4
07783-46-2
13814-96-5
10101-63-0
10099-74-8
56189-09-4
52652-59-2
07428-48-0
01072-35-1
07446-14-2
15739-80-7
01314-87-0
00592-87-0
21609-90-5
00541-25-3
64742-53-6
64742-05-8
64741-50-0
14307-35-8
SOURCE P1* P2*
OTS 1
OTS 1
AC 1
AC 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS
OTS
AC
OTS
OTS
AC
GWL 1
AC 1
AC 1
HSL 1
NJ 1
HSL 1
OTS 1
AC 1
OTS 1
OTS 1
AC 1
HSL 1
OTS 1
HSL 1
NJ 1
AC 1
AC 1
OTS 1
AC 1
OTS 1
OPP 1
NJ 1
OTS 1
AC 1
OTS
OTS
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
AC
AC
OTS
OTS
OTS
HSL 1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
B-19
-------
Appendix B (continued)
REC #
1175
1176
1177
1178
1179
1180
1181
1182
1183
1184
1185
1186
1187
1188
1189
1190
1191
1192
1193
1194
1195
1196
1197
1198
1199
1200
1201
1202
1203
1204
1205
1206
1207
1208
1209
1210
1211
1212
1213
1214
1215
1216
1217
1218
1219
1220
1221
1222
1223
1224
1225
1226
1227
1228
1229
1230
1231
1232
1233
1234
1235
1236
/ CHEMICAL
LITHIUM HYDRIDE
MAGNESIUM
MALEIC ACID
MALEIC ANHYDRIDE
MANGANESE, TRICARBONYL METHYCY
MELAMINE
MEPHOSFOLAN
MERCAPTOBENZOTHIAZOLE
MERCAPTOBENZOTHIAZOLE(2-} DISU
MERCURIC ACETATE
MERCURIC NITRATE
MERCURIC OXIDE
MERCURIC SULFATE
MERCURIC THIOCYANATE
MERCURIN CYANIDE
HERCUROUS NITRATE
MERCUROUS NITRATE
MERPHOS
MESITYL OXIDE
METHACROLEIN DIACETATE
METHACRYLIC ANHYDRIDE
METHACRYLOYL CHLORIDE
METHACRYLOYLOXYETHYL ISOCYANAT
METHAMIDOHPOS
METHANESULFONYL FLUORIDE
METHIDATHION
METHOXYETHANOL, 2-
METHOXYETHYLMERCURIC ACETATE
METHYL 2-CHLOROACRYLATE
METHYL CARBAMATE
METHYL CHLORIDE
METHYL DISULFIDE
METHYL ETHYL KETOX1ME
METHYL GLYCIDOL ETHER
METHYL ISOTHIOCYANATE
METHYL N-BUTYL KETOHE
METHYL PARAXON
METHYL PHENAKAPTON
METHYL PHOSPHON1C DICHLOLRIDE
METHYL THIOCYANATE
METHYL VINYL KETONE
METHYL-PHENYGLYCIDIC ACID. 3-
METHYLACETONITRILE, 2-
METHYLCYCLOPENTANE
METHYLDIPHENYL PHOSPHATE
METHYLMERCURIC D I CYAN AM IDE
METHYLOLUREA
METHYLTRICHLOROSILANE
METOLACHLOR
METOLCARB
METRIBUZIN
METRIBUZIN DA
METRIBUZIM DADK
METRIBUZIN OK
MGK 264
MICHLER'S KEYTONE
MOLINATE
MOLYBDENUM
MOLYBDENUM TRIOXIDE
MONOBUTYL ETHER
MONOCROTOPHOS
MONOETHYLAMINE
CASNUM
07580-67-8
07439-95-4
00110-16-7
0018-31-6
12108-13-3
00108-78-1
00950-10-7
00149-30-4
00120-78-5
01600-27-7
10045-94-0
21908-53-2
07783-35-9
00592-85-8
00592-04-1
10415-75-5
07782-86-7
00150-50-5
00191-79-7
10476-95-6
00760-93-0
00920-46-7
30674-80-7
10265-92-6
00558-25-8
00950-37-8
00109-86-4
00151-38-2
00080-63-7
00598-55-0
00075-87-3
00624-92-0
00096-29-7
00930-37-0
00556-61-6
00591-76-6
00950-35-6
03735-23-7
00676-97-1
00556-64-9
00078-94-4
05669-15-8
00075-86-5
00096-37-7
00115-89-9
00502-39-6
01000-82-4
00075-79-6
51218-45-2
01129-41-5
21087-64-9
35045-02-4
56507-37-0
52236-30-3
00113-48-4
00090-94-8
02212-67-1
07439-98-7
01313-27-5
09038-95-3
06923-22-4
00075-04-7
SOURCE F
AC
GUL
HSL
HSL
AC
NJ
AC
OTS
OTS
AC
HSL
AC
HSL
HSL
HSL
HSL
HSL
OPP
OTS
AC
AC
AC
AC
AC
AC
AC
NJ
AC
AC
OTS
ous
AC
OTS
OTS
AC
OTS
OPP
AC
AC
AC
AC
OTS
H20
OTS
OTS
AC
OTS
AC
OPP
AC
OPP
OPP
OPP
OPP
OPP
NJ
OPP
SAR
NJ
OTS
AC
HSL
1 P2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1 0
1 0
1 0
1 0
1 0
0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
B-20
-------
Appendix B (continued)
REC #
1237
1238
1239
1240
1241
1242
1243
1244
1245
1246
1247
1248
1249
1250
1251
1252
1253
1254
1255
1256
1257
1258
1259
1260
1261
1262
1263
1264
1265
1266
1267
1268
1269
1270
1271
1272
1273
1274
1275
1276
1277
1278
1279
1280
1281
1282
1283
1284
1285
1286
1287
1288
1289
1290
1291
1292
1293
1294
1295
1296
1297
1298
/ CHEMICAL
MONOMETHYLAMINE
MONUROM
MONURON TCA
HORPHOLINE
HOTRO.-PTROACETOC ACID
N-BUTYLBENZENE
N-DECYL, N-HEXYL PHTHALATE
M-NITROSOOIETHANOLAMINE
N-NITROSOSARCOSINE
N-PENTANE
NALCO 7811
NALEO
NAPHTHENIC ACID
NAPROPAMIDE
NICKEL AMMONIUM SULFATE
NICKEL CHLORIDE
NICKEL CHLORIDE
NICKEL HYDROXIDE
NICKEL NITRATE
NICKEL OXIDE
NICKEL SULFATE
NITRATES/NITRITES
NITRO-0-ANISIDINE,
5-
NITRO-4-BROAMOANILINEC2-)
NITRO-5-CHLOROAN1LINEC2-)
NITROANILINE HYDROCHLORIDEC4-)
NITROBIPHENYL, 4-
NITROCYCLOHEXANE
NITROFEN
NITROGEN DIOXIDE
NITROGEN MUSTARD N-OXIDE AND
NITROGEN OXIDE
NITROPHENOL, M-
NITROQUINOLINE-1-OX1DE 4
NITROSODIPHENYLAMINE, P-
NITROTLUENE, M-
NITROTOLUENE
NITROTOLUENE, 0-
NITROTOLUENE, P-
NONYLPHENOL
NONYLPHENOL
NONYLPHENOLC4-)
NORBORMIDE
NORFLURAZON
OCTAMETHYLCYCLOTETRASI LOXANE
OCTANE
OCTYL DIPHEMYL PHOSPHATE
OLEYLAMINE
OROTIC ACID
OSMIUM
OUABAIN
OXETANE, 3,3,-BIS(CHLOROMETHYL
OZONE
Octachlorostyrene
P-TERT-BUTYLPHENOL
PARAFORMALDEHYDE
PARAQUAT
PHOSPHATE
PARAQUAT METHOSULFATE
PEBULATE
PENTABORANE
PENTABROMOETHYLBENZENE
PENTADECYLAMINE
CASNUM
00074-89-5
00150-68-5
00140-41-0
00110-91-8
00139-13-9
00104-51-8
25724-58-7
01116-54-7
13256-22-9
00109-66-0
42262-66-8
00300-76-5
01338-24-5
15299-99-7
15699-18-0
07718-54-9
37211-05-5
12054-13-3
14216-75-2
01313-99-1
07786-81-4
14797-55-8
00099-59-2
00875-51-4
01635-61-6
15873-51-5
00092-93-3
01122-60-7
01836-75-5
10544-72-6
00302-70-5
10024-97-2
00554-84-7
00056-57-5
00156-10-5
00099-08-1
01321=12-6
00088-72-2
00099-99-0
00104-40-5
25154-52-3
00136-83-4
00991-42-4
27314-13-2
00556-67-2
00111-65-9
00115-88-8
00112-90-3
00065-86-1
07440-04-2
00630-60-4
00078-71-7
10028-15-6
29082-74-4
00078-33-1
30525-89-4
01910-42-5
02074-50-2
01114-71-2
19624-22-7
00085-22-3
02570-26-5
SOURCE P1* P2*
HSL 1
SF 1
SF 1
OTS
NJ
OPP
OTS
H20
RR1
SAR
OTS
HSL
HSL
OPP
HSL
HSL
HSL 1
AC 1
HSL 1
OTS 1
HSL 1
SAR 1
NJ 1
OTS 1
OTS 1
OTS 1
NJ 1
AC 1
NJ 1
HSL 1
RR1 1
OTS 1
HSL 1
RR1 1
NJ 1
HSL 1
HSL 1
HSL . 1
HSL
OTS
OTS
OTS
AC
OPP
OTS
SAR
OTS
OTS
AC
GUL
AC
AC
AC
OTS
OTS
HSL
AC
AC
OPP
AC
OTS
AC
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
B-21
-------
Appendix B (continued)
REC #
1299
1300
1301
1302
1303
1304
1305
1306
1307
1308
1309
1310
1311
1312
1313
1314
1315
1316
1317
1318
1319
1320
1321
1322
1323
1324
1325
1326
1327
1328
1329
1330
1331
1332
1333
1334
1335
1336
1337
1338
1339
1340
1341
1342
1343
1344
1345
1346
1347
1348
1349
1350
1351
1352
1353
1354
1355
1356
1357
1358
1359
1360
/ CHEMICAL
PENTAD I ENE, 1,3-
PENTANEDIONE(2,4-)
PEPERDINYLOX(1-),2,2,6,6-TETRA
PETROLEUM DISTILLATES
PETROLEUM NAPHTHA
PHENOL, 2,2'-THIOBIS (4-DICHLO
PHENOL, 2,2'-THIOBISC4-CHLORO-
PHENOL,3-(1-METHYLETHYL)-METHY
PHENOXARSINE, 10,10' -OXYD1-
PHENOXYETHANOL(2-)
PHENYL GLYCIDOL EHTER
PHENYLACETATE
PHENYLENDIAMINE SULFATE(M-)
PHENYLENEDIAMINE
PHEHYLENEOIAMINE 2,5-OlCHLORO
PHENYLENEDIAMINE DIHYDROCDHLOR
PHENYLENEDIAMINE DIHYDROCHLORI
PHENYLENEDIAMINE HYDROCHLORIDE
PHENYLENEDIAMINE SULFATE(P-)
PHENYLENEDIAMINE(M-),4-CHLORSU
PHENYLENEDIAMINE, 2-CHLOROOIHY
PHENYLENEDIAMINE, 2-NITRO(P->
PHENYLENEDIAMINE, 2-NITRO-(P-)
PHENYLENEDIAMINE, 4-BUTYL-CO-)
PHENYLENEDIAMINE, 4-CHLORO
PHENYLENEDIAMINE, 4-CHLORO-(M-
PHENYLENEDIAMINE, 4-ETHOXY-<0-
PHENYLENEOIAMINE, 4-METHOXYL-
PHENYLENEDIAMINE, 4-NITRO
PHENYLENEDIAMINE, 4-NITRO
PHENYLENEDIAMINE, 4-NITRO-(M-)
PHENYLENEDIAMINE, S-NITRO-(M-)
PHENYLENEDIAMINE. 2-NITRO(M-)
PHENYLENEDIAMINE, 2-NITRODIHYDR
PHENYLENEDIAMINE, 4-NITROSULFAT
PHENYLETHANOL
PHENYLGLYCIDIC ACID, 3-, ETHYL
PHENYLHYDRAZIN HYDROCHLORIDE
PHENYLPHENOL, 2-
PHENYLSILATRANE
PKOSACETIM
PHOSFOLAN
PHOSMET
PHOSPHAMIDON
PHOSPHONOTHIOOIC ACID, METHYL-
PHOSPHONOTHIOIC ACID, METHYL
PHOSPHONOTHIOIC ACID, METHYL-,
PHOSPHORIC ACID, DIMETYL 4-MET
PHOSPHORIC ACID, 1 -METHYL-ETHYL
PHOSPHORUS PENTACHLORIDE
PHOSPHORUS PENTASULFIDE
PHOSPHORUS PENTOXIDE
PHTHALIMIDE
PHTHALIMIDE
PHYLLOQUINONE
PHYSOSTIGMINE
PHYSOSTIGMINE,SALICYLATEU(1:1)
PICLORAM
PICRIC ACID
PICROTOXIN
PIPERIDINE
PIPROTAL
CASNUM
00504-60-9
00123-54-6
02564-83-2
64741-44-2
64741-66-8
00097-18-7
04418-66-0
00064-00-6
00058-36-6
00122-99-6
00122-60-1
00103-45-7
00541-70-8
25265-76-3
20103-09-7
00624-18-0
00615-28-1
00541-69-5
16245-77-5
68239-80-5
00615-46-3
06219-71-2
05307-14-2
03663-23-8
00095-83-0
05131-60-2
01197-37-1
00614-94-8
00099-56-9
00992-59-6
05131-58-8
05042-55-7
06219-67-6
18266-52-9
06219-77-8
00060-12-8
00121-39-1
00059-68-1
00090-43-7
02097-19-0
04104-14-7
00947-02-4
00732-11-6
13171-21-6
50782-69-9
02665-30-7
02703-13-1
03254-63-5
60763-39-5
10026-13-8
01314-80-3
01314-56-3
00085-41-6
00055-41-6
00084-80-0
00057-47-6
00057-64-7
01918-02-1
00088-89-1
00124-87-8
00110-89-4
05281-13-0
SOURCE P
HSL 1
OTS 1
OTS 1
OTS 1
OTS 1
AC 1
AC 1
AC 1
AC 1
OTS 1
OTS 1
OTS 1
OTS 1
RR1 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS 1
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
OTS
AC
NJ
AC
AC
AC
AC
AC
AC
AC
AC
AC
OTS
AC
HSL
AC
OTS
OTS
AC
AC
AC
OPP
NJ
AC
AC
OTS
* *
1 P2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
I 0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1 0
1 0
1 0
1 0
1 0
1 0
B-22
-------
Appendix B (continued)
REC #
1361
1362
1363
1364
1365
1366
1367
1368
1369
1370
1371
1372
1373
1374
1375
1376
1377
1378
1379
1380
1381
1382
1383
1384
1385
1386
1387
1388
1389
1390
1391
1392
1393
1394
1395
1396
1397
1398
1399
1400
1401
1402
1403
1404
1405
1406
1407
1408
1409
1410
1411
1412
1413
1414
1415
1416
1417
1418
1419
1420
1421
1422
/ CHEMICAL
PLAT I NOUS CHLORIDE
PLATINUM TETRACHLORIDE
PLUTONIUM
POLYBROMINATEDBIPHENYLS
POTASSIUM
POTASSIUM ARSENATE
POTASSIUM BICHROMATE
POTASSIUM CHROMATE
POTASSIUM HYDROXIDE
POTASSIUM PERMANGANATE
PRI1M1FOS-ETHYL
PROMECARB
PROPACHLOR
PROPANAL,3,3,3-TRIFLUORO-
PROPANETRIOL(1,2,3-)
PROPANIL
PROPARGITE
PROPARGYL BROMIDE
PROPION-LDEHYDE
PROP I ON 1C ACID
PROPIONIC ANHYDRIDE
PROP I ON I TR RE
PROPYL CHLOROFORMATE
PROPYLBENZENE(N-)
PROPYLENEL GLYCOL, ALLYL EHTER
PROPYLTHIOURACIL
PROTHOATE
PYRETHRINS
PYRETHRINS
PYRETHRINS
PYRIDINE, 2-METYHL-5-VINYL-
PYRIDINE, 4-NITRO, 1 -OXIDE
PYRIMINIL
PYRROLIDINONE (2->, 1-ETHENYL
RADIUM AND COMPOUNDS
RADON AND COMPOUNDS
RDX
-------
Appendix 8 (continued)
REC #
1423
1424
1425
1426
1427
1428
1429
1430
1431
1432
1433
1434
1435
1436
1437
143S
1439
1440
1441
1442
1443
1444
1445
1446
1447
1448
1449
1450
1451
1452
1453
1454
1455
1456
1457
1458
1459
1460
1461
1462
1463
1464
1465
1466
1467
1468
1469
1470
1471
1472
1473
1474
1475
1476
1477
1478
1479
1480
1481
1482
1483
1484
/ CHEMICAL
SLIVEX ESTERS
SODIUM ANTHRAOUINONE-1-SULFONA
SODIUM BICHROMATE
SODIUM 81 FLUORIDE
SODIUM BISULFITE
SODIUM CACOOYLATE
SODIUM CHROMATE
SODIUM DOOECYLBENZENE SULFONAT
SODIUM FLUORIDE
SODIUM HYOROSULFIDE
SODIUM HYPOCHLORITE
SODIUM HYPOCHLORITE
SODIUM METHYLATE
SODIUM N-METHYL-N-OLEYLTAURINE
SXIUM NITRITE
SODIUM PENTACHLORPHENATE
SODIUM PHOSPHATE, DIBASIC
SODIUM PHOSPHATE, TR I BASIC
SODIUM SELENATE
SODIUM SELEMITE
SODIUM SULFATE
SODIUM TELLURITE
STIROFOS
STROBANE
STRONTIUM
STRONTIUM CHROMATE
STRYCHNINE, SULFATE
STYRENE OXIDE
SULFIOE
SULFOXIOE, 3-CHLOROPROPYL OCTY
SULFUR MONOCHLORIDE
SULFUR TETRAFLUORIDE
SULFUR TRIOXIDE
SULFURIC ACID, CADMIUM SALT
T AMINES, 2,4,5-
T ESTERS. 2.4.5-
T SALTS, 2,4,5-
TABUN
TEBUTHIURON
TELLURIUM
TELLURIUM HEXAFLUORIOE
TERBACIL
TERBUTHYLAZINE
TERBUTRYN
TEREPHTHALIC ACID
TERT-BUTYLBENZENE
TERT8UTYL ACETATE
TETRABROMOBISPHENOL A
TETRACHLOROANILINE(2,3,5,6-)
TETRACHLOROBENZENAMINE(2,3,4,5
TETRACHLOROPROPENES
TETRACHLOROPROPENES
TETRACHLORVINPHOS
TETRAETHYLTIM
TETRAMETHYL LEAD
TETRANITROANILINE(2,3,4,6-)
THALLIUM (1) CARBONATE
THALLIUM SELENITE
THALLIUM SULFATE
THALLOUS MALONATE
TH10CARBAZIDE
THIOCYANIC ACID, 2-(BENZOTHIAZ
CASNUM
32534-95-5
00128-56-3
10588-01-9
01333-83-1
07631-90-5
00124-65-2
07775-11-3
25155-31-0
07681-49-4
16721-80-5
10022-70-5
07681-52-9
00124-41-4
00137-20-2
07632-00-0
00131-52-2
07558-79-4
07601-54-9
13410-01-0
07782-82-3
07757-82-6
10102-20-2
22248-79-9
08001-50-1
07440-24-6
07789-06-2
00060-41-3
00096-09-3
18496-25-8
03569-57-1
12771-08-3
07783-60-0
07446-11-9
10124-36-4
02008-46-0
00093-79-8
13560-99-1
00077-81-6
34014-18-1
13494-80-9
07783-80-4
05902-51-2
05915-41-3
00886-50-0
00100-21-0
00098-06-6
00540-88-5
00079-94-7
03481-20-7
00634-83-3
20559-85-9
10436-39-2
00961-11-5
00597-64-8
00075-74-1
03698-54-2
29809-42-5
12039-52-0
10031-59-1
02757-18-8
02231-57-4
21564-17-0
SOURCE
HSL
AC
HSL
HSL
HSL
AC
HSL
HSL
HSL
HSL
HSL
HSL
HSL
OTS
HSL
AC
HSL
HSL
AC
HSL
NJ
AC
OPP
SF
SAR
HSL
AC
NJ
GUL
AC
HSL
AC
AC
OTS
HSL
HSL
HSL
AC
OPP
AC
AC
OPP
SF
OPP
NJ
OPP
HSL
OTS
OTS
OTS
OTS
OTS
NJ
AC
AC
OTS
RR1
RR1
AC
AC
AC
AC
P1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
P2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
B-24
-------
Appendix B (continued)
REC #
1485
1486
1487
1488
1489
1490
1491
1492
1493
1494
1495
1496
1497
1498
1499
1500
1501
1502
1503
1504
1505
1506
1507
1508
1509
1510
1511
1512
1513
1514
1515
1516
1517
1518
1519
1520
1521
1522
1523
1524
1525
1526
1527
1528
1529
1530
1531
1532
1533
1534
1535
1536
1537
1538
1539
1540
1541
1542
1543
1544
1545
1546
/ CHEMICAL
THIOOIANILINE 4,4'-
THIOMETON
THIONAZIN
THIOUREA, (2-HETHYLPHENYL)
THORIUM AND COMPOUNDS
THORIUM DIOXIDE
TITANIUM DIOXIDE
TMBP(1,1,3,3-)
TOLUENE 2,4-DIISOCYANATE
TRANS-HEPTACHLOROSTYRENE
TRANS-PERMETHRIN
TRI-P-CRESYL PHOSPHATE
TRIADEMEFON
TRIAMINPHOS
TRIAZIQUINONE
TRIAZOPHOS
TRIBROMOANILINE(2,4,6-)
TR I BUTYL PHOSPHATE
TRICHLOLROPHENOL
. 3.4.5-
TRICHLORO(CHLOROMETHYL}SILANE
TR I CHLOROCD ICHLOROPHENYL )S I LAN
TR1CHLOROACETYL
CHLORIDE
TRICHLOROANILINE(2,3,4-)
TRICHLOROANILIME(2.4,5-)
TRICHLOROANILINE(2,4,6-)
TRICHLOROBENZEN
(1,2,3-)
TRICHLOROETHYLSILANE
TR I CHLOROFR I FLUOROETHANE
TRICHLORONATE
TRICHLOROPHENOL
TRICHLOROPHENOL,
TRICHLOROPHENOL,
TRICHLOROPHENOL,
2,3,4-
2.3,5-
2,3,6-
TRICHLOROPHENYLSILANE
TRICRESYL PHOSPHATE (0-)
TRICRESYL PHOSPHATE PHTHALENE
TRICYCLAZOLE
TRIESTER WITH GLYCEROL
TRIETHAMOLAMINE
TRIETHOXYSILANE
DODECYLBENZENE
TR I ETHYL PHOSPHATE
TRIETHYL PHOSPHOROTHIOATE (0,0
TRIETHYLAMINE
TRIETHYLENE GLYCOL DIGLYCIDYL
TRIETHYLENE GLYCOL MONOBUTYL
TRIETHYLENE GLYCOL, MONOETHYL
TRIETHYLENE GLYCOL, MONOMETHYL
TRIMETHLYAMINE
TRIMETHYLCHLOROSILANE
TRIMETHYLOLPROPANE PHOSPHITE
TRIHETHYLTIN CHLOLRIDE
TRINITROANILINE(2,4,6-)
TR I N I TROPHENYLMETHYLN I TRAMI NE
TRIPHENYL PHOSPHATE
TRIPHENYL PHOSPHITE
TRIPHENYLTIN CHLORIDE
TRIS(1-AZIRIDINYL)PHOSPHINE SU
TRIS(2-CHLOROETHYL)AMINE
TRIS(2-CHLOROETHYL)PHOSPHITE
TRIS(2-ETHYLHEXYL)TRIMELLITATE
TRIS(ISOPROPYLPHENYL)
TRIS(P-(2,3-EPOXY PROPOXY)PHEN
CASNUM
00139-65-1
00640-15-3
00297-97-2
00614-78-8
07440-29-1
01314-20-1
13463-67-7
00140-66-9
00548-84-9
29086-38-2
51877-74-8
00078-32-0
43121-43-3
01031-47-6
00068-76-8
24017-47-8
00147-82-0
00126-73-8
00609-19-6
01558-21-4
27137-85-5
00076-02-8
00634-67-3
00636-30-6
00634-93-5
00087-61-6
00115-21-9
00000-00-0
00327-98-0
25167-82-2
15950-66-0
00933-78-8
00933-75-5
00098-13-5
00078-30-8
01330-78-5
41814-78-2
00106-81-0
27323-14-7
00998-30-1
00078-40-0
00126-68-1
00121-44-8
01954-28-5
00143-22-6
00112-50-5
00112-35-6
00075-50-3
00075-77-4
00824-11-3
01066-45-1
00489-98-5
00479-45-8
00115-86-6
00101-02-0
00639-58-7
00052-24-4
00555-77-1
00140-08-9
03319-31-1
26967-76-0
06130-72-9
SOURCE PI P2
NJ 1
AC 1
AC
AC
SAR
NJ
NJ
OTS
AC
OTS
OPP
OTS
OPP
AC
NJ
AC
OTS
OTS
HSL
AC
AC
AC
OTS
OTS
OTS
OPP
AC
OTS
AC
HSL
HSL
HSL
HSL
AC
OTS
OTS
OPP
OTS
HSL
AC
OTS
RR1
HSL
OTS
OTS
OTS
OTS
HSL
AC
AC
AC
OTS
SAR
OTS
OTS
AC
RR1
AC
OTS
OTS
OTS
OTS
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
1 0
B-2S
-------
Appendix B (continued)
REC # / CHEMICAL
CASNUN
SOURCE
P1 P2
1547
1548
1549
1550
1551
1552
1553
1554
1555
1556
1557
1558
1559
1560
1561
1562
1563
1564
1565
1566
1567
1568
1569
1570
1571
1572
1573
1574
1575
1576
1577
1578
1579
1580
1581
1582
1583
1584
1585
TRITIUM
TRIX(2,6-XYLENYL) PHOSPHATE
UF RESINS
UF RESINS
URANIUM AND COMPOUNDS
URANYL ACETATE
URANYL NITRATE
URANYL NITRATE
VALINOMYCIN
VAN AD 1C ACID, AMMONIUM SALT
VANAOYL SULFATE
VINYL BROMIDE
VINYLNORBORNENE
WARFARIN SODIUM
XYLENE DICHLORIDE
XYLENES (TOTAL)
XYLENOL
XYLIDINE, 2,6
ZINC ACETATE
ZINC AMMONIUM CHLORIDE
ZINC AMMONIUM CHLORIDE
ZINC AMMONIUM CHLORIDE
ZINC BORATE
ZINC BROMIDE
ZINC CARBONATE
ZINC CHLORIDE
ZINC FLUORIDE
ZINC FORMATE
ZINC HYDROSULFITE
ZINC NITRATE
ZINC OXIDE
ZINC PHENOLSULFATE
ZINC SILICOFLUORIDE
ZINC SULFATE
ZINC, DICHLOLRO(4,4-DIMETHYLAM
ZIRCONIUM NITRATE
ZIRCONIUM POTASSIUM FLUORIDE
ZIRCONIUM SULFATE
ZIRCONIUM TETRACHLORIDE
10028-17-8
00121-06-2
68611-64-3
09011-05-6
07440-61-1
00541-09-3
36478-76-9
10102-06-4
02001-95-8
13718-26-8
27774-13-6
00593-60-2
03048-64-4
00129-06-6
28347-13-9
00133-02-7
01300-71-6
00087-62-7
00557-34-6
52628-25-8
14639-97-5
14639-98-6
01332-07-6
07699-45-8
03486-35-9
07646-85-7
07783-49-5
00557-41-5
07779-86-4
07779-88-6
01314-13-2
00127-82-2
16871-71-9
07733-02-0
58270-08-9
13746-89-9
16923-95-8
14644-61-2
10026-11-6
SAR
OTS
OTS
OTS
SAR
HSL
HSL
HSL
AC
RR1
HSL
NJ
AC
AC
AC
SF
HSL
NJ
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
HSL
OTS
HSL
HSL
HSL
AC
HSL
HSL
HSL
HSL
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
The chemicals are ranked using a main prioritization as well as a subprioritization. The main
prioritization (P1) was determined by the number of Program Offices which listed that chemical on one or
more lists. The subprioritization (P2) was derived by subtracting the main prioritization number from the
total number of lists on which the chemical appeared. Thus, formaldehyde, for example, received a rating of
5.(PI) 3.(P2) because it appeared on 8 lists from 5 different Program Offices. This scoring system provided
a means of ranking chemicals that were listed by the same number of Program Offices (i.e., had identical PI
ratings), and reduced the likelihood of bias toward any particular Program Office as a result of multiple
listings of chemicals by that office.
B-26
-------
APPENDIX C
COMPOUNDS KNOWN TO FORM ADDUCTS
RECNO
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
COMPOUND
FORMALDEHYDE
MITOMYCIN C
17-BETA ESTRADIOL
BENZO(A)PYRENE
CHLORPROMAZINE
ACTINOMYC1N D
METRIFONATE
ACETYLAMINOFLUORENE, 2-
DIETHYLNITROSAMINE
METHYLCHOLANTHRENE, 3-
DIETHYLSTILBESTROL
NITROOUINOLINE-1-OXIDE, 4-
BETA-PROPIOLACTONE
. DIMETHYLBENZANTHRACENE, 7,12-
AMINOAZOBENZENE, 4-
PROMETHAZINE
ETHYLMETHANESULFONATE
THIOACETAMIDE
DICHLORVOS
D1METHYLNITROSAMINE
DIETHYLSULFATE
METHYLMETHANESULFONATE
CHLOROFORM
N-NITROSO-N-METHYL-N'-NITROGUANIDINE
BENZENE
CHLOROMETHANE
VINYL CHLORIDE
ETHYLENE OXIDE
BROMOFORM
1,1-DICHLOROETHANE
PROPYLENE OXIDE
DIMETHYL SULFATE
DIMETHYLCARBAMYL CHLORIDE
DIETHYLCARBAMYL CHLORIDE
NAPHTHALENE, 2-
AMINOBIPHENYL, 4-
BENZIDINE
METHYLEUGENOL
SAFROLE
TOLUDINE, 0-
STYRENE
BENZYL CHLORIDE
NITROSOPIPERADINE
METHYLENEBIS(O-CHLOROANILINE)
ANETHOLE
EPICHLOROHYDRIN
DIBROMOETHANE, 1,2-
CAS. NUMBER
00050-00-0
00050-07-7
00050-28-2
00050-32-8
00050-53-3
00050-76-0
00052-68-6
00053-96-3
00055-18-5
00056-49-5
00056-53-1
00056-57-5
00057-57-8
00057-97-6
00060-09-3
00060-87-7
00062-50-0
00062-55-5
00062-73-7
00062-75-9
00064-67-5
00066-27-3
00067-66-3
00070-25-7
00071-43-2
00074-87-3
00075-01-4
00075-21-8
00075-25-2
00075-34-3
00075-56-9
00077-78-1
00079-44-7
00081-10-8
00091-59-8
00092-67-1
00092-87-5
00093-15-2
00094-59-7
00095-53-4
00100-42-5
00100-44-7
00100-75-4
00101-14-4
00104-46-1
00106-89-8
00106-93-4
C-1
-------
APPENDIX C (Continued)
RECNO
48
49
SO
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
COMPOUND
BROMO-2-CHLOROETHANE, 1-
DICHLOROETHANE, 1,2-
ACRYLONITRILE
DICHIOROOIETHYLETHER, 2,2'-
PROPENE
1SOSAFROLE
TRIS(2,3-DIBROMOPROPYL)PHOSPHAT
ESTRAGOLE
DINITROSOPIPERAZINE
MELPHALAN
ALLYL BENZENE
HYDRAZINE
HONOCROTALINE
ACETYLAMINO-4'-FLUOROBIPHENYL,4-
ELEMICIN
ANGELICIN
DILL APIOL
PARSLEY APIOL
DIHETHYLHYDRAZINE, 1,2-
VINYL BROMIDE
MYRISTICIN
N-NITROSO-N-METHYLURETHANE
N-NITROSO-DI-N-N-PROPYLAHINE
N-METHYL-4-AMINOAZOBENZENE
N-METHYL-N-NITROSOUREA
ETHYLNITROSOUREA
GLYCIDALDEHYDE
1-N-PROPYL-1-NITROSOUREA
TRANS-4-ACETYLAMINOSTILBENE
N,N-BUTYL-N-NITROSOUREA
D I HYDRO- 1 1 -HETHYLCYCLOPENTA-
(A)PHENANTHRENE-17-ONE,
NITROSOPYRROLINE
N - H I TROSOMETHYLBENZYLAM I NE
PROPANE SULTONE, 1,3-
AFLATOXIN B1
NITROSO-2.6-DIMETHYLMORPHOLINE
N-BUTYLMETHANESULFONATE
1-(2-CHLOROETHYL)-1-NITROSOUREA
METHYLCHRYSENE, 5-
TRIMETHYLPSORALEN
ACETYLAMINOBIPHENYL, 4-
ACETYLAMINOPHENANTHRENE, 2-
ANTHRAMYCIN
DIBENZO(A,E)FLUORANTHENE
NITROPYRENE. 1-
HYDROXYLAMINE
STERIGMATOCYSTIN
CAS. NUMBER
00107-04-0
00107-06-2
00107-13-1
00111-44-4
00115-07-1
00120-58-1
00126-72-7
00140-67-0
00140-79-4
00148-82-3
00300-57-2
00302-01-2
00315-22-0
00398-32-3
00487-11-6
00523-50-2
00523-80-8
00523-80-8
00540-73-8
00593-60-2
00607-91-0
00615-53-2
00621-64-7
00621-90-9
00684-93-5
00759-73-9
00765-34-4
00816-57-9
00841-18-9
00869-01-2
00892-17-1
00930-55-2
00937-40-6
01120-71-4
01162-65-8
01456-28-6
01912-32-9
02365-30-2
03697-24-3
03902-71-4
04075-79-0
04120-77-8
04803-27-4
05385-75-1
05522-43-0
07803-49-8
10048-13-2
C-2
-------
APPENDIX C (Continued)
RECNO
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
COMPOUND
NITROSOMETHYLMETHYLAMINE
SIBIROMYCIN
1-CHLOROETHYL-3-CYCLOHEXYL-1-
NITROSOUREA
ETHIONINE
DIMETHYL-4-AMINOBIPHENYL, 3,2'-
1-<2-FLUOROETHYL)-3-CYCLOHEXYL-1-
NITROSOUREA
TRANS-D I AHH I NED I CHLOROPLAT I NUM
C I SPLAT IN
N-NITROSONORNICOTINE
GYROMITRIN
1-NITROSO-5.6-DIHYDROURACIL
STREPTOZOTOCINE
N-BENZYL-2-NITRO-1-IMIDAZOLEACETAMIDE
ADRIAMYCIN
BROMOMETHYLBENZANTHRACENE, 7-
Z-ETHYL ONN AZOXYMETHANE
ETHYLNITROSOGUANIDINE
TOMAMYC1N
N-NITROSO-2-OXOPROPYLAHINE
DINITROPYRENE, 1,8-
NITROS08IS(2-HYDROXYPROPYL)AHINE
N-NITROSOBIS(2-OXOPROPYL)AHINE
NITROSO(2-HYDROXYPROPYL)
(2-OXOPROPYD-AMINE
ANTHROYLOXIRANE, 9-
AMINO-1-HETHYL-5H-PYRIDO
(4,3-B)INDOLE, 3-
N-NITROSOMETHYL(4-METHYLBENZYL)AMINE
4-(METHYLNITROSAMINO)-1-
(3-PYR IDYL)- 1 -BUTANONE
1-(2-CHLOROETHYL)-3-
(CIS-2-HYDROXY)CYCLOHEXYL-1-NI
AMINO-6-METHYLDIPYRIDOC1 ,2-A:3' )
IMIDAZOLE, 2-
AZABENZO(A)PYRENE-4,5-OXIDE, 10-
CC- 106569866-21 -3
METHYLISOPSORALEN, 5-
2-AMINO-3-METHYLIMIDAZO
(4,S-F)OUINOLINE
MITOZOLAMIDE
I-CHLOROETHYL(METYLSULFONYL)
ETHANESULFONATE
N-<2-OXOPROPYL)-N-NITROSOUREA
N-NITROSO-N-ACETOXY-N-2-OXOPROPYLAHINE
CAS. NUMBER
10595-95-6
12684-33-2
13010-47-4
13073-35-3
13394-86-0
13908-93-5
14913-33-8
15663-27-1
16543-55-8
16568-02-8
16813-36-8
18883-66-4
22994-85-0
23214-92-8
24961-39-5
25843-45-2
29169-14-0
35050-55-6
39603-54-8
42397-65-9
53609-64-6
60599-38-4
61499-28-3
61695-73-6
62450-07-1
62783-50-0
64091-91-4
66052-62-8
67730-11-4
67977-01-9
73459-03-7
76180-96-6
85622-95-3
88343-72-0
89837-93-4
89837-94-5
C-3 .
-------
APPENDIX D
PRIORITIZED CHEMICALS OF INTEREST TO THE EPA KNOWN OR SUSPECTED TO FORM ADDUCTS
REC * COMPOUND
CAS.NUMBER
SOURCE
PI P2
M U 1 BENZENE
+ * - 2 VINYL CHLORIDE
* * - 3 FORMALDEHYDE
+ * - 4 ETHYLENE OXIDE
* * 5 ETHYLENE DICHLORIDE
+ * 6 CHLOROFORM
- 7 CHLOROMETHANE
• 8 TRIBROMOMETHANE
- 9 NITROSODIMETHYLAMINE, N-
* - 10 1,1-DICHLOROETHANE
* * 11 STYRENE
• 12 DIBROMOETHANE, 1,2-
- 13 N-N1TROSOOIETHYLAMINE
- 14 GLYCIDALDEHYDE
* 15 ACRYLONITRILE
* 16 DICHLOROETHYL ETHER
M U 17 BENZO(A)PYRENE
M * 18 BENZIDINE
* * - 19 EPICHLOROHYDRIN
- 20 HYDRAZINE
- 21 PROPYLNITROSAMINE, DI-N-
• 22 ACETAMIDE,
N-9H-FLUOREN-2-YL
M • 23 METHYLCHOLANTHRENE, 3-
M * 24 BENZ(A)ANTHRACENE,
7,12-DIMETHYL
• - 25 PROPYLENE OXIDE
26 NAPHTHYLAMINE, 2-
U 27 SAFROLE
U * 28 NITROSOPIPERIDINE, N-
+ * 29 METHYLENEBIS
(2-CHLOROANILINE) 4,4'
U 30 ISOSAFROLE
31 TRIS(2,3-DIBROMOPROPYL)
PHOSPHATE
M * 32 AMINOBIPHENYL, 4-
T 33 3 MELPHALAN
• 34 DIMETHYLHYDRAZINE, 1,2-
U 35 NITROSOPYRROLIDINE, N-
- 36 CARBAMIC ACID,
METHYLNITROSO-,
ETHYL ESTER
- 37 DIMETHYL SULFATE
T 38 THIOACETAMIDE
- 39 DICHLORVOS
00071-43-2 AIR,GWL,HSL,NJ,OPP,OTS,RR1,RUL,SF 6. 3.
00075-01-4 AIR,GWL,HSL,NJ,OPP,OTS,RR1,SF 6. 2.
00050-00-0 ACUTE,AIR,H20,HSL,NJ,OTS,RR1,RUL 5. 3.
00075-21-8 ACUTE,AIR,GWL,HSL,NJ,OTS,RR1,RUL 5. 3.
00107-06-2 AIR,GWL,HSL,NJ,OPP,RR1,RUL,SF 5. 3.
00067-66-3 ACUTE,AIR,GUL,HSL,NJ,RR1,RUL,SF 4. 4.
00074-87-3 GWL,HSL,NJ,OTS,RR1,RUL,SF 4. 3.
00075-25-2 GUL,HSL,NJ,OPP,OSU,RR1,SF 4. 3.
00062-75-9 ACUTE,GWL,HSL,NJ,OTS,RR1 4. 2.
00075-34-3 GWL,HSL,OPP,OSU,RR1,SF 4. 2.
00100-42-5 AIR,GUL,HSL,NJ,OPP,SF 4. 2.
00106-93-4 GWL,HSL,NJ,OPP,RR1,RWL 4. 2.
00055-18-5 GUL,HSL,NJ,OTS,RR1 4. 1.
00765-34-4 H20,HSL,OTS,OSW,RR1 4. 1.
00107-13-1 ACUTE,OWL,HSL,NJ,OTS,RR1,RUL 3. 4.
00111-44-4 ACUTE,GUL,HSL,NJ,RR1,RWL,SF 3. 4.
00050-32-8 GUL,HSL,RR1,RUL,SF 3. 2.
00092-87-5 GWL,HSL,NJ,RR1,RWL 3. 2.
00106-89-8 ACUTE,HSL,NJ,OTS,RR1 3. 2.
00302-01-2 ACUTE,H20.HSL.NJ.RR1 3. 2.
00621-64-7 GWL,HSL,NJ,RR1,SF 3. 2.
00053-96-3 GWL,HSL,NJ,RR1 3. 1.
00056-49-5 GUL,HSL,RR1,RWL 3. 1.
00057-97-6 GWL,HSL,RR1,RWL 3. 1.
00075-56-9 ACUTE,AIR,NJ.OTS 3. 1.
00091-59-8 GUL,HSL,NJ,RR1 3. 1.
00094-59-7 GUL,HSL,NJ,RR1 3. 1.
00100-75-4 GUL.HSL.NJ.RRI 3. 1.
00101-14-4 GUL,HSL,NJ,RR1 3. 1.
00120-58-1 GUL,HSL,OSU,RR1 3. 1.
00126-72-7 GWL,HSL,NJ,RR1 3. 1.
00092-67-1 GUL.NJ.RR1 3. 0.
00148-82-3 H20,HSL,RR1 3. 0.
00540-73-8 H20.HSL.RR1 3. 0.
00930-55-2 GWL.HSL.RR1 3. 0.
00615-53-2 H20,HSL,RR1, 3. 0.
00077-78-1 ACUTE,HSL.NJ.RR1 2. 2.
00062-55-5 HSL.NJ.RR1 2. 1.
00062-73-7 ACUTE,HSL.OPP 2. 1.
D-1
-------
APPENDIX 0. (Continued)
REC *
* * 40
* 41
- 42
- 43
. 44
- 45
- 46
- 47
U 48
49
M * 50
- 51
- 52
- 53
- 54
* 55
• 56
T 57
• 58
• 59
60
61
» • 62
- 63
COMPOUND
DIMETHYLCARBAMOYL
CHLORIDE
BENZYL CHLORIDE
N-NITROSO-N-ETHYLUREA
PROPANE SULTONE, 1,3-
DIETHYLSTILBESTROL
ETHYLMETHANESULFONATE
METHYLMETHANESULFONATE
METHYL-N'-NITRO-N-
NITROSOGUANIDINE, N
PROPYLENE
N-NITROSOMETHYL-
ETHYLEAMINE
N-NITROSONORNICOTINE
STREPTOZOTOCIN
TRICLOROPHON
CARBAMIDE, N-METHYL-
N-NITROSO
BETA-PROPIOLACTONE
TOLUIDINE, 0-
N1TROQUINOLINE-1-OXIDE, 4-
MITOMYCIN C
AM1NOAZOBENZENE, 4-
DIETHYL SULFATE
BROMO( 1 - ) , 2-CHLOROETHANE
VINYL BROMIDE
AFLATOXIN B1
HYDROXYLAMINE AND ITS SALT
CAS. NUMBER
00079-44-7
00100-44-7
00759-73-9
01120-71-4
00056-53-1
00062-50-0
00066-27-3
00070-25-7
00115-07-1
10595-95-6
16543-55-8
18883-66-4
00052-68-6
00684-93-5
00057-57-8
00095-53-4
00056-57-5
00050-07-7
00060-09-3
00064-67-5
00107-04-0
00593-60-2
01162-65-8
07803-49-8
SOURCE1
HSL.NJ.RR1
ACUTE, HSL.RR1
HSL,NJ,RR1
HSL.NJ.RR1
HSL.RR1
HSL.RR1
GUL.RR1
HSL.RR1
AIR.NJ
GUL.RR1
NJ.RR1
HSL.RR1
ACUTE, HSL.NJ
HSL.NJ.RR1
ACUTE. NJ
NJ.RR1
RR1
ACUTE
NJ
NJ
OTS
NJ
RR1
OTS
P1
2.
2.
2.
2.
2.
2.
2.
2.
2.
2.
2.
2.
1.
1.
1.
1.
1.
1.
1.
1.
1.
1.
1.
1.
P2
1.
1.
1.
1.
0.
0.
0.
0.
0.
0.
0.
0.
2.
2.
1.
1.
0.
0.
0.
0.
0.
0.
0.
0.
research established to support their selection
See Appendix A for complete definition of sources.
Indicates those chemicals that have a fair amount of
as potential candidates.
Indicates those chemicals that were thought to have good probability of finding well-defined exposed
populations.
Represents candidate chemicals with supportive adduct research data as well as a good probability of
finding well-defined exposed populations.
Represents chemicals that were initially eliminated due to difficulty in analysis identification resulting
from chemicals that alklylate DNA or proteins via methyl or ethyl groups, induce methyl at ion by other
mechanisms, or form small adducts. Some of these chemicals were reconsidered later.
Refers to those chemicals eliminated due to a nonexistent or relatively small exposed population or no
available clear population data.
Indicates those chemicals that were considered to be so ubiquitous in nature as to confound any useful
relationship between exposure source and health effects.
Refers to chemicals that typically occur as a component of mixtures, and for which exposure to the
individual agent by itself is rare.
Designates those chemicals that have been tabled for an alternate study.
D-2
-------
APPENDIX E
ADOUCT-FORMING CHEMICALS NOT ON EPA LIST
REC *
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
SO
51
52
53
54
55
56
57
58
59
60
COMPOUND
17-BETA ESTRADIOL
CHLORPROHAZINE
ACTINOMYCIN D
PROMETHAZINE
DIETHYLCARBAMYL CHLORIDE
METHYLEUGENOL
ANETHOLE
ESTRAGOLE
DIN1TROSOPIPERAZINE
ALLYL BENZENE
MONOCROTALINE
ACETYLAMINO-4'-FLUOROBIPHENYL, 4-
ELEMICIN
ANGELICIN
DILL APIOL
PARSLEY APIOL
MYRISTICIN
N-METHYL-4-AMINOAZOBENZENE
1-N-PROPYL-1-NITROSOUREA
TRANS-4-ACETYLAMINOSTIL8ENE
N.N-BUTYL-N-NITROSOUREA
D I HYDRO- 1 1 -METHYLCYCLOPENTA( A)
PHENANTHRENE-17-ONE,
N-NITROSOHETHYLBENZYLAHINE
NITROSO-2.6-DIMETHYLMORPHOLINE
N - BUTYLMETHANESUL FONATE
1-(2-CHLOROETHYL)-1-NITROSOUREA
METHYLCHRYSENE, 5-
TRIMETHYLPSORALEN
ACETYLAMINOBIPHENYL, 4-
ACETYLAHINOPHENANTHRENE, 2-
ANTHRAMYCIN
DIBENZO(A,E)FLUORANTHENE
NITROPYRENE, 1-
STERIGMATOCYSTIM
SIBIROMYCIN
1-CHLOROETHYL-3-CYLOHEXYLL-1-NITROSOUREA
ETHIONINE
DIMETHYL-4-AMINOBIPHENYL, 3.2'-
1-<2-FLUOROETHYL)-3-CYCLOHEXYL-1-NITROSOUREA
TRANS-DIAMMINEDICHLOROPLATINUM
C I SPLAT IN
GYROMITRIN
1-NITROSO-5.6-DIHYDROURACIL
N-BENZYL-2-NITRO-1-IMIDAZOLEACETAMID6
ADR1AMYC1N
BROMOMETHYLBENZANTHRACENE, 7-
Z- ETHYL OWN AZOXYMETHANE
ETHYLNITROSOGUANIDINE
TOMAMYCIN
N-N1TROSO-2-OXOPROPYLAMINE
DINITROPYRENE, 1,8-
NITROS08IS(2-HYDROXYPROPYL)AMINE
N-NITROSOBIS(2-OXOPROPYL)AMINE
NITROSO(2-HYDROXYPROPYL)(2-OXOPROPYL)-AMINE
ANTHROYLOXIRANE, 9-
AMINO-1-METHYL-5H-PYRIDO(4,3-B)INDOLE, 3-
N-NITROSOMETHYL(4-HETHYLBENZYL)AMINE
4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE
1-(2-CHLOROETHYL)-3-(CIS-2-HYDROXY)
CYCLOHEXYL-1-NI
AMINO-6-METHYL DIPYRlDOd^-AtS^lMlDAZONE, 2-
CAS. NUMBER
00050-28-2
00050-53-3
00050-76-0
00060-87-7
00081-10-8
00093-15-2
00104-46-1
00140-67-0
00140-79-4
00300-57-2
00315-22-0
00398-32-3
00487-11-6
00523-50-2
00523-80-8
00523-80-8
00607-91-0
00621-90-9
00816-57-9
00841-18-9
00869-01-2
00892-17-1
00937-40-6
01456-28-6
01912-32-9
02365-30-2
03697-24-3
03902-71-4
04075-79-0
04120-77-8
04803-27-4
05385-75-1
05522-43-0
10048-13-2
12684-33-2
13010-47-4
13073-35-3
13394-86-0
13908-93-5
14913-33-8
15663-27-1
16568-02-8
16813-36-8
22994-85-0
23214-92-8
24961-39-5
25843-45-2
29169-14-0
35050-55-6
39603-54-8
42397-65-9
53609-64-6
60599-38-4
61499-28-3
61695-73-6
62450-07-1
62783-50-0
64091-91-4
66052-62-8
67730-11-4
E-1
-------
APPENDIX E (Continued)
REC #
COMPOUND
CAS.NUMBER
61
62
63
64
65
66
67
68
AZABENZO(A)PYRENE-4>5-OXIDE, 10-
CC-1065
METHYL I SOPSORALEN, 5-
2-AMINO-3-METHYL IMIDAZO(4,5-F)QUINOLINE
HITOZOLAMIDE
1-CHLOROETHYL(METYLSULFONYL)METHAHESULFONATE
N-(2-OXOPROPYL)-N-NITROSOUREA
N-NITROSO-N-ACETOXY-N-2-OXOPROPYLAM1NE
67977-01-9
69866-21-3
73459-03-7
76180-96-6
85622-95-3
88343-72-0
89837-93-4
89837-94-5
E-2
-------
APPENDIX F
CARCINOGENIC CHEMICALS NOT KNOWN TO FORM ADDUCTS
REC.NO.
1
2
3
i>
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
COMPOUND
COKE OVEN EMISSIONS
CONJUGATED ESTROGENS
SOOTS, TARS AND MINERAL OILS
BERYL ORE
CARRAGEENAN
CYCLOPHOSPHAHIDE
DDTd
RESERPINE
PROPYLTHIOURACIL
MECHLORETHAMINE
URETHANE
THIOTEPA
ESTRONE
DIBENZ(A,H)ANTHRACENE
MYLERAN
METHYLTHIOURACIL
CARBON TETRACHLORIDE
BENZ(A)ANTHRACENE
DIMETHYL HYDRAZINE, 1,1-
PHENYTOIN AND SODIUM SALT OF
PHENYTOIN
ETHYENYL ESTRAD10L
PROGESTERONE
TESTOSTERONE AND ITS ESTERS
LINDANE AND OTHER ISOMERS OF
HEXACHLOROCYCLOHEXANE
PHENOXYBENZAMINE AND ITS HYDRO-
CHLORIDE
N-NITROSOMORPHOLINE
DIMETHYLAMINOAZOBENZENE, 4-
NIR1DAZOLE
AMITROLE
PHENACETIN
THIOUREA
URACIL MUSTARD
MESTRANOL
TRYPAN BLUE (COMMERCIAL GRADE)
METHYL IODIDE
PROPYLENE1MINE
SACCHARIN
AMINO-2-METHYLANTHRAQUINONE.1-
TRICHLOROPHENOL, 2,4,6-
ANISIDINE, 0- AND 0-ANISIDINE.HCL
MICHLER'S KETONE
DICHLOROBENZIDINE, 3,3'-
NITR08IPHENYL 4-
DIHYDROSAFROLE
SULFALLATE
DIAMINOTOLUENE, 2,4-
CHLORO-0-PHENYLENEDIAMINE, 4-
DIBROMO-3-CHLOROPROPANE. 1,2-
ETHYLENE THIOUREA
AMINOAZOTOLUENE, 0-
BENZOTR I CHLORIDE
NITRO-0-ANISIDINE 5-
METHYLENEDIANILINE 4,4'
DIAMINOOIPHENYL ETHER, 4,4'-
CHLOROMETHYL METHYL ETHER
(TECH GRADE)
NITROPROPANE, 2-
CAS. NUMBER
*****.**.
*****.**.
*****.**.
*****.**.
*****.»*.
00050-18-0
00050-29-3
00050-55-5
00051-52-5
00051-75-2
00051-79-6
00052-24-4
00053-16-7
00053-70-3
00055-98-1
00056-04-2
00056-23-5
00056-55-3
00057-14-7
00057-41-0
00057-63-6
00057-83-0
00058-22-0
00058-8-9
00059-86-1
00059-89-2
00060-11-7
00061-57-4
00061-82-5
00062-44-2
00062-56-6
00066-75-1
00072-33-3
00072-57-1
00074-88-4
00075-55-8
00081-07-2
00082-28-0
00088-06-2
00090-04-0
00090-94-8
00091-94-1
00092-93-3
00094-58-6
00095-06-7
00095-80-7
00095-83-0
00096-12-8
00096-45-7
00097-56-3
00098-07-7
00099-59-2
00101-77-9
00101-81-4
00107-30-2
00108-03-2
F-1
-------
APPENDIX F. (continued)
REC.NO.
COMPOUND
CAS.NUMBER
57 AZASERINE
58 N-NITROSOOIETHANOLAMINE
59 AHINOANTHRAQUINONE, 2-
60 DK2-ETHYLHEXYDPHTHALATE
61 HEXACHLOROBEHZENE
62 DIMETHOXYBENZIDINE, 3,3'-
63 DIMETHYL BENZIDINE, 3,3'-
64 CRESIDINE, P-
65 HYDRAZOBENZENE
66 DIOXANE, 1,4-
67 METHYL-1-NITROANTHRAOUINONE 2-
68 CUPFERRON
69 PHENAZOPYRIDIME AND ITS HYDRO-
CHLORIDE
70 NITRILOTRIACETIC ACID
71 THIODIANILINE, 4,4'-
72 5-(MORPHOLINOMETHYL)-3-«5-NITRO-
FURFURYLIDENE)-AM
73 ARAMITE
74 CHLORDECONE
75 ETHYLENEIMINE
76 NITROSOOIPHENYLAMINE P-
77 DIBENZO(A,I)PYRENE
78 DIBENZO(A,H)PYRENE
79 DIBENZO(A,L)PYRENE
80 DIBENZO(A,E)PYRENE
81 INDENO(1,2,3-CD)PYRENE
82 DIBENZO(C,G)CARBAZOLE, 7H-
83 8ENZO(J)FLUORANTHENE
84 BENZO(B)FLUORANTHENE
85 BENZO(K)FLUORANTHENE
86 DIBENZ(A,J)ACRIDINE
87 DIBENZ(A,H)ACRIDINE
88 METHOXASALEN WITH ULTRAVIOLET A
THERAPY (PUVA)
89 TREOSULFAN
90 LEAD ACETATE
91 NITROGEN MUSTARD N-OXIDE
92 LASIOCARPINE
93 CHLORAMBUCIL
94 PROCARBAZINE
95 OXYMETHOLONE
96 METRONIDAZOLE
97 AZATHIOPRINE
98 AURAMINE
99 CHLORNAPAZINE
100 MUSTARD GAS
101 MERPHALEN
102 N-(4-(5-NITRO-2-FURYL)-2-
THIAZOLYDACETAMIDE
103 BIS(CHLOROMETHYL)ETHER
104 IDAZOLIDINONE.1-
(S-NITROFURFURYLIDENE)AMINO, 1-
105 PANFAN S
106 TOLUENE 2,4-DIISOCYANATE
107 METHAZOXYMETHANOL
108 NITRCENAPHTHENE 5-
109 DIACYL BENZIDINE, N,N'-
110 HEXATHYLPHOSPHORAMIDE
111 AMIN5-(5-NITRO-2-FURYL)-1,3.
4-THIADIAZOLE, 2-
00115-
00116-
00117-
00117-
00118-
00119-
00119-
00120-
00122-
00123-
00129-
00135-
02-6
54-7
79-3
81-7
74-4
90-4
93-7
71-8
66-7
91-1
15-7
20-6
00136-40-3
00139-13-9
00139-65-1
00139-91-3
00140-57-8
00143-50-0
00151-56-4
00156-10-5
00189-55-9
00189-64-0
00191-30-0
00192-65-4
00193-39-5
00194-59-2
00205-82-3
00205-99-2
00207-08-9
00224-42-0
00226-36-8
00298
00299
00301
00302
00303
00305
00366
00434
00443
00446
00492
00494
00505
00531
81-7
75-2
•04-2
•70-5
•34-4
•03-3
•70-1
•07-1
•48-1
86-6
•80-8
•03-1
•60-2
•76-0
00531-82-8
00542-88-1
00555-84-0
00556-12-7
00584-84-9
00592-62-1
00602-87-9
00613-35-4
00680-31-9
00712-68-5
F-2
-------
APPENDIX F. (continued)
REC.NO.
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
COMPOUND
METHLENE BIS(2-METHYLANILINE) 4,4'
N-NITROSOOI-N-BUTYLAMINE
BERYLLIUM OXIDE
CADMIUM OXIDE
CADMIUM SULFIDE
THORIUM DIOXIDE
ASBESTOS
LEAD SUB ACETATE
DIEPOXYBUTANE
DIETHYL HYDRAZINE, 1.2-
BENZYL VIOLET 4B
2,3,7,8-TCDD
NITROFEN
DIRECT BLACK 38
MIREX
DIRECT BLUE 6
ORANGE OIL SS
BUTRYOLACTONE, BETA-
NICKEL CARBONATE
PONCEAU 3R
FORMYLHYDRAZ I NO-4 ( 5 - N I TRO-
2FURYDTHIAZOLE
AF-2
PONCEAU HX
NAFENOPIN
DACARBAZINE
N-NITROSOMETHYLVINYLAMINE
CITRUS RED NO. 2
LEAD
NICKEL
ARSENIC AND COMPOUNDS
BERYLLIUM
CADMIUM
CHROMIUM AND COMPOUNDS
LEAD PHOSPHATE
SELENIUM SULFIDE
BERYLLIUM CHLORIDE
BERYLLIUM FLUORIDE
TOXAPHENE
IRON DEXTRAN COMPLEX
CADMIUM CHLORIDE
CADMIUM SULFATE
NICKEL SUBSULFIDE
NICKEL HYDROXIDE
BERYLLIUM ALUMINUM ALLOY
N-NITROSOSARCOSINE
BERYLLIUM HYDROXIDE
NICKEL CARBONYL
BERYLLIUM SULFATE
BERYLLIUM PHOSPHATE
CYCASIN
ZINC BERYLLIUM SILICATE
DAUNOMYCIN
OICHLORO-4,4'-DIAMINODIPHENYL ETHER,
3,3'-
DIAMINOANISOLE SULFATE, 2,4-
TRANS-2-(DIMETHYLAMINOMETHYLIMINO)5-
(2-5-NITRO-2-
TRP-P-1
CAS. NUMBER
00838-88-0
00924-16-3
01304-56-9
01306-19-0
01306-23-6
01314-20-1
01332-21-4
01335-32-6
01464-53-5
01615-80-1
01694-09-3
01746-01-6
01836-75-5
01937-37-7
02385-85-5
02602-46-2
02646-17-5
03068-88-0
03333-67-3
03564-09-8
03570-75-0
03688-53-7
03761-53-3
03771-19-5
04342-03-4
04549-40-0
06358-53-8
07439-92-1
07440-02-0
07440-38-2
07440-41-7
07440-43-9
07440-47-3
07446-27-7
07488-56-4
07787-47-5
07787-49-7
08001-35-2
09004-66-4
10108-64-2
10124-36-4
12035-72-2
12054-48-7
12770-50-2
13256-22-9
13327-32-7
13463-39-3
13510-49-1
13598-15-7
14901-08-7
15191-85-2
20830-81-3
28434-86-8
39156-41-7
55738-54-0
62450-06-0
F-3
-------
APPENDIX G
ADDUCT-FORMING CARCINOGENIC CHEMICALS NOT ON EPA LIST
RECORD COMPOUND CAS.NUMBER
1 17-BETA ESTRADIOL 00050-28-
2 ACTINOMYCIN D 00050-76-
3 MONOCROTALINE 00315-22-0
4 METHYLCHRYSENE, 5- 03697-24-
5 STERIGMATOCYSTIN 10048-13-2
6 1-CHLOROETHYL-3-CYCLOHEXYL-
1-NITROSOUREA 13010-47-4
7 GYROMITRIN 16568-02-8
8 ADRIAMYCIN 23214-92-8
9 AMINO-1-METHYL-5H-PYRIDO-
<4,3-B)INDOLE. 3- 62450-07-1
G-1
-------
APPENDIX H
NON-ADDUCT-FORMING CHEMICALS SCORED FOR
AVAILABILITY OF AN EXPOSED POPULATION SUITABLE FOR STUDY.
CHEMICAL SCORE
NITROUS OXIDE 108
METHYLENE CHLORIDE 72
METHYL BROMIDE 54
2,4-TOLUENE DIISOCYANATE 54
TRICHLOROETHYLENE 54
PERCHLOROETHYLENE 54
PENTACHLOROPHENOL 54
POLYCHLORINATED BIPHENYLS 54
HALOGENATED ANESTHETICS 36
2.4-DICHLOROPHENOXY A 36
ACRYLAMIDE 36
MCPA 24
1,1,1-TRICHLOROETHANE 24
N-NITROSODIPHENYLAHINE 24
ETHYLENE THIOUREA 16
1,3-DICHLOROPROPENE 12
PARA-CRESOL 12
MALATHION 2
H-1
-------
APPENDIX I
CHEMICALS CHARACTERIZED FOR THEIR POTENTIAL HUMAN EXPOSURE
CAS. NUMBER
107-13-1
75-21-8
100-42-5
75-01-4
74-87-3
75-097-2
50-00-0
74-83-94
86-87-5
127-18-4
4891-66-1
79-01-6
75-35-4
106-89-8
79-06-1
100-44-7
94-75-7
77-78-1
301-01-2
75-56-9
67-66-3
86-30-6
94-74-6
101-14-4
71-55-6
96-45-7
542-75-6
106-44-5
95-53-4
121-75-5
107-02-8
.92-67-1
1162-65-8
542-88-1
56-55-3
71-43-2
92-87-5
50-32-8
57-57-8
1333-86-4
56-23-57
54-74-9
53-70-3
96-12-8
79-44-7
57-14-7
106-93-4
118-74-1
505-60-2
1836-75-5
76-01-7
96-09-3
93-76-5
126-72-7
CHEMICAL
acrylonitrile
ethytene oxide
nit rous ox i de
styrene
vinyl chloride
methyl chloride
methylene chloride
formaldehyde
methyl bromide
pentach lorophenol
perch loroethylene
polychlonnated byphenyls
2,4-toluene diisocyanate
t rich loroethylene
vinylidene chloride
epichlorohydrin
aery I amide
benzyl chloride
2,4-D
dimethyl sulfate
halogenated anesthetics (iso-
flurane, enflurane, halothane)
hydrazine
propylene oxide
chloroform
N-nitrosodiphenylamine
MCPA
4,4'-methylenebis(2-chloro-
aniline) (MOCA)
1,1,1-trichloroethane
n.n'-ethylene thiourea
1 ,3-dichloropropene
para-cresol
o-toluidine
ma lath ion
acrolein (2-propenal)
4-amino-1,1'-biphenyl
aflatoxin b1
bis(chloromethyl) ether
benz(a)anthracene
benzene
benzidine
benzo(a)pyrene
beta-propiolactone
carbon black
carbon tetrachloride
chlordane
dibenz(a,h)anthracene
dibromochloropropane (DBCP)
dimethylcarbaitioyl chloride
1,1-dimethylhydrazine
ethylene dibromide
hexach lorobenzene
mustard gas
nitrofen
pentach loroethane
polybrominated biphenyls
styrene oxide
2,4,5-T
tris(2,3-dibromopropyl)phosphate
SCORE
108
108
1 no
108
108
108
72
72
54
54
54
54
CI
D*>
54
54
54
48
36
36
36
36
36
36
36
24
24
24
24
24
16
12
12
6
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1-1
-------
Appendix I (continued)
CAS.NUMBER
CHEMICAL
SCORE
10034-93-2
10048-13-2
101-25-7
102-71-6
103-23-1
106-34-3
11006-33-0
11056-06-7
11-92-2
1120-71-4
117-81-7
119-34-6
119-93-7
1195-67-1
1195-69-3
123-33-1
126-07-8
127-07-1
128-44-9
129-49-7
13010-47-4
13056-98-9
1306-23-6
13073-35-3
133-06-2
133-07-3
13416-48-3
135-20-6
135-49-9
136-35-6
137-26-8
139-13-9
140-79-4
1402-68-2
14073-00-8
141-28-6
142-04-1
146-54-3
146-59-8
1464-53-5
U7-84-2
U7-94-4
148-82-3
151-56-4
153-78-6
15663-27-1
1582-09-8
16427-45-5
16543-55-8
16672-87-0
hydrazine sulfate
sterigmatocystin
dinitrosopentamethylene
tetramine
triethanolamine
octyl adipate
quinhydrone
phleomycin
bleomycin
dibutylamine
propane suitone
bis(2-ethylhexyl) phthalate
c.i. oxidation base 25
totidine (c.i. azoic diazo
component 113)
p-(1-aziridinyl)-n,n,n',n'-
tetramethylphosponic diamide
p,p-bis(1-aziridinyl)-n,n-
dimethylphosphinic amide
maleic hydrazide
griseofulvin
hydroxyyrea
saccharin sodium
methysergide hydrogen maleate
1-(2-chloroethyl)-3-cyclohexyl-
1-nitrosourea
1-phenyl-3,3-diethyltriazene
c.i. pigment yellow
(cadmium sulfide)
L-ethionine
captan
folpet
2-(1-aziridinyl)-4,6-dimethoxy-
1.3.5-triazine
cupferron
acridine yellow
diazoaminobenzene
thiram
nitrilotriacetic acid
1,4-dinitrosopiperazine
afIatoxins
3-methyl-4-nitroquinoline
1-oxide
ethyl adipate
aniline hydrochloride
triflupromazine
acridine mustard
1,2:3,4-diepoxybutane
diethyldithiocarbamic acid
cytarabine
(cytosine arabinoside)
melphatan
ethylenimine
2-aminofluorene
cis-diamine-dichloro-
platinun(Il)
trifluralin
diethyl 1,3-propanedisolfonate
N-nitrosonornicotine
(Z-chloroethyl)phosphonic acid
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
1-2
-------
Appendix I (continued)
CAS.NUMBER
CHEMICAL
SCORE
1836-75-5
1897-45-6
19992-69-9
205-99-2
20830-81-3
2126-70-7
21739-91-3
21794-01-4
21884-44-6
22089-22-1
2275-81-2
23214-92-8
23255-93-8
23527-02-5
2425-06-1
24280-93-1
24632-47-1
25013-16-5
2507-27-9
2541-69-7
25535-16-4
2581-34-2
286-20-4
298-81-7
302-48-7
302-70-5
303-34-4
305-03-3
3105-97-3
315-22-0
33447-90-4
3347-91-5
33868-17-6
3590-07-6
366-70-1
3688-53-7
37132-72-3
3778-73-2
3817-11-6
3902-71-4
39156-41-7
3930-19-6
4213-45-0
4238-92-0
443-48-1
446-86-6
4685-U-7
477-30-5
495-48-7
50-07-7
50-18-0
2,4-dichlorophenyl-
4-nitrophenyl ether
tetrachloroisonaphthonitrile
1-<3-pyridinyl)-3,3-dimethyl-
triazene
benzo(b)fluoranthene
daunomycin
sodium(z)-3-bromo-4-(4-methyoxy-
phenyl)-4-oxo-2-butenoic acid
cytembena
rubratoxin b
(-)-luteoskyrin
trofosfamide
p,p-bis(1-aziridinyl)-n-propyl-
phosphinic amide
adriamycin (doxorubicin)
hycanthone methanesulfonate
thuringiensin a
captafol
mycophenolic acid
nifurprazine
butylated hydroxyanisole
lycurim
7-methylbenz(a)anthracene
propidiun iodide
4-nitro-m-cresol
1,2-epoxycyclohexane
methoxalen (8-methoxypsoralen)
p,p-bis(1-aziridinyl)-n-ethyl-
phosphinic amide
nitrogen mustard oxide
hydrochloride
lasiocarpine
chtorambucil
hycanthone
monocrotatine
meso-dimethylbusulfan
(+/-)-dimethylbusulfan
methylnitrolocyanamide
n,n-bis(2-chloroethyl)
ethylamine hydrochloride
procarbazine
furylfuranride
fotrin
ifosfamide
n-butyl-n-(4-hydroxybutyl)
nitrosamine
trioxalene---4,5',8-trimethyl
psoraIen
2,4-diaminoamisole sulfate
streptonigrin
quinacrine mustard
p,p-bis<1-aziridinyl)-n-butyl-
phosphinic amide
metronidazole
azathioprine
paraquat
demecolcine (cotceroid)
azoxybenzene
mttomycin c
eyeIophosphami de
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
1-3
-------
Appendix I (continued)
CAS.NUMBER
CHEMICAL
SCORE
50-29-3
50-53-1
50-76-0
500-66-3
50355-74-3
50924-49-7
51-18-3
51-75-2
51-79-6
512-56-1
52-24-4
523-50-2
53-19-0
53-96-3
5307-14-2
54-05-7
54-85-3
54-88-6
540-73-8
54350-48-0
545-55-1
54827-17-7
55-18-5
5522-43-0
55-86-7
55-98-1
56-49-5
56-53-1
56-75-7
57-13-6
57-22-7
57-39-6
57-44-3
577-66-2
5774-35-6
5781-91-9
57-97-6
58-40-2
58-89-9
589-41-3
59-05-2
59-87-0
59-89-2
592-31-4
592-62-1
5957-75-5
5977-35-5
60-11-7
61-73-4
614-00-6
615-53-2
62-53-3
p.p'-OOT N/A
chlorpromazine N/A
actinomycin 0 N/A
olivetol N/A
3,3-dimethyl-1-<2,4,6-tri-
chlorophenyDtriazene N/A
bredinin N/A
triethylenemelamine N/A
nitrogen mustard N/A
urethane N/A
trimethyl phosphate N/A
thio-tepa (thiophosphamide) N/A
angelicin N/A
mitotane N/A
2-acetylaminofluorene N/A
2-nitro-p-phenyIenediamine
(c.i. oxidation base 22) N/A
chloroquine N/A
isoniazid N/A
n-methyl-4-(dimethylamino)
azobenzene N/A
1,2-dimethylhydrazine N/A
retinoid N/A
triethylenephosphoramide N/A
S.S'.S.S'-tetramethyl-
benzidine N/A
diethylnitrosamine N/A
1-nitropyrene N/A
nitrogen mustard
hydrochloride N/A
busulfan N/A
3-methylchotanthrene N/A
diethytstilbestrol N/A
chloramphenicol N/A
urea N/A
vincristine N/A
metepa N/A
barbital N/A
8-ethoxycaffeine N/A
p,p-bis(1-aziridinyl)-n-
isopropyl phosphinic amide N/A
o,o-diethyl-2-bis(2-chloroethyl)
aroinoethylphosphonate N/A
7,12-dimethytbenzanthracene N/A
promazine N/A
garoma-lindane N/A
hydroxyurethane N/A
methotrexate N/A
nitrofurazone N/A
n-nitrosonwrpholine N/A
butylurea N/A
methylazoxymethanol acetate N/A
delta(8)-trans-tetrahydro-
cannabinol N/A
3-bis(2-chloroethyl)amino-
4-methylbenzoic acid N/A
4-dimethylafflinoazobenzene N/A
methylene blue N/A
n-methyl-n-nitrosoaniline N/A
methylnitrosourethane N/A
psoraIen N/A
1-4
-------
Appendix I (continued)
CAS. NUMBER
62-75-9
62-55-5
6287-61-2
6369-59-1
64-67-5
64-86-8
65-61-2
6558-78-7
66-81-9
67-20-9
68-76-8
680-31-9
684-93-5
69-05-6
72-54-8
72-55-9
7203-90-9
7227-91-0
7239-21-6
75-07-0
759-73-9
7803-49-8
7803-57-8
789-02-6
79-46-9
8048-52-0
8063-14-7
817-09-4
865-21-4
869-01-2
869-24-9
91-59-8
92-48-8
92-52-4
92-62-6
924-16-3
94-20-2
96-48-0
97-56-3
99-30-9
99-56-9
999-81-5
CHEMICAL
dime thy Ini trosamt ne
thioacetamide
9-8llyt-1,3,7-trimethyl
uric acid
toluene-2,5-diaroine sulfate
(c.i. oxidation base)
diethyl sulfate
colchicine
acridine orange
n-ni trosobuty lurethane
cyclohexamide
nitrofurantoin
triaziquone
hexametapol
1-methyl-1-nitrosourea
quinacrine dihydrochloride
p.p'-OOD
p,p'-OOE
1-(4-chlorophenyl)-3,3-
dimethyltriazene
3,3-dimethyl-1-phenyl-
triazene
1-(4-bromophenyl)-3,3-dimethyl
triazene
acet aldehyde
1 - ethy I - 1 - n i t rosourea
hydroxylamine
hydrazine hydrate
o,p'-OOT
2-nitropropane
acrif lavine
marihuana
trinustine
vinblastine
1 -butyl • 1 -ni t rosourea
n-(2-chloroethyl)-n,n-
diethylamine
2-naphthaleneamine
6-methylcoumarin
biphenyl
prof lavine
dibutylnitrosamine
chlorpropamide
gamna - buty ro I ac t one
o- ami noazoto I uene
(c.i. solvent yellow)
bo t ran
4-nitro-o-phenylenediamine
(2-chloroethyDtrimethyl
ammonium chloride
SCORE
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
"N/A" indicates chemicals that received no score due to lack of sufficient data.
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