NALED


     Pesticide Registration Standard

                 (034401)
                June 1983

Office of Pesticides and Toxic Substances
     Environmental Protection Agency
             401 M Street, SW
           Washington, DC 20460

-------
II  REGULATORY POSITION AND RATIONALE



A. INTRODUCTION



This Registration Standard describes the regulatory posi-


tion of the Environmental Protection Agency (the Agency)


on registered manufacturing-use products (MPs) containing


the insecticide-acaricide, naled.  The Agency's position


is based on a consideration of available data for all cur-


rently registered uses and registered MPs with naled as the


sole active ingredient.  This position is based on a number
                       •»

of considerations.  The Standard considers labeling require-


ments , tolerances, "Special Local Need" registrations author-


ized by FIFRA Section 24(c), as well as Federal registration


granted or pending under FIFRA Section 3.  Finally, the


Agency sets forth the data requirements that must be met to


register products covered by this document.



This Standard only addresses registration requirements for


current or substantially similar future MPs and their inter-


mediaries.  Naled MPs that differ appreciably from those


described here may require amendments to the Standard.



B.  CHEMICAL DESCRIPTION AND USE PROFILE


In the United States, naled is the American National Standards


Institute (ANSI) approved common name for a halogenated


organophosphorus insecticide-acaricide manufactured by the


Chevron Chemical Company.  The chemical name is 1,2-dibromo-


2,2-dichloroethyl dimethyl phosphate.  Other names include

-------
 Dibrom®, Ortho-Dibrom®, RE 4355, and phosphoric acid 1,2-



 dibrom-2,2-dichloroethyl dimethyl ester.  The Chemical



 Abstracts Registry (CAS) number for naled is 300-76-5, and



 the EPA chemical code number is 034401.





 Manufacturing-use naled is a light, straw-colored oily liquid



 with a slightly pungent odor.  The pure compound is a white



 low melting point solid.  The boiling point for pure naled



 is 120°C at 0.5 mm Hg and the vapor pressure is 2 x 10~4



 mm Hg at 20°C.  The empirical formula is C4H7O4PBr2Cl2



 and the molecular weight is 381.  Naled has a limited solu-



 bility in aliphatic solvents; is highly soluble in oxygenated



 solvents such as ketones and alcohols; and a low solubility



 in water.





 There are currently three registered manufacturing-use products



 consisting of the technical grade of naled (90%), and



 fifteen (15) registered end-use products containing naled



 as the sole active ingredient.  There are also currently



 eighty-five (85) products containing naled in combination



 with other pesticides.  In addition, there are twenty-six



 (26) FIFRA Section 24(c) "Special Local Need" registraions.





\Naled is a non-systemic insecticide-acaricide registered


       ^                      '
 for use on field, vegetable, and orchard crops;/livestock
      --—'       s*


 and poultry, and their surroundings; greenhouses; forest



 and wasteland; agricultural, domestic, medical, and com-



 mercial establishments; and urban and rural outdoor areas

-------
(mosquito control).  The major use sites are: fruit, nut,


vegetable, and field crops; adult mosquito control; pets,


and livestock.
Naled is formulated into dusts (4% and 6%), impregnated


materials (10%-25%), emulsifiable concentrates (2-7.2 lb/


gal and 6%-26%), soluble concentrates/liquid (2.35-14 lb/


gal,and 11.4% and 20%), and ready-to-use liquids (1.26-

                         cfe£
12.6 Ib/gal and 1%-15%).  Naled is applied on agricultural


crops by using aircraft and ground equipment including mist

                   -T|
blowers and foggers.i
                 —^J



C.  REGULATORY POSITION


                                •          ™

Based on a review and evaluation of all available data and


other relevant information on naled, the Agency had made the


following determinations:




     1. Manufacturing-use products containing naled as the


sole active ingredient may be registered for sale, distri-


bution, and reformulation into end-use products,, for use,


subject to the terms and conditions specified in this Standard.




     2.  Registrants must provide or agree to develop addi-


tional data, as specified in TABLE A and TABLE B of this


Standard, in order to maintain existing registrations or


to obtain new product registrations.


                       •*

     3.  Available data do not indicate that any of the


criteria cited in 40 CFR 162.11 (b) have been equalled or

-------
exceeded at this time.  However, gaps in the data base pre-



clude the completion of the Agency's risk assessment for



naled.





     4.  Although the Agency is unable to complete a tolerance



reassessment for naled because of a number of residue chemistry



and toxicology data gaps, the Agency has concluded, based on



available data, that no changes in present tolerances are



necessary at this time.  The Agency has also considered the



residues of inorganic bromide, resulting from the use of naled



on crops and in meat, milk, poultry and eggs, and does not



anticipate these residues to be of toxicological concern, and



no additional residue data on inorganic bromides are needed.



However, the Agency is concerned about organic brominated



metabolites of naled and its impurities.  Accordingly,



additional data on this organic bromide in plants and



animals are being requested.





D.  REGULATORY RATIONALE
The Agency has determined that it should continue to allow



the registration of products containing naled, after con-



sidering the following:





     1. Acute animal toxicity data indicate that technical



naled is in Toxicity Category I on the basis of eye irritation,



and Toxicity Category it on the basis of acute oral and dermal



effects.  Technical naled has been assigned Toxicity Category I



for acute inhalation effects, pending receipt and evaluation of

-------
a valid acute inhalation study.  Human hazard precautionary


statements associated with Toxicity Category I and Toxicity


Category II labeling [40 CFR 162.10 (h)(2)(i)] should minimize


the acute hazards associated with these routes of exposure.



     2.  Dichlorvos (DDVP), a metabolite of naled was origin-


ally referred to the Rebuttable Presumption Against Registration


(RPAR) process because scientific studies indicated that


dichlorvos was mutagenic and might cause cancer, nerve damage


and birth defects in laboratory animals.  The RPAR Decision


Document on Dichlorvos, was issued by the Agency on September


30, 1982.  In this document the Agency evaluated the available


data on dichlorvos in accordance with 40 CFR 162.11 (Criteria
                                •         *

for Determination of Unreasonable Adverse Effects) and con-


cluded that the existing evidence does not support the issuance


of an RPAR for dichlorvos and consequently, that an RPAR


for naled as a precursor of dichlorvos is also not warranted.



However, the Decision Document concluded that additional


data on carcinogenic-ity and mutagenicity are needed to complete


the risk assessment for dichlorvos.  Because the data base was


incomplete, DDVP was removed from the RPAR process and returned


to the registration process.  On March 23, 1983, the Agency


issued a Data Call-in Notice under FIFRA Section 3(c)(2)(b),


requesting data on potential mutagenic effects of dichlorvos


be submitted by March 23*, 1985.  Additionally, the Agency


will wait until the ongoing National Cancer Institute (NCI)


dichlorvos bioassay on carcinogenicity is completed (currently

-------
scheduled for completion in 1984) and evaluated prior to
determining if additional data on the carcinogenicity of
dichlorvos will be required.  Since dichlorvos is a metabolite
of naled, evaluation of these studies will be necessary
for the completion of the naled risk assessment.

     3.  No other human toxicological hazards of concern to
the Agency have been identified in studies reviewed for this
Standard.

     4.  Based on residue chemistry and toxicological consid-
erations, there is no evidence to suggest that the current
tolerances are likely to expose the public to unreasonable
adverse effects.

     5.  The Agency has, for the period 1970-1S81 (primarily
1979-1981) received reports of 55 pesticide incidents involving
naled, either as sole active ingredient or in combination
with other active ingredients.  Of these 55 incidents, 40
involved definite or possible human exposure.  In at least 9
of these cases there was a physician's diagnosis of pesticide
poisoning.  In 26 incidents there was medical and/or emergency
room treatment with only one additional case requiring
hospitalization.  No fatalities were reported.

It is not certain from the summary information provided in
the Pesticide Incident Monitoring System (PIMS) report what
products or types of products were involved in these ex-
posures, or whether some incidents may have resulted from

-------
deliberate misuse and/or carelessness, or whether labeling


directions were disregarded.



There were 6 reported incidents involving children 5 years


of age or younger.  In each of these incidents there was


possible oral exposure.  In at least one of these incidents


a physician's diagnosis of pesticide poisoning was made.


Again, it is not certain what products or type of products


were involved.  These incidents occurred during a period when


the Agency did not require child-resistant packaging.  The


requirement of child-resistant packaging for products with


acute oral LDso values of 1500 rag/kg or less, approved for


residential application (40 CFR 162.16) should reduce potential


risks of accidental exposure.



The absence of reported fatalities, taken in conjunction with


the apparent adequacy of medical and/or emergency room treat-


ment in the vast majority of reported cases (only one reported


case involving hospitalization) suggests an acceptably low


level of risk associated with incidental or accidental exposure


to naled products.



     6.  Naled degrades fairly rapidly with half-lifes of


 £ 3 hours in soils and  5 25 hours in aqueous solutions.


Dichlorvos is also rapidly degraded in soil with half-lifes


of 2.3 - 8.0 hours.  Naled exhibits low to intermediate


mobility in soils, whereas dichlorovos is intermediately


mobile to mobile.  Limited data indicate that the rapid
               «

dissipation and relatively low mobility of naled and inter-

-------
mediate mobility of dichlorvos in soil will mitigate con-


tamination of ground water.




     7.  Based on studies available to assess hazards  to


wildlife and aquatic organisms, naled is characterized as


very highly toxic to bees and aquatic invertebrates.   It is


moderately to highly toxic to fish and slightly toxic  to


upland game birds and waterfowl.  Insufficient data are


available to assess the toxicity of naled  to estuarine and


marine organisms.  Label precautionary statements required


by this Standard should reduce the hazard  to fish and  other


wildlife.  After data gaps are filled, the potential hazards


to terrestrial and aquatic species will be better defined


and additional labeling requirements may be imposed.




     8.  Data are requested by the Agency  to address organic


bromide residues which may result from naled uses and  are of


human  toxicological concern.  Additional data may be requested


if these residues are found to be significant.




     9.  The wildlife risk assessment indicates that naled


residues on treated feed would not become hazardous to birds


unless sixteen (16) pounds active ingredient per acre  or


greater were applied.  Since the maximum registered application


rate is four (4) pounds active ingredient per acre the warning
    /

"Birds feeding on treated areas may be killed" is inappro-
                       •»

priate and should be deleted from all naled product labels.




                            10

-------
    10.  Under FIFRA, the Agency cannot cancel or withhold

registration simply because data are missing or inadequate

[see FIFRA Sections 3(c)(2)(B) and 3(c)(7)].  Rather, issuance

of this Standard provides a mechanism for identifying data

needs.  These data will be reviewed and evaluated when they

are received and the Agency will determine at that time

whether they will affect the registration(s) of naled.


E.  CRITERIA FOR REGISTRATION UNDER THIS STANDARD


To be covered by this Standard, products must contain naled

as the sole active ingredient, bear required labeling, and

conform to the product composition, acute toxicity limits,

and use pattern requirements listed in Section F of this

document.


The applicant for registration or reregistration of products

subject to this Standard must comply with all terms and con-

ditions described herein.  These include making a commitment

to fill data gaps on a schedule specified by the Agency.

Applicants for registration under this Standard must follow

the instructions contained in this guidance package and

complete and submit the appropriate forms within the time

specified.


F.  ACCEPTABLE RANGES AND LIMITS

                       •*
     1.  Product Composition Standard

To be covered under this Standard, manufacturing-use products

must contain naled as the sole active ingredient.  Each MP

                         11

-------
formulation proposed for registration must be fully described

and include an appropriate certification of limits for all

contaminates and impurities, and carry-over starting materials

and/or intermediates above the level of 0.1% in the technical

product.


     2.  Acute Toxicity Limits


The Agency will consider registration of technical grade

products and MPs containing naled for any acute toxicity

category/ provided that the labeling of those products bears

appropriate precautionary statements.


     3i  Use Patterns
                                 •         *

To be registered under this Standard manufacturing-use

products containing naled may be labeled for formulation

only into end-use products for:


   0 Terrestrial, food uses on: alfalfa (forage, seed),

     almonds, beans (dry, succulent), broccoli, Brussels

     sprouts, cabbage, cantaloupes, cauliflower, celery,

     chard (including Swiss), collards, cotton, cucumbers,

     eggplants, grapefruit, grapes, honeydew melons, hops,

     kale, lemons, lettuce, muskmelons, oranges, pastures

     (forage grasses and legumes)(including those for live-

     stock and dairy cattle), peaches, peas (succulent),

     peppers, pumpkins, rangeland, safflower (seed), soybeans

     (beans: dry and succulent), spinach, squash (winter,


                         12

-------
  summer),  strawberries,  sugar beets,  tangerines, tomatoes,
  turnips,  turnip greens, walnuts, and watermelons.

0 Terrestrial, non-food uses on: athletic fields, camp
  sites, cull piles, dwellings (including campers, hotels,
  motels, tourist courts, patios, and yards), fence rows,
  municipalities, ornamental conifers (including arborvitae,
  Douglas fir, hemlock, juniper, pine and spruce), ornamental
  deciduous trees (including ash, birch, black walnut, box-
  elder, crabapple,  dogwood, elm, evergreen pear, flowering
  plum, flowering/ornamental quince, locust, magnolia,
  maple, oak, sycamore, walnut, and willow), ornamental
  grasses (including dichondra), ornamental herbaceous
  plants (including  aster, Canterbury bells, carnations,
  dahlias,  daisies,  gladiolus, iris, marigold, nursery
  stock, stock, and  zinnia), ornamental lawns, ornamental
  plants (including  nursery stock), ornamental turf,
  ornamental woody shrubs (including aucaba, azalea,
  hibiscus, holly, juniper, nursery stock, pittosporum,
  privet and snowball), residential areas, roses (including
  nursery stock), sewage plants, swimming pool areas,
  theaters  (open air),  and tobacco.

0 Aquatic,  food uses on:  rice.

* Aquatic,  non-food  uses on: marinas,  swamps, swimming
  pool areas, and tid^l marshes.
                          13

-------
0 Greenhouse, food uses on:  vegetable crops (including

  cucumbers, mushrooms, and tomatoes).


0 Greenhouse, non-food uses on: ornamental plants (in-

  cluding carnations, chrysanthemum, poinsettias, roses,

  and snapdragons).


0 Forestry uses on: forest trees - conifers (including

  arborvitae, Douglas fir, fir, hemlock, juniper, pine

  and spruce), forest trees - deciduous (including ash,

  birch, black walnut, boxelder, dogwood, elm, locust,

  magnolia, maple, oak, sycamore, walnut, and willow),

  and woodlands.

                             *          *
0 Domestic, outdoor uses on: dog houses, kennels, and

  dwellings (including campers, hotels, motels, tourist

  courts, patios and yards).


0 Indoor uses on: animal buildings (for other than dairy

  cattle, poultry and pets)(including barns, feeding areas,

  shelters, and stables)(including cattle, goats, hogs,

  horses, and sheep), animal hospitals (for pets and other

  animals), calf barns, canneries, cats, cider mills,

  corrals, dairy barns (including milk rooms, equipment, and

  barnyards), dogs, dog houses, domestic dwellings (including

  campers, hotels, motels  and tourist courts), drive-ins,

  factories, feedlotSy garbage containers, garbage dumps,

  kennels (dog), livestock feeding areas, loading docks,

  meat packing establishments,  pens, poultry droppings,

                             14

-------
     poultry houses (including equipment and yards)(including

     those for chickens, pheasants,and turkeys), poultry

     packing/processing plants, restaurants, warehouses, and

     wineries.



G.  REQUIRED LABELING



All manufacturing-use products containing naled must bear

appropriate labeling as specified in 40 CFR 162.10.  Other

portions of the guidance package contain specified infor-

mation regarding label requirements.



   1.  Use Pattern Statements



The ingredients statement for MPs. must list the active

ingredient as:

      Naled, (1,2-dibromo-2,2-dichloroethy1

      dimethyl phosphate)  		%.



In addition, all MPs must state that they are intended only

for formulation into end-use products for any of the use

patterns listed above.  They must specify specific sites

listed in Use Patterns  in Section P.3.  A limiting factor

will be the data that supports these use patterns.  No use

may be included on the label, or labeling, where the registrant

fails to agree to comply with the data requirements in either

TABLE A for that use pattern, or TABLE B.

                        -*
                               15

-------
2.  Precautionary Statements


Labels for all MP products containing naled must bear state-

ments reflecting the acute human toxicity of the compound.

Naled is in Toxicity Category I on the basis of eye irritation

effects and Category II on the basis of acute oral and acute

dermal toxicity or effects.  The Agency has no valid acute

inhalation or dermal sensitization data for naled.  The re-

quired precautionary statements associated with Toxicity

Category I and II are specified in 40 CFR §162.10.

                               •»
The following environmental hazard statement must appear on

the manufacturing-use product labels:

                                •         *
   "This product is toxic to fish, aquatic invertebrates,

    and wildlife.  Oo not discharge into lakes, streams,

    ponds or public water unless in accordance with  NPDES

    permit.  For guidance contact your regional office of

    the Environmental Protection Agency."


Labeling changes to end-use products (EPs) are not required

by this Standard, however, based on data reviewed by the Agency

the following statements will be required for EPs under the

Agency's Label Improvement Program.
   o n
     This pesticide is toxic to fish, aquatic  invertebrates,

     and wildlife.  Do not apply directly to water or wet-
                       •*
     lands.  Runoff from treated areas may be  hazardous to

     aquatic organisms in neighboring areas.   Do not contamin-

     ate water by cleaning of equipment or disposal of wastes.1

                             16

-------
   °"This product is highly toxic to bees exposed to direct

     treatment on blooming crops or weeds.  Do not apply this

     product or allow it to drift to blooming crops or weeds

     while bees are actively visiting the treatment area."



The following "General Warnings and Limitations" statements

must appear on end-use product labels which bear directions

for aquatic use on food or feed crops:


   °"Do not use with highly alkaline materials such as lime

     or bordeaux mixture.  Shrimp and crabs may also be

     killed at application rates recommended.  Do not apply

     to tidal or marsh waters which are important shrimp

     producing areas."



The term "Birds feeding on treated areas may be killed" is

inappropriate and should be deleted from all labels (reference

D. Regulatory Rationale/ 9).


PR Notice 83-2, dated March 29, 1983, sets forth current

Agency policy on required label changes for reentry and

farmworker safety.  A reentry interval of 24 hours for the

use of naled on crops is required.  The Agency reserves the

right to revise this reentry interval after receipt and

review of the data required in TABLE A and TABLE B of this

Standard.

                       •*
The Agency may impose additional label requirements after the

receipt and review of the data to be submitted under this

Standard.

                            17

-------
H.  TOLERANCE REASSESSMENT


A summary of the tolerances for combined residues of naled

and 2,2-dichlorovinyl dimethyl phosphate (DDVP) in or on

raw agricultural commodities resulting from the application

of naled formulations to growing crops, livestock and poultry

(40 CFR 180.215, July 1981) is presented in Table I at the end
of this section.


Canadian and Mexican tolerances are presented for comparison;

it is not known whether these tolerances are for combined

residues of naled and ODVP or for residues of naled alone.

No international maximum residue limits (MRLs) have presently

been established by the Codex Alimentarius Commission.


United States tolerances are identical with those of Canada

and Mexico in all cases except peas and peppers, for which

the U.S. and Canadian tolerances are 0.5 ppm and Mexican

tolerances are 1 ppm (Table I).  It must be noted that the

commodities are defined differently by the respective countries

in these two cases (see footnotes b and c in Table I).  As

previously mentioned, it is not known whether Canadian or

Mexican tolerances are expressed in terms of combined residues

of naled and DDVP (as U.S. tolerances are) or in terms of

naled alone.  Based on the above, as well as the absence of

Codex MRLs for naled residues, compatibilities of international

tolerances cannot be fully assessed at this time.


                              18

-------
The components of the residue from the metabolism in plants



which are of concern are naled and DDVP, and to a lesser



extent, organic bromide.  Additional data on the residues of



organic bromide are being requested.  Tolerances exist  for



combined residues of naled and DDVP (expressed as naled) and



should continue to reflect the concern for these two components.





The components of the residue from the metabolism in animals



which are of concern are the same as those in or on plants.



However, data on the metabolism of naled in poultry are



missing and this constitutes a data gap.





The Theoretical Maximum Residue Contribution (TMRC) is  1.1021



mg/day as naled, assuming a 1.5 kg diet, based on the tolerances and



food factors for all of the commodities for which U.S.  tolerances



are established.  No Acceptable Daily Intake (ADI) or Maximum



Permissible Intake (MPI) figures have been established, due



to the absence of acceptable toxicological data for naled.



Reassessment of the established naled tolerances must await



receipt and evaluation of the required data as set forth in



TABLE A and TABLE B.





The tolerances for combined residues of naled and DDVP  are



supported for almonds (hulls and nuts), rice grain and  forage,
                                                                   /


safflower seed , sugar beet roots and tops, and fat, meat and



meat byproducts of cattle, goats, hogs, horses and sheep, and



milk.  No additional data are required for walnut meats because



the residues in the consumed portion are expected to be mininal.




                             19

-------
Tolerances are partially supported (for some uses) for forage
legumes (alfalfa), grapes, grass forage, lettuce, summer
squash, and tomatoes.
Additional data are required to support the tolerances for
beans (dry and succulent), broccoli, Brussels sprouts, cabbage,
cauliflower, celery, collards, cottonseed, cucumbers, eggplant,
eggs, grapefruit, hops, kale, lemons, melons, mushrooms,
oranges, pea forage, peaches, peas, peppers, poultry (fat,
meat, meat by-products), pumpkins, soybean forage, spinach,
strawberries, Swiss chard, tangerines, turnip tops, and .
winter squash.

Data are required on residues in.the processed products of:
citrus (any member fruit), cottonseed, grapes, hops, rice,
                        /
and tomatoes.  Data are also needed for turnip roots.  A
tolerance must be established for this commodity.
                           20

-------
TABLE I.  SUMMARY OF PRESENT TOLERANCES FOR NALED

Commodity
\
Almonds ( hulls , nuts )
Beans (dry, succulent)
Broccoli
Brussels sprouts
Cabbage
Cattle (fat, meat, meat
by-products )
Cauliflower
Celery
Citrus fruits a/
Collards
Cottonseed
Cucumbers
Eggplant
Eggs
Goats (fat, meat, meat
by-products )
Grapes
Grasses, forage
Hogs (fat, meat, meat
by-products )
Hops
Horses (fat, meat, meat *
by-products)
Tolerances (ppm)
United States Canada
0.5
0.5 0.5
1.0 1.0
1.0 1.0
1.0 1.0
0.05
1.0 1.0
3.0
"3.0 " 3.0
3.0
0.5
0.5 0.5
0.5 0.5
0.05
0.05
0.5
10.0
0.05
0.5
0.05

Mexico
—
0.5
1.0
—
__
. —
—
3.0
3.0
—
0.5
0.5
0.5
—
— —
0.5
—
-—
—


-------
TABLE I (Continued)
Commodity
Kale
Legumes/ forage
Lettuce
Melons
Milk
Mushrooms
Peaches
Peas b/
Pecans
Peppers c/
Poultry (fat/ meat/ meat
by-products)
Pumpkins
Rice
Safflower seed
Sheep (fat/ meat/ meat
by-products)
Soybeans
Spinach
Squash (summer/ winter)
Strawberries

Tolerances (ppm)
United States Canada
3.0
10.0
1.0
0.5
0.05
0.5
0.5
0.5
—
0.5
0.05
0.5
0.5
0.5
0.05
—
3.0
0.5
1.0
—
—
1.0
0.5
—
—
—
0.5
—
0.5
-—
0.5
0.5
—
—
0.5
3.0
0.5
1.0

Mexico
—
—
1.0
0.5
—
—
0.5
1.0
0.5
1.0
-—
—
0.5
—
—
0.5
3.0
0.5
1.0

-------
TABLE I (Continued)
Tolerances
Commodity United States Canada Mexico
Sugar beets (roots, tops)
Swiss chard
Tomatoes
Turnips, tops
Walnuts
All other raw agricultural
commodities except those
listed 
-------
III.  REQUIREMENT FOR SUBMISSION OF GENERIC DATA

    A.  This portion of the guidance document is a Notice
        issued under the authority of FIFRA Section 3(c)(2)(B)
        and describes, in table format, the data required
        for maintaining the registrability of each product.
        Additionally, a bibliography (Appendix III-l) is
        included that identifies that data considered as
        part of the data base supporting this standard.  EPA
        has determined that additional generic data described
        in this Notice must be submitted to EPA for evaluation
        in order to maintain in effect the registration(s)
        of your product(s) identified as an attachment to
        the cover letter accompanying this guidance document.
        As required by FIFRA Section 3(c)(2)(B), you are
        required to take appropriate steps to comply with
        this Notice.

        EPA may suspend the registration of each of those products
        unless, within the specified time, you have informed EPA
        how you will satisfy the requirements of this Notice.
        Any such suspension will remain in effect until you have
        complied with the terms of this Notice.

    B.  What Generic Data I/Must Be Submitted.  You may ascertain
        which generic data you must submit by consulting Table A
        at the end of this section.  That table shows all the
        generic data needed to evaluate the continued registrability
        of all products, and the dates by which the data must be
        submitted.  The required data must be submitted and any
        necessary studies must be conducted in accordance with
        EPA-approved protocols, the Pesticide .Registration
        Guidelines 2/, or data collected under the approved
        protocols of the Organization for Economic Cooperation
        and Development (OECD).  If you wish not to develop data
        which are necessary to support the registration or
        reregistration of certain uses appearing in your labeling,
        you may delete those uses at the time you submit your
        revised labeling.

        Also for certain kinds of testing (generally ecological
        effects), EPA requires the test substance to be a "typical
        formulation," and in those cases EPA needs data of that
    I/ Generic data pertain to the properties or effects of a
particular ingredient, and thus are relevant to an evaluation of
the risks of all products containing that ingredient (or all such
products having a certain use pattern), regardless of any such
product's unique composition or use.  Product-specific data relate
only to the properties or effects of a product with a particular
composition (or a group of products with closely similar composition)

    2/ The Pesticide Registration Guidelines were reproposed on
November 24, 1982 in 47 Federal Register 53192.
                                21

-------
        type for each major formulation category (e.g., emulsiftable
        concentrates, wettable powders, granulars, etc.)  These
        are classified as generic data and when needed are
        specified in Table A.  EPA may possess data on certain
        "typical formulations" but not others.  Note;  The "typical
        formulation" data should not be confused with product-
        specific data (Table B) which are required on each
        formulation.  Product-specific data are further explained
        in Section IV of this document.

    C.  Options Available for Complying With Requirements
        to Submit Data

        Within 90 days of your receipt of this Notice you must
    submit to EPA a completed copy of the form entitled "FIFRA
    Section 3(c)(2)(B) Summary Sheet" [EPA Form 8580-1, Appendix
    III-2] for each of your products.  On that form you must
    state which of the following methods you will use to comply
    with the requirements of this Notice:

    1.  (a) Notify EPA that you will submit the data, and

        (b) either submit the existing data you believe
            will satisfy the requirement, or state that
            you will generate the data by conducting
            testing.  If the test procedures you will
            use deviate from (or are not specified in)
            the Registration Guidelines or protocols
            contained in the Reports of Expert Groups
            to the Chemicals Group, Organization for
            Economic Cooperation and Development (OECD)
            Chemicals Testing Programme, you must enclose
            the protocols you will use.

    2.  Notify EPA that you have entered into an agreement
        with one or more other registrants to jointly
        develop (or share in the cost of developing) the
        data.  If you elect this option, you must notify EPA
        which registrant(s) are parties to the agreement.

    3.  File with EPA a completed "Certification of Attempt to
        Enter Into an Agreement With Other Registrants for
        Development of Data" (EPA Form 8580-6, Appendix III-3)V

    4.  Request that EPA amend your registration by deleting the
        uses for which the data are needed.  (This option is not
        available to applicants for new products.)
     V FIFRA Section 3(c*)(2)(B)  authorizes joint development of
data by two or more registrants,  and provides a mechanism by
which parties can obtain an arbitrator's decision if they agree
to jointly develop data but fail  .to agree on all the terms of
the agreement.  The statute does  not compel any registrant to
agree to develop data jointly.
(Footnote continued at bottom of  next page)

                            22

-------
    5.  Request voluntary cancellation of the registrations)
        of your products for which the data are needed.   (This
        option is not available to applicants for new products.)

    D.  Procedures for Requesting Changes in Testing Methodology
        and Extensions of Time

        EPA recognizes that you may disagree with our conclusions
        regarding the appropriate ways to develop the required
        data or how quickly the data must be submitted.   If the
        test procedures you plan to use deviate from (or  are not
        specified in) the registration guidelines or protocols
        contained in the reports of the Expert Groups to  the
        Chemical Groups, Organization for Economic Cooperation
        and Development (OECD) Chemicals Testing Programme, you
        must submit the protocol for Agency review prior  to the
        initiation of the test'.

        If you think that you will need more time to generate the
        required data than is allowed by EPA's schedule,  you may
        submit a request for an extension of time.  The extension
        request must be submitted in writing to the Product
        Manager.  The extension request should state the  reasons
        why you conclude that an extension is appropriate.  While
        EB& considers your request, you must strive to meet the
        deadline for submitting the' required data.
(Footnote continued from previous page)
     In EPA's opinion, joint data development by all registrants
who are subject to the requirements to submit a pertinent item
of data or a cost-sharing agreement among all such registrants
is clearly in the public interest.  Duplication of testing could
increase costs, tie up testing facilities, and subject an unneces-
sarily large number of animals to testing.
      As noted earlier, EPA has discretion not to suspend the
registration of a product when a registrant fails to submit data
required under FIFRA Section 3(c)(2)-(B).  EPA has concluded that
it is appropriate to exercise its discretion not to suspend in
ways which will discourage duplicative testing.  Accordingly, if
(1) a registrant has informed us of his intent to develop and
submit data required by this Notice; and (2) a second regis-
trant informs EPA that it has made a bona fide offer to the
first registrant to share in the expenses of the testing [on
terms to be agreed upon or determined by arbitration under FIFRA
Section 3(c)(2)(B)(iii)]; and (3) the first registrant has declined
to agree to enter into a cost-sharing agreement, EPA will not
suspend the second firm's*registration.  While the first firm is
not required to agree to jointly develop data, EPA is not required
to force the second firm to engage in economically inefficient
duplicative testing in order to maintain its registration.
                             23

-------
                                                         TABLE A
                                        GENERIC DATA REQUIREMENTS FOR HALED I/
Data Requirement
Composition"
                 Does EPA Have Data
                 To Satisfy This
                 Requirement?  (Yes,
                 No or Partially)
                       Bibliographic
                         Citation V
                  Must Additional
                  Data Be Submitted
                  Under FIFRA Section
                 3(c)(2)(B)? V
§158.120

63-3 -
63-4 -
Product Chemistry
(continued)
Physical State TGAI Yes
Odor TGAI Yes

00074790
G5092040
00074790
G5092040

No
No
  63-5 - Melting Point

  63-6 - Boiling Point
  63-7 - Density, Bulk Density, or
         Specific Gravity
TGAI

TGAI


TGAI
Yes

Yes


Partial
G5092040                 No

00074653| 00074724*      No
00074790; G5092040

00074653? 00074724*      Yes 8/
00074790; G5092040
  *Data submitted by Chevron Chemical Company.  These data may be compensable.

-------
                                                     TABLE A
                                     GENERIC  DATA REQUIREMENTS FOR NALED I/
Does EPA Have Data
To Satisfy This
2/ Requirement? (Yes, Bibliographic
Data Requirement Composition No or Partially) Citation V
Must Additional
Data Be Submitted
Under FIFRA Secti<
3(c)(2)(B)? V
§158.120 Product Chemistry
63- 8
63- 9
63-10
63-11
63-12
63-13
Other
(continued)
- Solubility TGAI OR PAI Yes
- Vapor Pressure TGAI OR PAI Yes
*
- Dissociation constant TGAI OR PAI No
- Octanol/water partition PAI No
coefficient
- pH TGAI No
- Stability TGAI Yes
Requirements;
00074653
00074790
GS092040
00074653
00074790
GS092040
-
-
-
00074653
00074724
00074790
No
No
Yes
Yes
Yes
No
64- 1 - Submittal of samples
Choice
No 9/

-------
                                                      TABLE A
                                      GENERIC DATA REQUIREMENTS FOR NALED

  §158.120 Product Chemistry
           (continued)

I/ Naled 90% technical is the only technical product.  The cited data may be used to satisfy the requirements for
   technical naled manufactured by the process submitted by the Chevron Chemical Co. (00074653 and 00074791)
   containing 90% naled (or similar percentages accepted on a product by product basis).
2/ Composition:  TGAI = Technical grade of the active ingredient; PAI = Pure active ingredient; Choice = Choice of
   several 'test substances determined on a case-by-case basis.
3/ All data cited were submitted by the Chevron Chemical Company.
4/ Data must be submitted no later than	Juna lqfifi	•
V Adequate data has been submitted by Chevron Chemical Company.  Other producers must address these data requirements.
|/ The analytical methods used were inadequately described.  Identification and quantification of impurities present
   at >0.1% (W/W) is required.
7/ There was a discrepancy of the limits.  An update of the technical naled limits and quality control method
   (including validation data); adequate sampling (five or more production batches); and limit certification are required
8/ The data are conflicting.  Clarification of the specific gravity of technical naled is required.
9/ May be required on a case-by-case basis.

-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
Data Requirements
Composition
                                                     I/
Does EPA Have Data
To Satisfy This
Requirement?  (Yes,
No. or Partially)
Bibliographic
  Citation
Must Additional
Data Be Submitted
Under FIFRA Section
 3(c)(2)(B)?2/
§158.125 Residue Chemistry

  171-4 - Nature of Residue (Metabolism)

        - Plants
   PAIRA
        - Livestock
PAIRA and plant
 metabolites
        - Animal residues
  171-4 - Storage Stability Data
    PAI
    Partial
    Partial
  171-4 - Residue Analytical Method

        - Plant residues                  TGAI and metabolites    Partial
TGAI and metabolites    Yes
    No
00074836
GS092090*
00074654
00074647

00074844
00059386
GS092091*
GS092092*
                       00074721; 00074806*
                       00074647; 00073820
                       00074725

                       GS092026
                       00073821*
       Yes 3/,4/
       Yes 3/
                                                                    Yes 4/
                         No
                         Yes 5/
  *Data submitted by Chevron Chemical Company.  These data may be compensable.

-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
Data Requirements
Composition"
                Does EPA Have Data
                To Satisfy This
                Requireroent?  (Yes,
                No, or Partially)
                                                                         Bibliographic
                                                                           Citation   •
                                                                                             Must Additional
                                                                                             Data Be Submitted
                                                                                             Under  FIFRA Section
                                                                                               3(c)(2)(B)?2/
S158.125 Residue Chemistry
         (continued)

  171-4 - Magnitude of the Residue-
           Residue Studies for Each
           Food Use 6/

        - Root and Tuber Vegetable Group
                *
            0 Sugar Beet Roots
   0 Turnip Roots

- Leaves of Root and Tuber
  Vegetables (Human Food or
  Animal Feed) Group  8/

   0 Sugar Beet Tops
 0 Turnip Tops

Leafy Vegetables Group
(Except Brassica)

 0 Celery
            0 Lettuce

            0 Spinach

            0 Swiss Chard
TEP
                                              TEP
                                              TEP
                                              TEP
TEP


TEP

TEP

TEP
                                                   Yes
                No
                Yes
                Partial
                                                     Partial


                                                     Partial

                                                     Partial

                                                     Partial
                                                                            00074836;  00073821*;
                                                                            00073815*; 00073819*
                                           00074836; 00073821*;
                                           00073815*; 00073819*

                                           00073820
                                           00074836; 00073821*;
                                           00074722

                                           00073820; 00074807

                                           00073820; 00074722

                                           00074836
                                                                    No
                                                                                                   Yes  7/
No 9/


Yes 10/




Yes ll/


Yes \2/

Yes 13/

Yes 13/
  *Data submitted by Chevron Chemical Company.  These data may be compensable.

-------
                                                      TABLE A
                                       GENERIC DATA REQUIREMENTS FOR NALED
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
I/ Requirenrent? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2/
§158.125 Residue Chemistry
(continued)
171-4 - Magnitude of the Residue -
Residue Studies (continued)
- Brass ica (Cole) Leafy
Vegetable Group
0 Broccoli TEP Partial
0 Brussels Sprouts TEP No
0 Cabbage TEP Partial
0 Cauliflower TEP Partial
0 Collards TEP Partial
0 Kale TEP Partial
- Legume Vegetables (Succulent
and Dried) Group
0 Beans TEP Partial
0 Peas TEP Partial
0 Soybeans TEP Partial



00074836; 00073820
-
00074836
00073820
00073821*
00073821*
00074836; 00073846*;
00073820; 00074699;
00073821; 00074729
00073846*
00073821*; 00073846*



Yes 14/
Yes 15/
Yes U/
Yes 14/
Yes JL4/
Yes 14/
Yes 16/
Yes IT/
Yes IB/
*Data submitted by Chevron Chemical Company.These data may be conpensable

-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
Data Requirement
§158.125 Residue Chemistry
(continued)
- Foliage of Legume
Vegetables Group
0 Bean Foliage
*
0 Pea Foliage
0 Soybean Foliage
~ Fruiting Vegetables
(Except Cucurbit) Group
0 Eggplants
0 Peppers
0 Tomatoes
- Fruiting Vegetables
(Cucurbit) Group
0 Cucumbers
0 Melons
0 Pumpkins
0 Summmer Squash
0 Winter Squash
y
Composition

TEP
TEP
TEP

TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)

Partial
Partial
Partial
-
No
Partial
Partial
Partial
Partial
No
Partial
No
Must Additional
Data Be Submitted
Bibliographic Under FIFRA Section
Citation 3(c)(2)(B)?V

00074836; 00073820;
00073821*; 00073846*;
00074699; 00074729
00073846*
00073821*; 00073846*

-
00074836*; 00073820
00074836; 00073820;
00075668
00073820; 00075668
00073820
-
00073820
-

Yes 19/
Yes 20/
Yes 21/

Yes 22/
Yes 23/
Yes 24/
Yes 25/
Yes 26/
Yes 27/
Yes 28/
Yes
*Data submitted by Chevron Chemical Company.  These data may be compensable.

-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
Data Requirement
                                          Composition
                                                     I/
Does EPA Have Data
To Satisfy This
Requirement?  (Yes,
No or Partially)
               Must Additional
               Data Be Submitted
Bibliographic  Under FIFRA Section
  Citation      3(c)(2)(B)? 2
§158.125 Residue Chemistry
         (continued)
          - Citrus Fruits (Citrus Spp.,
            Fortunella Spp.) Group

             0 Grapefruit

             0 Lemons

             0 Oranges

             0 Tangerines

          - Stone Fruits Group

             0 Peaches

          - Small Fruits and
            Berries Group

             0 Grapes


             0 Strawberries

          - Cereal Grains Group

             0 Rice Grain
TEP

TEP

TEP

TEP



TEP
                                          TEP
                                          TEP
                                          TEP
                                                              No

                                                              Partial

                                                              Partial

                                                              No



                                                              Partial
Partial
Partial
Partial
                       00073820

                       00073820; 00074807
                         Yes

                         Yes 29/

                         Yes 30/

                         Yes
                       00074836*? 00073821*     Yes 31/
00074836; 00073821*;     Yes 32/
00074728; 00073817*

00073820                 Yes 33/
00074723; 00073820;      Yes 34/
*Data submitted by Chevron Chemical Company.These data may be ccmpensable.

-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
Data Requirement
Composition
                                                     I/
Does EPA Have Data
To Satisfy This
Requ i rement?  (Yes,
No or Partially)
Bibliographic
  Citation
Must Additional
Data Be Submitted
Under FIFRA Section
 3(c)(2)(B>? 2
§158.125 Residue Chemistry
         (continued)
          - Forage, Fodder, and Straw
            of Cereal Grains Group

             0 Rice Forage

          - Grass., Forage, Fodder
            and Hay Group

             0 Grass Forage (Pasture
               and Range)

          - Non-Grass Animal Feeds
TEP
Yes
TEP
Partial
00074723
00073820
00073816*
       No 35/
       Yes 36/
(Forage. Fodder, Straw,
and Hay) Group
0 Alfalfa TEP Partial
•.
- Tree Nuts Group 38/
0 Alnonds TEP Yes
0 Walnuts TEP Yes

00074836; 00073821*;
00073818*; 00072816

00073830
00073821*

Yes 37/


No 39/
No
*Data submitted by Chevron Chemical Company.  These data may be conpensable.

-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
Data Requirement
          !/
Composition
Does EPA Have Data
To Satisfy This
Requirement?  (Yes,
No or Partially)
Bibliographic
  Citation
Must Additional
Data Be Submitted
Under FIFRA Section
  3(c)(2)(B)? 2
§158.125 Residue Chemistry
         (continued)

          - Miscellaneous

             0 Cottonseed
             0 Hops

             0 Mushrooms

             0 Safflower Seed
          j
          - All Other Agricultural
            Commodities

          - Food Producing Animals
TEP


TEP

TEP

TEP

TEP
Partial


Partial

Partial

Yes

No
00074700} 00073821*}
00074845*

00073846*

GS092093

00073846*} 00074845*
       Yes 40/


       Yes 41/

       Yes 42/

       No 43/

       No 44/
0 Meat and milk EP, TGAI or plant Yes •
metabolites
0 Poultry and eggs EP/ TGAI or plant Partial
metabolites
GS092094
GS092092*
GS092095*
00073821*
GS092026
GS092096
00074692*
No 45/
Yes 46/,47/
*Data submitted by Chevron Chemical Company.  These data may be compensable.

-------
                                                       TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED

 §158.125 Residue Chemistry
          (continued)

 I/ Composition:   TGAI = Technical grade of the active ingredient;  PAIRA = Pure active ingredient,  radiolabelled;  TEP
    Typical end-use product? EP = End-use product.
 2/ Data must be submitted no later than _ tnn^  IQRA
 3/ Data are needed on the identity and amount ( if any)  in plants and animals of organic brominated components of the
    residue derived from naled itself or from its bromine-containing impurities.  A protocol for this study must be
    submitted and approved by the Agency, prior to initiation of the study. The protocol must include a scheme for
    tracking organic-brominated residues.
 4/ Methodology and data on residues of naled and DDVP determined separately for two representative crops such as lettuce
    and rice grain are needed.
 5/ Some residue^ storage data is required to indicate a  potential for the loss of residues between sampling and analysis.
 6/ The following agricultural commodities are arranged  in order of crop groups in accordance with Draft Proposed
    40 CFR 180.34(f ) [see FR 47(93)20635(5-13-82)1 .  Satisfaction of the crop group requirements for a given group would
    allow the establishlment of a tolerance for all members of that group.  To satisfy the requirements, the use patterns
    must be similar for all members of the crop group and maximum residues (tolerances) generally must not vary by more
    than a factor of five.  Residue data for all of the  representative commodities, or suitable substitutes, must be
    presented in order to establish a group tolerance? these representative crops are listed under the crop group sections
    which follow.
 7/ No tolerances exists for turnip roots, yet residues  are to be expected from the use on naled on turnips.  These
    residues need to be covered by either a crop group tolerance (as previously indicated) or an individual tolerance.
    The lack of residue data on turnip roots constitutes a data gap for an individual tolerance, should one be requested.
 8/ Data are available for both of the two representative commodities (sugar beet tops and turnip tops) needed to satisfy
    the requirements for this crop group.  Based on the  available data, however, a group tolerance cannot be established
    for the following reasons: 1) Residue data for turnip tops do not support the established tolerance, 2) Naled uses  for
    turnips and sugar beets are substantially different  in terms of the rates and formulations applied for, and 3) The
    tolerances for sugar beet tops (0.5 ppm) and turnip tops (3.0 ppm) differ by ;more than a factor of five.
 9/ The available data support the tolerance for combined residues of naled and DDVP in or on sugar beet tops from the
    established use, and even under exaggerated rates of application.  The restriction against feeding sugar beet tops
    to livestock appears unnecessary.
10/ Data are needed which reflect aerial and ground applications of the 4 or 6% Dusts (D) and 7.2 Ib/gal Emulsifiable
    Concentrates (ECs) according to the use pattern.  This will include five or more applications per season at the
    highest recommended rates.

-------
                                                       TABLE A
                                         GENERIC DATA REQUIREMENTS FOR NALED

§158.125 Residue Chemistry
         (continued)

ll/ Data are needed which reflect the following: 1) Five or more ground applications of the 7.2 Ib/gal EC at 1.35 Ib ai/A,
    2) Five or more aerial applications of the 4 or 6% D at 2.0 Ib ai/A, and 3) Five or more ground applications of the
    4 or 6% D at 2.0 Ib ai/A.
12/ The available data support the established tolerance for head lettuce after applications of the 7.2 Ib/gal EC.
    Additional data are required which reflect both aerial and ground applications of either the 4 or 6% D; at least three
    applications at 2.0 Ib ai/A must be made.  All of the above data are required for leaf lettuce as well (including data
    for the 7.2 Ib/gal EC).  These data are to include at least one study to show residues in head lettuce, with and
    without wrapper leaves.
13/ Data are needed which reflect aerial and ground applications of the 4 or 6% dusts and the 7.2 Ib/gal EC according to
    the use pattern.  This will include five or more applications per season at the highest recommended rates.
14/ Data are needed which reflect five or more seasonal applications, with aerial and ground equipment, of the 4 or 6% D
    at 2.01b ai/A and of the 7.2 Ib/gal EC at 1.8 Ib ai/A.
15/ No residue data for Brussels sprouts are available for review} the tolerance can be supported by grouping with other
    crops whose tolerances are supported, or by residue data for the individual tolerance.
16/ Data are required which reflect three or more applications of the 7.2 Ib/gal EC and the 4  or 6% D formulations
    during the fruiting period with aerial and ground equipment.  .
IT/ Data are required which reflect at least three applications of the 4% D and the 7.2 Ib/gal EC at the maximum rates
    during the fruiting period.  Both aerial and ground equipment must be used.  Dried, succulent, and edible-pod types
    must be included.
18/ Data are needed which reflect at least five aerial and ground applications of the 7.2 Ib/gal EC at 1.35 Ib ai/A;
    three of these treatments must be made during the fruiting period.  Data are also needed to determine the residues
    in processed soybean products (crude and refined oil, hulls, meal, and soapstock) to establish the necessity of
    food additive tolerances for residues in these products.
19/ Data are required which reflect three or more applications of the 7.2 Ib/gal EC and the 4 or 6% D formulations with
    aerial and ground equipment.  The restriction against feeding bean forage to livestock appears unnecessary.
20/ Data are required which reflect at least three applications of the 4% D and 7.2 Ib/gal EC at the maximum rates be
    made during the fruiting period using aerial and ground equipment.
21/ Data are needed which reflect at least five aerial and ground applications of the 7.2 Ib/gal EC at 1.35 Ib ai/A for
    forage; three of these treatments must be made during the fruiting period for residue studies on pods and vines.
22/ No residue data for eggplant are available for review; the tolerance can be supported by grouping with other fruiting
    vegetables (except cucurbits) whose tolerances are supported, or by residue data for the individual tolerance.

-------
                                                       TABLE A
                                         GENERIC DATA REQUIREMENTS FOR NALED

§158.125 Residue Chemistry
         (continued)

23/ Data are needed which reflect five aerial and ground applications of the 4% D and the 7.2 Ib/gal EC; at least three
    of these applications must be made during the fruiting period.
24/ The available data support the established tolerance for tomato fruit following ground applications of the 7.2 Ib/gal
    EC.  Data are still needed which reflect: 1) Five aerial applications of the 7.2 Ib/gal EC at 0.9 Ib ai/A (at least
    three applications must be made during the fruiting period), 2) Five aerial and ground applications of the 4% D at
    2.0 Ib ai/A (at least three applications must be made during thr fruiting period, 3) Five foliar greenhouse sprays
    with the 7.2 Ib/gal EC at 0.9 Ib ai/100 gal (at least three applications must be made during the fruiting period),
    4) Ten greenhouse fumigations with the RTU and 7.2 Ib/gal EC at 16 fl oz of product/50,000 cu ft, and 0.28 Ib
    ai/50,000 cu ft, respectively, (at least five applications must be made during the fruiting period), and 5) Residues
    in processed*tomato products (ketchup, paste, and wet and dry pomace).
25/ Data are needed which reflect the following: 1) Five aerial and ground applications of the 4% D at 2.0 Ib ai/A (at
    least three applications must be made during the fruiting period), 2) Five aerial and ground applications of the
    7.2 Ib/gal EC at 1.35 Ib ai/A (at least three applications must be made during the fruiting period), and 3) Ten
    greenhouse fumigations using the 7.2 Ib/gal EC and 10% RTU at 0.28 Ib ai/50,000 cu ft and 16 oz product/50,000 cu ft,
    respectively (at least five applications must be made during'the fruiting period).
26/ Data are needed which reflect the following: Five aerial and ground applications of the 4% D at 2.0 Ib ai/A (at least
    three applications must be made during the fruiting period).
27/ Data are needed which reflect the following: 1) Five aerial and ground applications of the 4% D at 2.0 Ib ai/A (at
    least three applications must be made during the fruiting period), and 2) Five aerial and ground applications of the
    7.2 Ib/gal EC at 1.35 Ib ai/A (at least three applications must be made during the fruiting period).  The available
    data on rice straw are applicable to other grain straws and indicate that these contribute substantially to the
    bromide ion content of the animal diet.
28/ The available data support the established tolerance for summer squash treated with ground applications of the
    7.2 Ib/gal EC.  Additional data are required which reflect the following: 1) Five aerial applications of the
    7.2 Ib/gal EC at 1.35 Ib ai/A (three or more applications must be made during the fruiting period), and 2) Five
    aerial and ground applications of the 4% D at 2.0 Ib ai/A (three or more applications must be made during the
    fruiting period).
29/ Data  are needed which reflect 10 aerial and ground applications of the 4% D and 7.2 Ib/gal EC at 4.0 and 1.8 Ib
    ai/A, respectively; five or more of these applications must be made during the fruiting period.
30/ Data are needed which reflect 10 aerial and ground applications of the 4% D and 7.2 Ib/gal EC at 4.0 and 1.8 Ib
    ai/A, respectively; five or more of these applications must be made during the fruiting period.  Data is also
    needed on processed products, cold pressed oil, peel, dehydrated pulp and molasses (fractionation study).

-------
                                                       TABLE A
                                         GENERIC DATA REQUIREMENTS TOR NALED

§158.125 Residue Chemistry
"(continued)

31/ Data are required which include the following; 1) Ten ground applications of the 7.2 Ib/gal EC at 0.68 Ib ai/100 gal
    sprayed to the point of runoff, 2) Ten aerial and ground applications of the 4% D at 3.2 Ib ai/A.
32/ The available data support the established tolerance for grapes based on residues resulting from ground application of
    the 7.2 Ib/gal EC.  Additional dat are required which reflect 10 aerial and ground applications of the 4% D at 2.0 Ib
    ai/A.  Also, data pertaining to naled residues in the following grape products (juice, wet and dehydrated pomace,
    raisins, and raisin waste) are needed to determine if food additive tolerances should be established for these
    products.
33/ Data are required which reflect five aerial and ground applications of the 4 or 6% D at 2.0 Ib ai/A and the 7.2
    Ib/gal EC at 0.9 Ib ai/A.
34/ The available data support the established tolerance for residues of naled and DDVP in or on rice resulting from the
    use of the 7.2 Ib/gal EC.  Data are required for rice products (hulls and milled products and by-products) to
    determine if feed additive tolerances need be established for these products.
35/ The available data support the established tolerance for residues of naled and DDVP in or on rice forage resulting
    from the use of the 7.2 Ib/gal EC.
36/ The available data support the established tolerance on pasture and range grasses for foliar ground application of
    the EC and SC/L formulations.  Data are required, however, which reflect five aerial applications of the EC
    and one of the SC/L formulations at 0.9 and 0.75 Ib ai/A, respectively.  Also, residue data are required which reflect
    five aerial and ground applications of the 4% D at 0.4 Ib ai/A.  In addition, residue data for grass hay are needed
    to determine if a separate, or increased, tolerance should be established for this dehydrated product.
37/ The available data support the established tolerance for alfalfa forage following treatment with the EC and SC/L
    formulations.  Additional data are required which reflect five aerial and ground applications of the 4% D.  Residue
    data for alfalfa hay are also needed to determine if a separate, or increased, tolerance should be established for
    this dehydrated product.
38/ A group tolerance may not be established at this time because the almond and walnut uses are distinctly different,
    and because additional data are required for pecans.
39/ The available data support the established tolerance for almond hulls and nuts following a dormant application.  In
    addition, the data indicate that three foliar applications at 3.0-6.0 Ib ai/A do not result in tolerance-exceeding
    residues in or on almond hulls and meats 28 days after the final treatment.  The use pattern could thus be expanded
    to include foliar applications of the 7.2 Ib/gal EC if such a need is anticipated.

-------
                                                       TABLE A
                                         GENERIC DATA REQUIREMENTS FOR NALED


S158.125 Residue Chemistry
         (continued)

40/ Data are required for cottonseed which reflect five aerial and ground applications of the 4% D and 7.2 Ib/gal EC at
    1.4 and 0.9 Ib ai/A, respectively.  If residues are, in fact, present in undelinted seed, then additonal residue
    data (reflecting the above doses) for cottonseed hulls, meal, refined oil, and soapstock are required to determine
    if food additive tolerances should be established for these proccessed products.
41/ Data are required on hops which reflect five aerial and ground applications of the 4% D and 7.2 Ib/gal EC at 1.0 and
    0.9 Ib ai/A, respectively.  Also, data are required concerning residues in dried spent hops.
42/ Data from the following uses are needed: 1) 20 applications of the 7.2 Ib/gal EC used as a KIU at 6.75 oz ai/50,000
    cu ft, and 2)  20 applications of the 10% RTU at 5 fl oz/50,000 cu ft.
43/ The available data support the established tolerance for combined residues of naled and DDVP in or on safflower seed
    and indicate^, that food additive tolerances need not be established for safflower meal and oil.  This data cannot be
    translated to other oilseeds because their fractions inlude hulls and soapstock.
44/ A tolerance of 0.5 ppra is established for combined residues on naled and DDVP in or on all raw agricultural
    commodities, except those otherwise listed in 40 CFR 180.125 (July 1981), from use of naled formulations for area
    pest (fly and mosquito) control.  The recommended rates are consistently lower (frequently 0.02-0.25 Ib ai/A) for
    area pest uses than for crop pest uses (usually 0.68-4.0 Ib ai/A).  Although it is a major use on naled formulations,
    area pest usage will result in intermittent and variable exposure of a given commodity to naled residues.  For these
    reasons, the submission of data to support this extensive tolerance is not required.  All commodities included in this
    tolerance will, of course, be subject to enforcement of this tolerance.
45/ The available data support the established tolerances for combined residues of naled and DDVP from dietary sources in
    the meat and milk of cattle.  The data are considered supportive of the tolerances for residues in the meat and milk
    of otherr animals (goats, hogs, horses and sheep) as well.  The contribution of combined residues on naled and DDVP to
    meat and milk from the use of naled at its reduced rates on or around livestock is not expected to be significant in
    relation to the levels which result from dietary sources.
46/ Residue data are needed on eggs and poultry resulting from 10 bird-spray treatments with either the 3.6 or 7.2 Ib/gal
    EC at 0.45 Ib ai/20 gal.
47/ Data submitted to the Agency was conducted by Industrial Bio-Test Laboratories (IBT) and has been determined to be
    invalid.

-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
Data Requirement
           I/     Use  2/
Coropoaition     Pattern
             Does EPA Have Data
             To Satisfy This
             Requirement?  (Yes,
             No or Partially)
                                      Must Additional
                                      Data be Submitted
                       Bibliographic  Under FIFRA Section
                         Citation      3(c)(2)(B)?3/
§158.130 Environmental Fate

  DEGRADATION STUDIES-LAB;

  161-1 - Hydrolysis

  Photodegradation

  161-2 - In water

  161-3 - On soil

  161-4 - In Air

  METABOLISM STUDIES-LAB;

  162-1 - Aerobic Soil


  162-2 - Anaerobic Soil

  162-3 - Anaerobic Aquatic

  162-4 - Aerobic Aquatic


  MOBILITY STUDIES;
TGAI or PAIRA   A,B,C,D,
                E,F,G,H
TGAI or PAIRA   A,B,C,G

TGAI or PAIRA   A,G

TGAI or PAIRA   A,C,E,F



TGAI or PAIRA   A,B,D,E,
                F,H

TGAI or PAIRA   A,G
         i
TGAI or PAIRA   C,D,G
         i
TGAI or PAIRA   CfD
  163-1 - Leaching and           TGAI or PAIRA   A,B,C,D,
          Adsorption/Desorption           '.       E,F,G,H
  163-2 - Volatility (Lab)

  163-3 - Volatility (Field)
    TEP

    TEP
A,E,F

A,E,F 8/
No



No

No

No
    •


Partial 4/


No 5/

No

Partial 6/




Partial 7/


No

No
                                     00074759*
                                      00074691*
                                      00074885*
                                      00074644**
                                                      00064796*
Yes



Yes

Yes

Yes



Yes


Yes

Yes

Yes
 Yes


Yes

Reserved 9/
 *Data submitted by Chevron Chemical Company.  These data may be compensable.
**Data submitted by National Chemsearch, Division ,of NCH Corp.  These data may be compensable.

-------
                                                       TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
JL/ Use 2/ Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition Pattern No or Partially) Citation 3(c)(2)(B)?V
§158.130 Environmental Fate

(continued)



DISSIPATION STUDIES-FIELD:
164-1
164-2
164-3
164-4
164-5
- Soil
- Aquatic (Sediment)
- Forestry
- Combination and
Tank Mixes
- Soil, Long-term
TEP
TEP
TEP j
i
TEP
TEP
A,B,H
C,D
G

A
No - Yes
Partial 10/ 00074645* Yes
No - Yes
Not Applicable
*
Reserved ll/
ACCUMULATION STUDIES: :
165-1
165-2
165-3
165-4
165-5
- Rotational Crops
(Confined)
- Rotational Crops
(Field)
- Irrigated Crops
- In Fish
- In Aquatic Non-Target
Organisms
PAIRA
i
TEP
TEP
TGAI or
PAIRA
TEP
A
A
C
A,B,C,
D,G
D
No - Yes
No - Reserved 12/
No - Yes
Yes 00074643* No 13/
Yes 00074643* No
*Data submitted by National Chemsearch, Division of NCH Corp.   These data may be conpensable.

-------
                                                       TABLE A
                                      GENERIC DATA REQUIREMENTS FOR NALED


  §158.130 Environmental Fate
           (continued)

 \J Composition:  TGAI = Technical grade of the active ingredient; PAIRA = Pure active ingredient, radiolabelled;
    TEP = Typical end-use product.        '
 2/ The use patterns are coded as follows;  A=Terrestrial, Food Crop; B=Terres trial, Non-Food; C=Aquatic, Food Crop;
    D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
 3/ Data must be submitted no later than _ _ .Tlinp  i
                                         _ _        _
 4/ Tests with specified purity of radiolabeled or technical material required (composition test material not given).
 5/ Anerobic aquatic studies replace the anerobic soil studies.
 6/ Half-life was given, but only on one metabolite (DDVP).  No information was given on DDVP metabolism, nor on
    sediment.  Data from the intended use area(s) is required.
 7/ Aged leaching, tests are required to i dent if iy metabolites and degradation rates.  No absorption/desorption data
    were submitted, therefore all data are required.
 8/ Label modifications for the greenhouse use may be necessary because of high volatility and toxicity (Category II)
    of the metabolite DDVP.  A decision will be made after an additional aerobic soil metabolism study is submitted
    and evaluated.
 9/ Data requirement depends on the results of the laboratory studies.
10/ Partial information obtained from sewage water; additional data required on dissipation from other aquatic
    impact areas.
ll/ This study is required only if the aerobic soil metabolism study described in 162-1 demonstrates that for
    field and vegetable crop use, the total amount of pesticide, excluding bound residues in soil, is greater
    than 50% of the amount of pesticide initially applied at the time when a subsequent application would occur.
12/ Reserved pending results of 165-1.
13/ No data on the accumulation of naled in fish are required because 1) naled has a half life of less than 4 days
    in water, 2) naled has an octanol water partition coefficient of less than 1000, and 3) no detectable residues
    were found in fish samples.

-------
                                                       TABLE A
                                        GENERIC DATA REQUIREMENTS FDR NALED
Does EPA Have Data
To Satisfy This
I/ Use 2/ Requirement? (Yes, Bibliographic
Data Requirement Composition Patterns No or Partially) Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
§158.135 Toxicology
ACUTE TESTING:
81-1

81-2
81-3
81-7
- Oral LD5Q - Rat TGAI A,B,C,D,E Yes
F,G,H,I

- Dermal ID$Q - Rabbit TGAI A,B,C,D,E, Yes
F,G,H,I
- Inhalation LCso - Rat TGAI A,B,C,D,E, No •
F,H,I
- Delayed TGAI A,B,C,D,E, Yes
Neurotoxicity - Hen F,G,H,I
00049330
00074795
05016607
00065468
00074829*
00074663
00049330
-
00074656*
00074843
No

No
Yes
No
SUBCHRONIC TESTING:
82-1

82-2
82-3
82-4
82-5
- 90-Day Feeding - TGAI A,D,E,I Yes
Rodent, Non-rodent

- 21-Day Dermal - Rabbit TGAI A,B,H,I No
- 90-Day Dermal - Rabbit TGAI Reserved 4/
- 90-Day Inhalation - TGAI E,F,I No
Rat
- 90-Day Neurotoxicity- TGAI No
Hen/Mammal
00074817
05016607
GS092097*
00074862
-
-
-
—
No

Yes
-
Yes
No 5/
*Data submitted by Chevron Chemical Company.  These data may be compensable.

-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
Data Requirement
                          Does EPA Have Data
                          To Satisfy This
           I/   Use  2/   Requirement?  (Yes,
Composition   Pattern     No or Partially)?
                                    Bibliographic
                                      Citation
                   Must Additional
                   Data Be Submitted
                   Under FIFRA Section
                     3(c)(2)(B)?2/
§158.135 Toxicology
         (continued)

  CHRONIC TESTING;

  83-1 - Chronic Toxicity -
          2 species:  Rodent
          and Non-rodent
                 «
  83-2 - Oncogenicity -
          2 species:  Rat and
          Mouse preferred

  83-3 - Teratogenicity -
          2 species

  83-4 - Reproduction - Rat
          2-generation

  MUTAGENICITY TESTING

  84-2 - Gene Mutation

  84-2 - Chromosomal Aberration

  84-2 - Other Mechanisms of
          Mutagenicity

  SPECIAL TESTING

  85-1 - General Metabolism
   TGAI
A,B,C,E,H,I     No
   TGAI     A,B,C,E,H,I




   TGAI     A,B,C,E,H,I


   TGAI     A,B,C,E,H,I





   TGAI     A,B,C,E,H,I

   TGAI     A,B,C,B,H,I

   TGAI     A,B,C,E,H,I
   PAI or   A,B,C,E,H,I
   PAIRA
                No
                No
                No
  85-2 - Domestic Animal Safety     Choice   B,HfI
                Partial 7/,9/

                No

                No




                Reserved 7/,10/


                Reserved 10/
GS092103
Yes 6/,7/



Yes 6/,7/



Yes 7/,8/


Yes 6/,7/




Yes

Yes

Yes

-------
                                                       TABLE A
                                      GENERIC DATA REQUIREMENTS FOR NALED


 §158.135 Toxicology
          (continued)

 I/ Composition: TGAI = Technical grade of the active ingredient; PAI = Pure active ingredient; PAIRA = Pure active
    ingredient, radiolabelled; Choice = Choice of several test substances determined on a case-by-case basis.
 2/ The use patterns are coded as follows:  A=Terrestrial, Food Crop; B=Terrestrial/ Non-Food? OAqautic, Food Crop;
    D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
 3/ Data roust be submitted no later than  	June 1986	.
 4/ Reserved pending results of 82-2 (21-day dermal).
 5/ Not required since 81-7 (acute delayed neurotoxicity) does not show neurotoxicity.
 6/ This study is to be completed by April 3, 1985, in accordance with the 3(c)(2)(B) Data Call-in Notice issued
    April 3, 1981.
 7/ Data previously sbumitted to the Agency was conducted by Industrial Bio-Test Laboratories (IBT) and has been
    determined to be invalid.
 8/ This study is to be completed by September 3, 1983, in accordance with the 3(c)(2)(B) Data Call-in Notice issued
    April 3, 1981 and a request for a 3-month extension.
 9/ This data requirement is statisfied for bacterial testing only.
10/ Reserved pending results of subchronic and chronic testing. .

-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
                                                           Does EPA Have Data
                                                           To Satisfy This
                                            I/        2/   Requirement?  (Yes,
Bibliographic
Must Additional
Data Be Submitted
Under FIFRA Section
Data Requirement Composition Pattern No or Partially) Citation 3(c)(2)(B)?3/
§158.140
132-1 -
132-1 -
133-3 -
133-4 -
Reentry Protection
Foliar Dissipation TEP A,B No
Soil Dissipation TEP A,B No
Dermal Exposure TEP A,B No
Inhalation Exposure TEP A,B No

Yes 4/
No 5/
No 5/
No 5/
I/ Composition: TEP = Typical end-use product.                      >j
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food;  O=Aquatic,  Food Crop;
   D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indcor.
3/ Data must be submitted no later than    June 1986	.
4/ Use California reentry interval of 24 hours for all crops, or submit foliar dissipation data to establish a
   decline curve.
5/ Only foliar dissipation data are required.

-------
                 TABLE A
GENERIC DATA REQUIREMENTS FOR NALED
Does EPA Have Data
To Satisfy This
I/ Use 2/ Requirement? (Yes, Bibliographic
Data Requirement Composition Pattern No or Partially) Citation
$158.145
Aquatic
Wildlife and
Organisms


Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/

AVIAN AND MAMMALIAN TESTING
71-1 -
71-2 -

71-3 -
71-4 -
71-5 -

Avian Oral LDso
Avian Dietary LC5Q
*
Wild Mammal Toxicity
Avian Reproduction
Simulated and Actual
Field Testing -
Mammals and Birds
TGAI A,B,C,D,G Yes
TGAI A,B,C,D, Yes
E,F,G,H,
I 4/
TGAI A,B,C,D,G No
TGAI A,B,CfD,G No
TEP A,B,C,D,G No

GS092099
00028757

-
-
-

No
No

No 5/
No 5/
No 5/

AQUATIC ORGANISM TESTING
72-1 -




Freshwater Fish 1X50


-do-

TGAI . A,B,C,D,
E,F,G,H,
I 4/ Yes
TEP C,D,G Partial

05003107
GS092101
GS092102
GS092101
GS092102
GS092017
No


Yes 6/


-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
Data Requirement
           I/   Use  2/
Composition   Pattern
            Does EPA Have Data
            To Satisfy This
            Requirement?  (Yes,
            No or Partially)	
                       Bibliographic
                         Citation
                  Must Additional
                  Data Be Submitted
                  Under FIFRA Section
                   3(c)(2)(B)?3/
§158.145 Wildlife and
 Aquatic Organisms
  (continued)

  72-2 - Acute LC5Q Freshwater       TGAI
          Invertebrates
              -do-                   TEP
              A,G,C,D,
              E,F,G,H,
              I       4/

              C,D,G
            Yes
            No
                       GS092100
                         No
                                                Yes 6/
  72-3 - Acute LC$Q Estuarine
          and Marine Organisms
    TGAI
C,D,G
Partially 7/
GS092104
00074684
Yes
  72-4 - Fish Early Life
          Stage and Aquatic
          Invertebrate Life-Cycle
   72-5 - Fish - Life-Cycle

   72-6 - Aquatic Organism
           Accumulation
   72-7 - Simulated or Actual
          Field Testing -
          Aquatic Organisms
    TGAI
    TGAI
TGAI, PAI OR
Degradation
  Product

    TEP
C,D,G



  CfD,G

  C,D,G
Reserved 8/



Reserved 9/

Reserved 9/
  C,D,G     Reserved 9/

-------
                                                      TABLE A
                                     GENERIC DATA REQUIREMENTS FOR NALED


  §158.145 Wildlife and Aquatic Organisms
           (continued)

\J Composition:  TGAI = Technical grade of the active ingredient; PAI = pure active ingredient;
   TEP = Typical end-use product;
2/ The use patterns are coded as follows:  A=Terrestrial, Food Crop; B=Terrestrial, Non-Food Crop; OAquatic, Food Crop;
   D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Dcmestic Outdoor; I=Indoor.
3/ Data must be submitted no later than	June 1986	•
4/ Only one species is required for the B,F,H and I use patterns.
5/ This data is not normally required.
6/ In addition to the technical, data must be submitted on unique formulations that are formulated for use in
   aquatic sites.
7/ In addition to the technical, testing is required for establishing the"acute toxicity of the technical pesticide to
   estuarine/marine invertebrates when the end-use product is expected to enter the estuarine or marine environment in
   significant concentrations because of its use or mobility patterns.  In the case of naled, it is used for mosquito
   control in estuarine marshes and swamps.  Studies will include 48 hour oyster embryo-larvae or 96 hour shell
   deposition, 96 hour juvenile shrimp and 96 hour estuarine finfish (spot or pinfish).  The available studies do
   not satisfy any of the guideline requirements and do not provide an adequate basis for assessing naled.  Since naled
   is very highly toxic to Daphnia, it is essential to conduct the appropriate tests on estuarine organisms.
8/ Reserved pending submission of appropriate environmental fate studies (e.g., hydrolysis) which are needed to
   determine the persistence of naled in the aquatic environment.
9/ Reserved pending submission of appropriate environmental fate studies (e.g., dissipation and hydrolysis studies)
   which are needed to determine if hazardous concentrations of 'naled will reach or accumulate in the aquatic environ-
   ments when products are used as directed.

-------
                                                        TABLE A
                                       . GENERIC DATA REQUIREMENTS FOR NALED
Data Requirements
Composition"
                                                          Does EPA Have Data
                                                          To Satisfy This
                                                  Use  2/ Requirement?  (Yes,
                                                Pattern   No or Partially)
Bibliographic
  Citation
Must Additional
Data Be Submitted
Under FIFRA Section
 3(c)(2)(B)?3/
S158.15Q Plant Protection

  121-1 - TARGET AREA                EP
           PHYTOTOXICITY

  NONTARGET AREA PHYTOIDXICITY

           TIER I
                j.

  122-1 - Seed Germination/         TGAI
          Seedling Emergence
                                                          No
                                                          No
                         No 4/
122-1
122-2
123-1
123-1
123-2
124-1
124-2
- Vegetative Vigor
- Aquatic Plant Growth
TIER II
- Seed Germination/
Seedling Emergence
- Vegetative Vigor
- Aquatic Plant Growth
TIER III
- Terrestrial Field
- Aquatic Field
TGAI
TGAI
TGAI
TGAI
TGAI
TEP
TEP
NO
No
No
No
No
No
No
No 4/
No 4/
No 4/
No 4/
No 4/
No 4/
No 4/
I/  Composition:  TGAI = Technical grade of the active ingredient; TEP = Typical end-use product.
    EP = End-use product.
2/  The use patterns are coded as follows:
    D=Aquatic, Non-Food; E=Greenhouse, Food
3/  Data must be submitted no later than _ .
4/  These requirements are generally waived unless it is believed there is a phototoxicity problem.
                                             A=Terrestrial, Food Crop; B=Terrestrial, Non-Food Crop;  C=Aquatic,  Food Crop;
                                             Crop; F=Greenhouse, Non-Food; G=Forestry; H=Doraestic Outdoor; I=Indoor.

-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FOR NALED
Data Requirement
           I/   Use  2/
Composition   Pattern
Does EPA Have Data
To Satisfy This
Requirement?  (Yes,
No or Partially)
Bibliographic
  Citation
Must Additional
Data Be Submitted
Under FIFRA Section
 3(c)(2)(B)?3/
§158.155 Nontarqet Insect

  NONTARGET INSECT TESTING -
  POLLINATORS;

  141-1 - Honey bee acute
           contact 11)50

  141-2 - Honey bee - toxicity
           of residues on
           foliage
    TGAI      A,B,G,H     Yes
    TEP       A,B,G,H     Yes
                       00036935
                       00060628
                       00037799
                       05000837
                         No
                         No
  141-3 - Wild bees iiqportant in     TEP
           alfalfa pollination -
           toxicity of residues
           on foliage

  141-4 - Honey bee subacute         TEP
           feeding study

  141-5 - Field testing for          TEP
           pollinators
              A4/
Yes   .
              A,B,G,H     Reserved 5/
              A,B,G,H     No
00060628
05000837
       No
                                                No 6/

-------
                                                        TABLE A
                                        GENERIC DATA REQUIREMENTS FDR NALED
                                                           Does EPA Have Data
                                                           To Satisfy This
                                                           Regu i rement?  (Yes,
                                                           No or Partially)
                       Bibliographic
                         Citation
Must Additional
Data Be Submitted
Under FIFRA Section
 3(c)(2)(B)?
§158.155 Nontarget Insect
         (continued)

  NONTARGET INSECT TESTING -
  AQUATIC INSECTS;

  142-1 - Acute toxicity to
           aquatic insects
                4.
  142-2 - Aquatic insect
           life-cycle study

  142-3 - Simulated or actual
           field testing for
           aquatic insects
  143-1 - NONTARGET INSECT
          TESTING - PREDATC
  thru    AND PARASITES

  143-3
Reserved T/


Reserved 7/


Reserved 7/
      •


Reserved 7/
  I/ Composition:  TGAI = Technical grade of the active ingredient; TEP = Typical end-use product.
  2/ The use patterns are coded as follows:  A=Terrestrial, Food Crop; B=Terrestrial, Non-Food;  OAquatic, Food Crop:
     D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
  3/ Data must be submitted no later than	;	.
  4/ Data required only for pesticides intended for foliar application to seed alfalfa.
  Ij/ Reserved pending development of test methodology.
  6/ May be required under the following conditions:
      i)   Data from the honey bee subacute feeding study (141-4) indicate adverse effects on colonies, especially
           effects other than  acute mortality (reproductive, behavioral, etc.);
      ii)  Data from residual toxicity studies (141-2 and 141-3) indicate extended residual toxicity; or
      iii  Data derived from studies with organisms other than bees indicate properties of the pesticide beyond acute
           toxicity such as the ability to cause reproductive or chronic effects.
  7/ Reserved pending decision as to whether data requirement should be established.

-------
                                                       TABLE B
               PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING NALED I/
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
2/ Requirement? (Yes, Bibliographic Under FIFRA Sectii
Data Requirement Composition No or Partially) Citation V 3(c)(2)(B)? V
§158.120
Product Chemistry


Product Identity:
61-1 -
61-2 -
61-3 -
Identity of Ingredients MP \ Yes
StatemenJ: of Composition MP Partial
Discussion of Formation of MP Partial
00074653
00074724
GS092040
00074653
00074791*
00065493; 00065494*
f\f\nr* 4s~r*>-*\ .jr-hnS*kS% *-k/"l A f\
NO
Yes 5/
Yes 6/
         Ingredients
                         00074653; GS092040
  Analysis and Certification of  Product
  Ingredients

  62-1  - Preliminary Analysis             MP
  62-2 - Certification of Limits         MP
  62-3 - Analytical Methods for          MP
          Enforcement of  Limits
  Physical and Chemical Characteristics

  63-2 - Color                           MP
Partial


Partial


Partial
Yes
00065493*; 00065494*;    Yes 6/
00074655; 00074653

00065493*; 00065494*;    Yes 7/
00074653

00065494*; 00074653       Yes 7/
00074655; 00074724
00074846; G5092006
00074790                 No
G5092040
"Data submitted by Chevron Chemical Company.  These data may be compensable.

-------
PRODUCT SPECIFIC DATA REQUIREMENTS
                                                      TABLE B
                                                 FOR MANUFACTURING-USE PRODUCTS CONTAINING NALED
2/
Data Requirement Composition
§158.120 Product Chemistry
63-3 -
63-4 -

63-7 -
63-12
63-14
63-15
63-16
63-17
63-18
63-19
63-20

Other
(continued)
Physical State MP
• Odor MP

»
• Density, Bulk Density, or MP
Specific Gravity
- pH MP
- Oxidizing or reducing MP
action
- Flamnability MP
- Explodability MP
- Storage Stability MP
- Viscosity MP
- Miscibility MP
- Corrosion MP

Requirements:
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
Requirement? (Yes, Bibliographic Under FIFRA Sectii
No or Partially) Citation 3/ 3(c)(2)(B)? V
Yes 00074790 No
G5092040
Yes 00074790 No
G5092040
Partial 00074653; 00074724 Yes 8/
00074790; G5092040
No - Yes
Yes' 00074790 No
Partial 00074790 Yes 9/
Yes- 00074790 No
Yes 00074653 No
Yes 00074790 No
GS092040
Yes 00074790 No
GS092040
Yes 00074790 No
GS092040

64- 1 - Submittal of samples
                          MP
No 10/

-------
                                                       TABLE B
               PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING NALED


 §158.120 Product Chemistry
          (continued)

 I/ Naled 90% technical is the only manufacturing-use product.
    The cited data may be used to satisfy the requirements for manufacturing-use naled manufactured by the process
    submitted by the Chevron Chemical Co. (00074653 and 00074791)  containing 90% naled (or similar percentages accepted
    on a product by product basis).
 2/ Composition:  MP = Manufacturing-use product.
 3/ All data cited were submitted by the Chevron Chemical Company.
 4/ Data'must be submitted no later than	npr  lqai	.
 5/ Adequate data has been submitted by the Chevron Chemical Company.  Other producers must address these data
    requirements.
 6/ The analytical methods used were inadequately described.  Identification and quantification of impurities
    present at >0.1% (W/W) is required.
 7/ There was a discrepancy of the limits.  An update of the manufacturing-use naled limits and quality control method
    (including validation data); adequate sampling (five or more production batches); and limit certification are required
 8/ The data are conflicting.  Clarification of the specific gravity of manufacturing-use naled is required.
 9/ The data are unclear.  Clarification of the flammability of the manufacturing-use naled is required.
10/ May be requested on a case-by-case basis.

-------
                                                        TABLE B
                PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING NALED
Data Requirement
Composition
                                                 I/
Does EPA Have Data
To Satisfy This
Requi rement?  (Yes,
No or Partially)
Bibliographic
  Citation
Must Additional
Data Be Submitted
Under FIFRA Section
 3(c)(2)(B)?2/
S158.135 Toxicology

  ACUTE TESTING

  81-1 - Oral LDso - Rat
  81-2 - Dermal LDso ~ Rabbit
  81-3 - Inhalation LC5n - Rat

  81-4 - Primary Eye
          Irritation - Rabbit

  81-5 - Primary Dermal
          Irritation - Rabbit

  81-6 - Dermal Sensitization -
         Guinea Pig
MP
MP



MP

MP


MP


MP
Yes
Yes



No

Yes


Yes


No
00049330
00074795
05016607
00065468

00074829*
00074663
00049330
GS092002
GS092001
GS092098
       No
       No



       Yes

       No


       No


       Yes 3/
  I/ Composition:  MP = Manufacturing-use product.
  2/ Data must be submitted no later than          Dec 1983
  3/ Data submitted to the Agency was conducted by Industrial Bio-Test Laboratories (IBT)  and has been determined to
     be invalid.
  *Data submitted by Chevron Chemical Company.  These data may be conpensable.

-------
   ... .,.-.:.. .-.••:..•: .  ..,-...,.    •..•....;•. ••'.-.  •/. ,• ' -• -•••• '.APPENDIX III -• 1- '•  '•
                 Guide  to Use  of This Bibliography


I. ••- CONTENT OF-^ 3I3LIOGRAP3Y.-  This bibliography contains" '"' '
    citations of  all stadias  considered relevant by  £?A  in
    arriving at the .positions and conclusions stated elsewhere
    in  the  Standard.   Primary sources for studies in this
    bibliography  have  been  the body of data submitted  to  2PA and
    its predecessor agencies  in support of past regulatory
    decisions.   Selections  from other sources including the
    published literature,  in  those instances where they have
    been considered, will  be  included.          .  .

2.' UNITS C? ENTRY.  The unit of entry in this bibliography is
    called  a 'study*.   In  the case of published materials,  this  •
    corresponds  closely to' an article.  In the- case of
    unpublished materials  submitted to the Agency, the Agency-
    has sought  to  identify  documents at a level parallel  to  the
    published article  from  within the typically larger volumes
    in which they  were  submitted.  The resulting 'studies'
    generally have a distinct title (or at least a single
    subject}, can  stand  alone for purposes  of review, and can  be
    described with a conventional bibliographic citation.  The .
    Agency  has  attempted also to unite basic documents and
    commentaries  upon  them, treating them as a single study.

3.  IDENTIFICATION OF  ENTRIES.-  The entries in'this bibliography
    are sorted  numerically  by 'Master Record Identifier*, or
    MSID, number.  This  number is unique  to the citation, and
    should  be used at  any time- specific reference is required.
    It is not related  to the  six-digit 'Accession Number' which
    has been used  to identify volumes of  submitted studies; see
    paragraph 4(d)(4)  below for a further explanation.   In a  few
    cases, entries added to the bibliography late in the review
    may be preceded by a nine-character temporary identifier.
    These entries  are  listed  after all MRID entries.   This
    temporary identifier number is also to  be used whenever
    specific reference is needed.

4. • FORM 0? ENTRY.  In addition to the Master Record  Identifier
    (MRID), each entry consists of a  citation containing
    standard elements  followed,  in the case  of  materials
    submitted to SPA, by a description of  the earliest  known
    submission.  Bibliographic  conventions  used  reflect the
    standards of the American National Standardq institute
    (ANSI), expanded to  provide for certain  special  needs.

    a.  •Author.  Whenever  the  Agency could  confidently identify
         one,  the Agency has  chosen  to show  a personal  author.
         When no individual was  identified,  the  Agency  has shown
         an identifiable laboratory  or testing  facility as
         author.  As a last resort,  the Agency has  shown  the
         first known submitter  as  author.

-------
b.    Document  Date.   When  the.date appears as four digits .
•• •-.••'•w-tta  no question marks,  the"Agency took it directly
      from  the "document.  When a four-digit data is followed
      by a  question sarfc, the  bibliographer deduced the date
      from  evidence in the  document.   When, the date appears. .
•••:-V •  as•{IS??')/..the  Agency was  unable to' determine or. :'. :
      estimate  the date of  the docuaent.

c.    Title.  In some cases it has  been necessary for Agency
      bibliographers  to create or enhance a document title.
      Any such  editorial  insertions are contained between
     'square brackets.

d.    Trailing  Parentheses. For studies submitted to the'
      Agency in the past, the  trailing parentheses include
      (in addition to any self-explanatory text)  the
      following elements describing, the earliest  Jcnovn
      submission:

      (1)   Submission Date. Immediately following the word
           'received*  appears  the date of the earliest known
           submission.

      (2)'   Administrative Number.  The next element,
           immediately following  the  word 'under',  is the
           registration number/  experimental permit number,
           petition number, or other  administrative number
           associated with  the earliest known submission.

      (3)   Submitter.   The  third  element is the  submitter/
           following  the phrase  'submitted  by'..   When
           authorship is defaulted  to the submitter, this
           element is omitted.
                                     i

      (4)   Volume Identification  (Accession Numbers).
           The  final  element in  the trailing parentheses
           identifies the SPA  accession number of the volume
           in which the original  submission of the  study
           appears.   The six-digit  accession- number follows
         'the  symbol 'COL1, standing for "Company  Data
           Library".   This  accession  number is in turn
         .  followed by an alphabetic  suffix which shows the  •
           relative position of  the study within,  the volume.
           For  example, within accession number  123456,. the
           first study  would be  123456-A; the second,  123456-
           8; the 26th  123456-2;  and  the 27th, 123456-AA.

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base
                     Registration Under the Standard
Supporting
00028757      Hill, E.F.; Heath, R.G.; Spann, J.W.; et al. (1975) Lethal Dietary
                 Toxicities of Environmental Pollutants to Birds.  By U.S. Fish
                 and Wildlife Service, Patuxent Wildlife Research Center.   Wash-
                 ington, D.C.: U.S. Fish and Wildlife Service.  (Special scienti-
                 fic report—wildlife no. 191; also in unpublished submission re-
                 ceived Apr 2, 1980 under 464-556; submitted by Dow Chemical
                 U.S.A., Midland, Mich.; CDL:242149-F)

00036935      Atkins, E.L.; Greywood, E.A.; Macdonald, R.L. (1975) Toxicity of
                 Pesticides and Other Agricultural Chemicals to Honey Bees: Labo-
                 ratory Studies.  By University of California, Dept. of Entomolo-
                 gy.   ?: UC, Cooperative Extension.  (Leaflet 2287; published
                 study.)

00037799      Johansen, C. (1961) Bee Poisoning Investigations, 1961: Report
                 No. 8577.  (Unpublished study received Mar 26, 1975 under 3125-
                 EX-119; prepared by Washington State Univ., submitted by Mobay
                 Chemical Corp., Kansas City, Mo.; CDL:094390-I)

00049330      Gaines, T.B. (1969) Acute toxicity of pesticides.  Toxicology and
                 Applied Pharmacology 14:515-534.  (Report no. 25529; also in
                 unpublished submission received Jul 15, 1976 under 3125-EX-135;
                 submitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:
                 226487-E)

00059386      Casida, J.E.; McBride, L.; Niedermeier, R.P. (1961) Metabolism of
                 0,O-Dimethyl 2,2-dichlorovinyl phosphate (Vapona (R)  or DDVP)
                 in Relation to Residues in Milk and Mammalian Tissues.  (Unpub-
                 lished study received on unknown date under unknown admin, no.;
                 prepared by Univ. of Wisconsin, Depts. of Entomology and Dairy
                 Husbandry, submitted by Shell Chemical Co., Washington, D.C.;
                 CDL:120596-C)

00060628      Johansen, C.A.; Eves, J. (1965) Bee Poisoning Investigations, 1965:
                 Report No. G-1705; Report No. 17338.  (Unpublished study, in-
                 cluding letter dated Jun 12, 1973 from C.A. Johansen to A.D. Co-
                 hick, received Mar 27, 1974 under 4F1485; prepared by Washington
                 State Univ., Dept. of Entomology, submitted by Chemagro Corp.,
                 Kansas City, Mo.; CDL:092011-I)

00064796      Pack, D.E. (1980) Mobility of Naled and Dichlorvos in Soil As De-
                 termined by Soil Thin-layer Chromatography: File No. 722.2.
                 (Unpublished study received Oct 20, 1980 under 239-1633; submit-
                 ted by Chevron Chemical Co., Richmond, Calif.; CDL:243547-A)

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
00065468      Berteau, P.E.; Deen, W.A.; Dirrmick, R.L. (1976) Studies of Effects
                 of Particle Size on the Toxicity of Insecticide Aerosals.  Final
                 rept.  By Univ. of California—Berkeley, Naval Biosciences Labo-
                 ratory for U.S. Dept. of the Array.   N.P.  (Contract no. MIPR-
                 5962; published study; CDL:229222-A)

00065493      Chevron Chemical Company (19??) Conposition of Technical Naled.
                 (Unpublished study received Mar 19, 1976 under 239-2444; CDL:
                 229289-F)

00065494      Hayman, E.L.; Friedrich, W.E.; Carlstrom, A.A. (1971) Determina-
                 tion of Impurities in Technical Dibrcm.  (Unpublished study
                 received Mar 19, 1976 under 239-2444; submitted by Chevron
                 Chemical Co., Richmond, Calif.; CDL:229289-H)

00072816      Dow Chemical U.S.A. (19??) Results of Tests on the Amount of Resi-
                 due Remaining, Including a Description of the Analytical Method:
                 Chlorpyrifos.  (Unpublished study received Mar 13, 1973 under
                 3F1370; CDL:093656-K)

00073815      Chevron Chemical Company (1971) Bromide Ion Residues Resulting from
                 the Use of Dibrcm (R)- (Naled) on Forage Crops.  (Compilation;
                 unpublished study, including test nos. T-2175 and T-2176, re-
                 ceived Sep 21, 1972 under OF0975; CDL:091678-A)

00073816      Chevron Chemical Company (1972)  Total Bromide Ion Levels in
                 Alfalfa, Pasture and Range Grass.  (Compilation; unpublished
                 study received on unknown date under OF0975; CDL:091678-B)

00073817      Chevron Chemical Company (1972)  Bromide Ion Concentrations of
                 Grapes Treated with Naled.  (Compilation; unpublished study
                 received on unknown date under OF0975; CDL:091678-C)

00073818      Chevron Chemical Company (1971)  Residue Data Sheets of Naled on
                 Alfalfa: Test No. T-2177.  (Compilation; unpublished study,
                 including test no. T-2178, received Aug 20, 1973 under OF0975;
                 CDL:091679-E)

00073819      Chevron Chemical Company (1971)  Residue Data Sheets of Naled on
                 Sugar Beets: Test No. T-2179.  (Compilation; unpublished study
                 received Aug 20, 1973 under OF0975; CDL:091679-F)
00073820      Chevron Chemical Company (1966) Dibrcm (R)  Naled: The Results of
                 Tests on the Amount of Residue Remaining Including a Description
                 of the Analytical Methods Used.  Includes residue methods RM-3
                 dated Jul 28, 1966, RM-3A dated Aug 18, 1966, RM-3C dated Aug
                 22, 1966 and RM-3E dated Aug 16, 1966.  (Compilation; unpub-
                 lished study received Sep 20, 1966 under 7F0532; CDL:090647-A)

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
00073821      Chevron Chemical Company (1970) Dibrom (R)  Naled: The Results of
                 Tests on the Amount of Residue Remaining Including a Description
                 of the Analytical Methods Used.  Includes methods RM-3 dated Jul
                 28, 1966, RM-3A dated Aug 18, 1966 and RM-3G dated Oct 31, 1969.
                 (Compilation; unpublished study received Mar 27, 1970 under
                 OF0975; CDL:091677-A)

00073830      Chevron Chemical Company (1974) Summary of Almond Residue Trials,
                 (Compilation; unpublished study received Apr 7, 1975 under
                 5F1614;  CDL: 094559-B)

00073846      Chevron Chemical Company (1970) Dibrom (R)  Naled: The Results of
                 Tests on the Amount of Residue Remaining, Including a Descrip-
                 tion of the Analytical Methods Used.  (Compilation; unpublished
                 study received on unknown date under 1F1078; CDL:093389-B)

00074643      Pack, D.E. (1976) Residues of Naled and DDVP in Aquatic Organisms
                 Living in Dibrom 14 Treated Water: File No. 721.11/Dibrom S-249.
                 Includes method RM-3G-3 dated Feb 23, 1973.  (Unpublished study,
                 including letter dated Mar 24, 1976 from J.B. Leary to Michael
                 L. Paulson, received Apr 8, 1976 under 1769-203; prepared by
                 Chevron Chemical Co., ^submitted by National Chemsearch, Div. of
                 NCH Corp., Irving, Tex.; CDL:224602-A)

00074644      Leary, J.B. (1974) Rate of Decay of Naled in Sewage Water: File
                 No. 721.2.  (Unpublished study received Dec 30, 1974 under 1769-
                 203; prepared by Chevron Chemical Co., submitted by National
                 Chemsearch, Div. of NCH Corp., Irving, Tex.; CDL:224603-B)

00074645      Leary, J.B.; Miesch, M.D., Jr. (1974) National Chemsearch Skychoda
                 Fate of Naled in a Sewage Treatment Plant: File No. 721.2.
                 (Unpublished study received Dec 30, 1974; May 12, 1976 under
                 1769-203; prepared by Chevron Chemical Co., submitted by Nation-
                 al Chemsearch, Div. of NCH Corp., Irving, Tex.; CDL:224603-C)

00074647      Chevron Chemical Company (1966) Analysis of Dibron (R)  Naled Resi-
                 dues by Acetylcholinesterase Inhibition: File 740.10.  Method
                 RM-3 dated Jul 28, 1966.  (Unpublished study received Sep 12,
                 1966 under 7F0532; CDL:092821-A)

00074653      Chevron Chemical Company (1966) Name, Chemical Identity and Compo-
                 sition of the Pesticide Chemical: Dibrom.  (Unpublished study
                 received Sep 12, 1966 under 7F0532; CDL:092821-H)

00074654      Chevron Chemical Company (1966) Naled: The Degradation and Metabol-
                 ic Fate in Biological Media.  Rev.  (Unpublished study received
                 Sep 12, 1968 under 7F0532; CDL:092821-1)

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
00074655      Chevron Chemical Company (1966) Ortho Method of Analysis—D-DC-a:
                 Dibrcm (R)  Naled by Gas Chromatograph.  Method dated May 27,
                 1966.  (Unpublished study received Sep 12, 1966 under 7F0532;
                 CDL:092821-J)

00074656      Schwartz, C.S.; Cox, G.E.; Stevens, K.R. (1978) The Evaluation of
                 Dibrcm as a Potential Neurotoxic Agent following Oral Adminis-
                 tration to Hens Protected by Atropine Sulfate: Laboratory
                 No. 5981.  (Unpublished study received Dec 21, 1978 under 239-
                 1633; prepared by Food and Drug Research Laboratories, Inc.,
                 submitted by Chevron Chemical Co., Richmond, Calif.; CDL:
                 236682-A)

00074663      Elsea, J.R. (1958) Acute Dermal Application.  Rev.  (Unpublished
                 study received Sep 20, 1966 under 7F0532; prepared by Hazleton
                 Laboratories, submitted by Chevron Chemical Co., Richmond,
                 Calif.; CDL:090644-E)

00074684      Chevron Chemical Company (1960) Toxicology Reports: Dibron in Oys-
                 ters.  (Compilation; unpublished study received Sep 20, 1966
                 under 7F0532; CDL:090646-N)
                                       *           *
00074691      Leary, J.B. (1971) Rate of Hydrolysis of Naled in Aqueous Solution:
                 File No. 721.2.  (Unpublished study received Jul 30, 1971 under
                 1F1111; submitted by Chevron Chemical Co., Richmond, Calif.;
                 CDL:090881-A)

00074692      Chevron Chemical Company (1971?) Description of a Residue Test (T-
                 2360) To Determine Bromide Ion Residues in Poultry Tissue and
                 Eggs following the Application of Ortho Fly Killer D (36% Naled)
                 in Poultry Houses and on Laying Hens: File No. 741.11.  (Unpub-
                 lished study received Mar 4, 1972 under 1F1111; CDL:090881-B)

00074699      Kohn, G.K. (1959) Letter sent to G.S. Hensill dated Dec 16, 1959:
                 Dibrcm residues—pole beans.  (Unpublished study received Jan
                 14, 1960 under 239-1281; submitted by Chevron Chemical Co.,
                 Richmond, Calif.; CDL:119766-A)

00074700      Chevron Chemical Company (1965) Dibrcm Residues in Spinach, Grain
                 Sorghum and Cotton.  (Compilation; unpublished study received
                 Jul 9, 1965 under unknown admin, no.; CDL:124538-A)

00074721      Chevron Chemical Company (1957?) Analysis of Dibrcm Residues.
                 Undated method RM-III.  (Unpublished study received Feb 19, 1958
                 under unknown admin, no.; CDL: 119738-A)

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
00074722      Kohn, G.K. (1958) Letter sent to G.S. Hensill dated Feb 14, 1958:
                 Dibrcm residues.  (Unpublished study received Feb 19, 1958 under
                 unknown admin, no.; submitted by Chevron Chemical Co., Richmond,
                 Calif.; CDL:119738-B)

00074723      Chevron Chemical Company (1964) Residue Data Sheets: Dibrom in
                 Rice: Test No. T-508.  (Compilation; unpublished study, includ-
                 ing test nos. T-551 and T-544, received Mar 12, 1965 under un-
                 known admin* no.; CDLsll9745-F)

00074724      Ospenson, J.N. (1958) Letter sent to G.K. Kohn dated Feb 4, 1958:
                 Dibrom—physical and chemical properties.  Includes method dated
                 Apr 3, 1957.  (Unpublished study received Feb 10, 1958 under un-
                 known admin, no.; submitted by Chevron Chemical Co., Richmond,
                 Calif.; CDL:119717-A)

00074725      Chevron Chemical Company (19??) Proof of Recovery of Dibrom from
                 Fortified Crop Extracts Utilizing Standard Procedure.  (Unpub-
                 lished study received Jan 23, 1959 under unknown admin, no.;
                 CDL:119737-A)

00074728      Sessions, A.; Pack, D.E. (1959) Residue Data Sheet: Grapes: Test
                 No. T-76.  (Unpublished study received Jan 23, 1959 under un-
                 known admin, no.; submitted by Chevron Chemical Co., Richmond,
                 Calif.; CDL:119737-D)

00074729      Wegenek, E.G.; Pack, D.E. (1959) Residue Data Sheet: Beans: Test
                 No. T-87.  (Unpublished study received Jan 23, 1959 under un-
                 known admin, no.; submitted by Chevron Chemical Co., Richmond,
                 Calif.; CDL:119737-E)

00074759      Leary, J.B. (1970) Decomposition of Naled and DDVP in Soils: File
                 No. 721.2.  (Unpublished study received Nov 27, 1970 under un-
                 known admin, no.; submitted by Chevron Chemical Co., Richmond,
                 Calif.; CDL:120336-A)

00074790      Chevron Chemical Company (1965?) Product Chemistry Data for Chevron
                 Naled Technical.  (Unpublished study received Oct 17, 1977 under
                 239-1633; CDL:232095-A)

00074791      Chevron Chemical Company (19??) Naled (l,2-Dibromo-2,2-dichloro-
                 ethyl Dimethyl Phosphate): Manufacturing Process.  (Unpublished
                 study received Oct 17, 1977 under 239-1633; CDL:232095)

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
00074795      Chevron Chemical Company (19??) Acute Oral Toxicity—Albino Rats:
                 Sunraary of Reactions.  (Unpublished study received Feb 2, 1959
                 under 239-1280; CDL:050010-D)

00074806      California Chemical Company (1961) Project Report—Dibrom Residue:
                 Analytical Procedures: File 740.10.  (Unpublished study received
                 Feb 21, 1963 under PP0330; CDL:090359-D)
         /
00074807      Ospenson, J.N. (1963) Letter sent to G.K. Kohn dated Feb 14, 1963:
                 Dibrom and metabolite residue studies on oranges and lettuce.
                 (Unpublished study received Feb 21, 1963 under PP0330; submitted
                 by California Chemical Co.,' Richmond, Calif.; CDL:090359-I)

00074817      Weir, R.J. (1958) Final Report: Subacute Feeding—Rats.  (Unpub-
                 lished study received Feb 13, 1959 under 239-1281; prepared by
                 Hazleton Laboratories, submitted by Chevron Chemical Co.,
                 Richmond, Calif.; CDL:050424-D)

00074829      Narcisse, J.K.; Cavalli, R.D. (1971) Acute Dermal Toxicity of Naled
                 Technical and Dibrcm 8E: SOCAL 212/VI:41 (S-293).  (Unpublished
                 study received Jan 4, 1974 under 239-1281; submitted by Chevron
                 Chemical Co., Richmond:, Calif.; CDL:050854-A)

00074836      California Chemical Company (1960) Sunmary of Typical Dibrom Resi-
                 due Data in This Petition.  (Compilation; unpublished study re-
                 ceived Sep 1, 1961 under PP0330; CDL:090357-J)

00074843      Ives, M. (1962) Report to Ortho Division—California Chemical Com-
                 pany: Demyelination Studies in Chickens—Dibrom.  (Unpublished
                 study received Aug 20, 1962 under PP0330; prepared by Industrial
                 Bio-Test Laboratories, Inc., submitted by California Chemical
                 Co., Richmond, Calif.; CDL:090358-G)

00074844      Casida, J.E.; McBride, L.; Niedermeier, R.P. (1961) Metabolism of
                 0,0-Dimethyl 2,2-Dichlorovinyl Phosphate (Vapona (R) or DDVP)
                 in Relation to Residues in Milk and Mammalian Tissues.  (Unpub-
                 lished study received Aug 20, 1962 under PP0330; prepared by
                 Univ. of Wisconsin, Depts. of Entomology and Dairy Husbandry,
                 submitted by California Chemical Co., Richmond, Calif.; CDL:
                 090358-H)

00074845      Chevron Chemical Company (1973) Summary and Data on Residues of
                 Naled in Cotton and Safflower.  (Compilation; unpublished study
                 received Jan 9, 1974 under 1F1078: CDL:093391-A)

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
00074846      Chevron Chemical Company (1964) Analysis of Dibrom.  Method dated
                 Jul 21, 1964.  (Unpublished study received Jun 23, 1965 under
                 unknown admin, no.; CDL:102845-A)

00074862      Weir, R.J. (1958) Final Report: 90-day Oral Administration—Dogs.
                 (Unpublished study received Jun 12, 1958 under unknown admin.
                 no.; prepared by Hazleton Laboratories, submitted by Chevron
                 Chemical Co., Richmond, Calif.; CDL:102887-A)

00074885      Chevron Chemical Company (1969) Analysis of Naled and DDVP Resi-
                 dues: File No. 740.01.  Method RM-3G dated Oct 31, 1969.  (Un-
                 published study received Nov 30, 1970 under OF0975; submitted
                 by Chevron Chemical Co., Richmond, Calif.; CDL:095468-A)

00075668      Chevron Chemical Company (1961) Residue of Dibrom on the Tomato
                 and Cucumber: CSC-513 No. 502-6.  (Compilation; unpublished
                 study, including report nos. CSC-513 no. 502-5, CSC-513 no.
                 502-4, CSC-513 no. 502-2 and CSC-513 no. 502-3, received Jul 24,
                 1961 under 239-1466; CDL:119776-A)

05000837      Johansen, C.A. (1972) Toxicity of field-weathered insecticide
                 residues to four kinds of bees.  Environmental Entomology
                 K3)s393-394.

05003107      Macek, K.J.; Hutchinson, C.; Cope, O.B. (1969) The effects of
                 temperature on the susceptibility of bluegills and rainbow
                 trout to selected pesticides.  Bulletin of Environmental
                 Contamination and Toxicology 4(3):174-183.

05016607      Brzezicka-Bak, M.; Bojanowska, A (1969) Toksycznosc Pcdostra
                 insektycdow fosforoorganicznych: naledu, etoatu metylowego i
                 supracidu  Subacute toxicity of the organophosphorus
                 insecticides naled, methyl ethoate and supracide Roczniki
                 Panstwowego Zakladu Higieny.  Annals of the Polish Institute
                 of Hygiene.  XX(4):463-469.

-------
                      OFFICE OF PEST5ICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the standard
GS092001   Bullock, C. H. and J. K. Narcisse.  1975.  The skin irritation
              potential of Dibron-14 Concentrate (CC 5511).  Study No.
              S-741, Standard Oil Company of California, SOCAL 659/XX:115,
              November 19, 1974.

GS092002   Bullock, C.H., and J.K. Narcisse.  1975.  The eye irritation
              potential of Dibrcm-14 Concentrate (CC 5511).  Study No.
              S-742, Standard Oil Company of California, SOCAL 659/XX:114,
              November 19, 1974.

GS092006   Carlstrcm, A.A. 1975.  Gas-liquid chronatographic determination
              of naled in pesticide formulations.  JAQAC 58(6):1162-1168.

GS092017   Dean, H.J, J.R. Colquhoun, H.A. Sincnin. 1977. Toxicity of
              Methoxychlor and Naled to Several Life Stages of Landlocked
              Atlantic Salmon.  N.Y. Fish and Game J. 24:144-153.

GS092026   California Spray-Chemical Corporation.  1959.  14-Day milk
              residue study - dairy animals.  Unpublished study prepared
              by Hazelton Laboratories for Chevron Spray Chemical Cor-
              poration, and submitted under 1F1111.

GS092040   Chevron Chemical Company.  1966.  Name, Chemical Identity and
              Composition of the Pesticide Chemical: Dibron.  (Unpub-
              lished study received Oct 22, 1974 under 239-163,
              Accession No. 233083).

GS092090   Chevron Chemical Company.  1981.  [Ethyl-l-l4C]|Naled Plant
              Metabolism.  Pages 6-30 In Metabolism chemistry data for
              Chevron Naled Technical.  (Received Oct. 14, 1981 under
              unknown admin, no.)

GS092091   Casida, J.E., L. McBride, and R.P. Niedermeier.  1962.  Metab-
              olism of 2,2-^ichlorovinyl dimethyl phosphate in relation
              to residues in milk and mammalian tissues.  J. Agric. Food
              Chem.  10:370-377.

GS092092   Chen, Y.S., 1981.  Metabolism of (Ethyl-l-l^C] Naled in a
              Lactating Goat.  Unpublished study received March 4, 1982,
              under 239-1633; submitted by Chevron Chemical Company,
              Richmond, California.

GS092093   Chevron Chemical Company.  1969.  Naled residues in mushrooms.
              Unpublished study prepare by Green Giant Co., and submitted
              under 1E1100 by Chevron Chemical Company.

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
GS092094   Lynn, G.E. et aJL.  1962?  Studies of the Occurrence of Bromides
              in the Milk of Cows Fed Sodium Bromide and Grain Fumigated
              with Methyl Bromide.  Study received Jan. 8, 1962, under
              Pesticide Petition No.  345; submitted by The Dow Chemical
              Co., Midland, Michigan.

GS092095   Chevron Chemical Company.  1970.  Naled pasture and milk
              residue study.  Unpublished study submitted under OF0975.

GS092096   Getzendaner, M. E., 1963.  A study of Bromide Residues in
              Chicken Tissues and Eggs from Ingestion of Methyl Bromide
              Fumigated Feed.  Study received June 5, 1963, under Pesti-
              cide Petition No. 345; submitted by the Dow Chemical Company.,
              Midland, Michigan.

GS092097   Lough, R.L., P. Batham, C. Bier, B. Legg, P. Aranjo, J. W.
              Hooper, B. Broxup, B. E. Osborne, and B. G.  Proctor.
              1981.  DIBROMR:  Four week subchronic oral toxicity
              study in rats.  (Conducted by BioResearch Laboratories,
              Ltd., 87 Senneville Rd., Senneville, Quebec H9X 3R3, Canada,
              for Chevron Chemical (Canada) Ltd., 3228 South Service
              Rd., Burlington, Ontario_L7N 3H8, Canada.  Unpublished
              report.  EPA Accession No. 246496.)

GS092098   Phillips, L., Steinberg, M., Maibach, H. I., and Akers, W.A.
              1972.  Comparison of rabbit and human skin response to
              certain irritants.  Toxicol. Appl.  Pharmacol. 21^369-382.

GS092099   Tucker, R.K. and P.G. Crabtree.  1970.  Handbook of Toxicity of
              Pestsicides to Wildlife.  Bur. Sport Fisheries and Wildlife,
              DWRC, Fish and Wildlife Service, USDI.  Publ. 84.

GS092100   Wheeler, R.E. 1972.  48 Hour Acute Static Toxicity of Naled
              (SX820) to  1st Stage Nymph Water Fleas (Daphnia magna Straus).
              (Unpublished ??).

GS092101   USEPA.  1977.  Biological Report of Analysis.  Static Jar Test
              No. 1061.  Animal Biology Laboratory,  Jan 13, 1977.
              (Unpublished).

GS092102   USEPA.  1971.  Fish toxicity laboratory report.  Test No. 304.
              Animal Biology Laboratory, May 11-17, 1971. (Unpublished).

GS092103   Shiau, S.T., R.A. Huff, and I.C. Felkner.  1981.  Pesticide
              mutagenicity in Bacillus subtilis and Salmonella typhimurium
              detectors.  J. Agric. Fd. Chenu 29:268-271.

GS092104   Haskin, H. and R.G. Haines.  1960.. Fish and Wildlife Toxicity
              Report.  Chevron Chemical Co.  OR-513, No. 241-36-38.
              August 31, 1960.

-------