DIRECTORY OF INFORMATION RESOURCES RELATED TO
HEALTH, EXPOSURE, AND RISK ASSESSMENT OF AIR TOXICS
                       DRAFT UPDATE
                         Prepared for:

                  U.S. Environmental Protection Agency
                Office of Air Quality Planning and Standards
                    Pollutant Assessment Branch
                  Research Triangle Park, NC 27711
                         Prepared by:

                 Alliance Technologies Corporation, Inc.
                   6320 Quadrangle Drive, Suite 100
                      Chapel Hill, NC  27514
                        Octobers, 1991
                                      ALLIANCE
                                      Technologies Corporation

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  DIRECTORY OF INFORMATION RESOURCES RELATED TO
HEALTH, EXPOSURE, AND RISK ASSESSMENT OF AIR TOXICS
                         DRAFT UPDATE
                            Prepared for:

                   U.S. Environmental Protection Agency
                 Office of Air Quality Planning and Standards
                      Pollutant Assessment Branch
                    Research Triangle Park, NC 27711
                            Prepared by:

                   Alliance Technologies Corporation, Inc.
                     6320 Quadrangle Drive, Suite 100
                         Chapel Hill, NC 27514
                           Octobers, 1991

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DIRECTORY OF INFORMATION RESOURCES RELATED TO HEALTH, EXPOSURE, AND
                     RISK ASSESSMENT OF AIR TOXICS
                                    by
                  Air Risk Information Support Center (Air RISC)
                     U.S. Environmental Protection Agency
                               Sponsored by:

                  Office of Air Quality Planning and Standards
                      Research Triangle Park, NC  27711

                 Office of Health and Environmental Assessment
                      Research Triangle Park, NC  27711
                           Washington, DC  20460
                            Cincinnati, OH  45268

                 Center for Environmental Research Information
                            Cincinnati, OH  45268

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                                        DISCLAIMER

This report has been reviewed by the Office of Air Quality Planning and Standards of the Office of Air and
Radiation, and by the Office of Health and Environmental Assessment and the Center for Environmental
Research Information of the Office of Research and Development and approved for publication.  Approval
does not signify  that the contents necessarily  reflect the views and  policies of the U.S. Environmental
Protection Agency,  nor does  mention of trade names or commercial products constitute endorsement or
recommendation for use.
                                              in

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IV

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                                 TABLE OF CONTENTS
PREFACE  	  xi
SUMMARY OF INFORMATIONAL RESOURCES	  xiii

SECTION I: INFORMATIONAL RESOURCES	  1

EPA INFORMATIONAL RESOURCES - PRIMARY SOURCES	  2

1.     Air Risk Information Support Center (Air RISC)	  2
2.     Control Technology Center (CTC)  	  3
3.     Emergency Planning and Community Right-to-Know Information Hotline	  4
4.     Integrated Risk Information System (IRIS) 	  5
5.     National Air Toxics Information Clearinghouse (NATICH)  	  6
6.     Resource Conservation and Recovery Act (RCRA)/Comprehensive Environmental
      Response, Compensation, and Liability Act (CERCLA) Hotline  	  7
7.     Toxic Chemical Release Inventory Data Base (TRI)	  8
8.     Toxic Substances Control  Act (TSCA) Assistance Information Service	  9

EPA INFORMATIONAL RESOURCES - SECONDARY SOURCES	  10

9.     Asbestos Hotline	  10
10.    Reasonably Available Control  Technology (RACT)/Best  Available  Control Technology
      (BACT)/Lowest Achievable Emission Rate (LAER) Clearinghouse	  10
11.    Chemical Assessment Desk	  11
12.    Fuel and Fuel Additive Registration Program  	  13
13.    Information Referral System (INFOTERRA)	  13
14.    Motor Vehicle Anti-Tampering Program  	  14
15.    Public Information Center  (PIC)	  15
16.    Risk Communication Hotline	  15
17.    Safe Drinking Water Hotline	  15
18.    Asbestos and Small Business Ombudsman's Office	  16
19.    U.S. Environmental Protection Agency - Library Services  	  16

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NON-EPA INFORMATIONAL RESOURCES  	   17

20.    Cancer Information Service (CIS)	   17
21.    Chemical Transportation Emergency Center (CHEMTREC)	   17
22.    National Pesticide Telecommunications Network (NPTN)  	   17
23.    National Response Center (NRC) Support Center and Hotline	   18
24.    Poison Control Centers	   19

SECTION II: EPA OFFICES	   21

OFFICE OF AIR AND RADIATION (OAR)	   23
25.    Office of Atmospheric and Indoor Air Programs (OAIAP)  	   23
      25.1  Acid Rain Division	   23
      25.2  Global Change Division	   24
      25.3  Indoor Air Division 	   24
26.    Office of Air Quality Planning and Standards (OAQPS)	   24
      26.1  Technical Support  Division 	   25
            26.1.1 Monitoring and Reports Branch	  26
            26.1.2 Emission Measurement Branch  	   26
            26.1.3 Source Receptor Analysis Branch   	26
            26.1.4 National Air Data Branch	  27
      26.2  Air Quality Management Division (AQMD)	  27
            26.2.1 Ambient Standards Branch      	  28
      26.3  Emission Standards Division (ESD)	   29
            26.3.1 Chemicals and Petroleum Branch	  29
            26.3.2 Industrial Studies Branch   	   30
            26.3.3 Pollutant Assessment Branch	   30
            26.3.4 Standards Development Branch	   31
27.    Office of Mobile Sources (QMS)  	   31
      27.1  Technical Support  Staff	   32
28.    Office of Radiation Programs (ORP)  	   32
      28.1  Bioeffects Analysis Branch 	   33
      28.2  Environmental Standards Branch	   33
      28.3  Radon Division	   33
                                             vi

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OFFICE OF PESTICIDES AND TOXIC SUBSTANCES (OPTS)	  34
29.    Office of Pesticide Programs (OPP)	  34
      29.1   Health Effects Division (HED) 	  34
            29.1.1 Occupational and Residential Exposure Branch	  34
            29.1.2 Toxicology Branch	  35
30.    Office of Toxic Substances (OTS)  	  36
      30.1   Chemical Control Division (CCD)	  37
      30.2   Existing Chemical Assessment Division (ECAD)  	  37
      30.3   Exposure Evaluation Division (EED)	.-	  38
      30.4   Health and Environmental Review Division (HERD)	  38
      30.5   Information Management Division (IMD)	  39
      30.6   TSCA Assistance Information Service   	  39

OFFICE OF RESEARCH AND DEVELOPMENT (ORD)	  40
31.    Office of Modeling, Monitoring Systems, and Quality Assurance (OMMSQA)	  40
      31.1   Modeling and Monitoring Systems Staff	  40
      31.2   Atmospheric Research and Exposure Assessment Laboratory (AREAL)	  41
32.    Office of Technology Transfer and Regulatory Support (OTTRS)	  42
      32.1   Center for Environmental Research Information (CERI)	  42
33.    Office of Environmental Processes and Effects Research (OEPER) 	  43
34.    Office of Health and Environmental Assessment (OHEA)  	  43
      34.1   Human Health Assessment Group (HHAG)  	  44
      34.2   Exposure Assessment Group (EAG)  	  44
      34.3   Environmental Criteria and Assessment Office-Cincinnati (ECAO-Cin)	  45
      34.4   Environmental Criteria and Assessment Office-Research Triangle Park  	  45
35.    Office of Health Research (OHR)	  46
      35.1   Health Effects Research Laboratory (HERL)	  46
           35.1.1 Genetic Toxicology Division     	47
           35.1.2 Neurotoxicology Division    	•	47
           35.1.3 Research  Support Division  	 48
           35.1.4 Environmental Toxicology Division  	  48
           35.1.5 Developmental Toxicology Division  	  49
           35.1.6 Human Studies Division  	  49
36.    Risk Assessment Forum 	  49
                                            vii

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OFFICE OF SOUD WASTE AND EMERGENCY RESPONSE (OSWER) 	  50
37.   Office of Emergency and Remedial Response (OERR) 	  50
     37.1  Hazardous Site Control Division (HSCD)  	  50
     37.2  Hazardous Site Evaluation Division (HSED) 	  51
     37.3  Emergency Response Division (ERD)	  51
     37.4  Office of Program Management (OPM) 	  51

OFFICE OF THE ADMINISTRATOR	  52
38.   Office of Cooperative Environmental Management	  52

SECTION III: EPA REGIONAL INFORMATIONAL RESOURCES	  53

SECTION IV: KEY REFERENCE MATERIALS  	  57

INDEX	  67

APPENDIX: DATA BASES CONTAINING INFORMATION RELEVANT TO HEALTH,
EXPOSURE, AND RISK ASSESSMENT OF AIR TOXICS 	A-1
                                       viii

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                            FIGURES AND TABLES

FIGURE 1:  EPA ORGANIZATION CHART	22
FIGURE 2:  EPA REGIONAL OFFICES - COVERAGE BY STATE	55

TABLE 1:  EPA REGIONAL OFFICES	54
TABLE 2:  REGIONAL CONTACTS IN FOUR KEY SUBJECT AREAS	56
                                    ix

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                                           PREFACE


Many State and local agencies are developing or implementing programs to control emissions of toxic air

pollutants.  To successfully carry out these programs, in many cases, agency personnel must be familiar

with  a wide range of issues  related to health, exposure, and risk assessment for toxic air pollutants.

Locating appropriate sources of information on these topics,  however, is not always an easy task.  This

directory has been prepared by the U.S. Environmental Protection Agency's  (EPA's) Air Risk Information
Support Center (Air RISC) as a  resource tool for State and local air pollution control agencies and EPA

Regional Offices to identify useful sources of information regarding health, exposure, and risk assessments

for toxic air pollutants.


The Air RISC is operated by EPA's Office of Air Quality Planning and Standards (OAQPS), Office of Health

and Environmental Assessment (OHEA), and Center for Environmental Research Information (CERI).  The

key goal of Air RISC is to provide technical assistance to State and local air pollution control agencies and

EPA Regional Offices in  obtaining,  reviewing,  and  interpreting  health,  exposure, and risk assessment
information for toxic air pollutants. Through Air RISC, State, local, and EPA Regional Office personnel can

request expert guidance and  information  on  health,  exposure, and  risk assessment issues  and

methodologies  related to toxic air pollutants.


This directory is divided into four sections and an appendix:


        •    Section I:  Informational Resources - Various informational sources that are available to State
            and local agencies are described. These resources include support centers, clearinghouses,
            hotlines, and data bases.  Where appropriate,  contacts, addresses, and/or telephone numbers
            are provided.

            This section is divided into three parts.  First, primary EPA  sources of information that can
            respond to a  wide  range  of questions on toxic air pollutants or health, risk, and exposure
            assessments are described. Next, secondary EPA sources of information are presented which,
            though not primarily established to respond to questions on  toxic air pollutants, may provide
            other useful information. Lastly,  non-EPA information sources are described. These resources
            can provide health assessment and emergency response information.  A summary of these
            resources, which  may be removed from this directory and posted, is provided at the end of the
            introduction.

        •    Section II:  Kev EPA Offices - This  section describes the functions of key EPA offices  that
            perform work and/or provide information related to health, risk, and exposure assessments of
            toxic air pollutants.  An address and/or phone number for each office is provided.
                                               XI

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        •    Section III:  EPA Regional Information Resources-Regional Office general information numbers
            and appropriate contacts for air toxics, library services, Superfund, and Resource Conservation
            and Recovery Act (RCRA) program offices are listed for each Region.

        •    Section IV:  Kev Reference Materials - References  concerning health, exposure, and risk
            assessments for toxic and criteria air pollutants are listed. These resources include chemical
            profiles;  occupational  health and safety  documents;  health and  exposure assessment
            documents; and risk assessment references.

        •    Index - Key subject areas are provided to serve as a quick reference to the resources and EPA
            offices listed in Sections I and II.

        •    Appendix:  Kev Data  Bases - Data bases that are useful sources of health, exposure, and risk
            assessment information are  listed  and briefly described in the appendix.  Information on
            accessing these data bases is also included.


This directory is intended as a reference source to be used as a starting point for accessing technical
assistance and information relative to health, exposure, and risk assessments for toxic air pollutants.
                                               xii

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                         SUMMARY OF INFORMATIONAL RESOURCES
1.      Air Risk Information Support Center (Air RISC).   Provides technical  assistance and  information
       relative to health, exposure, and risk assessments for toxic and criteria air pollutants. 919-541 -0888.


2.      Control Technology Center (CTC).   Provides engineering guidance  and support on  emission
       characterization and air pollution control technology.  919-541-0800.

3.      Emergency Planning and Community Right-to-Know Information Hotline.    Answers  questions
       regarding the Emergency Planning and Community Right-to-Know Act (SARA Title III). 1-800-535-
       0202/703-920-9877.

4.      Integrated Risk Information System (IRIS). An on-linedata base containing chemicai-specifictoxicity
       and regulatory information. 513-569-7254.

5.      National Air Toxics Information Clearinghouse (NATICH). Assists in exchange of information about
       air toxics and the development of air toxics programs.  The NATICH data base contains permitting
       data, ambient air monitoring data, and research and methods development information.  919-541-
       0850.

6.      Resource Conservation and Recovery Act  (RCRA)/Comprehensive Environmental
       Response. Compensation, and Liability Act (CERCLA)  Hotline. Explains EPA regulations and policy
       under the RCRA/CERCLA (Superfund) and Underground Storage Tanks (UST) programs.  1-800-
       424-9346/202-260-3000/703-920-9810.

7.      Toxic Chemical Release Inventory Data  Base (TRI). Provides instructions on how to access and use
       the TRI data base.  202-260-8620. See  Regional contacts listed on page 9.

8.      Toxic Substances Control Act (TSCA) Assistance Information Service.  Provides information on
       TSCA regulations. 202-554-1404.

9.      Asbestos Hotline.  Provides technical information concerning asbestos abatement problems. 1-800-
       835-6700/202-554-1404.

10.    Reasonably Available Control TechnologyfRACT)/Best Available Control Technology (BACT)/
       Lowest Achievable Emission Rate (U\ER) Clearinghouse. Assists in exchanging information about
       BACT and LAER determinations as established under the Clean Air Act. 919-541-5432.

11.    Chemical Assessment Desk. Offers technical consultation and information on chemical risk-related
       issues, chemical toxicity, and environmental fate from the OTS  Existing Chemicals Program. 202-
       260-3483. See Regional contacts listed on page 12.

12.    Fuel and  Fuel Additive  Registration Program. Provides information regarding the description and
       registration of fuels and fuel additives.  202-260-8001.

13.    Information Referral System (INFOTERRA).  A  global  information system linking environmental
       decision-makers with scientific and technical data and  expertise. 202-260-5917.
                                             XIII

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14.    Motor Vehicle Anti-Tampering Program.   Provides  information  pertaining  to enforcement  of
       tampering regulations (Clean Air Act), gasoline additives, and emission standards.  202-260-9040.

15.    Public Information Center (PIC).  Answers inquiries from the public  about  EPA  programs and
       activities.  202-260-2080.

16.    Risk Communication Hotline.  Provides information on risk communication, research, skill building,
       implementation, and evaluation. 202-260-5606.

17.    Safe Drinking Water Hotline.  Answers questions about  the  Safe  Drinking Water Act  (and  its
       amendments), and EPA drinking water programs.  1-800-426-4791.

18.    Asbestos and Small Business Ombudsman's Office. Assists small businesses in complying with
       environmental laws  including EPA regulations.  1-800-368-5888/703-557-1938.

19.    U.S. Environmental  Protection Agency - Library Services.   Supports  EPA offices by providing
       information on chemical toxicity and all aspects of air pollution.  919-541-2777.  See Regional
       contacts listed on page .

20.    Cancer Information  Service. Answers general questions about the relationship of indoor air pollution
       and cancer, and the treatment, diagnosis, and  prevention of cancer.  1 -800-4-CANCER.

21.    Chemical Transportation Emergency Center (CHEMTREC).    Provides  assistance to chemical
       shippers, handlers, and emergency responders in problem situations.  1 -800-424-9300.

22.    National Pesticide Telecommunications Network (NPTN).   Provides information about pesticide
       products, poisonings, safety information, and cleanup and disposal  procedures. 1 -800-858-7378.

23.    National Response Center (NRG) Support Center and Hotline.  Responds to phone calls regarding
       accidental releases of oil and hazardous substances; calls to NRC satisfy the reporting requirements
       of Federal regulations such as Superfund.  1 -800-424-8802/202-267-2675.

24.    Poison Control Centers. Answer specific questions about situations involving poisons. See contacts
       listed on page 19.
                                              xiv

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                                          SECTION I
                                INFORMATIONAL RESOURCES

Section  I describes 19 primary and secondary sources of information  (e.g., clearinghouses, hotlines)
sponsored by EPA as well as useful information services available through other organizations.  The EPA
primary information sources are easily accessed by State and local agencies and can provide information
on a wide range of topics related to toxic air pollutants or health, exposure, and risk assessments.  EPA
secondary information sources do not deal specifically with air toxics issues but may be useful for obtaining
information on related topics.  For some of these sources (e.g., Chemical Assessment Desk, see page 11),
State and local agencies should work with the appropriate EPA Regional  Office to receive the necessary
information.  Five non-EPA information services are also described in Section I. These sources may provide
useful information  on toxic air pollutants, emergency response activities, and other related topics.

A summary of all  these information sources is provided at the end of the  Introduction (page xiii).  This
summary may be removed from the directory and posted for convenient reference. Also, each informational
resource is numbered; these numbers are used in the directory's index to  direct readers to resources that
provide information on specific subject areas.

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EPA INFORMATIONAL RESOURCES - PRIMARY SOURCES

1.     Air Risk Information Support Center (Air RISC)

       Office of Air Quality Planning and Standards (MD-13)
       U.S. EPA
       Research Triangle Park, NC 27711

       Office of Health and Environmental Assessment (RD-689)
       U.S. EPA
       Washington, DC  20460

       Environmental Criteria and Assessment Office (MD-52)
       U.S. EPA
       Research Triangle Park, NC 27711
       and
       Cincinnati, OH  45268

       Center for Environmental Research Information
       U.S. EPA
       26 W. Martin Luther King Street
       Cincinnati, OH  45268

       Air RISC Hotline
       919-541-0888
       FTS 629-0888
       Monday through Thursday, 8:00 a.m. to 5:00 p.m., EST
       Friday, 8:00 a.m.  to 4:00 p.m., EST

Many State and local agencies are developing or have implemented programs to control toxic air pollutants.

As part of many of these programs, health risks resulting from exposure to toxic air pollutants are assessed.

Agencies are faced with the evaluation of many pollutants and source types with a wide array of methods

available for evaluating public exposures and risks. Information may be difficult to find quickly and may be

ambiguous or difficult to interpret.


The Air Risk Information Support Center (Air RISC) provides, in a timely fashion, technical assistance and

information relative to health,  exposure, and risk assessments for toxic air pollutants.  The Air R!SC is

operated  by EPA's Office of Air Quality Planning and  Standards (OAQPS),  Office  of Health  and

Environmental Assessment (OHEA), and Center for Environmental Research  Information (CERI).


The EPA has worked with the State and Territorial Air  Pollution Program Administrators  (STAPPA), the

Association of Local Air Pollution Control Officials (ALAPCO), and EPA Regional Offices in the design and

development of the Air RISC to ensure that the Center will be useful for State and local agencies as well as

EPA Regional Offices. The primary goal of  Air RISC is to provide health, exposure, and risk  information for

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State and local air pollution control agencies and EPA Regional Offices and, where  needed, assist in

reviewing and interpreting that data.  The Air RISC provides three levels of assistance:


       •   Hotline.  The Air RISC Hotline puts agencies  and offices in direct contact with a variety of
           experts.  The Hotline is designed to provide an initial, quick response based on available data
           and expertise.

       •   Detailed technical assistance. When more in-depth evaluations or information are needed than
           appropriate for a quick response, such requests may be phoned in to the Hotline. The requests
           will be considered according to available time and resources.  Examples of detailed technical
           assistance include review and interpretation of lexicological information, and review of site-
           specific exposure assessments, risk assessments, or both.

       •   General technical guidance.  The Air RISC also provides general guidance on health, exposure,
           and risk assessment issues that have broad national interest, such as guidance documents dis-
           cussing methodologies available for evaluating multi-pollutant exposures or risk assessment
           techniques.  General technical  guidance may  be provided in  the form  of documents,
           videotapes, or workshops.


The Air RISC also provides a feedback mechanism for State and  local air agencies to identify to EPA the

technical support  needs of their agencies in the areas of health,  exposure, and risk assessment.  Policy
guidance and risk management advice, however, are outside the  scope of the Air RISC.


2.      Control Technology Center (CTQ

       Office of Air Quality Planning and Standards
       U.S. EPA
       Research  Triangle Park,  NC  27711

       Air and Energy Engineering Research Laboratory
       U.S. EPA
       Research  Triangle Park,  NC  27711

       Center for Environmental Research Information
       U.S. EPA
       Cincinnati, OH 45268

       Control Technology Center Hotline
       919-541-0800
       FTS 629-0800
       Monday through Friday, 7:30 a.m. to 5:00  p.m., EST
       (Telephone answering machine operates after 5:00 p.m., EST)

       Control Technology Center Bulletin Board
       919-541-5742 (1200/2400 baud)
       919-541-1447 (9600 baud)

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The Control Technology Center (CTC) primarily supports State and local agencies and EPA Regional Offices

in implementing air pollution programs for both toxic and criteria air pollutants by providing engineering

guidance and support on air pollution control technology. The CTC can provide three levels of assistance:


       •   Hotline.  The Hotline provides  initial, rapid responses to questions and problems based on
           available information and expertise.

       •   Engineering assistance.  More in-depth engineering  assistance than what the Hotline can
           provide, or, if necessary, on-site support, is also available.  The CTC  can assist in evaluation
           of source emissions;  identification of control  alternatives; development  of control  costs;
           identification  of  pollution  impacts of  control technologies; source testing  methods  and
           problems; advice on permit conditions; and expert testimony in support of State or local
           regulatory actions.

       •   Technical guidance.   The  CTC also  provides formal  control technology guidance  and
           information transfer through control technology documents, personal  computer software, and
           seminars and workshops.


The CTC also provides information through a quarterly newsletter and an electronic bulletin board:


       •   CTC News.  The CTC publishes a quarterly newsletter to provide clients with information on
           CTC activities, technical issues, and the RACT/BACT/LAER Clearinghouse.

       •   CTC Bulletin Board. The CTC provides a  Bulletin Board Service on the OAQPS Technology
           Transfer Network.  Users may order CTC documents, leave Hotline requests, view document
           summaries, leave project suggestions, and download  software.  The only cost involved is the
           cost of the phone call.


3.      Emergency Planning and Community Right-to-Know Information Hotline

       SARA Title III Hotline
       Office of Solid Waste and Emergency Response (OS-120)
       U.S. EPA
       401 M Street, S.W.
       Washington, DC 20460
       1-800-535-0202
       703-920-9877
       Monday through Friday, 8:30 a.m. to 7:30 p.m., EST

The Superfund Amendments and Reauthorization Act (SARA) Title III Hotline is operated under the guidance

of the Office of Solid Waste and Emergency Response  (OSWER).  The Hotline can answer questions from

manufacturers, government agencies,  and the general public  regarding the Emergency Planning  and

Community Right-to-Know Act (SARA Title III).  SARA Title III establishes requirements for Federal, State,

and local governments and industry regarding emergency planning and community right-to-know reporting

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on hazardous and toxic chemicals.  There are four major parts to Title III: emergency response planning
(Sections 301 to 303); emergency notification (Section 304); community right-to-know (Sections 311, 312);
and toxic chemical release reporting (Section 313). Hotline specialists can answer questions and requests
concerning all four sections of Title III.

4.      Integrated Risk Information System (IRIS)
       IRIS User Support
       Environmental Criteria and Assessment Office
       U.S. EPA
       26 W. Martin Luther King Drive
       Cincinnati, OH  45268
       513-569-7254
       FTS 684-7254
The Integrated Risk Information System (IRIS), administered by EPA's Office of Health and Environmental
Assessment, is an electronic data base containing health risk and EPA regulatory information on specific
chemicals.  IRIS, which is updated monthly, is the Agency's primary vehicle for communication of chronic
health hazard information representing  EPA consensus positions following comprehensive review by intra-
Agency work groups. It is a useful information resource tool that points the user to the underlying human
and/or animal data used to suport the  Agency's  opinion

The core of the system is a collection of computer files that contain hazard identification and dose-response
risk information for approximately  500  chemicals.  An IRIS chemical file contains up to six types  of risk
related information:
           Oral Reference Doses
           Inhalation Reference Doses
           Risk Assessment for Carcinogens
           Drinking Water Health Advisories
           EPA Regulatory Action Summaries
           Supplementary Data
Combined with specific exposure information, the data in IRIS can be used for characterization of the public
health risks of a given situation, which can then serve as  input for a health  risk management decision
designed to protect public health.

IRIS was developed for EPA staff in response to a growing need for consistent  Agency risk information on
chemical substances for use in decision making and regulatory activities. Although IRIS is designed for EPA

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staff, it is also accessible to the public. State, local, and international communities via several different
methods.  For more information on IRIS and access methods, contact IRIS User Support at 513-569-7254
(FTS 684-7254).

5.       National Air Toxics Information Clearinghouse (NATICH)
        National Air Toxics Information Clearinghouse
        Pollutant Assessment Branch
        Office of Air Quality Planning and Standards (MD-13)
        U.S. EPA
        Research Triangle Park, NC 27711
        919-541-0850
        FTS 629-0850
        Monday through Friday, 7:30 a.m. to 5:00 p.m., EST
The National Air Toxics Information Clearinghouse (NATICH) assists Federal, State, and local agencies in
exchanging  information about air  toxics and the development of air toxics  programs.   NATICH was
established in 1983 by the EPA's Office of Air Quality Planning and Standards (OAQPS) in close coordination
with the State and Territorial Air Pollution Program Administrators (STAPPA) and the Association of Local
Air Pollution Control Officials (ALAPCO). It is administered by the Pollutant Assessment Branch of EPA's
OAQPS.

NATICH information is distributed in five ways:

        •    bimonthly newsletters containing information on Federal, State, and local air toxics programs
            and activities,  research, agency case histories, etc.,*
        •    special reports on specific air toxics issues,*
        •    computerized  data base, NATICH, available at a cost of about $10-$15 per on-line hour of work,
        •    hardcopy reports of data contained in the data base issued on a regular schedule, and
        •    response to requests for specific information.*

The core of NATICH is the NATICH data base which contains all of the information collected from Federal,
State and local agencies.   This information  is generally organized according  to agency, pollutant, and
emission source. State and local agency information includes regulatory program descriptions and contacts;
permitting data; acceptable ambient concentrations; ambient air monitoring information; source test data;
    'Available at no charge to government agencies.
                                                6

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emissions inventory data; research and methods development information; and bibliographic and ongoing
project citations.

Selected  preliminary State and local risk assessment results related  to air toxics are also included in
NATICH.  Research information is presented in two categories: (1) descriptions of ongoing research and
regulatory development projects; and (2) bibliographic citations/abstracts for published documents.

The NATICH data base resides on EPA's IBM mainframe computer and can be accessed using an agency
microcomputer or minicomputer, a modem, and a VT 100 ANSI full  screen emulator package. The data
base is menu-driven; that is, the user can ask questions of the data  base and receive answers via the
computer terminal.  State and local personnel may also enter and edit data in the Clearinghouse for their
agencies.

To obtain on-line access to the NATICH data base, State and local agencies should contact the appropriate
EPA Regional air toxics contact listed on page 53 of this report or the NATICH staff at 919-541-0850,  FTS
629-0850. To obtain copies of NATICH reports or to be placed on the mailing list for future publications,
contact the NATICH staff at the number listed above.

6.      Resource Conservation and Recovery Act (RCRA)/Comprehensive  Environmental
       Response. Compensation, and Liability Act (CERCLA) Hotline
       RCRA/CERCLA Hotline
       c/o Geo/Resource Consultants, Inc.
       401 M Street, S.W.
       Washington, DC  20460
       1-800-424-9346; 202-260-3000; or 703-920-9810 (DC Metro area)
       Monday through Friday, 8:30 a.m. to 7:30 p.m., EST (except Federal holidays)
The  Resource Conservation and Recovery Act  (RCRA)/  Comprehensive  Environmental  Response
Compensation and Liability Act (CERCLA) Hotline has been in operation since 1980.  It is operated under
the guidance of the EPA's Office of Solid Waste and Emergency Response. The primary function of the
RCRA/CERCLA Hotline is to assist the public and regulated community in understanding EPA regulations
and policy under the RCRA/CERCLA (Superfund) and Underground Storage Tank (UST) programs. Hotline
specialists answer regulatory and technical questions and can respond to requests for documents on
virtually all aspects of  the RCRA, CERCLA, and UST programs.  The RCRA/CERCLA Hotline provides
information to Federal, State,  and local governments; regulated communities; people involved in managing
and cleaning up hazardous waste; and the general public.

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7.      Toxic Chemical Release Inventory Data Base fTRI)
       U.S. EPA
       Office of Toxic Substances/Information Management Division (TS-793)
       401 M Street, S.W.
       Washington, DC 20460
       202-260-8620
       FTS 260-8620
Title III, Section 313 of the Superfund Amendments and Reauthorization Act (SARA) of 1986, also known as
the Emergency Planning and Community Right-to-Know law, requires the EPA to establish a toxic release
inventory and to make the toxics emissions data available to the public through telecommunications or other
means.   The National Toxic Chemical Release Inventory (TRI) data base, which became available on
September 1, 1988, was established by EPA to provide EPA Headquarters,  Regions, and States with the
information submitted from facilities on the Form R. At that time, user accounts were established for each
of the EPA Regions and timeshare dollars were made available to permit the Regions and States to access
the TRI data.

The Toxic Chemical Release Inventory System (TRIS) is the computer system and data base designed and
maintained by the EPA to track and store annual estimated releases of toxic chemicals into the environment.
TRIS serves EPA as a management tool to facilitate the  collection, organization, and dissemination of TRI
data from industries regulated under SARA, Section 313.  TRIS contains information about the release of
over 300 different toxic chemicals or chemical compounds.  This information includes reporting facility
identification, chemical identification, parent company information, activity/use data, amount of chemical
released,  medium  released to  (air, water, land,  underground), chemical transfer location,  and waste
treatment and  minimization information. TRI information can be submitted to EPA on paper or magnetic
media.

Persons in EPA  Regional Offices or States who desire  access to the TRI data base should contact the
Regional TRI Account Manager listed on the following page for a User ID and instructions on how to access
the data base. For other information on access to the TRI data base call TRIS User Support at (202)  260-
9419; (FTS) 260-9419.   For other  information about the TRI data, call the Emergency Planning  and
Community Right-to-Know Information Hotline at 1-800-535-0202.

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                  TOXIC CHEMICAL RELEASE INVENTORY SYSTEM (THIS)
                                 ACCOUNT MANAGERS
Headquarters
Region 1
Region II
Region III
Region IV
Region V
Region VI
Region VII
Region VIII
Region IX
Region X
Washington, DC
Boston
New York
Philadelphia
Atlanta
Chicago
Dallas
Kansas City
Denver
San Francisco
Seattle
Carolyn Thornton
Michael MacDougall
Robert Messina
Kim Woodall
Jesse Dooley
Sandra Darden
David White
Dale Parke
Dianne Groh
Jason Look
Gus Parlier
202-260-8620
FTS 260-8620
617-565-3377
FTS 835-3377
913-236-2806
FTS 264-9850
215-597-9358
FTS 597-9358
404-347-2316
FTS 257-2316
312-353-0623
FTS 353-1770
214-655-6540
FTS 255-6540
913-236-2827
FTS 757-2827
303-293-1730
FTS 330-1730
415-974-7733
FTS 484-1804
206-442-2988
FTS 399-2988
8.      Toxic Substances Control Act (TSCA) Assistance Information Service

       TSCA Assistance Information Service
       Office of Toxic Substances (TS-799)
       U.S. EPA
       401 M Street, S.W.
       Washington, DC 20460
       202-554-1404
       Monday through Friday, 8:30 a.m. to 5:00 p.m., EST

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The Toxic Substances Control Act (TSCA) Assistance Information Service is administered by the Office of

Toxic Substances.  It provides information on TSCA regulations to the chemical industry, labor and trade

organizations, environmental groups, and the general public. The TSCA Assistance Information Service can

direct inquiries to the appropriate EPA personnel and handle requests for certain publications related to

management of toxic substances.


EPA INFORMATIONAL RESOURCES - SECONDARY SOURCES

9.     Asbestos Hotline

       Office of Toxic Substances (TS-799)
       U.S. EPA
       401  M Street, S.W.
       Washington, DC 20460
       1-800-835-6700 or 202-554-1404
       Monday through Friday, 8:30 a.m. to 5:00 p.m., EST (off peak calling hours are before 9:00 a.m. and
       after 4:00 p.m.)

The  Asbestos Hotline provides  technical information concerning asbestos abatement  problems.  The

Hotline's information specialists answer questions from the general public, government agencies, and the

regulated industry.  The Hotline receives many inquiries from both private and public school administrators
about regulations concerning asbestos in schools, compliance with regulations, and funding sources for

asbestos removal or encapsulation.


10.    Reasonably  Available  Control  Technology  (RACTVBest  Available   Control  Technology
       (BACT) /Lowest Achievable Emission Rate (LAER) Clearinghouse

       Emission Standards Division
       Office of Air Quality Planning and Standards (MD-13)
       U.S. EPA
       Research Triangle Park,  NC 27711
       919-541-2736
       FTS 629-2736
       Monday through Friday,  8:00 a.m. to 4:30 p.m., EST



The  RACT/BACT/LAER Clearinghouse assists Federal, State, and local agencies and  others involved in

preparing or reviewing permit applications for affected sources in exchanging information about RACT,

BACT, and LAER determinations as established under the Clean Air Act. This Clearinghouse was established

in 1979 and is  a cooperative effort between EPA and the State and Territorial  Air Pollution  Program

Administrators (STAPPA) and the Association of Local Air Pollution Control Organizations (ALAPCO).
                                              10

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RACT/BACT/LAER information is distributed in five ways:

       •   quarterly Control Technology Center (CTC) newsletters containing information on the status and
           use of the Clearinghouse as well as "helpful hints,"
       •   annual reports on RACT/BACT/LAER determinations,
       •   a computerized data base, the RACT/BACT/LAER Information System (BUS),
       •   customized computer printouts of data contained in the data base, issued on an as needed
           basis, and
       •   responses to State and local agency requests for specific information.

The core of the Clearinghouse is the RACT/BACT/LAER Information System (BUS). This data base contains
information on RACT,  BACT, and LAER determinations including source (plant) descriptions  (location,
product(s) and production rates),  permitting agency, permitted units within the plant, air pollutant limits,
conditions of plant operations, and a contact name and telephone number to obtain more information.

The BLIS resides on EPA's IBM mainframe computer and can be accessed using a personal  computer,
modem, and  communications software.  The user can  request lists of information based on specific
characteristics, for example, of all  BACT determinations for sulfuric acid  plants.  The user-friendly system
which is in place requires no knowledge of data base commands. There is no user's manual; however, there
are numerous help screens available throughout the system.  The user may search the data base on any
3 of 10 available criteria including plant name,  source category,  process name, and pollutant  name.  A
customized printout may then be generated and either sent to a remote or the main printer at the National
Computer Center or may be downloaded directly to the user's computer.

11.    Chemical Assessment Desk
       Office of Toxic Substances (TS-778)
       U.S. EPA
       401 M  Street, S.W.
       Washington, DC 20460
       202-260-3483
       FTS 260-3483
The Chemical Assessment Desk (CAD) is a designated contact in the EPA Office of Toxic Substances (OTS)
for chemical risk-related questions. The CAD can provide the most assistance on chemicals which have
been evaluated in  the OTS Existing Chemicals Program, but estimates of toxicity  and environmental
persistence based on structure-activity relationships can sometimes be provided as well.  The CAD also
                                              11

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serves as a mechanism for nominating chemicals for screening in the Existing Chemicals Program, which
feeds into the RM-1 process.  The CAD's primary audience is EPA Regional and other program offices, but
it is available to other Federal and State agencies. States, however, are asked to submit questions through
designated Regional contacts in the Pesticides and Toxics Branch.  For State and local agencies, the CAD
operates through the following Regional coordinators:
                               CHEMICAL ASSESSMENT DESK
                                 REGIONAL COORDINATORS
Headquarters Washington, DC
Region I Boston

Region II New York

Region III Philadelphia

Region IV Atlanta
Region V Chicago

Region VI Dallas
Region VII Kansas City
Terry O'Bryan
Suzanne Parent
Greg Roscoe
Diane Buxbaum
Dan Kraft
John Ruggero
Ed Cohen
John Stockwell
Alfreda Freeman
Milt Clark
Bob Allen
Warren Layne
Louis Robertson
Bob Jackson
Jim Hirtz
202-260-3483
FTS 260-3483
617-565-3704
FTS 835-3704
617-565-3744
FTS 835-3744
201-321-6893
FTS 340-6893
201-321-6669
FTS 340-6669
215-597-9937
FTS 597-9937
215-597-7668
FTS 597-7668
404-347-1033
FTS 257-1033
312-886-3388
FTS 886-3388
312-353-5871
FTS 353-5871
214-655-7244
FTS 255-7244
913-551-7020
FTS 276-7020
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Region VIII Denver

Region IX San Francisco
Region X Seattle

Paul Grimm
Robert Harding
Greg Czajkowski
Gil Haselberger
Dana Davoli
303-393-0981
FTS 330-0981
303-393-1158
FTS 330-1 158
415-744-1116
FTS 484-1 116
206-442-1094
FTS 399-1094
206-553-2135
FTS 399-2135
12.     Fuel and Fuel Additive Registration Program

       Office of Fuel and Fuel Additive Registration (EN-397F)
       U.S. EPA
       401 M Street, S.W.
       Washington, DC  20460
       202-260-8001
       FTS 260-8001
       Monday through  Friday, 7:00 a.m. to 5:00 p.m., EST

The Fuel and Fuel Additive Registration Program is administered by the Field Operation and Support Division

of the Office of Mobile Services.  The program can respond to questions from governmental agencies and
industries regarding the description and registration of fuels and fuel additives.  Names and addresses of

fuel and/or fuel additive manufacturers are also available, upon request.


13.     Information Referral System (INFOTERRA)

       INFOTERRA/USA National Focal Point (PM-211A)
       U.S. EPA
       401 M Street, S.W.
       Washington, DC  20460
       202-260-5917
       FTS 260-5917

INFOTERRA was created by  the United  Nations Environment Programme (UNEP) following the United

Nations Conference on the Human Environment held in Stockholm, Sweden in June 1972. The INFOTERRA

network consists of 138 participating countries, each with a National Focal Point (NFP), under the direction

of the INFOTERRA Programme Activity Center (PAC) in Nairobi, Kenya.
                                             13

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In 1975, the EPA was selected to serve as the U.S. NFP for the INFOTERRA network.  At present, the staff
of the NFP is located in the library of the EPA Headquarters. Resources at the NFP include a small research
collection, a number of periodicals, a subject-specified vertical file, and country and organizational files. All
materials deal with international environmental issues.

The staff at the NFP respond to information requests on a variety of international environmental topics.
Services include the provision of documents, bibliographies, referrals, and substantive research, depending
on the nature of the request.

A major information source of the INFOTERRA network is the International Directory of Sources.  Each
participating NFP is required to identify and register sources of environmental information in their country.
These sources are published in the Directory, a multi-volume set. All information in the Directory is being
updated and a new version of the publication is expected in the summer of 1992.  The same information
which is available in the Directory is also available at the U.S.  NFP in the form of a PC-based data base.

14.      Motor Vehicle Anti-Tampering Program
        Office of Mobile Sources (EN-397F)
        U.S. EPA
        401 M Street,  S.W.
        Washington, DC 20460
        202-260-9040
        FTS 382-4414
        Monday through Friday, 8:30 a.m. to 4:30 p.m., EST
The Motor Vehicle Anti-Tampering Program  is administered  by the Field Operations and Support Division
of the Office of Mobile  Sources.  The program provides the public (especially gas station and garage
owners, and the oil and  gas industry) with information pertaining to enforcement of tampering regulations
(developed under Section 203 of the Clean Air Act) in the form of pamphlets and  public documents, as well
as information over the  phone. The following activities are conducted under the auspices of  the  Motor
Vehicle Anti-Tampering Program:

        •   audits of oil companies for lead levels in gasoline
        •   inspections of gas stations and  garages  regarding compliance with tampering regulations

Staff can answer questions concerning regulations, gasoline additives and emissions standards and can also
respond to catalytic converter warranty inquiries.  Coordination of State and local inspection  programs,
recently augmented with anti-tampering inspections, is now handled out of the Emission Control Technology

                                               14

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Division (ECTD) of the Office of Air and Radiation in Ann Arbor, Michigan.   ECTD staff can be contacted
at 313-668-4471 (FTS 374-8471).


15.      Public Information Center (PIQ

        Public Information Center (PM-211B)
        U.S. EPA
        401 M Street, S.W.
        Washington, DC 20460
        202-260-2080
        FTS 260-2080
        Monday through Friday, 8:00 a.m. to 5:30 p.m., EST

The Public Information Center (PIC) answers inquiries from the public about EPA programs and activities.
PIC also offers a variety of nontechnical information materials. This public service is operated by the Office

of Information Resource Management.


16.      Risk Communication Hotline

        Office of Policy, Planning, and Evaluation
        U.S. EPA
        401  M Street, S.W.
        Washington, DC 20460
        202-260-5606
        Monday through Friday, 8:30 a.m. to 4:30 p.m., EST

The Risk Communication Hotline serves EPA Regions and program offices.  It is an up-to-date resource for
information on risk communication, research, skill building, implementation, and evaluation.  The primary

purpose of this hotline is to provide support to EPA Regional Offices and Headquarters; however, the Hotline

staff will provide assistance to State and local agencies as time and resources permit.  State and local

agencies should first contact their Regional Offices with risk communication questions and concerns. The

Risk Communication Hotline was established in 1987 and is operated under the  Office of Policy, Planning,

and Evaluation.


17.      Safe Drinking Water Hotline

        Safe Drinking Water Hotline
        c/o Geo/Resource  Consultants, Inc.
        1555 Wilson Blvd., Suite 500
        Arlington, VA  22209
        1-800-426-4791
        Monday through Friday, 8:30 a.m. to 5:00 p.m., EST
                                               15

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The Safe Drinking Water Hotline, established in 1987, answers questions regarding the Safe Drinking Water
Act of 1974 (SDWA), the SDWA Amendments of 1986, and EPA drinking water programs (including public
water supply). The Hotline is targeted at a broad audience ranging from regulatory agencies to the general
public.  In addition to responding to questions on regulations, the Hotline can provide a  list of Office of
Drinking Water publications (available through the National Technical Information Service for a fee) and
copies of related Federal Register notices.

18.     Asbestos and Small Business Ombudsman's Office
        U.S. EPA
        401 M Street, S.W.
        Washington, DC  20460
        1-800-368-5888; 703-557-1938
        Monday through Friday, 8:00 a.m. to 4:30 p.m., EST
        (Note:  During the  day, if the staff is occupied, an answering machine will allow  you to leave a
        message.  Calls will be returned as soon as possible.)
This Office assists small businesses in complying with environmental laws including EPA regulations. The
Office acts as a liaison with Agency program offices, and investigates questions regarding EPA requirements.
The Office also ensures that EPA considers small  business issues during its normal regulatory activities.

19.     U.S. Environmental Protection Agency - Library Services
        Library Services Office (MD-35)
        U.S. EPA
        Research Triangle Park, NC 27711
        919-541-2777
        FTS 629-2777
        Monday through Friday, 8:30 a.m. to 4:30 p.m., EST
Twenty-eight  (28) network libraries located in EPA Headquarters and all Regional  Offices and laboratories
support the Agency and can provide information to State and local air pollution control agencies.  Contacts
for the EPA Regional libraries are listed in Section III on page 58.

The Research Triangle Park (RTP)  Library provides support to EPA offices in the  RTP area, including the
Office of Air  Quality  Planning and Standards (OAQPS),  the Environmental  Research  Center,  and the
Environmental Criteria and Assessment Office. Collection concentration is on chemical toxicity, all aspects
of air pollution, as well as the basic  sciences, with some coverage of business and economics. The
collection's historical coverage of air pollution is particularly strong.
                                               16

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The RTP Library operates an Air Information Center (AIC) for the OAQPS. This Center handles requests for
air pollution information and documents.  The AIC provides free literature searches for State and local air
pollution agencies and environmental groups.
NON-EPA INFORMATIONAL RESOURCES
20.    Cancer Information Service (CIS)
       The Cancer Information Service
       1-800-4-CANCER (1-800-422-6237)
       Monday through Friday, 9:00 a.m. to 10:00 p.m.
This Hotline is a service of the National Cancer Institute (NCI).  All phone calls are automatically routed to
the nearest Regional CIS office. A national office in Maryland  answers calls after normal business hours
(4:30 p.m. to 10:00 p.m. local time) and on Saturdays. This Hotline can answer general questions about
the relationship of indoor air pollution and cancer; however, more specific questions about air toxics are
referred to other agencies (e.g., EPA, NIOSH).   Callers  can  also receive information about treatment,
diagnosis, and prevention of cancer from  this Hotline, as well as literature, listings of  local resources
(including home health care, hospitals, and support groups), smoking cessation counseling, and information
on clinical trials.

21.    Chemical Transportation Emergency Center (CHEMTREC)
       1-800-424-9300
       24 hours a day, 365 days a year
The Chemical Transportation Emergency Center (CHEMTREC)  is operated by the Chemical Manufacturers
Association (CMA).  It provides advice and assistance to chemical shippers,  handlers, and emergency
responders in problem situations.  The CHEMTREC maintains files on over 250,000 proprietary chemicals.
During emergencies, CHEMTREC can provide information regarding the effects of most chemicals on people
and the environment and can suggest methods for treatment, containment, and control of an incident. The
CHEMTREC also maintains a directory of experts and industry teams that can assist in an emergency.

22.    National Pesticide Telecommunications Network (NPTN)
       Texas Tech University
       Thompson Hall, Room S-129
       Lubbock, Texas 79430
       1-800-858-7378  (858-P-E-S-T)
       24 hours a day, 365 days a year
                                             17

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The National Pesticides Telecommunications Network (NPTN) Hotline provides information about pesticides
to the medical, veterinary,  and professional communities.   The NPTN  also  serves  the public as  a
clearinghouse for information on pesticides.  This includes providing impartial  information on pesticide
products, recognition and management of pesticide poisonings, toxicology and symptomatic reviews, safety
information, and cleanup and disposal  procedures.  Referrals for laboratory analyses, investigation of
pesticide incidents, and  emergency treatment are also provided.  The Hotline is  staffed by pesticide
specialists with agricultural, environmental, and public health backgrounds at Texas Tech University's Health
Sciences Center School of Medicine. These individuals are also prepared to deal with emergency situations
with  respect to pesticide spills or exposure.

23.     National Response Center (NRG) Support Center and Hotline
        U.S. Coast Guard Headquarters
        Washington, DC  20593-0001
        1-800-424-8802; 202-267-2675
        24 hours a day, 365 days a  year
The National  Response Center (NRC) is  a report processing and coordination center that responds to all
kinds of accidental releases of oil and hazardous substances. The NRC was established in 1974 and  is
staffed by the U.S. Coast Guard. The following incidents may be reported to the NRC's Hotline:

        •   oil spills,
        •   hazardous chemical releases,
        •   pipeline accidents,
        •   transportation accidents involving hazardous materials or oil,
        •   releases of radioactive material, and
        ğ   releases of etiological or hazardous biological material.

A telephone call to the NRC regarding any of the above incidents satisfies the reporting requirements of
Superfund, Federal Water Pollution Control Act, and Department of Transportation regulations.

The NRC also maintains several data bases, including the Oil and Hazardous Materials Technical Assistance
Data System (OHM-TADS) which contains chemical, biological, and lexicological information on more than
1,300 substances.
                                               18

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24.     Poison Control Centers
       24 hours a day, 7 days a week

These centers answer specific questions about situations involving  poisons.  While most calls received
involve questions regarding children, a significant number of calls involve adults exposed to some form of
toxic substance.  These Centers provide medical treatment guidance and can answer general questions
about air toxics, including paint fumes and pesticides. Regional poison control centers service many areas
throughout the United States.
Alabama Poison Center
205-345-0600
800-462-0800 (AL only)
Hennepin Regional Poison Center (Minnesota)
612-347-3144
612-347-3141
Arizona Poison Control System
602-626-7899
602-626-6016 (Tucson)
602-253-3334 (Phoenix)
800-362-0101 (AZ only)
Intermountain Regional Poison Control
Center (UT)
801-581-7504
801-581-2151
Blodgett Regional Poison Center (Ml)
616-774-7854
800-632-2727 (616 area code only)
Cardinal Glennon Children's Hospital
Regional Poison  Center (MO)
314-772-8300
314-772-5200 (Emergency)
Kentucky  Regional  Poison Center  of Kosair
Children's Hospital
502-589-8222
800-722-5725 (KY only) (TDD)

Long Island Regional Poison Control Center
516-542-2323
Central Ohio Poison Center
614-461-2012
614-228-1323
800-682-7625 (OH only)
Los Angeles County Medical Association
Regional Poison Control Center
213-484-5151
800-777-6476 (CA only)
Duke University Poison Control Center
800-672-1697 (NC only)
Georgia Poison Control Center
404-589-4400
404-616-4400
800-282-5846 (GA only)
Maryland Poison Center
301-528-7701
301-528-7702
800-492-2414 (MD only)

Massachusetts Poison Control System
617-735-6607
617-232-2120800-682-9211  (MA only)
                                              19

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Michigan Regional Poison Control Center
313-745-5329
313-745-5711 (Emergency)
San Francisco Bay Area Regional Poison Control
Center
415-476-6600
Mid-Plains Poison Center (NE)
402-390-5555
800-955-9119
Southwest Ohio Regional Poison Control System
513-558-5111
800-872-5111
National Capital Poison Center
301-528-7701
800-492-2414
Tampa Bay Regional Poison Control Center
813-253-4444
800-282-3171
New Jersey Poison Information and Education
System
201-926-7443
800-962-1253 (NJ only)
New Mexico Poison and Drug
Information Center
505-277-4261
505-843-2551
800-432-6866 (NM only)
Texas State Poison Center
409-772-3332
409-765-1420
713-654-1701 (Houston)
800-392-8548 (TX only)

West Virginia Poison Center
304-347-1212
304-348-4211
800-642-3625 (WV only)
New York City Poison Control Center
212-764-7667 (201-POI-SONS)
Pittsburgh Poison Center
412-681-6669
Rhode Island Poison Center
401-277-5906
401-277-5727
Rocky Mountain Poison Center (Colorado)
303-893-7774
303-629-1123
800-332-3073 (CO only)
800-525-5042 (MT only)
800-442-2702 (WY only)
San Diego Regional Poison Center
619-543-6000
800-876-4766
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                                           SECTION II
                                          EPA OFFICES

Section II describes key EPA offices involved in some aspect of health, exposure, and/or risk assessments
for  toxic air pollutants.  The offices listed  have  been  selected as  having  the  greatest capabilities in
responding to questions from State and local agencies evaluating toxic air pollutants; the list by no means
encompasses all of EPA.  The organization of EPA offices is shown in Figure 1. Readers are directed to the
index to locate EPA offices and  services that provide information pertaining to specific subject areas.

Addresses are provided for each office, and telephone numbers are provided for offices which can be called
directly with questions on toxic air pollutants. If it is not clear which is the most appropriate office to call,
contact the Air Risk Information Support Center (Air RISC) Hotline at 919-541-0888 (FTS 629-0888).
                                               21

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               FIGURE 1. EPA ORGANIZATION CHART
     U.S. ENVIRONMENTAL PROTECTION AGENCY
uicutM waitAI
Off MX V fH* Ğ••••*•••*••Ğ•
tf*ia GP tMMi MO a:
oğo
                            OFFICE OF THE
                         ADMmiSTMTOR/OEPUTT

                            AOMMIISTHATOH
                            22

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OFFICE OF AIR AND RADIATION (OAR)
25.     Office of Atmospheric and Indoor Air Programs (QAIAP)
       U.S. EPA
       ANR-445
       401 M Street, S.W.
       Washington, DC 20460
       202-260-7407
       FTS 260-7407
The Office of Atmospheric and Indoor Air Programs (OAIAP) manages emerging programs of cross-cutting
nature in areas of air and radiation, i.e., stratospheric ozone depletion, global warming, indoor air pollution,
and acid rain deposition. The OAIAP serves as principal program advisor to the Assistant Administrator on
issues associated with these four program areas, develops programs for the Assistant Administrator, and
then administers that strategy.

OAIAP develops, formulates, and carries out both short-and long-range studies to provide a basis for policy
decisions and a structure to implement them.  The OAIAP works closely with the Office of External Affairs
and serves as the principal source of contact and  technical assistance relative to the four program areas.
This office also administers and monitors grants and contracts relative to these program initiatives.

25.1    Acid Rain Division
       U.S. EPA
       ANR-445
       401 M Street, S.W.
       Washington, DC 20460
       202-260-9400
       FTS 260-9400
The Acid Rain Division is responsible for implementing the Acid  Rain Program established under Title IV of
the 1990 Clean Air Act Amendments. The goals of  the Acid Rain Program are (1) achieving a 10 million ton
reduction of sulfur dioxide (S02) emissions and mandated reductions of nitrogen oxide (NOx) emissions;
(2) facilitating an innovative  market-based allowance trading system that uses economic incentives to
achieve these emission reduction goals in a cost-effective manner; and (3) promoting the development and
use of pollution prevention and  energy-efficient strategies and technologies.  The  Acid  Rain Division is
developing a regulatory program that will implement these goals with significant assistance from regulators,
the regulated community, and other interested stakeholders.  The Division is also responsible for assessing
the environmental benefits of the program and implementing the recently signed U.S./Canadian Air Quality
Agreement.
                                              23

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25.2   Global Change Division

       U.S. EPA
       ANR-445
       401 M Street, S.W.
       Washington, DC  20460
       202-260-7750
       FTS 260-7750

The Global Change Division is responsible for the following activities associated with global warming and

protection of stratospheric ozone:


       •   Implementation of the requirements under Title IV of the 1990 Clean Air Act Amendments to
           develop regulations to protect stratospheric ozone

       •   Research into substitute chemicals  and technologies to assist in the search for alternatives to
           ozone-depleting substances

       •   Management of technology transfer programs on substitutes to ozone-depleting substances,
           both domestically and internationally

       •   Management of EPA's Green Lights Program, which is encouraging industry to switch to more
           energy-efficient lighting

       •   Research into energy efficient refrigerators


25.3   Indoor Air Division

       U.S. EPA
       ANR-445W
       401 M Street, S.W.
       Washington, DC  20460
       703-308-8470
       FTS 398-8470

The Indoor Air Division gathers data and information on all aspects of indoor air quality in order to contribute

to the understanding  of  health problems associated with the existence of air pollutants in the indoor

environment; coordinates Federal, State, local, and private research and development efforts related to the

improvement of indoor air quality; and assesses appropriate Federal government actions to mitigate the

environmental and health risks associated with indoor air.
26.     Office of Air Quality Planning and Standards (OAQPS)

        U.S. EPA
        MD-10
        Research Triangle Park, NC 27711
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The Office of Air Quality Planning and Standards (OAQPS) supplies EPA Headquarters and State and
Regional Offices  with technical and  regulatory information concerning air quality standards.  Working
primarily with the Clean Air Act, OAQPS develops national standards for air quality and assesses progress
in achieving air quality goals. Emissions standards for new stationary sources and hazardous air pollutants,
as well as technical policies, guidelines, and criteria for air pollution control and enforcement are developed.
The OAQPS develops and maintains a national air programs data system that includes air quality emissions
and other technical data.

The OAQPS assists State and local air pollution control agencies, EPA Regional Offices, industry, and other
organizations by providing personnel training activities through  the Air Pollution Training  Institute and
specialty workshops and technical direction regarding  all aspects  of air pollution control.  The OAQPS
evaluates Regional programs with respect to State Implementation Plans (SIPs) and strategies, as well as
resource needs and allocations for air-related programs.

26.1     Technical Support Division (TSD)
        U.S. EPA
        MD-14
        Research Triangle Park, NC  27711
        919-541-5536
        FTS 629-5536
The Technical Support Division (TSD) is responsible for the following functions:

        •  Providing detailed analysis and  national oversight of air quality, source emissions, and related
           engineering data.
        •  Developing methodology for the determination of significant trends leading to the attainment
           or nonattainment of air quality standards and preparing reports pertaining to national, State, and
           Regional trends.
        •  Developing, operating, and maintaining a national data bank for the collection and distribution
           of air quality, emissions,  and compliance data.
        •  Providing national management and support to the application of  dispersion and receptor
           models  through  evaluation  studies,  national  guidance and  regulations,  and  technical
           coordination and review  of large or nonroutine application  efforts.
        •  Conducting emission tests in  support  of  Federal standards development and evaluating
           standard test methods and providing technical guidance on the selection and application of test
           methods.
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26.1.1  Monitoring and Reports Branch (MRB)
       U.S. EPA
       MD-14
       Research Triangle Park, NC 27711
       919-541-5559
       FTS 629-5559
The Monitoring and Reports Branch (MRB) develops and issues national ambient air monitoring strategies
and program plans for both criteria and noncriteria pollutants and conducts statistical analysis of ambient
air quality and other environmental data.

26.1.2  Emission Measurement Branch (EMB)
       U.S. EPA
       MD-14
       Research Triangle Park, NC 27711
       919-541-5544
       FTS 629-5544
The Emission Measurement Branch (EMB) conducts emission tests in support of the development of
emission standards;  develops, improves, and evaluates emission sampling methods and equipment; and
provides  expertise in emission testing to other operating units.  The EMB prepares,  in regulatory format,
methods and procedures to measure emissions in order to determine compliance with NSPS, NESHAP, and
other regulations subject to Federal enforcement, and provides emission testing support to the Office of
General Enforcement and the Office of Federal Activities.  The EMB compiles and maintains test data of
emission test results and provides guidance to the Regional  Offices in establishing an emission testing
capability.

26.1.3  Source Receptor Analysis Branch (SRAB)
       U.S. EPA
       MD-14
       Research Triangle Park, NC 27711
       919-541-5561
       FTS 629-5561
The Source Receptor Analysis Branch (SRAB) selects and applies atmospheric dispersion models and other
mathematical simulation techniques to estimate concentrations of hazardous pollutants and to analyze air
quality impacts of emission standards. The SRAB serves as a focal point for technical applications of such
models and simulation techniques to EPA Regional Offices and State and local agencies.  The SRAB also
evaluates, improves, and validates atmospheric dispersion  models, selects methods for adapting such
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models and techniques to particular source and pollutant applications, and provides guidelines for applying
models and simulation techniques.

26.1.4  National Air Data Branch (NADB)
       U.S. EPA
       MD-14
       Research Triangle Park, NC 27711
       919-541-5583
       FTS 629-5583
The National Air Data Branch (NADB) develops and implements the National Aerometric Information Retrieval
System (AIRS) and installs the software, where appropriate, in State and local agencies.  The NADB works
with EPA Regional Offices  and State personnel on installing, converting, and customizing the new AIRS
software for use in managing  their air data activities, and provides technical guidance and expertise on air
quality and emissions inventories.

The NADB also operates and  maintains other national data bases which are used by EPA and State/local
agencies to collect data for air pollution research and  control  programs.  The NADB provides technical
guidance, support, and training relative to EPA's national systems and coordinates the submittal of national
air pollution data by Regional Offices and State/local agencies  to EPA.

26.2   Air Quality Management Division (AQMD)
       U.S. EPA
       MD-15
       Research Triangle Park, NC 27711
       919-541-5551
       FTS 629-5551
The  Air Quality Management Division  (AQMD)  is responsible for assuring that the various air quality
management programs and objectives  required by the Clean Air Act are implemented. These programs
generally relate to the attainment and maintenance of the national ambient air quality standards (NAAQS).
The AQMD is responsible for developing new NAAQS and for periodically reviewing and revising existing
NAAQS.  The NAAQS have  been issued for sulfur oxides, paniculate matter, nitrogen dioxide,  carbon
monoxide, ozone, and lead.

The AQMD also prepares complete regulatory analyses (economic, environmental, and energy impacts;
benefits; and benefit/cost analyses) on all ambient standard actions and prepares economic and benefit
analyses  in support  of regulatory actions of  other OAQPS Divisions, including new source performance

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standards and hazardous pollutant standards.  The AQMD develops methodologies and guidelines for
assessing benefits of air pollution control regulations, economic incentives for air pollution control, risk
assessment, and air standard decision-making.

Other air quality management programs managed by AQMD include (1) preventing significant deterioration
of air quality in clean-air areas; (2) remedying visibility impairment in national parks and wildernesses; and
(3) developing regulations and guidance for State operating permit programs.

26.2.1   Ambient Standards Branch
        U.S. EPA
        MD-12
        Research Triangle Park, NC  27711
        919-541-5656
        FTS 629-5656
The Ambient Standards Branch (ASB) is responsible for establishing, reviewing, and revising as necessary,
the national ambient air quality standards (NAAQS).  The ASB conducts regulatory impact and regulatory
flexibility analyses for the NAAQS and other major OAQPS regulations. ASB also conducts risk assessments
and exposure analyses for the NAAQS program.

In addition to the NAAQS program, ASB is responsible for assessing innovative approaches to developing
regulatory strategies, including pollution prevention and control.  The branch performs economic analyses,
risk assessment, and exposure analyses to support implementation of the Clean Air Act.  The branch is also
responsible for developing programs to integrate the implementation of Title I, ill, IV, and VI of the Clean Air
Act Amendments.

The ASB is divided into three  sections.  The Standards Development Section (SDS) is responsible for
reviewing all NAAQS in accordance with the Clean Air Act and recommending revisions on a 5-year cycle.
The SDS integrates health and  welfare effects data and prepares staff papers for review by the Clean Air
Scientific Advisory Committee.  Working through the Air Research Committee, the SDS defines future
research needs to support the NAAQS program. The section provides health and welfare effects expertise
for criteria pollutants to all parts of the air program.

The  Regulatory Strategies Section (RSS) is responsible for developing  new  and innovative  regulatory
strategies for implementing the Clean Air Act.  Such responsibility includes developing programs and
assisting other OAQPS organizations to integrate implementation across OAQPS Divisions and with other
                                              28

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Air Program Offices. The RSS conducts risk assessment and exposure analyses to support NAAQS reviews

and develops new and innovative approaches for using these analyses in implementation.


The Economic Analysis Section (EAS) is responsible for conducting regulatory impact analyses (RIAs) for

NAAQS and other major OAQPS regulations.  Methodologies for benefits and cost analyses are developed

by the section.  Regulatory flexibility analyses are prepared for the ASB, AQMD, and other OAQPS offices

and Regions as requested. Working with the economic and research community, EAS ensures a continuing

program for developing RIAs and other analytical tools to improve implementation efficiency.


26.3   Emission Standards Division (ESD)

       U.S. EPA
       MD-13
       Research Triangle Park, NC 27711
       919-541-5571
       FTS 629-5571

The Emission Standards Division (ESD) is responsible for the following functions:


       •   Developing national emission standards for hazardous pollutants  and developing  national
           performance standards for new sources.

       •   Evaluating the need to regulate potential pollutants and for proposing appropriate regulatory
           strategies.

       •   Performing economic, energy, and environmental impact studies in support of national emission
           standards.

       •   Conducting comprehensive surveys and studies of stationary source categories to determine
           the nature and magnitude of air pollution emissions, control methods and procedures,  and
           economic data.

       •   Providing  technical  assistance and documentation regarding  emission control technology,
           reviews technological developments for translation  into improved  control procedures,  and
           reviews standard development alternatives for compatibility with technology and regulatory
           authority.


26.3.1  Chemicals and Petroleum Branch (CPB)

       U.S. EPA
       MD-13
       Research Triangle Park. NC 27711
       919-541-5674
       FTS 629-5674
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The Chemicals and Petroleum Branch (CPB) performs comprehensive analyses of air emission sources and
control practices within the petroleum refining, chemical manufacturing, hazardous waste, and chemical-
using industries to form the bases for Clean Air Act new source performance standards (NSPS) and national
emission standards for hazardous air pollutants (NESHAPS), guidance on reasonably available control
technology (RACT) for VOC emissions from existing sources, and RCRA air emission standards. The Branch
also prepares control techniques, technical information, and engineering documents pertaining to the control
of air pollution emissions for these industries.  Plant visitations, emission testing, and meetings with industrial
representatives are coordinated  to  assure timely acquisition of data  and  background  information.  In
conjunction with the Standards Development Branch, CPB prepares information on the cost and economic
impact of emission control systems and develops regulations controlling air emissions under EPA authorities.

26.3.2  Industrial  Studies Branch (ISB)
        U.S. EPA
        MD-13
        Research Triangle Park, NC 27711
        919-541-5596
        FTS 629-5596
The  Industrial Studies Branch (ISB) performs comprehensive analyses of specified stationary emissions
sources and emission control practices to form the  bases for new source performance standards NSPS)
and national emission standards for hazardous air pollutants (NESHAPS). Primarily evaluating inorganic air
pollutants,  ISB also documents reasonably available control technology (RACT) for existing sources and
provides technical guidance to Regional  Offices on best available control technology (BACT) and the lowest
achievable emission rate (LAER) for specified source categories. The ISB develops coordinated programs
of plant visitations, emission testing, and  meetings with industrial representatives to assure timely acquisition
of data and background information. Information on the cost and economic impact  of emission control
systems is prepared in conjunction with the Standards Development Branch.

2S.3.3  Pollutant Assessment Branch (PAB)
        U.S. EPA
        MD-13
        Research Triangle Park, NC 27711
        919-541-5647
        FTS 629-5647
The  Pollutant Assessment Branch (PAB) conducts  exposure and risk analyses for  potentially  toxic  air
pollutants, including population exposure studies, and qualitative and quantitative cancer and noncancer risk
assessments. To accomplish these tasks, the PAB coordinates scientific activities with other OAQPS groups,

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ORD, and the Science Advisory Board. The PAB also researches and develops methodologies pertaining
to quantitative exposure and risk assessments.

In addition, the PAB coordinates the National Air Toxics Information Clearinghouse (NATICH) activities and
works with the Office of Health and Environmental Assessment and the Center for Environmental Research
Information in supporting the Air Risk Information Support Center.

26.3.4  Standards Development Branch (SDB)
       U.S. EPA
       MD-13
       Research Triangle Park, NC  27711
       919-629-5568
       FTS 629-5568
The Standards Development Branch (SDB) develops and recommends new source performance standards
(NSPS) and  national emission standards for hazardous air pollutants (NESHAPS).  Regulations are based
upon determining which of the alternative levels of control evaluated will provide optimum results consistent
with  statutory requirements, considering health, technical feasibility, cost, and economic issues. The SDB,
with  technical support from the Pollutant Assessment Branch, the Chemicals and Petroleum Branch, and
the Industrial Studies Branch, prepares, in proposal form, regulations and supporting documents for review.
The SDB receives and evaluates all comments resulting from the publication of proposed regulations prior
to developing final regulations for promulgation.

27.     Office of Mobile Sources (QMS)
       U.S. EPA
       ANR-455
       401  M Street, S.W.
       Washington, DC 20460

The  Office  of Mobile Sources provides information regarding mobile sources of  air pollution.   QMS
characterizes emissions from mobile sources and associated fueling operations, and develops programs for
their control, including assessment of each control technology's status  and in-use vehicle emissions.

In coordination with the Office of Enforcement and Compliance Monitoring  (OECM), OMS carries out a
regulatory compliance program to ensure adherence to standards,  and fosters the development of State
motor vehicle emissions inspection and maintenance programs.
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27.1    Technical Support Staff
       Emission Control Technology Division
       U.S. EPA
       Ann Arbor, Ml  48105
       313-374-8374
       FTS 374-8374
The Technical Support Staff is within the Emission Control Technology Division of the QMS.  This group is
responsible for assessing the impact of unregulated motor vehicle emissions.  This work includes assuring
adequate information is available for identifying and quantifying these emissions for current and new vehicle
technologies.  In addition, resulting ambient levels are projected for  both  localized  scenarios heavily
impacted by mobile sources and air quality control regions as a whole. These projections include short-term
higher level exposures as well as long-term lower level exposures. Projections are made for total exposure
during a person's lifetime allowing estimations of potential noncarcinogenic and carcinogenic risks. Some
of the pollutants that have been examined to date include benzene, formaldehyde and  other aldehydes,
diesel particulates, metals from catalyst attrition products, and dioxin.

28.    Office of Radiation Programs (ORP)
       U.S. EPA
       ANR-458
       401  M Street, S.W.
       Washington, DC  20460
       202-260-9600
       FTS 260-9600
The Office of Radiation Programs  (ORP)  carries out EPA's radiation protection activities.  These activities
include measuring environmental radiation levels, analyzing data concerning radiation effects, issuing
standards and guidance to limit human radiation exposures, and responding to radiological emergencies.
Radiation standards set limits on human radiation exposure levels, or on quantities or concentrations of
radioactive materials that may be released into air, water, or land.

The  ORP provides  limited technical and  analytical support to State and  local agencies that have
environmental radiation programs. The ORP conducts radiochemical analyses; performs site surveys; and,
on occasion, lends measuring equipment to other organizations.  Working with the Federal Emergency
Management Agency (FEMA), the ORP maintains nuclear accident response capabilities and assists State
and local agencies in preparing radiological emergency  response plans.
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The ORP also conducts various studies, such as radiation monitoring, assessment, and surveillance.  The

Office conducts the Radon Action Program, established to address the problem of elevated concentrations

of the radioactive gas in homes across the country. Through this program, ORP assists State governments

and the private sector in assessing and mitigating health risks due to indoor radon.


28.1     Bioeffects Analysis Branch

        U.S. EPA
        ANR-461
        401 M Street, S.W.
        Washington, DC 20460
        202-260-9640
        FTS 260-9640

The Bioeffects Analysis Branch is within the Analysis and Support Division, Office of Radiation Programs.

The  Branch conducts risk  assessments and  models  environmental pathways to determine exposure

conditions for radioactive materials.   In addition,  the Branch provides  information  on dosimetry and

biological effects of radiation.


28.2    Environmental Standards Branch

        U.S. EPA
        ANR-460
        401 M Street,  S.W.
        Washington, DC 20460
        703-308-8787
        FTS 308-8787

The Environmental Standards Branch is within the Criteria and Standards Division of the Office of Radiation

Programs.  The Branch develops standards for radionuclides under the  Atomic Energy Act, the Clean Air

Act, and other Federal authorities.


28.3    Radon Division

        U.S. EPA
        ANR-464
        401 M Street,  S.W.
        Washington, DC 20460
        202-260-9605
        FTS 260-9605

The Radon Division is responsible for the implementation of the EPA Radon Action Program. The goal of

the Radon Action Program is to  reduce the health risks of radon through partnerships with other Federal

Agencies, private sector organizations, and the  States. The Radon Division identities areas with high radon

                                              33

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levels in homes and determines the national distribution of radon levels and associated risks. The Division
identifies cost-effective control methods and stimulates the development of State and  private sector
capabilities to assess and mitigate radon problems.  The Division is also responsible for working with States
and other organizations (such as the American Public Health Association, the American Lung Association,
the American Medical Association, the National Safety Council, the Consumer Federation of America, and
the National Association of County Officials) to provide information to the public on radon and encourage
Americans to test and mitigate their homes.  Call 1-800-SOS-RADON for more information.

OFFICE OF PESTICIDES AND TOXIC SUBSTANCES (OPTS)
29.    Office of Pesticide Programs (OPP)
       U.S. EPA
       H7501C
       401  M Street, S.W.
       Washington, DC 20460
The Office of Pesticides Program (OPP) is responsible for EPA's pesticide regulatory activities (under the
authority of the Federal Insecticide, Fungicide and  Rodenticide Act (FIFRA) and several provisions of the
Federal Food, Drug, and Cosmetic Act).   This activity includes registering pesticides, reregistering old
pesticides to make sure they meet today's stringent scientific and regulatory standards, and taking regulatory
action if the risks from a pesticide are determined to be unreasonable.

29.1    Health Effects Division (HED)
       U.S. EPA
       H7509C
       401  M Street, S.W.
       Washington, DC 20460
       703-557-7351
       FTS 557-7351
The Health Effects Division  (HED) develops risk, hazard, and exposure assessments for pesticides, and
supports other divisions of OPP for decisions on registration of pesticides, reregistration, and  special
reviews.  The HED also develops registration  guidelines under FIFRA.

29.1.1  Occupational and Residential Exposure Branch (OREB)
       U.S. EPA
       H7509C
       401 M Street, S.W.
       Washington, DC 20460
                                              34

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       703-557-3536
       FTS 557-3536
The  Occupational and Residential Exposure Branch  (OREB)  evaluates and  analyzes data  on the
occupational and residential  exposure  of  humans  to  pesticides.   The  OREB  provides scientific
recommendations and technical advice to the Registration Division (RD) and the Special Review and
Reregistration Division (SRRD) on exposure considerations for pesticide registration under Sections 3, 5,18,
and 24(c) of the Federal Insecticide, Fungicide, Rodenticide Act (FIFRA), as amended.  In particular, inputs
are provided for chemicals undergoing registration, special review, and reregistration. The OREB consists
of the Registration Section, the Special Review Section, and the Reregistration Section.

29.1.2  Toxicology Branch ffOXl
       U.S. EPA
       H7509C
       401  M Street,  S.W.
       Washington, DC  20460
       703-557-7351
       FTS 557-7351
The Toxicology Branch (TOX) evaluates and analyzes lexicological data on pesticides.  The data describe
carcinogenic, mutagenic,  reproductive, neurotoxic, and teratogenic effects.  Scientists in TOX combine this
data with related exposure information to determine the risks and hazards associated with pesticide use.
The  TOX examines scientific data in a wide variety  of documents, including registration applications,
experimental use permits, State registrations under Section 24(c) of FIFRA, lab and  contract report analysis,
and special document reviews.

29.2   Environmental Fate and Effects Division (EFED)
       U.S. EPA
       H7507C
       401  M Street,  S.W.
       Washington, DC  20460
       703-557-7695
       FTS 557-7695
The  Environmental Fate and Effects Division (EFED) develops risk,  hazard, and  effects assessments for
nontarget  species for pesticides,  and supports  other divisions of OPP for decisions on registration of
pesticides, reregistration,  and special reviews based on registrant data required under FIFRA.  The EFED
also develops registration guidelines under FIFRA.
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29.2.1  Environmental Fate and Groundwater Branch (EFGWB)

       U.S. EPA
       H7507C
       401 M Street, S.W.
       Washington, DC 20460
       703-557-3935
       FTS 557-3935

The Environmental Fate and Groundwater Branch (EFGWB) develops and evaluates data on the fate,

transport, and concentration of pesticides and their degradates in the environment and integrates these data

to estimate  the  potential  to  contaminate  surface and  groundwaters and accumulate into nontarget

organisms. The EFGWB also develops and maintains pesticide data bases which include monitoring data

in the Pesticide Information Network.
29.3   Science Integration and Management Staff (SIMS)

       U.S. EPA
       TS-769C
       401 M Street, S.W.
       Washington, DC 20460
       703-557-9307
       FTS 557-9307

The Science Integration and Management Staff (SIMS) supports hazard assessment activities for pesticides

by integrating individual (discipline-specific) review components into an overall statement of risk.  SIMS
analyzes science  policy issues, and  recommends resolution  of issues  (such as inert ingredients and

contaminants in pesticide formulations, and subsurface movement of pesticides). The SIMS also represents

HED on EPA work groups and maintains  liaisons with EPA offices having scientific review and support

responsibility  and with outside scientific organizations.


30.     Office of Toxic Substances (OTS)

       U.S. EPA
       TS-792
       401 M Street, S.W.
       Washington, DC 20460


The Office of Toxic Substances (OTS)  is responsible for EPA activities mandated by the Toxic Substances

Control Act (TSCA).  Because of the broad information-gathering powers of TSCA, OTS has become an

information resource to other EPA programs.  The  OTS is involved in information collection  and data

development, and communicates TSCA activities to the chemical industry, environmental groups, and the

public.

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Policies and procedures for coordinating Agency and Federal activities concerning toxic substances are
developed by OTS.  The OTS provides  operational guidance to EPA Regional Offices, and reviews and
evaluates toxic substances activities at  both EPA Headquarters and Regional levels.  In addition, OTS
manages toxic substances research and development under the Pesticides/Toxic Substances Research
Committee.

30.1    Chemical Control Division (CCD)
       U.S. EPA
       TS-794
       401 M Street, S.W.
       Washington, DC 20460
       202-260-3749
       FTS 260-3749
The Chemical Control Division (CCD) develops and implements appropriate regulatory and non-regulatory
control measures for  new  and existing chemicals, and  for new uses  of  chemicals  found to pose
unreasonable health and/or environmental effects.  The Division manages the regulatory evaluation and
decision-making process for selecting and implementing control measures for new chemicals. The CCD
evaluates remedial control options and establishes rules for existing chemicals under TSCA. Strategies for
achieving efficient record-keeping and reconciling OTS' assessment activities with respect to new and
existing chemicals are developed by the CCD.

30.2   Existing Chemical Assessment Division (ECAD)
       U.S. EPA
       TS-778
       401 M Street, S.W.
       Washington, DC 20460
       202-260-3442
       FTS 260-3442
The Existing Chemical Assessment Division (ECAD)  manages the Toxic Substances Control Act (TSCA)
existing chemical screening, testing, and assessment programs. The ECAD is responsible for collecting data
from the chemical industry via regulatory efforts or other means.  The ECAD screens and evaluates these
data on exposure, health and safety, and environmental effects, as well as allegations of  adverse effects,
"substantial risk,"  and voluntary "For Your Information" submissions.  The  ECAD also performs  risk
assessments on selected chemicals and identifies potential  risk reduction actions for OTS.

In addition,  ECAD develops reporting and testing rules requiring the chemical industry to submit exposure-
related, health and safety, and environmental effects data to enable the Division to assess potential risks in
                                              37

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conjunction with the other OTS  Divisions.  The ECAD coordinates cooperative programs on existing
chemicals between EPA and international organizations, and provides support to the Interagency Testing
Committee and the National Toxicology Program.  The Division serves as a clearinghouse for chemical
testing activities across the Agency.  In addition, ECAD operates the Regional Risk Guidance Staff which
provides risk assessment support to the Regions on the Superfund Amendments and Reauthorization Act
(SARA) Section 313 risk-related issues and includes the Chemical Assessment Desk (see page 11).

30.3    Exposure Evaluation Division (EED)
        U.S. EPA
       TS-798
       401 M Street, S.W.
       Washington, DC 20460
       202-260-1866
        FTS 260-1866
The Exposure Evaluation  Division (EED)  is responsible for the integrated assessment  of  human and
environmental exposure in support of OTS' risk assessment activities. The Division supports CCD and ECAD
by providing assistance regarding the chemical, physical, and persistence properties of substances, and
information on  standards  and guidelines.  The EED also assists in evaluating analytical methods arid
laboratory and field techniques.  Review of data from industrial exposure assessments and the evaluation
and development of guidelines for human epidemiological studies are also conducted by EED.

30.4    Health and Environmental Review Division (HERD)
        U.S. EPA
        TS-796
        401 M Street, S.W.
        Washington, DC 20460
        202-260-1241
        FTS 260-1241
The Health and Environmental Review Division (HERD) develops and recommends science policies to OTS
concerning health and ecological effects. HERD is responsible for the initial review and detailed assessment
of harmful effects of new chemical including products  of biotechnology  on human health  and the
environment conducted under section 5 of TSCA. HERD develops and updates testing guidelines in support
of section 4 implementation; reviews, validates, and evaluates test data submitted  by industry and other
available information relevant to  harmful effects of chemicals on human health and the environment; and
performs scientific assessments of toxicity and other chemical hazards to human health and the environment
in support of the risk assessment activities of OTS.   In addition, HERD  provides technical support for
implementing the TSCA testing and existing chemicals programs and for rule development for existing
                                              38

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chemicals under section 6.  HERD also identifies and develops new methods and techniques for laboratory
testing and evaluation of chemical hazards to human health and the environment through intramural efforts,
extramural studies, and collaboration with the Office of Research and Development and academic and
international organizations.

30.5   Information Management Division (IMD)
       U.S. EPA
       TS-793
       401 M Street, S.W.
       Washington, DC  20460
       202-260-3938
       FTS 260-3938
As the focal point for all toxic chemical information in EPA Headquarters, the Information Management
Division (IMD) is responsible for all information and security services in support of activities under TSCA and
SARA Title III, Section 313 (under Section 313 of Title III, certain businesses are required to submit annual
reports on the amounts of  chemicals their facilities release into the environment, either routinely or as a
result of accidents).  In fulfilling this responsibility, IMD develops and maintains data bases, automatic data
processing (ADP) systems, and the EPA computer network.

The Confidential Data Branch of IMD  is responsible for administrating  all TSCA  confidential business
information (including operation of the  OTS Confidential Business  Information Center).  The Public Data
Branch provides nonconfidential information services, such as literature searches and  operation of the TSCA
Public Information Office.

30.6   TSCA Assistance Information Service
       U.S. EPA
       TS-799
       401  M Street, S.W.
       Washington, DC 20460
       202-554-1404
The TSCA Assistance Information Service, sponsored by the Environmental Assistance Division of the Office
of Toxic Substances, provides technical assistance and information about programs implemented under the
Toxic Substances Control  Act  (TSCA), the Asbestos School  Hazard  Abatement Act (ASHAA),  and the
Asbestos Hazard Emergency Response Act (AHERA).  Services are provided to industry, labor and trade
organizations, environmental groups, State and local governments, Federal agencies, and the general public.
TSCA Hotline staff can be reached at (202) 554-1404, Monday through Friday, from 8:30 a.m. to 5:00 p.m.,
                                              39

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EST. Publications such as Federal Register notices, informational brochures, and booklets are also available
free of charge from the TSCA Assistance Information Service.

OFFICE OF RESEARCH AND  DEVELOPMENT (ORD)
31.    Office of Modeling. Monitoring Systems, and Quality Assurance (OMMSQA)
       U.S. EPA
       RD-680
       401  M Street, S.W.
       Washington, DC 20460
       202-260-5767
       FTS 260-5767
The Office of Modeling, Monitoring Systems, and Quality Assurance (OMMSQA) is responsible for planning,
managing and evaluating a comprehensive program for (1) research with respect to the characterization and
transport and fate of pollutants that are released into the atmosphere; (2) development and demonstration
of techniques and methods to monitor human and ecological exposure and to relate ambient concentrations
to exposure of critical receptors; (3) research, development, and demonstration of new monitoring methods,
systems, techniques, and equipment for detection, identification, and characterization of pollutants at the
source and  in the ambient  environment and for  use as reference or standard  monitoring methods;
(4) establishment,  coordination, and  review  of  Agency-wide  Quality  Assurance  Program;  and
(5) development  and provision of quality assurance methods, techniques, and material including validation
and standardization of analytical methods, sampling techniques, quality control methods, standard reference
materials, and techniques for data collection, evaluation, and interpretation.

31.1    Modeling and  Monitoring Systems Staff
       U.S. EPA
       RD-680
       401  M Street, S.W.
       Washington, DC 20460
       202-260-5776
       FTS 260-5776
The Modeling and Monitoring Systems Staff is responsible for the planning, management, coordination, and
review of the Agency's research, development, and demonstration programs in the Air, Toxics, Pesticides,
Radiation, Water, and Waste Management media to define (1) techniques and systems to monitor human
and ecological exposure and relate ambient concentrations of pollutants to exposure of critical receptors;
(2) research and development  programs to characterize the atmospheric processes and transport and
transformation of air pollution  as  it relates to urban and regional atmospheres;  (3) precise, accurate
                                              40

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techniques for surveillance and enforcement requirements; (4) candidates for designation as standard or

reference monitoring methods; (5) monitoring methods and systems including sampling techniques and
methodology, and other components of monitoring systems and strategies; (6) quality assured monitoring

techniques including methods of standardization, validation and equivalency, and quality procedures and

protocols, and quality control; and (7) specialized monitoring or other systems to Agency program and

Regional Offices as well as other Federal and State agencies in response to requests for services. The Staff

provides technical expertise and management assistance in the areas noted above; develops broad Agency

policy and program plans, priorities,  and laboratory objectives; coordinates research and development

activities with other components of ORD, the Agency, Federal, State and local governments, and the private

sector;  reviews laboratory plans,  allocates resources, and  monitors the status  of  ongoing programs;
conducts or assists in conducting program reviews; and develops recommendations for corrective actions

when necessary.


31.2    Atmospheric Research and Exposure Assessment Laboratory (AREAL)

        U.S. EPA
        MD-75
        Research Triangle Park, NC 27711
        919-541-2106
        FTS 629-2106

The  Atmospheric Research  and  Exposure Assessment  Laboratory (AREAL) conducts  intramural and

extramural research programs, through  laboratory and field research,  in the chemical, physical, and

biological  sciences designed to do the following:


        •    Characterize  and quantify present  and future  ambient air pollutant levels and  resultant
            exposures to humans and ecosystems on local, regional, and global scales;

        •    Develop and validate  models to  predict changes in air  pollution levels  and air  pollutant
            exposures and determine the relationships among the factors affected by  predicted and
            observed changes;

        •    Determine  source-to-receptor relationships relating to ambient air quality and air  pollutant
            exposures, developing predictive models to be used for assessments of regulatory alternatives
            derived from these relationships, directly or indirectly;

        •    Provide support to Program and Regional Offices and to State and local groups,  in the form
            of technical advice, methods research and development, quality assurance, field monitoring,
            instrument development,  and modeling  for  quantitative  risk assessment  and regulatory
            purposes;

        •    Develop and carry out long-term research in the areas  of atmospheric methods, quality
            assurance, biomarkers, spatial statistics, and exposure assessment;
                                              41

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       •   Collect, organize, manage, and distribute research data on air quality, human and ecosystem
           exposures and trends for Program and Regional Offices, ORD, the scientific community, and
           the public at large.

32.    Office of Technology Transfer and Regulatory Support (OURS)
       U.S. EPA
       H8105
       401 M Street, S.W.
       Washington, DC 20460
       202-260-7669
       FTS 260-7669
The Office of Technology Transfer and Regulatory Support (OTTRS) provides technical and policy assistance
to the Office of Research and Development (ORD) laboratories.   It also serves as a focal point for
communication  and coordination with  EPA program offices,  EPA Regional  Offices,  and non-EPA
organizations including State  and local agencies, universities, and other Federal agencies.  The OTTRS
disseminates  ORD scientific and engineering information through its Center for  Environmental Research
Information (CERI) and provides EPA Program Offices with recommendations for integrating this information
into the regulatory decision-making process.

32.1    Center for Environmental Research Information  (CERI)
       U.S. EPA
       26 West Martin Luther King Drive
       Cincinnati, OH  45268
       513-684-7391
       FTS 684-7391
The  Center for Environmental Research Information (CERI) is  the focal point  for all ORD  information
products.  Its responsibilities are in two broad areas:  Technical Information Product Management and
Technology Transfer.  CERI's product management activities include establishing and maintaining ORD's
technical information policy; final production, printing, and distributing all ORD reports; developing special
reports when needed; and producing ORD project summaries. The Technology Transfer Staff anticipates
adverse impacts of Agency regulatory and enforcement activities.  With  the help of  ORD research staff,
academia, and the scientific and engineering components of the  private sector, strategies and information
tools are  developed and  disseminated  to  alleviate  these impacts.   For example,  the  staff develops
information for solving municipal and industrial environmental problems through the application of control
technology and makes these solutions available to carefully selected target audiences through seminars and
related publications.
                                               42

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The ORD Publications Announcement is published four times a year to provide interested parties with access
to the broad range of currently available documents produced by the ORD.  To receive a copy of this
announcement, contact the Publications Unit at 513-569-7562.  Orders are filled until the supply of a
particular report is exhausted.

33.    Office of Environmental Processes and Effects Research (OEPER)
       U.S. EPA
       RD-682
       401 M  Street, S.W.
       Washington, DC 20460
The Office of Environmental Processes and Effects Research (OEPER) develops scientific and technological
methods for managing the entry, movement, and fate of pollutants in the environment. The effects of
pollutants on nonhuman organisms and ecosystems are researched.  The OEPER consists of research
facilities in Ada, Oklahoma; Athens, Georgia; Corvallis, Oregon; Duluth, Minnesota; Narragansett, Rhode
Island; and Gulf Breeze, Florida. The Corvallis Environmental Research Laboratory (CERL) assesses the
ecological effects of airborne pollutants; other laboratories focus on aquatic, multimedia, and soil systems.
The Environmental Processes and Effects Staff are responsible for planning and management of research,
including biotechnology risk assessment; wetland research; dredge disposal/contaminated sediments; global
change; contaminated land sites; oil spills;  estuarine and near-coastal waters; distributed landscapes and
freshwater systems; Arctic regions; groundwater; and biodiversity.

34.    Office of Health and Environmental Assessment (OHEA)
       U.S. EPA
       RD-689
       401 M Street, S.W.
       Washington, DC 20460
The Office of Health  and Environmental Assessment (OHEA)  is the EPA's focal point for the scientific
assessment of the degree of risks imposed by environmental pollutants in varying exposure situations on
human health and ecological systems.  OHEA occupies a critical position in the Office of Research and
Development (ORD) between (1) the researchers in other ORD components who are generating new findings
and data, and (2) the regulators in the EPA Regional  and program offices who must make regulatory,
enforcement, and remedial action decisions. In support of its mission to provide EPA with assessments of
risk to human health and the environment, OHEA carries out three functions:
                                              43

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            Prepare human health risk assessments that serve as the scientific basis for regulatory and
            enforcement decisions within EPA.

            Promote Agency-wide  coordination and consistency of risk  assessments by  preparing
            guidelines; by providing expert advice, reviews and data analysis; and by participating in the
            regulatory decision-making process.

            Plan and conduct research to reduce uncertainties in risk assessment.
34.1    Human Health Assessment Group (HHAG)

       U.S. EPA
       RD-689
       401 M Street, S.W.
       Washington, DC 20460
       202-260-5898
       FTS 260-5898

The Human Health Assessment  Group (HHAG) provides state-of-the-art methodology, guidance,  and

procedures on the health risks associated with suspected cancer-causing agents and the risks associated

with  chemicals that are suspected  of  causing  detrimental  reproductive effects, including  mutagenic,

teratogenic, and other adverse reproductive outcomes and reduced fertility;  assures quality and consistency

in the Agency's scientific risk assessments; provides advice on proposed testing requirements for adequate

risk assessments; and prepares independent risk assessments.


34.2    Exposure Assessment Group (EAG)

       U.S. EPA
       RD-689
       401 M Street, S.W.
       Washington, DC 20460
       202-260-8909
       FTS 260-8909

The Exposure Assessment Group (EAG) provides advice on the exposure characteristics and factors of

agents that are suspected of causing detrimental health effects; provides state-of-the-art methodology,

guidance, and procedures for exposure determinations; assures quality and consistency in the Agency's

exposure  assessments,  and prepares  independent assessments  of exposure  and recommendations

concerning the exposure potential of specific agents.
                                              44

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34.3   Environmental Criteria and Assessment Office-Cincinnati (ECAO-Cin)
       U.S. EPA
       26 W. Martin Luther King Drive
       Cincinnati, OH 45268
       513-569-7531
       FTS 684-7531
The primary function  of ECAO-Cin is the development of noncancer human health risk assessments to
various EPA programs, Regional Offices, and State, local, and international agencies.

In the air quality  program, ECAO-Cin develops health  risk assessments and summaries  for airborne
contaminants, which includes maintenance of court files and disposition of public documents. The ECAO-
Cin also prepares the risk assessments for hazardous substances found at uncontrolled hazardous waste
sites and identified by EPA's Office of Solid Waste and Emergency Response.

The ECAO-Cin supports the Air Risk Information Support Center (Air RISC), providing technical assistance
to State and local air agencies and EPA Regional Offices on issues related to health,  risk, and exposure
assessments. ECAO-Cin developed and maintains the Integrated Risk Information System (IRIS) data base
and the Health Effects Assessment Summary Table (HEAST) for the Agency. Direct and indirect exposure
methodologies are being  developed for Municipal Waste Combustors (MWCs), and the Lead Biokinetic
Exposure Model is presently  being tested by the Regions.  When appropriate, ECAO-Cin coordinates
workshops concerning chemical-specific exposures or new state-of-the-art risk assessment methodologies.

34.4   Environmental Criteria and Assessment Office-Research Triangle Park (ECAO-RTP)
       U.S. EPA
       MD-52
       Research Triangle Park, NC 27711
       919-541-4173
       FTS 629-4173
The primary mission of the Environmental Criteria and Assessment Office-Research Triangle Park (ECAO-
RTP) is the assessment and interpretation of scientific information in support of EPA regulatory decision-
making,  especially with regard to air-related standards. This function is accomplished via preparation and
publication of (1) new or  revised air quality criteria documents used in setting national ambient air quality
standards (NAAQS) under the Clean Air Act, Sections 108 and 109; (2) scientific assessments serving as
the basis in decisions on listing and regulating hazardous air pollutants under the Clean Air Act, Sections
111 and  112; and (3) other special reports as required by various legislative authorities. The ECAO-RTP also
serves as an important Agency focal point for (1) identification and communication of gaps in air-related data

                                              45

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bases and research necessary to address such gaps; (2) provision of scientific assessment support to EPA
Regions and State and  local agencies in dealing with specific air toxic problems;  and (3) coordination/
organization of the ORD scientific assessment and information exchange concerning air-related health and
environmental effects in connection with international activities.

The ECAO-RTP is the head office for coordination of the ORD support to the Air Risk Information Support
Center; requests for assistance submitted to this office for health or risk assessment information are handled
by ECAO-RTP, or referred, as appropriate to others ORD staff (primarily OHEA).

35.     Office of Health Research (OHR)
        U.S. EPA
        RD-683
        401 M Street, S.W.
        Washington, DC 20460
The  Office of Health Research (OHR) is the focal point for lexicological, clinical, and epidemiological
research within  ORD.   The OHR formulates and implements  a comprehensive  research program to
investigate human health effects associated with exposure to environmental pollutants and assists in the
formulation of health science policy for EPA. The OHR evaluates and communicates its research results and
provides advice  on their use to EPA offices for criteria development and scientific assessments in support
of regulatory and standard setting activities.

35.1     Health Effects Research  Laboratory (HERL)
        U.S. EPA
        MD-51
        Research Triangle Park,  NC  27711
        919-541-2281
        FTS 629-2281
The Health Effects Research Laboratory (HERL) investigates human health effects resulting from exposure
to environmental pollutants.  Staffed by health scientists with recognized expertise in a variety of disciplines
(environmental medicine, physiology, epidemiology, statistics, biochemistry, neurotoxicology, reproductive
toxicology,   teratology   and  perinatal  toxicology,   geriatric  toxicology,   pulmonary  toxicology,
immunotoxicology, cardiovascular toxicology, genotoxicology,  hepatotoxicology and  other target organ
toxicology, and microbiology), HERL is the primary laboratory for toxicological, clinical, and epidemiological
research within the Agency.  HERL also establishes cooperative research projects with academic and other
scientific institutions which facilitate the Agency's efforts in understanding health effects of environmental
                                                46

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pollutants. This research program develops and applies state-of-the-science biological assays, predictive
models, and extrapolation methods which serve as the basis for the Agency's health risk assessments.

35.1.1   Genetic Toxicology Division (GTD)
        U.S. EPA
        MD-68
        Research Triangle Park, NC 27711
        919-541-2537
        FTS 629-2537
The research program of the Genetic Toxicology Division (GTD) encompasses the fields of mutagenesis,
carcinogenesis, and  related  studies in cellular toxicology.  The  GTD possesses the capability of fully
evaluating the mutagenic and oncogenic potential of agents of  environmental  concern including pure
chemicals and complex environmental mixtures.  The GTD has major research programs in improving risk
assessment  procedures, applying biomarkers to environmental health studies,  improving the basis for
heritable mutation  risk assessment, and  application of structure  activity relationship  methods (SAP) to
environmental toxicology. The GTD has new updated material on its data bases on genetic toxicology and
carcinogenesis.

35.1.2  Neurotoxicoloav Division (NTD)
        U.S. EPA
        MD-74B
        Research Triangle Park, NC 27711
        919-541-2671
        FTS 629-2671
The Neurotoxicology Division (NTD) is the focal point for planning, conducting, coordinating, supporting,
and evaluating a program aimed at studying the effects of physical and/or chemical agents on nervous
system function. The program includes both intramural investigations and extramural  arrangements with
universities,  industry, private research institutions, and other government agencies.  The overall program
strategy stresses the development of cost-effective testing methods for evaluating neurotoxicity and for
predicting risk to humans. Within the framework of this strategy, five overall objectives have been identified:
(1) methods development and validation, including evaluation of existing  methods, design  and evaluation
of new methods, and development of testing strategies; (2) toxicity evaluation; (3) determinations of the
significance of neurotoxicological indicators for assessing risk in humans; (4) developmental neurotoxicology
(behavioral teratology) which evaluates the effects of perinatal toxicant exposure on the development of the
nervous system; and (5) mechanism of action studies.
                                               47

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35.1.3  Research Support Division (RSD)
       U.S. EPA
       MD-55
       Research Triangle Park, NC  27711
       919-541-2883
       FTS 629-2883
The Research Support Division (RSD) is responsible for the coordination and staff work on administrative
management, data processing, statistics, technical support, and scientific activities in support of the research
programs and regulatory assistance activities in the Health Effects Research Laboratory (HERL) and the
Office of Health Research (OHR). Specifically,  the RSD is responsible for the following areas: providing
administrative management leadership to HERL, serving as liaison between HERL and other administrative
organizations, developing HERL administrative policies and interpreting those developed by EPA, ORD, and
OHR; providing  OHR-wide automated  data processing  support for both  scientific and administrative
computer systems;  providing  statistical  and mathematical  support  to  all  components  of HERL;
communicating both management and scientific information to individuals inside and outside the Agency;
managing the HERL  quality  assurance  program,  laboratory animal  procurement and husbandry, and
contracts to support HERL's management and research programs; and assisting with scientific and technical
issues within HERL by undertaking special projects which are of critical importance to the Laboratory.

35.1.4  Environmental Toxicology Division (ETD)
       U.S. EPA
       MD-66
       Research Triangle Park, NC  27711
       919-541-2655
       FTS 629-2655
The Environmental Toxicology Division (ETD) conducts research to determine the health effects of inhaled
environmental  pollutants.  Particular  emphasis is placed on the development and application of improved
methods which enable significant advancement in the knowledge of the health effects of air  pollutants. The
ETD serves as a primary technical resource within the Agency for activities  requiring expertise in animal
inhalation studies and  in the health effects of common air pollutants. Continual efforts are made to improve
the correlation between animal and human studies and extrapolation models are developed to enable better
risk assessments to be made.  These extrapolation models are founded on physiologically-based dosimetry
models for compounds that have been ingested, inhaled, or dermally applied.  Methods for the isolation and
identification of chemicals and metabolites in tissues arid biological fluids are developed and then applied
in experimental dosimetry research programs. Issues such as route-to-route, acute-to-chronic, and animal-
to-man extrapolation are addressed.

                                               48

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35.1.5  Developmental Toxicology Division (DTD)
       U.S. EPA
       MD-71
       Research Triangle Park, NC  27711
       919-541-2771
       FTS 629-2771
The Developmental Toxicology Division (DTD) conducts and manages biological research on the effects of
environmental pollutants, singly or in combination, on reproduction and development. The chemical agents
under investigation include toxic substances, pesticides, air pollutants, drinking water contaminants, and
hazardous wastes.  Major research emphasis is on the development of new and improved methodologies
for the assessment of male and female reproductive toxicity, embryo and fetal toxicity,  and postnatal
functional deficits.

35.1.6  Human Studies Division (HSD1
       U.S. EPA
       MD-58
       Research Triangle Park, NC  27711
       919-966-6200
The Human Studies Division (HSD)  conducts clinical and epidemiological investigations to improve the
understanding of human health risks associated with environmental pollution. Clinical studies are conducted
for research questions which are best approached experimentally by monitoring or administering exposures
under highly controlled laboratory settings or where the evaluation of effects requires complex laboratory
procedures. Epidemioiogic  investigations study humans in less rigidly controlled, more natural settings by
field studies or analysis of existing data. Laboratory analyses are used to improve assessments of exposure,
biologically relevant doses, and adverse biological or health effects, as well as to investigate mechanisms
linking these phenomena. Studies are frequently designed and analyzed so as to characterize the similarities
or differences between effects observed in humans and animals or in vitro systems; the data are then used
by the Agency for risk assessment in the absence of human data.

36.     Risk Assessment Forum
       U.S. EPA
       RD-689
       401 M Street, S.W.
       Washington, DC 20460
       202-260-6743
       FTS 260-6743
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The Risk Assessment Forum is made up of 18 senior EPA scientists.  Its objective is to promote consensus
on risk assessment issues and ensure incorporation of this consensus into risk assessment guidance. The
Forum performs risk assessment projects selected in collaboration with the Risk Assessment Council, which
was established in 1986 by the Administrator to provide executive oversight of risk assessment policies at
EPA.

The Forum assists EPA's policy making in three ways: (1) develops positions on science policy issues for
use in risk assessment; (2) develops EPA risk assessment guidelines and comments on procedures not
covered by EPA published guidelines; and (3) recommends revisions  to the guidelines whenever such
revisions appear to be necessary.

OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE (OSWER)
37.      Office of Emergency and Remedial Response (OERR)
        U.S. EPA
        OS-200
        401 M  Street, S.W.
        Washington, DC 20460
The  Office of  Emergency and  Remedial  Response  (OERR)  is responsible for development and
implementation of a national strategy, technical policies, regulations, and guidelines for control of abandoned
hazardous waste sites. The OERR also responds to and acts to prevent oil and hazardous substance spills.

37.1     Hazardous Site Control Division  (HSCD)
        U.S. EPA
        OS-220W
        401 M  Street, S.W.
        Washington, DC 20460
        703-308-8313
        FTS 308-8313
The Hazardous Site Control Division (HSCD) is responsible for developing and evaluating remedial action,
negotiating and monitoring remedial targets and progress, and providing policy and technical guidance on
costs, construction, data quality and field procedures, and site evaluation at Superfund sites.
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37.2   Hazardous Site Evaluation Division (HSED)

       U.S. EPA
       OS-230
       401 M Street, S.W.
       Washington, DC  20460
       202-260-8602
       FTS 260-8602

The Hazardous Site  Evaluation Division (HSED) is responsible for managing site discovery activities and

overseeing site evaluation. The HSED develops policies and protocols for chemical analysis and monitoring,

and proposes and promulgates the National Priority List updates. In addition, HSED develops policies and

procedures for evaluating health risks at Superfund sites.


37.3   Emergency Response Division (ERD)

       U.S. EPA
       OS-210
       401 M  Street, S.W.
       Washington, DC  20460
       202-260-8720
       FTS 260-8720

The Emergency Response Division (ERD) responds to hazardous substance releases or threats of releases

and initiates removal actions.  The ERD is responsible for response guidance and regulations, and provides

support for on-site response actions. The ERD manages the Superfund Hotline and provides support for

implementation of the Preparedness Program; manages the oil dispersants program and promulgates

regulations on  oil  discharge requirements; and develops reportable quantities regulations and maintains

emergency response data bases.


37.4   Office of Program Management (OPM)

       U.S. EPA
       OS-240
       401 M  Street, S.W.
       Washington, DC  20460
       202-260-2441
       FTS 260-2441
The Office of Program Management (OPM) has a variety of responsibilities within OSWER, including budget
preparation, training, technology transfer, and cross media analysis. The OPM carries out the State Capacity
Assurance Program for management of hazardous waste.
                                             51

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OFFICE OF THE ADMINISTRATOR

38.     Office of Cooperative Environmental Management

       U.S. EPA
       A-101F6
       401 M Street, S.W.
       Washington, DC 20460
       202-260-9741
       FTS 260-9741

The  Agency-wide Technology Transfer  Staff  is responsible for assisting  and coordinating technical

assistance, training, and information dissemination among EPA programs and with State and local agencies,

business and industry, and academia.  The Staff helps develop and implement communication networks,

disseminate information on effective programs and processes, and build cooperative programs between

governments and the private sector.
                                             52

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                                         SECTION III
                        EPA REGIONAL INFORMATIONAL RESOURCES

The EPA maintains 10 Regional Offices that coordinate Agency activities with State and local agencies and
the public and private sectors within specific geographic areas.  Table 1 provides addresses and general
telephone numbers for each Regional Office. Figure 1 illustrates the coverage, by State, of each Region.

Regional contacts in four key subject areas (air toxics, library services, Superfund, and RCRA) are provided
in Table 2. These persons can provide information on regional information sources and respond to many
questions State and local agency personnel may have relating to toxic air pollutants.  In addition, Regional
contacts  for the chemical assessment desk are listed on page  12, and Regional Account Managers for
access to the TRI data base are listed on page 9. If there is a question as to the appropriate person to
contact, the Air RISC Hotline (919-541-0888; FTS 629-0888) should be  contacted for assistance.
                                              53

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                             TABLE 1. EPA REGIONAL OFFICES
EPA Region I
J.F.K. Federal Building, Rm. 2203
Boston, MA 02203-2211
FTS: 835-3420
Com:  (617) 565-3420
EPA Region II
Jacob K. Javits Federal Plaza
New York, NY  10278
FTS: 264-2657
Com:  (212) 264-2657

EPA Region III
841 Chestnut Building
Philadelphia, PA 19107
FTS: 597-9800
Com:  (215) 597-9800
EPA Region IV
345 Courtland Street, N.E.
Atlanta, GA 30365
FTS: 257-4727
Com:  (404) 347-4727

EPA Region V
230 South Dearborn Street
Chicago,  IL 60604
FTS: 353-2000
Com:  (312) 353-2000
EPA Region VI
1445 Ross Avenue
12th Roor, Suite 1200
Dallas, TX  75202-2733
FTS: 255-6444
Com:  (214) 655-6444

EPA Region VII
726 Minnesota Avenue
Kansas City, KS  66101
FTS: 276-7000
Com:  (913) 551-7000

EPA Region VIII
999 18th Street
Denver Place  Suite 500
Denver, CO 80202-2405
FTS: 330-1603
Com:  (303) 293-1603

EPA Region IX
75 Hawthorne Street
San Francisco, CA 94105
FTS: 484-1305
Com:  (415) 744-1305

EPA Region X
1200 Sixth Avenue
Seattle, WA 98101
FTS: 399-1200
Com:  (206) 442-1200
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FIGURE 2. EPA REGIONAL OFRCES - COVERAGE BY STATE
                 EPA REGIONAL OFRCES
Region/State
4-Alabama
10-Alaska
9-Arizona
6-Arkansas
9-Califomia
8-Colorado
1 -Connecticut
3 -Delaware
3-O.C.
4-FIorida
4-Georgia
9-Hawaii
10-ldaho
5-lllinois
5-lndiana
7-lowa
7-Kansas
4-Kentucky
6-Louisiana
Region/State
1 -Maine
3-Maryland
1 -Massachusetts
5-Michigan
5-Minnesota
4-Mississippi
7-Mlssouri
8-Montana
7-Nebraska
9-Nevada
1-New Hampshire
2-New Jersey
6-New Mexico
2-New York
4-North Carolina
8-Nortfi Dakota
5-Ohlo
6-Oklahoma
10-Oregon
Region/State
3-Pennsyivania
1 -Rhode Island
4-South Carolina
8-South Dakota
4-Tennessee
6-Texas
8-Utah
1 -Vermont
3-Virginia
10-Washington
3-West Virginia
5-Wlsconsin
8-Wyoming
9-American Samoa
9-Guam
2-Puerto Rico
2-VIrgin Islands


                     55

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                                  TABLE 2. REGIONAL CONTACTS IN FOUR KEY SUBJECT AREAS*
en
o
REGION
1
II
III
IV
V
VI
VII
VIII
IX
X

AIR TOXICS
Tom D'Avanzo
(617) 565-3232
FTS 835^502
Alison Devine
(212) 264-9893
FTS 264-9893
Iz Milner
(215) 597-9090
FTS 597-9090
Van Shrieves
(404) 347-2864
FTS 257-2864
Bruce Varner
(312) 886-6793
FTS 886-6793
Tom Driscoll
(214) 655-7223
FTS 255-7223
Wayne Kaiser
(913) 551-7603
FTS 276-7603
Laura Lonowskl
(303) 330-1761
FTS 330-1 761
Ken Bigos
(415) 744-1240
FTS 484-1240
Elizabeth Waddell
(206) 553-8578
FTS 399-8578
LIBRARY SERVICES
Peg Nelson
(617) 565-3298
FTS 835-3298
Magi Malone
(212) 264-2881
FTS 264-2881
Diane McCreary
(215) 597-0580
FTS 597-0580
Priscilla Pride
(404) 347^216
FTS 257-4216
Lou Tilley
(312) 353-2022
FTS 353-2022
Beverly Negri
(214) 655-6444
FTS 255-6444
Barbara MacKinnon
(913) 551-7241
FTS 276-7241
Peg Hooper
(303) 330-1444
FTS 293-1444
Linda Sunnen
(415) 556-6606
FTS 556-6606
Julienne Sears
(206) 442-1289
FTS 399-1289
SUPERFUND
Rose Toscano
(617) 565-3280
FTS 835-3280
Alison Devine
(212) 264-9893
FTS 264-9893
Patricia Flores
(215) 597-9134
FTS 597-9134
Lee Page
(404) 347-2864
FTS 257-2864
Carl Nash
(312) 886-6043
FTS 886-6043
Mark Hansen
(214) 655-7223
FTS 255-7223
Wayne Kaiser
(913) 551-7603
FTS 276-7603
Norm Huey
(303) 293-0969
FTS 564-0969
Kathy Diehl
(415)744-1133
FTS 484-1 133
Chris Hall
(206) 553-1949
FTS 399-1949
RCRA
Mike McGagh
(617) 223-5634
FTS 833-1634
Terry Ippolito
(212) 264-2980
FTS 264-2980
Susan Lament
(215) 597-4081
FTS 597-4081
Cart Terry
(404) 347-3004
FTS 257-3004
Suzanne Kircos
(312) 363-3209
FTS 373-3209
Vicky Finch
(214) 655-6790
FTS 255-6790
Dale Armstrong
(913) 551-7316
FTS 276-7316
Hal Dunning
(303) 294-1142
FTS 330-1 142
Carrie Johnston
(415) 744-2185
FTS 484-2185
Bud Loiselle
(206) 563-6901
FTS 399-6901
      *Tnls list Is current as of August 1991.

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                                        SECTION IV
                                KEY REFERENCE MATERIALS

Section IV lists several key reference materials related to health, exposure, and risk assessments for toxic
pollutants.  These resources  include health and  exposure assessment  documents, risk  assessment
documents, occupational safety and health references, and chemical-specific profile documents. Information
on how to obtain each reference is also listed.
                                             57

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Annual Report on Carcinogens. 5th Report.  National Toxicology Program.  Washington, DC:  National
Technical Information Services, 1989.
National Technical Information Services
5285 Port Royal Road
Springfield, VA 22161
703-487-4650
FTS 737-4650
NTIS: PB89-231914-XAB $67.00                                       PC A99 (paper copy) $60.00
The Department of Public Health and Human Services is required by law to publish this annual report which
contains a list of all substances which either are known to be or which may reasonably be anticipated to
be carcinogens, and to which a significant number of people in the U.S. are exposed. The report provides
available information on the nature of the exposures, the estimated number of potentially exposed people,
and the effect of Federal regulations on the level of risk to public health from exposure to these substances.

Bibliography  of  Selected Reports and  Federal  Register  Notices  Related  to Air
Toxics: Volume  1: Citations: Volume 2:  Citations-1988: lndex-1988.  Environmental Protection Agency,
Office of Air Quality Planning and Standards, Research Triangle Park, North Carolina:  July 1988.
National Air Toxics Information Clearinghouse
U.S. EPA
Office of Air Quality Planning and Standards
Research Triangle Park, NC 27711
(919) 541-0850
FTS 629-0850
The National  Air Toxics  Information  Clearinghouse Bibliography provides citations for reports and
Federal Register notices related to toxic air pollutants.  The citations include documents on the following
topics: accident prevention/emergency response, ambient monitoring, case studies evaluated by State and
local agencies, Chemical Hazard Information Profiles prepared by EPA's Office of Toxic Substances, control
technology, dispersion modeling, emission factors, exposure assessments, epidemiological studies, health
assessments, indoor  air pollutants,  national emission standards for hazardous air pollutants, new source
performance standards,  air toxics program support, preregulatory assessments, regulatory development
guidance,  risk assessments, air toxics  rules and regulations, source assessments, source sampling, and
toxicity testing.

The reports selected for this bibliography were published by the following organizations: U.S. Environmental
Protection  Agency,  National Academy  of Sciences, National Cancer  Institute,  National Institute of
Environmental Health Sciences, National Toxicology Program, National Institute for Occupational Safety and
                                              58

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Health, Consumer Products Safety Commission, World Health Organization  including  the International

Agency for Research on Cancer, and various State and local agencies.


The document numbers are:


Volume I  - Citations, July 1987, EPA-450/5-87-005

Volume II - Citations, July 1988, EPA-450/5-88-005

Index - 1988, July 1988, EPA-450/5-88-006

Federal, State and local agencies may obtain copies of these reports by contacting the Clearinghouse staff
at (919) 541-0850; FTS  629-0850.



Chemical Emergency Preparedness Program (CEPP)/SARA Title III. Section 302 Profiles

SARA Title III Hotline
Office of Solid  Waste and Emergency Response (OS-120)
U.S. EPA
401 M Street, S.W.
Washington, DC 20460
1-800-535-0202
703-920-9877
Monday through Friday, 8:30 a.m. to 7:30 p.m., EST

These profiles  contain a summary of publicly available documented information for the chemicals listed

under SARA Title III, Section 302 as extremely hazardous substances.  There are 366 chemical profiles (as

of February 1988) that  contain acute hazard information,  chemical properties, and emergency handling

techniques.


Chemical Hazard Information Profiles (CHIPs)

Environmental  Assistance Division (TS-799)
U.S. EPA
TSCA Assistance Information Service
401 M Street, S.W.
Washington, DC 20460
202-554-1404
Monday through Friday, 8:30 a.m. to 5:00 p.m., EST

Chemical Hazard Information Profiles (CHIPs) are summaries of readily available information on health and

environmental effects, as well as exposure-related data. Published by the EPA's Office of Toxic Substances,

CHIP candidates are chosen  on the basis of information indicating  a  potential  for adverse health  or
                                              59

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environmental effects, evidence of significant production or other exposure potential, and commercial use

patterns regulated under the Toxic Substances Control Act (TSCA).  CHIPs (up to five per request) can be

obtained from the TSCA Assistance Information Service at 202-554-1404.


Exposure Assessments (EA)

National Technical Information Services (NTIS)
5285 Port Royal Road
Springfield, VA 22161
703-487-4650
FTS 737-4650

Exposure Assessments (EAs) assess the magnitude, frequency, duration, and route of human exposures

occurring at a specific site as a result of an industrial operation or the dumping of hazardous materials. EAs

are prepared for various EPA program and Regional Offices and support EPA's regulatory and enforcement

programs.


"For Your Information" (FYI) Reports

Environmental Assistance Division (TS-799)
U.S. EPA
TSCA Assistance Information Service
401 M Street, S.W.
Washington, D.C.  20460
202-554-1404

"For Your Information" (FYI) Reports are  submitted voluntarily to  the EPA by chemical manufacturers,

processors and distributors, trade associations, labor organizations, Federal, State and local agencies,

foreign governments, academia, public interest and environmental groups, and the general public.

The reports contain unpublished chemical toxicity and  exposure data. They do not meet the statutory

requirements for submission under TSCA but may be pertinent to risk assessment and  risk management

activities.


Health Assessment Documents (HADs)

National Technical Information Services (NTIS)
5285 Port Royal Road
Springfield, VA 22161
703-487-4650
FTS 737-4650

Health Assessment Documents (HADs) are comprehensive evaluations of the known health data, including

carcinogenicity, mutagenicity, and developmental and  reproductive effects from exposure to particular


                                              60

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chemicals or compounds. The HADs serve as the scientific data base for establishing relationships between
exposure concentrations and potential health risks and are used by the Office of Air Quality Planning and
Standards (OAQPS) to determine the possible listing of hazardous air pollutants (HAPs) under Sections 111
and 112 of the Clean Air Act.

Health Effects Assessments  (HEAs)
National Technical Information Services (NTIS)
5285 Port Royal Road
Springfield, VA 22161
703-487-4650
FTS 737-4650
Health Effects Assessments (HEAs)  are preliminary assessments  of relevant health effects data.  The
documents  are used  in evaluating risk at  uncontrolled sites  and for appraising clean-up alternatives in
remedial  investigations and feasibility studies.

Health and Environmental Effects Documents (HEEDs)
National Technical Information Services (NTIS)
5285 Port Royal Road
Springfield, VA 22161
703-487-4650
FTS 737-4650
Health and Environmental Effects Documents (HEEDs) are summaries of the literature concerning health
hazards associated with environmental exposures to particular chemicals or chemical compounds.  These
documents are prepared to aid in the development of waste characterization regulation under Section 3001
of the Resource Conservation and Recovery Act (RCRA) and to provide health-related limits and goals for
emergency and remedial actions under the Comprehensive Environmental Response, Compensation and
Liability Act  (CERCLA/Superfund).  HEEDs contain Health Affects Assessments  (HEAs) and reportable
quantities (RQs) and supercede previously developed Health  and Environmental Effects  Profiles (HEEPs)
and Hazard Profiles. HEEDs may contain refernce doses (RfDs) for short- and long-term exposure for both
inhilation and oral exposure,  or, in the case of carcinogens, a carcenogenic potency factor. HEEDs become
part of the RCRA and CERCLA public dockets.
                                              61

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Health and Environmental Effects Profiles (HEEPs)

National Technical Information Services (NTIS)
5285 Port Royal Road
Springfield, VA 22161
703-487-4650
FTS 737-4650

Health and Environmental Effects Profiles (HEEPs) aid the Office of Solid Waste and Emergency Response

(OSWER) in developing waste characterization regulations under the Resource Conservation and Recovery

Act (RCRA).  The HEEP documents are summaries of literature concerning health hazards associated with

environmental exposures to certain RCRA chemicals.


National Institute for Occupational Safety and Health (NIOSH) Criteria Documents (NIOSHCRIT)

NIOSH Publications
4676 Columbia Parkway
Cincinnati, OH 45226

Any titles not available through NIOSH can be obtained through the following:

Superintendent of Documents
U.S. Government Printing Office (GPO)
Washington, DC  20402

or

National Technical Information Services (NTIS)
5285 Port Royal Road
Springfield, VA 22161
703-487-4650
FTS 737-4650

These Criteria Documents summarize the National  Institute for Occupational Safety and Health (NIOSH)

rationale for  recommended exposure limits for chemicals presenting human health risks in the workplace.

These documents are passed on to the Secretary of Labor for consideration for use in developing regulatory

standards.
                                             62

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National Air Toxics Information Clearinghouse:  Qualitative and Quantitative Carcinogen Risk Assessment.
EPA 450/5-87-003.   Environmental Protection Agency, Office of Air Quality Planning and  Standards,
Research Triangle Park, North Carolina: 1987.
National Air Toxics Information Clearinghouse
U.S. EPA
Office of Air Quality Planning and Standards (MD-13)
Research Triangle Park, NC 27711
919-541-0850
FTS 382-0850
The National Air Toxics Information Clearinghouse has been established by the EPA Office of Air Quality
Planning  and Standards (OAQPS)  in coordination with the State and Territorial Air Pollution  Program
Administrators (STAPPA) and the Association  of Local Air Pollution  Control Officials (ALAPCO) for the
purpose of aiding information transfer among Federal, State, and local air quality management agencies.
This report has been published as part of that  effort.  The purpose of this report is to describe the basic
principles and assumptions associated with a qualitative and quantitative carcinogenic risk assessment to
help State and local agencies better understand and interpret a risk assessment. The report discusses the
four steps of risk assessment: hazard identification, dose-response assessment, exposure assessment, and
risk characterization,  focusing primarily on the dose-response assessment.  In addition to describing the
basic principles of carcinogenic  risk assessment, the  report describes examples of risk assessment work
done by EPA and four State/local agencies.

The Risk Assessment Guidelines of  1986. EPA 600/8-87-045.  Environmental Protection Agency, Office of
Health and Environmental Assessment, Washington, DC: 1987.
Center for Environmental Research  Information
U.S. EPA
26 West Martin Luther King Drive
Cincinnati, OH 45268
513-684-7562
FTS 684-7562
NTIS PB88-123997/AS                           $19.00

On September 24, 1986, the EPA issued risk assessment guidelines relating to five areas: carcinogenicity,
mutagenicity, chemical mixtures, suspect developmental toxicants, and estimating exposures (51 FR 33992-
34054). The guidelines were developed to promote high technical quality and Agency-wide consistency in
the risk assessment process. This document presents the five guidelines as they originally appeared in the
Federal Register but in a format  that is easier to read.
                                              63

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Risk Assessment. Management. Communication: A Guide to Selected Sources. Environmental Protection
Agency, Information Management and Services Division, Washington, DC: 1987.

National Technical Information Service
5285 Port Royal Road
Springfield, VA 22161
703-487-4650
FTS 737-4650
NTIS PB87 185500-XAB                          PC A10 $25.95 Original Publication
NTIS PB87 203402-XAB                          PC A06 $19.95 First Update
NTIS PB88-100102-XAD                          PC A04 $14.95 Second Update
NTIS PB88 128178-XAB                          PC A03 $12.95 Third Update

NOTE:    Original  publication and all updates must be purchased to have most current and complete
          directory information.  Contact NTIS for availability of future updates.


Risk Assessments:  Carcinoaenicitv. Mutaaenicitv, Teratoaenicitv. Reproductive Effects

Office of Health and Environmental Assessment (OHEA) (RD-689)
U.S. EPA
401 M Street, S.W.
Washington, DC 20460
202-260-7345
FTS 260-7345

Risk assessments are analyses of varying length and scope of scientific data on chemical substances as

these data relate to human health.  The documents are used  by EPA to determine whether a chemical

substance is carcinogenic, mutagenic, teratogenic, or affects human reproductive systems, and what risk

it poses to the public, particularly in relation to other chemicals. These  evaluations may be individual

documents or part  of a larger document (e.g., Health Assessment Documents).


Threshold Limit Values and Biological Exposure Indices.  American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH: 1988.

ACGIH
6500 Glenway Avenue, Building D-7
Cincinnati, OH  45211-4438
513-661-7881

The ACGIH publishes Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs). TLVs are based

on available information from industrial experience and from experimental human and animal studies.  The

BEIs are based on epidemiologicai and field study data or determined as bioequivalent to a TLV by means

of pharmacokinetic analysis of data from controlled human studies.
                                              64

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Toxicitv One-Liners

Office of Pesticide Programs/HED
U.S. EPA
401 M Street, S.W.
Washington, DC 20460
703-557-7351
Toxicity One-Liners summarize test results on toxicity required by Office of Pesticide Programs (OPP) from

the producers of pesticides who want to bring a new product on the market.  For each test submitted,
information is provided on the testing laboratory, the kind and length of study, the material tested, and the

date the study was finished.


User's Manual for the Human Exposure Model (HEM). EPA-450/5-86-001. Environmental Protection Agency,
Office of Air Quality Planning and Standards, Research Triangle Park, North Carolina: June 1986.

National Technical  Information Services
5285 Port Royal Road
Springfield, VA 22161
703-487-4650
FTS 737-4650

NTIS PB87-168399/A06                          $23.00
                                              65

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66

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                                             INDEX


This index may be used as a guide to locate EPA offices and services that provide information pertaining
to a specific key subject area (e.g., asbestos).  Reference numbers, which refer to the specific reference
number of the EPA offices and services listed in Sections I and II, are provided for each subject area listed
below.

Kev Subject Areas                                            Reference Number

Acid rain                                                     25, 25.1

Asbestos                                                     9, 18

Best Available Control Technology                              2, 10, 26.3.1, 26.3.2
(BACT)

Cancer                                                      4,20,26.3.3,29.1.2,34.1,
                                                             35.1.1

Carcinogen Risk Assessment                                   4, 26.3.3, 34.1

Chemical Toxicity                                             1, 4, 11, 22, 23, 24, 26.3.3,
                                                             29.1.2,30.2, 30.4, 34,
                                                             34.1, 34.3, 35.1

Clean Air Act                                                 9, 25, 26, 26.1, 26.2, 26.3,
                                                             27

Comprehensive Environmental Resource,                        3, 37, 37.1, 37.2, 37.3, 37.4
Compensation,  and Liability Act (CERCLA)

Control Technology                                           2.9, 26, 26.2.1, 26.3,
                                                             26.3.1,26.3.2, 30.1, 33.1,
                                                             37

Document Distribution                                         1, 2, 5, 6, 7, 15, 17, 19,
                                                             30.5, 32, 32.1, 38

Drinking Water                                                4, 17, 38.1, 34.3

Emergency Response -                                        3, 21. 22, 23, 28, 37, 37.3
Chemical Spills or Releases

Emergency Response - Poisoning                              21, 22, 24

EPA Programs                                                15. 38

Exposure Assessment                                         1,11, 26.3.3, 27.1, 29.1.1,
                                                             30.2,30.3,31,31.2,34.2,
                                                             37.2
                                               67

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Key Subject Areas

Fuels

Greenhouse Effect

Hazardous Waste


Health Effects - Human
Health Effects - Ecological

Hotlines


Indoor Air Pollution

Lowest Achievable Emission Rate
(LAER)

Mobile Sources

Monitoring



Motor Vehicles

Noncancer Risk Assessment


Permits

Pesticides


Poison Control Centers

Radiation

Radon

Reasonably Available Control
Technology (RACT)

Reproductive Effects
Reference Number

12, 14, 26.3.1, 27. 27.1

25.2

6,34.3,37, 37.1, 37.2,
37.3, 38, 38.1

4,  11, 22, 29.1.2, 30.2,
30.4,  34, 34.1, 34.3, 34.4,  35,  35.1,
35.1.1, 35.1.2, 35.1.3,  35.1.4, 35.1.5,
35.1.6, 37.2

30.4,33,33.1,34

1,  2, 3, 6, 9, 16, 17, 18,
21, 23, 24

25, 25.3, 28, 34.4

10


5,  12, 14, 27, 27.1
5,26, 26.1, 26.1.1, 26.1.2,
26.1.4, 28, 31, 31.1, 33.1
37.2

13,27, 27.1, 34.4

1, 4, 26.3.3, 29.1.2, 34,
34.1, 34.3,34.4, 36,

2, 5

17,22, 29, 29.1, 29.1.1,
29.1.2, 29.1.3, 35.1.2

24

23, 25, 28, 28.1, 28.2, 28.3

28.3

2
1, 29.1.2, 34, 34.1, 35.1,
35.1.1, 35.1.5
                                                68

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Kev Subject Areas                                             Reference Number

Resource, Conservation, and                                   6
Recovery Act (RCRA)

Right-To-Know                                                3

Risk Communication                                           1,16

Risk Reference Dose                                           4

Superfund                                                    3,6,23,37,37.1,37.2,
                                                             37.3,38,38.1,38.2

Title III                                                       3, 30.5, 37.4

Toxic Substances Control Act                                  7, 11, 30, 30.1, 30.2, 30.3,
                                                             30.4, 30.5, 30.6
(TSCA)

Transport and Fate                                            26.1.3, 26.3, 26.3.3, 28.1,
                                                             29.1.1, 30.2, 30.3, 31,
                                                             31.1, 31.2, 33, 33.1, 34.2

Underground Storage Tank  (UST)                               6
                                              69

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70

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               APPENDIX
Data Bases Containing Information Relevant to
   Health, Exposure, and Risk Assessment
               of Air Toxics
                   A-1

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A-2

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                                      INTRODUCTION


The computerized sources described in this section of the directory represent what is available today on the

subject of health, exposure, and risk assessment of air toxics. The reader should be aware, however, that

computerized sources of information change rapidly and new sources appear continuously.


This appendix describes the contents of (rather than evaluates) data bases containing information relevant
to health, exposure, and risk assessment of air toxics. Prices to access and retrieve data vary greatly from

vendor to vendor and from source to source. Some data bases are more user friendly than others. Some

are still available on-line, but are no longer being updated.


Vendors offer training and complete data base descriptions once an account with them is set up.

Vendors  through which these data bases are  available  are listed  after each data base and contact

information for each vendor is listed at the end of the appendix.


CHEMICAL PROPERTIES. HAZARD. AND TOXICITY-FACTUAL DATA  BASES

AGROCHEMICALS HANDBOOK (DIALOG)
Provides chemical,  physical, analytical, agricultural  use, toxicological, and environmental data  on 500 +
component active ingredients which are contained in agrochemical products used worldwide. Produced by
the Royal Society of Chemistry.

CHEMICAL CARCINOGENESIS RESEARCH INFORMATION SYSTEM (CIS, TOXNET)
Produced by Stanford Research Institute for National Cancer Institute.  Results of carcinogenicity (positive
or negative results), mutagenicity (positive only), tumor promotion (positive only), and cocarcinogenicity
tests (positive only).

CHEMICAL EVALUATION SEARCH  AND RETRIEVAL SYSTEM - CESARS  (CIS)
Sponsored by EPA Great Lakes Program and Michigan State Department  of Natural Resources.  Detailed,
evaluated, fully referenced profiles of 194+ chemicals. 185 data fields including acute and chronic toxicity,
carcinogenicity, teratogenicrty, physical/chemical properties, environmental fate, and environmental effects.
Last update to the data base was in 1985.

CLINICAL TOXICOLOGY OF COMMERCIAL PRODUCTS - CTCP (CIS)
Based upon printed version.  Compilation of common commercial product ingredients and their toxicities.
Contains information on toxicology, health effects, treatment of poisoning, manufacturing, production for
1,500+ ingredients of 22,000+ commercial products.

ENVIROFATE (CIS)
Gives information on the environmental fate or behavior of chemical substances as well as physical-chemical
properties. Sponsored by EPA Office of Toxic Substances. 8,000+ records  on 450+  chemicals.
                                            A-3

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EPA PESTICIDE FACT SHEETS (NPIRS)
Fact sheets prepared by the Environmental Protection Agency Office of Pesticide Programs; designed to
provide concise information about active ingredients used in pesticide products. Data and summarized
information in 13 sections including description of the chemical, lexicological, physiological, biochemical,
environmental, and ecological characteristics, tolerance assessment, problems with chemical, science
summary,  regulatory position and rationale, major data gaps and due dates, and EPA contact
person.  134+fact sheets available.

GENETOX (CIS)
Contains summary information on genetic assay studies conducted on 2,500+ compounds.   Includes
specific indications of type of assay performed, the biological host, type of endpoint measured,  and final
quantitative results.

HAZARDOUS SUBSTANCES DATA BANK - HSDB (TOXNET)
Detailed, scientifically reviewed, fully referenced profiles for 4,200 + chemicals. Records have up to 150 data
fields in 11 categories including Substance Identification, Manufacturing/Use Information, Chemical and
Physical Properties, Safety and  Handling, Toxicity/Biomedical Effects,  Pharmacology,  Environmental
Fate/Exposure Potential, Exposure Standards and Regulations, Monitoring and Analysis Methods, Additional
References, and Express Data (new data).  Produced by Specialized Information
Services of the National Library of Medicine.

HEILBRON (DIALOG)
75,000+ concise entries with information on 175,000+ chemicals. Includes chemical identification,  physical-
chemical properties, use, hazard and key reference data.

MERCK INDEX (BRS, DIALOG)
Full text of the tenth printed edition, updated to include 57 new and 341 substantially revised monographs.
10,000+ records.  Gives concise information on chemicals including discussions of isolation, preparation,
biosynthesis,  physical and biological properties, pharmacological actions, uses and toxicity.

REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES - RTECS (CIS, MEDLARS, TOXNET)
On-line interactive version of NIOSH publication.  Provides data for 90,000+ potentially toxic chemicals,
including toxicity data, chemical identifiers, exposure standards, NTP test status and status under various
Federal regulations and programs.  Data base also available on microfiche and on CD-ROM (SilverPlatter).

REPROTOX (Reproductive Toxicology Center)
Provides comprehensive information on the reproductive effects of hundreds of chemical substances.  Offers
summaries of most relevant and important articles.  Data base  use is included with membership in the
Reproductive Toxicology Center.

TERATOGENICITY-ENVIRONMENTAL TERATOLOGY INFORMATION CENTER DATA BASE  (MEDLARS)
Information from open literature on testing and evaluation for teratogenic activity of chemical, biological and
physical agents.  Subfile in TOXLJNE data base.

TOXIC INTERACTION DATA BASE
Internal  EPA  data base containing summary toxicity data from published laboratory studies  on toxic
interactions between chemicals.  The data include the exposure conditions and type of interaction, as well
as the statistical analysis methods used. Contact Dr. Richard Hertzberg at 513/569-7582.

TOXIC SUBSTANCES CONTROL ACT TEST SUBMISSIONS - TSCATS (CIS)
Indexes  unpublished health and safety studies, chemical test data, and substantial risk data submitted to
EPA under the Toxic Substances Control Act (TSCA). Includes 18,000+ records covering 2,700+ chemicals.

                                             A-4

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Catalogs the purpose of testing, test organism(s) used, route(s) of administration, and where available, a
description of the nature of the chemical tested.  Gives the title of the submission and file identification data.
Copies of studies available on microfiche from NTIS or CIS.  Developed by Syracuse Research Corporation
for the Office of Toxic Substances of EPA.
CHEMICAL PROPERTIES. HAZARD. AND TOXICITY-BIBLIOGRAPHIC DATA BASES

BIOSIS PREVIEWS - BIOLOGICAL ABSTRACTS (BRS, DIALOG, ORBIT, a segment in TOXLJNE)
Major comprehensive worldwide coverage of research in life sciences.  Extensive coverage of toxicology.
Covers 9,000 + primary journals as well as other literature. 5,100,000 + references from 1969 to the present.


CANCERLJT (BRS, DIALOG, MEDLARS)
Sponsored by National Cancer Institute;  produced by the National Library of Medicine. 3,000+ U.S. and
foreign journals, books, reports, and meeting abstracts reviewed for inclusion. 520,000 + references from
1963 to the present.

DOE ENERGY (DIALOG, ORBIT)
Provides comprehensive coverage of literature, patents, monographs, and technical reports concerning all
aspects of energy production, utilization, and conservation.  Information on toxicology related to energy
sources and byproducts.  Sponsored by the Department of Energy. 1,750,000+ records from 1974 to the
present.

ENVIROUNE (DIALOG, ORBIT)
Worldwide environmental information coverage of 5,000+ international primary and secondary source
publications.   Subject scope  includes fields such as management, technology, planning, law, political
science, economics, geology, biology, and chemistry as  they relate to environmental issues.  Literature
scanned includes periodicals, government documents, industry reports, meeting proceedings, newspaper
articles, films, and monographs. 120,000+ records from 1971 to the present.

ENVIRONMENTAL MUTAGEN INFORMATION CENTER - EMIC (MEDLARS)
Consists primarily of references from the open literature  that report the testing of chemicals, biological
agents and some physical agents for mutagenicity. It also includes general references and methods papers
on test systems and organisms. EMIC is a subfile of the TOXLJNE data base.

MEDUNE (BRS, DIALOG, MEDLARS)
Indexes articles from 3,200+ biomedical journals published in the U.S. and abroad.  MEDUNE is indexed
using NLM's controlled vocabulary, MESH (Medical Subject Headings) and contains all citations indexed
in Index Medicus.  It is a major source of biomedical literature.  5,200,000+ references from 1966 to
the present.

NIOSH TECHNICAL INFORMATION CENTER DATA BASE - NIOSHTIC (DIALOG, INFOLINE)
National Institute for Occupational Safety and Health Technical Information Center file.  Covers toxicology,
epidemiology, industrial hygiene practices and other areas of occupational health and safety. Citations from
400+ journals, NIOSH publications, including contract and grant reports, theses, monographs, and some
unpublished documents.  Contains  important articles from early literature, some dated pre-1900.  Also
available on OSH-ROM CD ROM.

NTIS (BRS, DIALOG, ORBIT)
Produced by National Technical Information Service.  Covers U.S. government-sponsored research  and
development for 200+ agencies. Includes technical reports, some reprints, federally-sponsored translations,

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and foreign language reports in areas of major technical interest.  1,200,000+ records from 1964 to the
present.

POLLUTION ABSTRACTS (BRS, DIALOG)
Covers all  aspects  of pollution, solid waste management and  environmental quality.   Produced by
Cambridge Scientific Abstracts, Bethesda, Maryland. 124,000+ records from 1970 to the present.

TOXUNE - TOXICOLOGY INFORMATION On-line (MEDLARS)
Specifically designed to offer comprehensive bibliographic coverage of toxicology information.  Covers the
pharmacological, biochemical, physiological, environmental, and  toxicologies! effects of chemicals and
drugs.  Fourteen subfiles including Toxicity Bibliography (TOXBIB) from MEDLINE, Chemical-Biological
Activities  (CBAC) from Chemical Abstracts, Toxicoiogical Aspects  of Environmental Health (BIOSIS) from
Biological Abstracts, Pesticides Abstracts (PESTAB), International Pharmaceutical Abstracts (IPA), NIOSHTIC
(NIOSH), Toxicology Research Projects from the  NIH Computer Retrieval of  Information on Scientific
Projects data base (CRISP), Toxicology Document and Data Depository (NTIS) from NTIS, Hazardous
Materials Technical Center of Defense Logistics Agency (HMTC), Environmental Mutagen and Environmental
Teratology Information Centers (EMIC and ETIC), International Labour Office CIS Abstracts (CIS), Aneuploidy
(ANEUPL), and Epidemiology Information System (EPIDEM) of FDA. Produced by Specialized Information
Services of the National Library of Medicine.  2,000,000+ references.


RISK ASSESSMENT

HAZARDOUS WASTE COLLECTION (EPA)
Data base  of information sources on subject of hazardous waste.  Includes references to books, key
journals,  EPA reports and data bases. Operates on IBM XT/AT  compatibles and requires dBASE ll/lll
software. Created by EPA Headquarters Library. Available for purchase through NTIS (PB87-152690).

INTEGRATED RISK INFORMATION SYSTEM - IRIS  (PHNET - pending)
EPA data base of chemical-specific risk information on 365 chemicals with  new files added every month.
Gives verified reference dose summaries  and verified carcinogen assessments, drinking water health
advisories and summaries of EPA regulations. Available through the Public Health Network (PHNET), to be
available through National Library of Medicine's TOXNET.  Contact IRIS Users Support 513/569-7254.

STUDIES ON TOXICITY APPLICABLE TO RISK ASSESSMENT -  STARA  (EPA NCC-IBM  System 3090
Mainframe)
EPA data base of quantitative toxicity data at the dose group level  compiled  from  world  scientific
publications. The associated programs allow easy access to chemical-specific toxicity data, convert the raw
data into common dose units of mg/kg/day, and provide graphs of the data as dose versus duration versus
toxic severity. Available from TSSMS Office 919/541-3629.


AIR TOXICS

NATIONAL AIR TOXICS INFORMATION CLEARINGHOUSE DATA BASE - NATICH (NATICH - EPA)
In-house  data base of the EPA National Air Toxics Information Clearinghouse.  Contains information
collected from Federal, State, and local agencies,  as well as research information from EPA and  other
organizations. Information collected from air pollution control agencies is organized according to agency,
pollutant, and emission source, and includes the following:  regulatory program descriptions and contacts;
permitting data; acceptable ambient concentrations; ambient air monitoring  information; source test data;
emissions inventory data; and research and development information. In addition selected  preliminary EPA
risk assessment information is included in  NATICH.  Research information is presented in two categories:

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descriptions of ongoing research and regulatory development projects, and bibliographic citations/abstracts
for published documents. NATICH is available to government agencies for direct access (Contact 919-541 -
0850/FTS 629-0850) and to the public through NTIS (Contact 703-487-4807).


EMERGENCY RESPONSE

CHEMICAL HAZARD RESPONSE INFORMATION SYSTEM - CHRIS  (CIS)
Contains emergency response and chemical handling information for 1,016 chemical substances.  The fields
of information covered in CHRIS include physical and chemical properties, health hazards, fire hazards,
chemical reactivity, water pollution, shipping and labelling requirements, Coast Guard hazard assessment
codes and classifications, and response and first aid information. Also available on CD-ROM (SilverPlatter)
and in a microcomputer version on floppy disks (from CIS).

CHEMTREC HAZARD INFORMATION TRANSMISSION - HITS (CMA)
Chemical profiles giving emergency response information which represents an in-house synthesis of
information from reference materials and MSDS's submitted by CHEMTREC members from industry. Users
cannot search the data base, rather, specific information is downloaded to the user by HITS staff. Use of
the data base requires pre-registration approval from CMA. Registration is limited to fire services, police and
sheriff's departments, emergency  medical services and other groups which respond to  chemical
emergencies.  Operated by the Chemical Manufacturers Association.

HAZARDLINE (OHS,  BRS)
Provides emergency response,  safety, regulatory, and health  information on  4,000+ chemicals.  Data
element for special bulletins for news/current awareness on chemicals.  Handbook format; user friendly,
menu driven system (on OHS).  Produced by Occupational Health Services.


PUBLICATIONS INFORMATION

CURRENT CONTENTS SEARCH (BRS)
On-line version of the Institute for Scientific Information's Current Contents. Provides the tables of contents
of current journals in the  sciences and other subject areas and gives bibliographic information for each item
listed.

GPO MONTHLY CATALOG (BRS, DIALOG)
Corresponds to printed Monthly Catalog of United States Government Publications.  References reports,
studies, fact sheets, maps, handbooks, conference proceedings, etc., issued by all U.S. agencies, including
Congress.  Also included are records of all Senate and House hearings on private and public bills and laws.


REGULATORY INFORMATION

CHEMICAL ACTIVITY STATUS REPORT - CASR (CIS)
Lists chemicals that  EPA is  studying  or has studied in the course of regulatory or scientific research
activities.  Includes 19,000+ records covering 8,000+  unique chemicals. Summaries of EPA activities and
contacts included.

CHEMICAL REGULATIONS AND GUIDELINES SYSTEM - CRGS (DIALOG)
Indexes U.S. federal  regulatory material relating to the control  of chemical substances,  covering federal
statutes, promulgated regulations, and available federal guidelines, standards, and support  documents.
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Indexed by chemical name and CAS registry number.  Sponsored  by the U.S. Interagency Regulatory
Liaison Group. 4,500+ records on regulations in effect since June 1982.

NATIONAL PESTICIDE INFORMATION RETRIEVAL SYSTEM - NPIRS (NPIRS)
Includes 50,000+ pesticide products registered by EPA and registrations of several states.   For each
federally-registered product provides: Product name(s), registrant name and address, EPA registration
number, type(s) of formulation and pesticidal activity, active ingredient name(s) and percentage(s), site(s)
and crop(s), pest(s) for each site or crop.  Includes Report from OPP, the newsletter of the EPA Office of
Pesticide program. Soon to include EPA's Pesticide Data Management System Data base which will include
information on 160,000+ different scientific studies and related documents submitted to EPA by companies
seeking pesticide product registration.
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CONTACT INFORMATION FOR ESTABLISHING On-line SYSTEMS ACCESS
  BRS/BRS COLLEAGUE
  BRS Information Service
  8000 Westpark Drive
  McLean, VA 22102
  800-955-0906

  CHEMICAL INFORMATION SYSTEM (CIS)
  CIS, Inc.
  Fein Marquart Associates
  7215 York Road
  Baltimore,  MD 21212
  800-247-8737

  CHEMTREC HITS (CMA)
  Chemical Manufacturers Assoc.
  2501 M Street, N.W.
  Washington, D.C.  20037
  202-887-1255

  DIALOG
  Dialog Information Services, Inc.
  Marketing  Dept.B
  3460 Hillview Avenue
  Palo Alto, CA  94304
  800-3DIALOG

  ORBIT Search Service
  Division of Maxwell On-Line, Inc.
  8000 Westpark Drive
  McLean, VA  22102
  800-456-7248

  MEDLARS
  MEDLARS Management Section
  National Library of Medicine
  Bldg. 38A, Rm 4N421
  Bethesda,  MD  20894
  800-638-8480

  NATICH
  Pollutant Assessment Branch, MD-13
  U.S. EPA
  Research Triangle Park, NC  27711
  919-541-0850/FTS 629-0850
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OHS-HAZARDUNE/EHN
Occupational Health Services, Inc.
W. 42nd Street, 12th Floor
New York, NY  10036
212-789-3535

REPROTOX
Reproductive Toxicology Center
2425 L Street, N.W.
Washington, D.C.  20037
202-293-5137

CERIS/NPIRS
Center for Environmental and Regulatory Information Systems/
National Pesticide Information Retrieval System
NPIRS User Services Specialist
1231 Cumberland Avenue
West Lafayette, IN  47906-1317
317-494-6614

TOXNET
National Library of Medicine
Specialized Information Services
Biomedical Files Implementation Branch
8600 Rockville Pike
Bethesda, MD  20894
301-496-6531
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