PUBLICATIONS M1BK ASSESSMENT U.S. Environmental Protection Agency Environmental Criteria and Assessment Office Cincinnati, Ohio January, 1993 ------- TABLE OF CONTENTS SELECTED PUBLICATIONS ON RISK ASSESSMENT - ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE - CINCINNATI Summary iii Publications arranged by author 1-11 Publications arranged by category 12-22 Cancer Risk Assessment 12 Noncancer Risk Assessment 12-14 Mixtures Risk Assessment 14-17 Chemical-specific Risk Assessment 17-19 General Risk Assessment 19-22 Symposia 23-24 ------- SUMMARY The Selected Publications on Risk Assessment is a compilation of the published works of the Environmental Criteria and Assessment Office - Cincinnati scientific staff, this report is arranged into two sections, the first by author and the second by category (i.e. Cancer Risk Assessment, Noncancer Risk Assessment). These sections are followed by a listing of symposia at which ECAO staff presented papers on risk assessment. Currently, there are 149 citations in this listing. Of the 149 citations, 56 are journal articles; 13 are chapters in books; 38 are papers presented at symposia; 39 are EPA reports; and 3 are papers submitted for publication. CONTACT; Erma Durden, Writer-Editor U.S.Environmental ProtectionAgency Environmental Criteria and Assessment Office 26 W. Martin L King Dr. Cincinnati, OH 45268 (513)569-7570 iii ------- SELECTED PUBLICATIONS ON RISK ASSESSMENT (by Author) BARNES, D.G. and M.DOURSON. 1988. Reference dose (RfD): Description and use in health risk assessment. Reg. Tox. Pharm. 8: 471-486. BELCHER, G.D., C.C. TRAVIS and R.F. BRU- INS. 1991. The food chain as a source of human exposure from municipal waste com- bustion: an uncertainty analysis. In: Munici- pal Waste Incineration Risk Assessment. C.C. Travis, ed. Plenum Press, NY. BROWN, K.G. and L.S. ERDREICH. 1989. Statistical uncertainty in the no-observed-ad- verse-effect level. Fund. Appl. Tox. 13:235- 244. BRUINS, R.J.B., L. FRADKIN and J. STARA. 1987. Summary of risk assessment method- ology for municipal sludge reuse or disposal options. Proc. National Conference on Mu- nicipal Sewage Treatment Plant Sludge Man- agement, Boston, MA, May27-29. Hazardous Material Control Research lnst.,SilverSprings, MD. p. 21-24. CHANEY, R., R. BRUINS, D. BAKER, R. KORCAK, J. SMITH and D. COLE. 1987. Transfer of sludge-applied trace elements to the food chain, in: Land Application of Sludge, A.L. Page, T.J. Logan and J.A. Ryan, ed. Lewis Publishers, Inc., Chelsea, Ml. p. 67-99. CHOUDHURY, H., J. COLEMAN, C.T. DeROSA, and J.F. STARA. 1987. Penta- chlorophenol: Health and Environmental Ef- fects Profile. Tox. Ind. Hlth. 2(4): 483-571. CHOUDHURY, H., J. COLEMAN, C.T. DeROSA, and J.F. STARA. 1987. Health and Environmental Effects Profile for Pentachloronitrobenzene. Tox. Ind. Hlth. 3(1): 5-69. CLEVENGER, M.A., R.M. PUTZRATH, S.L. BROWN, M.E. GINEVAN, C.T. DeROSA and M.M. MUMTAZ. 1991. Risk assessment of mixtures: A model based on mechanisms of action and interaction. In: Advances in Risk Anaylsis. Vol.8, Risk Analysis: Prospectsand Opportunity. C. Zeros, ed. Proceedings of the Annual Meeting of the Society for Risk Analy- sis. Held Oct. 30-Nov. 2,1988, Washington, DC. Plenum Press, New York. CLEVERLY, D., R. KELLAM, R. MORRISON, L. FRADKIN, R. BRUINS, P. McGINNIS and N. POSSIEL. 1987. Methodology for the assessment of health risks associated with multiple pathway exposure to municipal waste combustor emissions. Presented at the 80th Ann. Air Pollution Control Assoc. Conf., New York, June 21-26. CLEVERLY, D.H., C.C. TRAVIS and G.E. RICE. 1992. The analysis of indirect expo- sure to toxic air pollutants emitted from station- ary combustion sources: a case study. Pre- sented at the 85th Annual Meeting of the Air & Waste Management Association, June 21 -26, 1992, Kansas City, MO. CRUMPLER, E.P. and L. FRADKIN. 1987. Risk assessment in development of municipal sludge incineration regulations under 405(d) of the Clean Water Act. Proceedings National Conference on Municipal Sewage Treatment Plant Sludge Management, Boston, MA, May 27-29. Hazardous Material Control Research Inst., Silver Springs, MD. p. 30-35. DAWSON, G.W., C.J. ENGLISH and L. FRADKIN. 1988. The regulation of sludge disposal through application of risk assess- ment techniques. Presented at the U.S. EPA/ ASTM Symp. Chemical and Biological CharacterizationofMunicipal Sludges,Sediments,Dredge Spoils and Drill- ing Muds, Cincinnati, OH, May 20-22. 1 ------- DeROSA, C.T., H. CHOUDHURY and W.B. PEIRANO. 1991. An integrated expsoure and pharmacokinetic based approach to the assessment of complex exposures lead: a case study. Tox. Ind. Hlth. 7(4): 321-248. DeROSA, C.T., M.L. DOURSON and R. OSBORNE. 1989. Risk assessment initiative for noncancer endpoints: Implications for risk characterizations of chemical mixtures. Tox. Ind. Hlth. 5(5): 805-824. DeROSA, C.T., J. STARA and P. DURKIN. 1985. Ranking chemicals based on toxicity data. Tox. Ind. Hlth. 1:177-199. DOURSON, M.L. 1984. Toxicity-based meth- odology, thresholds and possible approaches, and uncertainty factors. Jn: Approaches to risk assessment for multiple chemical expo- sures. EPA600/9-84-008. p. 2-42. DOURSON, M.L. 1984. Health risk assess- ment for less-than-lifetime chemical exposure. In: Selected Approaches to Risk Assessment for Multiple Chemical Exposures: Progress Report on Guideline Development at ECAO- Cin., J.F. Stara and L.S. Erdreich, Ed. U.S. EPA, Cincinnati, OH. EPA 600/9-84/014a. p. 9-15. DOURSON, M.L. 1986. New approaches in the derivation of the acceptable daily intake (ADI). Comments Toxicol. 1: 35-48. DOURSON, M.L. 1991. Overview of EPA's quantitative noncancer guidelines. Air and Waste Management Association. For Pre- sentation at the 84th Annual Meeting & Exhi- bition Vancouver, British Columbia, June 16- 21,1991. DOURSON, M.L. and J.M. BAXTER. 1981. Reduced incidence and growth rate of ure- thane induced lung adenomas in aging adult strain A mice. Toxicology. 20:161-178. DOURSON, M.L. and J.M. CLARK. 1990. Fish consumption advisories: Toward a uni- fied, scientifically credible approach. Reg. Tox. Pharm. 12:165-172. DOURSON, M.L. and C.T. DeROSA. 1991. The use of uncertainty factors in establishing safe levels of exposure, in: Statistics in Toxicology. Ed., D. Kreski and C. Franklin. Gordon and Breach Science Publishers, New York, NY. DOURSON, M.L., R. HERTZBERG, R. HARTUNG and K. BLACKBURN. 1985. Novel methods for the estimation of accept- able daily intake. Tox. Ind. Hlth. 1(4):23-33. DOURSON, M.L., R.C. HERTZBERG and J.F. STARA. 1986. Letters to the Editor. Fund. Appl. Tox. 6:182-184. DOURSON, M.L. and W. L. JORDAN. 1989. How "safe" is ground water Americans drink? GWMR. Fall: 73-74. DOURSON, M.L., L. KNAUF and J. SWARTOUT. 1991. On reference dose (RfD) and its underlying toxicity data base. Tox. Ind. Hlth. 8(3): 171-189. DOURSON, M.L. and E.J. O'FLAHERTY. 1982. Relationship of lung adenoma preva- lence and growth rate to acute urethane dose and target cell number. J. Nat. Can. Inst. 69(4): 851-857. DOURSON, M.L. and J. STARA. 1983. Regu- latory history and experimental support of un- certainty (safety) factors. Reg. Tox. Pharm. 3: 224-238. DOURSON, M.L., B. STERN, S. GRIFFIN, and K. BAILEY. 1991. Impact of risk-related concerns on U.S. Environmental Protection Agency Prog rams. In: Nitrate Contamination: Exposure, Consequence and Control. I. Bogardi and P.O. Kuzella, ed. NATO ASI Series. Series G: Ecological Sciences, Vol. 30. ------- DU, J.T., S.F. VELAZQUEZ and C. SONICH- MULLIN. 1991. Risk assessment of manga- nese (Mn) in drinking water. The 1991 Annual Meeting of the Society of Toxicology. Held at Loews Anatole Hotel, Dallas, Texas, February 25-March 1,1991. ERDREICH, L.S. 1983. Comparing epidemiologic studies of ingested asbestos for use in risk assessment. Env. Hlth. Persp. 43:99-104. ERDREICH, L.S. 1988. Combining animal and human studies. Resolving conflicts, sum- marizing the evidence. IQ: Epidemiology and Health Risk Assessment, L.Gordia, ed. Ox- ford University Press. ERDREICH, L.S. 1985. Epidemiologic data for health risk assessment. Am. J. Epidem. 122(3): 551 (abstract). ERDREICH, L.S. and C. BURNETT. 1985. Improving the use of epidemiologic data in health risk assessment. Tox. Ind. Hlth. 1:65- 81. ERDREICH, L.S. and E. LEE. 1981. Use of relative operating characteristic analysis in epidemiology. Am. J. Epidem. 114(5): 649- 662. ERDREICH, L.S. and C. SON1CH-MULLIN. 1984. Hypersusceptible subgroups of the population in multiple chemical risk assess- ment. IQ: Approaches to Risk Assessment of Multiple Chemical Exposures, J.F. Stara and LS. Erdreich, Ed., U.S. EPA, Cincinnati, OH. EPA 600/9-84-008. ERDREICH, L.S. and C. SONICH-MULLIN. 1984. Health assessment of exposures to chemical mixtures: Subpopulations at Greater Risk. IQ: Approaches to Risk Assessment for Multiple Chemical Exposures. EPA 600/9-84- 008. FARLAND, W. and M.L. DOURSON. 1992. Noncancer Health Endpoints: Approaches to quantitative risk assessment, (in press) FARREN, B. and R. HERTZBERG. 1986. The STARAToxicity Data Base. Environmen- tal Research Brief. U.S. EPA. Office of Health and Environmental Assessment, Environmen- tal Criteria and Assessment Office, Cincinnati, OH. EPA600/M-86-016. FAROOQUI, M.Y.H. and M.M. MUMTAZ. 1990. Toxicology of methacrylonitrile. Toxi- cology 65: 239-250. FAROOQUI, M.Y.H., MM. MUMTAZ, B.I. GHANAYEM and A.E. AHMED. 1990. He- moglobin degradation lipid peroxidation, and inhibition of Na/K+-ATPase in rat erythrocytes exposed to acrylonitrile. J. Bio. Tox. 5(4): 221 - 227. FRADKIN, L, R. BRUINS, S. LUTKENHOFF, J. STARA, E. LOMNITZand A. RUBIN. 1987. Screening methodology for assessing poten- tial health effects from municipal sludge incin- erators. J. Air Poll. Con. Assoc. 37:395-399. FRADKIN, L, R. BRUINS, B. PEIRANO, S.LUTKENHOFF, J. STARA, G. DAWSON and J. ENGLISH. 1986. Risk assessment methodology for determining groundwater contamination from landfilling sludge. IQ: Proc. American Society of Civil Engineers s(ASCE) Environmental Engineering Conf., Cincinnati, OH, July 8-10,1986. FRADKIN, L., C. GERBA, S. GOYAL, P. SCARPINO, R. BRUINSand J. STARA. 1989. Potential public health concerns from patho- gens in municipal wastewater sludge. J. Env. Hlth. 51 (3): 148-152. ------- FRADKIN, L., T. HARTLAGE, R. HARLESS, J. WALLINGS and D. CLEVERLY. 1988. Multimedia, multipollutant field study to estab- lish levels of toxic contaminants in air, soil, sediment, waterand agricultural products from a model municipal waste combustor. Pre- sented at the 1988 EPA/APCA Symposium on Measurement of Toxic and Related Air Pollut- ants, Raleigh, NC. May 1-4,1988. FRADKIN, L, N. KOWALand P. SCARPING. 1987. Multi-media microbiological risk as- sessment methodology for municipal waste- water sludges. Proc. National Conference on Municipal Sewage Treatment Plant Sludge Management. Boston, MA, May 27-29. Haz- ardous Material Control Research Inst., Silver Springs, MD. p.25-29. FRADKIN, L., S. LUTKENHOFF, J. STARA, E. LOMNITZand B. CORNABY. 1985. Fea- sibility for performing and risk assessment on pathogens. J. Water Poll. Con. Fed. 57:1183- 1188. GHANAYEM, B., M.Y.H. FAROOQUI, O. ELSHABRAWY, M. M. MUMTAZ and A.E. AHMED. 1991. Assessment of the acute acrylonitrile-induced neurotoxicity in rats. Neurotox. and Terat. 13: 499-502. GREIFE, A, R. SCHOENY and D. WARSHAWSKY. 1986. Alveolar macroph- age metabolism of benzo-a-pyrene in the pres- ence of the cocarcinogen ferric oxide. Sev- enty-seventh Annual Meeting of the American Association for Cancer Research, Los Ange- les, Calif., USA< May 7-10, 1986. Proc. Am.Assoc. Cancer Res. Annu. Meet. 27(0): 118. GREIFE, A., R. SCHOENY and D. WARSHAWSKY. 1988. Effect of the cocarcinogen ferric oxide on benzo(a)pyrene metabolism by hamster alveolar macrophages. In: Polynuclear Aromattic Hydrocarbons: A Decade of Progress. M.Cooke and A. J. Dennis.ed. Tenth International Syposium, Battelle Press, Columbus, OH., pp. 317-327. GUTH, D.J., A.M. JARABEK, L. WYMER, R.C. HERTZBERG. 1991. Evaluation of risk assessment methods for short-term inhalation exposure. Presentation at the 84th Annual Meeting of the Air & Waste Management As- sociation, June 16-21,1991, Vancouver, Brit- ish Columbia. HATTIS, D., L ERDREICH and M. BALLEW. 1987. Human variability in susceptibility to toxic chemicals - a preliminary analysis of pharmacokinetic data from normal volunteers. Risk Analysis. 7(4): 415-424. HERTZBERG, R.C. 1984. Use and biological justification of mathematical models, la: Se- lected Approaches to Risk Assessment for Multiple Chemical Exposures: Progress Re- port on Guideline Development at ECAO-Cin, J.F. Stara and LS. Erdreich, Ed., U.S. EPA, Cincinnati, OH. EPA 600/9-84-014a. HERTZBERG, R.C. 1984. Risk assessment for less-than-lifetime exposure. In: Selected Approaches to Risk Assessment for Multiple Chemical Exposures: Progress Report on Guideline Development at ECAO-Cin, J.F. Stara and LS. Erdreich, Ed., U.S. EPA, Cin- cinnati, OH. EPA 600/9-84-008. HERTZBERG, R.C. 1988. Studies on toxicity applicable to risk assessment (STARA) user's guide. Quantitative toxicity data and graphics on environmental chemicals. Environmental Criteria and Assessment Office, U.S. EPA, Cincinnati, OH. February, 1988. HERTZBERG, R.C. 1989. Fitting a model to categorical response data with application to special extrapolation to toxicity. Health Phys- ics. 57(Suppl. 1): 404-409. HERTZBERG, R.C. 1992. Studies on toxicity of mixtures and interacting chemicals user's guide. (MIXTOX) U.S. EPA, Environmental Criteria and Assessment Office, Cincinnati, OH. 45268. Available on diskette. ------- HERTZBERG, R.C. 1991. Quantitative ex- trapolation of toxicological findings. In: Statis- tics in Toxicology. D. Krewski and C. Franklin, ed. Gordon and Breach Science Publishers. New York, NY. HERTZBERG, R.C. and T. CLARKSON. 1984. Interspecies conversion of dose and duration exposure - noncarcinogenictoxicants. in: Selected Approaches to Risk Assessment for Multiple Chemical Exposures: Progress Report on Guideline Development at ECAO- Cin, J.F. Stara and L.S. Erdreich, Ed. U.S. EPA, Cincinnati, OH. EPA 600/9-84-014a. HERTZBERG, R.C. and P. DURKIN. 1984. Multiple chemical assessment. in: Selected Approaches to Risk Assessment for Multiple Chemical Exposures: Progress Report on Guideline Development ECAO-Cin, J.F. Stara and L.S. Erdreich, Ed. U.S. EPA, Cincinnati, OH. EPA 600/9-84/0143. HERTZBERG, R.C. and M. MILLER. 1985. A statistical model for species extrapolation us- ing categorical response data. Tox. Ind. Hlth. 1:43-57. HERTZBERG, R.C. and J. PATTERSON. 1987. Approaches to the quantitative estima- tion of health risk from exposure to chemical mixtures. Proceedings of the Twenty-fourth Hanford Life Sciences Symposium on Health and Environmental Research on Complex Organic Mixtures. Oct. 20-24,1985, Richland, Washington. HERTZBERG, R.C. and L. WYMER. 1991. Modeling the severity of toxic effects. Air & Management Association. In: Proceedings papers from the 84th Annual Meeting and Exhibition, June 16-21, 1991, British Colum- bia. Air and Waste Management Association. HILL, R.N., L.S. ERDREICH, O.E. PAYNTER, P.A. ROBERTS, S.L. ROSENTHALand C.F. WILKINSON. Thyroid follicular cell carcinogenesis. Fund. Appl. Tox. 12: 629- 697. JARABEK, A.M., M.G. MENACHE, J.H. OVERTON, Jr., M.L. DOURSON, and F.J. MILLER. 1989. Inhalation Reference Dose (RfD): An application of interspecies dosim- etry modeling for risk assessment of insoluble particles. Health Physics. 57(Suppl. 1): 177- 183. JARABEK, A.M., M.G. MENACHE, J.H. OVERTON, Jr., M.L. DOURSON and F.J. MILLER. 1990. The U.S. Environmental Protection Agency's inhalation RfD methodol- ogy: Risk assessment for air toxics. Tox. Ind. Hlth. 6(5): 279-301. KOOYOOMIJIAN, J., C. DeROSA, and M. CHU. 1986. The use of potential carcinoge- nicity and chronic toxicity primary criteria for RA. In: Proc. 1986 Hazardous Waste Spills Conf., St. Louis, MO, May 5-8. KOWAL, N.E., R.J.F. BRUINS and C. SONICH-MULLIN. 1989. Overview of risk assessment for toxic and pathogenic agents. Proceedings: Water Quality Technology Con- ference, American Water Works Association. Held in Philadelphia, PA., November 12-16, 1989. p. 905-919. LEE, S.D., D. MUKERJEE, et al. 1983. As- sessment of benzene health effects in ambi- ent water. IQ: Advances in Modern Environ- mental Toxicology, Vol. 4. Carcinogenicity and Toxicity of Benzene. M.A. Mehlman, ed. Chapters, p. 91-125. LOMNITZ, E., R. BRUINS and L. FRADKIN. 1985. Screening chemicals in municipal slud- ges. Biocycle 26: 52-54. LOPER, J.C., D.R. LANG, R.S. SCHOENY, B.B. RICHMOND, P.M. GALLAGHER and C.C. SMITH. 1978. Residue organic mixtures from drinking water show in vitro mutagenic and transforming activity. J.Tox. Env. Hlth. 4(5-6): 919-938. ------- LU, F.C., and M.L. DOURSON. 1992. Safety risk assessment of chemicals: principles, pro- cedures and examples. J. Occ. Med. Tox. 1(4) :321-335. LUTKENHOFF, S., R. HERTZBERG, C. SONICH-MULLIN. 1988. Applicability of U.S. EPA risk assessment guidelines for chemical mixtures. IQ: Trace Substances in Environ- mental Health-XXII, Proc. University of Missouri's 22nd Ann. Conf. TRace Substances in Environmental Health, St. Louis, Missouri, May 23-26. MEYLAN, W., L. PAPA, C.T. DeROSA and J.F. STARA. 1986. Chemical of current interest propylene oxide: Health and Environ- mental Effects Profile. Tox. Ind. Hlth. 2(3): 219-260. MUKERJEE, D. and D. H. CLEVERLY. 1987. Riskfrom exposure to polychlorinated dibenzo- p-dioxins and dibenzofurans emitted from municipal incinerators. Waste Management and Research 5: 269-283. MUKERJEE, D., and D. H. CLEVERLY. 1987. Strategies for assessing risk from exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans emitted from municipal incin- erators. Waste Management and Research 5: 269-283. (Please note: this paper was discussed exten- sively in an editorial in BioCycle 29(2): 58-59, 1988.) MUKERJEE, D., C. DeROSA and J.F. STARA. 1987. 2,3,7,8-tetrachlorodibenzo-p- dioxina: (in Spanish). Published by Centro Panamericano de Ecologia Humana y Salud. Organizacion Panamericana de la Salud. MUKERJEE, D. L. FRADKIN and D.H. CLEV- ERLY. 1988. Multimedia impact of chlroinated polycyclic hydrocarbon emission from com- bustion sources. Proc. Dioxin - 8th. Interna- tional Synmposium of chlorinated dioxins and related compounds, p. 330. MUKERJEE, D, S. MUKERJEE and T.J. POWERS. 1991. Sanierungspraxisin den USA. In: Herausforderung. Herausgeber: G. Albracht, O.A.Schwerdtfeger. Verlag: Universum Verlagsanstalt GmbH KG, Wiesbaden. (No English translation available). MUKERJEE, S., D. MUKERJEE, T. J. POW- ERS and O.WASSERMANN. 1991. Strategy to reduce risk of asbestos in the United States. J. Clean Tech. Env. Sci. 1(324): 193-207. MUKERJEE, D., O. PAPKE and W. KARMAUS. 1988. Indoor Air Contamination with Polychlorinated Dibenzo-p-dioxins and Dibenzofurans. Tox. Ind. Hlth. 2(3): 219-260. MUKERJEE, D., S. QUE HEE and O. WASSERMANN. 1990. Rationale for consid- ering PCB mixture as carcinogenic in risk assessment. Proc. Dioxin '90. MUKERJEE, D. and J.F. STARA. 1981. Asbestos and its threats. Chemical Week 129:5. MUKERJEE, D. and J.F. STARA. 1982. Rationale for quantitative risk assessment for carcinogens at uncontrolled hazardous waste sites. Proceedings of the XIII International Cancer Congress. Statistical Issues in Can- cer Etiology and Survival. Held in Seattle, Washington, September 8-15. p. 35. MUKERJEE, D. and J.F. STARA. 1983. Rationale for developing criteria for carcino- gens. Proc. 76th Ann. Meeting - Air Pollution Control Association. Held in Atlanta, Georgia, June 19-24,1983. p. 1-8. MUKERJEE, D., J.F. STARA, C.H. RIS and J.L. SCHAUM. 1985. Rationale for assess- ment of risk from exposure to 2,3,7,8-TCDD. Proc. of Dioxin 85 - 5th Int'l Symposium on Chlorinated Dioxins and Related Com- pounds. Held in Bayreuth, West Germany, September 16-19,1985. Chemosphere. 15:9-12,1986. ------- MUKERJEE, D., J.F. STARA and J.L. SCHAUM. 1986. Rationale for assessment of risk from exposure to 2,3,7,.8-TCDD. Chemo- sphere. 15(9-12): 1805-1813. MUKERJEE, D. and O. Wassermann. 1990. Rationale for risk assessment of environmen- tal carcinogens. Proc. XIX Congreso Lationamericano de Quimica. MUMTAZ,M.M.andP.DURKIN. 1992. Regu- latory approaches and problems in risk as- sessment of chemical mixtures. In: Toxicol- ogy of Chemical Mixtures: from real life ex- amples to mechanisms of toxicologic interac- tions, R. Yang, ed. (in press) MUMTAZ, M.M., M.Y.H. FAROOQUI, B.I. GHANAYEM and A.E. AHMED. 1991. The urotoxic effects of N,N'- Dimethylaminopropionitrila. 2. In vivo and in vitro metabolism. Tox. Appl. Pharm. 110:61- 69. MUMTAZ, M.M., M.Y.H. FAROOQUI, B.I. GHANAYEM, S. RAJARAMAN, L. FRANKENBERG, and A.E. AHMED. 1990. Studies on the mechanism of urotoxic effects of N.N'-Dimethylaminopropionitrile in rats and mice. 1. Biochemical and morphologic char- acterization of the injury and its relationship to metabolism. J. Tox. Env. Hlth. 33:1-17. MUMTAZ, M.M. and R.C. HERTZBERG 1992. The status of interactions data in risk of chemical mixtures. In: Hazard Assessment Chemicals, Vol. 8. J. Sexena, ed. Hemi- sphere Publishing Co., Washington, D.C. (in press) MUMTAZ, M.M., D.L. McKEAN, R.J. BRU- INS, R.S. SCHOENY and C.T. DeROSA. 1991. Research strategy for risk characteriza- tion of complex exposures. Proceedings of the Fourth International Conference on the Combined Effects of Environmental Factors. Held in Baltimore, Maryland Sept. 30,1990 - Oct.3, 1990. Published by Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland. MURPHY, P.A. 1990. Avoiding bias: system- atic and random error, in: Methods for the Investigation and Prevention of Waterborne Disease Outbreaks. G.F. Craun, ed. Health Effects Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH. MURPHY, P.A. and G.F. CRAUN. 1989. A review of recent epidemiologic studies report- ing associations between drinking water Chlo- rination disinfection and cancer. In: Water Chlorination - Chemistry, Environmental Im- pact and Health Effects. Vol 6. Proceedings of the Sixth Conference on Water Chlorina- tion: Environmental and Health Effects, Oak Ridge, Tennessee, May 3-8, 1987. Lewis Publishers. NEWMAN, M.A., S.Q. HEE, R. SCHOENY and L LOWRY. 1990. Biological monitoring screening of patients provided antineoplastic drugs including adriamycin, cyclophospha- mide, 5-fluorouracill, methotreaxate, and vincristine. Cancer Res. June 1; 50(11): 3351-66. NEWMAN, M.A., S.S. HEE and R.S. SCHOENY. 1990. Mutagenesis assays on urines produced by patients administered adriamycin and cyclophosphamide. Env. Mol. Mut. 16(3): 189-203. O'FLAHERTY, E.J. and M.L. DOURSON. 1982. Relationship between urethane dose rate and adenoma latency: relevance of tumor growth rate and target cell number. J. Nat. Can. Inst. 69(4): 859-865. O'FLAHERTY, E.J. and M.L. DOURSON. 1983. A reply to the letter to the Editor" Cells of Origin of Lung Tumors in Mice". J. Nat. Can. Inst. 70(6): 991-992. ORME, J. E. OHANIAN, L. PAPA and C. SONICH-MULLIN. 1989. Advantages and disavantages of drinking water disinfectant. In: Trace Substances in Environmental Health. Vol. 23:247-257. ------- PATTERSON, J., R. SCHOENY and P. DAUNT. 1991. The U.S. Environmental Pro- tection Agency's Integrated Risk Information System (IRIS), in: Regulating Drinking Water Quality. C. Gilbert and E. Calabrese, ed. Lewis Publishers, Inc., Chelsea, Michigan. POIRIER, K.A. and S.F. VELAZQUEZ. 1991. Risk assessment of manganese: a compari- son of oral and inhalation derivations. 75th Annual Meeting of the Federation of American Societies for Experimental Biology, Atlanta, GA. April 21-25. FASEB 5(4): A486. RICE, G.E. and R.J.F. BRUINS. 1991. Indi- rect exposure: a comparison of two method- ologies. In: Proceedings of the 1991 National Solid Waste Forum on Integrated Municipal Waste Management. Held July 15-17,1991, Flamingo Hilton Hotel, Las Vegas, Nevada. Sponsored by the Association of State andTerritorial Solid Waste Management Offi- cials. Washington, DC. RYAN, J.J., D. MUKERJEE et al. 1987. Estimation of total body burden of PCDFs associated with chloracne in humans based ontheYushoand Yucheng poinsonings. Proc. 7th Interntaional Sumposium on Chlorinated Dioxins and related compounds. Vo. I. Hto3. SCARPING, P., L. FRADKIN, C. CLARK, N. KOWAL, E. LOMNITZ, M. BASEHEART, J. PETTERSON, R.L. WARD and M. HESFORD. 1988. Microbiological risk assessment for land application of municipal sludge. Pre- sented at the U.S. EPA/ASTM Symposium on Chemical and Biological Characterization of Municipal Sludges, Sediments, Dredge Spoils and Drilling Muds, Cincinnati, OH, May 20-22. SCHOENY, R.S. 1982. Mutagenicity testing of chlorinated biphenyls and chlorinated dibenzofurans. Mut. Res. Mar.; 101(1): 45- 56. SCHOENY, R.S. 1990. U.S. Environmental Protection Agency processes for consensus building for hazard identification, in: Pesticide Residues and Food Safety - A Harvest of Viewpoints. B.G. Tweedym H.J. Dishburger, LG. Ballantine and J. McCarthy. ACS Sym- posium Series 446. SCHOENY, R., T. CODY, D. WARSH AWSKY and M. RADIKE. Metabolism of mutagenic polycyclic aromatic hydrocarbons by photo- synthetic algal species. Mut. Res. Feb.; 197(2): 289-302. SCHOENY, R.S. and E. MARGOSCHES. 1989. Evaluating comparative potencies: developing approaches to risk assessment of chemical mixtures. Tox. Ind. Hlth. 5(5): 825- 837. SCHOENY, R.S., J. PATTERSON, J. SWARTOUTandL.TUXEN. 1989. The U.S. Environmental Protection Agency's Integrated Risk Information System. Proceedings of the 5th International Conference on Environmen- tal Mutagens. Held in Cleveland, Ohio, July 10-15, 1989. Prog. Clin. Biol. Res. 340D: 1- 387, 1990. SCHOENY, R., D. WARSHAWSKY, L. HOLLINGSWORTH, M. HUND and G. MOORE. 1981. Mutagenicity of products from coal gasification and liquefaction in the Salmonella/microsome assay. Env. Mut. 3(2): 181-95. SONICH-MULLIN and L.R. PAPA. 1990. Health risk and assessment issues associ- ated with the regulation of drinking water dis- infectants and disinfectant by-products. Trace Substance and Environmental Health. Vol 24: 220-233. STARA,J.F. 1989. First generation of an new science: risk assessment in transition. Tox. Ind. Hlth. 5(5): 621-627. 8 ------- STARA, J., M. DOURSON and D. DeROSA. 1980. Water Quality Criteria: applications, in: Conference Proceedings on Environmental Risk Assessment: How New Regulations will Affect the Utility Industry. Held in New Or- leans, Louisiana, Dec. 10-11,1980. Prepared forthe Electric Power Research Institute, Palo Alto, CA. STARA, J.F., R.C. HERTZBERG, R. J.F. BRU- INS, M.L. DOURSON, R.P. DURKIN, L.S. ERDRIECH and W.E. PEPELKO. 1985. Ap- proaches to risk assessments of chemical mixtures. In: Karger Continuing Education Series Vol. 8: Safety Regulation of Chenmicals inthe U.S.A. S. Karger AG: Basel. STARA, J.F., D. MUKERJEE, R. McGAUGHY, P. DURKIN and M. DOURSON. 1983. The current use and studies on promot- ers and cocarcinogens in quantitative risk as- sessment. Env. Hlth. Persp. 50: 359-368. STARA, J., J. PATTERSON, K. BLACKBURN, R. HERTZBERG and C. DeROSA. 1985. Health risk assessment of chemical mixtures. In: Trace Substances in Environmental Health - XIX, D. Hemphill, Ed. 19th Ann. Conf. Trace Substances in Environ- mental Health, Columbia, MD, June 3-6.1985. STARA, J.F., J. PATTERSON and M.L. DOURSON. 1986. Risk assessment ap- proaches for ground water contamination by pesticides and other organic substances. ACS Symposium organic substances. ACS Sym- posium Series: Evaluation of Pesticides in Ground Water. W.Y. Garner, R.C. Honecycutt, H.N. Nigg, ed. American Chemical Society, Washington, DC. U.S.EPA. 1980. Appendix C. Guidelines and methodology used in the preparation of health effects assessment chapters of the consnet decree water criteria documents. Fed. Reg. 45: 79347-79357. U.S. EPA. 1984. Approaches to risk assess- ment for multiple chemical exposures. J.F. Stara and L.S. Erdreich, ed. Cincinnati, OH. EPA 600/9-84-008. NTIS PB84-1B2369. U.S.EPA. 1984. Selected approaches to risk assessment for multiple chemical exposures: progress report on guideline development at ECAO-Cin. J.F. Stara and L.S. Erdreich, ed. Cincinnati, OH. EPA 600/9-84-014a. NTIS PB84-226992. U.S.EPA. 1986. Development of a qualitative pathogen risk assessment methodology for municipal sludge landfilling. Office of Health and Environmental Assessment, Environmen- tal Criteria and Assessment Office, Cincinnati, OH. NTISPB88-198544/AS.) U.S. EPA. 1986. Health effects assessment documents. 1986. Project Summary. Epa/ 540/S1-86/059. U.S.EPA. 1986. Workshops for the develop- ment of methodology for health risk assess- ment. Office of Health and Enviromental As- sessment. Environmental Criteria and As- sessment Office. U.S. EPA/ Cincinnati, OH. Project Summary. EPA 600.S9-85027. U.S. EPA. 1987. The risk assessment guide- lines of 1986. Office of Health and Environ- mental Assessment, Washington, DC. EPA 600/S9-85-027. U.S. EPA. 1987. Health assessment docu- ment for carbon tetrachloride. Project Sum- mary. EPA/S8-82/001F. U.S. EPA. 1987. Human variability in suscep- tibility to toxic chemicals -!. Noncarcinogens. Office of Health and Environmental Assess- ment, Environmental Criteria and Assessment Office, U.S. EPA, Cincinnati, OH. Project Summary. EPA 600/S8-86-033. ------- U.S. EPA. 1988. Issues on review in ECAO. Office of Health and Environmental Assess- ment, Environmental Criteria and Assessment Office, Cincinnati, OH. U.S. EPA 1988. Reference dose (RfD): De- scription assessments. Integrated Risk Infor- mation System (IRIS). Intra-Agency Refer- ence Dose (RfD) WorkGroup, Office of Health and Environmental Assessment, Environmen- tal Criteria and Assessment Office, Cincinnati, OH. February. U.S. EPA. 1988. EPA approach for assessing the risks associated with chronic exposures to carcinogens. Integrated Risk Information Sys- tem (IRIS). Online. Intra-Agency Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH. February. U.S.EPA. 1988. Office of drinking water health advisories. Integrated Risk Information Sys- tem (IRIS). Online. Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH. February. U.S.EPA. 1988. Development of a qualitative pathogen risk assessment methodology for municipal sludge landfilling. Project Sum- mary. EPA 600/S6-88/006. U.S. EPA. 1988. Health assessment docu- ment for polychlorinated dibenzo-p-dioxins. Project Summary. EPA600/S8-84/014F. U.S. EPA. 1988. Recommendations for and documentation of biological values for use in risk assessment. Project Summary. EPA 6007 S6-876/008. U.S. EPA. 1989. Interim methods for devel- opment of inhalation references doses. EPA/ 600/8-88/006F. August. U.S. EPA. 1989. Statistical methods for estimating risk for exposure above the refer- ence dose. Environmental Criteria and As- sessment Office, Cincinnati, OH. U.S.EPA. 1989. Development of risk assess- ment methodology for land application and distribution and marketing of municipal sludge. EPA/600/6-89/001. U.S.EPA. 1989. Development of risk assess- ment methodology for municipal sludge landfilling. EPA600/6-90/008. U.S.EPA. 1989. Pathogen risk assessment for land application of municipal sludge, Vol. 1: Methodology and computer model. EPA 600/ 6-90/002A. U.S. EPA. 1989. Pathogen risk assessment for land application of municipal sludge, Vol. 2: User's manual. EPA 600/6-90/002B. U.S.EPA. 1990. Development of risk assess- ment methodology for surface disposal of municipal sludge. EPA 600/6-90/001. U.S.EPA. 1990. Development of risk assess- ment methodology for municipal sludge incin- eration. EPA 600/6-90/004. U.S. EPA. 1990. Interim methods for devel- opment of inhalation reference concentrations. EPA/600/8-90/066A. U.S. EPA. 1991. Preliminary risk assessment for parasites in municipal sewage sludge ap- plied to land. EPA600/6-91/001. U.S. EPA. Preliminary risk assessment for bacteria in municipal sewage sludge applied to land. EPA600/6-91/006. U.S. EPA. 1991. Preliminary risk assessment for viruses in municipal sewage sludge ap- plied to land. 10 ------- VANDERSLICE, P.P., J. ORME, E.V. O'HANIAN and C. SONICH-MULLIN. 1989. Problems in assessing the risks of mixtures of contaminants in drinking water. Tox. Ind.Hlth. 5(5): 747-756. VELAZQUEZ, S.F. VELAZQUEZ, S.F., C. SONICH-MULLIN and J.T. DU. Risk assess- ment of manganese: the essentiality of man- ganese. Proceedings of the 23rd Annual Conference on Trace Substances in Environ- mental Health. Held in the Hotel Westin in Cincinnati, OH, May 29-June 1989. ZAMUDA, C., C. DeROSA, H. HUIZENGA, B. JONES and J.LONGSTRETH. 1985. Devel- opment of chemical-specific parameters for the superfund risk assessment process. IQ: Proc. 6th National HMCRI Conf. on the Man- agement of Uncontrolled Hazardous Waste Sites. Held in Washington, DC., November 4- 6,1985. 11 ------- SELECTED PUBLICATIONS ON RISK ASSESSMENT (arranged by Category) CANCER RISK ASSESSMENT DOURSON, M.L. and J.M. BAXTER. 1981. Reduced incidence and growth rate of ure- thane induced lung adenomas in aging adult strain A mice. Toxicology. 20:161-178. DOURSON, M.L. and E.J. O'FLAHERTY. 1982. Relationship of lung adenoma preva- lence and growth rate to acute urethane dose and target cell number. J. Nat. Can. Inst. 69(4) :851-857. HILL, R.N., L.S. ERDREICH, O.E. PAYNTER, P.A. ROBERTS, S.L. ROSENTHAL and C.F. WILKINSON. Thyroid follicular cell carcinogenesis. Fund. Appl. Tox. 12: 629- 697. KOOYOOMIJIAN, J., C. DeROSA, and M. CHU. 1986. The use of potential cardnoge- nicity and chronic toxicity primary criteria for RA. la: Proc. 1986 Hazardous Waste Spills Conf., St. Louis, MO, May 5-8. MUKERJEE, D. and J.F. STARA. 1983. Rationale for developing criteria for carcino- gens. Proc. 76th Ann. Meeting - Air Pollution Control Association. Held in Atlanta, Georgia, June 19-24,1983. p. 1-8. MUKERJEE, D. and J.F. STARA. 1982. Rationale for quantitative risk assessment for carcinogens at uncontrolled hazardous waste sites. Proceedings of the XIII International Cancer Congress. Statistical Issues in Can- cer Etiology and Survival. Held in Seattle, Washington, September 8-15. p. 35. MUKERJEE, D. and O. Wassermann. 1990. Rationale for risk assessment of environmen- tal carcinogens. Proc. XIX Congreso Lationamericano de Quimica. O'FLAHERTY, E.J. and M.L. DOURSON. 1982. Relationship between urethane dose rate and adenoma latency: relevance of tumor growth rate and target cell number. J. Nat. Can. Inst. 69(4): 859-865. O'FLAHERTY, E.J. and M.L. DOURSON. 1983. A reply to the letter to the Editor" Cells of Origin of Lung Tumors in Mice". J. Nat. Can. Inst. 70(6): 991-992. STARA, J.F., D. MUKERJEE, R. McGAUGHY, P. DURKIN and M. DOURSON. 1983. The current use and studies on promot- ers and cocarcinogens in quantitative risk as- sessment. Env. Hlth. Persp. 50: 359-368. U.S. EPA. 1988. EPA approach for assessing the risks associated with chronic exposures to carcinogens. Integrated Risk Information Sys- tem (IRIS). Online. Intra-Agency Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH. February. NONCANCER RISK ASSESSMENT BARNES, D.G. and M.DOURSON. 1988. Reference dose (RfD): Description and use in health risk assessment. Reg. Tox. Pharm. 8: 471-486. BROWN, K.G. and L.S. ERDREICH. 1989. Statistical uncertainty in the no-observed-ad- verse-effect level. Fund. Appl. Tox. 13:235- 244. DeROSA, C.T., J. STARA and P. DURKIN. 1985. Ranking chemicals based on toxicity data. Tox. Ind. Hlth. 1:177-199. 12 ------- DOURSON.M.L. 1984. Toxicity-based meth- odology, thresholds and possible approaches, and uncertainty factors. Jn: Approaches to risk assessment for multiple chemical expo- sures. EPA600/9-84-008. p. 2-42. DOURSON, M.L. 1984. Health risk assess- ment for less-than-lifetime chemical exposure. In: Selected Approaches to Risk Assessment for Multiple Chemical Exposures: Progress Report on Guideline Development at ECAO- Cin., J.F. Stara and LS. Erdreich, Ed. U.S. EPA, Cincinnati, OH. EPA 600/9-84/014a. p. 9-15. DOURSON.M.L. 1986. New approaches in the derivation of the acceptable daily intake (ADI). Comments Toxicol. 1: 35-48. DOURSON.M.L. 1991. Overview of EPA's quantitative noncancer guidelines. Air and Waste Management Association. For Pre- sentation at the 84th Annual Meeting & Exhi- bition VAncouver, British Columbia, June 16- 21,1991. DOURSON, M.L. and C.T. DeROSA. 1991. The use of uncertainty factors in establishing safe levels of exposure. In: Statistics in Toxicology. Ed., D. Kreski and C. Franklin. Gordon and Breach Science Publishers, New York, NY. DOURSON, M.L., R. HERTZBERG, R. HARTUNG and K. BLACKBURN. 1985. Novel methods for the estimation of accept- able daily intake. Tox. Ind. Hlth. 1(4):23-33. DOURSON, M.L., R.C. HERTZBERG and J.F. STARA. 1986. Letters to the Editor. Fund. Appl. Tox. 6:182-184. DOURSON, M.L., L. KNAUF and J. SWARTOUT. 1991. On reference dose (RfD) and its underlying toxicity data base. Tox. Ind. Hlth. 8(3): 171-189. DOURSON, M.L and J. STAR A 1983. Regu- latory history and experimental support of un- certainty (safety) factors. Reg. Tox. Pharm. 3: 224-238. FARLAND, W. and M.L. DOURSON. 1992. Noncancer Health Endpoints: Approaches to quantitative risk assessment, (in press) FRADKIN, L., S. LUTKENHOFF, J. STARA, E. LOMNITZand B. CORNABY. 1985. Fea- sibility for performing and risk assessment on pathogens. J. Water Poll. Con. Fed. 57:1183- 1188. GUTH, D.J., A.M. JARABEK, L. WYMER, R.C. HERTZBERG. 1991. Evaluation of risk assessment methods for short-term inhalation exposure. Presentation at the 84th Annual Meeting of the Air & Waste Management As- sociation, June 16-21,1991, Vancouver, Brit- ish Columbia. HATTIS, D., L. ERDREICH and M. BALLEW. 1987. Human variability in susceptibility to toxic chemicals - a preliminary analysis of pharmacokinetic data from normal volunteers. Risk Analysis. 7(4): 415-424. HERTZBERG, R.C. 1984. Risk assessment for less-than-lifetime exposure, in: Selected Approaches to Risk Assessment for Multiple Chemical Exposures: Progress Report on Guideline Development at ECAO-Cin, J.F. Stara and LS. Erdreich, Ed., U.S. EPA, Cin- cinnati, OH. EPA 600/9-84-008. HERTZBERG, R.C. and T. CLARKSON. 1984. Interspecies conversion of dose and duration exposure - noncarcinogenictoxicants. in: Selected Approaches to Risk Assessment for Multiple Chemical Exposures: Progress Report on Guideline Development at ECAO- Cin, J.F. Stara and LS. Erdreich, Ed. U.S. EPA, Cincinnati, OH. EPA 600/9-84-014a. 13 Materials Belong Of PT Library ------- HERTZ BERG, R.C. 1989. Fitting a model to categorical response data with application to special extrapolation to toxicity. Health Phys- ics. 57(Suppl. 1): 404-409. HERTZBERG, R.C. and M. MILLER. 1985. A statistical model for species extrapolation us- ing categorical response data. Tox. Ind. Hlth. 1:43-57. HERTZBERG, R.C. and L. WYMER. 1991. Modeling the severity of toxic effects. Air & Management Association. In: Proceedings papers from the 84th Annual Meeting and Exhibition, June 16-21, 1991, British Colum- bia. Air and Waste Management Association. JARABEK, A.M., M.G. MENACHE, J.H. OVERTON, Jr., M.L. DOURSON, and F.J. MILLER. 1989. Inhalation Reference Dose (RfD): An application of interspecies dosim- etry modeling for risk assessment of insoluble particles. Health Physics. 57(Suppl. 1): 177- 183. JARABEK, A.M., M.G. MENACHE, J.H. OVERTON, Jr., M.L. DOURSON and F.J. MILLER. 1990. The U.S. Environmental Protection Agency's inhalation RfD methodol- ogy: Risk assessment for air toxics. Tox. Ind. Hlth. 6(5): 279-301. LU, F.C., and M.L. DOURSON. 1992. Safety risk assessment of chemicals: principles, pro- cedures and examples. J. Occ. Med. Tox. 1(4): 321-335. U.S. EPA. 1987. Human variability in suscep- tibility to toxic chemicals -!. Noncarcinogens. Office of Health and Environmental Assess- ment, Environmental Criteria and Assessment Office, U.S. EPA, Cincinnati, OH. Project Summary. EPA 600/S8-86-033. U.S. EPA 1988. Reference dose (RfD): De- scription assessments. Integrated Risk Infor- mation System (IRIS). Intra-Agency Refer- ence Dose (RfD) Work Group, Office of Health and Environmental Assessment, Environmen- tal Criteria and Assessment Office, Cincinnati, OH. February. U.S. EPA. 1989. Interim methods for devel- opment of inhalation references doses. EPA/ 600/8-88/006F. August. U.S. EPA. 1990. Interim methods for devel- opment of inhalation reference concentrations. EPA/600/8-90/066A. MIXTURES RISK ASSESSMENT BRUINS, R.J.B., L. FRADKIN and J. STARA. 1987. Summary of risk assessment method- ology for municipal sludge reuse or disposal options. Proc. National Conference on Mu- nicipal Sewage Treatment Plant Sludge Man- agement, Boston, MA, May27-29. Hazardous Material Control Research Inst., Silver Springs, MD. p. 21-24. CHANEY, R., R. BRUINS, D. BAKER, R. KORCAK, J. SMITH and D. COLE. 1987. Transfer of sludge-applied trace elements to the food chain. In: Land Application of Sludge, A.L. Page, T.J. Logan and J.A. Ryan, ed. Lewis Publishers, Inc., Chelsea, Ml. p. 67-99. CLEVENGER, M.A., R.M. PUTZRATH, S.L. BROWN, M.E. GINEVAN, C.T. DeROSA and M.M. MUMTAZ. 1991. Risk assessment of mixtures: A model based on mechanisms of action and interaction. IQ: Advances in Risk Anaylsis. Vol.8, Risk Analysis: Prospectsand Opportunity. C. Zeros, ed. Proceedings of the Annual Meeting of the Society for Risk Analy- sis. Held Oct. 30-Nov. 2,1988, Washington, DC. Plenum Press, New York. 14 ------- CLEVERLY, D., R. KELLAM, R. MORRISON, L. FRADKIN, R. BRUINS, P. McGINNIS and N. POSSIEL. 1987. Methodology for the assessment of health risks associated with multiple pathway exposure to municipal waste combustor emissions. Presented at the 80th Ann. Air Pollution Control Assoc. Conf., New York, June 21-26. CLEVERLY, D.H., C.C. TRAVIS and G.E. RICE. 1992. The analysis of indirect expo- sure to toxic air pollutants emitted from station- ary combustion sources: a case study. Pre- sented at the 85th Annual Meeting of the Air & Waste Management Association, June 21 -26, 1992, Kansas City, MO. CRUMPLER, E.P. and L. FRADKIN. 1987. Risk assessment in development of municipal sludge incineration regulations under 405(d) of the Clean Water Act. Proceedings National Conference on Municipal Sewage Treatment Plant Sludge Management, Boston, MA, May 27-29. Hazardous Material Control Research Inst., Silver Springs, MD. p. 30-35. DAWSON, G.W., C.J. ENGLISH and L. FRADKIN. 1988. The regulation of sludge disposal through application of risk assess- ment techniques. Presented at the U.S. EPA/ ASTM Symp. Chemical and Biological Char- acterization of Municipal Sludges,Sediments,Dredge Spoils and Drill- ing Muds, Cincinnati, OH, May 20-22. DeROSA, C.T., H. CHOUDHURY and W.B. PEIRANO. 1991. An integrated expsoure and pharmacokinetic based approach to the assessment of complex exposures lead: a case study. Tox. Ind. Hlth. 7(4): 321-248. DeROSA, C.T., M.L. DOURSON and R. OSBORNE. 1989. Risk assessment initiative for noncancer endpoints: Implications for risk characterizations of chemical mixtures. Tox. Ind. Hlth. 5(5): 805-824. ERDREICH, L.S. and C. SONICH-MULLIN. 1984. Hypersusceptible subgroups of the population in multiple chemical risk assess- ment. In: Approaches to Risk Assessment of Multiple Chemical Exposures, J.F. Stara and LS. Erdreich, Ed., U.S. EPA, Cincinnati, OH. EPA 600/9-84-008. ERDREICH, L.S. and C. SONICH-MULLIN. 1984. Health assessment of exposures to chemical mixtures: Subpopulations at Greater Risk. In: Approaches to Risk Assessment for Multiple Chemical Exposures. EPA 600/9-84- 008. FRADKIN, L, R. BRUINS, S. LUTKENHOFF, J. STARA, E. LOMNITZand A. RUBIN. 1987. Screening methodology for assessing poten- tial health effects from municipal sludge incin- erators. J. Air Poll. Con. Assoc. 37:395-399. FRADKIN, L, R. BRUINS, B. PEIRANO, S.LUTKENHOFF, J. STARA, G. DAWSON and J. ENGLISH. 1986. Risk assessment methodology for determining groundwater contamination from landfilling sludge, in: Proc. American Society of Civil Engineers s(ASCE) Environmental Engineering Conf., Cincinnati, OH, July 8-10,1986. FRADKIN, L, C. GERBA, S. GOYAL, P. SCARPING, R.BRUINSandJ.STARA. 1989. Potential public health concerns from patho- gens in municipal wastewater sludge. J. Env. Hlth. 51 (3): 148-152. FRADKIN, L., T. HARTLAGE, R. HARLESS, J. WALLINGS and D. CLEVERLY. 1988. Multimedia, multipollutant field study to estab- lish levels of toxic contaminants in air, soil, sediment, waterand agricultural products from a model municipal waste combustor. Pre- sented at the 1988 EPA/APCA Symposium on Measurement of Toxic and Related Air Pollut- ants, Raleigh, NC. May 1-4,1988. 15 ------- FRADKIN, L, N. KOWAL and P. SCARPING. 1987. Multi-media microbiological risk as- sessment methodology for municipal waste- water sludges. Proc. National Conference on Municipal Sewage Treatment Plant Sludge Management. Boston, MA, May 27-29. Haz- ardous Material Control Research Inst., Silver Springs, MD. p.25-29. HERTZBERG, R.C. 1992. Studies on toxicity of mixtures and interacting chemicals user's guide. (MIXTOX) U.S. EPA, Environmental Criteria and Assessment Office, Cincinnati, OH. 45268. Available on diskette. HERTZBERG, R.C. and P. DURKIN. 1984. Multiple chemical assessment. In: Selected Approaches to Risk Assessment for Multiple Chemical Exposures: Progress Report on Guideline Development ECAO-Cin, J.F. Stara and LS. Erdreich, Ed. U.S. EPA, Cincinnati, OH. EPA 600/9-84/014a. HERTZBERG, R.C. and J. PATTERSON. 1987. Approaches to the quantitative estima- tion of health risk from exposure to chemical mixtures. Proceedings of the Twenty-fourth Hanford Life Sciences Symposium on Health and Environmental Research on Complex Organic Mixtures. Oct. 20-24,1985, Richland, Washington. LOMNITZ, E., R. BRUINS and L. FRADKIN. 1985. Screening chemicals in municipal slud- ges. Biocycle 26: 52-54. LUTKENHOFF, S., R. HERTZBERG, C. SONICH-MULLIN. 1988. Applicability of U.S. EPA risk assessment guidelines for chemical mixtures. In: Trace Substances in Environ- mental Health-XXII, Proc. University of Missouri's 22nd Ann. Conf.TRace Substances in Environmental Health, St. Louis, Missouri, May 23-26. MUMTAZ, M.M. and R.C. HERTZBERG. 1992. The status of interactions data in risk of chemical mixtures. In: Hazard Assessment Chemicals, Vol. 8. J. Sexena, ed. Hemi- sphere Publishing Co., Washington, D.C. (in press) MUMTAZ, M.M., D.L. McKEAN, R.J. BRU- INS, R.S. SCHOENY and C.T. DeROSA 1991. Research strategy for risk characteriza- tion of complex exposures. Proceedings of the Fourth International Conference on the Combined Effects of Environmental Factors. Held in Baltimore, Maryland Sept. 30,1990 - Oct.3, 1990. Published by Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland. SCHOENY, R.S. 1990. U.S. Environmental Protection Agency processes for consensus building for hazard identification, in: Pesticide Residues and Food Safety - A Harvest of Viewpoints. B.G. Tweedym H.J. Dishburger, L.G. Ballantine and J. McCarthy. 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Held in Cleveland, Ohio, July 10-15, 1989. Prog. Clin. Biol. Res. 340D: 1- 387,1990. STARA,J.F. 1989. First generation of an new science: risk assessment in transition. Tox. Ind. Hlth. 5(5): 621-627. STAR A, J., M. DOURSON and D. DeROSA. 1980. Water Quality Criteria: applications, in: Conference Proceedings on Environmental Risk Assessment: How New Regulations will Affect the Utility Industry. Held in New Or- leans, Louisiana, Dec. 10-11,1980. Prepared forthe Electric Power Research Institute, Palo Alto, CA. STARA, J.F., J. PATTERSON and M.L. DOURSON. 1986. Risk assessment ap- proaches for ground water contamination by pesticides and other organic substances. ACS Symposium organic substances. ACS Sym- posium Series: Evaluation of Pesticides in Ground Water. W.Y. Garner, R.C. Honecycutt, H.N. Nigg, ed. American Chemical Society, Washington, DC. U.S. EPA. 1980. Appendix C. 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Development of risk assess- ment methodology for municipal sludge landfilling. EPA600/6-90/008. 21 ------- U.S. EPA. 1989. Pathogen risk assessment for land application of municipal sludge, Vol. 1: Methodology and computer model. EPA 6007 6-90/002A. U.S. EPA. 1989. Pathogen risk assessment for land application of municipal sludge, Vol. 2: User's manual. EPA 600/6-90/002B. U.S. EPA. 1990. Development of risk assess- ment methodology for surface disposal of municipal sludge. EPA 600/6-90/001. U.S. EPA 1990. Development of risk assess- ment methodology for municipal sludge incin- eration. EPA 600/6-90/004. U.S. EPA. 1991. Preliminary risk assessment for parasites in municipal sewage sludge ap- plied to land. EPA600/6-91/001. U.S. EPA. Preliminary risk assessment for bacteria in municipal sewage sludge applied to land. EPA600/6-91/006. U.S. EPA. 1991. Preliminary risk assessment for viruses in municipal sewage sludge ap- plied to land. 22 ------- SYMPOSIA Conference on Environmental Risk Assessment: How New Regulations Will Affect the Utility Industry New Orleans, Louisiana, December 10-11,1990 Approaches to Risk Assessment for Multiple Chemical Exposures Cincinnati, Ohio, September 29-30,1982 XII International Cancer Congress, Statistical Issues in Cancer Etiology and Survival Seattle, Washington, September 8-15,1983. The 76th Annual Meeting - Air Pollution Control Association Atlanta, Georgia, June 19-24,1983 The 19th Annual Conference on Trace Substances in Environmental Health Columbia, Missouri, June 3-6,1985 Advance in Health Risk Assessment for Systemic Toxicants andchemical Mixtures Cincinnati, Ohio, October23-25,1985 The 6th National HMCRI Conference on the Management of Uncontrolled Hazardous Waste Sites Washington, DC, November 4-6,1985 The 24th Hanford Life Sciences Symposium on Health and Environmental Research on Complex Organic Mixtures Richland, Washington, October 20-24,1985 The 5th International Symposium on Chlorinated Dioxins and Related Compounds Bayreuth, W. Germany, September 16-19,1986 The 1986 Hazardous Waste Spills Conference St. Louis, Missouri, May 5-8, 1986 Seventy-seventh Annual Meeting of the American Association for Cancer Research Los Angeles, Califormia, May 7-10,1986 The American Society of Civil Engineers Environmental Engineering Conference Cincinnati, Ohio, July, 8-10,1986 The 6th Annual Conference on Water Chlorination: Environmental and Health Effects Oak Ridge, Tennessee, May 3-8,1987 23 ------- National Conference on Municipal Sewage Treatment Plant Sludge Management Boston, Massachusetts, May 27-29,1987 The 80th Annual Air Pollution Control Association Conference New York, New York, June 21 -26,1987 The U.S. EPA/ASTM Symposium on Chemical and Biological Characterization of Municipal Sludges, Sediments, Dredge Spoils and Drilling Muds Cincinnati, Ohio, May 20-22,1988 The 22nd Annual Conference Trace Substancesin Environmental Health University of Missouri, St. Louis, Missouri, May 23-26,1988 The Annual Meeting of the Society for Risk Analysis Washington, DC, Oct. 30-Nov. 2,1988 Water Quality Technology Conference, American Water Works Association Philadelphia, Pennsylvania, November 12-16,1989 The 5th International Symposium on Chlorinated Dioxins and Related Compounds Las Vegas, Nevada, October 4-9,1989 The 5th International Conference on Environmental Mutagens Cleveland, Ohio, July 10-15,1989 The 23rd Annual Conference on Trace Substances in Environmental Health Hotel Westin, Cincinnati, Ohio, May 29-June1,1989 The 24th Annual Conference on Trace Substances in Environmental Health Hotel Westin, Cincinnnati, Ohio, July 8-12,1990 The NATA ARW "Nitrate Contamination: Exposure, Consequence and Control" University of Nebrask - Lincoln, September 10-14,1990 The 1991 Annual Meeting of the Society of Toxicology Loews Anatole Hotel, Dalla, Texas, February 25 - March 1,1991 The 75th Annual Meeting of the Federation of American Societies for Experimental Biology Atlanta, Georgia, April 21-25,1991 The 1991 National Solid WAste Forum on Integrated Municipal Waste Management Las Vegas, Nevada, July 15-17,1991 The 84th Annual Meeting of the Air and Waste Management Association Vancouver, British Columbia, June 16-21,1991 The 85th Annual Meeting of the Air and Waste Management Association Kansas City, Missouri, June 21-26,1992 ------- |