GUIDANCE DOCUMENT FOR THE
REREGISTRATION OF PESTICIDE PRODUCTS
CONTAINING
FONOFOS
(041701)
AS THE ACTIVE INGREDIENT
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20460
MARCH, 1984
-------
CHEMICAL INFORMATION FACT SHEET FOR FONOFOS
Fact Sheet Number:
Date.Issued:
1. Description of chemical
Generic Name: 0-ethyl S-phenyl ethylphosphonodithioate
Common name: Fonofos
Trade name: Dyfonate
EPA Shaughnessy code: 041701
Chemical abstracts service (CAS) number: 944-22-9
Year of initial registration: 1967
Pesticide type: Insecticide
Chemical family: organophosphate
U.S. and foreign producers: Stauffer Chemical Co.
2. Use patterns and formulations
Fonofos is a soil applied insecticide used primarily on
corn (95%). It is used also on various vegetable crops,
ornamentals, home lawns and home vegetable gardens and
commercial turf. Fonofos is applied mainly with ground
equipment. Aerial applications are made to hybrid seed
corn. Application rates vary from 1-4 Ibs./acre. The
usual carrier is water.
3. Science Findings
Summary of Science findings: Technical fonofos is a non-
systemic insecticide. It is not absorbed by foliage and
is not translocated within the plant body. Fonofos
accumulates in carrots. It is a cholinesterase inhibitor.
Fonofos is immobile in sandy loam soils and in silt loam
soils but mobile in quartz sand. Available data 'are
insufficient to fully assess the toxicological and
environmental effects of fonofos. Data gaps exist in
both toxicological and environmental areas. Available
data suggest fonofos is moderately to highly toxic to
birds and highly toxic to fresh and salt water organisms.
The tolerance for fonofos residues is set at 0.5 ppm for
asparagus and at 0.1 ppm for all other crops on which it
is used.
Fonofos is a yellow liquid with a mercaptan-like odor.
The boiling point is 212°F (100°C) and the melting point
is -32°C at 0.3mm H Fonofos is almost insoluble in water
and miscible in common organic solvents.
-------
-JZ-
Toxicology characteristics:
Technical fonofos is highly toxic based on acute
oral, dermal, eye and inhalation effects.
Results of toxicological studies on fonofos are as
follows:
-Oral LDso , ranges from 3.16-18.5 mg/kg
-Dermal LD5Q , ranges from 121-359 mg/kg
-Primary Eye Irritation, negative to 0.01 ml; 0/6 dead
-Inhalation LC^Q, 0.9 mg/L (male and female combined)
r3 generation reproduction rat, reproductive and
fetotoxic NOEL= 31.6 ppm (highest dose tested)
-2 year dog feeding study - NOEL, ChE and non-cholinergic=
8 ppm; LEL, ChE and non-cholinergis= 60 ppm
Available data are insufficient to fully assess the
toxicological properties of fonofos. Data gaps must be
filled in areas of neurotoxicity, subchronic and chronic
toxicity, oncogenicity and mutagenicity before a total
risk assessment can be made.
Physiological and Biochemical Behavioral Characteristics:
Fonofos is not absorbed by foliage and is not translocated
in the plant body. It is a cholinesterase inhibitor and
accumulates in carrots.
Environmental Characteristics:
Fonofos is immobile in sandy loam and silt loam soils.
It is mobile in quartz sand. It degrades in aerobic
soils with a half-life of approximately 3-16 weeks.
In the field, fonofos dissipates with a half-life of
approximately 4-7 weeks. Fonofos is moderately persistent.
Ecological Characteristics:
Fonofos is moderately to highly toxic to birds and highly
toxic to freshwater fish and salt water organisms.
Simulated avian field studies indicate granular treatments
of fonofos may result in some mortality, as well as brain
AChE inhibition, but that effects are not likely to
diminish wildlife resources.
See under Data Gaps for additional data requirements.
-------
-3-
Tolerance assessments:
Tolerances are established for residues of the insecticide
0-ethyl S-phenyl ethylphosphonodithioate, including its
oxygen analog 0-ethyl S-phenyl ethylphosphonothioate, in
or on raw agricultural commodities as follows (40 CFR
180.221):
0.5 part per million in or on asparagus.
0.1 part per million (negligible residue) in or on bean
forage, bean vine hay, fresh corn including sweet corn
(kernels plus cob with husk removed), corn grain (in-
cluding popcorn), corn forage or fodder (including
sweet corn, field corn, and popcorn), fruiting vege-
tables, leafy vegetables, mint (peppermint, spearmint,
peppermint hay, and spearmint hay), pea forage, pea
vine hay, peanuts, peanut forage, peanut hay, peanut
hulls, root crop vegetables, seed and pod vegetables,
sorghum (grain, fodder, and forage), soybean forage,
soybean hay, strawberries, sugar beet tops, and
sugarcane.
4. Summary of Regulatory Position and Rationale;'
; The Agency has determined that certain formulations of
fonofos warrant classification as restricted use pesticides.
These include all emulsifiable concentrates 44% or greater
and the 20% granular formulation. £A 24-hour interim
reentry interval has been established for all uses of
fonofos including the home lawn and home vegetable garden_
use. Gloves and shoes must be worn when applying fonofos.^
5. Summary of Major Data Gaps *
0 Delayed neurotoxicity - hen
0 90 day rodent feeding study
0 90 day neurotoxicity study - hen/mammal
0 Chronic toxicity study-rodent
0 Oncogenicity study
0 Teratogencity study - 1 species
0 Gene mutation study
0 Chromosomal aberration study
0 Reentry Data
0 Acute LCso - freshwater invertebrates
Fish early life cycle stage and aquatic invertebrate
lifecycle studies
Residue data in:
- root and tuber vegetables
- leaves of root and tuber vegetables
- fruiting vegetables (except curcubits)
- cereal grains
- forage, fodder and straw of cereal grains
- miscellaneous crops ( asparagus, peanuts.
o
o
-------
-4-
sugarcane and tobacco)
0 Poultry feeding study and ruminant feeding study
0 Photodegradation in water, soil and air
0 Hydrolysis study
0 Metabolism study in anaerobic soil
0 Mobility studies (leaching and adsorption/desorption,
volatilty lab, and volatility field)
0 Soil dissipation study
0 Accumulation studies - rotational crops and fish
6. Contact person at EPA (Name, address, and telephone number)
Contact Person
William H. Miller, PM 16, Telephone No. (703)557-2600
Registration Division (TS-767)
Office of Pesticide Programs
Environmental Protection Agency
401 M Street SW
Washington, DC 20460
DISCLAIMER: The information presented in this Chemical
Information Fact Sheet is for informational purposes only and
may not be used to fulfill data requirements for pesticide
registration and reregistration.
*All major data gaps are to be filled by March 31, 1987.
-------
TABLE OF CONTENTS
Introduction 1~3
I. Regulatory Position 4-8
II. Requirement for Submission of Generic Data 77
III. Requirement for Submission of Product-Specific
Data 80
IV. Submission of Revised Labeling and Packaging
Information 81
A. Label Contents « « 81
1. Product Name 81
2. Company Name and Address 81
3. Net Contents 81
4. Product Registration Number 82
5. Producing Establishment 82
Registration Number 82
6A Ingredient Statement 82
6B Pounds Per Gallon Statement. 82
7. Front Panel Precautionary Statements 82
7A Child Hazard Warning Statements 83
7B Signal Word 83
7C Skull and Crossbones and Word Poison 83
7D Statement of Practical Treatment 83
7E Referral Statement 83
8. Side/Back Panel Precautionary Labeling 83
8A Hazard to Humans and Domestic Animals 84
8B Environmental Hazard ....... 84
8C Physical or Chemical Hazard 84
9 Misuse Statement 85
10A Storage and Disposal Block 85
10B Directions for Use 85
B. Collateral Information ............... 85
V. Instructions for Submission 86
-------
APPENDICES
II-l Bibliography 87-94
II-2 FIFRA §3(c)(2)(B) Summary Sheet - EPA Form 8580-1 . 101
II-3 Certification of Attempt to Enter Into an Agreement
With Other Registrants for Development of Data
III-l
IV-1
IV- 2
IV- 3
IV- 5
Note :
EPA Form 8580-6
Product Specific Data Report (End-Use Products) . .
40 CFR §162.10 Labeling Requirements
Table of Labeling Requirements
Physical/Chemical Hazards Labeling Statement. . . .
Storage and Disposal Instructions
Appendices IV-4 and IV-6 are not germane to this
102
103-104
105-107
108
109-117
document and are not included.
11
-------
INTRODUCTION
The Federal Insecticide, Fungicide, and Rodenticide Act
(FIFRA Section 3(g), as amended in 1978, directs EPA to
reregister all pesticides as expeditiously as possible. Eac"h
registrant of a manufacturing use product of the active
ingredient who wishes to continue to sell or distribute that
product must apply for reregistration.
To fulfill this Congressional mandate, we have established
the Registration Standards program which will review all pesti-
cide active ingredients first registered before January 1,
1977. These pesticides will be reviewed in use clusters
which are prioritized on the basis of a ranking scheme giving
preference to pesticides used on food and feed crops.
The Registration Standards program involves a thorough
review of the scientific data base underlying pesticide
registrations and an identification of essential but missing
studies which may not have been required when the product
was initially registered or studies that are now considered
insufficient. Our reassessment results in the development
of a regulatory position, contained in this document, on
each pesticide and its uses. The regulatory position may
require the registrant to modify product labels to provide
additional precautionary statements, restrict the use of the
pesticide to certified applicators, provide reentry intervals,
modify uses or formulation types, specify certain packaging
limitations, or other requirements to assure that proper use
of the pesticide poses no potential adverse effects to human
health or the environment.
The scientific review, which is not contained herein
but is available upon request, concentrates on the technical
grade of the active ingredient and identifies missing generic
data. 'However, during the review of these data we are also
looking for potential hazards that may be associated with
the formulated (end-use) products that contain the active
ingredient. If we find serious concerns, we will bring
formulated products under the provisions of the Registration
Standards program to the extent necessary to protect the
public.
EPA has the authority under FIFRA §3(c)(2)(B) to require
that certain registrants submit generic data that will answer
our questions regarding the hazard that may result from the
intended use of the pesticide under review. Further, §3(c)
(2)(B) provides that these data are to be submitted by
those registrants who do not qualify for the formulator's
exemption [FIFRA §3(c)(2)(D)]. Normally, this means that
the registrants who are responsible for filling the data
gaps are the manufacturing-use product producers (basic
-------
suppliers of the active ingredient). However, end-use producers
will not qualify for the formulator's exemption if the source
of their active ingredient: (1) is not registered with EPA,
and/or (2) is produced by the registrant's firm, or a firm
which has ownership in common with the registrant's firm.
These end-use producers can qualify for the formulator's
exemption if they change their source of supply to a registered
source, provided the source does not share ownership in
common with the registrant's firm. If the end-use product
registrant decides to switch sources, a new Confidential
Statement of Formula, EPA Form 8570-4, must be submitted to
the appropriate Product Manager within 90 days of receipt of
this Guidance Document. The chart on the following page
shows what is generally required of those who do and do not
qualify for the formulator's exemption in the Registration
Standards program.
If you decide to request the Agency to discontinue the
registration of any of your products subject to the reregistra-
tion requirements of this Guidance Document, please notify
the Product Manager named in the cover letter, within 90
days from the receipt of this document, that you wish to
voluntarily cancel the registration(s). If you decide to
maintain your product registrations), you must provide the
information described in the following pages within the time-
frames outlined. EPA will issue a notice of intent to cancel
or suspend the registration of any currently registered
product if you fail to comply with the requirements set
forth in this Guidance Document.
This Guidance Document will be supplemented by EPA with
additional information about compliance with data support
requirements. In Monsanto v. Administrator, EPA was recently
enjoined from implementing in any way the "mandatory data
licensing" aspects of §3(c)(l)(D) of FIFRA. EPA is assessing
the implications of the injunction for the reregistration
process. Because this situation is currently unresolved, EPA
has decided to proceed with the requirements in this Guidance
Document which do not relate to compliance with the §3(c)(l)(D)
provisions and to supplement the Document with additional
guidance when circumstances permit. Failure to comply with
the provisions of the subsequent guidance will also result
in issuance by EPA of an intent to cancel the affected product
registration(s) .
Registrants are reminded that §6(a)(2) of FIFRA requires
you at any time to submit factual information raising concerns
of possible unreasonable adverse effects of a pesticide. You
should notify the Agency of interim results of studies in
progress if those results show possible unreasonable adverse
effects.
-------
PRODUCTS SUBJECT TO THE
REGISTRATION STANDARDS PROGRAM
ACTION(S) REQUIRED TO
MAINTAIN REGISTRATION
I. Products That Do Not Qualify
For The Formulator's Exemption
A. Single Active Ingredient
Products*
These products must be
tered. To obtain reregistration
labeling, packaging and data
requirements must be satisfied
in accordance with the Regis-
tration Standards Guidance
Document.
B. Multiple Active Ingredient
Products
These products will not be
reregistered at this time.
However, generic data required
to continue the registration of
the active ingredient under
review, as described in the
Registration Standards Guidance
Document, will be required and
some labeling precautions may
also be required.
II. Products That Do Qualify For
The Formulator's Exemption
Only when additional restric-
tions or labeling are needed to
protect man or the environment
will these products be subject
to the Registration Standard
requirements. Affected products
will be dealt with in a variety
of ways, including but not
limited to the Label Improvement
Program and special intent
to cancel notices.
* End-use products of registrants who also produce a manufacturing-
use product will not be required to be reregistered provided that
registrant fulfills the requirements specified in the Guidance
Document for manufacturing-use product(s). Such end-use products
will be subject to the labeling changes required for products in "II
above. If there are no manufacturing-use products registered by any
company end-use products will be required to be reregistered.
NOTE: If all registrants in "I" above fail to meet the requirements
I-A and B above, then the registrants in "II" lose their right to
qualify for the formulator's exemption and become subject to the
requirements in I-A and B.
3
-------
I. REGULATORY POSITION AND RATIONALE
A. Introduction
guidance document describes the Agency's regulatory position
for all products containing the insecticide fonofos. The position
is based on an evaluation of all the accepted uses of registered
pesticide products under Section 3 and 24(c) of the FIFRA, with
fonofos as the pesticide active ingredient. Other considerations
include the known chemical and toxicological characteristics
of the pesticide chemical and the established tolerances for
residues in or on food commodities. From these considerations
the Agency sets forth the data and labeling requirements that
must be met by registrants, and applicants of fonofos products
in order for their products to be registered under this
document. Only those registration requirements for currently
registered products containing fonofos are addressed here.
Refer to the attached site/pest document for a listing of
currently registered sites and pests. Future products
that differ appreciably from those described in this guidance
document may require that amendments be made to this document
to reflect the differences.
B. Description of Chemical and Use Profile
Fonofos is a non-systemic organophosphorus insecticide
(O-ethyl S-phenyl ethylphosphonodithioate) developed and
initially marketed by Stauffer Chemical Company in 1967 under
the trade name Dyfonate®. There is no American National
-------
Standards Institute (ANSI) name for fonofos. However, fonofos
is the official common name of the British Standards Institute
(BSI), the International Standards Organization (ISO), and the
Entomological Society of America (ESA). The current Chemical
Abstract Service (CAS) registry number is 944-22-9. The Agency's
Pesticide Chemical Code number is 041701.
Technical fonofos is a yellow liquid with a pungent mercaptan-
like odor. The empirical formula is C10H15OPS2- The molecular
weight is 246.3. Other physical and chemical characteristics
of fonofos include a boiling point of 212°F at 0.3 mm Hg, a
melting point of ~25°F, a vapor pressure of 2.1 x 10~4 mm Hg
at 25°C, a pH of 4-6, and a specific gravity of 1.154. Fonofos
is almost insoluble in water (13 ppm at 20°C), but is miscible
in common organic solvents (kerosene, xylene, MIBK, acetone
and ethanol). Stauffer Chemical Company is the sole producer
of fonofos in the United States.
There are 10 federally registered, sole-active-ingredient
formulations of fonofos which include 2, 5, 10, 15 and 20%
granular formulations and 1 Ib and 4 Ib/gallon emulsifiable
concentrate formulations. There is one federally-registered,
multiple-active-ingredient formulation containing 1 Ib.
emulsifiable concentrate of fonofos and 4 Ibs. pebulate
(Tillam®) and two 24(c) "Special Local Need" registrations
which contain fonofos and thiram. In addition, -there
are 11 intrastate and 19 sole-active-ingredient 24(c)
-------
registrations. There are no products registered for
manufacturing-use only.
Fonofos is used for the control of corn borers, garden
symphylans, wireworms, and other soil insects. The major use
(about 95%) is on corn; followed by peanuts and sugar beets
(about 2% each), white (Irish) potatoes (about 1%), and less
than 1% each on sugarcane and tobacco. Minor amounts are
also used on some vegetable crops, lawns, and turf. There is
a 2% granular formulation registered for home lawn and garden
use; no usage data are available for this use.
Fonofos is primarily a soil-incorporated insecticide. Formu-
lations are applied pre-plant, at-planting, and post-emergence
to the soil using ground application equipment. Foliar
applications to corn and sorghum may be applied using aerial
equipment. The registered 2% granular formulation would be
applied from a canister or by lawn fertilizer spreader.
Emulsifiable concentrates of fonofos may be tank-mixed with
certain herbicides and fluid fertilizers or water for use
on some field and vegetable crops.
All of the emulsifiable concentrate formulations of fonofos, e,.g.
44% and greater, are restricted-use pesticides, and applicators
must be certified or work under the direct supervision of
applicators certified to apply these products (44 FR 45131,
-------
August 1, 1979).
C. REGULATORY POSITION
Based on a review and evaluation of all available data and
other relevant information on fonofos, the Agency has made the
following determinations:
1. Available data do not show that any of the criteria
listed in Section 162.11 (a) of Title 40 of the U.S. Code of
Federal Regulations have been met or exceeded for the uses of
fonofos listed in this Guidance Document. However, gaps in the
data base preclude the completion of the Agency's risk assessment.
2. Although the Agency is unable to complete a tolerance
reassessment because of critical residue chemistry data gaps,
the Agency concludes, based on available data, that no change
in present tolerances, other than a pending tolerance petition
for potatoes (see under TOLERANCE REASSESSMENT), is indicated
at this time.
3. Fonofos is a highly toxic pesticide and uses may involve
substantial human exposure to residues, but there is not suffi-
cient data available to determine the extent of worker protection
requirements such as reentry intervals. However, because of
the Agency's concern about fonofos exposure, a 24 hour interim
reentry interval has been established for all uses. Of particular
concern are the hybrid seed corn use, exposure when soils are
wet, and use in high exposure situations such as suckering of
tobacco. Also of concern is exposure to persons, especially
children, and pets from the 2% granular used for home lawns and
7
-------
vegetable gardens.
4. Residues of fonofos and its oxon have been found to
accumulate in carrots. Therefore, carrots should not be included
in any crop rotation system where fonofos is applied.
5. The restricted use classification for all emulsifiable
concentrate formulations containing fonofos at 44% and greater,
will continue. In addition, the Agency-has determined that the
20% granular formulation should be classified as a restricted
use product.
6. Manufacturing-use and end-use products containing fonofos
may be registered for sale, distribution, reformulation, and
use, subject to the terms and conditions specified in this
Guidance Document.
7. Registrants must provide, or agree to develop, additional
data as specified in the tables, in order to maintain existing
registrations or to permit new fonofos registrations.
D. REGULATORY RATIONALE
The Agency has determined that it will continue to allow the
registration of fonofos after considering the following:
1. Under FIFRA, the Agency cannot cancel or withhold regis-
tration simply because the data are missing or are inadequate
(see Sections 3(c)(2)(B) and 3(c)(7) of the FIFRA). Rather,
the issuance of this Guidance Document provides a mechanism for
identifying data needs. These data will be reviewed and evaluated
when they are received and the Agency will determine at that
8
-------
time whether they will affect the registrations of fonofos.
2. Data available are insufficient to fully assess the
toxicological properties of fonofos. Subchronic 90 day rat
and dog feeding studies are necessary to fulfill the data
requirements for fonofos. However, a review of the 90 day dog
study showed it to be supplementary, but an adequate 2 year
dog study on file permits fulfillment of the requirement for
the non-rodent study. Therefore, only a 90 day subchronic
rat study is required. There are several major data gaps
which are essential for determining the extent of the human
hazard. Studies must be submitted on neurotoxicity, subchronic
toxicity, chronic feeding toxicity, teratogenicity, oncogenicity,
and mutagenicity.
3. Available data are insufficient to fully assess the
environmental fate of fonofos. Data gaps exist in all categories
except aerobic soil metabolism. The preliminary laboratory
j
mobility study suggests that fonofos may be relatively immobile
in sandy loam and silt loam soils, and mobile in quartz sand.
It was not appreciably mobile in runoff water from a loam
soil, nor does it volatilize from soil, but it is fairly
volatile in water. It degrades in aerobic soils with a
half-life of approximately 3-16 weeks. In the field, fonofos
dissipates with a half-life of approximately 4-7 weeks. Data
indicate that fonofos is only moderately persistent. Fonofos
has been found in tailwater pit sediment and water samples at
<770 and <6 ppb, respectively. Fonofos is accumulated in
bluegill sunfish and has a bioconcentration factor of 150X in
bluegill edible tissue, but 80% of the accumulated 14C residues
9
-------
are depurated within 3 days. Preliminary laboratory leaching/
mobility and disappearance data indicate that fonofos may
have the potential for moving into ground water through sand
soil types. This preliminary assessment was based on a
laboratory soil, column test that was determined to be deficient.
A repeat of this test is therefore required. Preliminary data
from leaching/mobility and disappearance studies are insufficient
to impose a label restriction for fonofos at this time. (see
Table A page 45, footnote 9). The Agency has requested
additional data on leaching/mobility of fonofos, and following
review of the requested data, the Agency may impose label
restrictions to prevent possible ground water contamination.
4. Based on studies available to assess the hazard to
wildlife and aquatic organisms, fonofos is characterized as
moderately to highly toxic to birds and highly toxic to freshwater
fish and saltwater organisms. Simulated avian field studies
indicate that granular treatments of fonofos may result in some
mortality as well as brain AChE inhibition but that effects are
not considered likely to diminish wildlife resources. Further
10
-------
aquatic risk analysis is contingent upon submission of pertinent
environmental fate studies and data gap studies listed in the
Table for Ecological Effects. With respect to potential hazards
to federally endangered/ threatened species, fonofos is currently
being reviewed by the Agency and The Office of Endangered
Species (OES).
5. Reported pesticide incidents cited in the Pesticide
Incident Monitoring System (PIMS) through August 1977 include
21 incidents involving human injury- There were two reported
fatalities. In addition, numerous reports of cattle, dog,
raccoon, and fish deaths have been reported. These incidents
were largely the result of accidents and careless use of fonofos
and/or used containers that once contained fonofos.
6. No Federal reentry interval has existed prior to the
issuance of this guidance document for workers entering fields
treated with fonofos. Because fonofos is highly toxic and
uses of fonofos may involve substantial exposure to residues,
the Agency is requiring a 24 hour interim reentry interval for
all uses of fonofos. Several uses and use conditions are of
particular concern to the Agency. These include worker exposure
from the use of fonofos on hybrid seed corn and worker exposure
1 1
-------
from treated soil that is wet. The State of California is
reporting worker exposure problems with soil incorporated
pesticides similar to fonofos. California also requires at
least a 24 hour interval for toxicity category I pesticides.
The Agency is also concerned about fonofos used on other
crops where work tasks involve prolonged, intimate contact with
plant surfaces. Among these tasks are the topping and suckering
of tobacco. Another area of concern is exposure to individuals,
especially children, and pets from the home lawn and vegetable
garden uses of the 2% product. Although the 2% granular
formulation has a lower concentration of active ingredient than
the other granular formulations, the per unit application rate
for the active ingredient is equivalent to the per unit rate of
application for the 5, 10, 15, and 20% formulations. Therefore,
the Agency believes it is appropriate to impose an interim 24
hour reentry interval until data are submitted to enable the
Agency to evaluate the hazards of the homowner uses.
7. Preliminary data from rotation crop studies indicates that
carrots accumulate fonofos residues of approximately 0.4 to 1.31
ppm. The group tolerance for root and tuber crops is 0.1 ppm for
fonofos plus its oxon. Preliminary information also indicates
that carrots generally absorb more insecticide than any other crop
For this reason, a carrot crop rotation restriction is required.
8. Classification of Fonofos. The Agency has determined that
certain formulations of fonofos warrant classification as
restricted use pesticides. These include all emulsifiable con-
centrates 44% or greater and the 20% granular formulation. The
12
-------
restriction being imposed is limitation of use to certified
applicators or persons under, their direct supervision. Granular
formulations of 2%, 5%, 10% and 15% are not classified for
restricted use.
The criterion used for restricting the emulsifiable concen-
trates 44% and greater is the acute dermal toxicity of the
formulations. These formulations were restricted by regulation
on August 1, 1979 (44 FR 45132). The criterion used for restricting
the 20% granular formulation is the acute oral toxicity of the
formulation. The 20% granular formulation was proposed for
restricted use on August 1, 1979 (44 FR 45219). The Agency
never promulgated a final rule classifying the 20% granular
formulation for restricted use. The principal reasons for the
delay in promulgation has been the the concerns raised by
several registrants and the Scientific Advisory Panel over the
(
avian effects triggger and the concerns raised by Stauffer
Chemical Co. over the use of the acute oral trigger as a criterion
for restricted use classification. The Agency has decided that
the avian effects trigger should not, at this time, be used as
a basis for restricting fonofos granular formulations pending
further development of Agency efforts to develop data and
protocols for assessing avian hazards. However, granular
formulations of other active ingredients that were proposed for
restricted use in the same rule as fonofos granulars and which
have been demonstrated to be more hazardous than fonofos to
avian species may be classified for restricted use on the basis
13
-------
of adverse avian effects.
The Agency has also recently decided to cease using the
classification by regulation process as a routine mechanism for
classifying uses/formulations for restricted use. Classification
by regulation was developed as an optional procedure to classifying
through reregistration. An alternative mechanism was needed
because the programs to train and certify applicators was being
implemented beginning in 1975 and procedures for reregistration
had not been instituted at that time. The appropriate time to
consider classification decisions, however, is during the
development of the Registration Standard, which the Agency is
now able to do because the standard development process is
fully operational. Classifying through the standard will
enable the Agency to thoroughly evaluate the risks and benefits
of a restricted use classification and will be a more efficient
use of Agency resources.
The details on labeling requirements for the 20% granular
product, such as release for shipment dates, labeling of products
at the distributor and retail level and requirements for submitting
restricted use labeling to to the Agency for approval, have not
been finalized by the Agency. • However, the Agency has determined
that the restricted use labeling for the 20% granular formu-
lation is to be implemented in time for the 1986 growing season.
Labeling for the emulsifiable concentrates previously restricted
is to remain in place. Classification decisions on the granular
formulations of the other active ingredients that were proposed
14
-------
for restricted use at the same time as the fonofos 20% granulars
(see 44 FR 45219) will also be made as standards for these
chemicals are developed or by amending existing standards.
However, the 1986 growing season restricted use effective date
will apply to any granular formulations of 6 active ingredients
that were proposed for restricted use at the same time as fonofos
granulars, if it is determined that these formulations still
warrant restriction. These 6 active ingredients are: carbofuran,
disulfoton, ethoprop, fensulfothion, phorate and terbufos.
Registrants of these active ingredients and fonofos will be
notified of compliance requirements by certified mail.
Active ingredients that have been evaluated through the
classification by regulation process tracked the procedures in
§162.11(c). Briefly that section requires that the existing
toxicity categories be used to identify "candidates" for restricted
use. The principal human effects triggers for chemicals used in
non-domestic settings are the Toxicity Category I criteria,
i.e., acute dermal LD50 200mg/kg; acute inhalation LC50 - 0.2mg/l;
acute oral LD50 50 mg/kg. Following the identification of candidates
based on these criteria, §162.11 calls for an evaluation of label
adequacy. If certain subjective criteria are met that indicate
current label language or new label language could be developed
to prevent unreasonable adverse effects, then the formulation/use
in question can remain general. Section 162.11 also requires an
evaluation of other information such as accident history,
epidemiology studies, etc. to determine if a formulation/use
15
-------
should be restricted. The Agency determined that the 20% granular
formulation failed to meet the label adequacy test for general
use as described in §162 .11(c)(3). Specifically, the Agency
determined that:
1) failure to follow directions for use and/or proper
disposal may result in serious adverse effects to
individuals through accidental ingestion, breathing
dust from open bags, or by failure to wear rubber
gloves and/or undergo proper washing [162.11(c)(3)(ii ) ].
2) failure to follow directions to not store in and
around the home or garden may result in adverse effects
for individuals contacting treated surfaces or eating
treated vegetables [162.11(c)(3)(ii)].
3) following common use practices in loading or cleaning
equipment could result in serious adverse effects to the
applicator [162.11(c)(3)(iii)].
As noted earlier in this section, the registrant of fonofos,
Stauffer Chemical Co. expressed concern over the use of acute
oral toxicity data as a basis for restricting granular formulations
The Agency's rationale for relying on acute oral data is presented
in the preamble to the proposed rule classifying fonofos for
restricted use. Specifically, the Agency was concerned with the
potential for inadvertent ingestion of granulars by users during
loading, application, equipment calibration, equipment maintenance
and cleaning, and handling of containers during disposal. The
Agency was also concerned with the possible accidental ingestion
of granulars by children, pets and farm animals during the storage
of granular formulations. The criteria followed by the Agency in
making classification decisions (§162.11(c)) provide for an extra
margin of safety in domestic use situations where children and
16
-------
pets are likely to have access to pesticides. In general the
farm environment is considered to be non-domestic, but children
living on the farm, pets, and farm animals often have access to
stored pesticides and the Agency believes that this fact should
be considered in assessing the hazard of non-domestic use pesticides.
There has been one reported case of ingestion of fonofos 20%
granulars by two children, one of whom died. In addition, several
cases of farm animals dying from ingesting stored granular
pesticides, including fonofos, have been reported.
Prior to the Agency proposing fonofos 20% granulars for
restricted use by regulation, it sought advice from USDA Cooperative
Extension Service personnel and State regulatory .officials in
States where granular formulations are widely used. They
confirmed that oral toxicity of granular formulations was a
legitimate concern in non-domectic use situations. Specif ically.-
they mentioned the importance of oral toxicity with respect to
potential hazards associated with equipment cleaning, maintenance
and product storage.
During the public comment period for the proposed regulation,
(August - October 1979), Stauffer Chemical Co. submitted comments
on several aspects of the proposed classification of fonofos 20%
granulars for restricted use. Of most concern was the use of
acute oral toxicity data as a basis for restriction. A discussion
of Stauffer's comments follow.
Stauffer stated that the use of acute oral mammalian toxi-
city as a trigger for restricted use of fonofos granular products
17
-------
is inappropriate. Stauffer noted that FIFRA "... recognizes
the general inappropriateness of the acute oral trigger in section
3(d)(l)(C)(i) by limiting the requirement of application only by
certified applicators to those cases involving a hazard from acute
dermal or inhalation toxicity. It specifically excludes use of
acute oral toxicity for classification purposes." The Agency does
not interpret 3 (d) (1 ) (C) (i ) as a prohibition against the consider-
ation of oral toxicity in classifying pesticides, but rather a
requirement that if a use/ formulation is classified restricted
solely on the basis of acute dermal and/or inhalation hazard,
limiting its use to certified applicators or individuals under
their supervision is the only restriction authorized by section
Further, Stauffer stated that the Agency "recognized the gen-
eral inappropriateness of using acute oral toxicity" in the pream-
ble to section 3 regulations, July 3, 1975, (40 FR 28257). In this
portion of the preamble, the Agency states that "if a formulation
intended for non-domestic use falls into toxicity category I based
on dermal, inhalation, skin or eye effects such formulation will
be considered a candidate for restricted use." The absence of
reference to oral toxicity in the preamble, while somewhat at odds
with 40 CFR 162 .11 (c) ( 2 ) , Classification of Previously Registered
Products, does not prohibit or limit the use of oral toxicity as a
criterion for identifying formulations/uses as candidates for
restricted use. FIFRA clearly gives the Administrator authority
to consider other relevant information in deciding which formula-
18
-------
•Lions/uses should be restricted under section 3 (d) (1) (c) (ii) .
Further, §162.11(c)(2) states "... the existing Toxicity Category
determinations shall be used to establish whether the pesticide
use(s) is a candidate for general or restricted use classification."
The acute oral toxicity as well as acute dermal, inhalation and
skin and eye effects are used to determine the toxicity category
of a formulation.
Stauffer suggests that the Agency's definition of "use" [40
CFR 162.3(oo)] places storage concerns outside the requirements
of certification. The Agency's position has been that certain
aspects of storage, but not all, are outside the scope of the
restricted-use program insofar as certification is involved. For
instance, it seems unreasonable to require those individuals in the
distribution chain from producer to retailer to be ceritifed, since
such individuals do not, except in unusual circumstances, come in
contact with the actual pesticide; further, the storage of such
pesticides in a retail establishment or warehouse would not pose
any significant risk to children or farm animals. However, once a
pesticide product is in the hands of the actual user there are sig-
nificant risks associated with the subsequent storage of pesticides,
and in this context storage is an appropriate concern for the appli-
cator certification program. In this regard, acute oral toxicity
of a formulation is a relevant factor that should be considered in
any classification determination.
Stauffer also noted that: (1) Proper use of granular Dyfonate
(fonofos) eliminates the potential for any oral ingestion exposure
19
-------
because application of the granules leaves them widely dispersed or
actually incorporated in soil, and therefore the granules are not
readily available for human, pet or livestock ingestion after use.
(2) By following clear label instructions to wear gloves and to
wash hands, arms, and face before eating or smoking, the applicator
will avoid any oral exposure during preparation for and application
of Dyfonate (fonofos) granular products. Stauffer also noted
that this fact was specifically recognized in the EPA/State
meeting held to discuss Dyfonate (fonofos) granulars where the
acute hazard was characterized as low. (3) Label instructions
also instruct the user not to store Dyfonate (fonofos) in or
around the home or with food or feed.
In response, the Agency notes that one of the basic assertions
made by Congress in passing the 1972 FIFRA amendments was that
label requirements by themselves had not been adequate to protect
the pesticide user or other persons form the adverse effects of
exposure to pesticides. The whole concept of classififcation and
the limitation classification places on restricted use products,
i.e., use by certified applicators, individuals under the supervision
of a certified applicator or other regulatory restrictions that
may be imposed by the Administrator, rests on the recognized
inadequacy in certain cases of labels and labeling' alone to
provide adequate protection for man and the environment.
The Agency has translated this intent into operational guide-
lines for classification. The manner in which the Agency measures
potential hazard is to examine both the inherent toxicity of a
20
-------
pesticide formulation and the likelihood of exposure during use.
With respect to acute oral toxicity, the Agency uses toxicity cate-
gory I, an acute oral LD50 value of 50 mg/kg or less, as a criterion
for identifying candidate formulations for restricted use.
Although this is necessarily an "arbitrary" value, in the sense
that some other threshold could have been used instead, it is one
that has been in use for many years, is the key to EPA's precaution-
ary labeling requirements, and is generally acceptable and recog-
nized as a benchmark by registrants, users, etc.
Regarding the question of exposure; the Agency believes
there is a potential for inadvertent ingestion during storage and
loading, etc., that supports restriction. Although the attendees
of the EPA/State meeting referred to by Stauffer did conclude
that the hazard to the applicator from Dyfonate (fonofos) was
low, the State participants, regulatory and Extension personnel
from States where granulars are widely used, did express overall
concern that granulars with an oral LD50 equal to 50 mg/kg or
less, toxicity category I, should be classified for restricted
use. This would include Dyfonate (fonofos) 20% granular formulations,
Stauffer also claimed that Dyfonate(fonofos) granular products
do not exceed the acute oral toxicity trigger for category I.
The registrant suggests that the rabbit is a more appropriate
test species than the rat, the test species for which the Agency
has data, because of the difficulties in administering granulars
to rats imposed by their size and because the rabbit is an equally
sensitive species. Further, Stauffer states that the extrapolated
21
-------
LD50 for all Dyfonate (fonofos) granular formulations is above
50 ing/kg in either the rat or rabbit.
Regarding Stauffer's contention that the rabbit is a more
appropriate test species than the rat, the Agency notes that the
difficulties cited by the registrant is administering granules to
rats are not apparent from the acute oral toxicity studies using
various vehicles to administer the granular formulations of
Dyfonate(fonofos) 20% granulars. These data show that the LD50
values of the 20% granular administered to female rats via a
capsule, the method purported to traumatize the rat, are identical
to the LD50 value for female rats administered powdered granules
suspended in corn oil. A similar relationship in LD50 values is
also observed in tests conducted with male and female rabbits
using capsules and a corn-oil medium although the LD50 value for
the male and female rabbit is greater that 50 mg/kg.
The data on hand also show clearly that the female rat is
consistently the most sensitive indicator of the acute oral
toxicity of fonofos, with LD values less than 50 mg/kg for the
20% formulation. Further, the rat is the preferred species for
acute oral toxicity testing (see the proposed Registration Guidelines,
43 FR 37355, August 22, 1978). The rat historically has been
used for this type of testing and the Agency's acute oral data
base is built on rat data. The introduction of data on another
species would unnecessarily complicate toxicity comparisons
between products.
The registrant's claims concerning the fact that the
22
-------
extrapolated data from the technical material show that the acute
oral LD50 for both rats and rabbits is greater that 50 mg/kg is
not persuasive since data are available on the formulated product.
Although the Agency sometimes extrapolates from technical material,
these extrapolated values would not be considered to be more
valid than the actual data on the formulated product which the
Agency used in its evaluation.
Finally, in this area the Agency has long been guided by
principles enunciated by the National Academy of Science which
has stated that, "While extrapolation of test results to humans
may not always be valid, the correlation is reasonably good for
single oral doses. Materials highly toxic to rodents generally
are highly toxic to humans. Marked variation in responses of
different species calls for the assumption that man is at least
as sensitive as the most sensitive species studies." Emphasis
added. National Academy of Science Publication 1138, Revised,
1977).
Following the submission of comments during the public
comment period, Stauffer began developing an alternative approach
to the evaluation of hazards of granular pesticides. Stauffer
suggested a "modeling" approach to hazard assessment which appears
to provide improved methods for estimating exposure from inhalation
of granular fines (small particles) and the resulting biological
responses to inspiration of small fines. Although the Agency
believes this approach may ultimately be valuable in determining
hazards for applicators it does not address the Agency's principal
23
-------
concern over potential inadvertent ingestion by children, pets
and farm animals.
Stauffer has also redesigned their 20% granular product
label with new graphics, coloring and more prominent warnings
about the potential hazard to livestock from contaminated feed.
The Agency believes that these changes make for an improved
product label, but will not reduce the risk to such a degree that
a restricted use classification is no longer needed.
Following submission and evaluation of data required by the
standard, e.g. chronic data, it may be necessary to classify
additional formulations of fonofos for restricted use.
E. CRITERIA FOR REGISTRATION UNDER THIS STANDARD
This Guidance Document covers products that contain fonofos
as a pesticide active ingredient, and the chart in the Intro-
duction describes the extent to which such products are sub-
ject to this Document. Applicants for registration of such
products must comply with all terms and conditions described
herein. This includes making a commitment to fill data gaps
on a schedule specified by the Agency. Also, applicants for
reregistration must follow the instructions contained in the
Guidance Document and complete and submit the appropriate
forms within the specified times. End-use products must be
in compliance with the label changes specified in this
Document
24
-------
F. ACCEPTABLE RANGES AND LIMITS
1. To be fully covered by this Guidance Document, manu-
facturing-use products and end-use products must contain
fonofos as the sole active ingredient. Each product proposed
for registration must be fully described with appropriate
certification of limits.
2. The Agency will consider for registration any product
whose acute toxicity category (I,11,III, or IV) is supported
by adequate acute toxicity data and labeling, including
appropriate precautionary statements.
G. REQUIRED LABELING
All manufacturing-use products and end-use products containing
fonofos must bear appropriate labeling as specified in 40 CFR
162.10. Amended labeling incorporating all label changes
specified in this Guidance Document must be submitted to the
Agency within 90 days of receipt of this Guidance Document.
1. Label .Requirements for Manufacturing-Use Products
a. Ingredient Statements
The ingredient statement for MP's must list the
active ingredient ass
fonofos: O-ethyl S-phenyl ethylphosphonodithioate
b. Use Pattern Statement
All MP's must state on the product label that they
are intended only for formulation into end-use
products for any of the use patterns listed below.
A limiting factor will be the data that support
25
-------
these use patterns. No use may be included on the
labeling where the registrant fails to agree to
comply with the data requirements in either Table
A or Table B for that use pattern.
Terrestrial, non-domestic, food uses on: asparagus,
beans (dry, lima and green), beets, broccoli,
brussels sprouts, cabbage, cauliflower, cole crops
(seed only), corn (field, sweet and pop), mint
(peppermint and spearmint), onion (bulb), peanuts,
peppers, potatoes (Irish and sweet), radishes,
sorghum (grain), strawberries, sugarbeets, sugarcane
and tomatoes.
0 Terrestrial, non-domestic, non-food use on:
ornamental turf (bluegrass, bahiagrass, Bermuda-
grass, St. Augustinegrass and zoysiagrass) and
tobacco.
0 Domestic outdoor use on: lawns, beans (snap),
beans (lima), beets, broccoli, brussels sprouts,
cabbage, cauliflower, corn, potatoes (white),
potatoes (sweet), radishes, tomatoes, and straw-
berries. "
c. Precautionary Statements
Labels for all MP products containing fonofos must
bear statements reflecting the hazards to humans
based on toxicity, environmental hazards, and
physical/chemical hazards of the compound.
0 Statement of Environmental Hazard
The statements below are required to appear on
MP products containing fonofos:
ENVIRONMENTAL HAZARDS
This pesticide is toxic to fish and wildlife.
Do not discharge into lakes, streams, ponds or
public waters unless in accordance with an NPDES
permit. For guidance contact your regional office
of the EPA.
26
-------
2. Label Requirements for End-Use Products
a. Ingredients Statement
The ingredient statement for end-use products must
list the active ingredient .as:
fonofos: 0-ethyl S-phenyl ethylphosphonodithioate
b. Use Pattern Statements
The following statements, in addition to current
label requirements, are required to appear on all
end-use products except the 2% granular product:
"Do not enter treated areas for 24 hours
after application."
"Wear gloves and shoes when handling or applying."
The following statements, in addition to current label
requirements, are required to appear on the 2%
granular product for home lawn and vegetable use:
\
"Lawns - Water material into soil immediately
after application. Do not enter treated areas
or allow children and pets on lawns for 24
hours and until grass has completely dried."
"Vegetable Gardens - Do not enter treated
areas for 24 hours after application."
"Wear gloves and shoes when handling or applying."
The following statement is required to appear on
all end-use products with directions for use on
food crops:
"Do not rotate with carrots."
c. Precautionary Statements
Labels for all end-use products containing fonofos must
bear statements reflecting the hazard to humans based
on toxicity, environmental hazards and chemical/
physical hazards. 27
-------
0 Statement of Human Hazard.
Fonofos is registered in toxicity categories
I,II, and III. The required precautionary
language is found in 40 CFR 162.10.
Statement of Environmental Hazard.
The following statements are required to appear
on all end-use products containing fonofos:
ENVIRONMENTAL HAZARDS
This pesticide is toxic to fish and wildlife.
Birds feeding in treated areas may be killed.
Remove or cover granules if spills occur.
Runoff from treated areas may be hazardous to
fish in neighboring areas. Do not apply directly
to water or wetlands. Do not contaminate water
by cleaning of equipment or disposal of waste.
For guidance contact your regional office of the
EPA.
H. -TOLERANCE REASSESSMENT
Tolerances are established for residues of the insecticide
0-ethyl S-phenyl ethylphosphonodithioate, including its oxygen
analog O-ethyl S-phenyl ethylphosphonothioate*, in or on raw
agricultural commodities as follows (40 CFR 180.221):
0.5 part per million in or on asparagus.
0.1 part per million (negligible residue) in or on bean
forage, bean vine hay, fresh corn including sweet corn
(kernels plus cob with husk removed), corn grain (in-
cluding popcorn), corn forage or fodder (including
sweet corn, field corn, and popcorn), fruiting vege-
* The 1983 CFR citation reads S-ethyl S-phenyl28
ethylphosphonothiolate and should be corrected.
-------
tables, leafy vegetables, mint (peppermint, spearmint,
peppermint hay, and spearmint hay), pea forage, pea
vine hay, peanuts, peanut forage, peanut hay, peanut
hulls, root crop vegetables, seed and pod vegetables,
sorghum (grain, fodder, and forage), soybean forage,
soybean hay, strawberries, sugar beet tops, and
sugarcane.
Canada has established tolerances for residues in corn, onions,
potatoes and sugar beets. These tolerances are at the same
level as the U.S. tolerances for these crops. A pending
petition in the Agency to increase the tolerance for residues
in potatoes (if established at 0.5 ppm) will result incompatibility
between the U.S. and Canadian tolerances. There is no listing
for this pesticide by Mexico or the Codex Alimentarius.
The nature of the residue of fonofos in plants is adequately
understood, but there are no data on food-animal metabolites.
Poultry and ruminant metabolism studies, in addition to a
poultry feeding study and a ruminant feeding study, are
required. There are no tolerances for meat, milk, poultry,
eggs and processed commodities. However, there is a possibility
of carry-over of residues from treated crop plants fed to
animals. If residues occur, additional tolerances and approved
analytical methods will be required.
The existing residue data are inadequate to support reassess-
ment of present tolerances for the major uses on corn, peanuts,
29
-------
sugarbeets, potatoes (Irish), sugarcane, and tobacco, nor for
several minor crops. No new crop groupings (48 FR 29855,
June 29, 1983) can be established for the categories Root
and Tuber Vegetables; Leaves of Root and Tuber Vegetables;
Bulb Vegetables; Legume Vegetables (Succulent or Dried);
Foliage of Legume Vegetables; Fruiting Vegetables (Except
Curcurbits); Small Fruits and Berries; Cereal Grains; and
Forage, Fodder, and Straw of Cereal Grains. However, the new
crop grouping, Brassica (Cole) Leafy Vegetables, can be estab-
lished at this time.
No change in the tolerance expression for fonofos and its
oxygen analog (oxon) are required at this time. A tolerance
reassessment may become neccessary once data gaps are filled.
Based on the presently established tolerances, the Theoretical
Maximum Residue Concentration (TMRC) from residues of fonofos
and its oxon in the human diet is calculated to be 0.0418
mg/day from a 1.5 kg food diet for a 60 kg person. The
Acceptable Daily Intake (ADI) for fonofos and its oxon is
0.002 mg/kg/day- This is based on a two-year dog feeding
study with a No Observable Effect Level (NOEL) of 8 ppm and
a safety factor of 100. The Maximum Permissible Intake (MPI)
is 0.120 mg/day/60 kg individual. Thus, the percentage of the
30
-------
ADI utilized by the established tolerance is 34.84%. This
would be increased to 41.63% under a 0.2 ppm potato tolerance,
and 61.98% if a 0.5 ppm potato tolerance is established.
Corrections to 40 CFR 180.221 will be taken as follows:
0 The tolerances under the old crop group "Root Crop
Vegetables" will be converted to individual tolerances:
Beets, Table; Onions; Potatoes; Radishes; Sugar Beets;
Sweet Potatoes; and Turnips.
0 The tolerances under the old crop group "Leafy Vegetables"
will be converted to individual tolerances: Beets, Table
(leaves); Radishes (Tops); and Sugar Beet Tops.
0 The tolerances under the old crop group "Seed and Pod
Vegetables" will be converted to individual tolerances:
Beans; Peas; and Soybeans.
0 The tolerances under the old crop group "Fruiting Vege-
tables" will be converted to individual tolerances:
Peppers; and Tomatoes.
0 A new group tolerance for "Brassica (Cole) Leafy Vegetables"
will be established.
0 The individual tolerances previously established will be
maintained.
0 The chemical designation for the oxygen analog of fonofos
will be corrected to read:
0-ethyl S-phenyl ethylphosphonothioate
31
-------
Index of Currently Acceptable Uses
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE*
TYPE PESTICIDE; Insecticide
FORMULATIONS; G (2%, 5%, 10%, 15%, 20%); EC (1 Ib/gal, 4 Ib/gal)
GENERAL WARNINGS AND LIMITATIONS;
Definition of Terms;
Claims for pest control limited to suppression of population are
indicated by parenthesized pest name.
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
AGRICULTURAL CROPS
General Warnings and Limitations: Do not enter treated areas for 24 hours
after application. For home vegetable uses (2 percent granular formula-
tion) wear gloves and shoes when handling or applying and water material
into soil immediately after application. Do not rotate with carrots.
For preplant broadcast soil application, incorporate into the top 2 to 3
inches of soil unless otherwise specified. For emulsifiable concentrate
formulations, apply in 20 to 50 gallons of water per acre by tractor
mounted spray equipment or larger custom applicator type vehicles. Remove
or cover granulues if spills occur.
Asparagus 0.5 ppm
30 day preharvest interval through
10 pounds per acre for broadcast
soil application.
Garden symphylan 3-10 Ib/A Use limited to CA.
(5-10% G) Broadcast soil application. Incor-
porate into the soil with cultiva-
tor.
*fonophos
Issued: 3-22-82 III-041701-1
Provisional Update: 3-30-84
32
-------
EPA Index to Pesticide Chemicals
/15001AA
/15003AA
Site and Pest
Beans, Dry
Beans, Green
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.1 ppm (bean forage, bean vine hay)
0.1 ppm (seed and pod vegetables)
Broadcast soil application (pre-
plant) through 4 pounds per acre.
Emulsifiable concentrate formulation
may be tank mixed with S-ethyl di-
propylthiocarbamate in fluid ferti-
lizer or water.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
are RESTRICTED USE PESTICIDES.
IJDAABA
INAVAAA
IOACAHA
Garden symphylan
Wireworms
Seedcorn maggot
IJDAABA
INAVAAA
Garden symphylan
Wireworms
2 Ib/A Preplant broadcast soil application.
(10% G) Incorporate into the soil by disc-
(4 Ib/gal EC) ing.
4 Ib/A
(10% G)
(4 Ib/gal EC)
2-4 Ib/A Use limited to Northwestern states.
(10% G) Preplant broadcast soil application.
(4 Ib/gal EC) Incorporate into the top 2 to 4
inches of soil. Apply the higher
rate where population pressure is
severe.
4 Ib/A Use limited to Northeastern states.
(4 Ib/gal EC) Preplant broadcast soil application.
Incorporate into the top 2 to 4
inches of soil.
0.08 oz/
100 sq.ft
(2% G)
0.16 oz/
100 sq.ft
(2% G)
Broadcast soil application prior to
or at planting. Apply with a fer-
tilizer spreader or by shaking from
the canister. Incorporate with a
rake or power tiller.
Issued: 3-22-82
III-041701-2
33
-------
I25AA
Site and Pest
Beans, Lima
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.1 ppm (bean forage, bean vine hay)
0.1 ppm (seed and pod vegetables)
Broadcast soil application (pre-
plant) through 4 pounds per acre.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
are RESTRICTED USE PESTICIDES.
lABA
Garden symphylan
VAAA
Wireworms
D02AA
Beets
.CADA
AABA
Cabbage maggot
Garden symphylan
2 Ib/A Preplant broadcast soil application.
(10% G) Incorporate into the soil by disc-
(4 Ib/gal EC) ing.
0.08 oz/ Broadcast soil application prior to
100 sq.ft or at planting. Apply with a fer-
(2% G) tilizer spreader or by shaking from
the canister. Incorporate with a
rake or power tiller.
4 Ib/A Use limited to CA.
(4 Ib/gal EC) Preplant broadcast soil application.
Incorporate into the soil by disc-
ing.
0.1 ppm (root crop vegetables,
leafy vegetables)
Broadcast soil application (pre-
plant) through 2 pounds per acre.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
are RESTRICTED USE PESTICIDES.
2 Ib/A Preplant broadcast soil application.
(10% G) Incorporate into the soil by disc-
(4 Ib/gal EC) ing.
0.08 oz/ Broadcast soil application prior to
100 sq.ft or at planting. Apply with a fer-
(2% G) tilizer spreader or by shaking from
the canister. Incorporate with a
rake or power tiller.
Issued: 3-22-82
III-041701-3
34
-------
/13005AA
/13006AA
/13007AA
/13008AA
Site and Pest
Broccoli
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
Brussels Sprouts
Cabbage
Cauliflower
IJDAABA
Garden symphylan
IOACADA
Cabbage maggot
0.1 ppm (leafy vegetables)
Broadcast soil application (pre-
plant or at time of planting)
through 4 pounds per acre.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
and 20 percent granular formulations
are RESTRICTED USE PESTICIDES.
2 Ib/A Broadcast soil application prior to
(10% G) or at time of seeding or transplant-
(4 Ib/gal EC) ing. Incorporate into the soil by
discing.
0.08 oz/ Broadcast soil application prior to
100 sq=ft or at time of seeding or transplant-
(2% G) ing. Incorporate with a rake or
power tiller.
4 Ib/A Broadcast soil application prior to
(15-20% G) or at time of seeding or transplant-
ing. Incorporate into the soil by
discing. Not recommended in the
Northwestern United States.
1-2 Ib/A Use limited to Northeastern states.
[200-400 Soil drench to transplants immedi-
gal/AJ ately after transplanting. Apply by
(4 Ib/gal EC) ground equipment with drop nozzles
to direct spray to base of plants.
/13004BA
IOACADA
Cole Crops (seed crop)
Cabbage maggot
2 Ib/A
G)
0.1 ppm (leafy vegetables)
Broadcast soil application to seed
crop prior to or at time of seeding
or transplanting. Incorporate into
the soil by discing.
Issued: 3-22-82
III-041701-4
35
-------
EPA Index to Pesticide Chemicals
I06AA
I04AA
I05AA
Site and Pest
Corn, Field
Corn, Pop
Corn, Sweet
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.1 ppm fresh corn including sweet
corn (kernels plus cob with husks
removed), corn grain (including pop-
corn) , corn forage or fodder (in-
cluding sweet corn, field corn, and
popcorn)
45 day preharvest and 30 day pre-
grazing interval through 1 pound per
acre for foliar application and
postemergent soil application at
cultivation (band).
Broadcast soil application (pre-
plant) through 4 pounds per acre.
Banded soil application (at plant-
ing) through 2 pounds per acre.
Unless otherwise specified, row ap-
plication per acre rates are based
on 38 to 40 inch row spacing.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
and 20 percent granular formulations
are RESTRICTED USE PESTICIDES.
GALA
VAAA
(Black cutworm)
(Wireworms)
MBOA
Lesser cornstalk
borer
1 Ib/A Soil application at planting (band).
or Apply a 6 to 8 inch band. Incorpo-
1.2 oz/ rate into the top 0.5 to 1 inch of
1,000 ft row soil either by applying ahead of
(10-20% G) press wheels or by dragging a short
length of chain behind the press
2 Ib/A wheels. Do not place in direct con-
or tact with the seed.
2.4 oz/
1,000 ft row
(10-20% G)
MBLA
MBMA
iMBOA
Northern corn root- 0.75-1 Ib/A
worm or
Southern corn root- 0.9-1.2 oz/
worm 1,000 ft row
Western corn root- (10-20% G)
worm or
0.75-1 Ib/A
(5% G)
(4 Ib/gal EC)
LCAHA
Seedcorn maggot
0.75-1 Ib/A
or
O.y-1.2 oz/
1,000 ft row
(10-20% G)
Issued: 3-22-82
III-041701-5
36
-------
Site and Pest
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
Corn, Field cluster (continued)
INAKABA
Seedcorn beetle
0.75-1 Ib/A Use limited to Central and Midwest-
or ern corn growing areas.
0.9-1.2 oz/ Soil application at planting (band).
1,000 ft row Apply a 6 to 8 inch band. Incorpo-
(10-20% G) rate into the top 0.5 to 1 inch of
soil either by applying ahead of
press wheels or by dragging a short
length of chain begind the press
wheels. Do not place in direct con-
tact with the seed.
ITBMCCA
ITBMAYA
European corn borer
Southwestern corn
borer
IJDAABA
INAVAAA
INAMBLA
INAMBMA
INAMBOA
INAKABA
IOACAHA
Garden symphylan
Wireworms
1 Ib/A
[minimum 30
inch row
spacing]
(10-20% G)
0.08 oz/
100 sq.ft
(2% G)
0.16 oz/
100 sq.ft
(2% G)
Foliar application„ Band or broad-
cast over the corn so the granules
fall into the whorl. Broadcast ap-
plication may be applied by air-
craft. Apply 6 to 8 inch bands over
corn rows by ground equipment. For
European corn borer, apply when 50
percent of the plants show first
generation borer feeding. For sec-
ond generation, apply when counts
show 100 egg masses per 100 plants.
For southwestern corn borer, apply
when newly hatched larvae first ap-
pear and repeat as needed to control
later generations.
Broadcast soil application prior to
or at planting. Apply with a fer-
tilizer spreader or by shaking from
the canister. Incorporate with a
rake or power tiller.
Northern corn root- 0.75-1 Ib/A
worm or
Southern corn root- 0.9-1.2 oz/
worm
Western corn root-
worm
Seedcorn beetle
Seedcorn maggot
Postemergent soil application at
cultivation (band). Apply a 6 to 8
inch band over the corn rows. Cover
1,000 ft row treated band with 2 to 3 inches of
soil by making application ahead of
disc hillers or cultivation equip-
ment. Apply in May or June at first
sign of larval activity.
(10-20% G)
Issued: 3-22-82
III-041701-6
37
-------
EPA Index to Pesticide Chemicals
Site and Pest
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
MBLA
MBOA
Corn, Field cluster (continued)
Northern corn root- 1 lb/5-20 gal Use limited to Northcentral and Mid-
fluid fer- western corn growing areas.
tilizer/A Soil application at planting (band
[40 inch row (split boot)). Apply subsurface
spacing] split bands on each side of the corn
(4 Ib/gal EC) row 1.25 to 1.5 inches to each side
of the seed and 1 to, 2 inches deep.
Do not place in direct contact with
the seed.
worm
Western corn root-
worm
AABA
MBLA
MBMA
iMBOA
ICALA
LVAAA
Garden symphylan
5005AA
WAAA
2 Ib/A
(5-20% G)
(4 Ib/gal EC)
Northern corn root- 3-4 lb/A
worm (4 Ib/gal EC)
Southern corn root- or
worm 4 lb/A
Western corn root- (10-20% G)
worm
(Black cutworm)
Wireworms
Maize billbug
(Corn, Sweet)
Wireworms
4 lb/A
(4 Ib/gal EC)
4 lb/A
(5-20% G)
(4 Ib/gal EC)
4 lb/A
(10-20% G)
Preplant broadcast soil application.
Incorporate into the soil by disc-
ing. May be tank mixed with atra-
zine, 2-[[4-chloro-6-(ethylamino)-s-
triazin-2-yl]amino]-2-methylpropio-
nitrile, S-ethyl diisobutylthio-
carbamate (Sutan +), S-ethyl dipro-
pylthiocarbamate. Fluid fertilizers
or water may be used as a carrier.
Do not tank mix with S-ethyl dipro-
pylthiocarbamate on sweet corn or
popcorn.
Use limited to Southeastern states.
Preplant broadcast soil application.
Incorporate into the soil by disc-
ing.
2.2 oz/ Use limited to FL muck soils.
1,000 ft row Soil application at planting
[36 inch row (band). Apply a 2 inch band over
spacing] the furrow. Do not place in direct
(10-20% G) contact with the seed.
Issued: 3-22-82
III-041701-7
38
-------
Site and Pest
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
/28012AA
Mint (Peppermint, Spearmint)
IJDAABA
Garden symphylan
/14011AA
Onion, Bulb
IOACACA
Onion maggot
0.1 ppm mint (peppermint, spearmint,
peppermint hay, and spearmint hay)
Broadcast soil application (pre-
plant or established plantings)
through 2 pounds per acre.
Do not apply terbacil for a minimum
of 3 weeks before or after applica-
tion.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
are RESTRICTED USE PESTICIDES.
2 Ib/A Preplant broadcast soil application.
(10% G) Incorporate into the soil by disc-
(4 Ib/gal EC) ing.
Broadcast soil application to estab-
lished plantings. Apply prior to
spring growth.
0.1 (root crop vegetables)
In furrow soil application at plant-
ing through 0.6 ounce per 1,000
foot row with 20 inch row spacing.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
are RESTRICTED USE PESTICIDES.
°-6 °z/ Soil application at planting (in
1,000 ft row seed furrow). May be used on all
(5% G) soil types.
°-6 oz/ Soil application at planting (in
1,000 ft row seed furrow). Use on organic soils
(10% G) only (soils containing 10 percent or
(4 Ib/gal EC) more organic matter).
Issued: 3-22-82
III-041701-8
39
-------
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
L5AA Peanuts 0.1 ppm (peanuts, peanut forage,
peanut hay, peanut hulls)
Banded soil application (after peg-
ging) through 2 pounds per acre with
36 inch row spacing.
Broadcast soil application (after
pegging) through 4 pounds per acre.
For soil applications after pegging,
apply up to 30 days after pegging
begins. All 20 percent granular
formulations are RESTRICTED USE
PESTICIDES.
1BOA Lesser cornstalk 2 Ib/A Use limited to Southeastern states.
borer [36 inch row Soil application after pegging
spacing] (band). Apply an 18 inch band over
(10-20% G) rows at first sign of infestation.
4 Ib/A Use limited to Southeastern states.
(10% G) Broadcast soil application after
pegging. May be applied by air-
craft. Apply at first sign of in-
festation.
fflMA Southern corn root- 2 Ib/A Use limited to Southeastern states.
worm [36 inch row Soil application at pegging (band).
spacing] Apply an 18 inch band over rows.
(5-20% G)
IADA Burrower bug 1-2 Ib/A Use limited to Southwestern states.
[36 inch row Soil application after pegging
spacing] (band). Apply 18 inch band over
(10% G) rows.
MBOA Lesser cornstalk 2 Ib/A
borer [36 inch row
MBMA Southern corn root- spacing]
worm (10% G)
MBOA Lesser cornstalk 1-1.4 Ib/A Use limited to Southwestern states.
borer [minimum 32 Soil application after pegging
inch row (band). Apply 14 inch band over
spacing] rows.
(10% G)
IADA Burrower bug 2 Ib/A Use limited to TX.
(10% G) Broadcast soil application. Incor-
porate into the soil with 1 to 2
inches of water.
Issued: 3-22-82 III-041701-9
-------
/28017AA
Site and Pest
Peppers
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.1 ppm (fruiting vegetables)
Broadcast soil application (pre-
plant) through 4 pounds per acre.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
are RESTRICTED USE PESTICIDES.
IJDAABA
INAVAAA
/14013AA
Garden symphylan
Wireworms
Potato, Irish
IJDAABA
INAVAAA
INAVAAA
Garden symphylan
Wireworms
Wireworms
2 Ib/A Preplant broadcast soil application.
(4 Ib/gal EC) Incorporate into the soil by disc-
ing.
4 Ib/A
(4 Ib/gal EC)
0.1 ppm (root crop vegetables)
Broadcast soil application (pre-
plant) through 4 pounds per acre.
Banded soil application (at plant-
ing) through 2 pounds per acre.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
are RESTRICTED USE PESTICIDES.
2 Ib/A Preplant broadcast soil application.
(10% G) Incorporate into the soil by disc-
(4 Ib/gal EC) ing. May be tank mixed with 2-ethyl
dipropylthiocarbamate in Northern,
4 Ib/A Western, and Pacific Northwest re-
(5-10% G) gions.
(4 Ib/gal EC)
2 Ib/A Use limited to the Pacific Northwest
[36 inch row states.
spacing] Soil application at planting (band).
(10% G) Apply subsurface bands 3 to 4 inches
from and 2 inches below the seed
pieces.
2 Ib/A use limited to Northwestern states.
[36 inch row Soil application at planting (band).
spacing] Apply in liquid fertilizer. Apply
(4 Ib/gal EC) through fluid fertilizer shank im-
mediately ahead of the planter. Set
shank to run 8 to 10 inches deep.
Issued: 3-22-82
111-041701-10
41
-------
Site and Pest
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
Potato, Irish (continued)
ABA
'AAA
)14AA
Garden symphylan
Wireworms
Radish
:ADA
Cabbage maggot
Garden symphylan
019AA
S or ghum, Grain
iCDKA
iCDNA
Corn leaf aphid
Greenbug
0.08 oz/
100 sq.ft
(2% G)
0.16 oz/
100 sq.ft
(2% G)
2 Ib/A
(5-10% G)
0.08 oz/
100 sq.ft
(2% G)
Broadcast soil application prior to
or at planting. Apply with a fer-
tilizer spreader or by shaking from
the canister. Incorporate with a
rake or power tiller.
0.1 ppm (root crop vegetables)
Broadcast soil application (preplant
or at time of planting) through 2
pounds per acre.
Broadcast soil application prior to
or at time of planting. Incorporate
into the soil by discing.
Broadcast soil application prior to
or at planting. Apply with a fer-
tilizer spreader or by shaking from
the canister. Incorporate with a
rake or power tiller.
0.1 ppm (sorghum, grain, fodder and
forage)
14 day preharvest or pregrazing in-
terval through 1 pound per acre.
Do not make more than 2 applications
per crop.
Emulsifiable concentrates 44 percent
and greater <4 pounds per gallon)
are RESTRICTED USE PESTICIDES.
0.75 Ib/A Use limited to TX.
(10-15% G) Foliar application to irrigated
sorghum. Apply over the top by
aircraft.
0.75-1 Ib/A Foliar application. Apply over the
[5-30 gal/A] top. May be applied by aircraft.
(4 Ib/gal EC)
Issued: 3-22-82
III-041701-ll
42
-------
EPA Index to Pesticide Chemicals
/01016AA
Site and Pest
Strawberry
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.1 ppm
Broadcast soil application (pre-
plant) through 2 pounds per acre.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
are RESTRICTED USE PESTICIDES.
IJDAABA
Garden symphylan
/28020AA
Sugar Beets
2 Ib/A Preplant broadcast soil application.
(10% G) Incorporate into the soil by disc-
(4 Ib/gal EC) ing.
0.08 oz/ Broadcast soil application prior to
100 sq.ft or at planting. Apply with a fer-
(2% G) tilizer spreader or by shaking from
the canister. Incorporate with a
rake or power tiller.
0.1 ppm (sugar beet tops, root crop
vegetables)
Banded soil application (at planting
time) through 1.5 pounds per acre.
Broadcast soil application (pre-
plant) through 4 pounds per acre.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
and 20 percent granular formulations
are RESTRICTED USE PESTICIDES.
IOAXACA
Sugarbeet root
maggot
1-1.5 Ib/A Use limited to CO and Northwest
[.minimum 22 sugar beet growing areas.
inch row
spacing]
(10-20% G)
1 oz/
1,000 sq.ft
(10% G)
Soil application at planting (band).
Apply 7 inch band over rows and in-
corporate lightly into the soil.
Do not place in direct contact with
the seed.
Use limited to the Big Horn Basin of
WY.
Subsurface soil application at
planting (band). Apply subsurface
band 2 inches from seed furrow and 2
inches below the soil surface on the
irrigated side of the row. Do not
place in direct contact with the
seed.
Issued: 3-22-82
111-041701-12
43
-------
EPA Index to Pesticide Chemicals
Site and Pest
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Fprmulation(s)
Sugar Beets (continued)
IABA
7AAA
003AA
Garden symphylan
Wireworms
Sugarcane
PAAA
White grubs
,VAAA
Wireworms
2 Ib/A Preplant broadcast soil application.
(10% G) Incorporate into the soil by disc-
(4 Ib/gal EC) ing.
4 Ib/A
(5-10% G)
(4 Ib/gal EC)
0.1 ppm
Banded soil application (at time of
planting) through 7.36 ounces per
1,000 foot row with 60 inch row
spacing.
Banded soil application (postemer-
gent) through 10.88 ounces per 1,000
foot row with 60 inch row spacing.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
and 20 percent granular formulations
are RESTRICTED USE PESTICIDES.
7.2-10.88 oz/ Use limited to Southwestern states.
1,000 ft row Postemergent soil application
(15-20% G) (band). Apply 20 inch band over top
of the cane row. Lightly incorpo-
rate as close to the plants as pos-
sible. Irrigate after application.
Apply at and up to 2 weeks following
peak adult flight.
5.44-7.36 oz/ Soil application at planting (band).
1,000 ft row Apply 14 inch band over tops of seed
(10% G) pieces immediately ahead of covering
(4 Ib/gal EC) discs. Apply high rate in areas
outside of FL.
Issued: 3-22-82
III-0417Q1-13
-------
/14018AA
Site and Pest
Sweet Potato
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.1 ppm (root crop vegetables)
Broadcast soil application (at
planting time or root swelling)
through 4 pounds per acre.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
and 20 percent granular formulations
are RESTRICTED USE PESTICIDES.
INAMADC
INAMADC
INAVAAA
Flea beetles
(larvae) (includ-
ing elongate flea
beetle, pale-
striped flea
beetle, sweet-
potato flea
beetle, three-
spotted flea
beetle)
Flea beetles
(larvae) (includ-
ing elongate flea
beetle, pale-
striped flea
beetle, sweet-
potato flea
beetle, three-
spotted flea
beetle)
Wireworms
INAVAAA
Wireworms
4 Ib/A Broadcast soil application at plant-
(4 Ib/gal EC) ing. Incorporate into the soil by
discing.
4 Ib/A Use limited to Southeastern states.
(10-20% G) Broadcast soil application at plant-
ing. Incorporate into the soil by
discing .
3 Ib/A Use limited to Southeastern states.
(10-20% G) Broadcast soil application at root
swelling. Apply over the top.
4 Ib/A Broadcast soil application at plant-
(5-20% G) ing or root swelling. Apply at
planting and incorporate into the
soil by discing, or over the top at
root swelling.
2 Ib/A
G)
Use limited to Southeastern states.
Preplant broadcast soil application.
Incorporate into the soil by disc-
ing.
0.16 oz/ Broadcast soil application prior to
100 sq.ft or at planting. Apply with a fer-
(2% G) tilizer spreader or by shaking from
the canister. Incorporate with a
rake or power tiller.
Issued: 3-22-82
111-041701-14
45
-------
103AA
106AA
/AAA
Site and Pest
Tobacco
Wireworms
306AA
/AM
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Formulation(s)
N.F.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
are RESTRICTED USE PESTICIDES.
1-2 Ib/A Preplant broadcast soil application.
(5-10% G) Incorporate into the soil by disc-
(4 Ib/gal EC) ing. Apply prior to bedding and
planting.
(Tobacco, Flue Cured)
Wireworms 1 Ib/A Preplant broadcast soil application.
(4 Ib/gal EC) Apply prior to bedding and planting.
Tank mix with S-propyl butylethyl-
thiocarbamate.
1 Ib/A Preplant broadcast soil application.
(1 Ib/gal EC) Apply prior to bedding and planting.
Formulated with S-propyl butylethyl-
thiocarbamate.
005AA
Tomato
lAABA
Garden symphylan
0.1 ppm (fruiting vegetables)
Broadcast soil application (pre-
plant) through 2 pounds per acre.
Emulsifiable concentrates 44 percent
and greater (4 pounds per gallon)
are RESTRICTED USE PESTICIDES.
2 Ib/A Preplant broadcast soil application.
(10% G) Incorporate into the soil by disc-
(4 Ib/gal EC) ing.
0.08 oz/ Broadcast soil application prior to
100 sq.ft or at planting. Apply with a fer-
(2% G) tilizer spreader or by shaking from
the canister. Incorporate with a
rake or power tiller.
Issued: 3-22-82
111-041701-15
46
-------
Site and Pest
ORNAMENTALS
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Dosages and Tolerance, Use, Limitations
Fonnulation(s)
(Lawns and Turf (including ground covers))
/330L5AA Bahiagrass
/33017AA Bermudagrass
/33019AA Bluegrass
/33050AA St. Augustinegrass
/33056AA Zoysia Grass
IQALAEA Chinch bug
IMDAAAA Earwigs
ITBMABA Sod webworms
5.6-7.5 oz/
5,000 sq.ft
(2-5% G)
Do not water the lawn prior to
treatment. Do not allow children
and pets on lawns for 24 hours and
until grass has completely dried.
Gloves and shoes must be worn during
handling and application.
Application to established lawns and
turf. Use the higher rate for heavy
infestations. Apply with a lawn
fertilizer spreader when pests first
appear and repeat as needed. Water
granules into the root zone for 10
to 15 minutes immediately after ap-
plication. For chinch bugs in
Southern states and for earwigs and
sod webworms in the Southeast.
9001500
AAAAAAA
AERIAL, MOTHPROOFING AND TANK MIX APPLICATIONS
Aerial Application
Refer to
AGRICULTURAL CROPS
Corn (Field), Corn (Pop), Corn
(Sweet), Peanuts, Sorghum (Grain)
9900300
AAAAAAA
Tank Mix
Refer to
AGRICULTURAL CROPS
Beans (Dry), Beans (Green), Corn
(Field), Corn (Pop), Corn (Sweet),
Potato (Irish), Tobacco (Flue Cured)
Issued: 3-22-82
111-041701-16
47
-------
EPA Index to Pesticide Chemicals
0-ETHYL S-PHENYL ETHYLPHOSPHONODITHIOATE
Listing of Registered Pesticide Products by Formulation
2% granular
o-ethyl s-phenyl ethylphosphonodithioate (041701)
000476-02120
5% granular
o-ethyl s-phenyl ethylphosphonodithioate (041701)
000476-01994 000476-02121
10% granular
o-ethyl s-phenyl ethylphosphonodithioate (041701)
000476-01995
15% granular
o-ethyl s-phenyl ethylphosphonodithioate (041701)
000476-02030
20% granular
o-ethyl s-phenyl ethylphosphonodithioate (041701)
000476-02028
1 Ib/gal emulsifiable concentrate
o-ethyl s-phenyl ethylphosphonodithioate (041701), S-propyl butylethyl-
thiocarbamate (041403) plus xylene range aromatic solvent (086803)
000476-02071
4 Ib/gal emulsifiable concentrate
o-ethyl s-phenyl ethylphosphonodithioate (041701)
000476-02190
o-ethyl s-phenyl ethylphosphonodithioate (041701) plus petroleum distil-
late (063503)
000476-02056 000476-02134
!99 State Label Registrations
CA Reg. No.
000476-04093
OR Reg. No.
000476-04094 000483-04590 000483-04591 000483-04593
001871-09820 001871-09821 035503-09485
TX Reg. No.
006735-04811
WA Reg. No.
007404-06537
WY Reg. No.
000476-04095
Issued: 3-22-82 111-041701-17
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
y
Data Requirement Composition
§158.120 Product Chemistry
Product Identity:
61-1 - Identity of Ingredients TGAI (95+ 2%)
61-2 - Statement of Composition TGAI
6 1-3 - Discussion of Formation of TGAI
Unintentional Ingredients
Analysis and Certification of product
Ingredients
62-1 - Preliminary Analysis TGAI
62-2 - Certification of Limits TGAI
62-3 - Analytical Methods for TGAI
Enforcement of Limits
Physical and Chemical Characteristics
Does EPA Have Data
To Satisfy This
Requirement? (Yes, Bibliographic
No or Partially) Citation
Yes 00059851*
Partially 00059851*
Partially 00059851*
Partially 00059851*
No 00059851*
Yes GS-0 105-004
Must Additional
Data Be Submitted
Under FIFRA Sectioi
3(c)(2)(B)?2/
No
Yes3/
YesV
Yes5/
Yes6/
No
63-2 - Color
63-3 - Physical State
63-4 - Odor
TGAI
TGAI
TGAI
Yes
Yes
Yes
00059851*
00059851*
00059851*
No
No
No
* Data submitted by Stauffer Chemical Co. These data may be compensable.
49
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Data Requirement
§158.120
63-5 -
63-6 -
63-7 -
63- 8 -
63- 9 -
63-10 -
63-11 -
Product Chemistry
( continued )
Melting Point
Boiling Point
Density, Bulk Density, or
Specific Gravity
Solubility
Vapor Pressure
Dissociation constant
Octanol/water partition
I/
Composition
TGAI
TGAI
TGAI
TGAI OR PAI
PAI
PAI
PAI
Does EPA Have Data
To Satisfy This
Requirement? ( Yes ,
No or partially)
Yes
Yes
Yes
Yes
Yes
Not Applicable
partially
Bi bliographic
Citation
00059851*
00059851*
00059851*
00059851*
00059851*
00059851*
Must Additional
Data Be Submitted
Under FIFRA Sectio
3(c)(2)(B)?2/
No
No
No
No
No
Yes7/
coefficient
63-12 - pH
63-13 - Stability
Other Requirements;
64- 1 - Suimittal of samples
TGAI
TGAI
Choice
Yes
Yes
00059851*
00059851*
No
No
*Data submitted by Stauffer Chemical Co. These data may be compensable.
50
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOPOS
§158.120 Product Chemistry
(continued)
_!/ Composition: TGAI = Technical grade of the active ingredient; PAI = Pure active ingredient; Choice = Choice of
several test substances determined on a case-by-case basis.
2/ Data must be submitted no later than March 31, 1987.
3/ A statement is needed to indicate the procedure of the manufacturing process that is now in actual use.
4/ If the alternate procedure is in use, the possibility of introducing nitrosamine into the technical chemical
should be discussed.
5/ A description of the method(s) and validating data used to obtain the preliminary analysis is needed. Five or
more representative samples should be analyzed.
&/ Certification of limits is required for end-use products, also.
2/ Unless the registrant can relate the submitted solvent partition p-values to the octanol/water partition co-
efficient, data for the octanol/water partition coefficient will be needed.
51
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Data Requirements
Does EPA Have Data
To Satisfy This
J/ Requirement? (Yes,
Composition No, or Partially)
Bi bliographic
Citation
Must Additional
Data Be Sutmitted
Under FIFRA Section
3(c)(2)(B)?2/
§158.125 Residue Chemistry
171-4 - Nature of Residue (Metabolism)
- Plants
PAIRA
Yes
00052067*
GS-0105-005
GS-0105-006
GS-0105-007
GS-0105-008
05018141
- Livestock
PAIRA and plant
metabolites
Partially
GS-0105-009
00090878*
00090875*
00090876*
GS-0105-010
GS-0105-011
Yes3/24/
171-4 - Residue Analytical Method
- Plant residues TGAI and metabolites Yes
- Animal residues
TGAI and metabolites
Yes
* Data submitted by Stauffer chemical Co. These data may be compensable.
GS-0105-012
GS-0105-013
GS-0105-015
GS-0105-004
GS-0105-012
GS-0105-013
GS-0105-015
GS-0105-004
52
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Data Requirement
Does EPA Have Data
To Satisfy This
J/ Requirement? (Yes,
Composition No or partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
171-4 - Storage Stability Data
PAI
Yes
GS-0105-013
GS-0105-015
No^f
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
Root and Tuber Vegetables
0 Beets,Table (roots)
0 Potatoes (Irish)
0 Radishes (roots)
0 Sugar Beets
0 Sweet Potatoes
0 Turnips (roots))
Leaves of Root and Tuber
Vegetables
0 Beets, Table (leaves)
0 Radishes (tops)
0 Sugar Beets (tops)
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
Yes GS-0105-016
Partially GS-0 105-0 13
GS-0105-016
No
No
No
No
Yes GS-0105-016
No
No GS-0105-016
No
YesV
YesV
YesV
Yes6/
YesV
No
YesV
YesV
53
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
V
Data Requirement Composition
Bulb Vegetables
0 Onions TEP
Brassica (Cole) Leafy Vegetables
0 Broccoli TEP
0 Brussels Sprouts TEP
0 Cabbage TEP
0 Cauliflower TEP
Legume Vegetables (Succulent or
Dried)
0 Beans (green, dry, lima) TEP
0 Soybeans TEP
0 Peas TEP
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Yes
Yes
Yes
Yes
Yes
Yes
Yes
No
Must Additional
Data Be Submitted
Bibliographic Under FIFRA Sectio
Citation 3(c) (2) (B)?2/
GS-0 105-016 No
GS-0 105-0 17* No
GS-0 105-0 17* No
GS-0105-017* No
GS-0 105-0 17* No
GS-0105-017* No
GS-0 105-0 13 No
NO9/
* Data submitted by Stauffer chemical Co. These data may be compensable.
54
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Data Requirement
Does EPA Have Data
To Satisfy This
J/ Requirement? (Yes,
Composition No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
§158.125 Residue Chemistry
(continued)
171-4 - Magnitude of the Residue -
Residue Studies (continued)
Foliage of Legume Vegetables
0 Bean Forage, Bean Vine
Hay
0 Pea Forage, Pea vine Hay
0 Soybean Forage and Hay
TEP
TEP
TEP
Yes
No
Yes
GS-0105-016
No
GS-0105-013
No
Fruiting Vegetables (except Curcurbits)
Peppers
Tomatoes
TEP
TEP
Partially
Yes
GS-0105-014* Yes5/
GS-0105-015 No
Small Fruits and Berries
Strawberries
TEP
Yes
GS-0105-017*
No
* Data submitted by Stauffer Chemical Co. These data may be compensable,
55
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Data Requirements Composition
Cereal Grains
0 Corn (fresh corn and grain) TEP
0 Sorghum (grain) TEP
Forage, Fodder, and Straw of Cereal
Grains
0 Corn (fodder and forage) TEP
0 Sorghum (fodder and forage) TEP
Miscellaneous Crops
0 Asparagus TEP
0 Mint TEP
0 Peanuts TEP
0 Sugarcane TEP
Residues in Tobacco TEP
Residues in Processed Commodities
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Partially
Partially
Partially
Yes
Partially
Yes
Partially
Partially
Partially
Bibliographic
Citation
GS-0105-013
GS-0 105-0 15
GS-0105-013
GS-0 105-0 15
GS-0105-017*
GS-0 105-0 17*
GS-0105-013
GS-0105-014*
00090850
Must Additional
Data Be Submitted
Under FIFRA Sectio
3(c)(2)(B)?2/
YesW
Yes^£/
Yes]V
No
Yes^f/
No
Yes^5/
Yes^V
Yes^V
0 Potatoes, Irish
TEP
No
Yes18/
* Data submitted by stauffer Chemical Co. These data may be compensable.
56
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
I/
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
§158.125 Residue Chemistry
(continued)
0 Sugar Beets (roots) TEP
0 Beans (green, dry, lima) TEP
0 Soybeans TEP
0 Tomatoes TEP
0 Corn (fresh corn and grain) TEP
0 Sorghum, grain TEP
0 Mint TEP
0 Peanuts TEP
0 Sugarcane TEP
Magnitude of the Residue in Food
producing Animals
Reserved^9/
No No20/
No No2"/
No No20/
Reserved21/
Reserved22/
No No2'-'/
Reserved22/
Reserved22/
0 Meat/Milk/Poultry/Eggs
TGAI or plant
metabolites
Reserved23/
57
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
§158.125 (Residue Chemisty
(continued)
J/ Composition: TGAI= Technical grade of the active ingredient; PAIRA= Pure active ingredient, radiolabelled; TEP=
Typical end-use product; EP= End-use product.
2/ Data must be submitted no later than March 31, 1987.
3/ A lactating ruminant (cow or goat) metabolism study and a poultry metabolism study are required. Should the
studies require a change in the existing nature of the tolerance to include other components, new analytical
methods may also be necessary.
4/ The original residue data adequately supported the present tolerance. However, a petition for a higher tolerance
is currently pending and awaits petitioner's response to data deficiencies.
5/ Data are required to reflect formulation types, maximum application rates, application methods, and geographical
representation.
6/ The data do not support the tolerance, although no residues of fonofos and fonofos oxon could be detected
from some aspects of this use. The over-the-top use is not represented by residue data.
~TJ The data do not support the tolerance because of inadequate sampling. Additional data will be required if
directions for use on turnips are established.
£/ There are no data for radishes, tops. Since there are directions for use on radishes, representative residue
data must be submitted, or the conditions for the crop grouping "leaves of root and tuber vegetables" must be
met.
9/ There are no residue data on peas, or peas-plus-pods. However, from the data on beans (green, dry, and lima),
no residues of fonofos would be expected.
VQ/ The tolerance cannot be reassessed since there are no directions for use appearing on the label.
11/ The residue data, after elimination of unreliable values, do not support the tolerance for this major crop.
Additional data on immature and mature corn reflecting the established use, including post-emergence (foliar)
aerial applications and the major corn-growing areas, are needed. Residue data on the processed commodities
of corn - oil (crude and refined), milled products, and cannery waste, are needed to determine if there is a
concentration of residues.
12/ The number of studies is not adequate to support the use pattern with a short PHI (14 days). Residue data
from representative growing areas reflecting this use must be submitted.
13/ Residue data on corn fodder and forage reflecting the registered uses, including the post-emergence (foliar)
aerial application and the major corn-growing areas, are needed.
14/ Information is needed on how promptly samplings were analyzed.
58
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
1158.125 Residue Chemistry
(continued)
15/ Additional data must be submitted reflecting established use patterns (including application by aircraft), at
maximum application rates, and from major peanut-growing areas. Data on the processed commodities of peanuts -
oil (crude and refined), meal, and soapstock are needed to determine if there is a concentration.
16/ Residue data, reflecting major geographical sites and a maximum number of possible postemergent applications to
determine realistic residue levels, are needed.
17/ Residue data on freshly-harvested tobacco from representative growing areas are required. If residues at 0.1 ppm
or more are detected, the pyrolysis products derived from the active ingredient must be characterized.
18/ A food/feed additive tolerance of 3 ppm will probably be necessary for processed potato waste. The data must
constitute random samplings of processed potato waste from operations in the pacific Northwest. Data is also
required for potato granules, chips, and dried products from potatoes treated with fonofos.
19/ A decision on the need for a food additive tolerance is being withheld at this time. Residue data is required
for processed commodities (dehydrated pulp, molasses, and refined sugar).
20/ Data not required because residues not found or expected in foods or processed commodities.
21/ A decision on the need for a food additive tolerance is being withheld at this time. If the required residue data
for oil and milled products indicate a residue concentration exceeding the tolerance for the raw agricultural
commodity, a food additive tolerance may be needed.
22/ A decision on the need for a food additive tolerance awaits submission of residue data on the raw agricultural
commodity.
23/ No conclusions can be drawn about the carry-over of residues and the need for tolerances for residues in meat,
milk, poultry and eggs until the requested metabolism (poultry and large lactating ruminant) studies, as well as
the new feeding studies, have been submitted and evaluated.
24/ All data citations are required to support the data requirement.
59
-------
TABLE A
GENERIC D'ATA REQUIREMENTS FOR FONOFOS
Data Requirement
J/ Use 2/
Composition Pattern
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Must Additional
Data Be Submitted
Bibliographic Under FIFRA Section
Citation 3(c) ( 2) (B)?3/
§158.130 Environmental Fate
DEGRADATION STUDIES-LAB;
161-1 - Hydrolysis
Photodegradation
161-2 - In water
161-3 - On soil
161-4 - In Air
METABOLISM STUDIES-LAB;
162-1 - Aerobic Soil
162-2 - Anaerobic Soil
162-3 - Anaerobic Aquatic
162-4 - Aerobic Aquatic
MOBILITY STUDIES:
TGAI or PAIRA A,B,H
TGAI or PAIRA A,B
TGAI or PAIRA A
TGAI or PAIRA A
TGAI or PAIRA A,B,H
TGAI or PAIRA H
TGAI or PAIRA
TGAI or PAIRA
163-1 - Leaching and TGAI or PAIRA
Adsorption/Desorption
163-2 - Volatility (Lab)
163-3 - Volatility (Field)
TEP
TEP
A,B,H
A
A
NO
No
NO
No
Yes
No
Not Applicable
Not Applicable
No
No
No
00073059**
00092024*
00052058*
Yes
Yes V
Yes V
Yes
NO
Yes 8/
Yes /
Yes 10/
Yes 11/
Data submitted by Stauffer Chemical Co. These data may be compensable. 60
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Data Requirement
V Use 2/
Composition Pattern
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
§158.130 Environmental Fate
(continued)
DISSIPATION STUDIES-FIELD;
164-1 - Soil
164-2 - Aquatic (Sediment)
164-3 - Forestry
164-4 - Combination and
Tank Mixes
164-5 - Soil, Long-term
ACCUMULATION STUDIES:
165-1 - Rotational Crops
(Confined)
165-2 - Rotational Crops
(Field)
165-3 - Irrigated Crops
165-4 - In Fish
165-5 - In Aquatic Non-Target
Organisms
TEP
TEP
TEP
A,B,H
TEP A,H
PAIRA A
TEP A
TEP
TGAI or PAIRA A,B
TEP
Partially
Not Applicable
Not Applicable
No
No
No
Not Applicable
Partially
Not Applicable
* Data submitted by Stauffer Chemical Co. These data may be compensable,
61
00090827*
00041235*
00090871*
GS-0105-018*
Yes 12/18/
Reserved 13/
No
Yes
Yes _]£/
Yes 17/
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
§158.130 Environmental Fate
(continued)
\J Composition: TGAI = Technical grade of the active ingredient; PAIRA = Pure active ingredient, radiolabelled;
TEP = Typical end-use product.
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
3/ Data must be submitted no later than March 31, 1987 .
4/ The study submitted was done on tap water, not sterile, as required.
5/ Radioactivity was not determined in the aqueous phase of the soil/water suspension.
6/ No study submitted, but is required.
7/ The studies combined togeather will fulfill this data requirement.
Q/ No study submitted, but is required.
9/ A TEP was used instead of the TGAI or PAIRA; bioassay not acceptable; inadequate control, column 7 inches; and
11.5" water used; an adsorption study is required for domestic use.
10/ Study submitted was not a TEP.
11/ No data submitted, but is required.
12/ Additional data required for representative granular formulation at a site in the corn belt.
13/ Data requirement for tank-mixes is reserved.
14/ Requirement depends upon results of aerobic soil metabolism studies; additional data are not required because more
than one-half of application dissipated before the recommended second application.
157 Study invalid because residues in the treated soil were extracted before the crops were planted.
16/ No data submitted, but all required.Depends upon finding significant residues from the confined study; decision to
be made following submission and evaluation of the confined study results.
177 An additional study is needed to provide residue data in visceral tissue and whole fish and to identify degradates.
18/ All data citations are required to support the data requirement.
62
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Does EPA Have Data
To Satisfy This
1/ Use 2/ Requirement? (Yes, Bibliographic
Data Requirement Composition Patterns No or Partially) Citation
§158.135 Toxicology
ACUTE TESTING:
81-1 - Oral LD50 - Rat TGAI A,B,H Yes 00090807
00059863*
00090806
00078777*
00090833*
00059860*
00078777*
81-2 - Dermal LD5Q - Rabbit TGAI A,B,H Yes 00059860*
00059863*
00090807
00090836*
00090806
00078777*
81-3 - Inhalation LC5Q Rat TGAI A,B,H Yes 00059859*
00059862*
81-7 - Acute Delayed TGAI A,B,H Partially 00090817
Neurotoxicity - Hen 00090819
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
NoV
NoV
NoV
YesV
* Data submitted by Stauffer Chemical Co. These data may be compensable.
63
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Does EPA Have Data
To Satisfy This
1/ Use 2/ Requirement? (Yes, Bibliographic
Data Requirement Composition Patterns No or Partially) Citation
§158.135 Toxicology
ACUTE TESTING:
81-1 - Oral LD5Q - Rat TGAI A,B,H Yes 00090807
00059863*
00090806
00078777*
00090833*
00059860*
00078777*
81-2 - Dermal LD5Q - Rabbit TGAI A,B,H Yes 00059860*
00059863*
00090807
00090836*
00090806
00078777*
81-3 - Inhalation LCgg Rat TGAI A,B,H Yes 00059859*
00059862*
81-7 - Acute Delayed TGAI A,B,H Partially 00090817
Neurotoxicity - Hen 00090819
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
NoV
NoV
NoV
Yes9/
* Data submitted by Stauffer Chemical Co. These data may be compensable.
64
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Data Requirement.
V Use 2/
Composition Patterns
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
B i bli o gr ap hi c
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
SUBCHRONIC TESTING:
82-1
82-2
82-3
82-4
- 90-Day Feeding -
Rodent, Non-rodent
- 21-Day Dermal - Rabbit
- 90-Day Dermal - Rabbit
- 90-Day Inhalation -
TGAI A,B,H partially 00090818
TGAI NA
TGAI NA
TGAI NA
Yes V
Rat
82-5 - 90-Day Neurotoxicity-
Hen/Mammal
TGAI
A,B,H
Provisional
CHRONIC TESTING;
83-1 - Chronic Toxicity - TGAI
2 species s Rodent
and Non-rodent
83-2 - Oncogenicity - TGAI
2 species: Rat and
Mouse preferred
83-3 - Teratogenicity - TGAI
2 species
83-4 - Reproduction - Rat TGAI
2-generation
A,B,H
A,B,H
A,B,H
A,B,H
Partially
Partially
Partially
Yes
00082233*
00082232*
00082232*
00118423*
00082234*
Yes (rodent)8/
Yes (2 rodents)
Yes (1 rodent)
No
* Data submitted by Stauffer Chemical Co. These data may be compensable.
65
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
_V 2/ Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition Pattern No or Partially) Citation 3(c) ( 2) (B)?3/
§158.140 Reentry Protection
132-1 - Foliar Dissipation TEP A,B,H No Yes^/
132-1 - Soil Dissipation TEP A,B,H No Yes4/
133-3 - Dermal Exposure TEP A,B,H No Yesf/
133-4 - Inhalation Exposure TEP A,B,H No Yes4/
_1/ Composition: TEP = Typical end-use product.
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
3/ Data must be submitted no later than March 31, 1987 .
4/ For each crop including home lawn and home garden, the registrant is required to propose an acceptable reentry interval
based on one of the following: (a) data on dissipation of foliar and/or soil residues of fonofos (decline curve), on
human exposure to those residues, and on toxicity of fonofos; or (b) determination of that time beyond which there are
no detectable, dislogeable residues remaining in the worker environment.
66
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
J/ Use 2/
Data Requirement Composition pattern
§158.145
Aquatic
Wildlife and
Organisms
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
Requirement? (Yes, Bibliographic Under FIFRA Section
No or Partially) Citation 3(c) ( 2) (B)?3/
AVIAN AND MAMMALIAN TESTING
71-1 -
71-2 -
71-3 -
71-4 -
71-5 -
AQUATIC
72-1 -
Avian Oral LD5Q TGAI A,B,H
Avian Dietary LC50 TGAI A,B,H
Wild Mammal Toxicity TGAI A,B,H
Avian Reproduction TGAI A,B,H
Simulated and Actual TEP A,B,H
Field Testing -
Mammals and Birds
ORGANISM TESTING
Freshwater Fish LC,-Q TGAI A,B,H
Yes 00090861* No /
00092027
Yes 00022923 No
Not Required
Not Required
Yes 00090849* No6/
00090882*
00090862*
GS-0 105-001*
GS-0 105-002*
Yes 00052064* No7/
00090820
GS-0 105-003
72-2 - Acute LC50 Freshwater TGAI
Invertebrates
72-3 - Acute LC50 Estuarine TGAI
and Marine organisms
72-4 - Fish Early Life TGAI
Stage and Aquatic
Invertebrate Life-Cycle
A,B,H
A,B,H
No
Not Required
No
Yes
* Data submitted by Stauffer Chemical Co. These data may be compensable.
67
Yes
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Data Requirement
J/ Use 2/
Composition Pattern
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Suhnitted
Under FIFRA Section
3(c)(2)(B)?3/
§158.145 Wildlife and
Aquatic Organisms
(continued)
72-5 - Fish - Life-Cycle
72-6 - Aquatic Organism
Accumulation
72-7 - Simulated or Actual
Field Testing -
Aquatic Organisms
TGAI A,B,H
TGAI, PAI OR A,B,H
Degradation
Product
TEP A,B,H
Reserved^/
Not Required
Reserved^/
_1/ Composition: TGAI = Technical grade of the active ingredient; PAI = pure active ingredient;
TEP = Typical end-use product;
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food Crop; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; l=lndoor.
3/ Data must be submitted no later than March 31, 1987.
4/ Reserved pending results of 72-4 and outstanding environmental fate data.
5/ Data citation 00090861 stands alone to fulfill the data requirement; 00092027 is considered useful information and
may be used in conjunction with other data to fulfill the requirement.
6/Data citations GS-0105-001 and GS-0105-002 stand alone to fulfill the data requirement; the other citations are con-
sidered useful information and may be used in conjunction with other data to fulfill requirements.
7/ Data citations GS-0105-003, 00052064 and 00090820 each stand alone to fulfill the data requirement for a warmwater
species; GS-0105-003 and 00090820 each stand alone to fulfill the coldwater species data requirement.
68
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Data Requirements
Does EPA Have Data
To Satisfy This
J/ Use 2/ Requirement? (Yes,
Composition Pattern No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?
§158.150 Plant Protection
121-1 - TARGET AREA EP
PHYTOTOXICITY
NONTARGET AREA PHYTOTOXICITY
TIER I
122-1 - Seed Germination/ TGAI
Seedling Emergence
122-1 - vegetative Vigor TGAI
122-2 - Aquatic Plant Growth TGAI
TIER II
123-1 - seed Germination/ TGAI
Seedling Emergence
123-1 - vegetative Vigor TGAI
123-2 - Aquatic Plant Growth TGAI
TIER III
124-1 - Terrestrial Field TEP
124-2 - Aquatic Field TEP
No
No
No
No
No
No
No
No
No
No 3/
No 3/
No 3/
No 3/
No 3_/
No 3/
No 3_/
No 3/
No 3/
1/ Composition: TGAI = Technical grade of the active ingredient; TEP = Typical end-use product.
EP = End-use product.
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food Crop; C=Aquatic, Food Crop;
~ D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
3/ These requirements are generally waived unless it is believed there is a phototoxicity problem.
69
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
_V Use 2/ Requirement? (Yes,
Pattern No or Partially)
Bi bliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
§158.155 Nontarget Insect
NONTARGET INSECT TESTING -
POLLINATORS ;
141-1 - Honey bee acute
contact
141-2 - Honey bee - toxicity
of residues on
foliage
141-3 - Wild bees important in
alfalfa pollination -
toxicity of residues
on foliage
141-4 - Honey bee subacute
feeding study
141-5 - Field testing for
pollinators
TGAI
TEP
TEP
A,B,H
A,B,H
A,B,H
(Reserved)
TEP
A,B,H
Yes
Yes
Not Applicable
Not Applicable
00043714**** No
05001991
00056152***** No
**** Data submitted by ICI Americas, inc. These data may be compensable.
***** Data submitted by Thompson-Hayward Chemical Co. These data may be eompensable.
70
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR FONOFOS
Data Requirement
J/ Use 2/
Composition Pattern
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)? 3/
§158.155 Nontarget Insect
(continued)
NONTARGET INSECT TESTING -
AQUATIC INSECTS;
142-1 - Acute toxicity to
aquatic insects
142-2 - Aquatic insect
life-cycle study
142-3 - Simulated or actual
field testing for
aquatic insects
TESTING - PREDATORS
143-1 - NONTARGET INSECT
thru AND PARASITES
143-3
(Reserved)
(Reserved)
(Reserved)
(Reserved)
1/ Composition: TGAI =* Technical grade of the active ingredient; TEP = Typical end-use product.
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop:
D=Aqautic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; l=Indoor.
3/ Data must be submitted no later than March 31, 1987.
71
-------
TABLE B
PRODUCT-SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING FONOFOS
V
Data Requirement Composition
§158.120 Product Chemistry
Product Identity
61-1 - Identity of Ingredients MP
61-2 - Statement of Composition MP
6 1-3 - Discussion of Formation MP
of Unintentional Ingredients
Analysis and Certification
of Product Ingredients:
62-1 - Preliminary Analysis MP
62-2 - Certification of Limits MP
62-3 - Analytical Methods for MP
Enforcement of Limits
Physical and Chemical
Characteristics
63-2 - Color MP
63-3 - Physical State MP
63-4 - Odor MP
63-7 - Density, bulk density, or MP
Does EPA Have Data
To Satisfy This
Requirement? ( Yes ,
No or Partially)
Yes
Partially
Partially
Partially
No
Yes
Yes
Yes
Yes
Yes
Must Additional
Data Be Submitted
Bibliographic under FIFRA Sectii
Citation 3(c) (2) (B)?2/8/
00059851* No
00059851* Yes3_/
00059851* Yesfy
00059851* YesV
Yes6/
GS-0 105-004 No
00059851* No
00059851* No
00059851* No
00059851* No
specific gravity
* Data submitted by Stauffer chemical Co. These data may be compensable.
72
-------
TABLE B
PRODUCT-SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING FONOFOS
Data Requirement
V
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
§158.120 Product Chemistry
(continued)
63-12 - pH
63-14 - Oxidizing or reducing
action
63-15 - FlammabLlity
63-16 - Explodability
63-17 - Storage Stability
63-18 - Viscosity
63-19 - Miscibility
63-20 - Corrosion characteristics
Other Requirements
64- 1 - Submittal of Samples
MP
MP
MP
MP
MP
MP
MP
MP
Not Required
Yes
No
Partially
No
No
No
Not Applicable
No
00059851*
No
Yes
00059851
Yes
Yes
Yes
Yes
* Data submitted by Stauffer Chemical Co. Data may be compensable.
73
-------
TABLE B
PRODUCT-SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING FONOFOS
§158.120 Product Chemistry
(continued)
\J Composition: MP = Manufacturing-use product; Choice = Choice of several test substances determined on a case-by-
case basis.
2/ Data must be submitted no later than September 30, 1984.
3/ A statement is needed to indicate the procedure of the manufacturing process that is now in actual use.
4_/ If the alternate procedure is in use, the registrant should discuss the possibility of introducing nitrosamine into
the technical chemical.
5/ A description of the method(s) and validating data used to obtain the preliminary analysis is needed. Five or more
representative samples should be analyzed.
6/ Certification of limits is required.
7/ The registrant should confirm that the submitted flash point is indeed the flashpoint for the technical chemical.
8/ Data reviewed refer only to Stauffer's technical grade material. There is no manufacturing-use product registered.
74
-------
TABLE B
PRODUCT-SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING FONOFOS
Does EPA Have Data
To Satisfy This
1/ Requirement? (Yes, Bibliographic
Data Requirement Composition No or Partially) Citation
§158.135 Toxicology
ACUTE TESTING
81-1 - Oral LD5Q - Rat MP Yes 00090807
00059863*
00090806
00078777*
00090833*
00059860*
81-2 - Dermal LD5Q - Rabbit MP Yes 00059860*
00059863*
00090807
00090836*
00090806
00078777*
81-3 - Inhalation LCgp - Rat MP Yes 00059859*
00059862*
81-4 - Primary Eye MP Yes 00078777*
Irritation - Rabbit
00059856*
81-5 - Primary Dermal MP Yes 00078777*
Must Additional
Data Be Submitted
Under FIFRA Sectio
3(c)(2)(B)?2/3/
NoV
NoV
NoV
No
Nof/
Irritation - Rabbit
81-6 - Dermal Sensitization
Guinea Pig
MP
No
Yes
* Data submitted by Stauffer chemical Co. These data may be compensable.
75
-------
TABLE B
PRODUCT-SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING FONOFOS
§158.135 Toxicology
(continued)
_!_/ Composition: MP = Manufacturing-use product.
2/ Data must be submitted no later than September 30, 1984.
2/ Data reviewed refer only to Stauffer's technical grade material. There is no manufacturing-use product registered.
4/ Each of these data citations stand alone to fulfill the data requirement.
-------
II. REQUIREMENT FOR SUBMISSION OF GENERIC DATA
A. This portion of the guidance document is a Notice
issued under the authority of FIFRA Section 3(c)(2)(B)
and describes, in table format, the data required
for maintaining the registrability of each product.
Additionally, a bibliography (Appendix II-l) is
included that identifies that data considered as
part of the data base supporting this standard. EPA
has determined that additional generic data described
in this Notice must be submitted to EPA for evaluation
in order to maintain in effect the registration(s)
of your product(s) identified as an attachment to
the cover letter accompanying this guidance document.
As required by FIFRA Section 3(c)(2)(B), you are
required to take appropriate steps to comply with
this Notice.
EPA may suspend the registration of each of those products
unless, within the specified time, you have informed EPA
how you will satisfy the requirements of this Notice.
Any such suspension will remain in effect until you have
complied with the terms of this Notice.
B. What Generic Data I/ Must Be Submitted. You may ascertain
which generic data you must submit by consulting Table A
at the end of this chapter. That table shows all the
generic data needed to evaluate the continued registrability •
of all products, and the dates by which the data must be
submitted. The required data must be submitted and any
necessary studies must be conducted in accordance with
EPA-approved protocols, the Pesticide Registration
Guidelines 2/, or data collected under the approved
protocols of the Organization for Economic Cooperation
and Development (OECD). If you wish not to develop data
which are necessary to support the registration or
reregistration of certain uses appearing in your labeling,
you may delete those uses at the time you submit your
revised labeling.
Also for certain kinds of testing (generally ecological
effects), EPA requires the test substance to be a "typical
formulation," and in those cases EPA needs data of that
_!/ Generic data pertain to the properties or effects of a
particular ingredient, and thus are relevant to an evaluation of
the risks of all products containing that ingredient (or all such
products having a certain use pattern), regardless of any such
product's unique composition or use. Product-specific data relate
only to the properties or effects of a product with a particular
composition (or a group of products with closely similar composition).
2_/ The Pesticide Registration Guidelines were reproposed on
November 24, 1982 in 47 Federal Register 53192.
77
-------
type for each major formulation category (e.g., emulsifiable
concentrates, wettable powders, granulars, etc.) These
are classified as generic data and when needed are
specified in Table A. EPA may possess data on certain
"typical formulations" but not others. Note; The "typical
formulation" data should not be confused with product-
specific data (Table B) which are required on each
formulation. Product-specific data are further explained
in Chapter IV of this document.
C. Options Available for Complying With"Requirements
to Submit Datei ~~
Within 90 days of your receipt of this Notice you must
submit to EPA a completed copy of the form entitled "FIFRA
Section 3(c)(2)(B) Summary Sheet" [EPA Form 8580-1, Appendix
II-2] for each of your products. On that form you must
state which of the following methods you will use to comply
with the requirements of this Notice:
1. (a) Notify EPA that you will submit the data, and
(b) either submit the existing data you believe
will satisfy the requirement, or state that
you will generate the data by conducting
testing. If the test procedures you will
use deviate from (or are not specified in)
the Registration Guidelines or protocols
contained in the Reports of Expert Groups
to the Chemicals Group, Organization for
Economic Cooperation and Development (OECD)
Chemicals Testing Programme, you must enclose
the protocols you will use.
2. Notify EPA that you have entered into an agreement
with one or more other registrants to jointly
develop (or share in the cost of developing) the
data. If you elect this option, you must notify EPA
which registrant(s) are parties to the agreement.
3. File with EPA a completed "Certification of Attempt to
Enter Into an Agreement With Other Registrants for
Development of Data" (EPA Form 8580-6, Appendix II-3)V
4. Request that EPA amend your registration by deleting the
uses for which the data are needed. (This option is not
available to applicants for new products.)
"*_/ FIFRA Section 3(c)(2)(B) authorizes joint development of
data by two or more registrants, and provides a mechanism by
which parties can obtain an arbitrator's decision if they agree
to jointly develop data but fail to agree on all the terms of
the agreement. The statute does not compel any registrant to
agree to develop data jointly.
(Footnote continued at bottom of next page)
78
-------
5. Request voluntary cancellation of the registration^)
of your products for which the data are needed. (This
option is not available to applicants for new products.)
D. Procedures for Requesting Changes in Testing Methodology
and Extensions of Time
EPA recognizes that you may disagree with our conclusions
regarding the appropriate ways to develop the required
data or how quickly the data must be submitted. If the
test procedures you plan to use deviate from (or are not
specified in) the registration guidelines or protocols
contained in the reports of the Expert Groups to the
Chemical Groups, Organization for Economic Cooperation
and Development (OECD) Chemicals Testing Programme, you
must submit the protocol for Agency review prior to the
initiation of the test.
If you think that you will need more time to generate the
required data than is allowed by EPA's schedule, you may
submit a request for an extension of time. The extension
request must be submitted in writing to the Product
Manager. The extension request should state the reasons
why you conclude that an extension is appropriate. While
EPA considers your request, you must strive to meet the
deadline for submitting the required data.
(Footnote continued from previous page)
In EPA's opinion, joint data development by all registrants
who are subject to the requirements to submit a pertinent item
of data or a cost-sharing agreement among all such registrants
is clearly in the public interest. Duplication of testing could
increase costs, tie up testing facilities, and subject an unneces-
sarily large number of animals to testing.
As noted earlier, EPA has discretion not to suspend the
registration of a product when a registrant fails to submit data
required under FIFRA Section 3(c)(2)(B). EPA has concluded that
it is appropriate to exercise its discretion not to suspend in
ways which will discourage duplicative testing. Accordingly, if
(1) a registrant has informed us of his intent to develop and
submit data required by this Notice? and (2) a second regis-
trant informs EPA that it has made a bona fide offer to the
first registrant to share in the expenses of the testing [on
terms to be agreed upon or determined by arbitration under FIFRA
Section 3(c)(2)(B)(iii)]; and (3) the first registrant has declined
to agree to enter into a cost-sharing agreement, EPA will not
suspend the second firm's registration. While the first firm is
not required to agree to jointly develop data, EPA is not required
to force the second firm to engage in economically inefficient
duplicative testing in order to maintain its registration.
79
-------
III. REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA
Note: This Section applies only to manufacturing-use
products, not end-use products.
A necessary first step in determining which statements must
appear on your product's label is the completion and submission
to EPA of product-specific data* listed on the form entitled
"Product Specific Data Report" (EPA Form 8580-4, Appendix III-l)
to fill "gaps" identified by EPA concerning your product. Under
the authority of FIFRA Section 3(c)(2)(B), EPA has determined
that you must submit these data to EPA in order to register or
reregister your product(s). All of these data must be submitted
not later than six months after you receive this guidance document,
"Product-Specific Data Requirements for Manufacturing-Use
Products" appearing in Table B permit you to determine which
product-specific data you must submit. This can be done by
examining the entries in the column of those tables entitled
"Must Data Be Submitted Under §3(c)(2)(B)."
*/ Product specific data pertains to data that support the
formulation which is marketed; it usually includes product chemistry
A^-t-r* ani^ arm-he -hoxi rr>1 oerv fla-ha.
data and acute toxicology data.
80
-------
IV. SUBMISSION OF REVISED LABELING AND PACKAGING INFORMATION
Note: This section applies to end-use products only to the
the extent described under Section II of this document.
Otherwise, the following information pertains exclusively to
manufacturing-use products.
The Agency requires applicants for registration or reregistra-
tion to ensure that each label (1) contains accurate, complete,
and sufficient instructions and precautions, reflecting the
results of data concerning the product and its ingredients, and
(2) incorporates labeling format and terminology which are suffi-
ciently standardized to avoid user confusion.
As part of your application, you will be required to submit
draft labeling consistent with: applicable product-specific
data; the precautionary statements and use directions; and the
regulations concerning classification [40 CFR §162.11(c)], pack-
aging [40 CFR §162.16], and labeling [40 CFR §162.10, Appendix
IV-1 an IV-2], as indicated by the following paragraphs of this
chapter of the guidance document.
If owners of currently registered products fail to submit
revised labeling and packaging information complying with this
Section and/or Section II, EPA may issue a notice of intent to
cancel the registration under FIFRA §6(b)(l).
A. Label Contents
40 CFR §162.10 (Appendix IV-1) requires that certain spe-
cific labeling statements must appear at certain locations
on the label. This is referred to as format labeling.
, Specific label items listed below are keyed to Tables D, E,
and F (Appendix IV-2).
Item 1. PRODUCT NAME - The name, brand, or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading. See Appendix
IV-1. [40 CFR §162.10(b)]
Item 2. COMPANY NAME AND ADDRESS - The name and address
of the registrant or distributor is required on the label.
The name and address should preferably be located at the
bottom of the front panel or at the end of the label text.
See Appendix IV-1. {40 CFR §162.10(c)]
Item 3. NET CONTENTS - A net content statement is required
on all labels. The preferred location is the bottom of the
front panel immediately above the company name and address,
or at the end of the label text. The net contents must be
stated in terms of weight, expressed as avoirdupois pounds
81
-------
and ounces, and stated in terms of the largest suitable unit,
i.e., "1 pound 10 ounces" rather than "26 ounces." In
addition to the required units specified, net contents may be
expressed in metric units. See Appendix IV-1. [40 CFR
§162.10(d)]
Item 4. EPA REGISTRATION NUMBER - The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase "EPA Registration No.," or "EPA
Reg. No." The registration number must be set in type of a
size and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
registration number and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency. See Appendix IV-1.
[40 CFR §162.10(e)]
Item 5. EPA ESTABLISHMENT NUMBER - The EPA establishment
number, preceded by the phrase "EPA Est." is the final estab-
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container -
It must also appear on the wrapper or outside container of
the package if the EPA establishment registration number on
the immediate container cannot be clearly read through such
wrapper or container. See Appendix IV-1. [40 CFR §162.10(f)]
Item 6. INGREDIENT STATEMENT - An ingredient statement
is required on the front panel and must contain the name and
percentage by weight of each active ingredient and the total
percentage by weight of all inert ingredients. The preferred
location is immediately below the product name. The ingredient
statement must run parallel with, and be clearly distinguished
from, other text on the panel. It must not be placed in the
body of other text. See Appendix IV-1. [40 CFR 162.10(g)]
Item 6A. POUNDS PER GALLON STATEMENT - For liquid
agricultural formulations, the pounds per gallon of active
ingredient must be indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS - All labels
are required to have precautionary statements grouped together
on the front panel, preferably within a block outline. The
table below shows the minimum type size requirements on
various size labels, as set forth in the Regulations.
82
-------
Size of Label Signal Word as Re- "Keep Out of Reach
on Front Panel quired Minimum Type of Children"
in Square Inches Size All Capitals _ as Required _
5 and under 6 point 6 point
above 5 to 10 10 point 6 point
above 10 to 15 12 point 8 point
above 15 to 30 14 point 10 point
over 30 18 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT - All labels are
required to have the statement "Keep Out of Reach of Children"
located on the front panel above the signal word except where
contact with children during distribution or use is unlikely.
See Appendix IV-1. [40 CFR §162 . 10 (h) (1 ) ( ii) ]
Item 7B. SIGNAL WORD - The signal word (Caution, Warning,
or Danger) is required on the front panel immediately below
the child hazard warning statement. See Appendix IV-1.
[40 CFR §162.10 (h)(l)(i)]
Item 7C. SKULL & CROSSBONES AND WORD "POISON" - On products
assigned a toxicity Category I on the basis of oral, inhala-
tion, or dermal toxicity, the word "Poison" shall appear on
the label in red on a background of distinctly contrasting
color and the skull and crossbones shall appear in immediate
proximity to the word poison. See Appendix IV-1. [40 CFR
Item 7D. STATEMENT OF PRACTICAL TREATMENT - A statement
of practical treatment (first aid or other) shall appear on
the label of pesticide products in toxicity Categories I,
II, and III. See Appendix IV-1. [40 CFR §162 . 10 (h) (1) ( iii) ]
Item 7E. REFERRAL STATEMENT - The- statement "See Side
(or Back) Panel for Additional Precautionary Statements" is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
See Appendix IV-1. [40 CFR §162 . 10 (h) (1 ) (iii) ] '
Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING - The
precautionary statements as listed below must appear together
on the label under the heading "PRECAUTIONARY STATEMENTS."
The preferred location is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline. Each
of the three hazard warning statements must be headed by the
appropriate hazard title. See Appendix IV-1. [40 CFR §162.10
(h) (2)]
83
-------
Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS - Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route (s) of exposure and the precautions taken to avoid
accident, injury or damage. See Appendix IV- 1 . [40 CFR §162.10
Item 8B. ENVIRONMENTAL HAZARD - Where a hazard exists to
non-target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage. See Appendix IV-1 . [40 CFR
Item 8C. PHYSICAL OR CHEMICAL HAZARD
1. Flammability statement. Precautionary statements
relating to flammability of a product are required
to appear on the label if it meets the criteria in
Appendix IV-3. The requirement is based on the results
of the flashpoint determinations and flame extension
tests required to be submitted for all products.
These statements are to be located in the side/back
panel precautionary statements section, preceded by
the heading "Physical/Chemical Hazards." Note that
no signal word is used in conjunction with the flam-
mability statements.
2. Criteria for declaration of non-f lammability . The
following criteria will be used to determine if a
product is non-flammable :
a. A "non-flammable gas" is a gas (or mixture of
gases) that will not ignite when a lighted match
is placed against the open cylinder valve.
b. A "non-flammable liquid" is one having a flash-
point greater than 350 °F (177°C) as determined
by the method specified in 40 CFR §163 . 61-8(c) (13 )
(ii) of Subpart D.
c. A "non-flammable aerosol" is one which meets the
following criteria:
i. The flame extension is zero inches, using the
method specified in 40 CFR §163 .61-8(c) (13 ) (ii ) ;
ii. There is no flash back; and
iii. The flashpoint of the non-volatile liquid
component is greater than 350°F (177°C),
determined by the method specified in 40 CFR
§163.61-8(c)(13)(i).
84
-------
3. Declaration of non-£lammability. Products which meet
the criteria for non-flammability specified above may
bear the notation "non-flammable" or "nonflammable
(gas, liquid, etc.)" on the label.
It may appear as a substatement to the ingredients
statement, or on a back or side panel, but shall not
be highlighted or emphasized (as with an inordinately
large type size) in any way that may detract from
precaution.
4. Other physical/chemical hazard statements. When
chemistry data submittedin accordance with 40 CFR
§163.61-10(c) demonstrate hazards of a physical or
chemical nature other than flammability, appropriate
statements of hazard will be prescribed. Such
statements may address hazards of explosivity,
oxidizing or reducing capability, or mixing with
other substances to produce toxic fumes.
Item 9. MISUSE STATEMENT - The following statement is
required on your label: "It is a violation of Federal law to
use this product in a manner inconsistent with its labeling."
See Appendix IV-1. [40 CFR §162.10(1)(2)(ii)]
Item 10A. STORAGE AND DISPOSAL BLOCK - All labels are
required to bear storage and disposal statements. These
statements are developed for specific containers, sizes, and
chemical content. Make certain that the statement you use
pertains specifically to your product. These instructions
must be grouped and appear under the heading "Storage and
Disposal" in the directions for use. This heading must.be
set in the same type sizes as required for the child hazard
warning. Refer to Appendix IV-5 for the latest specific
storage and disposal product label statements.
Item 10B. DIRECTIONS FOR USE - Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. When followed, directions must be adequate to
protect the public from fraud and from personal injury and to
prevent unreasonable adverse effects on the environment. See
Appendix IV-1. [40 CFR §162.10]
B. Collateral Information
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, and other graphic printed matter which is referred to
on the label or which is to accompany the product are termed
collateral labeling. Such labeling may not bear claims or
representations that differ in substance from those accepted
in connection with registration of the product. It should be
made part of the response to this notice and submitted for review.
85
-------
V- INSTRUCTIONS FOR SUBMISSION
All applications prepared in response to this Notice should
be addressed as follows:
Product Manager William H. Miller
Phone No. (703) 557-2600
Registration Division (TS-767)
Office of Pesticide Programs
Environmental Protection Agency
Washington, D.C. 20460
For each product for which continued registration is desired:
1. Within 90 days from receipt of this document, you must
submit the "FIFRA Section 3(c)(2)(B) Summary Sheet" EPA
Form 8580-1. Refer to Appendix II-2 with appropriate
attachments.
2. Within 6 months from receipt of this document registrants
must submit:
a. Confidential Statement of Formula, EPA Form 8570-4.
b. Product Specific Data Report, EPA Form 8580-4 (Appendix
III-l).
c. Two copies of any required product-specific data.
d. Two copies of draft labeling, including the label and
associated brochures. If current labeling conforms
to the requirements of this guidance document and the
results of the short-term data, the registrant may
submit such labeling. (End-use product labeling
needs to comply specifically with the instruction in
Section II of this guidance document.) The labeling
should be either typewritten text on 8-1/2 x 11 inch
paper or a mockup of the labeling suitable for
stortage in 8-1/2 x 11 inch files. The draft label
must indicate the intended colors of the final label,
clear indication of the front panel label, and the
intended type sizes of the text.
3. Within the time set forth in Table A, all generic data
must be submitted by the affected registrant(s).
Note: If for any reason any required test is delayed or aborted
so that meeting the agreed submission time will be delayed,
notify the Product Manager listed above.
After the Supreme Court has ruled on the Monsanto Decision,
you will be informed as to when you must submit your Application
for Amended Pesticide Registration (EPA Form 8570-1) and"the
associated data support information.
86
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
00022923 Hill, E.F.; Heath, R.G.; Spann, J.W.; et al. (1975) Lethal
Dietary Toxicities of Environmental Pollutants to Birds:
Special Scientific Report—Wildlife No. 191. (U.S. Dept.
of the Interior, Fish and Wildlife Service, Patuxent Wildlife
Research Center; unpublished report)
00028625 Simmon, V.F- (1979) In vitro Microbiological Mutagenicity
and Unscheduled DNA Synthesis Studies of Eighteen Pesticides:
Report No. EPA-600/1-79-041. (Unpublished study including
submitter summary, received Apr 3, 1980 under 279-2712;
prepared by SRI International, submitted by FMC Corp., Phila-
delphia, Pa.; CDLrTOX 099350-A)
00041235 Schulz, K.R.; Lichtenstein, E.P. (1971) Field studies on the
persistence and movement of Dyfonate in soil. Journal of-
Economic Entomology 64(1) :283-287. (Also'In'unpublished
submission received Jul 24, 1974 under 3F1379; submitted
by Stauffer Chemical Co., Richmond, Calif.; CDL:EAB 092139-F)
00043714 Atkins, E.L.; Kellum, D.; Neuman, K.J.; et al. (1975) Effect
of Pesticides on Apiculture: Project No. 1499. (Unpublished
study received Dec 2, 1976 under 10182-EX-3; prepared by
Univ. of California—Riverside, Citrus Research Center and
Agricultural Experiment Station, Dept. of Entomology,
submitted by ICI Americas, Inc., Wilmington, Del.; CDL:EEB
095996-D)
00052058 Hoffman, L.J.; McBain, J.B.; Menn, J.J. (1973) Environmental
Behavior of 0-Ethyl S-phenyl ethylphosphonodithioate
(Dyfonate): ARC-B-35. (Unpublished study received Apr 2,
1973 under 6F1379; submitted by Stauffer Chemical Co.,
Richmond, Calif.; CDL:EAB 093686-B)
00052064 Sleight, B.H., III (1972) Acute Toxicity of Dyfonate to
Bluegill (Lepomis macrochirus). (Unpublished study received
Apr 2, 1973 under 3F1379; prepared by Bionomics, Inc.,
submitted by Stauffer Chemical Co., Richmond, Calif.;
CDL:EEB 093686-H)
00052067 McBain, J.B.; Hoffman, L.J.; Menn, J.J. (1970) Metabolic
degradation of 0-Ethyl S-phenyl ethylphosphonodithioate
(Dyfonate) in potato plants. Journal of Agricultural and
Food Chemistry 18(65:1139-1144. (Also1In'unpublished
submission received Mar 26, 1974 under 3F1379; submitted
by Stauffer Chemical Co., Richmond, Calif.; CDLrRCB 094518-C)
87
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
00056152 Johansen, C.; Mayer, D.; Baird, C. (1973) Bee Research
Investigations, 1973. (Incomplete; unpublished study
received Apr 5, 1974 under 148-1170; prepared by Washington
State Univ., Dept. of Entomology and Alfalfa Seed Pest
Management Project, submitted by Thompson-Hayward Chemical
Co., Kansas City, Kans.; CDL:EEB 224671-S)
00059851 Duncan, W.P. (1977) Determination of Dyfonate(R) in Technical
Material and Formulations. Method no. WRC-77-6 dated Feb 17,
1977. (Unpublished study received Jan 20, 1978 under
476-1994; submitted by Stauffer Chemical Co., Richmond, Calif.;
CDL:RCB 232779-D)
00059856 Dean, W.P. (1977) Primary Skin Irritation Test in Rabbits:
Study No. 153-047. (Unpublished study received Jan 20,
1978 under 476-1994; prepared by International Research
and Development Corp., submitted by Stauffer Chemical Co.,
Richmond, Calif.; CDLiTOX 232779-J)
00059859 Dean, W.P. (1977) Acute Inhalation Toxicity (LC50) Study in
Rats: Study No. 153-047. (Unpublished study received Jan 20,
1978 under 476-1994; prepared by International Research and
Development Corp., submitted by Stauffer Chemical Co.,
Richmond, Calif.; CDL:TOX 232779-M)
00059860 Dean, W.P. (1977) Acute Oral Toxicity (LD50) in Male and
Female Albino Rats: Study No. 153-047. (Unpublished study
received Jan 20, 1978 under 476-1994; prepared by Inter-
national Research and Development Corp., submitted by Stauffer
Chemical Co., Richmond, Calif.; CDL:TOX 232779-N)
00059862 Elliott, C.B. (1972) Report to General Mills, Inc.: Acute
Vapor Inhalation Toxicity Study with Aliquat 336 in Albino
Rats: IBT No. N923. (Unpublished study received Jan 20,
1978 under 4761994; prepared by Industrial Bio-Test Labora-
tories, Inc., submitted by Stauffer Chemical Co., Richmond,
Calif.; CDL:TOX 232779-P)
00059863 Bullock, C. (1968) Acute Oral LD50 (Male and Female Rats);
Acute Dermal LD50 (Rabbits): Toxicological Summary T-1224.
(Unpublished study received Jan 20, 1978 under 476-1994;
submitted by Stauffer Chemical Co., Richmond, Calif.;
CDL:TOX 232779-Q)
88
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
00073059 Miles, J.R.W.; Tu, C.M.; Harris, C.R. (1979) Persistence of
Eight Organophosphorus Insecticides in Sterile and Non-
sterile Mineral and Organic Soils. Bulletin of Environmental
Contamination and Toxicology 22:312-318 (Also 'In' unpub-
lished submission received June 27, 1979 under 464-448,
submitted by Dow Chemical USA, Midland, Mich.; CDLsEAB
238974-A)
00078777 Holmes, P.A. (1978?) Dyfonate Technical: T-6461. (Unpub-
lished study received May 7, 1981 under 476-2028; submitted
by Stauffer Chemical Co., Richmond, Calif.; CDL:TOX 245491-A)
00082232 Banerjee, B.N.; Howard, D.; Woodard, M.W.; et al. (1968)
Dyfonate (N-2790) Safety Evaluation by Dietary Adminis-
tration to Rats for 105 Weeks. (Unpublished study received
Apr 5, 1970 under OF0960; prepared by Woodard Research
Corp., submitted by StaufChemical Co., Richmond, Calif
00082233 Woodard, M.W.; Donoso, J.; Gray, J.P.; et al. (1969) Dyfonate
(N2790) Safety Evaluation by Dietary Administration to Dogs
for 106 Weeks. (Unpublished study received Apr 5, 1970
under OF0960; prepared by Woodard Research Corp., submitted
by Stauffer Chemical Co., Richmond, Calif.; CDLsTOX 091638-C)
00082234 Woodard, M.W.; Leigh, C.L.; Woodard-, G. (1968) Dyfonate
(N-2790) Three-generation Reproduction Study in Rats.
(Unpublished study received Apr 5, 1970 under OF0960;
prepared by Woodard Research Corp., submitted by Stauffer
Chemical Co., Richmond, Calif.;
CDL:TOX 091638-D)
00090806 Horton, R.J. (1966) N-2790: Acute Oral LD50—Rats; Acute
Dermal Toxicity—Rabbits; Acute Eye Irritation—Rabbits:
Technical Report T-986. (Unpublished study received Dec
12, 1966 under 7F0548; submitted by Stauffer Chemical Co.,
Richmond, Calif.; CDL:TOX 090678-F)
00090807 Horton, R.J. (1966) N-2790: Acute Oral LD50—Rats; Acute
Dermal Toxicity—Rabbits; Acute Eye Irritation—Rabbits:
Technical Report T-985. (Unpublished study received Dec
12, 1966 under 7F0548; submitted by Stauffer Chemical Co.,
Richmond, Calif.; CDL:TOX 090678-G)
00090817 Wright, L.S., Beliles, R.P. (1966) N-2790: Safety Evaluation
by a Response in Rats to a Reactivation Agent. B. Neuro-
toxicity. (Unpublished study received Dec. 12, 1966 under
7F0548: prepared by Woodard Research Corp.; submitted by
Stauffer Chemical Co., Richmond, Calif.; CDL:TOX 090678-R).
89
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
00090818 Cockrell, K.O.; Woodard, M.W.; Woodard, G. (1966) N-2790:
Safety Evaluation of Repeated Oral Administration to Dogs
1966 under 7F0548; prepared by Woodard Research Corp., sub-
mitted by Stauffer Chemical Co., Richmond, Calif.; CDLcTOX
090678-V)
00090819 Woodard, M.W.; Woodard, G. (1966) N-2790 (Dyfonate):
Demyelination Study in Chickens. (Unpublished study received
Dec. 12, 1966 under 7F0548; Prepared by Woodard Research
Corp., submitted by Stauffer Chemical Co., Richmond, Calif.;
CDL:TOX 090678-U)
00090820 Beliles, R.P., Wright, L.S.; Knott,W. (1966) Safety
Evaluation on Fish and Wildlife (Bobwhite Quail, Rainbow
Trout and Bluegill Sunfish) (Unpublished study received
Dec 12, 1966 under 7F0548; prepared by Woodard Research
Corp,., submitted by Stauffer Chemical Co., Richmond, Calif.;
CDLiEEB 090678-V)
00090827 Kiigemagi, U.; Terriere, L.C. (1971) The persistence of
zinophos and dyfonate in soil. Bulletin of Environmental
Contamination & Toxicology 6(4) :355-361. (Also"In'unpublished
submission received Nov 1, 1971 under OF0960; submitted
by Stauffer Chemical Co., Richmond, Calif.; CDL:EAB 094505-F)
00090833 Duerden, B.; Bleiberg, M.J. (1968) Acute Oral LDSO's of Dy-
fonate 10 Granular vs. Dyfonate Technical: Thimet 10 Granular
vs. Thimet Technical for Rats. (Unpublished study received
Jan 21, 1970 under 476-1994\- prepared by Woodard Research
Corp., submitted by Stauffer Chemical Co., Richmond, Calif.;
CDL:TOX 100103-C)
00090836 Meyding, G.D. (1968) Acute Dermal Toxicity Studies with Four
Dyfonate(R) Granular Formulations: Report T-1154. (Unpub-
lished study received Jan 21, 1970 under 476-1994; submitted
by Stauffer Chemical Co., Richmond, Calif.; CDL:TOX 100103-F)
00090849 Midwest Research Farms (1974) Exposure of Pheasants to Grain
Sorghum Treated with Dyfonate. (Unpublished study received
Dec 9, 1974 under 476-2134; submitted by Stauffer Chemical
Co., Richmond, Calif.; CDL:EEB 132056-A)
00090850 Stauffer Chemical Company (1968) Study of Dyfonate Residue
in Various Crops|. Includes method dated Jan 10, 1967.
(Compilation; unpublished study, including FSDS nos. A
1691, A 2692, A 1484..., received Mar 19, 1968 under
476-1995; CDL:RCB 133070-B)
90.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
00090861 Piccirillo, V.J. (1977) Final Report: Acute Oral LD50 Study
in Mallard Ducks: Project No. 132-149. (Unpublished study
received Dec 13, 1977 under 476-1995; prepared by Hazleton
Laboratories America, Inc., submitted by Stauffer Chemical
Co., Richmond, Calif.; CDL:EEB 232469-A)
00090862 Piccirillo, V.J.; Truslow, J.U. (1977) Final Report: 14-day
Simulated Field Trial in Bobwhite Quail with Dyfonate 10
G and Dyfonate 20 G: Project No. 132-148. (Unpublished
study, including submitter summary, received Dec 13, 1977
under 476-1995; prepared by Hazleton Laboratories America,
Inc., submitted by Stauffer Chemical Co., Richmond, Calif.;
CDL:EEB 232469-C)
00090871 Talekar, N.S.; Sun, L.T.; Lee, E.M.; et al. (1977) Persistence
of some insecticides in subtropical soil. J. of Agricultural
and Food Chemistry 25(2)s348-352. (Also'In'unpublished sub-
mission received Dec 13, 1977 under 76-1995; submitted by
Stauffer Chemical Co., Richmond, Calif.; CDL:EAB 232469-M)
00090875 Hoffman, L.J.; Ford, I.M.; Menn, J.J. (1971) Dyfonate metab-
olism studies: 1. Absorption, distribution and excretion of
0-ethyl S-phenyl ethylphosphonodithioate in rats. Pesticide
Biochemistry and Physiology 1(3-4):349-355. (Also'In1unpub-
lished submission received Dec 13, 1977 under 476-1995;
submitted by Stauffer Chemical Co., Richmond, Calif.;
CDL:RCB 232472-F)
00090876 McBain, J.B.; Hoffman, L.J.; Menn, J.J.; et al. (1971)
Dyfonate metabolism studies: 11. Metabolic pathway of
0-ethyl S-phenyl ethylphosphonodithioate in rats. Pesticide
Biochemistry and Physiology 1(3-4):356-365. (Also'In'unpub-
lished submission received Dec 13, 1977 under 476-1995;
submitted by Stauffer Chemical Co., Richmond, Calif.;
CDL:TOX 232472-G)
00090878 McBain, J.B.; Menn, J.J. (19.69) S-methylation: Oxidation,
hydroxylation and conjugation of thiophenol in the rat.
Biochemical Pharmacology 18(9) :2282-2285 . (Also'In'unpub-
lished submission received Dec 13, 1977 under 476-1995;
submitted by Stauffer Chemical Co., Richmond, Calif.;
CDL:RCB 232472-J)
00090882 Fink, R.; Grimes, J. (1978) Final Report: 30-day Simulated
Field Study in Corn with Bobwhite Quail Utilizing Dyfonate
10-G and 20-G. (Unpublished study, including letter dated
Jan 17, 1979 from W.R. Hillebrecht to Marilyn Mautz and
submitter summary, received Jan 26, 1979 under 476-1995;
prepared by wildlife International Ltd., submitted by
Stauffer Chemical Co., Richmond, Calif.; CDL:EEB 238144-A)
91
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Suupporting
Registration Under the Standard
00092024 Hoffman, L.J.; Ross, J.H. (1971) Dyfonate Soil Metabolism:
Project 038022. (Unpublished study received Nov 1, 1971
under OE0960; submitted by Stauffer Chemical Co., Richmond,
Calif.; CDL:EAB 094505-D)
00092027 U.S. Fish and Wildlife Service (1968) Bird Toxicity or
Stupefacient Test Results. (Denver Wildlife Research
Center, Chemical Development Project, Section of Bird
Damage Control; unpublished study; CDL: EEB 21307-H)
00118423 Minor, J.; Downs, J.; Zwicker, G.; et al. (1982) A Teratology
Study in CD-1 Mice with Dyfonate Technical T-10192. Final
rept. (Unpublished study received Nov 9, 1982 under
476-1994; submitted by Stauffer Chemical Co., Richmond,
CA; CDL:248893-A)
05001991 Stevenson, J.H. (1978) The Acute Toxicity of Unformulated
Pesticides to Worker Honey Bees (Apis mellifera L.) Plant
Pathology 27( 1): 38-40 .
05018141 Chang, F.Y.; Smith, L.W.; Stephenson, G.R. (1971) Insecti-
cide inhibition of herbicide metabolism in leaf tissues.
Journal of Agricultural and Food Chemistry 19(6): 1183-1190.
GSO105-001 Booth,G.M.; Carter,M.W. (1980) A Simulated Field Study on
the Effect of Dyfonate 10G and 20G on Bobwhite Quail. (Un-
published study received Oct. 23, 1980; prepared by Brigham
Young University, Provo, Utah; submitted by Stauffer
Chemical Company: CDL:EEB 243582.(t-10126)
GS0105-002 Booth, G.M., Carter, M.W (1980) A Simulated Field Study on
the Effect of Band-incorporated Dyfonate 20G on Bobwhite
Quail. (Unpublished study received Oct. 23, 1980; prepared
by Brigham Young University, Provo, Utah; submitted by
Stauffer Chemical Company) CDL:EEB 243582 (t-10456)
GSO105-003 Johnson, W.W.,Finley, M.T. (1980) Handbook of Acute Toxicity
and Chemicals to Fish and Aquatic Invertebrates. U.S. Dept.
of the Interior, Fish and Wildlife Service, Resource Pub-
lication 137
GSO105-004 Zweig, G. (1973) Analytical Methods for Pesticides and Growth
Regulators. Volume VII. 269-277. Academic Press.
GSO105-005 Menzie, C. (1974) Metabolism of Pesticides: An Update. United
States Department of the Interior, Fish and wildlife Service,
Publication No. 184.
92
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GSO105-006 Lee, P.W., Allahyari, R., Fukuto, R.T. (1980) Absorption and
Metabolism of the Chiral Isomers of Fonofos in the Corn Plant.
J. of Environmental Science and Health B15(1):25-37-
GS0105-007 Fuhremann, T.W. (1980) A Comparative Study of the Persistence,
Movement and Metabolism of Six Carbon C14 Insecticides in Soil
and Plants. J. of Agricultural and Food Chemistry 28(2) :446-452.
GS0105-008 Talekar, N.S. (1973) Influence of Mineral Nutrients on the
Penetration, Translocation and Metabolism of C14 Dyfonate
in Pea Plants. J. of the Agricultural and Food Chemistry 21(5):
851.
GSO105-009 Hajjar, N.P. (1980) Flavin Adenine Dinucleotide-Dependent Mono-
oxygenose, Its Role in the Sulfoxidation of Pesticide
Sulfoxide in Mammals. Science 209:1134-1135.
GS0105-010 Lee, P.W., Allahyari, R., Fukuto, R. (1978) Studies on the Chiral
Isomers of Fonofos and Fonofos Oxon. III. In Vivo Metabolism.
Pesticide Biochemistry and Physiology 9:23-32.
GS0105-011 Lee, P.W. et. al. (1978) Studies on the Chiral Isomers of Fonofos
and Fonofos Oxon. II. In Vitro Metabolism. Pesticide Biochemistry
and Physiology 8:158-169.
GSO105-012 Wessel, J.R. Editor (1969) Methods for Individual Residues of Dyfonatf
Pesticide Analytical Manual II. Pesticide Section 120.221. p 1.
U.S. Dept. of Health and Human Services (Under "E" for 0-Ethyl-
S-phenyl ethylphosphonodithioate).
GS0105-013 Stauffer Chemical Co. (1966) Rotational Crops Residue Data.
(Unpublished study received Nov. 1, 1966 under 7F0548; CDL:RCB
114844).
GSO105-014 Stauffer Chemical Co. (1980) Summary of Pepper Residue Data in Support
of Application for Amended Registration (Unpublished study received
Oct. 15, 1980 under EPA Reg. No. 476-1995.)
GS0105-015 Stauffer Chemical Co. (1973) Seed Pod Vegetables. Dyfonate.
(Unpublished study received May 17, 1968 under 9F0760; CDL:RCB
118205)
GSO105-016 Stauffer Chemical Co. (1968) Root Crop Vegetable Residue Data.
Onions. (Unpublished study received Oct. 2, 1968 under 9F0760;
CDL:RCB 115733)
93
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GSO 105-017 Stauffer Chemical Co. ('1970 ) Leafy Vegetables: Dyfonate 10-G
Insecticide. (Unpublished study received March 31, 1970 under
OF0960; CDL:RCB 116583)
GS-0105-018 Stauffer Chemical Co. (1973) Exposure of fish to 14C labeled
Dyfonate Accumulation, Distribution and Elimination of
Residues. (Unpublished study received April 31, 1973 under
OF0960; prepared by Bionomics Inc.).
94
-------
Appendix III-l
PRODUCT SPECIFIC DATA REPORT
EPA Registration No. _Guidance Document for_
Date -
Registration
Guideline No.
§158.20
PRODUCT
CHEMISTRY
61-1
61-2
61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-10
63-11
63-12
63-13
63-14
63-15
63-16
63-17
63-18
63-19
Name of Test
Identity of
ingredients
Statement of
composition
Discussion of
formation of
ingredients
Preliminary
analysis
Certification of
limits
Analytical methods
for enforcement
limits
Color
Physical state
Odor
Melting point
Boiling point
Density, "bulk-
density, or
specific gravity
Solubility
Vapor1 pressure
Dissociation
constant
Oct and/water
partition
coefficient
PH
Stability
Oxidizing/reducing
reaction
Flammability
Explodability
Storage stability
Viscosity
Miscibility
Test not
required
for my
product
listed
above
(check
below)
9l
I am complying with
data requirements by
Citing MRID#
)
Submit-
ting
Data
(At-
tached)
(For EPA Use Only)
Accession Numbers
Assigned
_
-------
63-20
63-21
§158.135
TOXICOLOGY
81-1
81-2
81-3
bl-4
81-5
81-6
Corrosion
characteristics
Dielectric break-
down voltage
Acute oral LD-50,
rat
Acute dermal
LD-50
Acute inhalation,
LC-50 rat
Primary eye
irritation, rabbit
Primary dermal
irritation
Dermal sensitiza-
tion
-------
APPENDIX IV-2
LABELING REQUIREMENTS OF THE FIFRA, AS AMENDED (REFER TO THE SAMPLE LABELS FOLLOWING)
ITEM
1
2
3
4
5
6A
6B
7
7A
7B
LABEL ELEMENT
Product name
Company name
and address
Net contents
EPA Est. No.
EPA Reg. No.
Ingredients
statement
Pounds /gal Ion
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where dosage
given as Ibs.
ai/unit area
All products
All products
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
None
None
None
None
Front panel
Front panel
Front panel
Front panel
Front panel
PREFERRED
Center front
panel
Bottom front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel,
immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the main
ingredients
statement
Above signal
word
Immediately
below child
hazard
warning
COMMENTS
If registrant is not the producer, must
be qualified by "Packed for . . . , "
"Distributed by. -. .," etc.
May be in metric units in addition to
U.S. units
Must be in similar type size and run
parallel to other type.
May appear on the container instead of
the label.
Text must run parallel with other text
on the panel.
All front panel precautionary statements
must be grouped together, preferably
blocked.
Note type size requirements.
Note type size requirements.
97
-------
APPENDIX IV-2 (continued)
ITEM
LABEL ELEMENT
APPLICABILITY
OF REQUIREMENT
PLACEMENT ON LABEL
REQUIRED | PREFERRED
COMMENTS
7C
7D
7E
8
8A
8B
Skull & cross-
bones and word
POISON (in red)
Statement of
practical
treatment
Referral
statement
Side/back panel
precautionary-
statements
Hazards to
humans and
domestic
animals
Environmental
hazards
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxicity
All products
in Categories
I, II, and III
All products
where pre-
cautionary
labeling
appears on
other than
front panel.
All products
All products
in Categories
I, II, and III
All products
Front panel
Category I:
Front panel
unless refer-
ral statement
is used.
Others:
Grouped with
side panel
precautionary
statements .
Front panel
None
None
None
Both in close
proximity to
signal word
Front panel
for all.
Top or side
of back panel
preceding
directions
for use
Same as above
Same as above
Must be grouped under the headings in
8A, 8B, and 8C; preferably blocked.
Must be preceded by appropriate signal
word.
Environmental hazards include bee
caution where applicable.
98
-------
Bi
p»UC*ui>O'«*n>
HA/»nos to
It DOMISIC
CAUtlON
on
HAZARDS
USE
t itoMon «r r«i**ri IM to
>» * mnrvr
StM[M(Nt
STORAGE AND
DISPOSAL
COOP
PRODUCT
NAME
101AI
100 (Kt \
rnoouc> CONIAIUS IDS of
KEEP OUT OF REACH OF CHILDHEN
CAUTION
STATEMENt OF rn»CIC*t 1ol»!M£Ht
r ON SK»| •
v WE YES - ' :
SEE SOE PANri fon AootiioNAi rntcAuionAnt
Mro n
TOWN
tSfABllSHMEN? NO
Era niciSIHMiON NO —
NH
99
60
^^
r~—
7A
CHOP
CHOP
CHOP*
WAnnANff StAltMENl
-------
PRECAUTIONARY STATEMENTS
HAZARDS TO HUMANS
(I DOMESTIC ANIMALS)
DANGER
ENVIRONMENTAL HAZARDS
PHYSICAL OR CHEMICAL
HAZARDS
DIRECTIONS FOR UK
(it tfoMon <* F«4*fl W* to
tHt prodkjct ^
RE-ENTRY STATEMENT
STORAGE AND
DISPOSAL
STORAGE i"
DISPOSAL:
CHOP:
RESTRICTED USE
PESTICIDE
For retail ill* to and us* only by Certified Applicator*
or perjonj under their direct tupervltlon and only for
those ujei covered by the Certified Applicator* Certifi-
cation.
PRODUCT
NAME
ACTIVE WOREDIENT:
WERT NOREDCNTS:
TOTAL.
10000%
THIS PRODUCT CONTAWS IBS OF PER GALLON
KEEP OUT OF REACH OF CHILDREN
DANGER -POISON
STATEMENT OF PRACTICAL TREATMENT
F SWALLOWED:
r WHALED =
FON 8KN==
r M EYES =
MFO BY .
«r»tr
MO
EPA REGISTRATION NO.
NET CONTENTS:
SEE SIDE PANEL FOR ADDITIONAL PRECAUTIONARY STATEMENTS
CHOP;
CROP:
CROP:
CROP:
CROP:
WARRANTY STATEMENT
1 00
-------
. 20004468 /Bafr
EPA REGISTRATION NO.
F1FRA SECTION 3(C)(2){B) SUMMARY SHEET '
PRODUCT NAME
APPLICANTS NAME
DATE GUIDANCE OCOJMejfl
Whh raspact to tha raquiremant to submit "ganarfc* data fmpoaad by t)M FIFRA sactioft 3(C}(2HB) notka contafnad in itit rafwanead
Suidanca Occaraant, I im responding in tha following mannan
O t. I wfll sibinit ditt br a tfantiy aamn to atfafy *« fonowing rtquinmmtt. If tht tut procadum I will ust daviats from (or n no
cpaeifftd in) ttit RiQtstntion Guidelints or tha Protocol* contiinid in tha Raports of Expart Groups to tha Chamkait Group, OEfi^
ClwnkalxTarttaa Prognmma, 1 andoca tha pratoeais that I will uaat
D Z. (hava mtarad Into an agnamant with ona or mora othar rtgtitnnts undar F1FRA action 3(C3(2HBKfiJ to atirfy KM following dtt
raauirtmtntt. Tha tntx, and any raquirtd protoeols, will ba afamittad to EPA by;
NAME OF OTHER REGISTRANT
D 3^ I andoa a eomplattd "Ciniftcttion of Atlimpt to Enttr Into an Agnamant with Othar Ragistrants for Oavaiopmant of Data-" with
wpect to tha following data raquiramantc
D*. I raqusn that you amind my ragatmion by dalating tha following uas (this option is not availabla to applicants for naw produe&jt
O 5. I nquast voluntary eancallation of tha registration of this product (This option it not avaflabia to applicant! for mw producti)
REGISTRANTS AUTHORIZED REPRESENTATIVE
SIGNATURE
101
DATE
EPA fora B80.1
-------
OMB Approval Ne. 200G-Q4€8 fSxeires: 12-31~83r
CERTIFICATION OF ATTEMPT TO ENTER
INTO AN AGREEMENT WITH OTHER REGISTRANTS
,f.lifv.artffvALL fouritml FOR DEVELOPMENT OF DATA
| j w> ure mm* !-.•<.»>. ••• ^.~3...^-- >—, JOove
"*»« igreed to submit the data listed In paragraph (2) above In iceordaneg with the Notice. ? understand SPA will promptly inform
me whether my firm must submit data to avoid suspension of its registrstionls) under FIFRA Section 3(e)(2}{8). (This lUtamant
d°«* not apply to applicants for new products.) I give EPA permission to disdoss this statsmsrst upen request.
"BONAMS
BATE
-------
PHJJUCT SPECIFIC DATA. KEPUKC
EPA aegistraticn No.
Docxnsnt for
Date
Registration
Guideline No.
S158.20
CSIMISra
61-1
61-2
61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-ltt
63-11
i Itest not I.
I [required j r am" complying with 1
£ [fer uy Idata requirements by 1
| [product I ISuiwit-l
E {listed 1 (ting I
ft labove I (Data I (For EPA Ose Only)
I Kchedc t l(Afc~ lAccession Hunters
1 ' Kama of Test Ibelcw) | Citing MRID* I tached)! Assigned
i * i 1 i
t r i f i
i r r r r
t Identity of i I 11
r Ingredients f \ 1 f
1 Statement of i 1 11
f composition 1 t \ \
i Discussion of I I I I
I formation of j 1 1 I
r ingredients It If
1 Preliminary. 1
I analysis t
1 Certification of I
t limits f
I Analytical methods!
Efmm nj. f- ir.-i_-i__T_- n h 1
toe encorcement i
t limits I
1 Color
1 Physical state
1 Odor
1 Melting point
1 Boiling point !
J Density, bulk- I
1 density, or I
t specific gravity I
1 Solubility
i Vapor pressure
i Dissociation (
f constant f
1 Octanol/water i
I; partition f
f coefficient \
63-12 1 pH I
63-13
63-14
63-15
63-16
63-17
63-18
63-19
I Stability |
1 Oxidizing/reducing 1
1 reaction |
1 Flantnability
I Explodability
1 Storage stability
1 Viscosity
\ I
r i
i i
r r
i i
i i
r i
i i
r
__
i \
\ \
\
\ \
.
1 Miscibiliry . 4r\7
-------
o*-.<;u | uDrrcsicn i
f characteristics
63-21
$158.135
TCKICDLOGY
81-1
81-2
I
81-3 |
1
81-4
81-5
1
81-6 |
I
1 Dielectric break-
down voltage
r
Acute oral 12-50, 1
rat T
Acute dermal I
r ID-BO F
Acute inhalation r t
LC-50 rat I
Primary eye I
irritation, rabbit!
Primary dermal. I
irritation 1
Dermal sensitiza-
f tion I
i i
1
f r
i
! f
I I
r r
i i
r r i
i i
i r
i i
! f
t i
r t
i i
r \ \
i
1
.
-
104
-------
APPENDIX IV-2
LABELINQ JffiQUIREMENlS OP Uffi PIFW, AS AMENDED (REFER TO THE SAMPLE LABELS
1
ITEM
1
2
3
4
$
SA
6B
7
7A
>
LABEL ELEMENT
Product name
1 Company name
and address I
1
Net contents
1
APPLICABILITY
OP REQUIREMENT
All products
All products
All producta
PLACEMENT ON LABEL
REQUIRED
Front panel
Hone
None
I EPA Est. No. | All products ! None
1 ! '— j
! EPA Reg. No.
Ingredients
statement
Pounds/gal kwt
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
All products i None
\
\
1
1
All products
Liquid products
I where dosage
given as Ibs,
ai/unit area
All products
All products
All products
1
1
Front panel
PREFERRED
Center front
panel
Bottom front
panel or end
of label text
Bottom front
! panel or end
of label text
Front panel
Front panel ,
imnediatfily
before or
following
Reg. No.
Immediately
following
product name
Front panel Directly below
the main
! ingredienta
statement
Front panel
1
I
Front panel
Front panel
1
-
Above signal
word
1
Immediately
below child
, hazard
L ..warning
1
COMMENTS
If registrant is not the producer? must
be qualified by "Packed for • , ,»*
"Distributed by. . .," etc.
May be in metric units in addition to
U.S* units
Must be In similar type size and run
parallel to other type.
May appear on the container instead of
the label.
|
.
Text must run parallel with other text
on the panel.
All front panel precautionary statement^1
must be grouped togetherff preferably
blocked.
Note type size requirements*
Note type size requirements?
i u :i • '
-------
rran .
7C
7D
7E
$
"flA
LABEL ELEMENT
Skull 6 cross-
bones and word
POISON (in red)
Statement of
practical
treatment
Referral
statement
Side/back panel
precautionary
statements
Hazards to
humans and
domestic
animals
• — — -
APPLICABILITY 1
OF REQUIREMENT
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxicity
All products
in Categories
I, II, and III
All products
where pre-
cautionary
labeling
appears on
other than
front panel.
All products
All products
in Categories
I, II, and III
•
« P*°a
PLACEMENT
REQUIRED |
Front panel
Category It
Front panel
unless refer-
ral statement
is used.
Others t
Grouped With
side panel
precautionary
statements.
Front panel
None
Hone
1 *xx* ,U6
WLABEI -—
PREFERRED
Both in close
proximity to
signal word
Front panel
for all.
Ibp or side
of back panel
preceding
directions
for use
Same as above
Saersa as above
i
Must be grouped under the headings In
8Ar 8Br and BCf preferably blocked*
Must; be preceded by appropriate signal
word.
Environmental hazards include' bee
«=aufcAc»» Mheire aneVI 4 nntvl *>
-------
APPENDIX 1V-2 (continued
ITEM
BC
9A
9C
IDA
ioc
lOD
U.S.
1
LABEL ELEMENT
Physical or
chemical
hazards
Restricted I
block I
1
Misuse
statement:
Re-entry
statement
Storage and
disposal block
Directions v
for use x
APPLICABILITY |
OF REQUIREMENT |
All pressurized I
products t others 1
with flash
points under 1
150»F I
All restricted
products
1
All products
All
chol inesterase
inhibitors
All products
All products
PLACEMEN!
REQUIRED
None
Top center
of front
panel
Immediately
following
statement of
classifica-
tion or
ahead of
directions
for use
In the
directions
If or use
In the
directions
for use
I
I
None
1
f ON LABEL
PREFERRED
Same as above
1
I Preferably
blocked
!
Immediately
after misuse
statement
Immediately
before
specific
directions
for use or
at the end of
directions
!f or use
None
COMMENTS
*
Includes a statement of the terms of
restriction* The wordg "RESTRICTED USB
PESTICIDE11 must be same type size as
signal word*
Must be set apart and clearly distin-
guishable from from other directions
for use«
.
May be in metrid as well as U.S. units
107
-------
Appendix IV-3
PHYSICAL-CHEMICAL HAZARDS
Criteria Required Label Statement
r*. Pressurized Containers
V Flashpoint; at or below
2Q«Fr or if there- is a
flashback at any valve
opening*
B«. Flashpoint above 20*F
and not over 80®Fj. or
if the flame extension
is. more than 13 inches
long at a distance of
£ inches from the
valve opening.
CV ALL OTHER PRESSURIZED
CONTAINERS
II. Non-Pressurized Containers
A. Flashpoint at or below
20 "F*
B* Flashpoint above 20•?
and over
Extremely flammable*
Contents under pressure.
Keep away front fire, sparks
and heated surfaces. Do no
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparksr And flame. D
not puncture or incinerate
container. Exposure to
temperatures above 130'F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130*F
nay cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces*
Flammable* Keep away from
beat and ©p@n flame.
Cv Flashpoint over 80*F
and not over ISO*F.
D. Flashpoint above
150*F.
or store near
h«afe and ©pon flame.
Nose
1 O 8
-------
Appendix XV-5
STORAGE AND DISPOSAL INSTRUCTIONS FOR PESTICIDES
All products are required to bear specific label instructions
about storage and disposal* Storage and disposal instructions
must, be grouped together in the directions for use portion of
the label under the heading; STORAGE AND DISPOSAL. Products
intended solely for domestic use need not. include the heading-
•STORAGE AND DISPOSAL.* The STORAGE AND DISPOSAL heading
must appear in the minimum type size listed below:
1
(Size of label
(front panel in
(square inches
1
(Above 10 to 15 » » » _
(Above 15 to 30 » * » «
(Over 30. ,».,-»*»
I
I
t
t
(
Required type size
for the heading
STORAGE AND DISPOSAL
(all capitals)
1
r
i
i
i
i
i
r
I
1
Storage and disposal instructions must be set apart and
clearly distinguishable from other directions for use.
Blocking storage and disposal statements with a solid line is
suggested as a means of increasing their prominence*
A.- Storage Instructions;
All product labels are required to have appropriate storage
instructions. Specific storage instructions are not prescribed,
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors:
1» Conditions of storage that might alter the composition or
usefulness of the pesticide. Examples could be temperature
extremes, excessive moisture or humidity, heat, sunlight,
friction, or contaminating substances or media.
2. Physical requirements of storage which might adversely
affect the container of the product and its ability to
continue to function properly. Requirements might include
positioning of the container in storage, storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
3. Specifications for handling the pesticide container,
including movement of container within the storage area,
proper opening and closing procedures (particularly- for
opened containers), and measures to minimize exposure
while opening or closing container.
-------
Appendix 17^-5
(continued)
4~ Instructions on what to do if the container is damaged in
any way, or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs,
5* General precautions concerning- locked storage,, storage in
original container only, and separation of pesticides
during storage to prevent cross-contamination of other
pesticides, fertilizer, food, and feed*
£» General storage instructions for household products should
emphasize storage in original container and placement in
locked storage areas*
B» Pesticide Disposal Instructions?
The label of all products, except those intended solely for
domestic user must bear explicit instructions about pesticide?
disposal,. The statements listed below contain the exact wording-
that must appear on the label of these productsr
I* The labels of all products, except domestic use, must
contain the statement, "Do not contaminate water, food.-
or feed by storage or disposal»•
2» Except those products intended solely for domestic user
the labels of all products that contain active ingredients
appearing on the "Acutely Hazardous" Commercial Pesticide
Products List (RCRA "E" List) at the end of this appendix
or are assigned to Toxicity Category I on the basis of
oral or dermal toxicity, skin or eye irritation potential,
or Toxicity Category I or II on the basis of acute inhala-
tion toxicity must bear the following pesticide disposal
statementt
"Pesticide wastes are acutely hazardous* improper dis-
posal of excess pesticide, spray mixture, ©r rinsate Is
a violation of Federal Law* If these wastes earns®t; b©
disposed of by use according to label instructions,
contact your State- Pesticide or Environmental Csatrsl
Agency,- or the Hazardous Waste representative at the
nearest EPA Regional Office for guidance*.88
The labels of all products, except those intended
domestic use, containing active ©r inert ingredients
that appear on the "Toxic* Commercial Pestieide Products
List {RCRA *F" List) at the end ©f this appendix or
presently meet" any of the criteria in Si"
261 for a hazardous waste must bear the
disposal statement:
-------
Appendix IV-5
(continued)
"Pesticide wastes are toxic. Improper disposal of excess
pesticide, spray mixture, or rinsate is a violation of
Federal Law. If these wastes cannot be disposed of by
use according to label instructions, contact your State
Pesticide or Environmental Control Agency, or the Hazardous
Waste representative at the nearest EPA Regional Office
for guidance.*
Labels for all other products, except those intended for
domestic user must bear the following pesticide disposal
statements
•Wastes resulting from the use of this product may be
disposed of on site or at an approved waste disposal
facility."
3» Products intended for domestic use only must bear the
following disposal statement: "Securely wrap original
container in several layers of newspaper and discard in
trash."
C. Container Disposal Instructions
The label of each product must bear container disposal
instructions appropriate to the type of container.
1» All products intended for domestic use must bear one
of the following container disposal statements £
Container Type
Statement
{Non-aerosol products
{(bottles, cans, jars)
I Non-aerosol products
I (bags)
1 Aerosol products
1
Do not reuse container (bottle, can, jar).
Rinse thoroughly before discarding in trash.
Do not reuse bag. Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or nuncture.
The labels for all other products must bear container disposal
instructions, based on container type, listed below:
Container Type
Statement
1Metal
{containers
I(non-aerosol)
I
I
iPlastic containers
1
I
Triple rinse (or equivalent). Then offer I
for recycling or reconditioning, or puncture 1
and dispose of in a sanitary landfill, or by!
other procedures approved by state and local 1
authorities. '' I
I
Triple rinse (or equivalent). Then offer 1
for recycling or reconditioning, or puncture!
and dispose of in a sanitary landfill, or 1
incineration, or, if allowed by state and I
local authorities, by burning. If burned, !
stay out of smoke.
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved state and local procedures.
!Gl&ss containers
1 1
-------
Appendix XV-
Ccontinued)
Container Type
[Fiber arums
Iwith liners
\
I
I
1
{Paper and
[plastic bags
I
1
r
t
(Compressed gas
[cylinders
Statement
| Completely empty liner by shaJcing and
1 tapping sides and bottom to loosen clinging
j particles* Empty residue into application
f equipment* Then dispose of liner in a
f sanitary landfill or by incineration if
t allowed by state and local authorities^
1 If drum is contaminated and cannot- be
f reused^- , dispose of in the same manner.
I Completely empty bag into application
r equipment*. Then dispose of empty bag irr
t a sanitary landfill or by incineration r
t or, if allowed by State and local
[ authorities, by burning. If burned, stay
1 out of smoke.
1 Return empty cylinder for reuse (or
1 similar wording).
I
1
I
I
1
t
r
i
r
r
i
i
r
i
r
^Manufacturer may replace this phrase with one indicating whether
and how fiber drum may be reused*
2* The labels for all other products must bear container
disposal instructions, based on container type, listed
on the first page of this Appendix.
1 12
-------
Appendix IV-5
(continued)
Pesticides that are hazardous wastes under 40 CFR 261.33(e) and
when discarded.
"Acutely Hazardous* Commercial Pesticides (RCSA *E* List},
Active Ingredients, (no inertsU
Acrclein
Aldicarb
Aldrin
Allyl alcohol
Aluminum phosphide
4-Aminopyridine
Arsenic acid
Arsenic pentoxide
Arsenic trioside
Calcium cyanide
Carbon disulfide
p-Chloroaniline
Cyanides (soluble cyanide salts, not specified elsewere)
Cyanogen chloride
2-Cyclohexyl-4,6-dinitrophenol
Dieldrin
0,0-Diethyl S-[2-ethylthio)ethyl] phosphorodithioate
(disulfotonr Di-Syston)
0,0-Diethyl 0-pyrazinyl phosphorothioate (Zinophos)
Dimethoate
OrO-Dimethyl 0-p-nitrophenyl phosphorothioate (methyl parathion
4#6-Dinitro-o-cresol and salts
4,6-Dinitro-o-cyclohexylphenol
2,4 Dinitrophenol
Dinoseb
Endosulfan
Endothall
Endrin
Pamphur
Fluoroacetamide
Heptachlor
Hexanethyl tetraphosphate
Hydrocyanic acid
Hydrogen cyanide
Methomyl
alpha-Naphthylthiourea (ANTD)
Nicotine and salts
Octamethylpyrophosphoraaide (OHPA, schradan)
Parathion
1 13
-------
Appendix IV-5
(continued)
'Acutely Hazardous* Commercial Pesticides (RCSA *E* List)
Active Ingredients continued;
phenylmercuric acetate (FMA)
Phorate ^
potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
Strychnine and salts
0,0,0,0-Tetraethyl dithiopyrophosphate (sulfotepp)
Tetraethyl pyrophosphate
Thallium sulfate
Thiofanox
Tozaphene
Warfarin
Zinc phosphide
There are currently no inert ingredients for commercial pesticides
oa the "Acutely Hazardous" List (RCRA "B" List) »
1 14
-------
Appendix IV-5
(continued)
•Toxic* Commercial Pesticide Products (RCPA *F^ List)
Active Ingredients;
Acetone
Acrylonitrile
Amitrole
Benzene
Bis(2-ethylhexyl)pthalate
Cacodylic acid
Carbon tetrachloride
Chloral (hydrate)
Chlordane (technical)
Chlorobenzene
4-Chloro-m-cresoL
Chloroform
o-Chlorophenol
4-Chloro-o-toluidine hydrochloride
Creosote
Cresylic acid
Cyclohexane
Decachlorooctahydro-l,3,4-metheno-2H-cyclobuta[c,dl-pentalen-2-one
(kepone, chlordecone)
l,2-Dibromo-3-chloropropane (DBCP)
Dibutyl phthalate
S-3,3-(Dichloroallyl diisopropylthiocarbamate (diallate, Avadex)
o-Dichlorobenzene
p-Dichlorobenzene
Dichlorodifluoromethane (Freon 12*)
3,5-Dichloro-N-(l,l-dimethyl-2-propynyl) benzamide (pronanide,Kerb)
Dichloro diphenyl dichloroethane (DDD)
Dichloro diphenyl trichloroethane (DDT)
Dichlorethyl ether
2,4-Dichlorophenoxyacetic, esters and salts (2,4-D)
1i2-Dichloropropane
1,3-Dichloropropane (Telone).
Dimethyl phthalate
Ethyl acetate
Ethyl 4,4f-dichlorobenzilate (chlorobenzilate)
Ethylene dibromide (EDB)
Ethylene dichloride
Ethylene oxide
Formaldehyde
Furfural
Eexachlorobenzene
Hexachlorocyclopentadiene
Hexachloroethane
Hydrofluoric acid
115
-------
Appendix IV-5
(continued)
*Toxic* Commercial Pesticide Products (RCSA *F* List)
Active Ingredients;
Isobutyl alcohol
Lead acetate
Lindane
Maleic hydrazide
Mercury
Methyl alcohol
Methyl bromide
Methyl chloride
2>2'-Methylenebis (3,4,6-trichlorophenol) (hexachlorophene)
Methylene chloride
Methyl ethyl Jcetone
4-Methyl-2-pentanone (methyl isobutyl Jcetone)
Naphthalene
Nitrobenzene
p-Nitrophenol
Fentachloroethane
Pentachloronitrobenzene (FC27B)
Pentaclorophenol
Phenol
Phosphorodithioic acid, 0,0-diethyl, methyl ester
Propylene dichloride
Pyridine
Resorcinol
Safrole
Selenium disulfide
Silvex
1,2,4,5-Tetrachlorobenzene
1,1,2,2-Tetrachloroethane
Tetrachloroethylene
2', 3,4 , 6-Te trachlorophenol
Thiram
Toluene
Irlfl-Trichloroethane
Trichloroethylene
Trichloromonofluoromethane (Preon 11*)
2f4r5-Trichlorophenol
2,4,6-Trichlorophenol
2,4,5-Trichlorophenoxyacetic acid (2,4,5-T)
Xylene.
16
-------
Appendix X7-5
Ccontinued)
•Toxic* Commercial Pesticide Products (RORA
Inert Ingredients;
'P* List)
Acetone
Ac'etonitrile
Acetophenone
Acrylic acid
Aniline
Benzene
Chlorobenzene
Chloroform
Cyclohexane
Cyclohexanone
Dichlorodifluoromethane (Preon 12*)
Diethyl phthalate
Dime thylamine
Dimethyl phthalate
1,4-Dioxane
Ethylene oxide
Formaldehyde
Formic acid
Isobutyl alcohol
Meleic anhydride
Methyl alcohol.(methanol)
Methyl ethyl ketone
Methyl methacrylate
Naphthalene
Saccharin and salts-
Thiourea
Toluene
lrl,l-Trichloroethane
Irlr2-Trichloroethane
Trichlorofluoromethane (Free
Vinyl chloride
Xylene
1 17
------- |