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                                  DISCLAIMER







    This report  Is  an external draft  for  review purposes only and  does  not



constitute  Agency  policy.   Mention  of  trade names  or   commercial  products



does not constitute endorsement or recommendation for use.
                                      11

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                                   PREFACE

    Health and  Environmental  Effects  Documents (HEEDs) are prepared  for  the
Office of  Solid  Waste  and  Emergency  Response  (OSWER).  This  document  series
Is Intended to support listings under  the  Resource  Conservation  and  Recovery
Act  (RCRA)  as   well  as  to  provide   health-related   limits  and  goals  for
emergency  and   remedial   actions   under  the   Comprehensive  Environmental
Response,  Compensation   and   Liability  Act   (CERCLA).     Both   published
literature and   information  obtained   for  Agency  Program  Office  files  are
evaluated  as  they  pertain  to  potential  human health,  aquatic  life  and
environmental   effects   of   hazardous   waste   constituents.    The  literature
searched  for   In this  document  and   the  dates searched  are  Included  In
"Appendix: Literature  Searched."   Literature  search  material Is  current  up
to 8  months   previous  to the  final  draft date listed on  the  front  cover.
Final draft  document  dates  (front  cover)  reflect  the date  the document  Is
sent to the Program Officer  (OSWER).

    Several quantitative  estimates are  presented  provided  sufficient  data
are  available.    For   systemic  toxicants,   these   Include:  Reference  doses
(RfDs) for chronic and subchronlc exposures  for  both  the  Inhalation  and oral
exposures.  The  subchronlc   or  partial  lifetime  RfO,  Is an  estimate  of  an
exposure  level  which  would  not be expected  to  cause adverse  effects  when
exposure occurs  during  a  limited time  Interval  I.e.,  for an Interval  which
does  not  constitute a  significant  portion  of  the  llfespan.  This type  of
exposure estimate has  not been  extensively  used,  or rigorously  defined  as
previous rlsfc assessment efforts have  focused  primarily on  lifetime  exposure
scenarios.   Animal  data  used  for subchronlc  estimates  generally  reflect
exposure durations  of  30-90  days.   The general methodology  for  estimating
subchronlc RfDs   1s the same  as  traditionally employed for  chronic  estimates,
except that subchronlc  data  are utilized  when available.

    In the case  of  suspected carcinogens,  a  carcinogenic potency  factor,  or
q-j*  (U.S.  EPA,   1980),  1s  provided.   These potency  estimates  are  derived
for both  oral and  Inhalation  exposures  where  possible.   In  addition,  unit
risk estimates for air  and  drinking  water  are presented  based on  Inhalation
and oral data, respectively.  An,.RfD may also  be derived  for  the noncarclno-
genlc health  effects of compounds  that  are  also carcinogenic.

    Reportable   quantities   (RQs)   based  on   both   chronic   toxlclty  and
carclnogenldty  are derived.  The  RQ  Is  used  to determine  the quantity of a
hazardous  substance  for which  notification  Is  required  In  the event of  a
release  as   specified   under  the  Comprehensive   Environmental   Response,
Compensation   and Liability  Act  (CERCLA).    These  two RQs  (chronic  toxlclty
and cardnogenlclty)  represent two of  six  scores  developed  (the remaining
four reflect  IgnltabllUy, reactivity, aquatic toxlclty,  and  acute mammalian
toxlclty).  Chemical-specific  RQs  reflect  the  lowest  of  these six  primary
criteria.  The  methodology  for  chronic  toxlclty  and  cancer  based RQs  are
defined In U.S.  EPA, 1984 and 1986a,  respectively.
                                      111

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                              EXECUTIVE SUMMARY

    ds-l,2-D1chloroethy1ene Is a  volatile,  colorless liquid and  1s  soluble
In water and  common  polar  or nonpolar organic solvents.   In  1977,  between  1
and  11  million  pounds  of  cls-1,2-d1chloroethylene  was  produced  by  PPG
Industries at  their  production facilities  In Lake  Charles,  LA, and  Ponce,
Puerto  R1co  (TSCAPP,  1989).  Recent  production  volume  data  are not  avail-
able.   ds-1,2-D1chloroethylene  1s produced  by  the partial  chlorlnatlon  of
acetylene, and  1t 1s separated from the trans-1somer  by  fractional  distilla-
tion  (Stevens,  1979).   ds-1,2-D1chloroethylene  1s also produced  during  the
manufacture  of  other  chlorinated  solvents.   Most  cls-1,2-D1chloroethylene
produced commercially Is used directly In the synthesis  of other chlorinated
solvents.   It  Is  also  used as   a  low  temperature extraction  solvent,  a
solvent  for  organic  synthesis and as a  solvent  for specialty  applications
(Sax and Lewis,  1987;  Stevens,  1979).
    ds-1,2-D1chloroethylene  Is  expected  to   exist  almost entirely  1n  the
vapor  phase   1n  the atmosphere.   Its  atmospheric  fate  1s  expected  to  be
dominated by  the  gas  phase destruction by photochemlcally  produced hydroxyl
radicals; the half-life  for  this  process  can   be estimated  at 8.3  days  based
on an  experimentally  determined rate  constant.   Wet deposition of ds-1,2-
dlchloroethylene may  occur;  however,  any  compound removed  from  the  atmo-
sphere  by  this  process  Is  expected  to  volatilize  again   quickly.   Neither
direct photochemical degradation nor gas  phase destruction  by ozone or  other
chemical  oxldants  Is  expected  to  occur  to  any  significant extent  In  the
atmosphere.
    The  fate  of ds-1,2-d1chloroethylene  In  surface water   Is expected  to  be
dominated by  rapid  volatilization  to  the  atmosphere.  The  half-life  for  the
volatilization  of ds-1,2-d1chloroethylene  from  a model river  Is  ~3  hours.
                                      1v

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Although  m1crob1al  degradation  of  ds-1,2-d1chloroethylene  under  anaerobic
conditions  Is  known  to  occur,  H occurs  at a slow rate.  There are conflict-
ing  data  regarding  the degradation  of  this  compound  under  aerobic  condi-
tions.  It  appears  that some organisms are  capable  of  degrading cls-1,2-dl-
chloroethylene  under  aerobic conditions  If  suitable  nutritional  sources  are
present.   The  destruction  of  ds-1,2-d1chloroethylene 1n  water by  direct
photolysis  or  by abiotic chemical degradation  Is  not  expected to be signifi-
cant.   c1s-l,2-D1chloroethylene 1s  not  expected  to  bloconcentrate  signifi-
cantly  In  fish and  aquatic  organisms   nor  1s  1t  expected  to adsorb  to
sediment and suspended organic matter.
    Limited  experimental  data  on  the fate  of  cls-1,2-d1chloroethylene  In
soil  were  located  1n the available  literature.  It may be  highly  mobile  1n
soil  and  leach  Into  groundwater.   c1s-l,2-D1chloroethylene  will  volatilize
readily from  the  soil  surface to the  atmosphere.   It  Is  expected to undergo
slow  microblal  degradation  1n  anoxlc  soils  and  groundwater.   A  recent
experiment  Indicated   that   this   process   may  also   occur  under   aerobic
conditions  with  certain microorganisms 1f secondary  nutritional  sources  are
available.
    ds-1,2-D1chloroethylene may  be  released to  the  atmosphere  1n  emissions
from  Us  production and use and from the  volatilization  from  contaminated
wastewater  or  from  waste disposal sites,  ds-1,2-Dlchloroethylene  may also
be released to  the  environment  as a  result of  the combustion of poly(vlnyl)-
chlor.lde  polymers   or   as  a  result   of  the  biological breakdown  of  other
chlorinated solvents.
    Occupational exposure  to c1s-l,2-dlchloroethylene  may  occur by  Inhala-
tion  or dermal contact  during  Us  manufacture,  transportation  or  use as  a
solvent or  chemical  Intermediate.   Exposure  by Inhalation  1s  also  likely  1n
areas, such as landfills, where cls-1,2-d1chloroethylene Is  discarded.

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    c1s-1,2-D1ch1oroethylene  has  been  detected   In  surface  water,  ground-
water, rainwater and  drinking  water.   Consequently,  exposure to the general
population  can  occur  by  drinking contaminated  water.   Since ds-l,2-d1-
chloroethylene  has  been  detected  In  tap  water, exposure  to  the  general
population  may  occur  by  dermal   contact  or  Inhalation  while bathing  or
showering,   ds-1,2-D1chloroethylene  has  also  been  detected  In  urban air
samples.    Based on an  analysis  of urban  air  levels  of ds-l,2-d1chloro-
ethylene  (Shah and Heyerdahl, 1988), a median dally Inhalation  Intake can be
calculated   as   3.96   yg/day.    Sufficient   data  are   not  available  to
accurately  estimate human  exposure to  l,2--d1chloroethylene  by other routes
of exposure.
    Pertinent data regarding the  environmental toxldty of ds-l,2-d1chloro-
ethylene were not  located  1n  the available  literature  cited 1n Appendix A.
    Pharmacok1net1c data   for   ds-l,2-d1chloroethylene   are  limited.   Gas
uptake studies  Indicate  that  c1s-l,2-d1chloroethylene  Is  absorbed  readily
from  the  respiratory  tract  of rats  (FUser  and Bolt,  1979).   Because the
compound   1s  neutral,  low molecular  weight  and UpophlUc, It Is expected to
be  readily absorbed  by  any  natural  route of  exposure  (U.S.  EPA,  1987a).
Although   tissue distribution  data  were  not located,  the  highest tissue
levels would be expected In  the liver and  kidneys (U.S.  EPA,  1987a), 1f this
compound  behaves similarly to 1 ,l-d1chloroethylene (McKenna et al., 1978).
    ds-1,2-D1chloroethylene   Is  metabolized  by  hepatic  cytochrome   P-450
oxldases,   with  the  formation  of  dlchloroacetaldehyde  and   dlchloroethanol
(Costa and  Ivanetlch,  1982).   The  Initial step  In  the metabolism  probably
Involves   formation of a  chloroethylene epoxlde that  undergoes  rearrangement
to  dlchloroacetaldehyde   (Henschler,   1977;   Lelbman  and  Ortiz,  1977).
                                      v1

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Metabolic  elimination  of ds-1,2-d1chloroethylene was  described  as  a satur-
able process,  changing  from a first-order to a  zero-order  process  at 20 ppm
(Fllser and Bolt, 1979).
    Pertinent  data   regarding   the   excretion   of  ds-1,2-dlchloroethylene
following  oral,   Inhalation  or  dermal  exposure  were  not   located  1n  the
available  literature dted  In Appendix A.
    Acute  Inhalation exposure of animals  or  humans  to  high  concentrations of
ds-1,2-d1chloroethylene vapors  can  produce  anesthesia  and  narcosis  (Smyth,
1937-1955; ACGIH,  1986).   In rats, exposure to  16,000 ppm  ds-1,2-dlchloro-
ethylene for 4 hours resulted 1n death (Smyth,  1937-1955).
    The  results  of  an  acute  oral  toxlclty  rat  study  provided  biochemical
evidence   that  ds-1,2-d1chloroethylene  1s   hepatotoxlc  (Jenkins   et   al.,
1972).    ds-l,2-01chloroethylene  significantly  elevated  the  activity  of
liver  alkaline  phosphatase at  the   400  and 1500  mg/kg dose levels.   The
activities of  liver glucose-6-phosphatase,  liver tyroslne  transamlnase  and
plasma alanlne transamlnase decreased at the  1500 mg/kg dose level.
    The  systemic  toxlclty   resulting  from subchronlc  or  chronic  exposure to
ds-l,2-d1chloroethylene,  either  by   Inhalation  or  oral  administration,  has
not been examined.
    Pertinent  data  regarding  the  carclnogenlclty or  developmental  toxlclty
of  ds-1,2-d1chloroethylene to  animals  or  humans  exposed   by  any  route to
this chemical were not  located  1n  the available  literature  cited  In Appendix
A.  cls-1,2-D1chloroethylene  yielded  a  positive result  In  a  host-mediated
assay  using  £. cerlvlslae  07  strains In mice  (Bronzettl et al.,  1984)  but
did  not  cause  chromosomal  aberrations  or   sister  chromatid  exchanges  In
Chinese hamster cells 1n vitro (Sawada et al.,  1987).

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    Because of the lack of cancer data In either humans or animals, ds-1,2-
dlchloroethylene was assigned to U.S. EPA we1ght-of-ev1dence group D: cannot
be classified as to cardnogenldty to humans.  Data were not available from
which  to  estimate potency  slope factors or  to assign  an RQ  for cardno-
genldty.
    Sufficient  chemlcal-spedf 1c  subchronlc  or  chronic  noncancer toxlclty
data were  not  available  for derivation  of  RfD  values  for ds-l,2-d1chloro-
ethylene.   The  RfO  of  0.009 mg/kg/day for  chronic  oral  exposure  to I,l-d1-
chloroethylene  was  adopted  for  subchronlc  and  chronic  oral   exposure  to
ds-1,2-d1chloroethylene.    The  Agency  had  previously  determined  that  the
metabolism and  effects  of  exposure  to  the  dlchloroethylenes  are similar
(U.S.  EPA,  1987a,b).   Using similar  logic,  a  previously  derived chronic
toxlclty  RQ   of  1000   derived   for   1,1-dlchloroethylene  was   adopted  for
ds-1,2-d1chloroethylene.

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                             TABLE  OF  CONTENTS

                                                                       Page
1.  INTRODUCTION	     1

    1.1.   STRUCTURE AND CAS NUMBER	     1
    1.2.   PHYSICAL AND CHEMICAL PROPERTIES 	     1
    1.3.   PRODUCTION DATA	     2
    1.4.   USE DATA	     2
    1.5.   SUMMARY	     2

2.  ENVIRONMENTAL FATE AND TRANSPORT	     4

    2.1.   AIR	     4

           2.1.1.   Reaction with Hydroxyl  Radicals 	     4
           2.1.2.   Reaction with Ozone and Other Oxldants	     4
           2.1.3.   Photolysis	     4
           2.1.4.   Physical Removal Processes	     5

    2.2.   WATER	  .-	     5

           2.2.1.   Hydrolysis	     5
           2.2.2.   Oxidation 	     5
           2.2.3.   Photolysis	     5
           2.2.4.   M1crob1al Degradation 	     5
           2.2.5.   Bloconcentratlon	     6
           2.2.6.   Adsorption	     6
           2.2.7.   Volatilization	     6

    2.3.   SOIL	     7

           2.3.1.   M1crob1al Degradation 	     7
           2.3.2.   Adsorption	     7
           2.3.3.   Volatilization	     7

    2.4.   SUMMARY	     8

3.  EXPOSURE	    10

    3.1.   WATER	    10
    3.2.   FOOD	    11
    3.3.   INHALATION	    11
    3.4.   DERMAL	    11
    3.5.   OTHER	    11
    3.6.   SUMMARY	    12
                                     1x

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                          TABLE  OF  CONTENTS (cent.)

                                                                       Page
4.  ENVIRONMENTAL TOXICOLOGY	   13

    4.1.   AQUATIC TOXICOLOGY 	   13

           4.1.1.   Acute Toxic Effects on Fauna	   13
           4.1.2.   Chronic Effects on Fauna	   13
           4.1.3.   Effects on Flora	   13
           4.1.4.   Effects on Bacteria 	^_	   13

    4.2.   TERRESTRIAL TOXICOLOGY 	   13

           4.2.1.   Effects on Fauna	   13
           4.2.2.   Effects on Flora	   14

    4.3.   FIELD STUDIES	   14
    4.4.   AQUATIC RISK ASSESSMENT	   14
    4.5.   SUMMARY	   14

5.  PHARMACOKINETCS	   15

    5.1.   ABSORPTION	   15
  ,  5.2.   DISTRIBUTION	   15
    5.3.   METABOLISM	   15
    5.4.   EXCRETION	   16
    5.5.   SUMMARY	   16

6.  EFFECTS	   19

    6.1.   SYSTEMIC TOXICITY	   19

           6.1.1.   Inhalation Exposure 	   19
           6.1.2.   Oral Exposure	   19
           6.1.3.   Other Relevant Information	   20

    6.2.   CARCINOGENICITY	   21

           6.2.1.   Inhalation	   21
           6.2.2.   Oral	   21
           6.2.3.   Other^ Relevant Information	   21

    6.3.   GENOTOXICITY	   21
    6.4.   DEVELOPMENTAL TOXICITY 	   25
    6.5.   OTHER REPRODUCTIVE  EFFECTS 	  	   25
    6.6.   SUMMARY	   25

7.  EXISTING GUIDELINES AND STANDARDS 	   27

    7.1.   HUMAN	   27
    7.2.   AQUATIC	   27

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                           TABLE  OF  CONTENTS  (cont.)

                                                                        Page
 8.  RISK ASSESSMENT	   28

     8.1.   CARCINOGENICITY	   28

            8.1.1.   Inhalation	   28
            8.1.2.   Oral	   28
            8.1.3.   Other Routes	   28
            8.1.4.   Weight of Evidence	   28
            8.1.5.   Quantitative Risk Estimates 	   28

     8.2.   SYSTEMIC TOXICITY	   28

            8.2.1.   Inhalation Exposure 	 ...   28
            8.2.2.   Oral Exposure	   29

 9.  REPORTABLE QUANTITIES 	   31

     9.1.   BASED ON SYSTEMIC TOXICITY 	   31
     9.2.   BASED ON CARCINOGENICITY	   33

10.  REFERENCES	   34

APPENDIX A: LITERATURE SEARCHED	   46
APPENDIX B: SUMMARY TABLE FOR ds-1,2-DICHLCIROETHYLENE	   49
APPENDIX C: DOSE/DURATION RESPONSE GRAPH(S) FOR EXPOSURE TO
            C1S-1.2-DICHLOROETHYLENE 	   50
                                      x1

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                            LIST OF ABBREVIATIONS

AEL                     Adverse-effect level
BCF                     Bloconcentratlon factor
CAS                     Chemical  Abstract Service
CS                      Composite score
PEL                     Frank  effect level
HA                      Health advisory
HID                     Highest Ineffective dose
Koc                     Son sorptlon  coefficient
Kow                     Octanol/water  partition  coefficient
L05Q                    Dose lethal  to 50% of recipients
LOU                     Log dose  unit
LEO                     Lowest effective dose
LOAEL                   Lowest-observed-adverse-effect level
MED                     Minimum effective dose
ppb                     Parts  per billion
ppm                     Parts  per million
RfD                     Reference dose
RQ                      Reportable quantity
RV(j                     Dose-rating value
RVe                     Effect-rating  value
STEL                    Short-term exposure level
TLV                     Threshold limit value
TWA                     Time-weighted  average
UV                      Ultraviolet

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                               1.   INTRODUCTION
1.1.   STRUCTURE AND CAS NUMBER
    ds-l,2-D1ch1oroethylene   1s   known   by   the   synonyms  els-acetylene
dkhlorlde,  Z-acetylene dlchlorlde,  ds-1,2-d1chlorethylene  and  Z-l,2-d1-
chlorethylene  (Chemllne,  1989).    The  structure,  CAS  number,  empirical
formula and molecular weight are as  follows:
 H
                                         H
                                    \
                                     C=C
                                        \
Cl
                                         Cl
CAS Registry number:   156-59-2
Empirical formula:   C-HpCl-
Molecular weight:   96.94
1.2.   PHYSICAL AND CHEMICAL PROPERTIES
    ds-1,2-D1chloroethylene  Is a  colorless; liquid at  room temperature and
1s  soluble  1n  water  and common polar  or  nonpolar  organic solvents (Sax and
Lewis, 1987; Weast et al.,  1988).  It  has a  slight  ether-Uke odor  (Wlndholz
et  al.,  1983).  Selected  physical  and chemical properties  for ds-l,2-d1-
chloroethylene are given below:
    Melting point:                 -80.5°C
    Boiling point:                 60.3°C
    Water solubility at 25°C:      3500  mg/a.
    Vapor pressure  at 25°C:        215 mm Hg
    Log Kow:                      1.86
    Flash point:                   6°C
    Conversion factors at 25°C:    1  ppm =  3.96  mg/m3;
                                  1  mg/m3  =0.25  ppm
                     Weast et al., 1988
                     Weast et al., 1988
                     Horvath, 1982
                     Stevens, 1979
                     Hansch and Leo, 1985
                     Stevens, 1979
0267d
  -1-
12/19/89

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 1.3.    PRODUCTION DATA
    Between  1  and  11  million pounds of ds-1,2-dlchloroethylene was produced
 In  1977 by  PPG  Industries at  their  production facilities  1n  Lake Charles,
 LA, and Ponce, Puerto  R1co  (TSCAPP,  1989).  Production at  the  Lake Charles
 plant  was  listed as  site-limited.   More  recent  production volume  data  are
 not available.
    cls-1,2-D1chloroethylene  Is  produced  by  the   partial  chlorlnatlon  of
 acetylene  at  40°C.   Separation  from  the  trans-1somer   1s  performed  by
 fractional  distillation,   ds-1,2-D1chloroethylene  Is  also produced  as  a
 by-product of  the manufacture of other chlorinated compounds (Stevens, 1979).
 1.4.    USE DATA
    ds-1,2-D1chloroethylene  Is  used  primarily  as a  chemical  Intermediate In
 the   synthesis   of   other   commercially  significant  chlorinated  solvents.
 ds-1,2-D1chloroethylene   Is  also   used   as  a  low-temperature  extraction
 solvent  for  organic materials such  as  dyes, perfumes,  lacquers  and thermo-
 plastics,  and  as a solvent  for  organic  synthesis  (Stevens,  1979;  Sax  and
 Lewis,  1987).
 1.5.    SUMMARY
    cls-1,2-D1chloroethylene  1s  a  volatile, colorless  liquid and Is soluble
 In water and  common polar  or nonpolar  organic  solvents.   In  1977,  between 1
 and  11  million   pounds of   cls-1,2-dlchloroethylene   was  produced  by  PPG
 Industries at  their production  facilities In  Lake  Charles,  LA, and Ponce,
 Puerto  R1co  (TSCAPP,  1989).  Recent  production volume data  are not avail-
 able.    ds-1,2-D1chloroethylene  1s  produced  by the partial  chloMnation of
 acetylene,  and 1t 1s  separated  from  the trans-lsomer by fractional  distilla-
 tion  (Stevens, 1979).   c1s-l,2-D1chloroethylene Is  also produced during  the
manufacture  of other  chlorinated  solvents.   Most  ds-1,2-dlchloroethylene
0267d                               -2-                              02/07/90

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produced commercially Is used directly In the  synthesis  of  other  chlorinated
solvents.   It   Is  also  used as  a  low  temperature  extraction  solvent,  a
solvent  for  organic  synthesis and  as  a  solvent  for  specialty  applications
(Sax and Lewis, 1987; Stevens, 1979).
0267d                               -3-                              12/19/89

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                     2.  ENVIRONMENTAL FATE AND TRANSPORT
2.1.   AIR
    The  vapor  pressure  of  ds-1,2-d1chloroethylene  (215  mm  Hg)  at  25°C
(Stevens,  1979)  suggests  that  this  compound  will  exist almost  entirely  In
the vapor phase 1n the atmosphere (Elsenrelch et al., 1981).
2.1.1.   Reaction  with  Hydroxyl  Radicals.   The  dominant  atmospheric  fate
process  for  ds-1,2-d1chloroethylene  1s  expected  to  be destruction  by  the
gas phase  reaction with  photochemlcally  produced hydroxyl  radicals.  Experi-
mental  rate  constants for  this  reaction  have  been determined  at 2.0xlO"12
cmVmolecule-sec at  25°C (Goodman et  al.,  1986),   Indicating a  half-life  of
8.3 days  at  an average  atmospheric  hydroxyl  radical concentration  of  5xl05
molecules/cm3.
2.1.2.   Reaction  with Ozone and Other Oxldants.   Experimental  data  on  the
gas phase  reaction of ds-1,2-d1chloroethylene  with ozone,  nitrate radicals
or singlet oxygen  Indicate that  these reactions are too slow to be environ-
mentally  significant  (Atkinson  and  Carter,   1984;  Atkinson  et  al.,  1987;
Sanhueza and  Helcklen 1975a,b).  N1k1  et al.  (1983)  reported  that  the  gas
phase reaction of  ds-1,2-dlchloroethylene with  ozone was  a relatively rapid
reaction under  controlled  experimental conditions, but  concluded  that  since
free radical  scavengers  drastically  reduce the rate of  this  reaction,  1t  1s
not significant under atmospheric conditions.
2.1.3.   Photolysis.   The  primary  UV   band  for   c1s-l ,2-d1chloroethylene
extends  from  -190-240 nm  (Ausubel  and Wljnen,  1975).   Since this  compound
does   not  adsorb significant  amounts  of  radiation at  wavelengths  >290  nm,
atmospheric removal by direct photolytlc  degradation Is  not  expected to be a
significant process.
0267d                                -4-                              02/07/90

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2.1.4.   Physical  Removal  Processes.   1,2-D1chloroethylene  has  been  found
In rainwater  (Kawamura and Kaplan, 1983).  Wet  depostlon  from  the atmosphere
Is a  likely  atmospheric  removal  process.   Any  1,2-d1chloroethylene  removed
from  the  atmosphere by  this  process,  however,  is  expected to  revolatHIze
rapidly to the atmosphere.
2.2.    WATER
2.2.1.   Hydrolysis.   Hydrolysis   of   1,2-d1chloroethylene   1n  water   Is
expected  to  be slow and  should not be  an environmentally significant  fate
process (Jaber et al.,  1984;  Mabey et al.,  1981).
2.2.2.   Oxidation.  Data specific to  the  chemical  oxidation of  ds-l,2-d1-
chloroethylene 1n  water  were not  located  In  the available literature  dted
In  Appendix  A.    By  analogy  to  other  chlorinated  ethylenes,  H  Is  not
expected to be a significant  process  (DllUng  et al.,  1975).
2.2.3.   Photolysis,  ds-1,2-D1chloroethylene does not adsorb  light  1n  the
environmentally  significant   range  >290   nm   (Ausubel  and  Wljnen,   1975);
therefore, direct photochemical degradation 1n water  Is not expected  to be a
significant fate process.
2.2.4.   M1crob1al  Degradation.   cls-1,2-D1chloroethylene  undergoes   slow
reductive  dechlorlnatlon  under   anaerobic   conditions.    ds-1,2-D1chloro-
ethylene, when  Incubated  with  methanogenlc aquifer material obtained  near  a
landfill, underwent mlcroblal  degradation  under  anaerobic  conditions.   After
16 weeks,  >98X of this  compound  had been  removed by biological  degradation
(Wilson et  al.,  1986).   When  5  mg/a of ds-1,2-dlchloroethene  was added to
anoxlc microcosms  containing water  and  sediment,  the half-life  for  removal
was 88-339 days.   This  compound degraded  to chloroethane  and  vinyl  chloride
(Barr1o-Lage et al., 1986).
0267d                               -5-                              12/19/89

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    c1s-l,2-D1chloroethylene has  been  found  to resist mlcroblal  attack under
aerobk  conditions  (Fogel  et  al.,  1986).   Tabak  et  al.   (1981),  however.,
determined   that   ds-1,2-dlchloroethylene   was   susceptible  to  biological
degradation,  using  a  settled  domestic  wastewater  Inoculum.   In  sediment
samples  obtained  from  a  cattail  marsh, 660 ppb  cls-1,2-dlchloroethylene
completely  degraded  after  50 hours under aerobic conditions  with  methane as
a  secondary nutrient source (Fogel  et  al.,  1986).   It  appears  that aerobic
blodegradatlon  of  ds-1,2-dlchloroethylene  may  occur  In   the  presence  of
suitable microorganisms and nutrients.
2.2.5.   B1oconcentrat1on.   A   BCF  of   15  can  be  obtained  for   ds-l,2-dl-
chloroethylene  using  the linear  regression  equation  log BCF -  0.76 log  K
-  0.23  (Bysshe,  1982)  and  the  KQW reported  1n  Section  1.2.    This  value
suggests that  bloaccumulatlon  In  fish  and aquatic  organisms  1s  not  expected
to be a significant fate process.
2.2.6.   Adsorption.   Soil  adsorption  coefficients ranging  from  49-254  can
be  estimated  for  ds-1,2-dlchloroethylene  (Section  2.3.2.).   These  values
suggest  that  this compound will  not  adsorb  strongly  to  soil, therefore,  It
1s  not  expected  to  adsorb significantly  to  sediment and suspended organic
matter In aquatic systems.
2.2.7.   Volatilization.    An   experimental   Henry's   Law   constant   of
4.08xlO~3  atm-mVmol   at  24.8°C  has  been  determined  for  cls-1,2-dlchloro-
ethylene (Gossett, 1987).  Based  on  this  value,  the estimated volatilization
half-life  from a  model  river  1  m  deep,  flowing  at  1  m/sec  with a  wind
velocity of 3  m/sec  Is  ~3  hours  (Thomas,  1982).    In  the   laboratory,  the
volatilization  rate  of  ds-l,2-d1chloroethylene  from  a   rapidly   stirred
solution was  determined  and  the author  estimated  that the  corresponding
volatilization  half-life from  a  body  of  water  1  m  deep would be  5  hours


0267d                               -6-                              12/19/89

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(D1ll1ng,  1977).   It  Is  expected  that  volatilization  from water  to  the
atmosphere will be a  dominant fate process.
2.3.   SOIL
2.3.1.   M1crob1al Degradation.   Limited  data on  the mlcroblal  degradation
of ds-1,2-dlchloroethylene  In soil were  located  1n  the  available literature
dted 1n Appendix A.  Experimental  studies  have  shown that  cls-1,2-dlchloro-
ethylene can  undergo mlcroblal  degradation using  Inocula  from  groundwater
microcosms (Barr1o-Lage  et a!.,  1986;  Wilson et  al.,  1986);  therefore,  this
compound may  undergo biological  degradation under  anaerobic conditions  In
soil.  Henson  et  al.  (1989)  reported  that a mixed culture  of soil  organisms
acclimated to  chlorinated  hydrocarbons  completely  degraded  ds-1,2-dlchloro-
ethylene 1n 8  days under aerobic  conditions  using  methane gas as  a  nutrient.
The  biological  degradation  of  ds-1,2-d1chloroethylene  1n  soil,  therefore,
appears   to  be a  likely  fate  process  under  both  aerobic  and  anaerobic
conditions.
2.3.2.   Adsorption.   A  soil  adsorption coefficient  of  245 can  be  obtained
using  the  linear  regression  equation  log  K    =  0.544  log K    +  1.377
(Lyman,   1982)  and   the  K    reported  In  Section   1.2.   Using  the  water
solubility reported  In   Section  1.2.   1n  the regression  equation log K    =
-0.55 log  S  *  3.64  {Lyman,  1982), a  K   of 49  Is   obtained.  These  values
suggest   that ds-1,2-dlchloroethylene will be highly  to  moderately  mobile In
soil  (Swann   et  al.,  1983);  therefore,  cls-1,2-dlchloroethylene  has  the
potential to  leach Into  groundwater.
2.3.3.   Volatilization.   The  relatively  high vapor  pressure  of  cls-1,2-dl-
chloroethylene, 215  mm   Hg  (Stevens,   1979),  and  the expectation  that  this
compound will  not adsorb strongly to  soil  (see Section  2.3.2.)  suggest  that
It will  readily volatilize  from the soil surface  to the atmosphere.
0267d                               -7-                              02/07/90

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2.4.   SUMMARY
    ds-1,2-01chloroethylene  1s  expected  to  exist almost  entirely  In  the
vapor  phase  In   the  atmosphere.   Its  atmospheric  fate  Is  expected  to  be
dominated  by  the gas phase destruction by  photochemlcally produced hydroxyl
radicals;  the  half-life  for  this process can  be  estimated at 8.3 days based
on  an  experimentally determined  rate  constant.  Wet  deposition  of cls-1,2-
dlchloroethylene  may occur;  however,  any  compound removed  from  the atmo-
sphere  by this  process  Is expected  to volatilize again  quickly.   Neither
direct photochemical degradation  nor gas phase destruction by ozone or other
chemical  oxldants  Is  expected  to  occur to  any  significant  extent  In  the
atmosphere.
    The  fate  of  cls-1,2-d1chloroethylene  In surface water  1s  expected to  be
dominated  by  rapid  volatilization to the atmosphere.  The half-life for  the
volatilization of ds-1,2-d1chloroethylene  from  a  model  river Is  -3 hours.
Although  mlcroblal  degradation  of  ds-1,2-d1chloroethylene  under  anaerobic
conditions \s  known  to occur.  It  occurs  at  a  slow rate.   There are conflict-
ing  data  regarding  the  degradation of  this   compound under   aerobic  condi-
tions.   It appears  that  some  organisms are capable  of degrading  cls-1,2-d1-
chloroethylene under aerobic  conditions  If suitable nutritional  sources  are
present.   The destruction  of  cls-1,2-dlchloroethylene   In water  by  direct
photolysis or  by  abiotic chemical degradation  1s  not expected to  be signifi-
cant.   cls-1,2-Olchloroethylene 1s  not  expected to bloconcentrate signifi-
cantly  In  fish   and  aquatic  organisms   nor   Is  It  expected  to  adsorb  to
sediment and suspended  organic matter.
    Limited  experimental  data  on  the  fate  of  cls-1,2-d1chloroethylene  In
soil were  located 1n the available  literature.  It may  be highly  mobile  In
soil and leach  Into groundwater.  cls-1,2-D1chloroethylene  will  volatilize

0267d                               -8-                              12/19/89

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readily from the  soil  surface  to the atmosphere.   It  Is  expected  to undergo
slow  mlcroblal   degradation   1n  anoxlc  soils  and  groundwater.   A  recent
experiment  Indicated  that  this  process  may   also   occur   under   aerobic
conditions with  certain  microorganisms  if secondary nutritional  sources  are
available.
0267d                               -9-                              12/19/89

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                                 3.  EXPOSURE

    1,2-D1chloroethylene may  be  released  to  the  atmosphere  1n emissions  from
 Us   production   and  use  and  by   the   volatilization   from  contaminated
 wastewater  or  from waste disposal  sites.  It can  be  formed  from the pyroly-
 sls or  combustion  of poly(v1nyl)chlor1des  and  some vinyl  copolymers  (Mkhal,
 1976;  Shen, 1982).   1,2-01chloroethylene  Is  known to enter  the environment
 as  a  result of  the  anaerobic breakdown of other  chlorinated  solvents,  most
 notably  tetrachloroethane  and  1,1,2-trlchloroethylene  (CUne  and  V1ste,
 1985; Hallen et a!., 1986; Parsons  et al., 1984).
    According  to  an  occupational  survey  conducted   by  NIOSH  (1989),   215
 people  are  potentially  exposed to 1,2-d1chloroethylene  In   the  workplace.
 Occupational exposure  may  occur  by  Inhalation  of 1,2-d1chloroethylene  vapors
 or dermal contact during Us production or use.
 3.1.   WATER
    ds-1,2-D1chloroethylene  has  been  detected  1n  drinking   water,  ground-
 water and  surface  water.   It  has been  qualitatively detected  In the  drinking
 water  of  Philadelphia, PA  (Suffet  et al., 1980).  In a  survey of  drinking
 water  supplies  conducted  throughout  the United  States,  ds-1,2-d1chloro-
 ethylene was  found 1n 16  of  466 random sites  at  a maximum concentration  of
 2.0 ppb, and  1n  38 of 479 nonrandom sites at a  maximum concentration  of  120
                                                i
 ppb  (WestMck  et  al.,  1984).   It  was detected 1n  samples  taken  from  the
 Indian  River,  FL,  at  a  concentration of  4.0-48.1  ppb {Wang   et al.,  1985).
 In  groundwater surveys,  ds-1,2-dlchloroethylene  was  detected In  Nebraska
 (2.9  ppb  maximum  concentration)  and  Wisconsin  (Goodenkauf  and Atkinson,
 1986;   KM11 and  Sonzognl, 1986).   cls-1,2-D1chloroethylene   has  also  been
detected In groundwater  samples obtained  near  sites  of  chlorinated organic


0267d                               -10-                             02/07/90

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solvent  use or  hazardous  waste  sites  (Cllne and  V1ste,  1985;  S1lka  and
Wallen,  1988;  Wang  et al., 1985) and  In the  leachate  from  landfills  (Sabel
and Clark, 1984).
3.2.   FOOD
    Pertinent  data  regarding  human  exposure to ds-1,2-d1chloroethylene  In
food were not located 1n the available  literature  dted 1n Appendix A.
3.3.   INHALATION
    In  a  recent  compilation   and  analysis  of ambient  levels  of  volatile
organic  compounds  In the  atmosphere,  Shah  and Heyerdahl (1988)  determined
that the median dally urban level of ds-1,2-d1chloroethylene  was  0.050 ppb,
based  on  an analysis of 124  data points.   The levels were  below  the  limits
of  detection  1n  suburban or  rural areas.   Given  the above  value,  and  using
the average volume  of  air Inhaled  by  an  adult  human  (20  m3),  the  median
dally  Inhalation  Intake  of cls-1,2-d1chloroethylene by  the  urban  population
can be  calculated at 3.96  wg/day.   Since ds-1,2-d1chloroethylene  has  been
found  In  tap water,  human  exposure  may occur  by  Inhalation  of vapors  that
have volatilized  from the  water during  showers and other uses  of household
water.
                                /
3.4.   DERMAL
    Pertinent  data  regarding  dermal  exposure  to  ds-1,2-dlchloroethylene
were not  located  1n  the available  literature, dted  in Appendix  A.   Since
ds-l,2-d1chloroethylene has  been detected  1n  tap  water, 1t  Is likely  that
the  general  population  may  be  dermally  exposed   to   this  compound  while
showering or bathing with contaminated  water.
3.5.   OTHER
    Pertinent  data  regarding  other   routes  of  exposure  to ds-1,2-dlchloro-
ethylene were not located In the available literature cited 1n Appendix A.


0267d                               -11-                             12/19/89

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3.6.   SUMMARY
    ds-l,2-D1chloroethylene may  be released to  the  atmosphere  1n  emissions
from  Us  production and  use and  from  the volatilization  from  contaminated
wastewater  or  from waste disposal  sites,   ds-1,2-D1chloroethylene  may  also
be  released  to  the  environment  as  a result of the combustion of  poly(vlnyl)-
chloMde  polymers  or   as  a  result  of  the  biological   breakdown  of  other
chlorinated  solvents.
    Occupational  exposure  to ds-1,2-d1chloroethylene may  occur by  Inhala-
tion  or  dermal contact  during  Us manufacture,  transportation  or  use  as  a
solvent or  chemical  Intermediate.   Exposure by Inhalation  1s also  likely  1n
areas, such  as landfills, where ds-1,2-d1chloroethylene  1s  discarded.
    ds-1,2-01chloroethylene  has   been  detected  1n  surface  water,  ground-
water, rainwater  and drinking  water.   Consequently, exposure to  the  general
population  can  occur   by  drinking  contaminated water.   Since  ds-l,2-d1-
chloroethylene  has   been  detected  1n tap water,  exposure  to  the  general
population  may  occur   by  dermal  contact   or  Inhalation  while  bathing  or
showering.   ds-1,2-D1chloroethylene  has  also  been  detected 1n  urban air
samples.    Based  on  an analysis  of  urban air  levels  of  ds-1,2-d1chloro-
ethylene (Shah and Heyerdahl, 1988),  a median dally Inhalation Intake  can  be
calculated   as   3.96   pg/day.    Sufficient  data   are   not  available   to
accurately  estimate  human  exposure to  1,2-d1chloroethylene by other  routes
of exposure.
0267d                               -12-                             02/07/90

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                         4.  ENVIRONMENTAL TOXICOLOGY
4.1.   AQUATIC TOXICOLOGY
4.1.1.   Acute  Toxic  Effects  on  Fauna.   Pertinent   data   regarding  the
effects of  acute  exposure  of aquatic fauna  to  ds-1,2-d1ch1oroethylene were
not located 1n the available literature  cited 1n Appendix A.
4.1.2.   Chronic Effects on Fauna.
    4.1.2.1.   TOXICITY —  Pertinent data  regarding the  effects of  chronic
exposure  of  aquatic  fauna  to ds-1,2-d1chloroethylene  were  not located  1n
the available literature dted 1n Appendix A.
    4.1.2.2.   BIOACCUMULATION/BIOCONCENTRATION  — Pertinent   data  regarding
the  b1oaccumulat1on/b1oconcentrat1on  potential  of  cls-1,2-dlchloroethylene
In  aquatic   fauna  were  not  located  In  the available  literature  cited  1n
Appendix A.
4.1.3.   Effects on Flora.
    4.1.3.1.   TOXICITY —  Pertinent data  regarding  the  toxic  effects  of
exposure  of  aquatic  flora  to ds-1,2-dlchloroethylene  were  not located  In
the available literature cited 1n Appendix A.
    4.1.3.2.   BIOCONCENTRATION — Pertinent data   regarding  the bloconcen-
tratlon  potential   of ds-1,2-dlchloroethylene  In  aquatic   flora  were  not
located 1n the available literature dted In Appendix A.
4.1.4.   Effects  on  Bacteria.    Pertinent  data  regarding  the  effects  of
exposure of aquatic bacteria  to  ds-l,2-d1c:hloroethylene  were not located  In
the available literature dted In Appendix A.
4.2.   TERRESTRIAL TOXICOLOGY
4.2.1.   Effects  on   Fauna.   Pertinent   data   regarding  the   effects  of
exposure  of  terrestrial  fauna to ds-1,2-dlchloroethylene were  not  located
In the available literature dted 1n Appendix A.


0267d                               -13-                             12/19/89

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4.2.2.   Effects   on   Flora.    Pertinent  data  regarding   the   effects  of
exposure  of terrestrial  flora  to ds-l,2-d1chloroethylene  were  not located
In  the available literature cited In Appendix A.
4.3.   FIELD STUDIES
    Pertinent  data  regarding  the   effects   of  ds-1,2-d1chloroethylene  on
flora  and  fauna In  the field were  not  located In  the  available literature
cited  1n Appendix A.
4.4.   .AQUATIC RISK ASSESSMENT
    Pertinent data  regarding  the  effects  of  exposure of  freshwater fauna and
flora  to  ds-1,2-d1chloroethylene were not  located  In  the  available litera-
ture  cited In  Appendix A.   Acute  studies  with  representatives  from  eight
families  of freshwater  fauna and  at  least three  chronic  studies  and  one
bloconcentratlon study  with freshwater  fauna and  flora are  needed to develop
a freshwater criterion by the method of U.S.  EPA/OWRS (1986).
    Pertinent data regarding  the effects of  exposure  of  marine  fauna  and
flora  to  cls-1,2-d1chloroethylene were not  located  In  the  available litera-
ture  cited 1n  Appendix A.   Acute  studies  with  representatives  from  eight
families   of  marine  fauna  and   at   least   three  chronic   studies  and  one
bloconcentratlon study  with  marine fauna  and  flora  are needed  to develop a
saltwater  criterion by the method of U.S. EPA/OWRS (1986).
4.5.   SUMMARY
    Pertinent data  regarding  the  environmental  toxlclty of  ds-1,2-dlchloro-
ethylene were not located In the available literature cited   In Appendix A.
0267d                               -14-                             12/19/89

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                             5.  PHARMACOKINIETICS
5.1.   ABSORPTION
    Fllser  and  Bolt  (1979) exposed male  Wlstar  rats 1n a  closed  Inhalation
system to >500  ppm cls-1,2-d1chloroethylene and  monitored  the  decline  of  the
concentration 1n the gas phase  to  determine  the  equilibration  of atmospheric
cls-1,2-d1chloroethylene with  the  whole  body.   Concentrations  of cls-1,2-dl-
chloroethylene  In  the  system  declined  markedly  for  the  first 1.5  hours,
Indicating  rapid absorption.   Data were  not sufficient to  estimate  the rate
or extent of respiratory absorption.
    Pertinent  data   regarding   the  gastrointestinal  absorption  of  ds-1,2-
dlchloroethylene  were   not located  1n  the  available  literature  dted  In
Appendix A.  U.S. EPA  (1987a),  however,  noted that  the compound Is  neutral,
UpophlUc,  and has  low  molecular  weight.   Thus,  the chemical  should  be
readily absorbed by  any natural route of  exposure.
5.2.   DISTRIBUTION
    Pertinent   data   regarding   tissue   distribution  for   cls-1,2-d1chloro-
ethylene following Inhalation,  oral  or  dermal exposure of  animals or  humans
were not located  1n  the available literature dted  1n  Appendix  A.   U.S.  EPA
(1987a),  however, predicted that the highest  levels  of  the  compound  would be
located In  the  liver and kidney, assuming  this  compound behaves  similarly to
the structurally related 1,l-d1chloroethylene (McKenna  et  al.,  1978).
5.3.   METABOLISM
    Bonse et  al.  (1975) reported  that perfuslon  of the  Isolated rat  liver
with ds-1,2-dlchloroethylene  resulted  1n the production  of  dlchloroethanol
and dlchloroacetlc acid.   The  Initial  step 1n the metabolism  of ds-l,2-d1-
chloroethylene  may  Involve the formation of  chloroethylene   epoxlde,  which
undergoes   rearrangement   to   form  dlchloroacetaldehyde   (Henschler,   1977;
Lelbman and Ortiz,  1977).
0267d                               -15-                              02/07/90

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    According  to  Costa   and   Ivanetlch  (1982),  multiple  forms  of  hepatic
mlcrosomal  cytochrome P-450   bind  and metabolize  cls-1,2-dlchloroethylene.
These  Investigators  Identified 2,2-dlchloroethanol  and  dlchloroacetaldehyde
in  rat  hepatic  microsomes  Incubated  1n  the presence of  an NADPH-generatlng
system,  EDTA,  and  cls-1,2-d1chloroethylene.   2-Chloroethanol,  chloroacet-
aldehyde  or  chloroacetlc acid  were not produced  In significant amounts  In
these  Incubation  mixtures.   The Investigators  proposed  the metabolic scheme
presented  1n  Figure  5-1  and  Indicated  that the  nonenzymatlc  rearrangement
would be expected  to favor a chloride shift rather than a hydride shift.
    The   metabolic  elimination  of   Inhaled   cls-1,2-d1chloroethylene  was
examined  In male Wlstar   rats  exposed  In  a  closed  Inhalation  system (Fllser
and  Bolt,  1979).   Metabolic  elimination  was  described  as  a  saturable
phenomenon, changing from a first-order to a zero-order process at 20 ppm.
    Fllser  and  Bolt  (1980)  detected  acetone  1n  the  expired  air  from male
Wlstar  rats  exposed  1n  a  closed  Inhalation   system   to  cls-1,2-dlchloro-
ethylene.   The  Investigators  postulated   that  metabolites  of  ds-l,2-d1-
chloroethylene  may Inhibit  enzymes  of  the  citric  add  cycle, resulting  In
acetonemla  and   the  exhalation of  acetone.  Acetone  was  not considered  a
metabolite of  ds-1,2-d1chloroethylene.
5.4.   EXCRETION
    Pertinent   data   regarding  the  excretion   of  ds-1,2-dlchloroethylene
following  Inhalation,  oral  or  dermal exposure of animals  or  humans were not
located 1n the available  literature cited  In Appendix A.
5.5.   SUMMARY
    Pharmacoklnetlc  data  for  c1s-l,2-dlchloroethylene   are  limited.    Gas
uptake  studies  in rats  Indicated  that ds-1,2-dlchloroethylene  Is absorbed
readily  from  the  respiratory  tract  (Fllser  and  Bolt,  1979).   Because  the
0267d                               -16-                             12/19/89

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C IHC-CHC
     / \
C I HC—CHC I
                                                      I«• Shift
                                  non-*nz ymIc
                                 r«orrong«minI
             HjO
C I H2CCOCI  —* C I H2CC02H
                                          •*	C h I » r I d •  i h I H
                                  CIjHCCHO —- C IjHCCOjH
                                       I
                                  C 12 H C C H 2 0 H
                                    FIGURE 5-1
                Proposed Metabolic  Scheme for the 1,2-01chloroethylenes
                         Source:  Costa and Ivanetlch,  1982
     0267d
                   -17-
                    12/19/89

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compound  1s  neutral,  UpophlUc,   and   has   low  molecular  weight,  H  Is
expected  to  be  readily absorbed by any  natural  route  of  exposure (U.S.  EPA,
1987a).   Although  tissue  distribution  data  were not  located,  the  highest
tissue  levels would be expected 1n the  liver  and  kidneys  (U.S. EPA,  1987a),
If  this  compound behaves similarly to 1,l-d1chloroethylene  (McKenna  et  al.,
1978).
    ds-1,2-D1chloroethylene  Is  metabolized  by  hepatic  cytochrome  P-450
oxIdasBs,  with  the  formation  of  dlchloroacetaldehyde  and  dlchloroethanol
(Costa  and  Ivanetlch, 1982).   The  Initial step  1n  the metabolism  probably
Involves  formation  of a chloroethylene  epoxlde  that  undergoes  rearrangement
to   dlchloroacetaldehyde  (Henschler,   1977;   Lelbman   and  Ortiz,   1977).
Metabolic elimination  of ds-1,2-d1chloroethylene was described  as  a satur-
able  process, changing from  a first-order to  a  zero-order  process at 20 ppm
(Fllser and Bolt, 1979).
    Pertinent  data   regarding   the  excretion  of  ds-1,2-d1chloroethylene
following  oral,   Inhalation   or  dermal  exposure  were  not  located  In  the
available literature cited 1n Appendix A.
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                                 6.  EFFECTS
6.1.   SYSTEMIC TOXICITY
6.1.1.   Inhalation Exposure.
    6.1.1.1.   ACUTE — In    an   unpublished   study,   Smyth    (1937-1955)
determined  that  8000  ppm  ds-1,2-dlchloroethylene was  not  lethal  to rats
exposed for 4  hours.   However,  rats  were anesthetized In 8 minutes and died
within 4  hours  after  exposure to  16,000  ppm.   Narcosis  1s  a primary  effect
1n  animals   exposed   to   ds-1,2-d1chloroethylene  by  Inhalation  (Smyth,
1937-1955).   ds-l,2-01chloroethylene   also  produces  narcosis  1n   humans
exposed to high concentrations  of  this  chemical  (ACGIH, 1986).
    Freundt and Macholz (1978)  showed  that  a single 8-hour  Inhalation expo-
sure  to 200,  600  or 1000  ppm  ds-1,2-dlchloroethylene  resulted 1n signifi-
cant,   dose-dependent  Increases In hexobart>1tal  sleeping  time,  zoxazolamlne
paralysis  times and the metabolic  formation of 4-am1noant1pyr1ne  from  amlno-
pyrlne 1n  adult female Wlstar rats.   These  Increases Indicated  an   Inter-
action with the mixed-function  oxldase  system,
    6.1.1.2.   SUBCHRONIC  --  Pertinent   data   regarding   the   toxkHy   of
ds-1,2-d1chloroethylene following subchronlc Inhalation exposure of animals
or humans  were not  located  1n  the  available  literature  dted  1n  Appendix A.
    6.1.1.3.   CHRONIC  --  Pertinent data regarding  the  toxldty of ds-1,2-
dlchloroethylene following chronic  Inhalation  exposure of  animals or  humans
were not  located 1n the available  literature dted  1n  Appendix A.
6.1.2.   Oral  Exposure.
    6.1.2.1.   SUBCHRONIC  --  Pertinent   data   regarding   the   toxldty   of
cls-1,2-dlchloroethylene following  subchronlc  oral  exposure of  animals  or
humans were not located 1n  the  available literature dted 1n  Appendix A.
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    6.1.2.2.   CHRONIC -- Pertinent data  regarding  the toxldty  of  ds-1,2-
dlchloroethylene  following  chronic oral  exposure  of animals or  humans  were
not located In the available literature dted 1n Appendix A.
6.1.3.   Other  Relevant  Information.   Quast  et  al.  (1983)   administered
1,l-d1chloroethylene,  an  Isomer  of   ds-1,2-d1chloroethylene,   1n  drinking
water to Sprague-Dawley  rats for  2 years  at concentrations  of 0, 50, 100 and
200  ppm.   Experimental   groups  were  composed  of  48  rats/sex,  while  80
rats/sex formed  the control group.   Adjusted doses for  continuous  exposure
were estimated by  the  Investigators at 0,  7,  10 or  20 mg/kg/day 1n males and
0,  9,   14  or  30  mg/kg/day   In  females.   No  statistically  significant
differences between  treated  and control groups were  seen  regarding  survival
time,   body   weight,  food  and   water   consumption,   hematology,   clinical
chemistry,  urlnalysls  and gross  pathology.   Furthermore,  the  authors  could
not  establish a  relationship  between  exposure  to  1 ,l-d1chloroethylene  and
neoplastlc changes.   Females In  all  treated groups,  however,  and  males  1n
the   highest   dose   group   developed   hepatic   lesions   described    as
"hepatocellular swelling  with  mldzonal fatty  change."  Acute  LD5Q  data  for
ds-1,2-dlchloroethylene  have   not been  reported.   Jenkins et  al.  (1972)
evaluated the hepatotoxlclty of  ds-1,2-dlchloroethylene  1n rats.  Groups  of
three or four adult Holtzman rats  were given ds-1,2-dlchloroethylene  as  a
single   dose  of   either  400   or   1500   mg/kg^  by   gavage  In   corn   oil.
ds-1,2-D1chloroethylene  significantly   elevated   the  activity  of   liver
alkaline phosphatase at   the  400  and  1500 mg/kg  doses.   The  activities  of
liver glucose-6-phosphatase, liver  tyroslne transamlnase and plasma alanlne
transamlnase decreased at the 1500 mg/kg  dose.   It  should  also  be noted  that
although there  1s  little data  to Implicate  ds-1,2-dlchloroethylene  as  a
neurotoxlcant, 1t  1s  structurally  similar to  trlchloroethylene which   Is  a
neurotoxlc  agent.

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6.2.   CARCINOGENICITY
6.2.1.   Inhalation.    Pertinent  data  regarding   the   cardnogenldty   of
ds-l,2-d1chloroethylene  following Inhalation exposure of  humans  or animals
were not located 1n the available  literature  cited 1n Appendix A.
6.2.2.   Oral.   Pertinent data regarding the cardnogenldty of  ds-l,2-d1-
chloroethylene  following  oral  exposure of  humans or  animals were not located
In the available literature  dted  1n Appendix A.
6.2.3.   Other   Relevant  Information.   Other  relevant  Information  regarding
the  cardnogenldty   of  ds-1,2-d1chloroethylene were  not  located 1n  the
available literature  dted  1n  Appendix A.
6.3.   GENOTOXICITY
    Relevant genotoxldty data for ds-l,2-d1chloroethylene are presented In
Table 6-1.  The pattern  1s  predominantly negative  1n  prokaryotes  and weakly
positive  1n  eukaryotes.    In  In  vitro  studies   1n  prokaryotes,  neither
ds-1,2-d1chloroethylene  alone  (Cerna  and  Kypenova, 1977) nor  In  a mixture
with  the  trans- Isomer  (Mortelmans  et al.,,  1986)  Induced reverse mutations
with  or  without  metabolic  activation  1n  Salmonella  typhlmurlum.  In  the
absence of activation, neither forward nor  reverse mutations  were Induced In
Escherkhla coll  K12  (Grelm  et  al.,  1975);  however,  Cerna   and  Kypenova
(1977) reported positive  results with S. typhlmurlum using the host-mediated
assay 1n  female  ICR  mice.   In  liquid  suspensions of  strain  07 of Saccharo-
                                              ^                     _«M.^^^^—
myces cerevlslae. ds-l,2-d1chloroethylene Induced  a  slight  but significant
dose-related Increase  In  ade~  recomblnants  1n  the  presence  of  metabolic
activation but  only  at  one concentration  In the absence of  activation.   In
the  same  system,  an  Increase In 1lv*  reverse   point mutations  was Induced
at one  concentration  1n  the absence of activation  (Bronzettl  et  al.,  1984;
Gain et  al.,  1982).  The  compound  had sporadic  effects on  the  number of


0267d                              -21-                             07/25/90

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                                                                                TABLE 6-1

                                                            Genotoxlclty Testing of cls-1,2-D1chloroethylene
I
rv>
l\3
i
Assay
Reverse
nutation



Forward
mutation
Nilotic
recombination
Indicator
Organism
Salmonella
typhlmurlum
TA1535. TA1537,
TA98. TA100
S. typhlmurlum
TA9B. TA100.
TA1535. TA1538.
TA1950, TA1951.
TA1952
S. typhlmurlum
TA1950. TA1951.
TA1952
Escherlchla coll
K12 (gal*, arg*.
nad*)
E. coll K12
(5-methyl
tryptophan
resistance)
Saccharomyces
cerevlslae 07
Application
liquid
suspension
spot test
host-mediated
assay In female
ICR mice
liquid
suspension
liquid
suspension
liquid
suspension
Purity
(X)
els-trans
mixture
NR
NR
analytical
grade
analytical
grade
97
Concentration
or Dose
33.3-3333.3
tig/plate
0.5. 5. 50
rag/plate
0.5. 1 time
L050
2.9 mM
2.9 mM
40. 80. 100 mM
Activating
System
+/- rat and
hamster liver
S9

NA
+/- mouse liver
mlcrosomal pro-
tein and NADH
generating
system
*/- mouse liver
mlcrosomal pro-
tein and NAOH
generating
system
»/- mouse liver
mlcrosomal pro-
Response Comment
-/- NC
Applied 0.05 ml of 1.
10. 100X per plate
« Dose-effect relation-
ship reported
NC
NC
+/(*) Dose-dependent toxlclty
with lower survival
Reference
Mortelmans
et al.. 1986
Cerna and
Kypenova. 1977
Cerna and
Kypenova. 1977
Grelm et al. ,
1975
Grelm et al..
1975
Gall et al..
1982; Bronzettl
                                                                                            teln and NADH
                                                                                            generating
with S9; dose-dependent
production of ade*
recomblnants with S9
and at 100 mM without
S9; llv* revertants
at 100 mM without S9
et al.. 1984
03
O

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                                                                                 6-1 (cont.)
Assay
Gene
conversion


Indicator Application
Organism
S. cerevlslae 07 liquid
suspension


Purity Concentration Activating
(X) or Dose System
97 40. 80. 100 nfl »/- mouse liver
mlcrosomal pro-
tein and NADH
generating


Response Comment
-/- Dose-dependent toxldty
with lower survival
with S9; dose-dependent
production of ade*
recomblnants with S9
and at 100 mH without
S9; llv* revertants
at 100 mH without S9
Reference
Gall
1982;
et al


et al..
Bronzettl
.. 1984


     Point
     mutation
S. cerevlslae 07   liquid
                   suspension
                                                                97
                                 40.  80.  100 nfl
     Gene
     conversion
S. cerevlslae 07
CO
i
     Point
     mutation
S. cerevlslae 07
o   Sister
^   chromatld
•M   exchange
\   	
o
                     Chinese hamster
                     fIbroblasts
                  »/- mouse liver
                  mlcrosomal pro-
                  tein and NADH
                  generating
Intrasangulneous
hose-mediated
assay In male
Swiss albino mice
by gavage
                                                                97
1300 mg/kg once   NA
Intrasangulneous
hose-mediated
assay In male
Swiss albino mice
by gavage
                                                                97
300 mg/kg/day.
8 days «• 600
mg/kg 9th day
NA
                   cell culture
                                                                97
                                 0.25-2 mg/mt
                  rat liver  S9.
                  NADP
                                                                                                              -/(*)      Dose-dependent  toxldty
                                                                                                                        with lower survival
                                                                                                                        with S9;  dose-dependent
                                                                                                                        production of ade*
                                                                                                                        recomblnants with S9
                                                                                                                        and at  100 mH without
                                                                                                                        S9; llv*  revertants
                                                                                                                        at 100  mH without S9

                                                                                                               (»)       In acute  tests,  trp*
                                                                                                                        convertants In  liver,
                                                                                                                        not kidney or lung,
                                                                                                                        and llv*  revertants  In
                                                                                                                        kidney, not liver or
                                                                                                                        lung: with repeated
                                                                                                                        dosing, convertants  In
                                                                                                                        lung,  liver or  kidney
                                                                                                                        and revertants  In kidney
                                                                                                                        and lung,  not liver

                                                                                                               (»)       In acute  tests,  trp*
                                                                                                                        convertants In  liver,
                                                                                                                        not kidney or lung,
                                                                                                                        and llv*  revertants  In
                                                                                                                        kidney, not liver or
                                                                                                                        lung; with repeated
                                                                                                                        dosing, convertants  In
                                                                                                                        lung,  liver or  kidney
                                                                                                                        and revertants  In kidney
                                                                                                                        and lung,  not liver
                                                                                                   NC
                                                        Gall  et al..
                                                        1982;  Bronzettl
                                                        et  al.. 1984
                                                        Bronzettl
                                                        et  al..  1984
Bronzettl
et al.. 1984
                                                        Sawada  et  al.,
                                                        1987

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                                                                            TABLE 6-1 (cont.)
o
rvi
cr>
Assay
Chromosomal
aberrations

Indicator
Organism
Chinese hamster
flbroblasts
female ICR mice
Application
cell culture
Intraperltoneal
Injection
Purity
(X)
97
NR
Concentration
or Dose
0.25-2 mg/mi
0.5 x LOso.
single dose
Activating
System
rat liver S9.
NADP
NA
Response
NC
Comment

No significant differ-
ence with a single dose
Reference
Sawada et al..
1987
Cerna and
Kypenova. 1977
                      female ICR mice
Intraperltoneal
Injection
NR
0.167 x LD5o.
5-10 times
dally
NA
but Increased cells
with aberrations with
5 dally doses; dose-
dependence seen 6 hours
after 10th dose

No significant differ-
ence with a single dose
but Increased cells
with aberrations with
5 dally doses; dose-
dependence seen 6 hours
after 10th dose
Cerna and
Kypenova. 1977
       NA  •= Not applicable; NC « no comment; NR • not reported; ( + ) •= weakly positive
 in
 ^

 O

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trpf  convertants  and  11vf reverse  point mutations  1n yeast  of  the  same
strain recovered  from various organs  In an  Intrasangulneous  host-mediated
assay  (Bronzettl  et  al..  1984).    In   the  one  mammalian In  vitro  assay
located,  ds-1,2-dlchloroethylene did not  Induce  chromosomal  aberrations  or
sister chromatld exchanges 1n Chinese hamster  cells  In  vivo (Sawada et al.,
.1987).  Ln  vivo.  H  Induced  chromosomal  aberrations 1n the bone marrow  of
IntraperHoneally  Injected mice (Cerna and Kypenova,  1977).
6.4.   DEVELOPMENTAL TOXICITY
    Pertinent data  regarding  the teratogenldty of  ds-l,2-d1chloroethylene
were not  located In  the  available literature cited  1n Appendix A.
6.5.   OTHER REPRODUCTIVE  EFFECTS
    Pertinent data regarding other reproductive effects of cls-1,2-dlchloro-
ethylene  were not  located  In  the  available literature cited In Appendix A.
6.6.   SUMMARY
    Acute Inhalation exposure of  animals or  humans to high concentrations  of
ds-l,2-d1chloroethylene vapors  can  produce anesthesia  and narcosis (Smyth,
1937-1955;  ACGIH,  1986).   In  rats,  exposure  to 16,000 ppm ds-1,2-dlchloro-
ethylene  for 4 hours resulted  1n  death (Smyth,  1937-1955).
The  results  of  an  acute  oral toxlclty study  1n  rats  provided  biochemical
evidence   that  ds-l,2-d1chloroethylene  Is   hepatotoxlc   (Jenkins  et  al.,
1972).   ds-l,2-D1chloroethylene  significantly  elevated  the  activity  of
liver  alkaline  phosphatase  at   the  400  and  1500 mg/kg  dose  levels.   The
activities   of  liver glucose-6-phosphatase,  liver  tyroslne transamlnase and
plasma alanlne transamlnase decreased at the 1500  mg/kg  dose level.
    The systemic  toxldty resulting from subchronlc or  chronic exposure  to
ds-1,2-d1chloroethylene,  either by  Inhalation or oral  administration, has
0267d                               -25-                             07/25/90

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not been examined.  It should be  noted  that  although  there  Is  Uttle  data  to
Implicate  ds-l,2-d1chloroethylene  as  a  neurotoxlcant,  1t  1s  structurally
similar to trlchloroethylene which 1s  a  neurotoxlc  agent.
    Pertinent  data  regarding   the .< carclnogenlcHy  or  teratogenldty   of
cls-1,2-d1chloroethylene to  animals  or  humans exposed  by any  route  to  this
chemical were  not  located  1n the  available  literature  cited In Appendix  A.
ds-1,2-D1chloroethylene yielded  a  positive  result In a host-mediated assay
using S. cerlvlslae D7  strains  In mice  (Bronzettl  et al., 1984) but  did not
cause  chromosomal   aberrations   or  sister  chromatld  exchanges  In  Chinese
hamster cells in vitro (Sawada et al., 1987).
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                     7.   EXISTING  GUIDELINES AND  STANDARDS
7.1.   HUMAN
    ACGIH  (1989) has  not  adopted  TLVs  for  ds-1,2-d1chloroethylene;  however,
the currently recommended TWA-TLV for  the  commercial mixture  of  the  ds- and
trans-lsomers  Is  200 ppm  (790 mg/m3),  based  on a  no-effect level  of  1000
ppm  1n  animals  (ACGIH,  1986).   Because  the  no-effect  level for  prolonged
animal Inhalation 1s -1000 ppm, ACGIH  (1986) regards the  TLV  as  sufficiently
conservative  and  does not  recommend  a  STEL  for  the  mixture.  OSHA  (1989)
also  does  not 11st  a  value for  cls-1,2-dlchloroethylene  but lists  transi-
tional  and final  rule   limits  of  200 ppm (790 mg/m3)  for   the  commercial
mixture, which Is  Identical  to the  ACGIH  (1989) recommendation.   The  1-day,
10-day,   longer-term  and  lifetime   HAs   recommended  for   cls-1,2-dlchloro-
ethylene by  U.S.  EPA (1987a)  were  4, 1,  1  and 0.07  mg/l (child),  respec-
tively.   The  longer-term  HA  for  an  adult  was  3.5  mg/l.   Only  the  1-day
advisory was  computed from  data  generated by  exposure to  cls-1,2-dlchloro-
ethylene;  the  other  values  were derived  from experiments with 1,1-dlchloro-
ethylene.
7.2.   AQUATIC
    Guidelines  and  standards   to  protect aquatic  life  from  exposure  to
ds-1,2-d1chloroethylene  were  not  located  lin  the available literature  cited
1n Appendix A.
0267d                               -27-                             02/07/90

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                              8.   RISK  ASSESSMENT
8.1.   CARCINOGENICITY
8.1.1.   Inhalation.   Pertinent   data  regarding  the  cardnogenldty   of
Inhalation  exposure  of  humans  or animals  to cls-1,2-dlchloroethylene  were
not located 1n the available literature cited In  Appendix A.
8.1.2.   Oral.   Pertinent  data   regarding   the   cardnogenldty   of  oral
exposure of  humans or animals  to ds-l,2-d1chloroethylene were not  located
In the available literature dted 1n  Appendix A.
8.1.3.   Other  Routes.   Pertinent  data  regarding  the   cardnogenldty   of
ds-1,2-d1chloroethylene  to  humans  or animals exposed  by other routes  were
not located 1n the available literature cited 1n  Appendix A.
8.1.4.   Weight of  Evidence.   Because data  were  not  located  regarding  the
cardnogenldty  of ds-1,2-dlchloroethylene  In   humans  or  In  animals,  the
compound Is  most  appropriately placed  1n  U.S.  EPA we1ght-of-evldence  Group
D:  not classifiable as to human cardnogenldty  (U.S.  EPA,  1986b).
8.1.5.   Quantitative Risk Estimates.  The absence  of  cancer data by  either
the Inhalation or  oral  routes  precludes  derivation of potency  slope  factors
for either  route of exposure.
8.2.   SYSTEMIC TOXICITY
8.2.1.   Inhalation Exposure.
    8.2.1.1.   LESS THAN  LIFETIME (SUBCHRONIC) ~  Pertinent  data regarding
the  toxlclty  of subchronlc  Inhalation exposure   to  ds-1,2-dlchloroethylene
were  not   located  1n  the  available   literature  cited  In  Appendix  A.   As
discussed   In  Section 8.2.2.2.,  1n the  absence of chemical-specific data,  it
Is  appropriate to  consider  deriving an  RfD  for  ds-1,2-dlchloroethylene
based on analogy to 1,1-dlchloroethylene.  Inhalation data  for  1,1-dlchloro-
ethylene abound and  have been reviewed by U.S.  EPA (1986c),  but no RfD  has

0267d                              -28-                             12/19/89

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been  derived  for  Inhalation  exposure.    It  Is  beyond  the  scope  of  this
document  to  evaluate  the data on  1,1-dkhloroethylene  to derive RfD  values
for  Inhalation  exposure to  that  chemical.   Therefore,  1t  Is not  currently
possible  to  derive an  RfD  for subchronlc Inhalation exposure to  ds-l,2-d1-
chloroethylene by analogy to 1,1-dlchloroethylene.
    8.2.1.2.   CHRONIC — Pertinent   data   regarding    chronic    Inhalation
exposures  to  cls-1,2-dlchloroethylene  were  not  located 1n  the  available
literature  dted  1n  Appendix A.   As  discussed  above,  1t Is appropriate  to
consider  deriving  an  RfD  for ds-1,2-d1chloroethylene  based  on analogy  to
1,1-dlchloroethylene.    The  lack  of an RfD  for  chronic  Inhalation  exposures
to  1,1-dlchloroethylene,  however,  precludes   derivation  of  an   RfD   for
c1s-l,2-d1chloroethylene by analogy to 1 ,l-d1chloroethylene.
8.2.2.   Oral Exposure.
    8.2.2.1.   LESS THAN  LIFETIME  (SUBCHRONIC)  —  Pertinent  data  regarding
the  toxldty  of subchronlc  oral  exposures  to ds-1,2-dlchloroethylene  were
not  located 1n  the  available  literature, cited  In Appendix  A.   Chemical-
specific  data  are not  sufficient for derivation  of an RfD for  subchronlc
oral exposures  to ds-1,2-dlchloroethylene.  Therefore,  the chronic  oral  RfD
of  0.009  mg/kg/day  derived   by 'analogy   to  1,l-d1chloroethylene  In  Section
8.2.2.2.  Is  adopted  as the  RfD  for  subchronlc  oral exposure to  ds-l,2-dl-
chloroethylene.  Confidence  In  the key  study  Is medium;  confidence  in  the
data base and RfD are low,  as explained 1n Section  8.2.2.2.
    8.2.2.2.   CHRONIC — Pertinent data  regarding  chronic  oral  exposures
to  ds-1,2-dlchloroethylene   were  not located  in   the   available  literature
dted In  Appendix A.   Because chemical-specific  data are not sufficient  for
derivation of an RfD,  It 1s  appropriate  to consider  data from chemicals  that
are   structurally   and   tox1colog1cally  similar.    Structurally   similar


0267d                               -29-                              12/19/89

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 chemicals  that  could  be  considered Include  trans-1,2-d1chloroethylene and
 I,l-d1chloroethylene.   U.S.  EPA (1989)  derived  an oral chronic  RfD  of 0.02
 mg/kg/day  for  trans-1,2-d1chloroethylene  from  a  subchronlc  drinking  water
 rat  study  and  an  RfD  of  0.009  mg/kg/day  for  1 ,l-d1chloroethylene.   In
 deriving  lifetime HAs  for  els- and  trans-1,2-d1chloroethylene  (see  Section
 7.1.).  U.S.  EPA  (1987a,b)  evaluated data for  1,1-,  ds-1,2- and trans-1,2-
 dlchloroethylene  and  concluded that  the noncardnogenlc  effects of  these
 compounds  are essentially  Identical.  Pharmacok1net1c  data  for  the 1,1- and
 l,2-1somers  (U.S. EPA,  1986c)  Indicate that  the metabolism  of all  three
 Isomers  Is similar  and  Involves the  formation  of an  epoxlde Intermediate.
 Additionally,,  the  proposed  metabolism  scheme  for  1,2-d1chloroethylene  by
 Costa and  Ivanetlch  (1982)  postulates  that  a chloride shift  would be favored
 to  the  exclusion  of  a hydride  shift  (see  Section  5.3.).   U.S. EPA (1987a,b)
 determined that  the  most conservative  approach  was to base derivation of the
 lifetime  has  for the  c1s-l,2-1somer  on  analogy  to  1,l-d1chloroethylene,
 which   seems   to  follow   a   metabolic   pathway  very   similar   to   the
 cls-1,2-1somer.   Pursuing  the  precedent  of  U.S. EPA  (1987a,b),  the verified
 RfD  of  0.009  mg/kg/day for  chronic  oral exposure  to  1,1-dlchloroethylene  Is
 adopted  as the  RfD  for chronic  oral  exposure  to cls-1,2-d1chloroethylene.
 The  RfD of 0.009  mg/kg/day was based  on a  LOAEL of 9 mg/kg/day  for  liver
 effects  In a  2-year  drinking  water study  using rats (Quast  et  al.,  1983).
 As stated  by  U.S.  EPA  (1989),  confidence 1n the study 1s  medium.   Confidence
 In  the  data   base  for  mixed 1,2-d1chloroethylene  Is  low; confidence  In the
 RfD  Is  low because  of  the  additional  uncertainty associated  with basing  an
 RfD  on   analogy   to  a  similar   chemical.   NTP   (1989)   Indicated   that
 ds-1,2-dlchloroethylene has   been   selected  for  toxldty  testing.   These
 tests,  when completed, may  permit derivation of chemical-specific  RfD values.


0267d                               -30-                              02/07/90

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                           9.   REPORTABLE QUANTITIES
9.1.   BASED ON SYSTEMIC TOXICITY
    The  toxldty  of cls-1,2-d1chloroethylene was  reviewed and  evaluated  1n
Chapter  6.    Pertinent   data   regarding   systemic   toxldty   consequent   to
subchronlc or  chronic exposure  to  ds-1,2-d'ichloroethylene  by  either  oral  or
Inhalation exposure  of  humans  or  animals  were  not located 1n  the  available
literature cited 1n Appendix A.  Therefore,  an  RQ  cannot  be derived for  this
compound  from chemical-specific  data.   An  RQ  of  1000,   however,  has  been
derived  by U.S.  EPA (1986c)  for   the  other two  dlchloroethylene  Isomers,
trans-1,2-d1chloroethylene and  1,l-d1chloroethylene.   The  former  represents
a  CS  of   13.8,  based   on  fat  accumulation   1n  the  liver  and  hlstologlcal
alterations    1n    the    lungs    of   six    rats    exposed    to    200    ppm
trans-1,2-d1chloroethylene 8 hours/day, 5  days/week for 16  weeks  (Freundt  et
a!., 1977).   The  latter represents a CS of  19.0,  based on early  deaths  and
terminations   among  12  mice   exposed  to  55  ppm  1,l-d1chloroethylene   6
hours/day,  5  days/week   for  10 months  with  12 months  observation  (Hong  et
al.,   1981).    As   discussed   In   Chapter  8,    1t   Is  appropriate,   when
chemical-specific data  are lacking, to derive  risk assessment  values  based
on analogy to a chemical  that  Is  structurally  and  lexicologically similar.
To  maintain  consistency with  the  approach  used   1n  Chapter   8,  the RQ  for
mixed  1,2-d1chloroethylene  Isomers   will  be   based  by  analogy  on   the
1,1-lsomer.   Moreover,   the  key  study  for  the l,l-1somer  Is  of  a  higher
quality,  since  H  uses  more animals and   Is  of longer  duration.   Therefore,
an RQ  of  1000 Is recommended for  cls-1,2-d'ichloroethylene, based  on  analogy
to I,l-d1chloroethylene  (Table  9-1).
0267d                               -31-                             02/07/90

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                                   TABLE  9-1
                           ds-1,2-D1chloroethylene
           Minimum Effective  Dose  (MED) and  Reportable  Quantity  (RQ)


Route:                  Inhalation
Species/Sex:            mice/male, female
Dose*:                  259 mg/day
Duration:               10 months  (with 12 months observation)
Effect:                 postexposure mortality and morlbundlty
RVd:                    1.9
RVe:                    10
CS:                     19.0
RQ:                     1000
Reference:              Hong et al., 1981

*Equ1valent human dose
0267d                               -32-                             12/19/89

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9.2.   BASED ON  CARCINOGENICITY
    Pertinent data regarding the cardnogenlcHy of  ds-1,2-d1chloroethylene
In  humans or  In  animals  were not located In the available  literature dted
In  Appendix  A.    Therefore,  cis-1,2-dkhloroethylene  Is  most  appropriately
placed 1n U.S. EPA we1ght-of-ev1dence Group D:  not  classifiable as  to human
cardnogenlcHy   (U.S.  EPA,  1986b).   No  hazard  ranking   1s   assigned   to
chemicals In  Group  0;  therefore, an  RQ  based  on cardnogenlcHy cannot  be
assigned.
0267d                              -33-                             12/19/89

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0267d                               -34-                             02/07/90

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0267d                               -35-                             12/19/89

-------
Crockett,  P.M.,  B.  Klllan,  K.S.  Crump  and  R.B.  Howe.   1985.   Descriptive
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Elsenrelch,  S.J.,  B.B.  Looney and J.D.  Thornton.  1981.   Airborne  organic
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Fllser,   J.G.  and   H.M.  Bolt.    1979.    Pharmacok1net1cs   of   halogenated
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0267d                               -36-                             02/07/90

-------
Fllser, J.G.  and  H.M.  Bolt.  1980.  Characteristics of  haloethylene-lnduced
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0267d                               -37-                             02/07/90

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0267d                               -38-                             02/07/90

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Jaber, H.M., U.R. Mabey,  A.T.  L1u,  T.W.  Chou and H.L. Johnson.  1984.   Data
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Jenkins,   L.J., Jr.,  M.J.  Trabulus  and   S.D.  Murphy.   1972.   Biochemical
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chloMde and 1,2-dkhloroethylene.   Toxlcol.  Appl. Pharmacol.   23: 501-510.

Kawamura, K. and  I.R.  Kaplan.   1983.   Organic compounds  In  the  rainwater of
Los Angeles.  Environ.  Scl.  Technol.   17:  497-501.

Krlll, R.M.  and W.C.  Sonzognl.   1986.   Chemical monitoring of Wisconsin's
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Lelbman,   K.C.  and  E.  Ortiz.   1977.   Metabolism of  halogenated ethylenes.
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Lyman, W.J.    1982.   Adsorption  coefficient  for  soils  and  sediments.    Jru
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Mabey, W.R.,  J.H.  Smith,  R.T.  Podoll,  et  al.   1981.  Aquatic  Fate  Process
Data for  Organic Priority Pollutants.  U.S.  Environmental  Protection  Agency,
Washington, DC.  EPA-440/4-81-014.   p.  159-160.
0267d                               -39-                             07/25/90

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Mantel,  N.  and  M.A.   Schnelderman.   1975.   Estimating  "safe"  levels,  a
hazardous undertaking.   Cancer Res.  35:  1379-1386.

McKenna,  M.J.,  J.A.   Zempel,  E.O.  Madrid  and  P.J.  Gehrlng.   1978.   The
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MUhal,  J.   1976.  ToxUHy  of  pyrolysls and combustion  products of poly-
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Mortelmans,  K.,  S. Haworth,  T.  Lawlor,  W. Speck, B.  Talner  and  E.  Zelger.
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N1k1,  H.,  P.O.  Maker,  C.M.  Savage  and L.P. Breltenbach.   1983.   Atmospheric
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NIOSH  (National  Institute  for   Occupational   Safety   and Health).   1989.
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Parsons,  F.,  P.R. Wood  and  J.  DeMarco.   1984.   Transformations  of  tetra-
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56-59.
0267d                               -40-                              07/25/90

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Quast, J.P., C.G.  Humlston, C.E.  Wade, et al.  1983.  A chronic toxldty and
oncogenkHy study In rats and subchronlc toxldty study 1n dogs on Ingested
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Sabel, G.V. and T.P.  Clark.  1984.   Volatile organic compounds as Indicators
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0267d                               -41-                             07/25/90

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Suffet,  I.H.,  L.  Brenner and  P.R.  Cairo.   1980.   Gas  chromatography-mass
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0267d                               -42-                             07/25/90

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Thomas,  R.G.   1982.   Volatilization  from water.   In_:  Handbook of  Chemical
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Health  Effect  Assessment  Chapters  of  the  Consent  Decree  Hater  Criteria
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Assessment, Environmental Criteria and Assessment  Office, Cincinnati,  OH  for
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0267d                               -43-                             07/25^90

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U.S.  EPA.   1987a.   Health  Advisory  Document  for  cls-1,2-D1chloroethylene.
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U.S.  EPA.   1987b.   Health Advisory Document  for trans-l,2-01chloroethylene.
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U.S.  EPA.   1989.   Integrated  Risk   Information  System  (IRIS).   Online.
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Water  Quality  Criteria  for  the  Protection  of  Aquatic  Organisms and  Their
Uses.  U.S. EPA, Washington,  DC.  p. 22-58,  98.   PB85-227049/XAB.

Wang, T.C.,  R.  Lenahan,  M.  Kanlck, et al.   1985.   The  removal  of trkhloro-
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Contam. ToxUol.  14: 719-723.

Weast, R.C.,  M.J.  Astle and W.H.  Beyer..   1988.  CRC Handbook of Chemistry
and Physics,  69th ed.  CRC Press, Inc.,  Boca Raton,  PL.   p.  C-272.
0267d                               -44-                             07/25/90

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Westrlck, J.J.,  J.W.  Hello  and R.F.  Thomas.   1984.   The groundwater  supply
survey.  J.  Am. Water Works  Assoc.   76:  52-59.

Wilson,  B.H.,  G.B.   Smith   and  J.F.  Rees.    1986.    Blotransformatlon  .of
selected aklylbenzenes and  halgenated aliphatic  hydrocarbons  In  methanogenlc
aqulfler material:  A  microcosm study.   Environ.  Scl.  Technol.   20:  997-1002.

Wlndholz, M.,  Ed.,  et al.   1983.   The  Merck  Index.   Merck and  Co.,  Rahway,
NJ.  p. 13-14.
0267d                               -45-                             07/25/90

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                                  APPENDIX A

                              LITERATURE  SEARCHED



    This  HEED  1s  based  on  data  Identified  by  computerized  literature

searches of the following:


              CHEMLINE
              TSCATS
              CASR online (U.S. EPA Chemical Activities Status Report)
              TOXLINE
              TOXLIT
              TOXLIT 65
              RTECS
              OHM TADS
              STORET
              SRC Environmental Fate Data Bases
              SANSS
            .  AQUIRE
              TSCAPP
              NTIS
              Federal Register
              CAS ONLINE (Chemistry and Aquatic)
              HSDB
              SCISEARCH
              Federal Research in Progress


These  searches  were  conducted in  July,  1989,  and  the  following  secondary

sources were reviewed:
    ACGIH  (American  Conference of  Governmental  Industrial  Hygienists).
    1986.   Documentation  of the  Threshold  Limit Values  and  Biological
    Exposure Indices, 5th ed.  Cincinnati, OH.

    ACGIH  (American  Conference of  Governmental  Industrial  Hygienists).
    1987.   TLVs:  Threshold  Limit  Values  for  Chemical  Substances  in the
    Work   Environment  adopted  by   ACGIH  with   Intended  Changes  for
    1987-1988.  Cincinnati,  OH.  114 p.

    Clayton,  G.D. and  F.E.  Clayton,  Ed.    1981.   Patty's  Industrial
    Hygiene  and   Toxicology,  3rd  rev.  ed.,  Vol.  2A.   John  Wiley  and
    Sons, NY.  2878 p.

    Clayton,  G.D. and  F.E.  Clayton,  Ed.    1981.   Patty's  Industrial
    Hygiene  and   Toxicology,  3rd  rev.  ed.,  Vol.  28.   John  Wiley  and
    Sons, NY.  p. 2879-3816.
0267d                               -46-                             02/07/90

-------
    Clayton,  G.D.   and  F.E.  Clayton,  Ed.    1982.   Patty's  Industrial
    Hygiene  and  Toxicology,  3rd  rev.  ed.,,   Vol.  2C.   John  Wiley  and
    Sons, NY.  p. 3817-5112.

    Grayson, M.  and D. Eckroth,  Ed.   1978-1984.   K1rk-0thmer  Encyclo-
    pedia of Chemical Technology, 3rd ed.  John  WHey  and  Sons,  NY.   23
    Volumes.

    Hamilton, A. and H.L. Hardy.  1974.   Industrial  Toxicology,  3rd  ed.
    Publishing Sciences Group, Inc.,  Littleton,  MA.   575 p.

    IARC  (International  Agency  for   Research  on Cancer).   IARC  Mono-
    graphs  on   the   Evaluation  of  Carcinogenic  Risk   of  Chemicals  to
    Humans.  IARC,  WHO, Lyons, France.

    Jaber,  H.M.,  W.R.  Mabey, A.T.  L1u,  T.W.  Chou  and H.L.  Johnson.
    1984.   Data  Acquisition  for  Environmental   Transport   and   Fate
    Screening.    Prepared  by  the  Office  of  Health  and  Environmental
    Assessment,   Washington,   DC.  for   the Office  of  Solid  Waste,  and
    Emergency  Response,   Washington,  DC.   EPA  600/6-84-009.    NT1S
    PB84-243906, PB84-243955.   p.  45.

    NTP  (National Toxicology  Program).   1987.   Toxicology  Research  and
    Testing  Program.   Chemicals  on  Standard  Protocol.    Management
    Status.

    Ouellette,   R.P. and  J.A.  King.    1977.    Chemical  Week  Pesticide
    Register.  McGraw-Hill  Book  Co.,  NY.

    Sax, I.N.  1984.  Dangerous Properties of Industrial Materials,  6th
    ed.  Van Nostrand Relnhold Co.,  NY.

    SRI  (Stanford  Research  Institute).   1987.    Directory of  Chemical
    Producers.   Menlo Park,  CA.
                                /
    U.S.  EPA.   1986.  Report  on  Status  Report  In  the Special  Review
    Program,  Registration   Standards   Program  and   the  Data  Call   In
    Programs.  Registration  Standards and  the   Data  Call   In  Programs.
    Office of Pesticide Programs,  Washington,  DC.

    USITC  (U.S.   International   Trade  Commission).   1986.    Synthetic
    Organic  Chemicals.   U.S.  Production  and  Sales,  1985,  USITC  Publ.
    1892, Washington, DC.

    Verschueren,  K.   1983.   Handbook of  Environmental  Data  on  Organic
    Chemicals,  2nd  ed.   Van  Nostrand  Relnhold  Co., NY.

    Wlndholz, M., Ed.  1983.  The Merck Index,  10th ed.   Merck and Co.,
    Inc., Rahway, NJ.

    Worthing, C.R.  and  S.B.  Walker,  Ed.   1983.  The  Pesticide  Manual.
    British Crop Protection  Council.   695  p.
0267d                               -47-                             02/07/90

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     In  addition,  approximately  30 compendia  of  aquatic toxldty  data  were

reviewed,  Including the following:


     Battelle's  Columbus  Laboratories.   1971.   Water  Quality  Criteria
     Data   Book.   Volume  3.  Effects  of  Chemicals  on  Aquatic  Life.
     Selected  Data  from the  Literature  through 1968.   Prepared  for  the
     U.S. EPA under Contract No. 68-01-0007.  Washington, DC.

     Johnson,  W.W.  and  M.T.  Flnley.   1980.  Handbook of  Acute  Toxldty
     of  Chemicals  to  F1sh  and  Aquatic   Invertebrates.   Summaries  of
     Toxldty  Tests  Conducted  at  Columbia  National  Fisheries  Research
     Laboratory.   1965-1978.   U.S.  Dept.  Interior,  F1sh  and  Wildlife
     Serv.  Res. Publ. 137, Washington, DC.

     McKee,  J.E. and  H.W.  Wolf.  1963.  Water  Quality Criteria,  2nd  ed.
     Prepared  for  the  Resources  Agency  of  California,  State  Water
     Quality Control Board.  Publ. No. 3-A.

     Plmental, D.  1971.   Ecological  Effects  of Pesticides  on Non-Target
     Species.  Prepared for the U.S. EPA, Washington, DC.  PB-269605.

     Schneider, B.A.   1979.   Toxicology  Handbook.   Mammalian and Aquatic
     Data.   Book 1: Toxicology  Data.   Office  of Pesticide Programs,  U.S.
     EPA, Washington, DC.  EPA 540/9-79-003.  NTIS PB 80-196876.
0267d                               -48-                             12/19/89

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                                                                           APPENDIX B

                                                           Summary Table for c1s-1.2-01chloroethylene
Species
Inhalation Exposure
Subchronlc ID
Chronic ID
Carclnogenlclty 10
Oral Exposure
Subchronlc rat
Chronic rat
Carclnogenlclty ID
REPOBTABLE QUANTITIES
Based on chronic toxlclty:
Based on Carclnogenlclty:
Exposure

10
ID
ID

50 ppro 1.1-dlchloroethylene
In drinking water for 2 years
(9 mg 1.1-dlchloroethylene/kg/day)
50 ppm 1,1-dlchloroethylene
In drinking water for 2 years
(9 sag 1.1-dlchlorosthylene/kg/day)
J ID

1000*
10
Effect RfO or q]*

ID ID
ID ID
10 ID

LOAEL for 0.009
liver lesions mg/kg/day*
LOAEL for 0.009
liver lesions mg/kg/day*
10 ID



Reference

NA
NA
NA

Quasi
et al.. 1983
Quast
et al.. 1983
NA

Hong et al . .
1981
NA
        •Values derived for 1.1-dlchloroethylene adopted for 1,2-dlchloroethylene mixed Isomers  based on analogy

        10 - Insufficient data; NA = not applicable
CD
10

-------
                                  APPENDIX C
     DOSE/DURATION RESPONSE GRAPHS FOR EXPOSURE TO ds-1,2-OICHLOROETHYLENE
 C.I.    DISCUSSION
     Dose/duration-response   graphs   for   Inhalation  and  oral  exposure  to
 ds-1,2-d1chloroethylene,  generated  by  the method  of  Crockett et  al. (1985)
 using  the  computer  software  by Durkin  and Meylan  (1988)  developed  under
 contract  to ECAO-Clnclnnatl  are presented 1n Figures  C-l  through  C-3.   Data
 used  to generate these graphs are presented  1n  Section C.2.   In the genera-
 tion  of these figures, all  responses are  classified  as adverse (FEL, AEL or
 LOAEL)  or  nonadverse  (NOEL  or  NOAEL)  for plotting.   The  ordlnate expresses
 Inhalation  exposure  In either of two ways.   In  Figure C-l, the experimental
 concentration,  expressed  as  mg/m3,  was  multiplied  by the  time  parameters
 of  the  exposure protocol  (e.g.,  hours/day and  days/week), and  Is presented
 as  expanded  experimental  concentration   [expanded  exp  cone  (mg/m3)].   In
 Figure  C-2,  the  expanded  experimental  concentration  was multiplied by  the
 animal  Inhalation  rate  1n mVday and divided by  the animal  body  weight  In
 kg  to  calculate a dally dose In mg/kg/day.   The dally  dose  was  then multi-
 plied  by the  cube  root  of   the ratio of  the  anlmaV.human  body  weight  to
 adjust  for  species differences  In  metabolic rate  (Mantel  and Schnelderman,
 1975).   The result  was  multiplied  by  an absorption  coefficient  of 0.5  to
 adjust  to  an  equivalent  absorbed dose  and  then  multiplied  by  70  kg,  the
 reference human  body weight, to express the  human  equivalent dose as mg/day
 for  a   70  kg  human  [human  equlv dose  (mg/day)].    For  oral  exposure,  the
 ordlnate  expresses   dose   as  human  equivalent   dose.   The  animal  dose  In
mg/kg/day Is  multiplied by  the  cube root of  the  ratio of  tbe animal :human
 body  weight  to adjust  for   species differences   In  basal  metabolic  rate
 (Mantel   and  Schnelderman,  1975).  The  result Is  then multiplied  by 70  kg,


0267d                               -50-                             12/19/89

-------
 9
 U

 0
 U
 X
 t

 Q
 t1
 c

 t
 &
 X
 fc!
      •1800"
       100
                                                                           I	I
          8.001
(Inhalation  Exposure)
                                                     0.01
HUMRN EQUIU DURflTIOH (fraction lifespan)

           ENVELOP METHOD
    Key:  F . FEL
          L - LOAEL
          N . NOEL

          Solid line - Adverse Effects Boundary
          Dashed line » No Adverse Effects Boundary
                                     FIGURE C-l


              Dose/Duration-Response Graph  for  Inhalation  Exposure to
    c1s-D1chloroethy!ene:   Envelope Method (Expanded Experimental Concentration)
  0267d
           -51-
                                                                        12/19/89

-------
 A

 >
 «

 \
 9


 V
•0
fi
 0
 u

 I

 v
      1080
                                                                       I    I    I
          0.001
(Inhalation Exposure)
                                                                           J	I
                                                     e.ei
HUMRN EOUIU DURRIION (fraction lifespan)

           ENUELOP METHOD
     Key:  F . FEL
           L - LOAEL
           N . NOEL
           Solid line • Adverse Effects Boundary
           Dashed line - No Adverse Effects Boundary
                                      FIGURE C-2

               Dose/Duration-Response Graph  for  Inhalation  Exposure to
          ds-l,2-D1chloroethylene:   Envelope Method (Human Equivalent Dose)
   0267d
            -52-
12/19/89

-------
 V

 U
 (!)
 0
 a
 M


 0
•i
       1808
                                                                       i    i    r
                     LI
          8.001



(Oral Exposure)
                                                     e.ei
HUMflN EQUIU DURflTION (fraction lifespan)
    Key:  L - LOAEL
                                     FIGURE  C-3
                 Dose/Duration-Response Graph for Oral  Exposure  to
                     ds-1,2-D1chloroethylene:   Envelope Method
  0267d
          -53-
12/19/89

-------
 the  reference human  body weight,  to express  the human  equivalent  dose as
 mg/day  for a  70 kg human  [human equlv dose (mg/day)].
     The  adverse  effects  boundary  (solid line)  1s drawn  by  Identifying the
 lowest  adverse effect  dose  or  concentration  at  the  shortest  duration of
 exposure  at  which  an adverse effect  occurred.   From this starting point, an
 Infinite  line 1s  extended upward,  parallel  to  the  dose  axis.   The starting
 point  1s  then connected  to  the  lowest  adverse  effect  dose or  concentration
 at  the  next   longer  duration  of  exposure that has  an adverse effect  dose or
 concentration  equal   to  or  lower  than  the  previous one.  This  process Is
 continued  to  the  lowest  adverse  effect dose  or concentration.   From  this
 point,  a  line parallel  to the duration axis  1s  extended  Infinitely  to the
 right.  The adverse effects region lies  above the  adverse  effects boundary.
     Using the  envelope method, the  no adverse  effects  boundary  (dashed line)
 Is drawn  starting with  the  point  representing  the highest no adverse effects
 dose  or  concentration.   From this  point,  a  line parallel to  the duration
 axis  Is  extended  to  the  dose or  concentration  axis.   The starting point is
 then  connected to  the next equal or  lower no  adverse  effect  dose or  concen-
 tration at a longer   duration  of  exposure.   When  this  process  can no longer
 be continued,  a  line parallel to  the dose or  concentration axis 1s  dropped
 to  the  duration  axis.    The  no  adverse effects  region  lies  below  the no
 adverse  effects  boundary.   At  both  ends  of  the graph  between  the  adverse
 effects  and  no adverse  effects   boundaries  are  regions   of ambiguity.   The
 area  (1f  any) resulting  from Intersections  of  the  adverse  effects  and no
 adverse effects boundaries Is defined as the region of contradiction.
    In the censored data  method,  all  no  adverse effect  points  located In the
 region of Contradiction  are dropped  from  consideration,   and the No  Adverse
effects  boundary   Is  redrawn  so  that   It  does  not Intersect   the  Adverse

0267d                               -54-                             02/07/90

-------
effects boundary and  no  region of  contradiction  1s  generated.  This  method
results In the most conservative definition  of  the no adverse  effects  region.
    F1gue C-l represents the dose/duration  response  graph of  Inhalation  data
expressed as  expanded concentration  and  generated  by  the  envelope  method.
The boundary for the  region of  adverse effects  1s  defined by  a PEL  (Rec.  #1)
for  anesthesia   In  8  minutes  followed   by death  within   4   hours  In  rats
Inhaling 1600 ppm  cls-1,2-d1chloroethylene  and a  LOAEL  (Rec. #3)  for  dose-
dependent Increases 1n hexobarbHal sleeping time, zoxalamlne paralysis  time
and  Increased  formation  of 4-am1noant1pyr1ne  from  amlnopyrlne,  Indications
of  Interaction  with  the mixed  function  ox'idases  In rats  Inhaling 200  ppm.
The boundary  for the region  of no adverse effects   Is  defined by a  single
NOEL (Rec. #2)  for  absence  of fatalities  In rats  Inhaling  8000 ppm ds-1,2-
dlchloroethylene.   No region  of  contradiction was  generated by overlap  of
the  boundaries;  hence,  there  1s no  need  for  use  of  the  censored  method.
Figure C-2 represents the  same  data expressed as  the human equivalent dose.
Data were insufficient for  the derivation  of an Inhalation RfD.
    Figure  C-3  presents   the   dose/duration   response  graph  of  oral  data
generated by  the envelope method.  Since there  1s  only  one   datum  (a  LOAEL
for Increased liver alkaline  phosphatase  activities  1n rats  dosed  once  with
400  mg/kg,  used  to  construct  the  graph)  (Rec.  #1)  no boundaries   can  be
drawn, no region of contradiction can be  generated,  and  there Is no need for
use  of  the censored  method.    Data  regarding oral  exposure   to  ds-l,2-d1-
chloroethylene were Insufficient  for  derivation  of an RfD.    Adoption  of  the
verified oral RfD for  the l,l-1somer of  the  compound  was  recommended Instead.
0267d                               -55-                             07/25/90

-------
 C.2.    DATA  USED TO GENERATE DOSE/DURATION-RESPONSE GRAPHS
 C.2.1.    Inhalation Exposure.
 Chemical  Name:
 CAS  Number:
 Document  Title:

 Document  Number
 Document  Date:
 Document  Type:
ds-1 ,2-d1chloroethylene
156-59-2
Health and Environmental
ds-1 ,2-dichloroethylene
NR
NR
HEED
                            Effects Document on
========================
RECORD #1: Species:
Sex:
Effect:
Route:





================
Rats
NR
PEL
Inhalation





Body Weight:
Reported Dose:
Converted Dose:
Exposure Period:
Duration Observation:
Molecular Weight:
Inhalation hours/day:
Inhalation days/week:
# Inhal. Exp. days:
0.35 kg
1600 ppm
6340 mg/m3
1 day
1 day

4.00


Comment:
Citation:
Comment:

Citation:
               Number Exposed:     NR
               Number Responses:   NR
               Type of Effect:     DEATH
               SHe of Effect:     BODY
               Severity Effect:    10
Given  8000,  16,000  ppm
Death  within   4  hours
continuous exposure.

Smyth, 1937-1955
                      4  hours.   Anesthesia  In  8  minutes.
                       after  exposure.   Not  expanded   to
RECORD #2: Species:
Sex:
Effect:
Route:





Rats
NR
NOEL
Inhalation





Body Wt:
Reported Dose:
Converted Dose:
Exposure Period:
Duration Observation:
Molecular Weight:
Inhalation hours/day:
Inhalation days/week:
# Inhal . Exp. days:
0.35 kg
8000 ppm
3170 mg/m3
1 day
1 day

4.00


Number Exposed:     NR
Number Responses:   0
Type of Effect:
Site of Effect:
Severity Effect:    10

See previous record.

Smyth, 1937-1955
0267d
                     -56-
                                                  02/07/90

-------
RECORD #3:
Comment:
Citation:
Species:
Sex:
Effect:
Route:
Rats
F ema1e
LOAEL
Inhalation
               Number  Exposed:      10
               Number  Responses:    NR
               Type of Effect:      ENZYM
               SHe of Effect:      BODY
               Severity Effect:     1
Body Weight:
Reported Dose:
Converted Dose:
Exposure Period:
Duration Observation:
Molecular Weight:
Inhalation hours/day:
Inhalation days/week:
# Inhal. Exp. days:

8
NR
ENZYM
LIVER
1
0.35 kg
200 ppm
793 mg/m3
                                                                    day
                                                                    day
                                                                  8.00
Given  0,   200,  600,  1000  ppm,   not  expanded  to  continuous
exposure.    Dose-dependent   Increase  1n  hexobarbltal   sleeping
time,  zoxazolamlne  paralalysls  time  (8  rats),  and  Increased
formation  of 4-am1no-ant1pyr1ne In liver  mlcrosomes  (10 rats).

Freundt and Macholz,  1978
C.2.2.  Oral  Exposure.
Chemical Name:     c1s-l,2-D1chloroethylene
CAS Number:
Document Title:

Document Number:
Document Date:
Document Type:
   156-59-2
   Health and Environmental  Effects  Document  on
   ds-1,2-D1chloroethylene
   NR
   NR
   HEED

RECORD #1
Comment:
Citation:
Species:
Sex:
Effect:
Route:
Rats
Male
LOAEL
Gavage
Body Weight:
Reported Dose:
Converted Dose:
Exposure Period:
                                            Duration  Observation:  1  day
Number Exposed:     4
Number Responses:   NR
Type of Effect:     ENZYM
SHe of Effect:     LIVER
Severity Effect:    1

Given 0, 400,  1500 mg/kg,  single  dose.
liver alkaline phosphatase activity.

Jenkins et al., 1972
0.35 kg
400 mg/kg/day
400 mg/kg/day
1 day
                              Significant  Increase In
NR = Not reported
0267d
                     -57-
                                           02/07/90

-------