GUIDANCE FOR THE
REREGISTRATION OF MANUFACTURING-USE
AND CERTAIN END-USE PESTICIDE PRODUCTS
CONTAINING
CARBOPHENOTHION
(058102)
May 1984
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20460
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TABLE OF CONTENTS
Introduction 1
I. Regulatory Position 4
II. Requirement for Submission of Generic Data 22
III. Requirement for Submission of Product-Specific
Data 25
IV. Submission of Revised Labeling and Packaging
Information 26
A. Label Contents 26
1. Product Name 26
2. Company Name and Address 26
3. Net Contents 26
4. Product Registration Number 27
5. Producing Establishment
Registration Number 27
6A Ingredient Statement 27
6B Pounds Per Gallon Statement 27
7. Front Panel Precautionary Statements 27
7A Child Hazard Warning Statements 27
7B Signal Word 28
7C Skull and Crossbones and Word Poison 28
7D Statement of Practical Treatment 28
7E Referral Statement 28
8. Side/Back Panel Precautionary Labeling .... 28
8A Hazard to Humans and Domestic Animals 29
8B Environmental Hazard 29
8C Physical or Chemical Hazard 29
9. Product Classification 29
10. Misuse Statement 30
11A Storage and Disposal Block 34
11B Directions for Use 34
B. Collateral Information 34
V. Instructions for Submission 35
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APPENDICES
Bibliography II-l
FIFRA §3(c)(2)(B) Summary Sheet -
EPA Form 8580-1 II-2
Certification of Attempt to Enter Into an
Agreement With Other Registrants for Development
of Data EPA Form 8580-6 II-3
Product Specific Data Report (End-Use Products)... III-l
Sample Label Formats IV-1
Table of Labeling Requirements IV-2
Physical/Chemical Hazards Labeling Statement IV-3
Storage and Disposal Instructions IV-5
Note: Appendices IV-4 and IV-6 are not germane to this
document and are not included.
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INTRODUCTION
The Federal Insecticide, Fungicide, and Rodenticide Act
(FIFRA Section 3(g), as amended in 1978, directs EPA to
reregister all pesticides as expeditiously as possible. Each
registrant of a manufacturing use product of the active
ingredient who wishes to continue to sell or distribute that
product must apply for reregistration.
To fulfill this Congressional mandate, we have established
the Registration Standards program which will review all pesti-
cide active ingredients first registered before January 1,
1977. These pesticides will be reviewed in use clusters
which are prioritized on the basis of a ranking scheme giving
preference to pesticides used on food and feed crops.
The Registration Standards program involves a thorough
review of the scientific data base underlying pesticide
registrations and an identification of essential but missing
studies which may not have been required when the product
was initially registered or studies that are now considered
insufficient. Our reassessment results in the development
of a regulatory position, contained in this document, on
each pesticide and its uses. The regulatory position may
require the registrant to modify product labels to provide
additional precautionary statements, restrict the use of the
pesticide to certified applicators, provide reentry intervals,
modify uses or formulation types, specify certain packaging
limitations, or other requirements to assure that proper use
of the pesticide poses no potential adverse effects to human
health or the environment.
The scientific review, which is not contained herein
but is available upon request, concentrates on the technical
grade of the active ingredient and identifies missing generic
data. However, during the review of these data we are also
looking for potential hazards that may be associated with
the formulated (end-use) products that contain the active
ingredient. If we find serious concerns, we will bring
formulated products under the provisions of the Registration
Standards program to the extent necessary to protect the
public.
EPA has the authority under FIFRA §3(c)(2)(B) to require
that certain registrants submit generic data that will answer
our questions regarding the hazard that may result from the
intended use of the pesticide under review. Further, §3(c)
(2)(B) provides that these data are to be submitted by
those registrants who do not qualify for the formulator's
exemption [FIFRA §3(c)(2)(D)]. Normally, this means that
the registrants who are responsible for filling the data
gaps are the manufacturing-use product producers (basic
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suppliers of the active ingredient). However, end-use producers
will not qualify for the formulator's exemption if the source
of their active ingredient: (1) is not registered with EPA,
and/or (2) is produced by the registrant's firm, or a firm
which has ownership in common with the registrant's firm.
These end-use producers can qualify for the formulator's
exemption if they change their source of supply to a- registered
source, provided the source does not share ownership in
common with the registrant's firm. If the end-use product
registrant decides to switch sources, a new Confidential
Statement of Formula, EPA Form 8570-4, must be submitted to
the appropriate Product Manager within 90 days of receipt of
this Guidance Document. The chart on the following page
shows what is generally required of those who do and do not
qualify for the formulator's exemption in the Registration
Standards program.
If you decide to request the Agency to discontinue the
registration of any of your products subject to the reregistra-
tion requirements of this Guidance Document, please notify
the Product Manager named in the cover letter, within 90
days from the receipt of this document, that you wish to
voluntarily cancel the registration(s). If you decide to
maintain your product registration(s), you must provide the
information described in the following pages within the time-
frames outlined. EPA will issue a notice of intent to cancel
or suspend the registration of any currently registered
product if you fail to comply with the requirements set
forth in this Guidance Document.
This Guidance Document will be supplemented by EPA with
additional information about compliance with data support
requirements. In Monsanto v. Administrator, EPA was recently
enjoined from implementing in any way the "mandatory data
licensing" aspects of §3(c)(l)(D) of FIFRA. EPA is assessing
the implications of the injunction for the reregistration
process. Because this situation is currently unresolved, EPA
has decided to proceed with the requirements in this Guidance
Document which do not relate to compliance with the §3(c)(l)(D)
provisions and to supplement the Document with additional
guidance when circumstances permit. Failure to comply with
the provisions of the subsequent guidance will also result
in issuance by EPA of an intent to cancel the affected product
registration(s).
Registrants are reminded that §6(a)(2) of FIFRA requires
you at any time to submit factual information raising concerns
of possible unreasonable adverse effects of a pesticide. You
should notify the Agency of interim results of studies in
progress if those results show possible unreasonable adverse
effects.
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PRODUCTS SUBJECT TO THE
REGISTRATION STANDARDS PROGRAM
ACTION(S) REQUIRED TO
MAINTAIN REGISTRATION
I. Products That Do Not Qualify
For The Formulator's Exemption
A. Single Active Ingredient
Products*
These products must be reregis-
tered. To obtain reregistration,
labeling, packaging and data
requirements must be satisfied
in accordance with the Regis-
tration Standards Guidance
Document.
B. Multiple Active Ingredient
Products
These products will not be
reregistered at this time.
However, generic data required
to continue the registration of
the active ingredient under
review, as described in the
Registration Standards Guidance
Document, will be required and
some labeling precautions may
also be required.
II. Products That'Do Qualify For
The Formulator's Exemption
Only when additional restric-
tions or labeling are needed to
protect man or the environment
will these products be subject
to the Registration Standard
requirements. Affected products
will be dealt with in a variety
of ways, including but not
limited to the Label Improvement
Program and special intent
to cancel notices.
* End-use products of registrants who also produce a manufacturing-
use product will not be required to be reregistered provided that
registrant fulfills the requirements specified in the Guidance
Document for manufacturing-use product(s). Such end-use products
will be subject to the labeling changes required for products in "II"
above. If there are no manufacturing-use products registered by any
company end-use products will be required to be reregistered.
NOTE: If all registrants in "I" above fail to meet the requirements in
I-A and B above, then the registrants in "II" lose their right to
qualify for the formulator's exemption and become subject to the
requirements in I-A and B.
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II. REGULATORY POSITION AND RATIONALE
A. INTRODUCTION
This Guidance Document describes the Agency's regulatory
position on registered manufacturing-use products (MPs)
containing the insecticide carbophenothion. This Guidance
Document also addresses certain labeling requirements for
end-use products. This position is based on a consideration
of all accepted uses of pesticide products containing carbo-
phenothion as the sole active ingredient, under sections 3
and 24(c) of the FIFRA. Other considerations include the
known chemical, environmental, and toxicological characteris-
tics of this pesticide and the established tolerances for
residues in or on food and feed commodities. From these
considerations the Agency sets forth the data and labeling
requirements that must be met by registrants and applicants
of carbophenothion products in order for a product to be
registered or reregistered under this Document. Only those
registration and labeling requirements for current and
future substantially similar MPs and EP's are addressed
here. Future products that differ appreciably from those
described in this Document may require that amendments be
made to this Document to reflect the differences.
B. CHEMICAL DESCRIPTION AND USE PROFILE
Carbophenothion is the acceptable common name for the insecti-
icide S-[[(p-chlorophenyl)thio]methyl] 0,0-diethyl phosphoro-
dithioate as determined by the American National Standards
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Institute (ANSI). The Chemical Abstracts Registry (CAS) number
is 786-19-6, and the EPA Chemical Reference Number is 058102.
Stauffer Chemical Company is the sole producer of carbopheno-
thion in the United States and markets its products under the
trade name Trithion®.
Technical carbophenothion is a yellow-brown liquid with a mild
mercaptan-like odor. The empirical formula is CnHi6C102PS3
and the molecular weight is 342.9. Physical and chemical
properties of technical carbophenothion are: vapor pressure
0.008 u at 25°C; solubility in water 0.34 ppm at 20°C; specific
gravity 1.274 at 20°C; pH 2.43; and boiling point 82°C at
0.01 mmHg. Carbophenothion is miscible with most organic
solvents such as petroleum ether, benzene, toluene, xylene,
ethers, alcohol and ketones. [GS0108092, GS0108093,
GS0108094]
There are three federally EPA registered manufacturing-use
products and thirty federally registered end-use products
containing carbophenothion as the sole active ingredient.
In addition, there are thirty-two EPA registered multiple-
active ingredient products containing carbophenothion in
combination with azinphos-methyl, captan, carbaryl, difocol,
endolsulfan, sulfur and thiram. There are only two Section
24(c) "Special Local Need" registrations.
Carbophenothion is an organophosphorus acaricide and insecticide
registered for use on a wide variety of vegetable, fruit, nut,
forage, ornamental, and forestry sites. The majority of
pesticide use in this country is on citrus. Carbophenothion
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is commercially available as dust, granular, pelleted, wettable
powder, and emulsifiable concentrate formulations. Most
products are applied as foliar applications using either ground
or aerial equipment. Dormant and delayed dormant applications
are made to some fruit and nut trees. There are also limited
uses as a seed treatment, dip, and soil insecticide. Most agri-
cultural product labels specify that use should be only by
trained personnel, using proper protective equipment.
C. REGULATORY POSITION
Based on a review and evaluation of all available data and
other relevant information on carbophenothion, the Agency has
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made the following determinations:
1. The Agency has identified concerns over the potential
adverse effects of carbophenothion to aquatic and terrestrial
species. Based on acceptable aquatic acute toxicity
studies, it is calculated that the expected concentration
of carbophenothion following direct application to a
6-inch layer of water exceed 1/2 the acute toxicity level
in aquatic species. Based on a scientifically sound
subacute dietary study, it is calculated that the expected
residues in avian foodstuffs following a single application
of carbophenothion at a rate of 1 pound a.i. per acre
exceed 1/5 the subacute dietary toxicity in avian species.
In. addition, although there is insufficient information
on the granular formulations, the Agency expects that
granular applications of carbophenothion would have an
adverse impact on birds.
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A total risk assessment cannot be made until gaps in the
data base for terrestrial species and environmental fate
are filled. After the Agency has evaluated these data, it
will determine whether EPA should initiate a public interim
review process by placing the chemical in Special Review.
If instead, regulation of the chemical through the normal
registration process is found to be appropriate, the Agency
will update its regulatory position and rationale to reflect
this conclusion and the reasoning behind it. In the interim,
precautionary label statements listed in Section G of this
document are required to reduce the hazards.
2. The Agency is unable to complete a full tolerance reassess-
ment of carbophenothion because of extensive residue chemistry
and toxicology data gaps. Future requests for tolerances
will not be automatically rejected, but will be considered
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on a case-by-case basis.
3. California has established reentry intervals for carbo-
phenothion of 14 days for citrus, peaches, nectarines, and
grapes; and 2 days for all the other crops. A federal
reentry interval of 2 days for carbophenothion has been
established for all crops under 40 CFR 170. The Agency
will continue to require a reentry interval of 2 days for
crop uses of carbophenothion pending the receipt and evalua-
tion of reentry data. The Agency is also requiring an
interim 24 hour reentry interval for the outdoor domestic
use on lawns and ornamentals.
4. The Agency has determined that all end-use products contain-
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ing carbophenothion warrant restricted use. Registrants
will have the option of accepting the restricted-use
classification, or submitting data as specified in
Table C. PRODUCT SPECIFIC DATA REQUIREMENTS FOR END-USE
PRODUCTS.
5. Additional label precautions that must be included on the
labeling for carbophenothion products have been identified.
These precautions can be found in Section G of this Document.
6. Manufacturing-use pesticide products containing carbo-
phenothion as a sole active ingredient may be registered
for sale, distribution, reformulation, and use, subject
to the terms and conditions specified in this Guidance
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Document.
7. Registrants must provide or agree to develop additional
data, as specified in the tables, in order to maintain
existing registrations and to permit new registrations.
D. REGULATORY RATIONALE
The Agency has determined that it should continue to allow
the registration of carbophenothion after considering the
following:
1. Adequate studies are unavailable to assess the acute
toxicological effects of carbophenothion to humans.
Preliminary data indicate that carbophenothion is in
Toxicity Category I on the basis of acute oral and dermal
effects [00089847, GS010097]. Once data gaps are filled,
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precautionary label statement requirements associated with
assigned toxicity categories for acute toxicity (oral, dermal,
inhalation, and irritant effects) should minimize the acute
hazards associated with these routes of exposure. Carbophenothion
is not adequately tested for chronic toxicity, oncogenicity or
teratology.
2. Based on studies available to assess hazards to terrestrial
and aquatic organisms, carbophenothion is characterized as very
highly toxic to freshwater and marine /estuarine organisms and
highly toxic to upland gamebirds. Label precautions required
by this Guidance Document should reduce the hazard to terrestrial
and aquatic organisms. Once data gaps are filled, additional
labeling precautions may be required. Independent of the Regis-
tration Standards process, groups of chemicals are being reviewed
by EPA and the Office of Endangered Species for possible impacts
on endangered species. Carbophenothion is being reviewed along
with other pesticides used on corn, cotton, soybean, and sorghum
as part of this cluster approach. Additional label requirements
may be imposed as a result of this review.
3. Available data are insufficient to assess the environmental
fate of carbophenothion or to assess the potential exposure
of humans and non-target organisms to carbophenothion.
Preliminary data indicate that carbophenothion is relatively
immobile in sandy loam soils. However, the Agency cannot
assess the potential for carbophenothion to contaminate
groundwater until leaching data are submitted. Preliminary
data indicate that there may be a potential for carbophenothion
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to accumulate in spot and juvenile sheepshead minnows.
Once the additional studies requested in Table A of this
Guidance Document are filled, an environmental fate
assessment can be made.
4. Based on residue chemistry and toxicology considerations,
there is no evidence to suggest that current tolerances
are likely to expose the public to unreasonable adverse
effects.
5. Because carbophenothion is a very acutely toxic pesticide,
and until data are submitted to evaluate the hazards of
worker exposure to treated crops, the Agency is requiring
a 48 hour crop reentry interval to appear on the labeling
of all end-use agricultural products.
The Agency is also concerned about the outdoor domestic
use on lawns, and the outdoor domestic use on ornamentals
by professional applicators, since there is a possibility
of post-application exposure to individuals and pets
from these uses. However, the amount of exposure cannot
be determined because of numerous data gaps. Since dermal,
eye, and inhalation exposure from both the granular and
emulsifiable concentrate formulations can occur to applicators
and residents, the Agency is requiring an interim 24
hour reentry interval until data are submitted to enable
the Agency to evaluate the hazards from these uses.
6. The Pesticide Incident Monitoring System (PIMS) reports
covering the period from 1966 to January 1980 include
11 incidents involving the pesticide carbophenothion.
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The human and domestic adverse effects reported in these
incidents were the result of improper handling and inges-
tion of carbophenothion or food contaminated with carbo-
phenothion.
7. Until recently, classification decisions for previously
registered products have been made through regulation.
The Agency has stated that its preferred method for
classification is through the reregistration procedure.
Consideration of classification during the reregistration
process enables the Agency to thoroughly evaluate the
risks/benefits of a restricted use classification and is
a more efficient use of Agency resources.
Classification considerations are based on the toxicity
categories in §162.11(c). The principal human effects
•
triggers for pesticides used in non-domestic settings are the
Toxicicity I criteria, i.e. acute dermal toxicity 200 mg/kg or
less; acute inhalation toxicity 0.2 mg/1 or less and acute
oral toxicity 50 mg/kg or less. The principal human effects
triggers for pesticides in the domestic settings are the
Toxicity II criteria. Following the identification of
candidates based on these criteria, §162.11(c) calls for
an evaluation of label adequacy. If certain subjective
criteria are met that indicate current label language or
new label language could be developed to prevent unreason-
able adverse effects, then the formulation/use in question
could be classified general use. An evaluation of other
information such as human toxicological data, accident
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data, or monitoring data is also required under §162.11(c).
The acute toxicology data base for carbophenothion end-use
products is severely lacking. Current carbophenothion
product labels carry Toxicity Category I, II, and III
designations. Technical carbophenothion is in Toxicity
Category I on the basis of an acute dermal toxicity of 27
mg/kg to female rats and 54 mg/kg to male rats [GS010097].
Simple extrapolation of these data for the female rats
without taking into account the effects of the other
ingredients in the end-use products indicates that non-
domestic products containing greater than 13% carbopheno-
thion would fall in Toxicity Category I and domestic
products containing greater than 1.3% carbophenothion
would fall in Toxicity Category II on the basis of acute
dermal toxicity. These products would be candidates for
restrieted-use.
If the acute toxicity data base for end-use products
were more complete, the Agency would be in a position to
determine which formulations warrant the restricted-use
classification. Unfortunately, this is not the case.
Therefore, the Agency has decided to be conservative and
require that all products be classified as restricted-use
unless appropriate toxicity studies and other information
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is presented to show otherwise.
8. Under FIFRA the Agency cannot cancel or withhold registration
simply because data are missing or inadequate (see Sections
3(c)(2)(B) and 3(c)(7) of the FIFRA). Rather, issuance of
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this Standard provides a mechanism for identifying data needs.
These data will be reviewed and evaluated when they are re-
ceived and the Agency will determine at that time whether
they will affect the registration(s) of carbophenothion.
E. CRITERIA FOR PRODUCTS SUBJECT TO THE GUIDANCE DOCUMENT
This Guidance Document covers products that contain carbo-
phenothion as the sole ingredient and the chart in the Intro-
duction describes the extent to which such products are
subject to this Guidance Document. Applicants for registration
or reregistration of such products must comply with all
terms and conditions described herein. This includes making
a commitment to fill data gaps on a schedule specified by
the Agency. Also, applicants for reregistration must follow
the instructions contained in this Guidance Document and
complete and submit the appropriate forms within the specified
times. End-use products must be in compliance with the
label changes specified in this Document.
F. ACCEPTABLE RANGES AND LIMITS
1. Product Composition Statements
To be covered under this Guidance Document, manufacturing-use
products must contain carbophenothion as the sole active
ingredient. Each MP formulation proposed for registration
or reregistration must be fully described with an appropriate
certification of limits.
2. Acute Toxicity Limits
The Agency will consider for registration any MP whose acute
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toxicity category (I, II, III, IV) is supported by adequate
acute toxicology data and appropriate precautionary statements
in the labeling.
G. REQUIRED LABELING
All manufacturing-use products containing carbophenothion
must bear appropriate labeling as specified in 40 CFR 162.10.
More specific requirements are as follows:
1. Label Requirements for Manufacturing-Use Products
a. Ingredient Statement
The ingredient statement for MPs must list the active
ingredient as:
Carbophenothion, (S-[[(p-chlorophenyl)thio]methyl] O,0-
diethyl phosphorodithioate) % .
b. Use Pattern Statement
All MPs must state that they are intended only for formu-
lation into end-use products for any of the use patterns
listed below. A limiting factor will be the data that support
each use pattern. No use may be included on the label
where the registrant fails to agree to comply with the data
requirements in either TABLE A or TABLE B for that use pattern.
0 Terrestrial, non-domestic, food uses on: alfalfa;
alfalfa (seed crop); almond; apricot; apple; beans,
dried-type (dry shelled beans); beans, dried type (seed
crop); beans, succulent (lima)(seed crop); beans, succulent
' (snap)(seed crop); beets (seed crop); blueberries (lowbush);
cantaloupe; cantaloupe (seed crop); cherry; clover;
clover (seed crop); corn, field; corn, sweet; corn,
field (seed crop); corn, sweet (seed crop); cotton; crab-
apple; cucumber; cucumber (seed crop).; eggplant; eggplant
(seed crop); fig; grapefruit; grape; lemon; lime; nectarine;
olive; onion, dry; onion, green; onion dry (seed crop);
onion, green (seed crop); orange; pear; pepper; pepper
(seed crop); pimento; pimento (seed crop); peach; peas,
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succulent; peas, succulent (seed crop); pecan; plum;
prune; quince; sorghum; sorghum (seed crop); soybean,
edible (seed crop); soybean, edible; spinach; spinach
(seed crop); squash, summer; squash, summer (seed crop);
strawberry; sugar beets; sugar beet (seed crop); tea
(dried); tomato; tomato (seed crop); tangelo; tangerine;
tomato; walnut; watermelon; watermelon (seed crop).
0 Terrestrial, non-domestic, non-food uses on: lawns and
turf (including ground covers); Christmas tree plantings;
forest trees; ornamental plants (herbaceous, woody
shrubs, trees and vines).
0 Terrestrial, domestic, non-food use on: lawns
The attached Index Entry summarizes all currently acceptable
uses for single active ingredient products containing carbopheno-
hion, including sites of application, target pests, dosage
rates, restrictions and limitations, and the method and
frequency of application.
b. Precautionary Statements
Labels for all MP products containing carbophenothion must
bear statements reflecting the hazards to man and the environ-
ment [40 CFR 162.10] .
0 Based on data reviewed by the Agency, the environmental
hazard statement below is required to appear on all MP
products containing carbophenothion:
This pesticide is toxic to freshwater and estuarine fish
and invertebrates. Do not discharge into lakes, streams,
ponds, or public waters unless in accordance with an NPDES
permit. For guidance contact your Regional Office of the EPA.
2. Label Requirements for End-Use Products
a. Ingredient Statement
The ingredient statement for EP's must list the
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active ingredient as:
Carbophenothion, (S-[[(p-chlorophenyl)thio]methyl] O,0-
diethyl phosphorodithioate) %.
b. Precautionary Statements
Labels for all EP's containing carbophenothion must bear
statements reflecting the hazard to man and the environment.
Specific label requirements are listed below:
0 In the absence of crop rotation data, the crop rotation
restriction below must be placed on all EP's which may be
used in a situation where rotation with crops used for
food or feed that are not registered with carbophenothion
may occur:
Do not rotate with any crop used for food or feed which is
not registered for use with carbophenothion.
0 Based on data reviewed by the Agency, the following environmental
hazard statement is required to appear on all EP's:
This pesticide is toxic to freshwater and estuarine fish
and invertebrates. Do not apply directly to water or
wetlands. Drift and runoff from treated areas may be
hazardous to fish and invertebrates in adjacent aquatic
sites. Do not contaminate water by cleaning of equipment
or disposal of wastes. Cover or incorporate spills.
0 To avoid the possible misuse of carbophenothion in green-
houses, which is not a registered site for this chemical,
the phytotoxicity caution currently appearing on registered
labels must be reworded to read:
A few ornamentals, including some crassulaceae, certain
ferns, and a few very sensitive rose varieties, have been
injured. [Delete reference to greenhouse rose varieties]
0 All products must add the restricted use statement:
RESTRICTED USE PESTICIDE
For retail sale to and use only by Certified Applicators or
persons under their direct supervision, and only for those
uses covered by the Certified Applicator's certification.
(Registrants have the option of revising the label to
reflect a restricted-use classification, or submitting
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data. See under TABLE C.)
0 The worker protection statments below must appear on all
products intended for non-domestic use, if they do not
already appear on the labeling:
Wear rubber gloves, protective clothing, rubber overshoes
and goggles.
Wear a respirator jointly approved by the Mining Enforce-
ment and Safety Administration (formerly U.S. Bureau of
Mines) and the National Institute of Occupational Safety
and Health under the provisions of 30 CFR Part II."
0 The worker protection statment below must appear on all
products intended for domestic use:
Wear protective clothing, including gloves and shoes, when
handling or applying.
0 The reentry statements below must appear on all carbophenothion
labels with directions for use on crops:
Do not reenter treated fields within 48 hours unless
protective clothing is worn.
0 All products with domestic outdoor usage on home lawns
arid ornamentals must contain the statement(s) below:
Water material into soil immediately after application. Do not
enter treated areas or allow children and pets on lawn for 24
hours and until grass has completely dried.
Do not contact treated ornamentals for 24 hours following
treatment.
Refer to PR Notice 83-2 for additional information on reentry
and worker protection labeling requirements.
H. TOLERANCE REASSESSMENT
The tolerances for combined residues of carbophenothion and
its cholinesterase-inhibiting metabolites are published in
40 CFR 180.156. A summary of these tolerances is presented
in Table 1.
Tolerances for numerous raw agricultural commodities as well
as processed products are not supported by available data.
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Additional data are required to support the tolerances for
carbophenothion residues in or on the following commodities:
alfalfa (fresh and hay); almond hulls; apples; apricots;
bean straw; cantaloups; cherries; clover (fresh and
hay); corn (sweet); corn forage; cottonseed, crabapples,
dried citrus pulp and meal (21 FR 561.70), eggplant,
figs; garden beet roots and tops; grapefruit; grapes;
lemons; lima beans (succulent); limes; nectarines; olives;
onions (green and dry bulb); oranges; peaches; pears;
pecans; peppers; pimentos; plums (fresh prunes); quince;
snap beans; sorghum forage and grain; spinach; strawberries;
sugar beet roots and tops; summer squash; tangerines; tea
(dried; 21 CFR 193.50); tomatoes; walnuts; and watermelons.
Residue data and tolerance proposals must be submitted for
the following raw agricultural commodities for which tolerances
are not currently established:
alfalfa seed; bean vines; corn grain; corn fodder and
silage; sorghum fodder and silage; eggs; and poultry
(fat, meat, and meat by-products).
No new crop groupings can be established at this time because
of extensive residue chemistry data gaps. Compatibility
between Codex MRL's and U.S. tolerances will be assessed
when data gaps specified in Table A have been submitted and
evaluated.
Changes to 40 CFR 180.156 are indicated as follows:
0 40 CFR 180.156 will be amended to read soybeans per se^
from soybeans (succulent form), since succulent soybeans
are rarely consumed.
0 40 CFR 180.156 will be amended to include a tolerance for
0.1 in the meat of horses.
0 40 CFR 180.156 will be amended to change the tolerance for
milk from zero to 0.01 ppnu
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-------
In order to maintain the use of carbophenothion on feed crops
and peas, The registrant must petition the Agency to establish
the following tolerances:
0 A tolerance for the establishment of 0.1 ppm in or on
dry peas.
0 A tolerance for the establishment of 0.05 ppm in the
meat and meat by-products of cattle, goats, hogs, horses
and sheep.
The Agency's assessment of the tolerance proposals covering
residues -of carbophenothion in animal tissues (except poultry),
is tentative, and is contingent upon the submission of information
concerning the interval between the final dosage and slaughter
in the cattle feeding study reviewed under this Guidance
Document. If the interval was 24 hours or less, then the
above tolerance proposals are valid. If the interval is
greater than 24 hours, then additional data will be required.
Furthermore, the metabolism of carbophenothion in plants and
animals is not adequately understood and constitutes a data
gap. In the event that toxic metabolites other than those
currently known are identified, additional feeding studies
using these metabolites may be required.
The Acceptable Daily Intake (ADI) for carbophenothion is 0.0125
mg/kg/day. This is based on an acceptable dog chronic feeding
study with a No Observed Effect Level (NOEL) of 5.0 ppm
and a safety factor of 10. The Theoretical Maximum Residue
Contribution (TMRC), based on relevant food factors and the
tolerances cited in 21 CFR 193.50 and 40 CFR 180.156, is
0.5806 mg/day assuming a 1.5 kg diet. Accordingly, the
percentage of the ADI used up is 77.42%.
19
-------
TABLE I.
SUMMARY OF PRESENT TOLERANCES
Tolerances (ppm)
Commodity United States3/ Canada Mexico International (Codex)
alfalfa (fresh)
alfalfa (hay)
almond hulls
apples
apricots
beans (dry)
beans, snap *>/
(succulent form)
beans , lima
(succulent form)
bean straw
bean (vines)
beets, garden (roots)
beets, garden (tops)
blueberries
cantaloups
cherries
citrus
clover (fresh)
clover (hay)
corn forage
corn (kernels
plus cob with
husks removed)
undelinted cotton-
seed
crabapples
cucumbers
eggplants
figs
grapefruit6/
grapes
lemons6/
limes6
milk
nectarines
olives
olive oil
onions (green,
dry bulb)
oranges6/
5.0
5.0
10.0
0.8
0.8
0.1
0.8
0.8
5.0
-
0.8
0.8
4.0
0.8
0.8
5.0
5.0
5.0
0.2
0.2
0.8
0.8
0.8
0.8
2.0
0.8
2.0 ,
2.0
-
0.8
.0.8
-
0.8
2.0
5.0 per se
5.0 per se
-
0.8 per se 0.8 per se
-
0.1 per se
(negligible
residue)
0.8 per se
-
5.0 per se
-
-
-
-
0.2 per se
0.5 per se
2.0 per se
-
-
5.0 per se
0.2 per se
0.2 per se
0.8 per se
0.8 per se
0.5 per se 0.8 per se
0.8 per se
-
0.2 per se
-
-
-
_'
- -
- -
0.8 per se 0.8 per se
_ ^
-
-
1 .0
1 .0
-
-
-
-
-
-
-
-
—
2.0
-
-
-
-
—
-
0.004
1 .0
0.1
0.2
20
-------
TABLE I.
SUMMARY OF PRESENT TOLERANCES
Tolerances (ppm)
Commodity
United Statesa/ Canada
Mexico
International (Codex)
peaches
pears
peas (succulent form)
pecans
peppers^/
pimentos
plums (fresh prunes )£'
quinces
sorghum forage
sorghum grain
soybeans (succulent
form)
spinach
strawberries
sugarbeets (roots)
sugarbeets (tops)
summer squash
tangerines^'
tea (dried)
tomatoes
walnuts
watermelons
fat of meat of
cattle, goats,
hogs and sheep
0.8
0.8
orm) 0.8
0.1
0.8
0.8
es)d/ 0.8
0.8
5.0
2.0
nt 0.8
0.8
0.8
) 5.0
5.0
0.8
2.0
20.0
0.8
0.1
0.8
0.8 per se
0.8 per se 0.8 per s_e
0.8 per se
0.1 per se
(negligible
residue)
0.5 per se 0.8 per se
0.5 per se
0 . 5 per se
0.8 per se -
5.0 per se
2.0 per se
0.8 per s_e
0.8 per s_e
0.8 per se
-
-
0.8 per se
-
-
0.5 per se 0.8 per se
0.1 per se
(negligible
residue)
0.8 per se
1.0
1.0
-
0.02
-
1.0
-
-
-
••
2.0
—
0.1
-
-
-
-
-
0.02
-
0.1
1.0
^/Tolerance is based on residues of carbophenothion and its cholinesterase-
inhibiting metabolites.
b/ The Mexican tolerance covers string beans only.
^/ The Mexican tolerance covers chili peppers only.
£/ The Canadian tolerance covers plums and prunes.
£/ A feed additive tolerance of 10 ppm has been established in or on grapefruit,
lemons, limes, oranges and drid citrus pulp and citrus meal.
21
-------
Index of Currently Acceptable Uses**
EPA Index to Pesticide Chemicals
^8102" ' CARBOPHENOTHION*
TYPE PESTICIDE; Insecticide, Acaricide
FORMULATIONS;
Tech (90%);
FI (25%);
D (1.5%, 2%, 3%);
G (0.825%, 3%, 3.15%, 5%, 5.65%, 10%);
P/T (0.54%);
WP (25%);
EC (0.125 Ib/gal, 2 Ib/gal, 4 Ib/gal, 6 Ib/gal, 8 Ib/gal, 2.5%)
GENERAL WARNINGS AND LIMITATIONS; All formulations labeled for non-do-
mestic use that are 25 percent and greater and all formulations labeled
for domestic use that are 10 percent and greater are RESTRICTED USE PES-
TICIDES. Shrimp and crabs may be killed at listed application rates. Do
not apply where these are important resources.
Worker Protection;
Non-domestic uses; Wear rubber gloves, protective clothing, rubber
overshoes, and goggles. Wear a respirator jointly approved by the Min-
ing Enforcement and Safety Administration (formly U.S. Bureau of Mines)
and the National Institute of Occupational Safety and Health under the
provisions of 30 CFR Part II.
Domestic uses: Wear protective clothing including gloves and shoes,
when handling or applying.
Bee Caution;
This product is toxic to bees exposed to direct treatment or residues on
blooming crops or weeds. Do not apply this product if bees are visiting
the application area.
Agricultural Crop Tolerances;
Tea - 20 ppm (dried)
Livestock Tolerances;
Cattle (fat, meat, meat byproduct) - 0.1 ppm
Goats (fat, meat, meat byproduct) - 0.1 ppm
Hogs (fat, meat, meat byproduct) - 0.1 ppm
Milk (fat) - zero ppm
Sheep (fat, meat, meat byproduct) - 0.1 ppm
*Trithion
S-[[(p-Chlorophenyl)thlo]methyl] 0,0-diethyl phosphorodithioate
**covers single active ingredient labeling only
Issued: 5-11-82 III-058102-1
Provisional Update: 5-02-84
-------
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
/23001AA
/23003AA
IRAEAKA
IRACAIA
IKAFAJA
IRACDPA
Site and Pest
AGRICULTURAL CROPS
Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations; Do not reenter treated fields within
48 hours unless protective clothing is worn. Do not rotate with any crop
used for food or feed which is not registered for use with carbopheno-
thion. Per acre rates may be applied by aircraft. Do not apply carbo-
phenothion-oil tank mixes to trees where soil moisture is low, where soil
moisture has recently been low, when temperatures are in excess of 90 F
(32.2 C), or in periods of low humidity caused by dry winds. Do not com-
bine carbophenothion-oil tank mixes with sulfur or apply within 30 days
of a sulfur application. Do not apply to citrus citron or kumquat. Apply
when pest first appears and repeat as needed, unless otherwise specified.
On deciduous and citrus fruit crops, per 100 gallon rates may be applied
as concentrate applications by low volume ground equipment if the same
rate per acre is applied.
In CA observe the following minimum water volume gallonages for per acre
rates, on the following crops:
Vegetable and field crops, apply in a minimum of 5 gallons of water by
aircraft or in a minimum of 20 gallons of water by ground equipment.
Small fruit crops, apply in a minimum of 7 gallons of water by aircraft
or in a minimum of 20 gallons of water by ground equipment.
Deciduous fruit crops, apply in a minimum of 10 gallons of water by air-
craft or in a minimum of 40 gallons of water by ground equipment.
Citrus fruit crops, apply in a minimum of 10 gallons of water by air-
craft or in a minimum of 100 gallons of water by ground equipment.
In areas other than CA observe the following water volume gallonages for
per acre rates, on the following crops:
Vegetable and field crops, apply in a minimum of 1 gallon of water by
aircraft, in 5 to 20 gallons of water by low volume ground equipment,
or in 20 to 250 gallons of water by high volume ground equipment.
Deciduous fruit crops, apply in a minimum of 5 gallons of water by air-
craft, in 20 to 100 gallons of water by low volume ground equipment, or
in 100 to 800 gallons of water by high volume ground equipment.
Citrus fruit crops, apply in a minimum of 10 gallons of water by air-
craft or in 400 to 2000 gallons of water by ground equipment.
Young fruit plantings, apply in a minimum of 15 gallons of water.
Alfalfa
Clover
Meadow spittlebug
Pea aphid
Potato leafhopper
Spotted alfalfa
aphid
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4-8 lb/
gal EC)
5 ppm (fresh forage and hay)
28 day pregrazing or preharvest in-
terval through 1 pound per acre for
foliar application. Do not make
more than 1 application per cutting.
Foliar application. For meadow
spittlebug, apply the higher rate.
Issued: 5-11-82
III-058102-2
-------
EPA Index to Pesticide Chemicals
Site and Pest
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
:LAVBEA
'23001BA
'23003BA
•-LAVAUA
1RACAIA
1RACDPA
:LAVBEA
lOABADA
'03001AA
[RACAAB
[LAAABB
LRAAABA
Alfalfa cluster (continued)
Pest list continued from previous page.
Twospotted spider
mite
Alfalfa (seed crop)
Clover (seed crop)
Brown wheat mite
Pea aphid
Spotted alfalfa
aphid
Twospotted spider
mite
Serpentine leaf-
miner complex
Almond
ERACAAA
ELAAABA-
Aphids (eggs)
Mites (eggs)
Scales (including
European fruit
lecanium, olive
scale, San Jose
scale)
Aphids
Mites
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4-8 lb/
gal EC)
N.F.
Do not graze or feed crop residue
to livestock.
Foliar application to seed crop.
0.25-0.5 lb/
100 gal
[minimum 1
Ib/A]
(25% WP)
(4-6 lb/
gal EC)
or
2 Ib/A
(8 Ib/gal EC)
1.2-1.8 Ib/A
(3% D)
10 ppm (hulls)
7 day preharvest interval through
1.8 pounds per acre of dust formula-
tion or 2.5 pounds per acre of spray
formulations for foliar application
if hulls are to be harvested for
feed.
Do not make more than 1 application
during the fruiting period. Multi-
ple applications may be made if
hulls are not to be harvested for
feed. Do not allow livestock to
graze treated areas.
Dormant or postharvest application.
Tank mix with petroleum distillate.
Foliar application.
Issued: 5-11-82
III-058102-3
-------
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
•-RACAAA
1RAFAAA
iLAVAAA
:LAVACA
IIAVASA
:LAVBEA
Site and Pest
Almond (continued)
Aphlds
Leafhoppers
Spider mites
Brown mite
European red mite
Twospotted spider
mite
Dosages and Tolerance, Use, Limitations
Formulation(s)
[LAAABA
CTAMABA
Mites
Peach twig borer
Postharvest application to reduce
overwintering populations.
0.25-0.5 lb/
100 gal
(25% WP)
(4-8 lb/
gal EC)
1.05-1.5 Ib/A Foliar application.
(3% D)
or
0.25 lb/
100 gal
[minimum 1
Ib/A]
(25% WP)
or
1-2 lb/50
gal/A
(4 Ib/gal EC)
0.5-1 lb/ Foliar application.
20 gal/A craft.
(4 Ib/gal EC)
Apply by air-
0.25 lb/100 Foliar application. In CA, may be
gal tank mixed with petroleum distil-
(4 Ib/gal EC) late.
or
2-2.5 Ib/A
(8 Ib/gal EC)
0.5 lb/100 Use limited to CA.
gal
(4-8 lb/
gal EC)
or
0.5 Ib/A
(8 Ib/gal EC)
Delayed dormant and foliar applica-
tion. Apply prebloom and at petal
fall.
Issued: 5-11-82
III-058102-4
-------
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
04001AA
0*4002AA
04003AA
04004AA
RACAAB
LAAABB
RAXALA
RAAABA
RACAAA
RAFAAA
LAVAAA
RACAUA
TBGAZA
RAFAAA
RACBQA
LAVAAA
RACBUA
RACAAB
LAVASA
RAKBYA
Site and Pest
Apple
Crabapple
Pear
Quince
Aphids (eggs)
Mites (eggs)
Pear psylla
Scales (including
forbes scale,
oystershell
scale, putnam
scale, San
Jose scale,
scurfy scale)
Aphids
Leafhoppers
Spider mites
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.8 ppm
30 day preharvest interval through
1.25 pounds per acre for foliar ap-
plication. Do not apply to Cortland
variety of apple.
Apple aphid
Codling moth
Leafhoppers
Rosy apple aphid
Spider mites (in-
cluding brown
mite, European red
mite, twospotted
spider mite)
Woolly apple aphid
(Apple)
Aphids (eggs)
European red mite
San Jose scale
0.25-0.5 lb/
100 gal
[minimum 1
Ib/A]
(25% WP)
(4-8 lb/
gal EC)
or
1.25 Ib/A
(8 Ib/gal EC)
0.25-0.5 lb/
100 gal
[minimum 1
Ib/A]
(25% WP)
(4-8 lb/
gal EC)
0.8-1.2 Ib/A
(2-3% D)
Dormant, delayed dormant, or post-
harvest application. Tank mix with
petroleum distillate.
Postharvest application to reduce
overwintering populations.
0.25-0.375 lb
/100 gal
(25% WP)
or
0.25 lb/
100 gal
[minimum 1
Ib/A]
(4-8 lb/
gal EC)
Delayed dormant and foliar applica-
tion. Apply at prepink stage and
repeat as needed.
Foliar application. Apply only af-
ter full leaf expansion. Do not re-
peat at less than 10 day intervals
as injury may result. For codling
moth, apply at petal fall and repeat
at 10 to 14 day intervals until con-
trol is achieved.
0.25 lb/100
gal
(0.125 lb/
gal EC)
0.375 lb/100
gal
(0.125 lb/
gal EC)
Delayed dormant application.
Issued: 5-11-82
Ill-058102-5
-------
EPA Index to Pesticide Chemicals
05001AA
RACAAB
LAAABB
RAAABA
RACAAA
.LAAABA
RACAAA
.RAFAAA
.LAUAAA
.TBGAZA
:RACBAA
:RAFAAA
:RACCAA
•-LAVAAA
Site and Pest
Apricot
Aphids (eggs)
Mites (eggs)
Scales (including
brown soft scale,
European fruit
lecanium, San
Jose scale)
Aphids
Mites
Aphids
Leafhoppers
Spider mites
Codling moth
Leafcurl plum
aphid
Leafhoppers
Mealy plum aphid
Spider mites (in-
cluding brown
mite, European
red mite, two-
spotted spider
mites)
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.8 ppm
30 day preharvest interval through
1.8 pounds per acre of dust formula-
tions or 2 pounds per acre of spray
formulations for foliar application.
Do not allow livestock to graze
treated areas.
0.25-0.5 lb/
100 gal
[minimum 1
lb/A]
(25% WP)
(4-8 lb/
gal EC)
or
2 lb/A
(8 Ib/gal EC)
0.8-1.8 lb/A
(2-3% D)
0.25-0.5 lb/
100 gal
[minimum 1
lb/A]
(25% WP)
(4-8 lb/
gal EC)
0.25 lb/100
gal
[minimum 1
lb/A]
(25% WP)
(4-8 lb/
gal EC)
or
1.5-2 lb/A
(8 Ib/gal EC)
Dormant or postharvest application.
Tank mix with petroleum distillate.
Foliar application.
Postharvest application to reduce
overwintering populations.
Foliar application. For codling
moth, apply at petal fall and repeat
at 10 to 14 day intervals until con-
trol is achieved.
Issued: 5-11-82
I11-058102-6
-------
EPA Index to Pesticide Chemicals
15001AA
.RACAMA
.NAPAFA
.RAFAJA
.OABADA
.LAVBEA
Site and Pest
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
Beans, Dried-type (dry shelled
beans)
Bean aphid
Mexican bean
beetle
Potato leafhopper
Serpentine leaf-
miner complex
Twospotted spider
mite
0.6 Ib/A
(2-3% D)
or
0.5-0.75 Ib/A
(25% WP)
(4-8 lb/
gal EC)
0.1 ppm (beans)
5 ppm (bean straw)
21 day precutting (for forage), pre-
grazing, or preharvest interval
through 0.5 pound per acre of spray
formulations or 0.6 pound per acre
of dust formulations for foliar
application.
Do not graze or feed treated forage
to livestock if dosages above 0.5
pounds per acre of spray formula-
tions or 0.6 pounds per acre of dust
formulations are used.
Do not make more than 2 applications
during the growing season.
Foliar application.
15001BA
'15002BA
15003BA
28002BA
1501 DBA
'13024BA
10013BA
.RACAMA
:OABADA
:LAVBEA
.RACAIA
Beans, Dried-type (seed crop)
Beans, Succulent (Lima)(seed crop)
Beans, Succulent (Snap)(seed crop)
Beets (seed crop)
Soybeans, Edible (seed crop)
Spinach (seed crop)
Squash (Summer)(seed crop)
N.F.
Do not graze or feed crop residue
to livestock.
Bean aphid
Serpentine leaf-
miner complex
Twospotted spider
mite
Pea aphid
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4-8 lb/
gal EC)
Foliar application to seed crop.
Issued: 5-11-62
III-05 810 2-7
-------
Site and Pest
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
15002AA
15003AA
Beans, Succulent (Lima)
Beans, Succulent (Snap)
RACAMA
NAPAFA
RAFAJA
OABADA
LAVBEA
28002AA
Bean aphid 0.6-1.2 Ib/A
Mexican bean beetle (2-3% D)
Potato leafhopper
Serpentine leaf-
miner complex
Two spotted spider
mite
Beets
0.8 ppm (beans)
5 ppm (bean straw)
7 day preharvest interval through
0.75 pound per acre of spray formu-
lations or 1.2 pounds per acre of
dust formulations for foliar appli-
cation.
21 day precutting (for hay) or pre-
grazing interval through 0.5 pound
per acre of spray formulations or
0.6 pound per acre of dust formula-
tions for foliar application.
Do not graze or feed treated forage
to livestock if dosages above 0.5
pound per acre of spray formulations
or 0.6 pound per acre of dust for-
mulations are applied.
Do not make more than 2 applications
during the growing season for snap
beans.
Foliar application.
or
0.5-0.75 Ib/A
(25% WP)
(4-8 lb/
gal EC)
0.8 ppm (roots and tops)
No preharvest interval through 0.5
pound per acre of spray formulations
or 1.2 pounds per acre of dust for-
mulations for foliar application.
21 day preharvest interval through
0.5 pound per acre of spray formula-
tions or 1.2 pounds per acre of dust
formulations for foliar application
if tops are to be used for food or
feed.
RACAMA
NAMBSA
.OABADA
LAVBEA
Bean aphid
Potato flea beetle
Serpentine leaf-
miner complex
Twospotted spider
mite
0.4-1.2 Ib/A Foliar application.
(2-3% D)
or
0.25-0.5 Ib/A
(25% WP)
(4-8 lb/
gal EC)
Issued: 5-11-82
III-058102-8
-------
Site and Pest
'01009 A A
Beets (seed crop)
Blueberry (Lowbush)
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
See Beans, Dried-type (seed crop) cluster.
4 ppm
14 day preharvest interval through
0.6 pound per acre for foliar appli-
cation.
Do not make more than 2 applications
during the growing season.
COBMAPA
/10002AA
/10008AA
Blueberry maggot
Cantaloupe
Watermelons
[RACAOA
LNAMBSA
tOABADA
LLAVBEA
/10002BA
/10008BA
Melon aphid
Potato flea beetle
Serpentine leaf-
miner complex
Twospotted spider
mite
0.6 Ib/A
(3% D)
0.6-1.2 Ib/A
(2-3% D)
or
0.5-1 Ib/A
(25% WP)
(4-8 lb/
gal EC)
Cantaloupe (seed crop)
Watermelons (seed crop)
Use limited to ME.
Foliar application. Apply by ground
equipment and repeat in 10 to 14
days if needed.
0.8 ppm
5 day preharvest interval through 1
pound per acre of spray formulations
or 1.2 pounds per acre of dust form-
ulations for foliar applications.
Foliar application.
N.F.
Do not graze or feed crop residue
to livestock.
IRAVAUA
IOABADA
ILAVBEA
Brown wheat mite
Serpentine leaf-
miner complex
Two spotted spider
mite
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4-8 lb/
gal EC)
Foliar application to seed crop.
Issued: 5-11-82
III-058102-9
-------
EPA Index to Pesticide Chemicals
05002AA
RACAAB
LAAABB
RAAABA
RACAAA
LAAABA
RACAAA
RAFAAA
LAVAAA
LAJBEA
TBGAZA
RACBAA
.RAFAAA
RACCAA
LAVAAA
Site and Pest
Cherry
Aphids (eggs)
Mites (eggs)
Scales (including
European fruit
lecanium, forbes
scale, olive
scale, San Jose
scale)
Aphids
Mites
Aphids
Leafhoppers
Spider mites
Cherry rust mites
Codling moth
Leafcurl plum
aphid
Leafhoppers
Mealy plum aphid
Spider mites (in-
cluding brown
mite, European
red mite, two-
spotted spider
mite)
Clover
Clover (seed crop)
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Fonnulation(s)
0.8 ppm
30 day preharvest interval through
1.8 pounds per acre of dust formula-
tions or 2 pounds per acre of spray
formulations for foliar application.
Do not allow livestock to graze
treated areas.
Dormant or postharvest application.
Tank mix with petroleum distillate.
Foliar application.
Postharvest application to reduce
overwintering populations.
0.25-0.5 lb/
100 gal
[minimum 1
lb/A]
(25% WP)
(4-8 lb/
gal EC)
or
2 lb/A
(8 Ib/gal EC)
0.8-1.8 lb/A
(2-3% D)
0.25-0.5 lb/
100 gal
[minimum 1
lb/A]
(25% WP)
(4-8 lb/
gal EC)
0.25 lb/100
gal
[minimum 1
lb/A]
(25% WP)
(4-8 lb/
gal EC)
or
1.5-2 lb/A
(8 Ib/gal EC)
See Alfalfa cluster.
See Alfalfa (seed crop) cluster.
Foliar application. For codling
moth, apply at petal fall and repeat
at 10 to 14 day intervals until con-
trol is achieved.
Issued: 5-11-82
111-058102-10
-------
28006AA
r5005AA
LBDABA
LAVBAA
LAVBEA
28006BA
15005BA
RACAMA
LAVBEA
28007AA
LAVAWA
TBCAOA
LAVAZA
LAVBEA
RACAOA
.TAYAHA
Site and Pest
Corn, Field
Corn, Sweet
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.2 ppm (kernels plus cob with
husks removed)
5 ppm (forage)
21 day precutting (for forage) or
pregrazing interval through 1 pound
per acre for foliar application.
Do not make more than 1 application
during the growing season.
Grass mite i ib/A
Pacific spider mite (2-3% D)
Twospotted spider (25% WP)
mite (4-8 lb/
gal EC)
Corn, Field (seed crop)
Corn, Sweet (seed crop)
Bean aphid
Twospotted spider
mite
Cotton
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4-8 lb/
gal EC)
Carmine spider
mite
Cotton leafworm
Tropical spider
mite
Twospotted spider
mite
Cotton aphid
Cotton leaf-
perforator
0.3-1 Ib/A
(2-3% D)
or
0.25-1 Ib/A
(25% WP)
(4-8 lb/
gal EC)
1 Ib/A
(2-3% D)
(25% WP)
(4-8 lb/
gal EC)
Foliar application.
N.F.
Do not graze or feed crop residue
to livestock.
Foliar application to seed crop.
0.2 ppm (undelinted cottonseed)
No preharvest interval through 1
pound per acre for foliar applica-
tion.
Do not apply after bolls have
opened.
Do not allow livestock to graze
treated areas or feed treated plants
to livestock.
Foliar application.
Issued: 5-11-82
III-058102-11
-------
EPA Index to Pesticide Chemicals
QAMAYA
10010AA
10013AA
RACAOA
.RAFAJA
OABADA
LAVBEA
10010BA
11001BA
28017BA
11004BA
11005BA
.OABADA
.LAVBEA
'1001AA
28017AA
11004AA
.NAMBSA
•.RAFAJA
:OABADA
:LAVAZA
.LAVBEA
Site and Pest
Cotton (continued)
Cotton fleahopper
Crabapple
Cucumber
Squash (summer)
Melon aphid
Potato leafhopper
Serpentine leaf-
miner complex
Twospotted spider
mite
Cucumber (seed crop)
Eggplant (seed crop)
Peppers (seed crop)
Pimento (seed crop)
Tomato (seed crop)
Serpentine leaf-
miner complex
Two spotted spider
mite
Eggplant
Peppers
Pimento
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4-8 lb/
gal EC)
See Apple cluster.
0.8 ppm
7 day preharvest interval through 1
pound per acre for foliar applica-
tion.
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4-8 lb/
gal EC)
Foliar application.
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4-8 lb/
gal EC)
N.F.
Do not graze or feed crop residue
to livestock.
Foliar application to seed crop.
0.8 ppm
7 day preharvest interval through 1
pound per acre of spray formulations
or 1.2 pounds per acre of dust form-
ulations for foliar application.
Potato flea beetle 0.5-1.2 Ib/A . Foliar application.
Potato leafhopper (2-3% D)
Serpentine leaf- or .
miner complex 0.5-1 Ib/A
Tropical spider (25% WP)
mite . (4-8 lb/
Twospotted spider gal EC)
mite
Eggplant (seed crop) See Cucumber (seed crop) cluster.
Issued: 5-11-82
III-058102-12
-------
EPA Index to Pesticide Chemicals
Site and Pest
06005AA
LAVBEA
Twospotted spider
mite
02002AA
02004AA
02005AA
02006AA
02007AA
'02008AA
Grapefruit
Lemon
Orange
Tangelo
Tangerine
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.8 ppm
7 day preharvest interval through
2.5 pounds per acre for foliar ap-
plication.
Foliar application.
Issued: 5-11-82
0.8-2.4 Ib/A
(2-3% D)
or
0.25-0.5 lb/
100 gal
[minimum 1
Ib/A]
(25% WP)
(4-8 lb/
gal EC)
or
2-2.5 Ib/A
(8 Ib/gal EC)
2 ppm (citrus fruits)
10 ppm (dehydrated pulp and meal for
cattle feed)
No preharvest interval through 2.5
pounds per acre for foliar applica-
tion.
14 day preharvest interval from
above 2.5 through 3.75 pounds per
acre for foliar application.
30 day preharvest interval through
5 pounds per acre of spray formula-
tions tank mixed with petroleum dis-
tillate for foliar application.
Do no apply at less than 30 day
intervals.
May injure grapefruit in FL if tank
mixed with petroleum distillate in
the summer or if applied alone in
the fall before fruit is fully
colored.
May cause off-colored spots on
grapefruit in TX if applied after
July 1 and before fruit is.fully
colored, or in the summer or ,fall
in other areas before fruit is fully
colored. When applied by aircraft,
craft should fly over the top of
each row to ensure thorough cover-
age. When applied by ground equip-
Use paragraph continued on the next page.
Ill-058102-13
-------
Site and Pest
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
Grapefruit cluster (continued)
RAHAGA
UKAEA
RAHAHA
RARACA
RAKAQA
RAKBDA
RAKAFA
LAVARA
LAJBCA
LAVAHA
LAVAKA
LAVAJA
Brown soft scale
California red
scale
Citricola scale
Co ttonycushion
scale
Florida red scale
Purple scale
Yellow scale
Citrus red mite
Citrus rust mite
Sixspotted mite
Texas citrus mite
Yuma spider mite
RAKCCA
Snow scales
ment, apply to both sides of trees
to ensure thorough coverage.
Do not apply to citrus citron or
kumquat.
Foliar application. Tank mix with
petroleum distillate.
Foliar application.
0.5-0.75 lb/
100 gal
[minimum 1
Ib/A]
(25% WP)
(4-8 lb/
gal EC)
or
3.25 Ib/A
(8 Ib/gal EC)
1-3 Ib/A
(2-3% D)
or
0.25-0.5 lb/
100 gal
[minimum 1
Ib/A]
(25% WP)
(4-8 lb/
gal EC)
or
2-3.25 Ib/A
(8 Ib/gal EC)
0.375 lb/ Use limited to FL.
100 gal Foliar application.
(4 Ib/gal EC) May be tank mixed with petroleum
distillate.
Issued: 5-11-62
III-058102-14
-------
EPA Index to Pesticide Chemicals
01014AA
Site and Pest
Grapes
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.8 ppm
30 day preharvest interval through
0.5 pound per acre of spray formula-
tions or 1 pound per acre of dust
formulations for foliar application.
Do not apply to Charbono, Camay,
Golden Muscat, Muscat, and Italia
varieties.
:RAFAOA
:LAVBEA
Grape leafhopper
Twospotted spider
mite
'05003AA
'05004AA
Peach
:RACAAB
•-RAAABA
Aphids (eggs)
Scales (including
European fruit
lecanium, olive
scale, San Jose
scale)
CRACAAA
[LAAABA
Aphids
Mites
0.6-1 Ib/A
(2-3% D)
or
0.5 Ib/A
(25% WP)
(4-8 lb/
gal EC)
See Grapefruit cluster.
See Grapefruit cluster.
Foliar application.
0.25-0.5 lb/
100 gal
[minimum 1
Ib/A]
(25% WP)
(4-8 lb/
gal EC)
or
1 Ib/A
(8 Ib/gal EC)
0.8-1.8 Ib/A
(2-3% D)
0.8 ppm
30 day preharvest interval through
1.8 pounds per acre of dust formula-
tions or 2 pounds per acre of spray
formulations for foliar application.
Do not allow livestock to graze
treated areas.
Dormant or postharvest application.
Tank mix with petroleum distillate.
Foliar application.
Issued: 5-11-82
III-058102-15
-------
Site and Pest
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
Nectarine cluster (continued)
.RACAAA
.RAFAAA
LAVAAA
Aphids
Leafhoppers
Spider mites
TBGAZA
.RACBAA
.RAFAAA
:RACCAA
.LAVAAA
.LAAABB
.LAAABA
:TAMABA
Mites
Peach twig borer
Postharvest application to reduce
overwintering populations.
Codling moth
Leafcurl plum
aphid
Leafhoppers
Mealy plum aphid
Spider mites (in-
cluding brown
mite, European red
mite, twospotted
spider mite)
Mites (eggs)
Foliar application. Apply per acre
rate in 20 gallons of water per acre
by aircraft. For codling moth, ap-
ply at petal fall and repeat at 10
to 14 day intervals until control
is achieved.
0.25-0.5 lb/
100 gal
[minimum 1
lb/A]
(25% WP)
(4-8 lb/
gal EC)
0.25-0.5 lb/
100 gal
[minimum 1
lb/A]
(25% WP)
(4-8 lb/
gal EC)
or
1 lb/A
(4 Ib/gal EC)
0.5 lb/100
gal
(25% WP)
(4-8 lb/
gal EC)
or
1 lb/A
(8 Ib/gal EC)
0.25-0.5 lb/ Postharvest application.
100 gal Tank mix with petroleum distillate.
[minimum 1
lb/A]
(25% WP)
(4 Ib/gal EC)
0.5 lb/100 Use iimited to CA.
gal Delayed dormant and foliar applica-
(4 Ib/gal EC) tibn. Apply prebloom and at petal
or fall.
0.5 lb/A
(8 Ib/gal EC)
Use limited to CA.
Dormant application. Tank mix with
petroleum distillate.
Issued: 5-11-82
III-058102-16
-------
28014AA
Site and Pest
Olive
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.8 ppm
60 day preharvest interval through
9 pounds per acre for foliar appli-
cation.
.RAHBBA
.RAKBPA
RAKAKA
.RAKBYA
Black scale
Oleander scale
Olive scale
San Jose scale
'14011AA
'16004AA
:OACACA
Onion, Dry
Onion, Green
Onion maggot
Foliar application. Tank mix with
petroleum distillate.
0.5 lb/100
gal
[minimum 1
Ib/A
(25% WP)
or
0.25-0.5 lb/
100 gal
[minimum 1
Ib/A]
(4 Ib/gal EC)
or
6-9 Ib/A
(8 Ib/gal EC)
0.8 ppm
Soil application (at planting)
through 2 pounds per acre.
1-1.5 Ib/A Furrow treatment at seeding or
or transplanting. Apply lower range
1.5-2 Ib/A for mineral soils and higher range
(with 18 for muck or peat soils. Apply dry
inch row formulations using a combination
spacing) drill, fertilizer spreader, or suit-
(2-3% D) able granular application equipment.
(5-10% G) For spray formulations, apply per
(25% WP) acre rates in 100 gallons of water
(4-8 lb/ and apply 3 gallons of finished
gal EC) spray per 1,000 feet of furrow.
Keep mixture agitated.
0.375 lb/25 Seed treatment by slurry for the
lb seed protection of germinating seeds and
(25% WP) seedlings. Thoroughly coat seed in
a slurry.
Issued: 5-11-82
III-058102-17
-------
Site and Pest
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
Onion, Dry cluster (continued)
1 lb/15-25
Ib seed
(25% WP)
Seed treatment (dry) for the protec-
tion of germinating seeds and seed-
lings. Thoroughly coat seed with
methyl cellulose, then tumble the
seed in a seed treater or barrel
treater until seed is thoroughly
coated. Apply higher rate for muck
soil and lower rate for upland
soils.
'14011BA
16004BA
28019BA
:LAVAUA
:LAVBEA
Onion, Dry (seed crop)
Onion, Green (seed crop)
Sorghum (seed crop)
Brown wheat mite
Twospotted spider
mite
'15009AA
CRACAIA
LOABADA
CLAVBEA
Pea aphid
Serpentine leaf-
miner complex
Twospotted spider
mite
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4-8 Ib/
gal EC)
See Grapefruit cluster.
See Nectarine cluster.
See Apple cluster.
N.F.
Do not graze or feed crop residue
to livestock. For sorghum, do not
make more than 1 application per
growing season.
Foliar application to seed crop.
0.6-1.2 Ib/A
(2-3% D)
or
0.5-0.75 Ib/A
(25% WP)
(4-8 Ib/
gal EC)
0.8 ppm
7 day preharvest interval through
0.75 pound per acre of spray form-
ulations or 1.2 pounds per acre of
dust formulations for foliar appli-
cation.
Do not graze or feed crop residue
to livestock.
Foliar application.
Issued: 5-11-82
III-058102-18
-------
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
'Site and Pest
15009BA
.RACAMA
.RACAIA
:OABADA
.LAVBEA
Dosages and Tolerance, Use, Limitations
Formulation(s)
Peas, Succulent (seed crop)
Bean aphid
Pea aphid
Serpentine leaf-
miner complex
Twospotted spider
mite
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4-8 lb/
gal EC)
N.F.
Do not graze or feed crop residue
to livestock.
Foliar application to seed crop.
03008AA
Pecan
0.1 ppm
Do not apply after husk split
through 2.5 pounds per acre for fo-
liar application.
Do not allow livestock to graze
treated areas.
.RACAAA
.LAAABA
:SACAAB
.LAAABB
•-RAAABA
: RACAAA
-RAFAAA
iLAVAAA
iLAVBEA
Aphids
Mites
Aphids (eggs)
Mites (eggs)
Scales (including
European fruit
lecanium, San Jose
scale)
Aphids
Leafhoppers
Spider mites
0.8-1.8 Ib/A
(2-3% D)
0.25-0.5 lb/
100 gal
(25% WP)
(4-6 lb/
gal EC)
Twospotted spider
mite
Foliar application.
Postharvest application. Tank mix
with petroleum distillate.
0.25-0.5 lb/
100 gal
[minimum 1
Ib/A]
(25% WP)
(4 Ib/gal EC)
Postharvest application to reduce
overwintering populations.
0.25 lb/100 Foliar application.
gal
[minimum 1
Ib/A]
(25% WP)
(4 Ib/gal EC)
or
2-2.5 Ib/A
(8 Ib/gal EC)
Issued: 5-11-82
III-058102-19
-------
Site and Pest
Peppers
Peppers (seed crop)
Pimento
Pimento (seed crop)
05005AA
05006AA
RACAAB
LAAABB
RAAABA
.RACAAA
:LAAABA
.TAMABA
.RACAAA
.LAAABA
: RACAAA
:RAFAAA
:LAVAAA
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
See Eggplant cluster.
See Cucumber (seed crop) cluster.
See Eggplant cluster.
See Cucumber (seed crop) cluster.
0.8 ppm
30 day preharvest interval through
1.8 pounds per acre of dust formula-
tions or 2 pounds per acre of spray
formulations for foliar application.
Do not allow livestock to graze
treated areas.
Aphids (eggs)
Mites (eggs)
Scales (including
European fruit
lecanium, olive
scale, San Jose
scale)
Aphids
Mites
Peach twig borer
Aphids
Mites
Aphids
Leafhoppers
Spider mites
0.25-0.5 lb/
100 gal
[minimum 1
lb/A]
(25% WP)
(4-8 lb/
gal EC)
or
2 lb/A
(8 Ib/gal EC)
0.5 lb/100
gal
Dormant or postharvest application.
Tank mix with petroleum distillate.
Use limited to CA.
Delayed dormant and foliar applica-
(4 Ib/gal EC) tion. Apply prebloom and at petal
or fall.
1.5-2 lb/A
(8 Ib/gal EC)
0.8-1.8 lb/A
(2-3% D)
0.25-0.5 lb/
100 gal
[minimum 1
Ib/AJ
(25% WP)
(4-8 lb/
gal EC)
Foliar application.
Postharvest application to reduce
overwintering populations.
Issued: 5-11-82
III-058102-20
-------
TBGAZA
RACBAA
.BAFAAA
RACCAA
LAVAAA
28019AA
:RACDNA
1LAVBNA
1RACAIA
10AHAIA
CLAVBEA
Site and Pest
EPA Index to Pesticide Chemicals
GARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
Plum cluster (continued)
Codling moth
Leafcurl plum
aphid
Leafhoppers
Mealy plum aphid
Spider mites (in-
cluding brown
mite, European red
mite, twospotted
spider mite)
Quince
Sorghum
0.25-0.5 lb/
100 gal
[minimum 1
lb/A]
(25% WP)
(4-8 lb/
gal EC)
or
1-2 lb/A
(8 Ib/gal EC)
See Apple cluster.
Foliar application. For codling
moth, apply at petal fall and repeat
at 10 to 14 day intervals until con-
trol is achieved.
Greenbug
2 ppm (grain)
5 ppm (forage)
21 day precutting (for forage) or
pregrazing interval through 1 pound
per acre for foliar application. Do
not make more than 2 applications
during the growing season for dos-
ages through 0.5 pound per acre.
Do not make more than 1 application
per growing season for dosages from
above 0.5 through 1 pound per acre.
Under certain climatic conditions,
may cause a slight discoloration to
foliage of some varieties.
Use limited to TX.
Foliar application.
Oligonychus mites
Pea aphid
Sorghum midge
Iwospotted spider
mite
Foliar application.
0.5-1 lb/A
(4-8 lb/
gal EC)
0.5-1 lb/A
(4-8 lb/
gal EC)
1 lb/A
(2-3% D)
(25% WP)
or
0.5-1 lb/A
(4-8 lb/
gal EC)
Sorghum (seed crop) See Onion, Dry (seed crop) cluster.
Issued: 5-11-82
111-058102-21
-------
L5010AA
Site and Pest
Soybeans, Edible
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.8 ppm
7 day preharvest interval through
0.75 pound per acre of -spray form-
ulations or 1.2 pounds per acre of
dust formulations for foliar appli-
cation.
Do not graze or feed crop residue
to livestock.
Refer to Beans, Succulent (snap).
Soybeans, Edible (seed crop)
See Beans, Dried-type (seed crop) cluster.
13024AA
Spinach
RACAMA
OABADA
LAVBEA
01016AA
Bean aphid
Serpentine leaf-
miner complex
Twospotted spider
mite
Spinach (seed crop)
Squash
Squash (seed crop)
Strawberry
RACBGA
LAVBEA
Strawberry aphid
Twospotted spider
mite
0.8 ppm
21 day preharvest interval through
0.5 pound per acre of spray form-
ulations or 1.2 pounds per acre of
dust formulations for foliar appli-
cation.
0.4-1.2 Ib/A Foliar application.
(2-3% D)
or
0.25-0.5 Ib/A
(25% WP)
(4-8 lb/
gal EC)
See Beans, Dried-type (seed crop) cluster.
See Cucumber cluster.
See Beans, Dried-type (seed crop) cluster.
0.8 ppm
3 day preharvest interval through
0.5 pound per acre of spray formula-
tion or 1.2 pounds per acre of dust
formulation for foliar application.
0.5-1.2 Ib/A Foliar application.
(2-3% D)
or
0.5 Ib/A
(25% WP)
(4-8 lb/
gal EC)
Issued: 5-11-82
III-05 810 2-2 2
-------
'2802QAA
1RACAMA
1NHMBSA
lOABADA
:LAVBEA
CQAXACA
'28020BA
[RACAMA
LOABADA
LLAVBEA
Site and Pest
Sugar Beets
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
5 ppm (roots and tops)
14 day preharvest interval through
1 pound per acre for foliar appli-
cation.
Soil application (at seeding)
through 1 pound per acre.
Tops may be harvested for feed.
Bean aphid
Potato flea beetle
Serpentine leaf-
miner complex
Twospotted spider
mite
(Sugarbeet root
maggot)
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4-8 lb/
gal EC)
1 Ib/A
(10% G)
Sugar Beets (seed crop)
Bean aphid
Serpentine leaf-
miner complex
Twospotted spider
mite
Tangelo
Tangerine
Foliar application.
0.5-1 Ib/A
(2-3% D)
(25% WP)
(4 Ib/gal EC)
See Grapefruit cluster.
See Grapefruit cluster.
Soil application at seeding.
Apply in the drill row just above
the seed using a combination drill
or suitable granular applicable
equipment.
N.F. (seed crop)
5 ppm (tops)
14 day preharvest interval through
0.9 pound per acre if crop residue
is to be fed to livestock.
Foliar application to seed crop.
Issued: 5-11-82
III-058102-23
-------
L1005AA
4AMBSA
.UFAJA
DABADA
RAXAHA
LAJAHA
LAVAZA
LAVBEA
03009AA
RACAAA
LAAABA
RAHAKA
RAHALA
RAHAPA
LAAABB
RACBHA
TBGAZA
RAHALA
LAVASA
LAVBEA
RACBHA
Site and Pest
Tomato
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.8 ppm
7 day preharvest interval through 1
pound per acre of spray formulations
or 1.2 pounds per acre of dust for-
mulations.
Potato flea beetle
Potato leafhopper
Serpentine leaf-
miner complex
Tomato psyllid
Tomato russet mite
Tropical spider
mite
Two spotted spider
mite
Tomato (seed crop)
Walnut
Aphids
Mites
Calico scale
European fruit
lecanium
Frosted scale
Mites (eggs)
Walnut aphid
Codling moth
(European fruit
lecanium)
European red mite
Two spotted spider
mite
Walnut aphid
0.5-1.2 Ib/A
(2-3% D)
or
0.5-1 Ib/A
(25% WP)
(4-8 lb/
gal EC)
Foliar application.
See Cucumber (seed crop) cluster.
0.8-1.8 Ib/A
(2-3% D)
1-2 Ib/A
(25% WP)
(4-6 lb/
gal EC)
1-2 Ib/A
(25% WP)
(4-8 lb/
gal EC)
0.1 ppm
Do not apply after husk split
through 2 pounds per acre for foliar
application.
Do not allow livestock to graze
treated areas.
Foliar application.
Dormant application.
Tank mix with petroleum distillate.
Foliar application. For codling
moth, apply at petal fall and repeat
at 10 to 14 day intervals until con-
trol is a-chieved. For scale sup-
pression, apply after eggs have
hatched.
Issued: 5-11-82
111-058102-24
-------
!OBMAMA
Site and Pest
Walnut (continued)
Walnut husk fly
Watermelons
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
1 lb/100 gal Use limited to CA.
(25% WP) Foliar application. Apply at first
sign of population increase after
fly emergence in July. Tank mix
with bait.
1.5 Ib/A Foliar application.
[minimum 200
gal/A]
(25% WP)
See Cantaloupe cluster.
Watermelons (seed crop)
See Cantaloupe (seed crop) cluster.
'31012AA
'31018AA
'35021AA
'31025AA
'34022AA
'35027AA
'31038AA
'35030AA
'34031AA
'31046AA
'34036AA
'31057AA
'35037AA
'31062AA
'31065AA
'31066AA
'35095AA
'31071AA
'31077AA
'34045AA
'34047AA
/31084AA
'31129AA
ORNAMENTALS
General Warnings and Limitations; Do not contact treated ornamentals for
24 hours following treatment. Apply when pest first appears and repeat
as needed, unless otherwise specified.
(Ornamental Plants (herbaceous, woody shrubs, trees and vines))
African Violets
Amaryllis
Arborvitae
Asparagus Fern
Azalea
Beech
Bird-Of-Paradise
Black Locust
Boxwood
Cacti
Camellia
Carnation
Cedar
China Aster
Chrysanthemum
Cineraria
Citrus (Ornamental)
Coleus
Cosmos
Cotoneaster
Crotons
Dahlias
Delphinium
Certain ornamentals including some
Crassulaceae, certain ferns, and a
few very sensitive rose varieties
have been injured. When sensitivity
is questionable, carbophenothion
should be tested on a few plants.
Use with caution on tender plants.
Otherwise, tolerance of most plants
to carbophenothion appears to be
excellent.
Issued: 5-11-82
111-058102-25
-------
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Site and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
African Violets cluster (continued)
/35049AA Elm
/35050AA Eucalyptus
/34053AA Euonymous
/31098AA Euphorbia
/31215AA Fibrous Begonia
/35051AA Fir
/35052AA Flowering Almond
/35055AA Flowering Cherry
/34060AA Flowering Currant
/35058AA Flowering Peach
/35060AA Flowering Plum
/31104AA Fuchsia
/34063AA Gardenia
/35096AA Guava (Ornamental)
/34066AA Hawthorn
/34068AA Heather
/35068AA Hemlock
/34070AA Holly
/31121AA Hollyhock
/34073AA Hydrangea
/34076AA Ivy
/34081AA Jasmine
/35073AA Juniper
/34083AA Lantana
/34089AA Lilac
/31131AA Lilies
73507 5AA Linden
/35082AA Magnolia
/34095AA Moonflower
/35085AA Mountainash
/34099AA Myrtle
/31143AA Nasturtium
/35088AA Norfolk Island Pine
/34102AA Oleander
/31147AA Orchids
/39001AA Ornamental Ferns
/35097AA Palm
/31149AA Pansles
/31156AA .Phlox
/35098AA Pine
/34113AA Pittosporum
/31159AA Poinsettia
/35101AA Poplar
/31284AA Primrose
/34088AA Privet
/34058AA Pyracantha
/34118AA Rhododendron
/31168AA Rubber Plant
Issued: 5-11-82
111-058102-26
-------
'35110AA
'31184AA
'31197AA
'35119AA
'34222AA
'31216AA
'31208AA
CRACAUA
[TBKABA
[RACAMA
[RAHBBA
[RAKAUA
[RAHAGA
[RAKAEA
•1RAHAHA
[RAWALA
[RAWAJA
LLAVARA
[LAJBCA
[RARACA
[RAHALA
[RAKBVA
ERAKBAA
IRAHBAA
[RAKAJA
IRAWAMA
IRAWAIA
IRACBWA
IRACATA
IRAKAKA
IRAKBPA
IRAKBHA
IRAVALA
IRAFAJA
IRAKASA
IRAKADA
ffiACCKA
IRACBQA
IRAKBYA
ILAVAHA
ILAVAPA
IRAKAZA
ILAVAKA
Site and Pest
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
African Violets cluster (continued)
Sago-Palm
Snapdragon
Sweet Pea
Sycamore
Trumpet-Flower
Tuberous Begonia
Violets
Apple aphid
Bagworm
Bean aphid
Black scale
Boisduval scale
Brown soft scale
California red
scale
Citricola scale
Citrophilus mealy-
bug
Citrus mealybug
Citrus red mite
Citrus rust mite
Co ttonycushion
scale
European fruit
lecanium
Forbes scale
Greedy scale
Hemispherical scale
Latania scale
Longtailed mealybug
Mexican mealybug
Monterey pine aphid
Oleander aphid
Oleander scale
Olive scale
Oystershell scale
Pine bark adelgid
Potato leafhopper
Putnam scale
Redwood scale
Rose aphid
Rosy apple aphid
San Jose scale
Sixspotted mite
Spruce spider mite
Tea scale
Texas citrus mite
0.75-1 lb/
100 gal
(25% WP)
(2-8 lb/
gal EC)
Use of emulsifiable concentrate for-
mulations limited to professional
pest control operators.
Foliar application.
Issued: 5-11-82
111-058102-27
-------
EPA Index to Pesticide Chemicals
Site and Pest
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
.LAVBEA
.RACBUA
.RAKAFA
LAVAJA
34036AA
3105 7AA
'31111AA
32005AA
34000AA
31208AA
RACAAA
.LAVAAA
:RAHBBB
:RAWAAA
.RACBWA
!RACCKA
.RAHAAA
iAVAPA
:LAVBEA
African Violets cluster (continued)
Pest list continued from previous page.
Twospotted spider
mite
Woolly apple aphid
Yellow scale
Yuma spider mite
Camellia
Carnation
Gladiolus
Ornamental Evergreens
Ornamental Woody Shrubs
Violets
Aphids
Spider mites
Black scale
(crawlers)
Mealybugs
Monterey pine aphid
Potato leafhopper
Rose aphid
Soft scale insects
Spruce spider mite
Twospotted spider
mite
0.4-0.8 Ib/A
(2-3% D)
0.25-0.75 lb/
100 gal
(25% WP)
or
0.25-1 lb/
100 gal
(4 Ib/gal EC)
Foliar application.
'33017AA
'33010AA
'33008AA
'33050AA
IQALAEA
(Lawns and Turf (including ground covers))
General Warnings and Limitations; Water material into soil immediately
after application. Do not enter treated areas or allow children and
pets on lawn for 24 hours and until grass has completely dried. Apply
granular formulations by fertilizer spreader and immediately after ap-
plication thoroughly water to wash granules into root zone. Water lawn
thoroughly before application when applying spray formulations.
Bermudagrass
Lawns
Ornamental Turf
St. Augustinegrass
Chinch bug
0.86-0.88 lb/ Application to established lawns.
5,000 sq.ft Apply around, not in, browned areas.
(1.5% D)
Issued: 5-11-82
111-058102-28
-------
EPA Index to Pesticide Chemicals
Site and Pest
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
Bermudagrass cluster (continued)
.QALAEA
.LAJARA
:RAWACA
:MOAAAA
Chinch bug
Bermudagrass mite
Rhodesgrass mealy-
bug
Thrips
0.83-0.95 lb/
5,000 sq.ft
(0.825-10% G)
or
0.9 lb/5,000
sq.ft
(0.54% P/T)
or
0.83 lb/100-
150 gal/
5,000 sq.ft
(25% WP)
(2-8 lb/
gal EC)
or
3.125 gal
2.5% EC/250
gal/5,000
sq.ft
(2.5% EC)
Use of 2 to 8 pound per gallon emul-
sifable concentrate formulations
limited to professional pest control
operators.
Application to established lawns and
turf. For chinch bug, apply when
activity or damage appears (yellow-
ing then browing of localized areas
often developing into spots, then
spreading through the lawn). Repeat
in 30 days. As a preventative for
chinch bug, apply as soon as average
daily temperatures reach 80 F
(26.7 C) and repeat at 60 day
intervals.
'30005AA
'30006AA
LTBGBKA
ETBGACA
FOREST, CHAPARREL, NONAGRICULTURAL AND WASTELANDS (includes tree planta-
tions and Christmas tree plantings)
Christmas Tree Plantations
Forest Plantings
European pine
shoot moth
Pine tip moth
0.75-1 lb/
5-50 gal/A
(25% WP)
(4-8 lb/
gal EC)
Use of emulsifiable concentrate
formulations limited to professional
pest control operators.
Foliar application. Repeat if
needed.
Issued: 5-11-82
III-058102-29
-------
Site and Pest
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Dosages and Tolerance, Use, Limitations
Formulation(s)
AERIAL, MOTHPROOFING AND TANK MIX APPLICATIONS
001500
AAAAAA
Aerial Application
900300
AAAAAA
Tank Mix
Refer to
AGRICULTURAL CROPS
Alfalfa, Alfalfa (seed crop), Almond, Apple,
Apricot, Beans (Dried-type), Beans (Dried-type)-
(seed crop), Beans (Succulent)(Snap), Beans (Suc-
culent) (Snap) (seed crop), Beans (Succulent)(Lima)
Beans (Succulent)(Lima)(seed crop), Beets, Beets
(seed crop), Cantaloupe, Cantaloupe (seed crop),
Cherry, Clover, Clover (seed crop), Corn (Field),
Corn (Field)(seed crop), Corn (Sweet), Corn
(Sweet)(seed crop), Cotton, Crabapple, Cucumber,
Cucumber (seed crop), Eggplant, Eggplant (seed
crop), Fig, Grapefruit, Grapes, Lemon, Lime, Nec-
tarine, Olive, Orange, Peach, Pear, Peas (Succu-
lent), Peas (Succulent)(seed crop), Pecan, Pep-
pers, Peppers (seed crop), Pimento, Pimento (seed
crop), Plum, Prune, Quince, Sorghum, Sorghum (seed
crop), Soybeans (Edible), Soybeans (Edible)(seed
crop), Spinach, Spinach (seed crop), Squash (Sum-
mer), Squash (Summer)(seed crop), Strawberry,
Sugar Beets, Sugar Beets (seed crop), Tangelo,
Tangerine, Tomato, Tomato (seed crop), Walnut,
Watermelon, Watermelon(seed crop)
Refer to
AGRICULTURAL CROPS
Almond, Apple, Apricot, Cherry, Crabapple, Grape-
fruit, Lemon, Lime, Nectarine, Olive, Orange,
Peach, Pear, Pecan, Plum, Prune, Quince, Tangelo,
Tangerine, Walnut
Issued: 5-11-82
III-058102-30
-------
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
j
Listing of Registered Pesticide Products by Formulation
90% technical chemical
carbophenothion (058102)
000476-02162
carbophenothion (058102) plus xylene range aromatic solvent (086803)
000476-015A6
25% formulation intermediate
carbophenothion (058102)
000476-01107
1.5% dust
carbophenothion (058102)
005778-00023
2% dust
carbophenothion (058102)
000476-01097
3% dust
carbophenothion (058102)
000239-01187 000279-02033
0.825% granular
carbophenothion (058102)
000539-00242 003442-00584
3% granular
carbophenothion (058102)
000539-00239
3.15% granular
carbophenothion (058102)
004185-00359
5% granular
carbophenothion (058102)
000476-01330 000829-00149
5.65% granular
carbophenothion (058102)
006720-00068
10% granular
carbophenothion (058102)
000476-01346 007001-00127
0.54% pelleted/tableted
carbophenothion (058102)
009545-00001
000476-01085 006735-00165
002393-00148
Issued: 5-11-82
111-058102-31
-------
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
Listing of Registered Pesticide Products by Formulation (continued)
25% wettable powder
carbophenothion (058102)
000239-01055 000279-01365 000476-01087 001202-000179
0.125 Ib/gal emulsifiable concentrate
carbophenothion (058102) plus petroleum distillate (063503)
008590-00203
2 Ib/gal emulsifiable concentrate
carbophenothion (058102) plus xylene range aromatic solvent (086803)
000476-01366 000476-01646 006720-00063
4 Ib/gal emulsifiable concentrate
carbophenothion (058102)
000239-01054 000279-01807 000476-01088 009859-00169
carbophenothion (058102) plus aromatic petroleum derivative solvent
(006501)
000239-01019 001202-00186
carbophenothion (058102) plus xylene (086802)
000635-00525
carbophenothion (058102) plus xylene range aromatic solvent (086803)
000279-01394 000476-01376 002935-00380 005905-00062
006735-00143
6 Ib/gal emulsifiable concentrate
carbophenothion (058102) plus xylene range aromatic solvent (086803)
000476-01541
8 Ib/gal emulsifiable concentrate
carbophenothion (058102)
002749-00203 003122-00015 006720-00096 007001-00111
009859-00028
carbophenothion (058102) plus aromatic petroleum distillate (006601)
009859-00165
carbophenothion (058102) plus xylene range aromatic solvent (086803)
002737-00030
2.5% emulsifiable concentrate
carbophenothion (058102) plus aromatic petroleum derivative solvent
(006501)
005778-00035
Issued: 5-11-82 111-058102-32
-------
EPA Index to Pesticide Chemicals
CARBOPHENOTHION
State Label Registrations
CA Reg. No.
000239-04143 000239-04153 000239-04154 000279-04005
000279-09531 001202-05016 007001-07669 007001-07685
007001-07687 011079-04796 011079-04797 011656-05894
FL Reg. No.
000829-06771 005778-03295 009169-09492 009859-09135
OR Reg. No.
001871-08925
TX Reg. No.
033722-03275
Issued: 5-11-82 III-O58102-33
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHEMICAL: CARBOPHENOTHION
S15B.120 - PRODUCT CHEMISTRY
Guideline Citation and
Name of Test
Product Identity:
61-1 - Identity of Ingredients
61-2 - Statement of Composition
61-3 - Discussion of Formation of
Ingredients
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
62-2 - Certification of Limits
62-3 - Analytical Methods for
Enforcement of Limits
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical State
63-4 - Odor
Test I/
Substance
TGAI
TGAI
TGAI y
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
Guidelines Are Data 2/ Footnote
Status Required Number
Yes No
R A/ n
R AT n
R A7 77
AT n
A7 n
R A7 n
R AT n
R AT n
R A/ n •
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHEMICAL:
CARBOPHENOTHION
S158.120 - PRODUCT CHEMISTRY
Guideline Citation and Test JL/
Name of Test Substance
Physic*
(Contir
63- 5
63- 6
63- 7
63- 8
63- 9
63-10
63-11
63-12
63-13
63-20
Other
64-1
il and Chemical Characteristics
lued)
- Melting Point TGAI
boning point IVJAI
Density, Bulk Density, or TGAI
Specific Gravity ^
- Solubility TGAI or PAI
- Vapor Pressure PAI
- Dissociation constant PAI
- Octa no I/water partition PAI
coefficient
- pH ' TGAI
- Stability TGAI
- Corrosion Characteristics TGAI
Requirements:
- Submittal of samples Choice
Guidelines Are Data 2/ Footnote
Status Required Number
Yes No
R n /E7
R A/ /_/
R A/ LJ
R AZ n
R A? n
A7 /7
R AZ n
R A7 /7
R 7^7 n
R 737. n
CR /7 A7
j_/ Composition: TGAI= Technical Grade of the Active Ingredient; PAI= Pure Active Ingredient
2/ Data must be submitted no later than May, 1987.
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
_!/ Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
§158-125 Residue Chemistry
171- 4 - Nature of Residue (Metabolism)
- Plants
- Livestock
171- 4 - Residue Analytical Method
- Plant residues and Animal
Residues
171- 4 - Storage Stability Data
171- 4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
- Root and Tuber Vegetable
' ° beets, garden
PAIRA
PAIRA and plant
metabolites
PAI
EP
Partially
Partially
TGAI and metabolites Partially
Partially
Partially
GS0108001
GS0108002
GS0108003*
GSO108004
GS0108005
GS0108006
GS0108007
GS0108008 through
GS0108027
GS0108028*
GS0108029*
GS0108030*
GS0108031*
GS0108032*
Yes3/
YesV
Yes6/
GS0108033
Yes7/
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
I/ Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
§158-125 Residue Chemistry
171- 4 - Magnitude of the Residue-
Residue Studies (continued)
0 sugar beets EP
- Leaves of Root and Tuber
Vegetables
0 garden beet tops EP
0 sugar beet tops EP
- Bulb Vegetables Group
0 onions (green and dry bulb) EP
- Leafy Vegetables
(Except Brassica Vegetables)
Group
0 spinach EP
- Legume Vegetables (Succulent
or Dried) Group
0 dry beans EP
Partially
Partially
Partially
Partially
No
Yes
GS0108034
GS0108035
GS0108036
GS0108037
GS0108038
GS0108039*
Yes£/
YesV
YesW
NO
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
I/
Data Requirement Composition
§158-125 Residue Chemistry
171- 4 - Maguitude of the Residue-
Residue Studies (continued)
0 lima beans EP
0 peas (succulent and dry) EP
0 snap beans (succculent form) EP v
0 soybeans (succulent form) EP
- Foliage of Legume Vegetables
Group
0 bean straw and vines EP
- Fruiting Vegetables (Except
Curcurbits) Group
0 eggplant EP
0 peppers EP
0 pimentos EP
0 tana toes EP
Does EPA Have Data
To Satisfy This
Requi rement? ( Yes ,
No or Partially)
Partially
Partial
Partially
Yes
Partially
Patially
Partially
No
Partially
Bibliographic
Citation
GS0108040
GS0108041
GS0108042
GS0108038
GS0108043
GS0108044
GS0108045
GS0108046
GS0108047
Must Additional
Data Be Submitted
Under FIFRA Sectioi
3(c)(2)(B)?2/
Yes13/
Yes55/
YesW
NO
YeslV
Yes16/
YesW
YesW
YeslV
Curcurbit Vegetables Group
0 cantaloupes
EP
No
Yes20/
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHIQN
Data Requirement
§158-125 Residue Chemistry
171- 4 - Magnitude of the Residue-
Residue Studies (continued)
0 cucumbers
0 squash
0 watermelon
- Citrus Fruits Group
0 grapefruit
0 lemons
0 limes
0 oranges
0 tangerines (including
tangelos)
- Pone Fruits Group
0 apples
0 crabapples
V
Composition
EP
EP v
EP
EP
EP
EP
EP
EP
EP
EP
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Partially
NO
Partially
Partially
Partially
Partially
Partially
Partially
Partially
NO.
Bibliographic
Citation
GS0108048
GS0108049
GS0108050
GS0108051
GS0108052
GS0108053
GS0108054
GS0108055
Must Additional
Data Be Submitted
Under FIFRA Sectioi
3(c)(2)(B)?2/
Yes21/
Yes22/
Yes2V
Yes24/
Yes25/
Yes26/
Yes27/
YesW
Yes29/
No30/
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Data Requirement
§158-125 Residue Chemistry
171- 4 - Magnitude of the Residue-
Residue Studies (continued)
0 pears
0 quince
- Stone Fruits Group
0 apricots
0 cherries
0 nectarines
0 peaches
0 plums (fresh prunes)
- Small Fruits and Berries Group
0 blueberries
0 grapes
0 strawberries
I/
Composition
EP
EP
EP
EP
EP
EP
EP
EP
EP
EP
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Partially
No
Partially
No
Partially
Partially
Partially
Yes
Partially
Partially
Bibliographic
Citation
GS0108056
GS0108057
GS0108058
GS0108059
GS0108060
GS0108061
GS0108062
GS0108063 .
GS0108064
Must Additional
Data Be Submitted
Under FIFRA Sectioi
3(c)(2)(B)?2/
Nq31/
Nq32/
No33/
Yes34/
Yes35/
Yes36/
Yes37/
No
YesW
Yes39/
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
I/
Data Requirement Composition
§158-125 Residue Chemistry
171- 4 - Magnitude of the Residue-
Residue Studies (continued)
- Tree Nuts Group
0 almond hulls EP V
0 pecans EP
0 walnuts EP
- Cereal Grains Group
0 Corn (kernels plus cob with EP
husks removed)
0 Sorghum (grain) EP
- Forage, Fodder, and Straw of
Cereal Grains Group
0 corn (forage) EP
0 sorghum (forage) EP
Does EPA Have Data
To Satisfy This
Requ i rement? ( Yes ,
No or Partially)
Partially
Partially
Partially
Partially
Partially
Partially
Partially
Bibliographic
Citation
GS0108065
GS0108066
GS0108067
GS0108068*
GS0108069
GS0108070*
GS0108071
GS0108072
GS0108071
GS0108072
Must Additional
Data Be Submitted
Under FIFRA Sectioi
3(c)(2)(B)?2/
YesW
Yes41/
Yes42/
Yes43/
YesW
YesfS/
Yes46/
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
I/
Data Requirement Composition
§158-125 Residue Chemistry
171- 4 - Magnitude of the Residue-
Residue Studies (continued)
- Non-grass Animal Feeds Group
0 alfalfa (fresh and hay) EP
0 clover EP
- Miscellaneous Crops
0 cottonseed (undelinted) EP
0 figs EP
0 olives EP
0 tea (dried) ' EP
- Meat/Milk/Poultry/Eggs
0 fat, meat, and meat by- TGAI or plant
products of cattle, goats, metabolites
hogs, and sheep
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Partially
Partially
Partially
Partially
Partially
Partially
Partially
Bibliographic
Citation
GS0108073
GSO 108074
GS0108075
GS0108076
GS0108077
GS0108078
GS0108079
GS0108080
GS0108081*
GS0108082*
GS0108083
GS0108084
GS0108085
GS0108086
Must Additional
Data Be Submitted
Under FIFRA Sectio
3(c)(2)(B)?2/
N0-7
YesW
Yees49/
YesSO/
YesSl/
Yes52/
YesSV
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
I/ Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
§158-125 Residue Chemistry
171- 4 - Magnitude of the Residues
Residue Studies (continued)
0 milk
poultry and eggs
TGAI or plant
metabolites
TGAI or plant
metabolites
Yes
No
GS0108087
GS0108088
GS0108089
No
£/ Composition: TGAI = Technical grade of the active ingredient; PAIRA = Pure active ingredient, radiolabelled; EP =
end-use product.
2/ Data must be submitted no later than May, 1987 .
£/ The uptake, distribution,.and metabolism of carbophenothion must be determined following foliar and soil application
of ring-labeled [14C]carbophenothion. The identities of residues (particularly unidentified water-soluble compounds)
in or on mature plants must be determined.
V Metabolism studies utilizing both poultry and ruminants must be submitted. Animals must be dosed with ring-labeled
t14C)carbophenothion, [I4]carbophenothion sulfoxide, and [14C]carbophenothion sulfone (the major plant residues)
in equal amounts and the distribution and characterization of residues must be determined in tissues and milk. If
ruminant metabolism is found to differ significantly from that in rats, then swine metabolism data will also be
required.
V A validated GC method which can be used to enforce the established tolerances for combined residues of
carbophenothion and its cholinesterase-inhibiting metabolites in the fat of meat must be submitted. If the requested
metabolism studies identify additional metabolites of concern, then new methodology may be required.
£/ Data demonstrating the stability of carbophenothion residues in or on representative plants (such as fruits, leafy
vegetables, root and tuber vegetables, and grain) and animal samples stored at freezing temperatures, for intervals
approximating the storage intervals of treated samples used to determine the magnitude of the residue, must be
submitted.
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR CARBOPHENOTHION
§158-125 Residue Chemistry
(continued)
2/ Data must be submitted reflecting residues in or on garden beet roots at regular intervals from 0-21 days after
foliar application (aerial and ground) of one of the EC formulations and the 25% WP formulation at 0.5 Ib ai/A and of
one of the D formulations at 1.2 Ib ai/A. Tests must be conducted in NY, OR, and WI.
^/ Residue data from sugar beet root samples, 14 days after foliar treatments and at harvest, after soil treatments at
1 Ib ai/A must be submitted. The studies should examine the effects of at-planting soil applications of the 10% G,
and foliar applications of D, WP, and EC formulations using aerial and ground equipment. The studies must be con-
ducted in the following states: CA, MN and MI.
•*,
A study must be submitted detailing the effects of processing sugar beet roots having measurable weathered residues (5
ppm) into pulp, molasses and refined sugar; if residues are found to concentrate in any of these processed products,
appropriate food/feed additive tolerances must be proposed.
£/ Data must be submitted reflecting residues in or on garden beet tops 21 days after: (i) ground and aerial foliar
applications of an EC formulation at 0.5 Ib ai/A (tests conducted in NY and WI): (ii) aerial and ground foliar
applications in WI and OR and aerial foliar applications in NY of the 25% WP formulation at 0.5 Ib ai/A; and (iii)
aerial and ground foliar applications of a D formulation at 1.2 Ib ai/A (tests conducted in NY, WI and OR).
Alternatively, feeding restrictions which may be imposed must be submitted.
D ata must be submitted reflecting residues in or on sugar beet tops: I) 14 days after ground and aerial foliar
applications of the 25% WP and one of the D formulations at 1 Ib ai/A (tests conducted in CA, MI, and MN); (ii) 14
days after aerial and ground foliar applications of one of the EC formulations at 1 Ib ai/A .(tests conducted in MI and
MN); and (iii) at intervals from immediately after treatment to harvest following soil applications of the 10% G formu-
lation at 1 Ib ai/A (tests conducted in CA, MI and MN). Alternatively, feeding and grazing restrictions may be
proposed.
The available data are adequate only to assess the registered use of EC formulations for ground and aerial application
in CA. The established tolerance will cover residues resulting from these uses.
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR CARBOPHENOTHION
§158-125 Residue Chemistry
(continued)
IV Residue data must be submitted reflecting in-furrow treatment with a representative D or EC formulation (2 Ib
ai/A) applied at-seeding green onions) and at transplanting (dry bulb onions). Tests must be conducted in CA
OR, ID or WA, NY, TX, and MI.
Residues data must be submitted from green and dry bulb onions sampled at several intervals after the following seed
treatments:
1. Slurry seed treatment at 0.375 Ib ai/25 Ib seed.
y
2. Dry seed treatment at 1 Ib ai/15 Ib seed. Data must reflect the use of methyl cellulose applied as a
sticker.
12/ Residues in or on spinach samples collected 0, 7, 14, and 21 days after foliar treatments with one of the D
formulations (1.2 Ib ai/A), the 25% WP (0.5 Ib ai/A), and one of the EC formulations (0.5 Ib ai/A) using both
aerial and ground equipment must be submitted. Tests must be conducted in CA, TX, NJ, and either MD or DE.
IV Data must be submitted reflecting residues in or on succulent lima beans (beans and pods) 7 days after the last two
applications of one of the EC and 25% WP formulations at 0.75 Ib ai/A/application and one of the D formulations at
1.2 Ib/A/application. Both ground and aerial application data must be submitted. Tests must be conducted in CA, DE
and WI.
4 Data must be submitted reflecting residues in or on succulent snap beans 7 days after the last of two applications
of one of the EC and the 25% WP formulations at 0.75 Ib ai/A/application and one of the D formulations at 1.2 Ib
ai/A application. Both ground and aerial application data must be submitted. Tests must be conducted in CA, FL,
NY, OR, and WI . (EC formulation data are not required from OR or CA. )
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TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
§158-125 Residue Chemistry
(continued)
15/ Data must be submitted reflecting residues in or on bean vines and straw (hay) 21 days after the last of two
applications of one of the EC and the 25% WP formulations at 0.5 Ib ai/A/application and one of the D formulations
at 0.6 Ib ai/A/application. Both aerial and ground application data must be submitted. Tests must be conducted
in CA, DE, and WI (lima beans); CA, FL, NY, OR, and WI (snap beans); and CA, ID, MI, ND, and NE (dried beans). [EC
formulation test data are not required for NE.] A tolerance must be proposed for bean vines; alternatively feeding
and grazing restrictions may be proposed.
16/ Residue data must be submitted reflecting foliar application of one of the D formulations (1.2 Ib ai/A), the 25% WP
(1 Ib ai/A), and one of the EC formulations (1 Ib ai/A) on eggplant made 7 days prior to harvest using ground and
aerial equipment. Tests must be conducted in FL and NJ.
IV Residue data must be submitted reflecting foliar application of one of the D formulations (1.2 Ib ai/A), the 25%
WP (1 Ib ai/A), and one of the EC formulations (1 Ib ai/A) made 7 days prior to harvest using ground and aerial
equipment. Tests must be conducted in FL, CA and TX.
Residue data must be submitted reflecting foliar application with one of the D formulations (1.2 Ib ai/A), the 25%
WP (1 Ib ai/A), and one of the EC formulations (1 Ib ai/A) made 7 days prior to harvest using ground and aerial
equipment. Tests must be conducted in the major green pepper production areas (FL, CA, and TX). Alternatively,
the requested pepper data may be translated to pimentos.
Residue data must be submitted reflecting foliar application of one of the D formulations (1.2 Ib ai/A), the 25%
WP (1 Ib ai/A), and one of the EC formulations (1 Ib ai/A) made 7 days prior to harvest using ground and aerial
equipment. Tests must be conducted in CA, and FL.
Residue data must be submitted involving carbophenothion residues in or on the processed products of tomatoes
(pomace, puree, catsup, and juice) processed fron field-treated tomatoes which contain measurable weathered
residues.
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TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
§158-125 Residue Chemistry
(continued)
2Q/ Data must be submitted reflecting residues in or on cantaloupes 5 days after foliar application with one of the
D formulations (1.2 Ib ai/A), one of the EC formulation (1 Ib ai/A), and the 25% WP (1 Ib ai/A) using
both ground and aerial equipment. Tests must be conducted in CA and TX.
2I/ Data must be submitted reflecting residues in or on cucumbers 7 days after foliar application of one of the EC, one
of the D, and the 25% WP formulations at 1 Ib ai/A using both ground and aerial equipment. Tests must be conducted
in CA, FL, MI, NC or SC, and TX.
22/ Data must be submitted reflecting residues in or on summer squash 7 days after foliar application with 25% WP, one
of the D, and one of the EC formulations at 1 Ib ai/A using ground and aerial equipment. Tests must be conducted in
FL, TX, and one representative eastern state.
2V Data must be submitted in or on watermelon 5 days after foliar application with the 25% WP, one of the EC
formulations at 1 Ib ai/A, and one of the D formulations at 1.2 Ib ai/A using ground and aerial equipment.
Tests must be conducted in FL, GA or SC, and TX.
24/ Sufficient data are not available to determine the adequacy of the established tolerances and label directions.
The requested field residue data and processing study for oranges will be translated to grapefruit. Note that
additional grapefruit data will be required to establish a crop group tolerance.
25/ Residue determinations on whole lemons after the last of five foliar applications (at 30-day intervals) with the
25% WP and one of the EC formulations must be submitted. Samples must reflect residues on the day of the last of
five 2.5 Ib ai/A treatments, 14 days after the last of five 3.75 Ib ai/A treatments, and 30 days after the last of
five 5 Ib ai/A treatments frcm tests conducted in AZ and CA.
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TABLE A
GENERIC DATA REQUIREMENTS FDR CARBOPHENOTHION
§158-125 Residue Chemistry
(continued)
Residue determinations on whole limes must be submitted after the last of five foliar applications (at 30-day
intervals) with the 25% WP and one of the EC formulations. Samples must reflect residues on the day of the last
of five 2.5 Ib ai/A treatments, 14 days after the last of five 3.75 Ib ai/A treatments, and 30 days after the last
of five 5 Ib ai/A. treatments from tests conducted in FL.
Residue determinations on whole oranges must be submitted after the last of five foliar applications with the 25%
WP and one of the EC formulations. Samples must reflect residues on the day of the last of five 2.5 Ib ai/A
treatments, 14 days after the last of five 3.75 Ib ai/A treatments, and 30 days after the last of five 5 Ib ai/A
treatments from tests conducted in FL and CA. ^
Residue data pertaining to dried pulp, peel, oil, molasses, and juice processed from field-treated oranges containing
detectable weathered residues must be submitted. This processing study will be translated to grapefruit, lemons,
limes, and tangerines.
Sufficient data are not available to determine the adequacy of the established tolerances and label directions.
Field residue data and the processing study requested for oranges will be translated to tangerines.
Data must be submitted reflecting residues in or on apples subjected to aerial and ground foliar spray applications
of the 25% WP and one of the EC formulations at 1.25 Ib ai/A beginning at petal fall and continuing at 10-day
intervals until 30 days prior to harvest. Tests must be conducted in WA, MI, and NY.
Data must be submitted reflecting residues in or on apples subjected to aerial and ground foliar applications of one
of the D formulations at 1.2 Ib ai/A beginning at the prepink stage and continuing at 10-day intervals until 30 days
prior to harvest. Tests must be conducted in WA, MI and NY.
Residues must be determined in wet and dry pomace and juice processed from apples bearing measurable weathered
residues. If residues are found to concentrate in any of these processed products, appropriate food/feed additive
tolerances must be proposed.
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TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
§158-125 Residue Chemistry
(continued)
3Q/ NO data are available pertaining to residues of carbophenothion in or on crabapples; however, the data
requested for apples will be translated to crabapples and used to evaluate the established tolerance.
31/ The available data are insufficient to assess the established tolerance for residues of carbophenothion in or on
pears. However, no additional data are required because the data requested for apples will be translated to pears.
It must be noted that translated data may not be used for establishment of a crop group tolerance. Therefore,
to establish a crop group tolerance for pane fruits, additional data for pears will be required.
V
32/ NO data are available pertaining to residues of carbophenothion in or on quinces; however, the data requested for
apples will be translated to quinces and will be used to evaluate the established tolerance.
33/ xhe available data do not support the established tolerance for carbophenothion residues in or on apricots. Data
requested for peaches will be translated to apricots and used to evaluate the established tolerance.
_3_V Residue data must be submitted from sweet and sour cherry samples taken at several intervals, up to and including
30 days after multiple (5-8) aerial and ground foliar sprays of the 25% WP and a representative EC formulation at
2 Ib ai/A. The applications must be spaced 10 days apart. Separate tests of a representative D formulation must
be made at 10-day intervals at 1.8 Ib ai/A. Studies on sweet cherries must be conducted in CA, MI, and either OR
or W/V. Sour cherry studies must be conducted in MI and NY.
3V The available data do not support the established tolerance for carbophenothion residues in or on nectarines. Data
requested for peaches will be translated to nectarines and will be used to evaluate the established tolerance.
36/ Residue data must be submitted from samples taken at several intervals, up to and including 30 days after multiple
(5-8) aerial and ground foliar sprays of the 25% WP and a representative EC formulation at 2 Ib ai/A. The
applications must occur 10 days apart. Separate tests of either the 2% or 3% D formulation, applied at 10-day
intervals at 1.8 Ib ai/A, must be conducted. Tests must be conducted in CA, PA, and SC.
-------
TABLE A
GENERIC DATA REQUIREMENTS POR CARBQPHENOTHION
§158-125 Residue Chemistry
(continued)
37/ Data requested for cherries will be translated to plums and will be used to evaluate the established tolerance.
In addition, residue data are required from dried prunes processed fromtn plums having measurable weathered
carbophenotion residues. Procurement of such plums may require that exaggerated treatment rates be used.
It must be noted that translated data may not be used to support the establishment of crop group tolerance.
Additional data for plums are required to support a crop crop tolerance.
38/ Residue data must be submitted concerning grape samples harvested 30 days after field-treatment at 0.5 Ib ai/A with
the 25% VIP and a representative EC formulation. Both ground and aerial application methods must be tested. The
2% or 3% D formulation must also be tested at 1 Ib ai/A. All studies must be conducted in CA. Also required is a
study to determine the magnitude of residues remaining in or on raisins, wet and dry grape pomace, raisin waste and
grape juice processed from grape samples bearing measurable weathered carbopheriothion residues.
39/ Residue data must be submitted for strawberry samples harvested 3 days following treatment with the 25% WP and a
representative EC formulation at 0.5 Ib ai/A; both ground and aerial application data must be submitted. The studies
must be done in CA.
40/ Sufficient data are not available to assess the adequacy of the established tolerance and label directions. The
following additional data are required: Residue analysis of almond nutmeats and hulls 7 days following a single
application fo the 25% WP at 2.5 Ib ai/A, the 3% D at 1.8 Ib ai/A, and an EC formulation at 2.5 Ib ai/A. Applications
must be made using aerial and ground equipment in CA. These must follow a single prebloom treatment with an EC
formulation at 0.5 Ib ai/100 gal. Note also that an almond nutmeat tolerance must be established.
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
§158-125 Residue Chemistry
(continued)
Residue data must be submitted reflecting multiple foliar applications with one of the D formulations at 1.8 Ib '
ai/A, the 25% WP at 2.5 Ib ai/A and one of the EC formulations at 2.5 Ib ai/A using both ground and aerial equipment.
Tests must be conducted in AL, GA, and LA.
Residue data must be submitted reflecting multiplevfoliar applications with one of the D formulations at 1.8 Ib
ai/A and with the 25% WP and one of the EC formulations at 2 Ib ai/A using both ground and aerial equipment. Tests
must be conducted in CA and OR.
Sufficient data are not available to assess the adequacy of the established tolerance. In addition, the tolerance
definition for corn (kernels plus cobs with husks removed) is inappropriate for field corn grain. The present
tolerance definition is applicable only to sweet corn. The following additional data are required:
0 Data reflecting residues in or on field corn grain and sweet corn (kernels plus cobs with husks removed) at
weekly intervals from 0-21 days after a single foliar treatment (ground-applied) with a registered D, the 25% WP,
and a registered EC formulation at 1 Ib ai/A. Field corn tests must be conducted in MN, NE, and either IL, IN,
or IA. Sweet corn tests must be conducted in MN or WI, OR or WA, FL CA, and NY. Appropriate PHIs must be proposed
Also, a tolerance for field corn grain must be proposed.
0 Data reflecting residues in or on crude and refined oil from field corn grain bearing measurable
weathered residues.
0 Data reflecting residues in or on cannery waste processed from sweet corn bearing measurable
weathered residues.
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TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
§158-125 Residue Chemistry •
(continued)
Sufficient data are not available to assess the adequacy of the established tolerance and label directions. The
following additional data are required:
Data reflecting residues at weekly intervals from 0-21 days following single aerial applications of the 2% or 3% D,
25% WP, and any 4-8 Ib/gal EC at 1 Ib ai/A. Tests must be conducted in KS, NE, and TX.
Data reflect residues at weekly intervals from 0-21 days following two applications of the formulations listed above
at 0.5 Ib ai/A. Test locations must include KS, NE, and TX.
Data reflecting residues in or on flour and milled products processed from sorghum grain having measurable weathered
residues. If residues are found to concentrate in any of these processed products, appropriate food additive
tolerance must be proposed. (The requested data for flour and milled products processed from corn grain may be
translated to sorghum grain.)
Data must be submitted reflecting residues 21 days after a single application of the 2% D or 3% D, 25% WP, and any
4-8 Ib/gal EC using ground equipment at 1 Ib ai/A; corn forage, silage, and fodder must be sampled. Tests must be
conducted in northeastern, north central, and midwestern locations which are the major growing regions, such as IA
MN, and NY. Tolerances must be proposed for corn fodder and silage. Alternatively, feeding and grazing
restrictions may be proposed.
Data must be submitted reflecting residues in or on sorghum forage, fodder and silage harvested 21 days after a
single aerial application at 1 Ib ai/A and after two aerial applications at 0.5 Ib ai/A of the 25% WP and one of the
registered EC and D formulations. Tests must be conducted in KS, NE, and TX. Tolerances must be proposed for
sorghum fodder and silage. Alternatively, feeding and grazing restrictions may be proposed.
-------
10
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
§158-125 Residue Chemistry
(continued)
47/ Data must be submitted reflecting residues in or on alfalfa (fresh), alfalfa hay, and alfalfa seed samples 28 days
after the last of three successive aerial applications (eight in CA) made during one growing season. Tests must
reflect use of the 25% WP, one of the D, and one of the EC formulations at 1 Ib ai/A in CA, NE, and WI. Upon
submission of the data pertaining to alfalfa seed, a tolerance for carbophenothion residues in or on this commodity
may be needed if residues in this commodity exceed those of alfalfa hay (5 ppm). A processing study is needed to
determine residues in meal processed from field-treated seed containing detectable weathered residues; if residues
are found to concentrate in meal, a feed additive tolerance must be proposed.
48/ The available data do not support the established tolerances for carbophenothion residues in or on clover (fresh)
or clover hay. However, no additional data will be required specifically for these commodities because the requested
data pertaining to combined residues of carbophenothion in or on alfalfa (fresh) and alfalfa hay, when submitted, will
be translated to clover (fresh) and clover hay. Note that translatable are not useful for the establishment of a
group tolerance, must a group tolerance be desired, additional data will be required for clover (fresh) and clover
hay.
Data must be submitted reflecting residues in or on undelinted cottonseed at harvest following 10 weekly
applications of the 25% WP, a registered D, and a registered EC formulation; treatments must begin 7 days after
planting. Both aerial and ground application data must be submitted. Tests must be conducted in CA, MS
and TX.
Data are required reflecting residues in or on hulls, meal, soapstock, and oil (crude and refined) processed from
cottonseed containing measurable weathered residues (exaggerated rates may be necessary to obtain detectable
residues). If residues are found to concentrate in any of these processed products, appropriate food/feed additive
tolerances must be proposed.
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TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
§158-125 Residue Chemistry
(continued)
Data must be submitted reflecting residues in or on fresh figs harvested 7 days after the last of two foliar
applications (made 7 days apart) of the 25% WP and one of the registered EC formulations at 2.5 Ib ai/A, and one
of the registered D formulations at 2.4 Ib ai/A. Trials must be conducted in CA. Data must reflect both aerial and
ground applications. Data reflecting residues in or on dried figs processed from fresh figs having measurable
weathered residues must be submitted. If residues are found to concentrate in dried figs, an appropriate food
additive tolerance may be needed if residues exceed those on fresh figs.
Data must be submitted reflecting residues in or on green and ripe olives at 0, 30, and 60 days following two
foliar applications with the 25% WP and an EC formulation at 9 Ib ai/A using ground and aerial equipment. Tests
must be conducted in CA.
Data" pertaining to carbophenothion residues in or on oil processed from field-treated ripe olives which contain
detectable weathered residues must be submitted. If residues are shown to concentrate, a food additive tolerance
must be proposed.
Residue data for dried tea produced from foliage treated at 1, 4, and 6 weeks prior to harvest at 0.27 Ib ai/A
with the 2 Ib/gal EC formulation must be submitted. Tests must be conducted in Pakistan, India, and Sri Lanka.
The interval between the final dosage and slaughter in the feeding study must be provided. A 24-hour interval is
required. The registrant must petition the Agency to establish a tolerance of 0.05 ppm in the meat and meat
by-products of cattle, goats, hogs, horses and sheep.
Poultry feeding studies at 1.6 ppm, 4.8 ppm, and 16 ppm for 28 consecutive days and subsequent analysis on eggs
(collected twice daily during the treatment period) and in poultry tissues (muscle, liver, and fat from animals
slaughtered within 24 hours of the final feeding) must be submitted.
data are adequate to support the use on succulent peas; however in order to maintain the use on dried peas the
registrant must petition the Agency for establishment of a tolerance. A tolerance proposal of 0.1 ppm will be
adequate to cover residues resulting from this use.
Data submitted by Stauffer Chemical Co. Data may be compensable.
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TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Data Requirement
Does EPA Have Data
To Satisfy This
V Use V Requirement? (Yes, Bibliographic
Composition Pattern No or Partially) Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
158.130 Environmental Fate
DEGRADATION STUDIES-LAB;
161-1 - Hydrolysis
Photodegradat ion
161-2 - In Water
161-3 - On Soil
161-4 - In Air
METABOLISM STUDIES-LAB;
162-1 - Aerobic Soil
162-2 - Anaerobic Soil
162-3 - Anaerobic Aquatic
162-4 - Aerobic Aquatic
MOBILITY STUDIES;
163-1 - Leaching and
Adsorption/Desorption
163-2 - Volatility (Lab)
163-3 - Volatility (Field)
TGAI or PAIRA A,B,G,H
No
TGAI or PAIRA A,B,G No
TGAI or PAIRA A,G ^ No
TGAI or PAIRA Not Applicablr
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
A,B,G,H
A
G
Not Applicable
No
No
No
TGAI or PAIRA A,B,G,H
TEP
TEP
A
A
No
No
No
Yes
Yes
Yes
Yes
Yes£/
Yes
Yes
Yes
Yes
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TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Data Requirement
Composition
_V
Use _
Pattern
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
158.130 Environmental Fate •
(continued)
DISSIPATION STUDIES-FIELD;
164-1 - Soil
164-2 - Aquatic (Sediment)-
164-3 - Forestry
164-4 - Combination and
Tank Mixes
164-5 - Soil, Long-Term
ACCUMULATION STUDIES;
165-1 - Rotational Crops
(confined)
165-2 - Rotational Crops
(Field)
165-3 - Irrigated Crops
165-4 - In Fish
165-5 - In Aquatic Non-Target
Organisms
TEP
TEP
TEP
A,B,H
Not Applicable
G
TEP A
PAIRA A
TEP A
TEP Not Applicable
TGAI or -PAIRA A,B,G
TEP G
No
No
No
No
No
No
No
Yes
Yes
Reserved^/
Yes6/
Yes
Yes7/
Yes
Yes
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TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
158.130 Environmental Fate
(continued)
^/ Composition: TGAI = Technical grade of the active ingredient; PAIRA = Pure active ingredient, radiolabelled,
TEP = Typical end-use product.
V The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
2/ Data listed under 161-1, 161-2, 161-3 and 163-1 must be submitted no later than November, 1984 ;
data listed under , 162-1, 162-2, 162-3, 164-1 and 164-3 must be submitted no later than May, 1986 ;
all other data listed in Table must be submitted no later than May, J987 .
£/ Data are needed to support field and vegetable crop uses only.
V Data requirements for combinations and tank mixes are reserved.
_£/ Data may be required based on the results from the field dissipation/aerobic soil metabolism studies.
]/ For crops rotated on treated areas any one of the following will apply:
a. A tolerance must be obtained for the rotated crop.
b. The product label must include a restriction against the rotation of crops used for food or feed on treated
areas.
c. Data must be provided to determine time intervals at which crops planted on treated areas will be free of
pesticide residues.
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TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Data Requirement
Composition
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
_V Use _2/ Requirement? (Yes, Bibliographic Under FIFRA Section
Pattern No or Partially) Citation 3(c)(2)(B)?3/
§158-140 Reentry Protection
132-1 - Foliar Dissipation
132-2 - Soil Dissipation
133-3 - Dermal Exposure
133-4 - Inhalation Exposure
TEP
TEP
TEP
TEP
A,B,H
A,B,H
A,B,H
A,B,H
No
No
No
No
YesV
Yes4/
YesV
_V Composition: TEP = Typical end-use product
_£/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Ourdcor; I=Indoor.
«i
_V Data must be submitted no later than December, 1986.
V A 48 hour reentry interval is imposed for all uses pending the receipt and evaluation of reentry data (use of
protective clothing will allow reentry in less than 48 hours).
V will be met by data required in 164-1.
_6_/ For the lawn and turf use, the registrant is required to propose an acceptable reentry interval based on one
of the following: (a) data on dissipation of foliar and/or soil residues of carbophenothipn (decline curve),
on human exposure to those residues, and on toxicity of carbophenothion; or (b) determination of that time
time beyond which there are no detectable, dislogeable residues remaining on the turf/lawn area.
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TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
Use 2/ Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition1/ Pattern No or Partially) Citation 3(c) (2) (B)?3/
158.135 Toxicology
ACUTE TESTING:
81-1
81-2
81-3
81-6
81-7
- Acute Oral Toxic ity- Rat
- Acute Dermal Toxic ity-
Rabbit
- Acute Inhalation Toxicity-
Rat
- Dermal Sensitization
- Delayed
Neurotoxicity - Hen
TGAI
TGAI
TGAI
TGAI
TGAI
A,B,G,H Partial 00089847
A,B,G,H No
A,B,G,H No
A, B, G, H No
A,B,G,H Yes GS010095*
Yes4/
Yes
Yes
Yes
No
SUBCHRONIC TESTING:
82-1
82-2
82-3
82-4
- 90-Day Feeding -
Rodent
Non-rodent
- 21-Day Dermal - Rabbit
- 90-Day Dermal - Rabbit
- 90-Day Inhalation -
TGAI
TGAI
TGAI
TGAI
A,B Partial 00093054
Partial 00089852
A,B,G,H Not Required
A,B,G,H Not Required
A,B,G,H Not Required
Yes5/
No6/
Rat
82-5 - 90-Day Neurotoxicity-
Hen/Mammal
TGAI
A,B,G,H
Not Required
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR CARBOPHENOTHION
Use £/
Data Requirement Composition^/ Pattern
158.135 Toxicology
(continued)
CHRONIC TESTING:
83-1 - Chronic Toxicity -
2 species: Rodent (rat) TGAI A
Non- rodent (dog)
83-2 - Oncogenicity -
2 Rat TGAI A
Mouse
83-3 - Teratogenicity -
1st species TGAI A
2nd species
83-4 - Reproduction - Rat TGAI A
2-generation
MUTAGENICITY TESTING
84-2 - Gene Mutation TGAI A,B,G,H
84-2 - Chromosomal Aberration TGAI A,B,G,H
84-2 - Other Mechanisms of TGAI A,B,G,H
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Partial
Yes
Partial
No
Partial
No
Yes
No
No
No
Must Additional
Data Be Submitted
Bibliographic Under FIFRA Section
Citation 3(c) (2) (B)?3/
00093076 Yes7/
00093076 No
00093076 Yes8/
Yes
GS010096 Yes
Yes
00036074 No
. Yes
Yes
Yes
Mutagenicity
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR CARRQPHENOTHION
Does EPA Have Data Must .Additional
To Satisfy This Data Be Submitted
Use _2/ Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement CompositionV Pattern No or Partially) Citation 3(c) (2) (B)?3/
158.135 Toxicology
(continued)
SPECIAL TESTING
85-1 - General Metabolsm PAI or PAIRA A Yes 00093111 No
85-2 - Domestic Animal Safety Not Required
V Composition: TGAI: Technical grade of the active ingredient; PAI = Pure active ingredient; PAIRA = Pure active
ingredient, radiolabelled.
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
V Data must be submitted no later than May, 1987.
^/ Although adequate acute toxicity data exist to place technical carbophenothion in Toxicity Category I on the basis
of acute oral and dermal toxicity [GS010097, 00089847], current technical carbophenothion is reported to be 92.35%,
whereas technical
carbophenothion used for acute toxicity testing was 95%. Analysis of the current material indicates the presence
of several contaminants that were not reported to be present in the technical product used for testing.
5/ if a 2-year chronic feeding study with rats is presented, the 90-day study will not be required.
^/ This study will not have to be repeated since there is an adequate 2-year dog study on file with the Agency.
~[/ The study can only be considered supplementary since there were insufficient data generated with respect to
hematology, urinalysis, and clinical biochemistry, organ weights and other aspects.
£/ The study is considered supplementary since an insufficient number of rats survived the two-year dosing period and
there were an insufficient number of tissues available to assess an oncogenic effect of the test material. Several
of the rats from each group were of limited usefulness for histopathology because of autolysis.
* Data submitted by Stauffer Chemical Co. Data may be compensable.
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Use V
Data Requirement Composition^/ Pattern
158.145 Wildlife and
Aquatic Organisms
AVIAN AND MAMMALIAN TESTING
71-1 - Acute Avian Oral TGAI A,B,G,H
Toxic ity
71-2 - Avian Subacute Dietary TGAI A,B,G,H
Toxic ity
71-3 - Wild Mammal Toxicity TGAI A,B,G
71-4 - Avian Reproduction TGAI A,B,G
71-5 - Simulated and Actual TEP A,B,G
Field Testing -
Mammals and birds
AQUATIC ORGANISM TESTING
72-1 - Freshwater Fish Acute TGAI A,B,G,H
Toxicity
72-2 - Acute Toxicity To Fresh- TGAI A,B,G,H
water Invertebrates
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
No
Partially
Reserved5/
Reserved5/
Reserved5/
Yes
Partially
Bibliographic
Citation
00093046
00093133
GS0108091
00093046
GS0108090
GS0108090
00002875
Must Additional
Data Be Submitted
Under FIFRA Section
3(cj(2)(B)?3/
Yes
Yes4/
Nq8_/
Yes4/
72-3 - Acute Toxicity To Est- TGAI
uarine and Marine Organisms
72-4 - Fish Early Life
Stage and Aquatic
Invertebrate Life-Cycle
TGAI
A,BV
A,R,G
Yes
00066341
Reserved5/6/
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Data Requirement
Composition!/
Use
Pattern
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
158.145 Wildlife and
Aquatic Organisms
(continued)
72-5 <- Fish - Life-Cycle
72-6 - Aquatic Organism
Accumulation
72-7 - Simulated Actual
Field Testing -
Aquatic Organisms
TGAI
TEP
A,B,G
TGAI, PAI or A,B,G
Degradation
Product
A,B,G
Reserved^/
Reserved^/
Reserved^/
_!/ Composition: TGAI = Technical grade of the active ingredient; PAI = pure active ingredient;
TEP = Typical end-use product;
£/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food Crop; C=Aquatic, Food
Crop; D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry, H=Domestic Outdoor; I=Indcor.
V Data must be submitted no later than May, 1987 .
^/ Although the study cited is scientifically sound and acceptable for use in a hazard assessment, it does not fulfill
guideline requirements.
^/ Reserved studies are pending the outcome of one or more of the following: (1) lower tier testing, (2) Environmental
Fate Profile, (3) Toxicology Branch review, and (4) any information and/or data that the registrant may be able to
retrieve from its archives that was not reviewed under this standard.
6/ 72-5 Marine-estuarine chronic studies indicated impairment at low test levels. If the Environmental Fate Profile
indicates an aquatic contamination potential then this study will be required.
2/ Acute estuarine and marine studies are indicated for crops which are grown in excess of 300,000 acres in coastal
counties. However, this requirement has been fulfilled but has not been requested. The request could occur after
the environmental fate profile is completed.
£/ Each of these citations'stand alone to fulfill the data requirement.
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR CARBOPHENOTHION
Data Requirement
Composition^/
Does EPA Have Data
To Satisfy This
Use _£/ Requirement? (Yes,
Pattern No or Partially)
Must Additional
Data Be Submitted
Bibliographic Under FIFRA Section
Citation 3(c)(2)(B)?3/
158.150 Plant Protection
121-1 - TARGET AREA ' EP
PHYTOTOXICITY
NONTARGET AREA PHYTOTOXICITY
TIER I
122-1 - Seed Germination/ TGAI
Seedling Emergence
122-1 - Vegetative Vigor TGAI
122-2 - Aquatic Plant Growth TGAI
TIER II
123-1 - Seed Germination/ TGAI
Seedling Emergence
123-1 - Vegetative Vigor TGAI
123-2 - Aquatic Plant Growth TGAI
TIER III
124-1 - Terrestrial Field TEP
124-2 - Aquatic Field TEP
No
No
No
No
No
No
No
No
No
No4/
Nq4/
Nq4/
NO4/
No4/
No4/
Nq4/
No4/
NO4/
x/ Composition: TGAI = Technical grade of the active ingredient; TEP = Typical end-use product; EP= End-use product.
^/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food Crop; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
3/ Data must be submitted no later than Reserved
^/ These requirements are generally waived unless it is believed that there is a phototoxicity problem.
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Data Requirement
Composition^/
Does EPA Have Data
To Satisfy This
Use £/ Requirement? (Yes,
Pattern No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
§158.155 Nontarget Insect
NONTARGET INSECT TESTING -
POLLINATORS;
141-1 - Honey bee acute
contact toxicity
141-2 - Honey bee - toxicity
of residues on
foliage
TGAI
TEP
A,B,G,H
A,B,G,H
Yes
Yes
00036935
05001991
00060628
05000837
05008989
No
No7/
141-4 - Honey bee subacute
feeding study Reserved^/
141-5 - Field testing for
pollinators TEP
A,B,G,H
No
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CARBOPHENOTHION
Data Requirement
Compos i t ion
Does EPA Have Data
To Satisfy This
Use ^/ Requirement? (Yes,
Pattern No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
§158.155 Nontarget Insect
(continued)
NONTARGET INSECT TESTING -
AQUATIC INSECTS;
142-1 - Acute toxicity to
aquatic insects
142-2 - Aquatic insect
life-cycle study
142-3 - Simulated or actual
field testing for
aquatic insects
Reserved^/
Reserved^/
Reserved**/
143-1 - NONTARGET INSECT TESTING -
thru PREDATORS AND PARASITES
143-3
Reserved^/
£/ Composition: TGAI = Technical grade of the active ingredient; TEP = Typical end-use product
^/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Ourdoor; I=Indoor.
jV Data must be submitted no later than Reserved .
£/ Reserved pending development of test methodology.
£/ Data from 1st and 2nd tier studies do not indicate the need for field studies.
£/ Reserved pending Agency decision as to whether the data requirement should be established.
7/ Each of these citations stand alone to fulfill the data requirement.
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CARBOPHENOTHION
§158.120 - PRODUCT CHEMISTRY
Guideline Citation and
Name of Test £
Product identity:
fl 1 T*J J- ' 1. -C T *^ •! j-ivil- rt
Di— i identity or ingredients
61-2 - Statement of Composition
61-3 - Discussion of Formation of
Ingredients
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
62-2 - Certification of Limits
DZ j — Analytical netnoos tor
Enforcement of Limits
Physical and Chemical Characteristics
DJ Z ~ V_OJ.OjL
63 3 "~ Physical Stcits
Test I/
Jubstance
MT>
nf
MP
MP
MP
MP
MD
MT3
rllr
MD
rlJr
MD
Guidelines
Status
R
R
R
R
i Are Data 2/ Footnote
Required Number
Yes No
fvl f 1
IXJ I J
[xi n
[x] [ ]
[x] n
tx] n
r"3"i r~i
IXJ l J
r"^i r~i
IXJ 1 J
r77i f 1
IXJ 1 J
F vl f~l '
IXJ l J
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CARBOPHENOTHION
§158.120 - PRODUCT CHEMISTRY (Con't)
Guideline Citation and
Name of Test
Physical and Chemical Characteristics
(Continued)
63—7 Density / Bulk Density, or
Specific Gravity
63-12 - pH
63 14 — Oxidizing or Reducing
Action
£O_1 C _ C*1 -ammoN-i 1 -I 4-t7
oj J.J r-Lcuiuiiduxxi.uy
£•} 1 f. I?vr^l /-v-laK-i 1 -i 4-\7
DJ J.D iLxpj.oaaDi±it.y
£o ~\ *7 _ . Cf-/-\va/^Q Ct-aK-i 1 -i l-x/
DJ LI — ocojraye ocaDixioy
iro^l p \7-i c/^/^o-i *-\7
DJ J.O viscosity
63-19 - Miscibility
Other Requirements:
64-1 - Submittal of samples
Test I/
Substance
MP
MP
MP
MP
MP
MP
MP
MP
MP
PAI
Guidelines
Status
R
R
CR
CR
R
R
CR
CR
R
CR
Are Data Footnote
Required 2/ Number
Yes No
[x]
[x]
[x]
[x]
[x]
[x]
[x]
[x]
[x]
n
[ 1
[~]
n
[ 1
[ 1
n
1 1
n
n
[x]
I/ Composition: MP= Manufacturing-Use Product; PAI= Pure Active Ingredient.
2/ Data must be submitted no later than November, 1984 .
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHEMICAL CARBOPHENOTHION
Data Requirement
Composition
I/
Does EPA Have Data
To Satisfy This
Requ irement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
§158.135 Toxicology
ACUTE TESTING
81-1 - Acute Oral Toxicity-Rat MP
81-2 - Acute Dermal Toxicity- MP
Rabbit
81-3 - Acute Inhalation Toxicity- MP
Rat
81-4 - Primary Eye MP
Irritation - Rabbit
81-5 - Primary Dermal MP
Irritation
81-6 - Dermal Sensitization - MP
No
No
No
No
No
No
Yes
Yes
Yes
Yes
Yes
Yes
I/Composition: MP = Manufacturing-use product; there are EPA registered MP Products: EPA Reg. No. 476-1107 (25%), EPA
Reg. No. 476-1546 (90%) and EPA Reg. No. 476-2162 (90%).
2/ Data must be submitted no later than November, 1984 .
-------
TABLE C
PRODUCT SPECIFIC DATA REQUIREMENTS FOR END-USE PRODUCTS CONTAINING CHEMICAL CARBOPHENOTHION
Data Requirement
Composition
I/
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
§158.135 Toxicology
ACUTE TESTING
81-1 - Acute Oral Toxicity- Rat EP
81-2 - Acute Dermal Toxicity- EP
Rabbit
81-3 - Acute Inhalation Tox- EP
icity- Rat
No
No
No
Yes V
Yes V
Yes 3/
T7Composition:EP = End-Use Product~
2/ Data must be submitted no later than" November, 1984
-/ Registrants have the option of accepting the restrictecUuse classification, or submitting the data
-------
II. REQUIREMENT FOR SUBMISSION OF GENERIC DATA
A. This portion of the guidance document is a Notice
issued under the authority of FIFRA Section 3(c)(2)(B)
and describes, in table format, the data required
for maintaining the registrability of each product.
Additionally, a bibliography (Appendix II-l) is
included that identifies that data considered as •
part of the data base supporting this standard. EPA
has determined that additional generic data described
in this Notice must be submitted to EPA for evaluation
in order to maintain in effect the registration(s)
of your product(s) identified as an attachment to
the cover letter accompanying this guidance document.
As required by FIFRA Section 3(c)(2)(B), you are
required to take.appropriate steps to comply with
this Notice.
EPA may suspend the registration of each of those
products unless, within the specified time, you have
informed EPA how you will satisfy the requirements
of this Notice. Any such suspension will remain in
effect until you have complied with the terms of
this Notice.
B. What Generic Data V Must Be Submitted. You may
ascertain which generic data you must submit by
consulting Table A at the end of this chapter. That
table shows all the generic data needed to evaluate
the continued registrability of all products, and
the dates by which the data must be submitted. The
required data must be submitted and any necessary
studies must be conducted in accordance with EPA-
approved protocols, the Pesticide Registration Guide-
lines 2_l, or data collected under the approved proto-
cols of the Organization for Economic Cooperation
and Development (OECD). If you wish not to develop
data which are necessary to support the registration
or reregistration of certain uses appearing in your
labeling, you may delete those uses at the time you
submit your revised labeling.
I/ Generic data pertain to the properties or effects of a
particular ingredient, and thus are relevant to an evaluation of
the risks of all products containing that ingredient (or all such
products having a certain use pattern), regardless of any such
product's unique composition or use. Product-specific data relate
only to the properties or effects of a product with a particular
composition (or a group of products with closely similar composition)
"2j The Pesticide Registration Guidelines were reproposed on
November 24, 1982 in 47 Federal Register 53192.
22
-------
Also for certain kinds of testing (generally eco-
logical effects), EPA requires the test substance to
be a "typical formulation," and in those cases EPA
needs data of that type for each major formulation
category (e.g., emulsifiable concentrates, wettable
powders, granulars, etc.) These are classified as
generic data and when needed are specified in Table
A. EPA may possess data on certain "typical formu-
lations" but not others. Note; The "typical formu-
lation" data should not be confused with product-
specific data (Table B) which are required on each
formulation. Product-specific data are further
explained in Chapter IV of this document.
C. Options Available for Complying With Requirements to
Submit Data
Within 90 days of your receipt of this Notice you must
submit to EPA a completed copy of the form entitled
"FIFRA Section 3(c)(2)(B) Summary Sheet" [EPA Form
8580-1, Appendix II-2] for each of your products.
On that form you must state which of the following
methods you will use to comply with the requirements
of this Notice:
1. (a) Notify EPA that you will submit the data, and
(b) either submit the existing data you believe
will satisfy the requirement, or state that
you will generate the data by conducting
testing. If the test procedures you will
use deviate from (or are not specified in)
the Registration Guidelines or protocols
contained in the Reports of Expert Groups to
the Chemicals Group, Organization for Economic
Cooperation and Development (OECD) Chemicals
Testing Programme, you must enclose the
protocols you will use.
2. Notify EPA that you have entered into an agree-
ment with one or more other registrants to
jointly develop (or share in the cost of develop-
ing) the data. If you elect-this option, you
must notify EPA which registrant(s) are parties
to the agreement.
3. File with EPA a completed "Certification of
Attempt to Enter Into an Agreement With Other
Registrants for Development of Data" (EPA Form
8580-6, Appendix II-3)*/
jV FIFRA Section 3(c)(2)(B) authorizes joint development of
data by two or more registrants, and provides a mechanism by
which parties can obtain an arbitrator's decision if they agree
to jointly develop data but fail to agree on all the terms of
(Footnote continued at bottom of next page)
23
-------
4. Request that EPA amend your registration by deleting
the uses for which the data are needed. (This option
is not available to applicants for new products.)
5. Request voluntary cancellation of the registration(s)
of your products for which the data are needed.
(This option is not available to applicants for new
products.)
D. Procedures for Requesting Changes in Testing .
Methodology and Extensions of Time
EPA recognizes that you may disagree with our con-
clusions regarding the appropriate ways to develop
the required data or how quickly the data must be
submitted. If the test procedures you plan to use
deviate from (or are not specified in) the regis-
tration guidelines or protocols contained in the
reports of the Expert Groups to the Chemical Groups,
Organization for Economic Cooperation and Development
(OECD) Chemicals Testing Programme, you must submit
the protocol for Agency review prior to the initiation
of the test.
If you think that you will need more time to generate the
required data than is allowed by EPA's schedule, you may
(Footnote continued from previous page)
the agreement. The statute does not compel any registrant to
agree to develop data jointly.
In EPA's opinion, joint data development by all registrants
who are subject to the requirements to submit a pertinent item
of data or a cost-sharing agreement among all such registrants
is clearly in the public interest. Duplication of testing could
increase costs, tie up testing facilities, and subject an unneces-
sarily large number of animals to testing.
As noted earlier, EPA has discretion not to suspend the
registration of a product when a registrant fails to submit data
required under FIFRA Section 3(c)(2)(B). EPA has concluded that
it is appropriate to exercise its discretion not to suspend in
Ways which will discourage duplicative testing. Accordingly, if
(1) a.registrant has informed us of his intent.to develop and
submit data required by this Notice; and (2) a second regis-
trant informs EPA that it has made a bona fide offer to the
first registrant to share in the expenses of the testing [on
terms to be agreed upon or determined by arbitration under FIFRA
Section 3(c)(2)(B)(iii)]; and (3) the first registrant has declined
to agree to enter into a cost-sharing agreement, EPA will not
suspend the second firm's registration. While the first firm is
not required to agree to jointly develop data, EPA is not required
to force the second firm to engage in economically inefficient
duplicative testing in order to maintain its registration.
24
-------
submit a request for an extension of time. The ex-
tension request must be submitted in writing to the
Product Manager. The extension request should state
the reasons why you conclude that an extension is
appropriate. While EPA considers your request, you
must strive to meet the deadline for submitting the
required data.
III. REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA
Note: This Section applies only to manufacturing-use
products, not end-use products.
A necessary first step in determining which statements
must appear on your product's label is the completion
and submission to EPA of product-specific data* listed
on the form entitled "Product Specific Data Report"
(EPA Form 8580-4, Appendix III-l) to fill "gaps" iden-
tified by EPA concerning your product. Under the
authority of FIFRA Section 3(c)(2)(B), EPA has determined
that you must submit these data to EPA in order to
register or reregister your product(s). All of these
data must be submitted not later than six months after
you receive this guidance document.
"Product-Specific Data Requirements for Manufacturing-
Use Products" appearing in Table B permit you to deter-
mine which product-specific data you must submit.
This can be done by examining the entries in the column
of those tables entitled "Must Data Be Submitted Under
§3(c)(2)(B)."
_*_/ Product specific data pertains to data that support the
formuTation which is marketed; it usually includes product chemistry
data and acute toxicology data.
25
-------
IV. SUBMISSION OF REVISED LABELING AND PACKAGING INFORMATION
Note: This section applies to end-use products only to
the the extent described under Section II of this document,
Otherwise, the following information pertains exclusively
to manufacturing-use products.
The Agency requires applicants for registration or re-
registration to ensure that each label (1) contains
accurate, complete, and sufficient instructions and
precautions, reflecting the results of data concerning
the product and its ingredients, and (2) incorporates
labeling format and terminology which are sufficiently
standardized to avoid user confusion.
As part of your application, you will be required to
submit draft labeling consistent with: applicable
product-specific data; the precautionary statements and
use directions; and the regulations concerning class-
ification [40 CFR §162.11(c)], packaging [40 CFR §162.16],
and labeling [40 CFR §162.10, Appendix IV-1 an IV-2],
as indicated by the following paragraphs of this chapter
of the guidance document.
If owners of currently registered products fail to submit
revised labeling and packaging information complying with
this Section and/or Section II, EPA may issue a notice
of intent to cancel the registration under FIFRA §6(b)(l).
A. Label Contents
40 CFR §162.10 (Appendix IV-1) requires that certain
specific labeling statements must appear at certain
locations on the label. This is referred to as format
labeling. Specific label items listed below are keyed
to Tables D, E, and F (Appendix IV-2).
Item 1. PRODUCT NAME - The name, brand, or trademark
is required to be located on the front panel, pre-
ferably centered in the upper part of the panel. The
name of a product will not be accepted if it is false
or misleading. See Appendix IV-1. [40 CFR §162.10(b)]
Item 2. COMPANY NAME AND ADDRESS - The name and.
address of the registrant or distributor is required
on the label. The name and address should preferably
be located at the bottom of the front panel or at
the end of the label text. See Appendix IV-1. [40
CFR §162.10(c)]
Item 3. NET CONTENTS - A net content statement is
required on all labels. The preferred location is
the bottom of the front panel immediately above the
26
-------
company name and address, or at the end of the label
text. The net contents must be stated in terms of
weight, expressed as avoirdupois pounds and ounces,
and stated in.terms of the largest suitable unit,
i.e., "1 pound 10 ounces" rather than "26 ounces."
In addition to the required units specified, net
contents may be expressed in metric units. See
Appendix IV-1. [40 CFR §162.10(d)]
Item 4. EPA REGISTRATION NUMBER - The registration
number assigned to the pesticide product must appear
on the label, preceded by the phrase "EPA Registration
No.," or "EPA Reg. No." The registration number
must be set in type of a size and style similar to
other print on that part of the label on which it
appears and must run parallel to it. The registration
number and the required identifying phrase must not
appear in such a manner as to suggest or imply re-
commendation or endorsement of the product by the
Agency. See Appendix IV-1. [40 CFR §162.10(e)]
Item 5. EPA ESTABLISHMENT NUMBER - The EPA estab-
lishment number, preceded by the phrase "EPA Est."
is the final establishment at which the product
was produced, and may appear in any suitable location
on the label or immediate container. It must also
appear on the wrapper or outside container of the
package if the EPA establishment registration number
on the immediate container cannot be clearly read
through such wrapper or container. See Appendix IV-1.
[40 CFR §162.10(f)]
Item 6. INGREDIENT STATEMENT - An ingredient state-
ment is required on the front panel and must contain
the name and percentage by weight of each active
ingredient and the total percentage by weight of
all inert ingredients. The preferred location is
immediately below the product name. The ingredient
statement must run parallel with, and be clearly
distinguished from, other text on the panel. It
must not be placed in the body of other text. See
Appendix IV-1. [40 CFR 162.10(g)]
Item 6A. POUNDS PER GALLON STATEMENT - For liquid
agricultural formulations, the pounds per gallon of
active ingredient must be indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS - All
labels are required to have precautionary statements
grouped together on the front panel, preferably
within a block outline. The table below shows the
27
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minimum type size requirements on various size labels,
as set forth in the Regulations.
Size of Label Signal Word as Re- "Keep Out of Reach
on Front Panel quired Minimum Type of Children"
in Square Inches Size All Capitals as Required
5 and under 6 point 6 point
above 5 to 10 10 point 6 point
above 10 to 15 12 point 8 point
above 15 to 30 14 point 10 point
over 30 18 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT - All labels
are required to have the statement "Keep Out of
Reach of Children" located on the front panel above
the signal word except where contact with children
during distribution or use is unlikely. See Appendix
IV-1. [40 CFR §162.10(h)(l)(ii)]
Item 7B. SIGNAL WORD - The signal word (Caution,
Warning, or Danger) is required on the front panel
immediately below the child hazard warning statement.
See Appendix IV-1. [40 CFR §162.10 (h)(l)(i)]
Item 1C. SKULL & CROSSBONES AND WORD "POISON" - On
products assigned a toxicity Category I on the
basis of oral, inhalation, or dermal toxicity, the
word "Poison" shall appear on the label in red on a
background of distinctly contrasting color and the
skull and crossbones shall appear in immediate
proximity to the word poison. See Appendix IV-1.
[40 CFR §162.10(h)(1)(i)]
Item 7D. STATEMENT OF PRACTICAL TREATMENT - A state-
ment of practical treatment (first aid or other)
shall appear on the label of pesticide products in
toxicity Categories I, II, and III. See Appendix
IV-1. [40 CFR §162.10(h)(l)(iii)]
Item 7E. REFERRAL STATEMENT - The statement "See
Side (or Back) Panel for Additional Precautionary
Statements" is required on the front panel for all
.products, unless all required precautionary statements
apoear on the front panel. See Appendix IV-1. [40
CFR §162.10(h)(1)(iii)]
Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING -
The precautionary statements as listed below must
appear together on the label under the heading
"PRECAUTIONARY STATEMENTS." The preferred location
is at the top of the side or back panel preceding
the directions for use, and it is preferred that
28
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these statements be surrounded by a block outline.
Each of the three hazard warning statements must be
headed by the appropriate hazard title. See Appendix
IV-1. [40 CFR §162.10 (h)(2)]
Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS -
Where a hazard exists to humans or domestic animals,
precautionary statements are required indicating
the particular hazard, the route(s) of exposure and
the precautions taken to avoid accident, injury or
damage. See Appendix IV-1. [40 CFR §162.10 (h)(2)(i)]
Item 8B. ENVIRONMENTAL HAZARD - Where a hazard exists
to non-target organisms excluding humans and domestic
animals, precautionary statements are required
stating the nature of the hazard and the appropriate
precautions to avoid potential accident, injury, or
damage. See Appendix IV-1. [40 CFR §162.10(h)(2)(ii)]
Item 8C. PHYSICAL OR CHEMICAL HAZARD
1. Flammability statement. Precautionary statements
relating to flammability of a product are required
to appear on the label if it meets the criteria in
Appendix IV-3. The requirement is based on the re-
sults of the flashpoint determinations and
flame extension tests required to be submitted
for all products. These statements are to be
located in the side/back panel precautionary
statements section, preceded by the heading
"Physical/Chemical Hazards." Note that no
signal word is used in conjunction with the flam-
mability statements.
2. Criteria for declaration of non-flammability.
The following criteria will be used to determine
if a product is non-flammable:
a. A "non-flammable gas" is a gas (or mixture
of gases) that will not ignite when a lighted
match is placed against the open cylinder
valve.
b. A "non-flammable liquid" is one having a
flashpoint greater than 350°F (177°C) as
determined by the method specified in 40 CFR
§163.61-8(c)(13) (ii) of Subpart D.
c. A "non-flammable aerosol" is one which meets
the following criteria:
i. The flame extension is zero inches, using the
method specified in 40 CFR §163.61-8(c)(13)(ii);
29
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ii. There is no flash back; and
iii. The flashpoint of the non-volatile liquid
component is greater than 350°F (177°C),
determined by the method specified in 40 CFR
§163.61-8(c)(13)(i).
3. Declaration of non-flammability. Products which
meet the criteria for non-flammability specified
above may bear the notation "non-flammable" or
"nonflammable (gas, liquid, etc.)" on the label.
It may appear as a substatement to the ingredients
statement, or on a back or side panel, but shall
not be highlighted or emphasized (as with an
inordinately large type size) in any way that
may detract from precaution.
4. Other physical/chemical hazard statements. When
chemistry data submitted in accordance with 40 CFR
§163.61-10(c) demonstrate hazards of a physical or
chemical nature other than flammability, appropriate
statements of hazard will be prescribed. Such
statements may address hazards of explosivity,
oxidizing or reducing capability, or mixing with
other substances to produce toxic fumes.
Item 9. PRODUCT CLASSIFICATION: CLASSIFICATION
LABELING REQUIREMENTS AND COMPLIANCE SCHEDULE -
Section 3(d) of FIFRA requires that all pesticide
formulations/uses be classified for either general
or restricted use, and that those uses classified
as restricted be limited to use by certified appli-
cators or persons under their direct supervision
(or subject to such other restrictions as may be
imposed by regulation).
In the Registration Standard, the Agency has: (1)
indicated certain formulations/uses to be restricted,
based either on a previous classification determination
made through the optional procedures of 40 CFR
§162.30 or based on data already available to the
Agency, or (2) indicated certain formulations/
uses to be unrestricted, based on data already
available to the Agency, or (3) reserved any classi-
fication decision until appropriate short-term data
are submitted. Uses have not been classified for
general use at this time because such a decision
requires an evaluation of chronic data, most of which
has yet to be generated.
30
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The product-specific data required by the Standard
should be used by each registrant to make a classi-
fication determination following the criteria of
40 CFR §162.11(c) (Appendix V-4). The draft label(s)
submitted to the Agency as part of your application
should reflect this determination, and must be
consistent with the terms of 40 CFR §162.10 and
this guidance package with respect to label language
and format for restricted use products. (No label
changes with respect to classification are required
for products with unrestricted uses.) The rationale
supporting a classification proposal by the registrant
that differs from a classification determination
found in the Standard should be submitted with your
application.
During the Agency's review of your application, your
proposed classification determination will be evaluated
in accordance with the provisions of 162.11(c). You
will be notified of the Agency's classification
evaluation.
A. Classification Labeling Requirements
1. Unrestricted Uses - No label changes with
respect to a classification statement are
necessary for those formulations/uses that
are unrestricted.
2. Restricted Uses - Pesticide products bearing
directions for use for formulations/uses
classified restricted shall bear statements
of restricted use classification on the
front panel as described below:
a. Front panel statement of restricted use
classification.
i. At the top of the front panel of the
label, set in type of the same
minimum sizes as required for human
hazard signal words (see table in
40 CFR §162.10(h)(1)(iv)), and appear-
ing with sufficient prominence
relative to other text and graphic
material on the.front panel to make
it unlikely to be overlooked under
customary conditions of purchase and
use, the statement "Restricted Use
Pesticide" shall appear.
31
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ii. Directly below this statement on the
front panel, a summary statement of
the terms of restriction shall
appear. If use is restricted to
certified applicators, the following
statement is required: "For retail
sale to and use only by Certified
Applicators or persons under their
direct supervision and only for those
uses covered by the Certified
Applicator's certification." If,
however, other regulatory restrictions
are imposed, the Administrator will
define the appropriate wording for the
terms of restriction by regulation.
3. Some But Not All Uses Restricted - If you determine
that some uses should be classified RESTRICTED
and some uses should be unrestricted, several
courses of action detailed below are available:
i. You may delete all RESTRICTED uses and submit
a draft label of the registration of your
product to reflect only those uses that are
unrestricted.
ii. Unrestricted uses may appear on a RESTRICTED
label, but not vice versa. Therefore you
have the option of using a RESTRICTED USE
label bearing all of your directions for use.
If you choose this option, you may not
distinguish those uses that are not unrestricted
from those that are RESTRICTED.
iii. You may register two separate products with
identical formulations, one containing only
unrestricted uses and the other RESTRICTED
uses. To do so, submit two applications for
reregistration, each containing all forms
and necessary labels. Both applications
should be submitted simultaneously. Note
that the product names will be assigned
separate registration numbers.
B. Compliance Schedules
1. Unclassified uses - None.
2. Restricted uses - The compliance schedule for
restricted use products is as follows:
32
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No product with a use classified for restricted use
under this standard may be released for shipment by
the registrant or producer after one year from the
date of issuance of this standard, unless such
product bears the restricted-use classification. All
products still in channels of trade after two years
from the date of issuance of this standard must be
labeled for restricted-use.
Item 11A. STORAGE AND DISPOSAL BLOCK - All labels
are required to bear storage and disposal statements.
These statements are developed for specific containers,
sizes, and chemical content. Make certain that the
statement you use pertains specifically to your
product. These instructions must be grouped and
appear under the heading "Storage and Disposal" in
the directions for use. This heading must be set
in the same type sizes as required for the child
hazard warning. Refer to Appendix IV-5 for the
latest specific storage and disposal product label
statements.
Item 11B. DIRECTIONS FOR USE - Directions for use
must be stated in terms which can be easily read
and understood by the average person likely to use
or to supervise the use of the pesticide. When
followed, directions must be adequate to protect
the public from fraud and from personal injury and
to prevent unreasonable adverse effects on the
environment. See Appendix IV-1. [40 CFR §162.10]
B. Collateral Information
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, and other graphic printed matter which is referred
to on the label or which is to accompany the product are
termed collateral labeling. Such labeling may not bear
claims or representations that differ in substance from
those accepted in connection with registration of the
product. It should be made part of the response to this
notice and submitted for review.
V. INSTRUCTIONS FOR SUBMISSION
All applications prepared in response to this Notice should
be addressed as follows:
Product Manager William H. Miller
Phone No. (703) 557-2600
Registration Division (TS-767)
Office of Pesticide Programs
Environmental Protection Agency
Washington, D.C 20460
33
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For each product for which continued registration is desired:
1. Within 90 days from receipt of this document, you must
submit the "FIFRA Section 3(c)(2)(B) Summary Sheet" EPA
Form 8580-1. Refer to Appendix II-2 with appropriate
attachments.
2. Within 6 months from receipt of this document registrants
must submit:
a. Confidential Statement of Formula, EPA Form 8570-4.
b. Product Specific Data Report, EPA Form 8580-4 (Appendix
III-l).
c. Two copies of any required product-specific data.
d. Two copies of draft labeling, including the label and
associated brochures. If current labeling conforms
to the requirements of this guidance document and the
results of the short-term data, the registrant may
submit such labeling. (End-use product labeling
needs to comply specifically with the instruction in
Section II of this guidance document.) The labeling
should be either typewritten text on 8-1/2 x 11 inch
paper or a mockup of the labeling suitable for
stortage in 8-1/2 x 11 inch files. The draft label
must indicate the intended colors of the final label,
clear indication of the front panel label, and the
intended type sizes of the text.
3. Within the time set forth in Table A, all generic data
must be submitted by the affected registrant(s).
Note; If for any reason any required test is delayed or aborted
so that meeting the agreed submission time will be delayed,
notify the Product Manager listed above.
After the Supreme Court has ruled on the Monsanto Decision,
you will be informed as to when you must submit your Application
for Amended Pesticide Registration (EPA Form 8570-1) and the
associated data support information.
34
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Appendix "II-l
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
00002875 Frear, D.E.H.; Boyd, J.E. (1967) Use of Daphnia magna for the
microbioassay of pesticides: I. Development of standardized
techniques for rearing Daphnia and preparation of dosage-mor-
tality curves for pesticides. Journal of.Economic Entomology.
60(5):1228-1236. (Also In unpublished submission received
May 11, 1977 under 239-2458; submitted by Chevron Chemical Co.,
Richmond, Calif.; CDL:230225-A)
00036074 Johnston, C.D.; Scott, W.J. (1966) Trithion: Three-Generation Re-
production Study in the Rat. (Unpublished study received Sep 4,
1974 under 4E1418; prepared by Woodard Research Corp., submitted
by Stauffer Chemical Co., Richmond, Calif.; CDL:095359-C)
00036935 Atkins, E.L.; Greywood, E.A.; Macdonald, R.L. (1975) Toxicity of
Pesticides and Other Agricultural Chemicals to Honey Bees: Labo-
ratory Studies. By. University of California, Dept. of Entomolo-
gy. ?: UC, Cooperative Extension. (Leaflet 2287; published
study.)
00060628 Johansen, C.A.; Eves, J. (1965) Bee Poisoning Investigations, 1965:
Report No. G-1705; Report No. 17338. (Unpublished study, in-
cluding letter dated Jun 12, 1973 from C.A. Johansen to A.D. Co-
hick, received Mar 27, 1974 under 4F1485; prepared by Washington
State Univ., Dept. of Entomology, submitted by Chemagro Corp.,
Kansas City, Mo.; CDL:092011-I)
00066341 U.S. Environmental Protection Agency, Environmental Research Labo-
ratory (1981) Acephate, Aldicarb, Carbophenothion, DEF, EPN,
Ethoprop, Methyl Parathion, and Phorate: Their Acute and Chronic
Toxicity, Bioconcentration Potential, and Persistence as Related
to Marine Environments: EPA-600/4-81-023. (Unpublished study)
00089847 Elsea, J.R. (1956) Acute Oral Administration—Rats: Supplement to
Report Dated April 30, 1956. (Unpublished study received Dec
30, 1960 under PP0334; prepared by Hazleton Laboratories, sub-
mitted by Stauffer Chemical Co., New York, N.Y.; CDL:090362-D)
00089852 Weir, R.J., Jr. (1956) Final Report: Subacute Administration—Dogs.
(Unpublished study received Dec 30, 1960 under PP0334; prepared
by Hazleton Laboratories, submitted by Stauffer Chemical Co.,
New York, N.Y.; CDL:090362-J)
00093046 Bellies, R.P.; Knott, W.'; Wright, L. (1966) Trithion Safety Eval-
uation on Fish and Wildlife (Bobwhite Quail, Rainbow Trout, and
Sunfish). (Unpublished study, received Mar 18, 1966 under 476-
1087; prepared by Woodard Research Corp., submitted by Stauffer
Chemical Co., Richmond, Calif.; CDL:003715-A)
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
00093054 Fogleman, R.W. (1956) Subacute Feeding-Rats. (Unpublished study
received Aug 20, 1956 under PP0084; prepared by Hazleton Labo-
ratories, submitted by Stauffer Chemical Co., Chauncey, N.Y.;
CDL:090115-E)
00093076 Johnston, C.D. (1967) Trithion: Safety Evaluation by Two-year
Feeding Studies in the Rat and the Dog. (Unpublished study
received Jan 13, 1967 under 1F1108; prepared by Woodard Research
Corp., submitted by Stauffer Chemical Co., Richmond, Calif.;
CDL:090876-B)
00093111 Hoffman, L.J.; DeBaun, J.R.; Ross, J.H.; et al. (19??) Metabolism
of S-4-chloro (U-14C) phenyl thionethyl-O,0-diethylphos-
phorodithioate (Trithion-14C) in the Rat. (Unpublished study
received on unknown date under 4E1418; prepared by Stauffer
Chemical Co., submitted by Interregional Research Project No. 4,
New Brunswick, N.J.; CDL:098174-A)
00093133 McCann, J.A. (1972) Greenlight Trithion for Lawn Cinch Bug Con-
trol: Rainbow Trout (Salmo gairdneri): Test No. 485. (U.S.
Agricultural Research Service, Pesticides Regulation Div.,
Animal Biology Laboratory; unpublished study; CDL:129705-A)
05000837 Johansen, C.A. (1972) Toxicity of field-weathered insecticide
residues to four kinds of bees. Environmental Entomology
l(3):393-394.
05001991 Stevenson, J.H. (1978) The acute toxicity of unformulated
pesticides to worker honey bees (Apis melliferaL). Plant
Pathology 27(1):38-40.
05008989 Johansen, C.; Eves, J. (1967) Toxicity of Insecticides to the
Alkali Bee and the Alfalfa. Leafcutting Bee. Pullman, Wash.:
Washington State University Agricultural Research Station.
(Washington Agricultural Research Station circular no. 475)
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GS0108001 McBain, J.B., et aJL (1977). Metabolism of [14C]phenyl carbopheno-
thion by orange trees. Unpublished study provided [to FAQ/WHO]
by Stauffer Chemical Co., Mountain View Research Center, Mountain
View, CA 94902 MRC-B-69. [Information pertaining to this study
was derived fron the FAO/VJHO, 1980 Monograph Addendum p. 79-88.]
GS0108002 I.R. Project, (1974). Trithion residue analysis log Nos.
A-0132, A-0133, and A-0134. (Unpublished study received
October 4, 1973 under PP#4E1434; CDL:RCB 112371.)
GS0108003 Stauffer Chemical Co. (1972). Trithion residue analysis log
FSDS No. A-1468. (Unpublished study received January 13, 1972
under PP#2H5006; CDL:RCB Unavailable.)
GS0108004 Coffin, D.E. (1964). Oxidative metabolism and persistence of
Trithion on field-sprayed lettuce. J.A.O.A.C. 47:662-667.
GS0108005 Stauffer Chemical Co. (1961). Determination of Trithion residues on
alfalfa. (Unpublished study received January 1, 1961 under
PP#0334; CDL:PCB 114020.)
GS0108006 Hoffman, L.J., eta],. (19??). Metabolism of S-[4-chloro(U-14C)
phenyl thionethyl]-O-0-diethylphosphorodithioate (Trithion-14C)
in the rat. Submitted by Stauffer Chemical Co. under
PP#4E1418(118321).
GS0108007 Menn, J.J., De Baun, and J.B. McBain. (1976). Recent advances
in the metabolism of organophosphorus insecticides. Fed. Proc.
35:2598-2602.
GS0108008 Association of Official Analytical Chemists. (1975). Methods of
Analysis. 12th Edition. Sections 29.033-.037 and 29.038-.043.
GS0108009 FDA Pesticides Analytical Manual. Volume I - Organophosphates.
GS0108010 FDA Pesticides Analytical Manual. Volume II. Pesticide Reg.
Sec. 180.156: carbophenothion.
GS0108011 U.S.' EPA. (1963). Memorandum of J. Alpert, dated June 13,
1963 pertaining to method trial for Trithion residues in animal
tissue. PP#0366(114151).
GS0108012 U.S. EPA. (1962). Memorandum of G.J. Beusch, dated November
8, 1962. Carbophenothion on various feed crops. Evaluation
of analytical method and residue data. PP#0334(114024).
GS0108013 U.S. EPA. (1963). Memorandum of J.L. Burnett, dated April
22, 1963 pertaining to Trithion in beef fat. PP#0366(114148).
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GS0108014 U.S. EPA. (1962). Memorandum of J.A. Gaul, dated September
27, 1962 pertaining to PP#0334 Trithion on forage crops.
PP#0334(114019).
GS0108015 U.S. EPA. (1963). Memorandum of J.A. Gaul dated April 12,
1963 pertaining to Trithion in beef fat. PP#0366(114148).
GS0108016 U.S. EPA. (1971). Memorandum of E.L. Gunderson, dated July
22, 1971. Method tryout for carbophenothion (Trithion) on
soybeans. PP#1F1108(117186).
GS0108017 Patchett, G.G. and G.H. Batchelder. (1960). Determination of
Trithion crop residues by cholinesterase inhibition measurement.
J. Agric. Food Chem. 8(l):54-57.
GS0108018 Stauffer Chemical Co. (1956). Colorimetric method for the
determination in plant materials. (Unpublished study received
June 1, 1956 under PP#0084; CDLrRCB 113227.)
GS0108019 Stauffer Chemical Co. (1956). Colorimetric determination
in plant materials (as revised May 15, 1956). (Unpublished
study received June 1, 1956 under PP#0159; CDLrRCB 113227.)
GS0108020 Stauffer Chemical Co. (1957). Analysis of milk of cattle fed
Trithion. (Unpublished study received December 1, 1957 under
PP #0159; CDLrRCB 113405.)
GS0108021 Stauffer Chemical Co. (1959). Determination of Trithion crop
residues by cholinesterase inhibition. (Unpublished study received
March 1, 1957 under PPI0120; CDLrRCB 113303.)
GS0108022 Stauffer Chemical Co. (1960). Alternate procedures useful in
the determination of Trithion crop residues by cholinesterase
inhibition measurement. (Unpublished study received January 1,
1961 under PP #0334; CDLrRCB 114020.)
GS0108023 Stauffer Chemical Co. (1962). Determination of Trithion residues
in alfalfa. (Unpublished study received unknown date under
PP #0334; CDLrRCB114019.)
GS0108024 Stauffer Chemical Co. (1962). Carbophenothion residue identification
in cattle fat tissues. (Unpublished study received unknown
date under PP #0366; CDLrRCT 114149.)
GS0108025 Stauffer Chemical Co. (1962). Trithion residue identification
in cattle fat tissues. (Unpublished study received August 22,
1962 under PP #0366; CDLrRCB 114151.)
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GS0108026
GS0108027
GS0108028
GS0108029
GS0108030
GS0108031
GS0108032
GS0108033
GS0108034
GS0108035
Stauffer Chemical Co. (1963). Determination of carbophenothion,
Trithion residues in cow fat by the cholinesterase method.
(Unpublished study received unknown date under PP #0366; CDLrRCB
114150.)
Stauffer Chemical Co. (1968). Method #RR68-34: Determination
of Trithion and five oxidation products in or on fresh tea,
dried tea, brewed tea, and spent tea by gas chromatography.
(Unpublished study received January 13, 1972 under PP #2H50006;
CDLrRCB not available.)
Stauffer Chemical Co. (1970). Method #WRC-70-77: Determination
of residues of Trithion® and its oxygen analogs. (Unpublished study
received January 27, 1971 under PP #1F1108; CDLrRCB 117184.)
Stauffer Chemical Co. (1971).
®
Method #WRC 70-77Rlr
Determination
of residues of Trithion and its oxygen analogs. (Unpublished study
received January 13, 1972 under PP #2H5006; CDLrRCB not available.)
Stauffer Chemical Co. (1973). Method #WR 73-9: Determination
of residues of carbophenothion and its oxygen analogs in milk
and cream. (Unpublished "study received February 14, 1973 under
PP #4E1418; CDLrRCB 112320.)
Stauffer Chemical Co. (1971). Inter-office correspondence frcm
J.C. McKay to R.L. Riggs dated November 29, 1971 (Unpublished study
received January 13, 1972 under PP #2H5006; CDLrRCB not available.)
Stauffer Chemical Co. (1973). Inter-office correspondence from
J.C. McKay to R.L. Riggs dated March 1, 1973 (Unpublished study
received January 13, 1972 under PP #2H5006; CDLrRCB not available.)
Stauffer Chemical Co. (1957). Data entitledr "Table beets-
Trithion residue studies." (Unpublished study received
December 1, 1957 under PP #0159; CDLrRCB 113405.)
Stauffer Chemical Co. (1957). Data table entitledr ."Sugar
beets-Trithion residue studies." (Unpublished study received
December 1, 1957 under PP #0159; CDLrRCB 113405.)
Stauffer Chemical Co. (1957). Data table entitledr "Table
beets-Trithion residue studies." (Unpublished study receive
December 1, 1957 under PP #0159; CDLrRCB 113405.)
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GS0108036 Stauffer Chemical Co. (1957). Data table entitled: "Sugar beets-
Trithion residues studies." (Unpublished study received
December 1, 1957 under PP #0159; CDL:RCB 113405.)
GS0108037 Stauffer Chemical Co. (1959). Trithion Residue Studies.
(Unpublished study received Unknown date under PP #0120;
CDL:RCB 113545.)
GS0108038 Stauffer Chemical Co. (1956). Data table entitled "Trithion
residues on beans (shelled)-1956." (Unpublished study received
March 1, 1957 under PP #0120; CDL:RCB 11303.)
GS0108039 Stauffer Chemical Co. (1971). Report Nos. A-120, A-121, A-122,
328, 338, 378, 2436, and 2468 in Section D. (Unpublished study
received January 27, 1971 under PP #1F1108;CDL:RCB 117124.)
GS0108040 Stauffer Chemical Co. (1957). Data table entitled: "Lima beans-
Trithion residue studies." (Unpublished study received
received December 1, 1957 under PP #0159; CDL:RBC 113405.)
GS0108041 Stauffer Chemical Co. (1957). Data table entitled "Peas-Trithion
residue studies." (Unpublished study received December 1, 1957
under PP #0159; CDL:RCB 113405.)
GS0108042 Stauffer Chemical Co. (1957). Data table entitled "Green beans-
Trithion residue studies." (Unpublished study received
December 1, 1957 under PP #0159; CDL:RCB 113405.)
GS0108043 Stauffer Chemical Co. (1957). Data table entitled "Peas-Trithion
residue studies." (Unpublished study received December 1, 1957
under PP #0159; CDL:RCB 113405.)
GS0108044 Stauffer Chemical Co. (1961). Data table entitled "Trithion
residue studies-Bean straw." (Unpublished study received
January 1, 1961 under PP #0334; CDL:RCB 114020.)
GS0108045 Stauffer Chemical Co. (1957)." Eggplant-Trithion Residue Studies.
(Unpublished study received December 1, 1957 under PP #0159;
CDL:RCB 113405.)
GS0108046 Stauffer Chemical Co. (1957). Peppers-Trithion Residue Studies.
(Unpublished study received December 1, 1957 under PP #0159;
CDL:RBC 113405.)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GS0108047 Stauffer Chemical Co. (1957.) Tomatoes-Trithion Residue Studies.
(Unpublished study received December 1, 1957 under PP #0159;
CDLtRBC 113405.)
GS0108048 Stauffer Chemical Co. (1959.) Trithion residue studies-cucumbers.
(Unpublished study received Unknown date under PP #0201;CDL:RCB
113545.)
GS0108049 Stauffer Chemical Co. (1959.) Watermelon-Trithion residue studies.
(Unpublished study received December 1, 1957 under PP#0159; CDL:RCB
113405.)
GS0108050 Stauffer Chemical Co. (1957.) Trithion residues in or on oranges,
citrus citron, grapefruit, kumquats, lemons, limes, tangelos,
and tangerines. Tables B and D. (Unpublished study received
December 1, 1957 under PP #0159; CDL:RCB 113405.)
GS0108051 Stauffer Chemical Co. (1957.) Trithion residues in or on
oranges, citrus citron, grapefruit, kumquats, lemons, limes,
tangelos, and tangerines. Table F. (Unpublished study received
December 1, 1957 under PP #0159; CDLzRCB 113405.)
GS0108052 Stauffer Chemical Co. (1957.) Section D. Trithion residues in
or on oranges, citrus citron, grapefruit, kumquats, lemons,
limes, tangelos, and tangerines. Table H. (Unpublished study
received December 1, 1957 under PP #0159; CDL:RCB 113405.)
GS0108053 Stauffer Chemical Co. (1957.) Section D. Trithion residues in or
on oranges, citrus citron, grapefruit, kumquats, lemons, limes,
tangelos, and tangerines. Tables A, C, and E. (Unpublished
study received December 1, 1957 under PP #0159; CDLrRCB 113405.)
GS0108054 Stauffer Chemical Co. (1957.) Section D. Trithion residues in or
on oranges, citrus citron, grapefruit, kumquats, lemons, limes,
tangelos, and tangerines. Table G. (Unpublished study received
December 1, 1957 under PP #0159; CDL:RCB 113405.)
GS0108055 Stauffer Chemical Co. (1957.) Tables K-S in Section D. (Unpublished
study received March 1, 1957 under PP #0120; CDLrRCB 113303.)
GS0108056 Stauffer Chemical Co. (1957.) Table T in Section D. (Unpublished
study received March 1, 1957 under PP #0120; CDL:RCB 113303.)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GS0108057 Stauffer Chemical Co. (1957). Apricots-Trithion residue studies.
(Unpublished study received December 1, 1957 under PP #0159?
CDLrRCB 113405.)
GS0108058 Stauffer Chemical Co. (1957). Nectarines-Trithion residue studies.
(Unpublished study received December 1, 1957 under PP #0159;
CDLrRCB 113405.)
GS0108059 Stauffer Chemical Co. (1957). Peaches-Trithion residue studies.
(Unpublished study received December 1, 1957 under PP #0159;
CDL:RCB 113405.)
GS0108060 Stauffer Chemical Co. (1957). Cherries, Plums, and Prunes.
(Unpublished study received December 1, 1957 under PP #0159;
CDL:RCB 113405.)
GS0108061 IR-4 Project. (1973). Section D. FSDS Nos. A-0132-3, B-0553-8,
A-6004-T, B-0848, and A-5981. (Unpublished study received
October 4, 1973 under PP #4E1434; CDLrRCB 112371.)
GS0108062 IR-4 Project. (1973). FSDS Nos. A-8372. (Unpublished study received
September 4, 1974 under PP #4E1412; CDLrRCB 118319.)
GS0108063 Stauffer Chemical Co. (1957). Table I: Chronatographic analysis
of residues. (Unpublished study received March 1, 1957 under
PP #0120; CDLrRCB 113303.)
GS0108064 Stauffer Chemical Co. (1957). Data table entitled "Strawberries-
Trithion residue studies." (Unpublished study received December
1, 1957 under PP #0159; CDLrRCB 113405.)
GS0108065 Stauffer Chemical Co. (1957). Section D. Trithion Residues on
Almonds (Meats)-1956. (Unpublished study received March 1,
1957 under PP # 0120; CDLrRCB 113303.)
GS0108066 Stauffer Chemical Co. (1957). Almonds-Hulls and Kernels-Trithion
Residues Studies. (Unpublished study received December 1, 1957
under PP #0159; CDLrRCB 113405.)
GS0108067 Stauffer Chemical Co. (1961). Trithion Residues Studies-Almonds
-Hulls and Trithion Residue Studies-Almonds-Meats. Section D.
(Unpublished study received January 1, 1961 under PP #0334;
CDLrRCB 114020.)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GS0108068 Stauffer Chemical Co. (1971). Crop Residue Reports dated 9/30/70:
B-0208 and B-0188; 10/22/70: B-0195 and B-0147; and 11/2/70: B-
1023. (Unpublished study received January 27, 1971 under
PP #1F1108; CDL:RCB unknown.)
GS0108069 Stauffer Chemical Co. (1957). Trithion Residues on Walnuts
(Meats)-1956. (Unpublished study received March 1, 1957 under
PP #0120; CDL:RCB 113303.)
GS0108070 Stauffer Chemical Co. (1971). Crop Residue Report Nos. B-1061
(dated 10/5/70), B-1062 (dated 10/5/70), B-1063 (dated 10/22/70),
B-1064 (dated 9/30/70), and B-1065 (dated 10/22/70) (Unpublished
study received January 27, 1971 under PP #0334;CDL:RCB unknown.)
GS0108071 Stauffer Chemical Co. (1961). Trithion Residue Studies-Field
Corn. (Unpublished study received January 1, 1961 under
PP #0334; CDL:RCB 114020.)
GS0108072 Stauffer Chemical Co. (1961). Trithion Residue Studies-Sorghum.
(Unpublished study received January 1, 1961 under PP #0334;
CDL:RCB 114020.)
GS0108073 Stauffer Chemical Co. (1961). Determination of Trithion
residues on alfalfa after spraying at 8 oz. per acre. Report
to Stauffer Chemical Co., (Unpublished study received January
1, 1976 under PP #0334; CDL:RCB 114020.)
GS0108074 Stauffer Chemical Co. (1961). Trithion residue studies-forage
crops. (Unpublished study received January 1, 1961 under
PP #0334; CDL:RCB 114020.)
GS0108075 Stauffer Chemical Co. (1961). Trithion residue studies-Clover.
(Unpublished study received January 1, 1961 under PP #0334;
CDL:RCB 114020.)
GS0108076 Stauffer Chemical Co. (1956). Data table entitled: "Trithion
residues on cottonseed-1956." (Unpublished study received
March 1, 1957 under PP #0120; CDL:RCB 113303.)
GS0108077 Stauffer Chemical Co. (1959). Data table entitled: "Trithion
residue studies-Undelinted cottonseed." (Unpublished study
received Unknown date under PP #0120; CDL:RCB 113545.)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GS0108078 Stauffer Chemical Co. (1961). "Trithion residue studies-
cotton foliage." (Unpublished study received January 1, 1961
under PP #0334; CDLrRCB 114020.)
GS0108079 Stauffer Chemical Co. (1959). Data table entitled: "Trithion
Residue Studies-Figs." (Unpublished study received Unknown
date under PP #0120; CDL:RCB 113545.)
GS0108080 Stauffer Chemical Co. (1957). Olives-Trithion residue studies,
Section D. (Unpublished study received December 1, 1957 under
PP #0159; CDL:RCB unknown.)
GS0108081 Stauffer Chemical Co. (1971). Trithion tea food additive
petition. Tea residue data. Report (FSDS) Nos. A-1468, A-
1315, and B-2038. (Unpublished study received January 13, 1972
under PP #2H5006; CDLrRCB unknown.)
GS0108082 Stauffer Chemical Co. (1973). Supplementary data. Carbophenothion/
dried tea. Report (FSDS)' Nos. B-2038-2 and B-2038-4. (Unpublished
study received January 13, 1972 under PP #2H5006; CDLrRCB unknown.)
GS0108083 Stauffer Chemical Co. (1961). Tissue analysis. (Unpublished study
received January 1, 1961 under PP #0334; CDLiRCB 114020.)
GS0108084 Stauffer Chemical Co. (1962). Trithion residue identification
in cattle fat tissues. (Unpublished study received August 22,
1969 under PP #0366; CDL:RCB 114149.)
GS0108085 Stauffer Chemical Co. (1962). Carbophenothion residue identification
in cattle tissues. (Unpublished study received unknown date under
PP #0366; CDLrRCB 114149.)
GS0108086 Stauffer Chemical Co. (1962). Cattle spray program. (Unpublished
study received unknown date under PP #0366; prepared by Hazelton
Nuclear Scientific Corp.; CDL:RCB 114149.)
GS0108087 Stauffer Chemical Co. (1957). The analysis of milk of cattle
fed Trithion. (Unpublished study received December 1, 1957
under PP #0159; CDLrRCB "113405.)
GS0108088 Stauffer Chemical Co. (1957). Subacute feeding-cows. (Unpublished
study received December 1, 1957 under PP #0159; prepared by Hazelton
Nuclear Scientific Corp., CDLrRBC 113406.)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GS0108089 Stauffer Chemical Co. (1961). Milk analysis. (Unpublished study
received January 1, 1961 under PP #0334; CDL:RCB 114020.)
GS0108090 Handbook of Acute Toxicity of Chemicals to Fish and Aquatic
Invertebrates (1980), USDI/FWS, Resource Publication 137.
GS0108091 Beltsville Lab (EPA) static Jan. test #1002 (July 16, 1976) 96-hour
Rainbow Trout Study.
GS0102092 Stauffer Chemical Co. (1956). Section A. (Unpublished study
received June 1, 1956 under PP #0084; CDL:RCB 113229.)
GS0108093 Stauffer Chemical Co. (1961). Section A. (Unpublished study
received January 1, 1961 under PP #0334; CDLtRCB 114023.)
GS010094 Stauffer Chemical Co. (1973). Section A. (Unpublished study
received unknown date under PP #2H5006; CDL:RCB Unknown.)
GS010095 Stauffer Chemical Co. (1978). Acute Delayed Neurotocity.
(Unpublished study received unknown date under EPA Registration
No. 476-2162.)
GS010096 Stauffer Chemical Co. (1966). Three Generation Reproduction -
Rats. (Unpublished study received unknown date; CDLrTOX 250969.)
GS010097 Gaines, T.B. (1969). Acute Toxicology of Pesticides. Toxicology
and Applied Pharmocology (14):515-534.
-------
FIFHA SECTION 3{C)(2)(B) SUMMARY SHEET
EPA REGISTRATION NO.
PRODUCT NAME
APPLICANT'S NAME
DATE GUIDANCE DOCUMENT ISSUED
With respect to the requirement to submit "generic"data imputed by the FIFRA section 3(C)(2)(B) notice contained in the referenced
Guidance Document, I em responding hi the following manner:
O 1. I will submit data in a timely manner to satisfy the following requirements If the test procedures I will use deviate from (or are not
specified in) the Registration Guidelines or the Protocols contained in the Reports of Expert Groups to the Chemicals Group, OECD
Chemicals Testing Programme, I enclose the protocols that I will use:
O 2. I have entered into an agreement with one or more other registrants under FIFRA section 3(C)(2HB)(ii) to satisfy the following data
requirements. The tests, and any required protocols, will be submitted to EPA by:
NAME OF OTHER REGISTRANT
O 3. I enclose a completed "Certification of Attempt to Enter Into an Agreement with Other Registrants for Development of Data" with
respect to the following data requirements:
O 4. I request that you amend my registration by deleting the following uses (this option is not available to applicants for new products):
O 5. I request voluntary cancellation of the registration of this product. (This option is not available to applicants for new products.)
REGISTRANT'S AUTHORIZED REPRESENTATIVE
SIGNATURE
DATE
EPA Form 8580-1 (1O-82)
-------
Appendix II-3
OMB Appro*'No. 20OMX68 fExpires: 1231-S3;
(To gimlify. certify ^LL tour hems)
CERTIFICATION OF ATTEMPT TO ENTER
INTO AN AGREEMENT WITH OTHER REGISTRANTS
FOR DEVELOPMENT OF DATA
1. 1 am duly authorized to represent the following firm(s) who are subject to the require-
ments of • Notice under FIFRA Section 3{c)(2)(B) contained in a Guidance Document
Ito submit data concerning the active ingredient:
NAME OF FIRM
GUIDANCE DOCUMENT DATE
ACTIVE INGREDIENT
EPA COMPANY NUMBER
(This firm or group of firms is referred to below as "my firm".)
2. My firm is willing to develop and submit the data as required by that Notice, if necessary. However, my firm would prefer to enter
into an agreement with one or more other registrants to develop jointly, or to share in the cost of developing, the following required
hems or data:
3. My firm has offered in writing to tnter into such an agreement. Copies of the offers art attichid.Thil offer was irrevocable and included an offer to b<
toound by an arbitration decision under FIFRA Section 3(c)l2)(B)(iii) rf final agreement on all terms could not be reached otherwise. This offer was mad:
to the following firm(s) on the following dated):
MAME OF FIRM
DATE OF OFFER
However, none of those f irm(s) accepted my offer.
4. My firm requests that EPA not suspend the registration(s) of my firm's product(s). if any of the firms named in paragraph (3) ablrv
have agreed to submit the data listed in paragraph (2) above in accordance with the Notice. I understand EPA will promptly inforr
me whether my firm must submit data to avoid suspension of its registration(s) under FIFRA Section 3(c)(2)(B). (This statemer
does not apply to applicants for new products.) I give EPA permission to disclose this statement upon request.
TY*EDNAME
SIGNATURE
DATE
-------
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-------
8
PRECAUTIONARY STATEMENTS
HAZARDS TO HUMANS
(I DOME3TC ANIMALS)
DANDER
ENVWONMENTAL HAZARDS
PHYSICAL OR CHEMCAL
HAZARDS
DRECTON9 FOR USE
> k l «Wrtan <* Fwtant kv to
RE-ENTRY STATEMENT
STORAGE AND
DISPOSAL
STORAGE
DISPOSAL:
lOol
CROP: -
RESTRICTED USE
PESTICIDE
For retail site to and us* only by Certified Appllcatori
or pertont under their direct tupervlslon ind only for
thote aiei covered by the Certified Applicator! Certifi-
cation.
PRODUCT
NAME
ACTIVE NOREOCNT:
MERT MOREDCNTS
TOTAL.
I OOOOt
THQ PRODUCT CONTAMS LB9 OF PER GALLON
KEEP OUT OF REACH OF CHILDREN
DANGER —POISON
STATEMENT Of PRACTICAL TREATMENT
r SWALLOWED:
r WHALED =
r M EVES
SEE SIDE PANEL FOR ADOrflONAL PRtCAUTIONAHY STATEMENTS
MFO BY :
TOWN. STATE =
^ESTABLISHMENT NO.
EPA REGISTRATION NO
NET CONTENTS =
= €3
CROP:
CROP:
CROP:
CROP:
CROP:
WARRANTY STATEMENT
-------
APPENDIX IV-2
LABELING REQUIREMENTS OF THE FIFRA, AS AMENDED (REFER TO THE SAMPLE LABELS FOLLOWING)
ITEM
1
2
3
4
5
6A
6B
7
7A
7B
LABEL ELEMENT
Product name
Company name
and address
Net contents
EPA Est. No.
EPA Reg. No.
Ingredients
statement
Pounds/gallon
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where dosage
given as Ibs.
ai/unit area
All products
All products
All products
PLACEMENT ON LABEL
REQUI RED
Front panel
None
None
None
None
Front panel
Front panel
Front panel
Front panel
Front panel
PREFERRED
Center front
panel
Bottom front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel,
immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the main
ingredients
statement
Above signal
word
Immediately
below child
hazard
warning
COMMENTS
If registrant is not the producer, must
be qualified by "Packed for . . .,"
"Distributed by. . .," etc.
May be in metric units in addition to
U.S. units
Must be in similar type size and run
parallel to other type.
May appear on the container instead of
the label.
Text must run parallel with other text
on the panel.
All front panel precautionary statements
must be grouped together, preferably
blocked.
Note type size requirements.
Note type size requirements.
-------
APPENDIX IV-2 (continued)
ITEM
7C
7D
7E
8
8A
SB
LABEL ELEMENT
Skull & cross-
bones and word
POISON (in red)
Statement of
practical
treatment
Referral
statement
Side/back panel
precautionary
statements
Hazards to
humans and
domestic
animals
Environmental
hazards
APPLICABILITY
OF REQUIREMENT
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxicity
All products
in Categories
I, II, and III
All products
where pre-
cautionary
labeling
appears on
other than
front panel.
All products
All products
in Categories
I, II, and III
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
Category I :
Front panel
unless refer-
ral statement
is used.
Others:
Grouped with
side panel
precautionary
statements.
Front panel
None
None
None
PREFERRED
Both in close
proximity to
signal word
Front panel
for all.
Top or side
of back panel
preceding
directions
for use
Same as above
Same as above
COMMENTS
>
Must be grouped under the headings in
8A, SB, and 8C; preferably blocked.
Must be preceded by appropriate signal
word.
Environmental hazards include bee
caution where applicable.
-------
APPENDIX IV-2 (continued)
ITEM
8C
9A
9C
10A
IOC
10D
U.S.
LABEL ELEMENT
Physical or
chemical
hazards
Restricted
block
Misuse
statement
Re-entry
statement
Storage and
disposal block
Directions
for use
APPLICABILITY
OF REQUIREMENT
All pressurized
products, others
with flash
points under
150°F
All restricted
products
All products
All
cholinesterase
inhibitors
All products
All products
PLACEMENT ON LABEL
REQUIRED
None
Top center
of front
panel
Immediately
following
statement of
classifica-
tion or
ahead of
directions
for use
In the
directions
for use
In the
directions
for use
None
PREFERRED
Same as above
Preferably
blocked
Immediately
after misuse
statement
Immediately
before
specific
directions
for use or
at the end of
directions
for use
None
COMMENTS
Includes a statement of the terms of
restriction. The words "RESTRICTED USE
PESTICIDE" must be same type size as
signal word.
Must be set apart and clearly distin-
guishable from from other directions
for use.
May be in metric as well as U.S. units
-------
Appendix III-l
PRODUCT SPECIFIC DATA REPORT
EPA Registration No. Guidance Document for
Date
Registration
Guideline No.
§158.20
PRODUCT
CHEMISTRY
61-1
61-2
61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-10
63-11
63-12
63-13
63-14
63-15
63-16
63-17
63-18
63-19
Name of Test
Identity of
ingredients
Statement of
composition
Discussion of
formation of
ingredients
Preliminary
analysis
Certification of
limits
Analytical methods
for enforcement
limits
Color
Physical state
Odor
Melting point
Boiling point
Density, bulk-
density/ or
specific gravity
Solubility
Vapor pressure
Dissociation
constant
Octanol/water
partition
coefficient
PH
Stability
Oxidizing/reducing
reaction
Flammability
Explodability
Storage stability
Viscosity
Miscibility
Test not
required
for my
product
listed
above
(check
below)
I am complying with
data requirements by
Citing MRID#
Submit-
ting
Data
(At-
tached)
•
(For EPA Use Only)
Accession Numbers
Assigned
-------
63-20
63-21
§158.135
TOXICOLOGY
81-1
81-2
81-3
81-4
81-5
81-6
Corrosion
characteristics
Dielectric break-
down voltage
Acute oral LD-50,
rat
Acute dermal
LD-50
Acute inhalation,
LC-50 rat
Primary eye
irritation, rabbit
Primary dermal
irritation
Dermal sensitiza-
tion
-------
Appendix IV-3
PHYSICAL-CHEMICAL HAZARDS
Criteria
I. Pressurized Containers
A.
Flashpoint at or below
20°F; or if there is a
flashback at any valve
opening.
B,
Flashpoint above 20°F
and not over 80°F; or
if the flame extension
is more than 18 inches
long at a distance of
6 inches from the
valve opening.
ALL OTHER PRESSURIZED
CONTAINERS
II. Non-Pressurized Containers
A. Flashpoint at or below
20°F.
B. Flashpoint above 20°F
and over 80°F.
C. Flashpoint over 80°F
and not over 150°F.
D. Flashpoint above
150°F.
Required Label Statement
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame. Do
not puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
-------
Appendix IV-5
STORAGE AND DISPOSAL INSTRUCTIONS FOR PESTICIDES
All products are required to bear specific label instructions
about storage and disposal. Storage and disposal instructions
must be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need not include the heading
"STORAGE AND DISPOSAL." The STORAGE AND DISPOSAL heading
must appear in the minimum type size listed below:
Size of label
front panel in
square inches
Required type size
for the heading
STORAGE AND DISPOSAL
(all capitals)
10 and under 6 point
Above 10 to 15 8 point
Above 15 to 30 10 point
Over 30 12 point
Storage and disposal instructions must be set apart and
clearly distinguishable from other directions for use.
Blocking storage and disposal statements with a solid line is
suggested as a means of increasing their prominence.
A. Storage Instructions;
All product labels are required to have appropriate storage
instructions. Specific storage instructions are not prescribed
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors:
1. Conditions of storage that might alter the composition or
usefulness of the 'pesticide. Examples could be temperature
extremes, excessive moisture or humidity, heat, sunlight,
friction, or contaminating substances or media.
2. Physical requirements of storage which might adversely
affect the container of the' product and its ability to
continue to function properly. Requirements.might include
positioning- of the container in storage", storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock of friction.
3. Specifications for handling the pesticide container,
including movement of container within the storage area,
proper opening and .closing procedures (particularly for
opened containers), and measures to minimize exposure
while opening or closing container.
-------
Appendix IV-5
(continued)
4. Instructions on what to do if the container is damaged in
any way, or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs
5.' General precautions concerning locked storage, storage in
original container only, and separation of pesticides
during storage to prevent cross-contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original container and placement in
locked storage areas.
B. Pesticide Disposal Instructions;
The label of all products, except those intended solely for
domestic use, must bear explicit instructions about pesticide
disposal. The statements listed below contain the exact wording
that must appear on the label of these products:
1. The labels of all products, except domestic use, must
contain the statement, "Do not contaminate water, food,
or feed by storage or disposal."
2. Except those products intended solely for domestic use,
the labels of all products that contain active ingredients
appearing on the "Acutely Hazardous" Commercial Pesticide
Products List (RCRA "E" List) at the end of this appendix
or are assigned to Toxicity Category I on the basis of
oral or dermal toxicity, skin or eye irritation potential,
or Toxicity Category I or II on the basis of acute inhala-
tion toxicity must bear the following pesticide disposal
statement:
"Pesticide wastes are acutely hazardous. Improper dis-
posal of excess pesticide, spray mixture, or rinsate is
a violation of Federal Law. If these wastes cannot be
disposed of by use according to label instructions,
contact your State Pesticide or Environmental Control
Agency, or the Hazardous Waste representative at the
nearest EPA Regional Office-for guidance."
The labels of all products, except those intended for
domestic use, containing active or inert ingredients
that appear on the "Toxic" Commercial Pesticide Products
List (RCRA "F" List) at the end of this appendix or
presently meet any of the criteria in Subpart C, 40 CFR
261 for a hazardous waste must bear the following pesticide
disposal statement:
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Appendix IV-5
(continued)
"Pesticide wastes are toxic. Improper disposal of excess
pesticide, spray mixture, or rinsate is a violation of
Federal Law. If these wastes cannot be disposed of by
use according to label instructions, contact your State
Pesticide or Environmental Control Agency, or the Hazardous
Waste representative at the nearest EPA Regional Office
for guidance."
Labels for all other products, except those intended for
domestic use, must bear the following pesticide disposal
statement:
"Wastes resulting from the use of this product may be
disposed of on site or at an approved waste disposal
facility."
3. Products intended for domestic use only must bear the
following disposal statement: "Securely wrap original
container in several layers of newspaper and discard in
trash."
C. Container Disposal Instructions
The label of each product must bear container disposal
instructions appropriate to the type of container.
1. All products intended for domestic use must bear one
of the following container disposal statements:
Container Type
Statement
Non-aerosol products
(bottles, cans, jars)
Non-aerosol products
(bags)
Aerosol products
Do not reuse container (bottle, can, jar) .
Rinse thoroughly before discarding in trash.
Do not reuse bag. Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or puncture.
2. The labels for all other products must bear container disposal
instructions, based on container type, listed below:
Container Type
Statement
Metal
containers
(non-aerosol)
Triple rinse (or equivalent). Then offer
for recycling or reconditioning', or puncture
and dispose of in a sanitary landfill, or by
other procedures approved by state and local
authorities.
Plastic containers
Triple rinse(or equivalent).Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or
incineration, or, if allowed by state and
local authorities, by burning. If burned,
stay out of smoke.
Glass containers
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved state and local procedures.
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Appendix IV-5
(continued)
Container Type
Statement
Fiber drums
with liners
Paper and
plastic bags
Compressed gas
cylinders
Completely empty liner by shaking and
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reused-!-, dispose of in the same manner.
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out of smoke.
Return empty cylinder for reuse (or
similar wording).
•'-Manufacturer may replace this phrase with one indicating whether
and how fiber drum may be reused.
2. The labels for all other products must bear container
disposal instructions, based on container type, listed
on the first page of this Appendix.
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Appendix IV-5
(continued)
Pesticides that are hazardous wastes under 40 CFR 261.33(e) and (f)
when discarded.
"Acutely Hazardous" Commercial Pesticides (RCRA "E" List)
Active Ingredients, (no inerts);
Acrolein
Aldicarb
Aldrin
Allyl alcohol
Aluminum phosphide
4-Aminopyridine
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p-Chloroaniline
Cyanides (soluble cyanide salts, not specified elsewere)
Cyanogen chloride
2-Cyclohexyl-4,6-dinitrophenol
Dieldrin
0,0-Diethyl S-[2-ethylthio)ethyl] phosphorodithioate
(disulfoton, Di-Syston)
0,0-Diethyl 0-pyrazinyl phosphorothioate (Zinophos)
Dimethoate
0,0-Dimethyl 0-p-nitrophenyl phosphorothioate (methyl parathion)
4,6-Dinitro-o-cresol and salts
4,6-Dinitro-o-cyclohexylphenol
2,4 Dinitrophenol
Dinoseb
Endosulfan
Endothall
Endrin
Famphur
Fluoroacetamide
Heptachlor
Hexanethyl tetraphosphate
Hydrocyanic acid
Hydrogen cyanide
Methomyl
.alpha-Naphthylthiourea (ANTU)
Nicotine and salts
Octamethylpyrophosphoramide (OMPA, schradan)
Parathion
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Appendix IV-5
(continued)
"Acutely Hazardous" Commercial Pesticides (RCRA "E" List)
Active Ingredients continued;
Phenylraercuric acetate (PMA)
Phorate
Potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
Strychnine and salts
0,0,0,0-Tetraethyl dithiopyrophosphate (sulfotepp)
Tetraethyl pyrophosphate
Thallium sulfate
Thiofanox
Toxaphene
Warfarin
Zinc phosphide
There are currently no inert ingredients for commercial pesticides
on the "Acutely Hazardous" List (RCRA "E" List).
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Appendix IV-5
(continued)
"Toxic" Commercial Pesticide Products (RCRA "F" List)
Active Ingredients:
Acetone
Acrylonitrile
Amitrole
Benzene
Bis(2-ethylhexyl)pthalate
Cacodylic acid
Carbon tetrachloride
Chloral (hydrate)
Chlordane (technical)
Chlorobenzene
4-Chloro-m-cresol
Chloroform
o-Chlorophenol
4-Chloro-o-toluidine hydrochloride
Creosote
Cresylic acid
Cyclohexane
Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[c,d]-pentalen-2-one
(kepone, chlordecone)
1,2-Dibromo-3-chloropropane (DBCP)
Dibutyl phthalate
S-3,3-(Dichloroallyl diisopropylthiocarbamate (diallate, Avadex)
o-Dichlorobenzene
p-Dichlorobenzene
Dichlorodifluoromethane (Freon 12®)
3,5-Dichloro-N-(1,1-dimethy1-2-propyny1) benzamide (pronamide,Kerb)
Dichloro diphenyl dichloroethane (ODD)
Dichloro diphenyl trichloroethane (DDT)
Dichlorethyl ether
2,4-Dichlorophenoxyacetic, esters and salts (2,4-D)
1,2-Dichloropropane
1,3-Dichloropropane (Telone)
Dimethyl phthalate
Ethyl acetate
Ethyl 4,4'-dichlorobenzilate (chlorobenzilate)
Ethylene dibromide (EDB)
Ethylene dichloride
Ethylene oxide
Formaldehyde
Furfura-l
Hexachlorobenzene
Hexachlorocyclopentadiene
Hexachloroethane
Hydrofluoric acid
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Appendix IV-5
(continued)
"Toxic" Commercial Pesticide Products (RCRA "F" List)
Active Ingredients;
Isobutyl alcohol
Lead acetate
Lindane
Maleic hydrazide
Mercury
Methyl alcohol
Methyl bromide
Methyl chloride
2,2'-Methylenebis (3,4,6-trichlorophenol) (hexachlorophene)
Methylene chloride
Methyl ethyl ketone
4-Methyl-2-pentanone (methyl rsobutyl ketone)
Naphthalene
Nitrobenzene
p-Nitrophenol
Pentachloroethane
Pentachloronitrobenzene (PCNB)
Pentaclorophenol
Phenol
Phosphorodithioic acid, 0,0-diethyl, methyl ester
Propylene dichloride
Pyridine
Resorcinol
Safrole
Selenium disulfide
Silvex
1,2,4,5-Tetrachlorobenzene
1,1,2,2-Tetrachloroethane
Tetrachloroethylene
2,3,4,6-Tetrachlorophenol
Thiram
Toluene
1,1,1-Trichloroethane
Trichloroethylene
Trichloromonofluoromethane (Freon 11®)
2,4,5-Trichlorophenol
2,4,6-Trichlorophenol
2,4,5-Trichlorophenoxyacetic acid (2,4,5-T)
Xylene
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Appendix IV-5
(continued)
"Toxic" Commercial Pesticide Products (RCRA "F" List)
Inert Ingredients;
Acetone
Acetonitrile
Acetophenone
Acrylic acid
Aniline
Benzene
Chlorobenzene
Chloroform
Cyclohexane
Cyclohexanone
Dichlorodifluoromethane (Freon 12®)
Diethyl phthalate
Dimethylamine
Dimethyl phthalate
1,4-Dioxane
Ethylene oxide
Formaldehyde
Formic acid
Isobutyl alcohol
Meleic anhydride
Methyl alcohol (methanol)
Methyl ethyl ketone
Methyl methacrylate
Naphthalene
Saccharin and salts
Thiourea
Toluene
1,1,1-Trichloroethane
1,1,2-Trichloroethane
Trichlorofluoromethane (Freon 11®)
Vinyl chloride
Xylene
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