U.S. DEPARTMENT OF COMMERCE
                                National Technical Information Service
                                PB80-112170
Formulation  of a  Preliminary Assessment
of  Halogenated Organic Compounds in
Man  and  Environmental Media

Research Triangle Inst,  Research Triangle Park, NC
Prepared for

Environmental Protection Agency, Washington, DC Office of Toxic Substances

Jul 79

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PORTIONS OF THIS REPORT ARE NOT LEGIBLE,



HOWEVER, IT IS THE BEST REPRODUCTION



AVAILABLE FROM THE COPY SENT TO NTIS,

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                                    TECHNICAL REPORT DATA
                            (Please read Instructions on the reverse before completing)
1. REPORT NO.
 EPA-560/13-79-006
                                                              . RECIPIENT'S ACCESSION NO.
4 TITLE AND SUBTITLE
 FORMULATION OF  A.PRELIMINARY  ASSESSMENT OF HALOGENATED
 ORGANIC COMPOUNDS. IN MAN AND  ENVIRONMENTAL MEDIA.
                                                             5. REPORT DATE
                                                                  July. 1979
                                                             6. PERFORMING ORGANIZATION CODE
7. AUTHOR(S)
 E..DV Pellizzari,  M/ D. Erickson and R. A.  Zweidinger
                                                             8. PERFORMING ORGANIZATION REPORT NO.
9. PERFORMING ORGANIZATION NAME AND ADDRESS
 'Research  Triangle Institute
 ; P.  0. Box 12194
  Research  Triangle Park,  NC   27709
                                                             10. PROGRAM ELEMENT NO.
                                                             11. CONTRACT/GRANT NO.
                                                                 68-01-4731
12. SPONSORING AGENCY NAME AND ADDRESS
 Environmental Protection  Agency
 Office of  Toxic Substances
 Washington,  DC  20460
                                                             13. TYPE OF REPORT ANO PERIOD COVERED
                                                              Annual, Nov.  1976-Dec.  1978
                                                             14. SPONSORING AGENCY CODE
15. SUPPLEMENTARY NOTES
16. ABSTRACT
      This  comprehensive  report covers  the information which has' been gathered  on. this.
 program  during the past  year.  A model is developed  for making .a  comparative assess-
 ment of  halo genated prganics: in ^man^and environmental .media. .This/ comprehensive   , ,
 report punctuates- the -first .phase of  this program. -    .           .
T7;
                                 KEY WORDS AND DOCUMENT ANALYSIS
                  DESCRIPTORS
                                                b.lDENTlFIERS/OPEN ENDED TERMS
                                                                            C. COSATI Field/Group
 Preliminary Survey     .
, Halogenated Hydrocarbons
          ""
           .
 •Water .          ;
 Food...          ;
 :Tissue.   • .'  •'    :
 Five Area -Study
13. DISTRIBUTE ON STATEMENT

 Release  to"' Public
                                                19. SECURITY CLASS (This Report!
                                                  .Unclassified-.  .  . -
                                                                            21.
                                                20. SECURITY CLASS (This page)
                                                •  Unclassified.
                                                                            22. PRICE
    Form 2220—1 (R«y. 4—77)   f=ReviOUS EDITION IS OBSOLETE.
                                                    /

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         FORMULATION OF A PRELIMINARY ASSESSMENT OF
          HALOGENATED ORGANIC COMPOUNDS IN MAN AND
                     ENVIRONMENTAL MEDIA
                             by


Edo D. Pellizzari, Mitchell D. Erickson and R. A. Zweidinger


                   Contract No. 68-01-4731
                       Project Officer

                      Dr. Joseph Breen
                 Office of Toxic Substances
                    Washington, DC  20460
            U. S. ENVIRONMENTAL PROTECTION AGENCY
                 OFFICE OF TOXIC SUBSTANCES
                    WASHINGTON, DC  20460
                                I, CU

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                                 DISCLAIMER

     This report has been reviewed by the Surveillience and Analysis Division
of the Office of Toxic Substances, U. S.  Environmental Protection Agency,
and approved for publication.   Approval does not signify that the contents
necessarily reflect the views  and policies of the U.  S. Environmental Protec-
tion Agency, nor does mention  of trade names or commercial products constitute
endorsement or recommendation  for use.
                                       ii

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                                  ABSTRACT

     This comprehensive report covers the information which has been gathered
on this program during the past year.  A model is developed for making a
comparative assessment of halogenated organics in man and environmental
media.   This comprehensive report punctuates the first phase of this program.
                                      •ill

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IV

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                                CONTENTS

Abstract	iii
Figures	   vi
Tables	   xi
Acknowledgment	xxi

     1.   Conclusions  	    1
     2.   Recommendations  	    2
     3.   Program Objectives	    3
     4.   Introduction	    4
     5.   Incidence of Cancer in The Study Areas	    9
     6.   Potential Sources of Halogenated Hydrocarbons 	   27
     7.   Measurement" of Halogenated Hydrocarbons in The Environment.   38
     8.   Mutagenic/Carcinogenic Activity of Halogenated Compounds.  .   89
     9.   Biological Chemistry of Halogenated Hydrocarbons	   95
    10.   Demographic and Meteorological Characteristics of Several
               Potential Study Sites	109
    11.   Sites and Halogenated Hydrocarbons Selected for a Compara-
               tive Analysis Between Man and the Environment	118
Appendices
     A	142
     B    Metabolism Summaries	278
     C    Wind Roses for Study Sites	412
     D    Population Density for Potential Study Sites	422
                                                      Preceding page blank

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                                FIGURES
Number                                                                 £i£
 4-1      Schematic  flow  diagram demonstrating  interlocking  rela-
               tionships  between environment, man  and  association
               with  incidence  of cancer	    5
 4-2      Pertinent  relationships between discharge  sources,  environ-
               mental  media  and man	    7
10-1      Aerial photograph  (black and white  copy  of color print)  of
               Allied  North  and surrounding area,  Baton  Rouge,  LA.  .  .  Ill
10-2      Reproduction of transparent overlay for  Figure 10-1 showing
               rough outlines  of plant  sites	112
10-3      Infrared aerial photograph  (black and white  copy of .-?lor
               print)  of  Allied North, Allied South, Ethyl,  and
               surrounding area, Baton Rouge, LA  	  113
10-4      Reproduction of transparent overlay for  Figure 10-3 showing
               rough outlines  of plant  sites  and other major features.  114
 A-l      Map  of Buffalo  and Niagara Falls, NY  Area	143
 A-2      Map  depicting sampling locations 1  to 13 in  Niagara Falls,
               NY,	144
 A-3      Map  of "Old  Love"  Canal area of Niagara  Falls, NY  - sampling
               locations  for body-burden study  	  158
 A-4      Sampling locations and plant identifications for Site No.
               2, Niagara Falls, NY	165
 A-5      Sampling locations and plant identifications at Site No.  3,
               Buffalo, NY	'167
 A-6      GC/MS  profile of vapor-phase organics in ambient air in
               Niagara Falls, NY (P4/L7)	168
 A-7      GC/MS  profile of vapor-phase organics in ambient air in
               Niagara Falls, NY (P4/L8) 	  169
                                   VI

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                             FIGURES CONT'D.
Number                                                                Page
 A-8      GC/MS profile of vapor-phase organics in ambient air in
               Buffalo, NY (P4/L2)	170
 A-9      GC/MS profile of vapor-phase organics in ambient air from
               Buffalo, NY (P4/L3)	171
A-10      GC/MS profile of vapor-phase organics in ambient air from
               Buffalo, NY (P4/L4)	172
A-ll      Northern New Jersey, showing general sampling sites, Trip
               2  (September, 1978)	187
A-12      Map of Bound Brook, NJ showing site No. 1 and the sampling
               locations	188
A-13      Map of Rahway, NJ area showing site No. 2 and the sampling
               locations	189
A-14      Map of Hillside, NJ area, showing Flash Dry Cleaners (FDC)
               and sampling locations  	  190
A-15      Map of Edison, NJ area showing site No. 3 and sampling
               locations	191
A-16      Map of Fords, NJ area showing site No. 4 and sampling
               locations	192
A-17      Map of Rutherford, NJ area showing site no. 5 and sampling
               locations	193
A-18      GC/MS/COMP profile of vapor-phase- organics in ambient air
               at site No. 1 in Bound Brook, NJ (PI/LI)	200
A-19      GC/MS/COMP profile of vapor-phase organics in ambient air
               at site No. 1 in Bound Brook, NJ (P2/L4)	201
A-20      GC/MS/COMP profile of vapor-phase organics in ambient air
               at site No. 2 in Rahway, NJ  (P3/L7)	202
A-21      GC/MS/COMP profile of vapor-phase organics in ambient air
               at site No. 2 in Rahway, NJ  (P4/L2)	203
A-22      GC/MS/COMP profile of vapor-phase organics in ambient air
               at site No. 2 in Rahway, NJ  (P3/L3)	204
A-23      GC/MS/COMP profile of vapor-phase organics in ambient air
               at site No. 3 in Edison, NJ  (P6/L5)	205
                                    VII

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                             FIGERES  CONT'D.
Number                                                                ^^
A-24      GC/MS/COMP profile  of  vapor-phase organics in ambient air
               at site No.  4  in  Edison,  NJ (P6/L6)	206
A-25      GC/MS/COMP profile  of  vapor-phase organics in ambient air
               at site No.  4  in  Fords,  NJ (P8/L1)	207
A-26      GC/MS/COMP profile  of  vapor-phase organics in ambient air
               at site No.  4  in  Fords,  NJ (P9/L3)	208
A-27      GC/MS/COMP profile  of  vapor-phase organics in ambient air
               at site No.  5  in  Carlstadt, NJ (P10/L7)	209
A-28      GC/MS/COMP profile  of  vapor-phase organics in ambient air
               at site No.  5  in  Carlstadt, NJ (P11/L4)	210
A-29      Sampling locations  surrounding Kin-Buc Lanfill, Edison, NJ.  244
A-30      Map depicting sampling locations near industrial complex
               in Iberville Parish, LA	  247
A-31      Map depicting sampling locations of ambient air samp"1 \ng
               network in Iberville Parish, LA	  248
A-32      Sampling site and locations in Geismar,  LA area	252
A-33      Sampling site and location for Baton Rouge, LA area  ....  257
A-34      Sampling site and locations in Baton Rouge, LA	258
A-35      Sampling locations  for Deer Park and Pasadena, TX sites .   .  274
A-36      Sampling locations  in Freeport, TX (Dow 'A')	275
A-37      Sampling site and locations in La Porte, TX (E. I. DuPont
               deNemours & Co)	276
 C-l      Wind rose for Baton Rouge, LA	413
 C-2      Wind rose for Newark,  NJ	414
 C-3      Wind rose for McGuire, AFB, Writestown,  NJ	415
 C-4      Wind rose for Buffalo, NY	416
 C-5      Wind rose for Greensboro, NC.	      4^7
 C-6      Wind rose for Winston-Salem, NC	          ATO
 C-7      Wind rose for Houston (Ellington AFB), TX	    419
 C-8      Wind rose for Houston Intercontinental,  TX	        420
 C-9      Wind rose for Houston (Hobby), TX	
                                  Vlll

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                             FIGURES CONT'D.
Number                                                                Page
 D-l      Population, density map for the area surrounding Allied
               North, Baton Rouge, LA	 423
 D-2      Population density map for the area surrounding Allied
               South, Baton Rouge, LA	424
 D-3      Population density map for the area surrounding Ethyl
               Corp., Baton Rouge, LA	425
 D-4      Population density map for the area surrounding Dow Chemical
               Plaquemine, LA	426
 D-5      Population density map for the area surrounding Hercules,
               Inc. , Plaquemine, LA	427
 D-6      Population density map for the area surrounding Ciba-Geigy,
               St.  Gabriel, LA	428
 D-7      Population density map for the area surrounding White
               Chemical Co., Bayonne, NJ	429
 D-8      Population density map for the area surrounding Givaudan
               Corp., Clifton, NJ	 430
 D-9      Population density map for the area surrounding GAP Co.,
               Linden, NJ	431
D-10      Population density map for the area surrounding Prentiss
               Drug and Chem. Co., Newark, NJ	432
D-ll      Population density map for the area surrounding Troy Chem.
               Co., Newark, NJ	433
D-12      Population density map for the area surrounding Standard
               Chlorine Chem. Co., Kearney, NJ  	 434
D-13      Population density map for the area surrounding UOP, East
               Rutherford, NJ	435
D-14      Census tract map for the portion of Niagara Falls, NY, sur-
               rouding "Old Love" Canal	436
D-15      Population density map for the area surrounding Petrotex,
               Houston, TX ..... 	 437
D-16      Population density map for the area surrounding Ethyl Corp.,
               Pasadena, TX	439
                                    IX

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                             FIGURES CONT'D.
Number
D-17      Population density map for the area surrounding Gulf
               Chemical,  Texas City, TX	440
D-18-      Population density map for the area surrounding Union Car-
               bide, Texas City, TX	441
D-19      Population density map for the area surrounding DuPont,
               LaPorte,  TX	442
D-20      Population density map for the area surrounding Upjohn,
               LaPorte,  TX	443
D-21      Population density map for the area surrounding Diamond
               Shamrock,  Deer Park, TX	444
D-22      Population density map for the area surrounding Rollins
               Environmental, Deer Park,  TX	445
D-23      Population density map for the area surrounding Shell Co.,
               Deer Park,  TX	446

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                                 TABLES
Number                                                                Page
 5-1      US Average Cancer Mortality	   10
 5-2      Cancer Mortality for Baton Rouge Study Area	   11
 5-3      Cancer Mortality for Northeast New Jersey Study Area
               1950-1969	   15
 5-4      Cancer Mortality for the Buffalo-Niagara, NY Study Area.  .   21
 5-5      Cancer Mortality for Greensboro, NC Study Area 	   24
 5-6      Cancer Mortality for the Houston, TX Study Area	   25
 6-1      Halogenated Hydrocarbon Manufacturing Locations Identified
               for Population Density Mapping--Northern New Jersey
               Area	   28
 6-2      Halogenated Hydrocarbon Manufacturing Locations Identified
               for Population Density Mapping—Baton Rouge Area.  .  .   31
 6-3      Halogenated Hydrocarbon Manufacturing Locations Identified
               for Population Density Mapping--Buffalo/Niagara Area.   32
 6-4      Halogenated Hydrocarbon Manufacturing Locations Identified
               for Population Density Mapping—Houston Area	   34
 7-1      Levels of Halogenated Organic Compounds Found in Food in
               •the United States .  •	   39
 7-2      Levels of Halogenated Organic Compounds in Human Serum,
               Plasma and Blood in the United States	   44
 7-3      Levels of Halogenated Organic Compounds in Human Milk
               in the United States	   47
 7-4      Levels of Halogenated Organic Compounds in Human Tissue in
               the United States	   50
 7-5      Summary of Estimated Levels of Vapor-Phase Halogenated
               Organics in Ambient Air in Niagara Falls, NY	   55
 7-6      Summary of Estimated Levels of Purgeable Halogenated
               Organics in Drinking Water from Niagara and Buffalo, NY 57
                                    XI

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                             TABLES CONT'D.
 Number                                                                Page
  7-7       Levels  of Halogenated Organics Found in Water  in  the
                Buffalo/Niagara Area	58
  7-8       Summary of Estimated Levels of Halogenated Organics in
                Human Breath in Niagara Falls, NY	61
  7-9       Summary of Estimated Levels of Purgeable Organics in Human
                Blood Samples in Niagara Falls, NY	63
 7-10       Halogenated Extractable (Semi-Volatiles) in Human Blood.  .  .  64
 7-11       Summary of Estimated Levels of Purgeable Halogenated
                Organics in Human Urine from Niagara Falls, NY	65
 7-12       Summary of Estimated Levels of Vapor-Phase Halogenated
                Organics in the•New Jersey Area	•	66- •
 7-13       Summary of Estimated Levels of Purgeable Halogenated Organics
                in New Jersey Drinking Water	67
 7-14       Levels  of Halogenated Organics Found in Water  in the 'Tew
                Jersey Area	68
 7-15       Quantitative Analysis of Extractable Semi-Volatile HHC's
                in Tap Water in Northern New Jersey	  71
 7-16       Summary of Estimated Levels of Vapor-Phase Halogenated
                Organics in Baton Rouge, LA Area	72
 7-17       Summary of Purgeable Halogenated Hydrocarbon Levels Found
                at  Jefferson Parish Water Plant, 2/7/77-8/5/77	73
 7-18       Summary  of Purgeable Halogenated Hydrocarbon Levels Found
                in  Tap Water in Jefferson Parish	74
 7-19      Levels  of Halogenated Organics Found in Water  in the New
               Orleans/Baton Rouge Area	75
 7-20      Summary of Estimated Levels of Vapor-Phase Halogenated
               Organics  in Ambient Air in Baton Rouge, LA and Vicinity  79
7-21      Levels of Halogenated  Organics Found in Water  in the
               Houston Area	          g-^
7-22      Halogenated Hydrocarbons Detected in Ten Expired Air Samples
               From Male Volunteers  at Brooks AFB,  TX	83
                                   Xll

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                             TABLES CONT'D.
Number                                                                Pag
 8-1      Summary of Mutagenicity and Carcinogenicity Data on
               Halogenated Compounds	90
 9-1      CEA litres in Healthy Non-Smoking Subjects	98
 9-2      CEA litres in Healthy Subjects - Smokers, Non-Smokers and
               Pregnant Females 	  99
 9-3      CEA litres in Patients with Clinically Suspected Malignant
               Disease	100
 9-4      CEA litres in 3340 Patients with Non-Malignant Disorders.  . 101
 9-5      Comparison of RIA Methods for CEA	103
 9-6      Urinary CEA Levels in Healthy Subjects and Several Disor-
               ders 	104
 9-7      Plasma CEA Levels in the "Old Love" Canal Study	107
10-1      Water Companies Serving the Sampling Sites in New Jersey.  . 115
11-1      Prevalent Halogenated Compounds in Ambient Air and Water
               of Niagara Falls and Buffalo, NY	119
11-2      Prevalent Halogenated Compounds in Ambient Air and Water
               of Rahway/Woodbridge, Boundbrook and Passaic, NJ .   .  . 120
11-3      Prevalent Halogenated Compounds Occurring in Ambient Air
               and Water of Baton Rouge, Geismar and Plaquemine, LA  . 121
11-4      Prevalent Halogenated Compounds Occurring in Ambient Air
               and Water of Houston, Deer Park and Pasadena, TX .   .  . 122
11-5      Ranking of Pesticides and PCB's by Reported Concentrations
11-6      Total Potential 24 Hr Dose of Halogenated Compounds to
               Humans from Air and Water in Niagara Falls and Buffalo,
               NY	125
11-7      Total Potential 24 Hr Dose of Halogenated Compounds to
               Humans from Air and Water in Rahway/Woodbridge,
               Boundbrook, and Passaic, NJ	 126
11-8      Total Potential 24 Hr Dose of Halogenated Compounds to
               Humans from Air and Water in Baton Rouge, Geismar
               and Plaquemine, LA	127
                                   XI11

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                             TABLES CONT'D.
Number
11-9      Total Potential 24 Hr Dose of Halogenated Compounds to
               Humans from Air and Water in  Houston,  Deer Park,
                                                                       128
               and Pasadena, TX	
11-10     Halogenated Compounds Selected for Monitoring in Air and
               Water in Niagara Falls and Buffalo,  NY	    131
11-11     Halogenated Compounds Selected for Monitoring in Human
               Samples from Niagara Falls and Buffalo,  NY	    132
11-12     Halogenated Compounds Selected for Monitoring in Air and
               Water in Rahway/Woodbridge, Boundbrook and Passaic, NJ  133
11-13     Halogenated Compounds Selected for Monitoring in Human
               Samples from Rahway/Woodbridge,  Boundbrook and
               Passaic,  NJ	    134
11-14     Halogenated Compounds Selected for Monitoring in Air and
               Water in Baton Rouge,  Geismar and Plaquemine,  1*   . .    136
11-15     Halogenated Compounds Selected for Monitoring in Human
               Samples from Baton Rouge,  Geismar and  Plaquemine, LA.    137
11-16     Halogenated Compounds Selected for Monitoring in Air and
               Water in Houston,  Deer Park and  Pasadena,  TX	    138
11-17     Halogenated Compounds Selected for Monitoring in Human
               Samples from Houston,  Deer Park  and  Pasadena,  TX. . .    139
11-18     Pesticides and PCB's Selected for  Correlative Studies  in
               Biological Tissue  and  Soil Samples for All Geographi-
               cal  Areas	    140
 A-l      Sampling  Protocol for Vapor-Phase  Organics  in Air from
               Household Basements  and School Rooms in Niagara,  NY .    145
 A-2      Sampling  Protocol for Collection of Semi-Volatile Organics
               on Polyurethane Foam from Air in Household Basements
               in Niagara,  NY	    j_47
 A-3      Estimated Levels  of  Vapor-Phase Halogenated Organic Vapors
               in Air  of Household  Basements and School Room in
               Niagara,  NY	    148
                                    xiv

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                              TABLES CONT'D.
Number                                                                Page
 A-4      Semi-Volatile Organic Chemicals Identified in Air from
               Household Basement  (LI), Niagara, NY Using PUT
               Technique	151
 A-5      Semi-Volatile Organic Chemicals Identified in Air from
               Household Basements  (L3), Niagara, NY Using PUT
               Technique	152
 A-6      Semi-Volatile Organic Chemicals Identified in Air from
               Household Basement  (L5), Niagara, NY Using PUT
               Collection Technique  	  153
 A-7      Semi-Volatile Organic Chemicals Identified in Air From
               Household Basement  (L6), Niagara, NY Using PUT Collec-
               tion Technique	154
 A-8      Semi-Volatile Organic Chemicals Identified in Air from
               Household Basement  (L4), Niagara, NY Using PUF Collec-
               tion Technique	155
 A-9      Semi-Volatile Organic Chemicals Identified in Air from
               Household Basement  (L2), Niagara, NY Using PUF Collec-
               tion Technique	156
A-10      Air Exposure Monitoring  Protocol for the "Old Love" Canal
               Area of Niagara Falls, NY	158
A-ll      Meteorology for July 6 and 7, 1978 in the "Old Love" Canal
               Area of Niagara Falls, NY	159
A-12      Estimated Levels of Vapor-Phase Halogenated Compounds in
               Air Inside Homes of  "Old Love" Canal Area of Niagara
               Falls, NY	160
A-13      Estimated Levels of Vapor-Phase Halogenated Compounds in
               Ambient Air Outside Homes of "Old Love" Canal,
               Niagara, NY	162
A-14      Sampling Protocol for Site No. 2, Niagara Falls, NY - Trip 1 164
A-15      Sampling Protocol for Site No. 3, Buffalo, NY - Trip 1.  .  .  166
A-16      Vapor-Phase Halogenated Organics Identified in Niagara
               Falls, NY (P4/L7)	173
                                    xv

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                              TABLES CONT'D.
 Number
 A-17       Vapor-Phase Halogenated Organics Identified in Niagara
                Falls, NY  (P4/L8)	
 A-18       Vapor-Phase Halogenated Organics In Ambient Air in
                Buffalo, NY  (P4/L2)	174
 A-19       Vapor-Phase Halogenated Organics in Ambient Air from
                Buffalo, NY  (P4/L3)	174
 A-20       Vapor-Phase Halogenated Organics in Ambient Air from
                Buffalo, NY  (P4/L4)	17$
 A-21       Estimated Levels  of Site-Specific Vapor-Phase Halogenated
                Compounds  in Ambient Air in Niagara Falls, NY	176
 A-22       Estimated Levels  of Purgeable Halogenated Compounds in
                Drinking Water from "Old Love" Canal in Niagara Falls,
                NY	   177
 A-23       Estimated Levels  of Purgeable Halo.genated Compounds -'n
                Drinking Water from "Old Love" Canal in Niagara
                Falls, NY	178
 A-24       Estimated Levels  of Purgeable Halogenated Compounds in
                Drinking Water Samples from Niagara Falls/Buffalo, NY
                Area '	179
 A-25       Quantitative Analysis of Extractable (Semi-Volatile) HHC's
                in Tap Water in Buffalo/Niagara	181
 A-26       Body  Burden Sampling Protocol for the "Old Love" Canal Area
                of Niagara Falls, NY	182
 A-27       Estimated Levels of Halogenated Compounds in Human Breath
                from "Old Love" Canal in Niagara Falls, NY	183
 A-28       Estimated Levels of Purgeable Halogenated Compounds in
               Human Blood Samples from "Old Love" Canal in Niagara
               Falls,  NY	184
A-29      Estimated Levels of Purgeable Halogenated Compound? in Human
               Urine Samples from "Old Love" Canal, In Niagara, NY.  .   185
A-30      Estimated Levels of Purgeable Halogenated Compounds in Human
               Urine Samples from "Old Love" Canal in Niagara Falls,
               NY	186
                                   xvi

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                             TABLES CONT'D.
Number                                                                Page
A-31      Sampling Protocol for Site No. 1, Bound Brook, NJ -
               Trip 2	   194
A-32      Sampling Protocol for Site No. 2, Rahway, NJ - Trip 2. .   .   195
A-33      Sampling Protocol for Site IDC (Flash Dry Cleaners),
               Hillside, NJ - Trip 2	   196
A-34      Sampling Protocol for Site No. 3, Edison, NJ - Trip 2. .   .   197
A-35      Sampling Protocol for Site No. 4, Fords, NJ - Trip 2  ...   198
A-36      Sampling Protocol for Site No. 5, Carlstadt, NJ - Trip 2  .   199
A-37      Vapor-Phase Halogenated Organics Identified in Ambient
               Air at Site No. 1 in Bound Brook, NJ (P2/L4)	   211
A-38      Vapor-Phase Halogenated Organics in Ambient Air at Site
               No. 1 in Bound Brook, NJ (PI/LI)	   211
A-39      Vapor-Phase Halogenated Organics Identified in Ambient Air
               at Site No. 5 in Rahway, NJ (P3/L7) - Trip 2	   212
A-40      Vapor-Phase Halogenated Organics Identified in Ambient Air
               at Site No. 2 in Rahway, NJ (P4/L2)	   212
A-41      Vapor-Phase Halogenated Organics Identified in Ambient Air
               at Site No. 2 in Rahway, NJ (P3/L3)	   213
A-42      Vapor-Phase Halogenated Organics Identified in Ambient Air
               at Site No. 3 in Edison, NJ (P6/L5)	   214
A-43      Vapor-Phase Halogenated Organics Identified in Ambient Air
               at Site No. 4 in Edison, NJ (P6/L6)	   214
A-44      Vapor-Phase Halogenated Organics Identified in Ambient Air
               at Site No. 4 in Fords, NJ (P8/L1) - Trip 2 	   215
A-45      Vapor-Phase Halogenated Organics Identified in Ambient Air
               at Site No. 4 in Fords, NJ (P9/L3)	   215
A-46      Vapor-Phase Halogenated Organics Identified in Ambient Air
               at Site No. 5 in Carlstadt, NJ (P10/L7)	   216
A-47      Vapor-Phase Halogenated Organics Identified in Ambient Air
               at Site No. 5 in Carlstadt, NJ (P11/L4)	   216
A-48      Estimated Levels of Vapor-Phase Halogenated Hydrocarbons
               in Ambient Air at Site No. 1 in Bound Brook, NJ
               (9/18 - 19/78)	   217

                                   xvii

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                              TABLES  CONT'D.
 Number
 A-49 '     Estimated Levels  of Vapor-Phase Halogenated Hydrocarbons
                in Ambient Air at  Site No. 1 in Bound Brook, NJ
                                                                        01 O
                (9/19-20/78)	
 A-50      Estimated Levels  of Vapor-Phase Halogenated Hydrocarbons
                in Ambient Air at  Site No. 2 in Rahway, NJ  (9/20-
                21/78)	    219
 A-51      Estimated Levels  of Vapor-Phase Halogenated Hydrocarbons
                in Ambient Air at  Site No. 2 in Rahwaya, NJ  (9/21-
                22/78)	    22°
 A-52      Estimated Levels  of Vapor-Phase Halogenated Hydrocarbons
                in Ambient Air at  Site No. 3 in Edison, NJ  (9/22-
                23/78)	    221
 A-53      Estimated Levels  of Vapor-Phase Halogenated Hydrocarbons
                in Ambient Air at  Site No. 3 in Edison, NJ  (9/2^-
                24/78)	    222
 A-54      Estimated Levels of Vapor-Phase Halogenated Hydrocarbons
                in Ambient Air at  Site No. 4 in Fords, NJ (9/25-
                26/78)	    223
 A-55      Estimated Levels of Vapor-Phase Halogenated Hydrocarbons
                in Ambient Air  at  Site No. 4 in Fords, NJ (9/26-
                27/78)	    224
 A-56      Estimated  Levels of  Vapor-Phase Halogenated Hydrocarbons
                in Ambient Air  at  Site No. 5 in Carlstadt, NJ  (9/28-
                29/78)	    225
 A-57       Estimated Levels of Vapor-Phase Halogenated Hydrocarbons
                in Ambient Air at Site No. 5 in Carlstadt, NJ  (9/29-
                3/78)	_	    226
A-58       Sampling Protocol for Central and Northern New Jersey.  .  .    227
A-59      Estimated Levels of Vapor-Phase Halogenated Organi-s in
               New Jersey	    228
A-60      Sampling Protocol for Kin-Buc Disposal Site	    229
                                   XVlll

-------
                             TABLES CONT'D.
Number                                                                Page
A-61      Estimated Levels of Vapor-Phase Halogenated Organics in
               Ambient Air from Kin-Buc Disposal Site., Edison, NJ
               (Periods 1 & 2)	    232
A-62      Estimated Levels of Vapor-Phase Halogenated Organics in
               Ambient Air from Kin-Buc Disposal Site, Edison, NJ
               (Periods 3 & 4)	    234
A-63      Estimated Levels of Vapor-Phase Halogenated Organics in
               Ambient Air from Kin-Buc Disposal Site, Edison, NJ
               (Periods 5 & 6)	    236
A-64      Ambient Air Sampling Protocol for Investigating Chemical
               Dump/Landfill in Edison, NJ	    238
A-65      Estimated Levels of Vapor-Phase Halogenated Organics in
               Ambient Air from Kin-Buc Disposal Site	    240
A-66      Estimated Levels of Purgeable Halogenated Hydrocarbons
               in Drinking Water from New Jersey	    241
A-67      Estimated Levels of Purgeable Halogenated Hydrocarbons
               in Drinking Water at Site No. 4 in Fords, NJ .  .  .   .    242
A-68      Estimated Levels of Purgeable Halogenated Hydrocarbons
               in Drinking Water at Site No. 5 in Carlstadt, NJ .   .    243
A-69      Ambient Air Sampling Protocol for Plaquemine, LA Area .   .    245
A-70      Concentrations of Vapor-Phase Halogenated Organics in
               Iberville Parish, LA 	    249
A-71      Concentrations of Vapor-Phase Halogenated Organics in
               Iberville Parish, LA 	    250
A-72      Ambient Air Sampling Protocol for Geismar, LA Area.  .  .   .    251
A-73      Estimated Levels of Vapor-Phase Halogenated Organics in
               Geismar, LA Area	   	    253
A-74      Ambient Air Sampling Protocol for Baton Rouge, LA Area.   .    254
A-75      Vapor-Phase Halogenated and Other Organics Estimated in
               Ambient Air of Baton Rouge, LA and Vicinity	    259
A-76      Minimum Total Halogenated Hydrocarbon Vapor in Ambient
               Air of Baton Rouge, LA	    260
                                    xix

-------
                             TABLES CONT'D.
Number                                                                Page
A~77      Ambient Air Sampling Protocol for Vapor-Phase Organics
               in Baton Rouge, LA	   261
A-78      Estimated Levels of Vapor-Phase Halogenated Organics in
               Ambient Air from Baton Rouge, LA	   262
A-79      Ambient Air Sampling Protocol for Houston, TX and
               Vicinity	   264
A-80      Ambient Air Levels of Vapor-Phase Halogenated Hydrocarbons
               in Houston, Pasadena, Deer Park, Freeport and LA
               Porte, TX Areas	   266
A-81      Estimated Minimum Total Ambient Air Levels of Vapor-Phase
               Organic Chemical Classes in Houston and Vicinities.  ..   268
A-82      Ambient Air Sampling Protocol for Vapor-Phase Organics
               in Houston, TX	   269
A-83      Estimated Levels of Vapor-Phase 'Halogenated Organics in
               Ambient Air from Houston, TX	   270
A-84      Ambient Air Sampling Protocol for Volatile Organics in
•  .    .        . Houston, TX	   272
A-85      Estimated Levels of Vapor-Phase Halogenated Organics in
               Ambient Air From Houston, TX	   273
 B-l      Metabolism Studies for Some Halogenated Organics to be
               Monitored in This Study	   279
 B-2      Metabolism Studies for Some Pesticides to be Monitored
               In This Study	   404
 D-l      Census Data for Tracts Shown  in Figure D-14	   437
                                    xx

-------
                                 ACKNOWLEDGEMENTS.

       The authors  wish to thank the following RTI  individuals for their
'participation and assistance in the program:  Dr.  J.  Bursey, Dr. K.  Tomer,
  Benjamin Harris,. Ill,  Milas  Kilkpatrick,  Doris Smith, Steve Cooper,  Nora
  Castillo,  Joseph  Davis,  Jane Barkley,  Margaret Ray,  Sandra Parks and Neal
 • Williams.   Also Drs.  Joseph  Breen and  Vincent DeCarlo and Ms.  Cindy Stroup
  of the Office of  Toxic Substances provided assistance and guidance in the
  preparation of this  report.   The assistance provided by personnel in the
  Region II office  of EPA is acknowledged for the site selection and sampling
  effort in Buffalo and Niagara, NY and  NJ.  These  individuals were Art Gervitz,
 :David Kraft,  William  Librizzi and Judhea  Menczel.       •   . •: •
    ..Finally, we  wish to express our sincere appreciation and thanks to the
 *,people in the study  areas for donating'their.premises as sampling locations.
- The cooperation  of the '"Old  Love" Canal .residents  .is especially appreciated.
                                        xxi

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                                  SECTION 1
                                 CONCLUSIONS

     During the course of acquiring information for this report, it became
apparent that a substantial volume of data existed on the measurements of
halogenated hydrocarbons in the environment, their mutagenic and carcino-
genic activity and the biological chemistry of these materials.  This
information has allowed the selection of those substances which are probably
most prominent and biologically important for a subsequent epidemiological
study.  An inadequate amount of information was available for the production
and emissions of halogenated hydrocarbons from the industry in the five
geographical areas.  Without this information, a backward extrapolation
between levels in the environment and the incidence of cancer will be very
difficult.  Furthermore, data were not available on levels in human fluids
nor the variance of the halogenated hydrocarbons in biological fluids and
tissue.  This information is important for statistical analyses and for
subsequent correlations.

-------
                                  SECTION 2
                               RECOMMENDATIONS

     Future programs which undertake a comparative analysis between pollu-
tants in the environment and in man should be extended to other chemicals
which may be potentially responsible for the increase incidence of cancer in
the Continental U.S.  It is recommended however that a pilot program be
instituted which provides the following information:  (1) environmental
levels of chemicals in air, water,  soil, sediment and the food chain; (2)
levels of the pollutants in the human biological fluids and tissue; (3)
biological testing of chemicals for carcinogenic and mutagenic activity
which is needed for the selection of the more important compou ds for
epidemiological studies; and (4) production and emission levels for chemicals
during the past 10-15 years.
     These data are required and are considered as the key ingredients in
designing a program which makes an assessment of the organic pollutants in
man and environmental media.

-------
                                   SECTION 3
                              PROGRAM OBJECTIVES

     The general broad term thrust of this program is to conduct environmental
sampling and related epidemiological studies concerning halogenated organic
compounds in five metropolitan locations within the Continental U.S.  A
comparative analysis is to be made of environmental levels (air, water,
soil, sediment and aquatic and terrestrial species) with levels of chemicals
found in the endogenous population and cancer mortality rates (in the metropo-
litan areas).  The selected halogenated hydrocarbon chemicals are to be
measured in human blood, urine and/or fat tissues.
     Under the first phase of this program, identification and quantification
of the halogenated hydrocarbons occurring in air, water, etc. are to be
performed for the sampling areas selected.  The ultimate objective is to
acquire information which will allow a statistical correlation of the levels
of halogenated organic compounds in the environmental, samples with those in
human tissue and with the incidence of mortality.
     This comprehensive report presents the information which is required
for establishing which chemicals are most important for study and establishes
those substances which most likely will contribute to a health effect.  The
report lays the foundation and rational basis for developing a model/hypothe-
sis concerning halogenated hydrocarbons and the incidence of cancer in man;
furthermore, the hypothesis is to be tested.

-------
                                   SECTION 4
                                 INTRODUCTION

GENERAL PROGRAM CONCEPT
     The general program concept which has been developed attempts to furnish
a comprehensive and systematic approach which will make a comparative analysis
of selected organic compounds in man and the environmental media.  For the
purpose of presenting an overview of the concept, Figure 4-1 depicts a flow
diagram demonstrating the 'interlocking relationship between the environment,
man and a potential association with the incidence of cancer.  This schematic
presents a number of prerequisite components of the current program which
need examination to demonstrate a potential associational relationship
between halogenated hydrocarbons and the incidence of cancer in man.  The
general program concept has been simplistically divided into three basic
levels.  The first demonstrates the dosage of man with halogenated hydrocar- •••-•
bons via environmental media such as air, water and food.  The second demon-
strates the degree of body-burden in man via examination of urine, blood,
breath and tissue for these compounds.   The last phase of the program attempts
to demonstrate an associational relationship (i-e_. , response) between body-
burden and the incidence of cancer.
CONCEPTUAL MODEL
     There are essentially three basic elements which must be present in
developing this hypothesis:  (1) a source of emissions or effluents;  (2) a
pathway by which a population might be exposed; and (3) a plausible etiologi-
cal relationship between emissions or effluent and the incidence of disease.
These essential ingredients have been incorporated into the i lodel depicted
in Figure 4-1.
     Beginning with the first level, it is advantageous to have detailed
data on specific halogenated hydrocarbons which are emitted  from industrial
plants  and processes.   In order to insure that a complete and valid picture

-------
                              INDUSTRIAL  DISCHARGE
                             SOURCES OF HALOGENATZD
                                 HYDROCARBONS
                            ANALYSIS OF ENVIRONMENTAL
                           MATRICES REPRESENTING PORTALS
                                 OF ENTRY  TO MAN
          eaographic,
         Hydrologic,
         Meteorologic,
         Topographic
            Data
                                           ANALYSIS
                                             OF
                                         ENVIRONMENTAL
                                            SINKS
         LEVEL 1:  DOSE
         LEVEL 2:  BODY BURDEN-fUrineWBlood!- rfissueJ - ffireac
                   iochemical
                  Physiologic
                   arameters
                                    Historical
                                     Etiology
         LEVEL 3:   RESPONSE
            BACK
          OR FORWARD
         EXTRAPOLATIO
             OF
          AIR/WATER
           QUALITY
                  FORMULATION OF
                    HYPOTHESES
                                                              MORTALITY AND
                                                                 MORBIDITY
                                                                 ANALYSIS
                  EVALUATION AND
                HYPOTHESES TESTING
                                   CONCLUSION
Figure  4-1.
Schematic flow diagram demonstrating  interlocking
relationships between  environment, man and
association with  incidence  of cancer.

-------
has been described, this information must be fortified with environmental
sampling and analysis.  To successfully and representatively analyze environ-
mental matrices which represent portals of entry to man, the hydrologic,
meteorologic and topographic characteristics in the geographical area selected
for study must be understood.  Such information is the basis for a rational
sampling regime for the collection and analysis of environmental samples.
Environmental sinks need also to be analyzed and the acquisition of data on
the types and concentrations of halogenated hydrocarbons which are found in
air, water and food helps to establish man's potential dosage.  Depicted in
Figure 4-2 is a more detailed pertinent relationship between discharge
sources, environmental media and man.
     To establish a dose (Level 1), body-burden (Level 2) and relationship,
it is necessary to acquire appropriate demographic data and to design a
human sampling regime which adequately represents the sampled population.
For the purpose of developing statistical cell models, detailed demographic
data must be obtained concerning each blood and urine sample.  .T^ ensure
that the proper halogenated hydrocarbons have been selected for study in the
blood and urine samples, the biomedical and physiological parameters and
information on their historical etiology must be known.  Information on the
mutagenic and carcinogenic effects of the individual halogenated hydrocarbons
should be known in order to assist the selection of a representative number
of substances for monitoring and statistical correlation.
     Subsequent to the generation of information and completion of the first
two levels of the overall program, the final phase will involve the formu-
lation of various hypotheses or models which can then be evaluated and
tested.   Information on mortality and morbidity as well as regression
analysis to account for latency factors can possibly be incorporated into
the hypotheses.   Whether or not an associational relationship can be ascertai-
ned between the  halogenated hydrocarbons in the environment, man's exposure
to these compounds  and the  incidence of cancer will depend upon the validity
of the model.
     A number of important  ingredients are envisioned for the successful
development and  testing of  the  conceptual model.  These are as follows:  (1)
there  exists  a  statistically significant excess of cancer mortality or

-------
                                                    DIRECT APPLICATION

                                                    (weed, pest control)
HALOGENATED ORGANIC
     DISCHARGE
                     /WVWWWX
                     AQUEOUS EFFLUENT

                     XAAAAAAAAA/
                                                           f-  FOOD
                                                       (animal, vegetable)
                                                                                    RESPIRATION
                                                                  AQUATIC LIFE
                                                                                                        *• MAN
   DRINKING
     WATER


         \
n   n   n
                                                                                    -*• /TREATMENT PLANT,
                                                       SEDIMENT
      Figure  4-2.   Pertinent  relationships  between discharge sources, environmental media and man.

-------
morbidity in the areas studied as compared to matched controlled areas;  (2)
medical evidence which documents that the pollutant is capable of causing
disease (etiology analysis) can be found; (3) actual measurements which
document excessive levels of halogenated hydrocarbons in the area of  interest
(air, water, and food) can be performed; (4) specific industrial process
data which document the industrial activity in a particular geographical
area which is acutally producing or has produced the halogenated hydrocarbons
can be located; (5) a means by which the pollutant is released from the
industry and transported to the population exists; (6) the presence of
halogenated substances in human biological fluid and tissue can be demonstra-
ted; and (7) production records which support the contention that the industry
was actually involved in the production of halogenated hydrocarbons during the
past 10-15 years can be found.

-------
                                   SECTION 5
                   INCIDENCE OF CANCER IN THE STUDY AREAS

     One of the objectives of this study is to compare the environmental
levels and body-burden of halogenated organics with cancer mortality rates
in the study areas.  To this end, the cancer mortality statistics for the
United States and the counties comprising the study areas have been compiled
(5-1), as shown in Tables 5-1 - 5-6.  For the study areas comprising more
than one county, an average was calculated for each cancer type.  The total
deaths in each county were summed to give the total deaths in an area.  The
death rate for the area was calculated by taking a weighted average of the
death rates for each county.  The relative rate was calculated in the same
manner as for the individual counties:  a simple ratio of the county death
rate vs. the national death rate.
     Several of the study areas exhibit high cancer incidence relative to
the national averages.  Bladder cancer and, to a lesser extent, lung cancer
are above average in the Baton Rouge area.  All cancers listed, except
testicular, are above average in the New Jersey study area.  The cancer
incidence in this area has been partially linked to the chemical and allied
industries located there (5-2).
     In the Buffalo-Niagara study area, all cancers except prostate are
above the national average.  In Greensboro (the control area) only prostate
cancer is above the national average.  Houston has high rate of malignant
neoplasm, especially of the liver, lung and bladder.
     The above discussion is intended only as a comparison of the data in
Tables 5-1 - 5-6.  In no way should it be construed at this point as an
association of halogenated organic production and/or pollution with cancer.
     Caution must be exercised in use of these data.  Very high or very low
relative death rates may result when only a few deaths have occurred,
without being significant (for example, 3 deaths yielding a death rate of
2.2).

-------
                                  Table 5-1.  US AVERAGE CANCER MORTALITY
State and
•3
County Code Cancer
(City) Type Race
United 1 White
States Nonwhite
2 White
Nonwhite
3 White
Nonwhite
4 White
Nonwhite
5 White
Nonwhite
6 White
Nonwhite
All White
Nonwhite


Total Deaths
Per 20 Years
76,070
10,021
571,226
53,910
252,763
35,397
12,918
504
57,780
4,072 :
98,304
7,001
2,572,035
264,108

Male
Sex

Death Relative0
Rate Rate
5.16
6.91
37.98
, 36.67
17.84
27.39
.83
.30
3.86
2.67
6.78
5\ 05
174.04
; 184.28
1.00
1.00
1.00
1.00
1.00
1.00
1.00
1.00
1.00
1.00
1.00
1.00
1.00
1.00


Total Death
Per 20 Years
94,229
7,261
108,326
10,222
-
-
34,204
2,429
43,095
4,758
2,258,282
228,561

Female
Death
Rate
5.34
4.59
6.29
6.27
•

1.99
1.42
2.39
3.05
130.10
139.80


Relative0
Rate
1.00
1.00
1.00
1.00
-

1.00
1.00
1.00
1.00
1.00
1.00
3Source:   US Cancer Mortality by County 1950-1969, DHEW (NIH) 74-615.  Code for Cancer Types:  1 = liver;
 2 = trachea, lung, bronchi,  etc.;  3 = prostate; 4 = testis; 5 = kidney; 6 = bladder and other urinary
 organs;  All = all malignant  neoplasms.

 Death rate is the average annual age-adjusted mortality rate per 100,000 calculated for the 20-year
 period.

°Relative Rate is the County  death rate divided by the national death rate .for, a, cancer., site.

-------
Table 5-2.  CANCER MORTALITY FOR BATON ROUGE STUDY AREA
State and —
County Code Cancer3 T
(City) Type Race P
22033
E. Baton Rouge, 1 White
LA Nonwhite
2 White
Nonwhite
3 White
Nonwhite
4 White
Nonwhite
5 White
Nonwhite
6 White
Nonwhite
All White
Nonwhite
22047
Iberville, LA 1 White
Nonwhite




Sex

Male
'otal Deaths Death
er 20 Years Rate

41
22
399
123
106
106
11
2
29
12
59
35
1,509
790

4
16

4.
5.
44.
27.
16.
25,
8.
0.
2.
2.
8.
8.
176.
176.

2.
14.

9
0
5
3
6
0
7
2
8
7
0
0
1
.2

7
1
Relative0
Rate

0.
0.
1.
0.
0.
0.
0.
0.
0.
1.
1.
1.
1.
0.

0.
2.

91
72
17
74
93
91
84
67
72
01
18
58
01
96

52
04




Female
Total Deaths Death
Per 20 Years Rate

39
28
71
29
	
-
	
-
33
9
24
14
1,300
727

3
3

3.
5.
6.
5.
_
-
	
-
3.
1.
2.
2.
114.
130.

2.
2.

7
1
3
3




0
5
4
6
8
6

1
1
Relative0
Rate

0.
1.
1.
0.
	
-
_
-
1.
1.
1.
0.
0.
0.

0.
0.

69
11
00
84




51
06
00
85
88
93

39
46
                       (continued)

-------
Table 5-2 (cont'd.)
State and
o
County Code Cancer
(City) Type Race
Iberville, LA 2 White
(cont'd.) Nonwhite
3 White
Nonwhite
4 White
Nonwhite
5 White
Nonwhite
6 White
Nonwhite
All White
Nonwhite
22121
W. Baton Rouge, 1 White
LA Nonwhite
2 White
Nonwhlfe
3 White
Nonwhite


Total Deaths
Per 20 Years
61
48
21
35
2
0
1
3
15
7
230
227

6
4
29
27
3
13

Male
Death
Rate
46.0
40.1
16.7
27.8
1.3
0
0.9
2.5
11.9
5.7
173.7
189.6

11.2
6.9
54.3
49.2
6.2
19.9
Sex



Female
Relative0
Rate
1.21
1.09
0.94
1.01
1.56
0
0.23
0.94
1.76
1.13
1.00
1.03

2.17
1.00
1.43
1.34
0.35
0.73
Total Deaths
Per 20 Years
8
8
_
-
_
-
1
1
3
10
146
156

2
2
3
6
_
-
Death
Rate
5.7
5.4
__
-
_
-
0.7
0.8
1.9
7.0
102.5
113.1

3.9
3.2
5.7
10.0
_
-
Relative0
Rate
0.91
0.86
_
-
-
-
0.35
0.56
0.79
2.30
0.79
0.81

0.73
0.70
0.91
1.59
_
-
     (continued)

-------
Table 5-2 (cont'd.)

C |- a •- & onH
D Ca LtJ anCl
County Code
(City)
W. Baton Rouge,
(cont'd.)






Baton Rouge Area
Average (Iberville,
W. Baton Rouge, and
E. Baton Rouge
Parishes)










a
Cancer
Type
4

5

6

All

1


2

3

4

5

Race
White
Nonwhite
White
Nonwhite
White
Nonwhite
White
Nonwhite
White
Nonwhite

White
Nonwhite
White
Nonwhite
White
Nonwhite
White
Nonwhite


Total Deaths
Per 20 Years
1
0
3
2
3
3
101
93
51
42

489
198
130
154
14
2
33
17

Male
Death
Rate
1.3
0
5.6
2.9
6.3
5.0
191.1
159.3
4.9
6.9
*
45.2
31.7
16.0
25.0
0.8
0.2
2.8
2.7
Sex



Female
Relative0 Total Deaths
Rate
1,57
0
1.45
1.05
0.93
0.99
1.10
0.86
0.95
1.11

1.19
0.86
0.90
0.91
0.93
0.67
0.71
1.01
Per 20 Years

-
1
0
3
3
67
89
44
33

82
43
_
-
	
-
35
10
Death
Rate

-
1.8
0
5.8
4.5
119.0
151.7
3.5
4.3

6.2
5.7
_
-
	
-
2.7
1.4
Relative0
Rate

-
0.90
0
2.43
1.48
0.91
1.09
0.66
0.95
i
0.99
0.91

-

-
1.35
0.97
    (continued)

-------
                                            Table 5-2 (cont'd.)
                                                                  Sex
                                                     Male
Female
oudLe auu
County Code
(City)
Baton Rouge Area
Average (cont'd.)

Cancer
Type
6
All
Race
White
Nonwhite
White
Nonwhite
Total Deaths
Per 20 Years

1
1
77
45
,840
,110
Death
Rate
8.'5
7.3
177.0
177.2
Relative0
Rate
1.25
1.44
1.02
0.96
Total Deaths
Per 20 Years
30
27
1,513
927
Death
Rate
2.5
3.6
113.7
129.0
Relative0
Rate
1.04
1.18
0.87
0.92
aSource:  US Cancer Mortality by County 1950-1969, DREW (NIH) 74-615.  Code for Cancer Types:   1 = liver;
 2 = trachea, lung, bronchi, etc.; 3 = prostate; 4 = testis; 5 = kidney; 6 = bladder and other urinary
 organs; All = all malignant neoplasms.
bDeath Rate is the average annual-adjusted mortality rate per 100,000 calculated for the 20-year
 period.  For average of several counties, the sum of the total deaths divided by death rate for each
 county was divided by the sum of the total deaths for all counties.
°Relative Rate is the County death rate divided by the national death rate for a cancer site.

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                  Table 5-3.  CANCER MORTALITY FOR NORTHEAST NEW  JERSEY  STUDY  AREA 1950-1969
Ln
State and
County Code
(City)
34003
Bergen, NJ
(Rutherford)












34013
Essex, NJ
(Newark)




Male
Cancer3 Total Deaths Death
Type Race Per 20 Years Rate

1 White
Nonwhite
2 White
Nonwhite
3 White
Nonwhite
4 White
Nonwhite
5 White
Nonwhite
6 White
Nonwhite
All White
Nonwhite

1 White
Nonwhite

365
14
3,090
92
1,026
11
56
1
307
1
531
8
12,863
373

536
69

5.8
9.8
46.4
67.3
18.6
29.6
o'.a
0.5
4.6
0.5
8.9
6.7
202.1
281.4

6.7
6.4
Sex

Relative0
Rate

1.12
1.42
1.22
1.84
1.04
1.08
0.96
1.67
1.19
0.19
1.31
1.33
1.16
1.53

1.30
0.93



Female
Total Deaths Death
Per 20 Years Rate

438
11
570
20
_
-
_
-
197
0
246
3
11,894
344

551
48

5.5
6.8
7.0
10.7
_
-
	
-
2.5
0
3.1
2.0
148.1
192.2

5.4
3.9


c
Relative
Rate

1.03
1.48
1.11
1.71
_
-
	
-
1.26
0
1.30
0.65
1.14
1.37

1.01
0.86
                                                   (continued)

-------
Table 5-3 (cont'd.)
State and
County Code
(City)
Essex, NJ
(cont'd,)










34023
Middlesex, NJ
(Edison, Fords)




a
Cancer
Type Race
2 White
Nonwhite
3 White
Nonwhite
4 White
Nonwhite
5 White
Nonwhite
6 White
Nonwhite
All White
Nonwhite

1 White
Nonwhite
2 White
Nonwhite
3 White
Nonwhite


Total Deaths
Per 20 Years
3,697
547
1,381
229
69
7
366 :
33
829
57
16,975
2,385

199
4
1,665
76
455
27

Male
Deathb
Rate
44.7
48.1
19.0
27.5
0.9
0.6
4.5
2,9
10.9
5.6
215.1
219.2

6.8
3.3
54.5
70.7
17.9
33.9
Sex



Female
Relative0
Rate
1.18
1.31
1.07
1.00
1.08
2.00
1.17
1.09
1.61 '
1.11 '
1.24
1.19

1.32
0.48
1.43
1.93
1.00
1.24
Total Deaths
Per 20 Years
712
107
-
—
_
-
204
30
272
50
15,258
2,155

224
8
230
11
_
-
Death
Rate
7.2
7.6
-
—
_
-
2.1
1.9
2.6
4.3
154.5
1-54.6

6.6
8.7
6.6
10.7
—
-
Relative0
Rate
1.14
1.21
-
—
_
-
1.06
1.34
1.09
1.41
1.19
1.11

1.24
1.90
1.05
1.71
_
-
    (continued)

-------
Table 5-3 (cont'd.)
State and
County Code
(City)
Middlesex, NJ
(cont'd.)






34031
Passaic, NJ
(Clifton,
Rutherford)








o
Cancer
Type Race
4 White
Nonwhite
5 White
Nonwhite
6 White
Nonwhite
All White
Nonwhite

1 White
Nonwhite

2 White
Nonwhite
3 White
Nonwhite
4 White
Nonwhite
5 White
Nonwhite


Total Deaths
Per 20 Years
24
1
149
4
230
10
6,556
282

227
9

1,835
103
591
36
35
2
178
7

Male
Death
Rate
0.6
1.0
4.7
4.0
8.4
11.5
220.8
279.0

5.9
7.0

46.3
79.2
16.6
36.4
0.9
1.1
4.6
4.5
Sex



Female
Relative0
Rate
0.72
3.33
1.22
0.15
1.24
2.28
1.27
1.51

1.41
1.01

1.22
2.16
0.93
1.33
1.08
3.67
1.19
1.69
Total Deaths
Per 20 Years
	
-
83
1
92
1
5,251
223

253
8

327
15
_
-
_
-
125
6.
Death
Rate
_
—
2.4
0.9
2.8
1.2
149.2
208.2

5.6
6.2

7.2
7.8
_
-
__
-
2.8
4.3
Q
Relative
Rate
_
—
1.21
0.63
1.17
0.39
1.15
1.49

1.05
1.35

1.14
1.24
_
-
_
-
1.41
3.03
    (continued)

-------
                                                Table 5-3 (cont'd.)
00
State and
County Code
(City)
34039
Union, NJ
(Elizabeth)












NE New Jersey
Average (Bergen,
Essex, Middlesex,
Passaic, Somerset
and Union Coun-
ties)
o
Cancer
Type Race

1 White
Nonwhite
2 White
Nonwhite
3 White
Nonwhite
4 White
Nonwhite
5 White
Nonwhite
6 White
Nonwhite
All White
Nonwhite
1 White
Nonwhite

2 White
Nonwhite



Total Deaths
Per 20 Years

235
16
1,811
123
682
• 76
38
3
218
15
369
10
8,311
620
1,616
112

12,634
960


Male
Death
Rate

5.8
6.1
42.0
48.8
19.3
39.0
0.8
0.7
5.2
5.3
9.9
4.7
203.4
252.2
6.1
6.5

46.0
53.5

Sex



Female
Relative0
Rate

1.12
0.88
1.11
1.33
1.08
1.42
0.96
2.33
1.35
1.97
1.46
0.93
1.17
1.37 •
1.19
0.94

1.21
1.46

Total Deaths
Per 20 Years

295
23
354
29
—
-
_
-
114
9
141
15
7,757
534
1,821
106

2,306
184

Death
Rate

5.8
7.0
6.9
10.1
—
—
_
—
2.3
2.7
2.8
4.8
151.6
166.3
5.6
5.4

7.1
8.4

Q
Relative
Rate

1.09
1.53
1.10
1.61
-
—
_
-
1.16
1.90
1.17
1.57
1.17
1.19
1.05
1.17

1.12
1.33

                                                     CcOTXi

-------
Table 5-3 (cont'd.)
State and
County Code
(City)
Passaic, NJ
(cont'd. )

34035
Somerset, NJ
(Bound Brook)











o
Cancer
Type Race
6 White
Nonwhite
All White
Nonwhite

1 White
Nonwhite
2 White
Nonwhite
3 White
Nonwhite
4 White
Nonwhite
5 White
Nonwhi te
6 White
Nonwhite
All White
Nonwhite


Total Deaths
Per 20 Years
331
9
7,981
355

54
0
536
19
160
8
11
0
53
1
84
2
2,151
74

Male
Death
Rate
9.0
9.7
209.5
271.5

4.5
0
44.2
63.7
15.7
30.0
0.8
0
4.3
1.6
7.9
5.6
182.8
226.9
Sex



Female
Relative0
Rate
1.33
1.92
1.20
1.47

0.87
0
1.16
1.74
0.88
1.10
0.96
0
1.21
0.60
1.17
1.11
1.05
1.23
Total Deaths
Per 20 Years
121
9
6,631
302

60
5
113
2
_
-
_
-
31
0
41
0
1,820
66
Death
Rate
2.7
6.2
141.8
182.7

4.7
18.6
8.6
8.8
_
-
_
-
2.4
0
3.0
0
135.7
228.5
Relative0
Rate
1.13
2.03
1.14
1.31

0.88
4.05
1.37
1.40
_
-
_
-
1.21
0
1.26
0
1.04
1.63
     (continued)

-------
                                           Table 5-3 (cont'd.)

State and
County Code
(City)
NE New Jersey
Average (cont'd.)










Cancer"
Type
3

4

5

6

All




Race
White
Nonwhite
White
Nonwhite
White
Nonwhite
White
Nonwhite
White
Nonwhite



Total Deaths
Per 20 Years
4,295
387
233
14
1,271
62
2,374
96
54,837
4,089

Male

Deathb
Rate
18.3
30.5
0.8
0.7
4.7
3.2
9.0
6.1
208. 5
236.2
Sex



Female

Relative0
Rate
1.03
1.11
0'. 98
2.25
1.21
1.20
1.33
1.21
1.20
1.28

Total Deaths
Per 20 Years

-
_
-
754
46
913
78
48,611
3,624

Death
Rate

-
_
-
2.4
2.1
2.8
4.2
150.2
165.0

Relative
Rate

-
_
-
1.19
1.50
1.17
. 1.38
1.15
1.18
 Source:   US  Cancer Mortality by County 1950-1969,  DHEW (NItt)  74-615.   Code  for  Cancer  Types:   1  = liver;
 2 = trachea,  lung, bronchi,  etc.;  3 = prostate;  4  = testis;  5 = kidney;  6 = bladder  and  other urinary
 organs;  All  = all malignant  neoplasms.

 Death Rate is the average annual age-adjusted mortality rate per 100,000 calculated for the 20-year
 period.   For average of  several counties,  the sum  of the total deaths  divided by death rate for  each
 county was divided by the sum of the total deaths  for all counties*
t
"Relative Rate is  the County  death  rate by  the national death rate for  a  cancer  site.

-------
Table 5-4.  CANCER MORTALITY FOR THE BUFFALO-NIAGARA, NY STUDY AREA
State and
County Code
(City)
36029
Erie, NY
(Buffalo)












36063
Niagara, NY
(Niagara
Falls)


Q
Cancer
Type

1

2

3

4

5

6

All


1


2

Race

White
Nonwhite
White
Nonwhite
White
Nonwhite
White
Nonwhite
White
Nonwhite
White
Nonwhite
White
Nonwhite

White
Nonwhite

White
Nonwhite


Total Deaths
Per 20 Years

530
43
4,531
300
1,491
3
99
1
438
21
874
19
18,959
1,087

105
4

922
24

Male
Death
Rate

5.8
9.6
47.8
61.5
17.8
41.6
1.0
.1
4.6
4.2
9.9
3.9
207.0
237.0

5.3
8.5

45.5
51.3
Sex



Female
Relative
Rate

1.12
1.39
1.26
1.68
1.00
1.52
1.20
0.33
1.19
1.14
1.46
0.77
1.19
1.29

1.03
1.23

1.20
1.40
Total Deaths
Per 20 Years

648
17
631
42
_
-
„
-
239
14
333
23
15,598
797

130
0

145
1
Death
Rate

5.9
3.4
5.8
8.1
_
—
_.
-
2.2
2.6
3.0
5.2
142.3
161.2

5.9
0

6.6
3.2
Relative0
Rate

1.10
0.74
0.92
1.29
—
—
__
-
1.11
1.83
1.26
1.70
1.09
1.15

1.10
0

1.05
0.5
                            (continued)

-------
                                                Table 5-4 (cont'd.)
N>
State and
County Code
(City)
Niagara, NY
(cont ' d. )






Buffalo/Niagara
Average (Erie
and Niagara
Counties)





Male
Cancer3 Total Deaths Death
Type Race Per 20 Years Rate
3 White
Nonwhite
4 White
Nonwhite
5 White
Nonwhite
6 White
Nonwhite
All White
Nonwhite
1 White
Nonwhite
2 White
Nonwhite
3 White
Nonwhite
282
9
24
0
79
1
155
0
3,635
76
635
47
5,453
324
1,773
12
15.6
29.1
1.1
0
4.0
4.1
8.2
0
,; 184.2
182.1
5.7
9.5
47.4
60.6
17.4
31.5
Sex

Relative0
Rate
0.87
1.06
1.33
0
1.04
1.54
1.21
0
1.06
0.99
1.11
1.37
1.25
1.65
0.98
1.15



Female


b c
Total Deaths Death Relative
Per 20 Years Rate Rate
-
-
43
2
64
1
3,008
57
778
17
776
43
-
-
-
2.0
1.8
2.9
2.4
135.8
143.5
5.9
3.4
5.9
7.8
-
-
-
1.00
1.27
1.21
0.8
1.04
1.03
1.10
0.74
0.94
1.24
-
                                                    (continued)

-------
                                              Table 5-4  (cont'd.)
CO

State and

County Code
(City)
Buffalo/Niagara
Average
(cont'd.)












Cancer
Type
4


5

6

All

Race
White
Nonwhite

White
Nonwhite
White
Nonwhite
White
Nonwhite




Total Deaths
Per 20 Years
123
1

517
22
1,029
19
22,594
1,163

Male

V,
Death
Rate
1.0
0.1

4.5
4.2
9.6
3.9
203.0
232.4
Sex



Female




Relative Total Deaths
Rate
1.23
0.3

1.17
1.57
1.42
0.77
1.17
1.26
Per 20 Years
	
-

282
16
397
24
18,606
854

K
Death
Rate
	
-

2.2
2.5
3.0
5.0
141.2
159.9

£
Relative
Rate
_
-

1.09
1.73
1.25
1.63
1.08
1.14
   Source:  US Cancer Mortality by County 1950-1969, DHEW  (NIH)  74-615.  Code for Cancer Types:  1 - liver;
   2 = trachea, lung, bronchi, etc.;  3 = prostate; 4 = testis; 5 = kidney; 6 = bladder and other urinary
   organs; All = all malignant neoplasms.

   Death Rate is the average annual age-adjusted mortality rate per 100,000 calculated for the 20-year
   period.  For average of several counties,  the sura of the total deaths divided by death rate for each
   county was divided by  the sum of the  total deaths for all counties.

   ^Relative Rate is the County death  rate by  the national death  rate for a cancer site.

-------
                           Table  5-5.   CANCER MORTALITY FOR GREENSBORO, NC STUDY AREA
N>
State and
County Code
(City)
37081
Guilford, NC
(Greensboro)






rj
Cancer
Type Race
1 White
Nonwhite
2 White
Nonwhite
3 White
Nonwhite
4 White
Nonwhite
5 White
Nonwhite
6 White
Nonwhite
All White
Nonwhite


Total Deaths
Per 20 Years
11
5
472
118
216
92
10
0
50
9
48
25
2,018
618

Male
Death
Rate
2.9
2.8
33.6
36.1
19.3
36.9
.5
0
3.4
2.9
3.8
9.0
148.4
202.1
Sex



Female
Relative0
Rate
0.56
0.41
0.88
0.98
1.08
1.35
0.60
0
0.88
1.09
0.56
1.78
0.85
1.10
Total Deaths
Per 20 Years
17
3
93
21
-
-
35
3
39
11
2,004
545
Death
Rate
3.5
1.3
5.2
5.8
-
-
2.0
.6
2.4
2.8
113.6
140,3
Relative0
Rate
0.66
0.3
.0.83
0.93
-
-
1.00
0.4
1.00
0.92
0.87
1.00
   3Source:   US  Cancer  Mortality by County 1950-1969,  DHEW (NIH)  74-615.   Code for Cancer Types:  1 = liver;
    2 =  trachea,  lung,  bronchi,  etc.;  ? =  prostate;  4  = testis;  5 = kidney;  6 = bladder and other urinary
    organs; All  = all malignant neoplasms.

   ''Death Rate is the average  annual age-adjusted mortality rate  per 100,000 calculated for the 20-year
    period.   For average of  several counties,  the sum  of the total deaths divided by death rate for each
    county  was divided  by the  sum of the total deaths  for all counties.

-------
                           Table  5-6.   CANCER MORTALITY  FOR THE HOUSTON,  TX STUDY AREA
tn
State and
County Code
(City)
48201
Harris, TX
(Houston)












a
Cancer
Type Race

1 White
Nonwhite
2 White
Nonwhite
3 White
Nonwhite
4 White
Nonwhite
5 White
Nonwhite
6 White
Nonwhite
All White
Nonwhite


Total Deaths
Per 20 Years

391
160
3,684
726
939
388
78
3
255
64
408
109
12,286
3,183

Male
Death
Rate

6.1
10.0
53.5
44.4
18.9
30.1
0.8
0.2
3.7
3.6
7.4
7.4
188.5
203.8
Sex



Female
c
Relative
Rate

1.18
1.45
1.41
1.21
1.06
1.10
0.96
0.7
0.96
1.35
1.09
1.47
1.08
1.11
Total Deaths
Per 20 Years

321
94
713
123
_
-
_
-
165
28
169
53
10,014
2,553
Death
Rate

4.3
5.4
8.8
7.0
_
-
_
-
2.1
1.4
2.3
3.1
124.2
139.5
c
Relative
Rate

0.80
1.18
1.40
1.12
_
-
_
-•
1.06
0.99
0.90
1.02
0.95
1.00
    Source:   US  Cancer  Mortality  by  County  1950-1969,  DHEW  (NTH)  74-615.   Code for Cancer Types:   1 = liver;
    2 = trachea,  lung,  bronchi, etc.;  3  = prostate;  4  =  testis;  5 =  kidney;  6 = bladder  and other urinary
    organs;  All  = all malignant neoplasms.

    Death Rate is the average  annual age-adjusted morality  rate  per  100,000  calculated for the  20-year
    period.   For average  of  several  counties,  the sum  of the  total deaths  divided  by death rate for each
    county was divided  by the  sum of the total deaths  for all counties.
   "Relative Rate is  the  County death  rate  by  the national  death rate  for  a  cancer site.

-------
Similarly, for counties and cancers in which several thousand deaths were
reported, a small deviation from 100 may be significant.   The significance
of the data (and therefore the applicability to this project) will be calcu-
lated during the data analysis phase.
                                    26

-------
                                  SECTION 6
                 POTENTIAL SOURCES OF HALOGENATED HYDROCARBONS

     In order to plan the sampling strategy, it is important to know as
much as possible about the potential sources of halogenated compounds.  To
this end,  all available resources have been used to obtain data on halogena-
ted organic compound manufacturers, users, and disposal facilities.  As
discussed  below, the information is far from comprehensive.  Realizing the
limitations of the data, RTI feels it can make an intelligent selection of
sampling sites with the data now in hand concerning the potential sources
of halogenated hydrocarbons.
MANUFACTURING LOCATIONS
     The known halogenated hydrocarbon manufacturing locations are listed
in Tables  6-1 - 6-4.  No halogenated hydrocarbon manufacturing locations
have been  found in Greensboro, NC.  In addition to the sources of data
listed in  the footnotes to the tables, data obtained in previous contracts,
contacts with EPA, state, and local officials, and chamber of commerce
literature have been used to augment and verify the data.
NEW JERSEY AIR EMISSIONS DATA
     Airborne plant emission data were obtained from Dr. Jehuda Menczel,
Air Facilities Branch, EPA, Region II, New York, for several plants in New
Jersey which represent potential study sites.  The raw data were evaluated
and summarized by RTI:
     Pentasote (Passaic) manufactures polyvinyl chloride and was reported
to emit 500 tons/year VCM (11/78 = 50 T/yr).
     Givaudan (Clifton) had only ethylene dichloride (^1.2 T/yr) as a
significant emission, so it probably does not represent a good study site.
     Tenneco (Fords) reportedly emits chlorotoluene, dibromopropanol, and
dibromopropylphosphate.  Since this is a batch operation, deciphering the
emission rates was not possible.
                                     27

-------
           Table 6-1.   HALOGENATED HYDROCARBON  MANUFACTURING LOCATIONS  IDENTIFIED FOR
                       POPULATION DENSITY MAPPING —  NORTHERN NEW JERSEY  AREA    •
Company
Tenneco Chem. Co.
Stauffer
DuPont
GAF
IMC Chem. Co.
(Defunct)0
Prentlss Drug and
Chem. Co.
Troy Chem. Co.
Standard Chlorine
Chem, Co.
Municipality
Fordg
Edison
Linden
(Tremley Pt.)
Linden
Newark
Newark
Newark
Kearney
Compounds Manufactured ,
toxaphene
f enac
2,3,6-trlchlorobenzolc
acid and salts
o-chloro toluene
benzyl chloride
o-chloro toluene
benzyl chloride
methoxychlor
chloroneb
2,4,5-T
propanil
llndane
methoxychlor
chlordane
chloromethoxypropylmercuric acid
dichlorobenzene
trlchlorobenzene
Population
Location Obtained
40.3166°N, 74.3223°W
(40"31'00°, 74°19 20")
40.4905°N, 71.3873'W
(40° 29 '26", 74°23'1V)
40.5959'N, 74.2042°H
40.6137°N, 74.2139°U X

40.7816'N, 74.1446°\l X
40.7186°N, Ti.l4i,0°V X
40.7506'N, 7A.1068°W X
Population
Radius
5
5
5
5

5
5
5
UOPf Inc.
E. Rutherford        chloro-(£-chlorophenyl)phenyl-
                   methane
                  (o-chlorophenyl)acetonitrile
                  chlorodlphenylmethane
                  ct-chlorotol uene
                  cihnamoyl chloride
                  proplonyl chloride
                  trlmedlure
                  o^-chlorotoluene (user)
                  benzyl chloride (user)
                                                                       40.8302'N,  74,0887*W
                                                    (continued)

-------
                                                                       Table  6-1  (cont'd.)
               Company
                         Municipality*
                                                          Compounds Manufactured
                                                                                                    Location
                                                                                                                              Population
                                                                                                                                 Hap
                                                                                                                               Obtained
                                                                                                            Population
                                                                                                              lUdlus
UD
           American Cyanamid
           Merck
           White Chem. Co.
W.  A.  CJeary Corp.

Clvaudan

Coaan  Clteut.  Co.

Blue Spruce  Co.



Hercules,  Inc.

1CI United States,
   Inc.

Chevron

KlnBuc Dump
(rloued)
                          Bound Brook





                          Railway


                          Bsyonne
Somerset

Cllfcon

Clifton

bound Brook



Parlln

Bayonne


S. Plalnfleld

Edison
chloroform (user)
ethylene dlchlorlde  (user)
chlorobenzene (user)
trichlorobenzene (user)

chloroform (user)
methylene chloride  (usar)

62 HliC's listed Including;
acid chlorides
alkyl chlorides
alkyl bromides
  and fire retardanta

MCPP (mecroprop)

hexachlorophene

"halogenated organlcs"

propanil
3,4-dichloroanillne
l,2-dichloro-4-nitrobenzene

chlorinated parafflna

chlorinated paraffins


aa led
                                                             40.5576"M,  7
                                                             (40*33'27"N,  74°33'14MW)
                                                                                                  40.6U9°N, 74.2719°U
                                                                                                  (40°36'43"N, 74°16'19"W)

                                                                                                  10.6520^, 74.1125"W
                                                                                                  40.8312"N, 7

                                                                                                  40.8322°N, 74.1053°W
                                                                             (continued)

-------
                                                  Table  6-1 (cont'd.)
Company
Halocarbon Pro-
ducts Corp.
Municipality"
Hackensack
Compounds Mamif actured
bromotrlf luoroethylene
chlorodlf lueroacetlc actd
Pop itlat Ion
Map
Location Obtained

Population
Radlua

                                      chlorotrlfluoroethylene
                                      tetrachlorohexafluorobutane
                                      trichloroheptafluorobutane
                                      trifluoroacetic acid
                                      trlfluoroacetlc anhydride
                                      trlf liiorocthanol
                                      trlfluoropropone
                                      ttIfluoropropene
     Sources of data include:   1.  1977  Directory  of Chemical  Producers  - USA, Chemical Information
                                       Services, Stanford Research Institute, Menlo Park,  CA  94025.
                                   2.  Personal communication,  D.  K. Oestreich, EPA,  IERL, RTP, NC  27711.

     locations obtained from plant sites on USGS  7 1/2 minute  quadrange  maps.  Plants located through
      prior RTI experience or contacts  with local officials.

°    °Source:  A.  Thornton,  NJ Board of Air Pollution.

-------
  Table 6-2.   HALOGENATED HYDROCARBON MANUFACTURING LOCATIONS  IDENTIFIED FOR POPULATION  DENSITY
                                   MAPPING — BATON ROUGE AREA
Company Municipality
Clba-Celgy St. Gabriel
Ethyl Baton Rouge
Allied, North baton Rouge
Allied, South Baton Rouge
Herculea Plaquemlne
Dou Plaquemlne
Sources of data include:
Compounds Manufactured
liexachlorobutadiene
ch lo rod Ime Corn
atrazlne
slmazlne
trlchloroethylene (50)
1,1,1-trlchloroethane (40)
1,2-dichloroethane (330)
tetrachloroethylene (50)
vinyl chloride (330)
1,2-dichloroethane (300)
vinyl chloride (300)
dlallfor
1,2-dichloroethane (450)
etrachloroethylene (150)
Inylldfne chloride
inyl chloride (450)
, 2 , 3-trlchloropropene
, 2-dichloropropane
methylene chloride
Population
Hap
Location Obtained
30.440°N, 91.0968°U
30.4968°N, 91. 1814 °W
(30°29'48", 91°19'53")
30.4954'M, 91.1881°U
39.4742°N, 91.1B70°W
(30°28'27", 91*11'13")
30.2679°N, 90.5315'U
30. 3179°N. 91.2324°W
1. 1977 Directory of Chemical Producers - USA,
Services, Stanford Research Institute, Menlo
2. Personal communication, D. K. Oestreich, EPA
X
X
X
X
X
X
Population
Radlua
10
5
5
5
10
10
Chemical Information
Park, CA 94025.
, IERL, RTP, NC 27711.
 Locations  obtained  from plant  sites  on USGS  7  1/2  minute  quadrange maps.   Plants  located  through
 prior  RTI  experience or contaccs  with  local  officials.

'Midwest  Research  Institute,  "Sampling  and Analysis of  Selected  Toxic  Substances,  Task  B.
 Hexachlorobutadiene" EPA 560/6-76-015,  June  1976.

-------
            Table 6-3.    HALOGENATED  HYDROCARBON  MANUFACTURING  LOCATIONS  IDENTIFIED  FOR POPULATION  DENSITY
                                                        MAPPING —  BUFFALO/NIAGARA AREA
                                                                                                                      Population

               Company3             Municipality"        Compounds Manufactured3                  Location*5                 Obtained           Radius
           Occidental Petroleum      Niagara Falls        c«-cliIorotoluene                       43.0790°N  79 0106°W
             Corp.,  Hooker Chem.                         £-chlorotoluene
             subsId.                                    I»2,4-trlchlorobenzene
                                                       1,2,3-trlchlorobenzene
                                                       pentachlorobenzene
                                                       lindane
                                                       one
                                                       dlenochlor
                                                       mi rex
                                                       endosulfan
                                                       glytac (EGT)
                                                       c>-chlorobenzald«hyde
                                                       £-chlorobenzaldehyde
                                                       o-chlarobenzolc acid
                                                       ra-chlorobenzoyl chloride
                                                       c>-, m-, j>~chloro-ata,a-trlfluoro-
                                                         toluene
CO                                                     2,4-dlchlorobenzotrifluoride
^                                                     2,4-dlchlorobenzotrichloride
                                                       2,4-dichlorotoluene
                                                       hexachlorocyclopentadlene
                                                       isophthaloyl chloride
                                                       tcrephtbnloyl chloride
                                                       ava^a-trlchlorotoluene
                                                       a,a,a-trlfluorotoluene
                                                       chlorotrlfluoroetliylene, poly-
                                                         merized
                                                       1,4,5,6,7,7-hexachloro-5-nor-
                                                         borncne-2,3-dlcarboxyllc acid

           ICC Industrie,          Niagara Falls        chlorobenzene                         43.0800°N,  79.0232°W
             Inc. Solvent Chem,                          o-f m-, £-dlchlorobenzene
             Corp., subs Id,                              trichlorobenzene

-------
                                              Table 6-3 (cont'd.)
OJ
Company Municipality Compounds Manufactured
Goodyear Tire and Niagara Falls polyvinyl chloride
Rubber Co., resins
Chemicals Dlv.
Old Love Canal0 Niagara Falls C
S Area Dump Niagara Falls c
102nd St. Uumpd Niagara Falls c
Hyde Park Dump Niagara Falls C
Buffalo Color Corp. Buffalo dyes
(formerly Allied
Chemical Co.
DuPont, Plastics Buffalo fluorocarbon resins
Products and
Resins Department
Populat ion
Map
Location Obtained
43.0859°N.
(43°05'09",
43.0776°N,
(43°04'39",
43. 0762 °H.
(43.04*34",
43.0732*N.
(43°04'24",
43.1323°N.
(43°07'56"t
42.8699°N,
(42°52'12"N
42.9642°N,
79.0023°W
79°00'08")
78.9499°W
78"57'00")
79. 0064 °W
79°00'23")
78.9481'W
78°56'53")
79.0393'W
79°02'21")
78.8437°W
, 78°50'37"U)
78.9177°W
Population
Radius
5
5



3
5
     aSources of data include:   1.   1977 Directory of Chemical Producers - USA,  Chemical Information
                                    Services,  Stanford Research Institute,  Menlo Park,  CA  94025.
                                2.   Personal communication,  D. K.  Oestreich,  EPA,  IERL,  RTF,  NC  27711.
      Locations obtained from plant sites on USGS 7 1/2 minute quadrangle maps.   Plants  located through
      prior RTI experience or contacts with local officials.
      Industrial Waste Disposal Area.
      Source:  Assessment of the Extent of Environmental Problems  Posed by Hooker Chemical Dumps in
      Niagara Falls, New York and Estimated Cleanup Costs by  F.  C.  Haut, Assoc., New York, December
      11,  1978.

-------
Table 6-4.  IIALOGENATED HYDROCARBON MANUFACTURING LOCATIONS IDENTIFIED FOR POPULATION DENSITY
                                   MAPPING — HOUSTON AREA
Company
Ethyl Corp.


Shell Chem. Co.







Diamond Shamrock


Pearsall Chem. Corp.
Chemetron

Mobay Chem. Corp.
Upjohn
Rollins Environ-
mental
DuPont







Municipality8
Pasadena


Deer Park







Deer Park


taPorte
LaPorte

Cedar Bayou
LaPorte
Deer Park

LaPorte







Compounds Manufactured '
vinyl chloride
1,2-dlchloroethane
chloroethane
vinyl chloride
eplchlorohydrin
ethylene dlchlorlde
3-chloropropene
cbloroethane
1, 3-dlchloropropene
lt 2-dlchloropropane
1,2, 3-trlchloropropane
1 , 2-d Ichloroe thane
trlchloroethylene
tetrachloroethylene
chlorinated paraffins (20)
phosgene
chloroformate esters
phosgene
phosgene
d

bromacll
dluron
llnuron
maneb
monuron
slduron
terbacll
neburon
Population
Map Population
Location0 Obtained Radius
29.7«05°N, 95.1694°W X 5


29.7149'N, 95.1235°W X 5
(29°42'5V, 95°07'25")






29.7296"N, 95.1109°W X 5






29.7196°N, 95.0870"W X 5
29.7305°N, 95.0952°W X 5

29. 7001 °N, 95.0366°W X 5







                                        (continued)

-------
                                             Table 6-4 (cont'd.)
CO
u\

Company
Union Carbide
Pet rotex
Gulf Cliemlcal

Municipality"
Texas City
Houston
Texau City

Compounds Manufactured '
1,2-dichloroeflinne (150)
1 , 1 ,2-trlchloroethane
1.4-dlchlorobut-2-ene
3,4-dichlorobut-l-ene


Location
29.3722-N,
(29.22'20".
29.7010°N,
(29°42'04",
29.3569-N,

c
94.
95.
95
94.


9444"U
°51'40")
2564 °W
°15'23")
9417"W
Population
Map
Obtained
X
X
X

Population
Radius
3
3
3
Sources of data include:  1.  1977 Directory of Chemical Producers - USA,  Chemical Information
                               Services, Stanford Research Institute, Menlo Park,  CA  94025.
                           2.  Personal communication, D. K.  Oestreich,  EPA, IERL, RTF,  NC  27711.
 Numbers In parenthesis are annual production capacity - millions of pounds.
°Locations obtained from plant sites on USGS 7 1/2 minute quadrange maps.   Plants  located through
 prior RTI experience or contacts with local officials.
 Waste disposal facility.

-------
     Hoffman LaRoche (Nutley) uses a large volume of solvents such as methy-
lene chloride and halogenated intermediates.   The emissions profile here is
similar to that of Merck, so it was not included as a preliminary site.
     Merck (Rahway) was reported to have low level emissions of some chlorina-
ted aromatics and other halogenated intermediates.  However, two solvents,
chloroform (10.7 T/yr) and methylene chloride (742 T/yr),  were reported to be
emitted in large quantities.
     Ciba-Geigy (Summit) reportedly has only very low emissions of some
organic intermediates.  Thus, it is an unsuitable site.
     Toms River Chemical (Toms River) was reported to emit a variety of
chlorinated aromatics at low levels as well as epichlorohydrin (5635-36
Ib/yr).  These emissions are significant, but discussions  with Region II
personnel indicated that there is no human population near the plant site,
so this site does not appear to be suitable for this study.
     American Cyanamid (Bound Brook) was reported to emit  a variety of halo-
genated organics, most notably chloroform (35 T/yr), ethylene di-hloride
(24 T/yr), chlorobenzene (16 T/yr), and trichlorobenzenes  (8.4 T/yr).  These
high levels, coupled with reportedly (Region II personnel) high nearby
population, make this a prime candidate as a study site.
     Chevron (S. Plainfield) is merely a pesticide formulator.  Their emis-
sions are reportedly confined to particulate and petroleum fraction solvents.
This site does not appear to be suitable for this study.
OTHER POTENTIAL EMISSION SOURCES
     In addition to the manufacturing facilities listed in Tables 6-1 - 6-4
and the other miscellaneous sources discussed above, there are a number of
other important sources of halogenated organics.  Dry cleaners use halogenated
solvents (generally trichloroethylene or 1,1,1-trichloroethan.e) in their
processes and may be suspected of high emissions due to poor controls and
practice.  This source is especially important in that dry cleaning .establish-
ments are often located in or near residential areas.  Information about dry
cleaning activities in the sampling sites should be collected during field
activities.  Various industries use halogenated solvents for degreasing
metal parts and similar uses.  Information on these users and potential
emissions does not appear to be available.  A wide range of other industries
                                     36

-------
could  use  (and  emit)  halogenated solvents,  including pharmaceutical formula-
tors,  manufacturers of  synthetic organic chemicals,  cleaning product manufac-
turers,  flavor  and  fragrance  industries, textile processing plants, spice
extractors,  rubber  industry,  and polymers.   The emissions from these indus-
tries,  as  discussed for some  potential New  Jersey sampling sites (vida
supra),  can  be  significant.   However,  information on the users and, more
importantly,  their  emissions  is  lacking.
    The population at  the  study sites is also potentially exposed to a
variety of pesticides (herbicides,  fungicides, fumigants, insecticides,
etc.)  applied indoors and outdoors  in residences, commercial establishments,
and at work.  There is  no way to anticipate these sources.  Potential
exposure from these sources may  be  determined only from the study question-
naire  administered  during field  sampling.
     In addition  to industrial use,  transfer and disposal could potentially
emit significant  amounts of halogenated organics.  The known industrial
waste  disposal  sites  have been included in  Tables 6-1 - 6-4.
    Finally, domestic  uses of halogenated  organics  in cleaning, hobbies,
etc.,  must be recognized.  The levels of exposure will be ascertained from
the study  questionnaire during field sampling.
                                     37

-------
                                   SECTION 7
          MEASUREMENT OF HALOGENATED HYDROCARBONS IN THE ENVIRONMENT

INTRODUCTION
     Figure 4-1 presented the general scheme of this research program.  In
order to determine which halogenated hydrocarbons might contribute to a health
impact on the human population, it has been necessary to acquire information
concerning the potential sources of halogenated hydrocarbons as well as to
provide some measurements of the environment.   It is the intent of this section
to provide information which has been acquired under this as well as other
research programs on measured levels of halogenated hydrocarbons.  These data
are needed not only to ascertain which halogenated hydrocarbons ^^e most impor-
tant for study, based on their prevalence and magnitude of occurrence, but to
assist in selecting the sites within the five geographical areas for comparison.
     The information presented in this-section was obtained by consulting the
open literature, and by conducting a pilot study.  Primary emphasis was given
to ambient air and drinking water as part of the environmental samples acquired
and analyzed under this program while the levels of halogenated organic compounds
found in other environmental media were obtained through consulting previously
reported information.
HALOGENATED ORGANICS IN FOOD AND HUMAN TISSUE IN THE UNITED STATES FOOD
     Table 7-1 presents the level of halogenated organic compounds which have
been found in food in the United States.  The predominant halogenated hydrocar-
bons are DDT, DDE, DDD, and PCB's in fish and shell fish.  Average concentrations
were 2-400 ppb for DDD, DDE, and DDT.  Somewhat lower PCB concentrations have
been reported.  Many other halogenated hydrocarbons (pesticides) have also been
detected in food but only at trace levels.  Thus it appears the most  important
compounds which should be considered for monitoring under phase II might be
DDT, DDE, DDD, and PCB's in food.
                                     38

-------
                        Table  7-1.   LEVELS OF HALOGENATED ORGANIC COMPOUNDS FOUND IN FOOD
                                              IN THE UNITED STATES
LO
l-D
Chealcul Food Type
DOE seal fat
sea duck meat
bivalves
Crustacea
benthlc fish
pelagic fish
sugar beet pulp
dairy products
potatoes
leafy vegetables
root vegetables
garden fruits
oils, fats, shortening
ODD bivalves
Crustacea
benclilc fish
pelagic fish
DDT seal Cat
bivalves
Crustacea
benthlc fish
pelagic fish
sugarbeet pulp
dairy products
meat, fish, poultry
potatoes
leafy vegetables
root vegetables
garden fruits
oils, fats, shortening
sugars and adjuncts
Cone. Mean"
(ppb)
105
4
510
840
450
450
<10
2
1
1
1
T
T
360
120
140
170
19
130
40
410
380
<10
T
6
T
T
6
T
T
T
Cone, range
(ppb)


410-570
670-920
270-700
290-650
N.D.e-160
T-12
T-5
T-6
N.D.-14

T-12
280-480
40-330
50-250
110-240

110-170
N.D.-80
250-590
190-550
N.D.-50

T-15
T-15





Number of
Determinations
1
1
34
47
84
96
114
30
30
30
30
30
30
34
47
84
96
1
34
47
84
96
114
30
30
30
30
30
30
30
30
Location
Hooper Bay, AK
Hooper Day, AK
N.
N.
N
N.







N.
N
N
N
H.
.U.
.U.
.U.







.U.
.U.
.U.
.U.
Atlantic
Atlantic
Atlantic
Atlantic







Atlantic
Atlantic
Atlantic
Atlantic
Hooper Bay, AK
N
N.
N
N.









.U.
.U.
.U.
.w.









Atlantic
Atlantic
Atlantic
Atlantic









Reference
7.
7.
7.
7.
7.
7.
7.
7.
7.
7.
7.
7.
7.
7.
7.
7,
7.
7.
7.
7 ,
7
7,
7.
7
7.
7
7
7
7
7,
7.
1
1
2
2
2
2
3
.4
4
.4
.4
.4
.4
, 2
,2
.2
,2
.1
,2
,2
.2
.2
.3
.4
.4
.4
.4
.4
.4
.4
.4
                                                   (continued)

-------
Table 7-1 (cont'd.)
Chemical
PCD'S







Toxaphene
Ferthane

Pentachlorophenol



Dleldrln









Dicofol
Endosulfan



Food Type
bivalves
crnstacea
benthic ftsh
pelagic fish
dairy products
meat, fish poultry
potatoes
oils, fats, shortening
sugarbeet piilp
leafy vegetables
fruits
gelatin
dairy producte
leguminous vegetables
sugars and adjuncts
sugar beet pulp
dairy products
meat, fish, poultry
potatoes
leafv vegetables
leguminous vegetables
garden fruits
fruits
oils, fats, shortening
oysters
fruits
potatoes
leafy vegetables
garden fruits
fruits
Cone . Mean
(ppb)
16
46
61
700
T
T
T
T
<30
44
2
26
T
10
3
<10
2
4
1
T
T
3
T
T
7
2
1
19
T
T
Cone, range
(ppb)
2-51
14-70
6-600
46-9700




N.D.-340

13-20
N.D.-6.4
T-10

1-20
N.D.-10
T-5
1-10
T-7


T-12

T-4

T-44
T-15
T-4 39
T-2
T-7
Number of
Determinat Jons Location
34 N.W. Atlantic
47 N.W. Atlantic
84 N.W. Atlantic
96 N.W. Atlantic
30
30
30
30
114
30
30
4
30
30
30
114
30
30
30
30
30
30
30
30
30
30
30
30
30
30
Reference
7.2
7.2
7.2
7.2
7.4
7.4
7.4
7.4
7.3
7.4
7.4
7.5
7.4
7.4
7.4
7.3
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.4
    (continued)

-------
Table 7-1 (cont'd.)
Chenlcal
Llndane




Aldi In
Endrin

lleptachlor epoxlde


BUG




Chlordane
Methoxychlor
Peutachloroanillne
THE







Food Type
dairy products
meat, fish, poultry
potatoes
garden fruits
sugars and adjuncts
garden fruits
potatoes
oysters
dairy products
meat, fish, poultry
potatoes
dairy products
meat, fish, poultry
garden fruits
oils, fats, shortening
sugars and adjuncts
garden fruits
dairy products
oils, fats, shortening
dairy products
meat, fish, poultry
potatoes
leafy vegetables
leguminous vegetables
garden fruits
oils, fats, ahor ten Ing
sugars and adjuncts
Cone. Mean
(ppb)
T
T
1
6
T
Td
T
T
T
T
T
1
T
T
T
T
T
T
3
T
2
T
T
T
1
1
T
b
Cone, range
(ppb)
T-.6
T-3

*
; T-2



T-2
T-2

T-4
T-3
1-2
T-5
T-5

T-2
3-32
T-l
T-ll



T-9
T-21

Number of
Determinations Location
30
30
30
30
30
30
30
Louisiana
30
30
30
30
30
30
30
30
30
30
30
30
30
30
30
30
30
30
30
Reference
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
.4
.4
.4
.4
.4
.4
.4
.6
.4
.4
.4
.4
.4
.4
.4
.4
.4
.4
.4
.4
.4
.4
.4
.4
.4
.4
.4
   (continued)

-------
                                         Table 7-1  (cont'd.)
Chemical
l,2,4,5-Tetrachloro-3-nltrobenzene





Hexachlorobenzene



Phosalone
Polychlorodlbenzo-jj-dloxin
Ronnel
Strobane
Pentachloronltrobenzene
Oc tachlorodlbenzo f uran
Hep tachlorodlbenzof uran
Food Type
meat, fish, poultry
grain and cereal
potatoes
garden fruits
fruits
oils, fats, shortening
dairy products
meat, fish, poultry
root vegetables
oils, fats, shortening
fruits
gelatin
fruits
leguminous vegetables
oils, fats, shortening
gelatin
gelatin
Cone. Mean
(ppb)
1.1
5
7
5
1
T
.6
1
T
1
T
.9
T
T
T
<.4
<•< :
Cone, range Number of
(ppb) Determinations Location
30
30
32-173 30
30
30
30
30
T-41 30
30
T-6 30
^30
N.0.-30 : 7
:30
•30
T-2 30
1
1
Reference
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.4
7.5
7.4
7.4
7.4
7.5
7.5
aAs presented in primary reference.


 Minimum and maximum values reported in primary references.

*-»
 General U.S. unless otherwise indicated.


 Trace concentration.

6
 Not detected.

-------
Emphasis  probably should be given to fish and shellfish since they  represent
potential biomagnification in the food chain.
Serum/Blood
     The  levels of halogenated organic compounds in human serum, plasma  and
blood in  the United States are given in Table 7-2.  Again, as in food, the
predominant pesticides observed were p_,p_'-DDD, o,p_'-DDE, p_,p_'-DDE,  DDE,
o,p_'DDT,  p_,p_'-DDT, and DDT.  Furthermore, (3-BHC and dieldrin levels were
significant.  In general, the mean concentrations of pesticides were  less
than 50 ppb.  Also, higher concentrations of the pesticides are found in
blood than in plasma and serum.
Milk
     A number of determinations on the levels of halogenated organic  compounds
in human  milk have been made and are listed in Table 7-3.  The general
trends are similar to those observed in human serum.  The concentrations of
pesticides in milk fat were found to be considerably higher than in milk
and often mean concentrations of greater than 100 ppb were observed.
Tissue
     Table 7-4 presents the levels of halogenated organic compounds found
in human  tissue in the United States.  Again, pesticides have been  studied
and the general trend is for higher concentrations to be observed in  adipose
tissue (fat) as compared to other human tissues.  Relatively high concentra-
tions of  p-BHC, £,£'-DDE, DDE and £,£f-DDT have been measured.  The concen-
trations  in adipose tissue are, in general, an order of magnitude greater
than in any case of the other types of human tissue.
     Very high concentrations of some pesticides are observed in adipose
tissue with levels exceeding 1 ppm.  For the observations reported, the  DDE
levels were the highest reaching 7 ppm (mean concentration) with a  range
from 440  ppb to 56 ppm.
     As in the case of fish and shellfish, bioaccumulation also occurs in
human adipose tissue.  Thus, fat appears to be the most significant tissue
to study  in this program since it serves as a sink for halogenated  hydrocar-
bons and  possibly represents a means of backward extrapolation of human
exposure  to halogenated hydrocarbons.

                                     43

-------
Table 7-2.  LEVELS OF HALOGENATED ORGANIC COMPOUNDS IN HUMAN SERUM,  PLASMA AND BLOOD
                                IN THE UNITED STATES
Compound
d-BHC
3-B11C



Y-BHC

Total BHC


£,£(-DDD



o>,£*-DDE


£,£'-DDE








Sample
Matrix
Serum
Male blood
Female blood
Serum
Blood
Male blood
Female blood
Female plasma
Female serum
Female serum
Male blood
Female blood
Female blood
Serum
Male blood
Female blood
Female plasma
Male blood
Female blood
Serum
Female plasma
Female serum
Female serum
Serum
Serum
Blood
Mean
(ppb)
<0.1
6.0
.2,2
0.1
1.4
1.5
1.4
3.4
1.6
1.7
18.9
7.9
<0.1
0.2
2.2
1.0
<0.1
17.8
8.8
11
13
39.5
40.6
17.6
22
15.7
Range Number of
(ppb) Determinations Location
0-15
1.3-20.3
0.3- 3.5
0-15
S.D.= 0.46
0.5- 8.0
0.7- 1.0
1.4- 9.6
0-10.2
0-2.9
5.7-44.8
3.2-15.0
<0.1
0-27
<0.3- 8.5
<0.3- 2.5
<0.1
6.2-36.7
6.8-10.7
5 -22
5 -20.3
6.1-114
13.2-60.5
-
0-383
S.D.= 6.5
1000
10
10

?
10
10
10
28
7
10
10
10
1000
10
10
10
10
10
38
10
28
7
970
782
?
ID
US
US
ID
FL
US
US
US
TX
Houston, TX
•US
US
US
ID
US
US
US
US
US
Hooper Bay, AK
US
TX
Houston, TX
UT
ID
FL
Reference
7.7, 7.8
7.9
7.9
7.8
7.10
7.9
7.9
7.9
7.7
7.7
7.9
7.9
7.9
7.8
7.9
7.9
7.9
7.9
7.9
7.8
7.9
7.7
7.7
7.13
7.8
7.10
                                     (continued)

-------
Table 7-2 (cont'd.)
Compound
DDE Blood
Plasma
Plasma
Plasma
Plasma
Serum
Serum
Serum,
Serum,
Blood
Sample
Matrix
, white children
, black children
, white adults
, black adults
children
adults
j>,£'-DDT Male blood
Female
Female
blood
plasma
p,p'-DDT Male blood
Female
Female
Serum
Serum
Blood
DDT Blood
Serum
Serum,
Serum,
Serum,
Serum,
Serum
Serum
Serum ,
Serum,
Blood
blood
plasma





white children
black children
uhite adults
black adults


children
adults

Mean
(ppb)
29.
24.
55.
28.
122
15.
13
13.
20.
11.
8.
3.
0
24
13
5
3
4
4.
8.
<2
6.
18.
11.
26.
4.
3
3.
6.
<7.


.
.
.
.
1
6
2
5
7
4
9
3
2
3
7
a
1
3
8
2
18
4

6
5
2
3
2

6
6
0











Range Number of
(ppb) Determinations Location
2 -54
1.4-33.6
1.6- 6.5
0.1- 1.1
6.8-84.4
5.7-19
2.6- 9.5
-
0-42
S.D.- 1.83
_
<2- 3
-
-
-
-
-
-
-
-
-
37
96
96
119
10
10
10
10
10
10
970
978
?
372
378
96
96
-
-
-
-
-
-
119
Tucson, AR
SC
SC
SC
SC
FL
ID
UT
UT
Miami. FL
US
US
US
US
US
US
UT
ID
FL
Tucson, AR
Hooper Bay, AK
SC
SC
SC
SC
FL
ID
UT
UT
Miami, FL
Reference
7.14
7.15
7.15
7.12,7.
7.12,7.
7.12
7.12
7.12
7.12
7.13.7.
7.
7.
7.
7.
7.
7.
7.
7.
7.
7.
7.
7.
7.
7.12
7.12
7.
7.
7.
7.
7.13
9
9
11
9
9
11
13
8
10
14
12
15
15
.7.
,7.
12
12
12
12
,7-
15
15
16













15
15




16
   (continued)

-------
                                               Table 7-2 (cont'd.)
ON
Sample Mean Range Number of
Compound
Total DDT
Dleldrln





Matrix (ppb) (ppb) Determinations
equlv. Female plasma 20.0 6.8-29.5
Male blood 5.5 1.0-12.9
Female blood 1.8 0.6-4.5
Female plasma 0.3 0.1-1.2
Female serum 1.2 0-6.0
Female serum 1,5 1.3-6.0
Serum 0.9
10
10
10
10
28
7
970
Serum 0.4 0-25 1000

Blood 1.49 S.D.- 1.00
Heptachlor Epoxlde Male blood 2.3 <0. 3-12.0


Female blood 2.2 0.5-5.1
Female plasma 0.6 0.3-1.0
?
10
10
10
Serum <0.1 0-5 1000
PCB's

NOTES :
BHC
DDD
DDE
DDT
Total
PCB's

T
ND
NQ
Plasma (refuse workers) 2.6 ND-14.1
Plasma (controls) 3.7 ND-20.2

= benzenehexachloride (hexachlorocyclohexane)
2 , 2-bis (chlorophenyl) -1 , 1-dlchloroethane
l,l-dichloro-2,2-bis (chlorophenyl) e thy lene
1,1, 1- trlchloro-2 , 2-b±s (chlorophenyl) ethane
37
54





DDT equiv. = Sum of all DDT-related peaks calculated as
Polychlorlnated blphenyls. Quantltation generally
an Aroclor mixture
Trace
Not detected
= Not quantitated




Location
US
US
US
US
TX
Houston, TX
UT
ID
FL
US
US
US
ID
US
US





Reference
7.11
7.9
7.9
7.11
7.7
7.7
7.13
7.8
7.10
7.9
7.9
7.11
7.8
7.10
7.10





if all were DDT
based on




comparison to





-------
Table 7-3.  LEVELS OF 1IALOGENATED ORGANIC  COMPOUNDS  IN  HUMAN MILK
                      IN THE UNITED STATES
Compound
|3- BMC

Y-BUC
Total D1IC


£,£'-DDD


o(£'-DDE
£,£'-DDE





DUE




Sample
Matrix
Milk
Milk
Milk fat
Milk
Milk
Milk
Milk
Milk fat
Milk
Milk
Milk
Milk
Milk
Milk
Milk fat
Milk
Milk
Milk
Milk
Milk
Milk
Mean
(ppb)
0.5
-
83
6.5
7.7
6.2
4.7
10.8
-
1.0
227
29
84.1
92.4
1766
-
194
60
30
30
100
Range Number of
(ppb) Determinations Location
T- 10
T- 38
30 - 270
0.1- .70.2
0- 37.0
3.6- 9.0
<0.1- 14
NO- 30
T- 5
<0.1- 2.8
10 -1720
5.2- 981
13.4- 236
16.7- 138
790 -4350
79 - 3J6
74 - 314
20 - 90
<10 - 140
-
70 - 120
57
40
53
14+
28
7
14+
53
40
14+
57
14+
28
7
53
40
30+
4
5
1
A*
AR, MS
CO
PA
US
TX
Houston, TX
US
PA
CO
US
AR, MS
US
TX
Houston, TX
PA
CO
AZ
Chicago. IL
WA
Phoenix, A2
US
Reference
7.17
7.18
7.19
7.11
7.7
7.7
7.11
7.19
7.18
7.11
7.17
7.11
7.11
7.7
7.19
7.18
7.20
7.21
7.21
7.21
7.21
                                (continued)

-------
                                               Table 7-3 (cont'd.)
Co
Sample
Compound Matrix
o,£'-DDT Milk
Milk
Milk
Milk
£,£V-DDT Milk
Milk
Milk fat
Milk
DDT Milk
Milk
Milk
Milk
Milk
Milk

Total DDT equiv. Milk
Milk
Milk
Milk
Milk
Milk
Milk
Milk
Milk
Milk (black)
Milk (white)
Milk
Milk
Milk
Mean
(ppb)
92
25
10
-
29
114
513
-
100
60
60
70
-
130

334
70.5
100
170
180
220
170
150
180
447
75
323
130
370
Range Number of
(ppb) Determinations Location
10 - 840
0.1- 10.8
5-36
T - 13
7.8- 89
- 9 - 383
, 90 -2120
7 - 109
80 - 130
<10 - 220
-
50 - 90
10 - 110
0-770

20 -2760
40.4- 156
S.D.- 100
S.D.- 130
.. S.D.- 100
S.D.- 170
S.D.- 150
S.D.- 80
' S.D.- 120
59 -1899
15 - 133
185 - 721
0- 770
0- 370
57+
U+
30+
40
<
30+
53
40
4
5
1
**
40
32

57+
14+
14
20
19
27
34
6
18
38
14
7
32
6
AR, MS
US
AZ
CO
US
AZ
PA
CO
Chicago, IL
WA
Phoenix, AZ
US
CO
DC

AR, MS
US
Long Island, NY
Rochester, NY
Chicago, IL
Lexington, KY
Nashville, TN
Memphis, TN
Los Angeles, CA
MS, AK
Nashville, TN
MS, AK
DC
CA
Reference
7.17
7.11
7.20
7.18
7.11
7.20
7.19
7.18
7.21
7.21
7.21
7.18
7.22

7.17
7.11
7.23
7.23
7.23
7.23
7.23
7.23
7.23
7.23
7.24
7.24
7.24
7.22
7.25
                                                   (continued)

-------
Table 7-3 (cont'd.)

Compound
Dleldrin




Heptachlor
Epoxlde


t-Nonachlor
Oxychlordane
I'CB's


NOTES :
BUG
ODD
DDE
DDT
Total DDT
PCB's =

rii 	
ND
NQ
_l> =
* /.-
A- =
Sample Mean Range Number of
Matrix (ppb) (ppb) Determinations Location
Milk - T - 50 57 AR, MS
Milk 6.2 2.9- 14.6 14 US
Milk 3.3 0- 21 28 TX
Milk 7.5 1.9-21 7 Houston, TX
Milk - T - 11 40 CO
Milk 4 T - 30 57 AR. MS
Milk 1.7 <0.1- 4.4 14 US
Milk fat 160 40 -460 53 PA
Milk - T - 5 40 CO
Milk 1 T - 10 57 AR, MS
Milk 5 T - 20 57 AH, MS
Milk T T - T 57 AR, MS
Milk M.O <40 -100 39 CO
Milk - 40 -100 40 CO

benzenehexa chloride (hexachlorocyclohexane)
2 , 2-bis (chlorophenyl)-l, l~dichloroethane
l,l-dichloro-2,2-bis (chlorophenyl) ethylene
1,1, l-trlchloro-2, 2-bis (chlorophenyl) ethane
equiv. = sum of all DDT-related peaks calculated as if all
polychlorinated biphenyls. Quantitation generally based on
to an Aroclor mixture
trace
not detected
not quantitated
5 women. Separate determinations make total of 14 samples
unspecified pool or donors in Denver and other US areas

Reference
7.17
7.7
7.7
7.7
7.18
7.17
7.11
7.19
7.18
7.17
7.17
7.17
7.26
7.18





were DDT
comparison






6 positive values out of unreported number of samples analyzed

-------
Table 7-4.  LEVELS OF HALOGENATED ORGANIC COMPOUNDS IN HUMAN TISSUE
                       IN THE UNITED STATES
Compound
a-BHC
B-B11C
Total BHC
ODD











£,£' -ODD
o,£'-DnE
£,£*-DDE •


Sample
Matrix
Fat
Fat
Fat
Ferirenal fat
Mesenteric fat
Panniculus fat
Bone marrow
Tracheobronchlal lymph nodes
Adrenal
Kidney
Liver
Brain
Gonad
Lung
Spleen
Fat
Fat
Adipose
Adipose
Fat
Mean
(ppb)
<30.0
600
480
11
47
18
76
10
57
2
33
2
2
0.9
3
450
290
5,000
2,400
6,850
Range
(ppb)
-
30-2,430
0-12,300
_
-
-
-
-
-
-
- _
-
-
-
-
90-990
50-530
-
-
560- 21,170
Number of
Determinations
25
25
994
30
29
30
19
11
18
38
42
32
36
25
27
25
40
103
959
25
Location
New Orleans, LA
New Orleans, LA
Chicago, IL
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu , HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
New Orleans, LA
New Orleans , LA
UT
Chicago, IL
New Orelans, LA
Reference
7.27
7.27
7.28
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.27
7.27
7.13
7.30
7.27
                            (continued)

-------
Table 7-4 (cont'd.)
Compound
DDE


















o,£'-DDT
jJ.p'-DIJT
DIJT







Sample
Matrix
Adipose
Adipose
Liver
Kidney
Brain
Perlrenal fat
Mesenterlc fat
Panniculus fat
Bone marrow
Tracheobronchial lymph nodes
Adrenal
Kidney
Liver
Brain
Gonad
Lung
Spleen
Fat
Adipose
Fat
Fat
Adipose
Adipose
Liver
Kidney
Brain
Perlrenal fat
Mesenteric fat
Pamilculus fat
Mean
(ppb)
5,790
A, 580
432
133
84
4,640
4,400
4,480
2,080
1,380
875
209
200
83
69
59
31
7,000
7,000
60
1,730
2,050
1,540
101
30
22
1,330
1,350
1,160
Range Number of
(ppb) Determinations Location
5
70
70
66
52
30
29
30
19
11
18
38
42
32
36
25
27
0-56,100 994
440-23,400 159
<10-670 25
150-5,990 25
5
70
70
66
52
30
29
30
Phoenix, AZ
Tucson, AZ
Tucson, AZ
Tucson, AZ
Tucson, AZ
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Chicago, IL
Miami, FL
New Orleans, LA
New Orleans, LA
Phoenix AZ
Tucson, AZ
Tucson, AZ
Tucson, AZ
Tucson, AZ
Honolulu, HA
Honolulu, HA
Honolulu, HA
Reference
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7.
7
7
7
7
7
7
7
7
7
7
.14
.14
.14
.14
.14
.29
.29
.29
.29
.29
.29
.29
.29
.29
.29
.29
.29
.28
13,7.16
.27
.27
.14
.14
.14
.14
.14
.29
.29
.29
    (continued)

-------
Table 7-4 (cont'd.)
Sample
Compound Matrix
DDT (continued) Bone marrow
Tracheobroncliial lymph nodes
Adrenal
Kidney
Liver
Brain
Gonad
Lung
Spleen
Fat
Adipose
Fat
Dieldrin Adipose
Adipose
Hair
Adipose
Ferirenal fat
Mesenteric fat
Tracheobronchial lymph nodes
Adrenal
Kidney
Liver
Brain
Gonad
Lung
Spleen
Fat
Adipose
Adipose
End r in Fat
Fat
Mean
(ppb)
411
892
125
83
47
10
15
14
11
2,600
4,300
5,300
210
140
^1
170
30
63
19
6
5.6
3.7
3.1
2.1
2.2
2.1
140
220
290
ND
<30
Range Number of
(ppb) Determinations Location
19
11
18
38
42
32
36
25
27
0-19,000 994
490-32,800 159
0-34,000 75
5
70
<10-10 9
103
30
29
19
11
18
38
42
32
36
25
<10-1,390 221
<50-770 146
30-1,150 25
221
25
New Orleans, LA
New Orleans, LA
New Orleans, LA
New Orleans, LA
New Orleans, LA
New Orleans, LA
New Orleans, LA
New Orleans, LA
New Orleans, LA
Chicago, 1L
Miami, FL
CA
AR, MS
Tucson, AZ
Raleigh, NC
UT
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Chicago, IL
Miami, FL
New Orleans, LA
Chicago, IL
New Orleans, LA
Reference
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.28
7.13,7.16
7.22
7.17
7.14
7.31
7.8
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.28
7.32
7.27
7.28
7.27
   (continued)

-------
                                                Table 7-4 (cont'd.)
CO

Compound
Hepcachlor














Mlrex
t-Nonach]or

PCU's





NOTES :
BUG
DDD
DDE
DDT
Total
PCB's

T
ND
Nil
*
Sample
Matrix
Epoxide Perlrenal fat
Mesenteric fat
Pannlculus fat
Bone marrow
Tracheobronchial
Adrenal
Kidney
Liver
Brain
Gonad
Lung
Spleen
Fat
Fat

Adipose
Adipose
Adipose
Hair
Adipoae
Adipose
Adipose
Adipose
Hair

Mean Range
(ppb) (ppb)
22
32
27
4
lymph nodes 0.1
1.2
0.9
1.9
0.2
0.1
0.3
T
160 <10-750
240 30-1.450

2,500 160-5,940
40
60
270 ND-760
470,000 204,000-600,000
M.,000
100,000
^1,000
ND

Number of
Determinations
30
29
30
19
11
18
38
4
32
36
25
27
505
25
*
6
5 (comp)
11
9
2
637
1
196
91


Location
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Honolulu, HA
Chicago, IL
New Orleans , LA

US
MA
TX
Raleigh, NC
US
US
MI
US
US


Reference
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.29
7.28
7.27

7.33
7.34
7.34
7.31
7.35
7.36
7.37
7.37
7.10

= benzenehexachloride (hexachlorocyclohexane)
2, 2-bis (chlorophenyl)-l, 1-dichloroethane
1 , l-dichloro-2 , 2-bis (chlorophenyl) ethylene
1,] , 1-trichloro-
DDT equiv. = sum of
poly chlorinated
mixture .
= trace
= not detected
not quantitated
2 , 2-bis (chlorophenyl) ethane
all DDT-related peaks calculated as
biphenyls. Quantitation generally





if all were

DDT
based on comparison to an










Arochlor




6 positive values out of unreported number of samples analyzed

-------
HALOGENATED HYDROCARBONS IN ENVIRONMENT OF NIAGARA FALLS/BUFFALO, NY AREA
Ambient Air
     The occurrence of halogenated hydrocarbons in the vapor phase of
ambient air was tabulated using information from other research programs as
well as environmental monitoring conducted under Phase I of this contract.
The sampling locations for the Niagara Falls and Buffalo areas, sampling
protocols and detailed information on the levels of halogenated hydrocarbons
are given in Appendix A.  Table 7-5 summarizes this information.  Listed is
the concentration range for the halogenated hydrocarbons which were detected
in the ambient air samples taken from this area, as well as the frequency
of detection and number of determinations.  Their percent occurrence in
ambient air was also calculated.  It is evident that a number of halogenated
hydrocarbons are occurring with a high frequency at levels above 1000
    3
ng/m .  Also, a number of halogenated hydrocarbons appear to be site-
specific for this area since these substances were not identified in ambient
air in other geographical areas.  This factor will be further dicussed in
the summary section of this chapter.
Drinking Water
     Appendix A presents detailed information on sampling and analysis and
the data obtained for the concentrations of purgeable halogenated organics
in drinking water from Niagara and Buffalo, NY.  Table 7-6 summarizes the
estimated levels of these compounds.  Many of the halogenated hydrocarbons
found in ambient air are also present in the drinking water from this area.
Table 7-7 presents additional information on halogenated organics and water
which has been reported in the literature.
Human Breath
     As part of the pilot study, limited sampling and analysis was conducted
in the human population in order to estimate the levels of halogenated
organics.   Samples were taken from individuals living in the ''Old Love"
Canal area to determine the extent of human contamination.   Appendix A
presents the sampling protocols for -the human body-burden study.
     Table 7-8 lists a summary of the estimated levels of halogenated
organics in human breath for the Niagara Falls, NY area.

                                     54

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                  Table 7-5.   SUMMARY OF ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED ORGANICS
                                      IN AMBIENT AIR IN NIAGARA FALLS, NY
Ln
Chemical
chloroform
tetrachloroethylene
carbon tetrachloride
1,1,1-trichloroethane
chlorotoluene isomers
dichlorobenzene Isomers
dlchlorotoluene Isomers
trichlorobenzene isomers
trichlorotoluene isomers
chloro benzene
chloronaphthalene isomers
tetrachlorobenzene isomers
1 , 2-dibromoethane
1, 3-hexachlorobutadiene
dichlorobenzaldehyde isomer
tetrachlorotoluene isomers
1 , 2-dichloro ethyl ene
1 ,2-dichloroethane
C r ichloroe thylene
1, 2-dichloro pro pane
chlorobenzotrif luoride isomers

Cone. Range
(ng/m3)
1,050-105,461
122-14,000
T-3,692
1,444-5,444
T-12,274
T-444
T-648
T-4,346
T-568
T-119
T
T-451
T
T-389
T
T
T
T
285-611
T
410-19,586
(continued)
Frequency
Detected
9
9
8
8
12
7
10
10
10
5
5
8
4
6
3
3
3
2
2
2
3

No. of
Determinations
9
9
9
9
15
9
15
15
15
9
9
15
9
15
9
9
9
8
9
9
15

Percent
Occurrence
100
100
89
89
80
78
67
67
67
55
55
53
44
40
33
33
33
25
22
22
20


-------
                                             Table 7-5 (cont'd.)
Ln
Chemical
dichlorobenzotr If luorlde
bromo toluene Isomer
bromochlorotoluene Isomer
pentachlorobenzene
1 , 1-dichloroethane
chlorobenzaldehyde
chlorobenzodlchlorof luorlde
isomer
1, 2-bis- (trif luoromethyl)benzene
Cone. Range
(ng/m3)
193
T
T
17
ND
NDa
NDa
Frequency
Detected
1
1
1
1
0
0
0
0
No. of
Determinations
6
9
9
15
9
9
9
9
Percent
Occurrence
17
11
11
7
0
0
0
0
        Previously Identified  In  household  basements In "Old Love" Canal,  see reference 7.60.

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Table 7-6.  SUMMARY OF ESTIMATED LEVELS OF PURGEABLE HALOGENATED ORGANICS IN
                DRINKING WATER FROM NIAGARA AND BUFFALO, NY
Chemical
bromodlchloromethane
tetrachloroethylene
1,1, 1-trichloroethylene
chlorobenzene
m-dichlorobenzene
chloroform
carbon tetrachloride
bromof orm
chlo rod Ibromome thane
trichloroethylene
trichlorobenzene isomers
teCrachlorobenzene isomers
1 , 3-hexachlorobutadiene
o-dichlorobenzene
chlorotoluene isomers
1 , 2-dichloropropane
Cone. Range
(ng/4)
1,758-10,375
350-2,875
8-417
8-58
8-700
4,433-39,625
16-192
16-60
75-6,767
8-253
325-542
125-1,958
T-167
56-125
T
T
Frequency
Detected
15
15
15
15
15
14
14
13
13
13
11
8
6
5
2
1
No. of
Determinations
15
15
15
15
15
15
15
15
15
15
15
15
14
15
15
14
Percent
Occurrence
100
100
100
100
100
93
93
87
87
87
73
53
43
33
13
7

-------
                                  Table 7-7.   LEVELS  OF HALOGENATED ORGANICS  FOUND IN WATER
                                                    IN THE BUFFALO/NIAGARA AREA
CO
Chemical
Hethylene Chloride
Chloroform
Dibromochlorome thane
Bromodichlorotne thane
PCB's
DDE
DIeldrin
DDD
DDT
£-Dlchlorobenzene
b c
Cone. Range Cone, Mean
((Jg/i) (|Jg/£)
5
3.1
0.6
0.5
0.0705
0.0203
0.0043
0.0040
0.0035

Number of
Determinations
1
3
2
2
2
2
3
2
2

References Production Data (million Ib./yr.)
7.38
7.39
7.39
7.39
7.40
7.40,7.41
7.40
7.40
7.40
ICC Indust., Inc., Niagara Falls,
          Chlorobenzene
          Chlorotoluene
(7),  Solvent Chem. Corp., Niagara
Falls (10).


6ICC  Indust., Inc., Niagara Falls
(0.02); Solvent Chem., Corp.,  Inc.,
Niagara Falls; Occidental Petroleum
Corp., Niagara Falls  (0.015)

o- and £- isomers:  Hooker Chem.
Corp., Niagara Falls
                                                              (continued)

-------
                                       Table  7-7  (cont'd.)
Chemical
                             b           c
                    Cone. Range    Cone. Mean
            Number of
(pg/4)      Determinations   References  Production Data  (million Ib./yr.)
1,2,4-Trlchlorobenzene
Pentachlorobenzene
1,2.4-TrIchlorobenzene
Phosgene
                                   Solvent Chero.  Corp., Niagara
                                  Falls (1.5); Occidental
                                  Petroleum Corp., Niagara Falls (2).

                                   Occidental Petroleum Corp.,
                                  Niagara Falls.

                                   Occidental Petroleum Corp.,
                                  Niagara Falls.

                                  Van De Mark Chera.,  Co., Inc., Lock-
                                  port, NY (8).
 Buffalo/Niagara area includes sites in/at Iliap.ara River, Lake Ontario-olcott, Marrero,
 Buffalo, Dunkirk, Niagara.

 Cone, range  omitted where  none was cited, or  where individual pieces  of data were  not  given,
 or where a  range cited  in  one reference was exceeded by a value reported in another  reference
 in which no  range was given.

'Cone, mean  is the arithmetic  average of concentration data, with  the  following limitations
 imposed by  the nature of  the  reporting:
   (1)  where no quantification was performed  the occurrence of  a  chemical was in no  way
        included in calculating the mean.
   (2)  where only one concentration was reported for an unspecified number of determination
        <(n)  and/or samples,  that concentration  was Included in  the calculation as  if only
        one determination had  been performed.
   (3)  where several concentrations were reported, each was included individually  in the cal-
        culation of the  mean.
   (4)  where an average value and the number  of determinations  <(n)  perfo'med were given, but
        individual values were not given, the  average value was  included n times in the  calcu-
        lation of the mean.
                                              (continued)

-------
                                      Table 7-7 (cont'd.)
 Number of determinations was calculated by adding, where given:
   (1)  the number of individual determinations performed (case C.3 and C.4 above).
   (2)  1 (one) for average values given where no number of determinations was given (case C.2
        above).

Unpublished data, Tracer Jitco, Inc., 1776 East Jefferson St., Rockville, MD  20852

-------
Table 7-8.  SUMMARY OF ESTIMATED LEVELS OF HALOGENATED ORGANICS IN HUMAN BREATH
                            IN NIAGARA FALLS, NY
Chemical
chloroform
1, 1,1-trichloroe thane
tetrachloroethylene
carbon tetrachloride
dichlorobenzene Isomers
1, 2-dlchloroethane
chlorobenzotrifluoride Isomers
1, 1-dichloroethane
trichloroethylene
chlorobenzene
chlorotoluene isomers
dichlorotoluene isomers
chloronaphthalene isomer
bromotoluene isomers
trichlorobenzene isomers
telrachlorobenzene isomers
pen Lac hi oro benzene
1, 3-hexachlorobutadiene
Cone. Range
(ng/m3)
3,896-94,510
T-394
658-1,753
T-796
T-5,294
T-243
T-852
T
T
T
261-338
1,220
T
T
T-88
27-180
73
T
Frequency
Detected
9
9
9
8
7
4
5
1
3
1
2
1
1
1
2
2
1
1
No. of
Determinations
9
9
9
9
9
9
9
9
9
9
9
9
9
9
9
9
9
9
Percent
Occurrence
100
100
100
89
78
44
55
11
33
11
22
11
11
11
22
22
11
11

-------
Human Blood
     In addition to human breath, blood samples were also acquired -from  the
same individuals in the "Old Love" Canal area.  The purgeable halogenated
organics were quantified in the blood samples and these data are shown in
Table 7-9.  The concentrations of many of the halogenated hydrocarbons
exceeded 1 ppb levels.
     Table 7-10 presents the pesticides which were measured in the same
human blood samples.  Virtually every sample contained p_,£'-DDE while a  few
samples may have contained heptachlor.
Human Urine
     Table 7-11 gives the levels of purgeable halogenated organics occurring
in human urine from the inhabitants of the "Old Love" Canal in Niagara-.-  • .
Falls, NY.  Many of the chemicals which were detected in breath and blood
were also detected in urine of these individuals.
HALOGENATED HYDROCARBONS IN ENVIRONMENT OF NEW JERSEY AREA
Ambient Air
     The sampling protocols and locations of sampling for ambient air in
the New Jersey area which was conducted under the pilot study of this
program, as well as under other research programs, are presented in Appendix
A.  Detailed data are also given in Appendix A.
     Table 7-12 presents a summary of the estimated levels of vapor phase
halogenated organics in the New Jersey area.  Many of the halogenated
hydrocarbon levels exceeded the ppb level and represented the highest
values observed in the ubiquitous category when compared to the other five
geographical areas.  The ubiquitous compounds were detected at high frequen-
cies .
Drinking Water                               '
     Table 7-13 presents the levels of purgeable halogenated organics which
were found in New Jersey drinking water samples.  The leve'.s of these com-
pounds were also relatively high as compared to water in other geographical
areas.  Furthermore, they occurred at a high frequency rate.
     Table 7-14 presents the levels of halogenated organics found in water
in the New Jersey area which was information acquired from other research

                                     62

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          Table  7-9.   SUMMARY OF ESTIMATED LEVELS OF PURGEABLE HALOGENATED ORGANICS IN HUMAN BLOOD SAMPLES

                                                IN NIAGARA FALLS, NY
en
OJ
Chemical
chloroform
1,1, 1-trichloroe thane
tetrachloroethylene
m-dichlorobenzene
carbon tetrachloride
trichloroethylene
chlorobenzene
o-dlchlorobenzene
bromodiclilorome thane
tetrachlorobenzene
Cone. Range
(ng/£)
1,100-20,100
250-2,000
22-255,550
600-67,700
40-140
100-2,550
50-16,800
150-350
14,250
2,600
Frequency
Detected
9
9
9
9
8
6
8
5
1
1
No. of
Determinations
9
9
9
9
9
9
9
9
9
9
Percent
Occurrence
100
100
100
100
89
67
89
55
11
11

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            Table  7-10.  HALOGENATED EXTRACTABLE (SEMI-VOLATILES) IN HUMAN BLOODa


                                               Compounds, ng/1 (ppt) Whole Blood

                                        Heptachlor
Sample  Trifluralin  a-BHC  Heptachlor   Epoxide    Endosulfan  Dieldrin  £,£!-DDE  £,£'-DDT  Mirex

  1                           1610         -            -                   3035

  2                                        -            -                   2990

  3                                        -            -                   2040
4

5
6
8
9

10
1070 - - - 925 -
h
1335 - - 800
- - - 935
630C - - 1440
- - - - 800
h
- - - 1370D
a20 ml whole blood diluted to 50 ml with distilled water.  Control:  0.52 pg ct-BHC.   35.2 + 4.4%
 recovery (two Injections of both standard and extract).  Chromatography Cleanup:  0.18  pg a-BHC.
 99.8 + IV 'i% recovery from Florlsll  (two Injections of both std. and extract).  Sensitivity:
 5-205~ng/£, - = not detected.
 Compound discovered after Florisil cleanup.  Interferences due to peak overlap, low  sensitivity,
 etc.
Unconfirmed.  Large peak overlap.

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                    Table 7-11.  SUMMARY OF ESTIMATED LEVELS OF PURGEABLE HALOGENATED ORGANICS
                                       IN HUMAN URINE FROM NIAGARA FALLS, NY
ON
Cn
Chemical
chloroform
tetrachloroethylene
chlorobenzene
carbon tetrachlorlde
1,1,1-trichloroe thane
trlchloroethylene
m-dichlorobenzene
o-dlchlorobenzene
1 , 2-dichloroethane
chlorotoluene isomer
bromotoluene isomer
Cone. Range
(ng/A
858-1,460
120-550
50-117
42-150
92-183
42-400
36-39,160
108-725
50-75
T
T
Frequency
Detected
9
9
6
9
4
9
6
3
2
1
1
No. of
Determinations
9
9
9
9
4
9
9
4
9
9
9
Percent
Occurrence
100
100
67
100
100
100
67
75
22
11
11

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Table 7-12.  SUMMARY OF ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED ORGANICS
             IN THE NEW JERSEY AREA
Chemical
tetrachloroethylene
trichloroethylene
chlorobenzene
m-dichlorobenzene
1,1,1-trichloroe thane
1 , 2-dichloroethane
o-dichlorobenzene
chloroform
carbon tetrachloride
vinyl chloride
trichlorobenzene
1 , 2-dichloroethylene
1,1, 2-trichloroethane
1,1,2, 2-tetrachloroethane
1 , 1-dichloroethane
Concentration Range
(ng/m )
T-394,000
T-173,886
T-6,072
T-3,392
T-111,167
T-139,121
T-12,433
T-98,625
T-42,378
T-3,132
33-1,160
T-5,263
294-17,571
T-2,872
T-342
Frequency
Detected
85
86
85
90
83
75
84
78
83
15
27
4
7
4
10
Number of
Determinations
86
87
86
93
86
93
93
87
93
36
96
16
36
26
66
Percent
Occurrence
99
99
99
97
96
81
90
90
89
42
28
25
19
15
15

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Table 7-13.  SUMMARY  OF ESTIMATED LEVELS OF  PURGEABLE HALOGENATED ORGANICS  IN
             NEW  JERSEY DRINKING WATER
Chemical
1,1 ,1-trichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
bromodichlorome thane
chlorodibromome thane
chlorobenzene
m-dichlorobenzene
o-dichlorobenzene
1 ,1-dichlorobenzene
trichlorobenzene isomers
Concentration Range
(ng/A)
64-2,667
77-575
757-18,017
86-1,183
624-146,150
274-92,592
T-75
T-25
17-50
105-142
50
Frequency
Detected
22
22
22
22
22
22
20
20
12
3
1
Number of
Determinations
22
22
22
22
22
22
22
22
22
22
22
Percent
Occurrence
100
100
100
100
100
100
91
91
55
14
5
                                                                                             t >

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                  Table 7-14.   LEVELS OF IIALOGENATED ORGANICS FOUND IN WATER  IN  THE  NEW JERSEY AREA
00
Cone. Range
Chemical (|ig/l)
Dlchlorobenzene
Trie hlo roe thane
Dteldrin 29.0 - 4.0
Chloroform
Chloronltrobenzene
Trichloroetbylene
Dlchloroe thane
Methyl Trichlorophenoxyacetate
Bromodlchloroe thane
Bromod-lchloromethane 16.0 - n.d.
Tetrachloroethylene
Methyl Dlchlorophetioxyacetate
Dlbromochloromethane
Bromopropylbenzene
Bromobenzene
Methylene Chloride
Tetrachlo roe thane
Met hy 1-2- (4-Chlorophenoxy)bucanoate
Bromochloroerh, e
Dlchloroe thylene
Bromochloropropane
Pentachloroanlsole
Dlchloropropane
Com- . Mean
209
42.0
19.7
14.5
10.7
7.0
5.0
5.0
5.0
3.7
3.6
3.5
3,3
3.0
3.0
2.5
2.5
2.0
2.0
1.8
1.5
1.3
1.3
Number of
Determlna t Ions
6
11
4
5,6
3
33
27
1
2
16
23
: 2
9
1
1
8
13
1
2
5
2
'~ 4
4
References Production Data (million Ib/yr)
7. IN Standard Chlorine Chem. Co., Inc., Kearny
(o-isomer (16); 0-isomer (n.d.).]
7.38,7.39,7.43
7.38
1.1,2
7,'JH
7.38,7.35,7.43
7.38,7.44,7.45
7-lfi
7.38
7.38,7.39,7.45
7.38
7. 311
7.38,7.33,7.43,7.45
7.311
7. 38
7.38




7.1.'!
7.18
7. 30
                                                     (continued)

-------
Chemical
lie Kachloroe thane
Tr Ichlo roan i sole
Ch 1 orobenzene
01 chlorolodome thane
Carbon Tetrachlorlde
llexachlorobutadlene
Bromoform
£-Chloro toluene
o-Chloro toluene
Cone. Range Cone. Mean Number of
(ug/ i) (pg/t) Determination References Product ion Data (ml 11 ion Ib^yr)
1.0 l ' 7 . 3H
1.0 2 7-38
1-0 1 7.38
1.0 1 ?.3fi
7. 38.7.39, 1. AJ
<2.0 - n.d. 1.0 6 1 t L 1 L\
0.7 3 7- h'i.7.46
0.6 fl 7.1?!, 7. 39, 7. 45
Tenneco, Inc. , Fords
Tenneco, Inc . , Ford a (9) ; Monsanto, Bridgeport
0\
                  Benzyl Chloride
                  Phosgene
(80); Stauffer Chan. Co., Edison (11); used by
UOPi Inc.. East Rutherford (5).

Monsanto, Bridgeport (80); Stauffer Chen, Co.,
Edison (11); Tenneco, Inc., Forda (9), used by
UOP, Inc., East Rutherford (5).

E.I. duPont de Nemours, Deepwater Point  (133).
                   New Jersey includes aites in/at Reedy  Island, Turnpike  Bridge, Paasalc  River  mouth,  Port  Elizabeth,  Bayonne,  Linden,  St.  John,  Delaware Memorial
                   Bridge, Marcua Hook, Pauldboro, Navy Yard, Tremley, Newark, Narrows, Lower  Bay,  Ifudaon  River mouth.  Fort  Lee,  Little  Falla,  Ben Franklin Bridge,
                   Racltan Bay, Perth Amboy, Sewaren, Tufts, Pasaaic County,  Bristol, Torresdale,  Phillipsburg, llauorth.  Clifton, Rahvay. Colonic, Delaware River mouth
                   French town . 1: lisa be tit town,  lie a ex County , Kingstown, Shrewsbury ,  Woodbr ld(*£, Suffolk  City,  Toms  River ,  and East on,  PA.

                   Cone, range omitted where none was cited, or where individual pieces of data  were not given, or where  a  range  cited in one reference was exceeded
                   by a value reported In another reference in which no  range was given.

                  ""Cone. mean io the arithmetic average of concentration data, with the following  limitations  imposed by  the nature of the report ing;

                             1.   where no quantification  was performed,  the  occurrence of  a  chemical was in  no way included
                                 in calculating the mean.

                             2.   where only one concentration was  reported for an unspecified  number "of determinations  <(n)  and/or
                                 aampl.es, that concentration was included  in the calculation as  if  only one  determination had been
                                 pc rformed.

                             3.   where several concentrations were reported,  each was included Individually  in the calculation of
                                 the mean.

                             4.   where an average value and thu number of  determination <(n) performed  were  given, but  Individual
                                 valueti were not given, the average value  waa included 11  times In  the calculation  of  the  mean.
                  j
                   Niim bur of dutermi nat ions was ca leu 1 a ted by adding, where  g 1 van :

                             1)   the number of indIvidual determlnat(ons performed  (case  C3  anil  CA  above).
                             2)   t (one)  for average  wi lues gi vi-o  whe re  no number of dt.'lerinl nat Ions was g I vrn.  (c;me C2  above) .

-------
programs.  These data are comparable to those presented in the previous
table.
     Table 7-15 presents the analysis of extractable halogenated hydrocarbons
in tap water from northern New Jersey.   These water samples are the same as
those presented in Table 7-13.  In contrast to the data in Table 7-13 for
purgeable halogenated hydrocarbons, essentially none of the pesticides were
detected in these drinking water samples.
HALOGENATED HYDROCARBONS IN ENVIRONMENT OF BATON ROUGE, LA AND VICINITY
Ambient Air
     Appendix A presents the sampling protocol and locations, as well as
the detailed information on the levels of vapor-phase halogenated organics
in ambient air from Baton Rouge, LA.  Table 7-16 presents a summary of
these estimated levels.  Substantial quantities of the ubiquitous compounds
were observed, as well as the presence of a new set of site specific pollu-
tants which were not detected in samples from other geographical areas.
Twenty-nine vapor-phase halogenated organics were identified and measured.
Drinking Water
     Table 7-17 presents a summary of the levels of purgeable halogenated
hydrocarbons found at the Jefferson Parish water plant.  Table 7-18 presents
additional information for halogenated hydrocarbons in tap water from
Jefferson Parish.  Finally, Table 7-19 presents the data for the New Orleans/
Baton Rouge, LA area.  In general, the purgeable compounds appear to be at
rather elevated levels while the pesticides are not detectable.
HALOGENATED HYDROCARBONS IN ENVIRONMENT AT HOUSTON, TX AND VICINITY
Ambient Air
     The sampling protocol and locations as well as the detailed information
on the vapor phase halogenated organics in ambient air for Houston, TX and
vicinity are given in Appendix A.  Table 7-20 presents a summary of the
estimated levels of these compounds.  The ubiquitous compounds comprise the
substances occurring at the highest frequency rate an? nighest concen-
tration values.  A series of site-specific pollutants  is also present which
represents essentially the production, storage, or usage of these compounds
in this area.  Data for 30 halogenated hydrocarbons are presented in this
table.
                                     70

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       Table 7-15.  QUANTITATIVE ANALYSIS OF EXTRACTABLE SEMI-VOLATILE HHC'S IN
                           TAP WATER IN NORTHERN NEW JERSEY3
Site
I
2
2
3
3
3
3
3
3
3
4
4
4
4
4
4
5
5
5
5
5
5
Period
2
3
4
6
6
6
1
1
1
a
a
a
a
a
a
a
10
10
10
10
10
11
Location
Trlfluralin
5
6
2
4
5
6
2
3
7
1
2
3
4
5
6
7
2
4
5
6
7
1
Conpound (ng/t.ppt)
a-BHC Heptachlor
.
_ -
_
- -
- -
- -
-
-
- -
-
-
-
_ -t
-
-
-
-
-
-
-
-
20
Heptaclilor Endoaulfan JP.g'-DDB Dleldrla
Epoxlde
-
— — _ —
- _ _
- _ _ _
— _ _ _
- _ _ _
-
- _ _ _
- - -
_ _ _
,.
_
_
_
_ _ _ _
_
-
_
_
-
_

E.J»'-DDT
_
_
_
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-

aSample size - 120 rai; Detection limit » 5-25 ng/8.
 See Tables 7-37, 7-38, 7-40, 7-41 and 7-42

-------
         Table  7-16.   SUMMARY  OF  ESTIMATED  LEVELS OF VAPOR-PHASE HALOGENATED ORGANICS
                                  IN BATON  ROUGE, LA AREAa
Chemical
chloroform
tetrachloroethylene
carbon tetrachloride
1 , 2-dlchloroethane
1,1, 1-trichloroethane
trichloroethylene
o-dichlorobenzene
m-dichlorobenzene
chloroethane
vinyl chloride
chloroacetylene
1 , 2-dichloropropane
1,1, 2-trichloroethane
1,1-dichloroethane
tetrachlorobutadiene
tetrachloropropane isomer
bis (2-chloroisopropyl)ether
chlorobenzene
hexachloro-1 , 3-butadiene
1 , 3-dichloropropene
tr 1 chloropropane
1,1,2, 2-tetrachloroethane
vinylidene chloride
dichloropropene
pen tachloroe thane
hexachloroe thane
pentachlorobutadiene
chloro toluene
trichlorobenzene isomers
Concentration Range
(ng/m )
181-11,742
7-1,224
T-10,100
9-10,341
T-8,760
T
T
T
1,378
T-1,334
T-58
T-3,999
36-9,611
T-500
T-139
13-242
T-363
T-900
18-37
T-10
T-24
T-1,573
T-990
106-261
T-13
T
T
35
ND
Frequency
Detected
42
40
37
36
33
3
3
3
19
9
5
15
13
12
3
3
3
10
2
2
2
7
6
2
2
2
1
1
0
Number of
Determinations
43
43
43
43
43
4
4
4
30
16
12
39
43
43
11
11
11
43
11
11
11
43
44
11
15
15
11
11
4
Percent
Occurrence
98
93
86
84
77
75
75
75
63
56
42
38
30
28
27
27
27
23
18
18
18
16
14
18
13
13
9
9
0
See reference 7.61 and 7,62.

-------
          Table 7-17.   SUMMARY OF PURGEABLE HALOGENATED HYDROCARBON LEVELS  FOUND AT
                         JEFFERSON PARISH WATER PLANT,  2/7/77  - 8/5/77
Detection
Limit
(Mg/A)
C-l, 2-dichloroethylene
dlchlorome thane
bromo ethane
carbon tetrachloride
chloroform
bromo chlorome thane
trichloroethylene
dichlorobromome thane
1 , 2-dichloroethane
dibromochlorome thane
1,1, 2-trichloroethane
chlorobenzene
bromo form
m-dlchlorobeivzene
.2
-
.3
1.0
.3
.7
.6
1.3
.5
2.5
1
.15
10.0
.5

Number
of
Times.
Found
0
52
0
12
52
0
24
1
52
16
13
5
0
1
River
Q
Mean
(vg/A)
-
2.581
-
0.69
1.245
-
0.20
0.0242
8.680
1.86
0.237
0.062
-
0.037
a
Low
Value
(Kg/A)
-
0.4
-
0.7
0.2
•
0.1
1.3
1.1
1.4
0.2
0.1
-
1.9

High
Value
(ug/A)
-
15.8
-
11.2
2.5
-
1.4
1.3
32.3
13.4
2.1
1.5
-
1.9

Number
of
Times
Found
0
51
0
8
52
1
15
18
52
19
18
4
0
2
Sand
c
Mean
(Mg/A)
-
3.848
-
0.395
10.008
0.010
0.087
0.990
8.014
1.63
0.223
0.027
-
0.039
Filter3
Low
Value
(Mg/A)
-
0.3
-
0.8
1.8
0.5
0.2
0.5
1.1
0.2
0.3
0.1
-
0.1

High
Value
(Mg/A)
-
18.1
-
8.0
46.0
0.5
0.5
6.2
23.7
12.8
1.6
0.8
-
1.9
 River  =  untreated Mississippi River water.   Sand Filter  =  water  entering  distribution  system.
^Number of  items given compound found at level greater  than detection  limit.
'Arithmetic mean for 52 samples,  with zero  used as value  for concentrations below the detection limit.
 Some values reported below detection limit.

-------
         Table  7-18.  SUMMARY OF PURGEABLE HALOGENATED HYDROCARBON LEVELS FOUND IN TAP WATER


                                       IN JEFFEUSON PARISH3
Compound
1 , 2-dichloroethylene
dichlorome thane
bromoethane
carbon tetrachloride
chloroform
bromochlorome thane
trichloroethylene
dichlorobromome thane
1, 2-dichloroethane
dlbromochloromethane
1,1,2-trichloroethane
chlorob^nzene
broroofonn
dlchlorobe'i~ene
tetrachloroetbylene
Source: Private communication, N. V.
Number
of
Times .
Found
1
117
0
145
145
5
92
141
145
63 i
87
0
0
0
114
Brodtmann,
Low
c
Mean Value
(ug/£) (ug/Jt)
0.0007
0.13
_
0.20 0.03
6.06 0.9
0.089
0.19
1.74
2.16 0.6
0.20
0.12
_
.
-
o.i4
Jr.; Jefferson Parish Department
High
Value
(Mg/0
0.1
1.1
-
2.5
86.1
7.5
1.6
14.0
8.1
3.5
2.4
-
-
-
1.1
of Water,
          Jefferson, LA, May 1978.



 Number of times given compound round out of 145 samples.
r»

 Arithmetic mean for 145 samples, with zero used as value for concentrations below


 detection limit.
the

-------
NEW ORLEANS/BATON ROUGE AREA
Chemical
t rlchloroelhylene


chloroform


bromobenzene
trlchloroethane


dlchloroethane






carbon tet rachlorlde


dlchlorobenzene

at razlne
dlchloroethylene
methylene chloride

chlorodlbromofne thane


alaclilor (2-C1 homolog)
bromod ichloromethane


tetrachloroeLhyltiiie
, Number of
Cone. Range (Mg/t) Cone. Hean (Mg/*) Determinations References
5227-n.d. 96 66 7.38,7
7.48,7

394-0.2 20 73 7.38,7
7.48.7
7.45,7
13 1 7.38.7
334-0.235 10.6 68 7.47,7,
7.49,7.

32.3-n.d. 7.7 61 7.38,7,
7.47,7.





193-<,1 7.1 67 7.47,7.
7.49,7.
7.52
15-n.d. 4.2 >55 7.38.7.
7.52
4.2 4 7.38,7,
4 1 7.38
15.8-0.34 2.6 53 7.47,7.
7.52
15.0-n.d. 3.5 58 7.38,7.
7.47.7.
7.55
2.9-1.9 2.3 3 7.52
2.2 60 7.38,7.
7.47.7.
7.52,7.
7-0.2 1.9 6 7.38,7.
.47,
.49

.47.
.49.
.51
.54
.48
.52

.45
.52





48
51,

47.

,52

51.

45,
52,


45
51
55
52
Production Data (million Ib./yr.)
Ethyl Corp., Baton Rouge (50);
Occidental Petroleum Corp., Taft
(40)




1 . 1,1-trichloroethane; Vulcan
Materials Co., Celtimar (65);
Ethyl Corp., Baton Rouge (40)
1,2-dichloroethane: Allied Chem.
Corp., Baton Rouge (300); Borden,
Inc., Gelamar (300); Dou Chem.,
Plaquemlne (450); Ethyl Corp.,
Baton Rouge (330); Monochem. Inc..
Celsmar (300); Shell Chem. Corp.,
Norco (700)







Dow Chem.. Plaquemlne (190);
Vulcan Materials Co.. Celsmar (80)







Ethyl Corp., Baton Rouge (50);
                                    Vulcan Materials Co.. Ceismar
                                    (150); Dow Chem., Plaquemlne
                                    (150); Occidental Petroleum
                                    Corp., Taft (50)
(continued)

-------
                                                   Table  7-19  (cont'd.)
(T>
Chemical Cone. Range (|Jg/t)
hexachlo roe thane
dichlorolodome thane
hexachlorobutadiene
dibromochlorome thane
chloral
alachlor (1-C1 homolog)
deethylatrazlne
trlchloropropane
dibromodlch lor oe thane
chlorobenzene
bromoform
cyanazlne
vlnylldene chloride
bis (2-chloroisopropyl) ether
blo{2-cnloroe thy 1) ether
slmazine
propazlne
tetrarhloroe thane
heptach l.oronorbomene
dleldrln
butachlor
4.3-0.19
1.6-1.1
4.7-n.d.


1.7-0.5
0.80-0.75

0.63-n.d.

0.57-n.d.
0.35-0.21

0.18-0.03
0.16-0.04


0,11-n.d.
0.07-0.04
0.07-n.d.
0.06-0.05
Cone. Mean (pg/O
1.6
1.3
1.2
1.0
1.0
0.88
0.78
0.4
0.32
0.30
0.25
0.29
0.2
0.10
0.11
<0.1
<0.1
0.04
0.06
0.02
0.05
Number of
Determinations References Production D.-iln (million Ih./yr.)
3
3
16
1
9
3
3
10
3
53
4
3
2
3
3
3
3
3
6
9
3
7.
7.
7, W,
7.
. 7.
7.
7.
7.38,
7.
7.47,
7.45,
7.
7.
7.
7.
7.
7.
52
52
7.53
51
55
52
52
7.52
52
7.51
7.52
52
56 Dow Chem. , Plaquemlne
52
52
52
52
7.52
7.52
7.42,7.52
7.52
                                                        (continued)

-------
                                                      Table  7-19  (cont'd.)
Chemical
DOE
chlordane
ptsntachlorophenyl methyl
pentachloroethane
DDT
endrln
PCB'a
ehloronl t robenzene
b romochlorobenzene
trlchlorotrlfluoroethane
dlchloropropane
bis (chloroiaetbyl) ether
a Id rln
chloroDie thane
chloropyridlne
llndane
benzene hoxach lor Ida
vlny 1 chloride
Cone. Rangeb 3


1

32


1


References Production Data (million Ib./yr.)
7.52
7.52
7.52
7.52
7.42
7.52
7.40
7.54,7.52
7.54
7.51
7.56
7.54
7.57
7.54
7.54
7.57
7.57
7.58 Allied Ctiem. Corp., Baton Rouge (300);
                                                                                                  Borden, Inc., Gelauar (300);  Dow Chem.
                                                                                                  Plaquemlue (450); Ethyl Corp., Baton
                                                                                                  Rouge (330); Monochem., Inc., Celamar
                                                                                                  (300); Shell Chem.  Corp., Norco (700).
dlchloroacetylene
                                                                                    7.54
                                                           (continued)

-------
                                                           Table  7-19  (cont'd.)
Chemical
dlbromobenzene
dichlorobutene
hexachlorobenzene
cyanogen chloride
hexachlorocyclohexane
Cone. Range (|i(;/
n.q.
n . <| .
n.q.
n.q.

Number of .
(,) Cone. Mean (iJR/P.) Determinations References Production l):il.-i (million lh./yr.)
7. 54
7.54
7.54
7.54
Shell Chem. Co., Norco (60).
aBaton Rouge/Hew Orleans area includes  sites  In  New Orleans, Luling, Jefferson P.-irisb, Cnrrollton,  Terrebonne  Parish, Morgan City, Lafayette,
 Head of Passes, Port Sulphur, Lutcher,  Plaquemlne, Geismar, tlahnvllle. Baton Rouge, Mississippi River,  Baton  Rouge - Port Sulphur transect.

 Cone, range omitted where none was cited,  where individual data were not given, or where range cited In one reference was exceeded by a value
 reported In another reference in which  no  range was  given,
°Conc. mean Is the average of concentration data, with  the following limitations:
     (1) where no quantitation was performed,  the occurrence of a chemical was not Included in calculating the mean
     (2) where only one concentration was reported  for  an unspecified number of determinations and/or samples, that concentration was included
         In the calculation as if only  one  determination had been performed
     (3) where several concentrations were  reported,  each was  Included individually in the calculation of the  mean
     (4) where an average value and the  number of determinations were given, but not  individual values,  the average value was  included (n)  times
         in the calculation of the mean
lumber of determinations calculated by  adding:
     (1) the number of Individual determinations performed (case C,3 and C,4 above)
     (2) 1 (one) for average values where number of determinations was unavailable.

 n.d.  » not detected
 n.q.  =* not quantitated

-------
        Table  7-20.   SUMMARY OF ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED ORGANICS
                      IN AMBIENT AIR IN HOUSTON, TX AND VICINITY
Concentration Range
Chemical (ng/m^)
carbon tetrachloride
chloroform
m-dichlorobenzene
tetrachloroethylene
1 ,1 ,1-trichloroethane
1 , 2-dichloroethane
chlorobenzene
trichloroethylene
o-dichlorobenzene
hexachloro-1 , 3-butadiene
trichlorobenzene isomers
dichloropropane isotner
dichloropropene isomers
bis (2-chloroisopropyl) ether
chloroprene
vinylidine chloride
dibromoe thane
dichlorobutane isomers
dichlorobutene isomers \
pentachlorobutadiene isomers
1, 1,2-trichloroethane
1,1,2 ,2-tetrachloroethane
1 , 2-dibromopropane
1,2, 3-trichloropropane
tetrachlorobutadiene isomer
trichloropropene isomers
1 , 1-d ichloroethane
1,1,1, 2-tetrachloroethane
pen tachloroe thane
vinyl chloride
T-11,538
T-53,846
T
T-2,019
T-27,700
T-66,300
T-125
T-5,071
T
T-2,066
T
T-2,586
T-1,293
T-333
266-4,000
T-531
T-158
52-700
. T-262
T-100
3,334-6,700
19-33
T
298
T
T
555
21
3,984
T
Frequency
Detected
30
29
12
26
25
22
9
20
6
7
4
5
4
3
2
3
2
2
2
2
3
2
1
1
1
1
1
1
1
1
Number of
Determinations
30
30
13
30
30
30
13
30
13
17
13
17
17
17
17
25
17
17
17
17
30
30
17
17
17
17
30
30
30
30
Percent
Occurrence
100
97
92
87
83
73
69
67
46
41
31
29
24
18
12
12
12
12 .
12
12
10
7
6
6
6
6
3
3
3
3
See reference  7.60,  7.61,  7.62,

-------
Drinking Water
     Table 7-21 summarizes the halogenated organics found in drinking water
in the Houston, TX area.  Many of the compounds occur at the ppb level.
Human Breath
     Table 7-22 provides information on the concentration of halogenated
hydrocarbons which was detected in 10 expired air samples from male volunteers
at the Brooke Air Force Base in Texas.
                                    80

-------
Table 7-21.  LEVELS OF HALOGENATED ORGANICS FOUND  IN WATER IN  THE  HOUSTON AREA
Chemical
Trichlorobutane
Trlchloropentene
Trlchloroethylene
Trichloroetliane
Dichlorobenzene
Bis (chloroisopropyl) ether
Trichlorohexane
Carbon Tet rachlorlde
Chlorof ortu
Tet rachloroethylene
Dichlorobutane
Olchlorolteptane
Chloroprene dlmer
Pen cachlo roan iaole
flls(chloroethyl)ether
Dlchloroethane
llexachlorubutadleite
Trlchloropropaue
Bromof urra
Clilorophenol
Number of
Cone. Range (Mg/£) Cone. Mean (|ig/O Decarmlnacions
185 1
92 I
197-0.9 54 18
119-0.1 24 14
21 1
19 1
16 2
13 15
82-<.l 8.9 20
8 4
8 2
4 1
2 2
2 2
1.4 1
1.3 3 .
2.0-n.d. --.1 1
1 1
a. d.
n.d.
References
7.38
7.38
7.38,7.48
7.49
7.48.7.49
7.38
7.59
7.38
7.38,7.48,
7.49
7.38,7.48
7.49,7.50
7.38
7.38
7.38
7.38
7.38
7.59
7.38
7.46
7.38
7.50
7.59
Production Data (million Ib./yr.)


Diamond Shamrock, Deer Park (90),
Dou Chem. , Freeport (150)
1,1 , 1-Trichloroethane: Dow Chem.,
Freeport (450), 1, 1 ,2-Trlchloro-
ethane: Dow Chera. , Freeport (n.a.)





Diamond Shamrock, Deer Park (160);
Dow Chem., Freeport (120)





1 , 2-Dlchloroet hane : Diamond Shaiu-
rock. Deer Park (550); Dow Chem.,
Freeport (1600) and Oyster Creek
(1100); Ethyl Corp., Pasadena (260)
Shell Chem. Co., Deer Park (1200)




                                  (continued)

-------
                                                                               .Table  7-21  (cont'd.)
                                              Cone.  Ranj;e     Cone.  Mean
                  Chemical                       (Mg/£)           (MB/lt)       Determinations     Reference     Production Data (million  Ib./yr.)
                  Dlchlorodlbromomethane          n.d.                                           7,50

                  Dlchlorotoluene                 n.d.                                           7.50

                  1,2-Dlchloropropane                                                                        Dow Cliem. ,  Freeport (25).

                  Vinyl Chloride                                                                             Dow Chem.,  Freeport (200)  and  Oyster  Creek  (700);
                                                                                                             Ethyl Corp., Pasadena (150);  Shell  Chem.  Co.,
                                                                                                             Deer Park (840).

                  Methylene Chloride                                                                         Dow Chem.,  Freeport (200).

                  l-Chloro-2,  3-Epoxypropane                                                                 Dow Chem.,  Freeport (250);  Shell Chem.  Co.,
                  (Eplchlorohydrln)                                                                           Deer Park (110).
                   Houston area includes sites in Morgan  Point, Deer Park, Lynch, Bayou> Freeport, North Shaver, Turning, Pelican,
                   Texas Bayou, Houston, Red  Fish, Port Nechea.

OO                 Cone, range omitted  where none was cited, or where individual pieces of data were not given, or when a range cited
"^                 in one reference  was exceeded  by a value reported in another reference in which no range was given.

                  CConc. mean is the arithmetic average of concentration data, with the following limitations imposed by the nature
                   of the reporting:

                     (1) where no quantification  was performed the occurrence of a chemical wag in no way included in calculating
                         the  mean!
                     (2) where only  one concentration was reported for an unspecified number of determinations <(n) and/or samples,
                         that concentration was included  In the calculation as if only one determination had been performed;
                     (3) where several  concentrations vere reported, each was included individually in the calculation of the mean;
                     (4) where an average value and the number of determinations <(n) performed were given, but individual values
                         were not given,  the  average value was included n times in the calculation of the mean.

                   Numbe-  of  determinations was calculated by adding, where given:

                     (1) the  number of  Individual determinations performed (case C3 and C4 above).
                     (2) 1 (one)  for  average values given where no number of determinations was given, (case C2 ;ibovc) .

-------
                 Table 7-22.   HALOGENATED HYDROCARBONS  DETECTED  IN  TEN  EXPIRED  AIR  SAMPLES  FROM
                                       MALE VOLUNTEERS  AT BROOKS AFB, TX  3
00
to
Compound
1,1, 1-trlf luorotrlchloroethane
roethylene chloride
dime thy Idlfluorosllane
1,1,1-trlchloroe thane
dichlorobenzene
chloroform
vinylidine chloride
trime thy If luoroa liana
trlchloroethylene
tetrachloroe thane
1,2-dlchloroethane
vinyl chloride
fluorochloroethylene
dlchlorof luoronve thane
trlchlorof luorome thane
dlchlorodlf luoroethylene
chlorobenzene
1 , 1-dichloroethane
Mean
(ug/hr)
71.4
44.0
24. 1
16.9
3.2
1.3
1.3
0.52
0.43
0.20
0.08
0.073
0.054
0.020
0.008
0.0068
0.002
T
Range of
Positives
(ug/hr)
2.6-580
0.12-340
1.2-140
0.034-140
0.001- 26
T-ll
13
5.2
T-3.9
.022-2.0
T-0.80
T-.73
0.54
0.062-0.14
0.007-0.041
0.002-0.029
0.002
T
Number of
Positives
6
5
10
4
7
5
1
1
4
2
2
3
1
2
4
4
1
1
       Eight Volunteers; one was sampled three times.
       Arithmetic mean with non-detected samples counted as zero.
      Source;  J. P. Conklo, A. J. Cutnp, and B. E. Welch, "Trace Composition of Human Respiratory Gases,"
               Arch. Environ. Health, _30, 290-295 (1975).

-------
REFERENCES
 7.1  Serat, et al.,  "Pesticides in People", Pest. Mon. J.,  11(10), 1-4
      (1977).
 7.2  Sims, et al., "Organochlorine Residues in Fish and Fishery Products
      from the Northwest Atlantic", Bull. Environ. Contam. Toxicol., 18,
      697-705 (1977).
 7.3  Yang, et al., "Organochlorine Pesticide Residues in Sugarbeet Pulps
      and Molasses from 16 States,  1971", Pest. Mon. J., 10, 41-43 (1976).
 7.4  Johnson, R. D.  and D. D.  Manske, "Pesticide Residues in Total Diet
      Samples (IX)",  Pest. Mon. J., 9_, 157-169 (1976).
 7.5  Firestone, D.,  "Determination of Polychlorodibenzo-£-Dioxins and
      Polychlorodibenzofurans in Commercial Gelatins by Gas-Liquid Chroma-
      tography", J  Agr. Food Chem.,  25,  1274-1280 (1977).
 7.6  Rowe, £t al., "Dieldrin and Endrin Concentrations in a Louisiana
      Estuary", Pest. Mon. J.,  4, 177-183 (1971).
 7.7  Dymnet, P. G.,  et al.,  "Relationship Between Levels of ChJorinated
      Hydrocarbon Insecticides  in Human Milk and Serum", Bull. Environ.
      Contam. Toxicol., 6, 449-452 (1971).
 7.8  Watson, M., ejt al.,  "Serum Organochlorine Pesticide Levels in People
      in Southern Idaho",  Pest. Mon.  J.,  4, 47-50 (1970).
 7.9  Dale, W. E., et al., "Determination of Chlorinated Insecticides in
      Human Blood", Ind. Med. Surg.,  36,  275-280 (1967).
7.10  Hammer, D. I.,  £t al.,  "Polychlorinated Biphenyl Residues in the
      Plasma and Hair of Refuse Workers", Environ. Health Perspect. , 1,
      83 (1972).
7.11  Curley, A. and  R. Kimbrough,  "Chlorinated Hydrocarbon  Insecticides
      in Plasma and Milk of Pregnant  and Lactating Women", Arch. Environ.
      Health, 18,  156-165  (1969).
7.12  Serat, W.  F., et al., "DDT and  DDE in the Blood and Diet of Eskimo
      Children from Hooper Bay; Alaska",  Pest. Mon.  J., 11,  1-4 (1977).
7.13  Warnick, S.  L., "Organochlorine Pesticide Levels in Humrn Serum and
      Adipose Tissue, Utah -  Fiscal Year 1967-71," Pest. Mon.  J., 6, 9-13
      (1972).
                                     84

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7.14  Morgan, D.  P.  and  C.  C.  Roan,  "Chlorinated Hydrocarbon Residue in
     Human Tissues", Arch.  Environ.  Health,  20, 452-457 (1970).
7.15  Keil, J. E.,  et al.,  "DDT and  DDE Residues in Blood from Children,
     South Carolina - 1970",  Pest.  Mon.  J.,  6,  1-3 (1972).
7.16  Davies, J.  E. , e_t  al. ,  "Problems  of Prevalence of Pesticide Residues
     in Humans", Pest.  Mon.  J.,  2,  80-85 (1968).
7.17  Strassman,  S.  C. and  F.  W.  Kutz,  "Insecticide Residues in Human Milk
     from Arkansas  and  Mississippi,  1973-74",  Pest. Mon. J.,  10, 130-133
     (1977).
7.18  Savage, E.  P., et  al.,  "Organochlorine  Pesticide Residues and Poly-
     chlorinated Biphenyls  in Human Milk",  Pest.  Mon. J. ,  7_,  1-3 (1973).
7.19  Kroger, M., "Insecticide Residues in Human Milk", J.  Pediat.,  80,
     401-405  (1972).
7.20  Hagyard, S. G., et al.,  "DDT and  DDE Content of Human Milk in
     Arizona",  Bull. Environ.  Contam.  Toxicol., 9. 1969-172 (1973).
7.21  Quinby, G.  E., et  al.,  "DDT in Human Milk",  Nature, 207,  726-728
     (1965).
7.22  Laug, E. P.,  et al.,  "Occurrence  of DDT in Human Fat  and  Milk",  Arch.
     Indust. Hyg.,  3, 245-246 (1951).
7.23  Wilson, D.  J., et  al.,  "DDT Concentrations in Human Milk", Am.  J.
     Dis. Child, 125, 814-814 (1973).
7.24- Woodard, B. T., et al.,  "DDT Levels in  Milk of Rural  Indigent Blacks".
     EPA-600/1-76-032 (1976).
7.25  West, I.,  "Pesticides  and Contaminants",  Arch. Environ.  Health,
     9, 626-633  (1964).
7.26  Savage, E.  P., et  al.,  "A Search  for Polychlorinated  Biphenyls  in
     Human Milk  in Rural Colorado",  Bull.  Environ. Contam.  Toxicol.,
     9, 222-226  (1973).
7.27  Harps, W.  J.,  Jr.,  "Storage of Insecticides  in the Fat of People of
     New Orleans",  Life Sci.,  4, 1611-1675  (1965).
7.28  Hoffmann,  W.  S. , e_t al. ,  "Relationship  of Pesticide Concentrations
     in Fat to  Pathological  Changes  in Tissues",  Arch. Environ. Health,
     15, 758-765 (1967).
                                     85

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7.29  Casarett, L. J.,  et al.,  "Organochlorine Pesticide Residues in
      Human Tissue in Hawaii",  Arch. Environ.  Health, 17_, 306-311 (1968).
7.30  Hoffman, W. J. , et al. , "Relation of Pesticide Concentrations in
      Fat to Physiological Changes in Tissue", Arch. Environ. Health,
      15, 758-765 (1967).
7.31  Matthews, H. B.,  et al.,  "Hair and Its Associated Lipids as an Excre-
      tory Pathway for Chlorinated Hydrocarbon", Xenobiotica, 6, 425-429
      (1976).
7.32  Edmundson, W.  F.,  et al. , "Dieldrin Storage Levels in Necropsy Adipose
      Tissue from a South Florida Population", Pest. Mon. J. , 2, 86-89 (1968).
7.33  Kutz, F. W., et al., "Mirex Residues in Human Adipose Tissue", Environ.
      Entomol., 3, 882-5 (1974).
7.34  Kutz, F. W., et al., "Trans-Nonachlor Residues in Human Adipose Tissues",
      Bull. Environ. Contam. Toxicol., 16, 9-14 (1976).
7.35  Biros, F. J.,  et al.,  "Polychlorinated Biphenyls in Human Adipose Tissue",
      Bull. Environ. Contam. Toxicol., 5, 317-323 (1970).
7.36  Yobs, A. R., "Levels of Polychlorinated Biphenyls  in Adipose Tissue
      of the General Population of the Nation", Environ. Health Perspect.,
      1, 79-81 (1972).
7.37  Price, H. A. and R. L. Welch, "Occurrence of Polychlorinated Biphenyls
      in Humans", Environ. Health Perspect., 1, 73-78 (1972).
7.38  Ewing, B. B. ,  e_t al. ,  "Monitoring to Detect Previously Unrecognized
      Pollutants in Surface Waters", Contract No. 68-01-3234, EPA-560/7-
      77-001, July 1977.
7.39  Water Supply Monitoring and Surveillance Program,  U. S. EPA, un-
      published data.
7.40  Finlay, D. J., et  al., "Review of PCB Levels in the Environment", U. S.
      EPA,  EPA-560/7-76-001, January 1976.
7.41  Haile, C. L.,  et  al.,  "Chlorinated Hydrocarbons in the Lake Ontario
      Ecosystem", Contract No.  R-800608, EPA-660/3-75-022, June 1975.
7.42  McCarthy, E. M.,  "National  Survey of Pesticides in Drinking Water",
      Contract No. 68-01-2849,  June 1976.
                                     86

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7.43  Burke, T. A. and R. K. Tucker,  "A Preliminary Report, on the Findings
     of the State Groundwater Monitoring  Project",  N.  J.  Dept.  Environ-
     mental Protection, March 1978.
7.44  Symond, J. M., et al., "National  Organics  Reconnaissance Survey for
     Halogenated Organics", J.  Amer. Water Works  Ass.,  67_,  634-47 (1975).
7.45  Preliminary Assessment of  Suspected  Carcinogens  in Drinking Water,
     Report to Congress, U. S.  EPA,  O.R.D.,  December  1975.
7.46  Sampling and Analysis of Selected Toxic Substances:   Hexachloro-
     butadiene.
7.47  Private communication, N.  V.  Brodtmann, Jr.,  Jefferson Parish
     Department of Water, Jefferson, LA,  1978.
7.48  Battelle Columbus Laboratories, Environmental Monitoring Near Indus-
     trial Sites:  Methylchloroform, Contract No.  68-01-1983, EPA-560/5-
     77-025, August 1977.
7.49  Battelle Columbus Laboratories, Environmental Monitoring Near
     Industrial Sites:  Trichloroethylene,  Contract No.  68-01-1983,
     EPA-560/6-77-024, August 1977.
7.50  Bertsch, W. and E.,Anderson.  ."Trace  Analysis  of  Orgario Volatiles
     in Water by Gas Chromatography-Mass  Spectrometry with Glass Capillary
     Columns", J. Chromatogr.,  112,  701-18 (1975).
7.51  Preliminary Assessment of  Suspected  Carcinogens  in Drinking Water,
     Interim Report to Congress, U.  S.  EPA,  O.R.D., April 1975.
7.52  Analytical Report:  New Orleans Water Supply Study,  U.  S.  EPA,
     Region VI, EPA-906/9-75-003,  June 1975.
7.53  Laseter, John L., et al.,  "An Ecological Study of Hexachlorobutadiene
      (HCBD)", EPA Contract No.  68-01-2689,  April  1976.
7.54  Industrial Pollution of the Lower Mississippi River in Louisiana,
     U. S. EPA, Region VI, 1972.
7.55  Keith, L. H. , et. a_l. , "Identification of Organic Compounds in
     Drinking Water from Thirteen  U. S. Cities",  in Identification and
     Analysis of Organic Pollutants  in Water, L.  H. Keith,  ed.,  pp.  329-
     373  (1976).
                                     87

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7.56  Going, J. E. and J. L. Spigarelli, "Environmental Monitoring Near
      Industrial Sites:  Vinylidene Chloride", Contract No. 68-01-4115,
      EPA-560/6-77-026, October 1977.
7.57  Schafer, M. L. ,  et al.,  "Pesticides in Drinking Water; Waters from
      the Mississippi  and Missouri Rivers",  Environ.  Sci. Technol., 3_(12) ,
      1261-9 (1969).
7.58  Kraybill, H. F., "Distribution of Chemical Carcinogens in Aquacic
      Environments", Tumor Res.,  20, 3-34 (1976).
7.59  Private Communication, J. Smith,  O.T.S., EPA,  Washington, DC., 1978.
7.60  Pellizzari, E. D.,  "Improvement  of Methodologies for the Collection
      and Analysis of  Carcinogenic Vapors",  EPA Contract No. 68-02-2764
      in press.
7.61  Pellizzari, E. D.,  "Analysis of  Organic,..Air .Pollutants by Gas Chroma-
      tography and Mass Spectroscopy",  EPA Contract  No.  68-02-2262, in press.
7.62  Pellizzari, E. D.,  "Measurement  of Carcinogenic Vapors in Ambient
      Atmospheres", EPA-600/7-78-062,  April  1978.
                                    88

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                                  SECTION 8
         MUTAGENIC/CARCINOGENIC ACTIVITY OF HALOGENATED COMPOUNDS

     A summary  of  mutagenicity and carcinogenicity data for halogenated organic
compounds to  be studied  is  listed in Table 8-1.   This summary is useful not only
for quickly assessing  the mutagenicity/carcinogenicity of the study compounds
but also  for  determining where there is insufficient data which NCI may be
able to supply.
     The  summary presented  in Table 8-1 must be  viewed with some caution.   The
inaccuracies  of the  tests and their interpretations are well-known.  The defi-
nition of a significant  positive result varies from test-to-test and among
investigators.   Some of  the results summarized in Table 8-1 were not evaluated
in the original citation--the data were presented with no interpretation—and
the evaluation  was made  by  RTI personnel.  The experimental quality (controls,
etc.) of  some of the citations is also subject to question.  In addition,
some of the older  references may have produced negative results due to poor
testing sensitivity.
                                     89

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Table 8-1.  SUMMARY OF MUTAGENICITY AND CARCINOGENICITY DATA ON HALOGENATED COMPOUNDS.



Class
Industrial
Chemicals































Chemical Name
dich lor ome thane
dibromome thane
chloroform
tribromome thane
carbon tetrachloride
dibromodichlor ome thane
vinyl chloride
vinylidine chloride
1 , 2-dichloroethane
1 , 2-d ibromoethane
t rich loroe thy lene
1,1 ,1-trichloroe thane
1,1, 2- t rich loroe thane
tetrachlo roe thy lene
1,1,2 ,2-tetrachloroethane
dichloropropane
2-chlorobutadiene
(chloroprene)
1 ,4-dichloro-2-butene
hexachloro-1 , 3-butadiene
chlorobenzer.e
bromoberzene
o-dichlorobenzene
m-dichlorobenzene
jD-dichlorobenzene
o-chloroaniline
m-chloroaniline
_p_-chloroaniline
benzyl chloride
PCB (Aroclor)


NCI
Test
Status
CBT, CBT

+


CBT


+
+
± CBT (4)
?, CBT

-f, ?, CBT
+





CBT

CBT

CBT








Carcino'
genicir


±
+
+

+
+

+
±

+ (?)
-



?

-




+ (?)



?
-


^
Terato-
genicit


-







-


-
















MUTAGENICITY

CO
Bacteri
+ ?
+
+
+
±

•f
+
+
+
+


+

-

+ ?
+
SFT

-
SFT
SFT




+
+


C^l
vt
01
0)
































en
-H
00
1
+
-
-





+






-




-

+
+
+
+
+
+



Domina
Letha
(Mice































•o
cu
t-l U
CO CO
O -H
HI
































4)
4-1
O
































References
2,4,13,21
2
3,4,21
4,13
12,13,21

12,13,21
12,18,19,21
2,21
12
1,6-8,21

13,26
4,10,21
4
1,2

12,21
21
4,21
3
12
3,21
3,21
13
3
3
3
12,21
13,20,21

-------
Table 8-1 (cont'd.)


Class
Insecticides








Herbicides
Metabolites


















Chemical Name
Dieldrin

DDE
DDT
Aldrin
Heptachlor
O>,£'-DDD
£,£f-DDD
Heptachlor epoxide
Atrazine
chloroacetaldehyde
chloroethanol
trichloroacetic acid
3-chloro-o-cresol
4-chloro-o-cresol
5-chloro-o-cresol
5-chloro-3-methyleatechol .
3,4-dichlorocatechol
3,5-dichlorocatechol
3 ,6-dichlorocatechol
3,4 ,5-t rich lorocatechol
2 ,3-dichlorophenol
2 ,4-dichlorophenol
2 ,5-dichlorophenol
2 ,6-dichlorophenol
3 ,4-dichlorophenol
3,5-dichlorophenol

NCI
Test
Status
± (tech.)
- (purif.)
±
-
+ (tech.)
+
NR






















Carcino-
genicit;
+

+
+
+
+
+ (?)
+
+
?












+






Terato-
genicit
+


-
+






















MUTAGENICITY
i-*
(0
1
Bacteri
±

-







+
-f
-
-
-
-
-
-
-
-
-
-
-
-
-
-
—

UJ
id
01









•f


















V-*
to
U,












-














"V
•H
3



























•H Id
n) i-l
fl 
-------
                                                     Table 8-1  (cont'd.)
1


Class

Metabolites
(cont'd.)







Chenical Name

2,3,5-trichlorophenol
2,3 ,6-trichlorophenol
2 ,4 ,5-trichlorophenol
2,4 ,6-trichlorophenol
2 , 3,4,6-tetrachlorophenol
chloroacetic acid


NCI
Test
Status









i ?•<
C tl
-H 0
U 'rt
f* C
ID «
O M





—


;>.
O -rt
U U
n -H
V- C
U 01
H 00






MUTAGENICITY


N
41
U

	
-
-
-
-
*"•


4-1
V)
"•








-H
00
^







-»
S
"H







c
q
HI rH









|3
33 tj







c •-* '-^
a i: "
(j « X
a







•o
U) (4
O -H
tl
*







(|
tl









References

16
16
16
16
16
12,17
VO
to
+    Reported positive.
     Reported negative.
1    "Bacteria" includes:  Salmonella typhimurium, Escherichia coli, Bacillus subtilis, Klebsciella pneumoniac.
2    Saccharomyces cerevisiae.
3    Neurospora crassa, Aspergillus nidulans.
4    Drosphila raelanogaster.
NCI  Data based on Technical Reports and "Chemicals on Standard Protocol", NCI Carcinogenesis Testing
     Program, February 1, 1979.
NR   No Report, insufficient data.
CBT  Currently being tested.
SFT  Scheduled lor Test.

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REFERENCES  — Table  8-1
 1.   "Carcinogenesis  Bioassay of Trichloroethylene",  NCI Carcinogenesis
     Technical Report Series  No.  2,  Feb.  1976 (NCI-CG-TR-2).
 2.   M.  Bignam,  G. Cardamone,  P.  Comba,  V.  A. Ortali, G. Morpurgo, and
     A.  Carere,  Mutat. Res.,  46,  243-4 (1977).
 3.   I.  Prasad and D.  Pramer,  Genetics,  60,  212-3 (1968).
 4.   J.  C.  Theiss, G.  D.  Stoner,  M.  B. Shimkin,  and E.  K. Weisberger,
     Cancer Res., 37,  2717-2720  (1977).
 5.   S.  K.  Majumdar,  L.  G.  Maharam,  and G.  A. Viglianti, S. Hered., 6J3,
     184-5  (1977).
 6.   G.  F.  Smith, "Trichloroethylene:   A Review", Brit.  J.  Ind. Med.  23,
     249-262 (1966).
 7.   "Documentation  of the  Threshold Limit  Values for Substances in Work-
     room Air,"  Amer.  Conf.  of Governmental Industrial  Hygienists.  Third
     ed.  1971.
 8.   B.  B.  Fuller, "Air  Pollution Assessment of  Trichloroethylene," Feb.
     1976 (EPA-7/MTR-7142).
 9.   R.  Johns, "Air  Pollution. Assessment-of Tetrachloroethylene",  EPA-MTR-
     7143,  February  1976.
10.   B.  B.  Fuller, "Air  Pollution Assessment of  Tetrachloroethylene", EPA-
     MTR-7143, February  1976.
11.   J.  R.  Sanborn,  B. M. Francis, and R.  L. Metcalf, "The Degradation of
     Selected Pesticides in Soil:  A Review of the Published Literature,"
     EPA-600/9-77-022 (August 1977).
12.   J.  McCann,  E. Choi,  E.  Yamasaki,  and B. N.  Ames, Proc. Nat'l. Acad.
     Sci.,  USA,  72,  5135-5139 (1975).
13.   "Drinking Water and Health", National  Academy of Sciences, Washington,
     DC,  1977.
14.   L.  Fishbein, "Potential Industrial Carcinogens and Mutagens", EPA-
     560/5-77-005, May 1977.'
15.   J.  McCann,  V. Simmon,  D.  Streitwieser;  and  B. N. Ames, Proc.  Nat'l.
     Acad.  Sci.,  USA,  72, 3190-3193 (1975).
16.   L.  Rasanan,  M.  L. Hattula,  and A. U.  Arstila, Bull. Environ.  Contain.
     Toxicol. , 18, 565-71  (1977).
                                     93

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17.  "Criteria for a Recommended Standard .  .  .  Occupational Exposure to
     Ethylene Bichloride (1,2-dichloroethane)",  (NIOSH) 76-139, March 1976.
18.  J. Hushon and M.  Kornreich, "Air Pollution  Assessment of Vinylidine
     Chloride," EPA-MTR-7230 (PB 256 738), May 1976.
19.  R. D.  Huffman and P.  Desai-Greenaway, "Health and Environmental Impacts:
     Task 1,  Vinylidine Chloride" EPA-560/6-76-023 (October 1976),
20.  Chemical and Engineering News,  Apr.  24,  1978, p.  15.
21.  Environmental Mutagen Information Center  Data Bank,  Oak Ridge  National
     Labs,  Oak Ridge,  Tenn.
                                    94

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                                  SECTION 9
              BIOLOGICAL CHEMISTRY OF HALOGENATED HYDROCARBONS

     The  biological  chemistry of the halogenated hydrocarbons is central to
this  research  project.   In order to make any correlation among the environ-
mental  levels,  body-burden,  and disease incidence, the uptake, metabolism,
and excretion  of  halogenated hydrocarbons must be considered.  To this end,
the literature on uptake,  metabolism, and excretion has been reviewed and is
summarized in  this report.
     In addition,  the potential use of indirect indications of cancer was
investigated.  A number  of biological indicators were considered, including
plasma  alkaline phosphatase, serum glutamic-oxaloacetic transaminase (SCOT),
y-glutamyl transpeptidase,  ornithine carbamyl transferase, serum aryl hydro-
carbon  hydroxylase,  and alphafetoprotein.  Unfortunately,  only the Carcino-
embryonic Assay presented any realistic hope of providing data relevant to
this  program.   Other assays  were insensitive, too complex for the available
level of  effort,  or  did not  have a large data base with which to compare the
results of this study.
     The  summary  of  the halogenated hydrocarbon metabolism literature and a
discussion of  CEA, including background and pretest results, are presented
below.  The deficiencies of  the available scientific data and methodology
are acknowledged:   lack of data on uptake from environmental levels, lack of
metabolism data for  some compounds, lack of excretion kinetics for many
compounds, and lack  of  more  definitive biochemical assays to augment chemical
analyses.   However,  it  is felt that the available data and techniques will
be invaluable  to  this study.

METABOLISM OF  HALOGENATED HYDROCARBONS
     The  biological  chemistry of the study compounds is important for several
reasons:   if compounds  are  readily metabolized, the metabolites may be the
                                     95

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analytes of interest for biological fluids.  In addition, the mutagenicity/
carcinogenicity of the metabolites must be known. • In order to assess  the
body-burden, the residence time in the body must be known.  The half-life of
the halogenated organics under study varies from a few hours (e.g., methylene
chloride) to several years (e.g.,  pesticides).   The route of excretion is
important to determine which biological samples are most important  (breath,
blood, urine, or tissue).
     In an effort to resolve these issues, a summary of the known biological
chemistry of the halogenated organics under study has been prepared and is
presented in Appendix B.  The major portion of this summary, Table B-l, was
taken from "Metabolism Summaries  of Selected Halogenated Organic Compounds
in Man and Environmental Media, A Literature Survey" by R. Huffman, C.
Latanich, T. Collins and .J. Caldwell which was prepared by Tracer Jitco for
Dr. Joseph Breen, Survey and Analysis Division, Office of Program Interpreta-
tion and Information, Office of Toxic Substances, EPA, under Contract No.
68-02-4116, Task 19.  The data presented in Table B-l were specially format-
ted by Tracer Jitco personnel for this study.   These summaries are the
result of an intensive effort to  comprehensively review the literature for
these compounds.
     The metabolism of the pesticides to be studied is summarized in Table
B-2.  Data on the kinetics of these metabolism/elimination reactions were
found only for dieldrin in pigeons and atrazine in pigs.  It may be assumed
that for DDT, DDE,  and heptachlor, the half-life of the pesticide or its
major metabolite is very long (several years)  in humans.

POTENTIAL UTILITY OF RADIOIMMUNOASSAY—CARCINOEMBRYONIC ANTIGEN
     In the search for diagnostic tools for the early detection of cancer,
many biochemical markers have been examined.  Few biochemical markers are
altered until extensive tumor growth has occurred.  The unique exception to
this is the carcinoembryonic antigen (CEA).  It is a small protein present
in the developing embryo and some cancers.  Plasma levels of CEA have been
used to monitor the clinical progress of some tumors.  Its use as a diagnostic
tool has been impaired by high numbers of false positive and false negative
results.  In addition, there is conflicting opinion on the threshold value

                                     96

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for a positive  finding.   In  spite  of  these drawbacks, the determination of
CEA is valuable  since  elevated  levels  of CEA have been the only predictive
biochemical marker  for cancer.   Elevated serum levels have been found in
patients with no clinical evidence of  carcinoma who later developed carcinomas
A rise in  CEA frequently  precedes  tumor recurrence after surgery, chemotherapy
or radiation treatment.
    For the purposes  of  this  study the question of whether a particular
individual does  or  does not  have cancer is not as important as the incidence
of cancer  in different populations.   A considerable body of data exists on
CEA blood  levels in various  populations and can be used to evaluate the
populations in  this study.
Historical Data  Base for  the Correlation of CEA and Disease State and
Smoking
    Normal healthy subjects with  no  smoking history were examined for their
CEA titres using a  radioimmunoassay (RIA)  procedure according to Hansen (1).
These  results are summarized in Table  9-1.  Approximately equal numbers of
male and female  subjects  were  represented  among the 1425 individuals studied.
Another group of 2107  subjects  with no known disease was evaluated for CEA
levels.  These  results are summarized  in Table 9-2.  Some malignant and non-
malignant  disease states  influence the levels of CEA.  For example, the
levels in  2033  patients with clinically diagnosed malignant disease are given
in Table 9-3.   The  levels for  non-malignant conditions are given in Table 9-4.
    All of the  data presented  in  Tables 9-1 through 9-4 were derived using
the Hansen method (1).  Other  RIA  methods  have been used and are listed with
their  unique characteristics in Table  9-5.  Due to the commercial availa-
bility of  the Hansen RIA  procedure as  a kit and the large population data
base,  this is the method  of  choice.
    Urinary CEA levels have been  determined and a correlation with certain
diseases exists.  Table 9-6  shows  some of  these results.  It may be useful
to determine CEA in urine even  though  the  results are somewhat ambiguous due
to the elevation of CEA by urinary infections.
                                      97

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                              Table 9-1.  CEA TITRES IN HEALTHY NON-SMOKING  SUBJECTS
00
Age
<20
21-30
31-40
41-50
51-60
61-70
<70
All ages
No. of
Subjects
224
506
248
202
111
99
35
1425

0.0-2.5
94.6
92.1
88.7
80.2
77.5
85.9
85.7
88.5
Percentage of Subjects
ng/ml 2.6-50.0 ng/ml
4.5
7.3
10.5
19.3
17.1
10.1
11.4
10.2
Having CEA Levels
5.1-10.0 ng/ml
0.9
0.6
0.8
0.5
5.4
3.0
2.9
1.2
In Each Range
10.1-20.0 ng/ml
0.0
0.0
0.0
0.0
0.0
1.0
0.0
0.1

>20 ng/ml
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
         ^
          Reference 1.

-------
                                                                                                  *
            Table  9-2.   CEA TITRES  IN HEALTHY SUBJECTS  -  SMOKERS,  NON-SMOKERS  AND  PREGNANT  FEMALES
Subject
Type
Non-smokers
Presently smoking
Former smokers
Pregnant females

No.
892
620
235
360
Percentage
0.0 - 2.5 ng/ml
97.0
81.0
93.2
96.1
of Subjects Having
2.6 - 5.0 ng/ml
2.8
15.0
5.1
3.0
CEA Levels
5.1 - 10.0
0.2
3.1
0.8
0.8
In Each Range
ng/ml >10.0 ng/ml
0.0
0.9
0.8
0.0
*
 Reference 1

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                     Table 9-3.   CEA TITRES IN PATIENTS  WITH  CLINICALLY SUSPECTED MALIGNANT DISEASE
o
o
Disease (site)
Carcinomas
colorectura
lung
pancreas
stomach
breast
other
Non-carcinoma malignant disease
malignant lytnphoma
sarcoma
acute and chronic leukemia
other=
Non-malignant disease
normal
benign tumor
hyperplasia
other@
No. of
Subjects

544
181
55
79
125
343

72
38
40
78

62
143
45
231
Percentage of
0.0 - 2.5 ng/ml 2.6

28
24
9
39
53
51

65
69
63
50

81
82
79
86
Patients Having
- 5.0 ng/ml 5.

23
25
31
32
20
28

24
26
25
41

16
12
17
11
CEA
1 -

14
25
25
10
13
12

11
5
7
8

3
6
4
3
Levels In Each Range
10.0 ng/ral >10 ng/ml

35
26
35
19
14
9

0
0
5
1

0
0
0
0
     Reference  1
     Prostate,  head,  neck,  ovary,  cervix.
     Multiple myeloma,  astrocyatoma,  mesothelioma  and  neuroblastoma.
     "Crolin's disease,  fibrocystic disease,  colitis, pancreatitis.

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                 Table 9-4.  CEA TITRES IN 3340 PATIENTS WITH NON-MALIGNANT DISORDERS
o
Percentage of Patients Having CEA
Levels in Each Range (ng/ml)
Disorder
pulmonary emphysema
alcoholic cirrhosis
ulcerative colitis
regional ileitis
granulomatous colitis
gastric qlcer
duodenal ulcer
rectal polyps
diverticulitis
breast disease
(benign)
osteoarthritis
myasthenia gravis
bronchitis
obesity
hernia
diabetes
heart condition
hypertension
No. of
Patients
49
120
146
97
59
94
166
90
84
115

112
183
61
55
103
230
289
156
0.0 - 2.5
43
30
69
60
53
55
70
81
73
85

70
82
67
69
77
62
61
72
2.6 - 5.0
37
44
18
27
27
29
22
15
20
11

24
17
25
28
22
34
32
26
5.1 - 10.0.
16
24
8
11
15
15
6
3
5
4

5
1
7
3
1
3
5
2
10.0
4
2
5
2
5
1
2
1
2
0

1
0
1
0
0
1
2
0
                                               (continued)

-------
                                           Table  9-4  (cont'd.)
o
N>
Percentage of Patients Having CEA
Levels In Each Range (ng/ml)
Disorder
Crohn's disease
hemorrhoids
divertlculosls
pancreatitis
hypo thyroid ism
kidney transplant
anemia
cholelithiases
cholecystitis
alcohol addiction
pneumonia
tuberculosis
hepatitis
other d'isoru^rs
No. of
Patients
29
49
58
95
47
45
70
54
39
37
28
30
69
481
0.0 - 2.5
86
67
59
47
68
44
57
82
77
35
54
63
70
67
2.6 - 5.0
12
28
38
31
28
39
34
17
17
40
42
35
29
28
5.1 - 10.0
2
4
3
18
4
12
8
1
5
13
4
2
1
5
10,0
0
1
0
4
0
5
1
0
1
12
1
0
0
0
     Reference 1.

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Table 9-5.  COMPARISON OF RIA METHODS FOR CEA
Method
(References)
Hansen (1)
Thomson (2)
Egan (3)
McPherson (4)
Coller (5)
MacSween (6)
H-*
S Go (7)
Preliminary
Extraction
1.0 M HC10.
— 4
1.0 HC10.
4
none
none
none
none
none
Method of Separating
CEA from CEA - anti CEA
zirconylphosphate gel
50% (NH,)0SO.
42 4
second antibody
solid phase
radioimmunoelectrophoresis
second antibody
zirconylphosphate gel
Lapsed Time
for assay (Days)
2
5
2
5
0.083
2
2
Upper Limit
of "normal"
2.5 ng/ml
2.5 ng/ml
16 ng/ml
2.5 ng/ml
not quantitative
5.0 ng/ml
2.0 ng/ml
Population
assayed
>10,000
-vlOO
unknown
unknown
unknown
unknown
unknown

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       Table  9-6.  URINARY  CEA LEVELS  IN HEALTHY SUBJECTS AND SEVERAL DISORDERS
Health Status
Normal controls

Carcinoma of the bladder:

1) Treated with no evidence of
recurrence of tumor
2) with secondary infection

Non-urethelial malignant tumors

Benign disease

Urinary infection

Sex
M
F
M
F
M
F
M
F
M
F
M
F
M
F
No.
<35
42
30
16
2
32
9
2
0
16
5
6
3
0
0
of Subjects in Each
(ng/ml)
35-60
3
8
5
2
1
1
2
0
0
3
1
0
0
1
61-100
1
4
6
0
0
0
0
0
0
1
0
1
0
0
Range
>100
1
6
20
9
1
0
13
3
0
2
0
1
5
3
Positive
To
Total
5/47
6/48
31/47
9/13
2/37
0/10
5/17
3/3
0/16
2/11
1/7
1/5
5/5
3/4
n
 Reference 8,

 The threshold for positive CEA in urine was 35 ng/ml for men and 100 ng/ml for women.

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Carcinoembryonic Antigen  (CEA)  Analysis  on Residents of the Old Love
Canal Area of Niagara Falls,  NY --  A Pilot Study
    Blood samples  from the nine participants in the pilot study at "Old Love"
Canal, Niagara Falls, NY  were analyzed for carcinoembryonic antigen (CEA) by
the procedure specified for the CEA-Roche Kit (Roche Diagnostics, Nutley,
NJ).  Briefly, the  elements of this procedure are described below.
Collection of Samples
    The blood samples were collected in 10 ml Vacutainer tubes containing
EDTA and potassium  sorbate  (#4759 Vacutainer, Becton Dickinson and Company).
The samples were centrifuged  immediately for 30 min in a clinical centrifuge,
and the plasma was  withdrawn  and placed in labelled containers.  These
samples were refrigerated until they were returned to the laboratory where
they were frozen until analyzed.
Indirect Assay for  CEA
    Perchloric Acid Extraction—Duplicate aliquots of each plasma sample
(0.5 ml) were diluted with  2  ml of 0.85% Nad and mixed.  2.5 ml of perchloric
acid (1.2 M) was added to each tube and mixed.  The samples were then centri-
fuged  for 20 min at 1000  x  g  and the supernatants decanted into dialysis
bags.  The bags were labelled and securely fastened before dialysis against
water  (250 ml/bag)  with 4 changes of water and a minimum of 3 hr between
changes with thorough mixing  maintained throughout the dialysis.  A final
dialysis was performed against 0.01 M ammonium acetate (pH 6.5 + 0.2).  The
extracts were then  assayed  by the radioimmunoassay (RIA) procedure.
    RIA Procedure—Standards were prepared by adding 5 ml of the EDTA
buffer  (provided in the kit)  to each of 5 pairs of labelled tubes.  Aliquots
of the CEA standard were  added to each to provide duplicate standards with 0,
1.25,  3.125, 6.25 and 12.5  ng CEA per sample.  The contents of each dialysis
bag were placed in  labelled tubes and treated exactly like the standards
above.  CEA antiserum  (25 |Jl) was added to each tube (in small batches to
facilitate accurate timing) and mixed.  The tubes were incubated at 45°C for
                                       125
30 min and removed.  Twenty-five (Jl of    I-CEA was added, mixed, and incuba-
ted as above for 30 min.  2.5 ml Z-gel (Zirconyl phosphate gel provided in
the kit) was added, rapidly mixed,  and centrifuged at 1000 x g for 5 min.
                                     105

-------
The supernatants were decanted.  The Z-gel was further washed with 5 ml  of
0.1 M ammonium acetate by mixing, centrifuging and decanting the  supernatant.
The remaining Z-gel was counted in a gamma scintillation spectrometer.   A
calibration curve was constructed from the standards and used to  estimate
the sample concentrations.
Results and Discussion
     The results of the analysis of the 9 participants in the pilot study
are given in Table 9-7.  The CEA-Roche procedure indicates standard deviations
are roughly +0.5 ng/ml in the 0 to 5 ng/ml range.
     CEA levels are not considered elevated until they exceed 2.5 ng/ml by
this procedure.  Three individuals from "Old Love"  Canal fall into that
category.   In a normal healthy population of non-smokers the predicted
frequency of elevated CEA is 3 in 100 and 19 per 100 for smokers.  Of the 9
participants in this study,  5 were smokers.  By using a weighted average
incidence of elevated CEA levels for smokers -and non-smokers, th^ 3 elevated
CEA levels in this pilot study was of borderline significance (barely signi-
ficant at the 90% confidence level).   This is a very small population to
attempt to analyze statistically;  however, it does  demonstrate the approach.
                                     106

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   Table 9-7.   PLASMA CEA LEVELS IN THE "OLD LOVE" CANAL STUDY
Sample No.
1
2
3
4
5
6
8
9
10
Mean ng/ml
1.40
2.58+
1.98
1.18
3.02#
2.29
1.11
1.91
2.74#
A
Standard Error
ng/ml
0.46
—
0.21
0.21
0.69
0.27
0.66
0.30
0.50
The standard error was computed from (s     ,   ,   + s~    ..   )n
                                        standards     samples


Initial assay resulted in loss of one sample.   A separate assay was

made after the expiration date of the Kit.


Initial assay resulted in loss of one sample and insufficient plasma

remained for a repeat.
                               107

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REFERENCES
     Hansen, H.  J.,  J.  J.  Snyder,  E.  Miller,  J.  P-  Vandervoorde,  0. N.
     Miller, L.  R.  Hines,  and J.  J.  Bums.   Carcinoembryonic Antigen
     (CEA) Assay.   Human Pathology,  5:139-147,  1974.
     Thompson, D.  M.  P., J.  Krupey,  S.  0.  Freedman, and P.  Gold.   The
     Radioimmunoassay of Circulating Carcinoembryonic Antigen of the
     Human Digestive System.  Proc.  Nat"l.  Acad.  Sci., 64:161-167, 1969.
     Egan, M. L.,  J.  T. Lautenschleger,  J.  E.  Coligan, and  C.  W.  Todd.
     Radioimmune Assay of Carcinoembryonic Antigen.  Immunochem.,  9:289-
     299, 1977.
     McPherson,  T.  A.,  P.  R. Band,  M. Grace,  H.  A.  Hyde, and V. C.
     Patwardhan.  Carcinoembryonic  Antigen (CEA):   Comparison of the
     Farr and Solid-Phase Methods  for Detection of  CEA.   Int.  J.  Cancer,
     12:42-54, 1973.
     Coller, J.  A.,  R.  W.  Corichlow,  and L.  K.  Yin.  Radioimmunrelectro-
     phoretic Binding Assay  for the Detection of Carcinoembryonic  Anti-
     gen.  Cancer Res., 33:1684-1688, 1973.
     MacSween, J.  M., N. L.  Warner,  A.  D.  Bankhurst,  and I.  R.  MacKay.
     Carcinoembryonic Antigen in Whole  Serum.   Brit.  J.  Cancer, 26:356-
     360, 1972.
     Go,  V.  L. W.,  A. J. Schutt,  C.  G.  Moertel,  W.  H. J. Summerskill,
     and  H.  R. Butt.   Radioimmunoassay  of Carcinoembryonic  Antigen
     (CEA).   A Modified Method and  a Clinical Evaluation.   Gastroentero-
     logy, 62:7540,  1972.
     Hall, R. R.,  D.  J. R. Laurence,  A.  Munro Neville, and  D.  M.  Wallace.
     Carcinoembryonic Antigen and Urothelial  Carcinoma.   Brit.  J.  Urology,
     45:88-92, 1973.
                                      108

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                                 SECTION 10
             DEMOGRAPHIC AND  METEOROLOGICAL CHARACTERISTICS OF
                        SEVERAL  POTENTIAL STUDY SITES

     To  assist  in both,  the  site  selection and data interpretation, demo-
graphic  and meteorological  data  have been collected for the potential study
sites.   The data collected  include:   wind roses,  population density maps,
USGS  topographic maps,  other  local  maps, aerial photographs, and water
sources.   In  addition,  RTI  has all  of the US Census data,  in both hard copy
and computer  tapes,  which may  be accessed if necessary.
HISTORIC METEOROLOGICAL DATA  (WIND  ROSES)
     Wind data  for the  study  areas  were obtained from the  National Oceano-
graphic  and Atmospheric Administration (NOAA),  Asheville,  NC and converted
to wind  roses.  The  wind roses,  shown in Appendix C,  will  be invaluable for
planning sampling strategies  and for estimating population exposures.
MAPS
     Topographic maps  (7-1/2 minute) were obtained for all of the potential
study sites.  These  maps are useful for obtaining plant coordinates for
population mapping and  aerial  photographs,  roughly determining the population
near  the potential sites, determining the topography, and  selecting sampling
locations.
     Maps from  other sources  (commercial, state,  local government, chamber
of commerce,  banks,  etc.) have been collected as available.  These maps are
generally more  up-to-date and  often give pertinent information such as plant
names and street names  which are not always given on the USGS maps.
POPULATION DENSITY MAPPING  FOR STUDY AREAS
     Arrangements were  made with the Bureau of  the Census  through the
Project  Officer to obtain population density maps for the  plant sites of
interest to this study.  The population density maps  for the study areas are
shown in Appendix D.  The population density maps provide  information
                                     109

-------
pertinent not only to selection of sampling locations but also for the
epidemiological studies later in this program.
     The exact locations for the plants at the study sites were determined
by discussion with EPA personnel, state and local officials, and RTI personnel
who have been to the areas.  The plants were then located on USGS 7-1/2"
quadrangle maps and the longitude and latitude calculated.  Table 6-1 lists
the plants of interest, their locations, compounds produced, and the popula-
tion radius selected for mapping.  Some plant coordinates are missing, where
the plant could not be pinpointed on a map.  These locations will be filled
in following the first trip to an area.
AERIAL PHOTOGRAPHY
     Aerial (or satellite) photographs of selected plant sites were obtained
by the. Project Officer, J. Breen, from EPA-EMSL, Remote Sensing Division-Las
Vegas.  The photographs are extremely helpful, in conjunction with the maps,
for determining industrial vs.  residential areas.  In addition, such factors
as tree cover are obtainable.  For the maps thus far obtained, overlays have
been constructed showing the plants, points of interest, and, where applicable,
previous sampling locations.
     As an example, parts of two aerial photographs for Baton Rouge, LA have
been reproduced here,.  The photographs are shown in Figure 10-1 and 10-3.
It should be noted that the photograph received from the EPA was in color
(infrared).  The overlays for the areas shown in Figure 10-1 and 10-3 are
reproduced in Figures 10-2 and 10-4, respectively.  Not only are the plants
of interest to this study (Allied North, Allied South and Ethyl) shown, tut
also several other nearby industries.
     Additional aerial photographs are being prepared and will be treated in
a similar manner when received.
WATER SOURCES
     The water companies serving the sampling sites in New Jersey are
listed in Table 10-1.  Similar data will be obtained for the other areas as
the study progresses.
     The Niagara Falls water treatment plant is located immediately to the
East of the Hooker chemical complex.  The water intakes are about AGO m out

                                       110

-------
                                 Reproduced from
                                 best available  copy.
Figure 10-1.
Aerial photograph  (black and white copy of color print)  of
Allied North  and surrounding area, Baton Rouge, LA.   Scale
of original is  1:12,000.   Size of original is  46 x  46 cm.
                                   Ill

-------
               Cement
                 Plant
                 Kaiser
              Aluminum
                                  Exxon
                                 Refinery
Figure  10-2.  Reproduction of transparent overlay for Figure 10-1
             showing rough outlines of plant  sites.
                             112

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..;
Figure 10-3.
                      Infrared aerial photograph  (black and white copy of  color print) of Allied

                      North, Allied South, Ethyl,  and  surrounding area, Baton Rouge,  LA.  Scale

                      of  original  is 1:24,000.  Size of original is  50 x 60  cm; area  shown  is

                      is  32.5 x  50 cm.
                                                                                                      .
                                                                                                    5.S
                                                                                                    0°
                                                                                                    o 3
                                                                                                    t>

-------
Figure 10-4.
Reproduction of transparent overlay for Figure 10-3 showing rough outlines of
plant sites and other major features.

-------
Table 10-1.  WATER COMPANIES SERVING THE SAMPLING SITES IN NEW JERSEY
Municipality
Edison
Metuchen
Fords
Hopelawn
Water Company
Middlesex Water Co.
1 Woodbridge Center
Phone No. Contact
634-1500 Mr. Bastian
Mr. Mullen
Perth Amboy



South Amboy Jet.

Sayreville

Milltown

New Brunswick
Perth Amboy Water Co.
590 Smith St.
Perth Amboy

South Amboy Water Co.

Sayreville Water Co.

Milltown Water Co.

New Brunswick Water Co.
76 Bayard
826-0290
Mr. Langenohl
727-0171
Mr.  Piatek
745-5061    Don Carey
Bound Brook
Rutherford
E. Rutherford
Carlstadt
Woodridge
Moonachie
Secaucus
Elizabethtown Water 'Co. 354-4444 Mr. Caden
Hackensack Water Co. 863-0500 Don Hoven





Source:  Harry Smith, USEPA, Region II, New York
                               115

-------
from the treatment plant in the Niagara River.  This treatment plant  serves
the entire city.
RECONNAISSANCE OF THE NEW JERSEY STUDY AREA
     On July 13,  1978, Dr. M. D. Erickson of RTI drove through some of the
potential study sites in northern New Jersey.  Upon inspection, many  potential
sites could be eliminated for one reason or another.
     Tenneco.--Tenneco,  Ashland, and Hatco/Grace are located near the
Raritan River on bottomland.  Ashland manufactures alkyl cresols; Hatco/-
Grace manufactures plasticizers (phthalates and adipates); the town of Fords
represents a moderate study population and is generally considered downwind
from Tenneco although an elevated freeway (New Jersey 440) may interfere
with the air flow to the population area.  Nevertheless, this site may be
acceptable for purposes of this program.
     Tremley Point (DuPont, GAF, American Cyanamid).—Tremley Point is a
massive, sprawling industrial park.  Because many large, non-halogenated-
hydrocarbon-producing industries are located in this area (for example,
Exxon Bayway Refinery), because the population in Linden is somewhat  removed
(>3 kilometers) and population densities to the north and east lie in New
York (Staten Island) outside of the study area, and because GAF is currently
not operating (according to Dr. Menczel of Region II), this site appears to
be somewhat less than ideal as a suitable study site for this program.
     Prentiss Drug and Chemical and Troy Chemical.—These companies are
located near Wilson Avenue in Newark.  The area is an old, decaying indus-
trial park.  The nearby population is primarily located upwind (to the
west), although a sparse population to the north may be downwind during  some
of the time according to our meteorological data.  The site is further
complicated by other industries in the nearby area and heavy traffic  on  the
skyway and turnpikes near Doremus Avenue.  This does not appear to be a
suitable site for this program.
     White Chemical Company.--This company is located just east of the
residential neighborhoods of Bayonne at the beginning of a sprawling  indus-
trial area on Constable Hook.  The prevailing winds of this area  result  in
the Hudson River being downwind; the population to  the south  (about  1 kilometer)
                                       116

-------
is on Staten Island, NT which  may  be  considered outside the study area.  A
large amount of non-halogenated  industry is in the vicinity.  Thus the site
may be unsuitable for study.
    UOP.—UOP is located  along  a  four-lane artery (New Jersey 17) in East
Rutherford.  To the east, are the Meadowlands and Sports Complex.  To the
west beginning within three blocks is a dense housing area.  Thus the predomi-
nant downwind locations are unpopulated.   In addition, Region II personnel
have advised RTI that the  Rutherford  area is highly sensitized because of
the recent discovery of a  high incidence of childhood leukemia and Hodgkin's
disease.  This site has been under intensive study by the State, EPA, CDC
and others.
    Givaudan and Cosan.—In Clifton, NJ these two companies are about three
blocks apart and are in a  nearly ideal setting.  The population surrounds
the companies on all four  sides, both close and at a distance.  A minimum of
non-halogenated hydrocarbon industry  is present.  Minwax Plant #2, Passaic
Adhesive Chemical Company, and Rubber and Latex Company are all very small
nearby plants.  Cosan Chemical Company is a very small operation.  Givaudan
is, however, a very large  complex  of  buildings, both manufacturing•and
office, with an estimated  500-1000 people working at the time the site visit
was made.  The volume of HHC's produced and used is probably very low and
requires further investigation to  justify the selection of this site.
    Standard Chlorine Chemical  Company.--This company is located in the
Meadowlands at least 2 kilometers  from any significant population.  Despite
the fact that they produce large quantities of chlorinated benzenes (75, 75
and 18 million pounds per  year capacities for mono-, di-, and 1,2,4-trichloro-
benzene, respectively, according to 1977 Directory of Chemical Producers -
USA, Chemical Information  Services, SRI International, Menlo Park, CA,
94025) the population is rather  distant.   The concentrations of HHC's probably
decrease to very low levels before reaching the communities and thus human
exposure would be extremely small. However, further consideration needs to
be given to this site.
                                      117

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                                 SECTION 11
    SITES AND HALOGENATED HYDROCARBONS SELECTED FOR A COMPARATIVE ANALYSIS
                       BETWEEN MAN AND THE ENVIRONMENT

     This section utilizes the information in the previous Sections 5-10 in
selecting the sites and halogenated hydrocarbons for monitoring in the
environment to make a comparative analysis between man and the environment.
In keeping with the acquisition of information according to the schematic
shown in Figure 4-1, this section attempts to focus on the study design pro-
posed for the program based on the uncovered information.  Discussed here
are the events which lead to the halogenated hydrocarbons to be monitored
in the selected geographical areas in the respective environmental media in
an attempt to demonstrate their dosage to man with the subsequent monitoring
of the human sample to establish a human body-burden.
SUMMARY OF MOST PREVALENT HALOGENATED HYDROCARBONS
Vapor-Phase
     The vapor-phase halogenated hydrocarbons which occurred at the higher
concentrations in air and water were ranked and are listed in Tables 11-1 -
11-4.  The compounds were divided into two groups, those which are considered
to be ubiquitous, i.e. occurring at all of the geographical areas and dif-
ferent primarily only in concentration and those which are considered to be
areas specific.  A comparison of the halogenated hydrocarbons listed in
Tables 11-1 - 11-4 reveals a particularly interesting trend.  For the most
part, those which are considered major compounds and ubiquitous in air are
also commonly found in water.
     Of the many compounds which were identified and measured and reported  in
Section 7, the most prevalent ones were selected for representation in these
tables.   Attention was given primarily to the mean concentration at which
these compounds occurred and their mutagenic, carcinogenic or toxicity data.

                                      118

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Table 11-1.  PREVALENT HALOGENATED COMPOUNDS  IN  AMBIENT AIR AND WATER
                   OF NIAGARA FALLS AND BUFFALO,  NY
Medium
Air






Water







Ubiquitous
chloroform
tetrachloroethylene
1,1,1-trichloroethane
trichloroethylene
carbon tetrachloride


bromodichlorome thane
chloroform
tetrachloroethylene
chlorodibromome thane
m-dichloro benzene
1,1, 1-trichloroe thane
carbon tetrachloride

Mean Cone.
89,000 ng/m3
6,800
3,600
540
1,700


8.3 pg/a
3.1
2.0
2.0
0.4
0.3

Occurrence
Area Specific
chlorobenzotrifluoride isomers
chloro toluene isomers
trichlorobenzene isomers
trichlorotoluene isomers
1 , 3-hexachlorobutadiene
dichlorotoluene isomers
dichlorobenzotrif luoride
tetrachlorobenzene isomers
trichlorobenzene isomers
1 , 3-hexachlorobutadiene
bromoform




Mean Cone.
11,400 ng/m3
6,800
2,300
320
250
310
193
1.5 yg/£
0.5
0.07
0.05




-------
             Table 11-2.  PREVALENT HALOGENATED COMPOUNDS IN AMBIENT AIR AND WATER
                      OF RAHWAY/WOODBRIDGE, BOUNDBROOK AND PASSAIC,  NJ
Medium
Ubiquitous
                                                     Occurrence
Mean Cone.
Area Specific
                                                                                        Mean Cone.
Air       tetrachloroethylene
          trichloroethylene
          1,1,1-trichloroethane
          1,2-dichloroethane
          chloroform
          carbon tetrachloride
          o^,tn,f>-dichlorobenzenes
          chlorobenzene

Water     dichlorobenzene
          trichloroethane
          chloroform
          trichloroethylene
          dichloroethane
          bromodichloroethane
          bromodichloromethane
          tetrachloroethylene
          dlbromochloromethane
                                    210,000 ng/nT
                                    125,000   ,
                                     62,000
                                     96,000
                                     47,000
                                     29,000
                                     11,000
                                      2,700
                                        209
                                         42
                                         14
                                          7
                                          5
                                          5
                                          3.7
                                          3.6
                                          3.3
                                        1,1,2-trichloroethane
                                        vinyl chloride
                                        1,2-dichloroethylene
                                        1,1,2,2-tetrachloroethane
                                        chloronitrobenzene
                                        methyl trichlorophenoxy acetate
                                        methyl dichlorophenoxy acetate
                                        bromopropylbenzene
                                        bromobenzene
                                        tetrachloroethane
                                        dichloroethylene
                                                    9,000 ng/nT
                                                    1,200
                                                    1,000
                                                      750
                                  10
                                                         7
                                                       5
                                                       3.5
                                                       3
                                                       3
                                                       2.5
                                                       1.8

-------
        Table 11-3.  PREVALENT HALOGENATED COMPOUNDS OCCURRING IN AMBIENT AIR AND WATER
                          OF BATON ROUGE,  GEISMAR AND PLAQUEMINE,  LA
Medium
                Ubiquitous
                                                      Occurrence
                               Mean
                    Area  Specific
                                  Mean
Air
Water
chloroform
1,2-dichloroethane
carbon tetrachloride
1,1,1-trichloroethane
trichloroethylene
tetrachloroethylene
1,1-dichloroethane

trichloroethylene
chloroform
trichloroethane
diehloroethane
carbon tetrachloride
dichlorobenzene
chlorodibromomethane
tetrachloroethylene
,500 ng/m"
,656
 811
 605
 142
 118
  86
  96
  20
  11
   7.7
   7.1
   4.2
   3.5
   1.9
1,1,2-trichloroethane
1,2-dichloroethylene
dichlorobutane
1,2-dichloropropane
vinylidene chloride
1,1,2,2-tetrachloroethane
bromobenzene
1,2-dichloroethylene
hexachloroe thane
                                                                                           632 ng/nf
                                                                                           472
                                                                                           409
                                                                                           306
                                                                                             78
                                                                                             70
                                                                                            13 yg/Jl
                                                                                             4
                                                                                             1.6

-------
Table 11-4.  PREVALENT HALOGENATED COMPOUNDS OCCURRING IN AMBIENT AIR AND WATER
                    OF HOUSTON, DEER PARK AND PASADENA,  TX
Occurrence
Med ium
Air








Water







Ubiquitous
1 , 2-dichloroethane
1,1, 1- trichloroethane
chloroform
carbon tetrachloride
trichloroethylene
o,m,£-dichlorobenzenes
tetrachloroethylene
1 , 1-dichloroethane
chlorobenzene
trichloroethylene
trichloroethane
dichlorobenzene
carbon tetrachloride
chloroform
tetrachloroethylene


Mean Cone.
3,162 ng/m
2,428
1,000
532
345
300 O100 ea.)
189
162
164
54 yg/fc
24
21
13
9
8
,

Area Specific
1 , 2-dichloroethylene
1,1, 2- trichloroethane
chloroprene
dichloropropane isomer
vinylidene chloride
pen tachloroe thane
hexachloro ethane


trichlofobutane
trichloropentane
bis- (chloroisopropyl) ether
trichlorohexane
dichlorobutane
dichloroheptane
chloroprene dimer
pentachloroanisole
Mean Cone.
697 ng/m3
584
251
243
188
156
121


185 yg/fc
92
19
16
8
4
2
2

-------
Pesticides
    Table 11-5 presents  the  ranking of the pesticides and PCB's by reported
concentrations in human fat and  milk.   These data represent a summary of the
information which was presented  in Section 7 which indicated that the pre-
dominant concentration of pesticides and PCB occurred in fat and milk.  For
the pesticides which were measured,  the predominant species were DDE, DDT,
mirex  and PCB's.  Although these data  were not exclusively obtained for the
areas  selected for study  in this program, they do represent a general trend
upon which a selection of the pesticides for monitoring in human tissue and
milk can be made for the  five geographical areas.
EXTRAPOLATED DOSAGE OF HALOGENATED HYDROCARBONS TO MAN
    The potential human  24 hr dosage  based upon the mean concentrations of
halogenated hydrocarbons  for  the four  geographical areas (Houston, Baton
Rouge,  NJ, and Niagara/Buffalo,  NY)  are presented in Tables 11-6 - 11-9.
The dosage was calculated using  a human air and water intake of 8,640 2/24
hrs and 1 2/24 hrs, respectively.   Based upon the average concentrations
which  were given in- the previous table (11-1 - 11-4), the potential dosage
from air + water was determined.  As in the previous tables, the compounds
were again grouped according  to  their  occurrence as ubiquitous or area speci-
fic.
    The general criterion which was used for selecting an arbitrary cut-off
point  was a potential dosage  of  ^1 pg/24 hrs of a substance.  An estimation
can be made as to whether it  is  possible to detect using the current analyti-
cal methodology, the halogenated hydrocarbons diluted in 8 2, of human blood
(average man 70 kg) for a dosage of 1  |Jg/24 hrs.  This calculation of course
does not account for the  half-life (metabolism and/or excretion) of a compound;
however it does provide an estimation of the maximum quantity of halogenated
hydrocarbon which might be present in the blood.  From this value, then it can
be determined whether it  is potentially possible to detect a compound by the
analytical techniques to  be employed.   An example of such calculation is as
follows:
                                          3                 3
                          [air cone, (pg/m ) x air intake (m /24 hr)] +
    Blood Level (jjg/£) = [water conc./Hg/2)x water intake Mg/A)	
                                            o J6

                                      123

-------
            Table 11-5.  RANKING OF PESTICIDES AND PCB's BY REPORTED CONCENTRATIONS
                                     IN HUMAN FAT AND MILK
Compound
DDE
DDT
Mlrex
PCB's
BHC
Dieldrin
Heptachlor epoxlde
ODD
t-Nonachlor
Oxychlordane
End r in

Wtd . Mean
Cone.
4,836
2,651
2,500
2,080
472
155
145
95
50

<30
Fat3
Number
of Samples
2,444
1,545
6
836
1,044
659
672
114
5

246
Milkb
Wtd. Mean
Cone.
99
94

<10
3.4
4.0
3.5
4
1
5


Number
of Samples
103
100

96
106
92
71
54
57
57

 All fa: and adipose tissue samples included, except milk fat, cone.  = ppb.

 Whole raijk only.
•~t
"All isomers summed.

 Mean value calculated from a weighted mean of values in Table 7-4.    Where either the mean or number
 of samples analyzed were unavailable, the data were excluded from calculation.

-------
             Table 11-6.  TOTAL POTENTIAL 24 HR DOSE OF HALOGENATED  COMPOUNDS  TO  HUMANS  FROM
                             AIR AND WATER IN NIAGARA FALLS AND BUFFALO, NY
fo
Oi
Ubiquitous
Compound
chloroform
tetrachloroethylene
1,1, 1-trlchloroethane
carbon tetrachloride
bromodichlorome thane
chlorodibromome thane


Media
A,W
A,W
A,W
A,W
W
W

Total:
ng/24 hr
772,060
60,752
31,404
14,690
8,300
2,000

889,200
Area Specific
Compound
chlorobenzotrif luoride isomers
chlorotoluene isomers
trichloroebenzene isomers
trichlorotoluene isomers
dichlorotoluene isomers
1, 3-hexachlorobutadiene
dichlorobenzotrif luoride

Media
A
A
A,W
A
A
A,W
A
Total:
ng/24 hr
98,496
58,752
20,372
2,765
2,678
2,230
1,667
187,360

-------
Table 11-7.  TOTAL POTENTIAL 24 HR DOSE OF IIALOGENATED COMPOUNDS TO HUMANS FROM
        AIR AND WATER IN RAHWAY/WOODBRIDGE, BOUNDBROOK, AND PASSAIC, NJ
Ubiquitous
Compound
tetrachloroethylene
trichloroethylene
1,1, 1-trlchloroe thane
1, 2-dichloroethane
chloroform
carbon tetrachlorlde
o,m,j>-dichlorobenzenes
chlorobenzene
bromodichloro ethane
bromodlchloromethane
dlbromochloromethane

Media
A.W
A,W
A,W
A,W
A,W
A
A
A
W
W
W
Total:
ng/24 hr
1,818,000
1,087,000
57 ,680
834,440
420,000
250,560
304,040
23,330
5,000
3,700
3,300
5,327,130
Area Specific
Compound
1,1,2-trichloroethane
vinyl chloride
chloronitrobenzene
1, 2-dichloroethylene
1,1,2, 2-tetrachloroethane
methyl trichlorophenoxy acetate
methyl dlchlorophenoxy acetate
bromopropylbenzene
bromobenzene



Media
A
A
W
A
A,W
W
W
W
W


Total:
ng/24 hr
77,760
10,368
10,700
10,440
8,980
5,000
3,500
3 , 000
3 , 000


132,748

-------
Table 11-8.  TOTAL POTENTIAL 24 HR DOSE OF HALOGENATED COMPOUNDS TO HUMANS FROM AIR AND WATER
                         IN BATON ROUGE, GEISMAR AND PLAQUEMINE, LA&
Ubiquitous
Compound
trlchloroethylene
chloroform
1, 2-dichloroethane
carbon tetrachlorlde
1,1, 1-trichloroe thane
methylene chloride
dichlorobenzene
chlorodibromome thane
tetrachloroethylene
1 , 1-dichloroethane

Media
A,W
A,W
A,W
A,W
A,W
A,W
W
W
A,W
A
Total:
ng/24 hr
97,230
67,520
22,007
14,110
16,227
10,255
4,200
3,500
2,920
8,440
224,402
Area Specific
Compound
bromobenzene
1,2-dichloroethylene
1,1,2-trichloroethane
dichlorobutane
hexachloroe thane
vinylidene chloride
1,1,2, 2-tetrachloroethane




Media ng/24 hr
W 13,000
A,W 8,078
A 5,460
A 3,534
W 1,600
A 673
A 604



Total: 32,949
Based upon human air and water intake of 8,640 £/24 hr and 1 £/24 hr,  respectively.

-------
 Table 11-9.  TOTAL POTENTIAL 24 HR DOSE OF HALOGENATED COMPOUNDS TO HUMANS  FROM AIR AND WATER
                           IN HOUSTON, DEER PARK, AND PASADENA,  TX3
Ubiquitous
Compound
trichloroethylene
1, 1, 1-trlchloroethane
1, 2-dichloroethane
dlchloro benzene
methylene chloride
carbon tetrachlorlde
tetrachloroethylene
chloroform
chlorobenzene
1,1-dlchlo roe thane






Media
A,W
A,W
A
A,W
A
A,W
A,W
W
A
A





Total:
ng/24 hr
54,290
45,000
27,320 .
23,596
22,378
17,596
9,633
7,640
1,417
1,400





210,270'
Area Specific
Compound
trichlorobutane
trichloropentane
bis-(chloroisopropyl)ether
trichlorohexane
dichlorobutane
1,2-dichloroethylene
1,1, 2-trichloroethane
dichloroheptane
chloroprene
dichloropropane isomer
chloroprene dimer
pentachloroanisole
vinylidene chloride
pentachloroe thane
hexach oroethane
-
Media
W
W
W
W
W
A
A
W
A
A
A,W
W
A
A
A
Total:
ng/24 hr
185,000
92,000
19,000
16,000
8,000
6,022
5,045
4,000
2,169
2,099
2,000
2,000
1,624
1,348
1,045
347,352
*Based  upon human air and water intake of 8,640 £/24 hr and 1 £/24 hr, respectively.

-------
     Blood Level  (Mg/2)  =  [2'9  HS/24 hr]  + [54 Hg/24 hr] =  _        _
                                         82                £       ml

     assuming  4 half-lives,  the concentration may be as low as 0.437 2£
                                                                     ml.

     Beginning with the  potential dosage  of halogenated compounds to humans
from air  and water in Niagara Falls and Buffalo, NY, the data listed in
Table 11-6 indicate substantial quantities of compounds can be ingested
during a  24 hr period.   Recalling that these calculations are based on
mean concentrations which  were  observed in these areas, then it is conceiv-
able for  chloroform, mg  quantities may be ingested by the human population.
Furthermore, the  total human body-burden  load of halogenated hydrocarbons
may reach well into the  mg/24 hr period.
     The  levels of ubiquitous halogenated hydrocarbons occurring in the
selected  sites for Northern  New Jersey appear to be considerably higher than
the other major geographical areas selected for study.  The potential dosage
of many of the ubiquitous  halogenated compounds may reach well into the
mg range/a 24  hr  period  when considering  their ingestion through air and
water.  The total human  body-burden of halogenated hydrocarbons is in the
mg range  on a  24  hr basis.
     The  remaining two geographical areas, Baton Rouge, LA and vicinity and
Houston,  TX and vicinity also contain substantial quantities of halogenated
hydrocarbons which may lead  to  a significant human body-burden.  A comparison
of each of the tables clearly delineates  those compounds which are area
specific  and represent the most prevalent and thus highest total potential
dosage to man.
HALOGENATED HYDROCARBONS SELECTED FOR STUDY
Vapor-Phase
     As indicated in the sections on potential sources and the measured
halogenated hydrocarbons in  the environment, there are many compounds to
consider  in this  program.  The  magnitude  of the number of compounds which
have been found in each  of the  geographical areas is well beyond the level
of effort which this program can devote to their study.  For this reason,
a set of  criteria were defined  which were used to guide the selection of
                                     129

-------
compounds for study in making a comparative analysis between man  and  the
environment.  These criteria are:  (1) their known presence in environmental
media directly related to man's intake and exposure for the five  geographical
areas under consideration.  Their known presence were to be examined  on
the basis of site-specific vs. ubiquitous pollutants, their relative  concen-
tration and their propensity to persist in the environment; (2) their known
or suspected carcinogenic/mutagenic activity, e.g. those which are procarcino-
gens vs. co-carcinogens.  This information was presented in Section 8 of this
report.  In combination with other pollutants, the question to be asked was
whether they act synergistically or antagonistically.  Information concerning
their metabolism and metabolite activity was also considered and  discussed
in Section 9; (3) their known production, usage or disposal in the areas of
study, jL.e. their potential air emission, liquid effluents traced to  drinking
aquifers, their agricultural usages such as pesticides which might be involved
in run-off during precipitation and eventually contaminate the drinking water
supplies or foods and their resistance to biodegradation.  This information
was discussed in Section 6; (4) their presence in human biological fluids and
tissue.  Information concerning their half-life in the body was important
as to whether their monitoring was even feasible and their persistence as, ......
either parent compounds or major metabolites.  Again much of this information
was discussed in Section 7 and 9.
     Using these criteria as a guideline, a series of halogenated hydrocarbons
have been selected which are suggestive for monitoring in air, water  and
human samples.
Vapor-Phase
     Table 11-10 presents the compounds which have been selected  for  monitoring
in air and water in Niagara and Buffalo, NY.  Correspondingly, these  compounds
are proposed to be monitored in human blood (Table 11-11) and Tor the more
volatile constituents also in breath.  A tentative selection has  been made for
the compounds which are to be monitored in urine.
     Table 11-12 presents the halogenated hydrocarbons to be monitored in air
and water in Rahway/Woodbridge, Bound Brook and Passaic, NJ.  Of  course all of
these compounds will be monitored in blood (Table 11-13) while the more
volatile constituents are to be examined in breath.
                                     130

-------
        Table 11-10.
HALOGENATED COMPOUNDS SELECTED FOR MONITORING IN AIR AND WATER IN
           NIAGARA FALLS AND BUFFALO,  NY
                                 Air
                                                        Water
Ubiquitous
Area Specific
      chloroform
      1,1,1-trichloroethane
      carbon tetrachloride
      trichloroethylene
      tetrachloroethylene
      chlorobenzotrifluoride isomers
      chlprotoluene isomers
      trichlorobenzene isomers
      trichlorotoluene isomers
      1,3-hexachlorobutadiene
      dichlorotoluene isomers
chloroform
1,1,1-trichloroethane
tetrachloroethylene
bromodichloromethane
chlorodibromomethane
carbon tetrachloride
m-dichlorobenzene

trichlorobenzene isomers
tetrachlorobenzene isomers
1,3-hexachlorobutadiene
bromoform

-------
      Table 11-11.
HALOGENATED COMPOUNDS SELECTED FOR MONITORING IN HUMAN SAMPLES FROM
            NIAGARA  FALLS AND'BUFFALO, NY
                         Blood
                                            Breath
                            Urine
Ubiquitous
Area Specific
  chloroform
  1,1,1-trichloroethane
  carbon tetrachloride
  trichloroethylene
  tetrachloroethylene

  chlorobenzotrifluoride isomers
  chlorotoluene isomers
  trichlorobenzene isomers
  trichlorotoluene isomers
  dichlorotoluene isomers
  tetrachlorobenzene isomers
  bromoform
  1,3-hexachlorobutadiene
chloroform
1,1,1-trichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
 To be selected.

-------
             Table 11-12.
HALOGENATED COMPOUNDS SELECTED FOR MONITORING IN AIR AND WATER IN
  RAHWAY/WOODBRIDGE, BOUNDBROOK AND PASSAIC, NJ
                                         Air
                                                     Water
     Ubiquitous
     Area Specific
LO
U)
        chloroform
        1,2-dichloroethane
        1,1,1-trichloroethane
        carbon tetrachloride
        trichloroethylene
        tetrachloroethylene '
        chlorobenzene
        o^ni,_p_-dichlorobenzenes

        vinyl chloride
        1,2-dichloroethylene
        1,1,2-trichloroethane
        1,1,2,2-tetrachloroethane
chloroform
1,2-dichloroethane
1,1,1-trichloroethane
trichloroethylene
tetrachloroethylene
bromodichloroethane
bromodichloromethane
dichlorobenzenes

chloronitrobenzene
methyl dichlorophenoxy acetate
bromopropylbenzene
bromobenzene

-------
       Table 11-13.
HALOGENATED COMPOUNDS SELECTED FOR MONITORING IN HUMAN SAMPLES FROM
   RAHWAY/WOODBRIDGE, BOUNDBROOK AND PASSAIC, NJ
                           Blood
                                             Breath
                             Urlnec
Ubiquitous
Area Specific
 chloroform
 1,2-dichloroethane
 1,1,1-trichloroethane
 carbon tetrachlorlde
 trichloroethylene
 tetrachloroethylene
 chlorobenzene
 o^m,2.-dichlorobenzenes
 bromodichloromethane

 vinyl chloride
 1,2-dichloroethylene
 1,1,2-trichloroethane
 1,1,2,2-tetrachloroethane
 chloronitrobenzene
 methyl dichlorophenoxy acetate
 bromopropylbenzene
 bromobenzene
chloroform
1,2-dichloroethane
1,1,1-trichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
bromodichloromethane

vinyl chloride
1,2-dichloroethylene
1,1,2-trichloroethane
 To be selected.

-------
    Tables 11-14 - 11-17 presents  the  halogenated substances selected for
monitoring in the two remaining  geographical areas.   The Greensboro, NC
area was selected essentially  as  a  control and thus  all of the ubiquitous
which are listed for the other four geographical areas will be monitored
in the air, water and blood  samples from Greensboro  as well as those com-
pounds which were designated as  area-specific.
Pesticide
    Table 11-18 presents the  pesticides and PCB's which have been selected
for correlative studies in biological tissue and soil samples for all of
the geographical areas.
                                      135

-------
Table 11-14.  HALOGENATED COMPOUNDS SELECTED FOR MONITORING IN AIR
      AND WATER IN BATON ROUGE, GEISMAR AND PLAQUEMINE, LA
                        Air
                                    Water
Ubiquitous
Area Specific
chloroform
1,2-dichloroethane
1,1,1-trichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene

1,1,2-trichloroethane
1,2-dichloroethylene
dichlorobutane
1,2-dichloropropane
1,1,2,2-tetrachloroethane
chloroform
1,2-dichloroethane
1,1,1-trichloroethane
carbon tetrachloride
chlorodibromomethane
dichlorobenzenes

1,2-dichloroethylene
bromobenzene
hexachloroethane
                              136

-------
        Table 11-15.  HALOGENATED COMPOUNDS SELECTED FOR MONITORING IN HUMAN SAMPLES
                         FROM BATON ROUGE, GEISMAR, AND PLAQUEMINE, LA
                           Blood
                                       Breath
                                  Urine
Ubiquitous
Area Specific
chloroform
1,2-dichloroethane
1,1,1-trichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
chlorodibromomethane
dichlorobenzenes

1,2-dichloroethylene
1,1,2-trichloroethane
dichlorobutane
1,2-dichloropropane
1,1,2,2-tetrachloroethane
bromobenzene
hexachloroethane
chloroform
1, 2-dichloroethane
1,1,1-trichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
chlorodibromomethane
1,2-dichloroethylene
1,1,2-trichloroethane
dichlorobutane
1,2-dichloropropane
1,1,2,2-tetrachloroethane
 To be selected.

-------
  Table 11-16.  HALOGENATED COMPOUNDS SELECTED FOR MONITORING IN
       AIR AND WATER IN HOUSTON, DEER PARK AND PASADENA, TX
                       Air
                                Water
Ubiquitous
Area Specific
chloroform
1,2-dichloroethane
1,1,1-trichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
chlorobenzene
o_,m,£-dichlorobenzenes

1,2-dichloroethylene
1,1,2-trichloroethane
chloroprene
chloroform
1,1,1-trichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
dichlorobutane
trichlorobutane
trichloropentane
bis-(chloroisopropyl)ether
trichlorohexane
                               138

-------
           Table 11-17.   HALOGENATED COMPOUNDS SELECTED FOR MONITORING IN HUMAN SAMPLES FROM
                                  HOUSTON, DEER PARK AND PASADENA, TX
                            Blood
                                    Breath
                               Urine
     Ubiquitous
     Site Specific
u>
VD
chloroform
1,2-dichloroethane
1,1,1-trichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
chlorobenzene
o^ni,£-dichlorobenzenes

1,2-dichloroethylene
1,1,2-trichloroethane
chloroprene
dichlorobutane
trichlorobutane
trichloropentane
bis-(chloroisopropyl)ether
trichlorohexane
chloroform
1,2-dichloroethane
1,1,1-trichloroe thane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
1,2-dichloroethylene
1,1,2-trichloroethane

dichlorobutane
     a
      To be selected.

-------
  Table 11-18.
PESTICIDES AND PCB's SELECTED FOR CORRELATIVE STUDIES
IN BIOLOGICAL TISSUE AND SOIL SAMPLES
     FOR ALL GEOGRAPHICAL AREAS
    Compound
                Structure
Molecular Weight
 y-BKC (Lindane)
                            H  Cl
                                            288
 g-BKC
                         Cl  H
                                            288
 cx-BHC
                            Cl  H
                                                            288
p,p'-DDE
                                                           318
p, p'-DDD
      Cl
                                 HCC1
                                              Cl
                                                           320
                             (continued)
                                 140

-------
                       Table  11-18  (cont'd.)
   Compound
Structure
Molecular Weight
p,p'-DDT
                                  354
Mirex
Heptachlor epoxide
                                       Cl
                            Cl
                                  Cl
                                           Cl
                                  Cl
                                       Cl
                                Cl    Cl
                             Cl
                                     Cl
                        Cl
                              Cl
                                   540
                                   386
PCB's
                          Cl
                  Cl
                                                          188 -  494
                                141

-------
APPENDIX A
   142

-------
Figure A-l.  Map of Buffalo and Niagara Falls, NY Area
             (x = sampling site near LaSalle Arterial).
                           143

-------
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Figure A- 2.   Map depicting sampling locations
             Niagara Falls, NY.
                         to 13 in
   144

-------
                         Table A-l.  SAMPLING PROTOCOL FOR VAPOR-PHASE  ORGANICS IN AIR FROM

                                 HOUSEHOLD BASEMENTS AND SCHOOL  ROOMS IN NIAGARA,  NY
-P-
Ul
Remarks
Sampling Time
Sampling Location (min)
1 198
2 135
3 235
4 207
5 562
6 212
7 186
8 192
9 151
10 200
11 154

Sampling Volume
(£)
268
95
258
300
597
140
134
283
219
263
226
(continued)
Date
Relative Humidity
2/9/78
52% RH
2/7/78
49% RH
2/7/78
66% RH
2/7/78
68% RH
2/8/78
50% RH
2/8/78
44% RH
2/9/78
49% RH
2/7/78
61% RH
2/9/78
37% RH
2/8/78
48% RH
2/8/78
31% RH

Time
Temp. (°C)
1051-1409
15°
1035-1250
22°
1055-1450
18°
1130-1457
16°
1013-1935
17°
0923-1255
19°
0910-1216
13°
1155-1507
18°
0950-1221
17°
0945-1305
22°
1038-1312
18°

Odora
6/6
10/9.5
9.5/10
6/6
8/8
6/7
1/1
1/1
1/1
1/2
1/1


-------
                                      Table A-1  (cont'd.)
Remarks
Q
Sampling Location
12A
12B
13A
13B
13C
Sampling Time
(mln)
480
520
490
490
536
Sampling Volume
W
43
47
44
66
72
Date
Relative Humidity
2/8/78
22% RH
2/8/78
25% RH
Time
Temp. (°C) Odors
0855-1655 ,
0845-1725 '
21°
0830-1460
0832-1642 1/1
23"
*s
 Each household basement was designated as a sampling location (Reference A-1).

 Using a scale of 1—10,  subjective evaluations were made for presence of chlorinated and general
 odors in basements.

-------
Table  A-2.   SAMPLING  PROTOCOL FOR COLLECTION OF SEMI-VOLATILE ORGANICS
       ON POLYURETHANE  FOAM FROM AIR IN HOUSEHOLD BASEMENTS  IN
                            NIAGARA,  NYa
Remarks
Sampling Location
1
2
3
4
5
6
7
8
9
10
11
Sampling Time
(min)
497
558
514
513
562
600
580
500
566
643
553
Sampling Volume
(4)
94,049
116,067
100,369
100,173
109,742
124,803
120,643
94,097
110,523
125,559
104,072
Data
2/9/78
2/7/78
2/7/78
2/7/78
2/8/78
2/8/78
2/9/78
2/7/78
2/9/78
2/8/78
2/8/78
Time
1051-1908
1025-1943
1056-1930
1130-2003
1013-1935
0923-1923
0912-1852
1155-2015
0934-1900
0945-2028'
1038-1951
 See Reference A-l.
                                  147

-------
         Table A-3.  ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED ORGANIC VAPORS IN AIR OF
                        HOUSEHOLD BASEMENTS AND SCHOOL ROOM IN NIAGARA, NY3
00
Sampling/Location
Chemical
dlchloroethylene
methylene chloride
chloroform
1,1,1-trlchloroethane
carbon tetrachloride
trlchloroethylene
tetrachloroethylene
pentachloroethane
pentachlorobutadlene
1 , 3-hexachlorobutadlene
chlorobenzene
dlchlorobenzene Isomer
dlchlorobenzene isomer
dlchlorobenzene isomer
trichlorobenzene Isomer
trlchlorobenzene isomer
trichlorobenzene isomer
LI
<263
1,534
1,670
3,656
200
1,224
6,346
<19
<22
<22
1,940
2,044
260
<30
642
58
<22
L2
<334
<714
834
506
496
2,920
10,652
<53
<63
114
4,232
4., 400
2,442
<63
10,084
1,010
<63
L3
<294
1,300
464
412
T(83)
270
3,342
<19
<23
<23
1,000
154
76
418
72
T(23)
<23
L4
<263
1,334
684
400
5,038
5,344
5,386
<17
<20
26
3,674
2,940
2,106
3,654
56
1,306
1,066
L5
T(79)
11,556
13,484
3,890
562
1,374
51,992
<10
T(10)
100
2,778
8,914
6,024
2,294
26
3,424
580
L6
T(334)
9,428
8,584
1,000
704
15,880
37,442
<36
<43
414
<107
100,476
51,600
34,686
27,228 '
2,370'
3,686
L12A
T(334)
4,000
2,668
<334
<95
T(116)
<163
<116
<140
<140
<348
<186
<186
<186
<140
<140
<140
Bc
<10
3.6
22
<5
<2
<5
<7
<5
<6
<6
<15
<8
<8
<8
<6
<6
<6
                                               (continued)

-------
Table A-3 (cont'd.)
Samp ling/ Location
Chemical
tetrachlorobenzene isomer
tetrachlorobenzene isomer
tetrachlorobenzene isomer
pentachlorobenzene isomer
chlorotoluene isomer
chlorotoluene isomer
dichlorotoluene isomer
dichlorotoluene isomer
dichlorotoluene isomer
trichlorotoluene isomer
trichlorotoluene isomer
trichlorotoluene isomer
trichlorotoluene isomer
trichlorotoluene isomer
tetrachlorotoluene isomer
tetrachlorotoluene isomer
chlorobenzaldehyde isomer
dichlorobenzaldehyde isomer
bromo to luene isomer

LI
16
12
<22
<22
2,552
3,820
8,836
3,956
<19
634
3,336
<19
1,142
<19
148
58
<26
<26
25

L2
1,832
9,600
<63
494
14,990 1
<53
20,926
6,316
<53
206
3,790
1,810
842
<53
168
<26
180
<63
T(53)
(continued)
L3
<23
62
<23
T(23)
,754
*C 1 Q
<^ 1 Q
86
48
46
62
T(19)
T(19)
<19
<27
<27
<19
<23
<19

L4
280
360
<20
18
4,586
<17
5,240
5,320
314
134
1,786
<17
594
60
<15
16
746
<20
134

L5
214
406
<10
30
3,022
<8
7,428
2,318
<8
1,644
4,908
466
160
<8
56
<8
34
<10
66

L6 L12A
2,400 <140
17,142 <140
<43 <140
250 <140
226,514 <116
223,042 <116
158,628 <116
98,428 <116
109,872 <116
6,886 <116
42,286 <116
43,700 <116
25,986 <116
<36 <116
<18 <116
970 <116
4,058 <116
950 <140
4,372 <116

BC
<6
<6
<6
<6
<5
<5
<5
<5
<5
<5
<5
<5
<5
<5
<7
<7
<5
<6
<5


-------
                                   Table A-3  (cont'd.)
Samp ling /Location
Chemical
bromochlorotoluene isomer
chloronaphthalene isomer
1,2-dichloropropane
total halogenated organics
LI
T(19)
78
1,406
59,489
L2 L3
<53 <19
84 <31
<53 <19
172,713 13,760
L4
80
<27
<17
58,968
L5
28
<13
<8
127,778
L6 L12A
1,542 <116
3,414 <186
<36 <116
1,786,636 7,644
Bc
<5
<8
<5

3See Table A-l for sampling protocol (Reference A-l).
b
 Values are in ng/m , T = trace, ( ) or < indicates limit of detection.
 Values are ng/cartridge.

-------
Table A-4.  SEMI-VOLATILE ORGANIC CHEMICALS IDENTIFIED IN AIR FROM
  HOUSEHOLD BASEMENT (LI). NIAGARA, NY USING PUT TECHNIQUE3
Chroma tographic
Peak No.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
Elution Time
(min)
0.73
0.86
1.00
1.24
1.38
1.54
1.86
1.89
2.13
2.19
2.46
2.73
3.44
4.06
Compound
dichloro toluene
trichlorobenzene
unknown
trichloro toluene
trichloro toluene
tetrachlorobenzene
tetrachlorobenzene
chloronaphthalene
dichloroaniline (tent.)
tetrachloro toluene
tetrachloro toluene
tetrachloro toluene
unknown
pen tachloro toluene
See Reference A-l.
                              151

-------
Table A-5.   SEMI-VOLATILE ORGANIC CHEMICALS IDENTIFIED IN AIR FROM
     HOUSEHOLD BASEMENT (L3),  NIAGARA,  NY USING PUF TECHNIQUE3
Chroma tographic
Peak No.
1
2
Elution Time
(min)
1.69
3.06
Compound
tetrachlorobenzene
pentachlorobenzene
  See Reference A-l.
                                152

-------
Table A-6.   SEMI-VOLATILE ORGANIC CHEMICALS IDENTIFIED IN AIR FROM
             HOUSEHOLD BASEMENT (L5), NIAGARA. NY USING
                     PUF COLLECTION TECHNIQUE
Chromatographic
Peak No.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
Elution Time
(min)
0.54
0.79
0.89
1.06
1.23
1.36
1.53
1.83
2.00
2.69
3.16
5.66
5.93
6.39
Compound
dichlorobenzene
dichlorotoluene
trichlorobenzene
hexachlorobutadiene
unknown
trichloro toluene
tetrachlorobenzene
tetrachlorobenzene
unknown
tetrachloro toluene
pentachlorobenzene
hexachlorocyclohexane
pentachloropropane
unknown
  See reference A-l.
                                153

-------
 Table A-7.   SEMI-VOLATILE ORGANIC CHEMICALS IDENTIFIED IN AIR FROM
             HOUSEHOLD BASEMENT (L6),  NIAGARA,  NY USING
                      PUF COLLECTION  TECHNIQUE3
Chroma tographic
Peak No.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18 .
Elution Time
(min)
0.36
0.43
0.59
0.73
1.01
1.26
1.49
1.56
2.26
2.73
3.19
3.36
3.46
4.3.3
5.79
6.00
6.76
11.39
Compound
chlorotoluene
dichlorobenzene
dichlorotoluene
trichlorobenzene
trichlorotoluene
tetrachlorobenzene
tetrachlorobenzene
a-chloronaphthalene
tetrachloro toluene
pentachlorobenzene
dichloronaphthalene
trichlorophenol (tent.)
pent achloro toluene
pentachloro toluene
hexachlorobenzene
unknown
hexachloro toluene
pentachlcrobiphenyl
(tent )
"See  reference  A-l.
                               154

-------
Table A-8.   SEMI-VOLATILE ORGANIC CHEMICALS IDENTIFIED IN AIR FROM
            HOUSEHOLD BASEMENT (L4),  NIAGARA, NY USING
                     PUT COLLECTION TECHNIQUE3
Chromatographic
Peak No.
1
2
3
4
5
6
7
8
9
10
11
12
13
Elution Time
(min)
0.71
0.83
0.86
1.33
1.46
1.63
1.69
1.73
1.79
1.93
2.59
3.06
3.79
Compound
dichloro toluene
dichlorophenol
trichlorobenzene
trichloro toluene
tetrachlorobenzene
chloronaphthalene
t rich lor ophenol
tetrachlorobenzene
tetrachlorobenzene
trichloroaniline (tent.)
tetrachloro toluene
pentachlorobenzene
pentachlorotoluene
                                                 (tent.)
       14
5.46
hexachlorocyclohexane
   See reference A-l.
                                155

-------
Table A-9.   SEMI-VOLATILE ORGANIC CHEMICALS IDENTIFIED IN AIR FROM
           HOUSEHOLD BASEMENT (L2),  NIAGARA, NY USING
                     PUF COLLECTION TECHNIQUE3
Chromatographic
Peak No.
1
2
3
4
5
6
7
8
9
10
12
13
14
15
16
17
18
19
20
21
22
Elution Time
(min)
0.76
0.93
1.39
1.53
1.83
2.43
2.69
3.00
3.06
3.13
3.43
3.96
4.89
5.66
5.76
6.06
6.39
6.69
7.33
9.09
10.13
Compound
dichloro toluene
trichlorobenzene
trichloro toluene
tetrachlorobenzene
tetrachlorobenzene
unknown
tetrachloro toluene
tetrachlorotoluene
hexachlorocyclohexane
pentachlorooenzene
unknown
pentachlorotoluene
' "pentachlorotoluene
pentachlorotoluene
hexachlorocyclohexane
dichlorobiphenyl (tent.)
hexachlorobenzene
unknown
hexachloro toluene
chlorobenzof luorene
(tent.)
hep tachloro toluene
 'See reference A-l.
                                156

-------
                        NIAGARA RIVER

	 1— 1 	 — 	 1, 	
•« — EAST 	 1-
	 LA SALLE EXPRESSWAY 	 •• WEST | !
J

FRONTIER AVENUE
Vt
s

VI
ff)
ff>
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AVENUE

in
oi
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COLV1N BLVD.

VI
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0
3
Figure A-3.   Map of "Old Love" Canal area of Niagara Falls,
             sampling locations for body-burden study.
                                 157

-------
Ln
oo
             Table A-10.   AIR EXPOSURE MONITORING PROTOCOL FOR THE "OLD LOVE"  CANAL  AREA OF

                                            NIAGARA FALLS, NY
Period of Air
Monitoring
Location
1
2
3b,c
4
5
6
8
9b
iob
Date
7/6/78
7/6,7/78
7/6,7 778
7/6/78
7/6,7/78
7/6/78
7/6/78
7/6/78
7/6,7/78
Inside
1022-1747
1800-0807
2113-0835
0929-1511
1548-0858
0854-1720
1103-1737
1041-1630
1655-0926
Outside
1028-1747"
1759-0810"
2113-0838
0927-1515
1550-0857
0857-1720
1102-1737
1045-1637
1700-0927
Volume of Air
Collected
(M3)/Cartrldge
Inside
0.020
0.041
0.034
0.017
0.051
0.026
0.017
0.017
0.050
Outside
0.022
0.042
0.034
0.017
0.051
0.025
0.017
0.018
0.049
Tanunter
Date No. of Samples
7/6/78 2
Same household as 1
7/6/78 2
7/6/78 2
7/6/78 2
7/6/78 2
7/6/78 2
7/6/78 2
7/6/78 2
Other Participant
10066
10090
10074
Radishes from 10017
backyard garden
10041
10033
10025
10009
10058
 The sampler was set up in the next yard, a corner lot and upwind of the "canal".


 Households previously Included in the basement air monitoring.


"Location of MRI weather station.

-------
          Table A-ll.  METEOROLOGY FOR JULY  6  AND  7,  1978  IN  THE "OLD LOVE" CANAL AREA OF
                                         NIAGARA FALLS.  NY
Date Time
7/6/78 1000
1200
1400
1600
1800
2000
2200
2400
7/7/78 0200
0400
0600
0800
1000
Temp (C°)
25
28
29
29
29
27
23
22
20
20
19
23
27
Wind: speed/Direction
(KM/Hr)
3 / S
3 / S
3 / S
2 /SSW
; <2 /SSW
<2 /SSW
calm
calm
calm
calm
calm
calm
2 /S
Wind speed/Direction
(KM/Hr)
13
17
20
24
24
18
15
13
13
9
13
14
20
SW
sw
SSW
sw
sw
sw
sw
sw
SSW
SSW
SSW
SSW
SSW
 MRI  weather station, 6" above ground level.
^Niagara Falls, N.  Y. Weather Station.

-------
          Table A-12.   ESTIMATED  LEVELS OF VAPOR-PHASE HALOGENATED COMPOUNDS IN AIR INSIDE HOMES IN
                                 "OLD  LOVE"  CANAL AREA OF NIAGARA FALLS, NY3
Compound
chloroform
carbon tetrachloride
1 , l-d±chloroethane
1, 2-dichloroethane
1, 1 , 1-trlchloroethane
trichloroethylene
tetrachloroethylene
chlorobenzene

1 2 -. 3
15,342 3,169 11,088
352 868
- - -
127
577 1,073
T
422 ' 794
_ _ _
Sample No.
4 5
3,486 3,646
T 33
-
-
T 364
T
540
- i-

6
2,392
T
-
-
1,216
T
1,334
588

8 9
1,429 Tb
657 -C
-
-
600
T
1,142
286

10
950
340
-
100
430
T
480
60
dichlorobenzene isomer(s)
chlorotoluene isomer(s)
dlchlorotoluene Isomer(s)
chloronaphthalene isomer(s)
bromotoluene tsomer(s)
trlchlorobenzene Isomer(s)
chlorobenzotrlf .'uorlde isomer(s)
tetrachlorobenzene isomer(s)
pentachlorobenzene
1,3-hexachlorobutadlene
trichlorotoluene isomer(s)
tetrachlorotoluene isomer(s)
1,542

-------
                                           Table A-12 (cont'd.)
     Compound
                                                        Sample No.
9    10
1,2-dichloropropane
chlorobenzaldehyde
dichlorobenzaldehyde
bromochlorotoluene isomer
1,2-dibromoethane
a                  3
 Values are in- ng/m .
bTrace.
c
 Not detected.

-------
Table A-13.   ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED COMPOUNDS IN AMBIENT AIR
                OUTSIDE HOMES OF "OLD LOVE" CANAL, NIAGARA,  NY3
Compound
chloroform
carbon tetrachlorlde
1 , 1-dlchloroethane
1 , 2-dichlo roe thane
1,1, 1-trlchloroe thane
trlchloroethylene
tetrachloroetbylene
chlorobenzene
dlchlorobenzene (2 Igomers)
1, 2-dlchloropropane
chlorotoluene (2 leomere)
chlorobenzaldehyde leoraer
dlchlorotoluene (3 Isomers)
chloronaphthalene isorner
bromotoluene leoraer
dlchlorobenzaldehyde laotner
trlchlorobenzene (3 Isomere)
1 , 2-dlbroraoethane
trlchlorotoluene (5 laoroers)
tetrachlorotoluene Isomer
bromochlorotoluene leomer
chlorobenzodichlorofluorlde isomer
Sample No.
1 2 3 4 5689 10
15,846 105,461 70,308 30,231 1,385 51,692 1,050 19,692 55,923
2,000 3,692 2,923 1,615 2,231 1,000 1,000 Tb
_ _ c
-T -NQdT
2.111 5,444 2,222 1,778 4,222 1,444 2,667 1,667
285 - - 611 -
591 714 735 14,000 647 400 750 2,111 122
119- it TT
190 206 T 353 T 350 444
-----TT--
T T 1,235 647 T - 2,750 T T
---------
T - - 648 T T 500 T T
T--T--TTT
------- -T
-T--TT---
-T-TTT-TT
T--TTT--
TTTTTTTTT
-TT--T---
— — -_ T
1 ~ — —
-'_
                                   (continued)

-------
                                        Table A-13 (cont'd.)

Compound 1 2
chlorobenzotrlf luorlde (2 iaomera) -
1, 2-bis (Crif luoromethyl) benzene -
pentachlorobenzene -
1 , 3-hexachlorobutadiene
1, 2-dichloroethylene -
Sample Mo.
3 4 5 6 8 9 10
T T T 300 T T
T * T - - T
T T - T
a               3
 Values are ng/m .
 Trace.
c
 Not detected.
 Not quantltated.

-------
                  Table A-14.  SAMPLING PROTOCOL FOR SITE NO. 2, NIAGARA FALLS,  N.  Y.  - TRIP 1
ON
Period
PI
7/8-7/9/78
P2
7/10-7/11/78


P3
7/11/78


„
P4
7/12-7/13/78






Location
Sampling
Time
Sampling
Volume (i)
Meteorological Conditions
Type of Wind Dir./
Sample T (°C) % RH Speed (km/h) Other
No Samples Collected

L5
L6
L7
L8
L5
L8
Lll
L12
L13
L5
L6

L7

L8
L9
L10

1135
1213
1235
1305



(7/10)-1151
(7/10)-1204
(7/10)-1220
(7/10)-1150



(7/H)
(7/11)
(7/11)
(7/11)


0910-1510
1230

1515
1005
0915
0930
0900
0910
0910
0840


(7/12)-0920
(7/12)-0908

(7/12)-0852

(7/12)-0844

(7/12)-1310


(7/13)
(7/13)

(7/13)

(7/13)

(7/13)

60. 9a
95. 4a
71.63
70. 2a
2 x 120 mlc
120 ml
22.0a,b,f
3 coregd
1«
89. 5a
77. 6a
2 x 120 mlc
63. ia
2 x 120 raic
72. 7»
3 cores''
19.53,6

Air 11-23 84-76 SSW-NW/11-28 light rain 0925
Air
Air
Air
Tap water 11-23 76-55 NW-NNW/11-24
Tap water
Ait
Soil
Tap water
Air 11-26 75-42 SSW-WSW/calm-19
Air
Tap water
Air
Tap water
Air
Soil
Air
        Volume of air/cartridge.                          '

        Average of 2 calculations:  1) Sampling time x flow rate; 2) Counts x Volume/count.

       °lst 120 ml - First water from tap; 2nd 120 ml = after 2 min run.

        5 cm diameter x 6 cm core.
       p
        Finished water - water treatment plant.

        99th Street Elementary School.

             Street Elementary School.

-------
Ln
                                                           J.-L-3C
                                                           i »f=	
                 -VJ HvdEr/ARK/   g;     \\l=-lUl^
                 EW ^ fl  |  Jk%*&
                 ^AwV- i     •  !"•"* ?iy <• -
                 T$$&\	t~  i-^at^
                 «4«\r/:f7j 4:;;i &•"*.. M ^Jfe   .
                 :MMlMf.^  -.js
     SAI TWk'isKW/rais:

     ^%» -VR^|-4:
      - NI..
       *r-=r—r <-^r=^
        g o - « 8  ^7
        §i-  ^ S

        5 .'•  .8 3 .  -\
 r^ "§ •      i     •  n

'^rf^/'  ^4"
      --J     rn
      - -^ s—~~J
                      ""'''-c-r^^
r> j.'.'   '  •'14~^^.—


NIAGARA CO  	|>m.H£At>	
 1 lilt CO
                                                                                   O

                                                                                   Q-
                                                                                  (I ^

                                                                                   o

                                                                                  o 3
         Figure A-4.  Sampling locations and plant Identifications for Site No. 2, Niagara Falls, N. Y.

-------
                  Table A-15.  SAMPLING PROTOCOL FOR SITE NO.  3,  BUFFALO,  N.Y.  - TRIP  1
Period
PI
7/8-7/9/78
P2
7/10-7/11/78


P3
7/11/78



t— »
'ON
ON
P4
7/12-7/13/78


Location
No Samples

LI
L2
L3
L4
LI
L3
L4
L12
L13
L14

LI
L2
L3
L4
Sampling
Time
i Collected

0755
0820
0845
. 0905







0854
0904
0920
0931


(7/10)-0751
(7/10)-0745
(7/10)-0809
(7/10)-0822







(7/12)-0807
(7/12)-0735
(7/12)-0759
(7/12)-0752


(7/11)
(7/11)
(7/11)
(7/11)
;






(7/13)
(7/13)
(7/13)
(7/13)
Sampling
Volume (I)


87.28'b
74.7a.'j
60.3a»b
66.5a.b
2 x 120 mlc
2 x 120 mic
2 x 120 mlc
2 x 120 ralc
3 coresd '
ie

60. Oa
86. 7a ;
62. 4a
67.2a
HrteoroloRlcnl Conditions
Type of Wind Dlr./
Sample T (°C) 7. RH Speed (km/h) Other


Air 11-23 84-76 SSW-NW/11-28 light rain 0925
Air
Air
Air
Tap water 11-23 76-55 NW-NNW/11-24
Tnp water
Tap water
Tap water
Soil
Tap water

Air 11-26 75-42 SSW-WSW/calro-19
Air
Air
Air
 Volume of air/cartridge.
 Average of 2 calculations:   1) sampling time x flow rate;  2) counts x volume/count.
"1st 120 ml = First water  from tap;  2nd 120 ml = after 2 min. run.
 5 cm diameter x 60 cm core,
'Finished water - water treatment plant.

-------
                          Reproduced from
                          best  available copy.
Figure A-5•
Sampling  locations and plant identifications
at Site No.  3, Buffalo, N.Y.
                                 167

-------
ON
Co
       HE
                                                                                                1     k   '"fc
              Figure A-6.  GC/MS profile of vapor-phase  organics  in ambient air in Niagara Falls, Wf
                           (P4/L7).   See Table A-16.

-------
o\
          Figure A-7.  GC/MS profile of vapor-phase organics in ambient air in Niagara Falls  NY
                       (P4/L8).  See Table A-17.

-------
ill
T     S
T    I
     Figure A-8.  GC/MS profile of vapor-phase organics  in  ambient  air  in  Buffalo,  NY (PA/L2).
                  See Table A-18.

-------
Figure A-9.  GC/MS profile of vapor-phase organics in ambient air from Buffalo, NY (P4/L3).
             See Table A-19.

-------
--J
N>
          Figure A-10.  GC/MS profile  of  vapor-phase organlcs In ambient air from Buffalo, NY  (P4/L41)
                        See Table A-20.

-------
      Table A-16.   VAPOR-PHASE HALOGENATED ORGANICS IDENTIFIED IN
                        NIAGARA FALLS,  NY (P4/L7)a
ChroiMCo-
graphic
Peak No.
3
7
11
13
14
20
23
Elucion
Temp.
(•c?
64
71
75
31
31
95
101
Compound
c?2ci2
bromomethane (cenc.)
CCljF (Freon 11)
iMChylene chloride
CC12FCC1F2 (Freon 113)
chloroform
1 ,1, 1-trlchloroethane
Chromato—
graphic
Peak No.
24
29
39
42
56
66
83
Elution
Temp .
rc)
106
114
141
149
174
187
221
Compound
carbon cetrachloride
crichloroechylene
tetrachloroethylene
chlorobenzocrifluoride Isomer
chlorotoluene Isomer
dichlorobenzene isomer
chlorobenzocrlfluoride isoner
See Table A-14  for  sampling  protocol.
       Table A-17.  VAPOR-PHASE  HALOGENATED ORGANICS  IDENTIFIED  IN
                      NIAGARA FALLS,  NY  (P4/L8)a
Chroma co-
graphic
Peak No.
5
7
3
9
10
16
19
22
23
43
47
53
62
Elucion
Temp.
(*C)
73
75
77
80
81
94
101
106
113
141
148
160
173
Compound
CF2C12 (Freon 12) (tent.)
CC13F (Freon 11)
CH2C1F
methylane chloride
CC12FCC1F2 (Freon 113)
chloroform
1,1,1-trichloroethane
carbon cetrachloride
trichloroechylen*
tetrachloroethylene
chlorobenzocrif luoride isomer
chlorobeniotrifluoride isomer
chlorocoluene
Chromaco-
graphic
Pealc No.
67
73
78
91
93
96
100
101
108
109
112
114
118
Elation
Temp .
(°C)
181
186
191
209
214
220
227
228
240
240
240
240
240
Conpound
dichlorobensotrif luoride
m- and/or ^-dichlorobenzene
o-dichlorobenzene
dichlorocoluene isomer
dichlorocoluene Isomer
trichlorobenzene isomer
crichlorobenzene isomer
hexachlorobucadiene
crichlorotoluene isomer
crichlorocoluene isomer
cecrachlorobenzene isomer
cecrachlarobenzene isomer
pen cachloro benzene
 See Table A-14 for sampling protocol.
                                  173

-------
     Table A-18.   VAPOR-PHASE HALOGENATED ORGANICS IN AMBIENT AIR IN
                          BUFFALO,  NY (P4/L2)a
Chromato-
graphic
3
6
9
i:
14
21
-'-
Elution
Temp .
(°C)
64
70
75
81
82
95
10:
Compound
CF2C12
bromomethane (tent.)
CFC13 (Freon 11)
methvlene chloride
CC12FCC1F2 (Freon 113)
chloroform
1 , 1 , 1-trichloroethane
Chromato-
graphic
Peak No.
27
33
52
83
87
92

Elution
Temp .
CO
106
114
142
187
193
198

Compound
carbon tetrachloride
trichloroethylene
tetrachloroethylene
n- and /or £-dichlorobenzene
o-dichlorobenzene
trimethylphenyl chloride (cent.)

See Table A-15 for sampling protocol.
    Table A-19.   VAPOR-PHASE HALOGENATED ORGANICS IN AMBIENT AIR FROM
                          BUFFALO,  NY (P4/L3)3
Chr one co-
graphic
Peak \c.
3
8
10
11
1 ?
21
Elution
Temp .
(°C)
64
76
82
83
97
103
Compound
CT2C12
CC13F (Freon 11)
mechylene chloride
CC12FCC1F2 (Freon 113)
chloroform
1,1, l-trichloroethane
Chroma to-
graphic
Peak No.
22
29
45
81
85

Elution
Tentp .
(°C)
107
114
142
187
191

Compound
carbon tetrachloride
trichloroethylene
tetrachloroethylene
»- and /or £-dichlorobenzene
o-dichlorobenzene

See Table A-15 for sampling protocol.
                                 174

-------
     Table A-20.  VAPOR-PHASE HALOGENATED ORGANICS IN AMBIENT AIR FROM
                           BUFFALO,  NY (P4/L4)a
•
graphic
Peak No.
9
13
14
20
25
28
— — ^— —
Eluclon
Temp.
CO
75
30
81
94
101
105
Compound
CCl^F (Freon 11)
methylene chloride
CC12FCC1F2 (Freon 113)
chloroform
1,1, 1-crichloroechane
carbon cetrachlorlde
Chromaco-
graphic
Peak No.
34
52
83
89
94
118
Elucion
Temp.
CO
113
139
176
184
189
218
Compound
crlchloroechylene
cecrachloroechylene
C.-alkyl chlorobenzene isomcr
m- and/or p_-dichlorobenzene
o-di chlorobenzene
crlchlorobenzene Isoner
See  Table A-15 for sampling protocol.
                                  175

-------
                  Table  A-21.   ESTIMATED  LEVELS  OF  SITE-SPECIFIC VAPOR-PHASE HALOGENATED COMPOUNDS
                                       IN  AMBIENT  AIR  IN NIAGARA  FALLS, NY3
Period/Location
Compound
chlorobenzotrlfluorlde
chlorotoluene
dlchlorobenzotrlf luorlde
dlchloro toluene
trlchlorobenzene
hexachlorobutadiene
trlchlorotoluene
5^ tetrachlorobenzene
pentachlorobenzene
B
ND
ND
ND
ND
ND
ND
ND
ND
ND
P3/L11
ND
ND
ND
ND
ND
ND
ND
ND
ND
P4/L5
ND
427
ND
43
39
54
ND
ND
ND
P4/L6
410°
2,333
ND
113
5,346
T
ND
230
ND
P4/L7
523
527
ND
ND
43
ND
ND
ND
ND
P4/L8
19,586
12,274
193
446
324
389
568
451
17
P4/L10
ND
ND
ND
ND
ND
ND
ND
ND
ND
QSee Table A-14 for sampling protocol.
 B = blank Tenax cartridge.
CValues In ng/tn , ND = not detected, T = trace,

-------
          Table A-22.   ESTIMATED LEVELS OF PURGEABLE HALOGENATED COMPOUNDS IN DRINKING WATER
                               FROM "OLD LOVE" CANAL IN NIAGARA FALLS, NY3
--4
--J
Sample No.
Halogenated Compound
1, 1-dlchloro ethane
chloroform
1, 2-dichloroethane
1, 1,1-trichloroethane
carbon tetrachlorlde
trlchloroethylene
tetrachloroethylene
chlorobenzene
dichlorobenzene isomer(s)
bromod ic hlor oine t hane
chlorodibroinome thane
bromof orm
trichlorobenzene
hexachlorobutad i ene
tetrachloro benzene
pent a chlorobenzene
d 1 cliloropropane
1
_
13,194
45
48
69
214
486
16
92
4,100
87
50
464
55
-
-
-
3
_
17,525
-
75
16
-
350
8
8
3,458
75
16
467
142
1,083
-
-
4
_
6,467
-
8
25
16
608
25
92
6,352
2,133
-
450
75
1,517
-
-
5
_
14,092
-
25
16
8
375
16
83
4,417
6,767
75
575
Tc
1,958
-
-
6
_
9,542
-
417
192
65
2,875
42
825
10,375
3,108
-
542
-
658
-
-
8
—
>24,700
-
16
33
-
650
8
75
4,550
1,400
50
483
167
175
242
-
9
-
4,433
_b
17
-
8
383
58
117
1,758
-
-
325
58
125
-
1,192
10
-
17,495
50
120
88
253
448
16
72
4,498
1,098
60
755
-
-
-
-
     Values  are  ng/fc.   See Table A-10 for sampling protocol.

     Not detected.

     Trace

-------
       Table A-23.  ESTIMATED LEVELS OF PURGEABLE HALOGENATED COMPOUNDS  IN DRINKING WATER FROM
                               "OLD LOVE" CANAL IN NIAGARA FALLS,  NYa
Category Compound
Ubiquitous chloroform
1 , 2-dichloroethane
1,1, 1- tr ichloroe thane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
chlorobenzene
m-dichlorobenzene
o-dichlorobenzene
bromodichlorome thane
chlorodlbromome thane
bromoform
Site-Specific chlorotoluene
dichloro toluene
trichlorobenzene
hexachlorobutadiene
Sample No.
1
13,194b
45
48
69
214
486
16
36
56
4,100
887
50
ND
ND
464
55

10
17,495
<50
120
88
253
448
16
72
ND
4,498
1,098
60
ND
ND
755
ND
3See Table A-10 for sampling protocol, initial tap burst,
 Values are in ng/£, ND = not detected.

-------
Table A-24.  ESTIMATED LEVELS OF PURGEABLE HALOGENATED COMPOUNDS IN DRINKING WATER  SAMPLES
                           FROM NIAGARA FALLS/BUFFALO,  NY AREA3
Compound
chloroform
carbon tetrachloride
1, 1-dichloroethane
1 , 2-dichloroethane
1,1, 1-trichloroe thane
trichloroethylene
bromof orm
chlorodibromome thane
chlorobenzene
m-dichlorobenzene
o-dichloro benzene
bromodlchlorome thane
1 , 2-dichloropropane
chlorotoluene
chlorobenzaldehyde
dichlorotoluene isonier(s)
chloronaphthalene
bromo toluene
dichlorobenzaldehyde
trlchlorobenzene isomer(s)
Locations
LI L2 L3 L4 L5 L6 L7
39,625 29,392 34,600 - 20,667 13,133 18,125
133 108 108 63 25 50 42
_b ______
_ ' _
42 242 150 75 242 42 50
133 92 50 258 50 167 67
67 69 100 142 133 158 167
1,300 908 - 1,333 2,225 1,858 3,533
42 50 83 29 83 33 46
108 183 150 358 125 200 104
15 J 142 - 67 -
12,467 5,517 6,442 3,758 8,450 5,708 10,308
-
______
-------
-------
_______
-------
_______
425 975 492
                                          (continued)

-------
                                     Table A-24 (cont'd.)
                                                           Locations
    Compound                         LI        L2        L3        L4       L5        L6        L7

1,2-dibromoethane                    -         —  '       -         -        -         -         -
trlchlorotoluene                     -    '     -
broraochlorotoluene                   _______
chlorobenzodlchlorofiuoride          -       .  -
1,2-bis(trifluoromethyl)benzene      _______
tetrachlorobenzene                   _______
tetrachlorotoluene                   _______
pentachlorobenzene                   _______
1,3-hexachlorobutadlene               108      -           92
chlorobenzotrifluoride               _______
dlchlorobenzotrlfluorlde             _______
trlchlorotoluene                               -
tetrachloroethylene                   633       908       542       442      225       283       267
 Values are In ng/fc.  See Tables A-14 and A-15 for sampling protocol.
 Not dete~«:ed.

-------
  Table  A-25.   QUANTITATIVE  ANALYSIS  OF EXTRACTABLE  (SEMI-VOLATILE)  HHC ' S IN  TAP WATER
                                           IN BUFFALO/NIAGARA3


                                                        Compounds, ng/1 (ppt)
                       4,4'-dichloro-  2,4' ,5-trlchloro-                 llepcachlor
Samples   Trifluralin  a-BHC   blphenyl       biphenyl      lleptachlor  Aldrln   Epoxide   EndosulCan £,£'-DDE  Dleldcin  j>,£'-DDT  End ill)
H3L5        _.
P3L8        _        _
P3611       __
P3L12       -108
10008
10017
10025
10033
10041
10074
a,.
  Sample size = 120 ml;  detection limit =  5-25  ng/1.   Control:   a-BHC, 1.04  yg, 64% recovery.
  See Tables  A-10,  A-14  and A-15  for  sampling details.

-------
Table A-26.  BODY BURDEN SAMPLING PROTOCOL FOR THE "OLD LOVE" CANAL AREA OF
                             NIAGARA FALLS, NY

j
Location" Date
1
2
3
4
5
6
8
9
10
7/6/78
7/7/78
7/7/78
7/6/78
6/7/78
7/6/78
7/6/78
7/6/78
7/7/78
Urine
Time
1543
0740
0814
1446
0842
1610
1636
1510
0916
Blood
3 tubes
3 tubes
3 tubes
3 tubes
3 tubes
3 tubes
3 tubes
3 tubes
3 tubes
SpGr8
1.
1.
1.
1.
1.
1.
1.
1.
1.
010
033
025
009
016
023
015
009
016
SpGr
NCC
NC
NC
1.020
NC
0.020
1.023
1,014
HC
Breath
3
Volume (m ) Tlme(mln) Temp.°C
0
0
0
0
0
0
0
0
0
.049
.069
.074
.050
.067
.087
.075
.112
.069
7
7
9
12
12
9
10
7
4
30
26
26
30
27
31
31
30
28

Participant
lio.
1
2
3
4
5
6
8
9
10
r\
Early morning sample.
b
00 C
fo None
See
sample at time
collected.
of blood

Figure A- 3 for sampling
collection

locations .
- omitted for






early morning




collection.









-------
                 A-2/.   ESTIMATED LEVELS OF HALOGENATED COMPOUNDS IN HUMAN  BREATH FROM
                              "OLD LOVE" CANAL IN NIAGARA FALLS,  NYS
                                                      Sample No.
Compound 1 2
chloroform 3,896 23,529+11,764
carbon tetrachlorlde - 88+22
1 , 1-dlchloroethane - -
1,2-iHchloroethana - 73+12
1.1,1-tricliloroethana 2,812 264 + 44
trichloroethylene
tetrachloroethylene 750 632 + 294
dluhlorobenzene laomer(a) T 58+0
chloro toluene iaomer(s)
t-1
CO dlchlorotoluene lsomer(8) - 1,220
GJ
cliloronaphchalene laomer(s) - T
bromo toluene isomerfe) ~ T
trlchlorobenzene laotuer(s) - 8fl
chlorobtnzotrlf luorlde luoiner(a) - 852 + 441
tetrachlorobenzene Isotner(a)
pentachlorobenzene - 73
3 45 6 8 9 10
20,424 94,510 23.530 37,447 45,892 36,576 25,591
T 796 + 135 167 + 75 689 + 378 622 90+36 T
T .-J.
T 136 + 75 243 + 108 351
T 286 + 122 394 + 122 329 + 106 - 108 +36 T
T T T - 1.904 T
1,753 1,224 + 285 667 + 75 1,152 + 129 - 658 + 63 4,469
T - - 513
T 755 + 204 - 5,294 338 459 + 72C
261 + 45
_
_
-
T T"
T T - - 27 - T
180
_
 1 . 3-ltexacblorobutadlene
 Values are  in ng/m , duplicates where indicated.   See Table A-26 for sampling  protocol.

 Not detected.


d
CSum for  all isomers.
 T = trace.

-------
    Table A-28.   ESTIMATED LEVELS  OF PURGEABLE HALOGENATED COMPOUNDS IN HUMAN BLOOD SAMPLES
                          FROM "OLD LOVE"  CANAL  IN NIAGARA FALLS, NY
Sample No .
Compound
methylene chloride
chloroform
carbon tetrachloride
1,1, 1-trichloroethane
trichloroethylene
tetrachloroethylene
CD
•£* chlorobenzene
m-dlchlorobenzene
o-dlchlorobenzene
bromodlchloromethane
tetrachlorobenzene
1
25,200
1,450
45
2,000
-
350
600
150
-
2
2,700
1,100
95
550
100
850
50
2,450
—
-
3
850
1,150
110
250
200
900
100
1,300
:
-
4
28,350
2,050
85
550
300
22
1,100
3,000
250
-
5
14,200
3,050
140
500
100
1,200
50
2,200
200
-
6
8,050
1,550
40
850
~
500
50
2,550
200
-
8
2,650
20,100
-
1,650
-
255,550
16,800
67,700
14,250
-
9
l,150a
1,550
70
950
2,550
1,000
100
1,300
350
b
2,600
10
2,050
1,050
75
1,800
150
900
50
750
	
-
Values are ng/£.  See Table A-26 for sampling protocol.

Not detected.

-------
             Table A-29.  ESTIMATED  LEVELS  OF PURGEABLE HALOGENATED COMPOUNDS IN HUMAN URINE SAMPLES

                                      FROM "OLD LOVE"  CANAL,  IN NIAGARA,  NY3
oo
Ul
Category
Ubiquitous






Site-Specific

Compound
chloroform
1, 2-dichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
chlorobenzene
m-dichlorobenzene
chloro toluene
bromo toluene

1
l,460b
ND
96
220
140
ND
39,160
ND
ND

2
780
ND
68
550
120
ND
893
(160)
(160)
Sample No.
3
460
ND
62
318
120
17
36
ND
MD

5
800
ND
100
320
140
20
40
ND
ND

10
800
ND
120
400
146
ND
ND
MD
ND
          See Table A-26  for  sampling  protocol,  early morning collection.

          JValues  in ng/1,  ( )  =  near detection limit,  ND = not detected.

-------
         Table A-30.  ESTIMATED LEVELS OF PURGEABLE HALOGENATED COMPOUNDS IN HUMAN URINE SAMPLES
                               FROM "OLD LOVE" CANAL IN NIAGARA FALLS, NY3
00
ON
Compound
chloroform
carbon tetrachloride
1, 1-dichloroethane
1, 2-d±chloroethane
1,1, 1-trichloroethane
trlchloroethylene
tetrachloroethylene
bromoform
chlorodlbromomethane
chlorobenzene
m-dichlorobenzene
o-dlchlorobenzene
bromodlchloromethane

4
867
42
-
75
92
42
550
-
-
67
758
142
-
Sample No.
6 89
1,250 1,085 858a
150 , 62 92
c
50 -
183 146 158
L- 67 92 50
692 425 392
_
_ _
117 50 92
708 475
725 108
_

Control
169,440b
-
-
-
-
-
2,883
-
-
658
1,250
-
-
     Values  in  ng/£.   See Table A-26 for sampling protocol.

     Quantity observed In spiked urine samples.
     'Not  detected.

-------
00
              m&^^m
              igap^'***"
               \ \»-f'4
               -/ t -p^i
^


                                                                              cr^i
                                                                               o>
                                                                               o
                                                                               Q.
                                                                &
                                                                o
                                                                •o
                                                                Z.M^-	,
     Figure A-ll.  Northern New Jersey, showing general sampling sites, Trip 2 (September, 1978)

-------
CO

00
                                                          j
K;•1 T?-*i'Sik-jassi™

?y^pa^i%r^
SjiSj&ftteKS jfnE JGB
                       I 5TI^!. v   /  VWvfft' __-»f?tlt»> -^T f. I v.-i
                      f-r^- ^r^fnf \^2£Mi
                      /  T—^/.«.'«»^ /;  "   II I—rr  \\\


-------

                                                                  //   •-->,  /;rcf

                                                        Tl    W\

1       H       1       J        I




 Figure A-13.   Map of Rahway,  NJ area showing  Site No. 2 and  the sampling locations.
                                                                                                   CD (T>


                                                                                                   ""*" -t

                                                                                                   n, O
                                                                                                  n
                                                                                                  o 3
                                                                                                  -o

-------
Reproduced from

best availablecopy.
                                                   nytTL.* -'^"D 3 n'trfa x x-
££ K Wffij * t'l&TtJ'W
^W^^^BW'
'j&ffmQnM^

 ,;»'   /A'/'''^VN

    Fig-are A-14.   Map of Hillside, NJ area,  showing Flash Dry Cleaners

                  (FDC) and sampling locations.
                                     190

-------
                                                                                                     crx>

                                                                                                     (T> (D
                                                                                                      -
                                                                                                     —. o


                                                                                                     Is-
                                                                                                     (5 -—

                                                                                                     n °
                                                                                                     o 3
                                                                                                     n
                                                                                                     -<
Figure A-15.   Map of Edison, NJ area showing Site  No.  3  and sampling locations.

-------

Figure A-16.  Map  of  Fords,  NJ area showing Site No. A and  sampling locations.

-------
                                              Reproduced from
                                              best available copy.
                        !& o H,A- f&
                                    ^M$iOpS^-/ £ A ': 'jr^&f
                                    \l>,M^*3^/^:>>£*>   _<>? //.xc  '  ,':a:~yw
                                        -
• ?"•->".V«..«!.... -«.. ^^^
rt^-y^^f&f /
* ''?$X'&< '•.-*&< H*
                                                   "^•5-*'?%,f3E
                                                   ^-V>.  - '-'.^••.,-^i.
 Figure  A-17.   Map of Rutherford, NJ area showing Site No. 5 and  sampling
               locations.
                                    193

-------
        Table A-31.  SAMPLING PROTOCOL FOR SITE NO.  1,  BOUND BROOK,  NJ  - TRIP  2
Period
PI
(9/18-9/19/78)






P2
(9/19-9/20/78)





P2
(9/19/78)
Location
LI
L2
L3
LI
L5
L6
L7
L8
LI
L2
L3
L4
L5
L6
L8
L5

Sampling Time
11A8(9/18)-1615(9/19)
1015(9/18)-1634(9/19)
0930(9/18)-155'i(9/19)
1206(9/18)-1505(9/19)
0915(9/18)-1237(9/19)
0955(9/18)-1330(9/19)
1038(9/18) - unknownc
1110(9/18)-1310(9/19)
1615(9/19)-unknownc
1640(9/19)-0955(9/20)
1600(9/19)-unknown°
1508(9/19)-unknownc
1245(9/19)-1113(9/2d)
1335(9/19)-10A5(9/20)
1320(9/19)-1100(9/20)


Sampling
Volume(l)
115a'b
109a'b
6t,"'b
1078>b
123a'b
124a>b
unknown
133a'b
unknown
59a,b
unknown
unknown
ioia-b
93a'b
95a'b
3x120 mld

Meteorological Conditions
Type of Sample T (°C) % Rll Wind Dir. /Speed (Kn>/hr) Other
Air 12-22 69-100, H-NNE/0-3 Rain evening of 9/18
Air
Air
Air
Air
Air
Air
Air
Air 10-15 62-89 NHE/0-3
Air
Air
Air
Air
Air
Air
Tap Water

Volume of air/cartridge
Sampling time x flow rate
Pump failure during sampling period
Samples taken Immediately after turning on tap

-------
             Table A-32.   SAMPLING PROTOCOL FOR  SITE NO.  2, RAHWAY,  NJ -  TRIP 2
Period
P3
(9/20-9/21/78)





PA
(9/21-9/22/78)


P3
(9/20/78)
PA
(9/21/78)
Location
LI
L2
L3
LA
15
L6
L7
LI
L2
L3
LA
L5
L6
L7
L3

L2

Stapling Tine
1A15(9/20)-1350(9/21)
lA35(9/20)-unknownC
1A52(9/20)-1S35(9/21)
155A(9/20)-1558(9/2l)
1635(9/20)-1A11(9/21)
1650(9/20)-1A11(9/21)
1735(9/20)-1A5B(9/21)
UOO(9/21)-llA8(9/22)
1522(9/21)-l200(9/22)
15AA(9/21)-1228(9/22)
1605(9/21)-1212(9/22)
lA20(9/21)-1239(9/22)
!A15(9/21)-12A8(9/22)
1500(9/21)-1319(9/22)




Sampling
Voluoe(l)
1061'"
unknown
971>b
91*'b
89*>b
81*lb
M-,b
9l..b
83' 'b
83' '"
88a'b
98».b
1011'11
M.,b
3x120 ml*

3x120 ml"

Meteorological Condition*
Type of Sample T ("C) X RH Wind Dlr. /Speed (Kn/hr) Other
Air td-28 A9-77 t - W/0-13
Air
Air
Air
Air
Air
Air
Air 19-28.5 60-86 WSU-N/0-13.5

Air
Air
Air
Air
Air
Tap Water

Tap Water

  Volume of air/cartridge
|j
  Sanpling time x  flow rate

  Pump failure during sampling period

  Weather data non-existent for before 1300 on 9/21

  Saaplea taken immediately after turning on tap

-------
             Table A-33.  SAMPLING PROTOCOL  FOR SITE  FDC  (FLASH DRY CLEANERS),
                                          HILLSIDE, NJ -  TRIP 2
   Period
              Location
                           Sampling Time
Sampling
Volume(l)  Type of Sample  T (°C)
                                                                               Meteorological Conditions
Wind Dir./Speed (Km/hr)
                                                                                                              Other
  P4
(9/21/78)
LI    1150(9/21)-1210(9/21)     25

12    1150(9/21)-1210(9/21)     33
                                               s,c
              Air

              Air
                                                                    26
    WSW/10-20
  Volume of air/cartridge
  Upwind sample
  Downwind sample

-------
                 Table A-34.  SAMPLING PROTOCOL FOR SITE NO. 3, EDISON, NJ - TRIP 2
Period Location Sampling Time
P5
(9/22-9/23/78)






P6
(9/23-9/24/78)





P6
(9/23/78)

P7
(9/24/78)

l'8
(9/25/78)
LI

L2
L3
L4
L5
L6
L7
LI
L2
L3
L4
L5
L6
L7
L4
L5
L6
L2
L3
L7
LI

1555(9/22)-1415(9/23)

1630(9/22)-1500(9/23)
1705(9/22)-1525(9/23)
1759(9/22)-1749(9/23)
1832(9/22)-1815(9/23)
1725(9/22)-1707(9/23)
1639(9/22)-1625(9/23)
1423(9/23)-1445(9/24)
1507(9/23) -1517(9/24)
1537(9/23)-1535(9/24)
lB05(9/23)-1628(9/24)
1829(9/23)-1612(9/24)
1715(9/23)-1649(9/24i
1630(9/23)-1721(9/24)








Sampling
Volume(l) 1
93a'b

93a'b
B5a'b
unknown
95a'b
90a'b
91a'b
105" >b
98a'b
658>b
unknown
85a>b
unknown
73a'b
3x120 0!*!
3x120 ml"
3x120 ml
3x120 ml"!
3x120 »i~.
3x120 s.1
3x120 mld

Meteorological Conditions
Type of Sample T (°C) I RH Wind Dir. /Speed (Ka/hr) Other
Air 13-20 80-90 NNE-ESE/5-20 Rain during 9/22
evening
Air
Air
Air
Air
Air
Air
Air 10-20 47-93 Variable/calm to 18
Air
Air
Air
Air
Air
Air
Tap Water
Tap Water
Tap Water
Tap Water
Tap Water
Tap Water
Tap Water

Volume of air/cartridge
Sampling time x flow rate
Pump failure during sampling period
First and second samples taken immediately after turning on tap; third sample after 2 mln. run

-------
                     Table A-35.  SAMPLING PROTOCOL FOR SITE No. 4, FORDS, NJ - TRIP 2
VD
00
Period
P8
(9/25-9/26/78)





P9
(9/26-9/27/78)




P8
(9/25/78




Location Sampling Time
LI
L2
L3
L4
L5
L6
L7
LI
L2
L3
L5
L6
L7
L2
L3
L4
L5
L6
L7
0815(9/25)-0802(9/26)
0915(9/25)-unknown°
0940(9/25) - unknown0
1005(9/25)-unknownC
1025(9/25)-1040(9/26)
1045(9/25)-1035(9/26)
1130(9/25)-1102(9/26)
0815(9/26)-0920(9/27)
0844 (9/26) -unknown0
0908(9/26)-0945(9/27)
1048(9/26)-1015(9/27)
1040(9/26)-1030(9/27)
1114(9/26)-1100(9/27)


'



Sampling
Volume(l) Tj
95a'b
unknown
unknown
unknown
94a'b
101a'b
74a'b
113a'b
unknown
95" 'b
93a'b
99a'b
87a'b
3x120 mld
3x120 mld
3x120 mld
3x120 mld
3x120 mld
3x120 rold
Meteorological Conditions
rpe of Sample T (°C) % RII Wind Dir. /Speed (Km/hr) Other
Air 8-23 45-70 NNW-NE/9-29
Air
Air
Air
Air
Air
Air
Air 9-18 45-60 Variable/calm-18
Air
Air
Air
Air
Air
Tap Water
Tap Water
Tap Water
Tap Water
Tap Water
Tap Water
     Volume  of  air/cartridge
     Sampling time x flow rate
     Pump  failure  during sampling period
     First and  second samples taken immediately after turning on tap;  third after 2 min run
     Samples taken immediately after turning on tap

-------
                  Table A-36.  SAMPLING PROTOCOL FOR SITE No.  5,  CARLSTADT,  NJ  -  TRIP  2
Period
P10
(9/28-9/29/78)





Pll
(9/29-9/30/78)





P12
(9/30/78)
P10




PU
(9/29/78)
Location
LI
L2
L3
LA
L5
L6
17
LI
L2
1.3
LA
L5
L6
L7
i.a
L9
L2
LA
L5
1.6
L7
LI

Sampling Time
UA2(9/28)-1211(9/29)
1219(9/2B)-12A5(9/29)
1257(9/2B)-unknownC
1322(9/28)-13A5(9/29)
1511(9/28)-lA30(9/29)
1625(9/28)-1518(9/29)
170A(9/28)-1606(9/29)
1226(9/29)-1222(9/30)
12S8(9/29)-unknownC
1331(9/29)-1258(9/30)
1356(9/29)-1312(9/30)
lAAO(9/29)-1323(9/30)
1538(9/29)-13A3(9/30)
1627 (9/29)- 1A02(9/30)
1117-1U8
1115-11A5







Sampling
Volume (1)
90a>b
97"'b
unknown
loia-b
85a>b
80a'b
82a.b
93a'b
unknown
107a'b
97a'b
86a'b
79a'b
na.b
35a,b,d
35a,b,e
3x120 ml
3x120 ml
3x120 ml
3x120 ml
3x120 ml
3x120 ml

Meteorological Conditions
Type of Sample T (°C) % R1I Wind Dir. /Speed (Km/hr) Other
Air 3-22 38-91 NW-NE/calm-29
Air
Air
Air
Air
Air
Air
Air 7-21 31-100 Variable/calm-2fl
Air
Air
Air
Air
Air
Air
Air 19 53 S/28
Air
Tap Water
Tap Water
Tap Water
Tap Water
Tap Water
Tap Water

Volume of air/cartridge
Sampling time x flow rate
Pump failure during sampling period
Upwind "grab scale"
 ownwind "grab scale"

-------
t-0
O
o
          4J
          •H
          OT
          0
          M
          aS
          rH
          <
                                                        Mass Spectrum No.
          Figure A-18.   GC/MS/COMP profile of vapor-phase organics  in  ambient air at Site No. 1 in
                        Bound Brook, NJ (PI/LI).  See Table A-38.

-------
(0

a
Hi
4J
p, .....
>

•H

4J

nJ
                                         Mass  Spectrum No.
     Figure A-19.  GC/MS/COMP profile of vapor-phase organics in ambient air at  Site  No.  1 in

                   Bound Brook, NJ  (P2/L4).   See Table A-37.

-------
O
N5
                  i1

                                          k'   "fc'	k'	k1.	K	V	V

                                                    Mass  Spectrum  No.
                Table A-20.  GC/MS/COMP profile of vapor-phase organics in ambient air at Site No. 2 in
                             Rahway, NJ (P3/L7).  See  Table  A-39.

-------
ro
O
U>
                                                     Mass Spectrum No.
               Table A-21.  GC/MS/COMP profile of vapor-phase organics in ambient air at Site No.  2  in

                            Rahway, NJ (P4/L2).   See Table A-40.

-------
N>
O
-P-
 I
CP


4i
u. ffiP
                                                             WVJ
                                                            Mass  Spectrum No.
                    Figure A-22.  GC/MS/COMP profile of vapor-phase  organics  in ambient air at Site No. 2 in
                                  Rahway, NJ (P3/L3).  See Table A-41.

-------
a
        4-1


        W


        0)
        4-1
        Pt
4J
cd
                             • If.*    »f
                                                                                             >/»•    »7t
                                                  Mass Spectrum No.
              Figure A-23.  GC/MS/COMP profile of vapor-phase organics in ambient  air  at Site No. 3 in
                            Edison, NJ  (P6/L5).   See Table A-42.

-------
(0
o
                                                       Mass  Spectrum No.
                       Figure A-24.   GC/MS/COMP profile of vapor-phase organlcs  In ambient air at Site No.  4

                                     in Edison, NJ (P6/L6).  See  Table A-43.

-------
o
                4-1

                •rl
                W
                 cd
                ,-1
                 0
                                                   Mass Spectrum No,
Figure A-25.
                                  GC/MS/COMP profile of vapor-phase organics in ambient  air at Site No. 4

                                  in Fords,  NJ (P8/L1).  See Table A-44.

-------
NJ
O
00
                 •H
                 OT
                 C!
                  ;:
                             sri*    |3<
                                     .' T»1 •prf.-T f-T*"'"*'

                                     •    »3'.«
                                                         Mass Spectrum No.
                      Figure A-26.  GC/MS/COMP  profile  of vapor-phase organics in  ambient  air at  Site No.  4
                                     in  Fords, NJ (P9/L3).  See Table A-45.

-------
                                               T—T
                                   Mass Spectrum No.
Figure A-27.  CC/MS/COMP profile of vapor-phase organics in ambient air at Site No.  5
              in Carlstadt, NJ (P10/L7).   See Table A-46.

-------
N>
M
O
I'-

ll!
                                      lui
                                                   Mass Spectrum No.
           Figure A-28.   GC/MS/COMP profile of vapor-phase organlcs in ambient air at Site No. 5 in
                         Carlstadt, NJ (P11/L4).   See Table A-47.

-------
    Table A-37.  VAPOR-PHASE HALOGENATED ORGANICS  IDENTIFIED  IN
        AMBIENT AIR AT SITE NO. 1 IN BOUND BROOK,  NJ  (P2/LA)a
ChroBico-
iraphlc
?t*k No.
2
5
7
3
11
13
15
17
Elution
T««p.
CO
55.7
65.7
70.7
71.7
83.0
3S.O
38.3
9X.3
Coopound
Freon 12 (BKC)
Freon 11 (BKC)
CH2C12
Freon 113
PFB (I)
CHC13
?FT (I)
1,1. 1-CTlehloroethane
Chromaco-
grapnic
Peak Ho.
19
22
33
36
49
51
53

Eluclon
Temp.
. Cci..
95.7
102.7
127.0
134.0
143.3
165.7
170.3

Compound
cci4
trichloroethylene
tecrachloroechylene
chlorobenzene
C-H ,Br
dlchlorobanzeoe isomer
dichlorobenzene isomer

±See Table A-31 for sampling protocol.
   Table A-38.  VAPOR-PHASE  HALOGENATED ORGANICS  IN  AMBIENT  AIR  AT
               SITE NO.  1 IN BOUND  BROOK,  NJ  (Pl/Ll)a
Chroma co-
iraphic
Peak No.
2
9
11
12
15
17

Elution
Temp.
CC)
55.3
71.9
77.4
79.6
91.5
93.3

Compound
Freon 12 (BKG)
Freon 11 (BKC)
CH2C12
Freon 113
PFB (I)
CHC13

Chromaco-
graphlc
Peak No.
19
21
23
27
38
40
50
Elution
Temp.
CC)
97.0
100.0
103.7
109.3
121.3
137.3
167.3
Compound
PFT (I)
1,1, 1-crlchloroethane
CC1.
•4
trlchloro«chylene
teCTachloro«chylane
chloro benzene
dichlorobenzene isomer
See Table A-31 for sampling protocol.
                                  211

-------
      Table A-39.  VAPOR-PHASE HALOGENATED ORGANICS IDENTIFIED  IN
       AMBIENT AIR AT SITE NO. 5 IN RAHWAY, NJ (P3/L7)3- TRIP. 2
Chromaco-
graphic
Peak No.
5
6,7
9
10
15
16
17
17a
Elution
Temp.
co
71.3
74.5
82
86.2
94
96.4
99.0
101.4
Compound
CF2C12 (Freon 12)
CFClj (Freon 11)
methylene chloride
CF2C1CFC12 (Freon 113)
PFB (I)
CHC13
PFT (I)
1 , 2-dichloroethane
Chromaco-
graphic
Peak No.
18
20
26
42
69
72
95
99
Elution
Temp.
co
103.0
107.0
114.6
142.8
190.2
195.3
226.6
233.8
Compound
1,1, 1-trichloroethane
cci4
trichloroethylene
tetrachloroethylene
dichlorobenzene isomer
dichlorobenzene isomer
trichlorobenzene isomer
trlchlorobenzene isomer
See Table A-32 for sampling protocol.
      Table A-40.   VAPOR-PHASE HALOGENATED ORGANICS IDENTIFIED IN
           AMBIENT AIR AT SITE NO.  2 IN RAHWAY, NJ (P4/L2)a
Chroma co-
graphic
Peak No.
4
6
9
10
16
17
19
20
Elucion
Temp .
CO
71.9,
74.6
79.8
80.4
91.9
94.2
97.7
100.2
Compound
Freon 12 (BKG)
Freon 11 (BKG)
CH2C1,
Freon 113
PFB (I)
CHC13
PFT (S)
1,1,1-crichloroethane
Chromato-
graphic
Peak No.
22
27
40
44
71
75
102

Elution
Temp.
CO
105.2
113.2
141.7
149.7
189.2
195.0
226.2

Compound
cci4
trichloroethylene
tetrachloroethylene
chlorobenzene
dichlorobenzene isomer
dichlorobenzene isomer
trichlorobenzene isomer

See Table A-32 for sampling protocol.
                                  212

-------
   Table A-41.  VAPOR-PHASE HALOGENATED  ORGANICS  IDENTIFIED  IN
        AMBIENT AIR AT SITE NO.  2  IN  RAHWAY,  NJ  (P3/L3)a
Chronaco-
jraphic
P««k NO.
2
7
9
10
15
16
17
17a

Eluclon
CC)
63.4
76.0
31.2
82.3
93.8
96.1
99.6
101.7

Compound
Freon 12 (EKC)
Fr«on 11 (BKC)
Freon 113
TO (S)
CHC13
prr (i)
1 ,2-dichlorocthana

Chromaco-
graphic
Peak No.
13
20
24
34
38
42
66
70
86
Eluclon
Temp.
CO
102.6
107.3
114.8
127.0
142.6
150.6
190.0
195.4
227.0
Compound
1,1, 1-crlchloroechane
CC1,
crlchloroechylene
1,1,2-crlchloroechane
tecrachloroethylene
chlorobenzene
dichlorobenzene Isomer
dlchlorobenzene Isomer
crichlorobenzene laoaer
See Table  A-32  for sampling protocol.

-------
         Table A-42.   VAPOR-PHASE HALOGENATED ORGANICS IDENTIFIED IN
               AMBIENT AIR AT SITE NO.  3 IN EDISON,  NJ (P6/L5)a
Chromato-
graphic
Peak No.
2
4
5
8
11
12
14
Elution
Temperature
66.3
74.9
72.9
82.9
85.9
89.6
92.3
Compound
Freon 11 (BKG)
CE2C12 (BKG)
Freon 113
PTB (I)
CHC13
PFT (S)
1,1, 1-trichloroethane
graphic
Peak. Ho.
16
19
29
31
46
49

Temperature
CO
-96.3
103.2
126.7
133.7
164.6
168.8

Compound
CC1,
trichloroethylene
tetrachloroethylene
chlorobenzene
dichlorobenzene isomer
dichlorobenzene isomer

See Table A-34 for sampling  protocol.
          Table A-43.   VAPOR-PHASE  HALOGENATED ORGANICS IDENTIFIED IN
              AMBIENT  AIR AT SITE NO.  4 IN EDISON,  NJ (P6/L6)S
Chromaco-
graphic
Peak No.
1
3
5
6
9
11
12
13
Elution
Temp.
rc>
56
64.6
70
71
82.2
84.6
88.3
90.0
Compound
Freon 12 .(BKG)
Freon 11 (BKG)
CE2C12
Freon 113
PFB (I)
CHClj
PFT 
-------
     Table A-44.  VAPOR-PHASE HALOGENATED ORGANICS  IDENTIFIED  IN
      AMBIENT AIR AT SITE NO. 4 IN FORDS, NJ  (P8/Ll)a -  TRIP 2
Chrooaco-
graphic
Peak No.
3
6
9
10
13
15
17
Elucion
Temp .
CO
55.7
65.7
70.7
72.0
82.7
85.3
88.7
Compound
Freon 12
Freon 11
mechylene chloride
Freon 113
PTB (I)
chloroform
PFT (t)
Chroma co*
graphic
Peak No.
19
21
25
36
55
58

• Elucion
Temp.
CO
92.0
96.0
102.7
127.0
166.0
170.3

Compound
1,1, 1-crichloroechane
carbon cetrachloride
crlchloroechylene
cecrachloroechylene
dichlorobenzene isoner
dichlorobenzene isotner

See  Table A-35 for  sampling  protocol.
      Table A-45.  VAPOR-PHASE  HALOGENATED ORGANICS  IDENTIFIED IN
           AMBIENT AIR AT SITE NO.  4 IN FORDS,  NJ (P9/L3)
Chroaaco-
graphic
Peak No.
4
8
11
12
16
18
20
Elucion
Temp.
CO
55.7
66.0
71.0
72.3
83.3
85.3
89.0
Compound
Freon 12 (BKG)
Freon 11 (BKC)
CH-C1,
Freon 113
?FB (t)
CHC13
PFT (1)
Chromaco-
graphic
Peak No.
22
25
29
41
57
59
Elucion
Temp .
CO
91.7
96.0
102.7
126.3
164.3
168.7
Compound
1,1,1-crichloroechane
cci4
crichloroethylene
tetrachloroechylene
dichlorobenzene isomer
dichlorobenzene isomer
 See Table  A-35  for  sampling protocol,
                                  215

-------
    Table A-46.   VAPOR-PHASE HALOGENATED ORGANICS IDENTIFIED IN
       AMBIENT AIR AT SITE NO.  5  IN CARLSTADT,  NJ (P10/L7)
Chrtmaco-
graphic
2
3
8


11
15
17
18
Elucion
Temp.
63.3
63.6
74.5


81.5
92.7
99.3
101.2
Compound
Freon 12 (BKG)
dichloroethylene
Freon 11


Freon 113
P7B (I)
P7T (I)
1,1,1-crichloroe thane
Chromato-
graphic
Peak No.
20
25
35
40

56
59
69

Elucion
Temp.
CO
106.0
113.4
141.2
149.2

187.8
192.9
223.1

Compound
CGI,
trichloroethylene
tetrachloroethylene
chlorobenzene

dichlorobenzene isomer
diehlorobenzene isomer
trichlorobenzene isomer

See Table A-36 for sampling protocol.
    Table A-47.  VAPOR-PHASE HALOGENATED ORGANICS IDENTIF^^D IN
       AMBIENT AIR AT SITE NO. 5 IN CARLSTADT, NJ (P11/L4)
Chromaco-
graphic
Peak Ho.
1
5
7
8
14
15
17
17a
Elucion
Temp.
CC)
63.4
74.6
80.6
81.2
92.7
94.6
98.8
IOC. 6
Compound
Freon 12 (BKG)
Freon 11 (BKG)
nethylene chloride
Freon 113
PFB (I)
CHC13
PTT (S)
1 , 2-dichloroethane
Chroma co-
graphic
Peak No.
18
20
24
31
38
63
67
86
Elution
Temp .
CO
100.9
106.2
113.8
126.8
141.7
189.5
194.3
224.9
Compound
1,1, 1-trichloroethane
CCl,
crichloroethylene
1,1,2-crichloroethane (cent.)
tecrachloroethylene
dichlorobenzene isoner ,
dichlorobenzene isomer
trichlorobenzene isomer
See Table A-36 for sampling protocol.
                                 216

-------
        Table  A-48.
                     ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED HYDROCARBONS IN AMBIENT AIR AT

                             SITE NO.  1 IN BOUND BROOK,  NJ (9/18 - 19/78)3

-------
              Table A-49.  ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED HYDROCARBONS IN AMBIENT AIR AT

                                    SITE NO. 1 IN BOUND BROOK,  NJ (9/19-20/78)a
Category Conpound
Ublqultoua 1,1-dlchloroethana
chlorofona
1,2-dlchloroe thane
1,1,1-trlcliloroe thane
carbon tetrachlorlde
tcichlorocthylene
tetrachloroethylene
•-JichlorobenianB
o-dtchlorob«nzen«
P2/L1
ND
5,111
612
6,415
2,333
7,457
10,286
2 343
800
657
+
•»•
±
4-
•f
+
-f

+
b
555
97
512
370
629
1,057
286
143
86
P2/L2 P2/L3
ND .
3,694 j
581 +
5,756 +
1,778 +
3,075 +
5,051 +
746 +
661 +
390 *
ND
472 10,750 + 4,083
64 742 -I- 161
49 5,439 + 561
0 1,519 ± 74
552 5.179 ± 1,612
627
85
51
34
P2/L4
NJ
2.278
355 + 0
4,854 ± 439
1,259 + 0
3,925 + 567
8,429
2 071 + 536
821 + 0
893 + 36
P2/L5
T
3,694
452
8.634
2.333
6,149
7,436
158
327
99
+
±
•f
+
+

+
±
667
32
293
148
627
802
59
9.9
9.9
P2/L6
ND
3,611
581 + 32
8,634 + 34
2,296 + 667
3,881 + 149
8.075 + 591
366 + 86
613 + 22
140 + 0
F2/L8
ND
6,167 ± 278
323 ± 97
2,537 + 732
1,000 + 259
1.672 + 194
1,274 + 168
263 + 105
147 + 21
95 ± 21
NO
M
o°             a
               See  Table A-31 for sampling protocol.

               Values  are in ng/m ,  ND = not detected,  T = trace, — not determined.

-------
Table A-50.
             ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED  HYDROCARBONS IN AMBIENT AIR AT SITE NO. 2

                                 IN RAHWAY, NJ  (9/20  -  21/78)3
Category
Ubiquitous








Slt*-Sp«clftc
Conpoun4
chlorofora
1 . 2-dlchloroethane
1,1.1-trlchlorocthane
carbon tetrachlorid*
trichloroethylen*
tecrichloroethyleue
chlorobenzene
jr-illchlorobenien«
&-dlchlorob«ni in*
tr Ichlorobuaxn*
P3/L1
10.091 t 1.227*
1,345 t 275
14,923 t 3.000
2.789 1 579
8.114 t 2.083
19.660 t 7.094
283 t 123
170 t 113
207 t 38
179 t 132
P3/L2
7.409
2.000 1 137
20.000 t 1.153
3,842 t 105
11.520 t 1.646
21,181 t 1.771
578 t 217
410 t 24
337 t 156
156 t 24
P3/L3
17
1.586
19.115
3,181
12.000
9,691
670
484
299
113
,318
t 207
t 153
t 105
t 1,562
t 587
t 391
t 0
t 123
t 21
P3/L4
10
1.379
15.615
2.579
9.583
9.747




.181
* 517
t 2.615
t 684
t 4.208
t 3.198
98
132
88
33
P3/L5
20,409
1,810
22.692
2,737
48,646
13.876
550
696
1.438
180
t 1.864
t 275
t 3.385
t 421
1 6.250
t 2,213
t 292
t 135
t 326
t 45
P3/L6
8.727 i 3,318
2.034 t 172
31.461 t 8,154
3,684 t 789
21,354 t 1.208
21,469 t 901
1.222 t 518
580 * 86
1,506 t 309
222 t 25
P3/L7
38.636 t
1.241 t
24.154 t
3.368 t
16.375 t
33.050 t
414 t
525 t
11,555 1
353 *
3.136
655
846
158
417
2.555
71
40
768
50
 a

  See Table A-22 for sampling protocol.
 V              n

  Values in ng/m , - = not detected, T = trace.

-------
            Table A-51.  ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED HYDROCARBONS IN AMBIENT AIR AT
                                     SITE NO. 2  IN  RAHWAY, NJ  (9/21-22/78)3
KJ
KJ
O
Cat«|ory
Ubiquitous








Slt»-
apeclf Ic
Compound
chloroform
1,2-dlchloroe thane
1,1,1-trlchloroe thane
carbon tetrachlorlde
trlchloroethylene
tetrachloroethylene
ehlorobenzene
n-dlchlorobenzene
o-dlchlorobenzene
trlchlorobenzene
Site No. 2
P4/L1
1
98,625 + 2,815
3,200 + 0
47,100 + 3,300
4,071 + 71
173,886 + 2,600
35,198 + 1,077
747 + 0
967 + 0
2,154 + 374
450 + 33
P4/L2
1
32,750 +
4.300 +
38,400 +
4,000 +
48,743 +
44,446 +
807 +
951 +
446 +
554 +
5,000
0
600
0
1.514
277
24
24
12
24
P4/L3
34.000 +
3,050 +
46,200 +
3,571 +
38,914 +
32,108 +
711 +
915 +
361 +
373 +
17,312
50
3.100
143
3,400
13,807
72
12
72
217
P4/L4
22,250 +
2,400 +
31,150 +
4,143 +
26.600 +
20,000 +
518 +
651 +
253 +
102 +
11.750
100
3,900
500
285
301
205
132
12
6
P4/L5
17,125 + 625
3,900 + 200
51,200 + 11,200
5,643 + 2,000
121,886 + 4,857
25,510 + 2.964
1,132 + 181
1,855 + 385
9,807 + 1.638
415 + 108
P4/L6
29,125 + 16,
4.800
53,900
8,214
178.229
39,881
1,505
1.752
2,604
495
P4/L7
500 38,812 + 11,062
3,375 + 9
41,400 + 200
29,571 + 143
103,057 + 8.028
38,359 + 4,180
888 + 90
904 + 112
10,438 + 1,438
494 + 67
            See Table A-32 for sampling protocol.
           i              ^
            Values In ng/m , — = not detected, T = trace.

-------
               Table A-52.   ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED HYDROCARBONS IN AMBIENT AIR
                                      AT SITE NO.  3 IN EDISION, NJ (9/22-23/78)
l-o
NJ
C*t»i 0
26,364 + 0
282 + 59
282 *; 59
671 + 3)
212 + 12
r$/u
HD
T
HD
T
HD
T
T
HD
T
T
rs/ts
HD
3.116 + 419
1,714 + 428
»,889 * l.SOO
5,083 + 210
14,218 + 4.167
10,074 ± 8)2 *
210 i 0
600 + 1)8
274 i 21
f)/L6
T
6.83* + 3.322
4.)71 + 1.03)
10. 679 + 678
4.542 + 2)0
27.2)0 + 2.37)
8.232 + 3.000
30) ± *4
368 + 74
242 * 11
r)/L7
HD
).290 + 1.097
HD
1.500 + 71
T
T
421 + 0
T
1)8 + 0
HD
             See  Table A-34 for sampling protocol.
            i                   o
             Values are in ng/m , ND = not detected, T = trace.

-------
     Table A-53.  ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED HYDROCARBONS IN AMBIENT AIR
                           AT SITE NO. 3 IN EDISON, HJ (9/23-24/78)3
Category Compound
Ubiquitous l,l~dichloroethane
chlorof oro
1,2-dlchloroethane
1,1,1-trlchloroethane
carbon tecrachlorlde
trlchloroethylene
tetrachloroethylene
chlorobenzene
»-dlchlorobenzen«
o-dlchlorobenrene
P6/L1
HDb
9,086 + 2,028
3,839 + 484
18,195 + 1,171
12,852 + 667
89,985 + 3,388
8,752 •»• 705
2,971 + 114
790 + 95
1,333 + 124
P6/L2
ND
6.943 +
3,742 +
5,829 +
3.370 +
5,089 +
7,163 +
2,306 +
1,418 +
1,163 ±

2.828
548
512
222
0
571
61
408
0
P6/L3
T
8.600
7.226
7,756
3,852
6,373
8,031
2.354
1,123
1,646
P6/L4
ND
5,857
710
9,219
2,926
2.970
18.857
536
2.107

+ 1,171
+ 64
+ 634
+ 444
+ 44
+ 2,000
± n
± °
T
P6/L5
NT
4,314 -4-
806 +
6,707 +
2,259 +
5,940 +
6,647 +
529 +
647 +
247 ±
P6/L6
m
0
32
244
518
0
952
82
153
0
6,443
772
6,732
4,259
5,522
5,745
564
904
308
± 1.457
+ 64
1 927
+ 889
+ 850
± 1,649
± °
+ 85
± 53
F6/L7
HD
7.714 + 1,257
1,484 + 290
7.610 + 1,341
8,444 + 1,000
5.507 ± 418
5.699 + 1.438
1.041 + 301
767 ± 232
493 + 96
3See Table A-34 for sampling protocol.
i                   O
 Values are In ng/m , ND = not detected, T = trace.

-------
               Table A-54.  ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED HYDROCARBONS IN AMBIENT AIR
                                     AT SITE NO. A IN FORDS, NJ  (9/25-26/78)a
U>
Category Compound
Ublqultoue 1,1-dlchloroethane
chlorofora
1 . 2-d Uhloroathane
1,1,1-trlchloroethane
carbon tatrachlorlde
t rlchloroethylene
tetrachloroethylene
chlorobenxene
•-dlchlorobenzcnc
o-dlchlorobeniene
P8/L1
P8/L2
HDb ND
11.419
609
10.555
3.889
5.940
2.179
263
432
189
+
+
+
+
+
+
+
+
+
6.000
97
3.722
1.167
418
189
105
179
74
12.677
439
6,722
2.778
2.253
1,653
326
253
326
+ 2.742
+ 49
± Ul
+ 167
+ 253
+ 63

+ 74
+ 221
P8/L3
ND
7.290 + 0
244 + 0
I. Ill + 222
703 + 185
985 +238
368 + 10
147 + 63
158 + 21
T
P8/L4 P8/L5
HD
21,871 3.742
366 + 0 S12
7.889 + 500 8,944
1.926 + 333 1.741
8.522 + 2492 4.746
2,734
-
362
213
T
+ 452
+ 195
+ 3,167
+ 333
+ 1612
+ 596
T
+ 74
+ 96
P8/L6
ND
28.258 + 12.129
1,049 + 73
9,944 + 2.167
3.370 + 0
7,209 + 418
4,426 + 1,228
T
T
T
F8/L7
342 +
14.710 +
1,000 +
18.278 +
2,926 +
14.209 +
5.703 +
392 +
3.392 +
5.513 +
79
4.774
146
6.167
0
1,478
838
94
945
1.257
        See Table A-35 for sampling protocol.
       t                   O
        Values are In ng/m , ND = not detected, T =  trace, - = not  determined.

-------
               Table  A-55.   ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED HYDROCARBONS IN AMBIENT AIR
                                     AT SITE NO. 4 IN FORDS, NJ (9/26-27/78)a
ho
NJ
-P-
Category Co«r"«n
-------
           Table A-56.  ESTIMATED LEVELS  OF VAPOR-PHASE HALOGENATED HYDROCARBONS IN
                   AMBIENT AIR AT SITE  NO.  5 IN CARLSTADT,  NJ (9/28-29/78)a
Site No. S
Category Compound
Ublqultoua chloroform
1.2-dlchloroethane
1,1, 1- 1 rlchloroe thane
carbon tetrachlorlde
trlchloroethylene
tetrachloroethylene
chlorobenzene
•t-d Ichlorobenzene
<>-d Ichlorobenzene
Stte-0peclClc trlchlorobenzene
vinyl chloride
P10/L1
5,296

22,625
2,560
14,058
2.689
422
95
211

1,225
4 l,333b
-
4 0
4 200
4 633
4 289
4 33
4 0
4 22
-

P10/L2
30,629
314
1.812
460
1.067
670
48
27
23
23
ND
P10/L3
27.889
371
10.062 4 62
1.344
23.838 4 5,467
2,080 4 589
732 4 285
89 4 22
259 4 71
19
• 68
P10/L4
25.556
657
21,062 4
2,840 4
30,800 4
7.465 4
1,762 4
287 4
891 4
89 4
247


5,687
880
3.600
2.148
99
59
287
39

P10/L5
18,556 4
-
25,437 4
2.320 4
17.883 4
24.895 4
1.223 4
235 4
306 ±
88 4
635
6,481

5,562
400
833
1.565
423
70
47
18

P10/L6
37,296
-
13,687 4 2.187
1.880 4 480
6.950 4 467
4,625 4 87
4,637 4 87
100 4 6
72 4 12
-
T
P10/L7
34.111
	
19,375 4
2.280 4
17,050 4
7,951 4
1,622 4
305 4
256 4
109 4
122


1.438
680
3.350
768
134
37
24
12

See Table A-36 for sampling protocol.

Values in ng/m , - = not detected, T = trace.

-------
a
ON
                Table A-57.   ESTIMATED LEVELS OF VAPOR-PHASE 11ALOGENATED HYDROCARBONS IN AMBIENT AIR
                                     AT SITE NO. 5 IN CARLSTADT, NJ (9/29-3/78)a
Sit. Ha. )
CiKfOTT Cf^fmml H 1/1.1 Ml/I. 2
Ubltfgultoui chloroform 72,444 47,148 t 11,778
l,l-41dilor« 71) 12)
Tlnrl chloric)* ,1,581 1,112
fll/t]
13.740 « 1,407
2.833 1 333
9,000 i 1,0)9
6,37) t 2,167
)6.<20 1 6,])2
12.402 > 972
2)2 J 17
7)7 t 214
467 * 7)
121 t 0
1,071
M1/L4
96,926
J.3S9 t )]
1«.)88 > 9,294
),87) > 708
90,196 1 16,10)
28,072 » 7,229
1)0 * 17)
2,732 > 897
1,1)4 i 412
- 360 i 17)
712
Ml/I.) Ml/16
1,617
4,472
46.23)
7.708
89,448
4). 89)
383
2,)9)
2.384
)7)
964
i 440 18,148 t 222
1 889
1 11,0)9 41,388
1 1,62) 3,12)
< 14.84) 30,862
i 10,1)1 39,430
1 21 342
i 160 1.468
> 4)1 671
t 10) 221
116
Ml/17
36,18] 1 10.778
f
101.23) t 60,941
114,9)8
17,862 < 638
37,0)6 I 380
732
830
704
)77
169
M2/I.8
54. )5)
-
3.118
792
2,690
130.886
228
386
128
8
KB
ri 2/1,9
12,961 t 4,8)2
T
1,118 1 118
189 1 0
724 t 190
2,44) < 14)
14) 1 8
74 i t
66 1 «
-
m
               o
                See Table  A-36  for  sampling protocol.

                Values  in  ng/tn  ,  -  =  not  detected,  T = trace.

-------
                         Table A-58.  SAMPLING  PROTOCOL FOR CENTRAL AND NORTHERN NEW JERSEY
to
10
Site
Paterson, NJ
(SI)
Clifton, NJ
(S2)
Passaic, NJ
(S3)
Hoboken, NJ
(S4)
Fords, NJ
(S8)
Sampling Time
Sampling Location (min)
12th St. & 4th Ave. 42
Dyer Ave. £, 39
Wheeler St.
First St. & 39
Essex St.
New County Rd . 39
U. S. Post Office
Depot
North of Tenneco 44
plant
Sampling Volume
(«,) Remarks
300 3/22/76
40°F
300 3/22/76
45°F
300 3/22/76
40°F
300 3/23/76
51°F
300 3/26/76
72°F
1231-1313 hr
300~360ffl/3 mph
1528-1607 hr
320°/2 mph
1715-1754 hr
320°/5 mph
1223-1302 hr
280VO-10 mph
1559-1643 hr
200°/0-2 mph
           See reference  A-2.

-------
                  Table A-59.  ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED.ORGANICS IN NEW JERSEY1
N>
M
OO
Chemical
methylene chloride
carbon tetrachloride
1, 2-dichloroethane
1, 1-dichloroethane
1,1,2-trichloroethane
1,1, 1,2-tetrachloroethane
1, 1, 2, 2-tetrachloroethane
pen tachloroe thane
hexachloroe thane
o-dlchlorobenzene
m-dichlorobenzene
£-dichlorobenzene

Paterson
1091b
<59
<212
<200
<167
<20
<20
<17
<17
<33
T(33)
<30

Hoboken
<454
833
<58
<160
<167
<20
<20
<17
<17
T(33)
T(33)
<30
City
Clifton
1545
T(59)
<213
<160
<167
<20
<20
<17
<17
<33
<33
<30

Fords
9286
334
<334
<285
<250
<24
<24
<17
<17
<34
<34
<34

Passalc
400
<50
<192
<145
<167
<20
<20
<17
<17
<33
T(33)
<30

Sayrevllle
14444
555
<263
<228
<217
<22
2872
<10
<10
106
157
<9
**O«« r"— .1. 1 «. A CO f ^.-~ »n««.1-f«A, n-fe-.nC-.n.m-il /«*nCn-»«._^.n A 1 \
Valuer In ng/m  , T
                                  trace,  (  )  and < Indicate limits of detection.

-------
Table A-60.   SAMPLING PROTOCOL  FOR KIN-BUC DISPOSAL SITE
M.'tooro logical Conditions
Period
6/29/76 (PI) LI
12
L3
LA
(P2) LI
L2
L3
LA
6/30/76 (P3) Ll
L2
L3
LA
Location
(Tower Marina)
(Meadow Rd.)
(N of Site)
(N of Site)
(Tower Marina)
(Meadow Rd . )
(E of Site)
(E of Site)
(Sayreville)
(Meadow Rd . )
(Meadow Rd. )
(W of Site)
Distance from
Siten
255V1.65 km
~3A5°/O.A km
25°/O.Al km
35°/0.29 km
255V1.65 km
~3A5°/0.36 km
A0°/0.18 km
35°/0.22 km
2.01 km FSR
from site
A 5 m downwind
of chemical plant
350°/O.A6 km
305°/0.3A km
Sampling
Time
1207-1359
1206-1355
1207-1359
1207-1359
1607-1737
1607-1737
1607-1737
1607-1737
1029-1229
1030-1230
]029-1229
1029-1229
Sampling
Volume"
112
13A
156
1AO
111
175
183
187
138
187
175
191
.5



.A

.A
.2
.5
.5
.9
.2
T(°F)
82
82
82
82
86
86
86
86
82
82
82
82
ZRII
69
69
69
69
57
57
57
57
76
76
76
76
Wind Dir./
Speed
255
mph
2AO
mph
2AO
mph
°/2-7
°/3-7
°/3-7
210-2550/
2-8 mph
270
mph
°/2-7
220-2A00/
0-3 mph
-
2A5
mph
70°
mph
100
2-7

95^
5-9

°/0-2
\
/2-7
+1AO"/
mph
-
1200/
mph
in
30.
30.
30.
30.
30.
30.
30.
30.
30.
30.
30.
30.
Hg
19
19
19
19
18
18
18
18
12
12
12
12
                         (contInucd)

-------
                                               Table A-60  (cont'd.)
            Period
    Location
Distance from
   Sitea
                       Hetcoroloi;ical Conditions

 Sampling  Sampling              Wind Dir./
   Time    Voltimeb   T (°F) %R1I    Speed     in Hg
                 (PA)  LI (Tower Marina)  255°/1.65 km
                       L2 (Meadow Rd.)    21 m from
                                          chemical plant

                       L3 (N of Site)     0°/0.73
U>
O
L4 (NE, then N
   of site)c
25°/0.41 km
345°/0.91 km
         7/1/76 (P5)   LI (Tower Marina)  255°/l-65 km
                       L3 (On-Site)
                       L4 (E of Site)
                   40V0.18 km
                (P6>   LI (Tower Marina)  255°/1.65 km
                       L2 (Meadow Rd.)    345°/0.36 km
                       L3 (On-Site)
                                      1457-1646  117.7
1458-1646  248

1457-1646  200.3

1457-1528  0.104
1537-1648  0.269
1006-1206  114.4
                       L2 (Meadow Rd.)    -76 m from         1006-1206  204.2
                                          chemical plant
                                      1015-1038  19.8
                   1006-1206  230
                                      1425-1625  120
                                      1425-1625  181
                                      1444-1458  19.8
88   57   18(H200°/   30.07
          5-12, 20-
          35, 10-20

88   57   190°/5-15   30.07
          mph

88   57   190°/5-20   30.07
          mph

88   57   180-»-200V   30.07
          5-35 mph

79   57   270°/5-9    30.10
          mph

79   57   230-2600/   30.10
          4-12 mph

79   57   260°/4-9    30.10
          mph

79   57   230-250"/   30.10
          4-12 mph

84   43   270°/2-5    30.12
          mph

84   43   230-2600/   30.12
          2-5 mph
84   43   230-2600/   30.12
          2-5 mph
                                                   (continued)

-------
                                               Table A-60 (cont'd.)
                                                                                      Meteorological Conditions

                                           Distance from       Sampling  Sampling              Wind Dlr./
             Period         Location           Sltea             Time     'Volume"  T(°F)  %RH     Speed    in llg


                        L4 (E of Site)     40°/0.18 km        1425-1625   208.A      84   43   230-2600/   30.12
                                                                                               2-8 mph

           Approximate magnetic bearing and distances relative to Kin-Buc (reference A-2).

           Volume in liters.
          c
           Sampler was moved to new site during sampling period.
LO

-------
Table A-61.  ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED ORGANICS IN AMBIENT AIR
                FROM KIN-BUG DISPOSAL SITE, EDISON, NJ (PERIODS 1 & 2)3
Sampling Period/Location
Chemical
methylene chloride
chloroform
carbon tetrachlorlde
vinyl chloride
vlnylldlne chloride
1, 2-dlchloroethylene
1, 1-dlchloroethane
1, 2-dichloroethane
1, 1, 1-trichloroethane
1, 1,2-trichloroethane
trlchloroethylene
tetrachloroethylene
1,1,1, 2-tetrachloroethane
1, 1,2,2- tetrachloroe thane
pen tachlcroe thane
hexachloroc* thane
chlorobenzene
cj-dlchlorobenzene
m-dlchlorobenzene
j>— di chlorobenzene
PI/LI
<1000
6389
<111
<18750
<555
<555
<470
<348
T(417)
<294
T(131)
354
<53
<53
<45
<45
170
<89
705
<80
P1/L2
<1000
T(230)
<153
<15000
<454
<454
<364
<381
NQ
<294
210
1527
<45
<45
<37
<37
112
1873
33783
<67
P1/L3
<1000
T(230)
1312
< 15000
<454
<454
<364
<381
T(417)
294
1315
T(45)
<38
<38
<32
<32
<96
<64
244
<58
P1/L4
T(1000)
T(230)
750
< 15000
<454
<454
<364
217
T(417)
294
10052
T(45)
<38
<38
<36
<36
507
77
<64
<58
P2/L1
T(3750)
1999
12687
<18750
<555
4947
<470
T(150)
T(555)
<357
4947
1187
<54
<54
<45
<45
T(135)
<90
T(90)
<81
P2/L2
T(3750)
T(230)
13687
<18750
<555
4500
<470
434
T(417)
<357
4500
T(49)
<34
<34
<28
<28
T(85)
T(57)
205
<51
P2/L3
T(3750)
T(230)
7250
<18750
<555
5263
<470
T(347)
T(417)
<357
5263
2896
<32
<32
<27
<27
T(82)
<55
<55
<49
P2/L4
T(3750)
<230
1937
<18750
<555
T(565)
<470
2173
T(417)
<357
T(178)
T(49)
<32
<32
<26
<26
1127
<53
<53
<48
                                     (cont inued)

-------
                                                Tabie A-6J  (confd.)
Sampling Period/Location
Chemical
1,2,4- trichlorobenzene
1, 3, 5- trichlorobenzene
1, 2, 5- trichlorobenzene
PI/LI
<53
<45
<53
P1/L2
<45
<37
<45
P1/L3
<38
<32
<38
P1/L4
<58
<36
<38
P2/L1
<54
<45
<54
P2/L2
<34
<28
<34
P2/L3
<32
<27
<32
P2/L4
<32
<26
<32
            See Table A-60 for sampling protocol.
                                                                                   -j

            T = trace, ( ) and < indicates limit of detection.  All  values  in ng/m .
K)

LO

U)

-------
Table A-62.  ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED ORGANICS IN AMBIENT AIR
                FROM KIN-BUG DISPOSAL SITE, EDISON, NJ (PERIODS 3 & 4)&
Sampling Period/Location
Chemical
methylene chloride
chloroform
carbon tetrachlorlde
vinyl chloride
vlnylidine chloride
1, 2-dichloroethylene
1, 1-dlchloroethane
I , 2-dichloroethane
1,1,1-trichloroe thane
1, 1,2-trichloroethane
trlchloroethylene
tetrachloroethylene
1, 1, 1, T-tetrachloroethane
1, 1, 2, 2-»:etrachloroethane
pentachloroathan3
hexachloroe thane
chlorobenzene
o-dlchlorobenzene
ra-dlchlorobenzene
£— dtchlorobenzene

P3/L1
7600
9000
T(125)
<15000
<454
<454
<476
37913
<417
3500
3737
<50
<43
<43
<36
<36
<109
<72
T(72)
<65

P3/L2
T(1000)
1944
T(125)
< 15000
<454
<454
<476
<347
<417
<294
T(178)
291
<32
<32
<27
<27
167
<53
<53
<48

P3/L3
T(1000)
12333
T(125)
< 15000
v <454
<454
<476
T(347)
19167
<294
i 6895
2847
<34
<34
<28
<28
480
341
376
<48
(continued)
P3/L4
T(1000)
3445
2000
<15000
T(454)
<454
<476
347
158
<294
10315
<49
<34
<34
<26
<26
1807
942
895
<47

P4/L2
T(1250)
5834
1875
<18750
<588
<588
<470
T(444)
T(556)
<357
394
527
<34
<34
<20
<20
T(60)
<40
T(40)
<36

P4/L3
T(1250)
8999
7625
<18750
<588
<588
<470
1130
7684
<357
5289
9173
<30
<30
<25
<25
607
150
410
<45

P4/L4
1(1250)
2778
T(153)
<18750
<555
<555
<470
<444
T(555)
<357
T(214)
1389
<40
<40
<27
<27
610
T(54)
T(54)
<49


-------
                                               Table A-62  (cont'd.)
Sampling Period/Location
Chemical
1,2,4- trichlorobenzene
1, 3, 5- trichlorobenzene
1, 2, 5-trichlorobenzene
P3/L1
<43
<36
<43
P3/L2
<32
<27
<32
P3/L3
<34
<28
<34
P3/L4
<34
<26
<34
P4/L2
<34
<20
<34
P4/L3
<30
<25
<30
P4/L4
<32
<27
<32
           a
            See Table A-60 for sampling protocol.

            Values are in ng/m , T = trace,  ( ) and < indicates  limit  of  detection.
U>
tn

-------
Table A-63.  ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED ORGANICS IN AMBIENT AIR
                FROM KIN-BUG DISPOSAL SITE, EDISON, NJ (PERIODS 5 & 6)3
Sampling Period/Location
Chemical
methylene chloride
chloroform
carbon tetrachloride
vinyl chloride
vlnylldine chloride
1, 2-dlchloroethylene
1, 1-dlchloroethane
1, 2-dichloroethane
1, 1, 1-trichloroethane
1,1,2- 1 rlchloroe thane
trlchloroethylene
tetrachloroethylene
1, 1,1,2-tetrachloroethane
1,1,2, 2- tetrachloroethane
pen tac!ilc-oe thane
hexachloro^? thane
chlorobenzene
o-dlchlorobenzene
m-dlchlorobenzene
j>~dlchlorobenzene
P5/L1
T(1000)
17222
<125
< 15000
<454
<454
<380
T(348)
T(417)
<294
T(132)
1360
<52
<52
<44
<44
T(132)
<88
T(88)
<79
P5/L2
T(1000)
11111
<125
<15000
<454
<454
<380
<348
T(417)
<294
T(132)
152
<29
<29
<25
<25
T(74)
T(49)
T(49)
<45
P5/L3
40000
19444
<125
<15000
<454
<454
<421
7575
3417
<263
18,940
25560
<29
<29
<25
<25
T(74)
1526
, 789
<45
P5/L4
100000
8334
7000
<15000
<454
<454
<421
9565
M 50000
4467
3684
34632
<34
22285
<22
<22
12791
5087
839
<39
P6/L1
3000
944
3125
<15000
<454
<454
<421
T(347)
T(417)
<294
T(132)
694
<50
<50
<42
<42
T(77)
1500
659
75
P6/L2
T(1000)
2500
625
<16667
<500
<500
<320
<276
<417
<444
T(132)
1229
<33
<33
<28
<28
T(83)
T(55)
T(55)
<50
P6/L3
260000
27200
10600
<16667
<500
<500
22700
27700
121000
<263
T(263)
394000
<315
15000
<263
<263
2656
9899
3526
474
P6/L4
42000
28334
7000
<16667
<500
<500
<400
260
75000
<312
10606
12500
<29
1389
<24
• <24
918
300
T(48)
<43
(continued)

-------
                                    Table A-63 (cont'd.)
Sampling Period/Location
Chemical
1,2, A-trichlorobenzene
1, 3, 5-trichlorobenzene
1, 2, 5-trichlorobenzene
P5/L1 P5/L2
<52 <30

-------
        Table A-64.  AMBIENT AIR SAMPLING PROTOCOL FOR INVESTIGATING  CHEMICAL DUMP/LANDFILL  IN EDISON, NJ
    Sampling                    Bearing°/distance  Sampling Time
     Period  Location (No.)                (mi)          (min)     m /cartridge
                                                         Remarks
       1     Parkland (1)
180-260/0.25
U)
CO
             Tower Marina (2)    065-909/M
             Schoolliouse Rd.
             East Brunswick,  NJ
             Parkland (1)
             Parkland (1)
             Parkland  (1)
180-260/0.25
             Tower Marina (2)     065-090/V1
180-260/0.25
       4      Tower Marina (2)     065-090/M
160-275/MK06
36
                       38
38

40
39

45
0.317      3/24/76 - 12:47 pm-l:23 pm
            65°F          35% Rll
            Clear        30,48" Hg
           Wind ^230°, 3-8 mph

0.300      3/24/76 - 4:47 pm-5:25 pm
            64°F          38% Rll
            Clear        30.42" Hg
           Wind 200-230°, 5-13 mph
           (upwind sample)

0.290      As above
0.032      (downwind samples)

0.300      3/25/76 - 11:15 am-ll:55 am
            60°F          43% Rll
           3/4 Cloud     30.22" Hg
           Wind 225°, 3-8 mph
           (upwind sample)

0.300      As above
           (downwind sample)

0.300      3/25/76 - 3:08 pm-3:53 pm
           As above
           (upwind sample)

0.300      3/25/76 - 3:05 pm-3:46 pm
           As above
           (downwind sample)
                                                    (contInued)

-------
                                             Table A-64 (cont'd.)
   Sampling
    Period  Location (No.)'
                   Bearing°/distance  Sampling Time
                              (mi)
(mln)     m /cartridge
                        Remarks
ho
U>
            Top of KB Mound
            Meadow Rd.  (5)
            (between Stauffer
            and KB)
NJ Turnpike (3)
at Mill Rd.
                                            11
            Sayreville, NJ (4)
            at St. Stanislaus
            School Rd.
                       145°/0.5
                                   140°/M). 75
                       315-325/1.25
130
130
0.060      3/2576 - 3:06 pm-3s!7 pm
0.060       64°F         38% RH
           Overcast     30.11" Hg
           Wind 265-285°, 5-10 mph

0.300      3/25/76 - 4:20 pm-5:02 pm
            63°F         45% RH
           9/10 Cloudy  30.14" Hg
           Wind 245°, 2-8 mph
           (upwind sample)

0.914      3/26/76 - 10:48 am-12:59 pm
            60°F         34% RH
            Clear       30.41" Hg
           Wind 300-320°. 0-10 mph
           Shifting to 230° at 12:45 pm
           (upfield sample)
0.958      3/26/76 - 10:49 am-12:59 pm
0.117      As above
           (downwind sample)
    See map (Fig. A-29) for location number  (reference A-4)
    Relative to dump site.

-------
                  Table A-65.  ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED ORGANICS IN AMBIENT AIR

                                             FROM KIN-BUG DISPOSAL SITE3
K3
-P-
o
Period/Location1*
Chemical
vinyl chloride
1, 1-dlchloroethane
1, 1, 1, 2-tetrachloroethane
1,1,2,2-tetrachloroethane
pen tachloroe thane
hexachloroe thane
o-dichlorobenzene
m-dlchlorobenzene
jv-dichlorobenzene
1,2,4-trichlorobenzene
1,3,5-trlchlorobenzene
1,2,3-trichlorobenzene
vlnyllulne chloride
1,1,2-trlchloroethane
PI/LI
<10714
<250
<22
<22
<17
<17
6320
<33
7000
167
1160
<22
<294
17571
P2/L2
< 10000
<228
<20
<20
<17
<17
T(33)
T(33)
<30
<20
<17
<20
<263
<217
P3/2
<10714
<267
<20
<20
<17
<17
250
143
<30
<20
<17
<20
<294
<238
P4/KB
T(11538)
<444
<22
<22
<84
<84
12433
26583
<150
<100
<84
<100
<294
11435
P4/L5
<10000
<195
<20
<20
<17
<17
<33
<33
<30
<20
<17
<20
<285
<217
P5/4
<10000
<195
<20
<20
<8
<8
58
126
<10
<20
<8
<20
<263
<217
           See Table  A-64  and  Figure A-29 for sampling protocol and locations (reference A-4).

          bValues  In  ng/m3,  T  =  trace,  (  )  and < Indicate limits of detection.

-------
                      Table A-66.   ESTIMATED LEVELS OF PURGEABLE HALOGENATED HYDROCARBONS  IN
                                           DRINKING WATER FROM NEW JERSEY3
-p-
Category
Ubiquitous












Site-Specific
Site No. 1
Compound P2/L5
1,1-dlchloroethane .
chloroform 32,075b
1,2-dlchloroethane . 96
1,1,1-trlchloroethane 67
carbon tetrachlorlde 125
trlchloroethylene 3,967
tetrachloroethylene 183
chlorobenzene 42
in-dlchlorobenzene • 9
o-dlchlorobenzene 29
bromodlchloromethane 49,317
chlorodibroraomethane 11,408
bromoform 25
trlchlorobenzene
Site No. 2
P3/L6
-
97.655
167
117
108
7.667
825
75
21
23
104,250
16,558
33
-
P4/L2
-
82,683
-
2,667
85
13.625
458
67
21
50
99.525
17,350
100
- ^
P6/L4
-
57,542
-
158
145
12,808
183
25
17
17
69,333
12.500
43
-
P6/L5
-
68,058
-
158
125
13,750
242
-
21
-
95,457
17,825
61
-
Site No. 3
P6/L6
-
28,933
125
121
575
1,267
87
-
-
-
51,971
11,017
37
-
P7/L2
-
73,308
-
100
225
12,317
45
42
13
42
77.879
8,975
25
-
P7/L3
-
98,192
-
158
358
1,533
183
38
6
48
90,967
92.592
16
-
P7/L7
-
2,825
117
125
317
7,333
200
22
8
-
1,725
5,392
1,592
-
P8/L1
-
37,633
75
157
283
757
86
T
T
-
24,358
3,150
-
-
               See Tables A-31, A-32 and A-33  for  sampling  protocol.
               Values in ng/i, - = not detected, T =  trace.

-------
            Table A-67.  ESTIMATED LEVELS  OF PURGEABLE HALOGENATED HYDROCARBONS IN
                          DRINKING WATER AT SITE NO.  4 IN FORDS, NJ3
Category
Ubiquitous












Site-Specific
Compound
1 , 1-dichloroethane
chloroform
1,2-dichloroe thane
1^1,1-trichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
chlo rob en z ene
m-dichlorobenzene
o-dichlorobenzene
bromodichlorome thane
chlorodibromome thane
bromoform
trichlorobenzcne

P8/L2 P8/L3
-
37,633b 35,217
75
157 183
283 347
757 8,625
86 250
'T 25
T 12
16
24,358 2,033
3,150 2', 4
-
-
Site No
P8/L4
-
32,758
125
87
77
9,175
192
32
8
-
40,325
4,433
16
--
. 4
P8/L5
-
5,383
200
208
122
14,650
240
35
-
-
11,925
7,708
250
-

P8/L6
142
2,750
73
208
300
9,725
215
25
11
12
642
1,067
275
-

P8/L7
105
4,200
208
258
347
15,058
275
32
15
-
2,392
6,633
1,750
-
*See Table A-34 for sampling protocol.
"""Values in ng/ S,, — = not detected, T =  trace.

-------
            Table A-68.   ESTIMATED LEVELS OF PURGEABLE HALOGENATED HYDROCARBONS IN
                       DRINKING WATER AT SITE NO. 5 IN CARLSTADT, Nja
Category
Ubiquitous












Site-Specific
Compound
1 , 1-dichloroethane
chloroform
1 , 2-dichloro ethane
1,1, 1-trichloroethane
carbon tetrachloride
trichloroethylene
tetrachloroethylene
chlorobenzene
m-dichlorobenzene
o-dichlorobenzene
bromodichlorome thane
chlorodibroinome thane
bromoform
trichlorobenzene

P10/L2
-
110,775b
172
405
183
18,017
717
32
25
32
112,225
19,083
42
-

P10/L4
-
64,933
93
64
87
6,908
167
20
7
10
83,483
13,067
29
-
Site
P10/L5
-
81,583
95
88
94
4,767
192
27
8
-
93,292
15,958
56
-
No. 5
P10/L6
-
96,825
385
143
172
12,633
307
36
T
13
13,653
22,833
50
-

P10/L7
-
64,992
-
371
197
1,372
114
29
8
-
86,708
16,525
41
-

P11/L1
78
120,458
112
586
431
3,883
1,183
40
21
47
146,150
16,267
33
-
 See Table A-35 for sampling protocol.
"Values in ng/£,  - = not detected, T = trace.

-------
                                          0
                                       0.5
1.0
                                                     MILES
Figure A-29.
Sampling locations  surrounding Kir_~Buc  Landfill
Edison, NJ.                                      '
                                244

-------
                        Table A-69.   AMBIENT AIR SAMPLING PROTOCOL FOR PLAQUEMINE, LA AREA
M
.p-
Ui
Sampling Locations
Plaquemine, LA
City Water Tower,
Bayou Rd (LI)
St. John Evangelist
Church Tower,
Church and Main St.
(L2)
LA 988 & Davis St.
(L3)
50 yd East off
LA IN (L4)
East off LA 1 (L5)
Off LA 1 (L6)
Off LA 1 on Ms.
Armalline Caillouet
Sampling Time
(min)
1363
1330
250
190
190
1095
990
Volume Sampled
U)
136
133
439
289
129
109
99
Remarks
1/31-2/1/77
44°F-49% RH
1/31-2/1/77
44°F-49%RH
2/1/77
44°F-47% RH
2/1/77
44"F-47% RH
2/1/77
44°F-36% Rll
2/1-2/2/77
44°F-36% Rll
2/1-2/2/77
43°F-36% Rll

1437-1320
0°/1-12 mph
1540-1350
0°/1-12 mph
1255-1705
70°/1-12 mph
1430-1740
70°/1-12 mph
1445-1755
70°/1-12 mph
1600-1015
90°/1-12 mph
1745-1015
90°/1-12 mph
             Property (L7)

           Plaquemine Evergreen
             Plantation (L8)

           Plaquemine Evergreen
             Plantation (L9)
275
230
191
202
2/2/77       1250-1725
57°F-55% Rll  80°/l-3 mph

2/2/77       1325-1715
57°F-61/; Rll  Variable Winds

-------
                                     Table A-69  (cont'd.)
  Sampling Locations
Sampling Time
    (min)
Volume Sampled
     U)
     Remarks
Plaquemine Evergreen
  Plantation (L10)

Plaquemine Evergreen
  Plantation (Lll)
     150
    1035
     100
     103
2/2/77       1400-1630
56°F-55% RH  90°/variable

2/2-2/3/77   1705-1020
45°F-99% RH  90°/variable
See reference A-4.

-------
Figure A-30.   Map depicting sampling locations near industrial complex
              in Iberville Parish, LA.
                               247

-------
                                      WEST BATCH TOUCH PHHI8H
                                   ~~~~~      HMOH
                                                            INDUSTRIAL
                                                             COMPLEX    U10 •
Figure A-31.   Map depicting locations  of  ambient air  sampling network
               in Iberville  Parish, LA.
                                 248

-------
            Table A-70.   CONCENTRATIONS OF VAPOR-PHASE HALOGENATED ORGANICS IN IBERVILLE PARISH, LAa
Compound
Chloroacetylene
Vinyl chloride
Chloroethane
Vinylidine chloride
Location
LI
ND
192
ND
128
L2
ND
1,230
ND
36
L3
12
30
ND
ND
L4
ND
T
ND
ND
L5
58
59
ND
ND
L6
ND
534
ND
132
L7
45
1,334
1,378
990
L8
T
64
ND
ND
L9
T
76
ND
ND
L10
ND
ND
ND
ND
Lll
ND
ND
ND
ND
Bb
ND
ND
ND
ND
          Pollutants which passed through the Tenax GC cartridge were collected on  carbon  then
5^         transferred to Tenax in the lab via thermal desorption, values are  in ng/m-*.
^o        u
          B = blank carbon cartridge.

         Source;  E. D. Pellizzari, "Identification and Analysis of Ambient Air Pollutants Using the
                 Combined Techniques of Gas Chromatography and Mass Spectrometry, EPA  Contract No.
                 68-02-2262, Quarterly Technical Progress Report No. 1, December  1,  1976 - February 28,
                 1977.

-------
            Table A-71.  CONCENTRATIONS OF VAPOR-PHASE HALOGENATED ORGANICS IN IBERVILLE PARISH,  LA
Ul
O
location!
Cftrnpeund
1.1,1 IrlcMofoclbins
1,2 dkhlorotllunt
vinyl cliloild«
tsihon It lrseMorld«
dlcMofobutinv
tetfKl.lorotthylent
1,1 ,7,7-lf liicliloioell.int
chloroform
l^-dkhlotopropin*
chlorntlhlrw
Tlnylldli" chlorldf
1,1-dlchloiotlhtm
dlchlofopropeni
1,1,2 !rkhlorotlh»ni
UlfKlilorobuHditn*
nexKhloro-1,3 buUditni
1,3-dlchloropioptnt
Irkl.loropropan*
lllrlchloropruplM llomir
pcnlKl.loraelhin)
Ml- (2-thlorohopropvll elhef
ti»«thlofotlhint
pcnlecMoiobuliditnt
thlorololuint
cMorobe»';nt
11
1100,20
1726-315
HO11
800-800
153.70
82.20
52.1
1908,122
944-172
NO
NQ
N0e
ND
580-60
ND
NO
ID'S
NO
NO
NO
66-22
ND
NO
NO
NO
12
1820,100
1219-0
NO
ND
2714.2000
977 r 900
264.191
419.0
735,37
NO
NO
ND
NO
NO
139,70
NO
NO
ND
32-30
NO
ND
NO
NO
NO
NO
13
08 '3
9-7
NQ
20-10
71.45
NO
ND
NO
1015-620
NQ
NO
NO
NO
NO
NO
NO
ND
NO
NO
NO
NO
NO
NO
NO
NO
14
1500-20
1590-45
NO
ND
ND
21,0
NO
633t10
ND
NO
NQ
ND
NO
NO
NO
ND
ND
ND
ND
ND
NO
NO
NO
NO
NO
IS
430-50
399,28
NO
NO
NO
54.3
T
950-112
209,4
NO
NO
ND
ND
36.0
ND
ND
T
NO
ND
T
NO
NO
NO
ND
NO
16
2680,0
3727.1127
NQ
T
7285>I571
489.70
NO
2433.100
1363-33
NO
NQ
T
106.4
200,18
T
18.3
NO
T
242-36
ND
T
T
NO
ND
ND
17
8760. 11CO
4709.200
NO
4628.1100
1392.178
1224.173
1573.243
6866.688
2233.136
NO
NO
478.56
261.32
1840.440
17.11
37.15
ND
24,9
13-6
13,5
363.152
T
T
ND
ND
LI
1556.0
362-4
NO
335.250
ND
159-170
ND
1080(468
T
NQ
NO
ND
ND
NO
NO
NO
NO
NO
NO
NO
NO
ND
NO
35.7
29.10
L9
524.61
304.36
NQ
667.200
54.25
27.3
14B.133
511.327
NO
NQ
NQ
NO
NO
NO
NO
NO
ND
ND
NO
ND
ND
ND
ND
NO
ND
110
416.27
146,24
NQ
277.18
ND
30.10
NO
1387.161
NO
NQ
NQ
NO
NO
NO
NO
NO
ND
NO
ND
NO
ND
NO
NO
NO
NO
111
1U.56
91.30
NQ
ND
ND
16.8
NO
1113.274
NO
NQ
NO
NO
ND
ND
NO
NO
NO
NO
NO
NO
ND
NO
NO
NO
NO
            3Values are in ng/m  with reproducibility for duplicate cartridge.

             NQ = n.i^ quantitated.  These compounds were collected and analyzed from carbon cartridges.
            £
             ND = not detected.
            Source:  E. D. Pellizzari, "Identification and Analysis of Ambient Air Pollutants Using the
                     Combined Techniques of Gas Chromatography and Mass Spectrometry", EPA Contract No.
                     68-02-2262, Quarterly Technical Progress Report No. 2, March 1, 1977 - May 31, 1977.

-------
                      Table A-72.    AMBIENT AIR SAMPLING PROTOCOL FOR GEISMAR,  LA AREAa
K>
U1
Sampling Location
Corner of highway 73 and 75
(L12)
Southeast of Plant R
(L13)
North of Plant M
(L14)-l
Northeast of Plant H and N
(L15)
Northwest of Plant M off
LA 73 (L14) -2
Southwest of Plant M off
LA 73 (L16)
Sampling Time
(min)
1398
1400
260
25
1205
135
Volume Sampled
(A)
140
140
180
142
120
91
Remarks
2/28-3/1/77
28+85% RH
2/28-3/1/77
28+85% RH
3/1/77
85% RH
3/1/77
85% RH
3/1-3/2/77
52% R1I
3/2/77
52% RH

62°F
290->-2400/9 kts
62°F
290+240V9 kts
63°F
I80°/llght
63°F
180°/Hght
65°F
120"/light
65°F
120°/light
          See  reference A-4.

-------
Figure A-32.     Sampling site and locations in Geismar, LA area
                               252

-------
              Table A-73.  ESTIMATED  LEVELS  OF VAPOR-PHASE HALOGENATED ORGANICS  IN  GEISMAR,  LA AREA
Ln
U)
Compound
1, 2-clichloroethane
carbon tetrachioride
tetrachloroethyleno
chloroform
1,1 , 2-trichloroethane
methylcne chloride
1,1, 1- t r Ich lor oc thane
1 , 2-dichloropropane
1, 1-dlchloroethanc
chlorobenzune
vlnylldine chloride
L-12
683
400
46
1571
120
1700
T
ND
NO
ND
ND
L- 1 3
ND
1133
86
3057
150
1909
250
1163
ND
ND
ND
I.-14A
10333
1433
43
3000
5450
727
200
ND
235
93
T
L-lr>
7844
300
86
11742
9611
1714
200
121
75
93
ND
L-K1
232
183
11
857
ND
700
75
ND
MD
T
ND
L-1411
4689
4667
100
9943
6900
545
175
71
550
143
200
L- 1 6
1555
10100
36
999
ND
772
400
39
133
171
ND
L-K2
100
300
7
943
ND
442
ND
3999
Ml)
900
ND
L-S
800
286
32
10355
320
2333
80
ND
ND
ND
ND
L-B
1444
2633
100
1257
ND
454
675
36
167
ND
ND
'Values arc In ng/m  .
          ND
      not detected.

-------
                      Table A-74-  AMBIENT AIR  SAMPLING  PROTOCOL FOR BATON ROUGE, LA AREA
N3
l_n
Sampling Location
Off U.S. 61 North of
Plant A
(L17)
Off unpaved, unmarked rd .
(L18)
Northwest of Plant A on
Mr. Ewell's ranch
(L19)
Northwest of Plant A on
Mr. Ewell's ranch
(L20)
Off unpaved, unmarked rd.
(L21)
Eastside of LA 61
(L22)
Northwest of Plant A on
Mr. Swell's ranch
(L20)
Off of Turning Basin Rd.
(L23)
Graveyard Area
(L24)
Sampling Time
(min)
1400
1435
235
260
30 ,;
265
195
1190
1070
Sampling Volume
140
143
156
184
195
146
129
119
107
Remarks
3/3-3/4/77
-99% RH
3/3-3/4/77
-99% RH
3/3/77
rain
3/4/77
93% RH
3/4/77
93% RH
3/8/77
49% RH
3/8/77
49% RH
3/8-3/9/77
50% RH
3/8-3/9/77
50% RH

1150-1110
120°/Ught
1135-1130
120°/light
1220-1615
120°/light
1125-1545
90-KL20°/4 mph
1207-1237
90°/4 mph
1205-1630
180°/4 mph
1235-1550
180°/4 mph
1625-1215
180° /5 mph
1640-1030
180V5 mph

-------
                                                   Table A-74  (cont'd.)
t-J
Ln
Oi
Sampling Location
Mengel Rd.
(L25)
Off LA 61
(L26)
Off Mengel Rd.
(L27)
Off LA 190
(L28)
Off Mengel Rd.
(L25)
Off LA 61
(L26)
Off Mengel Rd .
(L27)
Off LA 61
(L28)
Off Mengel Rd .
(L25)
Off LA 61
(L26)
Sampling Time
(min)
190
180
1090
1080
190
180
1090
1080
240
250
Sampling Volume
a)
124
121
109
108
124
121
109
108
162
152
Remarks
3/9/77
54% RH
3/9/77
54% RH
3/9-3/10/77
54% RH
3/9-3/10/77
54% RH
3/9/77
54% RH
3/9/77
54% RH
3/9-3/10/77
78% RH
3/9-3/10/77
78% RH
3/10/77
54% RH
3/10/77
54% RH

1330-1640
180° /7 mph
1400-1700
100°/7 mph
1650-1100
180°/8-9 mph
1715-1115
180°/8-9 mph
1330-1650
100°/7 mph
1400-1700
100 °/ 7 mph
1650-1100
180°/8-9 mph
1715-1115
180°/8-9 mph
1105-1505
180°/7 mph
1140-1550
180°/7 mph

-------
                                       Table A-74  (cont'd.)
Sampling Location
Choctow Rd. and Pholox St.
(L29)
LA 1 and LA 190
(L30)
Sampling Time
(min)
235
960
Sampling Volume
(£)
173
96
Remarks
3/10/77 1215-1610
54% RH 180°/7 mph
3/10-3/11/77 1700-0900
75% RH 100° /6 mph
See reference A-4.

-------
                      ^4     \   "« ««*
                      "I        \
Figure A-33.  Sampling site and location  for  Baton  Rouge,  LA area.
                                257

-------
                                                         SCOTLANDVILLE
Figure A-34.   Sampling site and  locations in  Baton Scuge, LA.
                              258

-------
        Table A-75.  VAPOR-PHASE  HALOGENATED  AND OTHER ORGANICS  ESTIMATED IN  AMBIENT AIR OF
                                    BATON  ROUGE, LA AND VICINITY
Clu-mlcal
1.1. l-lrltliloroetlian*
t ,2-dicliloroethane
c.trton I tt rncltlor Ide
t L't r Jc hi o rout hv Knu
ch lornforro
tl Icltl ornbulane
1 ,?-rO|>rppnne
fit lurfu-t It.ino
vlnyltiU-nc cltlorlda
1 , l-illcltlorouthanr
1 . 1 . -- t r Ichloroc thane
lu'xnchloro- 1 . 3- bul. id 1 one
L It I nrup r?ne
Itfnzi'ne
at clone
nwMhylune chloride
F>- c h 1 o r o s t y r cne
die 1> lot ,.|)Cn/L-iic 1 bonier (a)
clt 1 or oprtne dlmer
r Iilnrcn7£i)e
1,1,2. 2-lct rjchlorottliane

1.17
178
117
874
a;
6,710
191
NO
HI)
II D
ND
NO
t:n
ND
11.050
1.035
2,600
ND
NU
II D
NO
ND

118
ND
712
452
34
6.'J68
ND
ND
ND
ND
ND
ND
ND
ND
2,678
1,482
2,160
Nil
HO
NO
Nil
ND

L19
ND
458
289
32
1.290
NO
ND
ND
ND
ND
ND
ND
ND
2,53$
176
280
ND
ND
ND
ND
NU

L20A
NO
585
ND
ND
181
NU
ND
ND
ND
ND
ND
• ND
ND
80
729
ND
ND
ND
ND
ND
ND

L21
178
78
74
60
4,775
ND
ND
ND
ND
ND
ND
(ID
X
1,220
682
1.999
X
ND
H
ND
ND

I.J2
ND
NO
ND
11
387
III)
ND
ND
NO
NU
ND
ND
' ND
8,099
1.521
160
ND
NO
ND
no
ND

L20B
HI)
887
111
44
542
NU
ND
ND
ND
68
ND
ND
ND
9.217
1,835
280
ND
NO
ND
ND
ND

1.2 J
200
731
592
5)
1.484
ND
30
ND
HI)
ND
ND
ND
ND
2.132
2.941
640
ND
X
ND
ND
ND
La
L24
178
712
531
41
1.097
ND
ND
NU
tin
ND
80
ND
ND
1.456
3.294
440
ND
ND
ND
MD
ND
cations
L25A
222
10.141
111
31
560
ND
NO
ND
ND
90
ND
ND
ND
676
1.447
240
ND
ND
ND
ND
ND

L26A
ND
751
ill
64
368
ND
ND
ND
ND
HO
54
ND
ND
650
988
160
ND
ND
ND
ND
T

L27
78 + 24
122 + 0
148 + 0
20 + 0
568 + 11
ND
ND
ND
ND
ND
ND
ND
ND
511
68 + 21
120 + 76
NU
ND
ND
ND
ND

1.28
ND
1.229
429
164
819
ND
ND
ND
ND
ND
NO
ND
ND
2,665
729
200
ND
ND
ND
ND
ND

L25B
ND
2,000
161
11
187
11
ND
ND
ND
14
NO
NO
ND
1.248
188
280
ND
ND
ND
ND
ND

L26B
ND
1,522
119
47
464
ND
NO
ND
ND
64
ND
21
ND
1.796
421
120
ND
ND
ND
ND
ND

L29
200
ND
74
17
258
ND
ND
ND
ND
NU
ND
NO
ND
271
129
160
NU
ND
ND
10
ND

ua
ND
5,024
1,017
250
2.129
ND
ND
ND
ND
211
511
117
ND
1.040
1.765
680
ND
ND
ND
ND
ND

L30
167
102
192
18
477
ND
ND
NO
ND
ND
ND
NU
ND
1,126
129
160
ND
X
ND
NU
71
 Downwind of several petroleum facilities.

Source:  E. D. Pellizzari, "Identification and Analysis of Ambient Air Pollutants Using the Combined
         Techniques of Gas Chromatography and Mass Spectrometry", EPA Contract No. 68-02-2262,
         Quarterly Technical Progress Report No. 3, June 1 - August 31, 1977.

-------
Table A-76.   MINIMUM TOTAL HALOGENATED HYDROCARBON VAPOR IN
               AMBIENT AIR OF BATON ROUGE, LA
Location
LI 7
L18
L19
L20A
L21
L22
L20B
L23
L24
Source: E.
, 3
ng/m
10,976
10,326
2,349
762
7,164
558
2,132
3,930
3,083
D. Pellizzari, "
Location
L25A
L26A
L27
L28
L25B
L26B
L29
LE
L30
Identification and Analysis
ng/ni
11,797
1,925
1,456
6,517
9,407
2,559
709
10,003
1,387
">f Ambient Air
     Pollutants Using the Combined Techniques of Gas Chromatography
     and Mass Spectrometry",  EPA Contract No. 68-02-2262,
     Quarterly Technical Progress Report No.  3, June 1 - August 31,
     1977.
                             260

-------
              'Table A-7?.  AMBIENT AIR SAMPLING PROTOCOL FOR VAPOR-PHASE ORGANICS

                                       IN BATON ROUGE, LA3
Sampling Site Code
3069
3069
3069
3069
3069
BA-1
BA-2
BA-3
BA-4
Bb
Date
5/12-14/77
5/14-16/77
5/16-18/77
5/18-20/77
-
Period3
1935-1430 hrs
1515-1530 hrs
1535-1400 hrs
1400-0900 hrs
-
Volume Sampled
(I)
98.7
116.6
115.4
104.5
-
Ambient Temp. (°C)
26.0 -t- 28.2
29.3 -*• 28.2
28.5 -*• 27.6
28.7 -* 24.5
-
-^ 27.6
+ 24.7
•*• 28.4
+ 25.5

 Uuplicate samples were taken  in  all  cases,  see  reference A-5.

b
 Four blanks were Included.

-------
                   Table A-78.  ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED ORGANICS IN AMBIENT AIR
                                                 FROM BATON ROUGE, LA3
K)
Chemical
methylene chloride
chloroform
carbon tetrachlorlde
vinyl chloride
1,2-dichloroethylene
1,1-dichloroe thane
1,2-dichloroethane
1,1,1-trichloroe thane
1,1,2-trichloroethane
trichloroethylene
tetrachloroethylene
1,1,1- 2-tetrachloroethane
1,1,2,2-tetrachloroethane
pentachlt, roethane
hexathloro3 thane
chlorobenzene
o-dichlorobenzene
m-dichlorobenzene
ji-dlchlorobenzene


BA-1
1229 4 229
1444 + 277
187 4 62
<15000
<454
<380
<348
500 4; 83
<294
T(132)
T(59)
<51
<51
<42
<42
T(153)
T(84)
T(102)
<76


BA-2
1449 + 337
1700 4 233
T(142)
<16670
<526 '
<444
<424
2250 4 1750
<334
T(172)
; T(60)
<52
<52
<42
<42
T(128)
T(85)
T(85)
<77
(continued)
Sample Codeb
BA-3
1900 4 900
1417 4 750
T(125)
<15000
<454
<380
<348
T(416)
<294
T(132)
T(60)
<52
<52
<42
<42
<130
T(87)
T(87)
<78


BA-4
1000
1389
T(125)
<15000
<454
<380
<348
T(416)
<294
<132
<67
<58
<58
<48
<48
<142
<95
<95
<85


B
<5
<3
<2
<15
<10
<8
<8
T(5)
<5
<5
<7
<6
<6
<5
<5
<15
<10
<10
<9


-------
CTv
(-0
                                              Table A-78  (cont'd.)
Sample Code
Chemical BA-1
1,2,4-trichlorobenzene <51
1,3,5-trichlorobenzene <42
1,2,3-trlchlorobenzene <51
vinylidlne chloride <454
BA-2
<52
<42
<52
<526
BA-3
<52
<42
<52
<454
BA-4
<58
<48
<58
<454
B
<6
<5
<6
<10
         a
          See Table A-78 for sampling protocol.
         bValues In ng/m3, T - trace,  ( ) and < indicate limits of detection.   Duplicate analyses.

-------
Table A-79-  AMBIENT AIR SAMPLING PROTOCOL FOR HOUSTON,  TX AND VICINITY
Site
Houston, TX
Houston, TX
Houston, TX
Pasadena, TX
Pasadena, TX
Pasadena, TX
Deer Park, TX
Deer Park, TX
Deer Park, TX
Deer Park, TX
Deer Park, TX
Sampling Location
Milby Park (HL1)
Off Goodyear Rd. ,
on unpaved St. (HL2)
Steelman Ave. & El
Buey Way (HL3)
Between Industrial Site
and Ship Channel (HL3)
Tenneco Property
(PL2)
Tenneco Property
(PL3)
Shell Property
(DSL1)
Shell Property
(DFL2)
Diamond Shamrock
Property (DDL1)
Off Tidal Road
(DILI)
Off Tidal Road
(DTL2)
Sampling Time Volume Sampled
(min) (£) Remarks
1670-1750
1510-1515
1620-1750
1430-1600
1430-1600
1430-1600
1100-1200
1100-1200
1455-1555
1020-1035
1115-1215
188
37
229
185
237
191
122
136
137
113
147
7/27/76
60% RH
7/27/76
60% RH
7/27/76
60% RH
7/28/76
65% RH
7/28/76
65% RH
7/28/76
65% RH
7/29/76
66% RH
7/29/76
66% RH
7/29/76
54% RH
7/30/76
50% RH
7/30/76
607. RH
93°F
160°/3 mph
93°F
160°/3 mph
93°F
160°/3 mph
89°F
160V5-10 mph
89°F
160°/5-10 mph
89°F
160°/5-10 mph
87°F
180°/4-9 mph
87°F
180°/4-9 mph
94°F
130°/4-7 mph
90°F
210°/6 mph
90°F
20O°/6-8 mph

-------
Table A-79 (cont'd.)
Site
Deer Park, TX
Deer Park, TX
Freeport, TX
Freeport, TX
Freeport, TX
La Porte, TX
La Porte, TX
La Porte, TX
Sampling Time Volume Sampled
Sampling Location (min) (i) Remarks
Off Tidal Road 1455-1555
(DTL3)
Off Tidal Road 1115-1215
(DTL4)
On Dow Chem. Property 1342-1543
(FL1)
On Dow Chem. Property 1348-1555
(FL2)
On Dow Chem. Property 1425-1508
(FL3)
On E. I. DuPont 1645-1833
de Nemours & Co.
Property (LL1)
On E. I. DuPont 1641-1824
de Nemours & Co.
Property (LL2)
On E. I. DuPont 1114-1252
de Nemours & Co.
Property (LL3)
162 7/29/76
66% RH
165 7/30/76
60% RH
116 8/9/76
65% RH
85 8/9/76
65% RH
79 8/9/76
65% RH
110 8/12/76
62% RH
82 8/12/76
62% RH
87 8/13/76
53% RH
87°F
180°/A-9 mph
90°F
200° /6-8 mph
90°F
145°/5-10 mph
90°F
145°/5-10 mph
90°F
145°/5-10 mph
90°F
130-150°/2-6 mph
90°F
130-150°/2-6 mph
92°F
240°/0-,4 mph

-------
Table A-80.  AMBIENT AIR LEVELS OF VAPOR-PHASE HALOGENATED HYDROCARBONS IN HOUSTON,  PASADENA,
                         DEER PARK, FREEPORT AND LA PORTE, TX AREAS
Cowpound
2-ehloro-l, 3-butadlene
(chloroprene)
dlchloropropene isomer
(tent.)
chloroform
vlnylldlne chloride
1, 1-dlchloroethane
1,2-dlchloroe thane
dibromoethane
1,1,1-trlchloroe thane
carbon tetrachlorlde
dlchloropropane Isomer
trlchloroethylene
dlchlorobutane Isomer
dlchlorobutene Isomer
1, ! , 2-trlchloroethane
tetrachloroethylene
dlchlorobutane Isomer
dlchloropropene Isomer(s)




1,1,1, 2- tetrachloroe thane
bls-(2-chlorolsopropy l)-
ether
hexachloro-l,3-butadltne
1 , 2-d tbromopropane
1,1,2, 2- let rachloroe thane
1,2, 3-trtchloropropane
pen tachloroe thane
jerchloroethane

IIU
4.0003


11,539
-
-
T
-
522
238
-
75
-
262
-
29
52
-




-
_

-
-
-
-
-
-

l!U
266


-
-
-
-
-
-
114
-
-
700
-
-
T
-
-




-
_

-
-
-
-
-
-

I1L3



11,538
-
-
-
-
900
T
-
39
-
-
-
21
-
-




-
_

-
-
-
-
-
-

PL1



T
-
-
-
158
-
T
-
76
-
-
-
20
-
-




-
_

-
-
-
-
-
-

TL2



T
-
_
158
-
T
146
-
5,071
-
-
-
18
-
-




-
_

-
-
-
-
-
-

DSL1



53,846
-
555
66,300
-
-
846
T
321
-
-
6,700
-
-
180
90
90


-
_

-
-
-
-
-
-

DSL2



6,420
-
-
-
-
144
T
. -
-
-
-
-
T
-
-




-
_

-
-
-
-
-
-

DDU



7,692
-
-
6,722
-
-
T
-
2,535
-
-
-
2,019
-
-




-
_

334
-
-
-
-
-

DTL1



1,923
-
-
T
-
-
T
-
-
-
-
-
75
-
T.T




-
_

-
-
-
-
-
-

DTL2



8,846
-
_
4,055
-
1,000
T
2,586
-
-
T
3,334
68
-
241
1,293
72
1,293
345
-
_

2,066
-
19
-
-
-

DTLJ



T
-
_
T
-
400
276
-
-
-
-
-
-
-
-




-
_

-
-
-
-
-
-

DTt4



15,384
-
-
T
-
400
69
-
-
-
-
-
72
-
T




-
_

25
-
-
-
-
-

FL2



280
-
-
3,300
-
16.600
11,538
69
107
-
-
.. -
94
-
' -




-
27

13.3
-
-
-
-
-

FL3



T
531
-
4,500
T
15,200
T
1,478
200
-
-
3,821
1,585
-
-




21
333

8.3
T
33
298
3,984
2,903

III



8,461
-
-
778
-
3,889
T
-
-
-
-
-
17
-
-




-
—

-
-
-
-
-
- '

LL2



8,850
-
_
-
-
27.700
1.230
-
43
-
-
-
83
-
-




-
_

T
-
-
-
-
-

LL3



7,692
-
-
-
-
T
T
T
T
-
-
-
T
-
-




-
T

T
-
-
-
-
-

                                      (continued)

-------
                                                Table A-80 (cont'd.)
Chemical Glaus
tct r.ichlorobutadlcne Isomcr
pcru nclilorobu tail lone
Isomcr (s)
vinyl chloride
trlchloropropcne
Isonicr(s)
IIL1
.


-


IIL2



-


IIL3
.


-


I'l.l
„


-


Pl,2
.


-


USL1
_


-


DSL2
.


T


DDI.l
_
67

T


DTLI
.


-


DTL2
T
T
JOO
-
T T

DTL'J
.


-


DTLA
^


-


ri.2
_


-


FU3
—


-


LL1
_


-


LL2
_


-


IL3
.


-


                      ^1
     alues  are  in ng/m ;  H - Houston, P » Pasadena, D » Deer Park, F = Freeport, L - LaPorte,  see  reference A-4.
K)
CTi

-------
                  Table A-81.   ESTIMATED MINIMUM TOTAL AMBIENT AIR LEVELS  OF VAPOR-PHASE ORGANIC
                                    CHEMICAL CLASSES IN HOUSTON AND VICINITIES3
Chemical C!«s«
Itatogenatcd hydrocarbons
Oxyponatcd Compounds
HL1
' 16,737
370
IIL2
1,100
1,966
IIL3
12.518
-
ru
294
20
PL2
5. '.33
-
DSL1
128,918
134
DSI.2
6,604
60
I)DL1
19.409
6.947
nn.i
2.07B
3.714
OTL2
25.39fl
120
DTL3
716
60
DTLA
15.990
1,020
FL2
32,028
2,726
FLJ
40,026
2,596
I.LI
13,16}
4,601
LL2
37.926
9,63'.
I.LJ
7,832
l>,253
      See  reference  A-4,   Values in ng/m ,
C»

-------
           Sampling Site     Code
                                          Date
                                                          Period
Volume Sampled
     00
                                                                                      Ambient Temp.
3079
3079
3079
3079
3079
3079
HO-1
HO- 2
HO- 3
HO- 4
HO- 5
R6
195/77-197/77
202/77-204/77
204/77-206/77
206/77-208/77
208/77-210/77

                                                        1730-930 hrs
                                                        1000-900 hrs
                                                        1030-0915 hrs
                                                        0915-0945 hrs
                                                        1000-1015 hrs
                                                                    113.4
                                                                    113.1
                                                                    112.2
                                                                    120.2
                                                                    115.2C
M
0\
VO
      blanks were Included.
Computer down, flow rates were approxlmated
                   22.4 -*• 22.3 -•• 22.4
                   16.9 -*• 16.5 -* 17.5
                   17.5 -> 17.9 -* 18.3
                   18.3 + 19.2 + 28.2
                   28.3  -* 28.1 -> 28.6

-------
                 Table A-83.   ESTIMATED LEVELS OF VAPOR-PHASE HALOGENATED ORGANICS IN AMBIENT AIR
                                                 FROM HOUSTON, TX&
N>
Sample Code
Chemical
methylene chloride
chloroform
carbon tetrachlorlde
vinyl chloride
1, 2-dichloroethylene
1,1-dlchloroe thane
1, 2-dlchloroethane
1,1,1-trichloroe thane
1,1,2-trlchloroethane
trlchloroethylene
tetrachloroethylene
1,1,1,2 -tetrachloroethane
1,1,2,2-tetrachloroethane
pentachloro: thane
hexachloroethpne
chlorobenzene
o-dlchlorobenzene
m-dlchlorobenzene
jj-dlchlorobenzene

HO-1
T(714)
541 ± 166
T(92)
<12000
<334
<285
123 ± 10
367 ± 33
<250
T(100)
T(62)
<53
<53
<43
<43
<133
<88
<88
<80

HO- 2
4555 + 1555
2282 + 162
T(87)
<10,000
<3i2 ;
<258
157 ± 36
235 + 59
<227
T(100)
57 + 4
<53
<53
<43
<43
T(132)
T(88)
T(88)
<80
(continued)
HO- 3
1222 + 111
519 + 58
T(87)
<10,000
<312
<267
242 ± 0
T(470)
<227
130 + 10
T(44)
<53
<53
<43
<43
T(132)
<88
T(88)
<80

HO- 4
2642 + 1214
896 + 396
T(95)
<12000
<334
<285
242 + 16
T(334)
<250
T(100)
<150
<50
<50
<40
<40
125 + 0
T(83)
T(83)
<75

HO- 5
2250 + 750
795 + 147
T(133)
<16667
<476
<296
345 + 63
T(454)
<312
T(135)
130 ± 26
<52
<52
<43
<43
52
T(86)
T(87)
<78

BC
<5
<3
<2
<15
<10
<8
<8
<5
<5
<5
<7
<6
<6
<5
<5
<15
<10
<10
<9


-------
                                      Table A-83 (ccmt'd.)
Sample Code
Chemical
1,2, A- trlchlorobenzene
1, 3,5-trichlorobenzene
1,2,3- tr Ichlorobenzene
vlnylldine chloride
HO-1
<53

-------
                   Table A-84.   AMBIENT AIR SAMPLING PROTOCOL FOR VOLATILE ORGANICS IN HOUSTON, TXC
N>
-~J
K)
Slnpling Slt«
TOUR Air Control
Moufflon Air Pollution Control
TCK** Air Control
Hounton Air Pollution Control
T«»* Air Control
Hou*ton Air Pollution Control
Houston Air Pollution Control
Loot Ion
Aldln* (M.1I St.)
Clunton Dr.
Aldlnc (Hall It.)
Ctsvlofi it Polk
Aldlne (H«ll Rt.)
Crnrford «t Polk
Clanton Dr.
Cod*
TCI
IIC2
TC2
IIC3
TCJ
HC4
HCS
Dat*
6/22/77
7/19/77
7/20/77
10/19/77
10/20/77
10/21/77
10/21/77
Parlod Voli
0} .3-m) hr*
0(30-09)0 hr«
0(10-0910 hr*
06 1 5-09 H hr*
1207-1510 hr*
1546-I85J hn
0607-0907 hr*
IH SanpUd (I)
90. J
63.1
57.3
1IJ.4
89.1
66.8
108.*
A»b««nt Trap. (*T)
90
80
80
(8
7t
70
72
                   See reference A-6

-------
               Table A-85.   ESTIMATED LEVELS OF VAPOR-PHASE  HALOGENATED ORGANICS IN AMBIENT AIR

                                               FROM HOUSTON,  TX
Sample Code"
Chemical
•ethylene chloride
chlorofora
carbon t etrachlorlde
vinyl chloride
1, 2-dlch loroe thylene
1 , 1-dlchloroethane
1, 2-dlch loroe thane
1,1, 1-t rich loroe thane
t rich loroe thylene
let rachloroe thylene
I J 1,1,1, 2- tetrach loroe thane
w 1, 1, 2, 2- tetrach loroe thane
pent a ch loroe thane
hex achloroe thane
chlorobeniene
o-dlchlorobenzene
m-dlchlorobenzene
£-dlchlorobenrene
1,2, 4- trichlorobenzene
1,3, 5- trichlorobenzene
1.2, 3- trichlorobenzene
vlnytlileue chloride
1 , 1 ,2- tr tch loroe thane
TCI
4375 + 3125
3884 ± 2884
T(154)
<18750
<555
<471
T(444)
T(555)
<179
T<55)
<67
<67
<55
<55
<167
<110
T(110)
<99
<67
<55
<67
<555
<357
IIC1
2736 + 1014
2064 + 397
217 + 63
<18750
4525 + 1747
<471
O48
708 + 41
T(179(
69+8
<75
<75
<62
<62
<187
<125
T<127)
<112
<75
<62
<75
<555
057
IIC2
1100 ± 100
292 + 125
T(125)
< 15000
T(454)
<381
T(348)
533 + 116
T(132)
T(79)
<95
<95
<69
<79
T(283)
<159
T(159)
<143
<95
<79
<95
<454
<294
TC2
1000 + 0
400 + 25
T(125)
<15000
<454
<38l
<348
995 ± 5
158 + 26
<123
<105
<105
<8fl
<88
<263
<175
T(175)
<158
<123

-------
Figure A-35.   Sampling locations for Deer Park and Pasadena, TX sites.
                               274

-------
CO
-J
Ln
                                                                                                N

                                                                                                1
                            Figure A-36.   Sampling  locations in Freeport, XX (Dow 'A').

-------
                          SAN     JACINTO    BAY
Figure A-37.  Sampling site and locations in La Porte, TX (E. I. DuPont deNemours & Co.).

-------
References
A-l  E. D. Pellizzari.  "Improvement of Methodologies  for  the  Collection  and
    Analysis of Carcinogenic Vapors", EPA Contract No. 68-02-2764,  Annual
    Report, submitted.
A-2  E. D. Pellizzari.  "The Measurement of Carcinogenic Vapors  in Ambient
    Atmospheres", EPA-600/7-77-055, June 1977,  288 pp.
A-3  E. D. Pellizzari.  "Measurement of Carcinogenic Vapors  in Ambient
    Atmospheres", EPA-600/7-78-062, April 1978,  273 pp.
A-4  E. D. Pellizzari.  "Analysis of Organic Air Pollutants  by Gas Chroma-
    tography and Mass Spectroscopy", EPA Contract No. 68-02-2262, Final
    Report, submitted.
A-5  E. D. Pellizzari.  "Provide Information on  the Characteristics  of Ambient
    Organic Vapors in High Chemica-1 Production", EPA  Contract No. 68-02-2721,
    Final Report, in preparation.
A-6  Pellizzari, E. D.  "Quantification of Chlorinated Hydrocarbons  in Pre-
    viously Collected Air Samples", EPA P.O. No. DA-8-1938J,  Final  Report,
    submitted.
                                     277

-------
     APPENDIX B




Metabolism Summaries
      278

-------
  Table B-l.   METABOLISM SUMMARIES FOR SOME HALOGENATED ORGANICS
                   TO BE MONITORED IN THIS STUDY
Source:   R.  Huffman,  C. Latanich, T. Collins and J. Galdwell,
         "Metabolism Summaries of Selected Halogenated Organic
         Compounds in Human and Environmental Media, A
         Literature Survey".  EPA 560/6-79-008, June 1974.
                                279

-------
              BENZYL BROMIDE
                                                                         CH  OH
                                              benzyl Bromide
Benzyl  alcohol
N>
00
O
                        Baaed on findings of Bray et al.,  (A-l)
                                                                      mercapturic acid
                                                                      ethereal  sulphate
Breath
Parent compound: No data
Half-life of parent compound: No data
Metabolites: No data
Half-life of metabolite: No data
Metabolite conjugates:
mercapturic acid
ethereal sulphate
Urine
No data
No data
No data
No data
in
(24 nrs)
21
(24 hra)
Blood
No data
No data
No data
No data


Comments Ref.




rabbit, 0.2 g/kg, via stomach tube A-l
rabbit, 0.2 g/kg, via stomach tube A-l

-------
                BENZYL CHLORIDE  (CHLOROTOLUENE)
to
OO
CH,C1
rS
U
benzyl chloride !
conjugation
with
gluts thlone
glutatl lonaae
_,. 	 ' 	 i
hydrolysis
                                                                                      S-aubstltuted cyatelne,      acetylatlon
                                                                                      glyclne and glutamlc acid  	^ mercapturlc
                                                                                                                               acid
                                         Proposed  pathway for  the  formation of mercapturlc acid  Bray  et  al.(  (B-2)

                                                 Breath         Urine         Blood              Commenta
Parent compound:

Half-life of parent compound:

Metabolites:
    benzoic or phenyl-
    acetic acida (unconjugated)

Metabolite conjugates:
    mercapturlc acid
No data

No data
No data

No data
                                                                17Z
                                                                (24 hra)
                                                                49Z
                                                                (36-671)
                                                                (24 hra)

                                                                 II
No data

No data
                                                                                guinea pig,  rate and route
                                                                                unepeci tied
                                                                                                                     Ref.
                                              rabbit, 0.2 g/kg, by stomach tube     B-l
                                              rabbit, 0.2 g/kg, by stomach tube     B-l
                                                                                                                                      B-2
                                                                27Z
                                                                                rat,  rate and route  unspecified       11-2

-------
                Benzyl  chloride  (Chloroto!uene)(continued)

                                                Breath         Urine
                                                                              Blood
                                                                                                 CommenCa
                                                                                                                                    Ref.
               Metabolite conjugates!  (cont.)

                   glycine conjugate
                   (benzoic or phenylacetic)
                   glucosiduronic acid
                   (mainly phenols)
20%
(12-16)
(24 hrs)

0.4Z
(0-5)
24 hrs
rabbit, 0.2 g/kg, by stomach tube     B-l
rabbit, 0.2 g/kg, by stomach tube     B-l
oo

-------
           BROMOBENZENE
                                        Proposed!metabolic pathway (Jollou et al,,  1974,  Pharaacql.  Ill   151-169)
                     (a)
                            (c)
DO
CO
                                     Epoxide aynthetase
                                       (Hicroaomes)
                                    NADPH + 0,
                                          Rearrangement
                                        nonenaymatlc
(d)
                                                         Br
                                      Br
                                  Covalently
                                  bound to  •
                                  macromoleculea
                                                                                    Oil  H
                                                                               (h)
(a) Brooiobenzene
(b) Bronobenzene epoxlde
(c) p-Bromophenol
(d) 3,4-Dihydro-3-hydroxy-4-
   (. S-glutathionyl bromobenzene
(e) 3,4-Dihydro-3,4-dlhydroxy-
    broroobenzene
(f) 3,4-Dihydro-3-hydroxy-4-S-
    acetyl cyateinyl bromobenzene
(g) 3,4-Dihydro-3-hydroxy-4-S-
    cysteinyl bromobenzene
(h) 3,4-Dlhydroxy bromobenzene

-------
             Bromobenzene  (continued)
CO
Breath
Parent compound: 6Z
(1-2 days)
6.3Z
Half-life of parent compounds Ho data
Metabolic half-life:
9.8 rain., whole body
horaogenate
9.3 rain, , plasma
9.5 min., liver
Metabolites:
mono phenols
(uncharacteri zed)
4-bromophenol






(a)figur*- shown is percent yield
of met'Holite obtained by ex-
traction and purification of
the ether extracts of
hydrolyzed rabbit urine
3-bromophenol

Urine Blood



No data No data






2-3Z
(1-2 days)
40Z
(48 hrs)
37%
(48 hra)
18Z
(48 hra)
1.2Z (a)
(10 days)




l.OX (a)
(10 days)
Comments
rabbit, 0.5 g/kg, oral dose

rabbit, 0.5 g/kg, stomach tube

rat, 10 umol^C— broraobenzene , i.v.

rat, 10 umol *^C-broroobenzene, i .v.
rat, 10 umol "^C-bromobenzene , i.v.
rat, 10 umol *^C-bromobenzene, i.v.

rabbit,. 0.5 g/kg, oral dose

rat, dosage not stated, i .p.
injection
rat, 10.0 mmol/kg, i.p. injection

rat, 0.05 mmol/kg, i.v. injection

rabbit, 50 mg/kg, i.p. injection





rabbit, 50 mg/kg, i.p. injection

Ref.
C-l

C-2

C-6

C-6
C-6
C-6

C-l

C-7

C-6

C-6

C-5





C-5


-------
         Bromobenzene (continued)
                                          Breath
                                                         Urine
                                                                       Blood
                                                                                          Commenta
                                                                                                                              Her.
00
Ln
        Metabolites  (cont.)
             2-broniophenol
            bromopheny1di hydrodiol
             3-4-bromophenyldihydrodiol
2-3-bromophenyldihydrodiol
             broinocatechols
             (unchaiacterized)
                                            4X
                                            (48 hrs)
(48 hrs)
31
(48 hrs)

4Z
(48 hrs)

42
(48 hrs)

3X
(48 hrs)

trace
(48 hrs)

28 X
(1-2 days)

6X
(48 hrs)

4X
(48 hrs)
rat, dosage not stated, i.p.          C-7
injection

rat, 0.05 Hanoi/kg, i.v. injection     C-6

rat, 10.0 nmol/kg, i.p. injection     C-6


rat, 10.0 maol/kg, i.p. injection     C-6


rat, 0.05 mool/kg, i.v. injection     C-6
rat, dosage not stated, i.p.
injection

rat, dosage not stated, i.p.
injection

rabbit, 0.5 g/kg,  oral dose
C-7


C-7

C-l
                                                                                        rat, 10.0 nmol/kg, i.p. injection     C-6
                                                                                        rat, 0.05 mmol/kg, i.v. injection     C-6

-------
Bromobenzene (continued)
                                 Breath
                                                Urine
                                                              Blood
                                                                                 Commenta
                                                                                                                    Ref.
Metabolites (cont.)
3 , 4-bromoca techo 1
2,3-bromocatechol
Metabolite conjugates:
total o-conjugates
total conjugates
glucuronide
ethereal sulphate
CO mercapturic acid
cr\

bromophenylmercapturic acid


4Z
(48 hrs)
trace
(48 hra)

58Z
(1-2 days)
97. 9Z
40. 2Z
36. 8X
20. 9Z
25Z
(1-2 days)
70Z
(48 hrs)
48Z
(48 hra)

rat, dosage not stated, i.p.
injection
rat, dosage not stated, i.p.
injection

rabbit, 0.5 g/kg, oral dose
rabbit, 210 mg/kg, via stomach tube
rabbit, 210 mg/kg, via stomach tube
rabbit, 210 mg/kg, via stomach tube
rabbit, 210 mg/kg, via stomach tube
rabbit, 0.5 g/kg, oral dose
rat, 0.05 mmol/kg, i.v. injection
rat, 10.0 mmol/kg, i.v. injection

C-7
C-7

C-l
C-3
C-3
C-3
C-3
C-l
C-6
C-6
                                               22Z
                                                                               rabbit, 0.5 rag/kg, via stomach tube   C-4

-------
BROMOFCMH
    Ho data were available regarding bromoform metabolites in breath,  urine or blood.   The following metabolic scheme

    represents the reduction of bromoform to carbon monoxide, based on in vi tro studies (D-l).
                                                     P-450 mixed  function
                                         Br                 oxldaae
                                          I                x         v
                                    Br  - C - Br 	}	}	
                                         II                                 carbon  monoxide
                                    bromoform

-------
              3-BROMOPROPYLBENZENE
                  3-bromopropylbenzene
                                                 phenolic
                                                 intermediates
                                                 (3-broraopropyl)
                                                 phenol probably
                                                 being the major
                                                 intermediate
                                                                               ethereal sulphate
               -\ ether soluble acid
                  glucoslduronlc acid
                  mercapturlc acid
                  glyclne conjugates
N>
Co
Co
                                             Baaed on findings reported by Bray et al., (E-l)

Parent compound!
Half-life of parent compound;
Breath
Ho data
No data
Urine
No data
No data
Blood Comments Ref.
No data
No data
            'Metaboli tes«

                 total urinary metabolites
89Z
                                rabbit, 0.25 g/kg, via stomach tube   E-l

-------
         3-Bromopropylbenzene (continued)
                                          Breath
Urine
                                                                        Blood
                                                                                           Comments
                                                                                                                              Ref.
N>
CD
         Metabolite  conjugate*!

             ethereal  sulphate

             ether soluble  acid
             (primarily glucoaiduronic acidj
             alao uercapturic acid and glycine
             conjugatea)

             phenaceturic acid
             N-acetyl-S-O-phenyl
               propyl)-L-cyateine

             phenolica
             (uncharacterized)
201

69Z
unspecified
amount

unspecified
amount

unspecified
amount
rabbit, 0.25 g/kg, via stomach tube   E-l

rabbit, 0.25 g/kg, via stomach tube   E-l




rabbit, 0.25 g/kg, via stomach tube   E-l


rabbit, 0.25 g/kg, via stomach tube   E-l


rabbit, 0.25 g/kg, via stomach tube   E-l

-------
            CARBON TETRACHLORIDE


Cl


Cl
1
- C - Cl
1
Cl
dehalogenatlon

\ \ \
f S S


Cl
1
Cl - C+
1
Cl
                                         /
                                    J\
                       carbon tetrachlorlde
                                                                                       CHC1.
                                                                                       chloroform
                                                                                             - cci
                                                                                                       carbon
                                                                                                       dioxide
                                                                                       hexachloroethane
                                             Based on findings of Paul and Rubinsteins, (F-2)
ho
VJ3
O
                                          Breath
                                                       Urine
                          Blood
                                            Comments
                                                                            Ref.
           Parent compound:
33Z
(1 hr)

40Z
(1800 hrs)

85Z
(18 hrs)
                                                       19.2 ug total
                                                       (day 1)

                                                       5.9 ug total
                                                       (day 2)
human, 80 ppm '^carbon tetra-         F-3
chloride, single breath inhalation

monkey, 46 ppm ^carbon tetra-        F-4
chloride, inhalation for 344 minutes

rat,  1.0 ml ^carbon tetra-          F-2
chloride /kg, intraduodenal

sheep, 0.1 mg/kg, intra-ruminal       F-6
                                          sheep, 0.1 mg/kg,  intra-ruminal       F-6

-------
Carbon tetraclilor i de  (continued)
                                 Breath
                                                Urine
                                                               Blood
                                                                                  Commenta
                                                                                                                     Ref.
Parent compound (cont.)
                                                4.6 ug total
                                                (day 3)

                                                trace-1.3 ug
                                                (day 4-7)

                                                1.2 ug total
                                                (day 1)

                                                1.0 ug total
                                                (day 2)

                                                0.7 ug total
                                                (day 3)

                                                trace-0.7 ug
                                                (day 4-7)
                                                               trace (at end
                                                               of exposure)

                                                               0.2 mg/100 ml
                                                               blood (at end
                                                               of exposure)

                                                               0.6 rag/100 ml
                                                               blood (at end
                                                               of exposure)

                                                               0.4 rag/100 ml
                                                               blood (at end
                                                               of exposure)
                                sheep, 0.1 mg/kg, intra-ruminal       F-6
                                sheep, 0.1 mg/kg, intra-ruminal       F-6
                                sheep, 0.12 mg/kg, intra-ruminal      F-6
                                sheep, 0.12 mg/kg, intra-ruminal      F-6
                                sheep, 0.12 mg/kg, intra-ruminal      F-6
                                sheep, 0.12 mg/kg, intra-ruminal      F-6
                                rabbit,  110 ppm,  inhalation, 4 lira    F-7
                                rabbit,  225 ppm,  inhalation,  4 hra    F-7
                                rabbit,  345  ppm,  inhalation,  4 hra     F-7
                                rabbit,  600  ppm,  inhalation,  4  hra     F-7
Half-life of  parent compound:     No data
No data
               No data

-------
                 Carbon  tetrachloride  (continued)
                                                  Breath
              Urine
                                                                               Blood
                                                                                                  Comments
                                                                                                                                     Ref.
N>
VD
N>
                Metaboli tea!
                     '^C-carbon  dioxide
                    chloroform
m
(1800 hrs)

 1Z
(18 hrs)
              3.7  ug total
              (day 1)

              2.0  ug total
              (day 2)

              1.8  ug total
              (day 3)

              trace-0.8  ug
              (day 4-7)

              6.6  ug total
              (day 1)

              1.0  ug total
              (day 2)

              0.7  ug total
              (day 3)

              traee-0.7  ug
              total (day 4-7)
monkey, 46 ppra '^carbon tetrachloride,
inhalation, 344 minutes               F-4

rat, 1.0 ml ^carbon tetra-
  chloride/kg, intraduodenal          F-2

sheep, 0.1 mg/kg, intra-ruminal       F-6
                                                                                                aheep, 0.1 Tig/kg, intra-rurainal       F-6
                                                                                                sheep, 0.1 mg/kg, intra-rurainal       F-6
                                                                                                aheep, 0.1 mg/kg, intra-rurainal       F-6
sheep, 0.12 mg/kg, intra-ruminal      F-6
                                                                                                sheep, 0.12 mg/kg, intra-ruminal      F-6
                                                                                                sheep, 0.12 rag/kg, intra-ruminal      F-6
                                                                                                sheep, 0.12 mg/kg, intra-ruminal      F-6

-------
 Cdrbcm  tetrachlor-i de (continued)




	Breath	Urine	Blood	Comments	Ret.




Metabolite  conjugates:             No data        No  data        No data

-------
    o-CHLOROBENZALDEHYDE
                         CHO
           °-chlorobenzaldehyde
 Parent Compound:




 Half-life of parent compound,
Metabolites:




Metabolite conjugateej
No data




No data
Ho data




No data
 Blood




 No data




 15 seconds




 70 seconds




 15  seconds




No  data




No data
                                                                                    Ref.
'"-••*•"-'. in vi^ro blood tests  G-,



Cat»2'65«H. I. vitro blood test.    c-,




"fc.  2-65 UM> in vitro blood test.    G.,

-------
                 CHLOROBENZENE
Ln
                                Cl
                               chlorobenzene
                                                                       Cl
                                               +proteln(SH)?> -2H

                                                or + proteins,.
                                                                                  —s.
                                Cl
                      ^x
                  —y
                                                                                                 Cl
                                                                              -protein(SH)-
                                           SC1J?CH(NH2)COOH




                                        acetylatlon
                                                                                                           SCH2CII(MIlAc)COOH
                                 Cl
                                                   -H20
                                                                      Cl
                                                                                11011
                                           OH
                               p-chlorophenol
                                                                                       -211
                                                                                HOH
3,4-dihydro-3,4-dlhydroxy-
   chlorobenzene
       OH
       I


       OH





4-chlorocatechol
                                Proposed by Smith et al., 1950  (H-2)

-------
             Chlorobenzene (continued)
                                              Breath
                                                Urine
                                                                            Blood
                                                                                               Commenta
                                                                                                                                  Ref.
N>
Parent compound;

Half-life of parent compounds

Metabolites;
    ^C-acti vi ty


    total urinary metabolitea

    glucuronide

(a) expressed as percentage
    of urinary *^C-activity
    (19.61 of total 14C-
    chlorobenzene doae)

    ethereal sulphate
                 raercapturic acid
                 p-chlorophenyImercapturi c
                 acid
                                               No data
No data


19.6Z


72.2Z

25.2*

33.57Z(a)




26.61

33.88Z(a)


20.4Z

23.80X(a)
                                                28Z
                                                27Z

                                                major
                                                metaboli te
                                                (2 days)
                                                                            No data
                                                                                             rabbit,  0,5  g/kg,  oral                 H-3
                                                                                             rabbit,  0.5 g ^C-chlorobenzene,       H-5
                                                                                             orally,  twice daily for 4 days

                                                                                             rabbit,  150 mg/kg,  via stomach  tube   II-1

                                                                                             rabbit,  150 mg/kg,  via stomach  tube   H-l
                                                                                             rabbit,  0.5 g *^C~chlorobenzene,
                                                                                             orally twice daily for 4 days
rabbit, 0.5 g ^C-chlorobenzene,
orally, twice daily for 4 days

rabbit, 0.5 g/kg, oral
rabbit, 0.5 g/kg, oral

rabbit, 10 or 12 g total dose, via
stomach tube
                                      11-5
rabbit, 150 mg/kg, via stomach tube   H-l

rabbit, 0.5 g '^C-chlorobenzene,      H-5
orally, twice daily for 4 days

rabbit, 150 mg/kg, via stomach tube   H-l

                                      H-5
                                                                      H-3
                                                                      11-4

                                                                      H-2
                 catechols
                                                             27%
                                                                                rabbit, 0.5 g/kg, oral
                                                                                                                                   H-4

-------
Chlorobenzene (continued)
                                 Breath
                                                Urine
                                                               Blood
                                                                                  Commenta
                                                                                                                     Ref.
Metabolites (cont.)
catechol derivatives
(uncharacteri red)
4-chlorocatechol
(ethereal aulphate
and glucuronide conjugates)
mono phenol s
(uncharacteri zed)
p-chl or o phenol
o-chlorophenol
p-chlorophenol and
p-chl orophenol glucuronide
di phenol a
3,4-dihydro-3,4-
dihychoxy chlorobenzene


37X
major
metabolite
(2 days)
2.84X(a)
2-3X
trace
0.5X
(2 daya)
4.l7X(a)
0.57I(a)
0.03X
(2 daya)

rabbit, 0.5 g/kg, oral
rabbit, 10 or 12 g total doae,
via stomach tube
rabbit, 0.5 g "C-chlorobenzene,
orally, twice daily for 4 days
rabbit, 0.5 g/kg, oral
rabbit, 0.5 g/kg, oral
rabbit, 10 or 12 g total doae, via
stomach tube
rabbit, 0.5 g '^C-chlorobenzene ,
orally, twice daily for 4 days
rabbit, 0.5 g l^C-chlorobenzene ,
orally, twice daily for 4 daya
rabbit, 10 or 12 g total doae, via
stomach tube

H-3
H-2
H-5
H-3
11-3
H-2
H-5
H-5
H-2

-------
CHLOROFORM
                  CHC1,
              chloroform

mlcrosomes
X
f
NADPH, 0-

Cl
1
Cl-C-Oil
1
Cl

-HC1
^ 0
/

/ «u«
                                                                                       SC1
                                                                                              - 2HC1
                                                trichloromethanol
      Proposed metabolism,
      Mwisuy  et  al.,  1977
      Blochem. Biophys. Res. Commun.  79(2)S513-517.
                                                                             phosgene
                                                                    COOH
                                                  4-carboxy-thlazolldine-2-one.
                                                                         carbon
                                                                         dioxide
                                                            covalent binding
                                                            to nucleophillc
                                                            groups of tissue
                                                            macromolecules
                                Breath
                                               Urine
                            BIc d
                                                                                 Comments
                                                                                                                   Ref.
Parent compound:
17.8-66.6t
(8 hrs)
human, 4 males,  500 mg,  oral
1-3

-------
Chloroform (continued)
                                 Breath
                                                Urine
                                                               Blood
                                                                                  Comments
Ref.
Parent compound (cont.)




(a) chloroform combined with
toluene-soluble metabolites

Half- life of parent compound:
Metabolites:
carbon dioxide



25. 6-40. 41 '
(8 hrs)
10Z
161
20Z
20JI(a)
(24 hrs)
61
No data No data No data

50. 6X
(B hra)
48.51
(8 hrs)
182
(24 lira)

human, 4 females, 500 mg, oral
human, 5 rag single breath
inhalation
monkey, 60 mg/kg, oral dose
daily for 5 days
rat, 60 mg/kg, oral dose
daily for 5 days
rat, 60 mg/kg, oral
mouse, 60 ing/ kg, oral dose,
daily for 5 days


human, 4 ma lea, 500 mg, oral
human, 4 females, 500 mg, oral
monkey, 60 mg/kg, oral

1-3
1-4
1-2
1-2
1-1
1-2


1-3
1-3
1-1
                                                                                monkey,  60  mg/kg,  oral  dose,  daily     1-2
                                                                                for 5  daya
Metabolite  conjugates!
                                  No data
                                                No data
                                                               No data

-------
              Chloroform (continued)
             Metabolites  (coot.)
                                               Breath
                                                             Urine
                                                                            Blood
                                                                                               Comments
                                                                                                                                  Ref.
                 bicarbonate/carbonate
                 compounds
66t
(24 hrs)

80Z
(24 lire)

13Z
(24 hrs)
                                                                                             rat, 60 mg/kg, oral dose, daily
                                                                                             for 5 days

                                                                                             mouse, 60 mg/kg, oral
mouse, 60 mg/kg, oral
                                                                                                                                   1-1
                                                                                                                                   1-1
o
o

-------
               CHl.OKONAPIITHALENE
OJ
O
                                               Baaed on findings of Ruzo et al. 1976.  J. Agr Cliem and Food  24(3):  581-3.

                                                                 fl
                1-chloronaphthalene
            4-chloro-l-naphthol   I

Breath         Urine          Blood
                                                                                         2-chloronaphthalena
                                                                                                  Comments
                                                                     3-chloro-2-napthol
                                                                                                                                     Kef.
               Parent compound:
                    1-C1 naphthalene
                              5.1 ug/g after   pig, 300 mg dose of 1-
                                      J-2
                              10 min.
                                                                               3.4  ug/g after
                                                                               20 min.

                                                                               1.8  ug/g after
                                                                               40 min.

                                                                               0.7  ug/g after
                                                                               80 min.

                                                                               0.9  ug/g after
                                                                               120  coin.

                                                                               0.3  ug/g after
                                                                               160  rain.

                                                                               0.3  ug/g after
                                                                               200  min.

                                                                               0.1  ug/g after
                                                                               240  min.
chloronaphthalene, 7.5 kg
pig, retrocarotid administration

-------
                  Cbloronaphthalene (continued)
                                                   Breath
              Urine
                                                                                 Blood
                                                                                                    Comments
                                                                                                                                       Kef.
                  Parent compound (cont.)

                      2-Cl naphthalene
U>
O
                 Hal.f-life of parent compound;

                 Metabolites!
                     4->"U naphthol
No data
              No data
                             6.2 ug/g after
                             10 min.
3.8 ug/g after
20 min.

1.9 ug/g after
40 min.

1.0 ug/g after
80 min.

1.0 ug/g after
120 min.

0.6 ug/g after
160 min.

0.2 ug/g after
200 min.

0.2 ug/g after
240 min.

0.1 ug/g after
260 min.

No data
              400 ug/g
              (6 hrs after
              administration)
                 pig, 300 mg dose of 2-
                 chloronaphthalene, 7.5 kg pig,
                 retrocarotial administration
                                                                                                                                        J-2
                 Yorkshire pig, 300 mg of 1-C1
                 naphthalene isomer, 7.5 kg pig,
                 retrocarotid administration
J-2

-------
Chloronaphthalene  (continued)
                                 Breath
                                                Urine
                                                               Blood
                                                                                  Comments
                                                                                                                      Ref.
Metabolites (cont.)

    4-C1 naplithol
                                                               0.1 ug/g after
                                                               160 min.

                                                               0.6 ug/g after
                                                               200 rain.
                                                               0.8 ug/g after
                                                               240 min.

                                                               1.0 ug/g after
                                                               260 min.

                                                               1.3 ug/g after
                                                               300 min.
    free phenolic compounds
     3-Cl-2-naphthal
21
(4 days)

60 ug/g
(6 hra after
administration)
                                                               0.2 ug/g after
                                                               200 min.

                                                               0.5 ug/g after
                                                               240 rain.

                                                               0.8 ug/g after
                                                               260 min.

                                                               1.0 ug/g after
                                                               300 min.
                                Yorkshire pig, 300 mg of 1-C1
                                naphthalene isomer, 7.5 kg pig,
                                retrocarotid administration
                                       (J-2)
male albino rabbit, 1 g per rabbit,
by stomach tube

Yorkshire pig, 300 mg of 2-C1
naphthalene isomer, 7.5 kg pig,
retrocarotid administration
                                                                                                                      J-l
                                                                                                                      J-2

-------
             Chloronaphthalene (continued)
                                              Breath
                                                             Urine
                                                                            Blood
                                                                                               Commenta
                                                                                                                                  Ref.
             Metabolite conjugates of
                 l-chloronaphthlene!

                 ethereal aulfate
                 mercapturic  acids


                 gIncuronic acid
                                                             10.U
                                                             (4 days)
13.1Z
(4 days)

53. n
(4 dayaj
                                aisle albino rabbits, 1 g/rabbit,      j-1
                                by stomach tube. The rabbits weighed
                                approximately 2 kg.  Expressed as
                                percentage of original dose
oo
o

-------
u>
o
Ln
           CKLORONITROBENEENE
                                            Cl
                                  HO

                                 4-chloro-3-nitrophenol

                                       NO,
HO
                                  3-chloro-A-nitrophenol
 3-amino-4-chlorophenol

       2
         Cl



   4-amino-3-chlorophenol
                                                                                      Proposed metabolism of o-chloronitrobenzene.
                                                                                      Bray et al.. 1956 (K-l)
                                 \
                                 3-chloro-2-nltrophenol        2-amlno-3-chlorophenol
                                                                   NIL
                                            Cl
                                            Oil
                                                                       Cl

                                                                       OH
                                 2-chloro-3-nitrophenol       3-araino-2-chlorophenol

-------
               CHLORONITROBENZENE
                                                  Nil.
U)
o
                                                  Cl
                                            pTchloroanlline
                              Cl
                     p-chloronltrobenzene
                                                                               OH
    Cl
2-amlno-5-chlorophenol
                                                                                 Proposed metabolism of  p-chloronltrobenzene,
                                                                                 Bray et al.,  1956 (K-l)
                                        '   2-chloro-5-nltrophenol

-------
       CIILORONITROBENZENE
OJ
o
                                    2-chloro-4-ni trophenol
 -amino-2-chloropheno1
                  m-chloronitrobenzene
                                                                                 Proposed metabolism of n-chloronltrobenzene,
                                                                                 Bray et al.,  1956 (K-l)
                                       m-chloroanlllne
2-amlno-4-chlorophenol

-------
               Chloronitrobenzene (continued)
                                                Breath
                                                               Urine
                                                                              Blood
                                                                                                Comments
                                                                                                                                   Ref.
o
Co
               Parent compounds                  No data

               Half-life of parent compounds      No data

               Metabolites of
                   o-chloronitro-
                   benzene isomerj

                  free chloroaniline


                  free phenolics
              Metabolites  of
                 m-chloronitrobenzene
                  isomer:

                 free  chloroaniline
                  free  phenol!en
              Metabolites of
                  p-chloronitrobenzene
                  isoroer:

                 fr»e chloroaniline
                 free ohenolics
Not detected   No data

Ho data        No data
                                                               trace  amounts
                                                               HZ
trace amounts
                                                              trace amounts
                                rabbit, 0.1 g/kg. Expressed as        K-l
                                percent of dose.

                                rabbit, 0.1 g/kg. Expressed aa        K-l
                                percent of dose.
rabbit, 0.2 g/kg. Expressed as        K-l
percent of dose.

rabbit, 0.2 g/kg. Expressed as        K-l
percent of dose.
                                rabbit,  0.2 g/kg.  Expressed as        K-l
                                percent  of dose.

                                rabbit,  0.2 g/kg.  Expressed as        K-l
                                percent  of dose.

-------
              Chloronitrobencenfl (continued)
                                               Breach
                                                              Urine
                                                                             Blood
                                                                                                Commenta
                                                                                                                                   Ref .
CO
O
              Metabolite conjugates of
                  o-chloroni trobenzene
                  iaomert

                 ether glucuronide
                 ethereal eulphatea
                 (aminochlorophenola and
                 chloroni trophenola)

                 ni trophenylmercapturic
                 acid

              Metabolite conjugates of
                  m-chloroni trobenzene
                  iaomer!

                 ether glucuronide
                 ethereal sulphates
                 (aminochlorophenola and
                 chloroni trophenola)

                 ni trophenylraercapturi c
                 acid

              Metabolite conjugatea of
                  p-chloronitrobenzene
                  iaomer:

                 ether glucuronide
                 ethereal sulphate
                 (aminochlorophenols and
                 chloroni trophenola)
42Z
241
7Z
331
182
 1Z
19Z
                                                              21Z
rabbit, 0.1 g/kg. Expressed  as         K-l
percent of doae.

rabbit, 0.1 g/kg. Expressed  aa         K-l
percent of doae.
rabbit, 0.1 g/kg. Expressed aa        K-l
percent of dose.
rabbit, 0.2 g/kg. Expressed as        K-l
percent of dose.

rabbit, 0.2 g/kg. Expressed aa        K-l
percent of doae.
rabbit, 0.2 g/kg. Expressed aa        K-l
percent of doae.
rabbit, 0.2 g/kg. Expressed as        K-l
percent of dose.

rabbit, 0.2 g/kg. Expressed aa        K-l
percent of doae.

-------
Chloronitrobenzene (continued)
                                 Breath
                                                Urine
              Blood
                                                                                  Comments
                                                                    Ref.
Metabolite conjugates of
    p-chloronitrobenzene
    isomer (cont.)

   conjugated chloroaniline
   ni trophenylraercapturic
   acid (colorimetic
   method)

   ni trophenylmercapturic
   acid (modified
   Stekol method)
7X
rabbit, 0.2 g/kg. Expreased as        K-l
percent of doae.

rabbit, 0.2 g/kg. Expreased as        K-I
percent of dose.
                               rabbit,  0.2 g/kg.  Expressed as        K-l
                               percent  of doae.

-------
CIILOHOPRENE
                       Cl
                                    hepatic  mixed-function oxidasea
                                                                          epoxldatlon
                  chloroprene
                                     Based on findings of Bardodej.  (L-l)

Parent compound;
Half-life of parent compound:
Metaboli tea:
Metabolite conjugates:
Breath
Ho data
No data
No data
No data
Urine
No data
No data
No data
No data
Blood Comment a Bef.
No data
No data
No data
No data

-------
                   CHLOROTOLUE.NE  -  SEE BENZYL CHLORIDE
CO
1-1
to

-------
           DICHLOROBENZENE
CO
M
U>
                            Cl
        H .  OH
1,2-dihydro~4,5-dichlo'ro-
benzene-1,2-diol
                  o-dichlorobenzene
                                         l,2-dihydro-3,4-dichloro-
                                         benzene-1,2-dlol
                                                                        3,4-d ichlorophenol
                                  2,3-dlchlorophenol
                                                                                'OH
                                                                                                  Proposed metabolism of
                                                                                                  o-d ichlorobenzene,
                                                                                                  Parke and Williams, 1955
                                                                                                  (M-3)
                                                                         3,A-dichlorocatechol

-------
DICHLOROBENZENE
        p-diclilprobenzene
                                       HO
                                11,4-dlhydro-2,5-dichloro-
                                 benkene-1,4-diol
possible direct
hydroxylation
                                  Proposed metabolism of
                                  p-dlchlorobenzene,
                                  Parke and Willla(aa. 1955 (M-3)
                                     C(                    Cl
                                                                      Cl                     Cl
                                                                  2,5-diclilorophenol    2,5-dlchloroqulnol

-------
             DICHLOROBENZENE
U)
                           m-dtchlorobenzene
                                                                                 Proposed metabolism of
                                                                                 m-dichlorobenzene,
                                                                                 Parke and Wiailama, 1955  (M-3)
                                                    l,2-dihydro-3,5-dlcljloro-
                                                    benzene-1,2-diol
I possible direct  I
Ihydroxylatlon    I
    OH
2,4-dlchlorophenol    3,5-dichloro-    3,5-dlchlorocatechol
                      phenol

-------
               Dichlorobenzeue (continued)
CO
Breath Urine Blood c.nmmanta
Parent compound: So data Ho data No
Half-life of parent compound: Ho data Ho data Ho
Metabolites of
o-iBomer :
di ch lor oca t echo 1

catechols


qui note

monophenols
Metabolites of
ra-isomer j
catechols


quinols

monophenols
Metabolites of
p- isomer:
cateMiols


quinols

monophenols

7 o»
/ . OA
/ y
*»*
4Z
AT
(M
39Z


/ «r
4*
3Z
AT
UA
2sz ;


f\V
ox
OZ
z y
OA
1ST
J JA
data
data

rabbit

rabbit
rabbit



, 0.5 g/kg, via stomach tube

, 0.5 g/kg, via stomach tube
, 0.5 g/kg, via stomach tube

rabbit, 0.5 g/kg, via stomach tube
rabbit, 0.5 g/kg, via stomach tube



rabbit,
rabbit,

rabbit,
rabbit,



rabbit,
rabbit,

rabbit,

rabbit,



0.5 g/kg, via stomach tube
0.5 g/kg, via stomach tube

0.5 g/kg, via stomach tube
0.5 g/kg, via stomach tube



0.5 g/kg, via stomach tube
0.5 g/kg, via stomach tube

0.5 g/kg, via stomach tube

0.5 g/kg, via stomach tube

Ref.

M-l

M-2
M-3

M-3
M-3



M-2
M-3

M-3
M-3



M-2
M-3

M-3

M-3

-------
              Dichlorobenxene  (continued)
OJ
              Metabolite conjugates of
                  p-iaomen
                                               Breath
                                                              Urine
                                                                             Blood
                                                                                                Comments
                                                                                                                                   Ref.
Metabolite conjugates of
o-iaomert
glucuronides

ethereal aulfatea

mercapturic acid
Metabolite conjugates of
m- is omen
glucuronides

ethereal aulfates

roercapturic acid


48Z
4BZ
21Z
21Z
5Z
5Z
31Z
- 36Z
11Z
7Z
9Z
11Z

rabbit,
rabbit,
rabbit,
rabbit,
rabbit,
rabbit,
rabbit,
rabbit,
rabbit,
rabbit,
rabbit,
rabbit,

0.
0.
0.
0.
0.
0.
0.
0.
0.
0.
0.
0.

5
5
5
5
5
5
5
5
5
5
5
5

g/kg,
g/kg,
8/k8,
g/kg,
g/kg,
g/kg,
g/kg,
g/kg,
g/kg,
g/kg,
g/kg,
g/kg,

via
via
via
vis
via
via
via
via
via
via
via
via

stomach
a tomach
stomach
stomach
stomach
stomach
stomach
stomach
stomach
stomach
stomach
stomach

tube
tube
tube
tube
tube
tube
tube
tube
tube
tube
tube
tube

M-2
M-3
M-2
M-3
M-2
M-3
M-2
M-3
M-2
M-3
M-2
M-3
                  glucuronides
                                                              37Z
rabbit, 0.5 g/kg, via stomach tube    M-2

-------
(.0
(-"
00
         Dichlorobenzene (continued)
                                          Breath
Urine
                                                                        Blood
                                                                                           Comments
                                                                                                                               Ref.
Metabolite conjugates
of p-isomer (cont.)
(glucuroni des, cont.)

ethereal sulfate

mercapturic acid



36 Z
271
27X
01
OX


rabbi t ,
rabbi t ,
rabbit,
rabbit,
rabbit,


0.
0.
0.
0.
0.


5
5
5
5
5


g/kg,
g/kg,
g/kg,
g/kg,
8/kg,


via
vi a
via
via
via


stomach
stomach
stomach
stomach
stomach


tube
tube
tube
tube
tube


M-3
M-2
M-3
M-2
M-3

-------
           1,2-DlCIILOROETHANE
                                   Proposed metabolic pathway of 1,2-dlchloroethane,
                                   Vllner, 1979 (N-l)
                 CH2CI-CH2C1
                          CH2C1-CH2OH
                1,2-dichloroethana   chloroethanol
CH C1COOH	:—»

chloroacetic acid
reaction with
glutathlone
3-carboxyaie thy leys teina
(free and conjugated)

thiodiacetic acid

S,S'-ethylene-bia-cyateine

S-(beta-hydroxyethyl)-cysteine

S-(beta-hydroxyethyl)-cyateina
   mercapturic acid
OJ
                                            Breath
                                                Urine
                 Blood
                                                                                            Commenta
           Half-life of parent  compound:

                 lite
                 CO 2
Hetaboli teal
    14
                                  Ho data
                                  12-15X
                                  of dose
                                  (3 days)
               chloroacetic acid
               (a) figure represents  the
               percentage of total radio-
               activity in urine,  rather
               than percentage of  dose.
               Total 14-C urinary  activity was
               51-73Z of dose.
                                                No data
                 Ho data
                                                6-23X(a)
                                                (3 days)
                                                    Ref.
Parent compounds
14C- 1 , 2-di cbloroe thane
10-421
of doae
(3 days)
mouse. 0.05, 0.10, 0.14 and 0.17
g/kg '''C-l^-dichloroethane,
i.p.
N-l
                                  mouse. 0.05, 0.10, 0.14 and 0.17      N-l
                                  g/kg ^C-l,2-dichloroethane,
                                  i.p.

                                  mouse. 0.05, 0.10, 0.14 and 0.17      H-l
                                  g/kg '4C-l,2-dichloroethane,
                                  i.p.

-------
1,2-DICHLOROETHANE (continued)
                                 Breath
                                                Urine
                                                               Blood
                                                                                 Comments
                                                                                                                    Ref.
Metabolites (cont.)
free S-carboxymethylcyateine
thiodi acetic acid

2-chloroethanol

Metabolite conjugates:
S-carboxymethylcysteine
Co S.S'-ethylene-bis-
^ cysteine
S- (beta-hydro xyethyj-
mercapturic acid
S-(beta-hydroxyethyI )
cysteine
i^C- activity

44-46Z(a)
(3 days)
33-34%(a)
(3 days)

O.O-O.BX(a)
(3 days)


0.5-5*(a)
(3 days)
0.7-1.0Z(a)
(3 daya)
major
metaboli te
trace amounts

51-73*
(total for
3 daya)

mouse. 0.05, 0.10, 0.14 and 0.17
g/kg ^C-l^-dichloroethane,
i.p.
mouse. 0.05, 0.10, 0.14 and 0.17
g/kg '''C-l^-dichloroethane,
i.p.
mouse. 0.05, 0.10, 0.14 and 0.17
g/kg l4c-l,2-dtchloroethane,
i.p.

mouse. 0.05, 0.10, 0.14 and 0.17
g/kg "0-1,2-dichloroethane,
i.p.
mouse. 0.05, 0.10, 0.14 and 0.17
g/kg *4Ol,2-dichloroethane,
i.p.
rat, 100 mg, stomach tube
.rat, 100 mg, stomach tube

mouse. 0.05, 0.10, 0.14 or 0.17
g/kg "C-l,2-dichtoroethane, i.p.

N-l
N-l

N-l


N-l
N-l
N-2
N-2

N-l

-------
              1 , 1 -DICHLOROE-EHYLEME
              (VINYLIDENE CHLORIDE)
                                          H:C=CCI,
Co
                                                        M'Sr>CCI  ~~~ C1C".CCI	 dCH.CO,H
                                                                        !    /   I  <»
                                                     /*C'M              •C'M/   HOH.C-CO,H
                                          (—C—CHCH.SCHrCft /—C—CHCH,SCH,Cq.H\

                                            ON.       0  I I  0  N.          I

                                               » |   '   J ^    "  ,       «/
RC—aiCH,SCH:CR'    HOiCCIICH,SCIIjrOlll

 0  NH     0         NH,
    Ac         ,           .      <0
            It)           I
                                                                   I
                                                           |HO,CCHCH,SCH.CO,H

                                                           V   0
                                                               OH
                                                                  I
                                                                  I

                                                               HSCH.CO.H   (h)


                                                                  I

                                                              (SCH.CO.H),   (J)
                                         1
                                       ico.m,

                                         I
                                        CO;
                                          '
                                                                                COiNH,),
                                                 •) 1,1- dichlorotthylene
                                                 b) chloroacetic «cid
                                                 c) 5-chlorocarbooyImethyIcysteinyl-
                                                       glutathione
                                                 d) S-carboxymethyIcyjtainylglucatluone
                                                 «) N-«cetyl-S-cy»teinyl  acetvl derivativ*
                                                 f) S-carboxymethyIcysteine
                                                 g) thiodiglycollic acid
                                                 h) thioglycotlic acid
                                                 j) dithioglycollic acid
                                      Metabolic pathway  for vinylidene  chloride in mammal*.  From Hef.  0-3

-------
1,1-DICHLOROETHYLENE
            CHLORIDE)
                                 Breath
                                                Urine
                                                               Blood
                                                                                 Comments
                                                                                                                    Ref.
Parent compound:
    unchanged 1,1-DCE
    14C-activity
    (a) total  elimination;
    primarily  urinary
   (b) primarily  thiodigly-
   colli" acid
28*
                                  20*
                                  (72  hrs)

                                  0.9X
                                  (72  lira)

                                  61
              97-99ZU)
              (72  hrs  post-
              exposure)

              92X(a)
              (72  hrs  post-
              exposure)

              96Z(a)
              (72  hrs  post-
              exposure)

              97-99X(a)
              (72  hrs)

              60-75X(a)
              (72  hrs)

              52Z(b)
              (72  hrs)

              36X(b)
              (72  hrs)
                                              rat,  50 mg (C)!, 1-DCE  per  kg,
                                              oral
rat, 50 mg (C) 1,1-DCE per kg,
oral

rat, 0.5 mg (14C)l, 1-DCE per kg,
oral
                                              mouse,  50 mg (C) 1,1-DCE per kg,
                                              oral
rat, lOppm (''•C) 1,1-DCE,
inhalation, 6 hrs
fasted rat, 200ppm
inhalation, 6 hrs
fed rat, 200 ppm
inhalation, 6 lira
                      , 1-DCE,
rat, 1 mg (  CH, 1-DCE per kg,
oral dose
rat, 50 rag
oral dose

rat, 0.5 mg
oral dose
                 , 1-DCE per kg,


                   1-DCE per kg,
rat, 50 mg (14C)1, 1-DCE per kg,
oral dose
                                                                                                                     0-3
                                                                                    0-1
                                                                                    0-1
                                                                                                                     0-3
                                      0-2
                                                                                                         1,1-DCE,      0-2
                                                                                                                      0-2
                                                                                                                      0-2
                                                                                                                      0-2
                                      0-1
                                                                                                                      0-1

-------
                    1,1 -DICHLOROETHYLBNE
                    (VIHYLIDENE CHLORIDE) (continued)
                                                     Breath
                                                                    Urine
                                                                                   Blood
                                                                                                      Comments
                                                                                                                                         Ref.
Half-life of parent compound:     No data       No data

Metabolites)
    14C02                         23Z
                                  (72 hrs)

                                   6Z
                                  (72 hra)

                                   3Z
                                                       3.5Z
                                                                                   No data
                                                                            rat, 0.5 mg (14C)1, 1-D6B per kg,
                                                                            oral dose
                                                                            rat, 50 mg ( MC)!, 1-DCB per kg,
                                                                            oral dose

                                                                            mouse, 50 mg (14Ol, 1-DCB per kg,
                                                                            oral dose

                                                                            rat, 50 mg ( 14C)1, 1-DCE per kg,
                                                                            oral dose
                                                                                                                                           0-1
                                                                                                                                          0-1
                                                                                                                                          0-3
                                                                                                                                          0-3
                    Metabolite conjugates]
                        chloroacetic acid
                                             IX
                                                                                rat, 50 mg (14C)1,1-DCE  per  kg,
                                                                                oral dose
                                                                                                                  0-3
CO
M
CO
dithioglycollic acid
                        N-acety1-8-(2-carboxy-
                        methyl) cyateine

                        N-acetyl-S-cysteinyl
                        acetyl derivative
                        tliiod i gylcolli c acid
                                                231


                                                 51


                                                 4Z


                                                50Z


                                                28 Z


                                                 3X
mouse, 50 mg ( IC) 1 , l-DCE per kg,
oral dose

rat, 50 mg (^CH.I-DCE per kg,
oral dose

rat, 50 mg (14c)l,l-DCE per kg,
oral dose
mouse, 50 mg ( 'C) 1 , 1-DCE per kg,
oral dose
rat, 50 mg ( 14C) 1 , 1-DOE per kg,
oral dose

mouse, 50 mg (14C)l,l-DCE per kg,
oral dose
                                      0-3
                                                                                                                                          0-3
                                                                                                                  0-3
                                                                                                                  0-3
                                                                                                                                          0-3
                                                                                                                  0-3

-------
1,1-DICHLOtfOETHYLENE
(VINYLIDENE CHLORIDE) (continued)  .
                                 Breath
Urine
                                                               Blood
                                                                                  Continents
                                                                                                                      Ref.
Metabolite conjugates (cent,)
(thiodi gtycolli c acid, cont.)
thioglycolli c acid

thioglycollyloxalic acid
•
urea

221
5Z
31
37
2Z
31
3.5X
rat, 50 mg (Me)!, 1-DflE per kg,
oral dose
mouse, 50 mg ( 1/fc)l , 1-DCE per kg,
oral dose
rat, 0.5 mg (14C)i,l-DCE per kg,
oral doae
mouse, 50 mg ( '^cH , 1-DCE per kg,
oral dose
rat, 50 mg (^C)!, 1-DCE per kg,
oral dose
mouse, 50 mg (l*C)l, 1-DCE per kg,
oral dose
rat, 50 mg (^Ol, 1-DCE per kg,
0-3
0-3
0-3
0-3
0-3
0-3
0-3
                                                                                oral  dose

-------
1,2-DICHLOBOETHYLENE

    Proposed metabolic pathway (by analogy to the metabolism of related compounds such aa trichloroethylene)
    CICH—CHCI
         ^   -1  7^ CISCH —CHO
b   r~"~7     r           tt             g
                  CICH,- COCI—CICH, —COOH
                          f
                       CHlOH),
                                   .
                              ltlCH*CHCll
                                I   I   |—»CI,CH-
                              (_ OH  on J
                        A proposed metabolic pathway  of 1,2-dichloroethylene.

              a)  1,2-dichloroethylene
              b)  1,2-dichloroethylene epoxide
              c)  1,2-dichloroglycol
              d)  dichloroacetaldehyde
              e)  monochloroacetyI chloride
              f)  2,2-dichloro-l,l-ethanadiol
              g)  monochloroacetic acid
    No information was available on the distribution of 1,2-dichloroethylene
    in breath, urine, or blood.  An i_n vitro study using rat liver homogenates
    reported small amounts of dichloroacetlc acid and dichloroethanol  after
    perfusion with cis or trans 1,2-DCE (P-l).

-------
                 1,2-DICHLOROPROPANE
                                              C, 0,   „
                                           H-C-C-C-H
                                              A  A   A
                                                  Breath
                                                                 Urine
                                                                                Blood
                                                                                                   Comments
                                                                                                                     Ref.
(JO
ro
ON
Parent compound:
dl chloropropane


volatile chlorinated 23. 12

0.6-1.1 mg/100
cc blood
1.5-2.9 mg/100
cc blood
1.3-1.6 mg/100
cc blood


rabbit, 1,500 ppm
day for 5 days
rabbit, 2,200 ppm
day for 5 days
dog, 1,000 ppm in
day for 5 days
rat, 1.07 mg (10.

in air
in air
air, 7
3 uCi)

, 7 hra/
, 7 hrs/
hrs/
of 1,2-

q-1
Q-l
Q-l
Q-2
    hydrocarbons, probably
    unchanged 1,2-dichloro
    propane

Half-life of parent compound:

Metabolites:
                                                                                                 dichloro-(l-l^C)propane,  single
                                                                                                 oral  dose
                     14
                       C02
                     radioactive  substances
                     pT ^.jent-producing  substance
                                                   Ho data
                                                   19.3%
No data
No data
                                                                 50.2Z
                                                present, but
                                                not identified
                                                or quantitated
                                rat, 1.07 mg (10.3 uCi ) of 1,2-       0^-2
                                dichloro-(l-''*C)propane, single
                                dose, by stomach tube

                                rat, 0.88 mg (8.5 uCi) of 1,2-        Q-2
                                dichloro-(l-'^C)propane,
                                in 0.5 ml arachis oil, single
                                oral dose

                                rat, mouse, and guinea pig; dichloro- Q-l
                                propane vapors, concentration
                                not stated
                Metabolite  conjugates!
                                  No data
                                                                 No lata
                                                               No data

-------
BE If ACHLORO 8 tJXABT EHE
                                             Based  on  findings  of Murzakaev..  (R-l)
Cl
                             \
                                       Ct
                               c ~
                           Cl
                                     \

                                        C =3 C
                                   ct
                                                Cl
                                          polychlocobutanes

                                          C.H..C1, and C.H.CL,
                                           455      4 A  6
                            iiexachlorobutadlene
                                                Urine
                                    Blood
                                                                                  Comments
Ref.
Parent compound;
Half-life of parent compound!
Hetabol i tea:
pentachlorobutane
Metabolite conjugates)
Wo 
-------
HEXACHLOROETHANE
              Cl  C!
               I   I
           C!~C —C—Cl

              C!  Cl

          hexachloroethane         I


        Ho data  were  available  on  the metabolic pathway of hexachloroethane.
                                Breath
Urine
Blood
                                                                                 Comments
                                                                                                                   Ref.
Parent compound:
hexachloroethane

Half-li!re of parent compounds No data
Metabolites,"
tri chloroethanol

50-70 ug/ml
(24 hours)

No data

1.3%
(3 days)

10-28 ug/mt
(24 hours)
0.2 ug/g
(6 hrs)
No data



sheep, 0.5 g/kg,

single oral dose
sheep (anaesthetized) 0,5 g/kg,
single oral dose


rabbit, 0.5 g of
ethane/kg body wt


'''C-hexachloro-
. , in diet

S-2
S-2


S-l

-------
            IIEXACIILOBOETHANE  (continued)
                                              Breath
                                                             Urine
                                                                            Blood
                                                                                               Comments
                                                                                                                                   Ref.
Metabolites (cont.)
trichloroacetic acid
dichloroaceti c acid
monochloroacetic acid
di ch loroethanol
oxalic acid

1.3Z
(3 daya)
0.8Z
(3 , daya)
0.71
(3 daya)
0.4X
(3 daya)
O.IX
(3 days)

rabbit, 0.5 g of l*C-hex«chloro-
ethane/kg body wt . , in diet
rabbi C, 0.5 g of ^C-hexachloro-
ethane/kg body wt., in diet
rabbit, 0.5 g of '^C-hexachloro-
ethane/kg body wt., in diet:
rabbit, 0.5 g of ^C-hexachloro-
ethane/kg body wt., in diet
rabbit, 0.5 g of ^C-hexachloro-
ethahe/kg body wt., in diet

S-l
S-l
S-l
S-l
S-l
CO
                 volatile metabolites
                 (includes COj,  CjC\^,
                 tetrachloroethylene and
                 1,1,2,2-tetrachloroethane)

                 tetrachloroethylene
                 pentad) Ioroethane
14-24X                                        rabbit, 0.5 g of 14C-hexachloro-      S-l
                                              ethane/kg body wt., in diet
              25-29 ug       0.6-1.1 ug/ml     aheep, 0.5 g/kg, single oral dose     S-2
              (24 lua)       (24 lira)

                             0.2-0.4 ug/mt     sheep, 0.5 g/kg, single oral dose     S-2
                             (6 hrs)

              20-25 ug       0.06-0.5 ug/ml    sheep, 0.5 g/kg, single oral dose     S-2
              (24 hrs)       (24 hrs)
                                                                            0 - trace
                                                                            (6 hra)
                                              sheep,  0.5 g/kg,  single oral dose     S-2
             Metabolite conjugates:
                                               No data
                                                             No data
                                                                            No data

-------
         METHYLEHE CHLORIDE
                               Based on findings  of  Kubic  and Anders,   1975.  Metabolism of dlhalomethanes
                               to carbon monoxide II.   Drug Hetab.  Dlspoa.  3(2):   104-112.
   Cl
    I
H-C-CI
    I
   H
                                             P450 mixed-function oxidaaea
                   NADPH, 0.
                                                                                         CO
                                                                                         Carbon monoxide
                          methylene chloride
U)
U)
o
                                          Breath
                                                         Urine
                                           Blood
                                                                                          Comments
                                     Ref.
         Parent compound!
             1*C methylene chloride
         Half-life for elimination
         of CftHb after methylene
         chloride exposure
              77.OZ, 92.OX
              (2 hrs)
                                           95.3%,  92.6X
                                           (8 hrs)
                                           91.50%
                                           (24  hrs)
                                                                        13  hrs.
rat, 412-930 mg/kg, i.p.  Expressed
as percentage of original dose.
These are values for individual ex-
perimental animals.

rat, 412-930 mg/kg, i.p.  Expressed
as percentage of original dose.
These are values for individual ex-
perimental animals.

rat, 412-930 mg/kg, i.p.  Expressed
as percentage of original dose.
These are values for individual ex-
perimental animals.

human, B hra exposure to 180 ppm
methylene chloride
T-l
                                                                                                  T-l
                                                                                                  T-l
                                                                                                  T-4

-------
           Methylene chloride  (continued)
                                            Breach
                                                           Urine
                                                                          Blood
                                                                                             Commenta
                                                                                                                                Ref.
           Metabolitest

               (C14)carbon dioxide
CO
U)
               carbon dioxide
                (c'4)carbon monoxide
0.44Z, 0.65Z
(2 hra)
                                             1.44Z,  1.61Z
                                             (8 hra)
                                             (24 hrs)
29Z
0.14Z, 0.14Z
(2 hra)
rat, 412-930 mg/kg, i.p.  Expressed aa T-l
percentage of original dose.  These
are values for individual experimental
animals.

rat, 412-930 mg/kg, i.p.  Expressed as T-l
percentage of original dose.  Theae
are values for individual experimental
animals.

rat, 412-930 mg/kg, i.p.  Expressed aa T-l
percentage of original dose.  These
are valuea for individual experimental
animala.
rat, 0.2 mmol/kg '^C-methylene
chloride inhalation (8 hrs), closed
rebreathing system
                                                                                                                                  T-2
rat, 412-930 mg/kg, i.p.  Expressed aa T-I
percentage of original dose.  These
are valuea for individual experimental
animala
                                              1.161,  1.691
                                              (8 hrs)
                                              2.15Z
                                              (24 hra)
                                              rat,  412-930 mg/kg,  i.p.   Expressed aa  T-l
                                              percentage  of original  dose.   These
                                              are valuea  for individual  experimental
                                              animals

                                              rat,  412-930 mg/kg,  i.p.   Expressed aa  T-l
                                              percentage  of original  dose.   These
                                              are values  for individual  experimental
                                              animala

-------
                 Methylene  chloride  (continued)
                                                 Breath
                                                               Urine
                                                                              Blood
                                                                                                 Comments
                                                                                                                                    Ref.
                Metabolites  (cont)

                     carbon monoxide
47t
oo
oo
fo
                    carbon monoxide as
                    carboxyhemoglobin (COHb)
                                                                                1.5X
                                                                               Hb saturation
                                                                               after 30 rain.
                                                                               exposure
                 rat, 0.2 mmol/kg ^C-methylene
                 chloride inhalation (8 hrs),
                 closed rebreathing ay a tern

                 human, 213 ppra methyl ene chloride
                 inhalation (60 min)
1.75Z Hb         human, 213 ppra methylene chloride
aaturation after inhalation (60 min)
60 min.
exposure

2.4Z lib
saturation 3 hrs
after exposure

10.1Z Hb         human, 986 ppn methylene chloride
aaturation 1     inhalation (2 hrs)
hr post exposure
                                                                                                                                      T-2
                                                                                    T-3
                                                                                                                                      T-3
                                                                                    T-3
                                                                               91 Hb
                                                                               aaturation
                                              human, 180 ppn,  workroom air (8 hrs)  T-4
                                                                               6X maximum       rat, 3.0 mmol/kg i.p. (after 2-2.5    T-5
                                                                               lib saturation    hrs)
                             7X maximum       rat,  440 ppm inhalation exposure
                             Hb saturation    (3 hrs)
                                                                                                                                      T-6

-------
                Methylene chloride  (continued)
                                                Breach
                                                               Urine
                                                                              Blood
                                                                                                 Comments
                                                                                                                                    Hef .
                Metabolites (cont.)

                    (^CO-unidentified
                    compound
Co
CO
CO
i[l4C)-activity
representing parent
compound and metabolites
                              0.34Z,  0.46Z
                              (2 hrs)
                                                  0.74Z, 0.86Z
                                                  (8 hrs)
                                                  1.49Z
                                                  (24 hrs)
75Z
(2 hrs)
                                                  98%
                                                  (24 hrs)
                                                                l.OZ
                                                                (24 hrs)
rat, 412-930 mg/kg i.p.  Expressed     T-l
aa percentage of original dose.
These are values for individual
experimental animals.

rat, 412-930 rag/kg i.p.  Expressed     T-l
aa percentage of original dose.
These are values for individual
experimental animals.

rat, 412-930 mg/kg i.p.  Expressed     T-l
as percentage of original dose.
These are values for individual
experimental animals.

rat, 412-930 mg/kg methylene          T-l
chloride, i.p.   Expressed aa per-
centage of orginial dose.

rat, 412-930 mg/kg methylene          T-l
chloride, i.p.   Expressed as per-
centage of orginial dose.

rat, 412-930 mg/kg methylene          T-l
chloride, i.p.   Expressed aa per-
centage of orginial dose.
                Metabolite  conjugates:
                              '.Jo data
                                            Ho data
                                                           No  data

-------
             PEHTACHLOROAHISOI.E (PGA)
                                               OCH,
                                                         demethylation
                                         pentachloroanlsole


                                             Breath         Urine
                            Blood
                                                                                              Comments
                                                                 Based on findings of
                                                                 Glickman ct al,, (U-l)
                                                                                                                                 Ref.
U>
CO
-P-
Parent Compound:



Half-life of parent compound:



Metabolites:


Metabolite conjugates:
                             Wrox. 1 ug/g   rainbow trout, 0.024 mg »4C
                             (12 hrs)         PGA/L H20 at 12°C for 12 hrs
Ho data


Ho data
Ho data


Ho data
6.3 days



No data


Ho data
                                                                                             rainbow trout, 0.024 mg ^C
                                                                                             PGA/L H20 at 12°C for 12 hrs
                                                                                                                                  U-l
                                                                                    U-l

-------
PENTACHLOHOBENZENB
                    C(

                                  ,CI
                    CJ
^-^
1 oxidation
^A
^•^ n
I C<
Cl
\
/

arene
oxide

hydroxylatlon
dechlor ination
products

                                   Metabolism of pentachlorobenzene, based  on  studies  by Kohll et al., 1976
                                   (Can. J. Blochem.. 54(3)i   203-208).
                                Breath
Urine
                                                              Blood
                                                                                 Comments
                                                                                                                    Hef.
Parent '.Compound;
Half-life of parent compound!     No data
  3Z total
 excretion
 producta
 (urine + fecea)

 No data
                No data
chinchilla doe, 0.5 mg/kg, by         V-l
atoinach tube

chinchilla doe, 0.5 mg/kg, by
subcutaneous injection

rat, rate and route of adminiatration V-2
unapeci fied

-------
Pentachlorobenr.ene (continued)
                                Breath
Urine
                                                              Blood
                                                                                 Comments
                                                                                                                   Ref.
Metabolites:

    pentachlorophenol




    tetrachlorophenol


    tetrachlorohydroquinone
    alpha-hydroxylated
    chlorothio compound

    tri- or penta- ch1orophenol
    other  phenols
    otisi  chlorohydrocarbons       9T
                                  (3 days)

                                  2U
                                  (4 days)
 91 total
 excretion
 products
 (urine + feceo)

 unapeci f ied
 amount

 unspecified
 amount

 unspecified
 amount

 0.2X
 (3 days)

 0.2%
 (4 days)

 O.IK
 (7 days)

 IX
 (3 and 4 days)
                                                (10  days)
rat, rate and route of administration V-2
unspecified
rat, rate and route of administration V-2
unapeci fied

rat, rate and route of administration V-2
unspeci fied

rat, rate and route of administration V-2
unspecified

chinchilla doe, 0,5 rag/kg, by stomach V-l
tube

chinchilla doe, 0.5 tng/kg, by stomach V-l
tube
                                                                                chinchilla doe,  0.5 mg/kg,  by
                                                                                subcutaneous  injection
                                      V-l
chinchilla doe, 0.5 mg/kg, by stomach V-l
tube
                                 chinchilla doe, 0.5 mg/kg, by
                                 subcutaneous injection
                                                                                                                      V-l
                                 chinchilla doe, 0.5 mg/kg, by stomach V-l
                                 tube
                                 chinchilla doe,  0.5 mg/kg, by
                                 stomach tube
                                      V-l

-------
CO
CO
             Pentachlorobenzene (continued)
                                             Breath
Urine
Blood
                                                                                              Commenta
                                                                                                                                 Ref.
             Metabolites (cont.)

                 (other chlorohydrocarbons,     21
                   cont.)                      (10 days)

             Metabolite conjugates!             No data
                                 chinchilla doe, 0.5 rag/kg, by
                                 subcutaneous injection
                                                        V-l
 No data
 No data

-------
               PENTACHLOROETHANE
                                                             CC1-  ! CHC1

                                                             trichloroethylene
pentac
\
cci2
CHC1, -HCL . rpl
. , , +HaO I chl
liloroethane / 1 —
-HC1
^ \
: CC1,
* 	 i r.r.i -C.
,ciio red

trichloroethanol
ox
/
nnH
CO
CO
CO
tetrachloroethylene
                                                                             y
                                                                          trichloroacetic acid
                                  Metabolism of pentachloroethane, from Yllner,  1963  (W-l)

                                               Breath          Urine           Blood
                                                         Comments
                                                                                                                                  Ref.
               Parent  compound:
          present
present
                                                                              greater  than
                                                                              1(T6  g/ml  of
                                                                              of  plasma  (3
                                                                              da  T), venous
unchanged pentachloroethane in the    W-l
urine, feces and expired air account-
ed for approx. 30Z (24 hra) of the
20 ul dose injected subcutaneously
in mice

sheep, 0.3 ml/kg single oral dose     W-2
                                                 12-5IX
                                                 (3  days)
                                                        mouse, 1.1-1.8 g/kg injected
                                                        subcutaneously
                                                                      W-3

-------
             Fentachlorotthane  (continued)
                                             Breath
                                                           Urine
                            Blood
                                                                                             Commenta
                                                                                                                                 Ref.
            Half-life of  parent  compound)     Ho  data

            Metaboli teat

                 tetrachloroethylene           present
to
CO
                 tri chloroethanol
3-9X
(3 days)

present
                 trichloroacetic acid
                                               present
              No data
              present
                             No data
                                                                            greater  than
                                                                            1
-------
 Pentachloroethane  (continued)

 	Breath	Urios 	 Bipod	Comments	  Sef.

 Metabolites  (cont.)

     tricliloruethytene             -present        present                          trichloroethylene in the urine,       W-1
                                                                                 feces  and expired air accounted
                                                                                 for  less than 5X (24 hrs) of  the
                                                                                 20 ul  dose injected subcutaneously
                                                                                 in mice.  The amount vras not
                                                                                 quantitated, but appeared to  be
                                                                                 less than the amount of
                                                                                 tetrachloroethylene eliminated.

                                  2-16X                                          mouse,  1.1-1.8  g/kg injected          W-3
                                  (3 days)                                       aubcutaneously

Metabolite conjugates:            Ho data       No data        No data

-------
             TETRACULOROBENZENB
U)
-p-

   I) 1,2,3,4
  II) 1 ,2,3,5
 III) 1 ,2,3,5
  IV) 2,3,4,5
   V) 1 ,3,4,5
  VI) 2,3,4 ,6
 VII) 2,3,5,6
VIII) 2,3,4,6
  IX) 2,3,4,5
   y.) 2,3,5,6
tetrachlorobenzene
tetraclilorobenzene
tetrachlorobenzene
tetrachlorobenzene oxide
tetrachlorobenzene oxide
tetrachlorobenzene oxide
tetrachlorobenzene oxide
tetrachlorophenol
tetrachlorophenol
tetrachlorophenol
                                                                                        Proposed mecabollsm ot tetrachlorobenzene
                                                                                        laometa, from Kolill et al., 1976 (X-l)
                                             Breath
                                                            Urine
                                                                           Blood
                                                                                              Comments
                                                                                                                                 Hef.
Parent Compound:
1,2,3,4-isomer 8X
(6
1,2,4,5-iaomer 2Z
(6
1,2,3,5-isomer 12%
(6

daya)
daya)
daya)

chinchilla
by atomach
chinchilla
by stomach
chinchi Ha
by stomach

doe rabbita,
tube
doe rabbita,
tube
doe rabbi ts ,
tube

0.5 g/kg
0.5 g/kg
0.5 g/kg

X-2
X-2
X-2

-------
Tetrachlorobenzene (continued)
Breath
Half-life of parent compounds No data
Metabolites of the
1 , 2,3,4-isomer!
2,3 ,4 ,5-tetrachloro-
plienol

other phenols
mercapturic acid
other chlorobenzenes
Metabolites of the
1,2,3,5-isomer:
2,3,4,5-tetrachloro-
phenol
2,3,5,6-tetrachloro-
phenol
i ,3,4,6-tetrachloro-
phenol
tetr.'ctilorophenols
(predominantly 2,3,4,6-
tetrac.i! orophenol
Urine Blood
No data Ho data

20%
(10 days)
43Z
(6 days)
less than 1%
(6 day,))
less than IX
(6 days)
2%
(2 days)

3Z
(10 days)
2Z
(10 days)
1.5Z
(10 days)
5Z
(6 days)
Comments


male rabbits, 300 mg/rabbit
by i.p. injection
chinchilla doe rabbits, 0.5
by stomach tube
chinchilla doe rabbits, 0.5
stomach tube
chinchilla doe rabbits, 0.5
stomach tube
chinchilla doe rabbits, 0.5
stomach tube

male rabbits, 300 mg/rabbit
by i.p. injection
male rabbits, 300 mg/rabbit
by i.p. injection
male rabbits, 300 mg/rabbit
by i.p. injection
chinchilla doe rabbits, 0.5
by stomach tube
Ref.


(4-5 kg), X-l
g/kg, X-2
g/kg, by X-2
g/kg, by X-2
g/kg, by X-2

(4-5 kg), X-l
(4-5 kg), X-l
(4-5 kg), X-l
g/kg, X-2

-------
            Tetrachlorobencene (continued)
                                            Breath
                                                           Urine
                                                                          Blood
                                                                                             Comments
                                                                                                                                 Kef.
CO
-p-
Co
Metabolites of the

    1,2,3,5-iaomer (cont.)

    other phenols


    other chlorobenzenea


Metabolites of the

    l,2,4,S-iaomen

    tetrachlorophenols


    other phenols


    other chlorobenzenea
                                              91
                                              (6 daya)
                                               10Z
                                               (6 daya)
                                                            SZ
                                                            (6 days)
21
(6 daya)

5X
(6 daya)
                                chinchilla doe rabbits, O.S g/kg,     X-2
                                by stomach tube

                                chinchilla doe rabbits, O.S g/kg,     X-2
                                by stomach tube
chinchilla doe rabbits, 0.5 g/kg      X-2
by atouach tube

chinchilla doe rabbits, O.S g/kg      X-2
by stomach tube

chinchilla doe rabbita, O.S g/kg      X-2
by stomach tube
                Metabolite  conjugateai
                                  No data
                                                No data
               No data

-------
  1,1,2,2-TETRACHLOROETHANE
                                              Adapted from the findings of Yllner,  (Y-3)
                   *                b
                   C(X :CHCl •<—
                 .    !
        lOf        CCI2:

/   \  /,    I
roa    cct, COOH HOQC
                                    CHC12CHCI2	>• (CHCI..CHOJ
                                        : CCI,
                                          COOH
                                                      c~i»i~f2 i.

                                                      '    I
                                                      CHCI2 COOH
                                                          I
                                                      CHO COOH - ^  CH2NH2COOH
                                                          I
              4) trlchloro«ehyl«na
              b) tatrachloroathane
              c) d,ichloroacetaldehyd«
              d) tjrichloroacataldehyd*
              f) dichlocoacetic acid
              g) trichloro«Chanol
              h) tcichloroacetic aci4
              i) oxalic acid
              ji glycitt
              k) glyc«ine
                                Bronl^h
                                                             Blood,
Ketafeolitai i
                                 50T
                                 (3 days)
                                                                              i.p, injection
                                                                                               8 "C-              y_3
                                                                                                l^r IE^ body »t,
mouse, 0.21-0.32 & I4C-               Y-3
tetrachloroethane per  kg  body wt,
i.p. injection

-------
             1,1,2,2-Tetrachloroethane (continued)

                                             Breath
Urine
                                                                           Blood
                                                                                              Comments
                                    Kef.
             Metabolites  (cont.)

                 dichloroacetic acid




                 trichloroethanol
Ln
                 oxalic acid
                 trichloroacetic acid
 271 of
 urinary
 activity
 (24 bra)

 10Z of
 urinary
 activity
 (24 hra)

 8.2 mg/kg
 (48 hra)

 0.8 mg/kg
 (48 hra)

 trace
 (96 hra)

 71 of urinary
 activity
 (24 hra)

 4Z of urinary
 activity
 (24 hra)

 1.7 pig/kg
 (48 hra)

 1.3 mg/kg
 (48 hrs)

 0.3 mg/kg
 (96 hra)
mouae, 0.16-0.32 g ^C-tetrachloro-   Y-3
ethane per kg body wt, i.p. injection
mouae, 0.16-0.32 g l^c-tetrachloro-
ethane per kg body wt, i.p. injection
Y-3
rat, 200 ppm, inhalation exposure
(8 hra)
                                                                                                                                  Y-4
rat, 2.78 mmol/kg body wt, (equiva-   Y-4
lent to 467 mg/kg), i.p. injection

rat, 2.78 mmol/kg body wt , (equiva-   Y-4
lent to 467 mg/kg), i.p. injection

mouae, 0.16-0.32 g Hc-tetrachloro    Y-3
ethane per kg body wt, i.p. injection


mouae, 0.16-0.32 g ""C-tetrachloro    y_3
ethane per kg body wt, i.p. injection
                                                                                            rat, 200 ppm, inhalation exposure     Y-4
                                                                                            (8 hra)

                                                                                            rat, 2.78 mmol/kg body wt, (equiva-   Y-4
                                                                                            lent to 467 mg/kg), i.p. injection

                                                                                            rat, 2.78 mmol/kg body wt, (equiva-   Y~4
                                                                                            lent to 467 mg/kg), i.p. injection

-------
co
                1,1,2,2-Tetrachloroethane (conti nued)




                                                Breath
             Urine
                                                                              Blood
                                                                                                 Comments
                                                                                                                                    Ref.
Metabolites (cont.)
urea
glyoxylic acid
chlorinated hydrocarbons

14-C activity
3?Cl-activity

21 of
urinary
activi ty
(24 hrs)
0.91 of
urinary
activity
(24 hrs)
0.5 mg/L
of urine
0.5 mg/L
of urine
28X
(3 days)
3.31
(1 hr)
of retained
radioactivity

mouse, 0.16-0.32 g l^C-tetrachloro-
ethane per kg body wt , i.p. injection
^ mouse, 0.16-0.32 g l/>C-tetrachloro-
' ethane per kg body wt, i.p. injection
dog, (dose not stated) inhalation ex-
posure (1 hr/day, up to 20 days)
rat, rabbit, and guinea pig (dose not
stated), subcutaneous injection
mouse, 0.21-0.32 g '^C-tetrachloro-
ethane per kg body wt, i.p. injection
human, 2.5 mg 38ci_tetracnioro_
ethane inhaled; 971 of the dose was
retained in the lungs

Y-3
Y-3
Y-2
Y-2
Y-3
Y-3
               Metabolite conjugates:
No data
No data
No data

-------
TETUACHLOROETHlfLENE
 Proposed metabolism of Tetrachloroethylene.  Bonae et al., (Z-2)




Tetrachloroethylene
                                                                   cci3— coci
             CC1 — COOH  *

        trlchloroacetlc       /
              acid        fazyme
                         c atalysed
                                                                          CC1.J— COR
                                                        R -  (eg.  OH,  SH, NH )
                                Breath
            Urine
                                                              Blood
                                                                                 Comment*
                                                                                                                   Ref.
Parent compound)
1 ppm
14 daya
after
exposure
97.91
(48 hra)
human, 100 ppm
day, 5 daya
rat, 1.75 uCi,
stomach tube.
inhalation 7 hra/
administered by
Expressed as per-
Z-7
Z-l
Half-life of parent compound:     3 days
                                  65 hr»
Half-life of metabolites:

    total trichloro
    compounds
                                                144 hie
                                                123.3 hrs
                                             centage  of original  dose.

                                             human,  100 ppu inhalation  7  hr/        Z-7
                                             day,  5  daya

                                             human,  occupational  exposure          Z-6
                                             human  (male),  30-100  ppm,  inhalation   Z-6
                                             8 lira/day,  5  days/week,  occupational
                                             exposure

-------
               Tetrachloroethylene  (Continued)
                                               Breath
Urine
                                                                             Blood
                                                                                                Comments
                                                                                                                                   Ref.
co
               Half-life of metabolites  (cont.)

                   (total  trichloro
                   compounds, cont.)
               Metabolites;

                   trichloroacetic acid
                   tri chloroethanol
 190.1 hrs
 52X
 5.3 mg/kg
 body wt
 (48 hrs)

 5.5 mg/kg
 body wt
 (48 hrs)

 4-35 mg/L
                                                               32-97 mg/L
 1.8* of
 retained
 tetrachloro-
 ethylene
 (67 lira)

 3.2 mg/kg
 body wt.
 (AS hrs)
human (female), 10-20 ppra, inhalation Z-6
8 hra/day, 5 days/week, occupational
exposure
mouse, 1.3 mg/g body wt, vapor,2 hrs, Z-3
exposure.  Figure represents per-
centage of urinary radioactivity.
Urinary radioactivity was 20Z of
absorbed activity.

rat, 200 ppm inhalation exposure,     Z-4
8 hrs
                                                                                               rat, 2.78 mnol/kg body wt, i.p.       Z-4
human, 20-70 ppm, daily,              Z-4
intermittent occupational
exposure

human, 200-400 ppm daily,             Z-4
intermitten occupational
exposure

human, 87 ppm, inhalation             Z-5
exposure, 3 hrs
rat, 200 ppm, inhalation              Z~4
exposure, 8 hrs

-------
               Tetrachloroethylene (continued)
                                               Breath
Urine
                                                                             Blood
                                                                                                Commenta
                                                                                                                                   Ref.
LO
-t-
               Metabolitea (cont.)

                   (trichloroethanol, cont.)
                   oxalic acid
                   dichloroacetic acid
                   unknown chloride
                   36Cl-activity                 97.91
                   representing parent           (48 lira)
                   compound and/or metabolites
 0.08 mg/kg
 body wt
 (48 hrs)

 4-20 og/L
                                                               21-100 ug/L
 111
                                                               trace
                                                               amount
 l.OZ of
 retained
 tetrachloro-
 ethylene
 (67 hra)

 2. IX
 (48 lira)
 rat, 2.78 mmol/kg body wt i.p.        Z-4
 human,  20-70 ppm, daily,              Z-4
 intermittent occupational
 exposure

 human,  200-400 ppm, daily,            Z-4
 intermittent occupational
•exposure

 mouae,  1.3 mg/g body wt, vapor,       Z-3
 2 hra  exposure.  Figure represents
 percentage of urinary radioactivity.
 Urinary activity waa 202 of
 absorbed activity.

 mouse,  1.3 mg/g body wt, vapor,       Z-3
 2 hrs  exposure.  Figure represents
 percentage of urinary radioactivity.
 Urinary activity was 20Z of absorbed
 activity.

 human,  87  ppm inhalation exposure,    Z-5
 3 hrs
 rat,  1.75  uCi,  administered  by         Z-l
 stomach  tube

-------
              Tetrachloroethylene  (continued)

              	Breath	Urine     	Blood	Comments	Ref.

              Metabolites  (cont.)

                  l^C  activity representing     70T           201 of absorb-                  mouse, 1.3 mg/g body wt               Z-3
                  parent compound  and/or        of absorbed   ed activity                     inhalation, 2 hrs
                  metabolites                   activity

              Metabolite conjugates:            No data       No data        No data
Cn
O

-------
               THICIIUOHOBENZENE
Cn
                                               0
                           IV  o?       V   Q
                                   \   /     ,>
                                     X       XI
                                 I) 1,2,3-trlchlorobenzene
                                II) 1,3,5-trlchlorobenzene
                               III) 1,2,4-trichlorobenzene
                                IV) 2,3,4-trichlorobenzene oxide
                                 V) 3.4,5-trlchlorobenzene oxide
                                VI) 1,3,5-trlchlorobenzene oxide
                               VII) 2,3.5-trlchlorobenzene oxide
                              VIII) 2,4,5-trlchlorobenzene oxide
                                IX) 2,3,6-trichlorophenol
                                 X) 2,3,4-trlchlorophenol
                                XI) 3,4.5-trichlorophenol
                               XII) 2,4,6-trlchloropbenol
                              XIII) 2,3,5-trlchlorophenol
                               XIV) 2,4,5-trlchlorophenol

                               Met aboil am of ,trlchlor,obenzene laomera
                               baaed studies by  Kohll et al., 1976
                               (AA-2).
                                               Breath
                                                              Urine
                                                                             Blood
                                                                                                Comments
                                                                                                                                   Ref.
    1,2,3 iaomer

Parent compound:

Half-life of parent compound:

Metaboli tea;

    tr i chloropbenola
    (primarily 2,3,4~trichloro-
    phenol;  smaller amounts
    of 3,4 ,5-trichlorophenol
    and 3,4,5-trichlorocatechol)

    2, 3 ,4-tri cb1orophenol
                                                 No data

                                                 No data
Mo data

No data
                                                               7BX
                                                               (5 days)
                                                               III
                                                               (10 days)
No data

No data
                                rabbit,  0.5 g/kg,  by
                                stomach  tube
                                rabbit,  300  pig,  i .p.
                                                       AA-1
                                                                      AA-2

-------
                Trichlorobenzene  (continued)
                                                Breath
                                                               Urine
                                                                              Blood
                                                                                                 Comments
                                                                                                                                    Ref.
Metabolites (cont.)
2,3,6-trichlorophenol
3,4,5-trichloroptienyl
acetate
Metabolite conjugates)
glucuroni de
ethereal sulphate
2,3,4-trichlorophenyl-
raercapturic acid

11
(10 days)
n
(10 days)

50%
(5 days)
12%
(5 days)
0.3X
(5 days)

rabbit, 300 rog, i .p.
rabbit, 300 mg, i .p.

rabbit, 0.5 g/kg,
by stomach tube
rabbit, 0.5 g/kg by
stomach tube
rabbit, 0.5 g/kg, by
stomach tube

M-2
AA-2

AA-1
AA-1
AA-1
Cn
N>

-------
Tri chlorobenzene (continued)
                                Breach
                                               Urine
                                                              Blood
                                                                                 Comments
Ref.
1,2,4 isomer
Parent compound) No data
Half-life of parent compound! No data
Metabolites!
trichloro phenols
(2,4,5- and 2,3,5-
trichlorophenol, plus
small amounts of 3,4,6-
trichlorocatechol)
2,4 , 5- trichloro phenol
2,3,5-trichlorophenol
Metabolite conjugates!
glucuronide
ethereal sulphate
mercapturic acids
(2,3,5- and 2,4,5-
No data fo data
No data No data

42Z
(5 days)
51
(10 days)
(10 days) ;

27Z
(5 days)
111
(5 days)
0.3Z
(5 days)



rabbit, O.S g/kg, by
stomach tube
rabbit, 300 mg, i .p.
rabbit, 300 mg, i .p.

rabbit, 0.5 g/kg, by
stomach tube
rabbit, 0.5 g/kg, by
stomach tube
rabbit, 0.5 g/kg, by
stomach tube



AA-1
AA-2
AA-2

AA-1
AA-1
AA-1
    tri chlorophenyl mercap-
    turic acids)

-------
             Trichlorobenzerie  (continued)
l/l
                                             Breath
Urine
                                                                          Blood
                                                                                             Comments
l^JSjJMlSSiEi
Parent compounds

Half-life of parent compound:
Metabolites?
2,4,6-trichlorophenol


other phenols
(4-chlorophenol and
4-chlorocatechol )
monoch 1 or oben zene
Metabolite conjugates:
glucuronide
ethereal sulphate
121
(8 days)
8.5X
(9 days)
No data Ho data Ho data

9%
3J
(8 days)
10X
(9 days)
IX
(8 days)
1*1
(9 days)
IX
(8 or 9 days)

20X
(5 days)
3X
(5 days)
rabbit, 0-5 g/kg,
by stomach tube
rabbit, 0.5 g/kg,
by stomach tube


rabbit, 0,5 g/kg,
by stomach tube
rabbit, 0.5 g/kg,
by stomach tube
rabbit, 0.5 g/kg,
by stomach tube
rabbit, 0.5 g/kg,
by stomach tube
rabbit, 0.5 g/kg,
by stomach tube
rabbit, 0.5 g/kg,
by stomach tube

rabbit, 0.5 g/kg,
by stomach tube
rabbit, 0.5 g/kg,
by stomach tube
AA-3
AA-3


M-l
AA-3
AA-3
AA-3
AA-3
AA-3

AA-1
AA-l
                mercapturic acid
                                 rabbit,  0.5  g/kg,
                                 by  stomach tube
                                                                                                                                  AA-1

-------
             1.1,1-TKICHLOROETHANE
                                                oxidation
                                                                 .  Cl CCH 01}
                                                                 '  trichloroethanol
                                             v Cl COCOOU
                                            ~^:rlchloroacetic acid
                                 Proposed formation of urinary metabolites of  1,1,1-trichloroethane,  from Ikeda and
                                 Ohtsuji, 1972  (Afl-2)
CO
Cn
Cn
                                             Breath
                                                            Urine
                            Blood
                                                                                              Comments
                                    Ref.
             Parent  compounds

                 (a) alveolar  air
                 concentration of
                 1,1,1-trichloroethane
125 ppm (a)
(at reat)
                                               168 ppm (a)
                                               (50 W)
human, 250 ppm exposure, 30 mill, per  AB-5
exposure, at reat and with consecutive
work loads of 50, 100, and 150 W as
measured on a bicycle ergometer

human, 250 ppm exposure, 30 min. per  AB-5
exposure, at reat and with consecutive
work loads of 50, 100, and 150 W aa
measured on a bicycle ergometer

-------
               1,1,1-Trichloxoethane (continued)

                                               Breath
Urine
Blood
                                                                                                Comments
                                                                                                                                   Ref.
               Parent compound (cont.)
                                                 210 ppra (a)
                                                 (100 W)
                                                 27 ppra (a)
                                                 (150 W)
to
01
ON
                                                                              3.0 ppm
                                                                              arterial blood
                                                                              (at rest)
                                                                              4.5 ppm
                                                                              arterial blood
                                                                              (50 W)
                                                                              5.2 ppm
                                                                              arterial blood
                                                                              (100 W)
                                                                              5.5 ppm
                                                                              arterial blood
                                                                              (150 W)
                                 human, 250 ppm exposure,  30 min.  per  AB-5
                                 exposure, at rest and with consecutive
                                 work loads of 50, 100, and 150 W as
                                 measured on a bicycle ergoroeter

                                 human, 250 ppm exposure,  30 min.  per  AB-5
                                 exposure, at rest and with consecutive
                                 work loads of 50, 100, and 150 W as
                                 measured on a bicycle,ergometer

                                 human, 250 ppm exposure,  30 min.  per  AB-5
                                 exposure, at rest and with consecutive
                                 work loads of 50, 100, and 150 H as
                                 measured on a bicycle ergometer

                                 human, 250 ppm exposure,  30 nin. per  AB-5
                                 exposure, at rest and with consecutive
                                 work loads of 50, 100, and 150 W as
                                 measured on a bicycle ergometer

                                 human, 250 ppm exposure,  30 rain, per  AB-5
                                 exposure, at rest and with consecutive
                                 work loads of 50, 100, and 150 H as
                                 measured on a bicycle ergometer

                                 human, 250 ppm exposure,  30 min. per  AB-5
                                 exposure, at rest and with consecutive
                                 work loads of 50, 100, and 150 W as
                                 measured on a bicycle ergometer

-------
1,1,1-Trichloroebhana (continued)
                                Breath
                                               Urine
                                                              Blood
                                                                                 CommentB
                                                                                                                    Bet.
Parent compound (cont.)
                                  179 pprt,
                                  alveolar air
                                  (at rest)
                                  239 ppm,
                                  alveolar air
                                  (50 W)
1.4 ppm,         human, 250 ppm exposure, 30 mitt, per  AB-5
venous blood     exposure, at reat and with consecutive
(at reat)        work loada of 50, 100, and 150 W as
                 measured on a bicycle ergometer

3.1 ppm,         human, 250 ppm exposure, 30 min. per  AB-5
venous blood     exposure, at rest a»d with consecutive
(50 W)           work loada of 50, 100, and 150 M as
                 measured on a bicycle ergometer

3.5 ppm,         human, 250 ppm exposure, 30 min. per  AB-5
venous blood     exposure, at reat and with consecutive
(100 W)          work loada of 50, 100, and 150 M aa
                 measured on a bicycle ergometer

4.4 ppm,         human, 250 ppm exposure, 30 min. per  AB-5
venous blood     exposure, at reat and with consecutive
(150 W)          work loads of 50, 100, and 150 W as
                 measured on a bicycle ergometer

                 human, 350 ppm exposure, 30 min. per  AB-5
                 exposure, at reat and with 50 H
                 work load aa measured on a bicycle
                 ergometer

                 human, 350 ppra exposure, 30 min. per  AB-5
                 exposure, at reat and with 50 W
                 work load as measured on a bicycle
                 ergometer

-------
         1,1,1-Trichloroethane (continued)

                                         Breath
         Parent compound (cont.)
oo
<_n
Co
Urine
                                           128 ppm,
                                           alveolar  air
                                           (at rent)
                                           176 ppm,
                                           alveolar  air
                                           (at rest
                                           plus 4Z
                                           CO2)

                                           201 ppm,
                                           alveolar  air
                                           (50 H
                                           plus 4X
Blood
                                                                                          Comments
                                                                     Ref.
                                                                        5.0 ppm,
                                                                        arterial blood
                                                                        (at rest)
                                                                        7.2 ppm,
                                                                        arterial blood
                                                                        (50 W)
                                                                        3.0 ppm,
                                                                        venous blood
                                                                        (at reat)
                4.0 ppm
                venous blood
                (50 W)
                  human, 350 ppm exposure, 30 rain, per  AB-5
                  exposure, at rest and with 50 H work
                  toad as measured on a bicycle
                  ergometer ,

                  human, 350 ppm exposure, 30 min. per  AB-5
                  exposure, at rest and with 50 H work
                  load as measured on a bicycle
                  ergometer

                  human, 350 ppm exposure, 30 min. per  AB-5
                  exposure, at rest and with 50 W work
                  load aa measured on' a bicycle
                  ergometer

                  human, 350 ppm exposure, 30 min. per  AB-5
                  exposure, at rest and with 50 H work
                  load as measured on a bicycle
                  ergometer

                  human, 250 ppm exposure, 30 min. per  AB-5
                  exposure; at rest, at rest plus AX
                  C(>2, and 50 W workload plus 4Z
                  CO 2
                                 human, 250 ppm exposure, 30 min. per
                                 exposure; at rest, at rest plus 42
                                 CO2, and 50 H workload plus 4Z
                                 C02
                                                                                                                               AB-5
                                 human, 250 ppm exposure, 30 min. per
                                 exposure; at rest, at reat plus 4Z
                                 C02, and 50 W workload plus 4Z
                                 CO 9
                                                        AB-5

-------
          1,1,1-Trichloroethane (continued)

          	Breath
Urine
               Blood
                                  Comment: a
                                                                      Ref.
          Parent compound (cont.)
U>
Ln
                                                                         2.2 ppm,
                                                                         arterial blood
                                                                         (at reat)
                3.3 ppm,
                arterial blood
                (at reat plus
                AX C02)

                3.9 ppm,
                arterial blood
                (50 W plus
                AX C02)
                1.0 ppm,
                venouu blood
                (at rest)
                                                                         1.2 ppm,
                                                                         venous blood
                                                                         (at reat plua
                                                                         AX C02)

                                                                         1.9 ppm,
                                                                         venous blood
                                                                         (50 U  plua
                                                                         AX C02)
human, 250 ppm exposure, 30 min.  per   AB-5
exposure; at rest, at  reat plua At
(X>2, and 50 W workload plua AX
C02

human, 250 ppn exposure, 30 min.  per   AB-5
exposure; at rest, at reat plua AX
C02, and 50 W workload plus AX
C02

human, 250 ppm exposure, 30 min.  per   AB-5
exposure; at rest, at reat plua AX
CO?, and 50 W workload plus AX
UU9

human, 250 ppm exposure, 30 min.  per   AB-5
exposure; at rest, at reat plua AX
C02, and 50 U workload plua AX
C02

human, 250 ppm exposure, 30 min.  per   AB-5
exposure; at rest, at rest plus AX
C02, and 50 U workload plus AX
CO2

human, 250 ppm exposure, 30 min.  per   AB-5
exposure; at rest, at rest plua AX
C02, and 50 U workload plus AX
CO 2

-------
          1,1,1-Tri chloroethane (continued)

                                         Breath
Urine
                                                                       Blood
                                                                                          Comments
                                                                                                                            Ref.
         Parent compound (cont.)
OJ
Ov
O
                                           98.7X
                                           (25 hrs)

                                           2.488 mg
                                           (1st hr)
                                           1.156 mg
                                           (2nd hr)
                                           0.589 mg
                                           (3rd hr)
                                           0.309 mg
                                           (4th hr)
                                           0.191 mg
                                           (5th hr)
                                           0.117 mg
                                           (6th hr)
                                           0.073 mg
                                           (7th hr)
                                           0.050 mg
                                           (8th hr)
                                 rat.  700 mg 1,1,1-trichloroethane-    AB-1
                                 1-C14 per kg,  i.p.

                                 rat,  221 ppm,  inhalation exposure     AB-3
                                 (4 hrs); expired air  level  of
                                 parent compound  measured hourly

                                 rat,  221 ppm,  inhalation exposure     AB-3
                                 (4 hrs); expired air  level  of
                                 parent compound  measured hourly

                                 rat,  221 ppm,  inhalation exposure     AB-3
                                 (4 hrs); expired air  level  of
                                 parent compound  measured hourly

                                 rat,  221 ppm,  inhalation exposure     AB-3
                                 (4 hrs); expired air  level  of
                                 parent compound  measured hourly

                                 rat,  221 ppm,  inhalation exposure     AB-3
                                 (4 hrs); expired air  level  of
                                 parent compound  measured hourly

                                 rat,  221 ppm,  inhalation exposure     AB-3
                                 (4 hrs); expired air  level  of
                                 parent compound  measured hourly

                                 rat,  221 ppm,  inhalation exposure     AB-3
                                 (4 hrs); expired air  level  of
                                 parent compound  measured hourly

                                 rat,  221 ppm,  inhalation exposure     AB-3
                                 (4 hra); expired air  level  of
                                 parent compound  measured hourly

-------
         1,1, 1-Trichloroethane (continued)

                                         Breath
Urine
                                                                       Blood
                                                                                          Commenta
Bef.
         Parent compound (cont.)
u>
ON
                                           5.719 mg
                                           (1st hr)
                                           3.350 mg
                                           (2nd hr)
                                            1.539 mg
                                            (3rd hr)
                                           0.793 mg
                                           (4th hr)
                                           0.441 mg
                                           (5th hr)
                                           0.259 mg
                                           (6th hr)
                                           0.154 mg
                                           (7th hr)
                                           0.098 rag
                                           (8th hr)
                                 rat, 443 ppm, inhalation exposure     AB-3
                                 (4 hrs)| expired air level of
                                 parent compound measured hourly

                                 rat, 443 ppm, inhalation exposure     AB-3
                                 (4 hra)j expired air level of
                                 parent compound measured hourly

                                 rat, 443 ppm, inhalation exposure     AB-3
                                 (4 hrs)j expired air level of
                                 parent compound measured hourly

                                 rat, 443 ppm, inhalation exposure     AB-3
                                 (4 hrs)j expired air level of
                                 parent compound measured hourly

                                 rat, 443 ppm, inhalation exposure     AB-3
                                 (4 hrs)) expired air level of
                                 parent compound measured hourly

                                 rat, 443 ppm, inhalation exposure     AB-3
                                 (4 hra)j expired air level of
                                 parent compound measured hourly

                                 rat, 443 ppm, inhalation exposure     AB-3
                                 (4 hra); expired air level of
                                 parent compound measured hourly

                                 rat, 443 ppia, inhalation exposure     AB-3
                                 (4 hrs)j expired air level of
                                 parent compound measured hourly

-------
        1,1,1-Trichloroethane (continued)

                                        Breath
Urine
Blood
                                  Comments
Ref.
        Parent compound (cont.)
ON
                                                                       0.677-1.000
                                                                       ug/ml
                                                                       0.08 nraol/g
                                                                       (17 hre after
                                                                       last exposure)
                                 rat, 204 ppm inhalation exposure,
                                 8 hrs/day, 5 days/week, 14 weeks;
                                 blood concentration of parent
                                 compound determined periodically
                                 for duration of exposure

                                 rat, 20 umol/L (500 ppm),
                                 inhalation exposure, 6 hrs/day,
                                 4 days
                                                        AB-3
                                                        AB-8
                                                                                                                              AB-8
                8.5 to 13.1      rat, 20 umol/L (500 ppm),
                nraol/g (limned-   inhalation exposure, 6 hra/day,
                lately after 2-  4 days
                6 hra additional
                exposure on day 5)

                0.15 ug/g        mouse, 10 ppm inhalation exposure     AB-9
                (3 hrs)          for 3, 6, or 24 hours

                0.47 ug/g        mouse, 10 ppm inhalation exposure     AB-9
                (6 hrs)          for 3, 6, or 24 hours

                0.60 ug/g        mouse, 10 ppm inhalation exposure     AB-9
                (24 hrs)         for 3, 6, or 24 hours

                3.0 ug/g         mouse, 100 ppm inhalation exposure    AB-9
                (0.5 hr)         for various exposure periods

                4.8 ug/g         mouse, 100 ppm inhalation exposure    AB-9
                (1 hr)           for various exposure periods

                4.2 ug/g         mouse, 100 ppm inhalation exposure    AB-9
                (2 hrs)          for various exposure periods

-------
            1,1,1-Trichloroethane  (continued)

                                            Breath
Urine
Blood
                                                                                             Comments
                                                      Hef.
            Parent  compound  (cont.)
ON
Cx)
                4.5 ug/g
                (3 hrs)

                8.1 ug/g
                (4 hrs)

                5.6 ug/g
                (4.5 hra)

                6.2 ug/g
                (5 hra)

                6.0 ug/g
                (6 hra)

                5.8 ug/g
                (16 hra)

                6.3 ug/g
                (24 hra)

                31 ug/g
                (0.5 hr
                exposure)

                38 ug/g
                (l hr exposure)

                41 ug/g
                (3 hrs exposure)

                48 ug/g
                (4.5 hrs
                exposure)

                36 ug/g
                (6 hra exposure)
mouse,  100 ppm  inhalation exposure
for various exposure periods

mouse,  100 ppn  inhalation exposure
for various exposure periods

mouse,  100 ppm  inhalation exposure
for various exposure periods

mouse,  100 ppm  inhalation exposure
for various exposure periods

mouse,  100 ppm  inhalation exposure
for various exposure periods

mouse,  100 ppm  inhalation exposure
for various exposure periods

mouse,  100 ppm  inhalation exposure
for various exposure periods

mouse,  1000 ppm inhalation exposure
for 0.5, 1, 3, 4.5, or 6 hours
                  mouse,  1000 ppm inhalation exposure
                  for 0.5,  1, 3,  4.5,  or 6 hours

                  mouse,  1000 ppm inhalation exposure
                  for 0.5,  I, 3,  4.5,  or 6 hours

                  mouse,  1000 ppin inhalation exposure

                  for 0.5,  1, 3,  4.5,  or 6 hours

                  mouse,  1000 ppm inhalation exposure
                  for 0.5,  1, 3,  4.5,  or 6 hours
                                                                                                                                  AB-9
                                                                                                                                  AB-9
                                                                                                                                  AB-9
                                                                                                                                  AB-9
                                                        AB-9
                                                                                                                                  AB-9
                                                                                                                                  AB-9
                                                                                                                                  AB-9
                                                                                                                                  AB-9
                                                                                                                                  AB-9
                                                                                                                                  AB-9
                                                                                                                                  AB-9

-------
        !,1,1-Tri chloroethane  (continued)

                  	                 Breath
             Urine
                            Blood
                                               Comments
                                                                                  Ref.
U>
ON
       Parent compound (cont.)
       Half-life of parent compound:
       Metabolites;
           14
             CO 2
           tri chloroethanol
0.5%
(25 hrs)
              8.7 hrs
              (average)
                             103 ug/g
                             (0.5 hr
                             exposure)

                             144 ug/g
                             (1 hr
                             exposure)

                             165 ug/g
                             (3 hrs
                             exposure)

                             251 ug/g
                             (0.5 hr
                             exposure)

                             204 ug/g
                             (3 hrs
                             exposure)

                             404 ug/g
                             (6 hrs
                             exposure)
              20.1 rag/24 hrs
              (1st day)

              30.1 mg/24 hra
              (2nd day)
                                                                                       mouse, 5,000 ppm inhalation           AB-9
                                                                                       exposure, for 0.5, 1, or 3 hours


                                                                                       mouse, 5,000 ppm inhalation           AB-9
                                                                                       exposure, for 0.5, 1, or 3 hours
                                                                                       mouse, 5,000 ppm inhalation           AB-9
                                                                                       exposure, for 0.5, I, or 3 hours
mouse, 10,000 inhalation exposure     AB-9
for 0.5, 3, or 6 hours
                                                                                       mouse, 10,000 inhalation exposure     AB-9
                                                                                       for 0.5, 3, or 6 hours
                                                                                       mouse, 10,000 inhalation exposure     AB-9
                                                                                       for 0.5, 3, or 6 hours
human, occupational inhalation        AB-7
exposure to 4, 25, 28, or 53 ppm,
for 8 hrs/day, 5-1/2 days/week,
for at least 5 years (average)
rat. 700 mg 1,1,1-trichloroethane-    AB-1
1-C1* per kg, i.p.

human, 500 ppm inhalation exposure    AB-6
6 1/2-7 hrs/day, 5 days

human, 500 ppm inhalation exposure    AB-6
6 1/2-7 hrs/day, 5 days

-------
          I,1,1-Trichloroethane  (continued)

                                          Breath
Urine
Blood
                                                                                           Comments
                                                       fief.
         Metabolites  (cont.)
              (trichloroethanol,  cont.)
OJ
ON
Ui
 29.3 mg/24 bra
 (3rd day)

 46.6 mg/24 hrs
 (4th day)

 7.0 mg/24 lira
 (6th day
 after last
 exposure)

 less than 1.0
 mg/24 hrs
 (12th day after
 last exposure)

 1.2 rag/L
 (4.3 ppm
 exposure)
                                                          5.5 mg/L
                                                          (24.6 ppm ex-
                                                          posure)
                                                          9.9 mg/L
                                                          (53.4 ppm ex-
                                                          posure)
                  human, 500 ppm inhalation exposure
                  6 1/2-7 hrs/day, 5 days

                  human, 500 ppm inhalation exposure
                  6 1/2-7 hrs/day, 5 days

                  human, 500 ppm inhalation exposure
                  6 1/2-7 hrs/day, 5 days
AB-6
                                                                                                                                AB-6
                                                                                                                                AB-6
                  human, 500 ppm inhalation exposure    AB-6
                  6 1/2-7 hrs/day, 5 days
                  human, occupational inhalation ex-    AB-7
                  posure to 4.3, 24.6, or 53.4 ppm for
                  6 hrs/day, 5 1/2 days/week, for at
                  least 5 years

                  human, occupational inhalation ex-    AB-7
                  posure to 4.3, 24.6, or 53.4 ppm for
                  8 lira/day, 5 1/2 days/week, for at
                  least 5 years

                  human, occupational inhalation ex-    AB-7
                  posure to 4.3, 24.6, or 53.4 ppm for
                  6 hrs/day, 5 1/2 days/week, for at
                  least 5 years

-------
           1,1,1 -Tricliloroethane  (continued)

                                           Breath
Urine
               Blood
                                                                                           Comments
                                                                                                                              Ref.
          Metabolites  (cont.)

               (trichloroethanol,  cont.)
Ox
 3.1 mg/kg
 (48 hrs)

 3.5 mg/kg
 (48 hrs)

 126.2 ug
 (24 hrs)

 7.5 ug
 (2nd 24-hr
 period)

 206.5 ug
 (24 hrs)

 8.6 ug
 (2nd 24-hr
 period)
rat, 200 ppro inhalation exposure      AB-2
8 hours
                                                                                          rat,  2.78 nmol/kg,  i.p.
                                                                                           rat,  443  ppra  inhalation  exposure,
                                                                                           4  hrs

                                                                                           rat,  443  ppra  inhalation  exposure,
                                                                                           4  hrs
                                                                         0.088 ug/ml       rat,  chronic  inhalation  exposure,
                                                                         (week 1)          204  ppra  Cor 8 hrs/day, 5 days/week
                                                                                           for  14 weeks; trichloroethanol  in
                                                                                           blood measured periodically  during
                                                                                           exposure at 1,2,4  and 9  weeks

                                                                         0.063 ug/ml       rat',  chronic  inhalation  exposure,
                                                                         (week 2)          204; ppm  Cor 8 hrs/day, 5 days/week
                                                                                           for  14 weeks; trichloroethanol  in
                                                                                           blopd measured periodically  during
                                                                                           exposure at 1,2,4  and 9  weeks
                                      AB-2
                                                                                          rat,  221 ppm  inhalation  exposure      AB-3
                                                                                          4 hours

                                                                                          rat,  221 ppm  inhalation  exposure,     AB-3
                                                                                          4 hours
                                      AB-3


                                      AB-3



                                      AB-3
                                                                       AB-3

-------
             1,1,1-Trichloroethane  (continued)

              	               Breath
Urine
Blood
                                  Comments
Ref.
             Metabolitea  (cont.)

                 (trichloroethanol,  cont.)
CO
a\
 93.0 ug/24 hra
 (week 1)
                                                             222.9  ug/24  hrs
                                                             (week  2)
                                                             189.8 ug/24  hra
                                                             (week 3)
                                                             216.3 ug/24  hrs
                                                             (week it)
 0.059 ug/ml      rat, chronic inhalation exposure,     AB-3
 (week 4).         204 ppm Cor 8 hrs/day, 5 days/week
                  for 14 weeks; trichloroethanol in
                  blood measured periodically during
                  exposure at 1,2,4 and 9 weeks

 0.071 ug/ml      rat, chronic inhalation exposure,     AB-3
 (week 9)         204 ppm for 8 hrs/day, 5 days/week
                  for 14 weeks} trichloroethanol in
                  blood measured periodically during
                  exposure at 1,2,4 and 9 weeks

                  rat, chronic inhalation exposure,     AB-3
                  204 ppm for 8 hra/day, S days/week
                  for 14 weeks, trichloroethanol in
                  urine measured weekly

                  rat, chronic inhalation exposure,     AB-3
                  204 ppm for 8 hrs/day, 5 days/week
                  for 14 weeks, trichloroethanol in
                  urine measured weekly

                  rat, chronic inhalation exposure,     AB-3
                  204 ppm for 8 hra/day, 5 days/week
                  for 14 weeks, trichloroethanol in
                  urine measured weekly

                  rat, chronic inhalation exposure,     AB-3
                  204 ppm for 8 hrs/day, 5 days/week
                  for 14 weeks, trichloroethanol in
                  urine measured weekly

-------
              1,1,1-Trichloroethane  (continued)

                                             Breath
Urine
                                                                           Blood
                                                                                              Comments
                                                                                                                                 Ref.
             Metabolites  (cont.)

                  (trichloroethanol,  cont.)
oo
 254.5 ug/24 hrs
 (week 5)
                                                             194.1 ug/24 hra
                                                             (week 6)
                                                             302.8 ug/24 hra
                                                             (week 7)
                                                             339.0 ug/24 hrs
                                                             (week 8)
                                                             383.9 ug/24 hrs
                                                             (week 9)
                                                             435.1 ug/24 hrs
                                                             (week 10)
rat, chronic inhalation exposure,     AB-3
204 ppm for 8 hrs/day, 5 days/week
for 14 weeks, trichloroethanol in
urine measured weekly

rat, chronic inhalation exposure,     AB-3
204 ppm for 8 hrs/day, 5 days/veek
for 14 weeks, trichloroethanol in
urine measured weekly

rat, chronic inhalation exposure,     AB-3
204 ppm for 8 hrs/day, 5 days/week
for 14 weeks, trichloroethanol in
urine measured weekly

rat, chronic inhalation exposure,     AB-3
204 ppm for 8 hrs/day, 5 days/week
for 14 weeks, trichloroethanol in
urine measured weekly

rat, chronic inhalation exposure,     AB-3
204 ppm for 8 hrs/day, 5 days/week
for 14 weeks, trichloroethanol in
urine measured weekly

rat, chronic inhalation exposure,     AB-3
204 ppm for 8 hrs/day, 5 days/week
for 14 weeks, trichloroethanol in
urine measured weekly

-------
1,1,1-Trichloroethane (continued)

                                Breath
Urine
                                                              Blood
                                                                                 Commenta
                                    Ref.
Metabolites, (cont.)

    (trichloroethanol, cont.)
    trichloroacetic acid
 305.7 ug/24 hra
 (week 11)
                                                291.7 ug/24 hra
                                                (week 12)
                                                372.2 ug/24 hra
                                                (week 13)
                                                362.2 ug/24 hrs
                                                (week 14)
 7.5 mg/24 hra
 (lat day)

 10.9 mg/24 hra
 (2nd day)

 12.3 mg/24 hra
 (3rd day)

 14.1 mg/24 hrs
 (4th day)
rat, chronic inhalation exposure,     AB-3
204 ppm for B hra/day, 5 days/week
for 14 weeks, trichloroethanol in
urine measured weekly

rat, chronic inhalation exposure,     AB-3
204 ppm for 8 hra/day, 5 days/week
for 14 weeka, trichloroethanol in
urine measured weekly

rat, chronic inhalation exposure,     AB-3
204 ppm for 8 hra/day, 5 days/week
for 14 weeka, trichloroethanol in
urine measured weekly

rat, chronic inhalation exposure,     AB-3
204 ppm for 8 hra/day, 5 daya/week
for 14 weeka, trichloroethanol in
urine measured weekly

human, 500 ppm,  inhalation exposure,  AB-6
6 1/2-7 hra/day, 5 daya
      \
human, 500 ppm,  inhalation exposure,  AB-6
6 1/2-7 hrs/day, 5 days

human, 500 ppm,  inhalation exposure,  AB-6
6 1/2-7 hra/day, 5 days

human, 500 ppm,  inhalation exposure,  AB-6
6 1/2-7 hrs/day, 5 days

-------
1,1,1-Trichloroethane (continued)

                                Breath
Urine
                                                              Blood
                                                                                 Comments
                                                                                                                    Ref.
Metabolites (cont.)

    (tricbloroacetic acid, cont.)
 18.0 mg/24 hra
 (6th day after
 last exposure)

 17.5 rog/24 hra
 (12th day
 after last
 exposure

 0.6 mg/L
#<4.3 ppm
 exposure)
                                                2.4 mg/L
                                                (24.6 ppm
                                                exposure)
                                                3.6 mg/L
                                                (53.4 ppm
                                                exposure)
                                                0.5 mg/kg
                                                body wt
                                                (48 hrs)

                                                0.5 mg/kg
                                                body wt
                                                (48 hrs)
human, 500 ppm, inhalation exposure,   AB-6
6 1/2-7 hrs/day, 5 days
                                                                                human, 500 ppm, inhalation exposure,   AB-6
                                                                                6 1/2-7 hrs/day, 5 days
human, occupational inhalation ex-    AB-7
posure to 4,3, 24.6, or 53.4 ppm for
8 hra/day, 5 1/2 days/week, for at
least 5 years

human, occupational inhalation ex-    AB-7
posure to 4,3, 24.6, or 53.4 ppm for
8 hrs/day, 5 1/2 days/week, for at
least 5 yeara

human, occupational inhalation ex-    AB-7
posure to 4.3, 24.6, or 53.4 ppm for
8 hrs/day, 5 1/2 days/week, for at
least 5 yeara

rat, 200 ppm inhalation exposure, 8   AB-2
hours
                                 rat, 2.78 mmol/kg, i.p.
                                      AB-2

-------
1,1,1-Trichloroethane (continued)

                                Breath
Urine
                                                              Blood
                                                                                 Comments
                                                                                                                    Ref.
Metabolites (cont.)

    (trichloroacetic acid, cont.)
 0.3 mg/kg
 body vt
 (2nd 48-)
 hr period)

 3.2 ug
 (24 hrs)

 8.1 ug
 (2nd 24-)
 hr period)

 9.5 ug
 (24 hra)

 10.6 ug
 (2nd 24-
 hr period)

 7.5 ug
 (3rd 24-
 hr period)

 12-20 ug
 (daily
 average)
rat, 2.78 omol/kg, i.p.
AB-2
                                                                                rat, 221 ppm inhalation exposure,     AB-3
                                                                                4 hra

                                                                                rat, 221 ppm inhalation exposure,     AB-3
                                                                                4 hrs
                                                                                rat, 443 ppm inhalation exposure,     AB-3
                                                                                4 hours

                                                                                rat, 443 ppm inhalation exposure,     AB-3
                                                                                4 hours
                                                                                rat,  443 ppm inhalation exposure,      AB-3
                                                                                4 hours
                                                                                rat,  204 ppm inhalation exposure,      AB-3
                                                                                8 hrs/day,  5 daya/week, for
                                                                                14 weeks

-------
 1,1,1-Trichloroethane  (continued)

                                Breath
             Urine
                                                              Blood
                                                                                 Comments
                                                                                                                    Ref.
Metabolite conjugates:

    12>C- activity,
    primarily
    2,2,2-trichloroethanol
    -2-C*4 glucuronide

Other!

    38Cl-activity


    ^C-activity
44X
              0.851
              (24 hrs)
                             0.02%
                             (25 hrs)
rat, 700 rag 1,1,1-trichloroethane     AB-1
-1—C" per kg, i.p.
human, 5 rag 38Cl-l,1,1-trichloro-     AB-4
ethane, inhalation (single breath)
rat. 700 mg 1,1,1-trichloroethane-
l-C*'* per kg, i.p.
AB-1

-------
1,1, 2-TBICHLOROETHANE
                        b             c
                 CHOII « - CIlCl CHCI — : --- »
d   «        e    *
 CHO-CH(C1 --_—-* aiO'CHj
t   1       ••'"'
;i>"
                         Hoac CHj-s-cnk-cii|:VH t-cooH

                                                                    a)   3,2-dichloroethanol
                                                                    b)   1,1,2-trichloroethane
                                                                    c)   S-(J,2-dichloroethyl)-glutathio(ie
                                                                    d)   chloroacetaldehyde
                                                                    e)   S-formylmethylglutathione
                                                                    f)   chloroacetic acid
                                                                    g)   S-carboxymethylglutathlone
                                                                    h)   3-carboxymethylcyateine
                                                                    i)   thlodiaceclc acid
                                                          arrows indicate tha suggested  routes
                                                    and the dotted arrows the alternatives.
                                                  Metabolic fate of 1, 1,2-trtchloroethane.  (From ref. AC-1)
                              Breath
                                            Urine
                                                          Blood
                                                                            Comments
Parent compound:                 approx. 6.4-
                                "•8*
                                (3 days)

Half-life  of  parent compound!     No data       No data

Metaboli teat

    Uc°2                        appro*. 9.6-
                                13. 2Z
                                (3 days)
                                                           ..No data
                                                   mouse,  0.1-0.2 g 14C-1,1,2-
                                                   trichloroethane per kg,  i.p.
                                                                            V
                                                   mouse, 0.1-0.2 g ^C-1,1,2-
                                                   trichloroethane per kg,  i.p.
                                                                                                               AC-1
                                                                                                               AC-1

-------
           1,1,2-Trichloroethane  (continued)

                                          Breath
Urine
               Blood
                                                                                           Comments
                                                                                                                              Ref.
          Metabolites  (cont.)

              tri chloroethanol
co
^-4
-P-
              2,2,2-trichloroethanol
              2,2, -di ch 1oroethanol
 0.3 mg/kg,
 body wt
 (48 hrs from
 start of ex-
 posure)

 0.2 mg/kg
 body wt
 (48 hrs from
 start of
 exposure)

 trace (2nd
 48-hr
 period

 0.2Z of total
 urinary
 radiocativity;
 equivalent to
 about 0.16* of
 14C-1,I,2-
 trichloroethane dose
 (3 days)

 1.4Z of total
 urinary
 radiocativityj
 equivalent to
 about 1.121 of
 "C-1,1,2-
 trichloroethane dose
 (3 daya)
rat, 200 ppm inhalation exposure,     AC-2
8 hours
                                                                                          rat, 2.78 nmol/kg, i.p.
                                                                                          rat, 2.78 pmol/kg, i.p.
mouse, 0.1-0.2 g of I4C-1,1,2-
trichloroethane, i.p.
                                      AC-2
                                      AC-2
AC-1
mouse, 0.1-0.2 g of ^C-1,1,2-
trichloroethane, i.p.
AC-1

-------
              1,1,2-Trichloroethane (continued)

                                              Breath
Urine
                                                                            Blood
                                                                                               Commenta
                                     Bef.
             Metabolites  (cont.)

                  trichloroacetic  acid
Ul
                  chloroacetic acid
 0.3 mg/kg
 body wt
 (48 hra
 from
 atart of
 exposure)

 0.4 mg/kg
 body wt
 (48 hra)

 0.3 mg/kg
 body wt
 (2nd 48-
 hr period)

 1.9X of total
 urinary radio-
 activity! equiv-
 alent to about
 1.52Z of ^c-
 1,1,2-trichloro-
 ethane dose
 (3 daya)

 16.Z of total
 urinary radio-
 activity) equiv-
 alent to about
 12.78* of l*C-
 1,1,2-trichloro-
 ethane doae
 (3 daya)
rat, 200 ppm inhalation expoaure,      AC-2
8 hours
                                                                                              rat, 2.78 mmol/kg, i.p.
                                                                                              rat, 2.78 muol/kg,  i.p.
                                                                                              mouae,  0.1-0.2 g of
                                                                                              trichloroethane, i.p.
                                      AC-2
                                      AC-2
                                      AC-1
mouae, 0.1-0.2 g of 1
trichloroethane, i.p.
AC-I

-------
1,1,2-Tricbloroethane (continued)

                                Breath
Urine
                                                              Blood
                                                                                 Commenta
                                                                                                                    Ref.
Metabolites (cont.)

    S-carboxymethyicysteine
    conjugated S-carboxy-
    methylcysteine
    thiodiacetic acid
    oxalic  acid
 38.% of total
 urinary radio-
 activity;  equiv-
 alent to about
 30.36% of 14C-
 1,1,2-trichloro-
 ethane dose
 (3 days)

 5.X of total
 urinary radio-
 activity)  equiv-
 alent to about
 4.01 of 1*0-
 1,1,2-trichloro-
 ethane dose
 (3 days)

 407 of total
 urinary radioh
 activityj  equiv-
 alent to about
 31.96Z of 1*0-
 1,1,2-trichloro-
 ethane dose
 (3 days)

 0.4X of total
 urinary radio-
 activity;  equiv-
 alent to about
 0.32* of ^C-
 1,1,2-trichloro-
 ethane dose
 (3 days)
mouse, 0.1-0.2 g of l*C-1,1,2-
trichloroethane, i.p.
                                                                                                                      AC-1
mouse, 0.1-0.2 g of 1*0-1,1,2-
trichloroethane, i.p.
AC-1
mouse, 0.1-0.2 g of 1*0-1,1,2-
trichloroethane, i.p.







mouae, 0.1-0.2 g of 1*0-1,1,2-
trichloroethane, i.p.
                                                                                                                      AC-1
                                                                                                                      AC-1

-------
1,1,2-Tricoloroethane (continued)




                                Breach
                                              Urine
Blood
                                                                                Comments
Hef.
Other!
38Clradioactivity 2. 91 human, about 5 mg of 38Cl-l,l,2-
(l hr) tri chloroethane, inhaled in a single
breath

AC- 3



-------
TRICHLOROETHYLENE
   (TCE)
CO
                                                                            rRtCHLONOCTHYlCNC
                                                                                OMIOC
                                                 mriMuoLCCUKu «CA»IX«C;EUC»I Mooucr




4 C H Of /
CI H ^^
' \ 1
CI-C-C-OM
i i
Cl H
CI *OH
f 1
CI-C -C-M
t 1
^-^ CI OM -v^^

MlXfO fWCTlO*

° SfS





^^*v^_ C*
^ 1
CI C

CI






a
. c"

OH
                                    TfllCHLOWOCTHAMOL

                                  C/fl-» 6tVCV#OHn IRlNSffftiS
                                        CI M
                                              H 0   1IIICMIO»0€IM»I«01.
                                               * *   CLUCUAOHIOt J
                                                                                                  Proposed intermediary
                                                                                                  metabolism of TCE.   (AD-1)
                                 Breath
                                                 Urine
                                                                            Blood
                                                                                    Comment a
                                                                                                                         Ref.
Parent compound:
                                               27. 731 of
                                               retained  TCE

                                               18. 6Z of
                                               retained  TCE

                                               25.% of
                                               inhaled TCE
                                               concentrati on

                                               19. % of
                                               retained  TCE

                                               16.X of
                                               retained  TCE
human, male,  inhalation exposure,
concentration of TCE not stated
                                                                                                                           AD- 8
                                                                                   human,  female, inhalation  exposure,    AD-8
                                                                                   concentration of TCE not stated

                                                                                   human,  0.537 or 1.074 ppm  inhalation, AD-7
                                                                                   for  30  rain., at rest
                                                                                   human,  male, 27 ppm inhalation        AD-5
                                                                                   exposure,  4 hours

                                                                                   human,  male, 81 ppm inhalation        AD-5
                                                                                   exposure,  4 hours

-------
            Trichloroethylene (continued)
                                            Breach
                                                                          Blood
                                                                                             Comments
                                                                                                                                Hef.
            Parent compound (cont.)
CO
-J
                                              13.X of
                                              retained TCE

                                              19.22 of
                                              retained TCE

                                              12.7X of
                                              retained TCE

                                              10X of
                                              retained TCE
                                              8Z of
                                              retained TCE

                                              72.IX
                                              82.3X
                                                . 8X
                                                                           41.3 mgX
                                                                           (i n blood
                                                                           cellular
                                                                           components)
human, male, 201 ppm inhalation       AD-5
exposure, 4 hours

human, male, 320 ppm inhalation       AD-4
exposure, 160 min

human, female, 320 ppm inhalation     AD-4
exposure, 160 min

human, male, 70 or 140 ppm inhalation AD-6
exposure, with or without 100 W
workload, for 4 hours

human, male, 54 or 97 ppm             AD-3
inhalation exposure, 8 hours

rat, 4.0 uCi of 3"ci-trichloro-       AD-2
ethylene, by stomach tube

rat, 7.5 uCi of 38Cl-trichloro-       AD-2
ethylene, by stomach tube

rat, 8.6 uCi of 38Cl-trichloro-       AD-2
ethylene, by stomach tube

rat, 10 mg/L,  inhalation (exposure    AD-I
period not stated)

-------
            Trichloroethylene (continued)
                                            Breath
Urine
                                                                         Blood
                                                                                            Comments
                                                                                                                               Ref.
            Parent  compound (cont.)
co
co
o
           Half-life  of  parent  compound!     No  data

           Metabolites:

                trichloroetHanoi
                                                            trace  amount
 Ho data
 50Z total
 amount excret-
 ed (350 hre,
 avg. )

 45. 4X
 (3 weeks)

 32.11
 (several
 weeks)

 48.6Z of
 of retained
 TCE (6 daya)

 42.71 of
 of,retained
 TCE (6 days)

 53.1Z
 (100 hrs)
                                                                           2.5 mgZ in
                                                                           blood  plasma
No data
                                 rat,  10 mg/L,  inhalation (exposure
                                 period not stated)

                                 calf, 3 or 12  g,  oral dose,  daily
                                 for 4 or 5 days
                                                       AD-1
                                                                                                                                 AD-14
                                                                                                                                  and
                                                                                                                                 AD-15
                 humans, male and female, 500-850
                 ug/L inhalation exposure for
                 5 hours
                                                                                                                                 AD-9
                                                                                                                                 AD-10
                 humans, male and female, 1042 ug/L
                 inhalation exposure for 0 hours

                 human, male, 54 or 97 ppra inhalation  AD-3
                 exposure for 8 hours
                                                                                           human, male, 250-380 ppra  inhalation
                                                                                           exposure,  160 minutes
                                                       AD-4
                                                                                           human,  female, 250-380 ppra  inhalation AD-4
                                                                                           exposure,  160 minutes


                                                                                           human, male, 170 ppm inhalation       AD-11
                                                                                           exposure for 3 hours

-------
          Trichloroethylene (continued)
                                          Breath
Urine
                                                                        Blood
                                                                                           Comments
                                                                                                                               Ref.
          Metabolites (cont.)

              (trichloroethanol, cont.)
Co
00
 44X
 (100 hrs)
                                                          46. IX
                                                          (16 or 21
                                                          days)

                                                          25.1 mg/L
                                                          (3  ppm
                                                          exposure)
 24.9 mg/L
 (5 ppm
 exposure)
                                                          42.0 mg/L
                                                          (10 ppm
                                                          exposure)
                                                           77.3 mg/L
                                                           (25 ppra
                                                           exposure)
                                                           220.3 mg/L
                                                           (40  ppm
                                                           exposure)
human, male, 170 ppm inhalation       AD-11
exposure for 7 hours (with a
1-hour break)

human, female, 1 mg/L inhalation      AD-12
exposure for 5 hours
human, male, occupational exposure    AD-13
(8 hra/day, 6 days/week) to varioua
concentrations of TCE, specified
in parentheses

human, male, occupational exposure    AD-13
(8 hrs/day, 6 days/week) to varioua
concentrations of TCE, specified
in parentheses

human, male, occupational exposure    AD-13
(8 hrs/day, 6 days/week) to various
concentrations of TCE, specified
in parentheses

human, male, occupational exposure    AD-13
(8 hra/day, 6 days/week) to various
concentrations of TCE, specified
in parentheses

human, male, occupational exposure    AD-13
(8 Iiia/Jay, 6 days/week) to various
concentrations of TCE, specified
in parentheses

-------
              Trichloroethylene (continued)
              Metabolites  (cont.)

                  (trichloroethanol,  cont.)
                                              Breath
                                                             Urine
                                                                            plood
                                                                                              Comments
                                                                                                                                 Ref.
oo
to
                                                              256.7  mg/L
                                                              (45  ppm
                                                              exposure)
                                                              267.3  mg/L
                                                              (50  ppm
                                                              exposure)
                                                              307.7 mg/L
                                                              (60  ppm
                                                              exposure)
                                                              681.8 mg/L
                                                              (120 ppm
                                                              exposure)
                                                              973.1 rag/L
                                                              (175 ppm
                                                              exposure)
                                                                             1.7  ug/ml
                                                                             (1st exposure
                                                                             day)
                                                                             2.1  ug/ml
                                                                             (2nd exposure
                                                                             day)
human, male, occupational exposure    AD-13
(8 hrs/day, 6 days/week) to various
concentrations of TCE, specified
in parentheses

human, male, occupational exposure    AD-13
(8 hrs/day, 6 days/week) to various
concentrations of TCE, specified
in parentheses

human, male, occupational exposure    AD-13
(8 hra/day, 6 days/week) to various
concentrations of TCE, specified
in parentheses

human, male, occupational exposure    AD-13
(8 hrs/day, 6 days/week) to various
concentrations of TCE, specified
in parentheses

human, male, occupational exposure    AD-13
(8 hrs/day, 6 days/week) to various
concentrations of TCE, specified
in parentheses

human, male, 50 ppra inhalation        AD-16
exposure, 6 hrs/day for 5
days.  Trichloroethanol level
was measured daily, nonglucuronized
fraction only.  Figures represent
maximum levels attained.

human, male, 50 ppm inhalation        AD-16
exposure, 6 hrs/day for 5
days.  Trichloroethanol level
was measured daily, nonglucuronized
fraction only.  Figures represent
maximum levels attained.

-------
              Trichloroethylene (continued)
              Metabolites  (cont.)

                  (trichloroethanol,  cont.)
                                              Breath
Urine
                                                                            Blood
                                                                                               Comments
                                                                     Ref.
Co
00
CO
                2.2 ug/ml         human, mule, 50 ppn inhalation  .      AD-16
                (3rd exposure    exposure, 6 hrs/day for 5
                day)             days.  Trichloroethanol level
                                 was measured daily, nonglucuronized
                                 fraction only.  Figures represent
                                 maximum levels attained.

                2.3 ug/rnl         human, male, 50 ppm inhalation        AD-16
                (4th exposure    exposure, 6 hrs/day for 5
                day)             days.  Trichloroethanol level
                                 was measured daily, nonglucuronized
                                 fraction only.  Figures represent
                                 maximum levels attained.

                2.3 ug/ml         human, male, 50 ppm inhalation        AD-16
                (5th exposure    exposure, 6 hrs/day for 5
                day)             days.  Trichloroethanol level
                                 was measured daily, nonglucuronized
                                 fraction only.  Figures represent
                                 maximum levels attained.
                                                                             1.28-2.85 ug/ml
                                                                             (1st exposure
                                                                             day)
                                                                             1.44-2.91  ug/ml
                                                                             (2nd exposure
                                                                             day)
                                 humans,  male and female,  48 ppm       AD-17
                                 inhalation exposure,  4 hra/day
                                 for 5 days.  Blood levels of Trichloroethanol
                                 were determined daily during
                                 and after exposure.

                                 humans,  male and female,  48 ppm       AD-17
                                 inhalation exposure,  4 hrs/day
                                 for 5 days.  Blood levels of trichloroethanol
                                 were determined daily during
                                 and after exposure.

-------
               Trichloroethylene  (continued)
                                               Breath
                                                              Urine
Blood
                                                                                                Comments
                                                      Ref.
               Metabolites (cont.)

                   (trichloroethanol, cont.)
to
oo
 2.01-2.53 ug/ml
 (3rd exposure
 day)
                                                                              1.57-2.58 ug/ml
                                                                              (4th exposure
                                                                              day)
 1.97-2.87 tig/art
 (5th exposure
 day)
                                                                              0.51-2.11 ug/ml
                                                                              (iat day post-
                                                                              exposure )
                                                                              0.18-0.51 ug/ml
                                                                              (2nd day post-
                                                                              exposure)
humans, male and female, 48 ppm       AD-17
inhalation exposure, 4 lira/day
for 5 days.  Blood levels of trichloroethanol
were determined daily during
and after exposure.

humans, male and female, 48 ppm       AD-17
inhalation exposure, 4 hrs/day
Cor 5 days.  Blood levels of trichloroethanol
were determined daily during
and after exposure.

humans, male and female, 48 ppm       AD-17
inhalation exposure, 4 hrs/day
for 5 days.  Blood levels of trichloroethanol
were determined daily during
and after exposure.

humans, male and female, 48 ppm       AD-I7
inhalation exposure, 4 hrs/day
for 5 days.  Blood levels of trichloroethanol
were determined daily during
and after exposure.

humans, male and female, 48 ppm       AD-17
inhalation exposure, 4 hrs/day
for 5 days.  Blood levels of trichloroethanol
were determined daily during
and after exposure.

-------
            Trlchloroethylena  (continued)
                                             Breath
                                                            Urine
Blood
                                                                                              Comments
                                                      Ref.
            Metabolites  (cont.)

                 (trichloroethanol,  cont.)
U>
CO
C/l
 0.03-0.27 ug/ml
 (3rd day post-
 exposure )
                                                                            0.05-0.14 ug/ml
                                                                            (4th day post-
                                                                            exposure)
 0.03-0.08 ug/ml
 (5th day post-
 exposure)
                                                                            0.05 ug/ml
                                                                            (6th day post-
                                                                            exposure)
                                                                            0.03 ug/ml
                                                                            (7th day post-
                                                                            exposure )
                                                                            0.71-1.78  ug/ml
                                                                            (immediately
                                                                            after exposure)
humans, male and female, 48 ppm        AD-17
inhalation exposure, 4 hra/day
for 5 days.  Blood levels of  trichloroethanol
were determined daily during
and after exposure.

humans, male and female, 48 ppm        AD-17
inhalation exposure, 4 hrs/day
for 5 days.  Blood levels of  trichloroethanol
were determined daily during
and after exposure.

humans, male and female, 48 ppm        AD-17
inhalation exposure, 4 hra/day
for 5 days.  Blood levels of  trichloroethanol
were determined daily during
and after exposure.

humans, male and female, 48 ppu        AD-17
inhalation exposure, 4 hrs/day
for 5 days.  Blood levels of  trichloroethanol
were determined daily during
and after exposure.

humans, male and female, 48 ppm       AD-17
inhalation exposure, 4 hrs/day
for 5 days.  Blood levels of  trichloroethanol
were determined daily during
and after exposure.
                  human,  female,  40 or 44 ppm
                  inhalation exposure.  Refer to
                  reference AD-17 for additional
                  details and data.
                                      AD-17

-------
           Trichloroethylene (continued)
                                           Breath
                                                          Urine
                                                                         Blood
           Metabolites (cent.)

               (trichloroethanol, cont.)
                                                                                            Comments
                                                                                                                               Ref.
co
0.47-0.70 ug/ml
(24 hrs from
start of
exposure)

less than 0.12
ug/ml (96 hrs
from start of
exposure)

0.78-1.32 ug/ml
(immediately
after expsoure)
                                                                          0.24-0.55
                                                                          ug/ml
                                                                          (24 hrs from
                                                                          start of
                                                                          exposure)

                                                                          trace (96 hrs
                                                                          from
                                                                          start of
                                                                          exposure)

                                                                          2.0 ug/ml
                                                                          (maximum
                                                                          level attained
                                                                          during exposure)
human, female, 40 or 44 ppm
inhalation exposure.  Refer to
reference AD-17 for additional
details and data.

human, female, 40 or 44 ppm
inhalation exposure.  Refer to
reference AD-17 for additional
details and data.

human, male, 40 or 44 ppm
inhalation exposure.  Refer to
reference AD-17 for additional
details and data.

human, male, 40 or 44 ppm
inhalation exposure.  Refer to
reference AD-17 for additional
details and data.
                 human, male, 40 or 44 ppm
                 inhalation exposure.  Refer to
                 reference AD-17 for additional
                 details and data.

                 human, male, 50 ppm inhalation
                 exposure, 6 hours/day, 5 days
AD-17
                                                                                                                                 AD-17
                                                                                                                                 AD-17
                                                       AD-17
                                                                          2.5 ug/mL        human, male, inhalation
                                                                          (maximum         exposure, 12 mins/hrs, 6 hrs/
                                                                          level attained   day 5 daya
                                                                          during exposure)
                                      AD-17
                                      AD-18
                                                       AD-18

-------
          Tri cliloroethylene  (continued)
                                           Breath
Urine
Blood
                                                                                            Comments
                                                                                                                               Ref.
          Metabolites  (cont.)

               (trichloroethanol,  cont.)
CO
               trichloracetic acid
                                                           15-20Z
                                                           (4 daya)

                                                           15X


                                                           10-15X


                                                           13-25X
 19t, total
 amount ex-
 creted (387
 hrs, avg.)

 31.9*
 (3 weeka)
                                                           17.7X
                                                           (several
                                                           weeka)

                                                           32.6X
                                                           (6 daya)

                                                           A3.91
                                                           (6 daya)
                5.0 ug/al        human, male, 100 ppm inhalation       AD-18
                (maximum level   exposure, 6 hra/day, S daya
                attained during
                exposure)

                                 dog, dose and method not stated       AD-14
                  rat, oral administration, doae        AD-14
                  not stated

                  rat, 38C1-TCE, doae not stated)       AD-14
                  administered by stomach tube

                  caff, 3 or 12 g, oral, daily for      AD-14
                  4 or S daya                             and
                                                        AD-15

                  humans, male and female, 500-850      AD-9
                  ug/L inhalation exposure for
                  8 hours
                  humans, male and female,              Afi-10
                  1042 ug/L inhalation exposure
                  for 8 hours

                  humans, male, 54 or 97 ppm            AD-3
                  inhalation exposure for 8 houra
                                 humans, male, 250-380 ppm inhalation  AD-4
                                 exposure, 160 minutes
                                 humans, female, 250-380 ppm
                                 inhalation exposure, 160 minutes
                                                        AD-4

-------
           Tricbloroethylene  (continued)
                                           Breath
                                                          Urine
                                                                         Blood
                                                                                            Comments
                                                                                                                               Ref.
           Metabolites (cont,)

               (trichloroacetic acid, cont.)
U>
oo
00
21.9%
(100 hrs)

18.1Z
(100 hrs)
                                                           30.1Z
                                                           (16 or 21
                                                           days)

                                                           12.7 mg/L
                                                           (3  ppra
                                                           exposure)
                                                           20.2 rag/1.
                                                           (5 ppre
                                                           exposure)
                                                           17.6 mg/L
                                                           (10 ppm
                                                           exposure)
                                                           77.2 mg/L
                                                           (25 ppra
                                                           exposure)
human a, male, 170 ppm inhalation      AD-11
exposure for 3 hours

humans, male, 170 ppm inhalation      AD-11
.exposure for 7 hours (with a
1-hour break)

humans, female, 1 mg/L                AD-12
inhalation exposure for 5 hours
                                humans, male, occupational exposure   AD-I 3
                                (8 hrs/day, 6 days/week) to various
                                concentrations of TCE, specified in
                                parentheses
                                humane, aiaSeB occypatioGiaS exposure
                                (8 hra/
-------
       Trichloroethylene (continued)
                                       Breath
Urine
Blood
                                                                                        Comments
Ref.
       Metabolites (cont.)

            (trichloroacetic acid, cont.)
CO
Oo
 90.6 mg/L
 (40 ppm
 exposure)
                                                        138.4 mg/L
                                                        (45 ppm
                                                        expoaure)
                                                        146.4 mg/L
                                                        (50 ppro
                                                        expoaure)
                                                        155.4 mg/L
                                                        (60 ppm
                                                        expoaure)
                                                        230.1 mg/L
                                                        (120 ppm
                                                        exposure)
                                                        235.8 mg/L
                                                        (175 ppm
                                                        expoaure)
                  humana , male, occupational expoaure   AD-13
                  (8 hra/day, 6 days/week) to various
                  concentrations of TCE, specified in
                  parentheses

                  humana, male, occupational expoaure   AD-13
                  (8 hra/day, 6 days/week) to varioua
                  concentrations of TCE, specified in
                  parentheses

                  humans, male, occupational expoaure   AD-13
                  (8 hra/day, 6 days/week) to varioua
                  concentrations of TCE, specified in
                  parentheses

                  humana, male, occupational exposure   AD-13
                  (8 hrs/day, 6 days/week) to various
                  concentrations of TCE, specified in
                  parentheses

                  humans, male, occupational expoaure   AD-13
                  (8 hra/day, 6 days/week) to varioua
                  concentrations of TCE, specified in
                  parentheses

                  humans, male, occupational exposure   AD-13
                  (6 hrs/day, 6 days/week) to varioua
                  concentrations of TCE, specified in
                  parentheses

-------
         Trichloroethylene (continued)
                                         Breath
Urine
                                                                       Blood
                                                                                          Comments
                                                                                                                             Ref.
         Metabolites (cont.)

             (tri cliloroaceti c acid, cont.)
vo
O
                17 ug/ml
                (1st exposure
                day)
                                                                        30 ug/ml
                                                                        (2nd exposure
                                                                        day)
                                                                        38 og/ml
                                                                        (3rd exposure
                                                                        day)
                                                                        45 ug/ml
                                                                        (4th exposure
                                                                        day)
                                                                        52 ug/ml
                                                                        (5th exposure
                                                                        day)
                                                                        2.4 mg/100 ml
                                                                        of plasma
                                                                        (3rd day
                                                                        post-exposure)

                                                                        0.5 mg/100 ml
                                                                        of red cell
                                                                        mass (3rd day
                                                                        post-exposure)
humans, male, 50 ppm inhalation       AD-16
exposure, 6 hours/day for 5 days.
Figures represent maximum levels
attained daily in plasma.

humans, male, 50 ppm inhalation       AD-16
exposure, 6 hours/day for 5 days.
Figures represent maximum levels
attained daily in plasma.

humans, male, 50 ppm inhalation       AD-16
exposure, 6 hours/day for 5 days.
Figures represent maximum levels
attained daily in plasma.

humans, male, 50 ppm inhalation       AD-16
exposure, 6 hours/day for 5 days.
Figures represent maximum levels
attained daily in plasma.

humans, male, 50 ppm inhalation       AD-16
exposure, 6 hours/day for 5 days.
Figures represent maximum levels
attained daily in plasma.

humans, male and female,              AD-20
1042 ug/L inhalation exposure
for 5 hours
                                 humans, male and female,              AD-20
                                 1042 ug/L inhalation exposure
                                 for 5 hours

-------
Trichloroethylene (continued)
                                Breath
                                               Urine
                                                              Blood
                                                                                 Comments
                                                                     Ref.
Metabolites (cont.)

    (trichloroacetic acid, cont.)
    monochloroacetic acid
    total trichloro-compounds
5-8Z
(4 days)

4Z
                                                total amount
                                                excreted  (112
                                                bra. av g.)
                                                 39.4 rog/L
                                                 (3  ppm
                                                 exposure)
                                                 45.6 mg/L
                                                 (5  ppm
                                                 exposure)
                                                 60.5 mg/L
                                                 (10 ppm
                                                 exposure)
dog, doae and method not stated       AD-14
                                                                                rat,  inhalation  exposure,  dose  not     AD-14
                                                                                stated
                                                                                calf,  3 or  12 g,  oral  dose,  daily
                                                                                for 4  or  5  days
                                humans, male, occupational exposure
                                (8 lira/day, 6 days/week) to various
                                concentration;) of TCE, specified in
                                parentheses
                                                                      AD-14
                                                                        and
                                                                      AD-15
                                humans, male and female, 500-850      AD-9
                                ug/L inhalation exposure for 0
                                hours
                                humans, male, occupational exposure   AD-13
                                (8 lira/day, 6 days/week) to various
                                concentrations of TCE, specified in
                                parentheses

                                humans, male, occupational exposure   AD-13
                                (8 lira/day, 6 days/week) to various
                                concentrations of TCE, specified in
                                parentheses
                                      AD-13

-------
       Trichloroethylene  (continued)
                                       Breath
                                                      Urine
                                                                     Blood
                                                                                        Comments
                                                                                                                           Ref.
       Metabolites  (cont.)

            (total trichloro-compounds,
            cont.)
VD
to
                                                        16/1.3 mg/L
                                                        (25 ppra
                                                        exposure)
                                                       324.9 mg/L
                                                       (40 ppra
                                                       exposure)
399.0 rag/I,
(45 ppra
exposure)
                                                       418.9 rag/L
                                                       (50 ppm
                                                       exposure)
                                                       468.0 mg/L
                                                       (60 ppm
                                                       exposure)
                                                       915.3 mg/L
                                                       (120 ppm
                                                       exposure)
humans, male, occupational exposure   AD-13
(8 hrs/day, 6 days/week) to various
concentrations of TCE, specified in
parentheses

humans, male, occupational exposure   AD-13
(8 hrs/day, 6 days/week) to various
concentrations of TCE, specified in
parentheses

humans, male, occupational exposure   AD-13
(8 hrs/day, 6 days/week) to various
concentrations of TCE, specified in
parentheses

humans', male, occupational exposure   AD-13
(8 hrs/day, 6 days/week) to various
concentrations of TCE, specified in
parentheses

humans, male, occupational exposure   AD-13
(8 hrs/day, 6 days/week) to various
concentrations of TCE, specified in
parentheses

humans, male, occupational- exposure   AD-13
(8 hrs/day, 6 days/week) to various
concentrations of TCE, specified in
parentheses

-------
      Trichloroetliylene (continued)
                                      Breach
                                                      Urine
                                                                     Blood
                                                                                        Comments
                                                                                                                           Ref.
      Half-life of metabolites!

           trichloroethanol
           trichloroacetic acid
Co
vr>
CO
           monochloroacetic  acid
              24 hours
              in 1st phase
              of excretion
              (first 3-4 days)

              40 hours
              in 2nd phase
              of excretion
              (second 7-9 days)

              50 hours
              in 1st phase
              of excretion
              (first 5 days)

              70 hours
              in 2nd phase
              of excretion
              (second 14 daya)

              15 hours
              (total period
              of excretion
              waa 112 hours,
              avg. )
                                                                                       humans,  male and female, 500-850      AD-9
                                                                                       ug/L inhalation exposure for
                                                                                       8  hours
                                                                                       humans,  male and  female,  500-850      AD-9
                                                                                       ug/L inhalation exposure  for
                                                                                       8  hours
                                                                                       humans, male  and  female,  500-850      AD-9
                                                                                       ug/L  inhalation exposure  for
                                                                                       8  hours
                                                                                       humans, male  and  female,  500-850       AD-9
                                                                                       ug/L  inhalation exposure  for
                                                                                       8  hours
                                                                                       humans, male  and  female,  500-850       AD-9
                                                                                       ug/L  inhalation exposure  for
                                                                                       8  hours
       Metabolite conjugates:
No data
              No data
                             No data

-------
References for Appendix




        A and B
        394

-------
                                 REFERENCES


A-l.    Bray, H.G.,  S.P.  James  and  W.V.  Thorpe.   1958.   Metabolism of  some
       omega-halogenoalkyl  benzenes  and  related alcohols  in  the rabbit.
       Biocfaen. J.  70:  570-579.

B-l.    Bray, H.G.,  S.P.  James,  and W.V.  Thorpe.   1958.   Metabolism of  some
       w-halogenoalkylbenzenes   and   related   alcohols   in   the  rabbit.
       Biocfaem. J.  70:  570-579.

B-2.    Bray, H.G.,  T.S.  Franklin,  and S.P.  James.   1959.  The formation of
       mercapturic  acids:  3.   N-acetylation of  S-substituted  cysteines in
       the rabbit, rat and guinea pig.  Biochem.  J.   73:  465-473.

C-l.    Williams,  R.T.   1959.   Chap.   8.    The  metabolism  of  halogenated
       aromatic   hydrocarbons.    In:    Detoxieation  Mechanisms.   2nd  ed.
       Chapman and Hall, Ltd. London,  pp. 237-277.

C-2.    Azouz,  W.M.,  D.7.  Parke and  R.T.  Williams.   1952.   Fluorofaenzene.
       Spectrophotometric  determination  of  the   elimination  of  unchanged
       halobenzenes by  rabbits.  A comparison  of the oxidation  in vivo of
       fluorobenzene and of benzene.   Biochem.  J.  50:  702-706.

C-3.    Spencer,  B.  and  R.T.  Williams.   1950.    Metabolism  of halogenoben-
       zenes.  A comparison  of the glucuronic  acid, ethereal  sulfate and
       mercapturic  acid conjugations  of  chloro-,  bromo-  and iodobenzenes
       and of  the o—,  m-  and p-chlorophenols.    Biosynthesis of  o-,  m- and
       p-chlorophenylglucuronides.  Biocfaem  J.  47: 279-84.

C-4.    Azouz, W.M., D.V. Parke  and  R.T.  Williams.  1953.   The determination
       of  catechols in  urine  and  the  formation of catechols  in rabbits
       receiving  halogenobenzenes  and other compounds.   Dihydroxylation _i£
       vivo.  Biochem J.  55(1):  146-51.

C-5.    Ruzo, L.O.,  S.  Safe,  and 0. Hutzinger.   1976.  Metabolism of bromo-
       benzene in the rabbit.   J. Agric. Food Chem.   24(2):  291-293.

C-6.    Zampaglione, N.,  D.J.  Jollow,  J.R..  Mitchell, B.  Stripp,  M. Hamrick.
       and  J.R.   Gillette. .  1973.   Role   of detoxifying  enzymes  in bromo-
       benzene-induced liver  necrosis.  J.  Pharmacol Exp.  Therap.  187(1):
       218-227.

C-7.    Jollow,  D.J.,  and C.   Smith.   1977.   Chapter  4,   Biochemical aspects
       of  toxic  metabolites:   formation,  detoxication  and  covalent  bind-
       ing.  In:  Proceedings of the  International Conference on  Biological
       Reactions and Intermediates,  pp. 42-59.

C-8.    Reid, W.P.,  B.  Christie,  G.  Krishina,  J.R.   Mitchell,  J.  Moskowitz
       and  B.B.  Brodie.    1971.    Bromobenzene metabolism   and  hepatic
       necrosis.  Pharmacol.   6:  41-55.
                                  395

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H-2.    Smith, J,N.,  B.  Spencer,  and R.T. Williams.   1950.   The metabolism
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                                  399

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                                   402

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       organic  solvents  in  man.   Benzene,  toluene,  n-hexane,  trichloro-
       ethylene,  acetone,   ethyl  acetate  and  ethly  alcohol.   Int.   Arch.
       Arbeitsemd.   32:  85-91.

AD-9.   Soucek,  B.  and D.  Vlachova.   1960.   Excretion of trichloroethylene
       metabolites  in human urine.  Brit.  J.  Med.   17:   60-64.

AD-10. Bartonicek,  V.   19'62.   Metabolism   and excretion  of   trichloreo-
       ethylene after  inhalation by  human subjects.    Brit.  J.  Indus.  Med.
       19(2):  134-141.

AD-11. Ogata,  M.,  Y.   TAkatsuka  and  T.  Katsumaro.   1971.   Excretion  of
       organic  chlorine  compounds  in  the  urine  of  persons  exposed  to
       vapours of  trichloroethylene and tetrachloroethylene.   Brit. J.  Ind.
       Med.   28(4):  386-391.

AD-12. Bartonicek,  V.   and   J.  Teisinger.    1962.    Effect   of  cetraethyl
       thiuram  disulphide   (disulfiram)  on metabolism of trichloroethylene
       in man.  Brit. J. Ind. Med.   19:   216-221.

                                   403

-------
Table B-2.  METABOLISM SUMMARIES FOR SOME PESTICIDES TO BE
                  MONITORED IN THIS STUDY
                           .404

-------
                                                              R2CHCC13
                                     R2CHCHC1

                                        DDT
         R2CHCHC12-
          ODD
I (TD2)
DDE
                                                     R  CI1CI10

                                                       DDA

        "Metabolism of Pesticides",  C.  M.  Menzie, USDI, Special Scientific Report — Wildlife No. 127, July 1969.
                           Breath
 Urine
  Blood
             Comments
Reference
o
Ul
        Parent compound
                          In humans, environmentally
                                    exposed
                          DDE + DDT = 95% in fat
                                       5% in all other
                                          tissues
                                                                                                       BA-1
         Half-life of
        parent compound    No Data
No Data
 No Data

-------
-p-
o
       DDT  (continued)
                        Breath
 Urine
Blood
Comments
Reference
       Metabolites:
            DDE
            DDA (free
         or conjugate

            ODD
Present
                               Tissue
                           Feces, bile of
                               mammals
         Feces of mammals

          Tissue, Feces
           of mammals
                                                                                         BA-2
                      BA-2
                                                                                         BA-3

-------
Atrazine
HNXr/VH %^7xV •"
2 * \t lp^ ^Et
Deisopropylatrazine Atrazine
Breath Urine Blood
Parent Major
Half-life of <24 hr
parent compound
Metabolites:
All (including
parent <0.1 65.5 No Data


Diethylatrazlne Minor

Deethylatrazine Major
Deisopropylatrazine Minor
N'^NX^NH0
/ 2
i-.pr
Deethylatrazine
Comments Reference
Pig BE-1
Pig
BE-1


Feces = 20.3% rat, total
excretion to 72 hr-post
dose BE-2
Pig (with respect to
parent) BE-1
Rat BE-1, BE-3
Rat BE-1, BE-3

-------
        Aldrin
                                                                                                        Conjugates
                   Aldrin
                                                 Dieldrin
                              6,7-trans-dihydroxy-
                                  dihydroaldrin
                                  (aldrindiol)
                              Breath
 Urine
 Blood
                                                                              Comments
                          Reference
o
00
Parent
  Half-life of
parent compound

  Metabolites:

  All
  Dieldrin

  Aldrindiol
  Aldrindiol
  Aldrindiol diacetal
  Dieldrin
                              No Data
                              No Data
No Data
No Data
                                                43%     I
                                                 3%
                                                14%
                                         Observed only 3-4
                                          weeks post-dose
No Data
No Data
Readily Metabolized
in mammals, Poultry
                                   99.5% found in all
                                    excretion modes

                                  Major Metabolites in
                                      most studies
                                     Rats, intravenous
                                         injection
                                                                                                              BC-1
                                                                                                              BC-2
                                               BC-1
                                               BC-1
                                               BC-1
                                               BC-1

                                               BC-1

-------
       Dleldrln
o
Cl JC1
Cl "*tf



ci-^T >
-------
Heptachlor
\ / N ^
\JX /)
ci -r~"{ y— "
/ss^ci ci
Cl
Heptachlor
Breath Urine Blood
Parent 000
Half-life of
parent compound
Metabolites:
Heptachlor expoxide No Data No Data No Data


/j r^
f\JS
r^
Cl

Heptachlor epoxide
Continents
All metabolized
All metabolized in
144 hr in rabbits

Only metabolites in
animals , flies ,
plants, and soil






Reference
BB-1

BB-1



BB-1

-------
References
BA-1      Shaper, M.  L.  and  J.  E.  Campbell,  Distribution of Pesticide Residues
         in Human Body  Tissues from Montgomery County,  OH,  in "Organic  Pesti-
         cides in the Environment",  by A. H.  Rosen and  H.  F.  Kraybill,
         Advances in Chemistry Series,  No.  60,  American Chemical  Society,
         Washington, pp.  89-98,  1966.
BA-2      Matsumura,  F. ,  "Toxicology of Insecticides", Plenum  Press,  New
         York, 1975.
BA-3      Menzie, C.  M.,  "Metabolism of Pesticides",  Dept.  Interior,  Bureau
         of Sport Fisheries and Wildlife Special Scientific Report No.  127,
         July, 1969.
BB-1      Menzie, C.  M. ,  "Metabolism of Pesticides",  Dept.  Interior,  Bureau
         of Sport Fisheries and Wildlife Special Scientific Report No.  127,
         July, 1969.
BC-1      Menzie, C.  M.,  "Metabolism of Pesticides",  Dept.  Interior,  Bureau
         of Sport Fisheries and Wildlife Special Scientific Report No.  127,
         July, 1969.
BC-2      Matsumura,  F. ,  "Toxicology of Insecticides1', Plenum  Press,  New
         York, 1975.
BD-1      Menzie, C.  M. ,  "Metabolism of Pesticides",  Dept.  Interior,  Bureau
         of Sport Fisheries and Wildlife Special Scientific Report No.  127,
         July, 1969.
BD-2      Shaper, M.  L.  and  J.  E.  Campbell,  Distribution of Pesticide Resi-
        ' dues in Human  Body Tissues from Montgomery  County, OH, in "Organic
         Pesticides  in  the  Environment",  by A.  H.  Rosen and H. F.  Kraybill,
         Advances in Chemistry Series,  No.  60,  American Chemical  Society,
         Washington, pp.  89-98,  1966.
BE-1      Erickson, M. D., "Studies  in  Analytical Chemistry",  Ph.D. Thesis,
         Univ. Iowa, Iowa City,  1976.
BE-2      Bakke, J. E.,  J. D. Larson and L.  E.  Price, J.  Agr.  Food Chem.,
         16, 698 (1968).
BE-3      Larson, G.  L.  and  J.  E.  Bakke,  J.  Agr.  Food Chem., 23, 388  (1975).
                                     411

-------
                            APPENDIX C




                    Wind Roses for.Study Sites
Note:




     The length of each line indicates the frequency  of wind  from  this"




direction.  The width corresponds to the wind velocity.   From narrow-




to wide, the division are:  1-3 kts, 4-6 kts, 7-10  kts, 11-16 kts,




17-21 kts and > 22 kts.
                                412

-------
                                       N
          3. ex
                      -*.
   3.3X
                                 O .EX
H.e>
  3 .ex
      3.3*
           2. e*
                               «. a>
                       e.
                Q .
                                                   1 0
                                        i  i i
                                        SCALE CJO
 Figure Cl.  Wind rose for Baton Rouge, LA.

-------
                                               N
                                        . 4X
! !
             7 .
                                             0             10
                                              f i i i i i t t  i i f

                                               SCALE:
      Figure C2.   Wind rose for Newark, NJ.

-------
-p-
H
Ln
                                                                            N
                                                    e.
                                            S . 7*
                               7. EX
                        10.2X
                                           6.
                                                          3.BX



                                                              3. IX
r
                                                                 2.6*
                                                        v

                                                         J^.
  V
                                                         3.3X
                                                                              t  j «  i i i t i
                                                                            SCALE:

                           Figure C3.  Wind rose  for McGuire AFB, Writestown, NJ.

-------
                                                             N
                                        4. ex
                                  3. ex
                                              . ex
                              3. ex
                                                  3. 7X
                        S. 7X
              12. 7
Ov
              I6.2X
                                                     4.0X
                                                       5.3X
                                                   3. 0X
                                                2.6X
                                             3. 7X
                        9. ex
                                e.sx
                                       9. 2
                                                            O           10
                                                            I I I I I I I I I I I

                                                             SCALE cx:>
                            Figure C4.  Wind rose for Buffalo,
NY.

-------
                                      TXT
               o .ax
         s. \x
   A .OX
4 .
    \ \ .ex
               Q.4X
                                      0             t
                                       I i ; I I  I I I I I i

                                        SCALE
     Figure C5.  Wind rose for Greensboro, NC.

-------
                                      N
7.7*  s-i*3.ex5-
                                9 .
 e.ax
5.7X
            1 2 . SX    -=C3| 4


                     *1
                   y i.sx


                     1 .7X
          s.ex
                                     0
                                      SCALE CJO
     Figure C6.  Wind rose for Winston-Salem, NC.

-------
                  7. ex
N
           4. 0X
                          4.7X
       2.2X
                                -4. 4X
                                   3. 7X
                                         6.9X
                                       6.4X
                                  6.7X
                            Q. IX
                 12.8X
i iii  t i t  i i  i
  SCALE  C*O
Figure C7.  Wind rose for Houston  (Ellington AFB),  TX.

-------
                         9.4X
                                                   N
                                B.6X
                                       G.7X
                                             6. OX
                       10. ax
                                                   I I I  I I I I I I I I
                                                    SCALE
Figure C8.   Wind rose  for Houston Intercontinental, TX.

-------
              0. -4X
                                      N
       E.esx
                           B. IX
    3.S2X
                              -*. ax
                                  7. ax
                        12 .7*
                                      I i  ii i i lift;
                                       SCALE  cJo
Figure C9.  Wind rose for Houston (Hobby), TX.

-------
                   APPENDIX D




Population Density Maps for Potential Study Sites
                      422

-------
                otit tt-nua~-rm
         PLOT CEMTER IS «T«
     LATITUDE   39.4954
     LONGITUDE   31.1831
N)
CO
RAD I
Fro*
0.00
0.50
1.00
1.50
2.00
2.50
3.00
3.50
4.00
JUADRANT
Jaclor
1
2
3
4
S
6
7
8
•9
10
11
12
13
14
IS
16
1 P<
To Ui
O.SO
1.00
1.50
2.00
2.50
3.00
3.50
4.00
5.00
TOTALS 1
Population
20432.
10170.
8268.
9796.
5677.
26.
0.
<&.
1853.
141.
3490.
4936.
31373.
25831.
21320.
16342.
3PULATIOH
ItHlA Ding
t.
2.
3757.
19087.
12995.
22185.
32940.
22109.
47182.

















CUMUlfttlv*
0.
2.
3753.
82846.
3S841.
S8026.
90966.
113075.
160257.








HUES

v.«\_
.
*.S_

I.*—

1 .5
                         3479
Orel* Sti*

• Population
6
\
...s 	 rt 1;. ...
• — *o —
4
O

/

a
O . !
                                                         \
                                                                              o o
                                                 j
                                                 I*
                                                 I
                                                E
                                                                                          P  §0d
                                          S.0.
                                                   H»p by Conput«r Hipping  Stift
Dlv.
           Figure D-l.   Population density map  for  the area surrounding Allied, North,  Baton Rouge, LA.

-------
.p-
K3
            flAP CREATED OHi ll-AUO-78   ftT> il»«3»31

            THE  PLOT CENTER IS ATI
            LATITUDE   30.4742
            LONGITUDE   91.1870
                RADII
             From
         To
                 POPULATION
                 Ulihin  Ring
Cvnutatlv«
0.00
0.50
i.e0
1.50
2.00
8.50
3.00
3.50
4.00
9.50
1.00
1.50
a. 00
8.50
3.00
3.50
4.00
5.00
75.
1300.
7376,
13991.
88717.
30853.
89618.
86174.
43724.
75.
1375.
8751.
E2743.
51459.
83312.
111930.
138104.
180928.
QUADRANT TOTALS I
Sector  Population
   1       16261.
   8       84909.
   3       10481.
           13446.
            6588.
               9.
             770.
            1865.
             189.
            8660.
            3068.
            8922.
           34176.
           81928.
 5
 6
 7
 8
 9
ie
n
la
13
14
is
16
                      83547.
                      18018.
• Population    5(4

          	'	
                                             i                     /
                                      9 • ^^^^^gam^J**^***^*•••••••••••••••••••••••••••••A*****
                                                                                                             \
                                                             Hap  by Co«pul«r flapping  Staff     |      Cen*u» Bvraav, Geography Dlv.


             Figure D-2.  Population  density  map for  the area  surrounding Allied, South,  Baton  Rouge,  LA.

-------
         •HE  PLOT CENTER IS «T«
         .ATITUDE   30.4960
         .OMQITUOC   91.1814
Ln
RADII POPULATION
Fro* To UltKln Ring

0.00

i!00
1.50
2.00
2.50
3.00

0.50
1.00
1.50
2.00
2.50
3.00
3.50
3.50 ' 4.00
4.00 5.00
tUADRANT TOTALSI
factor Population
1 17826.
2
3
4
S
6
7
8
9
10
11
12
13
14
15
16
9813.
9H6.
8232.
9099.
68.
0.
0.
1853.
923.
5776.
9422.
26982.
29868,
17947.
13184.

2.
2472.
6453.
I980«.
17936.
25132.
25906.
27514.
34924.












Cumulative

2.
2474.
8927.
28727.
46663.
71795.
97701.
125215.
160139.

Clrcl* Sit* • Population S 1 4
f V 0 /
* '
6 3
. ° 00;
0
«ar 9
O O /-^ t
. QOO o • |
QOO 0U
poYCJ >
\ J^~T^ n f ) Or
" — v^ ~ o-^-v
: (i/'"">\ v-<(i
tf


HUES
ft-Q -.,

"'** r
rtCN-^ \-S /I y^. *
111 /*^ OV f^^^ff
\j f¥^/^^r^~^'^COJ~"^
O O ^•xv j s~\ ^*"^
o +. R^a^fQ0

\fl v^ / .^^ Vw-' i
•i.*-Jn CCD^WO ^ 0 '

0 0 ^d^XVVi 0"
                              Population
                               870
                              1740

                              34
Hap by Conputcr Mapping
                                                                                             C«n*u» iur«tM, Q«Ofr«pKy Dlv.
            Figure D-3.  Population density map  for the area surrounding Ethyl Corp.,  Baton Rouge,  LA.

-------
    HAP CPE ATE 9 ONI  I1-AUG-7B   ATI I1M6US

    THE  PLOT CENTER IS ft?«
    LATITUDE    30.3179
    LONGITUDE   91.2324
to
RAPI1
from To
0.00
0.50
1.00
1.50
2.00
2.50
3.00
3.50
4.00
0.50
1.00
1.50
2.00
2-50
3.00
3.59
4.00
10.00
POPULATION
Ullhln Ring Cunul»llv«
0.
392.
1226.
1742.
2983.
3422.
8390.
- 2443.
66513.
0.
392.
1613.
3360.
6348.
9770.
12160.
14603.
161116.
                                                   Clrcl* £l«* • Population    .      I

                                                     	\	*•
QUADRANT TOTALSI
Soctor  Population
 1
 8
 3
 4
 5
 6
 7
 8
 9
10
11
12
13

IS
16
 1232.
 8803.
43295.
24196.
 1423.
 2369.
  827.
    e.
    o.
 1191.
  442.
 8347.
 4259.
 3135.
    0.
 1597.
                                          HUES
                                                                            n
                                                                            0
                                                                           0
                                                                                    °
                                                                               'O
                                                                                O
                                                                                     4-°
                                                                          n
                                                                                                          O
                                                                                                O
                        Population
                         leci
                         2i2a
                                                            /
                                                                                               O
                                                                                                       o\
                                                                 n
                                                                                                                         1*
                                                                     /                  Q,
                                               •.*.•**•*....*•••*•••»*•**,» .---••--••»«•-. *f"d** •»••-•••»"• ••••••^j^j*
                                                  flap bt| CoMpuivr Happlnj Staff    |      Can

                                                                                            Can«u* Buratu, GeogrtpKy Dtv.
             Figure  D-4.  Population  density map for  the area  surrounding Dow Chemical, Plaquemine,  LA.

-------
IMP CREATED ON*  Il-AUO-78   ATI It 144119

THE  PLOT CENTEK  IS
-ATITUDE    30.3679  '
.OHOITUDE   91.1817
RADII
from
• .00
oiso
1.00
1.50
2.00
2.50
3.00
3.50 •
4.00
0
1
1
2
2
3
3
4
to
HJADRANT
Stctor
1

3
4
5
£
7
8
9
10
11

13
14
15
16



To
.SO
.00
.so
.00
.so
.00
.so
.00
.00
TOTALS i
POPULATION
Ulthln Ring
0.
863.
0.
0.
2026.
480.
3439.
4247.
33801.

<
Cumulative |
e.
863.
963.
863.
£389.
3369.
6868.
11055.
44856.





















1









Population

















Q
3044
6103
10977
1332
2359

7315
1736
442
0
625
4352
989
0
629



4
•
*
•
•
•

*
*
•
•
*
*
*
•
•





















HUES
A A










^r

1
1
£
2
3
3
4


— .
.0 —
.s__
• 0_
• 5_^.
•0__ .
• S__
.o_^.

!
{
I
•
;
1
!
i
•Mri
1
_l

1
-H
—a
4
•Mrt
1
— {
1
	 (
i
                     3394
                                      !•.*_
                                             Clrcla Slt« • Population
                                                                  •.
                                                                  \
                                                      o
O
                                                  1ft
                                                                          O
                                                                                                        \
                                                           ti
                                                                                                  14
Mtp i>u Computer (1»pplng Stall
                                                                        tffl    [
     13
                                                                                            \
    Census Bura*u, GaograpKy Dlv.
     Figure D-5.  Population density map for the  area surrounding  Hercules, Inc.,  Plaquemine, LA.

-------
N3
CO
     4AP CREATCD ON?  Si-Al>a-78   ATI 1U34H83
     FHE  PLOT CiNTER  IS
     lATJTUDE   30.2449
     _OIIQ1TUDE   91.9980
RADII POPULATION
Pros ?JLy /
6 ^-r) 3
N 0 oo o ,

7 A
^ 2
. °
rjTO^ v.y /^\
g^^\ ^^*—r-t^
i ^ r^
4- ^>L-
3195. J'J 	 ! O
1340. ;•• 	 1 v-f /-^
S<1' 2 ~"~"3 /'-N I J '*
985! 3-«L j () \J ^ ^^"^
1750. 3.» 	 | N-/ O
v M
! / O. o \
19. « 	 	 I. 	 *A 	 	 Id 	 •- 	
                                                     Hap bg Computer Happing Staff    |     Camus Bureau,  Geography Olv.


             Figure D-6.  Population density  map for the  area surrounding Ciba-Geigy,  St.  Gabriel,  LA.

-------
                           AT a tot
THE  PLOT CENTER  IS ATI
IATITUDC    40.6520
LONGlTUt-C   74.
RADII POPULATION <
From To Ulthln Ring Cumulative* |
0.00
0.50
1.00
1.50
3.00
3.50
3.00
3.50
0.50
1 .00
1.50
3.00
3.50
3.00
3.50
4.00
640. 640.
BS3«>8. 35943.
46586. 73534.
40677. 113311. i
39343. 153454.
36596. 189&50. i
47577. 336637.
44813. 331440.
4.00 ' 5.00 204097. 485537.
QUADRANT TOTALS*
Sector
1
2
3
4
5
6
7
8
9
to
11
13
13
14
15
16







Population
.463.
4.
38676.
63139.
13669.
13046.
9403.
30134.
33139.
16137.
43881.
31471.
41379.
40553.
490B6.
S4471.












d


MILES i
i
1
&.S j

1.0 	 j

«.s
e.e 	
a.? 	
3.0
Population
»™3 0 3.5
3405 ft 	
	 S~\ 4.6 	 1
                     68161
                                             Circle Slxe • Popu(»ti->n    c      I      4
                                                      \
                                      5.«L
                                                 10
       /       O  O  ^     ©   OrWp °

                         °0   0(g^^M

                   /     40.      OO  ta
.....*..**.-............*..*».*.*....... ft^-.........*| WW.V4T...U. ................. ^ — .....	,	
 tt»p  by Cowpulcr Flipping  Sltlf    |     Conjuft  lura«u, Q«ogr«pliy Olv.
Figure D-7.  Population density map  for the area surrounding White Chemical Co., Bayonne,  NJ.

-------
    CREATED OH« li-miG-78
THE  PLOT CEIJTER IS ATI
MTJTUPE    40.8318
LOHOITUPE   74.1297
RADII
Frv»i To
9.99
0.50
1.00
1.50
2.00
2 • 50
3.00
3.50
4.00
0.50
1.00
1.50
2.00
2.50
3. 00
3.50

s!0o
POPULATION
i'ilhln Ring
2220.
17306.
38393.
59361.
698B2.
73379.
8394S.
88739.
179616.
Cunulatlve
2220.
I9S26.
57918.
117279.
183161.
E56540.
3404S8.
429227,
$93843.
                                           Circle Slsa • Population    c      I
QUADRANT TOTALS*
Sector  Population
   I       22745.
   8
   3

   S
   6
   7
   8
   9
  se
  II
  12
  13
  H
  15
  16
50639.
62377.
€5419.
27117.
24969.
28965.
46625.
69742.
79933.
50914.
15996.
 £578.
17103.
 4889.
                   Population
                    2037
                    4973

                    BUS
                                           I
                                         \
                                              oa
                                       O     o   o  o   Q

                                           °0°°oct>  £
j    °
 j    O oQcO

 i   o°o0o
                                                           8 ^o0^0
                                          Conpvlwr Napping
•cc
^•o
1
b
3
	 ~ 	 1
«^*^
o% 15
\
14
, ...... \ 	 „ 	
                                                                                                       Div.
         Figure  D-8.   Population density map for the area surrounding Givaudan Corp., Clifton, NJ.

-------
THE
frCt'lCO O»H JI-/»UC-V3


PLOT CENTER IS fit •

    -ttf.£J3?

     74.2139
                 ATI «9S«37I2J
PAOI
Froa
9.99
9.59
1.99
1.59
£.99
2.59
3.99
3.59
4.99
1UADRANT
Sector
1
2
3
4
5
£
7
8
9
19
11
12
13
14
15
16






I POPULATION
To Uithin Ring Comula
9.59 267. 267.
1.99 9. 267.
1.59 4384. 4551.
3.09 6918. 19569.
2. 59 31775. 43344.
3.90 56586. 99939.
3.59 £6734. 165664.
4.99 66109. 231773.
5.90 151673. 393446.
TOTALS!
Population
49337.
13689.
13569.
51975.
59676.
37664.
38492.
26371.
23450.
21307.
15999.
13367.
2778.
£937.
3456.
£6692.


Population
I486 n
2973 Q
.-._>S
live

















MILES
On 	
• ^taM

0.5_.

1««L.

l.5_^,
2 A
•"_•
e.s_
3.0_.

3.*
J --r*
4.0_^
            S945*
                          5.0
                               Ctrele Sis® • F-^pulaiScn   c    ^t-^  _4
                              !cP!>~ SQP
                                  • x~\0


                                 igo5-
                                 J0°
                                    0^,
                    o
                                        o
! o °n°~ O
* oo00   (
                                        CO  o
                                        /  o o
                                              o
                                                        
-------
 1«P CREflTED OH» Ii-flUG-78   ATI  ffl9H-i!04

 THE  PLOT CENTER !S AT«
 IfiTJTUl'E   40.7136
 IGNGJTUbE   74.H46
PAD I!
Prow To
o.eo
0.50
1.00
J.S0
e.eo
a. 50
3.00
3.5fl
4.00
0.50
1.00
1. 50
8.00
a. 50
3.00
3.50
4.00
S.00
POPULATION
Uitnin Ring Cvnvlative
1803. 1808.
82120. 23932.
16600. 4P52a.
9S98. S0130.
51258. 101348.
99474. aoossa.
171574. 372396.
175946. 543342.
304796. 853138.
                                              Circle Sis* • Popvlatlcn    g      1      4
OUflDRftHT TOTrtLSl
Sector  Population
   1
   2
   3
   4
   5
   €
   7
   8
   9
  10
  11
  18
  13
  14
  IS
  16
 85560.
  1365.
  3520,
 30236.
 74985.
100918.
181592.
141621.
 73344,
 36473.
 12578.
    40.
 37545.;
 89870.
 89141.
 74450,
                     Population
                     17*3
                     681*
                                       5.0.
                                                H»p by Computer flopping  Staff     |     Census Bureau,  Geography  Dlv
        Figure D-10.   Population  density map  for the area  surrounding Prentiss Drug  and Chem. Co.,  Newark,  NJ.

-------
     Ptor cctircK is
     UDf   40.7166
LONGITUDE   74.1440
    RADII
 Fr«»
 To
POPULATION
lathi* Ring
                                    Circle Six* • Populttifrn
0.00
o.so
1.00
l.SO
2.00
2.50
3.00
3. SO
4.00
0.50
1.00
1.50
2.00
2.50
3.00
3.50
4.00
5.00
1B02.
22120.
16600.
9598.
45926.
105299.
170609.
178860.
305760.
1802.
23922.
40522.
50120.
96046.
£01345.
371954.
S50814.
656514.
QUADRANT TOTALS"
S«ctor  .Population
   2
   3
   4
   5
   fi
   7
   ff
   0
  10
  II
  12
  13
  H
  IS
  Ifi
'8685-1.
  3118.
  IOSS.
 30129.
164551.
I158S2.
HB770.
 73244.
 36473.
 12578.
    40.
 39194.
 2B221.
 33413.
 70178.
                     681C
                                       5.0
                                       M»p by  Computar flipping Staff
                                                                                      Ceniui Buraku, G«oyr*pKy Dl%/.
            Figure D-ll.   Population density map  for the area  surrounding  Troy Chem.  Co.,  Newark,  NJ.

-------
 IrtP CPEAtED

 'HE
               I9-AUQ-78   AT«
    PtOT CENTER IS AT*
          40.7f06
.OflCITUDE   7
   RADII
          To
                POPULATION
                Ulihln Ring
 Cuautvtiv*
                Circle
0.50
1.00
  50

  50
  00

 .00
         50
 00
 50
 00

.00
.00
                     II.
                      0.
                    608.
                  11898.
                  6S484.
                 I0S452.
                 HUSO.
                 189177.
                 303656.
•UftDRANT TOTfllft
(•clor  Population

  8
  3
  5
  6
  7
  8
  9
 te
 11
 la
 13
 H
 15
 16
          18469.
           3308.
          29304.
          48331.
          62257.
          97884.
          95367.
          56407.
             42.
           5933.
          €5815.
          64B49.
          83631 .
          79795.
    It.
    11.
   €19.
 12517,
 76001.
1334S3.
324633.
S13810.
B17466.
                    Population
                    1703  o
                    3405  Q
                    681»
                                             1                    ./.	.,
                                               H»p by Coapvlar flipping Sl«ff
                                                                                      C«niuj Bureau,  G*ogr«ph|; Olv.
         Figure D-12.   Population density map  for the area surrounding Standard  Chlorine Chem.  Co., Kearney, NJ.

-------
   fM£  PLOT  CCIITCP  IS <»T«
   -ATITU&E    40.6302
   .OMGITUDE   74.0887
LO
Ln
PADI
Fro*
4.00
0.50
1.00
1.5d
e.e0
a.s&
3.60
3.50
4.60
1U ADR ANT
Sector
i
2
3
4
5
£
7
8 *
9
16
11
12
13
14
IS
16
I POPULATION
To Ultktn Ring
d.50 936.
1.00 1S134.
1.50 20639.
2.00 23069.
2.S0 32201.
3.00 67054.
3.50 61870.
4.00 83194.
5.00 265763.
TOTALSl
Population
20941.
37094.
22749.
46004.
44036.
68666.
59640.
3301S.
47096.
62521.
£9757.
120.
2261.
25171.
41843.
E89S3.
Cu*ul*llv«
936.
16070.
36699.
59788.
91989.
159043.
22Q913.
304107.
56987S.

,







NILE
«.A
* *«

0-5.

I.OL

1.5
                                                Clrcl
                       Population
                        1182
                        8364
                                                   M»p by Computar flapping
Consul Bureau, Geogrkphy Olv.
             Figure D-13.   Population density map for  the  area surrounding  UOP, East Rutherford, NJ.

-------
U)
                                                                                   27.01
                                                                                 tteatfield
                                                                                  own
                                             NIAGARA
        Figure D-14.  Census tract map for  the portion o£ Niagara Falls, HY, surrounding "Old  Love" Canal.

-------
       Table  D-l.   CENSUS DATA FOR  TRACTS  SHOWN IN FIGURE  D-14
 ToWtl Clonictirutiu *l Howling Unhi tni Populotwa, bf ll«ki:'.1970-Con.
                                                                               T, H.T.
•t«c*t

WMufl
Imrti

 s —
 ^•TIT

 SEE

 jtr ^
                                                        ...  .„



                                                        *"
                                        .

                                     ,   .  4.
                                           u tjoaa


                                        I   U WRD
                                           U iuao
                                        .   U IfHB


                                        .  • >• wa
                              S  :
'y  it '"
T  il »<4
_. JJt IU
 . JA n


 ^  u '
 ..  4* n-

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 .  U ••

":  w M
 •  •
 1 —1? M


 :  B I
                                                              Ti
                                    •   .  u tnm
                                    H  _  S «.
                                    •   .41 !••

                                    «   -  U >M>
                                    •     u tn»
                                    •   .  C u»
                                          '
HOa STATISTICS
                                                            ItfTALO
                                                                         ItU
                              Reproduced  from

                              best available  copy.
                                     -437

-------
     HAP CREATED ONI H-AUO-7S   AT(  IH28I07

     THE PLOT CENTER IS «T«
     LATITUDE   29.7010
     LONGITUC-E   95.2564
LO
CD
RADII
Fro« To
9.00
0.50
1.00
1.50
£.00
a. 50
3.00
3.50
4.00
0.50
1.00
1.50
a. 00
a. 50
3.00
3.50
4.00
5.00
POPULATION
Ulthln Ring Cuawtatav*
0.
5689.
15055.
18108.
22030.
43830.
39264.
39805.
103895.
0.
6689.
£0744.
36846.
60976.
104706.
133970.
173775.
877670.
                                                Circle Sis* • Population    .     I      4
OUADRAHT TOTALSI
Sector  Population
   1       17599.
   a          94.
  , 3        £263.
   4       18104.
  ' 5       13485.
   6       16143.
   7       ESSia.
   8   '    80734.
  , 9       19669.
  10       85414.
  II       10191.
  12       11393.
  13       158B8.
  14       20198.
  IS       85283.
  16       28701,
                                                                          o
                                                                              QrCCboo
j - » °DO C
: 	 _ 	 / 	 *^A 	 	 	 13-.
\
^4 i
i
                                              H»p by Computer (lapping Staff
                                                                                      Census Bureau,  Geography Dlv.
            Figure D-15.  Population density map for the area surrounding Petrotex,  Houston, TX.

-------
         >-7«

         "HE PLOT CCHTER IS
         .ATITUDC   39.7405
         .OHGtTUDE   9S.1694
VO
RADII POPULATION
From To Uitkln King Cui»ul«Uv«

o.ee
o.se
i.eo
i.se
e.ce
2.se
3.00 '
3.50
4.«0
UJADRANT
factor
1
2
3
4
S
6
7.
8
9
40
11
d2
113
14
15
16







0.50
i.eo
l.SO
2.00
2. SO
3.00
3. SO
4.00
S.«0
TOTALS l
Population
74.
3096.
4716.
7716.
9924.
S14S.
10699.
8380.
8279.
5705.
203S1.
24316.
19327.
1944.
0.
122.







e. e.
0. 0.
231. 281.
763. 934. '
8462. 0446.
21691, 31137.
25243. 56380.
27918. 8429B.
45496. 129794.




f

Eirela Sic* • Population S i 4
\ O /

6 3

0 0 ^ ' '
7 ° O O® O (J 2 . !
OoAnfP i
0 Vy©CJ^ 0 o0
.^1 J X^v V- r -» \J ^.l

/^*\/^vLj ^^ r) x^ i
l°l~I^ ^— ' ^^^ V-JL !
v^/ v_/ !
i
o !
HUES j O j
•*•« — OOoo o + [
%— r^—s*-' j
«.s 	 j o^ .
O A
1-0 J . • 0
~1
I
1.* 	 i
2. ft
"
oO° ^
_.^* x^ .^^ _.^
r»Qo r* r\ Q ^
2.5. — , O^HQ,Ty O l6
Wo" 36 1 ooOp, V) O
2358 A 3-s — i x o /MQ@O cr^ \ !
^^*Vy 4 $ ' ^"^ V X '
4716O ' j l! r>CP /~\ M i
B.o 	 1 	 / 	 ,:r. 	 ©3 	 \ 	 : 	 I
                                                        H.p  b^ Cc.pul.r Happing
Consu» luretu, G«ogr»pK^ Dlv.
            Figure D-16.  Population density map for the area surrounding Ethyl Corp.,  Pasadena, TX.

-------
IAP  CREATED ONI lt-AUO-78   ATI  69 t 17807
•HE  PLOT CENTER IS
.ATITUDC   29.3569
.OflCITUDE   94.9417
   RADII
from
  59
  00
  50
  60
  50
                POPULATION
                Utthln Ring
                           Circle Sli* • Population
         .50
         .CO
         ,50

         50
         00
         S0
 lies.
 2053.
 5570.
13350.
 5635.
16327.
 3689.
       5.00

        TOTALSI
Sector  Population
   1        S92«.
   Z       21387.
   3        4876.
   4       22325.
   5        4047.
   6         862.
   7         422.
   8         171.
                   2539.
 1105.
 3153.
 6728.
22073.
27713.
52729.
S7471.
£0010.
                    Population
                     867
                    1735

                    3469
                                     nuts   jr)
                                      e.o	1^--'
                                               M»p by Co«put«r flapping  SttH
                                                                                                                  1
                                                                                     Census Bureau* Geography DJ*'«
       Figure D-17.  Population density map for the  area surrounding Gulf Chemical,  Texas City,  TX.

-------
MAP CPCftTCD OH»  I1-AUO-7C   AT* IJ«ES«3»

THE  PLOT CENTER IS Alt
LATITUDE    29.3783
LONGITUDE   94.9444
RADII POPULATION
From To Ulthlh Ring
0.00
0.50
1.00
1.50
2.00
2.50
3.00
3.50 .
4.00

QUADRANT
Sector
1
2
3
4
S
6
7
8*
9
10
la
14
15
16
0.50
1.00
1.50
2.00
2.50
3.00
3.50
4.00
S.OO

TOTALS 1
Population
4393.
11842.
6449.
5639.
852.
2£1.
3046.
13790.
6541.
4900.
1817.
422!
171.
0.
«.
3916.
S231.
5275.
16831.
8427.
10628.
1203.
S762.













Cumulative
«.
3916.
12147.
17422.
34253.
Clrcl* Sic* • Population i; 1 4
r 	 v 	 * 	 	 / 	 }
\ /
6 3 !
1
„ i
v * / i
4E680. x ' :
53308. •
54511. •» O 9 •
60273. 7 ^ 2 S
! 1
0 O /?lPo J
»^^ 11 A»— ^ /T^ 11 **^ \
i ^—^ *>~~s f\ ^-^ '
s** * /^\ 9O " I
£
MII rc
* A

r\ S~\ /^Y-* XV ° rS
0 O-o o 9°ft°°^5
0 X"^k ^1 1 S^*.f~\ ^^^ '
( 1 * ^^i^vJ^-^ | * . !
V_«X v^'^ *T" P
d'5 — i r^ ° Q noO i
l .ft A {_) \LS {-s tX
i n 1
1.5 	 1 0 U •
                    PODtlUtlOft
                     3469
                                                                      0
                                                 ,.
                                                                                                           IS
                                                           11
                                                                                            \
                                               M»p bg Computer  Flapping Staff
Camus Bureau, Gaogrftphy Dlv.
       Figure  D-18.   Population density map for  the area surrounding  Union Carbide,  Texas City, TX.

-------
                 ONI  SS-MJOl-78   ATI'
     tm,  PLOT CENTER  IS ftfe
     LATITUDE    2
     .OH01TUDE
M
RADII
Fro«» To
9.00
0.50 .
1.00
1.50
e.oo
e.se
3.00
3.50.
4.00
JUADRANT
Sector
1
8
• 3
> 4
5
6
7
8
9
10
11
18
13
14
15
16







0.50
1.00
1.50
a. 00
2.50
3.69
3.50
4.*0
5.00
TOTALSl
POPULATION ClreU Slie • Population c 1 .
WllKln Rl«fl CuauUtlve , 	 	 	 .?.. 	 1 	 * 	
o. e.
13. 13.
0. 13.
8516. 2529.
1866. 4395.
5167. 9568.
8999. 18561.
7318. 19B73.
| .^06,
V /
1
i
1
^ /
0
1 « x~s. ^
80388. 40255. • X--X {J K

\ ^ U _O
Population S V^ ( \ s~\
1858.
18281.
1753.
1634.
4069.
33.
106.
«.
6942.
1955.
669.
1305.
5095.
1549.
593.
B.







i—> ^ ^^r\-^\j^
rv-x owrr/
i ^CL ^^Ov^
} Si MJ
A \J
I °
j
HUES J
ft-ft » _1_
I 1
<*-^ [ ^^^
!-°-HO o
t.s j ^^ ^^
a. ft
a.s
3.0
PODHUIiOM -—
«8 Q 3.5
1863 Q -"—"
2526 rS 4*9 	
V J
v — X
5.«___
- ° . ©O o
™ ^i«^ ^
O
\_X 0.
", ° 0 °. S
0
:i "
O .
	 L 	 » 	 ,. 	 A 	




1



—
6








                                                    	-	•'	frg-	|"»«	10	•	
                                                    I1»p  by Computer (lapping Stiff    |     Cnnsus iur«*u.  Geography Di>/.
              Figure D-19.   Population density map  for the area surrounding  DuPont, LaPorte, XX.

-------
rmr- COTC/tTCD OH* 1I-AUO-7B

THE  PLOT CENTER IS AT*
LATITUDE   29.7196
LOHOlTUf'E   OS.6870
                           ATf «1>17IIS
RADII POPULATION
from To Ulthlit Rlftfl
«.ee
e.se
i.0e
t.se
2.00
2.50
3.00
3.50
4.00'

QUADRANT
Soclor
1
a
3
4
S
6
7
8-
9
10
11
12
13
14
IS
16
O.SO
1.00
1.50
2.00
2.50
3.00
3. SO
4 .00
5.00

TOTALS l
PopuUtloM
1816.
1834.
4080.
911.
1364.
1935.
0.
57.
8833.
7639.
100B3.
968.
942.
1552.
taoa.
102.
0.
0.
0.
167.
59.
9849.
1008.
1481.
31380.















Circle Slia • P«pulattoit e 1 .
CuouUiiv* , 	 -• 	 : 	 5 	 1 	 »....?. 	
n
*.
0.
0.
167.
226.
10075.
\ . /
6 o *> O 3
X** f^.
\ o °0o /
11083. /^\
12564.
43944.





\^J n
v— /~>V 8
V.X 1

!
"^"^ • ^*'>
• |
I
j
I . 0
t
"iTLJ • Q
* * 3 i H i -4- *-
, • i i
l
— jh~ * i
i.a _ /PY ) »


                                      3.0
                     Population
                      725
                     1450

                     £899
                                                                                      O

                                                                                                           15
                                      s.a
                                                           II
o
                                                                                                  »
                                                                  /
                                                H»p  by Computer Happing  Slafl    |
         .\	
         lure»«i,
          Figure D-20.   Population density map for the area surrounding Upjohn,  LaPorte, TX.

-------
MAP
JHE  PLOT CCNTER IS ft? I
LATITUDE   29.7396
LONGITUDE   9S.U09
RADII
From To
• .00
9.50
i.ee
1.50
2.00
2. SO
3.00
3.50.
4.09


0.50
I.*S9
2.e0
2. 59
3.60
3.50
4-60
s.eo


POPULATION
Ulthln Riftf
e.
65.
95.
17.
1963.
7404.
7436.
8812.
37985.


Circle £!«• • Population - 1 <
CUHvUttvft t 	 — 	 " 	 J* 	 1 	 ?. 	
es!
160.
177.
2140.
9544.
16979.
25782.
£3667.


QUADRANT TOTALS* |
5«ctor
1
£
3
4
5
6
7
8
9
10
11
18
13
14
15
16


Population
12.'
729,
2666.
7708.
2553.
3745.
64.
5912.
1B469.:
9590.
19033.
988.
967.
0.
102.




















1


HUES
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.
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v © o x
6 ^ 3 !
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i i !
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7 j-k O 2 j

1
i
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•
t
t
ji
•
|
: t
•
-|- >—
° !

i .U
l.» —* — H-^CJ ^^x O ^i
                    P«p«l«lton
                    1179
                    8358
                                                "0
                                                             o
o
                                                     /
                                                                     O
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                                                                                           \
                                              • ••..*. v. •_...•.......•..•.«...«.»... af 4^J^%.«« .•..•!.•. ».,... J ^.••••.»•.*.•«..••......«.•«...••«.•*••.•...

                                              M»p by C<«pul«r  flipping Staff    |     C«n3«f lur«*u, Googr»phtj Dlv.
      Figure D-21.  Population density map  for  the are'a surrounding Diamond Shamrock,  Deer Park, TX.

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inr CttCMTCD ONI I1-AUO-7B

•HE  PLOT CENTER IS ATI
.AT1TUDE   29.7305
.OHG1TUDE   OS.t»95a
                           «T«  II a IBIS*
Hf
from
o.eo
ft. SO
1.00
1.50
2.00
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3.00
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1.00
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2.50
3.00
3. SO
.4.00
5.00
POPULATION
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0.
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SS.
4.
171.
1964.
8765.
3475.
32674.
Cu.«UVlv.
0.
65.
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124.
29?.
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11024.
14499.
47173.
                                             Clrcl* Stt»  • PopuUlton    g      I
JUADRANT TOTALS!
factor  Poputttlon
            956.
           5837.
            603.
            329.
           4898.
           6186.
             15.
             57.
           3571.
          10632.
           •4B43.
           £989.
   I
   2
   3
   4
   5
   6
  10
  It:
  12
  14
  IS
  16
                                                                      0
                                                     \
O
                                                                            O
                                                                          o
                                                                                            0
                                                                                                      /
                                                               o   °0o
                                                                                                     O
                                           O
            894...
            102.
              0.
                                                                          *
                                                                              _l_
                                                               o
                    Population
                     1179
                     2358
                                                    !»
                                                    j

                                                   d>
                                                   16
                                                    i

M»p
^ O
" °
b\j CcMput^r napping 5l«l(
0
1
IS
X !
14 i
,a X
Cen*u* lur«»u, G«ogr»pKg Dlw.
         Figure D-22.  Population density map for the area'surrounding Rollins Environmental, Deer Park,  TX.

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