GUIDANCE FOR THE
REREGISTRATION OF PESTICIDE PRODUCTS

             CONTAINING

            TRICHLORFON

      AS THE ACTIVE INGREDIENT

              (057901)

            CAS 52-68-6
  ENVIRONMENTAL PROTECTION AGENCY
    OFFICE OF PESTICIDE PROGRAMS

      WASHINGTON, D.C.  20460

           JUNE 30, 1984

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                        TABLE OF CONTENTS


      Introduction 	        1-3

I.    Regulatory Position	        4-78

II.   Requirement for Submission of Generic Data	       79-Hi6

III.  Requirement for Submission of Product-Specific
      Data	      117-120

IV.   Submission of Revised Labeling and Packaging
      Information	      1 "21-12 6
      A.  Label Contents
          1.  Product Name 	
          2.  Company Name and Address  	
          3.  Net Contents 	
          4.  Product Registration Number	
          5.  Producing Establishment
              Registration Number	
          6A  Ingredient Statement 	
          6B  Pounds Per Gallon Statement	
          7.  Front Panel Precautionary Statements  .
          7A  Child Hazard Warning Statements.  .  .  .
          7B  Signal Word	
          7C  Skull and Crossbones and  Word Poison  .
          7D  Statement of Practical Treatment  .  .  .
          7E  Referral Statement 	
          8.  Side/Back Panel Precautionary Labeling
          8A  Hazard to Humans and Domestic Animals.
          8B  Environmental Hazard 	
          8C  Physical or Chemical Hazard	
          9   Misuse Statement 	
          IDA Storage and Disposal Block 	
          10B Directions for Use 	
      B.  Collateral Information .

V.    Instructions for Submission.

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                            APPENDICES


          Bibliography  	   II-l

          FIFRA S3(c)(2)(B) Summary Sheet -
            EPA Form 8580-1 	   II-2

          Certification of Attempt to Enter  Into  an
          Agreement With Other Registrants for  Development
          of Data EPA Form 8580-6	   II-3
                                                       i

          Product Specific Data Report  (End-Use Products).... II.I.rJL.

          Sample Label Formats  	   IV-1

          Table of Labeling Requirements 	  IV-2

          Physical/Chemical Hazards Labeling Statement 	  IV-3

          Storage and Disposal Instructions	  IV-5

Note:     Appendices IV-4 and IV-6 are  not germane to  this    	
          document and are not included.
                                11

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                         INTRODUCTION

     The Federal Insecticide, Fungicide, and Rodenticide Act
(FIFRA Section 3(g), as amended in 1978, directs EPA to
reregister all pesticides as expeditiously as possible.  Each
registrant of a manufacturing use product of the active
ingredient who wishes to continue to sell or distribute that
product must apply for reregistration.

     To fulfill this Congressional mandate, we have established
the Registration Standards program which will review all pesti-
cide active ingredients first registered before January 1,
1977. These pesticides will be reviewed in use clusters
which are prioritized on the basis of a ranking scheme giving
preference to pesticides used on food and feed crops.

     The Registration Standards program involves a thorough
review of the scientific data base underlying pesticide
registrations and an identification of essential but missing
studies which may not have been required when the product
was initially registered or studies that are now considered
insufficient.  Our reassessment results in the development
of a regulatory position, contained in this document, on
each pesticide and its uses. The regulatory position may
require the registrant to modify product labels to provide
additional precautionary statements, restrict the use of the
pesticide to certified applicators, provide reentry intervals,
modify uses or formulation types, specify certain packaging
limitations, or other requirements to assure that proper use
of the pesticide poses no potential adverse effects to human
health or the environment.

     The scientific review, which is not contained herein
but is available upon request, concentrates on the technical
grade of the active ingredient and identifies missing generic
data.  However, during the review of these data we are also
looking for potential hazards that may be associated with
the formulated (end-use) products that contain the active
ingredient. If we find serious concerns, we will bring
formulated products under the provisions of the Registration
Standards program to the extent necessary to protect the
public.

     EPA has the authority under FIFRA $3(c)(2)(B) to require
that certain registrants submit generic data that will answer
our questions regarding the hazard that may result from the
intended use of the pesticide under review.  Further, S3(c)
(2)(B) provides that these data are to be submitted by
those registrants who do not qualify for the formulator's
exemption [FIFRA S3(c)(/)(D)].  Normally, this means that
the registrants who are responsible for filling the data
gaps are the manufacturing-use product producers (basic

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suppliers of the active ingredient).  However, end-use producers
will not qualify for the formulator's exemption if the source
of their active ingredient: (1) is not registered with EPA,
and/or (2) is produced by the registrant's firm, or a firm
which has ownership in common with the registrant's firm.
These end-use producers can qualify for the formulator's
exemption if they change their source of supply to a registered
source, provided the source does not share ownership in
common with the registrant's firm.  If the end-use product
registrant decides to switch sources, a new Confidential
Statement of Formula, EPA Form 8570-4, must be submitted to
the appropriate Product Manager within 90 days of receipt of
this Guidance Document.  The chart on the following page
shows what is generally required of those who do and do not
qualify for the formulator's exemption in the Registration
Standards program.

     If you decide to request the Agency to discontinue the
registration of any of your products subject to the reregistra-
tion requirements of this Guidance Document, please notify
the Product Manager named in the cover letter, within 90
days from the receipt of this document, that you wish to
voluntarily cancel the registration(s).  If you decide to
maintain your product registration(s), you must provide the
information described in the following pages within the time-
frames outlined. EPA will issue a notice of intent to cancel
or suspend the registration of any currently registered
product if you fail to comply with the requirements set
forth in this Guidance Document.

    This Guidance Document will be supplemented by EPA with
additional information about compliance with data support
requirements.  In Monsanto v. Administrator, EPA was recently
enjoined from implementing in any way the "mandatory data
licensing" aspects of S3(c)(l)(D) of FIFRA. EPA is assessing
the implications of the injunction for the reregistration
process. Because this situation is currently unresolved, EPA
has decided to proceed with the requirements in this Guidance
Document which do not relate to compliance with the $3(c)(l)(D)
provisions and to supplement the Document with additional
guidance when circumstances permit.  Failure to comply with
the provisions of the subsequent guidance will also result
in issuance by EPA of an intent to cancel the affected product
registration(s).

    Registrants are reminded that $6(a)(2) of FIFRA requires
you at any time to submit factual information raising concerns
of possible unreasonable adverse effects of a pesticide. You
should notify the Agency of interim results of studies in
progress if those results show possible unreasonable adverse
effects.

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  PRODUCTS SUBJECT TO THE
  REGISTRATION STANDARDS PROGRAM
  ACTION(S) REQUIRED TO
  MAINTAIN REGISTRATION
I. Products That Do Not Qualify
   For The Formulator's Exemption

   A. Single Active Ingredient
      Products*
These products must be reregis-
tered. To obtain reregistration,
labeling, packaging and data
requirements must be satisfied
in accordance with the Regis-
tration Standards Guidance
Document.
   B. Multiple Active Ingredient
      Products
These products will not be
reregistered at this time.
However, generic data required
to continue the registration of
the active ingredient under
review, as described in the
Registration Standards Guidance
Document, will be required and
some labeling precautions may
also be required.
II.  Products That Do Qualify For
     The Formulator's Exemption
Only when additional restric-
tions or labeling are needed to
protect man or the environment
will these products be subject
to the Registration Standard
requirements. Affected products
will be dealt with in a variety
of ways, including but not
limited to the Label Improvement
Program and special intent
to cancel notices.
*End-use products of registrants who also produce a manufacturing-
use product will not be required to be reregistered provided that
registrant fulfills the requirements specified in the Guidance
Document for manufacturing-use product(s). Such end-use products
will be subject to the labeling changes required for products in "II"
above. If there are no manufacturing-use products registered by any
company end-use products will be required to be reregistered.

NOTE: If all registrants in "I" above fail to meet the requirements in
I-A and B above, then the registrants in  'II" lose their right to
qualify for the formulator's exemption and 'Become subject to the
requirements in I-A and B.	

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II.  REGULATORY POSITION AND RATIONALE






A.  INTRODUCTION






This Guidance Document describes the Agency's regulatory posi-



tion on registered manufacturing-use products (MPs) containing



the insecticide trichlorfon.  This position is based on a con-



sideration of all accepted uses of pesticide products containing



trichlorfon as the sole active ingredient, under Sections 3 and



24(c) of the FIFRA.  Other considerations include the known



chemical, environmental, and the toxicological characteristics



of this pesticide and the established tolerances for residues



in or on food and feed commodities.  From these considerations



the Agency sets forth the data and labeling requirements that



must be met by registrants and applicants of trichlorfon pro-



ducts in order for a product to be registered or reregistered



under this Document.  Only those registration and labeling



requirements for current and future substantially similar MPs



are addressed here.  Future MPs that differ appreciably from



those described in this Document may require that amendments



be made to this Document to reflect the differences.






B.  Chemical Description and Use Profile






Trichlorfon is a common name for the insecticide dimethyl-



(2,2,2-trichloro-l-hydroxyethyl)phosphonate as determined by

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the International Organization For Standardization (ISO).  The



Chemical Abstracts Registry (CAS) number is 52-68-6,  and the



EPA Chemical Reference number is 057901.  Trichlorfon registered




in the U.S. is manufactured by Mobay Chemical Corp.,  Intrachem



S.A., Aceto Chemical Co., Inc., and Makhteshim Beer-Sheva



Chemical Works Ltd.






Technical trichlorfon is a white crystalline solid with a melt-



ing point of 81-82°C.  The empirical formula is C/jHgO^^P and



the molecular weight is 257.6.  The boiling point for technical



trichlorfon is 100°C at 0.1 mm Hg and the vapor pressure is



7.8 mm Hg at 20°C.  Trichlorfon is soluble in water (9* at



20°C), alcohols, methylene chloride and ketones and slightly



soluble in aromatic solvents.






There are thirteen federally registered manufacturing-use pro-



ducts (MPs) containing trichlorfon as a single active ingre-



dient and one MP containing trichlorfon in combination with



other active ingredients.  A total of 118 end-use products



containing trichlorfon are registered under Section 3 of FIFPA



and seventeen are registered under Section 24(c) of FIFRA (Spe-



cial Local Needs Registration).






Trichlorfon is a selective insecticide registered for use on a



variety of vegetable, fruit, and field crops; livestock;

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ornamental and forestry plantings; in agricultural premises



and domestic dwellings; and for the control of parasites on



fish in designated aquatic environments.  Trichlorfon is an



organophosphate pesticide exhibiting both contact and stomach



poison action.  Trichlorfon is commercially available as



emulsifiable concentrate, soluble concentrate (liquid, solid),



pressurized liquid, ready to use liquid, pelleted/tableted,



impregnated material, dust, granular, and wettable powder/dust,



Most products are applied by using either ground or aerial



equipment.  The particular type of equipment is determined



by site and equipment available.  Trichlorfon is classified



as a general use pesticide.






C.  Regulatory Position






Based on a review and evaluation of data and other relevant



information on trichlorfon, the Agency has made the following



determinations:






1.  The data that have been reviewed do not show that the



    criteria listed in 40 CFR S162.11(a) have been met or




    exceeded for the uses of trichlorfon listed in this



    Guidance Document.  However, because of gaps in the data



    base, the Agency cannot complete a full assessment of




    trichlorfon.

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2.  The Agency is unable to complete a tolerance reassess-



    ment because of extensive residue chemistry and toxicology



    data gaps.  Future requests for tolerances will not he con-



    sidered or approved until all the chronic toxicology data



    requirements have been satisfied.






3.  No federal or state reentry intervals have been established



    for trichlorfon.  However, based on available environmental



    fate and toxicology data, the Agency is requiring an interim



    reentry interval of 24 hours.  This reentry interval will be



    re-evaluated when the data requirements in Tables A and B



    have been satisfied.






4.  Manufacturing-use pesticide products containing trichlorfon



    as the sole active pesticide ingredient may be registered



    for sale, distribution, reformulation, and use, subject to



    the terms and conditions specified in this Guidance Document,






5.  Registrants must provide or agree to develop additional



    data, as specified in the data tables, in order to maintain



    existing registrations or to obtain new registrations for



    substantially similar MPs.






6.  There are unique label precautions that must be included on



    the labeling for trichlorfon products.  These precautions




    are cited in Section G of this Document.

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 D.  REGULATORY RATIONALE
JThe Agency has determined that it should continue to allow



 the registration of trichlorfon7after considering the following:






     1.   Dichlorvos RPAR
 Dichlorvos (DDVP),  a putative metabolite of trichlorfon,  was



 originally referred and accepted for the Rebuttable Presumption




 Against Registration (RPAR)  process because scientific studies



 indicated that dichlorvos was mutagenic as well as potentially •



 carcinogenenic,  neurotoxic and teratogenic in laboratory  animals



 The RPAR Decision Document on Dichlorvos was issued by the



 Agency on September 30, 1982.  In this document (i.e., Decision



 Document on Dichlorvos, Office of Pesticides and Toxic



 Substances, U.S.  EPA,  Washington, D.C., September 30, 19R2)



 the Agency evaluated the available data on dichlorvos in



 accordance with  40  CFR  162.11 (Criteria for Determination of



 Unreasonable Adverse Effects) and concluded that the existing



 evidence did not support the issuance of an RPAR for dichlorvos



 and consequently, that  an RPAR for trichlorfon as a precursor



 of dichlorvos was also  not warranted.






 The DDVP Decision Document concluded that additional data on



 carcinogenicity  and mutagenicity were needed to complete  the



 risk assessment  for dichlorvos.  DDVP was removed from the

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RPAR process and returned to the registration process.  On



March 23, 1983, the Agency issued a Data Call-in Notice



under FIFRA Section 3(c)(2)(b), reguesting data on potential



mutagenic effects of dichlorvos be submitted by March 23,



1985.  However, the Agency will wait until the continuing



National Cancer Institute (NCI) dichlorvos bioassay on



carcinogenicity is completed (currently scheduled for com-



pletion in 1985) and evaluated prior to determining if



additional data on the carcinogenicity of dichlorvos will



be reguired.  Since dichlorvos can be metabolized from



trichlorfon, evaluation of these studies will be necessary



for the completion of the trichlorfon risk assessment.






    2.  Trichlorfon RPAR






Trichlorfon was originally referred and entered the



Rebuttable Presumption Against Registration (RPAR) process*



because scientific studies suggested that trichlorfon may be



oncogenic, teratogenic, fetotoxic and mutagenic.  In this



document the Agency has evaluated the available data on



trichlorfon in accordance with 40 CFR 162.11 (Criteria for



Determination of Unreasonable Adverse Effects) and concluded



that the existing evidence does not support the issuance of



an RPAR for trichlorfon, because the existing data base is



inadeguate for a valid risk assessment.  Additional data are



required to complete the risk assessment for trichlorfon.








*Federal Register, Vol. 43, No. 77, Thurs. April 20, 1978.

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Oncogenicity, chronic feeding, teratogenicity, mutagenicity,



inhalation, dermal, neurotoxicity, and metabolism studies



are required as specified in Table A.  A decision as to



whether trichlorfon should reenter the RPAR process will he



made when these studies are completed.





    3.  Acute Toxicity





Adequate data indicate that trichlorfon is in Toxicity Category



II on the basis of acute oral effects and Category III on



the basis of dermal effects.  Human hazard precautionary



statements associated with these Toxicity Categories [40 CFR



162.10 (h)(2)(i)]  should minimize the acute hazards associated



with these routes of exposure.  Adequate studies are unavailable



to fully assess the acute inhalation, primary eye, primary dermal



sensitization effects of trichlorfon to humans.  The Agency



has no valid acute inhalation, primary eye, dermal, or dermal



sensitization data for trichlorfon manufacturing-use products.





    4.  Subchronic and Oncogenicity and Chronic Feeding





The Agency has no acceptable subchronic studies, chronic



feeding or Oncogenicity studies.  The available data suggest



that trichlorfon induces tumors at high dietary levels



(500 and 1000 ppm), but are insufficient as the basis for



an oncogenic risk assessment because of major protocol
                               10

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design and/or reporting deficiencies, as follows:






    (i)  High mortality in all groups (control and experi-



         mental), resulting in shortened duration of studies;






   (ii)  inadequate dosage regimens;






  (iii)  too few tissues (selected only at terminal sacrifice)



         in 5 or less animals per sex group examined;






   (iv)  inadequate histopathological data.








Additional subchronic, oncogenicity and chronic feeding studies



are required as specified in Table A.






5.  Mutagenicity






There is sufficient evidence that trichlorfon or its degrada-



tion products is mutagenic to bacteria and mammalian cells



in vitro, and thus these data requirements are satisfied.



Trichlorfon may also be clastogenic (cause chromosome break-



age), as suggested by inadequately-controlled and/or incon-



clusive studies in vivo.  Inconsistent results have been



reported with many systems, however, and the instability of



trichlorfon may be an important consideration in interpreting



these data.  Therefore, additional data on chromosome aberrations



are required.
                                  11

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    6.  Teratogenicity






Trichlorfon administered by gavage to pregnant animals during the



critical period of major organogenesis appears to be fetotoxic



and teratogenic in rabbits, rats, mice and hamsters, but only at



doses greater than those causing significant maternal effects



and/or death.  However, a teratology study in the rat where



trichlorfon was fed during gestation did report an increased



rate of anomalies at a dietary dose below the dose producing



maternal effects.  This study was not considered acceptable



according to current Agency guidelines since the authors did



not present the teratology data on a litter basis nor indicate



the number of fetuses with specific malformations.  Further,



an insufficient number of pregnant females were available for



analysis.  Therefore the Agency is requiring an adequate



dietary teratology study in the rat to resolve this issue.






    7.  Tolerance Assessment and Exposure






The ADI has been based on a NOEL for cholinesterase inhibition



from a one-year feeding study in dogs.  However, this study



has now been judged inadequate according to current Agency



guidelines since there were only 2 animals per sex per feeding



level; individual animal data were not fully reported; and



gross histopathologic examinations were incomplete or inade-



quate, and only a limited number of tissues were sampled.



Further, hyperplastic adrenal nodules were found at all dose



levels tested including the dose from which the ADI was
                                 12

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based.  Because of the above listed deficiencies in the



design and conduct of the study, the Agency lacks confidence



in interpreting the results.  The significance of the nodules



will be determined by a required additional dog study.  The



present study does not support the ADI regardless of the



reported results.  A complete tolerance reassessment is



necessary with a new data base, including chronic feeding



studies, being required.






Based on residue chemistry and toxicology considerations,



however, there is no adequate data to confirm that current



tolerances are likely to expose the public to unreasonable



adverse effects.






    8.  Incidents



The Pesticide Incident Monitoring System (PIMS) reports covering



the period from 1966 to January 1980 include 52 incidents



involving the pesticide trichlorfon.  Of these, 22 involved



trichlorfon alone, while the remaining 30 involved trichlorfon



and other pesticides.  The human and domestic animal adverse



effects reported in these incidents appear to have been the



result of improper handling, lack of protective clothing or



ingestion of trichlorfon.
                                 13

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    9.   Ecological Effects






    Based on studies available to assess hazards to wildlife



and aquatic organisms, technical trichlorfon is characterized



as highly to moderately toxic to both cold water and warm water



fish, very highly toxic to freshwater invertebrates and highly




toxic to birds.  Label precautions required by this Guidance



Document should reduce the hazard to wildlife and aquatic



organisms.






   10.   Environmental Fate






Available data are insufficient to fully assess the environ-



mental  fate of trichlorofon.  Trichlorfon degrades rapidly



in aerobic soils under nonsterile conditions, but in sterile



soils trichlorfon is stable.  Trichlorfon also degrades



rapidly in alkaline pond water but remains stable in pond water



under acidic conditions.  The major degradate in both soil



and pond water is DDVP.  Trichlorfon is very mobile in soils



of varying textures and organic contents.  The potential for




ground  water contamination by the parent compound may be



mediated by its degradation in soil, however, the potential



for ground water contamination by DDVP cannot be assessed



due to data gaps.  Forestry and aquatic field dissipation




studies did not show a potential for trichlorfon to persist



in leaves, leaf-litter, soil, water, or sediment, nor did



they show a potential for trichlorfon to accumulate in



nontarget fish.
                                 14

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    11.   Summary of Regulatory Rationale






Under FIFRA the Agency cannot cancel or withhold registra-



tion simply because data are missing or inadeguate (see



Sections 3(c)(2)(B) and 3(c)(7) of the FIFRA). Rather,



issuance of this Guidance Document provides a mechanism for



identifying data needs.  These data will be reviewed and



evaluated when they are received and the Agency will determine



at that time whether they will affect the registrations of



trichlorfon.






E.  CRITERIA FOR PRODUCTS SUBJECT TO THE GUIDANCE DOCUMENT






This Guidance Document covers products that contain trichlorfon



as the sole active ingredient and the chart in the Introduction



describes the extent to which such products are subject to



this Guidance Document.  Applicants for registration or



reregistration of such products must comply with all the terms



and conditions described herein.  This includes making a



commitment to fill data gaps on a schedule specified by the



Agency.   Also,, applicants for reregistration must follow the



instructions contained in this Guidance Document and complete



and submit the appropriate forms within the specified times.



End-use products must be in compliance with the label changes



specified in this Document.
                                15

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F.  ACCEPTABLE RANGES AND LIMITS


    1.   Product Composition Statements


To be covered under this Guidance Document, manufacturing-use

products must contain trichlorfon as the sole active ingredient.

Each MP formulation proposed for registration or reregistration

must be fully described with an appropriate certification of

limits.


    2.   Acute Toxicity Limits


The Agency will consider for registration any MP whose acute

toxicity category (I, II, III, IV) is supported by adequate

acute toxicology data and appropriate precautionary statements

in the labeling.


G.  REQUIRED LABELING


All manufacturing-use products containing trichlorfon must

bear appropriate labeling as specified in 40 CFR 162.10.


    1.   Label Requirements for Manufacturing-Use Products


        a.  Ingredient Statement


The ingredient statement for MPs must list the active ingredient

as:

     (dimethyl-(2,2,2-trichloro-l-hydroxyethyl)
                phosphonate		% .
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        b.  Use Pattern Statement


All MPs must state that they are intended only for formulation

into end-use products (EPs) for any of the use patterns listed

below.  A limiting factor will be the data that support each

use pattern.  No use may be included on the label where the

registrant fails to agree to comply with the data requirements

in either Table A or Table B for that use pattern.


        0  Terrestrial, non-domestic, food crop uses on:

           Alfalfa (seed crop), clover (seed crop), alfalfa
           (including grass mixtures), artichoke  (globe),
           banana, barley, beans (dried-type, succulent), beans-
           lima, blueberries, beets, Brussels sprouts, cabbage,
           carrot, cauliflower, citrus fruits, clover (including
           grass mixtures), collards, corn (field, pop, sweet),
           cotton, flax, lettuce, oats, pasture grass, peanuts,
           peas (field: blackeyed, cowpeas, crowder, southern),
           peppers, pumpkin, rangeland grasses, safflower,
           soybeans (seed crop), sugar beets, tomato, wheat;
           also:  field crops, truck crops (field borders).

        0  Terrestrial, non-domestic, non-food uses on:

           tobacco, ornamental evergreens (including pine),
           shade trees, woody shrubs and vines, herbaceous
           plants (including annuals, aster, chrysanthemum,
           daisy, iris, and nursery stock), lawns, turf,
           recreational areas (including picnic areas).

        0  Aquatic, non-food uses on:  bait fish, gold fish.

        0  Domestic outdoor uses on:  ornamental  lawns,
           domestic dwellings (outdoor).

        0  Forestry uses:  forest trees.

        0  Greenhouse,  food uses on: cucumbers, peppers,
           spinach, beets (root crop), beans (lima, green and
           wax), corn (sweet and field), peas.  These uses
           are from a 24 (c) label restricting applic?.tions to
           research crops.
                                 17

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        0  Greenhouse, non-food use on:

           Weed hosts of plant pathogens.  This use is from a
           24(c) label.

        0  Indoor uses:

           Dairy cattle (non-lactating), beef cattle, horses,
           dairy barns (including manure and garbage dump
           treatment), milking rooms including manure and
           garbage dump treatment, animal buildings and
           premises (including barns, shelters, stables,
           feedlots, holding pens, manure and garbage dump
           treatment), animal hospitals, cat quarters, dog
           quarters (including kennels), dogs, domestic
           dwellings,  garbage dumps, latrines, recreational
           areas (including picnic areas), poultry packing
           plants,  red meat packing plants, commercial,
           institutional,  and industrial areas (inedible
           product areas), eating establishments (inedible
           product areas), food processing, handling and
           storage plants/areas (inedible product areas).


The attached "EPA Index to Registered Pesticides" entry summarizes

all currently acceptable uses for single active ingredient

products containing trichlorfon, including sites of application,

target pests, dosage rates, restrictions and limitations, and

the method and frequency of application.


        c.  Precautionary Statements


Labels for all MP products containing trichlorfon must bear

statements reflecting the hazards to man and the environment

[40 CFR 162.10].  Trichlorfon is in Toxicity Category II on

the basis of acute oral effects and Category III on the basis

of acute dermal effects.  The Agency has no valid acute inhala-

tion, primary eye,  primary dermal, or dermal sensitization data

for trichlorfon MP products.
                                18

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        0  Based on data reviewed by the Agency, the environ-

           mental hazard statement below is required to

           appear on all MPs containing trichlorfon:

             "This pesticide is toxic to fish and wildlife
              and is extremely toxic to aquatic invertebrates.
              Do not discharge effluent containing this product
              into lakes, streams, ponds, estuaries, oceans, or
              public waters unless this product is specifically
              identified and addressed in an NPDES permit.  Do
              not discharge effluent containig this product to
              sewer systems without previously notifying the
              sewage treatment plant authority.  For guidance
              contact your State Water Board or Regional Office
              of the EPA."

    2.   Label Requirements for End-Use Products


        a.  Ingredient Statement


The ingredient statement for EPs must list the active

ingredient as:

         dimethyl-[2,2,2-trichloro-1-hydroxyethyl]
           phosphonate		% .
        b.  Precautionary Statements


Labels for all EPs containing trichlorfon must bear a

statement reflecting the hazard to man and the environment

[40 CFR 162.10] .


        0  Based on data reviewed by the Agency, the following

           environmental hazards statements are required to

           appear on the EPs:

           All trichlorfon products intended for outdoor use
           must bear the following statement:

               "This pesticide is toxic to fish and wildlife
                and is extremely toxic to aquatic invertebrates."
                                  19

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   Additional precautionary statements are required
   as indicated below:

   Trichlorfon products intended for direct applications
   to ponds:

       "Consult your State Fish and Game Agency
        before applying this product to public
        waters.  Permits may be required before
        treating such waters."

   Trichlorfon products intended for use in forestry;

       "Do not apply directly to water or wetlands
        not under forest canopy.  Runoff and drift
        from treated areas may be hazardous to aquatic
        organisms in neighboring areas."

   Trichlorfon products intended for outdoor uses other
   than direct applications to ponds or forestry;

       "Do not apply to water or wetlands.  Run-
        off from treated areas may be hazardous to
        aquatic organisms in neighboring areas."
   The Agency is currently considering various approaches

   to address the endangered species concerns for this

   and other chemicals.   This standard may be amended

   to incorporate the results of this additional review.



0  To avoid the possible misuse of trichlorfon in eating

   establishments the following statement is required

   for all EPs used in eating establishments.
     "This product shall not be used in rooms or areas
      where food is either consumed or prepared."
   Bee precautionary language per PR Notice 68-19 is no

   longer required since the data indicates that

   trichlorfon has a low toxicity to bees.
                        20

-------
        0  The reentry statement below must appear on all

           trichlorfon labels with directions for use on crops:


             "Do not reenter treated fields within 24 hours
              unless protective clothing is worn."


           Refer to PR Notice 83-2 for additional information

           on reentry and worker protection labeling require-

           ments .



H.  TOLERANCE REASSESSMENT


The previously established tolerances for combined residues

of trichlorfon and its cholinesterase-inhibiting metabolites

are published in 40 CFR 561.190 and 40 CFR 180.198.  A summary

of these tolerances is presented in Table 1.


The data for trichlorfon residues in or on the following raw

agricultural commodities are adequate to fill the residue data

requirements:

     beets, blueberries; peanut hulls and vine hay; birdsfoot
     trefoil hay (including chaff); corn grain; fresh corn;
     corn forage and fodder, forage of barley, oats, and
     wheat; bananas; peanuts; and the fat, meat, and meat
     by-products of goats, horses, and sheep.


Sufficient residue data are not available to assess the

adequacy of the trichlorfon tolerances for the following

commodities (and their processed products, if applicable):

     carrots, sugar beets and tops, lettuce, Brussels sprouts,
     cabbage, cauliflower, collards, cowpeas, dried beans,
     lima beans, snap beans, bean vines, cowpea vines, lima
     bean vines and hay, peppers, tomatoes, pumpkins, citrus
     fruits and dried citrus pulp, barley grain and straw,
                                21

-------
     pat grain and straw, wheat grain and straw, pasture and
     rangeland grass forage and hay, alfalfa forage and hay,
     clover forage and hay, artichokes, cottonseed, flax
     seed and straw, safflower seed, cattle (fat, meat, and
     meat by-products), and milk.
Residue data are required for processed products of the

following commodities to determine the necessity of food/feed

additive tolerances:
     citrus fruits; cottonseed; wheat grain; sugar beets;
     and tomatoes.
Residue data for tobacco are required to determine the human

hazard associated with this trichlorfon use.


Poultry residue studies are required to determine the necessity

of trichlorfon tolerances for poultry fat, meat, and meat

byproducts; a tolerance for eggs is not required.


No group crop tolerances are appropriate at the present time.

                                                               I
Residue data and tolerance proposals must be submitted for

the following raw agricultural commodities for which tolerances

are not currently established, but intrastate registrations

exist:

     strawberries; watermelon; broccoli; kale; spinach;
     garlic; onions; radishes; rutabagas; celery; and turnips.


No new crop groupings can be established at this time because

of extensive residue chemistry data gaps.  Compatibility

between Codex MRLs and U.S. tolerances will be assessed when
                                 22

-------
data gaps specified in Table A have been submitted and



evaluated.






The lack of adequate animal and plant metabolism studies



precludes a determination of the trichlorfon residues of



concern in plants and animals.  Before the submission of



additional residue data, it is imperative that the residues



of concern be determined.  The registrant is to conduct



adequate plant and animal metabolism studies prior to



generating residue data so that all the components of the



residue (parent compound and metabolites) can be identified,






The previously established ADI for trichlorfon is 0.1250



mg/kg/day and the TMPC, based on the established tolerances



for residues of trichlorfon as cited under 40 CFR 180.198,




is 0.0627 mg/day assuming a 1.5 kg diet; the TMPC currently



accounts for only 0.84% of the ADI.  No adequate study



currently supports the previously established ADI.  A new



ADI will be established when the chronic toxicity data re-



quirements specified in Table A are satisfied.
                                 23

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           TABLE I.
SUMMARY OF PRESENT TOLERANCES   a/
                         Tolerances  (ppn)
Commodity United States
Alfalfa
Alfalfa, hay
Artichokes
Apples
Bananas
Barley, forage
Barley, grain
Barley, straw
Beans, dried
Beans, lima
Beans, lima vine hay
Beans, lima vines
Beans, blackeyed
Beans , snap
Beans, vines
Beets
Beets, sugar
Beets, sugar tops
Birdsfoot trefoil, hay
Blueberries
Brussels sprouts
Cabbage
Carrots
Cattle fat
Cattle, mbypf/
Cattle, meat
Cattle, offal
Cauliflower
Celery
Cereal grains
Citrus fruit
Citrus (dry pulp)
Cherries
Chili peppers
Chickpeas
Clover
Clover hay
Col lards
Corn, fodder
Corn, forage
Corn, fresh
Corn, grain
Cottonseed
Cowpeas
Cowpeas, vines
60.0
90.0
0.1 (N)V
-
2.o
-------
                                   TABLE I.
                  SUMMARY OF PRESENT TOLERANCES a/(continued)
                                                  Tolerances (ppm)
Commodity

Flax, straw
Flaxseed
Goats, fat
Goats, mbyp
Goats, meat
Grapes
Grass, pasture
Grass, pasture hay
Grass, range
Grass, range, hay
Horses, fat
Horses, mbyp
Horses meat
Kale
Lettuce
Linseed
Milk
Mustard green
Oats, forage
Oats, grain
Oats, straw
Peaches
Peanuts
Peanuts, vine hay
Peanuts, vine hulls
Peppers
Pigs, carcass meat
Pigs, edible offal
Pigs, fat
Pumpkins
Radish
Rapeseed
Rutabagas
Safflower seed
Salisfy
Sheep, fat
Sheep, mbyp
Sheep, meat
Soya, beans
Squash
Spinach
Sugar beets
United
1.
0.
0.
0.
0.
-
60.
90.
240.
240.
0.
0.
0.
0.
0.
-
0.
-
50.
0.
1.
-
0.
4.
4.
0.
-
-
-
0.
-
-
States
0
1
1
1
1

0
0
0
0
1
1
1
1
1

01

0
1
0

05
0
0
1



1



(N)
(N)
(N)
(N)





(N)
(N)
(N)
(N)
(N)

(N)


(N)


(N)


(N)



(N)


Canada Mexico International Codex <
_ ^ .
-
-
-
-
- - 0
- -
- . -
- -
- -
-
-
-
0.1 (N) - 0
0.1 (N) 0.1 (N) 0
- - 0
- - 0
- - 0
- -
- -
-
0
0.05 0
- -
4.0
0.1 (N) - 1
- - 0
- - 0
- - 0
- - 0
- - 0
0.1 (N) - 0
—
-
-
-
-
.5
-
-
-
-
-
-
-
.2
.5
.1
.05
.1
-
-
-
.2
.1
-
-
.0
.1
.1
.1
.1
.1
.1
0.1 (N)
0.1
0.1
0.1
(N)
(N)
(N)
              0.1  (N)

              0.1  (N)
0.1
                               0.1 (N)
0.1
                  0.1 (N)
                  0.1 (N)
                                         0.1

                                         0.5
                                         0.05
                                        25

-------
                                   TABLE I.
                  SUMMARY OF PRESENT TOLERANCES a/  (continued)
                                                  Tolerances (ppm)
Commodity

Stawberries
Tomatoes
Turnips
Wheat, forage
Wheat, grain
Wheat, straw
United States
_^
0.1 (N)
-
50.0
0.1 (N)
1.0
Canada Mexico International Codexg/
^ ^
0.1 (N) 0.1 (N)
0.1 (N)
50.0
0.1 (N)
1.0
1.0
0.2
0.1
-
-
. —
a/  Tolerance is based on residues of trichlorfon and its cholinesterase-
    inhibiting metabolites.

b/  (N) is neglibible residues

£/  NMT 0.2 ppm will be present after peel is removed.

d/  Reflecting 0.1 ppm (N) in or on shelled beans.

e/  MBYP = Meat byproducts

f/  Including sweet K + CWHR.

£/  International Codex "tolerances" are expressed as MRLs or maximum residue
    limits.
                                         26

-------
                               Index of Currently Acceptable Uses**
                                 EPA Index to Pesticide Chemicals

C057901                DIMETHYL (2,2,2-TRICHLORC~l-HYDROXYETHYL)PHOSPHONATE*


            TYPE PESTICIDE;   Insecticide

            FORMULATIONS;
            Tech (90%, 97%,  98%)
            FI   (80%, 82%)
            D    (3%, 5%,  8%)
            G    (0.4%, 0.92%, 1%,  3%,  3.5%,  4%,  5%,  6.2%)
            P/T  (5%, 37.8%, 90%)
            WP/D (37.8%)
            Impr (1%)
            SC/L (4 Ib/gal,  6 Ib/gal, 40.5%)
            SC/S (50%, 80%)
            RTU  (1.5 Ib/gal, 8%)

            GENERAL WARNINGS AND  LIMITATIONS;   Trichlorfon does not significantly af-
            fect beneficial  insects (parasites,  predators, and  pollinators) especially
            when applied at  the minimum recommended rates  per acre.   Trichlorphon is
            not specifically recommended for  the  control of aphids,  cabbage loopers,
            or mites, but  some suppression of these pests  may result from listed  dos-
            ages.  To avoid  plugging, use  50  mesh screens  in sprayers when applying
            soluble concentrate/solid formulations.   Do not use in  conjunction with
            alkaline materials such as  lime or lime sulfur, or  with summer oils or
            dormant oils.
            Definition of  Terms;
            **Computed from  tablespoon/teaspoon dosage.
            ***Exact computation  of actual dosage is  not possible because of the  lack
            of weight/volume information on the label.  Extrapolation from other  for-
            mulations reveals that  the  dosage from this label appears to  fall within
            the range shown  by formulations with  known weight/volume ratios.
            Claims for pest  control limited to suppression of population  are indicated
            by parenthesized pest name.
             *trichlorfon
              Dipterex
              Dylox
              Neguvon
              trichlorphon
            **covers single active  ingredient labeling only

            Issued:  3-22-82               III-057901-1
            Provisional Update:   6-14-84
                                                  27

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                                  EPA  Index  to Pesticide Chemicals

                       DIMETHYL  (2,2,2-mCHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site And Pest
            AGRICULTURAL CROPS
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
            General Warnings and Limitations;   Do not apply to or allow to drift onto
            varieties of sorghum which are sensitive to phosphates as burning of sor-
            ghum or milo may occur.  Injury to foliage and fruit of apples has been
            reported.  For soluble concentrate/liquid formulations, apply per acre
            rates in a minimum of 1 gallon of water per acre by aircraft or ground
            equipment or apply undiluted by aircraft or ultra low volume ground equip-
            ment.  For soluble concentrate/solid formulations, apply in sufficient
            water for thorough coverage by aircraft or ground equipment.
/23001AA
/28069AA
Alfalfa
Alfalfa-Grass Mixture
ITBJADA
  Alfalfa caterpillar 0.375-0.5
                       Ib/A
                      (4-6 Ib/gal
                       SC/L)
                      (40.5%
                       SC/L)***
                      (50-80% SC/S)
60 ppm  (fresh)
90 ppm  (hay)
No pregrazlng or preharvest Interval
through 1 pound per acre of dilute
spray formulations for foliar appli-
cation.  Do not make more than 3 ap-
plications per cutting.
3 day pregrazlng or preharvest in-
terval  through 1 pound per acre of
ultra low volume spray formulations
for foliar application.  Do not make
more than 1 application per cutting.
7 day pregrazing or preharvest in-
terval  through 1 pound per acre of
dust formulations for foliar appli-
cation.  Do not make more than 1 ap-
plication per cutting.
14 day  pregrazing or preharvest in-
terval  through 1 pound per acre of
bait formulations for broadcast soil
application.  Do not make more than
1 application per cutting.
Use patterns for spray formulations
include alfalfa in mixed stands with
grasses.

Foliar application.  May be applied
by aircraft.  Some 4 pounds per gal-
lon soluble concentrate/liquid for-
mulations may be applied undiluted
as an ultra low volume spray by air-
craft or ground equipment.
            Issued:   3-22-82
                             III-057901-2
                                                 28

-------
ITBMBUA
IQAMABA
ITBCCFA
IQAMARA
IQAQAAA

ITBCCNA
IRAFAAA
ITBCCBA
ITBCCRA
/23001AA
ITBJADA
ITBMBUA
ITBCCNA
IQAMARA
IQAQAAA
ITBCCBA
ITBCCRA
ITBCCFA
ITBCCNA
IVAHAAA

ITBCABA
                                 EPA Index to Pesticide Chemicals

                        DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

            Site and Pest           Dosages and   Tolerance. Use, Limitations
                                    Formulation(s)

              Alfalfa cluster (continued)
Alfalfa webworm
Alfalfa plant bug
Armyworm
Lygus bugs (includ-
 ing tarnished
 plant bug)
Stink bugs

Beet armyworm
Leaf hoppers
Variegated cutworm
Western yellow-
 striped armyworm
                    0.25-1 Ib/A
                    (4-6 Ib/gal
                     SC/L)
                    (40.5%
                     SC/L)***
                    (50-80% SC/S)

                    1 Ib/A
                    (4-6 Ib/gal
                     SC/L)
                    (40.5%
                     SC/L)***
                    (50-80% SC/S)

                    0.5-1 Ib/A
                    (4-6 Ib/gal
                     SC/L)
                    (40.5%
                     SC/L)***
                    (50-80% SC/S)

                    0.5 Ib/A
                    (4-6 Ib/gal
                     SC/L)
                    (40.5%
                     SC/L)***
                    (50-80% SC/S)
   (Alfalfa)
Alfalfa caterpillar 0.9-1 Ib/A
Alfalfa webworm
Beet armyworm
Lygus bugs (includ-
 ing tarnished
 plant bug)
Stink bugs
Variegated cutworm
Western yellow-
 striped armyworm
                    (3-8% D)
Foliar application.
by aircraft.
                                                       May be applied
                    1 Ib/A
                    (5% D)
                    (3-5% G)
Armyworm
Beet armyworm
Crickets (including [Bait]
 mole crickets)
Cutworms (climbing
 and surface feed-
 ing including
Broadcast soil application.  May be
applied by aircraft.  For fields
with previous infestations or sus-
pected infestations of cutworms,
apply prior to or just after plant-
ing.
            Issued:  3-22-82
                           III-057901-3
                                                  29

-------
ITABACA

ITBCCRA


ITBCCFA
/23001BA
/23003BA
ITBCCFA
IQAMARA
IQAQAAA
ITBCCBA
/13018AA
ITBLABA
                                  EPA Index  to  Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HyDROXYETHYL)PHOSPHONATE
            Site and Pest
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
Alfalfa cluster (continued)

  Pest list continued from previous page.

   black cutworm,
   granulate cut-
   worm, variegated
   cutworm, western
   bean cutworm)
  Saltmarsh cater-
   pillar
  Western yellow-
   striped army worm
  Armyworm
Alfalfa (seed crop)
Clover (seed crop)
1 Ib/A
(5% P/T)
[Bait]
Broadcast soil application.  Make 1
application per cutting.
  Armyworm
  Lygus bugs
  Stink bugs
  Variegated cutworm  (40.5%
                       SC/L)***
                      (50-80% SC/S)

Alfalfa-Grass Mixture See Alfalfa cluster.
              90 ppm (hay)
              7 day prehervest interval through
              1.5 pounds per acre for foliar ap-
              plication.
              Do not cut green crop for feed or
              forage.  Chaff may be used for feed
              or forage.

1-1.5 Ib/A    Foliar application to seed crop.
(4-6 Ib/gal   May be applied by aircraft.
 SC/L)
Artichoke (Globe)
  Artichoke plume
   moth
2-2.5 Ib/A
(5-8% D)
0.1 ppm
14 day preharvest interval through
2.5 pounds per acre for foliar ap-
plication.

Foliar application.  May be applied
by aircraft.
            Issued:   3-22-82
                             III-057901-4
                                                 30

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                                 EPA Index to Pesticide Chemicals
/06002AA
I1AJACA
/28063AA
/28009AA
/28062AA
/28065AA
ITBCCFA
IVAHAAA
ITABACA

ITBCABA
ITBCCFA
ITBCCNA
ITBMBWA
ITBCCBA
ITBCBVA
ITBWAFA
           DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

Site and Pest           Dosages and   Tolerance. Use, Limitations
                        Formulation(s)

  Banana                              2 ppm
                                      0.2 ppm (in pulp after peel is re-
                                      moved)
                                      No preharvest interval through 0.5
                                      pound per acre for foliar applica-
                                      tion.

    Banana caterpillar  0.4-0.5 Ib/A  Foliar application.  Repeat at 14
                        (80% SC/S)    day intervals as needed.

                                      0.1 ppm (grain and flazseed)
                                      1 ppm (straw)
                                      50 ppm (barley, oats and wheat
                                      forage)
                                      21 day preharvest interval through 1
                                      pound per acre for foliar applica-
                                      tion or soil application (broad-
                                      cast).  For spray formulations, do
                                      not make more than 3 applications
                                      during the growing season.   Applica-
                                      tions may be made without removal of
                                      livestock.
                                      For bait formulations, do not graze
                                      treated fields.  Do not feed treated
                                      straw to dairy or meat animals.
    Armyworm
    Crickets
    Saltmarsh cater-
     pillar
    Cutworms (climbing
     and surface
     feeding)

    Armyworm
    Beet armyworm
    Beet webworm
    Variegated cutworm
    Bertha armyworm
    Diamondback moth
1 Ib/A
(5% D)
(4-5% G)
[Bait]
0.5-1 Ib/A
(4-6 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)

1 Ib/A
(4-6 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)
Broadcast soil application.  May be
applied by aircraft.  For fields
with previous infestations or sus-
pected infestations of cutworms,
apply prior to or just after plant-
ing.
Foliar application.
by aircraft.
May be applied
            Issued:  3-22-82
                               III-057901-5
                                                 31

-------
/15001AA
/15003AA
/15025AA
ITBCCFA
IOAAAEA

IQAMARA
INAPAFA
IQAQAAA
ITBCCBA

ITBCBTA
ITBCCFA
ITBCCNA
IVAHAAA

ITBCBAA
INBUAAA
ITABACA

ITBCCRA
                                 EPA  Index to Pesticide  Chemicals

                        DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXyETHYL)PHOSPHONATE
            Site and Pest
Beans, Dried-Type
Beans, Succulent
Dosages and   Tolerance, Use, Limitations
Formulatlon(s)

              0.1 ppm (beans, dried and snap)
              1 ppm (vines)
              14 day preharvest interval through
              1.5 pounds per acre for foliar ap-
              plication or soil application (band
              or broadcast).
              Do not feed treated vines to dairy
              or meat animals.
  Armywonn            1-1.5 Ib/A
  Dipterous leaf-     (3-8% D)
   miners             (4-6 Ib/gal
  Lygus bugs           SC/L)
  Mexican bean beetle (40.5%
  Stink bugs           SC/L)***
  Variegated cutworm
  Western bean cut-
   worm
  Armyworm            1.5 Ib/A
  Beet armyworm       (5% D)
  Crickets (including (3.5-5% G)
   mole crickets)     [Bait]
  Cutworms (climbing
   and surface feed-
   ing including
   black cutworm,
   granulate cut-
   worm, variegated
   cutworm, western
   bean cutworm)
  Darkling beetles
  Saltmarsh cater-
   pillar
  Western yellow-
   striped armyworm
              Foliar application.
              by aircraft.
May be applied
(50-80% SC/S)

1-1.5 Ib/A
(3-8% D)
  or
0.5-1 Ib/A
(4-6 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)
              Soil application (band).  Apply over
              the row and around base of plants.

              Broadcast soil application.  May be
              applied by aircraft.  For fields
              with previous infestations or sus-
              pected infestations of cutworms,
              apply prior to or just after plant-
              ing*
            Issued:   3-22-82
                             III-057901-6
                                                    32

-------
                                 EPA Index to Pesticide Chemicals
                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
/15025AA
/15025CA

/15003CA

/14001CA

/28005CA

/15005CA

/10010CA

/2801bCA

/28017CA

/13024CA
            Site and Pest
Beans, Lima
Dosages and   Tolerance, Use, Limitations
Formulation(s)

              12 ppm (beans [reflecting 0.1 ppm
              in or on the shelled beans], bean
              vines, bean vine hay)
              14 day preharvest interval through
              1.5 pounds per acre for foliar ap-
              plication.
              30 day preharvest interval through
              1.5 pounds per acre of bait formula-
              tions for soil application (band or
              broadcast).
              Do not make more than 2 applications
              during the growing season.

Refer to Beans, Dried-Type cluster.
Beans, Lima
 (greenhouse research
Beans, Succulent
 (greenhouse research
Beets (root crop)
 (greenhouse research
Corn, Field
 (greenhouse research
Corn, Sweet
 (greenhouse research
Cucumbers
 (greenhouse research
Peas
 (greenhouse research
Peppers
 (greenhouse research
Spinach
 (greenhouse research
              N.F.
crops)

crops)

crops)

crops)

crops)

crops)

crops)

crops)

crops)
                                                  This use only occurs on Special
                                                  Local Need (24(C))  labeling  and  has
                                                  not been included in this entry.
                                                  Refer to appropriate labeling for
                                                  use information and limitations.
              Beans,  Succulent
                      See Beans, Dried-Type cluster.
            Issued:  3-22-82
                             III-057901-7
                                                    33

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                                  EPA  Index  to Pesticide  Chemicals
                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONAIE
/14001AA
ITBMBUA
ITBCCNA
ITBMBWA
IOAAAEA

IQAMARA
ITABACA

ITBCCBA

ITBMBUA
ITBMBWA
IOAAAEA

ITABACA
ITBCCNA
IQAMARA
ITBCCBA
            Site and Pest
Beets
  Alfalfa webworm
  Beet armyworm
  Beet webworm
  Dipterous leaf-
   miners
  Lygus bugs
  Saltmarsh cater-
   pillar
  Variegated cutworm

  Alfalfa webworm
  Beet webworm
  Dipterous leaf-
   miner
  Saltmarsh cater-
   pillar

  Beet armyworm
  Lygus bugs
  Variegated cutworm
Dosages and   Tolerance, Use, Limitations
Formulatlon(s)

              0.1 ppm
              28 day preharvest interval through
              1.5 pounds per acre for foliar ap-
              plication or soil application (band
              or broadcast).
              Do not harvest tops for food.
1-1.5 Ib/A
(3-8% D)
Foliar application.
by aircraft.
May be applied
1 Ib/A
6 Ib/gal
 SC/L)
(50-SOZ SC/S)
1-1.5 Ib/A
(6 Ib/gal
 SC/L)
(50-80% SC/S)

0.5-1 Ib/A
(6 Ib/gal
 SC/L)
(50-80% SC/S)
            Issued:   3-22-82
                             III-057901-8
                                                   34

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 ITBCCFA
 IVAHAAA
•ITABACA

 ITBCCXA
                      EPA  Index  to Pesticide Chemicals

            DIMETHYL (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

Site and Pest           Dosages and   Tolerance, Use,  Limitations
                        Formulation(s)

  Beets (continued)

    Armyworm            1.5 Ib/A      Soil application (band).  Apply over
    Crickets            (5% D)        the row and around base of plants.
    Saltmarsh cater-    (3-5% G)
     pillar             [Bait]        Broadcast soil application.  May be
    Surface feeding                   applied by aircraft.  For fields
     cutworms                         with previous infestations or sus-
                                      pected infestations of cutworms,
                                      apply prior to or just after plant-
                                      ing.

  Beets (root crop)
 (greenhouse research crops)
                        See Bean, Lima (greenhouse research crops)
                        cluster.
 /23011BA
  Birdsfoot trefoil (seed crop)
 /01009AA
  Blueberry
 /13006AA
 /13007AA
 /13008AA
 ITBWAFA
 ITBJAHA

 ITBCCBA
 I1BCCRA
  Brussels Sprouts
  Cabbage
  Cauliflower
    Diamondback moth
    Imported cabbage-
     worm
    Variegated cutworm
    Western yellow-
     striped armyworm
1 Ib/A
(3-8% D)
              90 ppm (hay)

              This use only occurs on Special
              Local Need (24(C)) labeling and has
              not been included in this entry.
              Refer to appropriate labeling for
              use information and limitations.

              0.1 IN) ppm

              This is a new use established sub-
              sequent to the development of this
              entry.  Refer to appropriate label-
              ing for use information and limita-
              tions.

              0.1 ppm
              21 day preharvest interval through 1
              pound per acre for foliar applica-
              tion or soil application (band or
              broadcast).
Foliar application.
by aircraft.
May be applied
             Issued:   3-22-82
                               III-057901-9
                                                    35

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                                 EPA Index to Pesticide Chemicals

                        DIMETHYL  (2,2,2-mCHLORO-l-HYDROXYETHYL)PHOSPHONATE

            Site and Pest           Dosages and   Tolerance, Use, Limitations
                                    Formulation(s)

              Brussels Sprouts cluster (continued)

ITBJAHA         Imported cabbage-   0.5-1 Ib/A
                 worm               (6 Ib/gal
ITBCCBA         Variegated cutworm   SC/L)
                                    (50-80% SC/S)

ITBCCRA         Western yellow-     0.5 Ib/A
                 striped armyworm   (6 Ib/gal
                                     SC/L)
                                    (50-60% SC/S)

ITBCCFA         Armyworm            1 Ib/A        Soil application (band).   Apply over
ITBCCNA         Beet armyworm       (5% 0)        the row and around base of plants.
IVAHAAA         Crickets (including (3-5% G)
                 mole crickets)     [Bait]        Broadcast soil application.  May be
ITBCABA         Cutworms (climbing                applied by aircraft.  For fields
                 and surface feed-                with previous Infestations or sus-
                 ing including                    pected infestations of cutworms,
                 black cutworm,                   apply prior to or just after plant-
                 granulate cut-                   ing.
                 worm, variegated
                 cutworm, western
                 bean cutworm)
ITABACA         Saltmarsh cater-
                 pillar
ITBCCRA         Western yellow-
                 striped armyworm
            Issued:   3-22-82                III-057901-lO
                                                    36

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/14003AA
ITBCCNA
IOAAAEA

IQAMARA
ITABACA

ITBCCBA
ITBCCRA
ITBCCNA
IQAMARA
IOAAAEA
ITBCCBA
ITABACA
                                 EPA Index to Pesticide Chemicals

                        DIMETHYL  (2,2,2-TRICHLORO-l^IYDROXYETHYL)PHOSPHONATE

            Site and Pest
Carrot
  Beet armyworm
  Dipterous leaf-
   miners
  Lygus bugs
  Saltmarsh cater-
   pillar
  Variegated cutworm
  Western yellow-
   striped armyworm

  Beet armyworm
  Lygus bugs
  Dipterous leaf-
   miners
Dosages and   Tolerance, Use, Limitations
Formulation(s)

              0.1 ppm
              28 day prebarvest interval through
              1.5 pounds per acre for foliar ap-
              plication.
              Do not harvest tops for food or
              feed.
1-1.5 Ib/A
(3-5% D)
Foliar application.
by aircraft.
May be applied
1-1.5 Ib/A
6 Ib/gal
 SC/L)
(50-80% SC/S)

1 Ib/A
6 Ib/gal
 SC/L)
(50-80% SC/S)
  Variegated cutworm  0.5-1 Ib/A
                      (6 Ib/gal
                       SC/L)
                      (50-80% SC/S)
  Saltmarsh cater-
   pillar
1.5 Ib/A
(6 Ib/gal
 SC/L)
(50-80% SC/S)
            Issued:  3-22-82
                             III-057901-ll
                                                    37

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

            Site and Pest           Dosages and   Tolerance, Use, Limitations
                                    Formulation(s)

              Carrot (continued)

ITBCCRA         Western yellow-     0.5 Ib/A
                 striped armyworm   (6 Ib/gal
                                     SC/L)
                                    (50-80% SC/S)

              Cauliflower           See Brussels Sprouts cluster.

/02000AA      Citrus Fruits                       0.1 ppm
                                                  2.5 ppm (in dried citrus pulp)
                                                  7 day preharvest interval through 4
                                                  pounds per acre for foliar applica-
                                                  tion.  Apply only 1 application by
                                                  aircraft.
                                                  21 day preharvest interval through 4
                                                  pounds per acre for foliar applica-
                                                  tion.  Do  not make more than 3 ap-
                                                  plications during the fruiting peri-
                                                  od, 1 by aircraft and not more than
                                                  2 additional applications by ground
                                                  equipment.
                                                  Apply in a minimum of 1 gallon of
                                                  water per  acre  by aircraft or in 200
                                                  to 250 gallons  of water per acre by
                                                  ground equipment.

ITAPAJA         Avocado leafroller   4  Ib/A        Use limited to  CA.
ITBCCUA         Citrus cutworm      (50-80% SC/S) Foliar application.
ITANAXA         Citrus looper
ITBUALA         Orange tortrix

ITBHAFA         Black swallowtail   2  Ib/A
ITBUAGA         Fruittree leaf-     (50-80% SC/S)
                 roller
ITBUBCA         Omnivorous leaf-
                 roller
            Issued:  3-22-82               111-057901-12
                                                    38

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                                  EPA Index  to  Pesticide  Chemicals
                        DIMETHYL (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
/23003AA
/28079AA
            Site and Pest
Clover
Clover-Grass Mixture
Dosages and   Tolerance, Use, Limitations
Formulation(s)

              60 ppm (fresh)
              90 ppm (hay)
              No pregrazlng or preharvest interval
              through 1 pound per acre of spray
              formulations for foliar application.
              Do not make more than 3 applications
              per cutting.
              7 day pregrazing or preharvest in-
              terval through 1 pound per acre of
              dust formulations for foliar appli-
              cation.
              Use patterns for spray formulations
              include clover in mixed stands with
ITBJADA
  Alfalfa caterpillar 0.375-0.5
                       Ib/A
                      (4-6 Ib/gal
                       SC/L)
                      (40.5%
                       SC/L)***
              grasses.

              Foliar application.
              by aircraft.
May be applied
ITBMBUA
  Alfalfa webworm
ITBCCFA
IQAMABA
IQAMARA
IQAQAAA

ITBCCNA
IRAFAAA
ITBCCBA
ITBCCRA
  Armyworm
  Alfalfa plant bug
  Lygus bugs (includ-
   ing tarnished
   plant bug)
  Stink bugs

  Beet armyworm
  Leafhoppers
  Variegated cutworm
  Western yellow-
   striped armyworm
(50-80% SC/S)

0.25-1 Ib/A
(4-6 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)

1 Ib/A
(4-6 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)

0.5-1 Ib/A
(4-6 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)

0.5 Ib/A
(4-6 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)
            Issued:  3-22-82
                             III-057901-13
                                                      39

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                                  EPA Index  to  Pesticide Chemicals

                        DIMETHYL (2,2,2-TRICHLORO-l-HYDROXyETHYL)PHOSPHONATE
            Site and Pest
/23003AA
ITBJADA
ITBMBUA
ITBCCNA
IQAMARA
IQAQAAA
ITBCCBA
ITBCCRA
ITBCCFA
/13009AA
/13020AA
ITBCCFA
ITBMBWA
1TBWAFA
IOAAAEA

ITABACA
IMQAAAA
ITBCCBA
                      Dosages and   Tolerance, Use, limitations
                      Formulation(s)
Clover cluster (continued)

     (Clover)
  Alfalfa caterpillar 1 Ib/A
  Alfalfa webworm     (5-8% D)
  Beet armyworm
  Lygus bugs (Includ-
   ing tarnished
   plant bug)
  Stink bugs
  Variegated cutworm
  Western yellow-
   striped armyworm
              Foliar application.  May be applied
              by aircraft.
  Armyworm
1 Ib/A
(5% P/T)
[Bait]
Broadcast soil application.  Make 1
application per cutting.
              Clover (seed crop)    See Alfalfa (seed crop) cluster.

              Clover-Grass Mixture  See Clover cluster.
Collards
Lettuce
              0.1 ppm
              28 day preharvest interval through 1
              pound per acre for foliar applica-
              tion or soil application (band or
              broadcast).
              For lettuce, do not apply after
              heads begin to form.
  Armyworm
  Beet webworm
  Diamondback moth
  Dipterous leaf-
   miners
  Saltmarsh cater-
   pillar

  Thrips
  Variegated cutworm
1 Ib/A
(3-8% D)
(6 Ib/gal
 SC/L)
(50-60% SC/S)
1 Ib/A
(3-8% D)
  or
0.5-1 Ib/A
(6 Ib/gal
 SC/L)
(50-80% SC/S)
Foliar application.
by aircraft.
May be applied
            Issued:   3-22-82
                             111-057901-14
                                                   40

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONAIE

            Site and Pest           Dosages and   Tolerance. Use, Limitations
                                    Formulation(s)
              Collards cluster (continued)

ITBCCFA         Armyworm            1-1.5 Ib/A
ITBCCNA         Beet armyworm       (5Z D)
IVAHAAA         Crickets (including (3-52 6)
                 mole crickets)     [Bait]
ITBCABA         Cutworms (climbing
                 and surface feed-
                 ing including
                 black cutworm,
                 granulate cut-
                 worm, variegated
                 cutworm, western
                 bean cutworm)
INBUAAA         Darkling beetles
ITABACA         Saltmarsh cater-
                 pillar
ITBCCRA         Western yellow-
                 striped armyworm

/28006AA      Corn. Field
/15004AA      Corn. Pop
/15005AA      Com. Sweet
       Soil application (band).  Apply over
       the row and around base of plants.

       Broadcast soil application.  May be
       applied by aircraft.  For fields
       with previous infestations or sus-
       pected infestations of cutworms,
       apply prior to or just after plant-
       ing.
       0.1 ppm (corn grain including pop-
       corn, fresh corn including sweet
       corn [kernels plus cob with husk re-
       moved])
       30 ppm (fodder, forage)
       No preharvest interval through 1
       pound per acre of spray formulations
       for foliar and soil applications.
       Do not make more than 3 applications
       during the growing season.
       28 day preharvest interval through 1
       pound per acre of 80 percent soluble
       concentrate/solid formulation for
       food, feed, or ensilage for foliar
       and soil applications.
       40 day preharvest interval through 1
       pound per acre of bait formulations
       for feed, food, or ensilage for soil
       application (band or broadcast).  Do
       not make more than 1 application
       during the growing season.
            Issued:  3-22-82
111-057901-15
                                                   41

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ITBCCFA
IVAHAAA
ITBCABA
INBUAAA
ITABACA
ITBCCFA
ITBCABA
                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
                        Dosages and   Tolerance,  Use,  Limitations
                        Formulation(s)
              Corn, Field cluster (continued)
    Armyworm
    Crickets
    Cutworms (climbing
     and surface
     feeding)
    Darkling beetles
    Saltmarsh cater-
     pillar
    Armyworm
    Cutworms
1 Ib/A
(5% D)
(3-5% G)
[Bait]
Soil application (band).  Apply over
the row and around base of plants.

Broadcast soil application.  May be
applied by aircraft.  For fields
with previous infestations or sus-
pected infestations of cutworms,
apply prior to or just after plant-
ing.
0.5-1 Ib/A    Foliar and soil application.  For
(4-6 Ib/gal   early applications, when plants are
 SC/L)        3 to 12 inches high, direct spray to
(40.5%        lower portion of plants and to the
 SC/L)***     soil around the base of plants.
(50-80% SC/S) Later applications may be made as
              full coverage sprays.
              Corn,  Field
               (greenhouse research crops)
                                    See Bean,  Lima (greenhouse research crops)
                                    cluster.
/28007AA
ITBCCNA
IQAMBFA

IQAMAYA
ITAYAHA

I1BCAOA
              Corn,  Sweet
               (greenhouse research crops)
                                    See Bean,  Lima (greenhouse research crops)
                                    cluster.
  Cotton
    Beet armyworm
    Black cotton flea-
     hopper complex
    Cotton fleahopper
    Cotton leafperfor-
     ator
    Cotton leafworm

Issued:   3-22-82
0.9-1.5 Ib/A
(3-8% D)
0.1 ppm (cottonseed)
7 day preharvest interval through
1.5 pounds per acre for foliar ap-
plication or soil application (band
or broadcast).
14 day pregrazing interval through
1.5 pounds per acre for foliar ap-
plication or soil application (band
or broadcast).
May cause marginal leaf burn.  In-
jury may occur if application is
made while foliage is wet.

Foliar application.  May be applied
by aircraft.  For beet armyworm,
cotton leafworm, and western yellow-
striped armyworm, apply the lower
rate.  For other pests, apply the
range.
                                           111-057901-16
                                                    42

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                                  EPA  Index  to Pesticide  Chemicals
                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
INBUAAA
IMAAAEA
IQAMARA
ITABACA

IRAFALA

IQAQAAA
ITBCCRA
ITBCCFA
ITBCCNA
IVAHAAA

ITBCABA
ITABACA

1TBCCRA
ITBCCNA
IRAFALA
IQAMBFA

ITAYAHA

IMAAAEA
IQAMARA
IQAQAAA
            Site and Pest
              Cotton (continued)
                    Dosages and   Tolerance, Use, Limitations
                    Formulation(s)
Pest list continued from previous page.

Darkling beetles
Leafrollers
Lygus bugs
Saltmarsh cater-
 pillar
Southern garden
 leafhopper
Stink bugs
Western yellow-
 striped armyworm
Armyworm            1.5 Ib/A
Beet armyworm       (5% D)
Crickets (including (3-5% G)
 mole crickets)     [Bait]
Cutworms (climbing
 and surface feed-
 ing including
 black cutworm,
 granulate cut-
 worm, variegated
 cutworm, western
 bean cutworm)
Saltmarsh cater-
 pillar
Western yellow-
 striped armyworm
              Soil application (band).   Apply over
              the row and around base of plants.

              Broadcast soil application.  May be
              applied by aircraft.  For fields
              with previous infestations or sus-
              pected infestations of cutworms,
              apply prior to or just after plant-
              ing.
Beet armyworm
Southern garden
 leafhopper
Black cotton flea-
 hopper complex
Cotton leafperfor-
 ator
Leafrollers
Lygus bugs
Stink bugs
1 Ib/A
(4 Ib/gal
 SC/L)
(40.5%
 SC/L)***
Foliar application.  May be applied
by aircraft.  For cotton fleahopper,
apply lower rate for light to moder-
ate infestation.  Higher rates may
be required if heavy infestation or
(50-80% SC/S) migration occurs.

1-1.5 Ib/A
(4 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)
            Issued:  3-22-82
                           111-057901-17
                                                  43

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                                 EPA Index  to Pesticide  Chemicals
                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
IQAMAYA
ITBCAOA
INBUAAA
ITBCCRA
ITABACA
IQAMAYA
IQAMARA
/28049AA
/28052AA
ITBCCFA
IVAHAAA
ITABACA

ITBCCXA
            Site and Pest
Cotton (continued)

  Cotton fleahopper
  Cotton leafworm
  Darkling beetles
  Western yellow-
   striped army worm
  Saltmarsh cater-
   pillar
  Cotton fleahopper
  Lygus bugs
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
0.25-1 Ib/A
(4 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)

0.5-1 Ib/A
(4 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)

1.5 Ib/A
(4 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)

0.25-0.5 Ib/A Ultra low volume foliar application.
(4 Ib/gal     Apply by aircraft or ground equip-
 SC/L)        ment.
              Cucumbers
               (greenhouse research crops)
                                    See Bean,  Lima (greenhouse research crops)
                                    cluster.
Field Crops
Truck Crops
  Armyworm
  (Crickets)
  Saltmarsh cater-
   pillar
  Surface feeding
   cutworms
              Flax

              Lettuce

              Oats

            Issued:  3-22-82
              N.F.
              Applications should be made to the
              soil, away from, and not in contact
              with the crop.

7.5 lb/       Soil application to field borders
 1,000 ft     (band).  To control migrating cater-
(5% D)        pillars, place a band 6 inches wide
(4-5% G)      and 0.125 to 0.25 inch deep around
              the field to be protected.  Use in
              conjunction with an aluminum or
              fiber strip barrier.

See Barley cluster.

See Collards cluster.

See Barley cluster.

       111-057901-18
                                                  44

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                                  EPA Index to Pesticide Chemicals
                        DIMETHYL (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
./23035AA
 /28045AA
             Site and  Pest
Pastures (grass)
 ITBCCFA
 ITBCCOA
  Armywoim
  Fall armyworm
 ITBCCFA
 ITBCCOA
 IQAMAAA
 IRAFAAA
 ITBNAJA
 ITBNAJC
  Armyworm
  Fall armyworm
  Plant bugs
  Leafhoppers
  Range caterpillar
  Range caterpillar
   (larvae)
Dosages and   Tolerance, Use, Limitations
Formulation(s)

              60 ppm (fresh)
              90 ppm (hay)
              No preharvest interval through 1
              pound per acre for foliar applica-
              tion.  Do not make more than 3 ap-
              plications per cutting or per grow-
              ing season if crop is not cut for
              hay.
              No preharvest interval through 1
              pound per acre for ultra low volume
              application.  Do not make more than
              1 application per cutting if crop is
              not cut for hay, except that a sec-
              ond application may be made at 0.25
              to 0.5 pound per acre, if needed.
              Do not apply more than a total of 1
              pound per acre in a single growing
              season on crops not cut for hay.
              Applications may be made without re-
              moval of grazing livestock.
0.25-1 Ib/A
(4 Ib/gal
 SC/L)
1 Ib/A
(4 Ib/gal
 SC/L)
(50-80% SC/S)

0.5-1 Ib/A
(4 Ib/gal
 SC/L)
(50-80% SC/S)
Foliar application.  Dosage recom-
mended for Southeast and South Cen-
tral States.  May be applied by air-
craft.  Apply higher rate when In-
festation is heavy and/or the larvae
are in the late instar stages of
growth.

Foliar application.  May be applied
by aircraft.  Some 4 pounds per gal-
lon soluble concentrate/liquid for-
mulations may be applied undiluted
as an ultra low volume spray by air-
craft or ground equipment.
0.25-0.5 Ib/A Use limited to NM.
(4 Ib/gal     Foliar application.  May be applied
                                      SC/L)
                                    by aircraft.   May be applied undi-
                                    luted as an ultra low volume spray
                                    by aircraft or ground equipment.
                                    Apply during  first through third
                                    instars only.
             Issued:   3-22-82
                             111-057901-19
                                                   45

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                                 EPA Index to  Pesticide  Chemicals
                        DIMETHYL  (2,2,2-mCHLORO-l-HYDROXYETHYL)PHOSPHONATE
/28015AA
ITBCCFA
ITBCCNA
IVAHAAA

ITBCABA
ITABACA

ITBCCRA


/15008AA
ITBCCFA
IOAAAEA

ITBJAHA

IQAMARA
INAPAFA
IQAQAAA
ITBCCBA
ITBCBTA
            Site and Pest
Peanuts
                      Dosages and   Tolerance,
                      Fonnulatlon(s)
                                             Use, Limitations
  Armyworm            1 lb/A
  Beet armyworm       (5% D)
  Crickets (including (4-5% 6)
   mole crickets)     [Bait]
  Cutworms (climbing
   and surface feed-
   ing including
   black cutworm,
   granulate cut-
   worm, variegated
   cutworm, western
   bean cutworm)
  Saltmarsh cater-
   pillar
  Western yellow-
   striped army worm
Peas, Field (blackeyed peas,
 cowpeas, crowder peas, and
 southern peas)
                      1-1.5 lb/A
                      (3-8% D)
                      (4-6 Ib/gal
                       SC/L)
                      (40.5%
                       SC/L)***
                                  0.05 ppm (peanuts)
                                  4 ppm (peanut vine hay and hulls)
                                  No preharvest interval through 1
                                  pound per acre for soil application
                                  (band or broadcast).  Do not make
                                  more than 3 applications before dig-
                                  ging.  One additional application
                                  may be made between digging and har-
                                  vest.

                                  Soil application (band).  Apply over
                                  the row and around base of plants.

                                  Broadcast soil application.  May be
                                  applied by aircraft.  For fields
                                  with previous infestations or sus-
                                  pected infestations of cutworms,
                                  apply prior to or just after plant-
                                  ing.
                                  0.1 ppm (cowpeas)
                                  1 ppm (vines)
                                  14 day preharvest interval through
                                  1.5 pounds per acre for foliar ap-
                                  plication or soil application (band
                                  or broadcast).  Do not make more
                                  than 2 applications during the grow-
                                  ing season.
Armyworm
Dipterous leaf-
 mlners
Imported cabbage-
 worm
Lygus bugs
Mexican bean beetle (50-80% SC/S)
Stink bugs
Variegated cutworm
Western bean cut-
 worm
Foliar application.
by aircraft.
May be applied
            Issued:   3-22-82
                             111-057901-20
                                                  46

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                                  EPA Index to Pesticide Chemicals
                        DIMETHYL (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
ITABACA
ITBCCFA
ITBCCNA
IVAHAAA

ITBCABA
ITABACA

ITBCCRA
/28017AA
IOAAAEA

IOBMATA
IOABADA
ITBCCFA
IVAHAAA
INBUAAA
ITABACA
            Site and Pest
                        Dosages and   Tolerance. Use. Limitations
                        Formulation (s)
              Peas, Field (blackeyed peas, cowpeas, crowder peas, and southern peas)
               (continued)
    Saltmarsh cater-
     pillar
                      1.5 Ib/A
                      (6 Ib/gal
                       SC/L)
                                      Soil application (band).  Apply over
                                      the row and around base of plants.

                                      Broadcast soil application.  May be
                                      applied by aircraft.  For fields
                                      with previous infestations or sus-
                                      pected infestations of cutworms,
                                      apply prior to or just after plant-
                                      ing.
  Armyworm            1-1.5 Ib/A
  Beet armyworm       (5% D)
  Crickets (including (4-5% G)
   mole crickets)     [Bait]
  Cutworms (climbing
   and surface feed-
   ing including
   black cutworm,
   granulate cut-
   worm, variegated
   cutworm, western
   bean cutworm)
  Saltmarsh cater-
   pillar
  Western yellow-
   striped armyworm

Peas
 (greenhouse research crops)
                      See Bean, Lima (greenhouse research crops)
                      cluster.
  Peppers
                                    0.1 ppm
                                    21 day preharvest interval through 1
                                    pound per acre of spray or bait for-
                                    mulations or through 1.25 pounds per
                                    acre of dust formulations of foliar
                                    application or soil application
                                    (band or broadcast).
    Dipterous leaf-
     miners
    Pepper maggot
    Serpentine leaf-
     miner complex
    Armyworm
    Crickets
    Darkling beetles
    Saltmarsh cater-
     pillar

Issued:   3-22-82
                      1-1.25 Ib/A
                      (3-8% D)
                        or
                      1 Ib/A
                      (6 Ib/gal
                       SC/L)
                      (50-80% SC/S)

                      1 Ib/A
                      (5% D)
                      (3.5-5% G)
                      [Bait]
Foliar application.
by aircraft.
May be applied
Soil application (band).   Apply over
the row and around base of plants.

Broadcast soil application.  May be
applied by aircraft.  For fields
                                           111-057901-21
                                                  47

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
ITBCCXA
/10011AA
IQAGAFA
ITBCCBA

IQAGAFA
ITBCCBA
ITBCCFA
ITBCCNA
IVAHAAA

ITBCABA
ITABACA
            Site and Pest
Peppers (continued)

  Surface feeding
   cutworms
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
              with previous infestations or sus-
              pected infestations of surface feed-
              ing cutworms, apply prior to or just
              after planting.
              Peppers
               (greenhouse research crops)
                                    See Bean,  Lima (greenhouse research crops)
                                    cluster.
Pumpkin
              0.1 ppm
              14 day preharvest interval through 1
              pound per acre of spray or bait for-
              mulations or 1.5 pounds per acre of
              dust formulation for foliar applica-
              tion or soil application (band or
              broadcast).  Do not make more than 1
              application during the growing sea-
  Squash bug
  Variegated cutworm

  Squash bug
  Variegated cutworm
              son.

1.25-1.5 Ib/A Foliar application.
(3-8% D)      by aircraft.

1 Ib/A
(6 Ib/gal
 SC/L)
(50-80% SC/S)

0.5-1 Ib/A
(6 Ib/gal
 SC/L)
(50-80% SC/S)
May be applied
  Armyworm            1 Ib/A
  Beet armyworm       (5% D)
  Crickets (including (4-5% G)
   mole crickets)     [Bait]
  Cutworms (climbing
   and surface feed-
   ing Including
   black cutworm,
   granulate cut-
   worm, variegated
   cutworm, western
   bean cutworm)
  Saltmarsh cater-
   pillar
              Soil application (band).  Apply over
              the row and around base of plants.

              Broadcast soil application.  May be
              applied by aircraft.  For fields
              with previous infestations or sus-
              pected infestations of cutworms,
              apply prior to or just after plant-
              ing.
            Issued:   3-22-82
                             111-057901-22
                                                  48

-------
                                  EPA Index  to  Pesticide  Chemicals

                        DIMETHYL (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
              Pumpkin (continued)
                    Dosages and   Tolerance, Use, Limitations
                    Formulation(s)
                Pest list continued from previous page.
ITBCCRA
/28045AA
Western yellow-
 striped armyworm

Rangeland (grass)
ITBNAJA
Range caterpillar
              240 ppm (forage and hay)
              No preharvest interval through 0.5
              pound per acre of ultra low volume
              liquid formulations in oil for foli-
              ar application.  Do not make more
              than 3 applications during growing
              season.
              No preharvest interval through 1
              pound per acre of dilute spray or
              ultra low volume formulations for
              foliar application.  For dilute
              sprays do not make more than 3 ap-
              plications per cutting or per grow-
              ing season if grass is not cut for
              hay.  For ultra low volume sprays do
              not make more than 1 application per
              cutting or per growing season if
              grass is not cut for hay.
              Applications may be made without re-
              moval of livestock.

0.25-0.5 Ib/A Ultra low volume foliar application.
(1.5 Ib/gal   Apply by aircraft.  Apply to active-
                                     RTU)
                                  ly feeding and mobile larvae in the
                                  third through fifth instars.   A sec-
                                  ond application may be made if need-
                                  ed.
                                    Also refer  to Pasture  (grass)  for additional pest
                                    and use information.
            Issued:   3-22-82
                           111-057901-23
                                                  49

-------
/28076AA
ITBCCFA
IQAMARA
IMOAAAA
ITBCCBA
ITBCCFA
IVAHAAA
ITABACA

ITBCCXA
/28023BA
ITBCCFA
ITBCCNA
IVAHAAA

ITBCABA
ITABACA

ITBCCRA
ITBCCFA
IOAAAEA

IXBJAHA
                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
Site and Pest           Dosages and   Tolerance, Use, Limitations
                        Formulation(s)

  Safflower                           0.1 ppm (seed)
                                      Apply up to the onset of bloom
                                      through 1.5 pounds per acre for fo-
                                      liar application or soil application
                                      (band or broadcast).  Do not make
                                      more than 2 applications during the
                                      growing season.
                                      Do not apply after onset of bloom.

    Armyworm            1.25-1.5 Ib/A Foliar application.  May be applied
    Lygus bugs          (3-8% D)      by aircraft.  Apply approximately 14
    Thrips                or          days prior to bloom and repeat at
    Variegated cutworm  1-1.5 Ib/A    onset of bloom.
                        (50-80% SC/S)
    Armyworm
    Crickets
    Saltmarsh cater-
     pillar
    Surface feeding
     cutworms
1.5 Ib/A
(5% D)
(4-5% G)
[Bait]
  Soybeans (seed crop)
    Armyworm            1-1.5 Ib/A
    Beet annyworm       (5% D)
    Crickets (including (4-5% G)
     mole crickets)     [Bait]
    Cutworms (climbing
     and surface feed-
     ing including
     black cutworm,
     granulate cut-
     worm, variegated
     cutworm, western
     bean cutworm)
    Saltmarsh cater-
     pillar
    Western yellow-
     striped armyworm

    Armyworm            1.25-1.75
    Dipterous leaf-      Ib/A
     miner              (5% D)
    Imported cabbage-     or
Soil application (band).  Apply over
the row and around base of plants.

Broadcast soil application.  May be
applied by aircraft.  For fields
with previous infestations or sus-
pected infestations of surface feed-
ing cutworms, apply prior to or just
after planting.

N.F.
Do not pasture or harvest treated
crop for feed, food, forage, or oil.

Soil application (band).  Apply over
the row and around base of plants.

Broadcast soil application.  May be
applied by aircraft.  For fields
with previous infestations or sus-
pected infestations of cutworms,
apply prior to or just after plant-
ing.
              Foliar application.
              by aircraft.
                     May be applied
            Issued:   3-22-82
                               111-057901-24
                                                  50

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                                  EPA Index to Pesticide Chemicals

                        DIMETHYL (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
IQAMARA
IQAQAAA
ITBCCBA
/28020AA
ITBMBUA
ITBCCNA
ITBMBWA
lOAAAEA

ITABACA

ITBCCBA

ITBMBUA
ITBCCNA
ITABACA
ITBMBWA
ITBCCBA
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
Soybeans (seed crop) (continued)

   worm               1-1.5 Ib/A
  Lygus bugs          (6 Ib/gal
  Stink bugs           SC/L)
  Variegated cutworm  (50-80% SC/S)

Spinach (greenhouse research crops)
                      See Bean, Lima (greenhouse research crops)
                      cluster.
Sugar Beets
  Alfalfa webworm
  Beet armyworm
  Beet webworm
  Dipterous leaf-
   miners
  Saltmarsh cater-
   pillar
  Variegated cutworm

  Alfalfa webworm
  Beet armyworm
  Saltmarsh cater-
   pillar
  Beet webworm
  Variegated cutworm
1-1.5 Ib/A
(3-8% D)
1-1.5 Ib/A
(4-6 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)

0.5-1 Ib/A
(4-6 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)
              0.1 ppm
              12 ppm (tops)
              14 day preharvest interval through
              1.5 pounds per acre for foliar ap-
              plication or soil application (band
              or broadcast) if tops are not to be
              fed to livestock.
              28 day preharvest interval through
              1.5 pounds per acre for foliar ap-
              plication or soil application (band
              or broadcast) if tops are to be fed
              to livestock.
Foliar application.
by aircraft.
May be applied
            Issued:   3-22-82
                            111-057901-25
                                                  51

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
IOAAAEA
ITBCCFA
IVAHAAA
ITBCABA
INBUAAA
ITABACA
ITBCCXA
/26003AA
ITBCBNA
ITBRAKA
ITBCCFA
ITBCCNA
IVAHAAA

ITBCABA
                        Dosages and   Tolerance, Use, Limitations
                        Formulatlon(s)
              Sugar Beets (continued)
    Dipterous leaf-
     miners
    Armyworm
    Crickets
    Cutworms (climbing
     and surface feed-
     ing including
     black cutworm,
     granulate cut-
    Darkling beetles
    Saltmarsh cater-
     pillar

    Surface feeding
     cutworms
  Tobacco
    Tobacco budworm
    Tobacco hornworm
1 Ib/A
(4-6 Ib/gal
 SC/L)
(40.5%
 SC/L)***
(50-80% SC/S)

1-1.5 Ib/A
(5% D)
(3-5% G)
[Bait]
1 Ib/A
(5% P/T)
[Bait]
Soil application (band).  Apply over
the row and around base of plants.

Broadcast soil application.  May be
applied by aircraft.  For fields
with previous infestations or sus-
pected infestations of cutworms,
apply prior to or just after plant-
ing.
Broadcast soil application.
              N.F.
              3 day preharvest interval through 1
              pound per acre of spray formulations
              or 1.5 pounds per acre of dust and
              granular formulations for foliar ap-
              plication.
              Do not apply bait formulations after
              plants are 2 feet tall.

1-1.5 Ib/A    Foliar application.  For budworm,
(5-8% D)      apply directly into bud.  Repeat as
  or          needed.
0.4-0.6 Ib/A
(4% G)
  or
1 Ib/A
(50-80% SC/S)
    Armyworm
    Beet armyworm
    Crickets (including
     mole crickets)
    Cutworms (climbing
     and surface feed-
     ing including
     black cutworm,

Issued:  3-22-82
1 Ib/A
(5% D)
(4-5% G)
[Bait]
Soil application (band).  Apply over
the row and around base of plants.

Broadcast soil application.  May be
applied by aircraft.  For fields
with previous infestations or sus-
pected infestations of cutworms, ap-
ply prior to or just after planting.
                                           111-057901-26
                                                 52

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                                  EPA  Index to Pesticide Chemicals

                        DIMETHYL (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
ITABACA

ITBCCRA


/26003DA

INBPALC
/11005AA
ITBCCFA
IOAAAEA

IOABADA

ITSRAJA

IOAAAEA

IOABADA

IIBRAJA
            Site and Pest
              Tobacco (continued)
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
  Pest list continued from previous page.

   granulate cut-
   worm, variegated
   cutworm, western
   bean cutworm)
  Saltmarsh cater-
   pillar
  Western yellow-
   striped armyworm
Tobacco (to be transplanted)

  Green June beetle   0.5 lb/
   (larvae)            100 gal/
                       100 sq.yd
                      (50-80% SC/S)

Tomato
  Armyworm
  Dipterous leaf-
   miners
  Serpentine leaf-
   miner complex
  Tomato hornworm

  Dipterous leaf-
   miners
  Serpentine leaf-
   miner complex
  Tomato hornworm
1-1.25 Ib/A
(3-8% D)
1 Ib/A
(6 Ib/gal
 SC/L)
(50-80% SC/S)
              Soil application.  Apply to uprooted
              areas of plant beds.
              0.1 ppm
              No preharvest interval through 1.25
              pounds per acre of dust formulations
              for foliar application to tomatoes
              to be cooked (canning) before mar-
              keting .
              21 day preharvest interval through 1
              pound per acre of spray formulations
              or 1.25 pounds per acre of dust for-
              mulations for foliar application.
              28 day preharvest interval through 1
              pound per acre of bait formulations
              for soil application (band or broad-
              cast).
              Do not graze fields treated with
              bait formulations.
Foliar application.
by aircraft.
May be applied
            Issued:   3-22-82
                             111-057901-27
                                                  53

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-1-HYDROXYETHYL)PHOSPHONAIE
ITBCCFA
ITBCCNA
IVAHAAA

ITBCABA
INBUAAA
ITABACA

ITBCCRA
            Site and Pest
              Tomato (continued)
                    Dosages and   Tolerance, Use, Limitations
                    Formulation(s)
Armyworm            1 Ib/A
Beet armyworm       (5% D)
Crickets (including (3-5Z G)
 mole crickets)     [Bait]
Cutworms (climbing
 and surface feed-
 Ing including
 black cutworm,
 granulate cut-
 granulated cut-
 worm, variegated
 cutworm, western
 bean cutworm)
Darkling beetles
Saltmarsh cater-
 pillar
Western yellow-
 striped armyworm
Soil application (band).  Apply over
the row and around base of plants.

Broadcast soil application.  May be
applied by aircraft.  For fields
with previous Infestations or sus-
pected infestations of cutworms,
apply prior to or just after plant-
ing.
                                    See Field Crops cluster.

                                    See Barley cluster.
            Issued:   3-22-82
                           111-057901-28
                                                  54

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                                  EPA Index  to  Pesticide Chemicals

                        DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
            LIVESTOCK AND POULTRY
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
            General Warnings and Limitations:  Do not treat lactating dairy cattle,
            animals less than 3 months old (unless otherwise specified), convalescent,
            or stressed livestock.  Do not apply in conjunction with oral drenches, or
            other internal medications, or with other organic phosphates, or materials
            having cholinesterase inhibiting activity.
/50004IA
/53001IA
(Dairy Animals)

Dairy Cattle (non-lactating)
IOAWABA
IMAAADA
  Cattle grubs (in-
   cluding common
   cattle grub and
   northern cattle
   grub)
  (Lice)
0.5 fl.oz 8%
 RTU/100 Ib
 body wt.
(8% RTU)
0.1 ppm (meat, fat and meat bypro-
ducts of cattle)
0.01 ppm (milk)
7 day prefreshening interval through
0.5 fluid ounce of 8 percent ready-
to-use formulation per 100 pound
body weight for pour on application.
Do not apply more than 4 fluid oun-
ces of 8 percent ready-to-use formu-
lation per animal.  If freshening
occurs within 7 days after treat-
ment, do not use milk for human con-
sumption for the balance of the 7
day interval.
21 day preslaughter interval through
0.5 fluid ounce of 8 percent ready-
to-use formulation per 100 pound
body weight for pour on application.

Animal treatment.  Pour on applica-
tion.  Apply a single treatment
along the backline.  Proper timing
of treatment is important.  Treat
cattle as soon as possible after fly
activity ceases.  Host parasite re-
actions sometimes occur when cattle
are treated while the common cattle
grub is in the gullet, or while the
northern cattle grub is in the area
of the spinal cord.  Consult your
veterinarian, extension livestock
specialist, or extension entomolo-
gist regarding timing of treatment.
If it is impossible to determine the
origin of the cattle, and thus the
exact stage of the grubs is unknown,
feed only a maintenance ration of
low energy feed during the treatment
period.  This lessens the likelihood
of severe bloat which may occur in
            Issued:   3-22-82
                             111-057901-29
                                                  55

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
                      Dosages and   Tolerance, Use, T.I mi tat Ions
                      Formulatlon(s)
              Dairy Cattle (non-lactatlng) (continued)
/530011A
              (Livestock Intended for Slaughter)
Beef Cattle
IOAWABA
  Cattle grubs (In-
   cluding common
   cattle grub and
   northern cattle
   grub)
8 lb/100 gal
(80% SC/S)
                                                  cattle on full feed when the common
                                                  cattle grub Is killed while In the
                                                  gullet.  Do not treat animals for 10
                                                  days before or after shipping or
                                                  weaning,  or after exposure to conta-
                                                  gious or Infectious diseases.
0.1 ppm (meat, fat, and meat bypro-
ducts of cattle)
0.01 ppm (milk)
14 day preslaughter Interval through
8 pounds of soluble concentrate/
solid formulation per 100 gallons of
water for animal spray application.
Do not apply more than 4 fluid oun-
ces of 8 percent ready to use formu-
lation per animal.

Animal spray treatment.  Apply a
single treatment with high pressure
(250 to 350 pounds per square Inch)
to thoroughly wet the skin.  Operate
box-type spray chutes at maximum
pressure.  Do not spray in a con-
fined, nonventilated area.  Proper
timing of treatment is important.
Treat cattle as soon as possible
after fly activity ceases.  Host
parasite reactions sometimes occur
when cattle are treated while the
common cattle grub is in the gullet,
or while the northern cattle grub is
in the area of the spinal cord.
Consult your veterinarian, extension
livestock specialist, or extension
entomologist regarding timing of
treatment.   If it is impossible to
determine the origin of the cattle,
and thus the exact stage of the
grubs is unknown, feed only a main-
tenance ration of low energy feed
            Issued:   3-22-82
                             111-057901-30
                                                  56

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                                  EPA  Index  to  Pesticide  Chemicals

                        DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
              Beef Cattle (continued)
                                                  during the treatment period.  This
                                                  lessens the likelihood of severe
                                                  bloat which may occur in cattle on
                                                  full feed when the common cattle
                                                  grub is killed while in the gullet.
                                                  Do not treat animals for 10 days be-
                                                  fore or after shipping or weaning,
                                                  or after exposure to contagious or
                                                  infectious diseases.
IQAUADA
IMAAADA
  Horn fly
  Lice
8 lb/100 gal
(80% SC/S)
       spray treatment.  Apply to
the point of run off.  Repeat as
needed.
                                    Refer to (Dairy Animal's), Dairy Cattle (non-lac-
                                    tating) for additional information.
              (Livestock Not Intended for Slaughter)
/56005IA
Horses
IOASAAA
  Horse bots
              0.1 ppm (meat, fat, and meat bypro-
              ducts of horses)
              Do not treat horses to be slaugh-
              tered for food.  Do not treat sick
              or debilitated horses, mares in the
              last month of pregnancy, or colts
              under 4 months of age.  Do not
              administer in conjunction with or
              for 10 to 14 days (depending upon
              the product) before or after treat-
              ment with other organic phosphates
              or chollnesterase inhibitors.
              Symptoms of overdosage are ataxia
              and colic.

9 g/5-10      Animal treatment.  Administer by
 fl.oz/500 Ib stomach tube or drench.  The suspen-
 body wt.     sion may be stored for 24 hours.
(37.8% WP/D)  Prepare doses individually.  Repeat
              at 30 day intervals as needed.
              Formulated with thiabendazole.
                                    9 g/500 Ib
                                     body wt.
                                    (37.8% WP/D)
                                    (37.8-90%
                                     P/T)
                                    Animal treatment.  Administer dry or
                                    dissolved in water.  Mix with the
                                    amount of feed to be consumed at 1
                                    feeding.  Withdrawal of feed 12 to
                                    18 hours prior to treatment will
                                    assure complete ingestlon.   Repeat
                                    at 90 to 120 day intervals.   Do not
            Issued:  3-22-82
                             111-057901-31
                                                  57

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
              Horses (continued)
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
                                                  repeat treatment more frequently
                                                  than every 30 days.  Do not admin-
                                                  ister intravenous anesthetics,
                                                  especially muscle relaxant, for a
                                                  period of 14 days after treatment.
                                                  May be formulated with thiabenda-
                                                  zole.
            AGRICULTURAL PREMISES AND EQUIPMENT

            General Warnings and Limitations;   Good sanitation is a necessary part of
            any house fly control program.  Direct application to walls, floors, or
            other surfaces previously treated  with lime, whitewash, or other alkaline
            materials may be ineffective.  On  limed floors, where floors are lacking,
            or where there is not enough clean floor space available, treat and dis-
            tribute bait on sacking, boards, or cardboard strips.  Dry and liquid
            baits may be applied daily,  if needed, until flies are controlled.  Do not
            contaminate milk or milk handling  equipment.  Do not contaminate feed,
            drinking water, litter,  and  feed troughs.   Do not treat portions of build-
            ings where animals can lick  the treated surface.

              (Dairy Barns Including Milk Rooms.  Equipment and Barnyards)
/50000JA
/60004JA
/53000JA
/52000JA

IVAAABA
IOAUAFA
Dairy Barns
Milking Rooms
  Cockroaches
  House fly
              0.1 ppm (meat, fat, and meat bypro-
              ducts of cattle)
              0.01 ppm (milk)
0.032-0.04 oz Premise treatment.  Dry bait.  Scat-
 /1,000 sq.ft ter directly on areas where pests
(0.4-12 G)    breed or congregate.   Scatter light-
              ly on floors, alleyways, window
              sills, and other clean horizontal
              surfaces.  For faster results, apply
              to a moistened surface.
                                    0.16 oz/gal
                                    (1%  G)
                                    Premise treatment.   Liquid bait.
                                    Mix with 1 pound of sugar or 2 cups
                                    of corn syrup.   Sprinkle on floors,
                                    alleyways, window sills, and other
                                    areas where pests congregate.
            Issued:   3-22-82
                             111-057901-32
                                                  58

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                                  EPA Index  to  Pesticide  Chemicals
                        DIMETHYL (2,2,2-TBULCHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
              Dairy Barns cluster (continued)

                                    Syrup bait
                                    (1% G)
/50000KA
/60004KA
/53000KA
/52000KA

IVAAABA
IQAUAFA
Dairy Barns (manure treatment)
Milking Rooms (manure treatment)
  Cockroaches
  House fly
0.04 oz/
 1,000 sq.ft
(1% G)

0.16 oz/gal
(1% G)
/890030A
IVAAABA
IOAUAFA
Garbage Dumps (dairy barn and
 milking room premises)
  Cockroaches
  House fly
0.04 oz/
 1,000 sq.ft
(1% G)

0.16 oz/gal
(1% G)
              Premise treatment.  Apply in suffi-
              cient water to make a syrup.  Brush
              onto vertical surfaces, ceiling
              cracks, and rafters where pests con-
              gregate.  For flies in areas not
              clean enough, apply to sacks,
              boards, or strips of cardboard and
              place them inside or outside build-
              ings where pests congregate.

              0.1 ppm (meat, fat, and meat bypro-
              ducts of cattle)
              0.01 ppm (milk)
Manure treatment.  Dry bait.  Scat-
ter directly onto manure where pests
breed or congregate.

Manure spot treatment.  Liquid bait.
Mix with 1 pound of sugar or 2 cups
of corn syrup.  Sprinkle directly
onto manure where pests breed or
congregate.

0.1 ppm (meat, fat, and meat bypro-
ducts of cattle)
0.01 ppm (milk)

Dry bait.  Scatter directly onto
garbage dumps where pests breed or
congregate.

Liquid bait.  Mix with 1 pound of
sugar or 2 cups of corn syrup.
Sprinkle directly on garbage dumps
where pests breed or congregate.
            Issued:  3-22-82
                             111-057901-33
                                                  59

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                                  EPA Index to  Pesticide  Chemicals

                        DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
              (Animal Buildings, Equipment and Outdoor Areas For Other Than Dairy,
              Poultry and Pets)
/53000JA
IOAUAFA
Animal Buildings (including
 barns, shelters, and stables)
              0.1 ppm (meat, fat, and meat bypro-
              ducts of cattle, goats, horses, and
              sheep)
  House fly
12 impr waxed Bait application.  Dip tray in water
 tray         before attaching tray under garbage
(12 Impr)     can lids or hanging on walls out-
              doors where pests accumulate.  Keep
              waxed tray moist.

4 lb/40 gal   Premise residual spray treatment.
 [2 gal/1,000 Remove animals before spraying.  Ap-
 sq.ft]       ply in and around buildings and
(80Z SC/S)    stock pens.  Apply to ceilings,
              floors, walls, and other areas where
              flies breed and congregate.  Repeat
              as needed, but not more frequently
              than 4 to 14 day intervals.  For
              longer residual activity, add 1
              pound of sugar per gallon of spray.

Refer to (Dairy Barns Including Milk Rooms, Equip-
ment and Barnyards), Dairy Barns cluster for addi-
tional information.
/53000KA
Animal Buildings (manure treatment)
                                    Refer to (Dairy Barns Including Milk Rooms,  Equip-
                                    ment and Barnyards),  Dairy Barns (manure treat-
                                    ment) cluster.
/890030A
IOAUAFA
Garbage Dumps (animal building
 premises)
              0.1 ppm (meat, fat, and meat bypro-
              ducts of cattle, goats, horses, and
              sheep)
  House fly
1% impr waxed Bait application.  Dip tray in water
 tray         before attaching tray under garbage
(12 Impr)     can lids or hanging on walls out-
              doors where pests accumulate.  Keep
              waxed tray moist.
            Issued:   3-22-82
                             III-057901-34
                                                  60

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                                  EPA Index to Pesticide Chemicals

                        DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONAIE

            Site and Pest           Dosages and   Tolerance, Use, Limitations
                                    Formulatlon(s)

              Garbage Dumps (animal building premises) (continued)

                                    4 lb/40 gal   Premise residual spray treatment.
                                     [2 gal/1,000 Apply to refuse, garbage dumps, and
                                     sq.ft]        other areas where flies breed and
                                    (80% SC/S)    congregate.  Repeat as needed, but
                                                  not more frequently than 7 to 14 day
                                                  intervals.  For longer residual ac-
                                                  tivity,  add 1 pound of sugar per
                                                  gallon of spray.

                                    Refer to (Dairy Barns Including Milk Rooms, Equip-
                                    ment and Barnyards), Garbage Dumps (dairy barn and
                                    milking room premises) for additional information.

              (Feed Lots, Holding Pens and Corrals)

/52000JA      Feed Lots                           0.1 ppm (meat, fat, and meat bypro-
/52000JA      Pens                                ducts of cattle, goats, horses, and
                                                  sheep)

                                    Refer to (Dairy Barns Including Milk Rooms, Equip-
                                    ment and Barnyards), Dairy Barns cluster.

/52000KA      Feed Lots (manure treatment)        0.1 ppm (meat, fat, and meat bypro-
/52000KA      Pens (manure treatment)             ducts of cattle, goats, horses, and
                                                  sheep)

                                    Refer to (Dairy Barns Including Milk Rooms, Equip-
                                    ment and Barnyards), Dairy Barns (manure treat-
                                    ment) cluster.

/890030A      Garbage Dumps (feed lots and pen    0.1 ppm (meat, fat, and meat bypro-
               premises)                          ducts of cattle, goats, horses, and
                                                  sheep)

                                    Refer to (Dairy Barns Including Milk Rooms, Equip-
                                    ment and Barnyards), Garbage Dumps (dairy barn and
                                    milking room premises) for additional information.


            HUMAN. PETS AND OTHER ANIMALS

            General Warnings and Limitations;  Good sanitation is a necessary part of
            any house fly control program.  Do not treat portions of buildings or
            areas where animals can lick the treated surface.  Apply baits in areas
            Inaccessible to children and animals.  Do not contaminate feed or drinking
            water.
            Issued:  3-22-82               111-057901-35
                                                   61

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                                  EPA Index to Pesticide Chemicals

                        DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
/54000JA
/54003JA

IVAAABA
IOAUAFA
            Site and Pest
Animal Hospitals
  Cockroaches
  House fly
                      Dosages and   Tolerance, Use,  Limitations
                      Formulation(s)
0.04 oz/
 1,000 sq.ft
(1% G)
                                    0.16 oz/gal
                                    (1% G)
                                    Syrup bait
                                    (1% G)
/54029IA
/65031MA
Bait Fish and Goldfish
IIEAABA
IIAAABA

IDCAABA
  Anchor worms
  Fishlice
   (argulus sp.)
  Gill flukes
A concentra-
 tion of 25
 ppm in the
 pond
(80% SC/S)
Premise treatment.  Dry bait.  Scat-
ter outside runways, on window
sills, on ledges, and other areas
where pests congregate.  For caged
units, apply along edges of dropping
area.  For faster results, apply to
a moistened surface.

Premise spot treatment.  Mix with 1
pound of sugar or 2 cups of corn
syrup.  Apply outside runways and
areas where pests congregate.

Premise spot treatment.  Apply in
sufficient water to make a syrup.
Brush onto vertical surfaces and
areas where pests congregate.

Consult your State Fish and Game
Agency before applying this product
to public waters.  Permits may be
required before treating such
waters.  Apply when the water tem-
perature at the 2 foot level is 85 F
(29.4 C).

Water treatment to control fish
parasites.  Mix in sufficient water
to permit even distribution over the
pond surface.  Apply uniformly to
the pond surface by sprinkler can,
low pressure sprayer, or by metering
into the wake of a power driven
boat.  Apply in a criss-cross pat-
tern covering the entire pond sur-
face.
For anchor worm and fishlice make 4
applications at 7 day intervals.
For gill flukes make 1 application.
            Issued:   3-22-82
                             111-057901-36
                                                   62

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                                  EPA Index  to Pesticide Chemicals

                        DIMETHYL  (2,2,2-mCHLORO-l-HYDROXYETHYL)PHOSPHONATE
/54002JA
/54003JA

IMNAAAA
            Site and Pest
Cat Quarters
Dog Quarters

  Fleas
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
/54003IA
Dogs
/54003JA

IQAUAFA
Dog Kennels

  House fly
/54002JA

IOAUAFA
Pet Kennels
  House fly
40 g/gal
 [1 gal/
 1,000 sq.ft]
(80% SC/S)
Use limited to professional pest
control operators.
Premise treatment.  Apply to yard
area and other areas frequented by
animals.  Remove animals before
treatment and let deposit dry before
allowing animals back into treated
area.  Repeat as needed.
                                                  This use only occurs on multiple
                                                  active ingredient labeling and has
                                                  not been included in this single
                                                  active ingredient entry.  Refer to
                                                  appropriate labeling for use infor-
                                                  mation and limitations.
40 g/8.75 Ib  Use limited to professional pest
 sugar        control operators.
 [4 this/     Premise treatment.  Dry bait.  Scat-
 1,000 sq.ft] ter on outside runways, on window
(80Z SC/S)    sills, on ledges, and other areas
              where pest congregate.  Repeat as
              needed.

40 g/gal      Use limited to professional pest
 [5 gal/      control operators.
 1,000 sq.ft] Premise treatment.  For longer re-
(80% SC/S)    sidual control, mix with 1 pound of
              sugar or molasses per gallon of wa-
              ter.  Apply as a spray or brush onto
              areas where pest congregate.

Refer to Animal Hospitals for additional informa-
tion.
0.032 oz/
 1,000 sq.ft
(0.4% G)
Premise treatment.  Dry bait.  Scat-
ter on areas where pest congregates.
            Issued:  3-22-82
                             111-057901-37
                                                   63

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
            ORNAMENTALS
                      Dosages and   Tolerance. Use, Limitations
                      Formulation(s)
            General Warnings and Limitations;  Phytotoxlcity has occurred on certain
            varieties of carnation, hydrangeas, and zinnias.  When treating large
            plantings of these flovers for the first time, treat a few plants and ob-
            serve for 4 to 5 days before treating the entire planting.  Do not handle
            treated plants until spray deposit has dried.

              (Ornamental Plants (herbaceous, woody shrubs, trees and vines))
/31142AA

IOBJAEA
Narcissus
  Narcissus bulb fly
1 lb/100 gal/ Soil drench.  Direct stream at base
 1,000 ft row of plants at the beginning of adult
(6 Ib/gal     activity (early May to June).  Re-
 SC/L)        peat annually.
(50-80Z SC/S)
/32005AA
/35000AA
/630030A

ITAXAIB
Ornamental Evergreens
Ornamental Shade Trees
  Gypsy moth (eggs)
2 oz 40.5% -
 SC/L/gal
(40.5% SC/L)
Bark application.  Treat egg masses
on tree trunks and limbs, under
bark, on fences, and in wood piles
and rock walls.  Apply to the point
of run off, usually in April or
shortly before larval emergence.
Egg masses usually begin hatching in
mid-April, but can vary according to
location.  Consult your State Agri-
cultural Extension Service for prop-
er timing of application in your
area.
            Issued:   3-22-82
                             111-057901-38
                                                  64

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/3100QAA

/35000AA
/34000AA

ITBCCFA
ITBKABA
ITBCCZA
IQAAAEA

IQAMARA
IQAQAAA
IQAMATA
ITBCBNA
ITAAAMA
/31000AA
/31000DA
ITBCCFA
IVAHAAA
ITABACA
/35098AA

ITBGBLA

ITBMBCA
                      EPA Index  to Pesticide Chemicals

            DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

Site and Pest           Dosages and   Tolerance. Use, Limitations
                        Formulation(a)

  Ornamental Herbaceous Plants
   (including annuals)
  Ornamental Shade Trees
  Ornamental Woody Shrubs and Vines
    Annyworm
    Bagworm
    Climbing cutworms
    Dipterous leaf-
     miners
    Lygus bugs
    Stink bugs
    Tarnished plant bug
    Tobacco budworm
    Webworms
(5% D)
  or
0.167-0.25
 oz**/gal
  or
1-1.5 lb/
 100 gal
(4-6 Ib/gal
 SC/L)
(40.5Z
 SC/L)***
(50-fiOZ SC/S)
  Ornamental Herbaceous Plants (in-
   cluding aster, chrysanthemum,
   daisy, iris, and nursery stock)
Foliar application.  For dust formu-
lation, apply to both upper and low-
er surfaces of leaves.  For spray
formulations, apply until plants are
thoroughly wet.  Repeat as needed.
    Aimyworm
    Crickets
    Saltmarsh cater-
     pillar
1-1.5 Ib/A
(5% G)
Foliar application.
  Pine
    Nantucket pine tip  0.167 oz**/
     moth                gal
    Zimmerman pine moth   or
                        1 lb/100 gal
                        (4-6 Ib/gal
                         SC/L)
                        (40.52
                         SC/L)***
                        (50-80% SC/S)
              Foliar application.  Apply until
              plants are thoroughly wet.  Repeat
              as needed.
            Issued:  3-22-82
                               111-057901-39
                                                  65

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONAIE
            Site and Pest
                      Dosages and   Tolerance. Use, Limitations
                      Formulation( s)
              (Lawns and Turf (including ground covers))
/330100A
/330080A
Lawns
Ornamental Turf
ISASAAA
ITBCCFA
IQALAEA
IVAHAAA
ITBCABA
ITABACA

ITBMABA
  Ants
  Armyworm
  Chinch bug
  Crickets
  Cutworms (including
   surface feeding
   cutworms)
  Saltmarsh cater-
   pillar
  Sod webworm s
0.125-0.625
 lb/5,000
 sq.ft
(5-6.2Z G)
  or
0.625-0.9375
 lb/5,000
 sq.ft
 [up to
 75-150 gal/
 5,000 sq.ft]
(4-6 Ib/gal
 SC/L)
(50Z SC/S)
  or
0.375-0.9375
 lb/5,000
 sq.ft
 [up to
 75-150 gal/
 5,000 sq.ft]
(80Z SC/S)
Do not graze or use clippings from
treated areas for feed or forage.
Keep children and pets off treated
areas until spray has dried for
spray formulations.  After granular
application, water the lawn using
75 to 150 gallons of water per
5,000 square feet.

Application to established lawns and
turf.  For sod webworms, mow lawn
and rake dead grass from damaged
areas.  Water lawn and allow grass
to dry before spraying.  Do not wat-
er again for at least 3 days.  Apply
up to 3 applications at 21 to 28 day
intervals.  Up to 3 applications may
be needed for maximum control.  In
most areas, the first application
should be made in May or June.  Con-
sult your State Agricultural Exten-
sion Service for more specific in-
formation.
ISASAVA
  Texas harvester ant 0.67-1 cup
                       5Z G/mound
                      (5Z G)
              Broadcast application over mound
              surface.   Inspect treated mound
              regularly and repeat applications
              as needed.
            Issued:   3-22-82
                             111-057901-40
                                                   66

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

            Site and Pest           Dosages and   Tolerance, Use,  Limitations
                                    Formulatlon(s)
              Lawns cluster (continued)
INBPAAA
  White grubs (in-
   cluding Asiatic
   garden beetle,
   European chafer,
   Japanese beetle,
   May beetle, North-
   ern masked chafer,
   and Oriental
   beetle)
0.9375 lb/
 5,000 sq.ft
(5-6.2Z G)
  or
0.9375 lb/
 5,000 sq.ft
 [up to
 75-150 gal/
 5,000 sq.ft]
(4 Ib/gal
 SC/L)
(50-802 SC/S)
Application to established lawns and
turf.  Apply when grubs are young
and actively feeding near the soil
surface usually during July and
August.  Do not attempt to control
grubs in turf areas that have over
0.5 to 0.75 inch thatch build up
since heavy thatch (0.75 to 2 in-
ches) will prevent the insecticide
from penetrating down to the area
where pests are feeding.  Remove
thatch before treating.  A second
application may be needed for large
sized larvae.  Thoroughly irrigate
turf immediately after application.
Irrigation may be postponed, based
on actual count and species of grub
present.  Refer to 80 percent sol-
uble concentrate/solid formulation
labels for specific watering sched-
ule.
              (Ornamental and Forest Greenhouse Plants)
/32008CA
Weed Hosts of Plant Pathogens
 (greenhouse research crops)
                                                  This use only occurs  on Special
                                                  Local Need (24(C))  labeling and has
                                                  not been included in  this  entry.
                                                  Refer to appropriate  labeling for
                                                  use information and limitations.
            Issued:  3-22-82
                             111-057901-41
                                                  67

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
                        Dosages and   Tolerance, Use, Limitations
                        Formulation(s)
            FOREST,  CHAPARRAL,  NONAGRICULTURAL AND WASTELANDS
/30000AA
  Forest Trees
ITAUAGA
ITAXAIC
    Forest tent cater-  0.75 Ib/A
     pillars            (4 Ib/gal
                         SC/L)
    Gypsy moth (larvae) 1 Ib/A
                        (4 Ib/gal
                         SC/L)

                        1 Ib/A
                        (1.5 Ib/gal
                         RTU)
ITBUASA
    Spruce budworm
0.5-1 Ib/A
(4 Ib/gal
 SC/L)
Do not apply directly to water or
wetlands except under the forest
canopy.  Consult State Agricultural
Extension Service for proper timing
of application in the area infested.
Application of undiluted trichorphon
can cause spotting of automobile
paint surfaces if exposure is per-
mitted.  If accidental exposure does
occur, the car should be washed im-
mediately.

Use limited to AL and LA.
Ultra low volume foliar application.
Apply undiluted by aircraft.  Repeat
as needed.

Ultra low volume foliar application.
Apply undiluted by aircraft.  Repeat
as needed.

Ultra low volume foliar application.
Apply by aircraft.  Schedule appli-
cations in accordance with the rec-
ommendation of local gypsy moth con-
trol authorities.  Repeat as needed.

Use limited to ME and NH.
Ultra low volume foliar application.
Apply undiluted by aircraft when ap-
proximately 50 percent of the larvae
are in the fourth instar.  Repeat as
needed.
/65031MA
NQNCROP AQUATIC AREAS

  Ponds
              Consult your State Fish and Game
              Agency before applying this product
              to public waters.   Permits may be
              required before treating such
              waters.

Refer to HUMAN, PETS AND OTHER ANIMALS, Bait Fish
and Goldfish, for additional information.
            Issued:   3-22-82
                               111-057901-42
                                                  68

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                                 EPA Index to Pesticide Chemicals
                       DIMETHYL  (2,2,2-XRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
                      Dosages and   Tolerance. Use, Limitations
                      Formulation(s)
            DOMESTIC DWELLINGS. MEDICAL FACILITIES AND SCHOOLS

            General Warnings and Limitations;   Good sanitation is a necessary part of
            any house fly control program.  Do not contaminate food, drinking water,
            or utensils.  Do not allow children or pets in treated areas until sprayed
            surfaces are dry.  Apply baits in areas Inaccessible to children and pets.
            Dry and liquid baits may be applied daily, if needed, until flies are con-
            trolled.
/630010A
Domestic Dwellings (Indoor)
IQAFACA
  Bed bug
40 g/gal
(80% SC/S)
IVAAABA
IVAHAAA
IMPBACA
  Cockroaches
  Crickets
  Silverfish
Bait
(0.92-1% G)
                                    40 g/19 Ib
                                     sugar
                                      or
                                    0.46% dry
                                     bait
                                    (80% SC/S)

                                    40 g/gal/
                                     750 sq.ft
                                    (80% SC/S)
The 80 percent soluble concentrate/
solid formulation is limited to pro-
fessional pest control operators.

Indoor treatment.  Apply as a coarse
spray or brush onto baseboards,
cracks, and crevices.  Treat beds
including a light application to
tufts and seams of mattresses.   Do
not soak mattresses.  Treated mat-
tresses should be aired for at least
8 hours or until dry.  Do not treat
infant bedding or cribs.

Indoor treatment.  Dry bait.  Place
a small quantity on pieces of paper,
cardboard, or in shallow jar lids.
Place in protected areas such as in
closets, under sinks or refrigera-
tors, and where dying insects cannot
fall into food, utensils, or drink-
ing water.  Any bait visible after
application should be carefully
brushed into cracks and crevices or
removed.  Wet the bait slightly for
increased killing efficiency.

Indoor treatment.  Dry bait.  Apply
to areas where pests congregate.
                                    Indoor spot treatment.   For residual
                                    control,  apply ai a coarse spray or
                                    brush onto baseboards,  cracks,  crev-
                                    ices, and other areas where pests
                                    hide or congregate.  Repeat as  need-
                                    ed.
            Issued:  3-22-82
                             111-057901-43
                                                  69

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

            Site and Pest           Dosages and   Tolerance.  Use.  Limitations
                                    Formulatlon(s)

              Domestic Dwellings  (Indoor) (continued)
IMNAAAA
ILAAACA
  Fleas
  Ticks
40 g/gal/
 750 sq.ft
(80Z SC/S)
Indoor treatment.  Apply to infested
areas including rugs, draperies,
furniture, baseboards, cracks, crev-
ices, and all places where pests are
found.  Before spraying fabric, test
spray on small hidden area to insure
that the spray will not stain.  In
animal sleeping and holding areas,
remove old bedding and spray floor
thoroughly.  Replace with fresh bed-
ding after spray dries.  Do not
spray pets directly.  Allow sprayed
areas to thoroughly dry before con-
tact.  Repeat as needed.
/630030A
Domestic Dwellings (Outdoor)
ISASAAA
IVAHAAA
IMDAAAA
  Ants
  Crickets
  Earwigs
IOAUAFA
  House fly
              The 80 percent soluble concentrate/
              solid formulation is limited to pro-
              fessional pest control operators.

0.4-0.8 oz/   Outdoor treatment.  Dry bait.  Apply
 1,000 sq.ft  around perimeter of building.
(5Z G)

0.32 oz/      Outdoor treatment.  Dry bait.  Apply
 1,000 sq.ft  lightly on ground, grass, near foun-
(1% G)        datlon of house, along sidewalk and
              driveway, around porches, doors and
              other entrances to the house.  Apply
              in late afternoon and repeat at 14
              day intervals as needed.

40 g/8.75 Ib  Outdoor treatment.  Dry bait.  Apply
 sugar        to areas where pests congregate.
 [4 this/     Repeat as needed.
 1,000 sq.ft]
(80Z SC/S)

40 g/gal      Outdoor treatment.  Apply as a
 [2.5-5 gal/  coarse spray or brush onto selected
 1,000 sq.ft] surfaces where pest congregates.
(80% SC/S)    Mix spray with 1 pound of sugar per
              gallon for longer residual control.
              On manure piles, apply the high
              rate.  Repeat at 7 to 14 day inter-
              vals as needed.
            Issued:   3-22-82
                             111-057901-44
                                                  70

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                                  EPA Index to Pesticide Chemicals

                        DIMETHYL (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
                      Dosages and   Tolerance, Use, T.imi tations
                      Formulation(s)
              Domestic Dwellings (Outdoor) (continued)
ISASAVA
  Texas harvester ant 0.67-1 cup
                       5% 6/mound
                      (5% G)
/890030A

IVAAABA
IOAUAFA
Garbage Dumps

  Cockroaches
  House fly
IOAUAFA
  House fly
/880030A

IVAAABA
IOAUAFA
Latrines (Outdoor)

  Cockroaches
  House fly
              Broadcast application over mound
              surface.  Inspect treated mound
              regularly and repeat applicaions as
              needed.
                                    Refer to ORNAMENTALS, (Ornamental Plants (herba-
                                    ceous, woody shrubs, trees and vines)), Ornamental
                                    Evergreen cluster for additional information.

                                    Refer to URBAN AND RURAL INDOOR/OUTDOOR AREAS
                                    (PUBLIC HEALTH), Recreational Areas (including
                                    Picnic Areas) for additional information.
0.04 oz/
 1,000 sq.ft
(1Z G)
Dry bait.  Scatter directly on gar-
bage dumps where pests breed or con-
gregate.
0.16 oz/gal   Liquid bait.  Mix with 1 pound of
(1% G)        sugar or 2 cups of corn syrup.
              Sprinkle directly on garbage dumps
              where pests breed or congregate.

1% impr waxed Bait application.  Dip tray in water
 tray         before attaching tray under garbage
(1% Impr)     can lids or hanging on walls out-
              doors where pests accumulate.. Keep
              waxed tray moist.

40 g/gal      Use limited to professional pest
 [5 gal/      control operators.
 1,000 sq.ft] Apply as a coarse spray.  Mix spray
(80% SC/S)    with 1 pound of sugar per gallon for
              longer residual control.  Repeat at
              7 to 14 day intervals as needed.
0.04 oz/
 1,000 sq.ft
(1% G)
                                    0.16 oz/gal
                                    (1% G)
Dry bait.  Scatter lightly where
pests breed or congregate.  For
faster results, apply to a mois-
tened surface.

Liquid bait.  Spot treatment.  Mix
with 1 pound of sugar or 2 cups of
corn syrup.  Sprinkle where pests
congregate.
            Issued:  3-22-82
                             111-057901-45
                                                  71

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                                 EPA Index to Pesticide Chemicals

                       DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE
            Site and Pest
                      Dosages and   Tolerance. Use. Limitations
                      Formulation(s)
            URBAN AND RURAL INDOOR/OUTDOOR AREAS (PUBLIC HEALTH)
/670020A
/630030A

IVAAABA
IQAUAFA
Recreational Areas (including
 Picnic Areas)
  Cockroaches
  House fly
0.04 oz/
 1,000 sq.ft
(1% G)
                                    0.16 oz/gal
                                    (1% G)
                                    Syrup bait
                                    (1% G)
Dry bait.  Scatter lightly where
pests breed or congregate.  For
faster results, apply to a moistened
surface.

Liquid bait.  Mix with 1 pound of
sugar or 2 cups of corn syrup.
Sprinkle where pests congregate.

Syrup bait.  Spot treatment.  Mix in
enough water to make a syrup.  Brush
on vertical surfaces and other areas
where pests congregate.
IQAUAFA
  House fly
12 impr waxed Bait application.  Dip tray in water
                                     tray
                                    (1% Impr)
/890030A
IVAAABA
IQAUAFA
Garbage Dumps (Recreational Area
 Premises)
  Cockroaches
  House fly
0.04 oz/
 1,000 sq.ft
(1% G)

0.16 oz/gal
(1% G)
                                    before attaching tray under garbage
                                    can lids or hanging on walls out-
                                    doors where pests accumulate.  Keep
                                    waxed tray moist.  Apply to areas
                                    inaccessible to children and pets.
Dry bait.  Scatter directly on gar-
bage dumps where pests breed or con-
gregate.

Liquid bait.  Mix with 1 pound of
sugar or 2 cups of corn syrup.
Sprinkle directly on garbage dumps
where pests breed or congregate.
IQAUAFA
  House fly
1% impr waxed Bait application.  Dip tray in water
 tray         before attaching tray under garbage
(1% Impr)     can lids or hanging on walls out-
              doors where pests accumulate.  Keep
              waxed tray moist.  Apply to areas
              inaccessible to children and pets.
            Issued:   3-22-82
                             111-057901-46
                                                   72

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                                 EPA Index to Pesticide Chemicals

                        DIMETHYL  (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

            Site and Pest           Dosages and   Tolerance. Use. Limitations
                                    Formulation(s)

            COMMERCIAL ESTABLISHMENTS

            General Warnings and Limitations;  Good sanitation is a necessary part of
            any house fly control program.  Baits may be used in edible product areas.
            Do not use other formulations in edible product areas of food processing
            plants, restaurants,  or other areas where food is commercially prepared or
            processed.  Do not use in serving areas while food is exposed.  Apply
            baits in areas inaccessible to children and animals.

              (Commercial Establishments (edible product areas))

/71009JB      Poultry Packing Plants
/71008JB      Red Meat Packing Plants             Use limited to federally inspected
                                                  plants.   Use only when the facility
                                                  is not in operation and food is not
                                                  exposed.  Use only in bait boxes
                                                  where bait in each box can be ac-
                                                  counted for.  Remove and account for
                                                  ail bait boxes prior to resuming
                                                  food processing.

IVAAABA         Cockroaches         0.04 oz/      Indoor treatment.  Dry bait.
IQAUAFA         House fly            1,000 sq.ft
                                    (1* G)

                                    0.16 oz/gal   Indoor treatment.  Liquid bait.  Mix
                                    (1% G)        with 1 pound of sugar or 2 cups of
                                                  corn syrup.

                                    Syrup bait    Indoor treatment.  Syrup bait.  Mix
                                    (1% G)        in enough water to make a syrup.

              (Commercial Establishments (areas other than edible product))

              General Warnings and Limitations;   Do not treat cannery waste which may
              be fed to livestock.   Do not contaminate feed, food, water, or food pro-
              cessing equipment.

/77000JC      Commercial, Institutional and
               Industrial Areas (Inedible Areas)  The 80 percent soluble concentrate/
/72000JC      Eating Establishments (Inedible     solid formulation is limited to pro-
               Areas)fessional pest control operators.
/71000JC      Food Processing. Handling and
               Storage Plants/Areas (Inedible
               Areas)

IS/.SAAA         Ants                0.4-0.8 oz/   Outdoor treatment.  Dry bait.  Apply
IVAHAAA         Crickets             1,000 sq.ft  around perimeter of building.
                                    (5% G)


            Issued:  3-22-82               111-057901-47

-------
                                 EPA Index to Pesticide Chemicals
                        DIMETHYL  (2,2,2-TRICHLORO-l^IYDROXYETH YL)PHOSPHONATE
            Site and Pest
                      Dosages and   Tolerance, Use, Limitations
                      Formulation(s)
              Commercial, Institutional and Industrial Areas (Inedible Areas)
               (continued)
IVAAABA
  Cockroaches
IQAUAFA
  House fly
Bait
(1% G)
Indoor treatment.  Dry bait.  Place
a small quantity on pieces  of paper,
cardboard, or in shallow jar lids  in
locations Inaccessible to children
and animals.  Place where dying in-
sects cannot fall into food, uten-
sils, or drinking water.  Wet the
bait slightly for increased killing
efficiency.

Indoor or outdoor treatment.  Apply
as a coarse spray or brush  onto se-
lected interior and exterior sur-
faces of buildings where  pest con-
gregates.  Apply only when  animals
and humans are absent.  Do  not allow
reentry until treated surfaces are
dry.  Mix spray with 1 pound of su-
gar per gallon for longer residual
control.  Repeat at 7 to  14 day in-
tervals as needed.
                                    40 g/8.75 Ib  Indoor or outdoor treatment.   Apply
                                     sugar        where pest congregates.   Repeat as
                                     [4 this/     needed.
                                     1,000 sq.ft]
                                    (80% SC/S)
40 g/gal
 [1.33 gal/
 1,000 sq.ftj
(80Z SC/S)
ISASAVA
                      0.04 ozl
                       1,000 sq.ft
                      (1% G)

  Texas harvester ant 0.67-1 cup
                       5% G/mound
                      (5% G)
/890030A

IVAAABA
IOAUAFA
Garbage Dumps

  Cockroaches
  House fly
0.04 ozl
 1,000 sq.ft
(1% G)
              Outdoor treatment.  Dry bait.  Scat-
              ter on ground where pest congre-
              gates.

              Broadcast application over mound
              surface.  Inspect treated mound
              regularly and repeat applicaions as
              needed.
Dry bait.  Scatter directly on gar-
bage dumps where pests breed or con-
gregate.
            Issued:   3-22-82
                             111-057901-48
                                                  74

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                                  EPA Index to Pesticide Chemicals

                        DIMETHYL (2,2,2-IRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

            Site and Pest           Dosages and   Tolerance. Use, Limitations
                                    Formulation(s)

              Garbage Dumps (continued)

                                    40 g/gal      Outdoor treatment.  Apply to garbage
                                     [5 gal/      piles.  Mix with 1 pound of sugar
                                     1,000 sq.ft] per gallon for longer residual con-
                                    (80Z SC/S)    trol.  Repeat at 7 to 14 day inter-
                                                  vals as needed.


            AERIAL. MOTHPROOFING AND TANK MIX APPLICATIONS

9001500       Aerial Application
AAAAAAA
                —                  Refer to
                                    AGRICULTURAL CROPS
                                                  All sites except Field Crops, Truck
                                                  Crops, Tobacco (to be transplanted)
                                    FOREST. CHAPARRAL. NONAGRICULTURAL AND WASTELANDS
                                                  Forest Trees
            Issued:  3-22-82               III-057901-49
                                                   75

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                      EPA Index to  Pesticide  Chemicals

            DIMETHYL (2,2,2-IRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

Listing of Registered Pesticide Products by Formulation

902 technical chemical
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    011556-00006

971 technical chemical
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    011678-00003   013801-00015   040831-00108

982 technical chemical
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    002749-00181   003125-00009   011556-00030

80% formulation intermediate
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    002749-00103   003125-00066   003125-00129   007173-00104
    011678-00010   040831-00107

82% formulation intermediate
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    011556-00055

3% dust
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    001202-00269

5% dust
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    000635-00395   000769-00396   001202-00268   002342-00913
    002749-00331   003125-00064   010226-00036   040831-00102
    044317-00026

8Z dust
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    040831-00104

0.4% granular
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    002724-00225

0.92% granular
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    009172-00001

1% granular
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (037901)
    000239-00778   000270-00057   000327-00095   000869-00146
    001386-00281   001990-00491   002217-00557   003125-00007
    003125-00151   006762-00052   008590-00170   042057-00077
Issued:  3-22-82               111-057901-50
                                      76

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                      EPA Index  to  Pesticide  Chemicals

           DIMETHYL (2,2,2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

Listing of Registered Pesticide Products by Formulation (continued)

3% granular
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    010226-00029

3.5% granular
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    037686-00059

4% granular
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    002393-00437   009779-00187   037686-00058

5% granular
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    000829-00203   002269-00154   002935-00401   003125-00076
    003125-00217   005905-00229   006735-00193   007001-00113
    008612-00081   037686-00049

6.2% granular
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    002169-00211

5% pelleted/tableted
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    006973-00006

37.8% pelleted/tableted
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    000618-00085

90Z pelleted/tableted
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    000270-00060   000602-00214

37.8% wettable powder/dust
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901) plus
   thiabendazole (060101)
    000618-00086

1% impregnated materials
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    001663-00014

4 Ib/gal soluble concentrate/liquid
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    003125-00143   003125-00210   006735-00206   006735-00208
    040831-00111   042057-00097

6 Ib/gal soluble concentrate/liquid
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (05790])
    040831-00106

Issued:  3-22-82               111-057901-51
                                       77

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9999999
                      EPA Index to  Pesticide Chemicals

            DIMETHYL (2,2, 2-TRICHLORO-l-HYDROXYETHYL)PHOSPHONATE

Listing of Registered Pesticide Products by Formulation (continued)

40.5% soluble concentrate/liquid
  dimethyl (2,2, 2-trichloro-l-hydroxyethyl) phosphonate (057901)
    002749-00138   008730-00030   045128-00002

50% soluble concentrate/solid
  dimethyl (2, 2, 2-trichloro-l-hydroxyethyl) phosphonate (057901)
    003125-00049   003125-00089

80% soluble concentrate/solid
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901)
    000769-00506   001021-00336   001023-00051   002749-00107
    002749-00116   003125-00118   003125-00184   003125-00227
    003770-00287   011556-00031   011556-00039   011678-00011
    040831-00103

1.5 Ib/gal liquid ready-to-use
  dimethyl (2,2,2-trichloro-l-hydroxyethyl) phosphonate (057901) plus
   petroleum distillate (063503)
    003125-00278

8% liquid ready-to-use
  dimethyl (2,2, 2-trichloro-l-hydroxyethyl) phosphonate (057901)
    002393-00389   002724-00218   002749-00147   003770-00288
    011556-00032

State Label Registrations

AZ Reg. No.
    010163-06400   037832-08360
CA Reg. No.
    001202-05069
    006023-03051
    007001-07754
    009319-04536
                               003125-07849
                               006973-03552
                               006434-04719
                               009319-04550
003125-07850
006973-03553
008434-04721
011093-07253
005967-05190
006973-03554
009319-04535
FL Reg. No.
    002342-06966
    009859-04432

GA Reg. No.
    001812-03875

NY Reg. No.
    003125-07832

PA Reg. No.
    003125-07831

TX Reg. No.
    003125-07830

Issued:  3-22-82
                               002342-06968
                               014775-08743
                               038655-10422
003125-07838
035222-07160
009859-03942
                                           111-057901-52
                                      78

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II.    REQUIREMENT FOR SUBMISSION OF GENERIC DATA

    A.  This portion of the guidance document is a Notice
        issued under the authority of FIFRA Section 3(c)(2)(B)
        and describes, in table format, the data required
        for maintaining the registrability of each product.
        Additionally, a bibliography (Appendix II-l) is
        included that identifies that data considered as
        part of the data base supporting this standard.  EPA
        has determined that additional generic data described
        in this Notice must be submitted to EPA for evaluation
        in order to maintain in effect the registration(s)
        of your product(s) identified as an attachment to
        the cover letter accompanying this guidance document.
        As required by FIFRA Section 3(c)(2)(B), you are
        required to take appropriate steps to comply with
        this Notice.

        EPA may suspend the registration of each of those products
        unless, within the specified time, you have informed F,PA
        how you will satisfy the requirements of this Notice.
        Any such suspension will remain in effect until you have
        complied with the terms of this Notice.

    B.  What Generic Data I/ Must Be Submitted.  You may ascertain
        which generic data you must submit by consulting Table A
        at the end of this chapter.  That table shows all the
        generic data needed to evaluate the continued registrability
        of all products, and the dates by which the data must be
        submitted.  The required data must be submitted and any
        necessary studies must be conducted in accordance with
        EPA-approved protocols, the Pesticide Registration
        Guidelines 2_/', or data collected under the approved
        protocols of the Organization for Economic Cooperation
        and Development (OECD).  If you wish not to develop data
        which are necessary to support the registration or
        reregistration of certain uses appearing in your labeling,
        you may delete those uses at the time you submit your
        revised labeling.

        Also for certain kinds of testing (generally ecological
        effects), EPA requires the test substance to be a "typical
        formulation," and in those cases EPA needs data of that
    I/ Generic data pertain to the properties or effects of a
particular ingredient, and thus are relevant to an evaluation of
the risks of all products containing that ingredient (or all such
products having a certain use pattern), regardless of a.iy such
product's unique composition or use.  Procuct-specific data relate
only to the properties or effects of a prodi.ct with a particular
composition (or a group of products with closely similar composition)

    2/ The Pesticide Registration Guidelines were reproposed on
November 24, 1982 in 47 Federal Register 53192.
                                  79

-------
        type for each major formulation category (e.g., emulsifiahle
        concentrates, wettable powders, granulars,  etc.)  These
        are classified as generic data and when needed are
        specified in Table A.  EPA may possess data on certain
        "typical formulations" but not others.  Note;  The "typical
        formulation" data should not be confused with product-
        specific data (Table B) which are required on each
        formulation.  Product-specific data are further explained
        in Chapter IV of this document.

    C.  Options Available for Complying With Requirements
        to Submit Data

        Within 90 days of your receipt of this Notice you must
    submit to EPA a completed copy of the form entitled "FIFRA
    Section 3(c)(2)(B) Summary Sheet" [EPA Form 8580-1, Appendix
    11-2}  for each of your products.  On that form you must
    state which of the following methods you will use to comply
    with the requirements of this Notice:

    1.  (a) Notify EPA that you will submit the data, and

        (b) either submit the existing data you believe
            will satisfy the requirement, or state that
            you will generate the data by conducting
            testing.  If the test procedures you will
            use deviate from (or are not specified in)
            the Registration Guidelines or protocols
            contained in the Reports of Expert Groups
            to the Chemicals Group, Organization for
            Economic Cooperation and Development (OECD)
            Chemicals Testing Programme, you must enclose
            the protocols you will use.

    2.  Notify EPA that you have entered into an agreement
        with one or more other registrants to jointly
        develop (or share in the cost of developing) the
        data.  If you elect this option, you must notify EPA
        which registrants) are parties to the agreement.

    3.  File with EPA a completed "Certification of Attempt to
        Enter Into an Agreement With Other Registrants for
        Development of Data" (EPA Form 8580-6, Appendix II-3)_V

    4.  Request that EPA amend your registration by deleting the
        uses for which the data are needed.  (This option is not
        available to applicants for new products.)
     V FIFRA Section 3(c)(2)(B) authorizes joint development of
data by two or more registrants, and provides a mechanism by
which parties can obtain an arbitrator's decision if they agree
to jointly develop data but fail to agree on all the terms of
the agreement.  The statute does not compel any registrant to
agree to develop data jointly.
(Footnote continued at bottom of next page)
                                  80

-------
    5.  Request voluntary cancellation of the registrationfs)
        of your products for which the data are needed.  (This
        option is not available to applicants for new products.)

    D.  Procedures for Requesting Changes in Testing Methodology
        and Extensions of Time

        EPA recognizes that you may disagree with our conclusions
        regarding the appropriate ways to develop the required
        data or how quickly the data must be submitted.  If the
        test procedures you plan to use deviate from (or are not
        specified in) the registration guidelines or protocols
        contained in the reports of the Expert Groups to the
        Chemical Groups, Organization for Economic Cooperation
        and Development (OECD) Chemicals Testing Programme, you
        must submit the protocol for Agency review prior to the
        initiation of the test.

        If you think that you will need more time to generate the
        required data than is allowed by EPA's schedule, you may
        submit a request for an extension of time.  The extension
        request must be submitted in writing to the Product
        Manager.  The extension request should state the reasons
        why you conclude that an extension is appropriate.   While
        EPA considers your request, you must strive to meet the
        deadline for submitting the required data.
(Footnote continued from previous page)
     In EPA's opinion, joint data development by all registrants
who are subject to the requirements to submit a pertinent item
of data or a cost-sharing agreement among all such registrants
is clearly in the public interest.  Duplication of testing could
increase costs, tie up testing facilities, and subject an unneces-
sarily large number of animals to testing.
      As noted earlier, EPA has discretion not to suspend the
registration of a product when a registrant fails to submit data
required under FIFRA Section 3(c)(2)(B).  EPA has concluded that
it is appropriate to exercise its discretion not to suspend in
ways which will discourage duplicative testing.  Accordingly, if
(1) a registrant has informed us of his intent to develop and
submit data required by this Notice; and (2) a second regis-
trant informs EPA that it has made a bona fide offer to the
first registrant to share in the expenses of the testing [on
terms to be agreed upon or determined by arbitration under FIFRA
Section 3 ( c) ( 2 ) (B) ( iii ) ] ; and (3) tl
-------
                                                     TABLE A
                                    GENERIC DATA REQUIREMENTS FDR TRICHLORFON
§158.120 - PRODUCT CHEMISTRY
Guideline Citation and Test
Name of Test Substance V
PRODUCT IDENTITY:
61-1 - Identity of Ingredients
61—2 SLciLwiKitinL o£ CurtiposiLioti
61-3 - Discussion of Formation of
Ingredients
Analysis and Certification of Product
Ingredients
62 1 Preliminary Analysis
62-2 - Certification of Limits
62-3 - Analytical Methods for
Enforcement of Limits
Physical and Chemical Characteristics

63-3 - Physical State
63-4 - Odor
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
Guidelines Are Data Footnote
Status Required 2/ Number
Yes No
R ffl
R/Y /
/A/
R XV
CR A7
R A7
R A7
R A/
R/Y/
/A/
R /V
n
n
n
n
n
n
n
n
n
                                                                82

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                                                     TABLE A
                                    GENERIC DATA REQUIREMENTS FOR TRICHLORFON
§158.120 - PRODUCT CHEMISTRY (Con't)
Guideline Citation and
Name of Test
Test
Substance I/
Guidelines Are Data Footnote
Status Required 2/ Number
Yes No
Physical and Chemical Characteristics
(Continued)
DO D rieiting foint
DJ o aoiiing roint
63-7 - Density, Bulk Density, or
Specific Gravity
63-8 - Solubility 1
63-9 - Vapor Pressure
DJ lu Dissociation constant
63-11 - Octanol/water partition
coefficient
63-12 - pH
63-13 - Stability
63-20 - Corrosion Characteristics
Other Requirements:
64-1 - Submittal of samples
TGAI
TGAI
TGAI
DGAI or PAI
PAI
PAI
PAI
TGAI
TGAI
TGAI
Choice
DATA REQUIREMENT FOOTNOTES:
V Composition: TGAI=Technical Grade of the Active
2/ Data must be submitted no later than December,
R
R
R
R
R
R
R
R
R
R
CR
Ingredient;
1984.
A/
A/
A7
A/
A7
A/
/v
A7
n

PAI=Pure
.—j
A7 3/
n
n
n
n
n
n
n
n
A7

Active Ingredient
3/ Not required because the technical material is a solid at room temperature.

-------
                                                          TABLE A
                                             GENERIC DATA REQUIREMENTS FOR TRICHLORFON
      Data Requirements
 Composition
      Does EPA Have Data
      To Satisfy This
V    Requirement? (Yes,
      No or Partially)
Bibliographic
  Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
158.125 Residue Chemistry

  171-4 - Nature of Residue (Metabolism)

        - Plants



        - Livestock
     PAIRA
PAIRA and plant
 metabolites
        Partial
        Partial
00005296
00005300
00091787

00005297
     Yes3/
     Yes4/
  171-4 - Residues Analytical Method

        - Plant residues
        - Animal residues
  171-4 - Storage Stability Data
TGAI and meta-
 bolites
TGAI and meta-
 bolites
 PAI
        Yes
        Yes
        Yes
GS0104038
GS0104005
GS0104007
GS0104041
GS0104060
GS0104001
GS0104002

GS0104006
GS0104056
GS0104057

GS0104008
GS0104061
     No
     No
     No
                                                             84

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                                                           TABLE A
                                             GENERIC DATA REQUIREMENTS FOR TRICHLORFON
      Data Requirements
Composition
      Does EPA Have Data
      To Satisfy This
V    Requirement? (Yes,
      No or Partially)
Bibliographic
  Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
158.125 Residue Chemistry
        (continued)

  171-4 - Magnitude of the Residue-
           Residue Studies for Each
           Food UseV

        - Root and Tuber Vegetables Group

          0 Rutabagas                            TEP

          0 Beets                                TEP

          0 Radishes                             TEP.

          0 Carrots                              TEP

          0 Sugar Beets                          TEP

          0 Turnips                              TEP

        - Leaves of Root and Tuber Vegetables Group

          0 Beet Tops                            TEP

          0 Sugar Beet Tops                      TEP

        - Bulb Vegetables Group

          0 Garlic                               TEP

          0 Onions                               TEP

        - Leafy Vegetables (Except Brassica Vegetables)  Group

          0 Spinach                              TEP

          0 Lettuce                              TEP

          0 Celery                               TEP
                      No

                      Yes

                      No

                      Partial

                      No

                      No



                      Yes

                      No



                      No

                      No



                      No

                      Partial

                      No
                           GS0104009
                           GS0104010
                           GS0104009
                           GS0104011
                       Yes6/


                       No

                       Yes6/

                       Yes?/

                       Yes8/
                                                  Yes6/

                                                  Yes6/



                                                  Yes6/
                                                  Yes6/
                                                              85

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                                                    TABLE A
                                       GENERIC DATA REQUIREMENTS FOR TRICHLORFON
Data Requirements
Composition
      Does EPA Have Data
      To Satisfy This
V    Requirement? (Yes,
      No or Partially)
                                  Bibliographic
                                    Citation
                                                                                                    Must Additional
                                                                                                    Data Be Submitted
                                                                                                    Under  FIFRA Section
                                                                                                    3(c)(2)(B)?2/
TEP

TEP

TEP

TEP

TEP

TEP
158.125 Residue Chemistry
        (continued)

  171-4 - Magnitude of the Residue-
           Residue Studies (continued)

        - Brassica Leafy Vegetables Group

          0 Brussels Sprouts

          0 Broccoli

          0 Cabbage

          0 Kale

          0 Cauliflower

          0 Collards

        - Legume Vegetables (Succulent or Dried)  Group

          0 Cowpeas (succulent and dried)        TEP

          0 Dried Beans                          TEP

          0 Lima Beans                           TEP


          0 Snap Beans                           TEP

        - Foliage of Legume Vegetables Group

          0 Bean Vines                           TEP

          0 Cowpea Vines                         TEP

          0 Lima Bean Vines and Hay              TEP
           No

           No

           No

           No

           Partial

           No



           Partial

           Partial

           Partial


           Partial



           No

           Partial

           Partial
                                                                             GS0104012
                                                                            GS0104013

                                                                            GS0104003

                                                                            GS0104014
                                                                            GS0104062

                                                                            GS0104015
                                      GS0104013

                                      GS0104014
                                      GS0104063
                                                                                                   YesV
                                                             YesW
                                                                                                   Yes20/

-------
                                                          TABLE A
                                             GENERIC DATA REQUIREMENTS FOR TRICHLORTON
      Data Requirements
Composition
      Does EPA Have Data
      To Satisfy This
V    Requirement? (Yes,
      No or Partially)
Bibliographic
  Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
158.125 Residue Chemistry
        (continued)

  171-4 - Magnitude of the Residue-
           Residue Studies (continued)

        - Fruiting Vegetables (Except Cucurbits)  Groups

          0 Peppers                              TEP

          0 Tomatoes                             TEP

        - Fruiting Vegetables Curcubits Group

          0 Pumpkins                             TEP

          0 Watermelon                           TEP

        - Citrus Fruits Groups

          0 Citrus Fruits                        TEP

        - Small Fruits and Berries Group

          0 Blueberries                          TEP

          0 Strawberries                         TEP

        - Cereal Grains Group

          0 Barley                             •  TEP

          0 Corn                                 TEP
            Oats

            Wheat
    TEP

    TEP
           Partial

           Partial



           Partial

           No



           Partial



           Yes

           No



           Partial

           Yes


           Partial

           Partial
                                      GS0104016

                                      GS0104017



                                      GS0104018
                                      GS0104064
                                      GS0104067
GS0104019

GS0104043
GS0104020

GS0104021

GS0104022
                       Yes£f/
                       No

                       Yes£/
                                                             No
     Yes27/

     Yes28/

-------
                                                     TABLE A
                                       GENERIC DATA REQUIREMENTS FDR TRICHLORF3N
Data Requirements
                                             Composition
      Does EPA Have Data
      To Satisfy This
V    Requirement? (Yes,
      No or Partially)
Bibliographic
  Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/
158.125 Residue Chemistry
        (continued)

  171-4 - Magnitude of the Residue-
           Residue Studies (continued)

        - Forage, Fodder, and Straw of Cereal Grains Group

          0 Barley Forage and Straw              TEP
      Corn Forage and Fodder
      Oat Forage and Straw
                                                 TEP
                                                 TEP
                                                             Partial
           Yes
           Partial
                                                             Partial
          0 Wheat Forage and Straw               TEP

          Grass Forage, Fodder, and Hay Group

          0 Pasture Grasses (forage and hay)     TEP               Partial

          0 Rangeland Grasses (Forage and Hay)   TEP               Partial

          Non-Grass Animal Feeds (Forage, Fodder, Straw,  and Hay)  Group

          0 Alfalfa Forage and Hay               TEP               Partial
      Birdsfoot Trefoil Hay
      Clover Forage and Hay
                                                 TEP
                                                 TEP
           Partial


           Partial
GS0104044
GS0104023

GS0104045
GS0104024

GS0104046
GS0104025

GS0104047
GS0104026
                                                                             GS0104048

                                                                             GS0104049
GS0104050
GS0104027

GS0104068
GS0104051

GS0104052
GS0104028
GS0104053
GS0104054
     Yes£9_/


     No


     Yes30/


     Yes31/



     Yes32/

     Yes33/



     Yes^4/


     Yes35/
                                                         88

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                                               TABLE A
                                 GENERIC DATA REQUIREMENTS FOR TRICHLORFON
Data Requirements
158.125 Residue Chemistry
(continued)
171-4 - Magnitude of the Residue-
Residue Studies (continued)
- Miscellaneous Crops
0 Artichokes
0 Bananas
0 Cottonseed
0 Flax
0 Peanuts
0 Saf flower Seed
0 Tobacco
- Food Producing Animals
0 Cattle (Fat, meat and
meat byproducts)




0 Goats, Horses, and Sheep

0 Milk


V
Composition





TEP
TEP
TEP
TEP
TEP
TEP
TEP

EP, TGAI or
Plant Metabolites




EP, TGAI or
Plant Metabolites
EP, TGAI or
Plant Metabolites

Does EPA Have Data
To Satisfy This
Requ irement ? ( Yes ,
No or Partially)





No
Yes
No
Partial
Yes
Partial
No

Partial





Yes

Partial


Bibliographic
Citation





-
GS0104040
-
GS0104030
GS0104058
GS0104031
-

GS0104032
GS0104033
GS0104034
GS0104035
GS0104036
GS0104065
GS0104066

GS0104037
GS0104038
GS0104055
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/





Yes37/
NO
Yes^V
OQ /
^Jf^fiJ _7 /
No
YesfV
Yesf/

Yes42/





No

YesfV


Poultry and Eggs
EP, TGAI or
Plant Metabolites
Partial
GS0104004
Yes44/
                                                   PQ

-------
                                  TABLE A
                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry

_!/  Composition:  TGAI = Technical grade of the active ingredient; PAIRA =
    Pure active ingredient, radiolabelled; TEP = Typical end-use product;
    EP = End-use product.

2/  Data must be submitted no later than  June .  1 987	.
3/  The following additional data are required:

    o  Studies demonstrating the degree of absorption of trichlorfon by
       both leaves and roots of representative crops as well as the subsequent
       translocation and metabolism of trichlorfon and/or its metabolites.
       [14c]Trichlorfon must be used for these studies.  An attempt must
       be made to identify all metabolites including volatile, toxic
       compounds (which may include DDVP).  If additional metabolites of
       concern are indicated, additional methodology and residues studies
       for the r.a.c.s may be required.

_4/  The following studies are required to adequately define the animal
    metabolism of trichlorfon:

    o  Metabolism studies utilizing both poultry and ruminants.  Animals
       must be orally dosed with [^-^C]trichlorfon and the identity and
       distribution of residues in tissues, milk, and eggs, where appropriate,
       must be detemined.  If, however, the ruminant study indicates that
       no additional metabolites of concern exist then the poultry study
       may be waived.

    o  In addition,  a metabolism study with C1^]trichlorfon should be
       performed reflecting the use of the high-pressure dermal spray
       application of the 80% SC/S at 8 Ib. a.i./A gallon.  Meat and milk
       samples must be analyzed for the identity and distribution of
       possible residues of concern.

    o  If additional residues of concern besides the parent compound
       trichlorfon per se are found, additional methodology and residue
       data for meat and milk may have to be submitted.

5/  Dust formulations are manufactured in low volumes and are rarely applied
    to crops.  Therefore, data are not required for dust formulations unless
    there is an indication that dust is frequently used on a given crop.

6/  There are currently no federally registered products for this use.

7/  The available data do not support the established tolerance for carrots.
    Residue data were submitted only for SC/S applications.  These residue
    values were below the tolerance; however, geographic representation was
    inadequate.  The following additional data are required:
                                       90

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                                   TABLE A
                  Generic Data Requirements for Trichlorfon

 §158.125  Residue Chemistry
           (continued)

     o  Foliar treatments (aerial and ground) at geographically representative
        field sites with either one of the SC/L or one of the SC/S formulations
        at 1.5 Ib ai/A and subsequent residue analyses which reflect the
        maximum registered use pattern.  Field site data must include arid
        regions in California; alternatively, a label restriction against
        usage on irrigated carrots may be proposed.

     o  The registrant must submit information specifying the method of
        application used in the tests reviewed in this section of the
        trichlorfon Standard.

 8/  No valid data are available to support the sugar beet tolerance; all
     residue data submitted were generated with an invalid cholinesterase
     inhibition technique.  The following data are required:

     o  Foliar treatments with one of the SC/L or SC/S formulations at 1.5
        Ib ai/A and subsequent residue analyses on roots which reflect the
        maximum current use pattern.

     o  Residue data for processed sugar beet products (molasses, dehydrated
        pulp, and refined sugar) if residues are detected in the raw agricul-
        tural commodity.

 9/  Based on the available data, a tolerance of 0.1 ppm (negligible) should
     be established for trichlorfon residues in or on table beet tops.  No
     Codex MRL or Canadian or Mexican tolerance exists for trichlorfon resi-
     dues in or on beet tops.  The existing label directions are considered
     to be adequate except that the restriction against using beet tops as
     food must be deleted.

10/  The available residue data are not sufficient to support the established
     tolerance for lettuce.  Only the 50% SC/S formulation was tested? resi-
     dues were below the tolerance except in the case of the trial conducted
     in CA, the principal growing region.  Several pertinent aspects were un-
     specified:  whether or not data for head lettuce represent heads with or
     without wrapper leaves, the application method (aerial or ground), and
     whether or not field sites in CA and AZ were irrigated.  Additional data
     are required which reflect:

     o  Field trials in CA or AZ (irrigated and non-irrigated plots of head
        and leaf lettuce) and in CO and NY with one of the SC/S formulations
        at 1 Ib ai/A.  Soil and foliar applications must be made at three or
        more weekly intervals with ground and aerial equipment.  Sampling
        (with and without wrapper leaves) should reflect the maximum current
        use pattern.
                                          91

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                                  TABLE A
                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry
          (continued)

     o  Head and leaf lettuce field trials in CA or AZ (irrigated and non-
        irrigated plots) and CD and NY with one of the G formulations at 1.5
        Ib ai/A.  Applications (over the row and around the plant base) must
        be made at three or more weekly intervals with ground and aerial
        equipment.  Sampling (with and without wrapper leaves) should reflect
        the current maximum application rate and use.

ll/  There are no valid data to support the established tolerance for
     residues resulting from the maximum registered rate for brussels
     sprouts because the analytical method used to detect trichlorfon
     residues is invalid.  The following residue data are required:

     o  Field trials from sites in CA, TX, and AZ using one of the SC/S
        formulations or the 6 Ib/gal SC/L formulation at 1 Ib ai/A.  Soil
        and foliar applications must be made at three or more weekly
        intervals with ground and aerial equipment.  Sampling should reflect
        the maximum current use pattern.

12/  There are no valid data to support the established tolerance for resi-
     dues resulting from the maximum registered rate for cabbage because the
     colorimetric method used detected the degradation products of trichlor-
     fon rather than the parent compound.   Further, the analytical method
     (a cholinesterase inhibition technique) used to detect trichlorfon
     residues is not valid.  The following data are required:

     o  Field trials from sites in FL, TX, NC,  NJ, and CA using the 6 Ib/gal
        SC/L or one of the SC/S formulations at 1 Ib ai/A,  and one of the G
        (bait) formulations at 1 Ib ai/A.   Soil (G only) and foliar
        applications must be made at three or more weekly intervals with
        ground and aerial equipment.  Sampling (with and without wrapper
        leaves) should reflect the maximum current use pattern.

13/  The available data do not support the established tolerance for residues
     in or on cauliflower resulting from the maximum registered rate.  Only
     the 5% D formulation was tested at a single Canadian site and the appli-
     cation method (ground or aerial) was unspecified.  Other data were
     obtained with an invalid analytical method (a cholinesterase inhibition
     technique) used to detect trichlorfon residues.  The following data
     are required:

     o  Field trials from sites in CA, AZ, NY,  and MI using one of the SC/S
        formulations or the 6 Ib/gal SC/L formulation at 1 Ib ai/A and one
        of the G (bait) formulations at 1  Ib ai/A.  Soil (G only) and foliar
        applications must be made at three or more weekly intervals with
        ground and aerial equipment.  Sampling should reflect the maximum
        current use pattern.
                                       92

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                                  TABLE A
                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry
          (continued)

14/  There are no valid data to support the established tolerance for
     trichlorfon residues in or on collards resulting from the maximum
     registered rate because the analytical method (a cholinesterase
     inhibition technique) used to detect trichlorfon residues is not valid.
     The following data are required.

     o  Field trials from two or more Gulf Coast localities using one of the
        SC/S formulations or the 6 Ib/gal SC/L formulation at 1 Ib ai/A and
        one of the G (bait) formulations at 1.5 Ib ai/A.  Soil and foliar
        applications must be made at three or more weekly intervals with
        ground and aerial equipment.  Sampling should reflect the maximum
        use pattern.

15/  The available data do not support the established tolerance for cowpeas;
     however, residue data submitted for the SC/S formulation were below
     the tolerance.  Only one dried bean sample was submitted.  The follow-
     ing additional data are required:

     o  Soil applications with one of the G formulations (bait) at 1 Ib
        ai/A and subsequent residue analyses on cowpeas, which reflect the
        maximum current use pattern.  Data on dried seed must also be
        provided.

16/  The available data do not support the established tolerance for residues
     of trichlorfon in or on dried beans.  However, residues in or on dried
     soybeans grown in north central and southern states and Ontario were
     <0.02 ppm >14 days after the last of four applications of the 80% SC/S
     or 4 Ib/gal SC/L formulations at <1.5 Ib ai/A; these data satisfy the
     dried bean data requirements for SC/S and SC/L applications at all
     geographic locations except CA, CO, and WA.  The following additional
     data are required:

     o  Foliar applications with one of the SC/S or SC/L formulations and
        soil applications with one of the G formulations (bait) at 1.5 Ib
        ai/A and subsequent residue analyses on dried beans which reflect
        the maximum current use pattern.  Full geographic representation is
        required for G applications; SC/S or SC/L field trial data ar
        eneeded only for CA, CO, and WA.

IT/  The available data do not support the established tolerance for lima
     beans; however, data submitted for SC/S and SC/L applications were
     below the tolerance.  The following additional data are required:

     o  Broadcast soil applications with one o^ the G formulations (bait)
        at 1.5 Ib ai/A and subsequent residue analyses on beans (shelled)
        and beans in pods at intervals which reflect the maximum current
        use pattern.
                                        93

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                                  TABLE A
                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry
          (continued)

18/  The available data do not support the established tolerance for snap
     beans.  Residue trials were conducted only with the SC/S formulation;
     the test submitted from Wisconsin contained residue-exceeding values.
     Also, geographic representation was inadequate.  The following additional
     data are required:

     o  Foliar applications with one of the SC/L fornulations and soil
        applications with one of the G formulations (bait) at 1.5 Ib ai/A
        and subsequent residue analyses on beans at intervals which reflect
        the maximum current use pattern.  Test locations must include FL
        and GA.

19/  There are no data to support the established tolerance for bean vines.
     The following data are required:

     o  Residue dissipation studies following foliar applications with one
        of the SC/L or SC/S formulations at 1.5 Ib ai/A; this is necessary
        to establish a pregrazing interval as well as to support the
        tolerance for bean vines.

     o  Foliar applications with one of the SC/L or SC/S formulations at 1.5
        Ib ai/A and subsequent residue analyses on succulent and dried
        vines (vine hay) harvested 14 days after the last treatment.

20/  The available data do not support the established tolerance for cowpea
     vines.  Residue data were subitted only for the SC/S formulation; these
     residue values were below the tolerance.  No data for residues in or
     on vine hay were submitted.  The following additional data are required:

     o  Residue dissipation studies following foliar applications with one
        of the SC/L formulations at 1.5 Ib ai/A;  and soil application with one
        of the G formulations (bait) at 1 Ib ai/A; this is necessary to estab-
        lish a pregrazing interval for cowpea vines.

     o  Foliar applications with one of the SC/L or SC/S formulations at 1.5
        Ib ai/A and soil applications with one of the G formulations (bait) at
        1 Ib ai/a and subsequent residue analyses on succulent (SC/L and G
        formulations only) and dried vine (vine hay) harvested 14 days
        after the last treatment application.

21/  The available data do not support the established tolerance for lima bean
     vines and hay; however, data submitted for SC/S and SC/L applications were
     below the tolerance.

     There are no available data to support the established tolerance for lima
     bean vine hay.  The following additional data are required:
                                         94

-------
                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry
          (continued)

     o  Residue dissipation studies following two soil applications with one
        of the G formulations (bait) at 1.5 Ib ai/A; this is necessary to estab-
        lish a pregrazing interval for lima bean vines following G applications.

     o  Foliar applications with one of the SC/L or SC/S formulations and
        soil applications with one of the G formulations at 1.5 Ib ai/A and
        subsequent residue analyses on succulent (G formulations only) and
        dried vines (vine hay) harvested 3 (SC/S),  14 (SC/L), and 30 (G) days
        after the last treatment application.

22/  The available data do not support the established pepper tolerance follow-
     ing use of the registered formulations at their maximum application rates.
     Only the 50% SC/S and 5% D formulations were tested and the application
     method (aerial or ground) was unspecified for both formulations.  Additional
     data are required which reflect:

     o  Field trials from sites in FL, CA, NJ, NC and TX using one of the
        formulations at 1 Ib ai/A.  Soil (over the row and around plant bases)
        and foliar applications must be made at three or more weekly intervals
        with ground and aerial equipment.  Sampling should reflect the maximum
        current use pattern.

23/  The available data do not support the established tomato tolerance fol-
     lowing use of the registered formulations at their maximum application
     rates.  Residues were below the tolerance; however, only the 5% D and
     50% SC/S formulations were tested, the application method (aerial or
     ground) was unspecified, the prinicpal growing regions of the crop were
     not represented, and cooked samples were analyzed with an invalid method
     (see Report No. 2412 for description of the cholinesterase inhibition
     technique).  Additional data are required which reflect:

     o  Residue analysis of cooked tomatoes (washed and unwashed) following
        multiple (three or more) foliar or direct applicatons with one of
        the D formulations at 1.25 Ib ai/A.  The final treatment should be
        made on the day of sampling.

     o  Field trials from sites in FL and TX using an SC/S formulation at 1
        Ib ai/A.  Foliar applications must be made at three or more weekly
        intervals with ground and aerial equipment.  Sampling should reflect
        the maximum current use pattern.

     o  Field trials from sites in FL, SC, TX, AR,  CA and NJ using one of the
        G formulations at 1 Ib ai/A for multiple (three or more weekly inter-
        vals) soil and foliar applications, respectively,  with grouna and
        aerial equipment.  Sampling should reflect the maximum current use
        pattern.
                                        95

-------
                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry
          (continued)

     o  If residues are found in the tomato fruit, then a processing study
        is required to determine residues in pomace (wet and dry), puree,
        catsup and juice.

24/  The available data do not support the established tolerance for pumpkins;
     however, data are sufficient for SC/S applications.  The following addi-
     tional data are required:

     o  Single soil applications (made 14 days prior to harvest) of one of
        the G formulations at 1 Ib ai/A using aerial and ground equipment.

     Sufficient data are not available to assess the adequacy of the
     tolerance covering residues resulting from the maximum registered rate
     or the label directions.  No Canadian or Mexican tolerances exist for
     residues of trichlorfon in or on pumpkins.  The Codex MRL and U.S.
     tolerance are identical.

25/  The available data do not support the established tolerance for citrus
     fruit.   Since aerial applications can be made using spray volumes as low
     as 1 gallon/A, aerial ULV data are necessary reflecting that particular
     use.  The following additional data are required:

     o  Single aerial ULV applicatiosn followed by two ground applications
        of one of the SC/S formulations at 4 Ib ai/A and subsequent residue
        analyses on unwashed whole fruit at intervals which reflect the
        maximum current use pattern. .Data should be submitted for oranges,
        lemons, and grapefruit.

     o  Processing studies on oranges treated according to the application
        regime outlined above to determine residue in or on wet and dried
        pulp, oil, peel, juice, and molasses.

26/  The available data do not support the established tolerance for trichlorfon
     residues in or on barley grain which may result from use of the registered
     formulations in accordance with the label directions.  Only 50% SC/S formu-
     lation was tested; residues were below the tolerance, but only one application
     was made (up to three per season are permitted).   The method of application
     (ground or aerial) was unspecified.  Additional residue data are required
     which reflect the following:

     o  Multiple (> 3 weekly intervals) foliar aerial applications of one
        of the SC/L or one of the SC/S formulations at 1 Ib ai/A.

     o  If residues occur in grain,  then the fractionation study required for
        wheat will be sufficient to determine residues in barley germ and
        milled products.
                                        96

-------
                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry
          (continued)"

27/  The available data do not support the established tolerance for oat
     grain for the following reasons:  only a single application of the
     50% SC/L was made (up to three treatments per season are permitted);
     the application method (aerial or ground) was unspecified; and the
     tolerance-exceeding residues found in the CA test site cannot be con-
     sidered anomalous from the limited number of tests provided.  Additional
     data are required which reflect the following:

     o  Field trials conducted in NB and OH or NY which include multiple
        (three or more weekly intervals) foliar, aerial applications of one
        of the SC/L or SC/S formulations at 1 Ib ai/A.

     o  If residues occur in grain, then the fractionation study required
        for wheat will be sufficient to determine residues in milled
        products.

28/  The available data do not support the established tolerance for wheat
     grain for the following reasons:  only a single application of the
     50% SC/L was made (up to three treatments per season are permitted);
     the application method (aerial or ground) was unspecified; and the
     tests were not conducted in the principle wheat growing regions.
     Additional data are required which reflect the following:

     o  Field trials conducted in KS, TX or OK, IL or IN,  and MT which include
        multiple (three or more weekly intervals) foliar,  aerial applications
        of one of the SC/L or SC/S formulations at 1 Ib ai/A.

     o  If residues occur in grain, then a fractionation study is required
        to determine residues in milled products and by-products.

29/  The available data do not support the established tolerance for residues
     in or on barley straw which may result from use of the registered formu-
     lations at the maxittum application rate since only green samples were
     collected on the day of treatment.  The available data do support the
     established tolerance for barley forage.  The following additional
     residue data are required:

     o  Multiple (more than three weekly intervals) foliar, aerial treatments
        with one of the SC/L formulation or one of the SC/S formulations at
        1 Ib ai/A.  This is necessary to support the straw tolerance and to
        establish a prefeeding interval.

30/  The available residue data do not support the established tolerance for
     straw since only green samples were collected at zero and 3 days after
     treatment.  The available data do support the established tolerance
     for oat forage.  The following additional residue data are required:
                                        97

-------
                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry
          (continued)

     o  Multiple (three or more weekly intervals) foliar,  aerial treatments
        with one of the SC/k formulation or one of the SC/fe formulations at
        1 Ib aiA-  This is necessary to support the straw tolerance and to
        establish a prefeeding interval.

31/  The available residue data do not support the established tolerance for
     straw since only green samples were collected on the day of treatment.
     The available data do support the established tolerance for forage.
     Additional residue data are required which reflect the following:

     o  Multiple (more than three weekly intervals) foliar, aerial treatments
        with one of the SC/L formulations or one of the SC/fe formulations at
        1 Ib aiA-  This is necessary to support the forage and fodder toler-
        ances and to establish a prefeeding interval.

32 /  The available residue data do not support the established tolerances for
     trichlorfon residues in or on pasture grasses and hay following use of the
     registered formulations at their maximum registered rates.  The following
     additional data are required:

     o  Aerial and ground ULV foliar applications of the 4 Ib/gal SC/L at 1
        Ib ai/A followed by a second treatment at 0.5 Ib ai/A-  Data should
        be collected for forage and hay on the day of the second application.

     o  Sufficient data are available for dilute foliar applications of the
        4 Ib/gal SC/L or the 80% SC/fe formulations; however,  the registrant
        must specify the method of application.

33 /  The available data do not support the established tolerances for
     trichlorfon residues in or rangeland grass forage and hay following
     use of the registered formulations at their maximum use rates.   The
     following additional data are required:

     o  Residue data are required for two aerial ULV applications of the
        1.5 Ib/gal RTU formulation at OA Ib ai/A-  Replicate forage and
        hay samples should be collected on the day of the final treatment.

     o  Data are required reflecting single aerial and ground applications
        of either the 50 or 80% SC/S.  Replicate forage and hay samples
        must be analyzed.

     o  The available residue data for ULV applications of the 4 Ib/gal
        SC/L formulation are inconsistent and additional data are needed.
        This must include replicate forage and hay samples following two
        aerial or ground treatments, the first at 1 Ib/aiA and the second
        at 0.5 Ib aiA-
                                         98

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                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry
          (continued)

34 /  The available data do not support the established tolerance for
     alfalfa and alfalfa hay following use of the registered formulations
     at their maximum registered rates; all registered formulation classes
     were not tested.  Residues were below the tolerances for the 50 and
     80% SC/S and the 4 Ib/gal SC^ (including ULV treatments).   The
     following additional data are required:

     o  Single broadcast soil applications with the 5% P/T or one of the G
        formulations at 1 Ib ai/& using ground equipment.  Sampling of both
        green and dried (hay) alfalfa should reflect the maximum current
        use pattern.

35/  Data submitted in support of the tolerance for alfalfa hay were
     translated to, and support the established tolerance for,  trichlorfon
     residues in or on birdsfoot trefoil hay for the following reasons:

     o  The growth characteristics and use patterns for birdsfoot trefoil
        are very similar to those of alfalfa.

     o  Translated data submitted in support of the established tolerance
        for alfalfa hay were adequate for the SC/6 and SC/L formulations.

     o  Residue levels of trichlorfon in or on birdsfoot trefoil hay are
        not anticipated to exceed the maximum levels found in or on alfalfa
        hay.

36/  The alfalfa data do not support the established tolerances for clover
     and clover hay because all the registered formulation classes were
     not tested.  Residues resulting from the use of the 50% SC/S and the
     4 Ib/gal SC/L formulations were found not to exceed the established
     tolerances.  The following additional residue data are required:

     o  Residue studies reflecting single broadcast soil applications
        with the 5% P/T formulation at 1 Ib ai/& using aerial equipment.
        Sampling of both green and dried (hay) clover shold reflect the
        maximum current use pattern.

37/  Insufficient data exist to support the established tolerance for
     trichlorfon residues in or on artichokes.  The available data were
     obtained using an invalid analytical procedure (acetylcholinesterase
     inhibition) and additional residue data must be generated using a
     valid procedure:

     o  Ground applications of a dust  (D) and, to support Section 24(c)
        uses, a granular (G) formulation at 2.5 Ib aiA-
                                         99

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                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry
          (continued)

38/ The available data do not support the established 0.1 ppm tolerance
     for trichlorfon residues in or on cottonseed;  all of the residue data
     submitted were generated using an invalid cholinesterase inhibition
     technique.  The following data are required:

     o  Foliar ULV treatments with the 4 Ib/gal SC/L at 0.5 Ib aiAi foliar
        treatments with one of the SC/fe or SC/L formulations at 1.5 Ib aiA»
        and soil treatments with one of the G formulations (bait) at 1.5 Ib
        aiA-  All formulations must be applied twice using aerial (SC/L or
        SC/fe) or ground (G) equipment; residues should be determined on
        both forage (since grazing is permitted) and seed at intervals
        which reflect the maximum current use pattern

     o  If residues are detected in the cottonseed, a fractionation study
        to determine residues in the following processed products is
        required:  meal,  hulls,  soapstock,  crude oil,  and refined oil.

39 / The available data do not support the established tolerance for
     flaxseed.  Residues resulting from the maximum registered application
     rate were below the tolerance for flaxseed; however, only the 50% SC/S
     was tested,  the method of application was unspecified and only single
     applications were made (three/season are permitted).  The available
     data do not support the established 1  ppm tolerance for flax straw
     because straw was not analyzed.  The following additional data are
     required:

     o  Residue data for flax straw following multiple (no less than three)
        applications of the 50 or 80% SC/3  formulation at 1 Ib aiA using
        ground and aerial equipment.

     o  Field trials in MN, TX,  and Manitoba,' Canada,  with one of the G
        formulations at 1 Ib aiA«  Soil and foliar applications must be
        made at three or more weekly intervals with ground and aerial
        equipment.

        Sampling of flaxseed should reflect the maximum current use pattern.
        Straw should be sampled after drying (for SC/L only).

     o  If residues are found in flax grain,  then the fractionation study
        requested for cottonseed will be sufficient to determine residues
        in meal (linseed) and hulls.

40 / The available data do not support the  established tolerance for
     safflower seed.  Data were submitted only for the 50% SC/3 formulation
     applied at 2 Ib aiA;  the method of application was not specified.
     Also,  of the four residue values submitted, one exceeded the tolerance
     by 0.5 ppm.   The processing study which was submitted for meal and
                                        100

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                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry
          (continued)

     crude and refined oil was unsuitable; safflower seed did not contain
     field-treated detectable residues.  The following additional data are
     required:

     o  Two applications (at 14 days prior to bloom and at bloom) of one of
        the SC^ formulations (foliar applications) at 1.5 Ib ai/A using
        aerial and ground equipment, and one of the G (bait) formulations
        at 1.5 Ib aiA using ground equipment.  Field test locations should
        include irrigated regions; alternatively, a label restriction
        against usage on irrigated crops may be proposed.

     o  If residues are found in safflower seed, the processing study
        requested for cottonseed will be adequate to determine residues in
        meal and oil; if residues in excess of those established for the
        r.a.c. are found in meal or oil, food /feed additive tolerances must
        be proposed.

41 /  The following data are required to assess the exposure of man to
     residues of trichlorfon in or on tobacco:

     o  Residue analyses on green tobacco harvested 3 days after the second
        of two foliar applications of the 4% G at 0.6 Ib aiA and one of
        the SC/5 formulations at 1 Ib ai/A-

     o  Residue analyses on green tobacco 3 days after the last of two soil
        applications of one of the G (bait) formulations at 1 Ib ai/A? the
        second application should be made when plants are approximately 2
        ft. tall.

     o  If residues in green tobacco are >0.1 ppm, pyrolysis products of
        trichlorfon must be characterized.

42 /  The available data do not support the established tolerance for
     trichlorfon in cattle meat, fat, and meat by-products.  Although the
     feeding studies and pour-on application data are adequate; the following
     additional data are required:

     o  A single high pressure spray application of the 80% SC/5 formulation
        (8 Ib aiAOO gal) and residue analyses on meat, fat, and meat by-
        products after a posttreatment interval of 14 days.

43 /  The available data do not support the established tolerance for
     trichlorfon in milk.  The feeding studies are adequate; however, the
     following additional datPi are required to reflect the dermal use.
                                        101

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                 Generic Data Requirements for Trichlorfon

§158.125  Residue Chemistry
          (continued)

     o  A single pour-on application of the 8% KIU formulation (0.5 fl.
        oz/100 Ib body weight but no more than 4 fl. oz/animal)  and residue
        analyses on milk samples taken twice daily for 7 days following
        application or until residues are <0.01 ppm.

44/  The available data indicate that there is no reasonable expectation of
     finite residues in eggs; therefore, no tolerance for trichlorfon
     residues in or on eggs will be required [40 CFR 180.6a(3)].  However,
     no data were submitted pertaining to residues of trichlorfon in or on
     poultry meat (muscle, liver, kidney, and fat) resulting from ingestion
     of trichlorfon residues at the maximum expected dietary intake level;
     therefore, the following additional data are required:

     o  Poultry feeding studies at 5, 15, and 50 ppm for 28 consecutive
        days and subsequent residue analyses on poultry meat (muscle, liver,
        kidney, and fat) from animals slaughtered within 24 hours of the
        final feeding.  If the requested metabolism data reveal  no additional
        residues of concern and if the requested ruminant residue studies
        indicate that residues are nondetectable, then the above poultry
        feeding studies will be waived.

45/  No valid data are available to support the tolerance for sugar beet
     tops; all residue data submitted were generated with an invalid
     cholinesterase inhibition technique.  The following data are required:

     o  Foliar treatments with one of the SC/L or SC/S formulations at 1.5
        Ib/A and subsequent residue analysis on tops which reflect the
        maximum current use pattern.
                                      102

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                TABLE A
GENERIC DATA REQUIREMENTS FDR TRICHLORPON
Data Requirement
§158.130 Environmental Fate
DEGRADATION STUDIES-LAB:
161-1 - Hydrolysis
Photodegradat ion
161-2 - In water
161-3 - On soil
161-4 - In Air
METABOLISM STUDIES-LAB:
162-1 - Aerobic Soil
162-2 - Anaerobic Soil
162-3 - Anaerobic Aquatic
162-4 - Aerobic Aquatic
MOBILITY STUDIES:
163-1 - Leaching and Ad-
sorption /Desorpt ion
163-2 - Volatility (Lab)
163-3 - Volatility (Field)
V
Composition
TGAI or PAIRA

TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TEP
TEP
Does EPA Have Data
To Satisfy This
Use 2/ Requirement? (Yes, Bibliographic
Pattern No or Partially) Citation
A,B,D,E,F,G,H
-
A,B,D,G
A,G
A,E,F
A,B,E,F,G,H
A
D,G
D,G
A,B,D,E,F,G,H
A
A
No

No
No
No
Yes GS0104080
No5/
No
No
Partial6/ 00068214
No
No
Must Additional
Data be Submitted
Under FIFRA Section
3(c)(2)(B)?
Yes3a/

Yes3a/
Yes39"/
Yes2f/,V
No
Yes39/
Yes3/
Yes3/
Yes3^/
YesV
Reserved^/
                     103

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                                                     TABLE A
                                      GENERIC DATA REQUIREMENTS  FDR TRICHLORFDN
Data Requirement
Conposition
    Use  £/
  Pattern
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
  Citation
Must Additional
Data be Submitted
 Under FIFRA Section
  3(c)(2)(B)?
§158.130 Environmental Fate
         (continued)

  DISSIPATION STUDIES-FIELD;

  164-1 - Soil
  164-2 - Aquatic (Sediment)
  164-3 - Forestry
  164-4 - Combination and
           Tank Mixes
  164-5 - Soil, Long-term

  ACOJMULATION STUDIES:
    TEP
    TEP
    TEP
    TEP

    TEP
A,B,H
D
G
  165-1 - Rotational Crops
           (Confined)
  165-2 - Rotational Crops
           (Field)
  165-3 - Irrigated Crops
  165-4 - In Fish
  164-5 - In Aquatic Non-
           Target Organisms
   PAIRA

    TEP

    TEP
TGAI or PAIRA
    TEP
A,B,D,G
A,B,D.G
      No
    Partial
    Partial^/
  Not Applicable

      No
      No

      No

  Not Applicable
      No
      Yes
00091852
00092002
00092002
                                                    YesV

                                                 Reserved12/
     Yes3/,lV
     Yes7/
                                                           104

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                           TABLE A
          Generic Data Requirements For Trichlorfon

158.130  Environmental Fate
          (continued)

V  Composition:  TGAI = Technical grade of the active
    ingredient; PAIRA = Pure active ingredient, radiolaheled;
    TEP = Typical end-use product.

_£/  The use patterns are coded as follows:
    A = Terrestrial, Food Crop; B = Terrestrial, Non-Food;
    C = Aquatic, Food Crop; D = Aquatic, Non-Food; F = Greenhouse,
    Food crop; F = Greenhouse, Non-Food; G = Forestry;
    H = Domestic Outdoor; I = Indoor.

2/  Data must he submitted no later than  June, 1987	.

3 a/ The Agency is concerned about the potential contamination of
    ground water by trichlorfon and its metabolites.  Data re-
    quired for the evaluation of the potential for contamination
    are being required on an accelerated basis.  These data will
    be required to be submitted as follows:

     0 Hydrolysis (161-1), Photodegradation (161-2 ,-3 ,-4 ) , and
         Mobility (163-1) must be submitted no later than
         December, 1984.	.

     0 Soil Metabolism (162-1,-2), Field Dissipation  (164-1,
         -3) must be submitted no later than June, 1986
^J  Not required unless used in greenhouses.

_|V  The anaerobic aquatic metabolism data may be substituted
    for the anaerobic soil metabolism data, but the reverse is
    not permissible.

£/  Study (00068214) partially fulfills mobility data require-
    ments for terrestrial, food crop; terrestrial, non-food;
    and forestry use patterns, by providing information on the
    rapid leaching of trichlorfon in five soil types by soil
    thin layer chromatography.  To satisfy mobility data
    requirements for terrestrial, food crop; terrestrial, non-
    food; and forestry use patterns, an additional study in
    which the mobility of trichlorfon aged in a sandy loam soil
    is assessed by using either soil TLC or soil column
    techniques is required.  Additional, adsorption/desorption
    (batch equilibrium) studies are required on four soils,
                                105

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     preferably a sand (agricultural), sandy loam, silt loam,
     clay or clay loam for domestic outdoor and greenhouse uses
     and on one aquatic sediment obtained from, or representative
     of, the aquatic use area for aquatic non-food crop use
     pattern.

 ]_/  Data requirement depends on the results of the laboratory
     studies.

 £/  Terrestrial field dissipation studies are required for:
     (1) terrestrial, food crop uses;  representative use pattern
     sites should include field vegetable crops, orchard crop
     (citrus) and pasture grasses, (2) terrestrial, non-food
    ' uses; representative use pattern sites should include
     tobacco and turf (golf courses) and, (3) domestic outdoor
     uses; representative use pattern sites should include
     lawns.

 V  Study (00091852) partially fulfills field dissipation-
     aquatic (sediment) data requirements by providing infor-
     mation showing that the SC/S formulation of trichlorfon
     did not persist in fish rearing pond water or in mud
     under alkaline conditions.  Two additional aquatic field
     dissipation studies are required for two different fish
     rearing ponds under acidic conditions (pH 5-6) which are
     representative of the fish rearing ponds for which there
     is a registered parasiticide use.


 1°/ Study (00092002) was reviewed and is considered scientifi-
     cally valid.  However, this study was conducted with the
     SC/S formulation of trichlorfon,  which is not currently
     registered for forestry use.  Therefore forestry dissipa-
     tion studies are required for the end-use product with
     the largest amount of trichlorfon for which there is a
     registered use.

H/  No data were submitted; however,  the data requirements
     are waived based on the aerobic soil metabolism study
     which demonstrated that £50% of the trichlorfon initially
     appplied would be present in soil when a subsequent
     application would occur.

12/  Reserved pending results of 165-1.

13/  This data requirement depends on the results of 63-11 and
     161-1.  No data on the accumulation of trichlorfon in fish
     will be required if trichlorfon has a half-life of less
     than 4 days in water or an octanol water partition coeffi-
     cient of less than 1000.
                                 106

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                                                           TABLE A
                                             GENERIC DATA REQUIREMENTS FOR TRICHLORFON
      Data Requirement
Composition
                   Does EPA Have Data
                   To Satisfy This
V    Use    £/    Requirement? (Yes,    Bibliographic
      Pattern	No or Partially)	Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
158.135 Toxicology

ACUTE TESTING;

81-1 - Acute Oral Toxicity - Rat    TGAI
81-2 - Acute Dermal Toxicity        TGAI
        Rabbit
81-3 - Acute Inhalation Toxicity    TGAI
        - Rat

81-7 - Delayed                      TGAI
       Neurotoxicity - Hen

SUBCHRONIC TESTING;

82-1 - 90-Day Feeding -             TGAI
        Rodent, Non-rodent

82-2 - 21-Day Dermal Rabbit         TGAI

82-3 - 90-Day Dermal Rabbit         TGAI

82-4 - 90-Day Inhalation -          TGAI
        Rat

82-5 - 90-Day Neurotoxicity -       TGAI
        Hen/Mammal
                 A,B,D,E,F,G,H     Yes
                 A,B,D,E,F,G,H     Yes
                 A,B,D,E,F,H
                 A,E
                        NO
                 A,B,D,E,F,G,H     Yes
                        No
                 A,B,D,E,F,G,H     No

                 A,B,D,E,F,G,H     No

                 A,B,D,E,F,G,H     No


                 A,B,D,E,F,G,H     No
                                        00081186
                                        00005494
                                        GS0104069
                                        GS0104070
                                        GS0104071

                                        GS0104072
                                        GS0104069
                                        GS0104070
                                        GS0104073
     No
     No
     Yes
     No
     Yes


     Yes

     Yes

     Yes


     Yes
                                                                107

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                                                           TABLE A
                                             GENERIC DATA REQUIREMENTS FOR TRICHLORFON
      Data Requirement
Composition
                   Does EPA Have Data
                   To Satisfy This
\/    Use 2/       Requirement? (Yes,
      Pattern	No or Partially)
Bibliographic
  Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
§158.135 Toxicology
        (continued)

CHRONIC TESTING;

83-1 - Chronic Toxicity -           TGAI

83-2 - Oncogenicity -               TGAI
        2 species:  Rat and
        mouse preferred

83-3 - Teratogenicity -             TGAI
        2 species
83-4 - Reproduction - Rat           TGAI
        2-generation

MUTAGENICITY TESTING;

84-2 - Gene Mutation                TGAI

84-2 - Chromosomal Aberration       TGAI

84-2 - Other Mechanisms of          TGAI

        Mutagenicity
                 A,B,,D,E,F,G,H     No

                 A,B,D,E,F,G,H     No



                 A,B,D,E,F,G,H     Partial



                 A,B,D,E,F,G,-H     Yes
                 A,B,D,E,F,G,H     Yes

                 A,B,D,E,F,G,H     No

                 A,B,D,E,F,G,H     Yes
                                         00063192 V
                                        GS0104074
                                        GS0104075

                                        GS0104076
                                        00028625
                                        GS010477
                                        00028625
                                        GS0104077
                                        GS0104078
                                        GS0104079
                       Yesf/

                       Yes



                       YesV



                       No
                       No

                       Yes

                       No
                                                                 108

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                                                           TABLE A
                                             GENERIC DATA REQUIREMENTS FDR TRICHLORFON
                                                              Dees EPA Have Data                   Must Additional
                                                              To Satisfy This                      Data Be Submitted
                                           \/    Use 2/       Requirement? (Yes,   Bibliographic   Under FIFRA Section
	Data Requirement	Composition	Pattern	No or Partially)	Citation	3(c) (2) (B)?3/	


SPECIAL TESTING;

85-1 - General Metabolism          PAI or        A,B,D,E,F,G,H     No                  -                  Yes
                                   PAIRA
85-2 - Domestic Animal Safety      Choice        A,B,D,G,H         No                  -                  Yes
V  Composition:  TGAI = Technical grade of active ingredient; PAI = Pure active ingredient; PAIRA = Pure active
    ingredient, radiolabeled; Choice = Choice of several test substances determined on a case-by-case basis.
2/  The use patterns are coded as follows:  A = Terrestrial, Food Crop; B = Terrestrial, Non-Food; C = Aquatic,
    Food Crop; D = Aquatic, Non-Food; E = Greenhouse, Food Crop; F = Greenhouse, Non-Food; G = Forestry; H =
    Domestic Outdoor; I = Indoor.
V  Data must be submitted no later than     June .  1 987	•
_4/  Two species are required: one rodent, rat preferred; and one non-rodent which must be the dog.
5/  The gavage portion of this study is valid but the feeding portion is considered inadequate.
6/  Data from an adequate dietary study in the rat must be submitted.
                                                                 109

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                                                           TABLE A
                                             GENERIC DATA REQUIREMENTS FDR TRICHLORFON
                                                              Does EPA Have Data
                                                              To Satisfy This
                                           V    Use 2/       Requirement? (Yesf   Bibliographic
Must Additional
Data Be Submitted
Under FIFRA Section
Data Requirement
§158.140 Reentry Protection
132-1 - Foliar Dissipation
132-1 - Soil Dissipation
133-3 - Dermal Exposure
133-4 - Inhalation Exposure
Composition

TEP
TEP
TEP
TEP
Pattern

A,B,D,G
A,B,D,G
AfB,D,G
A,B,D,G
No or Partially)

No
No
No
No
Citation 3(c)(2)(B)?V

No
No
No
No
_!/  Composition:  TEP = Typical end-use product
2/  The use patterns are coded as follows:  A = Terrestrial, Food Crop; B = Terrestrial, Non-Food; C = Aquatic,
    Food Crop; D = Aquatic, Non-Food; E = Greenhouse, Food Crop; F = Greenhouse, Non-Food; G = Forestry; H =
    Domestic Outdoor; I = Indoor.
3/  No data were submitted; however, data are not being required at this time because the toxicity of trichlorfon does
    not exceed subpart K requirements for reentry.  These data may be required after other data required under this
    standard have been reviewed and evaluated.
                                                                   110

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                TABLE A
GENERIC DATA REQUIREMENTS FOR TRICHLORFON
Does EPA Have Data Must Additional
To Satisfy This Data be Submitted
V Use 2/ Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition Pattern No or Partially) Citation 3(c) (2) (B)?3/
§158.145 Wildlife and
Aquatic Organisms
AVIAN AND MAMMALIAN TESTING
71-1 - Acute Avian Oral TGAI A,B,G Yes 00073683
Toxicity
71-2 - Avian Subacute Dietary TGAI A,B,G,I Yes 00034769
Toxicity
71-3 - Wild Mammal Toxicity TGAI A,B,G Not Required
71-4 - Avian Reproduction TGAI A,B,G Not Required
71-5 - Simulated and Actual TEP A,B,G Not Required
Field Testing -
Mammals and Birds
AQUATIC ORGANISM TESTING
72-1 - Freshwater Fish TGAI A,B,D,G,I Yes 00091881
Acute Toxicity 00091766
GS0104081
00065495
-do- TEP D,G Yes 00091766
GS0104081

No

No




No

No

                    111

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                                                     TABLE A
                                      GENERIC DATA REQUIREMENTS FOR TRICHLORFON
Data Requirement
Composition
           V
               Use
             Pattern
                                                         Does EPA Have Data                 Must Additional
                                                         To Satisfy This                    Data be Submitted
                                                         Requirement? (Yes,  Bibliographic  Under FIFRA Section
                                                         No or Partially) _ Citation _ 3(c) (2) (B)?3/
§158.145 Wildlife and
  Aquatic Organisms
   (continued)

  72-2 - Acute Toxicity to       TGAI
          Freshwater
          Invertebrates

              -do-               TEP

  72-3 - Acute Toxicity          TGAI
          Estuarine and
          Marine Organisms

  72-4 - Fish Early Life         TGAI
          Stage and Aquatic
          Invertebrate Life-Cycle

  72-5 - Fish - Life-Cycle       TGAI
             A,B,D,C,I
                               Yes
             D,G            Yes

             A,B,D,G    Not Required
             A,B,D,G
             A,B,D,G
  72-6 - Aquatic Organism
          Accumulation
TGAI, PAR or
Degradation  A,B,D,E
 Product
  72-7 - Simulated or Actual     TEP
         Field Testing -
         Aquatic Organisms
             A,B,D,G
                                No
                                No
                                No
                                No
                                                                             GS0104081
                                               GS01040R1
No
                                                                                                  No
                                                                                                  YesV



                                                                                               Reserved _•>/


                                                                                               Reserved _5/


                                                                                               Reserved *V
                                                           112

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                           Table A
          Generic Data Requirements for Trichlorfon

158.145 Wildlife and Aquatic Organisms
          (continued)

!_/  Composition:  TGAI = Technical grade of the active ingre-
    dient; PAI = pure active ingredient; TEP = Typical end-
    use product;

2_l  The use patterns are coded as follows:  A = Terrestrial,
    Food Crop; B = Terrestrial, Non-Food Crop; C = Aquatic
    Food Crop; D = Aquatic, Non-Food Crop; E = Greenhouse,
    Food Crop; F = Greenhouse, Non-Food; G = Forestry; H =
    Domestic Outdoor; I = Indoor.

3y  Data must be submitted no later than  June ,  1 987

4_/  Data requirement is limited to the aquatic invertebrate
    life cycle test; use patterns - A,B,D,E.

_5/  Reserved pending submission of appropriate environmental
    fate studies (e.g., dissipation and hydrolysis studies)
    which are needed to determine if hazardous concentrations
    of trichlorfon will reach or accumulate in the aquatic
    environment when products are used as directed.

6/  Reserved pending results of 72-4.
                                 113

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                                                      TABLE A
                                     GENERIC DATA REQUIREMENTS FDR TRICHLORPON
Data Requirement
Conposition
                   Does EPA Have Data                Must Additional
                   To Satisfy This                   Data be Submitted
V        Use  £/  Requirement? (Yes,  Bibliographic Under FIFRA Section
        Pattern    No or Partially)	Citation	3(c) (2) (B)?3/
§158.150 Plant Protection

  121-1 - TARGET AREA             EP
           PHYTOTOXICITY

  NONTARGET AEA PHYTOTOXICITY

          TIER I

  122-1 - Seed Germination/     TGAI
          Seedling Emergence
                                    No
                                    No
                                                          No 4/
                                                          No V
122-1
122-2
123-1
123-1
123-2
124-1
124-2
- Vegetative Vigor
- Aquatic Plant Growth
TIER II
- Seed Germination/
Seedling Emergence
- Vegetative Vigor
- Aquatic Plant Growth
TIER III
- Terrestrial Field
- Aquatic Field
TGAI
TGAI
TGAI
TGAI
TGAI
TEP
TEP
No
No
No
No
No
No
No
No 4/
No J/
No £/
No 4/
No £/
No V
NoJ/
V  Composition:  TGAI = Technical grade of the active ingredient; TEP = Typical end-use product.
    EP = End-use product.
£/  The use patterns are coded as follows:  A = Terrestrial, Food Crop; B = Terrestrial, Non-Food Crop;
    C = Aquatic, Food Crop; D = Aquatic, Non-Food; E = Greenhouse, Food Crop; F = Greenhouse, Non-Food;
    G = Forestry; H = Domestic Outdoor; I = Indoor.
V  Reserved.
"*/  These requirements are generally not required unless it is believed there is a phototoxicity problem.
                                                             1 1 A

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                                                      TABLE A

                                      GENERIC DATA REQUIREMENTS FDR TRICHLORFON
Data Requirement
           V    Use
Composition    Pattern
                                                        Does EPA Have Data                Must Additional
                                                        To Satisfy This                   Data be Submitted
                                                        Requirement? (Yes, Bibliographic  Under FIFRA Section
                                                        No or Partially) _ Citation _ 3(c) (2) (B)?3/
§158.155 Nontarget Insect

  NONTARGET INSECT TESTING -
  POLLINATORS;

  141-1 - Honey bee acute
           contact
  141-2 - Honey bee - toxicity
           of residues on
           foliage
  TGAI

   TEP
                                             A,B,G,H

                                             A,B,G,H
  141-3 - Wild bees important in
          alfalfa pollination -
          toxicity of residues
          on foliage             TEP

  141-4 - Honey bee subacute
           feeding study      [Reserved]  V
               A,B,G,H
  141-5 - Field testing for
           pollinators
   TEP
                                             A,B,G,H
Yes

Yes
00036935

00060628,
05000837
                                                         Not Required
Yes
05004412
No

No
No
                                                           115

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                                                      TABLE A
                                     GENERIC DATA REQUIREMENTS FOR TRICHLORPON
Data Requirement
                                     Use2/
                    Composition1/  Pattern
Does EPA Have Data                Must Additional
To Satisfy This                   Data be Submitted
Requirement? (Yes, Bibliographic  Under FIFRA Section
No or Partially)	Citation	3(c) (2) (B)?3/
§158.155 Nontarget Insect
       (continued)

  NONTARGET INSECT TESTING -
  AGUATIC INSECTS

  142-1 - Acute toxicity to
           aquatic insects

  142-2 - Acute insect
          life-cycle study
                    [Reserved]  V


                    [Reserved]  5/
  142-3 - Simulated or actual
           field testing for
           aquatic insects     [Reserved]
  143-1 - NONTARGET INSECT TESTING -
  thru
  143-3
PREDATORS AND PARASITES
                    [Reserved] V
_!/  Composition:  TGAI = Technical grade of the active ingredient; TEP = Typical end-use product.
    EP = End-use product.
2/  The use patterns are coded as follows:  A = Terrestrial, Food Crop; B = Terrestrial, Non-Food Crop;
    C = Aquatic, Food Crop; D = Aquatic, Non-Food; E = Greenhouse, Food Crop; F = Greenhouse, Non-Food;
    G = Forestry; H = Domestic Outdoor; I = Indoor.
V  Reserved.
4/  Reserved pending development of test methodology.
V  Reserved pending Agency decision as to whether the data requirements should be established.
                                                           116

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Ill.   REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA

    Note:  This Section applies only to manufacturing-use
products, not end-use products.

    A necessary first step in determining which statements must
appear on your product's label is the completion and submission
to EPA of product-specific data* listed on the form entitled
"Product Specific Data Report" (EPA Form 8580-4, Appendix III-l)
to fill "gaps" identified by EPA concerning your product.  Under
the authority of FIFRA Section 3(c)(2)(B), EPA has determined
that  you must submit these data to EPA in order to register or
reregister your product(s).  All of these data must be submitted
not later than six months after you receive this guidance document

    "Product-Specific Data Requirements for Manufacturing-Use
Products" appearing in Table B permit you to determine which
product-specific data you must submit.  This can be done by
examining the entries in the column of those tables entitled
"Must Data Be Submitted Under S3(c)(2)(B)."
     V Product specific data pertains to data that support the
formulation which is marketed; it usually includes product chemist)y
data and acute toxicology data.
                                117

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                                                     TABLE B
             PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING TRICHLOFON
§158.120 - PRODUCT CHEMISTRY
Guideline Citation and                 Test          Guidelines       Are Data              Footnote
Name of Test                         Substance V      Status         Required V            Number
	Yes	No	

PRODUCT IDENTITY:

61-1 - Identity of Ingredients         MP                R         /X/       /~7          	

61-2 - Statement of Composition        MP                R         /X/       /~7          	
61-3 - Discussion of Formation of      MP                R         /X/       / /
       Ingredients

Analysis and Certification of Product
Ingredients

62-1 - Preliminary Analysis            MP                R         /X/       _/~7

62-2 - Certification of Limits         MP                R         /X/       f~J
62-3 - Analytical Methods for          MP                R         /X/       /_/
        Enforcement of Limits

Physical and Chemical Characteristics


63-2 - Color                           MP                R         /X/       /~7

63-3 - Physical State                  MP                R         /X7       7~7

63-4 - Odor                            MP                R         /V       /~7

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                                                     TABLE B
             PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING TRICHLORPON
§158.120 - PRODUCT CHEMISTRY (Con't)
Guideline Citation and Test Guidelines
Name of Test Substance V Status
Physical and Chemical Characteristics
(Continued)
63—7 Density f Bulk Density, or
Specific Gravity
£O TO _ T-*H

63 14 Oxidizing or Reducing
Action
63-15 - Flammability
63-16 - Explodability
DJ i i storage otauiiity
DJ 10 — viscosity
63 19 Miscibility
63—20 Corrosion Characteristics
Other Requirements:

64—1 SuDmittal of samples
MP R
MP R
MP CR
MP CR
MP R
MP R
MP CR '
MP CR
MP R
PAI CR
I/ Composition: MP = Manufacturing-Use Prouct; PAI = Pure Active
2/ Data must be submitted no later than December, 1984
Are Data Footnote
Required 2/ Number
Yes No
/v n
/v n
A/ n
ffl f~7
/xz n
/w n
/xz n
A/ n
/*/ n
n /v

Ingredient1
                                                                 1.19

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                                                     TABLE B
             PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING TRICHLORFON
                                           V
             Does EPA Have Data
             To Satisfy This
             Requirement? (Yes,
                Bibliographic
Must Additional
Data Be Submitted
Under FIFRA Section
Data Requirement Composition
158.135 Toxicology
ACUTE TESTING:
81-1 - Oral LD5Q - Rat MP
81-2 - Dermal 11)50 - Rabbit MP
No or Partially) Citation
Yes 00081186
00005494
GS0104069
GS0104070
GS0104071
Yes ' GS0104072
GS0104069
GS0104070
3(c)(2)(B)?2/
No
No
81-3 - Inhalation IC$Q - Rat

81-4 - Primary Eye
        Irritation - Rabbit

81-5 - Primary Dermal
        Irritation - Rabbit

81-6 - Dermal Sensitization -
        Guinea Pig
MP

MP


MP


MP
No

No


No


No
     Yes

     Yes


     Yes


     Yes
_!/  Composition:  MP = Manufacturing product
2/  Data must be submitted no later then  te C3 mbe r ,  1 984  •
                                                             120

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IV.  SUBMISSION OF REVISED LABELING AND PACKAGING INFORMATION

    Note:  This section applies to end-use products only to the
the extent described under Section II of this document.
Otherwise, the following information pertains exclusively to
manufacturing-use products.

    The Agency requires applicants for registration or reregistra-
tion to ensure that each label (1) contains accurate, complete,
and sufficient instructions and precautions, reflecting the
results of data concerning the product and its ingredients, and
(2) incorporates labeling format and terminology which are suffi-
ciently standardized to avoid user confusion.

    As part of your application, you will be required to submit
draft labeling consistent with:  applicable product-specific
data; the precautionary statements and use directions; and the
regulations concerning classification [40 CFR Sl62.11(c)], pack-
aging [40 CFR §162.16], and labeling [40 CFR §162.10, Appendix
IV-1 an IV-2], as indicated by the following paragraphs of this
chapter of the guidance document.

    If owners of currently registered products fail to submit
revised labeling and packaging information complying with this
Section and/or Section II, EPA may issue a notice of intent to
cancel the registration under FIFRA §6(b)(l).

    A.  Label Contents

        40 CFR §162.10 (Appendix IV-1) requires that certain spe-
    cific labeling statements must appear at certain locations
    on the label.  This is referred to as format labeling.
    Specific label items listed below are keyed to Tables D, E,
    and F (Appendix IV-2).

        Item 1.  PRODUCT NAME - The name, brand, or trademark is
    required to be located on the front panel, preferably centered
    in the upper part of the panel.  The name of a product will
    not be accepted if it is false or misleading.  See Appendix
    IV-1.  [40 CFR §162.10(b)]

        Item 2.  COMPANY NAME AND ADDRESS - The name and address
    of the registrant or distributor is required on the label.
    The name and address should preferably be located at the
    bottom of the front panel or at the end of the label text.
    See Appendix IV-1.  [40 CFR §162.10(c)]

        Item ?..  NET CONTENTS - A net content statement is required
    on all labels.  The preferred location is the bottom of the
    front panel immediately above the company name and address,
    or at the end of the label text.  The net contents must be
    stated in terms of weight, expressed as avoirdupois pounds
                               121

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and ounces, and stated in terms of the largest suitable unit,
i.e., "1 pound 10 ounces" rather than "26 ounces."  In
addition to the required units specified, net contents may be
expressed in metric units.  See Appendix IV-1.  [40 CFR
S162.10(d)]

    Item 4.  EPA REGISTRATION NUMBER - The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase "EPA Registration No.," or "EPA
Reg. No."  The registration number must be set in type of a
size and style similar to other print on that part of the
label on which it appears and must run parallel to it.  The
registration number and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency.  See Appendix IV-1.
[40 CFR S162.10(e)]

    Item 5.  EPA ESTABLISHMENT NUMBER - The EPA establishment
number, preceded by the phrase "EPA Est." is the final estab-
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment registration number on
the immediate container cannot be clearly read through such
wrapper or container.  See Appendix IV-1.  [40 CFR S162.10(f)]

    Item 6.  INGREDIENT STATEMENT - An ingredient statement
is required on the front panel and must contain the name and
percentage by weight of each active ingredient and the total
percentage by weight of all inert ingredients.  The preferred
location is immediately below the product name.  The ingredient
statement must run parallel with, and be clearly distinguished
from, other text on the panel.  It must not be placed in the
body of other text.  See Appendix IV-1.  [40 CFR 162.10(g)]

    Item 6A.  POUNDS PER GALLON STATEMENT - For liquid
agricultural formulations, the pounds per gallon of active
ingredient must be indicated on the label.

    Item 7.  FRONT LABEL PRECAUTIONARY STATEMENTS - All labels
are required to have precautionary statements grouped together
on the front panel, preferably within a block outline.  The
table below shows the minimum type size requirements on
various size labels, as set forth in the Regulations.
                           122

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Size of Label
on Front Panel
in Square Inches

5 and under
above 5 to 10
above 10 to 15
above 15 to 30
over 30
        Signal Word as Re-
        quired Minimum Type
        Size All Capitals

              6 point
             10 point
             12 point
             14 point
             18 point
"Keep Out of Reach
    of Children"
	as Required

     6 point
     6 point
     8 point
    10 point
    12 point
    Item 7A.  CHILD HAZARD WARNING STATEMENT - All labels are
required to have the statement "Keep Out of Reach of Children"
located on the front panel above the signal word except where
contact with children during distribution or use is unlikely.
See Appendix IV-1.  [40 CFR §162.10(h)(1)(ii))

    Item 7B.  SIGNAL WORD - The signal word (Caution, Warning,
or Danger) is required on the front panel immediately below
the child hazard warning statement.  See Appendix IV-1.
[40 CFR §162.10 (h)(l)(i)]

    Item 7C.  SKULL & CROSSBONES AND WORD "POISON" - On products
assigned a toxicity Category I on the basis of oral, inhala-
tion, or dermal toxicity, the word "Poison" shall appear on
the label in red on a background of distinctly contrasting
color and the skull and crossbones shall appear in immediate
proximity to the word poison.  See Appendix IV-1.  [40 CFR
 STATEMENT OF PRACTICAL TREATMENT - A statement
treatment (first aid or other) shall appear on
pesticide products in toxicity Categories I,
 See Appendix IV-1.  [40 CFR 5162,10(h)(1) (iii)]
    Item 7D.
of practical
the label of
II, and in.
    Item 7E.  REFERRAL STATEMENT - The statement "See Side
(or Back) Panel for Additional Precautionary Statements" is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
See Appendix IV-1.  [40 CFR §162.10(h)(1)(iii)]

    Item 8.  SIDE/BACK PANEL PRECAUTIONARY LABELING - The
precautionary statements as listed below must appear together
on the label under the heading "PRECAUTIONARY STATEMENTS."
The preferred location is at the top of the side or back
panel preceding the directions for use,  and it is preferred
that these statements be surrounded by a block outline.  Each
of the three hazard warning statements must be headed by the
appropriate hazard title.  See Appendix IV-1.  [40 CFR §162.10
                           123

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    Item 8A.  HAZARD TO HUMANS AND DOMESTIC ANIMALS - Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions taken to avoid
accident, injury or damage.  See Appendix IV- 1.  [40 CFR S162.10
    Item 8B.  ENVIRONMENTAL HAZARD - Where a hazard exists to
non-target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage.  See Appendix IV- 1.  [40 CFP
    Item 8C.  PHYSICAL OR CHEMICAL HAZARD

    1.  Flammability statement.  Precautionary statements
        relating to flammability of a product are required
        to appear on the label if it meets the criteria in
        Appendix IV-3.  The requirement is based on the results
        of the flashpoint determinations and flame extension
        tests required to be submitted for all products.
        These statements are to be located in the side/back
        panel precautionary statements section, preceded by
        the heading "Physical/Chemical Hazards."  Note that
        no signal word is used in conjunction with the flam-
        mability statements.

    2.  Criteria for declaration of non-f lammability .  The
        following criteria will be used to determine if a
        product is non-flammable:

        a.  A "non-flammable gas" is a gas (or mixture of
            gases) that will not ignite when a lighted match
            is placed against the open cylinder valve.

        b.  A "non-flammable liquid" is one having a flash-
            point greater than 350°F (177°C) as determined
            by the method specified in 40 CFR §163 .61-8 (c) ( 13 )
            ( ii) of Subpart D.

        c.  A "non-flammable aerosol" is one which meets the
            following criteria:

            i.  The flame extension is zero inches, using the
                method specified in 40 CFR S163 .61-8 ( c) ( 13 ) ( ii ) ;

           ii.  There is no flash back; and

          iii.  The flashpoint of the non-volatile liquid
                component is greater than 350°F (177°C),
                determined by the method specified in 40 CFR
                S163.61-8(c)(13)(i).
                           124

-------
    3.  Declaration of non-flammability.   Products which meet
        the criteria for non-flamroability specified above may
        bear the notation "non-flammable" or "nonflammable
        (gas, liquid, etc.)" on the label.

        It may appear as a substatement to the ingredients
        statement, or on a back or side panel, but shall not
        be highlighted or emphasized (as  with an inordinately
        large type size) in any way that  may detract from
        precaution.

    4.  Other physical/chemical hazard statements.  When
        chemistry data submitted in accordance with 40 CFR
        §163,61-10(c) demonstrate hazards of a physical or
        chemical nature other than flammability, appropriate
        statements of hazard will be prescribed.  Such
        statements may address hazards of explosivity,
        oxidizing or reducing capability, or mixing with
        other substances to produce toxic fumes.

    Item 9.  MISUSE STATEMENT - The following statement is
required on your label:  "It is a violation of Federal law to
use this product in a manner inconsistent with its labeling."
See Appendix IV-1.   [40 CFR §162.10(1)(2)(ii)]

    Item 10A.  STORAGE AND DISPOSAL BLOCK -  All labels are
required to bear storage and disposal statements.  These
statements are developed for specific containers, sizes, and
chemical content.  Make certain that the  statement you use
pertains specifically to your product.  These instructions
must be grouped and appear under the heading "Storage and
Disposal" in the directions for use.  This heading must be
set in the same type sizes as required for the child hazard
warning.  Refer to Appendix IV-5 for the  latest specific
storage and disposal product label statements.

    Item 10B.  DIRECTIONS FOR USE - Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide.  When followed, directions must be adequate to
protect the public from fraud and from personal injury and to
prevent unreasonable adverse effects on the environment.  See
Appendix IV-1.  [40 CFR S162.10]

B.  Collateral Information

    Bulletins, leaflets, circulars, brochures, data sheets,
flyers, and other graphic printed matter  which is referred to
on the label or which is to accompany the product are termed
collateral labeling.  Such labeling ma^ not bear claims or
representations that differ in substance  from those accepted
in connection with registration of the product.  It should be
made part of the response to this notice  and submitted for review.
                           125

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V.     INSTRUCTIONS FOR SUBMISSION

     All applications  prepared  in response to  this Notice should
be  addressed  as follows:

     Product Manager William H.  Miller
     Phone No.  (703)   557-2600
     Registration Division  (TS-767)
     Office of  Pesticide Programs
     Environmental Protection Agency
     Washington, D.C.   20460

For each product for  which continued registration is  desired:

     1.   Within 90 days from receipt of this document,  you must
         submit the "FIFRA Section 3(c)(2)(B)  Summary  Sheet" EPA
         Form  8580-1.   Refer to Appendix II-2  with appropriate
         attachments.

     2.   Within 6 months from  receipt of this  document  registrants
                   must  submit:

                   a.  Confidential Statement of Formula, EPA Form 8570-4.

                   b.  Product Specific Data Report,  EPA Form 8580-4  (Appendix
                      III-l).

                   c.  Two copies  of any required product-specific data.

                   d.  Two copies  of draft labeling,  including the label and
                      associated  brochures.   If current labeling conforms
                      to the requirements of this guidance document  and the
                      results of  the short-term data, the registrant may
                      submit such labeling.   (End-use product labeling
                      needs to comply specifically with the instruction in
                      Section II  of this guidance document.) The labeling
                      should be either typewritten text on 8-1/2 x 11 inch
                      paper or a  mcckup of the labeling suitable for
                      stortage in 8-1/2 x 11 inch files. The draft label
                      must indicate the intended colors of the final label,
                      clear indication of the front  panel label, and the
                      intended type sizes of the text.

               3.  Within the time set forth in Table A, all generic  data
                   must  be submitted by the affected  registrant(s).

           Note;  If for any reason any required test is delayed or aborted
                  so that meeting the agreed submission time will be  delayed,
                  notify the Product Manager listed above.

               After the Supreme Court has ruled on the Monsanto Decision,
           you will be informed as to when you must submit your Application
           for Amended Pesticide Registration (EPA Form 8570-1) and the
           associated data support information.
                                   126

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                                                              APPENDIX  II-l
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
               Registration Under the Trichlorfon Standard
00005296      Arthur, B.W.; Casida, J.E. (1957) Metabolism and selectivity of O,
                 O-Dimethyl 2,2,2-trichloro-l-hydroxyethyl phosphonate and its
                 acetyl and vinyl derivatives.  Journal of Agricultural and Food
                 Chemistry 5(3):186-192.  (Also In unpublished submission re-
                 ceived Aug 18, 1966 under 7F0612; submitted as report number
                 1241 by Chemagro Corp., Kansas City, Mo.; CDL:090796-U)

00005297      Robbins, W.E.; Hopkins, T.L.; Eddy, G.W. (1956) The metabolism of
                 P32-labeled Bayer L 13/59 in a cow.  Journal of Economic En-
                 tomology 49(6):801-806.  (Also In unpublished submission re-
                 ceived Aug 18, 1966 under 7F0612; submitted as report number
                 1635 by Chemagro Corp., Kansas City, Mo.; CDL:090796-V)

00005300      Metcalf, R.L.; Fukuto, T.R.;  March, R.B. (1959) Toxic action of
                 dipterex and DDVP to the house fly.  Journal of Economic En-
                 tomology 52(l):44-49.  (Also In unpublished submission re-
                 ceived Aug 18, 1966 under 7F0612; submitted as report number
                 2217 by Chemagro Corp., Kansas City, Mo.; CDL:090796-Y)

00005494      MacDougall, D. (1962) Acute Toxicity of Some Organophosphorous In-
                 secticides to Rats.  (Unpublished study including letter dated
                 Nov 23, 1962 from D. MacDougall to Dr. Jasper, received Nov 26,
                 1962 under unknown admin,  no.; prepared by Chemagro Corp., sub-
                 mitted by Bayvet, Shawnee Mission, Kans.; CDL:109105-A)

00028625      Simmon, V.F. (1979) In vitro Microbiological Mutagenicity and Un-
                 scheduled DNA Synthesis Studies of Eighteen Pesticides: Report
                 No. EPA-600/1-79-041.  (Unpublished study including submitter
                 summary, received Apr 3, 1980 under 279-2712; prepared by SRI
                 International, submitted by FMC Corp., Philadelphia, Pa.; CDL:
                 099350-A)

00034769  ,    Hill, E.F.; Heath, R.G.; Spann, J.W.; et al. (1975) Lethal Dietary
                 Toxicities of Environmental Pollutants to Birds.  By U.S. Fish
                 and Wildlife Service, Patuxent Wildlife Research Center.  Wash-
                 ington, D.C.: U.S. FWS.  (Special Scientific Report—Wildlife
                 No. 191; also In unpublished submission received Mar 28, 1979
                 under 3125-236; submitted as report number 33423a by Mobay
                 Chemical Corp., Kansas City, Mo.; CDL:237905-B)
                                                       ;    -V.rfv  ' '•
00036935      Atkins, E.L.; Greywood, E.A.; Macdonald, R.L. (1975) Toxicity of
                 Pesticides and Other Agricultural Chemicals to Honey Bees: Labo-
                 ratory Studies.  By University of California, Dept. of Entomolo-
                 gy.  (UC/Cooperative Extension Leaflet 2287; published study.)
                                     127

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                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
               Registration Under the Trichlorfon Standard
00060628
00063192
00065495
00068214
00073683
00081186
00091766
Johansen, C.A.; Eves, J. (1965) Bee Poisoning Investigations, 1965:
   Report No. G-1705; Report No. 17338.  (Unpublished study, in-
   cluding letter dated Jun 12, 1973 from C.A. Johansen to A.D. Co-
   hick, received Mar 27, 1974 under 4F1485; prepared by Washington
   State Univ., Dept. of Entomology, submitted by Chemagro Corp.,
   Kansas City, MO.; CDL:092011-1)

Staples, R.E.; Kellam, R.G; Baseman, J.K. (1976) Developmental
   toxicity in the rat after ingestion of gavage of organophosphate
   pesticides (Dipterex, Imidan) during pregnancy.  Environmental
   Health Perspectives 13(Feb):133-140.  (Also In unpublished
   submission received Apr 18, 1978 under 476-1917; submitted by
   Stauffer Chemical Co., Richmond, Calif.; CDL:234110-D)

Pickering, Q.H.; Henderson, C.; Lemke, A.E. (1960) The Toxicity
   of Organic Phosphorus Insecticides to Different Species of
   Warm Water Fishes.  (U.S. Public Health Service, R.A. Taft
   Sanitary Engineering Center, unpublished study including sub-
   mitter summary, received Apr 7, 1977 under 3125-183; submitted
   as report number 9282 by Mobay Chemical Corp., Kansas City, Mo.;
   CDL:229299-A)

Thornton, J.S.; Hurley, J.B.; Obrist, J.J. (1976) Soil Thin-layer
   Mobility of Twenty Four Pesticide Chemicals.  (Unpublished
   study received Jul 11, 1977 under 3125-315; submited as report
   number 51016 by Mobay Chemical Corp., Kansas City, Mo.;
   CDL:230908-1)

Schafer, E.W. (1972) The Acute Oral Toxicity of 369 Pesticidal,
   Pharmaceutical and Other Chemicals to Wild Birds.  (Toxicology
   and Applied Pharmacology 21:315,316,319.  Incomplete; also in
   unlisted sutmission received Mar 21, 1977 under 352-338; sub-
   mitted by E.I. du Pont de Nemours & Co., Wilmington, Del.;
   CDL.-228727-AI)

DuBois, K.P.; Cotter, G.J. (1955) Studies on the toxicity and mech-
   anism of action of dipterex.  American Medical Association
   Archives of Industrial Health 11(Jan):53-60.  (Also in unpublished
   submission received Feb 13, 1961 under 3125-77; submitted as re-
   port number 467 by Mobay Chemical Corp., Kansas City, Mo.; CDL:
   100895-B)
Lamb, D.W.; Roney, D.J. (1972) Acute Toxicity of Dylox (R) Tech-
   nical and Dylox 80% SPA-oil to Fish. -.(Unpublished study received
   Sep 1, 1972 under 3125-278; submitted as report number 32807 by
   Mobay Chemical Corp., Kansas City,  Mo.; CDL:050510-B)
                                     128

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                           OFFICE OF PESTICIDE PROGRAMS
                        REGISTRATION STANDARD BIBLIOGRAPHY
           Citations Considered to be Part of the Data Base Supporting
                   Registration Under the Trichlorfon Standard
00091787      Metcalf, R.L.; Winton, M.Y.; Fukuto, T.R. (1958) Dipterex Residues
                 on Citrus and Alfalfa as Studied by P 32-labeled Compound.
                 (Unpublished study received Aug 18, 1966 under 3125-49; prepared
                 by Univ. of California—Riverside, Dept.  of Entomology, Citrus
                 Experiment Station; submitted as report number 2333 by Mobay
                 Chemical Corp., Kansas City, Mo.; CDL:090790-C)

00091852      Olson, T.J. (1968) A Study of DDVP Formation Resulting from Tri-
                 chlorfon Treatment of Alkaline Pond Water.  (Unpublished study
                 received Sep 19, 1969 under 3125-143; submitted as report number
                 21808 by Mobay Chemical Corp., Kansas City, Mo.; CDL:102088-C)

00091881      Henderson, C.; Pickering, Q.H.; Tarzwell, C.M. (1959) The Toxicity
                 of Organic Phosphorus and Chlorinated Hydrocarbon Insecticides
                 to Fish: Mobay 4276a.  (U.S. Public Health Service, Robert A.
                 Taft Sanitary Engineering Center, Water Supply and Water Pollu-
                 tion Research, Bioassay Application Studies; unpublished paper
                 presented at the Second Seminar on Biological Problems in Water
                 Pollution; Apr 21, 1959; Cincinnati, Ohio.  Unpublished study
                 received Mar 4, 1966 under unknown administrative number; sub-
                 mitted as report number 4276 by Mobay Chemical Corp., Kansas
                 City, Mo.; CDL:110547-B)

00092002      Grimble, D.G.; Sykes, R.B., Jr.; Devine, J.M.; et al. (1972) An
                 Evaluation of the Environmental Impact and Efficacy of an Aerial
                 Application of Trichlorfon (Dylox) against the Gypsy Moth and
                 Associated Organisms in New York State.  (Unpublished study re-
                 ceived May 20, 1977 under 3125-210; prepared by State Univ. of
                 New York—Syracuse, Applied Forestry Research Institute, submit-
                 ted as report number 32702 by Mobay Chemical Corp., Kansas
                 City, Mo.; CDL:230752-T)

05000837     Johansen, C.A. (1972) Toxicity of field-weathered insecticide
                 residues to four kinds of bees.  Environmental Entomology
                 1(3):393-384

05004412      Palmer-Jones, T.; Forster, I.W. (1963) Effect on honey bees of
                 Dipteres, Thiodan, and Phosdrin applied as sprays to white
                 clover (Trifolium repens),  New Zealand Journal of
                 Agricultural Research 6(3/4):303-306
                                     129

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
GS0104001   Thornton, J.S. (1967) Determination of residues of
            Trichlorfon in cottonseed by thermionic emission gas
            chromatography, Report no. 21386; (Unpublished study received
            Oct 16, 1975 under PP#6F1688; submitted by Boychem Corp.;
            Chemagro Div.)

GS0104002   Obrist, J.S. (1975) An interference study for the residue
            method for Trichlorfon on soybeans, Report no. 44408;
            (Unpublished study received Oct 16, 1975 under PP#6F1688,
            submitted by Mobay Chemical Corp, Chemagro Agricultural Div.)

4S0104003   Chemagro Agricultural Division (1975) Mobay Chemical Corporation
            residue experiment.  Report nos. 44411-44429; (Unpublished
            study received Oct 16, 1975 under PP#6F1688, prepared by Lake
            Ontario Environmental Laboratories).

GS0104004   Chemagro Corp. (1967) Chemagro residue experiment no. KC-505-
            67D, Study no. 21502; (Unpublished study received Oct 16,
            1975 under PP#6F1688)

GS0104005   Chemagro Corp. (1962) Dylox analytical, residue, and taste
            information (peppers and tomatoes), Report no. 8442 and 9014;
            (Unpublished study received May 15, 1967 under PP#7F0612)
            CDL:RCB 115100.

GS0104006   Chemagro Corp. (1963) Dylox analytical and residue data
            (barley, flax, oats, and wheat), Report no. 10081; (Unpublished
            study received May 15, 1967 under PP#7F0612) CDL:RCB 115101.

GS0104007   Chemagro Corp. (1975) Dylox analytical and residue data
            (cowpeas and lima beans), Report no. 14553; (Unpublished
            study received May 15, 1967 under PP#7F0612) CDLiRCB 115102.

GS0104008   Chemagro Corp. (1966) Trichlorfon analytical and residue
            information (corn), Report no. 11560; (Unpublished study
            received May 15, 1967 under PP#7F0612) CDL:RCB 115107.

GS0104009   Chemagro Corp. (1962) Dylox residue data, (table beets), Report
            nos. 9216, 9217, 9218, 9219, 9220, 9522, 9524 and 9528;
            (Unpublished study received Aug 30, 1967 under PP#7F0612)
            CDL:RCB 115089.

GS0104010   Chemagro Corp. (1962) Dylox residue data (carrots), Report
            nos. 8891,8898, 8898, 8901 and 9523; (Unpublished study
            received Aug 30, 1967 under PP#7F0612) CDLrRCB 115089.
                                      130

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
GS0104011   Chemagro Corp. (1962) Dylox residue data (head and leaf
            lettuce), Reports nos. 8555, 8558, 8560, 8562, 8564, 8974 and
            9521; (Unpublished study received Aug 30, 1967 under PP#7F0612)
            CDL:RCB 115089.

GS0104012   Chemagro Corp. (1962) Dylox analytical, residue, and taste data,
            green beans, cauliflower, and kale, Report no. 8996; (Unpublished
            study received May 15, 1967 under PP#7F0612) CDL:RCB 115093.

GS0104013   Chemagro Corp. (1967) Trichlorfon analytical and residue
            information for forage crops, cowpeas, and lima beans, Report
            nos. 14957, 14958 and 14973; (Unpublished study received May
            15, 1967 under PP#7F0612) CDL:RCB 115094 and 115102.

GS0104014   Chemagro Corp. (1967) Trichlorfon analytical and residue
            information for forage crops, cowpeas, and lima beans, Report
            nos. 14885, 14889, 14947 and 14968; (Unpublished study received
            May 15, 1967 under PP#7F0612) CDL:RCB 115094 and 115102.

GS0104015   Chemagro Corp. (1962) Dylox analytical, residue and taste
            data, green beans, cauliflower, and kale, Report nos. 8894,
            8896, 8897 and 8902; (Unpublished study received May 15, 1967
            under PP#7F0612) CDLrRCB 115093.

GS0104016   Chemagro Corp. (1962) Dylox analytical, residue and taste
            information (peppers and tomatoes), Report nos. 9003 and
            8460-8471; (Unpublished study received May 15, 1967 under
            PP#7F0612) CDL:RCB 115100.

GS0104017   Chemagro Corp. (1962) Dylox analytical, residue and taste
            information (peppers and tonatoes), Report nos. 8472-8481;
            (Unpublished study received May 15, 1967 under PP#7F0612)
            CDL:RCB 115100.

GS0104018   Chemagro Corp. (1965) Dylox analytical and residue data
            (pumpkin), Report nos. 14770, 14939, 14942, 14951-14956 and
            14959-14964; (Unpublished study received May 15, 1967 under
            PPI7F0612) CDL:RCB 115091.

GS0104019   Chemagro Corp. (1963) Dylox analytical and residue data
            (barley, flax, oats and wheat). Report nos. 11538, 11544,
            11545, 11561 and 12034; (Unpublished study received May 15,
            1967 under PP#7F0612) CDL:RCB 115101.

GS0104020   Chemagro Corp. (1966) Trichlorfon analytical and residue
            information (corn) Report nos. 17461 and 17483-17494;
            (Unpublished study received May 15, 1967 under PPI7F0612)
            CDL:RCB 115107.
                                      131

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                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
GS0104021   Chemagro Corp.  (1963) Dylox analytical and residue data
            (barley, flax, oats, and wheat); Report nos. 11541, 11542,
            11546, 11547 and 11561; (Unpublished study received May 15,
            1967 under PP#7F0612) CDLrRCB 115101.

GS0104022   Chemagro Corp.  (1963) Dylox analytical and residue data
            (barley, flax, oats and wheat), Report nos. 11543, 11549, and
            11561; (Unpublished study received May 15, 1967 under PP#7F0612)
            CDL:RCB 115101.

GS0104023   Chemagro Corp.  (1967) Trichlorfon analytical and residue
            information for forage crops, cowpeas, and lima beans, Report
            nos. 18836, 17757, 18833 and 18832; (Unpublished study received
            May 15, 1967 under PP#7F0612) CDLrRCB 115096 and 115094.

GS0104024   Chemagro Corp.  (1966) Trichlorfon analytical and residue
            information (corn), Report nos. 17461 and 17483-17494;
            (Unpublished study received May 15, 1967 under PP#7F0612)
            CDL:RCB 115107.

GS0104025   Chemagro Corp.  (1967) Trichlorfon analytical and residue
            information for forage crops, cowpeas, and lima beans, Report
            nos. 18834, 18835, 18851 and 17459; (Unpublished study received
            May 15, 1967 under PP#7F0612) CDL:RCB 115094 and 115096.

GS0104026   Chemagro Corp.  (1967) Trichlorfon analytical and residue
            information for forage crops, cowpeas, and lima beans, Report
            nos. 18814, 18815, and 17457; (Unpublished study received May
            15, 1967 under PP#7F0612) CDLrRCB 115094 and 115096.

GS0104027   Chemagro Corp.  (1967) Trichlorfon analytical and residue
            information for forage crops, cowpeas and lima beans, Report
            nos. 8973, 8976, 8978, 8997, 8998, 17460, 18816, 18818, 18820,
            18831 and 18830; (Unpublished study received May 15, 1967
            under PP#7F0612) CDLrRCB 115094 and 115096.

GS0104028   Chemagro Corp. (1967) Trichlorfon analytical and residue
            information for forage crops, cowpeas, and lima beans, Report
            nos. 8954-8956, 8958, 18812, 18817, 18821-18826 and 17876;
            (Unpublished study received May 15, 1967 under PP#7F0612)
            CDLrRCB 115094 and 115096.

GS0104029   Chemagro Corp. (1962) Dylox analytical and residue data
            (bananas), Report nos. 20413, 20414, 20424, 20425, 20426 and
            20427 (Unpublished study received May 15, 1967 under PP#7F0612)
            CDLrRCB 115106.

GS0104030   Chemagro Corp. (1963) Dylox analytical and residue data
            (barley, flax, oats, and wheat), Report nos. 11540, 11539,
            11561 and 12034 (Unpublished study received May 15, 1967
            under PP#7F0612) CDLrRCB 115101.
                                      132

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
GS0104031   Chemagro Corp. (1962) Dylox residue data (safflower), Report
            nos. 11219, 11220, and 11221 (Unpublished study received Aug.
            30, 1967 under PP# Section D of 7F0612) CDL:RCB 115089.

GS0104032   Chemagro Corp. (1963) Neguvon Residue information on cattle
            tissues (spray), Report nos. 10325, 10411, 10412, 10413, and
            12843 (Unpublished study received May 15, 1967 under PP#7F0612)
            CDL:RCB 115092.

GS0104033   Chemagro Corp. (1967) Trichlorfon analytical and residue
            information for forage crops, cowpeas, and lima beans, Report
            no. 17991 (Unpublished study received May 15, 1967 under
            PP#7F0612) CDL:RCB 115094.

GS0104034   Chemagro Corp. (1967) Trichlorfon analytical and residue
            information for forage crops, cowpeas, and lima beans, Report
            no. 18884 (Unpublished study received May 15, 1967 under
            PP#7F0612) CDL:RCB 115096.

GS0104035   Chemagro Corp. (1966) Co-Rol-Trichlorfon analytical and
            residue information on mist spray application to dairy and
            beef cattle, Report No. 18495 (Unpublished study received
            May 15, 1967 under PPI7F0612) CDL:RCB 115097.

GS0104036   Chemagro Corp. (1964) Neguvon analytical and residue
            information on backline application, Report #14412 (Unpub-
            lished study received May 15, 1967 under PP#7F0612) CDL:RCB
            115103.

GS0104037   Chemagro Corp. (1963) Neguvon residue information on
            cattle tissues (spray), Report #18322 (Unpublished study
            received May 15, 1967 under PP#7F0612) CDLiRCB 115092.

GS0104038   Chemagro Corp. (1967) Trichlorfon analytical and residue
            information for forage crops, cowpeas, and lima beans, Report
            nos. 17440, 17970, 18321 and 21289; (Unpublished study received
            May 15, 1967 under PP#7F0612) CDL:RCB 115094.

GS0104039   Chemagro Corp. (1962) Dylox (Dipaterex) on bananas, Report
            nos. 8839 and 8806; (Unpublished study received Nov. 26, 1962
            under PP#0384) CDL:RCB 114214 and 114215.

GS0104040   Chemagro Corp. (1962) Dylox (Dipterex) on bananas, Report
            nos. 9121, 9122, 9123, 9124 and 9132; (Unpublished study
            received Nov 26, 1962 under PP#0384) CDL:RCB 114214 and
            114215.

GS0104041   Chemagro Corp. (1971) Trichlorfon analytical and residue
            information on forage crops, Report no. 14770; (Unpublished
            study received Aug 17, 1971 under PP#2F1177) CDL:RCB 117411.
                                     133

-------
                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard


GS0104053   Chemagro Corp. (1971) Trichlorfon analytical and residue
            information on forage crops, Report nos. 29109, 29111, 29209,
            and 29308; (Unpublished study received Aug 17, 1971 under
            PP#2F1177) CDLrRCB 117416.

GS0104054   Chemagro Corp. (1971) Trichlorfon analytical and residue
            information on forage crops, Report nos. 20997 and 21040;
            (Unpublished study received Aug 17, 1971 under PP#2F1177)
            CDLrRCB 117411.

GS0104055   Chemagro Corp. (1971) Trichlorfon analytical and residue
            information on forage crops, Report no. 29234; (Unpublished
            study received Aug 17, 1971 under PP#2F1177) CDL:RCB 117416.

GS0104056   Chemagro Corp. (1970) Trichlorfon analytical and residue
            information on peanuts, Report nos. 14393 and 16460; (Unpublished
            study received April 27, 1970 under PP#OF0969) CDLrRCB 11614.

GS0104057   Chemagro Corp. (1970) Trichlorfon analytical and residue
            information on peanuts, Report nos. 21809 and 24808; (Unpublished
            study received April 27, 1970 under PP#OF0969) CDL:RCB 116615.

GS0104058   Chemagro Corp. (1970) Trichlorfon analytical and residue
            information on peanuts, Report nos. 25241, 25242, 25278-25284,
            25300-25303,  and 25306; (Unpublished study received April 27,
            1970 under PP#OF0969) CDL:RCB 116615.

GS0104059   Chemagro Corp. (1972) Trichlorfon analytical and residue
            information on citrus fruit, Report no. 29411; (Unpublished
            study received March 1, 1972 under PP#2F1242) CDLrRCB 117736.

GS0104060   Chemagro Corp. (1972) Trichlorfon analytical and residue
            information citrus fruit, Report nos. 21811, 26334, and 27471;
            (Unpublished study received March 1, 1972 under PP#2F1242)
            CDL:RCB 117733.

GS0104061   Chemagro Corp. (1972) Trichlorfon analytical and residue
            information on citrus fruit, Report no. 11908; (Unpublished
            study received March 1, 1972 under PP#2F1242) CDLrRCB 117733.

GS0104062   Chemagro Corp. (1972) Trichlorfon analytical and residue
            information on lima beans, Report nos. 29213-292215, 29222,
            29227, 29322, 29323, and 31455-31459; (Unpublished study
            received March 1, 1972 under PP#2F1242) CDL:RCB 117737.

GS0104063   Chemagro Corp. (1972) Trichlorfon analytical and residue
            information on lima beans, Report nos. 29213-29215, 29222,
            29227, 29322, 29323, and 31625-31631; (Unpublished study
            received March 1, 1972 under PP#2F1242) CDL:RCB 117737.
                                     134

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                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
GS0104064   Chemagro Corp. (1972) Trichlorfon analytical and residue
            information on citrus fruit, Report nos. 29744, 31326, 31472,
            31644, 31930, 29728-29735, 30931, 29211, 29212, 29719 and
            29720; (Unpublished study received March 1, 1972 under PP#2F1242)
            CDL:RCB 117733 and 117736.

GS0104065   Chemagro Corp. (1972) Trichlorfon analytical and residue
            information on citrus fruit, Report No. 29226; (Unpublished
            study received March 1, 1972 under PP#2F1242) CDL:RCB 117736.
GS0104066
GS0104067
GS0104068
GS0104069
GS0104070


GS0104071



GS0104072



GS0104073



GS0104074
Chemagro Corp. (1972) Trichlorfon analytical residue information
on citrus fruit, Report no. 29226; (Unpublished study received
March 1, 1972 under PP#2F1242) CDLrRCB 117736.

IR-4 Project (1982) Petition proposing a tolerance for
trichlorfon for use in lowbush blackberry productions, Test nos. 28435,
44241-44246, 45222 and 45223 in Section D; (Unpublished study received
Feb 19, 1982 under PP#2E2646) CDL:RCB 070686.

IR-4 Project (1977) Petition proposing tolerance for trichlorfon
in or on birdsfood trefoil (PR#6021/Seed Crop/Section D; (Unpublished
study received Sept 27, 1977 under PPI7E2008)

Gaines, T.B. 1960.  The acute toxicity of pesticides to rats.
Toxicology and Applied Pharmacology 2:88-99.  (Also In
unpublished study received August 18, 1966 under 7F0612;
submitted by ?; CDL:090786).

Gaines, T.B. 1969.  The acute toxicity of pesticides.  Toxicol.
Appl. Pharmacol.  14:515-534.

US-EPA. 1961. "Neguvon.  Pharmacology and Toxicology Data.
February 2, 1961."  Submitted in support of Petition 7F0612
(EPA Accession #090786.

Edson, E.F. and Noakes, D.N. 1960.  The comparative toxicity
of six organophosphorus insecticides in the rat.  Toxicol.
Appl. Pharmacol. 2:523-539.

Olajos, E.G., Rosenblum, I., Coulston, F., S. Stromiger, N.
1979.  The dose-response relationship of trichlorfon
neurotoxicity in hens.  Ecotox. Environ. Safety 3:245-255.

Machemer, L. 1979.  Mobay Report No. 69299:  "L13/59
(Trichlorfon).  Evaluation for Efrbryotoxic and Teratogenic
Effects on Orally Dosed Rabbits,' by Dr. L. Machemer, Bayer
AG Institute fur Toxikologie, (Report No. 8430, June 8, 1979).
Ace. No. 244915.
                                     135

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                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
                     Registration Under the Standard
GS0104075   Staples R.E., Goulding, E.H.  1979.  Dipterex teratogenicity
            in the rat, hamster, and mouse when given by gavage.
            Environmental Health Perspectives, 30:105-113.

GS0104076   Loesser, E.  1969:  "Bay 15 922.  Generation Study of Rats,"
            by Dr. E. Loser, Farbenfabriken Bayer AG Institut fur
            Toxikologie, Wupperfal-Elberfeld (Report No. 1195, January
            23, 1969).  Ace. No. 244915 (Mobay Report no. 25855, March
            24, 1981).

GS0104077   Shirasu, Y., Moriya, M. and Koyashiki, R. 1983.  Mobay Report
            No. 69367:  "Trichlorfon.  Mutagenicity Test on Bacterial Systems,"
            Institute of Environmental Toxicology (Japan), October 30,
            1979.  Ace. No. 249535.

GS0104078   SRI (1980a)  An Evaluation of the Effect of Trichlorphon on
            Sister Chrcmatid Exchange frequencies in cultured Chinese
            hamster ovary cells.  Prepared for:  Environmental Protection
            Agency, Research Triangle Park, North Carolina 27711.  SRI
            Project LSU-7558.

GS0104079   SRI (1980c)  In Vitro Detection of Mitotic Crossing-Over,
            Mitotic Gene Conversation, and Reverse Mutation with S.
            Cerevisiae D7 for Seven Pesticides.  EPA Contracts Management
            Division (MD-33), Attention:  NCCM-6, Research Triangle Park,
            North Carolina 27711.  Contract No. 68-02-2947, SRI Project
            LSU-7558-20.

GS0104080  Chemagro Corp. (1977) Aerobic soil metabolism study, Report
           no. 32365; Ace. No. 230752.

GS0104081  Johnson, W., and Finley, M., (1980) Handbook of acute toxicity
           of chemicals to fish and wildlife invertebrates.  U.S. Fish
           and Wildlife Service Pub. No. 137.  Washington, D.C.
                                      136

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                                                          TT-3.
                    FIFKA SECTION 3(C)(2)(B) SUMMARY SHEET
                                                                                             EPA
  PRODUCT NAME
  APPLICANT'S NAME
                                   DATE GUIDANCE DOCUMENT ISSUED
    With respect to the requirement to tubmit "aer»eric"diti imposed by the FIFRA section 3(C)12)(B) notice contained in the referenced
    Guidance Document. I am responding in the following manner:
       01.  I will submit data in • timely manner to satisfy the following requirement!. I! the ten procedures I will UK deviate from (or are not
             specified in) the Rep'mnrtion Guidelines or the Protocols contained in the Reports of Expert Groups to the Chemicals Group. OE CD
          K- Chemicals Testing Programme, I enclose the protocols that I will us:                              . *
      O 2.  I have entered into an agreement with one or more other registrants under FIFRA section 3(C)l2)(B)(ii) to satisfy the following dau
             requirements. The testi, and any required protocols, will be submitted to EPA fay:

   NAME OF OTHER REGISTRANT                                                                                	
      O 3. I enclose a completed "Certification of Attempt to Enter Into an Agreement with Other Registrants for Development of Date" with
            respect to the following data requirement!:
      O 4.  I request that you amend my registration by deleting the following uses (this option is not available to applicants for new products):
     O 5.  I request voluntary cancellation of the registration of this product. (This option is not available to applicants for new products.)
REGISTRANT'S AUTHORIZED REPRESENTATIVE
SIGNATURE
                                                                                                                DATE
EPA Form 8580-1 (10-62)
                                                                  137

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                                                     Appendix  11-3
                                                                                OMB
CERTIFICATION OF ATTEMPT TO ENTER
INTO AN AGREEMENT WITH OTHER REGISTRANTS
(To 9t»l/fy. emHyALL lour ttmt) *OR DE VE LOfMENT OF DATA
1 . 1 am duly authorized to raprtsent the following firm(s) who »re subject to the require
cfncnts of •Notice under FIFRA Section 8(c)(2)(B) contained in* Guidance Document
" to submit data concerning the active ingredient:
NAME Or FIRM

- •-• ...
• -

GUIDANCE DOCUMENT DATE
ACTIVE INGREDIENT
€f A COMPANY NUMBE R

...
1
•
(This firm or group of firms is referred to below as "my firm".!
  2. My firm b willing to develop and submit the data as required by that Notice, if necessary. However, tny firm would prefer to erne:
    into an agreement with one or more other registrants to develop jointly, or to share in the cost of developing, the following require*
    hems or data:
   My firm has offered in writing to anter into such an agreement Copies ef the off en an anachid.That offer wu irrevocable and included an offer to fc
   *ound fey an arbitration decision under FIFRA Section 3U)l2)|B)liii) if final agreement on all terms could not to reched otherwise  This offer wts mid
   1» tht following firm(s) en the following dated):
*IAME OF FIRM




DATE OF OFFER ''

. • ,'


However, none of those iirmU) eccepteti my offer.
4. My firm requens that EPA not suspend the registration(s) of my firm's product(s), if any of the firms named in paragraph (3) fibtr.
  'have agreed to submit the data lined in paragraph (2) above in accordance with the Notice. I understand EPA will promptly infon
   me whether my  firm must tubmh data to avoid suspension of  its registration(s) under FIFRA Section 3(c)(2)(B). (This staiemei
   does not apply to applicants for new products.) I give EPA permission to disclose this statement upon request.
rrrco NAME
SIGNATURE
                                                                                                         DATE

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                                                    Appendix III-l
                       PRODUCT SPECIFIC DATA REPORT




EPA Registration No.	Guidance Document for




                                                Date
Registration
Guideline No.
§158.20
PRODUCT
CHEMISTRY
61-1
61-2
61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-10
63-11
63-12
63-13
63-14
63-15
63-16
63-17
63-18
63-19
Name of Test

Identity of
ingredients
Statement of
composition
Discussion of
formation of
ingredients
Preliminary
analysis
Certification of
limits
Analytical methods
for enforcement
limits
Color
Physical state
Odor
Melting point
Boiling point
Density, bulk-
density, or
specific gravity
Solubility
Vapor pressure
Dissociation
constant
Octanol/water
partition
coefficient
PH
Stability
Oxidizing/reducing
reaction
Flammability
Explodability
Storage stability
Viscosity
Miscibility
Test not
required
for my
product
listed
above
( check
below)

























I am complying with
data requirements by
Citing MRID#

























Submit-
ting
Data
(At-
tached)















, ^•".•('









(For EPA Use Only)
Accession Numbers
Assigned

























                                      139

-------
                                                     Appendix III-l  (Continued)
                       PRODUCT SPECIFIC DATA REPORT



EPA Registration No.	Guidance Document for_



                                                 Date
63-20
63-21
§158.135
TOXICOLOGY
81-1
81-2
81-3
81-4
81-5
81-6
Corrosion
characteristics
Dielectric break-
down voltage

Acute oral LD-50,
rat
Acute dermal
LD-50
Acute inhalation,
LC-50 rat
Primary eye
irritation, rabbit
Primary dermal
irritation
Dermal sensitiza-
tion




































                                     140

-------
PflECAUTONAAV STATEMENTS

  HOARDS TO HUMANS

  (t DOMESTIC ANIMALS)

      OANQER
 ENVftONMENTAL HAZARDS
 PHY8CAL (M CHCMCAL

    HAZARDS
n* iMMai •* MB* IM
     *• • www MB
  W-€MtWV STATfMtNT
  STORAGE AND

    DISPOSAL
      RESTRICTED USE

           PESTICIDE
for retifl tile to tnd ott only by CtrtlMH Ap
or pcnoni tinder th«1r tftrtet tuptrvldon md only for
thoif OKI covered by th* Certified Hppllctton Certifi-
cation.                   	
       PRODUCT
           NAME
                            ACTWE MOREDCNT:

                            tIERT MOREOCNTS.


                            TOTAL:
                                                 10000*
                            TH8 PRODUCT CONTAM3  IBS Of  ft* GALLON
                           KEEP OUT OF REACH OF CHILDREN

                              DANGER
       STATtMCNT OF PflACTBAL TREATMCNT
                        rsw ALLOW

                        r MHAUD:

                        rONBKN:

                        r M ETCS :
                        SEC am PANEL row
                                                   STATEMCNTS
                        MFOBv:

                        TOWN. STATE:
                      SPESTARLBHMENT NO
                        EPA nEOtSTHATtON NO.
                                  NET CONTENTS:
                                                                  CROP:
                                                                  CHOP:
                                                                  CHOP:
                                          CHOP:
                                                                    WARRANTY STATEMENT
                                                                     •a
                                                                     X)

                                                                     §
                                                                     Ou
                                                                      VH

                                                                      <

                                                                      I

-------
to
             !
           !•
                  HA;Anus to HUMANS
                  II OUMISIC
                 ENVinONMCNf Al HA/Anns
                     MA7AROS
                  omictoNS ron use
               CfNflAt ClASSlflCAflOH
               i h • «MMon « FMirtf k» to
               M  pwdtict n • nmrar
                  nc INIHV
                    I*
                  STORAGE AND
                    DISPOSAL
                OISPOSAI
               CHOP
         PRODUCT
           NAME
                                             AC I'VE
     tQIAl
                                             (MIS rnoouci CONTAINS   IDS of
                          10000%
                                            KEEP OUT OF REACH OF Cf IILDREN
                                                 CAUTION
        SIATCMENT OF PRACICAl
* SWAIIOWEO:
* MHAICO =
r ON SKH	
V NIYtS =
                                         SEE SCf PANfl ron AODfTONAl rnECAUUCVMRT SIA1EMEIITS
                                        MfQ BY
                                     y~M 'OWN
                                        CSrABllSMMENf NO
                                        EPA I
                                                   Nil CONlEHIS:
                                                                             to
                                                                                    CROP
                                                                                    cnor
                                           CHOP'
                                                                                      WAnnANrVStAtCMENI

-------
                                                                                        APPENDIX rv-2
LABELING REQUIREMENTS OF THE FIFRA, AS AMENDED (REFER TO THE SAMPLE LABELS FOLLOWING)

ITEM
1
2
3
4
5
6A
6B
7
7A
7B

LA?EL ELEMENT
Product name
Company name
and address
Net contents
EPA Est. No.
EPA Reg. No.
\
Ingredients
statement
'?.
Pounds/gallon
statement
*• • i
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where, dosage
giverfas Ibs.
ai/unit area
All products
All products
All products
PLACEMENT
REQUIRED
Front panel
None
None
None
None
Front panel
Front panel
Front panel
Front panel
Front panel
ON LABEL
PREFERRED
Center front
panel
Bottom front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel,
immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the main
ingredients
statement

Above signal
word
Immediately
below child
hazard
warning

COMMENTS

If registrant is not the producer, mupt-
be qualified by "Packed for . . .,"
"Distributed by. . .," etc.
May be in metric units in addition to
U.S. units
Must be in similar type si7e and run
^parallel to other type.
May appear on the container instead of
the label.
Text must run parallel with other tevt-
on the panel.

All front panel precautionary Ptateinont-p
must be grouped together, preferably
blocked.
Note type size requirement- P.
Note type size requirement P.

-------
                                    APPKNDIX TV-2  (CTPP tinnerl)

ITEM
7C
7D


7E
8
8A
8B

LABEL ELEMENT
Skull & cross-
bones and word
POISON (in red)
Statement of
practical
treatment

Referral
statement
Side/back panel
precautionary
statements
Hazards to
humans and
domestic
animals
Environmental
hazards
APPLICABILITY
OF REQUIREMENT
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxicity
All products
in Categories
I, II, and III

All products
where pre-
cautionary
labeling
appears on
other than
front jpanel.
All products
All products
in Categories
I, II, and III
All products
PLACEMENT
REQUIRED
Front panel
Category I:
Front panel
unless refer-
ral statement
is used.
Others:
Grouped with
side panel
precautionary
statements.
Front panel
None
None
None
ON LABEL
PREFERRED
Both in close
proximity to
signal word
Front panel
for all.


Top or side
of back panel
preceding
directions
for use
Same as above
Same as above

COMMENTS





Must be grouped under the headings in
8A, 8B, and 8C? preferably blocked.
Must be preceded by appropriate signal
word.
Environmental hazards include bee
caution where applicable.
1 A A

-------
APPENDIX W-2

ITEM
8C
9A
9C
10A
IOC
10D
U.S.

LABEL ELEMENT
Physical or
chemical
hazards
Restricted
block
Misuse
statement
Re-entry
statement
,
-------
                                                   Appendix IV-3
                    PHYSICAL-CHEMICAL HAZARDS
Criteria
I.  Pressurized Containers

    A.  Flashpoint at or below
        20°F; or if there is a
        flashback at any valve
        opening.
    B.  Flashpoint above 20°F
        and not over 80°F;  or
        if the flame extension
        is more than 18 inches
        long at a distance of
        6 inches from the
        valve opening.

    C.  ALL OTHER PRESSURIZED
        CONTAINERS
II.  Non-Pressurized Containers

    A.  Flashpoint at or below
        20°F.
    B.  Flashpoint above 20°F
        and over 80°F.

    C.  Flashpoint over 80°F
        and not over 150°F.

    D.  Flashpoint above
        150°F.
Required Label Statement
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces.  Do not
puncture or incinerate
container.  Exposure to
temperatures above 130°F
may cause bursting.

Flammable.  Contents under
pressure.  Keep away from
heat, sparks, and flame.  Do
not puncture or incinerate
container.  Exposure to
temperatures above 130°F
may cause bursting.

Contents under pressure.
Do not use or store near
heat or open flame.  Do not
puncture or incinerate
container.  Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable.  Keep
away from fire, sparks, and
heated surfaces.

Flammable.  Keep away from
heat and open flame.

Do not use or store near
heat and open flame.

None required.
                                146

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                                               Appendix IV-5

       STORAGE AND DISPOSAL INSTRUCTIONS FOR PESTICIDES

All products are required to bear specific label instructions
about storage and disposal.  Storage and disposal instructions
must be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL.  Products
intended solely for domestic use need not include the heading
"STORAGE AND DISPOSAL."  The STORAGE AND DISPOSAL heading
must appear in the minimum type size listed below:
1                                 |Required type size    |
(Size of label                   |    for the heading       j
(front panel in                  j    STORAGE AND DISPOSAL  |
 square inches	|   (all capitals)	
 10 and under	6 point
 Above 10 to 15	8 point
 Above 15 to 30	10 point
 Over 30	12 point
Storage and disposal instructions must be set apart and
clearly distinguishable from other directions for use.
Blocking storage and disposal statements with a solid line is
suggested as a means of increasing their prominence.

A.  Storage Instructions;

All product labels are required to have appropriate storage
instructions.  Specific storage instructions are not prescribed,
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors:

1.  Conditions of storage that might alter the composition or
    usefulness of the pesticide.  Examples could be temperature
    extremes, excessive moisture or humidity, Jjeat, sunlight,
    friction, or contaminating substances or media.

2.  Physical requirements of storage which might adversely
    affect the container of the product and its ability to
    continue to function properly.  Requirements might include
    positioning of the container in storage, storage or damage
    due to stacking, penetration of moisture, and ability to
    withstand shock or friction.

3.  Specifications for handling the pesticide container,
    including movement of container within the storage area,
    proper opening and closing procedures (particularly for
    opened containers), and measures to minimize exposure
    while opening or closing container.
                                147

-------
                                                 Appendix IV-5
                                                 (continued)

4.  Instructions on what to do if the container is damaged in
    any way, or if the pesticide is leaking or has been
    spilled, and precautions to minimize exposure if damage occurs.

5.  General precautions concerning locked storage, storage in
    original container only, and separation of pesticides
    during storage to prevent cross-contamination of other
    pesticides, fertilizer, food, and feed.

6.  General storage instructions for household products should
    emphasize storage in original container and placement in
    locked storage areas.

B.  Pesticide Disposal Instructions;

The label of all products, except those intended solely for
domestic use, must bear explicit instructions about pesticide
disposal.  The statements listed below contain the exact wording
that must appear on the label of these products:

1.  The labels of all products, except domestic use, must
    contain the statement, "Do not contaminate water, food,
    or feed by storage or disposal."

2.  Except those products intended solely for domestic use,
    the labels of all products that contain active ingredients
    appearing on the "Acutely Hazardous" Commercial Pesticide
    Products List (RCRA "E" List) at the end of this appendix
    or are assigned to Toxicity Category I on the basis of
    oral or dermal toxicity, skin or eye irritation potential,
    or Toxicity Category I or II on the basis of acute inhala-
    tion toxicity must bear the following pesticide disposal
    statement:

    "Pesticide wastes are acutely hazardous.  Improper dis-
    posal of excess pesticide, spray mixture, or rinsate is
    a violation of Federal Law.  If these wastes cannot be
    disposed of by use according to label instructions,
    contact your State Pesticide or Environmental Control
    Agency, or the Hazardous Waste representative at the
    nearest EPA Regional Office for guidance."vt.

    The labels of all products, except those intended for
    domestic use, containing active or inert ingredients
    that appear on the "Toxic" Commercial Pesticide Products
    List (RCRA "F" List) at the end of this appendix or
    presently meet any of the criteria in Subpart C, 40 CFR
    261 for a hazardous waste must bear the following pesticide
    disposal statement:
                                148

-------
                                                 Appendix IV-5
                                                 (continued)

    "Pesticide wastes are toxic.  Improper disposal of excess
    pesticide, spray mixture, or rinsate is a violation of
    Federal Law.  If these wastes cannot be disposed of by
    use according to label instructions, contact your State
    Pesticide or Environmental Control Agency, or the Hazardous
    Waste representative at the nearest EPA Regional Office
    for guidance."

    Labels for all other products, except those intended for
    domestic use, must bear the following pesticide disposal
    statement:

    "Wastes resulting from the use of this product may be
    disposed of on site or at an approved waste disposal
    facility."

3.  Products intended for domestic use only must bear the
    following disposal statement:  "Securely wrap original
    container in several layers of newspaper and discard in
    trash."

C.  Container Disposal Instructions

    The label of each product must bear container disposal
    instructions appropriate to the type of container.

    1.  All products intended for domestic use must bear one
        of the following container disposal statements:
Container Type
                Statement
Non-aerosol products
(bottles, cans, jars)
Non-aerosol products
(bags)
Aerosol products
Do not reuse container (bottle, can, jar).
Rinse thoroughly before discarding in trash.
Do not reuse bag. Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or puncture.
    2.  The labels for all other products must bear container disposal
        instructions, based on container type, listed below:
 Container Type
                 Statement.
 Metal
 containers
 (non-aerosol)
Triple rinse (or equivalent).  Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or by
other procedures approved by state and local
authorities.
 Plastic containers
Triple rinse (or equivalent).  Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or
incineration, or, if allowed by state and
local authorities, by burning.  If burned,
stay out of smoke.	
 Glass containers
Triple rinse (or equivalent).  Then dispose
of in a sanitary landfill or by other
approved state and local procedures.	
                                149

-------
Container Type
                                                Appendix IV-5
                                                (continued)
Statement
Fiber drums
with liners
Paper and
plastic bags
Compressed gas
cylinders
Completely empty liner by shaking and
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reusedl, dispose of in the same manner.
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out of smoke.
Return empty cylinder for reuse (or
similar wording).
    ^Manufacturer may replace this phrase with one indicating whether
    and how fiber drum may be reused.

  2. The labels for all other products must bear container
     disposal instructions, based on container type,  listed
     on the first page of this Appendix.
                               150

-------
                                                 Appendix IV-5
                                                 (continued)
Pesticides that are hazardous wastes under 40 CFR 261.33(e)  and (f)
when discarded.

      "Acutely Hazardous" Commercial Pesticides (RCRA "E" List)
                   Active Ingredients, (no inerts);

Acrolein
Aldicarb
Aldrin
Allyl alcohol
Aluminum phosphide
4-Aminopyridine
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p-Chloroaniline
Cyanides (soluble cyanide salts, not specified elsewere)
Cyanogen chloride
2-Cyclohexyl-4,6-dinitrophenol
Dieldrin
0,0-Diethyl S-[2-ethylthio)ethyl]  phosphorodithioate
      (disulfoton, Di-Syston)
0,0-Diethyl 0-pyrazinyl phosphorothioate (Zinophos)
Dimethoate
0,0-Dimethyl 0-p-nitrophenyl phosphorothioate (methyl parathion)
4,6-Dinitro-o-cresol and salts
4,6-Dinitro-o-cyclohexylphenol
2,4 Dinitrophenol
Dinoseb
Endosulfan
Endothall
Endrin
Famphur
Fluoroacetamide
Heptachlor
Hexanethyl tetraphosphate
Hydrocyanic acid
Hydrogen cyanide
Methomy1
alpha-Naphthylthiourea (ANTU)
Nicotine and salts
Octamethylpyrophosphoramide (OMPA, schradan)
Parathion
                                151

-------
                                                 Appendix IV-5
                                                 (continued)
      "Acutely Hazardous" Commercial Pesticides (RCRA "E" List)
                    Active Ingredients continued;

Phenylmercuric acetate (PMA)
Phorate
Potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
Strychnine and salts
0,0,0,0-Tetraethyl dithiopyrophosphate   (sulfotepp)
Tetraethyl pyrophosphate
Thallium sulfate
Thiofanox
Toxaphene
Warfarin
Zinc phosphide
There are currently no inert ingredients for commercial pesticides
on the "Acutely Hazardous" List (RCRA "E" List).
                                152

-------
                                                 Appendix IV-5
                                                 (continued)
        "Toxic" Commercial Pesticide Products (RCRA "F" List)
                         Active Ingredients;

Acetone
Acrylonitrile
Amitrole
Benzene
Bis(2-ethylhexyl)pthalate
Cacodylic acid
Carbon tetrachloride
Chloral (hydrate)
Chlordane (technical)
Chlorobenzene
4-Chloro-m-cresol
Chloroform
o-Chlorophenol
4-Chloro-o-toluidine hydrochloride
Creosote
Cresylic acid
Cyclohexane
Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[c ,d]-pentalen-2-one
    (kepone, chlordecone)
l,2-Dibromo-3-chloropropane (DBCP)
Dibutyl phthalate
S-3,3-(Dichloroallyl diisopropylthiocarbamate (diallate, Avadex)
o-DiChlorobenzene
p-Dichlorobenzene
Dichlorodifluoromethane (Freon 12®)
3,5-Dichloro-N-(1,l-dimethyl-2-propynyl) benzamide  (pronaroide,Kerb)
Dichloro diphenyl dichloroethane (DDD)
Dichloro diphenyl trichloroethane (DDT)
Dichlorethyl ether
2,4-Dichlorophenoxyacetic, esters and salts  (2,4-D)
1,2-Dichloropropane
1,3-Dichloropropane (Telone)
Dimethyl phthalate
Ethyl acetate
Ethyl 4 ,4'-dichlorobenzilate (chlorobenzilate)
Ethylene dibromide (EDB)
Ethylene dichloride
Ethylene oxide
Formaldehyde
Furfural
Hexachlorobenzene
Hexachlorocyclopentadiene
Hexachloroethane
Hydrofluoric acid
                                 153

-------
                                                 Appendix IV-5
                                                 (continued)
        "Toxic" Commercial Pesticide Products  (RCRA "F" List)
                         Active Ingredients;

Isobutyl alcohol
Lead acetate
Lindane
Maleic hydrazide
Mercury
Methyl alcohol
Methyl bromide
Methyl chloride
2,2'-Methylenebis (3,4,6-trichlorophenol)   (hexachlorophene)
Methylene chloride
Methyl ethyl ketone
4-Methyl-2-pentanone (methyl isobutyl ketone)
Naphthalene
Nitrobenzene
p-Nitrophenol
Pentachloroethane
Pentachloronitrobenzene  (PCNB)
Pentaclorophenol
Phenol
Phosphorodithioic acid, 0,0-diethyl, methyl ester
Propylene dichloride
Pyridine
Resorcinol
Safrole
Selenium disulfide
Silvex
1,2,4,5-Tetrachlorobenzene
1,1,2,2-Tetrachloroethane
Tetrachloroethylene
2 ,3 ,4 ,6-Tetrachlorophenol
Thiram
Toluene
1,1,1-Trichloroethane
Trichloroethylene
Trichloromonofluoromethane  (Freon 11 )
2 ,4,5-Trichlorophenol
2,4,6-Trichlorophenol
2,4,5-Trichlorophenoxyacetic acid  (2,4,5-T)
Xylene
                               154

-------
                                               Appendix IV-5
                                               (continued)
"Toxic" Commercial Pesticide Products (RCRA "F" List)
 Inert Ingredients;
Acetone
Acetonitrile
Acetophenone
Acrylic acid
Aniline
Benzene
Chlorobenzene
Chloroform
Cyclohexane
Cyclohexanone
Dichlorodifluororoethane (Freon ,12®)
Diethyl phthalate
Dimethylamine
Dimethyl phthalate
1,4-Dioxane
Ethylene oxide
Formaldehyde
Formic acid
Isobutyl alcohol
Meleic anhydride
Methyl alcohol (methanol)
Methyl ethyl ketone
Methyl methacrylate
Naphthalene
Saccharin and salts
Thiourea
Toluene
1,1,1-Trichloroethane
1,1,2-Trichloroethane
Trichlorofluoromethane (Freon 11®)
Vinyl chloride
Xylene
                               155

-------
 lutio

    ,.  and Mfety of MM  fonwtttated
    I-UM product, may not consider any
 date  M supporting  MM application.
 except tlM following date:
   (I) The date MM applicant h»» eub-
 nOtted to EPA under paragraph (bV of
 this section;
   (1)  Other  date pertaining  to MM
 Mfety of the product's active Ingredi-
 ents,  rather than to the Mfety of MM
 end UM product; and
   II) Existing tolerance*, food additive
 regulation*,  exemption*,  and other
 dearances  Issued under UM Federal
 Food. Drug, and Cosmetic Ad.         ,
   (e)  If UM applicant knows MM! any
 Item of date he aubmltted under M»to
 •ectlon WM generated by (or at MM •*>
 pense of) another person who original-
 ly aubmltted the date |O BPA (or Its
 predecessor, USD A) on or after Janu-
 ary 1,1910. to support an application
 for  registration,  experimental  UM
 permit, or amendment adding a new
 use to an cabling registration, or for
 rereglstrallon (untoM  Mi*  applicant
 and the original date aubndMW hay*
 reached written  agreement on MM
 amount and MM term* of payment of
 any compensation, thai may bo.pay-
 able     under   , FIFBA   'Motion
. KoKlMDNU) with regard to approval
 of the application). MM applicant chall
 submit to  EPA a atatement Miat bo
 hM fumtohed to each aueh tdenMfted
 original data •ubmlttcn    •   .
   (I)  A notification of th* appttcantV
 Intent to apply for registration. Indutf-
 Ing the proposed produd name;
   fa)  An offer to pay MM penon COM-
 penMUon. with regard to MM approval
 of  th* application, to  MM extent ro- ,
 quired  by  FIFRA •ecMonii McMINp)
 .*nd KeMiKDh
   (I)  An Identification of MM ftonKcl
 of data to which the of far appltos;
   (4)  An offer  to commence negotia-
 tions   to ascertain  MM amount and
 term* of compensation to be paid; and
   (•)  The  applicant'* name, address*
 and telephone number.
   (f>  if the  appllcant'a produd con-
 tains any active Ingredient ether M»sn
 thoM that are  present solely  becauM
 of the Incorporation Into the product,
 dtirlng formulation, of one or  mor*
 other  registered  pesticide  product*
 purchased   from  another  producer.
 then  the applicant shall also comply
   HIM 40— frolecltcp «.f fnvlr*na«*a|

with f IMJ-I M to such active Ingredi-
ent, and the application shall contain
an acknowledgment that for purposes.
of PIPRA section »(oK|MD) the appli-
cation relies on (and any resulting reg-
istration should be regarded M If U
were based on the Administrator's con-
alderallon of) the following data:
  (|| All data aubmltted or specifically
cited  by the applicant In support of
MM registration; and
  CJ>  Bach other Item of 0>l* In MI*
'Agency's files which:
' (I) Concerns th* properties or effects,
Of any such act|ve Ingredient; and .
  (II)  I* one of the types of data, that
BPA. would require to be submitted for
adentlflo review by BPA If the apnli-
cant  sought the  InIMM  registration
Under PIFBA  Section  KcMI)  of  a
product  with composition and Intend-
ed uses Identical to MIOM proposed for
the  applicant's product under the
data  requirement* In effect on Ins
data  EPA  approve*  the  applicant'*
prcMn} application.
                                  APPENDIX V-l
            ivfreiMMNtal rr*f ocl>n A*j*ncjr
                                                                                                              1« 10
 VJMXIM *!•**>
  (a)  CtofMfwl-41) Orafmfi  ol 0N)
 totol  Every pesUekw product* ahal)
 bear a label containing MM tnforma-
 Mon specified by the Act and the regu-
 laMons bi this Tart. The content*, of a
 libel must show  dearly  and promi-
 nently the following:
  (I) The name, brand, or tredem«r»
 under which th* product h) sold upre-
 aoribed to paragraph (b)  of thb seo-
  (U) Tho name and address of MM
 producer,  registrant, or  peraon for
 whom produced M prescribed In para-
 graph (e) of this section;
  (111) Tho net content* M prescribed
 In paragraph (d) of this section:
  (!*)  The   product   registration
 number M prescribed In paragraph (e)
 of this section;
  (V)  The  producing  establishment
'number M prescribed In paragraph (f I
 of this section;
  (vl) An Ingredient atatement M pra-
 aerlbei) |n paragraph (g)  of this sec-
 tion;
  (vlll Warning or precautionary state-
ments M prescribed In, paragraph  such term* M to render It
likely to be read and understood by
the ordinary Individual under custom-
ary conditions of purchaM and use,
  (l|> All required label text must: \
  (A)  Be Ml In • point or larger type;
  (B)  Appear on a clear  contrasllng
background; and
  (C) Not be obscured or crowded.
  (|) f+nammot to bt usedl All required
label or labeling text «hal| appear la
the English language. However, th*
Agency may require or the applicant
may propoM additional text In other
languages M to considered neceaaary to
protect  MI* public. When additional
(axt In another language to necessary.
all  labeling requirement*  will be ap-
plied equally to both the English and.
other language versions of the label-
ing..   -     . -;        •.-.•:.'
  (4) JVactwMftf o/ taoef-d) CtourmL
'The Uoddiall appear on or be secure-
ly attached to MM Immediate  contain-
er of  MM pesticide product. For pur-
poses of this  Section, and MM Aito-
brand.« provision* Of |no Ad.  "M-
furely attacheoT slisll mean MuU •
label  can reasonably be expected to
remain affixed during  the  foreseeable
conditions and period ol UM. If the lift-
mediate container to enclosed within a
*r«PP«r or ouUlde container through
which M» label cannot be dearly read.
Ihe |abe| must also be securely  at-
tached to aueh outside wrapper or con-
tainer; If It  |a a part of |he package M
euslomarfly distributed or sold.
  (Ill fan* cart and other out* con-
faliier*-(A) rraniporfadon. While a
pesticide product to |n  transit, the ap-
propriate provisions of <• CPU Parts
110-IM. concerning the transportation
of hasardous malerlato. and specifical-
ly MIOM provtolons concerning the la-
beling, marking and placarding of has-
ardous materials and the vehicles car-
rying them, define Ihe basic Federal
requirement*. In addition, when  any
registered pesticide product to trans-
ported in a tank  car. tank truck or
other mobile or portable bulk iwnlaln-
er. a copy of tlie accepted label must
be attached  to  the snipping  papers.
»nd left with the consignee at Itie time
of delivery.
  (B) Storage.  Wtwn pesticide prod-
uct* are  stored  hi bulk container*.
Whether mobile or stationary,  which
remain In the custody of HM user, a
copy of the label of labeling. Including
all appropriate directions for UM. shall
be securely attached to the  container
m the Immediate  vicinity of the dis-
charge control valve.
  (I) fafM or mlifearflnr »latem«nU
Pursuant to aectlon KqK| MA) of the
Ad. » pesticide or a device declared
subject to the Act pursuant to 1161 la.
|* mtobranded If lla labellitg to lalse or
misleading In any particular HNjudlng
both  pesticldBl  and  nonpeallcltlal
ctoJma, Examples of statements or reu-
reMntatlons In MM labeling whWi con-
stitute mtobrandlng Include:
  (|) A fake or mUleadlng atatemeiH
concerning the composition of  the
product;
  (II) A fatoe or misleading statement
concerning UM  effectiveness  of  the
product M a pesticide or device; -
  (111) A fatoe or misleading statement
about  th* value  of the product for
purposes other than M a  peatlclde or
device;
  (Iv) A fatoe or misleading comparison
with other pesticides or devices;
  (y) Any alalement directly or Indi-
rectly Implying that the pesticide or
device b recommended or endorsed by
any  agency of the Pedersl  Uovern-
ment;
  (vl) The name of a peslldde which
contains two or more principal active
Ingredients If the  name suggests one
or more but not  all such  principal
active  Ingredients even l|iough  the
name*  of the other  Ingredient <  are
slated elsewhere In the labeling-;
                                         156

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I
 IIM.IO

   (vll) A true statement used In such a
 way M to clve a fabe or misleading Im-
 pression io the purchaser;
   (vlll) Label disclaimer* which negate
 or detract from labeling •tatemenU re-
 quired under the Act and, these ref u|a-
 llona;
    "pollution approved"
   (g) Final printed laoeffsjgt (I) Bxeept
 M provided lit paragraph (aXCMIU of
 Into  aecllon. final  printed,  labeling
 muat be aubmltted and accepted prior
 to registration. However,  final printed
 labeling need not be aubmltted until
 draft label texts, have been proyblon-
 elly accepted by the Agency.
   Ill) Clearly legible reprodneUora or
 photo reduction* will be  accepted for
 uniuual labela  tucli M Ihoao  eQk-
 acreened directly onto glaaa or metal
 container* or large bag or drum labela.
 Such reproduction* must  be of micro-
 film reproduction quality.
   pose a
                                                                                                                     hazard to niaii or the environment.
                                                                                                                       (h)  Warning*  and  precautionary
                                                                                                                      n/
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  IhoM required on MM Irani panel of
  the  labeling  and ihoM which  may
  appear  elsewhere. Specific  requlre-
  menU concerning content, placement.
  type size, and prominence ere given
  below.
   (I) Jteaufred front panel sfaiezMnfa.
  With the  exception  of the  child
                                  DUo 4*-fr.f.t!M of favlreemoHf

                                hazard warning statement, the text re-
                                quired on MM front pane) of the label
                                |s determined by the Toxlclty Catego-
                                ry of the pesticide. The category Is M-
                                •lined on the bub of  the  highest
                                hazard shown by any of the Indlcatqra
                                In the table below:
                                ' •

             l*»M*Mu*«SM fmSMSlMSMS - rtMl.OMftmM.OM. OiMtaf MM BI.CO*.
              M/W
   (|) ffHtnaii ftasanf sfeiiajf
 ifyCateporyf. All pesticide prod-
 meeting the criteria- of Toxlclty
gory I shall bear on  the from;
 ucU
 Category
 panel the signal word "Danger." In ad-
 dition If the product wee assigned to
 Toilclly Category I on the basis of Its
 oral.  Inhalation or dermal loxlclty (as
 distinct from skin and eye local ef-
 fects) the word "Poison" shall appear
 fat red on a background of dUtlitctly
 contrasting color and MM skull  and
 croMbones shall  appear In Immediate
 proximity to the word "poison."
  
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lions  |o  avo|d  potential  accident.
Injury or damage.. Biample*  of the
hazard  statement* and  |be circum-
stances under which they ere required
follow:
  (At  If a pesticide Intended, for out-
door UM contain* MI active Ingredient
with a mammalian acute oral |4X» of
100 or leu. thestatement Thto>esU-
elite U Toilo lo Wildlife* Is required-
  (Bl  If a pesticide Intended for out-
door UM contains an active Ingredient
vlth a lUh acute UX* of I ppm or less.
the statement Thto Pesticide to Toxlo
lo Hsh" to required.
  (0  If a peitkMo Intended for out-
door UM contains an aotlf • Ingredient
with an avlan acute oral UX. of 100
mg/kg or less, or a subacute  dietary
I A. of 100 ppm or lea. the statement
'This Pesticide to Toilo to
required.   *
                                     flHo 10-frotecHoN of f nvlr.n-«..|


                                     If either accident hUtory or f|eld
                                  studies demonstrate that use of tho
                                  pestlcfde  may result  In fatality  to
                                  plrds. fish or mammals, the statement
                                  Hrttls  pesticide to extremely toi|o.  to
                                  wildlife iflshT to required.
                                    (K) For uses Involving foliar applica-
                                  tion to agricultural crops, forests,  or
                                  shade trees, or for mosquito abate-
                                  ment  treatments, pesticides tox|o  to
                                  pollinating Insects fiust bear approprl-

                                    •,!•*•».
(I) OtmlloM jbr
          — 41)
                            Ctoiwral
     o/ 4lr« UN'-           •
   Jtecepffows fa r*att|f*>W*f for
 direction /or HM-IA) Petelled direc-
 tions for use may be omitted from la-
 beling of pesticides, which, are Intended
 for UM only by manufacturer* °' prod- {
 ucla other than pesticide products In
 |helr regular manufacturing processes.
 provided that:
 1 f J) The label clearly shows (hat the
 product to intended for UM only hi
 manufacturing processes and speclflef
 the type(s) of products Involved.
  (I) Adequate Information such M
 technical data sheets or bulletins, to
 available lo the trade specifying  the
 type of  product Involved  and   Ite
 proper UM  In manufacturing process-
 es;
  14) The product w|l| not «*«• feto
the hands of the general publlo except
after Incorporation Into finished prod-
•"•'•• tnd
     The Administrator determine*
     ••*!»' .ll»»..ll«—	«
                                                                                                                   and effectlveneM  of  tho  product for
                                                                                                                   pesticide purpoaes;
                                                                                                                     (I) Ttio |abe| c|early slates that the
                                                                                                                   l^oducl  to Intended  for UM only  In
                                                                                                                   manufacturing,  formulating, mixing.
                                                                                                                   Pr repacking for UM aa a pesticide and
                                                                                                                   •ped'tea Hie type(s) of peullcldi) prod
                                                                             .,, ...r «».«nnii»M»Mir qeiernunu,
                                                                            that such dlrecUons are not necessary
                                                                            to  prevent  unreasonable advene  ef-
                                                                            fecta on. man or the environment.   ,
                                                                             IB) DeUlled directions for UM. may
                                                                            be omitted from the labeling of pest|-
                                                                            rKi* nr.w!...!., i0t Whlch sale to	
                                                                                    label elcariy atetea that
                                                                           u1611 "• tolMtottot
      The statement  of UM classifica-
  tion (is prescribed In  1*110(1) Immedi-
  ately under the heading "Directions
  for MM."
   (II) Immediately below the  state-
  ment of UM classification, the state-
  ment "It to a violation of federal  law
  to us* this product In a manner Incon-
  sistent will) Ite labeling."
   IIP) The sltefa) of application, as for
  example the crops, annuals, areas, or
  objects, to be treated.
 • llv) The  target  pesMa) associated
  With each site.
   (V) The dosage rate associated with
 each alto and peak
   (vl).The method  of application.  In-
 cluding Instructions for dilution. If  re-
 quired, and typeta) of application ap-
 paratus or equipment required.
  e pesticide has been
 applied,   meeting  the  requirements
 concerning  reentry provided  by  40
 CPU Part 1YO.
  fix)  Specific directions  concerning
 fhe storage  and disposal of the pesti-
 cide and Ite container, meeting the re-
 quirements of |0 CVfl Part loB. These
 Instructions   sliall  be ground  and
appear under the heading "Storage
and DlspoM|." Tills  |te*dtng muat be
                                                                          159.'

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                                        APPENDIX V-l
f 142.1 T
t
             the saaui alBliBiim staav   beyond thoae pmpum tad uses ean-
arrequUad for the. etUld taaard wain-  tataed to the- Directions for Use win be
IB* (Se»Tial* la f la&lOfhXIXirU      considered a fate or mtalrartlnr state-
                                          Batrtettd. tfar Ctasri/ten.
                                    gftr  at**) daattted  rncrietad
                                   ^tanr statamtx of nsxncctd QM
                                              OB tte
                                      U) fnmt asacf ttatanatt of restrict-
                                   ,y'  ->BBi7 fortaoa* ttses cprued bytae Cer-
tfoa. Aay tmtfvtd* prodaes for waitir  ttftod  Apptlcaror'^ eertlflcatlan."'  U.
   ^ nmm^mrm H««^ftyf frt^ ff«»T^| n^^  BOWeTBR OtaBT rmilatflry mUlgtlOPl
    otam for rcstricxad on saall. to*  •*** latpuacd. toe AdaUalstrator will
      ily -.t^^ ma.mnrtin (0 ^^i^..  ^djiftot the appropriate wording- f or thr
       tandards* set fft***i to »«*• ntt-  ^tatsoa of restriction br resulatloa*
       •"** saail. to 'p*|l>^Mi1 as irnni    ^^ AdnarttslBC CRavirieiil
            . wtta dfitftfest ncfstn^  t luailiiy UUecUoas  Aoc. 1. WBc 40 PR sasti. And 21. UTS, u-
OBir* far ccneraL oaets) aad tae otacr  •o«adadrat u m 5788. *%*». 3. \srrm
       taat^lf a. product aaa tota- re—
                 srogaiasets). both

       ^^^^^ ^^^^^A^
       lor rvt
    ihifl tosnaja«cto
  CD    uro Ifte C3to
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