U.S. DEPARTMENT OF COMMERCE
National Technical Information Service
PB-278 015
An Ordering of the NIOSH Suspected
Carcinogens List Based on
Production and Use Data
Environmental Protection Agency, Washington, D C
Mar 78
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EPA 560/1-78-001
An Ordering of the NIOSH
Suspected Carcinogens List
Based on Production
and Use Data
Contract No. 68-01-4103
Prepared for
Office of Toxic Substances
U.S. Environmental Protection Agency
Washington, D.C. 20460
Charlie Auer
Project Officer
March 1978
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TECHNICAL REPORT DATA
(Please read Instructions on the revene before completing!
i. REPORT NO.
EPA 560/1-78-001
2.
4. TITLE AND SUBTITLE
An Ordering of the NIOSH Suspected Carcinogens List
Based on Production and Use Data
3. RE
3. REPORT DATE
6. PERFORMING ORGANIZATION CODE
7. AUTHOH(S)
. PERFORMING ORGANIZATION REPORT NO
9. PERFORMING ORGANIZATION NAME AND ADDRESS
Office of Toxic Substances
U.S. Environmental Protection Agency
Washington,'D.C. 20460
10. PROGRAM ELEMENT NO.
11. CONTRACT/GRANT NO.
EPA 68-01-4103
12. SPONSORING AGENCY NAME AND ADDRESS
Same as box 9
13. TYPE OF REPORT AND PERIOD COVERED
Final Technical Report
14. SPONSORING AGENCY CODE
IS. SUPPLEMENTARY NOTES
Biospherics, Inc., provided editing and supplemental technical information;
services in support of this project.
16. ABSTRACT
Building on an earlier EPA report entitled "On Ordering of the NIOSH Suspected '
Carcinogens List Based Only on Data Contained in the List" (EPA 560/1-76-001),
the present document represents the second OTS effort to arrange the substances
presented in the NIOSH Suspected Carcinogens Subfile in a meaningful and useful
way for EPA purposes. Employing readily available information on the uses and
commercial significance of the chemicals listed in the NIOSH Subfile, OTS has'
further refined the initial ordering into the four tables contained in this report.
17.
KEY WORDS AND DOCUMENT ANALYSIS
DESCRIPTORS
b.lOENTIFIERS/OPEN ENDED TERMS C. COS AT I Field/Group
Document is available to the public
through the National Technical
Information Service, Springfield,
VA 22151
Carcinogens
8. DISTRIBUTION STATEMENT
19. SECURITY CLASS (This Report)
20. SECURITY CLASS (Thispagtj
EPA Form 2220-1 (R«v. 4-77) PREVIOUS EDITION is OBSOLETE
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NOTICE
This report has been reviewed by the Office of Toxic Substances, EPA, and
approved for publication. Approval does not signify that the contents necessar-
ily reflect the views and policies of the Environmental Protection Agency, nor
does mention of trade names or commercial products constitute endorsement or
\
recommendation for use.
ii
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PREFACE
The National Institute of Occupational Safety and Health (NIOSH) annually
publishes the Registry of Toxic Effects of Chemical Substances (RTECS), formerly '"
called the Toxic Substances List. In 1975, NIOSH published a subfile of the
RTECS, Suspected Carcinogens, A Subfile of the NIOSH Toxic Substances List, which.
lists chemicals reported in the literature as having caused benign or malignant
.,'..- .;.₯.-
tumors in at least one species. The obvious concern over this list of chemicals
and the fact that some might fall within the Environmental Protection Agency's
(EPA's) regulatory jurisdiction by virtue of their use patterns led the EPA '.'
Office of Toxic Substances (OTS) to undertake an effort to identify those sub-
stances in the Subfile deserving OTS attention. Initially, the NIOSH Subfile was
reordered according to cited carcinogenicity data. That ordering (summarized in -
the Appendix) suggests the degree of concern that might be warranted regarding
the carcinogenic potential of the listed chemicals.
Employing readily available information on uses and commercial significance,
J - . ' ' .'
OTS has further refined the initial ordering into the four tables contained in
'.'.' " '.'. ' .'
this report. Table 1 lists chemicals that might need delineation of their envi-
ronmental hazard potentialparticularly their carcinogenic threat. The chem-
icals contained in Tables 2 and 3 are considered less significant at this time
because they either fall more appropriately under another agency's regulatory
authority (Table 2) or because (Table 3) insufficient information was developed '
'' ' '' > '-
to warrant the inclusion of the entries in another table. It should be. recog-
nized, however, that some chemicals in Tables 2 and 3 may become environmentally
important in the future as their uses change. Table 4 is a composite of the . '^
\ ! '" .!' . ,' ."
first three tables, presenting production and use information on those substances
An Ordering of the NIOSH Suspected Carcinogens List Based Only on Data
Contained in the List, available through the National Technical Infor- .
mation Service, Springfield, VA 22151, as NTIS publication PB-251-851.
iii
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investigated by other than environmentally significant routes of administration
which, nonetheless, produced tumors at sites remote from the point of introduc-
tion. Some of the entries in Table 4 might require additional definition as was
suggested for Table 1 chemicals.
The tables in this report share limitations with the NIOSH Subfile data. In
particular, a substance's inclusion in the NIOSH Subfile is based on the con-
clusions of the author(s) of the study cited that the investigated substance
produced a neoplastic or carcinogenic response. In many cases the only data
evaluation in evidence is that provided by the scientific community prior to
publication in private literature. Neither NIOSH nor OTS has attempted to
resolve questionable published data or to evaluate an author's interpretation.
It is not appropriate to conclude that all substances listed in this report are
carcinogenic or of regulatory interest to EPA.
iv
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TABLE OF CONTENTS
PREFACE
APPROACH
FIGURE 1.
FIGURE 2.
TABLE 1.
TABLE 2.
TABLE 3.
TABLE 4.
FLOW DIAGRAM OF THE APPROACH FOLLOWED IN THIS
PROJECT
CONTINUATION OF THE FLOW DIAGRAM PRESENTED IN
FIGURE 1
CHEMICALS FROM THE NIOSH SUBFILE OF SUSPECTED
CARCINOGENS (1975) WHICH HAVE COMMERCIAL SIG-
NIFICANCE AMI MAY tlAVK ENVIRONMENTAL
SIGNIFICANCE
CHEMICALS FROM THE NIOSH SUBFILE OF SUSPECTED
CARCINOGENS (1975) WHICH APPEAR TO BE OF
GREATER IMPORTANCE UNDER OTHER REGULATORY
AUTHORITY
CHEMICALS FROM THE NIOSH SUBFILE OF SUSPECTED
CARCINOGENS (1975) FOR WHICH LITTLE OR NO
INFORMATION CONCERNING COMMERCIAL IMPORTANCE
WAS FOUND
CHEMICALS FROM THE NIOSH SUBFILE OF SUSPECTED
CARCINOGENS (1975) WHICH WERE TESTED BY OTHER
THAN ENVIRONMENTALLY SIGNIFICANT ROUTES OF
ADMINISTRATION AND WERE FOUND TO PRODUCE
TUMORS AT REMOTE SITES
Page No.
ill
1
7
8
25
29
39
APPENDIX
REFERENCES
INDEX
49
54
57
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I. APPROACH
After the initial ordering of an updated version of the 1975 NIOSH Sus-
pected Carcinogens Subfile in March 1976, EPA made refinements to provide a
. - -
better definition of the environmental exposure for each substance on the list.
Efforts were made to ascertain the commercial significance of the chemicals.
This was done primarily by using information readily available in the secondary
sources referenced herein; however, examination of the primary literature was
also necessary in a few cases. The basic factors examined were production levels
(when available) and commercial applications. Chemicals that have received in-
depth carcinogenicity evaluations by the International Agency for Research on
Cancer (IARC) were also identified.
An understanding of the/approach used to develop this list is facilitated
by referring to Figure 1, a flow diagram presenting a schematic of the entire
' *''' . ' '
process. Starting from point A, a e.pmbination of machine and manual techniques
*-.*.* ' "
was used to reduce and define the list of 1,693 compounds contained in the ini-
tial EPA-ordered NIOSH Subfile of Suspected Carcinogens. First, the availability
of a Chemical Abstracts Services (CAS) registry number was determined for each
compound. This determination was important because only those chemicals pos-
sessing a CAS number would be eligible for the subsequent automated search; of
the 1,693 compounds in the NIOSH Subfile, only 928 had CAS numbers. The machine
manipulation (B) consisted of a comparison between the CAS-numbered NIOSH Subfile
entries.and those chemicals contained on the Stanford Research Institute's (SRI)
file of 26,755 commercially significant (COMSIG) chemicals. The intersection of
the two lists produced matches of 632 compounds.
NIOSH made this updated version of the published subfile available to'OTS on
computer tape.
1
-------
For the 765 substances having no CAS number, a manual search of the TSCA
Candidate List of Chemical Substances (April 1977) and other information sources
was conducted to determine the commercially significant chemicals (step C). This
' " "'*'. '''',
search soon indicated that the overwhelming majority of these compounds have.
little, if any, commercial significance. Generally, they are laboratory research
materials (e.g., experimental carcinogens), analytical reagents, and members of
certain structural classes known to have a proclivity to induce carcinogenesis.. .
Some substances in this latter group appear to have been synthesized at the
laboratory level to test a wider variety of substances in a given structural
class. Conceivably, certain compounds in this category could have some environ-
mental significance; examples are polynuclear aromatics and N-nitroso compounds.
Only 5 of the 765 compounds without CAS numbers were found >to have some com-
mercial significance; these were added to the list obtained from the COMSIG
intersection to yield a total of 637 chemicals.
Step D involved examination of the route of exposure (e.g., inhalation vs.
oral vs. injection, etc.) recorded for each chemical as represented by the third
digit of the OTS 4-digit ranking code. In general, an oncogenic response to
level 1 (oral) or level 2 (inhalation, dermal, or ocular) exposure was considered
more environmentally significant than responses following level 0 (injection,
implant, etc.) exposure. Accordingly, level 1 and level 2 chemicals were com-
" ~ '"''' i
bined and considered separately from level 0 compounds. All of the chemicals
from levels 1 and 2 (total of 383) were designated as "hits" in the present work
and would ultimately appear in one of the tables. Level 0 compounds (total of
254), on the other hand, were subjected to an additional refining step involving
a determination of level 0 compounds which reported the development of tumors at
sites remote from the point of administration. Evidence of this nature was con-
sidered more indicative of a chemical's possible environmental significance than
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reports that the chemical produced local tumors only. While flaws were evident
in this approach, it was felt that such a distinction was better than inclusion
of either all or none of the level 0 chemicals. Accordingly, the primary literar
ture was examined (step E) and the studies (i.e., compounds) were separated into
two groups: those reporting local tumors only (151 entries) and those having
evidence of remote tumor development (103 entries). The "local tumors only"
chemicals were given no further consideration, while the "evidence of remote ,
tumors" group would ultimately appear in various parts of Table 4.
All "hit" chemicals (basically level 1 and level 2 compounds plus the
"remote tumors" subset of the level 0 chemicals) were then subjected to essen-
tially the same examination process. Nonprime letters (e.g., F) indicate level 1
and level 2 chemicals, while letters prime (e.g. G') refer to the subset of level
0 chemicals.
The first common step (F and F') was an intensive examination of (predomi-
nantly) secondary sources of production and use information. A listing of the
publications consulted can be found in the "References" section. Only very
limited.information was available for a number of the "hit" chemicals; these were
assigned to Table 3 (G; 147 entries) or Table 4C (G?; 12 entries) and were listed
2
according to their OTS 4-digit rank designation. Compounds with identical OTS
rank numbers were listed alphanumerically by NIOSH sort key within each group.
While many of the substances in these two tables appear to be of limited com-
mercial significance (interpreting the paucity of production and use information
as somewhat indicative of minimal industrial significance), caution is advised
2 ' .->..-
OTS rank number a higher number indicates greater evidence of carcinogenic
potential (see Appendix).
-------
because inclusion in these tables does not reflect a definitive judgment.
The remaining chemicals were grouped on the basis of their reported uses.
Chemicals of primary interest to the Food and Drug Administration or EPA's Office
of Pesticides Programs were separated as follows (refer to Figures 1 and 2, pp. 7
and 8):
(a) food^cosmetics related chemicals: Table 2A (H; 4 entries) and Table 4B-1
(Hf; 2 entries).
(b) Pharmaceuticals: Table 2B (I; 40 entries) and Table 4B-2 (I1; 31 entries).
(c) pesticides in Table IB (J; 36 entries) and Table 4A-2 (Jf; 14 entries).
As before, all chemicals were ordered on the basis of their OTS rank code with .?;
the NIOSH sort key used as a second-level sorting parameter.
The remaining chemicals (a total of 200) represent a core group of sub-
stances from the NIOSH Subfile having the greatest potential interest to the EPA:
Office of Toxic Substances. Most are Industrial chemicals produced in amounts
ranging from less than 1,000 pounds to several billion pounds per year. Because
of the wide range in reported production volumes for these chemicals, a dual-
level sorting hierarchy was employed to order the entries. Production level was
considered first (highest to lowest), followed by the OTS 4-digit rank number.
(As before, entries having identical rankings were ultimately ordered alphanumer-.
ically by the NIOSH sort key.)
Accordingly, the order in which chemicals are listed in Table 1A (K; 156
entries) and Table 4A-1 (K'; 44 entries) indicates the relative significance of
these chemicals with regard to their potential for environmental exposure (and
thus their hazard potential). Of the 156 compounds in Table 1A, at least 60 are
clearly of commercial significance. Another 51 chemicals are reportedly produced
in quantities greater than 1,000 pounds per year. The remaining 45 chemicals
4
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are currently produced in quantities less than 1,000 pounds per year; however,
the information is sketchy and the chemicals may be of commercial importance in
the future, or might have been within the past few years. Seventy-eight sub-
stances in Table 1A have been evaluated by the IARC in its monographs. Seven
are indicated to be human positive carcinogens; 4, human suspected; 42, animal
positive; 6, animal suspected; 17, indefinite; and 2, negative.
Table 4A-1 contains 44 chemicals, 19 of which are of documented commercial
importance. Sixteen others are produced at levels in excess of 1,000 pounds per
year, while the 9 remaining chemicals are produced at levels less than 1,000 . '
pounds or their commercial importance in the recent past or future is uncertain.
Twenty chemicals in Table 4A-1 have been evaluated by the IARC. Of these, none
are human positive carcinogens; 3, human suspected; 9, animal positive; 3, animal
suspected; and 5, indefinite.
As a result of this exercise and other factors, preparation of hazard assess-
ment documents has started or is planned for such chemicals as epichlorohydrin,
ethylene glycol, and others. In addition, for selected unevaluated chemicals
(e.g., no IARC review) that are commercially significant, an in-depth evaluation
of carcinogenicity and other toxicity data will be performed by recognized
experts under extramural contract. Present plans call for the preparation of
periodic updates to this list as additional suspected carcinogens are identified
by NIOSH. However, no time frame has currently been established for this work.
Each of the four tables has seven columns. Column one identifies each
substance by its unique CAS number. (Only a few compounds in these tables do
not have CAS numbers. The CAS numbers used in these tables have been taken
3
IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to
Man.
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predominantly from the TSCA Candidate List of Chemical Substances [April 1977];
in cases where the substance was not contained in the Candidate List, either the
NIOSH Subfile-listed CAS number or the CHEMNAME data base-reported number was
used.) Column two gives the OTS rank number assigned to the chemical in the
original EPA-ordered version. Column three lists the alphanumeric sequence
designation used in the NIOSH Registry of Toxic Effects of Chemical .Substances, '."
which allows easy location of the main entry. Column four indicates the approx-
imate annual production level of a compound, from I representing 1,000 pounds to
V representing 1 'billion pounds. The latest available annual production figures
are used. Column five gives a common chemical or trade name for each substance.
Column six indicates whether an evaluation of carcinogenicity data has been
conducted by the IARC in its monograph reviews; it also contains a symbol repre-
senting the review conclusion at the time of preparation, ranging from HP for
human positive to AS for animal suspected, and ID for indefinite. The last
column lists the uses of the substance, as found in the various secondary references
consulted.
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1975
1975 Suap«eud
Careiaogoa Subfile
(1.693)
SXKCS Updat*
through 3/76
(51)
Baordnlng of Subflla
br OTS 4-dlgit (abed)
Rank Coda (1%,S93)
"T'l.uli 11111. «^r. 11 y
Significant" Rout**
(Inhalation, oral, datoal,
ocular) (383)
"Son-Biwiiuiiamcally
Significant" Eoucu
(Injwtloo, loplant,
«ec.) (254)
S««
FIGURE 1. Flow diagram of the approach followed in this project. (Figures in parentheses
represent the number of chemicals involved at each point in the process.) ;. \:-.-
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Table 1-
Chemlcals of
Interest to
EPA (192)
Table 2-
Chemlcals of
interest to
FDA (44)
Table 1A-
Industrial
chemicals (156)
Table IB-
Pesticides
(36)
Table 2A-
Food-cosmetics
related chemicals
(4)
Table 2B-
Pharmaceuticals
(40)
Table 4A-
Chemicals of
Interest to
EPA (58)
Table 4B-
Chemlcals of
interest to
FDA (33)
Table 4A-1-
Industrial
chemicals
(44)
Table 4A-2-
Pesticides
(14)
Table 4B-1-
Food-cosmetics
related chemicals
(2)
Table 4B-2-
Pharmaceuticals
(31)
FIGDRE 2. Continuation of the flow
diagram presented in Figure 1.
8
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TABLE 1. CHEMICALS FROM THE KIOSH SUUFILE OK SUSPECTED CARCINOGENS (1975)
WHICH HAVE COMMERCIAL SIGNIFICANCE AND MAY HAVE ENVIRONMENTAL SIGNIFICANCE
A) Commercially Significant (annual production in excess of 1000 Ib)
CAS NO.
000056235
001332214
000084651
000071432
000107211
000108952
007440020
000075014
000095807
OTS
RANK0
4313
4123
4111
3121
(7222)
3121
3121
4429
4222
(7323)
4112
'(4111)
NtOSH
SORT KEY
FG49000
CI64750
CB47250
CY14000
KW29750
SJ33250
QR59500
KU96250
, XS962SO
ANNUAL
PRODUCTION
Ib)
NAME
carbon tetrachloride
V (dyes)
IV
Ib)
IV
IV
asbestos
anthraqulnone
benzene
ethylene glycol
phenol
nickel
vinyl chloride
toluene-2,4-diaraine;
cr 76035
IARC
REVIEW0
AP
HP
HS
AS
HP
.REPORTED USES
Production of fluorocarbon refrigerants
and propellents; degreasing; agri-
cultural fumlgant; chlorinating
organic compounds; fire extinguisher;
dry cleaning of clothing
Brake linings; fireproof fabrics;
roofing composition; insulation;
filters; paint filler; rubber and
plastic relnforcer; diaphragm cells
Starting material to produce dyes
and organics; bird -repellant for
seeds; organic inhibitor
Manufacture of organic chemical inter-
mediates for styrene monomer, detergents,
nylon, aniline, antiknock gasoline;
artificial leathers, dyes; solvent
(printing inks)
Antifreeze; hydraulic brake fluids;
in electrolytic condensers; In
printers' inks; In ballpoint pen inks
Phenolic resins; organic compounds;
germlcldal paints; Pharmaceuticals;
dyes and indicators; epoxy resins;
disinfectant; reagent; antiseptic
Plating; alloys; coins; batteries;
magnets; electrodes; spark plugs;
catalyst for hydrogenatlng oils and
methanatlng fuel gases; ceramics
Polyvlnyl chloride and copolymer
resins; plastic adhesive; organic
synthesis; wire and cable coverings;
shoe soles; raincoats; textile
finishes
To produce toluene diisocyanate; dye
Intermediate; direct oxidation black
for furs and hair, *
Footnotes: see pp. 23 and 24.
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TABLE 1. (SECTION A continued)
CAS NO.
000123911
000106898
000096480
007803578
000123319
050825291
000067663
000079016
000091941
000137304
000151564,
OTS
RANK8
(4323)
3122
(3101)
3121
3121
3121
3121
3111
(4212)
3111
5416
4213
4212
NIOSH
SORT KEY
JG82250
TX49000
LU35000
MV80500
MX35000
OG20250
FS91000
KX45500
DD05250
Z1I05250
KX50750
ANNUAL
PRODUCTION6
IV
IV
IV
NAME
IV
IV
IV
IV
(>106 Ib)
III
III
dloxane
eplchlorohydrin
chloroform
trlchloroethylene
zlram; zinc dimethyl
dlthlocarbamate
IARC
REVIEW0
AP
AP
REPORTED USES
4-butyrolactone; ID
hydroxybutyrlc acid
lactone
hydrazlne hydrate
hydroqulflone
lead naphthenate
AS
AS
3,3'-dlchlorobenzldlne AP(C)
(base and salts)
ID
ethylenelmlne; azlrldlne AP(C)
Organic solvent
To make synthetic glycerins; epoxy
resins; solvent for gums, paints,.
lacquers, nail enamels, and cellulose
esters and ethers; cement for Celluloid;
curing propylene-based rubbers
Chemical Intermediate In production of
2-pyrrolldone; solvent for many polymers
and petroleum products
Reducing agent; oxygen scavenger In
boiler water treatment; chemical
Intermediate
Photographic developer; stabilizer
In paints, varnishes, motor fuels,
and oils; antloxldant; polymeriza-
tion Inhibitor; dye Intermediate;
medicine
Paint and varnish drier; wood
preservative; Insecticide; catalyat;
additive In lube oil and metallic
soaps
Production of fluorocarbon refrigerants
and propellents; fluorocarbon
plastics; fumlgant; Insecticide;
solvent; In fire extinguishers; In
rubber Industry
Solvent; degreaslng; dry cleaning;
manufacture of organic chemicals
and Pharmaceuticals; fumlgant; tex-
tile processing; refrigerant
Intermediate for azo dyes and pigments;
curing agent In Isocyanate-termlnated
resins for urethan plastics
Fungicide; rubber vulcanization
accelerator
Polymerized Into polyethylenelmlne;
to produce 2-azlrldlnyl; Intermediate
and monomer for 611 additives, Ion .
exchange resins, coating resins,
Pharmaceuticals, adheslves, sur-
factants, and polymer stabilizers
Footnotes: see pp. 23 and 24.
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CAS NO.
001302529
000101779
000101144
000915673
000062566
000105748
000094360
000110054
000086306
000135886
OOO13623S
OTS
RANK8
4121
4112
4112
4111
4111
3123
(3122)
3121
3121
3112
3112
NIOSH
SORT KEY
DS14000
BY54250
CY10500
QJ65500
YU28000
OF26250
DM85750
ER24500
JJ98000
QM45500
ZHO1750
ANNUAL
PRODUCTION
III
III
NAME
IARC
REVIEW0
III
III
III8
III
(consumption
estimate)
III
III
III
III
III
beryl
AP
4,4'-methylenedlanlllne
R
HOCA
amaranth; Red Dye
No. 2; CI 16185
thiourea
lauroyl peroxide
benzoyl peroxide
dl-t-butyl peroxide;
bis(1,1-dImethylethyl)
peroxide
N-nltrosodIphenyl-
aolne
1^
Neozone D ;
2-phenylamlno-
naphthalene
Butyl ZlmateR; zinc
'dlbutyldlthJo-
carbamate ''
AP(C)
ID
AP
REPORTED USES
Natural silicate for producing
beryllium; synthetic emeralds
Manufacture of polymethylene poly-
phenyllsocyanate, 4,4'-methylenedlphenyl
Isocyanate, 4,4'-methylenebis(cyclohexyla-
mine) , and poly(amlde-lmlde) resins and
fibers; dye Intermediate; corrosion
Inhibitor; analytical reagent
Cur-Ing agent for elastomers, epoxy
resins, and rubbers
Dyeing wool and cotton; In color
photography; as an Indicator In
hydrazlne ti[rations
In photosensitive papers; production
of flame-retardant textile sizes;
boiler water treatment; photographic
chemicals; vulcanization accelerator;
In silver-cleaning compounds; in glues
Bleaching agent, Intermediate, and
drying agent for fats, oils, and
waxes; polymerization catalyst
Bleaching agent for flour, fats, oils,
and waxes; polymerization catalyst;
drying agent for unsaturated oils;
production of Pharmaceuticals and
cosmetics; rubber volcanizatlon
without sulfur
Polymerization Initiator; organic
synthesis; Ignition accelerator for
dlesel fuels
Rubber vulcanization retarder;
pesticide
Rubber antloxldant
Accelerator.for latex dispersions,
cements, neoprene latexes, etc.;
ultra-accelerator for lubricating oil
additives
Footnotes: see pp. 23 and 24.
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Is)
CAS NO.
000097563
004680788
002611827
004548532
000614459
000627123
000842079
000111444
000057147
000532821
000092875
000050328
OTS
RANK8
4315
(5416)
4111
4111
4111
3121
3112
3112
(3101)
3111
3111
3111
7426
NIOSH
SORT KEY
XU88000
BQ43750
QJ65300
QK27050
SD94500
FD08750
QU49000
KN08750
>MV24500
ST33800
DC96250
ANNUAL
PRODUCTION
II
(>105 Ib)
II
II
II
II
II
II
II
II
II
(>103 Ib)
IARC
NAME REVIEW0
CI Solvent Yellow 3; AP
CI 11160B
Guinea Green B;
CI 42085
Ponceau 4R; Food Red 7;
CI 16255
Ponceau SX; FD&C Red (N)
No. 4; CI 16045
t-butyl perbenzoate
propyl carbamate AP
Sudan IR; CI 12055 AP
bis(2-chloroethyl) AP
ether
1,1-dimethylhydrazlne; AP
Dlmazine"; UDHH
chrysoldlne; CI 11270 AP
benzldine
6629 ' DJ36750
benzp(a)pyrehe
HP(C)
AP
REPORTED USES
Manufacture of dyes and medicine
Dye for silk and wool fabrics
Dye
Colorant for cosmetics and soaps;
(formerly in maraschino cherries)
Polymerization initiator for poly-
ethylene, polystyrene, polyacryl-
ates, and polyesters; chemical
Intermediate
Organic intermediate for resins;
as a durable-press fabric finisher
for cotton and cotton/polyester
blends
To color fats, oils, and waxes;
biological stain
Solvent for fats, waxes, greases, and
cellulose esters; scouring agent for
textiles; paints, varnishes and
lacquers; dry cleaning; soil fumlgaht;
cheolcal intermediate; wetting compounds
Storable high-energy rocket fuel;
synthesis of plant growth regulators;
chemical intermediate
Dye .-for silk and cotton; colorant
In textiles, paper, leather, inks,
.and wool; biological stain
Organic synthesis; biological stain;
stiffening agent in rubber compound-
ing; manufacture dyes; analytical
reagent
Cancer research; occurs in coal tars,.
cigarette smoke; and the atmosphere
as a product of Incomplete combustion
Footnotes) see pp. 23 and 24.
-------
CAS NO.
007787566
000684935
001304569
000051796
000094597. -
003761533
000057396
OTS
RANK8
6222
5529
5324
(5325)
4429
4212
4111
4111
NIOSH
SORT KEY
DS50000
YT78750
DS40250
FA84000
CY28000
ANNUAL .
PRODUCTION
QJ68250
SZ19250
(perhaps II)
000119904
000077781
007787497
000119937
00006467S
00013S206
4212
4122
4121
4113
4112
(4113)
4111
DD08750
WS822SO
DS28000
DD12254
WS787SO
NC47250
I
(likely II)
I
I
I1
I
I
NAME
beryllium sulfate
tetrahydrate
nltrosomethylurea;
NHU
beryllium oxide
urethan(e) ;
ethyl carbamate
safrole
I ARC
REVIEW
AP
AP
AP
AP
AP
3,3'-dlMethoxybenrldine; AP
CI 24110
dimethyl sulfate HS
beryllium fluoride
3,3'-dimethyl- AP
benzldlne; CI 37230
dlethyl sulfate AP
cupferron
Ponceau MX; CI 16150 AP
metepa ',""'"" AS
REPORTED USES
In refining beryllium
Widely used in laboratories to
synthesize dlazomethane; chemo-
therapeutlc
In nuclear reactor fuels and
moderators; electron tubes; tran-
sistor mountings; additive to glass
and ceramics; catalyst for organic.
reactions
Organic solvent; biochemical re-
search; intermediate for pharma-
ceutlcals, pesticides, and fungicides
Perfume; to denature fats in soap .
manufacturing; topical antiseptic;
pedlcullclde; carminative
Manufacture of azo dyes and pigments; '
dyeing of cotton
Methylatlng agent for organic
chemicals
To produce beryllium metal, alloys,
and glass; in nuclear reactors
Manufacture of dyes; analytical
reagent to detect acid and chlorine
In water
Ethylatlng agent; accelerator In
sulfatlon of ethylene; some sulfonatlons
Separation of copper and Iron from
metals; quantitative reagent for
detecting titanium, vanadates, and
aluminum
Textile and leather dye; colorant
for paper, inks, and wood stains;
(84.000 Ib In 197S)
Insect chemosterllant; crease- and
flame-prooflog of textiles;'Inter-
mediate; cross-linking agent
Footnotes: see pp. 23 and 24.
-------
CAS HO.
0000107302
000096093
PQ0110225
000598550
000109842
001333820
000091598
000056531
000060117
010034932
000062555
000096457
001335326 :
OTS
RANK
3223
(4323)
3122
(3121)
3121
3121
3111
7222
6517
4416
(4418)
4324
(5425)
4213
4212
4212
4212
NIOSII
SORT KEY
KN66500
CZ96250
AP85000
(' t-
PC24500
KL28000
CB66500
ANNUAL ,
PRODUCTION
I
QM21000
WJ 56000
BX73500
MV96250
AC89250
NI96250
. OF87500.
(likely II)
I
(I)
(I)
(I):.
(I)
(I)
(I)
(I)
dh -.'
NAME
chloromethyl methyl
ether
styrene oxide
acetyl peroxide
methyl carbonate
2-hydra z inoe thanol
chromium (VI) oxide
IARC
REVIEW
HS(C)
ID
ID
ID
2-naphthylaolne; HP(C)
CI 37270
DBS; dtethylstllbestrol HP
DAB; p-(dlmethyl- AP(C)
amlno)azobenzene;
CI 11020
hydrazlne sulfate
Chioacetamlde AP
ethylene thlourea AP
lead' subacetate c. AP
REPORTED USES
Intermediate In organic synthesis;
in ion-exchange resins
Highly reactive organic intermediate;
reactive diluent in epoxy resins
Initiator and catalyst for resins
Insecticide; durable-press fabric
finish for polyester/cotton blends
Analytical reagent; plant growth
regulator
Chemicals (catalysts, oxldlzers,
chromatics); plating; engraving;
anodizing; tanning; metal cleaning;
medicine; inks; paints; ceramic
glazes; textile mordant; colored
glass
Formerly an Intermediate in manu-
facture of dyes and antloxldants
but replaced by a.corresponding
-compound
Animal growth hormone; emergency .
contraceptive; biochemical research
To color .polishes and other wax
products; analytical reagent to
identify peroxldlzed fats, pH, and
free hydrochloric acid
Refining rare metals; in fungicides;
antloxldant; analytical reagent .to"
determine cobalt, cadmium, and
nickel; .in hematology tests
Substitute for hydrogen sulflde In
analytical chemistry
Accelerator In compounding and
curing rubber _s
> '
To clarify and decolorize organic
matter in solution; In-sugar
analysis as a decolorizer .-'"'
Footnotes: ant' 23 .and 24.
-------
CAS NO.
000075707
000680319
002465272
000531862
000080488
000108770
000108805
OTS
RANK8
4121
4121
4112
(4213)
4112
4112
4112
4112
NIOSH
SORT KEY
PB52500
TD08750
BY36750
DD15750
XT70000
XZ14000
XZ18000
ANNUAL
PRODUCTION
(I)
(I)
(I)
(I)
(I)
(I)
(I)
IARC
REVIEW0
000060355
000301042
000139651
000118923
020325400
001528741
000091952
4111
4111
4111
4111
4111
4111
4111 ,
AM 02 50
AI52500
BY96250
CB24500
DD10500
DV40000
DV87500
(I)
(I)
(I)
(I)
(I)
. (I)
000060015
4111
ET73500
(I)
NAME
perchloromethyl
mercaptan
HMPA; hempa;
hexamethylphos-
phoratnide
auramlne 0; CI 41000
benzldine sulfate (C)
methyl-p-toluene-
sulfonate
cyanurlc chloride
cyanurlc acid
acetamlde AP
lead acetate
4.4'-thloanlllne; 4.4'-
thlobls(benzenamlne)
anthranlllc acid;
o-amlnobenzolc acid
o-dlanlsldlne
dlhydrochlorlde;
3,3'-dlmethoxybenzldine
dlhydrochlorlde
4.4' -dlnltroblph'enyl
3,3'-dlamlnobenzldine
'trlbutyrln; '" '
glyceryl trlbutyrate
REPORTED USES
Organic synthesis; dye Intermediate;
fuolgant
Specialty solvent In organic synthesis;
patent for delclng additive for jet
fuels; experimental chemosterllant for
Insects; UV-lnhlbltor In polyylnyl
chloride
Dye for paper, textiles, and leather;
antiseptic; fungicide; biological stain
Organic synthesis; (ITC-llsted)
Accelerator; nethylatlng agent;
catalyst for alkyd resins
Chemical synthesis; dyestuffs;
Pharmaceuticals; explosives;
surfactants; herbicides; optical
brlghteners
Herbicide; laboratory source for
cyanic acid gas; Intermediate for
chlorinated bleaches; whitening
agents
Solvent for organic and Inorganic
compounds; plastlclzer; stabilizer
Dyeing and printing cottons; astringent;
manufacture of lead salts and colors
Dye Intermediate; formerly an anti-
malarial drug
Manufacture of dyes; synthesis of
perfumes and Pharmaceuticals
Manufacture of dyes; to produce
dlanlsldlne dllsocyanate (used in
adhesive systems and polymers)
Production of organic compounds
Copolymerlzed to make high-temperature-
resistant' polybenzlmidazole textile
fibers . . " .
Plastlclzer; synthetic flavoring
substance and adjuvant .
Footnotes: see pp. 23 and 24.
-------
CAS HO.
000131737
000593828
006080564
000108441
000093534
000136356
000106314
000100403
000130154
010028136
000590921
000105679
000095874 .
D00576261 '
000095658
OTS
RANK
4111
4111
4111
4111
4111
(4212)
3122
3121
3121
3121
3121
.3121
3121
3121
3121
3121
NIOSH
SORT KEY
JJ92750
MV29000
OF80500
XU28000
XU29750
XY26250
DK26250
GW66500
QL71750
RS82250
UE78750
ZE56000
ZE57750
ZE61250
ZE63000
ANNUAL
PRODUCTION"
(i)
(i)
(i)
(i)
(i)
(i)
(i)
(i)
(i)
(i)
000095578
000120832
000078935
3121
3121
3121
SK26250
SK8S750
.UC07000
(I)
(i)
(I)
(I)
(I)
(I)
(I)
(I)
NAME
dlplcrylanlne;
hexanltrodlphenylamlne
1,1-dlmethylhydrazine
hydrochlorlde
lead acetate
trlhydrate
3-methylbenzenamine;
m-toluidine
2-methylbenzenamlne;
o-toluldlne
diazpaminobenzene
qulnone
4-vlnylcyclohexene
1,4-naphthoqulnone
ozone
o-chlorophenol
2,4-dlchlorophenol
chloroacetone
3-bromopropIonic
acid '
2,4-xylenol
2,5-xylenol
2,6-xylenol
3,4-xylenol
IARC
REVIEWC
ID
AP
ID
REPORTED USES
Analytical reagent for potassium
determination; explosive booster
Chemical Intermediate
Medicine; lead salts; dyeing textiles,
waterproofing; varnishes; Insecticides;
antlfoulIng paints; analytical reagent
Manufacture of dyes and organic chemicals
Manufacture of dyes (makes colors
fast to acids)
Insecticide; organic synthesis; dyes
Oxidizing agent In photography; manu-
facture of dyes; strengthening animal
fibers
Intermediate to produce vinylcyclo-
hexene dioxide (a reactive diluent
In epoxy resins)
Polymerization regulator for rubber
and polyester resins, synthesis of
dyes and Pharmaceuticals; fungicide;
alglclde
Manufacture of bleaches, waxes,
textiles; disinfectant for air and
water
Organic synthesis (dyes)
Organic synthesis
Manufacture of couplers in color
photography; Insecticide formu-
lations; Intermediate In manufac-
ture of dyes and perfumes
Organic Intermediate
Disinfectants; solvents; pharma-
ceutlcals; insecticides and fungi-
cides; ploBtlcizera; rubber chemi-
cals; additives to lubricants and
gasolines; wetting agents; dye-
stuffs; 2,6-xylenol used to
manufacture polyphenyleneoxlde
Footnotes: see pp. 23 and 24.
-------
CAS NO.
000092671
000092933
000062759
000057578
004245776
001464535
004223103
000140794
001120714
OTS
RANK"
5416
5111
4429
4428
4326
(5427)
4222
(4101)
4222
4214
4213
NIOSH
SORT KEY
DU89250
DV56000
IQ05250
RQ73500
MF22750
EJ82250
RN86400
TL63000
RP54250
ANNUAL
PRODUCTION
X.
(-)
(->
, -
(-)
000148243
011097691
037317412°
000099809
000138896
4213
4212
4212
4112
4111
4111
VC42000
TQ13600
TQ13760
BX93500
BX71750
OK67300
NAME
p-blphenylamine;
l.l'-(biphenyl)-
4-amlne
4-nitrobiphenyl
IARC
REVIEW0
HP(C)
AP(C)
N-nltrosodimethylamlne; AP(C)
»INA
beta-proplolactone AF(C)
N-ethyl-N'-nltro-
N-nltrosoguanldine
l,2:3,4-diepoxybutane
vlnylcyclohexene dioxide ID
N,N'-dlnitrosoplperazlne
propane sultone AP
8-hydroxyquIncline ID
Aroclor 1254 AP
Knnechlor 500 AP
N,4-dinitroso-N-methyl- ID
aniline
4-nitroso-N,N-
dimethylanlltne;
' accelerine
REPORTED USES
Analytical reagent to detect sulfates;
positive carcinogen In cancer research
(apparently, no commercial production)
Chemical Intermediate to produce
4-amlnoblphenyl; organic research
Manufacture of rocket fuels; .solvents;
organic research
Disinfectant; Intermediate In organic
synthesis; vapor sterllant
Explosives; biological research
Curing .polymers; crossllnklng tex-
tile fibers; preservative
Manufacture of polymers; reagent
In organic synthesis
Intermediate In organic synthesis
Chemical Intermediate to Introduce
sulfopropyl groups; (production
discontinued In 1975)
Antlbacterial-antlfungal agent;
deodorant; for precipitating and
separating metals; analytical reagent
to detect bismuth
(PCB) Dielectric liquids for closed
electrical systems
(PCB) Dielectric liquids for closed
electrical systems
Rubber additive (retarder with
antloxldant and antl-flex-cracklng
properties)
Manufacture of organic compounds;
printing dyes; accelerator in
vulcanizing rubber
'(Commercial Mixture of aromatic
.amines - containing 40Z HOCA)
Footnotes: . see pp..23 and 24.
-------
CAS NO.
000097778
000103162
001701775
000094586
000118752
000101735
002385855
£ 000136925
000057567
OTS
RANK8
3112
3112
3111
3111
3111
3111
3111
3111
3111
NIOSH
SORT KEY
J012250
SJ77000
AI89600
DA61250
DK68250
JJ95000
PC82250
VT07000
VT29750
ANNUAL .
PRODUCTION
(I)
;
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
IARC ,
NAME REVIEW0
. disulflram; Antabuse" ID
monobenzone
raethoxyphenyl-
acetic acid
dlhydroaafrole AP
chloranll; tetrachloro-
quinone
p-isopropoxydl-
phenylamlne
. p
mlrex; Dechlorane AP
ethyl Selenac"; ID
selenium dlethyl-
dithlocarbamate
aeolcarbazlde; . ' -. .
aminourea
REPORTED USES'*
Treatment of alcoholism; antloxldant In
vulcanizing rubber (accelerator and
cure retarder) ; seed disinfectant;
fungicide
Rubber processing; deplgmentatlon
pharmaceutical
Preparation of Pharmaceuticals and other
compounds
Essential oil compositions; chemical
Intermediate (use as food additive
banned In U.S.)
Seed-protecting fungicide; dye
Intermediate; vulcanizing agent
Rubber antloxldant
Insecticide; fire retardant
Accelerator In rubber processing;
compounding rubbers; fungicide
Production of semlcarbazlde hydrochlo-
rlde (reagent for aldehydes and
ketones); Isolation of hormones and
fractions from essential oils
Minor Commercial Significance (annual production apparently below 1000 Ib)
DYES. DYE INTERMEDIATES
000492171
000056575
000494382
000492808
5111
4529
4222
4213
DV21000
VC21000
AR76000
BY35000
dlpheiiyllne;
2,4'-blphenyIdlamlne
4-nltroqulnollne-N-
oxlde
Acrldlne Orange base;
- CI 46005B
auramine base; .CI 41000B HP
Manufacture of azo dyes; analytical
reagent to detect tungsten
Organic synthesis
Dye for wool', silk, and leather;
manufacture .of acrlflavlne
Manufacture of auramlne 0 and Solvent
Yellow 34; antiseptic; dyeing, of'paper,
cardboard; textiles, and leather
' Footnotes: see pp. 23 and 24.
-------
CAS NO.
003564098
005141208
000099058
006368725
000085847
006416575
OTS
RANK8
4212
(4213)
4112
4111
4111
4111
4111
NIOSH
SORT KEY
QJ 66500
BQ49000
DG12250
QM28500
QM47250
ST29000.
ANNUAL
PRODUCTION NAME
() Ponceau 3R; CI 16155
( ) Light Green SF
Yellowish;
CI 42095
( ) 3-amlhobenzoi9 acid
Sudan Red 7B;
CI 26050
( ) Yellow AB;
CI 11380
Sudan Brown RR;
CI 11285
IARC
REVIEW'
AP
ID
(N)
ID
000084117
000085825
3121
3112
SF78750
QL59500
phenanthrenequlnone
FD&C Red No. 32
REPORTED USES
Used for dyeing wool; (dellsted by
FDA for use In foods, drugs, and
cosmetics)
Dye
Dye intermediate
Dye; colorant for waxes, polishes,
solvents, petroleum products, and
plastics
(Formerly used to color oleomarga-
rine); colorant for oil and spirit
products, biological stain;
(prepared from beta-naphthylamlne,
a carcinogen, which remains present
as an impurity)
Dye; colorant for waxes, polishes,
solvents, petroleum products, and
plastics
Organic synthesis; dyes
Isomer of Sudan II; colorant for
waxes, polishes, petroleum products,
and plastics
MISCELLANEOUS
000055185
000056495
000057976
000053963
6929
5829
5729
IA35000
FZ36750
CW38500
5529 " * ' . AB94SOO
(5729)
N-nltrosodlethylamlne; AP
DENA
methylcholanthrene
7,12-dlmethylbenz(a)-
anthraceneP
2-FAA; N-2-
fluorenylacetamlde
(C)
Gasoline and lubricant additive;
antloxldant; stabilizer; fiber
solvent; copolyner softener; In
condensers to Increase dielectric
constant
Organic synthesis; from combus-
tion of petroleum .products
Organic synthesis; from combustion
of petroleum products
Organic synthesis; (formerly, an.
experimental insecticide)
Footnotes: see pp. 23 and 24.
-------
CAS NO.
000545551
011096825
037353632°
012737870°
000079447
010124502
000564001
000096082
000512856
000108689
014239680
000156627
.006385586
000060344
OTS
RANK"
4111
4111
4111
4111
3123
(4224) .
3121
(7222)
3121
3121
3121
3121
3112
3111
3111
2.111
(3212)
NIOSII
SORT KEY
SZ17500
TQ13620
TQ13720
TQ13740
FD42000
CG35000
EJ87500
OS91000
OT01750
ZE64750
EU98500
GS60000
SN07000
MV56000
ANNUAL
PRODUCTION NAME
( ) trls(l-azirldinyl)-
phosphine oxide
( )" Aroclor 1260R
( )" Kanechlor 300R
( )" Kanechlor 400R
dlmethylcarbamoyl
chloride
potassium arsenlte
( ) meso-l,2:3,4-dlepoxy-
butane
limonene dioxide
(--) ascaridole
( ) 3,5-xylenol
( ) cadmium dlethyl
dlthlocarbamate
( ) calcium cyanamlde;
. lime nitrogen
( ) ' .sodium blthlonolate
.methylhydrazlne .
IARC .
REVIEW0 REPORTED USES
ID Antlneoplastlc agent; clothing dye;
photographic emulsion hardener;
insect chemosterllant; textile
applications
(PCB) Dielectric liquids for closed
electrical systems
AS (PCB) Dielectric liquids for closed
electrical systems
AS (PCB) Dielectrlcal liquids for closed
electrical systems
AP .Chemical intermediate in manufacture
of drugs, herbicides, pesticides, and
anthelmlntlcs
US Silvering mirrors (reduces the silver
salt to metallic silver)
AP Organic research (very limited produc-
tion appears likely); see EJ82250
Organic Intermediate; manufacture of
epoxy resins
Anthelmlntic; polymerization initiator
Component of commercial xylenol mixtures;
see ZES6000, ZE57750. ZE612SO, ZE63000
Accelerator for butyl rubber
Herbicide; fertilizer; .nitrogen
products; iron and steel hardener
Antimicrobial agent to control bacteria,
molds, and yeast .
.Used ,ln rocket fuels; intermediate in .
chemical synthesis
Footnotes: see pp. 23 and 24.
-------
TABLE 1. (SECTION B)
B) Pesticides
CAS NO.
000054626
.100060571
000072548
100150685
000061825
000063252
000077463
000309002
000645056
.
000082688
000117180
000101995
000120627
000133062
000053190
000051036
000999815
000080331
000510156
002303164
000315184 V
OTS
RANK
4222
4212
. 4212
4212
4212
4112
4111
4111
,,4111'
3122
3121
3121
3112
3112
3112
3112
3111
3111
3111
3111
3111
NIOSH
SORT KEY
HA10500
1017500
KI07000
YS63000
XZ38500
FC59500
AE71750
1021000 ,;;:
1, ' ,
OS10500 \]>
DA66500
DC01750
FD89250
DA57750
CW50750
KH78800
XS80SOO
BP52500
DB52500
DD227SO
EZ82250
FC07000
IARC
NAME REVIEW0
aralnopterin
dieldrin AP
TDE; ODD AP
monuron AP
ami t role; AP
aminotriazole
Sevin ; carbaryl ID -
R R
Acedapsone ; Rod! lone
! ' aldrln ID
hemel; hexamethylmelamine , ;
° l.;".^ - '"*'
-.-* '' qulntozene; PCNB AP
;:; 2,3,5, 6-tetrachloro-
.' . ' nitrobenzene ; .^-:
phenyluretban(e) ,
.-. sulfoxide '
:>-Vicaptan >.'
o,p'-TDE; AS
o,p'-DDD
plperonyl butoxlde
Cycocel
ovex
chlorobenzilate AP
di-allate * AP
'' mexacarbate; 'zectran '' ,
REPORTED USES
Rodenticide; antineoplaatic agent
Insecticide
Insecticide
Herbicide (no longer EPA registered)
Herbicide
Contact Insecticide; parasiticide (vet.)
Antibacterial agent
Insecticide
(1971, ITC listed) not sold in U.S.;
chernoaterllant for Insects .*
Fungicide for seeds and soil
Soil fungicide
Plant growth regulator
Insecticide; synerglst for pyrethrlns
Bacterlostat in soaps; fungicide in .
agriculture (seeds), paints, plastics,
leather, fabric, and fruit preservation
.Antineoplaatic agent; constituent
of commercial TDE(DDD)
Synergist for pyrethrlns and
insecticides
Plant growth regulator
Insecticide; herbicide; acarlcide
Insecticide; mltlclde
Herbicide '
Insecticide, roolluecicide. and
acarlcide for lawns and floners;
(not EPA registered for Coof crops)
Fuotnotes: '-' see pp. 23 and 24.
-------
CAS NO.
000128041
000101213
000122429
000319846
000319857
000058899
000072560'
000050293
000072559
000297789
N> 000115297
NJ
000088857
000088062
000900958
000140578
OTS
RANK3
3111
3111
3111
3111
(4212)
3111
3111
3111
3111
3111
3111
3111
3111
3111
3111
3111
(5313)
NIOSH
SORT KEY
FD35000
FD80500
FD91000
GV35000
GV43750
GV49000
KH57900
KJ33250
KV94500
PC12250
RB92750
SJ98000
SN15750
WH66500
WT29750
IARC
NAME REVIEW0
sodium dimethyl-
dtthlocarbamate
chloro-IPC ID
p
IPC; Proplmm jo
alpha-lindane AP
beta-llndane , AP
garana-llndane ID
PcrthaneR
DDT AS
DDE
Isobenzan
endosulfan
dlrioseb
2 ,4 , 6-trlchlorophenol
trlphenyltln
. , acetate
Aramite" AP
REPORTED USESd
Fungicide
Pre- and' post-emergence herbicide
Pre- and post-emergence herbicide
Insecticide
Insecticide
Insecticide
Insecticide
Insecticide
Degradation product of DDT found
as an Impurity In DDT residues
Insecticide
Insecticide
Insecticide; herbicide; ovlclde;
(Increases corn yield 5-10Z)
Herbicide; fungicide; defoliant;
preservative
: Fungicide; antlfeedlng compound for
Insect pest control
Acarlclde
Footnotes: see pp. 23 and 24.
-------
aNew OTS rank In parentheses assigned from data contained In Suspected Carcinogens - A Subfile of the Registry of
Toxic Effects of Chemical Substances (2nd Ed.), 1976. [When the route of administration Is unknown, the highest
exposure level (2) Is assigned.] ' ''
Production Key ' . '
3 '
« known <10 Ib; production figures available (IARC, EPA/OTS-1977, or elsewhere) '
( ) = assumed <10 Ib since not Hated In the Directory of Chemical Producers (DCP)
(I) » >10 Ib; listed In DCP (no production figures available; however, Inclusion In
the DCP Implies that a chemical ha a a production level greater than 1,-QOO .
pounds on total sales In excess of $1,000) ,. . ' .
I = >103 Ib; production figures available U.S. International Trade Commission (ITC), IARC, EPA/OTS-1977,
or elsewhere " v:
II « >10 Ib; production figures available ITC or elsewhere
Ill >10 Ib; production figures available ITC or elsewhere
IV - >10 Ib; production figures available ITC or elsewhere .
9 . ' ' '.>'.':'
V - >10 Ib; production figures available ITC or elsewhere
ro
CJ c
.-.
IARC Review: Evaluation of carclnogenlclty data on chemicals as reported by the International Agency for " -.
Research on Cancer (IARC) In their publication IARC Monographs on the Evaluation of the
: Carcinogenic Risk of: Chemicals to Man (Vols. 1-13) ;
HP - Human Positive
HS - .Human Suspected '
AP - Animal Positive
AS - Animal Suspected
ID - Indefinite .
(N) - Negative
{(C) - U.S. Occupational Standard-Carcinogen, as determined from NIOSH hazard review documents]
Sources . consulted for use Information are listed In References.
- "Organic research: compounds synthesized as experimental Carcinogens or as analogs to complete a structural aeries or
'- -'class, analytical reagents, or laboratory curiosities.
"Combined 'production of anhydrous hydrazine and hydrazlne hydrate estimated at 37 million pounds In 1974.
This substance was (apparently) deleted erroneously from the RTECS Subfile (1976). ' ' \ '
|*^" .the.re ls little apparent domestic production of thiourea, an estimated 3.7 nlll Ion pounds were Imported In 1973.
-------
TABLE 1 (continued)
'The name "urethane"; Is often applied to high molecular weight "polyurethanes" used as foams (Insulation), elastomers,
and coatings. However, these products are not made from the chemical urethane and do not generate It on decomposition.
No Information is available oh the domestic production of o-tolldlne; however, Imports In 1970 totaled 98,000 pounds.
'No I ARC Review noted In the RTECS Subfile (1976); however, lead acetate trihydrate, which Is equivalent to approximately
86Z lead acetate, Is AP. .
kNo IARC Review noted in the RTECS Subfile (1976); however, because l',l-dlmethylhyarazine'is AP, the addition of the
hydrochlorlde might not change Its carcinogenic effect on the animals tested.
*AP IARC Review noted in the RTECS Subfile (1976); however, the IARC Monograph reviewed an isomer with CAS NO. 106-B7r-6
(both substances are stereolsomerlc and share the common name vlnylcyclohexene dioxide). The Isomer reviewed in the
IARC Monograph Indicates an It) Review.
DNo IARC Review noted In the RTECS Subfile (1976); however, IARC Monograph Indicates ID Review.
"Restricted use as required by Section 6(e) of the Toxic Substances Control Act (P.L. 94-469) and regulations being
proposed and promulgated under this section.
°CAS No. as reported in the TSCA Candidate List of Chemical Substances (April 1977).
flhla compound Is identified also be a second CAS No.
NEO or'CAR notation deleted from 1976 edition of the Suspected Carcinogens Subfile of the Registry of Toxic Effects of
NJ Chemical Substances. After reviewing the primary references cited in the 1975 edition, it was determined that this
chemical's Inclusion In the 1975 Subfile was erroneous.
R
Registered trademark.
-------
< ; :TA'BL-'E'2. ' 'CHEMICALS' FROM THE NIOSH SUBFILE OF SUSPECTED CARCINOGENS (1975) WHICH
- APPEAR TO BE OF GREATER IMPORTANCE UNDER OTHER REGULATORY AUTHORITY
A) Fuod-Coametlc Related Chemicals
CAS NO.
000081072
000139060
000150696
000120581
000302227
000595335
Ni
°V 000054853
000366701
000072140
000121595
000059870
000057410
021083476
000551928
000555840 -
000057636
000723466
003565159
OTS
RANK8
4212
4112
4111
3111
5111
5111
4214
4214
4212
4111
4111
4111
(4212)
4111
4111
4111
4111
(4212)
4111
4111
NIOSH
SORT KEY
UE42000
CV71000
YT22750 .
DA59500
B) Pharmaceuticals
TU37500
TU40750
NS17500
XS47250
WP23600
CF92750
LT77000
MU10500
MU17500
NI50750
NJ08750
RC89250
WP07000 r
YR06000
IARC
NAME REVIEW
saccharin
calcium cyclamate
sucrol; dulcln
isosafrole
chlormadlnone acetate
megestrol acetate
isonlazld
procarbazlne
hydrochlorlde
sulfathlazole
carbarsone
nltrofurazone
phenytoln; 5,5-
d iphenylhydantoin
5.5-diphenyl-2-
thiohydantoln
dlnietrldazole
nlfuradene
R
Lynoral ; ethlnyl
estradlol
'sulfamethoxazole
Itrumll . sodium;
5-lodo-2-thlouracll
ID
AP
AS
AP
ID
HSd
AP
AP
REPORTED USES
Artificial sweetener
Artificial sweetener (no longer used)
Artificial sweetener (no longer used)
To produce perfume, flavors, pesticide
synerglsta, and hellotropen
Progestatlonal agent
Progeutatlonal agent (mixture as oral
contraceptive); antlneoplastlc agent
(vet.)
Antltubercular agent
Antlneoplastlc agent
Antibacterial agent
Amoebicide
Antibacterial agent
Antlconvulsant; antiseptic
Pharmaceutical analog synthesized for
research
Antlliistomonad (vet.)
Antibacterial agent
Action and use of estrogen in contra-
ception
Antibacterial agent .
Antithyrold agent
Footnotes: bee p. 28.
-------
CAS NO.
000056042
000051525
000055867
000055981
000305033
000051183
010345948
000148823
000480228
000076200
000302170
000064868
000091645
000056257
000123637
000077656
000126078
4000050066
000059052
OTS,
RANK0
4111
3313
3124
3122
3122
(4223)
3122
(4223)
3121
3121
(7324)
3121
3121
3121
3121
3121
(4222)
3121
3121
3121
3112
3111
3111
NIOStI
SORT KV
YR0875
YR1400
IA2100'.
EK1750
ES7525
XZ2100
AY3500
AY367S
CB1220
EJ5250
FM87DO
. GH0700
CN4200
RNSS'O
YK0520
YS29/0
WG9600
CQ682S
MA1220
IARC .
NAME REVIEW
methyl thlourac 11
propyl thiour ac 11
. mechlorethamlne hydro-
chloride; nitrogen
mustard hydrochlorlde
busulfan
chlorambucll
tretamlne;
triethylenemelamlne
medphalan; "
D-sarcolyslne
melphalan;
L-sarcolyslne
DithranolR
Trional*;
methylsul f onal
chloral hydrate
colchlcine
couroarln
cantharldln
paraldehyde
carbromal
grlseofulvln
phenobarbital
... .mettiotrexate
AP
AP
AP
AS
AP
AP
ID
IIS
AS6
AP
AS
AP
REPORTED USES
Antlthyroid agent
Antlthyroid agent
Antlneoplastlc agent
Antlneoplastlc agent
Antlneoplastlc agent
Antlneoplastlc agent; manufacture of
resinous products and textile
finishing agents outside U.S.
Antlneoplastlc agent (vet.)
Antlneoplastlc agent; Insect chemo-
sterllant
Dennatologlc; antlfungal (vet.)
Hypnotic
Sedative; hypnotic; to manufacture
liniments and DDT
Alkaloid to treat gout; to Induce
chromosome doubling In planta
Deodorizing and odor-enhancing
agent; pharmaceutical preparations
Vesicant
Hypnotic; solvent; chemical intermediate
Sedative; hypnotic
Antlfungal; antibiotic
Barbiturate
Antlneoplastlc agent; Insect
chemosterilant
Footnotes: see p. 28.
-------
TABLE 2. (SECTION B continued)
CAS NO.
000443481
000536334
003804895
OTS
RANK3
3111
3111
3111
NIOSH
SORT KEY
NI56000
NS03SOO
NS227SO
NAME
IARC .
REVIEW
Flagyl ; metronldazole APR
ethionamide
Neo-TizldeR;
isoniazid methane-
sulfonate, sodium
salt
APB
000072333
000097187
000098964
000141902
3111
3111
3111
3111
RC89600
SNOS250
UQ227SO
YR15750
ethinylestradlol 3-
methyl ether
bithionol
pyrazlnamide
thlouracll
AP
AP
REPORTED USES
Antlprotozoan drug (trichomoniclde)
Tuberculostatlc drug
Tuberculoatatlc drug
Frogestatlonal agent
Antibacterial, antlmold, antlyeast
(surfactant-formulated antimicrobial)
Tuberculostatlc drug
Formerly used as an antlthyrold agent
and to treat congestive heart failure
and angina pectorls
Footnotes: see p. 28.
-------
New OTS rank In parentheses assigned from data contained in Suspected Carcinogens - A Subfile of the Registry of
Toxic Effects of Chemical Substances (2nd Ed.). 1976. [When the route of administration Is unknown, the highest
exposure level (2) Is assigned.]
IARC Reviews Evaluation of carclnogeniclty data on chemicals as reported by the International Agency for Research'
on Cancer (IARC) In their publication IARC Monographs on the Evaluation of the Carcinogenic Risk of
Chemicals to Man (Vols. 1-13)
HP - Human Positive
HS - Human Suspected
AP - Animal Positive
AS - Animal Suspected
ID - Indefinite
(N) - Negative
|(C) - U.S. Occupational Standard-Carcinogen, as determined from NIOSH hazard review documents]
Sources consulted for use information are listed In References.
Oo dNo I/.RC Review noted in the RTECS Subfile (1976); however, the IARC Monograph indicates an HS Review.
6No IARC Review noted In the RTECS Subfile (1976); however, the IARC Monograph Indicates an AS Review.
(Olthranol is a tumor-promoting agent in mouse skin carclnogenesls experiments following Initiation
with either 7,12-dlaethylbenz[a]anthracene or urethane. An Increased Incidence of lymphomas was also
observed in mice painted with dithranol after urethane initiationIARC Monographs).
This substance was (apparently) erroneously deleted from the RTECS Subfile (1976).
8No IARC Review noted In the RTECS Subfile (1976); however, the IARC Monograph Indicates an AP Review.
NEC or CAR notation deleted from 1976 edition of Suspcrtnd Carcinogens Subfile of the Reentry of
Toxin Ffforfs of Clicmicnl Suhntnnces. .After-reviewing the primary reference cited In the 1975
edition, it was determined that this chemical's inclusion In the 197S Subfile was erroneous.
Registered trademark. '....'
-------
. TABLE' 3. 'CHEMICALS,' Ki«m -HIE NIOSII SUBFILE OF SUSPECTED CARCINOGENS (1975)
FOR WillCII LITTLE OR NO INFORMATION CONCERNING COMMERCIAL IMPORTANCE WAS FOUND
vO
CAS NO.
000070257
000531828
024554265
000053703
000053952
000924163
000615532
000100754
003570750
014901087
000306376
000059892
002373980
002541697
000153786
OTS
RANKa
6222
5429
5414
5414
4529
4519
4418
4418
(4419)
4315
4313
4313
(4314)
4313
4313
(4314)
4226
4225
4225
NIOSH
SORT KEY
DS29750
MF42000
AC66500
LQ31500
IIN26250
.AK85750
EJ40250
FC63000
TN21000
LQ92750
LZ59500
MV28000
QE75250
DV49000
CX15750
LL50750
ANNUAL
PRODUCTION
NAME
beryllium hydrogen
phosphate (1:1)
IARC
REVIEW0
AP
N-methyl-N'-nitro-N- AP
nitrosoguanidlne; MNNG*
furathlazole; NFTA AP
N-(4-(5-nltro-2-furyl)-^
2-thlazolyl)formamlde
dlbenz(ah)anthracene AP
N-hydroxy-2-
acetylaminofluorene
N-nltrosodlbutylamlne; AP
DBNA
N-methyl-N-nltrosoure-
than(e)6
N-nltrosoplperldine
nlfurthlazole
cycasln
1,2-dlmethylhydrazIne
dlhydrochlorlde
4-nltrosomorphollne
3,3'-dihydroxy-
benzldlne
7-methylbenz(a)-
anthracene
2-fluorenamine
AP
AP
HS
REPORTED USES
Occurs In beryllium refining
Organic research; preparation of
dlazomethane
Chemotherapeutlc agent; antibiotic for
Infections of the urinary tract
Organic research
Occurs from combustion of coal tar and
petroleum products
Organic synthesis
Organic research
Organic research
Organic research
Organic research
Formerly to make starch; (plant extract)
Analytical reagent
Organic research
Organic research; (benzidlne metabolite)
Occurs from combustion of coal tar
and petroleum products
Organic synthesis (experimental anti-
tumor agent)
Footnotes: see p. 38.
-------
CAS NO.
004637563
002422799
000542881
000334883
000057976f
000759739
001162658
001010613
000568752
002130565
000614959
000066273
000869012
013256138
000304289
004120789
000614006 .
002580781
OTS
RANK"
4225
4224
4224
(4226)
4223
4222
4215
(4429)
4214
4214
(4215)
4213
(4224)
4213
4213
4213
(4225)
4213
4213
4212
4212
V' ;-«212
(4213)
4212
NIOSI1
SORT KEY
VB9BOOO
CX24500
KN15750
PA70000
CW43750
YT31500
CY19250
VC01750
CW87500
DV33250
FB03500
PB26250
YS38500
YZ07000
AC07000
AC73500
,"'.' BY57750
CB10500
ANNUAL
PRODUCTION"
NAME
4-(hydroxyamlno)-
qulnollne 1-oxide
12-methylbenz(a)-
anthracene
bis(chloromethyl)
ether
dlazomethane
7»12-dlmethylbenz(a)-
anthracene
ethylnltrosourea
aflatoxln-Bl
IARC
REVIEW0
REPORTED USES
Organic research
Occurs In combustion of coal tar and
petroleum products
IIP(C) Contaminant of chloromethyl methyl ether
AP
AP
AP
4-(hydroxyamlno)-
quincline 1-oxide, '
hydrochloride
7-hydroxymethyl-12-
methylbenr(a)-
anthracene
3,3'-dlcarboxybenzldlne
N-ethyl-N-nltrosoure-
than(e)e
methyl methanesulfonate; AP
MMS
N-butyl-N-nitrosourea
N-nltroso-N-
ethylvlnylamlne
2,7-dlacetylamlno-
fluorene,
N-3-phenanthrenylacetaraide
N-nltroso-N-
methylanlllne
CI Reactive Blue-19'
Laboratory methylatlng agent
Organic synthesis; occurs In the combus-
tion of coal and petroleum products
Laboratory reagent to synthesize
dlazoethane
Secondary fungal metabolite
(mycotoxln)
Organic research
Occurs In combustion of coal tar and
petroleum products
Organic research
Organic research
Organic research
Experimental laboratory reagent
Organic research
Organic research
Organic research
v - '
Organic research .
Organic research-','' ,
Footnotes) see p. 38.
-------
TABLE 3. (continued)
CAS NO.
000932832
020917491
000568707
000055801
013256229
026049694
026049683
U> 026049707
004549433
003544238
007068839
018559972
000592621
022225327
007227910
006893205
004120778
OTS
RANK8
4212
4212
(4213)
4212
4212
'4212
4212
4212
4212
4122
(4112)
, 4122
4122
4114
4114
(4115)
4113
4113
(4115)
ill*-;;.
4112
NIOSH
SORT KEY
CM33250
CN49000
CW89250
CY03500
VQ31500
XJ46000
XJ49000
XJ50750
BA70000
BZ73500
E054250
AE70000
PC28000
AK87500
XY21000
AC57750
' AC71750
ANNUAL . IARC
PRODUCTION NAME REVIEW0
( ) N-nltrosohexamethyl-
enelmine
( ) octahydro-1-
-nltrosoazoclne
( ) 12-methanol-7
me thy Ibenz (a ) -
anthracene
( ) 3-methyl-4 '-(dimethyl-
am lno)azobenzene
N-nltrososarcoslne
( ) 2-(2,2-dlmethylhydra-
zino)-4-(5-nltro-2-
furyDthlazole
( ) 2-hydrazino-4-(5-nitro-2-
furyl)thlazole
( ) 2-hydrazino-4-(4-nltro-
phenyl)thlazole .': .
( ) N-nltrosomethylallylamlne
( ) 3-methoxy-4-
amlnoazobenzene
N-nethyl-N-butylnltroaamlne
( ) 4-acetamldostllbene
( ) methylazoxymethanol AP
acetate
( ) N-hydroxy-3-fluorenyl-
acetamlde
3,3-dlmethyl-l-
phenyltrlazene
( ) ...... l_methoxy-2-acetanildo-
fluorene
(--) ; ' ' H-2-phenanthrenylacetamlde .
REPORTED USESd
Organic research
Organic research .
Occurs In combustion of coal tar
and petroleum products
Organic research
Organic research
Experimental carcinogen
Experimental carcinogen
Experimental carcinogen
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research . " .-..
'. '..'. Footnotes: see p. 38;.^V'
-------
Is)
CAS NO.
000621909
003671714
010048132
013256070
010048325
013256230
013344508
000625229
016690441
000843345
018997621
017210489
020917504
018463860
OTS
BANK3
4112
4112
4112
(4123)
4112
4112
4112
4112
4112
4111
4111
4111
4111
4111
4111
NIOS1I .ANNUAL
SORT KEY PRODUC
BY59500 ( )
DC03500 ( )
LV17500 ( )
SC12250 ; (. )
UQ05250 ( )
UT36750 ( )
VQ33250
WS77000 ( )
AC59500 ( )
AE42800 ( )
BX87500 ( )
BZ66500 ( )
C017SOO ( )
» B5750 ( )
018463859
4111
DL38500
018559927
4111
DL40250
001628586
4111
DLA2000
Footnotes: see p. 38.
NAME
N-methyl-4-arainoazo^
benzene
N-hydroxy-N-2-
fluorenylbenzamlde
sterlgmatocystln
N-methyl-N-nitroso-
pentylamine
parasorblc acid
4-((ethylnltrosamlno)-
methyl)pyrldlne
N-nltrososarcoslne
ethyl ester
dlbutyl sulfate
N-(7-nethoxy-2-
tluorenyl)acetamide
4'-hydroxy-4-acetamldo-
stllbene .
N.N-dlmethyl-4-(2,3-
dlnethylphenyl)-
azo)anlllne
3,4'-dlmethyoxy-4-
amlnoazobenzene
N-nltroso-
octamethyleneiraine
N,N-dimethyl-4-
benzlmidazol-4-
ylazo)anillne
N,N-dloiethyl-4-(6-
benzothlazolylazo)-
anillne
N,N-dimethyl-4-(7-
benzothlazolylazo)-
anlllne
p-(diroethylamino)-
styrlbenzothlazole
IARC
REVIEW^
REPORTED USES
AP
AS
Organic research
Organic research
Metabolite of Asperglllua
versicolor
Organic research
Natural acidifying agent in food
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research . .
-------
CAS NO.
000937406
8
003817116
h
000067210,
010087895 ,
OTS
RANK"
4111
4111
4111 '
(4212)
4111
4111
4111
NIOSI!
SORT KEY
DP63000
DV03500
EL12250
E051000
;ES7000p
-..CU71750
ANNUAL .
PRODUCTION
-(-)
IARC
REVIEW
005432280
000203645
005834173
1
002581693
007346147
013256127
006893249
000525644
000129793
005036033
4111
4111
4111
4111
4111
4111
4111
4111
4111
4111
4111
CX15750
.CY56000
HP49000
IIP87500
JJ97000
KV36750
KV43750 .
LL54250
LL69800
LL91000
.'.''. . NJ07066: .
<->
V (-)
, (-)
(-)
( )
(-)
( )
(-)
(-)
(-)
: (-)
NAME
N-methyi-N-nitroao-
benzylamlne
4'-nltro-4-
biphenylamlne
N-butyl-N-(4-butanol)
nltrosamlne
N-ethyl-N-nltroso-t-
butylamlne
DL-ethlonln,e
l,l-dlphenyl-2-
propynyl-H-cyclo-
- hexylcarbamate"- V '
N-methyl-N-nitroso-
cyclohexylamlne
'- All^cyclopenta (def ) -
phenanthrene
2-methoxy-3-amlno-
dlbenzofuran
N-(6-oxo-6H-dibenzo(b,d)-
pyran-l-yl)acetamlde
4-((p-nltrophenyl)azo)-
dlphenylamlne
N.N'-dlnltroso-N-N'-
dlethy1-1,2-ethaned iamlne
N,N'-dlnltroso;-N-N'-
dlmethyl-ll2-ethanedlamlne
l-methoxyfluoren-2-
amlne, hydrochlorlde
2,7-dlamlnofluorene
2,4,7-trlnltrofluoren-
9-one
l-(2-liydroxyethyl)-3-
(((5-nltro-2-furanyl)-
raetliylene) amlno) -2-
Imldazolldlnone - '' '. '
REPORTED USES
Organic research
Organic research
Organic research
Organic research
1 Experimental pharmaceutical
Organic research
Organic research . . .
Organic research
Organic research
Organic research
Organic research '
Synthesized as a possible antlturaor
agent
!
Synthesized as a possible antltumor
agent
Organic research
Laboratory reagent
Organic research
Synthesized as-a possible urinary tract
antibacterial agent ' . '
Footnotes: a o. 38.
-------
U>
CAS NO.
017309874
019471273
014816672
002401856
006240557
005096184
013115281
004176538
001892542
000947739
003851169
019456736
019456758
017416181
017416170
017400690
OTS
RANK3
4111
4111
4111
4111
:;4111
4111
4111
4111
4111
4111
4111
4111
4111
4111
4111
4111
NIOSH
SORT KEY
NK79300
OL01750
PB05250
QJ24500
QJ36750
QM42000
QM43750
SF94500
SF98000
SG01750
TH75250
UT22750
UT24500
UZ98000
/VB54250
VB57750
ANNUAL
PRODUCTION
IARC
REVIEW0
NAME
N,N-dimethyl-p-(6-
lndazylazo)anlllne
N,N-dlmethyl-4-
((2,5-dimethyl-4
pyrldinyl)azo)
aniline, N-oxlde
soterenol
hydrochlorlde
l-chloro-2,4-dlnltro-
naphthalene
1,2-dichloro-3-nltro-
naphthalene
3-raethyl-2-naphthyl-
amlne, hydrochlorlde
3-nltro-2-naphthyl-
aalne
1-phenanthrenamlne
3-phenan threnamIne
9-phenanthrenaolne
N,N'-dlmethyl-N,N'-
dlnltrosophthalamlde
N,N,2,3-Cetramethyl-
4(4-pyrIdlnylazo)anlline,
N-oxlde
N,N,2,5-tetramethyl-4-
4(4-pyrldlnylazo)anlllne>
N-oxlde
2'-methyl-5'-(p-dlmethyiamlno-
phenylazo)qulnoline
5-(p-dlmethylanlno-
phenylazo)qulnoline :
3'-methyl-5'-(p-dlmethylomlno-
phenylazo)qulnollne
REPORTED USES
Organic research
Organic research
Formerly an adrenerglc stimulant
pharmaceutical
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic Intermediate
Organic research
Organic research
Organic research
Organic research
Organic research .'
Footnotes:, see p. 38.
-------
OJ
Ln
CAS NO.
017400703
017400656
017416205
019716211
017400689
017416216
004008484
023521133
023521144
000838959
013256218
000626482
000189559
000056553
000652040
OTS
RANK°
4111
4111
4111
4111
4111
4111
4111
4111
4111
4111
4111
4111
3225
3124
3124
NIOSI1
SORT KEY
VB59500
VB61250
VB63000
VB71750
VB75250
VB77000
VC82250
VD19800
VD20000
WJ40250
XN08000
YR07000
DI57750
CV92750
0194500
ANNUAL
PRODUCTION
NAME
IARC
REVIEW0
6'-methyl-5'-(p-dlmethyl^
amlnophenylazo)-
qulnollne
7'-methyl-5'-(p-dlmethyl-
arainophenylazo)-
quincline
B'-inethyl-S'-Cp-dlmethyl-
aminophenylazo)-
qulnollne
4- (p- (d ime thylamlno) -
styryD-6,8-
dlmethylqulnollne
S'-methyl-S'-Cp-dlmethyl-
aminophenylazo)-
qulnollne
2-methyl-5l-(p-dimethyl-
amlnophenylazo)quinollne
5-nttro-8-hydroxyquIncline
5-(p-dimethylamlno-
. phenylazo)qulnoxallne
6(p-(dlmethylamlno-
phenylazo)qulnoxallne
cis-4-diraethylamino-
stllbene
N-nltrosomethylamlno-
sulfolane
6-methyluracll
3,4:9,10-dIbenzopyrene AP
benzanthrene
5-methyIbenzo(c)-
phenanthrene
AP
REPORTED USES
Organic research
Organic research
Organic research
Organic research
Experimental carcinogen
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic synthesis
Occurs In combustion of coal tar and
petroleum products
Occurs In combustion of coal tar and
petroleum products .
Occurs In combustion of coal'tar'and
petroleum products
'. Footnotes: see p. 38.
-------
CAS NO.
000226368
000205992
000207089
000105408
000479232
000218019
000224420
000192654
000225514
000205823
000195197
000192972
005929011
000215587
000189640
000106832
002426075
. *.. . » . 1
000141377
OTS
RANK3
3124
3122
3122
,.,,;-; T. f
3122
3122
3122
3122
3122
3121
3121
3121
3121
(3223)
3121
3121
3121
3121
3121
3121
NIOSH
SORT KEY
HN08750
CU14000
DF63500
FC26250
FZ26250
GC07000
IIN10500
QUU750
CU29750
DF63000
DI82250
DJ42000
DJ78750
DM19250
11057750
RG15750
RG94500
RN77000
ANNUAL . IARC
PRODUCTION NAME REVIEW0
( ) dlbenz(ah)acrldlne AP
( ) benzo (b)f luoranthene AP
( ) benzo (k)f luoranthene
( ) N-methyl urethan(e)
( ) cholanthrene
( ) ' chrysene AP
( ) dibenz(a,j)acridlne AP
( ) dlbenzo(a,e)pyrene AP
( ) . benz(c)acrldine AP
( ) benzo(j)fluoranthene AP
( ) . benzo (c)phenanthrene
( ) benzo (e)pyrene AS
(--) 1 : 2-benzopyrene plcrate
( ) dlbenz(ac)anthracene
(--) dlbenzo(b,def )chrysene AP
butyl-9,10-epoxy-
stearate
( ) ' '. l,2:7,8-diepoxyoctane
~ Epoxlde 201R AP
REPORTED USES*1
Occurs in combustion of coal tar and
petroleum products
Occurs in combustion of coal tar and
petroleum products; in smoked fish an
meats
Occurs in combustion of coal tar and
petroleum products
Organic synthesis
Organic synthesis
Organic synthesis
Occurs In combustion of coal tar and
petroleum products
Occurs in combustion of coal tar and
petroleum products
Occurs lnvcombustlon of coal tar and
petroleum products
Occurs in combustion of coal tar and
petroleum products
Occurs in combustion of coal tar and
petroleum products
Occurs in combustion of coal tar and'
petroleum products
Occurs in combustion of coal tar and
petroleum products
Occurs In combustion of coal tar and
petroleum products
Occurs in combustion of coal tar and
petroleum products
Organic research
Synthesized as a carcinogen in organ
research
No longer used (replaced by a related
compound)
Footnotes: see p. 38.
-------
CAS NO.
000219421
000129000
000253827
000100538
000138590
000842002
OTS
RANK3
3121
3121
3121
3121
3112
3112
NIOSH
. SORT KEY
_ SF85250
UR24500
VA12250
XT86500
CU46000
UR10500
ANNUAL
PRODUCTION
(-)
(-)
(-)
<->
( ) '
( )
NAME
IARC
REVIEW
023746341
3111
EY94500
003693229
020566170
000779475
002235598
006120101
000482495
3111
3111
3111
3111
3111
2111
HP45500
WZ03500
WZ05250
XS43750
ZE72500
VS31500
plienanthro (1,2-d ) thlazole
pyrene
quinazollne
alpha-toluenethlol
shlklmlc acid
ENS; A-(ethylsufonyl)-
1-naphthalenesul-
f onamlde
bis(2-iiydroxyethyl)-
dithiocarbamlc acid,
potassium salt
2-dibenzofuranamlne
4-(methylhydrazone)-
N-lsopropyltereph-
thalaldehydamide
N-lsopropyl
terephthalamic acid
N-isopropyl-alpha-
(2-methylazo)-p-
toluamlde
4-d imethylamino-3,5-
. xylenol
dolsynollc acid
REPORTED USES
Organic research
Biological research; organic synthesis
Synthesized from trlcycloqulnazoline
for cancer research
Occurs from petroleum refining
Organic research
Organic research
Organic research
Occurs in combustion of coal tar and
petroleum products
Organic research
Organic research
Organic research
Organic synthesis
Synthetic estrogen
Footnotes: see p. 38.
-------
New OTS rank In parentheses assigned from data contained In Suspected CarcinogensA Subfile of the Registry of
Toxic Effects of Chemical Substances (2nd Ed.). 1976. [When the route of administration la unknown, the highest
exposure level (2) Is assigned]. ~~
Production Key (annual)
3 '
known <10 Ibj production figures available (IARC, EFA/OTS - 1977, or elsewhere)
(--) - assumed <10 lb; not listed In the Directory of Chemical Producers (DCP)
IARC Review; Evaluation of carclnogenlclty data on chemicals as reported by the International Agency for Research
on Cancer (IARC) In their publication IARC Monographs on the Evaluation of the Carcinogenic Risk of
Chemicals to Man (Vols. 1-13)
. HP - Human Positive
HS - Human Suspected '
AP - Animal Positive
AS - Animal Suspected
ID - Indefinite
(N) - Negative
[(C) - U.S. Occupational Standard-Carcinogen, as determined from NIOSH haiard review documents]
Sources consulted.for use Information are listed In References.
Organic research: compounds synthesized as experimental carcinogens or as analogs to complete a structural series
or class, analytical reagents, or laboratory curiosities.
6The name "urethane" Is often applied to high molecular weight "polyurethanes" used as foams (Insulation), elastomers,
and coatings. However, these products are not made' from the chemical urethane and do not generate It on decomposition.
fCAS No. as reported in the TSCA Candidate List of Chemical Substances (April 1977)j it is Identified also by a second CAS No.
8The CAS No. (001204791) reported in the RTECS Subfile (1976) is incorrect and Is assigned to 4'-amino-(l,l'-biphenyl)-4-ol in the
TSCA Candidate List.
''the CAS No.. (004549444) reported In the RTECS Subfile (1976) Is Incorrect and is assigned to the n-butyl isomer (N-ethyl-N-nitroso-1-
butylamlne) in the TSCA Candidate List of Chemical Substances (April 1977). The present compound Is not listed in the TSCA Candidate
List. _ ' ' ' .,-. , . -.' ./ ., ' -
^The.CAS No; (005096195) reported in the RTECS Subfile (1976) Is Incorrect and is assigned to the (pyran-2-yl) form in the TSCA Candidate
. List. The present compound is not listed in the TSCA Candidate List. :'
R ' '.
Registered trademark.
-------
: TABLE 4. ' (illlCMICALS FROM flit: N10SII SUBFILE :OK .SUSl'liCTlSO CAKtlNOUKNS UVOJ WIIIUI WhKK IWitU 11*
OTIIKH THAN ENVIRONMENTALLY SIGNIFICANT ROUTES OF ADMINISTRATION AND WERE FOUND TO PRODUCE TUMORS AT REMOTE SITES
A-l) Commercially Significant (annual production in excess of 1000 Ib)
CAS NO.
007440473
OTS
RANK8
4102
N10SI1
SORT KEY
CB42000
001308389
000091203
4102
4101
CB64750
QJ05250
000079118
3101
AF85750
000092524
000302012
000078002
001401554
3101
3101
(3112)
3101
4101.
DU80SOO
MU71750
TP45500
WW50750
ANNUAL
PRODUCTION
IV
(> 107 Ib)
IV
IV
NAME
chromium
IARC
REVIEW0
AS
chromium (III) oxide
naphthalene
AS
IV
chloroacetlc acid
IV
IV
"I
(> 10°
blphenyl; dlphenyl
hydrazlne
tetraethyl lead
tannlc .acid
AP
ID
AP
REPORTED USES
Alloying and plating element on metal
and plastic substrates for corrosion
resistance; chromium-containing and
stainless steels; nuclear and high-
temperature research; constituent of
Inorganic pigments
Metallurgy; green paint pigments; .
ceramics catalyst In organic synthesis;
green granules In asphalt roofing;
component of refractory brick
Intermediate (phthalic anhydride,
naphthol, chlorinated naphthalenes,
solvents, dyes); moth repellent;
fungicide; explosives; cutting fluid;
lubricant; synthetic resins; synthetic
tanning; wood preservative; solvent;
textile chemicals
Herbicide; preservative; bacterlostat;
Intermediate In production of carboxy-
methylcellulose, ethyl chloroacetate,
glyclne, synthetic caffeine, sarcoslne,
thloglycollc acid, dyes, EOTA, 2,4-D,
and 2,4,5-T
Organic synthesis; heat-transfer agent;
funglstat In packaging of citrus fruits;
plant disease control; manufacture of
benzldlne; dyeing assistant for polyesters
Rocket propellant; oxygen scavenger In
boiler water treatment; production of
agricultural chemicals, Pharmaceuticals,
and blowing agents; solder fluxes;
polymerization catalyst
Antiknock additives for gasoline
Textile mordant and fixative; writing and
printing Ink. additive; deflocculatlng
agent; tanning agent for leather; post-
treatment of acid-dyed nylon; pharmaceu-
tlcals; chemical Intermediate; food addi-
tive '"'. ..':':
Footnotes: see pp. 47 and 48.
-------
TABLE 4. (SECTION A-l continued)
CA8 NO.
000149304
000074317
000373024
0143245518
010108642
000050180
001066304
000134327
000080115
010141056
007733020
OTS
RANK
3101
3101
4101
3101
4204
4204
(7325)
4101
3101
3101
2101
2101
NIOS11
SORT KEY
DL64750
ST22750
QR61250
ZH03500
EV01750
RF59500
AG29750
QH14000
XT59500
GC11090
Z1I52600
ANNUAL ,
PRODUCTION
III
III
(> 105 Ib)
II
(> 103 Ib)
Ih
NAME
2-mercaptobenzothiazole;
MET
N,N'-dlphenyl-l,4-
phenylenedlamlne;
DPPD
nickel acetate;
nickel (II)
acetate
zinc (bls)dlethyldlthlo-
carbamate; Ethyl
ZlmateR; ethyl
zlram
cadmium chloride;
cadmium dichloride
cyclophosphamide
chromic acetate;
chromium (III)
acetate
1-naphthylamlne
N-methyl-N-nltroso-p-
toluenesulfonamlde;
DlazaldR
cobalt (II) nitrate;
cobaltoua nitrate
zinc sulfate .
IARC
REVIEW0
ID
AP
HS
ID
REPORTED USES
Vulcanization accelerator for rubber;
fungicides; corrosion inhibitor In cutting
fluids and petroleum products; additive In
extreme pressure greases
Flex-resistant antloxldant in rubbers;
stabilizer; polymerization inhibitor;
copper degradation retarder; intermediate
for dyes, drugs, plastics, and detergents
Textile mordant; hydrogenatlon
catalyst; (1968 consumption estimated
at over 400,000 pounds)
Rubber vulcanization accelerator,
especially latex foam; heat stabilizer
for polyethylene; (927,000 pounds
produced in 1975)
Production of pesticides, photographic
chemicals, and phosphors; dyeing and
calico-printing of textiles; electronic
vacuum tubes; lubricant ingredient;
manufacture of special mirrors
Proposed as a defleeclng agent for sheep
(currently pending FDA approval); widely
used antlneopiastlc and immunosuppresslve
agent
Textile mordant; tanning agent
HS(C) Dye intermediate; agricultural chemicals;
manufacture of rubber antioxldants;
(2-naphthylamine is a contaminant of
commercial 1-naphthylamlne)
Reagent for the preparation of dlazo-
methane
Sympathetic inks; cobalt pigments; cata-
lysts; additives to soil and animal feeds;
hair dyes; vitamin preparations; porcelain
decoration-(glazes) ... .
Precipitating agent for viscose rayon;
trace nutrient in animal.feeds; fungicide;
fertilizer Ingredient; ore flotation;
water purification; galvanizing
Footnotes: see pp. 47 and 48.
-------
CAS NO.
003129917
001271289
000486259
007446277
000086293
000102772
000155044
000092693
000366187
000592358
000105588
000102090
000120729
000117806
000106149
000141231
OTS
RANK8
4202
4202
4101
4101
3101
3101
3101
3101
3101
3101
3101
3101
3101
(3122)
3101
3101
r 3101
NIOSH
SORT KEY
HY42000
QR65000
LL89250
OG36750
AL98000
DL59500
DL70000
DV58500
DW17500
- EZ01750
FF98000 "
FC05000
NL24500
QL75250
WI38500
WI42000
ANNUAL .
PRODUCTION
(I)
(I)
(I)
(I)
(I)
(I)
<*>
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I) '
NAME
dlcyclohexylamlne
nitrite; dicyc'lo-
hexyl ammonium nitrite
dicyclopentadlenyl nickel;
nlckelocene
9-fluorenone;
fluoren-9-one
lead (II) phosphate;
lead orthophosphate;
CI 77622
diphenylacetonltrile
2- (morphol ino thio ) -
benzothlazole
zinc 2-mercaptobenzothlazole
4-blphenylol ;4-phenylphenol
2,2'-blpyrldlne
n-butyl carbamate
dlethyl carbonate;
ethyl carbonate
dlphenyl carbonate;
phenyl carbonate
indole
dlchlone; 2,3-dlchloro-l,
4-naphthoqulnone
12-hydroxystearlc acid
methyl 12-hydroxystearate
IARC
REVIEW'
AS
AP
REPORTED USES
Corrosion Inhibitor
Catalyst; antiknock agent for'fuels; com-
plexlng agent
Organic research; (originally synthesized as
an experimental insecticide)
Stabilizer in styrene and casein plastics
Preparation of diphenylacetlc acid;
synthesis of antlspasmodics; herbicides
Delayed action vulcanization accelerator
Fubber accelerator; fungicide
Intermediate for dyes; resins; rubber
chemicals; laboratory reagent; fungicide
Reagent for Iron determination
Organic research; (listed In 1971 DCP.
but not In 1975)
Solvent for nitrocellulose, cellulose
ethers, and many synthetic and natural
resins; organic synthesis
Plastlclzer and solvent; synthesis of
polycarbonate resins
Chemical reagent; perfumery
Seed disinfectant; fungicide for foliage
and textiles; insecticides; organic
catalyst
Lithium, greases; chemical intermediates
Adheslves; Inks; cosmetics; greases
Footnotes: see pp. 47 and 48.
-------
CAS NO.
OTS
RANK"
DYES. DYE INTERMEDIATES
000129179 4102
002646175
3101
Minor Commercial Significance (annual production apparently below 1,000 Ib)
NIOSH ANNUAL
SORT KEY
IB91000
QL54250
PRODUCTION NAME
CI Acid Blue 3.sodium
salt; CI 42045
l-(2-tolylazo)-2-
naphthalenol; CI 12100
IARC
REVIEWC
AP
REPORTED USES
Dye
Colorant for oils, varnishes, and waxes;
(dellsted by FDA for use in foods and
drugs)
N>
MISCELLANEOUS
000540738
000062500
000126852
000590965
001615801
000505602
005431334
4303.
(4314)
4204
4202
(4223)
4202.
4101
(4102)
3102
3101
MV26250
PB21000
IA22000
PC26250
MV22750
HQ09000
RK07000
1,2-d taethylhydrazlne;
SDM1I
ethyl methanesulfonate;
EMS
2,2'-dichloro-N-
methyId iethylamlne-N-
oxlde; nitrogen
mustard amlne oxide;
NMO
methylazoxynethanol
1,2-dlethylhydrazlne;
SDEH
bis(2-chloroethyl)
sulfide; mustard gas
glycldyl oleate
AP Experimental rocket fuel; (no known com-
mercial uses)
AP Organic research; considered for use as
reversible male chemosterllants for Insects
and mammalian pests and as possible human
male contraceptive
ID No commercial uses
APJ Metabolite of cycasln (L259500)
AP Experimental rocket fuel; (no known com-
mercial uses)
HS Organic synthesis; tested as an antineoplas-
tic agent; formerly used In chemical warfare
ID Organic research; (no apparent commercial
use
Footnotes: see pp. 47 and 48.
-------
A-2) Pesticides
U>
CAS NO.
000123331
000122349
000083794
000105362
0251682678
000093765
000075605
015879933
0393004538
014484641
000097165
000087865
000133073
000086884
OTS
RANK8
4202
4202
4101
3101
3101
3101
3101
3101
3101
3101
3101
3101
3101
'3101
NIOSH
SORT KEY
UR59500
XY52500
DJ28000
AF60000
AC85750
AJ84000
CH75250
FM94500
CQ57750
N087500
SK91000
SM63000
,TI5685Q
YT92750
ANNUAL
PRODUCTION
NAME
maleic hydrazlde
slmazlne
rotenone
ethyl bromoacetate
Isooctyl 2,4-
dichlorophenoxy-
acetate; 2,4-D
Isooctyl ester
(2,4.5-trichloro-
phenoxy)acetlc acid;
2,4,5-T
dlmethylarslnlc acid;
cacodyllc acid
alplia-chloralose
dinocap
ferric dlmethyldlthlo-
carhamate; ferbam
2,4-dIchloropheny1
benzenesulfonate;
CenlteR
pentachlorophenol;
POP
N-(trlchloromethylthlo)-
. ' phtKalimi.de; folpet ''
alplia-naphthalenylthlourea
IARC
REVIEW0
ID
ID
REPORTED USES
Systemic herbicide; treatment of tobacco
plants; post-harvest sprouting inhibitor;
weed control; sugar content stabilizer in
beets
Herbicide for broadleaf and grassy weeds
Insecticide (toxic to fish); flea powders;
fly sprays; mothproofing agents; (vet.)
grublclde
Pesticide
Herbicide
Plant hormone; herbicide; defoliant
Herbicide, especially for control of Johnson
grass on cotton; soil sterllant; timber
thinning; chemical warfare
Bird repellent on seed grains; Immobilizing
agent to control depredating birds
I
Acarlclde (mlticlde); fungicide
Fungicide
Acarlclde (mlticlde); insecticide
Fungicide; bacterlclde; alglclde; herbicide;
sodium pentachlorophenate; wood preservative
(telephone poles, pilings, etc.)
Funglclde-bactericlde for vinyls, paints and
enamels; protective foliar fungicide on a
wide variety of fruit and truck crops
Rodentlclde . .
" Footnotea: see pp. 47 and 48.
-------
TABLE 4. (SECTIONS B-l AND B-2)
CAS NO.
007220817
0001390S9
.OTS
RANK8
4101
3101
NIOSH
SORT KEY
ANNUAL
PRODUCTION
NAME
B-l) Food-Cosmetic Related Chemicals
AW64750 aflatoxln B2
IARC
REVIEW0
HS
GV73500
sodium cyclamate
REPORTED USES
Naturally occurring fungal byproduct in
foods
Nonnutrltlve sweetener; (use in foods pro-
hibited by FDA)
B-2) Pharmaceuticals
000050282
000053167
000050760
002393535
000052244
* 000130803
000302705
000303344
000057681
000061336
000069578
000050500
000084162
000113382
000063058
000800248
000107697
000604580
006030804
4304
4304
4202
4202
4202
(7313)
4202
4101
(4121)
4101
4101
4101
4101
3203
3203
3202
> . 3101
3101
3101
3101
3101
KC29750
KG85750
AU15750
KG87500
SZ29750
WJ57750
IA22750
OE78750
W092750
XH94000
XH98000
KG40500
SL06000
KC47250
BV81500
DK33250
FD17500
KD71750
KD78750
I beta-estradlol AP
I estrpne AP
actlnomycin D; AP
dactlnomycin
benzoate estrone
thlqtepa; trls- AP
(1-azlrldlnyl)-
phosphlne sulfide
dlethylstllbestrol
dlproplonate
nitrogen mustard AP
N-oxide
lasiocarpine AP
MennethR
penicillin G
sodium penicillin G
estradlol benzoate
hexestrol;
dlhydrodlethyl-
stllbestrol
dlproplonate eatradlol
4-andros tene-3 , 17-d ione
azlridinyl benzoqulnone AP
2,2,2-tricliloroethyl carbamate
~~ . benzoate equllenln
equilin-3-benzoate
Physiologically active isomer of estradlol
(female sex hormone)
Steroid hormone
Antibiotic
Steroid hormone derivative
Antlneoplastlc agent
Synthetic nonsterold compound with estro-
genlc activity
Antlneoplastic agent
Organic research; medicine; (Isolated from
plants)
Antibacterial agent
Antibiotic
Antibiotic; food and feed additive
Estrogen derivative
Nonsterold synthetic estrogen
Estrogen derivative
Androgen (male sex hormone)
Antlneoplastlc agent; organic research
Sedative; hypnotic
Estrogenlc activity
Estrogenlc activity
-------
u»
CAS NO.
000569573
000299296
000056928
000551746
000494031
000057830
000446866
000144821
000058220
*
000066751
OTS
RANK3
3101
3101
3101
3101
3101
3101
(3102)
3101
3101
3101
3101
(4202)
NIOSH
SORT KEY
KV06000
LZ51500
MS15750
OP22750
QM24500
TW01750
U089250
WP08750
XA30300
YQ892SO
ANNUAL .
PRODUCTION NAME
chlorotrianlsene
ferrous gluconate
histamlne dlchlorlde
mannoraustlne dihydro-
chloride; mannltol
mustard dlhydrochloride
N,N-bls(2-chloroethyl)-
2-naphthylamlne
progesterone
arathloprine
sulfamethizole
testosterone
uracil mustard
IARC
REVIEW1
AP
HP
AS
AP
AP
000057910
000050271
2101
2101
KG37500
KC82250
17-alpha-estradiol
estrlol
ID
REPORTED USES
Synthetic nonsterold estrogen
Treatment of anemia; food and feed additive;
vitamin tablets
Medicine
Antlneoplastlc agent
Not uaed in U.S.
Medicine; oral contraceptive; laboratory
reagent
Immunosuppresslve drug
Anti-infective drug
Male eex hormone; biochemical research
Antineoplastic agent
Relatively Inactive Isomer of estradiol
(female sex hormone)
Naturally occurring estrogen .
C) Little or No Information Available Concerning Commercial Importance
000613478
000589413
026630604
000821147
4203
4202
4101
4101
(4122)
NC42000
FB17500
DB26250
KH40250
N-hydroxy-2-naphthylamine
N-hydroxyurethan(e)
N-hydroxy-2-fluorenyl-
benzenesulfonamlde
azoethane
Organic research
Organic research
Organic research
Organic research
Footnotes: see pp. 47 and.48
-------
CAS NO.
016301261
000548936
000551939
004363035
004420795
006810260
006965715
OTS
RANK8
4101
3102
3101
3101
3101
3101
3101
NIOSH
SORT KEY
KH42000
DG26250
AM57750
DV59500
MX42000
NC31500
UF11500
ANNUAL . IARC
PRODUCTION NAME REVIEW0
azoxyethane
2-aolno-3-hydroxybenzolc
acid
; 2-amlnoacetophenone;
2-acetylanlllne
4-amlno-(l,l'-blphenyl)-3-ol
. hydroqulnone mustard
4-hydroxylamlnoblphenyl
2- (2 , 5-d Ichlorophenoxy ) -
005684139 2102
VS30750
proplonlc acid
blsdehydrodolsynollc
acid methyl ester
REPORTED USES
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Organic research
Footnotes: see pp. 47 and 48.
-------
New OTS rank in.parentheses assigned from data contained in Suspected Carcinogens - A Subfile of the Registry
of Toxic Effects of Chemical Substances (2nd Ed.), 1976. [When the route of administration is unknown, the
highest exposure level (2) is assigned.]
Production Key (animal) .
~ = known <103 Ib; production figures available (IARC, EPA/OTS - 1977, or elsewhere)
() » assumed <10 Ib; not listed in the Directory of Chemical Producers (DCP)
(I) - >10 Ib; listed in DCP (no production figures available; however, inclusion in the DCP implies that a chemical has
a production level greater than 1,000 pounds or total sales in excess of $1,000)
I ° >103 Ib; production figures available U.S. International Trade Commission (ITC), IARC, EPA/OTS - 1977,
or elsewhere
II - >10 Ib; production figures available ITC or elsewhere
III » >10 Ib; production figures available ITC or elsewhere
IV » >10 Ib; production figures available ITC or elsewhere
IARC Review: Evaluation of carcinogenlclty data on chemicals as reported by the International Agency for
Research on Cancer (IARC) in their publication IARC Monographs on the Evaluation of the
Carcinogenic Risk to Han (Vols. 1-13)
IIS - Human Positive . '
HS - Human Suspected
AP - Animal Positive
AS - Animal Suspected
ID - Indefinite
(N) - Negative
|(C) - U.S. Occupational Standard-Carcinogen, as determined from NIOSH hazard review documents]
Sources consulted for use Information are listed in References.
Organic research: compounds synthesized as experimental carcinogens or as analogs Co complete a structural
series or class, analytical reagents, or laboratory curiosities.
Combined production of anhydrous hydrazlne and hydrazlne hydrate estimated at 37 million pounds In 1974.
No IARC Review was noted'in the RTECS Subfile (1976); however, the IARC comments note that nickel In f '
some form(s) is carcinogenic to man.
-------
TABLE 4 (continued)
Corrected CAS No.; listed number taken from the TSCA Candidate List of Chemical Substances (April 1977).
.Only one domestic producer reported in 1972; however, Imports of 1-naphthylamlne totaled 59,000 pounds in 1971.
(Occupational'exposure to.commercial 1-naphthylamlne containing 4Z-10X 2-naphthylamine Is strongly associated
with bladder cancer. A number of case reports from several countries support this association. It is not '
possible on present evidence to decide whether 1-naphtlialamine free from the 2-lsomer Is carcinogenic to man
IARC Monograph) . ' ' .
Consumption of zinc sulfate totaled approximately 98,000 pounds In 1971. '
'Ho IARC Review was noted In the RTECS Subfile (1976); however, the IARC Monograph Indicates an AP Review.
i *'.>. * .
AS Review was noted In the RTECS Subfile (1976); however, the IARC Monograph Indicates an ID Review.
The name "urethane" is often applied to high molecular weight "polyurethane" used as foam (Insulation),
elastomers, and'coatings. However, these products are not made from the chemical urethane'and do not
generate It on'decomposition.
R '
Registered trademark.
00
-------
APPENDIX
OTS RANK (FOUR-DIGIT) ASSIGNMENT
In ordering the initial MIOSH Subfile, a four-digit number (ABCD)
was computed for each compound, utilizing data presented in the toxic
dose lines for that compound. Only toxic dose lines that had a car-
cinogenic (CAR) or neoplastic (NEO) response noted were used. For this
effort, CAR and NEO responses were considered equivalent.
The four-digit numbers were computed using the following criteria:
o The first digit, A, represents the species in which a CAR or NEO
response is reported; assignments are:
7: Humans
6: Monkeys
5: Cat, dog, pig, cattle, or domestic animal
4: Rat
3: Mouse .
2: Guinea pig, gerbil, hamster, rabbit, squirrel, or
unspecified mammal -
1: Wild bird, bird, chicken, duck, pigeon, quail, or
turkey
0: Frog
For compounds where CAR or NEO responses are reported in more
than one species, the highest number is assigned.
o The second digit, B, designates the number of different species
for which CAR or NEO responses are reported, to a maximum of 9.
49
-------
o The third digit,, C, designates.^he axlrairiistration route for
which a CAR or NEO response is reported:
2: Inhalation, ocular, or skin application ;;
1: Oral administration v? r"
0: All other routes of administration
Only the highest number is used if CAR or NEO responses are :;
reported for more than one route. ^^,: ;^--
o The final digit, D, is the total number of CAR or NEO responses
reported for this substance, to a maximum of 9; Because the
NIOSH Subfile included only one toxic dose line for any route/
.-- '.:''*
species combination (specifically the.study in which the lowest
effective dose was reported for that combination); this digit is
a count of the number of different route/species combinations
reported to result in, a carcinogenic or neoplastic response, ,
50
-------
The following example illustrates the assignment of this number.
AB94500. ACETAMIDE, N-FLUOREN-2-YL
CAS: 000053963 MW: 223.29 MOLFM: N-0-C15-H13
WIN: L B656 HHJ EMV1
SYN: AAF * 2-AAF * 2-ACETAMIDOFLUORENE * 2-
ACETAMINOFLUORENE * 2-ACETYLAMINO-FLUOREN
(German) * N-ACETYL-2-AMINOFLUORENE * 2-
ACETYLAMINOFLUORENE * AZETYLAMINOFLUOREN
(German) * FAA * 2-FAA * N-2-
FLUORENYLACETAMIDE * N-FLUOREN-2-YLACETAMIDE
TXDS: orl-rat TDLo:475 mg/kg/llWC TXAPA9 18,356,71
TFXrCAR
orl-rat TDLo:300 mg/kg/(9D preg) TCIA** -,121,73
TFXrTER
skn-rat TDLo:260 mg/kg/71WI JNCIAM 10,1201,50
TFXrCAR "
ipr-rat TDLo:192 mg/kg/4WI CNREA8 32,1554,72
TFXrCAR
imp-rat TDLo:22 mg/kg TFXrNEO CNREA8 33,2489,73
orl-mus LD50rl020 mg/kg TXAPA9 25,447,73
orl-mus. TDLor560 mg/kg/14DI BJCAAI 19,297,67
TFXrCAR
par-mus TDLor100 mg/kg/(12D preg) ACATA5 37,239,66
TFXrTER
orl-dog TDLOr2625 mg/kg/25WC CNREA8 10,266,50
TFXrNEO
orl-cat TDLor4344 mg/kg/69WC CNREA8 11,280,51 ,'
TFXrCAR
orl-rbt TDLor4400 mg/kg/65WI PAMIAD 32,177,68
TFXrCAR
ipr-rbt TDLor3600 mg/kg/40WI CNREA8 27,838,67
TFXrNEO
orl-ham TDLor7980 mg/kg/38WC GANNA2 59,239,68
TFXrCAR
itr-ham TDLorlS gm/kg/74W JNCIAM 50,503,73
TFXrCAR'
orl-ckn TDLor2888 mg/kg/13WI BJCAAI 9,163,55
TFXrCAR
STANDARDS & REGULATIONS:
USOS-carcinogen
The order number for this compound is 5729. The first digit (5) is
assigned because a NEO response was reported in the dog; the second
digit (7) is assigned because a CAR or NEO response was reported for
seven different species (rat, mouse, dog, cat, rabbit, hamster, and
chicken); the third digit (2) is assigned because a CAR response was
51
-------
elicited with a skin application of the substance; and the last digit
(9) is assigned because CAR or NEO responses were reported in 12 dif-
ferent route/species combinations (because the maximum allowable is 9,
the last digit defaults to this). ;'..
RATIONALE
The following rationale was used to develop the individual digit
assignment for the initial ordering exercise:
A. For the first digit, a CAR or NEO response reported in humans or
primates indicates evidence or suspicion that the compound is a
human carcinogen. Cats, dogs, etc., are ranked beneath humans
on a phylogenic basis. While the rat and mouse are not phylo-
genically higher than the small mammals ranked beneath them, it
is felt that, because these two species have been studied exten-
sively and their physiological responses to chemical insult are
far better understood, a CAR or NEO response is probably more
meaningful than such a response in a less well studied species.
Between these two species, the rat is given precedence because
it is both better studied and longer Ifved than the mouse.
B. The rationale for the second digit is that a compound shown to
be carcinogenic or neoplastic in two or more species is more
:likely to be universally carcinogenic than a compound for which
the effect has been shown in only one species.
C. The third digit indicates the potential for carcinogenic or
neoplastic response resulting from environmental exposure, in
this respect, responses from inhalation or skin application "are
more indicative of concern for environmental exposure to the
- - 52 - .. \ - - .:.
-------
substance than carcinogenic or neoplastic responses occurring
from injection or implantation. Oral administration is con-
sidered intermediate. ,.
D. The final digit indicates that the CAR or NEO response has been
confirmed both in different species (as in the second digit) and
by different routes of administration within a given species.
The arrangement of the four digits into the ABCD sequence is based.
on the relative significance of each. The first digit is considered
most significant because it indicates the human carcinogenic potential
of the compound. The second digit focuses on the universality of the
response among different species and indicates the likelihood that the
compound has human carcinogenic potential, but to a lesser degree than.
the first digit. The third digit reflects the next most significant- .
parameterthe type of exposure required to elicit the response. The
final digit indicates the degree of confidence about the carcinogenic or
neoplastic response associated with the compound. Due to certain limita-
tions involved in its genesis (for example, many known carcinogens are
studied repeatedly to obtain tumors for further study), the fourth digit
is given the least importance in ordering the compounds.
53
-------
REFERENCES
1. Agranoff, Joan (Ed.), Modern Plastics Encyclopedia, McGraw-Hill, inc., New
York, 1976-77. ;,
2. American Medical Association, Department of Drugs, AMA Drug Evaluations,
3rd ed., Publishing Sciences Group, Inc., Littleton, MA, 1977.\,,
3. Chemical Economics Handbook, Stanford Research Institute, Current edition,
Menlo Park, CA.
4. Chem So.urces-U.S.A.. 19th ed., Directories Publishing Co., Inc., Flemington,
NJ, 1977. ; . . ;
5. Crowley, Ellen (Ed.,h Trade Names Dictionary, Gale Research Co., Detroit,
MI, 1974. '' .- '": , ,i-_';_.
6. Directory of Chemical Producers (1975 & 1977), United States of America
Chemical Information Services, Stanford Research Institute, Menlo Park,
.'.&'".: ' ."/. '
. CA, 1977. : : ;
7. Environmental Protection Agency, Office of Toxic Substances, An Ordering
of the NIOSH Suspected Carcinogens Lists, Based Only on Data Contained '
in the List. EPA 560/1^76-003, NTIS order No. PB-251-851, 1976. i
'':'. ':;'!'
8. Environmental Protection Agency, Office of Toxic Substances, Summary Tabula-
tion of Selected EPA Activities Concerning Toxic Chemicals, EPA 560/4^76^601,
NTIS order No, PB-253-172, 1976. V;
9. Environmental Protection Agency, Office of Toxic Substances, A Study of ^ y .
Industrial Data on Candidate Chemicals for Testing, EPA 560/5-77-006, ;v.
1977. ' - .':., ' .". ;,';'""-. ..v.f /'
10. Environmental Protection Agency, Office of Toxic Substances, Toxic Substances
Control Act (TSCA) PL 94-469: Candidate List of Chemical Substances, ;
VoTs. I-III, GPO-055-007-00001-2, 1977. " -v
11. Freudenthal, R. and Jones, P. (Eds.), Polynuclear Aromatics-Chemical Car-f
cinogenesfs, Raven Press, New York, 1.976.
54
-------
12. Hawley, Gessner, The Condensed Chemical Dictionary, 9th ed., Van Nostrand
Reinhold Co., New York, 1977.
13. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals
to Man, Vols. 1-13, International Agency for Research on Cancer, WHO,
Lyon, France, 1972-1976.
14. International Trade Commission, Synthetic Organic Chemicals, U.S. Produc-
tion and Sales, annual and preliminary reports, 1971-1975, U.S. Inter-
national Trade Commission (formerly U.S. Tariff Commission).
15. Kirk, R.C. and D.F. Othmer, (Eds.), Kirk-Othmer Encyclopedia of Chemical
Technology, 2nd ed., Vols. 1-22, Supplement, John Wiley & Sons, Inc.,.:
New York, 1963-1972.
16. McCurdy, P. (Ed.), Chemical Week 1976 Buyers Guide Issue, October 29,
McGraw-Hill, Inc., New York, 1975. ;;:.'
'; " .' -
17. National Institute of Occupational Safety and Health, Registry of Toxic
Effects of Chemical Substances. U.S. Department of Health, Education,
and Welfare, 1975 and 1976.
18. National Institute of Occupational Safety and Health, Suspected Carcinogens-
A Subfile of the Registry of Toxic Effects of Chemical Substances, .U.S.;
i" .'('."-.'.'
Department of Health, Education, and Welfare, 1975 and 19767
19. OPD Chemical Buyers Directory 1975-1976. Schnell Publishing Co., Inc., ;
1975. ;;
20. Packer, K. (Ed.), Nanogen Index, Nanogens International, Freedom, CA, 1975.
21. Sax, N. (Ed.), Dangerous Properties of Industrial Chemicals, 4th ed., Van ;
Nostrand Reinhold Co., New York, 1975.
22. Windholz, M. (Ed.),' The Merck Index, 9th ed., Merck and Co.,. Inc., Rahway,
NJ, 1976. :
55
-------
23. Wiswesser, W. (Ed.), Pesticide Index, 5th ed., Entomological Society of
America, College Park, MD, 1976.
56
-------
INDEX
NIOSH SORT KEY - A seven character alphanumeric accession number assigned to
each compound listed in the Registry of Toxic Effects of Chemical Substances
(RTECS) or the RTECS Subfile.
NIOSH SORT KEY
AB 40250
AB 94500
AC 07000
AC 57750
AC 59500
AC 66500
AC 71750
AC 73500
AC 89250
AE 42800
AE 70000
AE 71750
AF 60000
AF 85750
A6 29750
AG 85750
AI 52500
AI 89600
AJ 84000
AK 85750
AK 87500
AL 98000
AM 57750
AP 85000
AR 76000
AU 15750
AW 64750
AY 35000
AY 36750
TABLE. SECTION. PAGE
330
3-31
332
329
331
330
332
331
4(A-2)43
4(A-1)39
4(A-1)40
4(A-2)43
4(A-2)43
329
331
4 (A- 1)41
4(C)46<:,
4(B-2)44
4(8-1)44
2(8)26
2(B)26
BA 70000
BP 52500
BQ 43750
BQ 49000
BV 81500
BX 71750
BX 73500
BX 87500
BX 93500
BY 35000
BY 36750
BY 54250
BY 57750
BY 59500
BY 96250
BZ 66500
331
4(B-2)44
1 A)17
3-32
UA)17
330
332
3-32
57
-------
NIOSH SORT KEY
TABLE, SECTION. PA'GE;
BZ 73500
CB 10500
CB 12250
CB 24500
CB 47250
CF 92750
CG 35000
CH 75250
CI 64750
CM 33250
CM 49000
CO 17500
CQ 68250
CU 14000
CU 29750
CV 92750
CW 38500
CW 43750
CW 87500
CW 89250
CX 15750
CX 24500
CY. 03500
CY 10500
CY . 14000
CY 28000
CZ 96250
3-31
3-30
2(B)26
KA)9
2(B)25
1(A)20
4(A-2)43
KA)9
3-31
331
3-32
2(B)26
336
336
3-35
330
330
331
329
330
331
1(A)9
DA 57750
DA 59500
DA 61250
DA 66500
DB 26250
DB 52500
DC 01750
DC 96250
DD 05250
DD 08750
DD. 10500
DD 12250
DD 15750
DD 22750
DD 85750
DE 42000
DF 63000
DF 63500
DG 03500
DG: 12250
DG 26250
DI 57750
DI 82250
2(A)25
4(C)45
T(B) 21
1(A)T3
1(8)21
332
2(A)25
336 :
336
332
4(C)46
335
336
58
-------
NIOSH SORT KEY
TABLE, SECTION, PAGE
DI 94500
DJ 28000
DJ 36750
DO 42000
n.l 7R750
DK i'Oi.'bO
DK 33250
DK 68250
DL 38500
DL 40250
DL 42000
DL 59500
DL 64750
DL 70000
DM 19250
DM 85750
DP 63000
DS 14000
DS 28000
DS 29750
DS 40250
DS 50000
DU 80500
DU 89250
DV 03500
DV 21000
DV 33250
nv .moon
l)V 49UUU
DV 56000
DV 58500
DV ,59500
DV 87500
DW 17500
335
4(A-2)43
336
336
4(8-2)44
3-32
332
332
4(A-1)41
4(A-1)40
4(A-1)41
336
KA)11
333
329
4(A-1)39
KA)17
333
330
KA)17
4(A-1)4T
4(C)46
4(A-1)41
EJ 40250
EJ 52500
EJ 82250
EJ 87500
EK 17500
EL 12250
EO 51000
EO 54250
ER 24500
ES 70000
ES 75250
ET 73500
EU 98500
EV 01750
329
2(8)26
1(A)20
2(B)26
333
333
3-31
UA)11
3-33
2(B)26
1(A)20
4(A-1 )40
59
-------
NIOSH SORT KEY
TABLE. SECTION. PAGE
EY 94500
EZ 01750
EZ 82250
337
4(A-1)41
FA 84000
FB 03500
FB 17500
FC 07000
FC 24500
FC 26250
FG 59500
FC 63000
FD 08750
FD 17500
FD 35000
FD 42000
FD 80500
FD 89250
FD 91000
FF 98000
FG 05000
FG 49000
FM 87500
FM< 94500
FS 91000
FZ 26200
FZ 36750
330
4(C)45
1(8)21
1(A) 14
336
1(8)21
329
K.A)12
4(8-2)44
1(B)22
1(A)20
1(B)22
1(8)22
4(A-1)41
4(A-1 )41
1(A)9
2(8)26
4(A-2)43
336
GB 42000
GB 64700
GB 66500
GC 07000
GG 11090
GH 07000
GN 42000
GQ 57750
GS 60000
GU 71750
GV 35000
GV 43750
GV 49000
GV 71000
GV 73500
GW 46000
GW- 50750
GW 66500
GX 15750
GY 19250
GY 56000
4 (A- 1)39
4(A-1)39
K.AJ14
336
4(A-1 )40
2(B)26
2(B)26
4(A-2)43
1(A)20
333
1 (B)22
1(B)22
1(B)22
2(A)25
4(B-1)44
337
1 CB)21
333
3-^30
333
60
-------
NIOSH SORT KEY
TABLE. SECTION. PAGE
HN 08750
HN 10500
HN 26250
HO 57750
HP 45500
HP 49000
HP 87500
HY 42000
336
336
329
336
337
3-33
333
4(A-1)41
IA 21000
IA 22000
IA 22750
IA 35000
IB 91000
10 17500
10 21000
IQ 05250
2(B)26
4(A-1)42
4(8-2)44
4 (A- 1)42
1(8)21
1(8)21
HA)17
JG 82250
JJ 92750
JJ 95000
JJ 97000
JJ 98000
JO 12250
3-33
KD 71750
KD 78750
KG 29750
KG 37500
KG 40500
KG 47250
KG 82250
KG 85750
KG 87500
KH 40250
KH 42000
KH 57900
KH 78800
KI 07000
KJ 33250
KL 28000
KN 08750
KN 15750
KN 66500
KU 96250
KV 06000
KV 36750
4(8-2)44
4(8-2)44
4(8-2)44
4(8-2)45
4(8-2)44
4(8-2)44
4(8-2)45
4(8-2)44
4(8-2)44
4(C)45
4(C)46
1(8)22
1(8)21
1(8)21
1(8)22
HA 14
KAJ12
330
HA)9
4(8-2)45
333
61
-------
NIOSH SORT KEY
TABLE, SECTION, PAGE
KV 43750
KV 94500
KW 29750
KX 45500
KX 50750
333
1(B)22
1(A)9
LL 50750
LL 54250
LL 69800
LL 89250
LL 91000
LQ 31500
LQ 92750
LT 77000
LU 35000
LV 17500
LZ 51500
LZ 59500
329
333
3^-33
4(A-1)41
333
329
329
2(B)25
1(A)10
332
4(8-2)45
329
MA 10500
MA 12250
MF 22750
MF 42000
MS 15750
MU 10500
MU 17500
MU 71750
MV 22750
MV 24500
MV 26250
MV 28000
MV 29000
MV 56000
MV 80500
MV 96250
MX 35000
MX 42000
1 (B)21
2(B)26
1(A)17
329
4(B-2)45
2(B)25
2(B)25 ,
4(A-1)39
4(A-1)42
4(A-1)42
329
1(A)20
4(C)46
NC 31500
NC 42000
NC 47250
NI 50750
NI 56000
NI 96250
NJ 07000
NJ 08750
NK 79300
4(C)46
4(C)45
2(B)25
2(B)27
333
2(B)25
334
62
-------
NIOSH SORT KEY TABLE. SECTION. PAGE
NL 24500 4(A-1)41
NO 87500 4(A-2)43
NS 03500 2(B)27
NS 17500 2(B)25
NS 22750 2(8)27
OE 78750 4(8-2)44
OF 26250 1(A)11
OF 67300 1(A)17
OF 80500 1(A)16
OF 87500 1(A)14
06 20250 1(A)10
06 36750 4(A-1)41
OL 01750 334
OP 22750 4(8-2)45
OS 10500 1(8)21
OS 91000 1(A)20
OT 01750 1(A)20
PA 70000 330
PB 05250 334
PB 21000 4(A-1)42
PB 26250 : 330
PB 52500 1(A)15
PC 12250 1(8)22
PC 26250 4(A-1)42
PC 28000 331
PC 82250 1(A)18
QE 75250 329
QJ 05250 4(A-1)39
QJ 24500 334
QJ 36750 334
QJ 65300 1(A)12
QJ 65500 1(A)11
QJ 66500 1(A)19
QJ 68250 1(A)13
QK 27050 1(A)12
QL 01750 336
QL 49000 1(A)12
QL 54250 4(A-1)42
QL 59500 1(A)19
QL 71750 1(A)16
QL 75250 4(A-1)41
QM 14000 4(A-1)40
QM 21000 1(A)14
QM 24500 4(8-2)45
63
-------
NIOSH SORT KEY
TABLE. SECTION. PAGE
QM 28500
QM 42000
QM 43750
QM 45500
QM 47250
QR 59500
QR 61250
QR 65000
334
3-34
HA)9
4(A-1 )40
4(A-1)41
RC 89250
RC 89600
RG 15750
RG 94500
RK 07000
RN 77000
RN 85750
RN 86400
RP 54250
RP 59500
RQ 73500
RS 82250
2(8)25
2(B)27
3-36
336
4(A-1)42
336
2(B)26
KA)17
4(A-1)40
1(A)T7
SC 12250
SD 94500
SF 78750
SF 85250
SF 94500
SF 98000
SG 01750
SJ 33250
SJ 77000
SJ 98000
SK 26250
SK 85750
SK 91000
SL 06000
SM 63000
SN 05250
SN 07000
SN 15750
ST 22750
ST 29000
ST 33800
SZ 17500
SZ 19250
SZ 29750
332
3-37
3-34
334
334
1(A)9
1(A) 18
2(8)22
4(A-2)43
4(8-2)44
4(A-2)43
2(B)27
1(A)20
1(8)22
4(A-1)40
1(A)20
1(A)13
4(8-2)44
64
-------
NIOSH SORT KEY TABLE. SECTION. PAGE
TD 08750 1(A)15
TH 75250 334
TI 56850 4(A-2)43
TL 63000 1(A)17
TN 21000 329
TP 45500 4(A-1)39
TQ 13600 1(A)17
TQ 13620 1(A)20
TQ 13720 1(A)20
TQ 13740 1(A)20
TQ 13760 1(A)17
TU 37500 2(B)25
TU 40750 2(8)25
TW 01750 4(8-2)45
TX 49000 1(A)10
UC 07000 1(A)16
UE 78750 1(A)16
UF 11500 4(C)46
UO 89250 4(8-2)45
UQ 05250 332
UR 24500 337
UR 59500 4(A-2)43
UT 22750 334
UT 24500 334
UT 36750 332
UZ 98000 334
VA 12250 337
VB 54250 334
VB 57750 334
VB 59500 335
VB 61250 335
VB 63000 335
VB 71750 335
VB 75250 335
VB 77000 335
VB 98000 330
VC 01750 330
VC 21000 1(A)18
VC 42000 1(A)17
VC 82250 335
VD 19800 335
VD 20000 335
VQ 31500 331
VQ 33250 332
VS 30750 4(C)46
VS 31500 337
65
-------
NIOSH SORT KEY
VT 07000
VT 29750
TABLE. SECTION. PAGE
UA)18
WG 98000
WH 66500
WI 38500
WI 42000
WJ 40250
WJ 56000
WJ 57750
WO 92750
WP 07000
WP 08750
WP 23600
WQ 09000
WR 10500
WS 77000
WS 78750
WS 82250
WT 29750
WW 50750
WZ 03500
WZ 05250
2(B)26
1(8)22
4(A-1)41
4(A-1)41
3-35
4(8-2)44
4(8-2)44
2(8)23
4(8-2)45
2(8)23
4(A-1)42
337
332
1(8)22
4(A-1)39
337
337
XA 30300
XH 94000
XH 98000
XJ 46000
XJ 49000
XJ 50750
XN 08000
XS 43750
XS 47250
XS 80500
XS 96250
XT 59500
XT 70000
XT 86500
XU 28000
XU 29750
XU 88000
XY 21000
XY 26250
XY 52500
XZ 14000
XZ 18000
XZ 21000
XZ 38500
4(8-2)45
4(8-2)44
4(8-2)44
331
331
331
335
337
2(8)23
1(8)21
KA)9
4(A-1)40
337
331
1(A)16
4(A-2)43
2(8)26
1(8)21
66
-------
NIOSH SORT KEY
YK 05250
YR 06000
YR 08750
YR 14000
YR 15750 .
YS 29750
YT 22750
YT 78750
YU 28000
TABLE, SECTION. PAGE
2(8)26
2(8)25
2(8)26
2(8)26
2(8)27
2(8)26
2(A)25
ZE 56000
ZE 57750
ZE 61250
ZE 63000
ZE 64750
ZE 72500
ZH 01750
ZH 03500
ZH 05250
ZH 52600
1(A)20
3-37
4(A-1)40
1(A)10
4(A-1)40
67
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