EPA-450/3-77-008b
October 1976
      PRELIMINARY SCORING
      OF SELECTED ORGANIC
             AIR POLLUTANTS
                 APPENDIX I -
  CHEMISTRY, PRODUCTION,
               AND TOXICITY
               OF CHEMICALS
                A THROUGH C
  U.S. ENVIRONMENTAL PROTECTION AGENCY
      Office of Air and Waste Management
   Office of Air Quality Planning and Standards
   Research Triangle Park, North Carolina 27711

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                                   EPA-450/3-77-008b
           PRELIMINARY SCORING


OF SELECTED ORGANIC AIR POLLUTANTS


                  APPENDIX I -


         CHEMISTRY, PRODUCTION,


                 ANDTOXICITY


                 OF CHEMICALS


                 A THROUGHC


                         by

                  J. Dorigan, B. Fuller and R. Duffy

                     The Mitre Corporation
                      Metrek Division
                     Westgate Research Park
                	McLean, Virginia 22101	
                     Contract No. 68-02-1495
                      Project No. 077L





                 EPA Project Officer: David R. Patrick






                       Prepared for



               ENVIRONMENTAL PROTECTION AGENCY

                 Office of Air and Waste Management

               Office of Air Quality Planning and Standards

               Research Triangle Park, North Carolina 27711



                       October 1976

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                           PREFACE

     A program is being developed by the Emission Standards and
Engineering Division of the U.S.  Environmental  Protection Agency to
determine the extent and environmental  effects  of atmospheric industrial
emissions of synthetic organic chemicals.  As part of the initial effort,
EPA requested that the MITRE Corporation, METREK Division, devise a
system for identifying those chemicals that may be released to the
atmosphere from chemical manufacturing plants and whose health effects
have been documented.  To address this need, three general categories of
information for each compound to be evaluated were deemed directly
relevant:
     (1) the quantity of the compound produced;
     (2) the potential for atmospheric release from chemical manu-
         facturing plants, and
     (3) the toxicological effects of the compounds.
The results of this study are presented in the accompanying report
"Preliminary Scoring of Organic Air Pollutants."
     The following dossiers were prepared for each of the 637 compounds
under consideration in an attempt to collate the pertinent data for
subsequent evaluation.

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                       TABLE OF CONTENTS
Acenaphthene
Acetal
Acetaldehyde
Acetaldol
Acetamide
Acetamidpfluorene
Acetanilide
Acetic -a,cid
Acetic  anhydride
Acetone
Acetone cyanohydrin
Acetonitrile
Acetophenone
Acetylene
Acetylene tetrabromide
Acetylene tetrachloride
Acrolein
Acrylamide
 Acrylic acid
 Acrylonitrile
 Adipic acid
 Alachlor
 Aldrin
 Allyl  alcohol
 Allyl  chloride
 Allylene
 Allyl  naphthalene
 Amiben
 p-Aminobenzoic .acid
 p-Aminobiphenyl
 Aminoethylethanolamine
 Amyl acetate
 Amyl alcohol
 Amylamines
  Amyl chloride (s)
  Amylene
  Amyl ether
  Amyl mercaptan
  Aniline
  Aniline hydrochloride
  Anisidine  (o and  p)
  Anisole
  Anthranilic acid
  Anthraquinone
  Auramine
  Azodrin
                                  ill

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                 TABLE OF CONTENTS  (CONTINUED)
Banvel D                                                     AI-94
Banvel T                                                     AI-96
Benzaldehyde                                                 AI-98
Benzamide                                                    AI-100
Benzene                                                      AI-102
Benzenedisulfonic acid                                       AI-104
Benezenesulfonic acid                                        AI-106
Benzidine                                                    AI-108
Benzil                                                       AI-110
Benzilic acid                                                AI-112
Benzoic acid                                                 AI-114
Benzoin                                                      AI-116
Benzonitrile                                                 AI-118
Benzophenone                                                 AI-120
Benzoquinone                                                 AI-122
Benzotrichloride                          .                   AI-124
Benzoyl chloride                                             AI-126
Benzyl alcohol                                               AI-128
Benzylamine                                                  AI-130
Benzylbenzene                                                AI-132
Benzyl benzoate                                              AI-134
Benzyl chloride                                              AI-136
Benzyl dichloride                                            AI-138
Bis(chloromethyl) ether                                      AI-140
Bisphenol A                                                  AI-142
Bromacil                                                     AI-144
Bromobenzene                                                 AI-146
Bromonaphthalene                                             AI-148
1,3-Butadiene                                                AI-150
Butane                                                       AI-152
1-Butene                                                     AI-154
2-Butene (cis+trans)                                         AI-156
2-Butoxyethanol                                              AI-158
n-Butyl acetate                                              AI-160
sec-Butyl acetate                                            AI-162
tert-Butyl acetate                                           AI-164
n-Butylacrylate                                              AI-166
n-Butyl alcohol                                              AI-168
sec-Butyl alcohol                                            AI-170
tert-Butyl alcohol                                           AI-172
n-Butylaldehyde                                              AI-174
sec-Butylamine                                               AI-176
tert-Butylamine                                              AI-178.
Butylbenzoic acid                                            AI-180
Butylene                                                     AI-182
1,3-Butylene g'lycol                                          AI-184

                                TV

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                 TABLE OF CONTENTS (CONTINUED)
n-Butyl glycidyl ether
Bu ty liner cap t an
tert-Butylphenol
tert-Butyl'j toluene
n-Butyric acid
n-Butyric anhydride
Butyronitrile
Buxten
Cacodylic acid
Calcium propionate
Calcium stearate
Camphor
Caprolactam
Captan
Carbaryl
Carbofuran
Carbon disulfide
Carbon tetrabromide
Carbon tetrachloride
Castor oil
Cellulose acetate
Chloranil
Chlordane
Chloroacetaldehyde
Chloroacetic acid
Chloroacetophenone
m-Chloroaniline
o-Chloroaniline
p-Chloroaniline
o-Chlorobenzaldehyde
p-Chlorobenzaldehyde
Chlorobenzene
Chlorobenzilate
Chlorobenzoic acid
o-Chlorobenzoyl chloride
b-Chlorobenzylidene malonitrile
Chlorodifluoroethane
Chlorodifluoromethane
2-Chloro-4-ethylamino-6-isopropylamino-s-triazine
Chloroform
Chloronaphthalene
m-Chloronitrobenzene
o-Chloronitrobenzene
p-Chloronitrobenzene
1-Chloro-l-nitropropane
m-Chlorophenol
AI-186
AI-188
AI-190
AI-192.
AI-194
AI-196
AI-198
AI-200
AI-202
AI-204
AI-206
AI-208
AI-210
AI-212
AI-214
AI-216
AI-218
AI-220
AI-222
AI-224
AI-226
AI-228
AI-230
AI-232,
AI-234
AI-236
AI-238
AI-240
AI-242
AI-244
AI-246
AI-248
AI-250
AI-252
AI-254
AI-256
AI-258
AI-260
AI-262
AI-264
AI-266
 AI-268
AI-270
AI-272
 AI-274
 AI-276

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                   TABLE OF CONTENTS (CONCLUDED)
o-Chlorophenol                                                AI-278
p-Chlorophenol                                                AI-280
Chloroprene                                                   AI-282
Chloropropham                                                 AI-284
m-Chlorotoluene                                               AI-286
o-Chlorotoluene                                               AI-288
p-Chlorotoluene                                               AI-290
Citric acid                                                   AI-292
Crag herbicide 1                                              AI-294
m-Cresol                                                      AI-296
o-Cresol                                                      AI-298
p-Cresol                                                      AI-300
Crotonaldehyde                                                AI-302
Crotonic acid                                                 AI-304
Cumene                                                        AI-306
Cumene hydroperoxide                                          AI-308
Cyanoacetic acid                                              AI-310
Cyanogen chloride                                             AI-312
Cyanuric acid                                                 AI-314
Cyanuric chloride                                             AI-316
Cyclohexane                                                   AI-318
Cyclohexanol                                                  AI-320
Cyclohexanone                                                 AI-322
Cyclohexene                                                   AI-324
Cyclohexylamine                                               AI-326
Cyclopentadiene                                               AI-328
Cyprex                                                        AI-330
                                 vi

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                  APPENDIX I







CHEMISTRY, PRODUCTION AND TOXICITY OF SELECTED




         SYNTHETIC ORGANIC CHEMICALS
                     AI-1

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Acenapthene
                                      CHEMICAL  NAME
    CAS Number:  208-96-8
    Chemical Name:    Acenaphthlylene*
    Synonyms:  i ,2-Dihydro^acenaphthylene
               1,8-Ethylene naphthalene
               Naphthyleneethylene
    Molecular	
      Formula:  CJ2H8
    Structure:
    Chemical Properties

       Molecular Weight:  154.21

       Vapor Pressure: 10 mm at 131.2°C

       Boiling Point:   277.5°C

       Density:  1.0242 at 99°C/4°C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-slight
Physical State:  Solid

Vapor Density:  5.32

Melting Point:  96.2°C

Solubility:  Insoluble (H2O)
                                              AI-2

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                                                                         Acenapthene


                              PRODUCTION DATA
Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
Non-lethal Acute Effects:
     Irritant to skin and mucous membranes
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:    Neoplastic effects


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                        AI-3

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Acetal
                                      CHEMICAL NAME
    CAS Number:   105-57-7
    Chemical Name: Diethyl acetal acetaldehyde

    Synonyms:  1,1-Diethoxy ethane
                Ethylidene diethyl ether
                Diethylacetal
    Molecular   	
      Formula:
    Structure:  CH3 CH
                           0-C2H5
                           0-C2H5
    Chemical Properties

       Molecular Weight:   118.18

       Vapor Pressure:  28.8 at 25°C
       Boiling Point:   103.2°C at 760 mm

       Density:  0.8314 at 20°C/4iC

       Octanol/Water Parti-
         tion Coefficient:  1.17

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:  Liquid

Vapor Density: 4.08 mp at 100°C

Melting Point:

Solubility:  Soluble (H2O)
     Safety Hazard:  Fire-dangerous
                   Explosion-moderate
                                              AI-4

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                                                                                   Acetal
                               PRODUCTION DATA
Annual U.S.   	
 Production:  56.8 x 106 Ibs. (1975)

Fraction of
 Dispersion:   1.0

Release Rate (million Ibs/yr): 63.3
                      Consumption:  60.4 x 106 Ibs.

                      Fraction of Pro-
                        duction Lost:  0.03
Acute Toxicity
     LD50
     LCLo

Non-lethal Acute Effects:
     Narcotic
                                 TOXICITY DATA
4570 mg/kg
4000 ppm (4 houis)
 Animal
rat
rat
  Route
oral
inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
                                        AI-5

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Acetaldehyde
                                     CHEMICAL  NAME
    CAS Number:   75-07-0

    Chemical Name:    Acetaldehyde

    Synonyms:  Acetic aldehyde
               Ethyl aldehyde

    Molecular	
      Formula:   C2H4O
    Structure:    CH3 - C
O

H
    Chemical Properties

       Molecular Weight:  44.05

       Vapor Pressure: 923 Tons at 25°C
       Boiling Point:    20.8°C at 760 mm

       Density:  0.7834 at 18°C/4°C

       Octanol/Water Parti-
         tion Coefficient:  0.43

     Environmental Persistence

       BOD:    126 at 20°C for 5 days

       Atmospheric Reactivity:
     Safety Hazard:   Fire-dangerous-oxidizes
                   Explosion-severe
                         Physical State:  Liquid

                         Vapor Density:  1.52

                         Melting Point:  -121°C
                         Solubility:  Infinite (hot H2O)
                                             AI-6

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                                                                         Acetaldehyde
                               PRODUCTION DATA
Annual U.S.	
 Production:   1500 x 10* Ibs. '(1976)
Fraction of
  Dispersion:
0.01
Consumption:   1300 x 106 Ibs. (1976)

Fraction of Pro-
 duction Lost:  0.015
Release Rate (million Ibs/yr):  36.2
                                 TOXICITY DATA
Acute Toxicity
     LDSO
      LDLo
      LCLo

Non-lethal Acute Effects:
      TCLo
             Dosage
           1930 mg/kg
            640 mg/kg
           1232 mg/kg
            560 mg/kg
            500 mg/kg
           4000 ppm (4 hours)
            134 ppm
Chronic Toxicity

   U.S. Occupational Standard:  TWA-200 ppm
   Carcinogenicity:
      TDLo

   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
        Eye irritation
             50 ppm
 Animal
rat
lat
mouse
mouse
tat
rat
human
             60 mg/kg (79 weeks)    rat
                                 TLV: 200 ppm
  Route
oral
subcutaneous
oral
subcutaneous
intraperitoneal
inhalation
inhalation
                   subcutaneous
                                        AI-7

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Acetaldol
                                     CHEMICAL  NAME
    CAS Number:
   107-89-1
    Chemical Name:   3-Hydroxybutyraldehyde

    Synonyms:    Acetaldol
                 Aldol
    Molecular
      Formula:
3-Butanolal

C4H802
                       OH
                                       H
    Structure:   CH3 - CH - CH2  - C
                                     \\
                                       O
     Chemical Properties

       Molecular Weight:    88.12

       Vapor Pressure:   10 mm at 25°C

       Boiling Point:  83°C at 20 nun
                    Decomposes at 85°C
       Density:   1.103 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:
            Fire-moderate
                                    Oxybutyric aldehyde
                                   Physical State:   Liquid

                                   Vapor Density:   3.04

                                   Melting Point:

                                   Solubility:    Infinite (H2O)
                                              AI-8

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                                                                            Acetaldol
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITYDATA

Acute Toxicity              Dosage               Animal               Route
       LDSO              2,180 mg/kg           rat                 oral
                           140mg/kg           rat                 skin
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Not tested


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-9

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Acetamide
                                     CHEMICAL NAME
    CAS Number:     60-35-5

    Chemical Name:   Acetamide

    Synonyms:    Acetic acid amide
                 Ethanamide

    Molecular
      Formula:    C2HSNO
                       O
    Structure:    CH3 - C -  NH2
    Chemical Properties

       Molecular Weight:   59.07

       Vapor Pressure:   1 mm at 65°C

       Boiling Point:     221.2°C at 760mm

       Density:   1.1590 at 20° C/4°C

       Octanol/Water Parti-
         tion Coefficient:   -1.46

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
           Disaster hazard-dangerous-cyanide
Physical State:   Solid

Vapor Density:

Melting Point:    82.3°C

Solubility:    Soluble (H2O)
                                              AI-10

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                                                                          Acetamide
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duetion Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
       LD50                10gm/kg            rat                 subcutaneous
                         8300 mg/kg            mouse              subcutaneous

 Non-lethal Acute Effects:
       Mild irritant
Chronic Toxicrty

   U.S. Occupational Standard:



   Carcinogenicity:
       TDLo              456 gm/kg (52 weeks)    rat                 oral

   Mutagenicity:

   Teratogenicity:                               f LV:

   Other Chronic Effects:
                                       AI-11

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Acetamidofluorene
                                    CHEMICAL  NAME
    CAS Number:   53-96-3

    Chemical Name:    N-fluoren-2-yl-acetamide

    Synonyms:  2-Acetamidofluorene
               N-(2-fluorenyl)acetamide
               2-Acetylaminofluoiene
    Molecular
     Formula:  C15Hi3NO
    Structure:
    Chemical Properties

       Molecular Weight:  223.28

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:    Solid

Vapor Density:

Melting Point:   194°C

Solubility:   Insoluble (H2O)
    Safety Hazard:
                                            AI-12

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                                                                Acetamidofluorene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                        Consumption:

                        Fraction of Pro-
                         duction Lost:
                                 TOXICITY DATA
Acute Toxicity
    Dosage
     1020 mg/kg
 Animal
mouse
   Route
oral
Chronic Toxicity

   U.S. Occupational Standard:  (aii) Carcinogen
   Carcinogenicity:
     TDLo
  15gm/kg(4weeks)
 475 mg/kg (11 weeks)
 260 mg/kg (1 week)
 192 mg/kg (8 weeks)
 560 mg/kg (14 days)
4400 mg/kg (65 weeks)
7980 mg/kg (38 weeks)
   Mutagenicity:

   Teratogenicity:
     TDL6
   Other Chronic Effects:
    100 mg/kg
hamster
rat
rat
rat
mouse
rabbit
hamster
 TLV:
mouse
intravenous
oral
skin
intraperitoneal
oral
oral
oral
                   parenteral
                                        AI-13

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Acetanilide
                                      CHEMICAL  NAME
    CAS Number:   103-84-4

    Chemical Name:   Acetanilide
    Synonyms:   N-phenylacetamide
                Antiflbrin

    Molecular
      Formula:   CgH9NQ.
    Structure:   CH3 - C
                           O
     Chemical Properties

       Molecular Weight:  135.17

       Vapor Pressure:  lmmatll4°C
       Boiling Point:    303.8°C at 760 mm

       Density:  1.2190at 15°C/4°C

       Octanol/Water Parti-
         tion Coefficient:  1.59

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Physical State:  Solid

Vapor Density:  4.65

Melting Point:  114.3°C

Solubility:  Slightly soluble (H2O)
     Safety Hazard:  Fire-slight
                                               AI-14

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                                                                            Acetanilide
                               PRODUCTION DATA

Annual U.S.
 Production:   5.5 x 106 Ibs. (1967)                Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:    0.01                               duction Lost: 0.015

Release Rate (million Ibs/yr):
                                 TOXICITYDATA

Acute Toxicity               Dosage               Animal               Route

     LDSO               800mg/kg            rat                 oral
                        1210 mg/kg            mouse              oial
     LDLo              1000 mg/kg            mouse              intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-15

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Acetic Acid
                                      CHEMICAL NAME
    CAS Number:  64-19-7

    Chemical Name:   Acetic acid

    Synonyms: Methane carboxylic acid
               Ethylic acid
               Glacial acetic acid
    Molecular  	
      Formula: C2H4O2
    Structure:  CH3 C
                         o
                         OH
     Chemical Properties

       Molecular Weight:  60.05

       Vapor Pressure: 11.4 mm at 20°C
       Boiling Point:   117.9°C at 760mm

       Density:  1.0492 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:  -0.31

     Environmental Persistence

       BOD:    102.7 at 20°C for 20 days

       Atmospheric Reactivity:
     Safety Hazard:  Fire-moderate
                   Explosion-moderate
           Ethanoic acid
           Vinegar acid
Physical State:  Liquid

Vapor Density: 2.07

Melting Point:  16.6°C

Solubility:  Infinite (H20)
                                              AI-16

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                                                                              Actftic AcM
                                PRODUCTION DATA
Annual U.S.
 Production:   2097.0 x 106 Ibs. (1975)

Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr):  55.9
                      Consumption:  2097.6 x 106 Ibs.

                      Fraction of Pro-
                        duction Lost: 0.015
Acute Toxicity
      LDSO
      LDLo
Non-lethal  Acute  Effects:
      Iiritant-LDL0

      Gastrointestinal
         tract-LDLo
                                  TOXICITY DATA
  Dosage
3310mg/kg
4960 mg/kg
 525 mg/kg
1200 mg/kg
1200 mg/kg
 600 mg/kg
                          5620 ppm (1 hour)
 816 ppm (3 months)
  50 ppm

1470 mg/kg
 Animal
rat
mouse
mouse
rabbit
rabbit
rabbit
mouse
human
human

human
  Route
oral
oral
intravenous
oral
subcutaneous
rectal
inhalation
inhalation
inhalation

oral
Chronic Toxicity

   U.S. Occupational Standard:  TWA-10 ppm



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Dermatitis
Ulcers
                      TLV: 10 ppm
                          Slight irritation of   _^	
                            respiratory tract  100-260 ppm (1 hour)
                          Conjuctivitis      	
                          Bronchitis, pharyngitis
                          Erosion of exposed teeth
                                         AI-17

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Acetic  anhydride
                                     CHEMICAL  NAME
    CAS Number:   108-24-7

    Chemical Name:    Acetic anhydride

    Synonyms:  Acetyl oxide
               Acetic oxide
               Ethanoic anhydride
    Molecular	
      Formula:  €41)603
    Structure:      3
                        O
                        O
               CH3 C = O
    Chemical Properties

       Molecular Weight:  102.09

       Vapor Pressure: 5.09 mm at 25°C

       Boiling Point:  139.55°C

       Density:  1.082 at 200C/4°C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-moderate
                  Explosion—moderate
Physical State:  Liquid

Vapor Density:  3.50

Melting Point:  -73.1°C

Solubility:   Very soluble (H2O)
                                             AI-18

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                                                                     Acetic anhydride
                               PRODUCTION DATA

Annual U.S.
 Production:   1633.1 x 106 Ibs. (1974)             Consumption:  1637 x 106 Ibs.

Fraction of                                     Fraction of Pro-
 Dispersion:    0.01                               duction Lost: 0.01S

Release Rate (million Ibs/yr):  39.4
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
     LDSO               1780mg/kg            rat                 oral
                         1000 ppm (4 hours)      rat                 inhalation
Non-lethal Acute Effects:
     Irritant to eyes and upper respiratory tract
     Ingestion-burning pain in stomach followed by nausea and vomiting
Chronic Toxicity

   U.S. Occupational Standard:  TWA: 5 ppm (air)



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV: 5 ppm

   Other Chronic Effects:
                                     '-.  AI-19

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Acetone
                                      CHEMICAL  NAME
    CAS Number:   67-64-1

    Chemical Name:   Acetone
    Synonyms:  2-Propanone
               , Dimethyl keton¥\
                (3-Ketone propane
    Molecular
      Formula:  CsH6O
Methylketone
Pyroacetic ether
                CH
    Structure:         C = O
                CH,
     Chemical Properties

        Molecular Weight:   58.08

        Vapor Pressure:  400 mm at 39.5°C
       Boiling Point:   56.2°C at 760 mm

       Density:  0.7972 at 15°C/4°C

       Octanol/Water Parti-
         tion Coefficient:   0.55

     Environmental Persistence

       BOD:    1.84 for 20 days at 20°C
         Physical State:  Liquid

         Vapor Density:  2.0

         Melting Point:   -95.35°C

         Solubility:   Infinite (H2O)
                72% of theoretical for 10 days at 20°C
       Atmospheric Reactivity:  Oxygen uptake: 50 mg/1 during 12 hours
     Safety Hazard:  Fire-dangerous
                   Explosion-moderate
                                              AI-20

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                                                                                    Acetone
                                PRODUCTION DATA
Annual U.S.
 Production:    1980.3 x 106 Ibs. (1974)

Fraction of
 Dispersion:    0.31

Release Rate (million Ibs/yr):  533.9
                       Consumption:   1946.0 x 106 Ibs.

                       Fraction of Pro-
                        duction Lost:  0.0IS
                                  TOXICITY DATA
Acute Toxicity
      LDSO

      LDLo

Non-lethal Acute Effects:
  Dosage
1295 mg/kg
5300 mg/kg
8000 mg/kg
      Eye effects-TCLo      500 ppm
      Central nervous system
                  ~~TCj~o 12,000 ppm (4 hours)
 Animal
mouse
rabbit
dog
                       human
  Route
intraperitoneal
oral
oral
                                           air exposure
      Paralysis
Chronic Toxicity

   U.S. Occupational Standard:   TWA: 1000 ppm



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Skin irritation
TLV:  1000 ppm

Odor perception:   1.6 ppm
                          Chronic respiratory
                             tract irritation,
                             dizziness
                          Minor irritation of
                             eyes and nose
                    1000 ppm (3 hours/day)
                    3000 ppm

-------
Acetone cyanohydrin
                                     CHEMICAL NAME
    CAS Number:   7S-86-S

    Chemical Name: 2-Methyl lactonitrile
    Synonyms:   HydioxyisobutyronitrOe
    Molecular   	
      Formula:   C4H7NO
                      OH
                       I
    Structure:   CH3 - C  - CN
                       I
                      CH,
     Chemical Properties

       Molecular Weight:  85.11

       Vapor Pressure:
       Boiling Point:   82°C at 23 mm

       Density:  0.932 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:  Fire-slight
Physical State:  Liquid

Vapor Density:  2.93

Melting Point:   -20°C

Solubility:   Very soluble, decomposes in H2O
                                              AI-22

-------
                                                               Acetone cyanohydrin
                              PRODUCTION DATA
Annual U.S.
 Production:   537.9 x 106 Ibs (1969)

Fraction of
 Dispersion:   0.01

Release Rate (million Ibs/yr): 6.0
                     Consumption:  100 x 10s Ibs (1975)

                     Fraction of Pro-
                       duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
     LDSO
      LCSO
      LCLo
  Dosage
 17 mg/kg
  3mg/kg
 14 mg/kg
 17 mg/kg
  9 mg/kg
575 ppm (2 hours)
 63 ppm (4 hours)
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
mouse
rabbit
rabbit
guinea pig
mouse
rat
  Route
oral
oral
oral
skin
oral
inhalation
inhalation
                      TLV: Unconfirmed
                                        AI-23

-------
Acetonftrile
                                      CHEMICAL NAME
    CAS Number:   75-05-8

    Chemical Name:   AcetonitrUe

    Synonyms:  Methyl cyanide
                Cyanomethane
                Ethanenitrile
    Molecular   	
      Formula:  C2H3N
Ethyl nitrile
Methane carbonitrile
    Structure:   CH3 - C = N
     Chemical Properties

        Molecular Weight:   41.05

        Vapor Pressure:  92.8 mm at 25°C

        Boiling Point:   81.6°C

        Density:  0.786 at 20°C/20°C

        Qctanol/Water Parti-
         tion Coefficient:   -0.34
         Physical State:  Liquid

         Vapor Density: 1.42

         Melting Point:  -45.72°C

         Solubility:  Infinite (H2O)
     Environmental Persistence

        BOD:    Total theoretical oxygen demand 3.32

        Atmospheric Reactivity:   Reacts to oxidizing materials
     Safety Hazard:  Fiie-dangerous
                   Disaster hazard-dangerous, toxic fumes (HCN)
                                              AI-24

-------
                                                                             Acetonftrile
                               PRODUCTION DATA
Annual U.S.
 Production:   135 x 106 Ibs.

Fraction of
 Dispersion:    0.50

Release Rate (million Ibs/yr):  69.5
                      Consumption:  135 x 106 Ibs.

                      Fraction of Pro-
                        duction Lost:  0.015
Acute Toxicity
     LDSO

     LDLo
     LCLo
         TOXICITY DATA

  Dosage               Animal
3800 mg/kg            rat
1920 mg/kg            mouse
 700 mg/kg            mouse
8000 ppm (4 hours)      rat
  Route
oral
intraperitoneal
subcutaneous
inhalation
Chronic Toxicity

   U.S. Occupational Standard:  TWA: 40 ppm



   Carcinogenicity:   Equivocal results from 2-year rat study.
   Mutagenicity:

   Teratogenicity:  Fetal malformations in rats, 0.2
      to 1.0 ml/kg intraperitoneal
   Other Chronic Effects:
      Growth retardation
      Metabolic disturbances
      Liver enlargement
                      TLV: 40 ppm
                                        AI-25

-------
Acetophenone
                                      CHEMICAL  NAME
    CAS Number:   98-86-2

    Chemical Name:    Acetophenone
    Synonyms:   1-Phenyl-ethanone
                Methyl phenyl ketone
                Phenyl methyl ketone
    Molecular    	
      Formula:   C8H8O
Acetylbenzene
Hypnone
                       O
    Structure:   CH
     Chemical Properties

       Molecular Weight:   120.16

       Vapor Pressure:  1 mm at 37.1°C

       Boiling Point:   202.0°C

       Density:  1.0281 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:
        Physical State:  Liquid or solid

        Vapor Density: 4.14

        Melting Point:  20.5°C

        Solubility:   Insoluble (H2O)
     Environmental Persistence

        BOD:

        Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fire-slight
                                              AI-26

-------
                                                                       Acetophenone
                              PRODUCTION DATA

Annual U.S.
 Production:  2.68 x 10° Ibs.                     Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:   0.01                               duction Lost: °-015

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal               Route
     LD50                900mg/kg            rat                 oral
                         200 mg/kg            mouse              intraperitoneal
Non-lethal Acute Effects:
     Dermatitis
     Narcosis
     CNS depressant
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                       AI-27

-------
Acetylene
                                     CHEMICAL  NAME
    CAS Number:   74-86-2

    Chemical Name:    Acetylene
    Synonyms:   Ethyne
               • Ethine

    Molecular
      Formula:   C2H2
    Structure:    HC = CH
    Chemical Properties

       Molecular Weight:  26.04

       Vapor Pressure: 5600 mm at 16.8°C
       Boiling Point:   -84.0°C at 760 mm (sublimes)
       Density:  0.6181 at -32°C/4°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:  Gas

Vapor Density:  0.91

Melting Point:  -80.8°C

Solubility:   Slight (H2O)
     Safety Hazard:   Fire-dangerous
                   Explosion-moderate
                                             AI-28

-------
                                                                                Acetylene
                                PRODUCTION DATA
Annual U.S.
 Production:,   538 x 10s Ibs. (1974)

Fraction of
 Dispersion:     0.01

Release Rate (million Ibs/yr):  9.1
                      Consumption:   617 x 106 Ibs.

                      Fraction of Pro-
                       duction Lost:  0.015
Acute Toxicity
 N on-lethal Acute Effects:
       Nausea
       Cyanosis
       CNS depression
        TOXICITY DATA


90,000 ppm
Animal
rat
  Route
inhalation
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
            Intoxication:        100,000 ppm            man (slight)
                              200,000 ppm            man (marked)
            Incootdination:      300,000 ppm.           man
            Unconsciousness:    350,000 ppm (5 minutes)  man
                                         AI-29

-------
Acetylene tetrabromide
                                    CHEMICAL  NAME
    CAS Number:    79-27-6

    Chemical Name:     1,1,2,2-Tetrabiomoethane

    Synonyms:   Acetylenetetiabromide
                Muthmann's liquid

    Molecular
     Formula:   C2H2Br4
                   Br   Br
                    !    I
    Structure:   H - C - C - H
                    I    I
                   Bi   Bi
    Chemical Properties

       Molecular Weight:    345.67

       Vapor Pressure:   1 mm at 65°C

       Boiling Point:    243:S°C at 760 mm

       Density:    2.9656 at 20°C/4°C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
           Disaster hazard-dangerous-toxic fumes of carbonyl bromide when heated
Physical State:   Liquid

Vapor Density:

Melting Point:    0°C

Solubility:    Insoluble (H2O)
                                            AI-30

-------
                                                      Acetylene  tetrabromide
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                   Consumption:

                   Fraction of Pro-
                     duction Lost:
                               TOXICITY DATA
Acute Toxicity
       LD50
Non-lethal Acute Effects:
       Irritant
       Narcotic
 Dosage
400 rng/kg
400mg/kg
Animal
 rabbit
 guinea pig
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA l ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                    TLV:
 Route
oral
oral
                                      AI-31

-------
Acetylene tetrachloride
                                    CHEMICAL  NAME
    CAS Number:   79-34-5

    Chemical Name:    1,1,2,2 ,-Tetrachloioethane

    Synonyms:  Acetylene tetrachloride
    Molecular
     Formula:
                    Cl   Q
                    I     I
    Structure:   H - C - C - H
                    I     I.
                    a   a
    Chemical Properties

       Molecular Weight:  167.85

       Vapor Pressure:  6.75 mm at 25°C

       Boiling Point:    146.2°C at 760 mm

       Density:  1.5953 at 20°C/4°C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:  Liquid

Vapor Density:
Melting Point:   -43.8°C

Solubility:   Slightly (H2O)
    Safety Hazard:
          Explosion-moderate if contact with Na 01K
                                            AI-32

-------
                                                        Acetylene tetrachloride
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
Acute Toxicity
      LC
        •Lo
         TOXICITY DATA

   Dosage               Animal
  30 mg/kg             mouse
 700 mg/kg             dog
  50 mg/kg             dog
 500 mg/kg             rabbit
1000 ppm (4 hours)       rat
Non-lethal Acute Effects:
     Central nervous system
        TDLo               30 mg/kg
                      human
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 5 ppm



   Carcinogenicity:


 .  Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
  Route
intraperitoneal
oral
intravenous
subcutaneous
inhalation
oral
                                       AI-33

-------
Acrotein
    CAS Number:   107-02-8

    Chemical Name:   Acrolein
    Synonyms:  2-Propenal
                Acrylic aldehyde
                Allyl aldehyde
    Molecular   	
      Formula:
                                      CHEMICAL  NAME
                                     Acraldehyde
Structure:   CH, = C
                              . O
     Chemical Properties

        Molecular Weight:  56.06

        Vapor Pressure: 288.2 mm at 25°C

        Boiling Point:  S2.5°C

        Density:  0.8410 at 20°C/4°C

        Octanol/Water Parti'
         tion Coefficient:

     Environmental Persistence

        BOD:
                                                 Physical State: Liquid

                                                 Vapor Density: 1.94

                                                 Melting Point:  -86.95°C

                                                 Solubility:  Very soluble,  (400,000 mg/1 of H2O)
            33% of theoretical after 10 days

   Atmospheric Reactivity:   Reactive with oxidizing materials
     Safety Hazard:  Fire-dangerous
                                              AI-34

-------
                                                                                   Acrolein
Annual U.S.
 Production:   61.73 x 106 Ibs.

Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr):
                                PRODUCTION DATA
                      Consumption:
                       Fraction of Pro-
                        duction Lost: o.ois
Acute Toxicity
      LDSO
         TOXICITY DATA

                       Animal
  46 mg/kg            rat
  50 mg/kg            tat
  30 mg/kg            mouse
   7 mg/kg            rabbit
 562 mg/kg            labbit
   2 mg/kg            mouse
 150 mg/kg            rabbit
 150 mg/kg            guinea pig
 153 ppm (10 minutes)  . human
   8 ppm (4 hours)      rat
  24 mg/m3 (6 hours)    mouse
1570 mg/m3 (8 hours)    cat
  24 mg/m3 (6 hours)    rabbit
  24 mg/m3 (6 hours)    guinea pig
  Route
oral
subcutaneous
subcutaneous
oral
skin
intraperitoneal
subcutaneous
subcutaneous
inhalation
inhalation
inhalation
inhalation
inhalation
inhalation
Chronic Toxicity

   U.S. Occupational Standard:  TWA: 0.1 ppm



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                       TLV: 0.1 ppm
Lachrymation
Irritant to respiratory tract
CNS damage
                                         AI-35

-------
Acrylamide
                                     CHEMICAL  NAME
    CAS Number:   79-06-1

    Chemical Name:    Acrylamide

    Synonyms'.     Propenoic acid, amide
                  Piopenamide
                  Acrylic amide
    Molecular
      Formula:  C3H5NO
                             O
    Structure:   CH2  =  CH - C -  NH2
    Chemical Properties

       Molecular Weight:     71.08

       Vapor Pressure:     1.6 mm at 84.5°C

       Boiling Point:   125°Cat25mm

       Density:     1.122 at 30°C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Disaster hazard-moderate-emits acrid fumes
Physical State:     Solid

Vapor Density:

Melting Point:   84 to 85°C

Solubility:   Very soluble (H2O)
                                             AI-36

-------
                                                                          Acrylamide
Annual U.S.
 Production:    35 x 106 Ibs.

Friction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
                0.015
Acute Toxicity
      LDSO
      LD
        Lo
 Non-lethal Acute Effects:
      CNS paralysis
 170 mg/kg
 170 mg/kg
 126 mg/kg
1000 mg/kg
 252 mg/kg
                                 TOXICITY DATA
Animal
rat
mouse
rabbit
rabbit
guinea pig
Chronic Toxicity

   U.S. Occupational Standard:  (aii) TWA 0.3 mg/m3



   Carcinogenicity:
  Route
oral
oral
oral
skin
oral
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:   0.3 mg/m3 (skin)
                                       AI-37

-------
Acrylic  acid
                                      CHEMICAL NAME
    CAS Number:   79-10-7

    Chemical Name:    Acrylic acid
    Synonyms:  Acioleic acid
                Propene acid
                2-Propenoic acid
    Molecular	
      Formula:  G3H4O2
    Structure:   H2C = CH - C
                               O
                               OH
     Chemical Properties

       Molecular Weight:   72.06

       Vapor Pressure:  4.61 mmat25°C

       Boiling Point:   141°C

       Density:  1.0511 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:   0.43
Physical State:  Liquid

Vapor Density: 2.45

Melting Point:  13°C

Solubility:  Infinite (H2O)
     Environmental Persistence

        BOD:

        Atmospheric Reactivity:  Reacts with oxidizing material
     Safety Hazard:  Fire-slight
                   Explosion-moderate, spontaneous polymerization
                   Disaster hazard-dangerous, toxic fumes
                                              AI-38

-------
                                                                             Acrylic  acid
                               PRODUCTION DATA
Annual U.S.
 Production:   233 x 106 Ibs. (1974)

Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr): 2.7
                                               Consumption:

                                               Fraction of Pro-
                                                 duction Lost: 0.015
                                  TOXICITY DATA
Acute Toxicity
      LDLo
                          340 mg/kg
                           60 mg/kg
                          280 mg/kg
                          128 mg/kg
                         6000 ppm (5 hours)
Non-lethal Acute Effects:
      Irritant to eyes and skin
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
iat
mouse
rabbit
mouse
rat
  Route
oral
oral
skin .
intraperitoneal
inhalation
                                               TLV: unconfirmed
                                         AI-39

-------
Acrytonitrile
    CAS Number:   107-13-1

    Chemical Name:   Acrylonitrile
    Synonyms:   2-Propenenitrile
                Vinyl cyanide
    Molecular
      Formula:
                                      CHEMICAL  NAME
    Structure:   CH2 =  CH - C = N
    Chemical Properties

       Molecular Weight:  53.00

       Vapor Pressure:  113.8mmat25°C

       Boiling Point:   77.5°C

       Density:  0.8060 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:  -0.92
Physical State:  Liquid

Vapor Density: 1.83

Melting Point:  -83 to -84°C

Solubility:   Soluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Fire-dangerous
                   Explosion—moderate
                                              AI-40

-------
                                                                              Acrylonitrile
                                PRODUCTION DATA

Annual U.S.
 Production:   1411.8 x 10* Ibs. (1974)             Consumption:  511.7 x 106 Ibs. (1974)
Fraction of
 Dispersion:   0.01

Release Rate (million Ibs/yr): 27.4 (1972)
                       Fraction of Pro-
                        duction Lost: 0.015
                                  TOXICITY DATA
Acute Toxicity
     LDSO
      LDLo
      LCSo
      LCLo
   Dosage
 93 mg/kg
 96mg/kg
 93 mg/kg
280 mg/kg
250 mg/kg
 15 mg/kg
784 ppm (1 hour)
576 ppm (4 hours)
500 ppm (4 hours)
120 mg/kg (4 hours)
600 ppm (4 hours)
258 ppm (4 hours)
  Animal
 rat
 rat
 rabbit
• tabbit
 guinea pig
 mouse
 mouse
 guinea pig
 rat
 dog
 cat
 rabbit
   Route
oral
subcutaneous
oral
skin
skin
intraperitoneal
inhalation
inhalation
inhalation
inhalation
inhalation
inhalation
Chronic Toxicity

   U.S. Occupational Standard:  TWA: 20 ppm


   Carcinogenicity:


   Mutagenicity:

   Teratogeniciry:

   Other Chronic Effects:
                       TLV: 20 ppm (skin)
Inhibits respiratory enzyme
Irritation of eyes and nose
Anemia and leucocytosis
Affects liver and kidney
     Odor perception:  21.4 ppm
                                         AI-41

-------
Adipic acid
                                      CHEMICAL  NAME


    CAS Number:   124-04-9
    Chemical Name: Adipic acid

    Synonyms:   Hexanedioic acid        ~
                1,4-Butane dicarboxylic acid
                Adipinic acid
    Molecular
      Formula:   C6H10O4;
                CH, - CH, - COOH
    Structure:   I
                CH2 - CH2 - COOH
     Chemical Properties

       Molecular Weight:   146.14                       Physical State:  Solid

       Vapor Pressure:     1 mm at 159.5°C              Vapor Density: 5.04

       Boiling Point:   337.5°C                         Melting Point:  153°C
       Density:  1.360 at 25°C/4°C             ,         Solubility:  Slightly, (15 gm/1 of H2O)

       Octanol/Water Parti-
         tion Coefficient: -°-14

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:  Fire-slight
                                              AT-A9

-------
                                                                           Adipic acid
                              PRODUCTION DATA

Annual U.S.
 Production:   1478.4 x 106 Ibs. (1974)            Consumption:   1475 x 10* Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:   0.01                               duction Lost:  0.015

      Rate (million Ibs/yr): 37.3
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDSo              1900 mg/kg            mouse              oral
     LDLo              3600 mg/kg            rat                 oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-43

-------
Alachlor

                                     CHEMICAL  NAME

    CAS Number:    15972-60-8
    Chemical Name:    2-Chloro-N-{2,6-diethylphenyl)-N-(methoxymethyl)acetamide
    Synonyms:  2-Chloro-2' ,6'-diethyl-N-(methoxymethyl)-acetanilide
               MethacMor
    Molecular
      Formula:  Ci4H20ClNO2
               CH3OCH2 - N -  C - CH2C1
    Structure:
                CH3CH2
    Chemical Properties
       Molecular Weight:  269.90                      Physical State:
       Vapor Pressure: 2.2 x Id"5 mm at 25°C           Vapor Density:
       Boiling Point:   100°C                          Melting Point:
       Density:                                      Solubility:    140 ppm  H2O
       Octanol/Water Parti-
         tion Coefficient:
    Environmental Persistence
       BOD:
       Atmospheric Reactivity:
    Safety Hazard:
                                             AI-44

-------
                                                                            Alachlor


                              PRODUCTION DATA
Annual U.S.
 Production:   20xl06lbs.                      Consumption:   20xl06lbs.

Fraction of                                    Fraction of Pro-
 Dispersion:   Estimated as 1.0                    (faction Lost:  0.01

Release Rate (million Ibs/yr):  20.2
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LD50              1200mg/kg            rat                oral
                        3000 mg/kg            mammal            oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:       ,                        TLV:

   Other Chronic Effects:
                                      AI-45

-------
Aldrin
                                       CHEMICAL  NAME
    CAS Number:   309-00-2
    Chemical Name: l>2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-hexahydro-endo,exo-l,4:5,8-diinethanonaphthalene

    Synonyms:  Octalene
                Aldrine
                Compound 118
    Molecular
      Formula:  Ci2H8Cl6
    Structure:    CH
     Chemical Properties

        Molecular Weight:  364.82

        Vapor Pressure: 2.31 x 10"5 Tom aT20°C

        Boiling Point:

        Density:

        Octanol/Water Parti-
         tion Coefficient:  5.00

     Environmental Persistence

        BOO:
       Atmospheric Reactivity:   Can be degraded anaeiobically
                               Aldrin -> dieldrin in the environment
     Safety Hazard:
Physical State:  Solid

Vapor Density:

Melting Point:  104°C

Solubility:  Insoluble (H2O)
                                               AI-46

-------
                                                                                      Aldrin
                                PRODUCTION DATA
Annual U.S.
 Production:   25 x 106 Ibs.

Fraction of
 Dispersion:    1-0

Release Rate (million Ibs/yr): 25.3 (1972)
                       Consumption:  25 x 106 Ibs.

                       Fraction of Pro-
                        duction Lost: 0.01
Acute Toxicity
     LD50
      LDLO
Non-lethal Acute Effects:
      Irritability
      Convulsions
      Liver damage
         TOXICITY DATA

                       Animal
 55 mg/kg             rat
200mg/kg             rat
 39 mg/kg             rat
 98 mg/kg             rat
 10 mg/kg             chicken
  7 mg/kg             wild bird
 15 mg/kg             rat
 63 mg/kg             mouse
 95 mg/kg             dog
  Route
oral
skin
oral
skin
oral
oral
skin
intraperitoneal
unknown
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinoganicity:
      Neoplagtic effects	
      TDjjo: 440 mg/kg (52 weeks)-mouse, oral
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                       TLV: 0.25 mg/m3 (skin)
                                         AI-47

-------
Allyl  alcohol
                                      CHEMICAL  NAME
    CAS Number:   107-18-6

    Chemical Name:    Allyl alcohol

    Synonyms:      2-Propen-l-ol
                   Vinyl carbinol

    Molecular
      Formula:   C3H6O
    Structure:   CH2 =  CH  - CH2OH
     Chemical Properties

       Molecular Weight:     58.08                     Physical State:     Liquid

       Vapor Pressure:  25.6 mmat 25°C                 Vapor Density:    2.00

       Boiling Point:   97°C                           Melting Point:  -129°C

       Density:     0.8540 at 20°C/4°C                  Solubility:  Infinite (H2O)

       Octanol/Water Parti-
         tion Coefficient:     0.13

     Environmental Persistence

       BOD:    9.1% of theoretical

       Atmospheric Reactivity:  . Reacts with oxidizing materials
     Safety Hazard:
          Fire—dangerous
          Explosion-moderate
          Disaster hazard-dangerous-toxic fumes
                                              AI-48

-------
                                                                             Allyl  alcohol
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                                PRODUCTION DATA
                        Consumption:

                        Fraction of Pro-
                         duction Lost:
                                  TOXICITY DATA
Acute Toxicity
      LD50
      LCSO
   Dosage
  42 mg/kg
  96 mg/kg
  42 mg/kg
  69 mg/kg
  43 mg/kg
  53 mg/kg
  53 mg/kg
  45 mg/kg
 165 ppm (4 hours)
1000 ppm (4 hours)
1000 ppm (4 hours)
Non-lethal Acute Effects:
      Irritant effects:
         TCLo              25 ppm
      Eyes and skin irritated
      Respiratory tract irritated
      Damage to kidney and liver
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 2 ppm
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
mouse
mouse
rat
dog
rabbit
rabbit
rabbit
rat
monkey
rabbit
                        human
  Route
intraperitoneal
oral
intraperitoneal
oral
oral
oral
skin
parenteral
inhalation
inhalation
inhalation
                    inhalation
                        TLV:   2 ppm (skin)
                                         AI-49

-------
Allyl chloride
                                      CHEMICAL  NAME
    CAS Number:   107-05-1

    Chemical Name:   3-Chloropropene

    Synonyms:  3-Chloroprene
                AC
                Chlorallylene
    Molecular
      Formula:  C3HSC1
                                  l-Chloro-2-propene
                                  3-Chloropropylene
                                  2-Chloropropylene
                                                      Physical State:  Liquid

                                                      Vapor Density:  2.64

                                                      Melting Point:  -134.5°C

                                                      Solubility:   SolubleTsl gm/1 H2O)
    Structure:  CH2 = CH - CH2 Cl
Chemical Properties

   Molecular Weight:  76.53

   Vapor Pressure: 359 mm at 25°C

   Boiling Point:   44.6°C

   Density: 0.938 at 20°C/4°C

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:
       Atmospheric Reactivity:  Umeactive to 02
                Reacts vigorously with oxidizing materials
                Reactive with 03, tvt = 9 hours, yielding formaldehyde and 2-chloroacetaldehyde
                Reactive with OH, ty, = 21 hours, yielding 2-chloroacetaldehyde
     Safety Hazard:  Fire-highly dangerous
                   Explosion—moderate
                                               AI-50

-------
                                                                           Altyl chloride
                               PRODUCTION DATA
Annual U.S.
 Production:   295.0 x 106 Ibs.

Fraction of
 Dispersion:    0

Release Rate (million Ibs/yr):  4.4 (1972)
                      Consumption:  29S.O x 10  Ibs.

                      Fraction of Pro-
                       duction Lost: 0.0IS
                                 TOXICITY DATA
Acute Toxicity
      LD50


      LDLo
                           Dosage
                          155 mg/kg
                         7150 mg/kg
                         2200 mg/kg
                           64 mg/kg
                          290 ppm (8 hours)
                         6360ppm
                      Animal
                      mouse
                      dog
                      rabbit
                      tat
                      rat
                      guinea pig
      Pulmonary hemorrhage
Chronic Toxicity

   U.S. Occupational Standard:  TWA: 1 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:  Ippm
Irritation of eyes, nose, and throat
Degeneration of liver and kidney
  Route
intrapedtoneal
intravenous
skin
oral
inhalation
inhalation
                                        AI-51

-------
Allylene
                                      CHEMICAL  NAME
    CAS Number:    74-99-7

    Chemical Name:    Propyne

    Synonyms:   Allylene
                Methylacetylene
                Propine
    Molecular
     Formula:   C3H4
    Structure:   CH3 - C  = CH
    Chemical Properties

       Molecular Weight:  40.07

       Vapor Pressure:  3876 mm at 20°C

       Boiling Point:    -23.2°C at 760 mm

       Density:  0.7062 at -50°C/4°C

       Octanol/Water Parti-
        tion Coefficient:
Physical State:     Gas

Vapor Density:  1.38

Melting Point:   -101.5°C

Solubility:   Slightly (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts violently with oxidizing materials
    Safety Hazard:
          Fire-dangerous
          Explosion-moderate
                                              AI-52

-------
                                                                               Allylene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                                              Consumption:

                                              Fraction of Pro-
                                               duction Lost:
Acute Toxicity
                                 TOXICITY DATA

                           Dosage               Animal
                                                                   Route
Non-lethal Acute Effects:
      Anesthetic
      Asphyxiant in nigh concentrations
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                              TLV:
                                       AI-53

-------
Ally!  naphthalene
                                     CHEMICAL  NAME
    CAS Number:   2489-86-3

    Chemical Name:    1-Ally[naphthalene

    Synonyms:  3-a-Naphthylpropene
    Molecular
      Formula:
    Structure:
                       CH2CH  =  CH2
    Chemical Properties

       Molecular Weight:  168.24

       Vapor Pressure:

       Boiling Point:   265 to 267°C

       Density:  1.0228 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:  Solid

Vapor Density:

Melting Point:

Solubility:
                                           .  AI-54

-------
                                                               Allyl  naphthalene
Annual U.S.
 Production:
Fraction of
 Dispersion:
Release Rate (million Ibs/yr):
                             PRODUCTION DATA
             Consumption:
             Fraction of Pro-
              duction Lost:
Acute Toxicity
Chronic Toxicity
   U.S. Occupational Standard:

   Carcinogenicity:

   Mutagenlcity:
   Teratogenicity:
   Other Chronic Effects:
TOXICITY DATA
             Animal
             TLV:
Route
                                      AI-55

-------
Amiben
                                     CHEMICAL  NAME
    CAS Number:    133-904

    Chemical Name:    3-Amino-2,5-dichlorobenzoicacid

    Synonyms:   2,5-Dichloro-3-aminobenzoic acid
    Molecular
     Formula:   C7HSC12NO2
                 NH2      a    o

Structure:       '     /y\_  C

                     '           OH
                 a


Chemical Properties

   Molecular Weight:   205.96

   Vapor Pressure: Negligible at 25°C

   Boiling Point:

   Density:

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
                                                    Physical State:    Solid

                                                    Vapor Density:

                                                    Melting Point:   201°C

                                                    Solubility:   700 ppm (H2O)
    Safety Hazard:
          Disaster hazard-dangerous-toxic fumes
                                             AI-56

-------
                                                                              Amibeii

                              PRODUCTION DATA
Annual U.S.
 Production:   20 x 106 Ibs.                      Consumption:  20 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:   1.0                              duction Lost:    0.01

Release Rate (million Ibs/yr):    20.2
                                TOXICITYDATA

Acute Toxicity              Dosage               Animal               Route
     LD50              5620 mg/kg            rat                 oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-57

-------
p-Aminobenzoic acid
                                    CHEMICAL NAME
    CAS Number:   150-13-0

    Chemical Name:    p-Aminobenzoic acid

    Synonyms:  PABA
               Paraminol

    Molecular
      Formula:  C7H,NO2
    Structure:
    Chemical Properties

       Molecular Weight:     137.14

       Vapor Pressure:

       Boiling Point:

       Density:   1.374 at 25°C/4°C

       Octanol/Water Parti-
        tion Coefficient:  0.89

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:     Solid

Vapor Density:

Melting Point:   188 to 189°C

Solubility:   Soluble (hot H2O)
                                            AI-58

-------
                                                            p-Aminobenzoic acid
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
      LDSo              2850 mg/kg            mouse              oral
                        1830 mg/kg            rabbit              oral
                        2000 mg/kg            rabbit              intervenous
      LDLo              6000 mg/kg            rat                 oral
                        1000 mg/kg            dog                oral

Non-lethal Acute Effects:
      Methemoglobinemia
      Hepatitis
Chronic Toxicity

   U.S. Occupational Standard:



   Careinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-59

-------
p-Aminobiphenyl
                                    CHEMICAL  NAME
    CAS Number:    92-67-1

    Chemical Name:    4-Biphenylamine

    Synonyms:   4-Aminobiphenyl
                Xehylamine
                p-Biphenylamine
    Molecular
      Formula:   Ci2HuN
    Structure:
    Chemical Properties

       Molecular Weight:   169.23

       Vapor Pressure:

       Boiling Point:   302°C

       Density:   1.160 at 20°C/20°C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
         .  Disaster hazard-moderate-toxic fumes
Physical State:      Solid

Vapor Density:

Melting Point:   53to54°C

Solubility:   Slightly (H2O)
                                            AI-60

-------
                                                                  p-Aminobiphenyl
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSO              500 mg/kg             rat   .              oral
                         250 mg/kg             mouse              intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard: (aii) Carcinogen
   Carcinogenicity:
      TDLo             5200 mg/kg (52 weeks)    rat                 oral
                           4 g/kg               rat                 subcutaneous
                         140 mg/kg (7 days)      mouse              oral
                         216 mg/kg (3 days)      mouse              subcutaneous
                         680 mg/kg (3 years)      dog                oral

   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                       AI-61

-------
Aminoethylethanolamine
                                    CHEMICAL  NAME


    CAS Number:   11141-1
    Chemical Name:   2 [(2-Aminoethyl)amino] ethanol

    Synonyms:  (2-Hydroxyethyl)-ethylenediamine
               N-Aminoethylethanolamine

    Molecular
     Formula:  C4H12N2O
                	          H
    Structure:      H2N - CH2 - CH2 - N  - CH2  - CH2OH
    Chemical Properties

       Molecular Weight:  104.16                      Physical State:     Liquid

       Vapor Pressure:    <0.01 mmat20°C            Vapor Density:     3.59

       Boiling Point:   243.7°C at 760 mm              Melting Point:

       Density: ~0.9556 at 25°C/4°C                   Solubility:  Very soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:
          Fire—moderate
                                           AI-62

-------
                                                    Aminoethylethanolamine
Annual U.S.
 Production:   13.5 x 106 Ibs.

Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                    Consumption:
                    Fraction of Pro-
                      duction Lost:    0.015
                               TOXICITY DATA
Acute Toxicity
     LDSO
  Dosage
3000 mg/kg
1800mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
guinea pig
                    TLV:
  Route
oral
skin
                                     AI-63

-------
Amyl acetate
                                     CHEMICAL NAME
    CAS Number:   628-63-7
    Chemical Name: Acetic acid, pentyl ester

    Synonyms:  Isoamyl acetate      Acetic acid
               Banana oil          "Amylacetic estef
               IsopentyFacetafe"
    Molecular   	
      Formula:  C7H14O2
    Structure:
               CH,-C.
                             (CH2)2 - CH
                                          CH,
                                        x   J
                                          CH,
    Chemical Properties

       Molecular Weight:  130.2

       Vapor Pressure: 9.43 mm at 25°C

       Boiling Point:   142.0°C

       Density: 0.876 at 15°C/4°C

       Octanol/Water Parti-
         tion Coefficient:
Physical State:  Liquid

Vapor Density:  4.49

Melting Point:

Solubility:  Slight (H2O)
     Environmental Persistence

       BOD:   "38%~of"the"oreticai

       Atmospheric Reactivity:  Reacts with reducing material
     Safety Hazard:  Fire-dangerous
                  Explosion—moderate
                                              AI-64

-------
                                                                          Amyl acetate
                               PRODUCTION DATA

Annual U.S.
 Production:   7.6 x 106 Ibs. (1964)                Consumption:

Fraction of                                      Fraction of Pro-	
 Dispersion:    1.0                                duction Lost:  0.01S

Release Rate (million Ibs/yr):  7.6
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
      LD50               7400mg/kg            rabbit              oral
      LDLo               ISOOmg/kg            rat                 intraperitoneal
      LCLo               5200 ppm

 Non-lethal Acute Effects:
      Irritant effects-TCL0 188 ppm (30 minutes) human inhalation
      Inhalation-1000 ppm (30 minutes) causes headache, fatigue, chest oppression
      Irritant-eyes and mucous membranes of nose and throat
Chronic Toxicity

   U.S. Occupational Standard:  TWA: 125 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:  100 ppm

   Other Chronic Effects:
                                         AI-65

-------
Amyl alcohol
                                     CHEMICAL  NAME
    CAS Number:    71-41-0

    Chemical Name:     Pentyl alcohol

    Synonyms:    n-Amyl alcohol
                 1-Pentanol
                 Primary amyl alcohol
    Molecular
      Formula:    CsHI2O
 Butyl carbinol
    Structure:   CH3  - CH2  - CH2  - CH2  - CH2OH
     Chemical Properties

       Molecular Weight:   88.15

       Vapor Pressure:  3.16 mm at 25°C

       Boiling Point:    137.3°C at 748 mm

       Density:  0.8144 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:   1-56

     Environmental Persistence

       BOD:    84% of theoretical

       Atmospheric Reactivity:
     Safety Hazard:
           Fire-moderate
           Explosion-moderate
Physical State:   Liquid

Vapor Density:   3.04

Melting Point:    -79°C

Solubility:    Insoluble (H2O)
                                            AI-66

-------
                                                                        Amyl alcohol
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
       LDSO               3030mg/kg            rat                 oral
                           200 mg/kg            mouse              oral
       LDLo                490 mg/kg            rat                 intiaperitoneal
                          1390 mg/kg            dog                oral

 Non-lethal Acute Effects:
       Vapor irritant to eyes and upper respiratory tract
       Following ingestion:
            Headache
            Nausea and vomiting
            Delirium
            Methemoglobin formation
Chronic Toxicity

   U.S. Occupational Standard:                  ,


   Carcinoganicity:


   Mutagenicity:

   Teratogenlcity:                               TLV:  100 ppm

   Other Chronic Effects:
                                        AI-67

-------
Amylamines
                                    CHEMICAL  NAME
    CAS Number:   110-58-7

    Chemical Name:   Pentylamine

    Synonyms:  Amylamine (mixed isomers)
               Aminopentane

    Molecular
     Formula:  C5Hi3N
Structure:
                                     (1 -  amyl  amine)
    Chemical Properties  (1-amylamine)

       Molecular Weight:  87.17

       Vapor Pressure:

       Boiling Point:   104.4°C at 760 mm

       Density:  0.7547 at 20°C/4°C

       Octanol/Water Parti-
        tion Coefficient:  1-05
                                               Physical State:  Liquid

                                               Vapor Density:  3.01

                                               Melting Point:  -55°C

                                               Solubility:  Infinite (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire—dangerous
                                             AI-68

-------
                                                                       Amylamines
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
Acute Toxicity
      (Mixed isomers)
        LDSo

        LCLo
        TOXICITY DATA

  Dosage              Animal
 470 mg/kg
1120mg/kg
2000 ppm (4 hours)
rat
rabbit
rat
  Route

oral
skin
inhalation
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
      Strong irritant
                     TLV:
                                       AI-69

-------
Amyl  chloride
                                     CHEMICAL  NAME
    CAS Number:    543-59-7

    Chemical Name:    1-Chloropentane

    Synonyms:   n-Amylchloride
                Pentylchloride

    Molecular
      Formula:   C5HnCl
    Structure:
    Chemical Properties

       Molecular Weight:   106.6                        Physical State:   Liquid

       Vapor Pressure:  10 mm at 25°C                   Vapor Density:  3.67

       Boiling Point: 107.8°C at 760 mm                  Melting Point:   -99°C

       Density:  0.8818 at 20°C/4°C                    Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire -dangerous
          Explosion-explosive if mixed with air
          Disaster hazard— dangerous-emits toxic fumes (phosgene)
                                              AI-70

-------
                                                                     Amyl chloride
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibt/yr):
                              PRODUCTION DATA
                   Consumption:

                   Fraction of Pro-
                    duction Lost:
Acute Toxicity
 Non-lethal Acute Effects:
      Narcotic
      Local irritant
      TOXICITY DATA

Dosage              Animal
Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:    Not tested


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                   TLV:
                                      AI-71

-------
Amylene

                                     CHEMICAL  NAME

    CAS Number:    109-67-1
    Chemical Name:    1-Pentene
    Synonyms:  Amylene
               Piopyl ethylene
    Molecular
      Formula:  C5H10
    Structure:   CH3CH2CH2CH = CH2
    Chemical Properties
       Molecular Weight:   70.14                       Physical State:  Gas-liquid
       Vapor Pressure:    858.0 mm at 25°C             Vapor Density. 2.42
       Boiling Point:   29.968°Cat760mm              Melting Point:  -138°C
       Density: 0.6405 at 20°C/4°C                    Solubility:   Insoluble (H2O)
       Octanol/Water Parti-
        tion Coefficient:
    Environmental Persistence
       BOO:
       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:
          Fiie-dangerous toxic fumes
                                             AI-72

-------
                                                                             Amylene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
             Consumption:

             Fraction of Pro-
              duction Lost:
Acute Toxicity
TOXICITY DATA

              Animal
Route
Non-lethal Acute Effects:
     Narcotic .
     Asphyxiant
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
             TLV:
                                       AI-73

-------
Amyl ether
                                    CHEMICAL  NAME
   CAS Number:   693-65-2

   Chemical Name:    Pentyl ether

   Synonyms:   Amyl ether
               Amyl oxide
               Diamyl ether
   Molecular
     Formula:   C10H22O
   Structure:  CH3(CH2)4 - O - (CH2)4 - CH3
    Chemical Properties

       Molecular Weight:   158.29                      Physical State:   Liquid

       Vapor Pressure:                                Vapor Density:  5.46

       Boiling Point:    190°C at 760 mm                Melting Point:   -69°C

       Density:  0.7833 at 20°C/4°C                   Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-moderate
                                             AI-74

-------
                                                                        Amyl ether
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:.

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                      AI-75

-------
A my I mercaptan
                                     CHEMICAL  NAME
    CAS Number:     110-66-7

    Chemical Name:   l-Pentane thiol

    Synonyms:
    Molecular
      Formula:
Amyl mercaptan
Amyl hydrosulfide
Amy sulfhydrate

C5H12S
Amyl thio alcohol
n-Thioamyl alcohol
    Structure:
    Chemical Properties

       Molecular Weight:   104.22

       Vapor Pressure:   13.8 mm at 25°C

       Boiling Point:  112.9°C at 760mm

       Density:   0.8327 at 20°C/4°C

       Octanol/Water Parti-
        tion Coefficient:
                                   Physical State:   Liquid

                                   Vapor Density:   3.59

                                   Melting Point:   -169°C

                                   Solubility:    Insoluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
    Safety Hazard:
           Fiie—dangerous
                                             AI-76

-------
                                                                  Amyl  mercaptan
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                    Consumption:

                    Fraction of Pro-
                      duction Lost:
                                TOXICITY DATA
Acute Toxicity
  Dosage
2000 ppm (4 hours)
Animal
 rat
 Non-lethal Acute Effects:
       Irritant to eyes and skin
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                    TLV:
 Route
inhalation
                                      AI-77

-------
Aniline
                                       CHEMICAL  NAME
    CAS Number:   62-53-3

    Chemical Name:    Aniline
    Synonyms:  Benzenamine
                Aminobenzine
                Aminophen
    Molecular   	
      Formula:  C6H7N
Benzamine
Phylamine
Aniline oil
    Structure:
     Chemical Properties

        Molecular Weight:  93.12

        Vapor Pressure: 0.67 mm at 2S°C

        Boiling Point:   184°C

        Density:  1.02173 at 20°C/4°C

        Octanol/Water Parti-
         tion Coefficient:  1.24

     Environmental Persistence

        BOO:

        Atmospheric Reactivity:   Reacts with oxidizing materials
            Physical State:  Liquid

            Vapor Density: 3.22

            Melting Point:  -6-3
            Solubility:   Soluble, (36.5 gm/1 of H2O)
              •  Photochemically degraded to n-methylaniline, N,N-dimethylariiline, acetanilide, phenol, and
                isomeric hydroxy anilines
     Safety Hazard:  Fire-moderate
                   Disaster hazard—dangerous, toxic fumes
                                               AI-78

-------
                                                                                     Aniline
                                PRODUCTION DATA

Annual U.S.
 Production:   55i.2x 106 Ibs. (1974)               Consumption:  480xl06lbs.
Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr): 6.15
                       Fraction of Pro-
                         duction Lost: 0.015
Acute Toxicity
     LD50
      LDLo
      LCSO
      LCLo

Chronic Toxicity
                                  TOXICITY DATA
   Dosage
 440 mg/kg
 1400 mg/kg
 420 mg/kg
 820 mg/kg
  64 mg/kg
 1290 mg/kg
 350 mg/kg
 357 mg/kg
 480 mg/kg
 1540 mg/kg
 1750 mg/kg
 1540 mg/kg
 200 mg/kg
 1000 mg/kg
 1750 mg/kg
 175 ppm (7 hours)
 250 ppm (4 hours)
 180 ppm (8 hours)
 Animal
rat
rat
rat
rabbit
rabbit
guinea pig
human
human
mouse
dog
caf
cat
rabbit
rabbit
guinea pig
mouse
rat
cat
   Route
oral
skin
intraperitoneal
skin
intravenous
skin
oral
unreported
subcutaneous
skin
oral
skin
intraperitoneal
subcutaneous
skin
inhalation
inhalation
inhalation
   U.S. Occupational Standard:  TWA: 5 ppm
   Carcinogenicity:    Neoplastic effects-papillomas and benign bladder tumors
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                       TLV: 5 ppm (skin)
Nephrosis
Blood effects
Enzyme and hormone effects
                             Odor perception: 0.2 3'ppm
                                         AI-79

-------
Aniline hydrochloride
                                     CHEMICAL  NAME
    CAS Number:   142-04-1

    Chemical Name:    Aniline hydrochloride
    Synonyms:
    Molecular
     Formula:
Aniline chloride
Benzenamine hydiochloride
Aniline salt
                  C6H7N-HC1
    Structure:
    Chemical Properties

       Molecular Weight:     129.60

       Vapor Pressure:

       Boiling Point:   24S°C at 760 mm

       Density: 1.2215 at 4°C

       Octanol/Water Parti-
        tion Coefficient:
                                  Physical State:     Solid

                                  Vap or Density:  1.22 at 4° C

                                  Melting Point:   198°C

                                  Solubility:   Very soluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:
          Fire-slight
          Disaster hazard-dangerous if heated with acid; aniline and chlorine fumes
                                              AI-80

-------
                                                             Aniline hydrochloric!e
                               PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LD50               1072 mg/kg             rat                 oral
                          841 mg/kg             mouse              oral
                          750 mg/kg             mouse              intraperitoneal
                          500 mg/kg             rat                 intraperitoneal
 Non4ethal Acute Effects:
      Depression of CNS
      Methemoglobinemia
      Hemolysis
      Stimulation of bone marrow
      Liver damage
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-81

-------
Anisidine  (o  and p)
                                      CHEMICAL  NAME
    CAS Number:   104-97-9(p); 90-04-0(o)

    Chemical Name:
                      p-Anisidine; o-Anisidine
    Synonyms:   o-Methoxyaniline
                o-Aininoanisole

    Molecular
      Formula:   C7H9NO
    Structure:
     Chemical Properties

       Molecular Weight:   123.16

       Vapor Pressure:  1 mm at 61°C
       Boiling Point:   224°C at 760 mm (o)
                      243°C at 760 mm (p)
       Density:  1.0923 at 20°C/4°C(o)
                1.071 at 57°C/4°C(p)
       Octanol/Water Parti-
         tion Coefficient:   1.65

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
          Disaster hazard-dangerous, toxic fumes
p-Methoxy aniline
p-Aminoanisole
1 -Amino-4-methoxy benzene
Physical State:  Liquid

Vapor Density:

Melting Point:  6.22°C (o)
              57.2°C (p)	
Solubility:   Soluble (H2O) (p)
            Slightly soluble (H2O) (o)
                                              AI-82

-------
                                                                 Anisidine  (o  and  p)
                               PRODUCTION DATA

Annual U.S.
  Production:   2.3 x 106 Ibs. (total, 1967)           Consumption:

Fraction of                                      Fraction of Pro-
  Dispersion:                                      duction Lost:     0.015

Release Rate (million Ibs/yr):
                                  TOXICITY DATA

 Acute Toxicity               Dosage               Animal              Route
      (p-Anisidine)
         LD50            1400mg/kg            rat                 oral
	1400 mg/kg            rat                 intraperitoneal
 Non-lethal Acute Effects:
      Irritant to skin .
 Chronic Toxicity

   U.S. Occupational Standard: (o and p isomers) (air) TWA 0.5 irig/rn3
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                tlV:   0.5 mg/m3 (skin)

   Other Chronic Effects:
                                        AI-83

-------
Anisole
    CAS Number:    100-66-3

    Chemical Name:  Anisole

    Synonyms:    Methoxy benzene
                  Methylphenyl ether
                  Phenylmethyl ether
    Molecular
      Formula:    C7H8O
                                      CHEMICAL  NAME
    Structure:
                       OCHq
     Chemical Properties

        Molecular Weight:  108.15

        Vapor Pressure:   10 mm at 42.2°C

        Boiling Point: 155°C

        Density:   0.9961 at 20°C/4°C

        Octanol/Water Parti-
         tion Coefficient:    2-27
Physical State:   Liquid

Vapor Density:  3.72

Melting Point:   -37.5°C

Solubility:    Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts towards oxidizing materials
     Safety Hazard:
            Fire-moderate
                                              AI-84

-------
                                                                              Anisole


                              PRODUCTION DATA
Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
       LD50              3700mg/kg            rat                oral
                         2800 mg/kg            mouse             oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Not tested


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-85

-------
Anthranilic acid
                                     CHEMICAL NAME
    CAS Number:    118-92-3

    Chemical Name:     Anthranilic acid

    Synonyms:    O-Aminobenzoic acid
                 2-Aminobenzoic acid

    Molecular
      Formula:    C7H7NO2
    Structure:
NH2



C - OH
II
O
    Chemical Properties

       Molecular Weight:   137.14

       Vapor Pressure:

       Boiling Point:    Sublimes

       Density:      1.412 at 20°C

       Octanol/Water Parti-
         tion Coefficient:   1-73

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
           Fire-slight
                             Physical State:   Solid

                             Vapor Density:

                             Melting Point:   146 to 1479C

                             Solubility:   Soluble (H2O)
                                        Very soluble (hot H2O)
                                             AI-86

-------
                                                                  Anthranilic acid
                              PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
       LD50              462Qmg/kg            rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinpgenicity:
       Neoplastic effects:
         TDLo              16 gm/kg (24 weeks)   rat                oral
   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI=87

-------
Anthraquinone
                                     CHEMICAL  NAME
    CAS Number:     84-65-1

    Chemical Name:   Anthraquinone

    Synonyms:    9,10-Dihydro-9,10-dioxoanthiacenedione


    Molecular
      Formula:    C14H8O2
    Structure:
    Chemical Properties

       Molecular Weight:   208.23

       Vapor Pressure:   1 mm at 190°C

       Boiling Point:  379.8°C at 760mm

       Density:   1.438 at 4°C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
           Fire-slight
Physical State:   Solid

Vapor Density:   7.16

Melting Point:    286°C (sublimes)

Solubility:    Insoluble (H2O)
                                             AI-88

-------
                                                                    Anthraquinone
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
             Consumption:

             Fraction of Pro-
              duction Lost:
Acute Toxicity
Non-lethal Acute Effects:
       Weak sensitizer-dermatitis
TOXICITY DATA

             Animal
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
       Neoplastic effects:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                         90 gm/kg (90 days)      tat
             TLV:
Route
                                oral
                                       AI-89

-------
Auramine
                                     CHEMICAL  NAME


    CAS Number:    492-80-8

    Chemical Name:    4,4'-CarbonimidoyIbis[N,N-dimethyl] benzenamine

    Synonyms:   4,4'-(lmidocarbonyl)bis(NJ4-dimethyl)aniline
                Auramine
                Bis(p-dimethylamine-phenyl)methyleneiinine
    Molecular
     Formula:  Ci7H2iN3
                                                Apyonin
CH
                                     NH
    Structure:
               CH,
    Chemical Properties

       Molecular Weight:     267.38

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
CH3
                                                        CHq
                                    Physical State:     Solid

                                    Vapor Density:

                                    Melting Point:   136°C

                                    Solubility:   Insoluble (H2O)
                                             AI-90

-------
                       Auramine
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal
Non-lethal Acute Effects:
Dermatitis
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Neoplastic effects:
TDLo 37 gm/kg (87 weeks rat
continuous)
2625 mg/kg (21 weeks rat
intermittent)
Carcinogenic effect:
TDLo 29 gm/kg (52 weeks mouse
_.... 	 continuous)
Mutagenicity:
Teratpgenicity: TLV:
Other Chronic Effects:






Route



oral
subcutaneous
oral



AI-91

-------
Azodrin
                                      CHEMICAL  NAME
    CAS Number:   919-44-8

    Chemical Name:    Phosphoric acid, (Z)dimethyl-l-methyl-3(methylamino)-2-oxo-l-propenyl ester
                 Phosphoric acid, dimethyl ester with (E)-hydroxyl-N-methylcrotonamide
    Synonyms:
    Molecular
      Formula:
 Dimethyl phosphate of 3-hydroxy-N-methyl-cis-crotonamide
 Monocroptophos
 O ,O-dirf^hy^O-(2-meaiylcaibarnoyl-l-rnethyl-vinyl)-pho8phate

C7H14N05P
                           O
    Structure:
                 (CH30)2 - P - O
                            CH,
     Chemical Properties

       Molecular Weight:   223.19

       Vapor Pressure:

       Boiling Point: 125°C at 760 mm

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
                                      H
                      \    H
                      C-NCH3
                       II
                      O
                                     Physical State:  Solid

                                     Vapor Density:

                                     Melting Point:

                                     Solubility:   Soluble (H2O)
     Safety Hazard:
           Fire-dangerous
           Disaster hazard-moderate-toxic fumes
                                              AI-92

-------
                                                                                 Azodrm
Annual U.S.
 Production:

Fraction of
 Dispersion:
              5 x 10° Ibs.
              Estimated as 1.0

Release Rate (million Ibs/yr):  5
                               PRODUCTION DATA
Consumption:

Fraction of Pro-
 duction Lost:
0.015
Acute Toxicity
      LDSO
                                 TOXICITY DATA

                           Dosage     '         Animal
                          2 mg/kg               rat
                          2 mg/kg               mouse
                          7 mg/kg               dog
                         11 mg/kg               rabbit
                        107 mg/kg               rabbit
                     Route
                    oral
                    oral
                    oral
                    oral
                    skin
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                              TLV:
                                        AI-93

-------
Banvel D
                                     CHEMICAL NAME
    CAS Number:    1918-00-9

    Chemical Name:   3 ,6-Dichloro-2-methoxy benzole acid

    Synonyms:  '  3,6-Dichloro-o-anisic acid
                 Dicamba
Molecular
  Formula:
                 C8H6C12O3
    Structure:   Cl
    Chemical Properties

       Molecular Weight:    221.04

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
                                                Physical State:    Solid

                                                Vapor Density:

                                                Melting Point:    114toll6°C

                                                Solubility:    Slightly soluble (H2O)
    Safety Hazard:
                                             AI-94

-------
                                                                             Banvel  D
Annual U.S.
 Production:

Fraction of
 Dispersion:
               2x10° Ibs.
               Estimated as 1.0

Release Rate (million Ibs/yr):   2
                              PRODUCTION DATA
Consumption:
Fraction of Pro-
 duction Lost:  0.015
Acute Toxicity
       LDSO
                                 TOXICITY DATA
                          Dosage
                          1040 mg/kg
                          1190mg/kg
                          2000 mg/kg
                          3000 mg/kg
                          1000 mg/kg
 Animal
 rat
 mouse
 rabbit
 guinea pig
 mammal
 Route
oral
oral
oral
oral
unknown
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                              TLV:
                                        AI-95

-------
Banvel T
                                      CHEMICAL  NAME
     CAS Number:     230749-5

     Chemical Name:   3,5,6-Trichloro-o-anisicacid

     Synonyms:    Tricamba
                  2-Methoxy-3,5,6-trichlorobenzoic acid
                  3,5,6-Tiichloro-2-methoxybenzoic acid
     Molecular
      Formula:    C8H5O3a3
     Structure:
     Chemical Properties

        Molecular Weight:   255.4

        Vapor Pressure:

        Boiling Point:

        Density:

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
Physical State:    Solid

Vapor Density:

Melting Point: 137 to 139°C

Solubility:    Slightly soluble (H2O)
     Safety Hazard:
                                               AI-96

-------
                                                                            Banvel T


                              PRODUCTION DATA
Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
       LDSO              300 mg/kg             rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                       AI-97

-------
Benzaldehyde
                                     CHEMICAL  NAME
    CAS Number:   100-52-7

    Chemical Name:    Benzaldehyde

    Synonyms:  Benzole aldehyde
               Artificial almond oil

    Molecular
      Formula:  C7H6O
Benzenecatbonal
    Structure:   f^^jTc
               *o
                            O
    Chemical Properties

       Molecular Weight:  106.12

       Vapor Pressure:  1 mm at 26.2°C

       Boiling Point:    179.0°C

       Density:  1.050 at 150C/S0C

       Octanol/Water Parti-
         tion Coefficient:  2.41

    Environmental Persistence

       BOD:    50% of theoretical after 10 days
         Physical State:  Liquid

         Vapor Density: 3.65

         Melting Point:  ,-26°C

         Solubility:   slight (H2O)
       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   File-slight
                                             AI-98

-------
                                                                         Benzaldehyde
                               PRODUCTION DATA
Annual U.S.
 Production:   3.4 x 106 Ibs. (1968)

Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr):
                                              Consumption:

                                              Fraction of Pro-
                                                duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
     LD50
                         1300 mg/kg
                         1000 mg/kg
                         5000 mg/kg
Non-lethal Acute Effects:
      Dermatitis
      Narcosis
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity: Not tested


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
guinea pig
rat
  Route
oral
oral
subcutaneous
                                              TLV:
                                        AI-99

-------
Benzamide
                                     CHEMICAL NAME
    CAS Number:     55-21-0

    Chemical Name:     Benzamide

    Synonyms:    Benzoylamide
                 Benzole add, amide

    Molecular
      Formula:    C7H7NO
                      O
                             NH
    Structure:
     Chemical Properties

       Molecular Weight:   121.14

       Vapor Pressure:

       Boiling Point:    290°C

       Density:   1.0792 at 130°C/4°C

       Octanol/Water Parti-
         tion Coefficient:   0.96

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:
Physical State:    Solid

Vapor Density:

Melting Point:    132.5°C

Solubility:   Slightly (H2O)
           Very soluble  (hot H2O)
                                            AI-100

-------
                                                                       Benzamide
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispenion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal             Route
      LDso              1160mg/kg           mouse             oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AX-101

-------
Benzene
    CAS Number:   71-43-2

    Chemical Name: Benzene

    Synonyms:  Benzol
                Phenylhydride
                Coal naptha
    Molecular
      Formula:  C6H6
                                      CHEMICAL NAME
    Structure:
     Chemical Properties

        Molecular Weight:   78.11

        Vapor Pressure:  95.9 mm at 25°C

        Boiling Point:   80.1°C at 760 mm

        Density:  0.8787 at 20°C/4"C

        Octanol/Water Parti-
         tion Coefficient:  2.28
Physical State:  Liquid

Vapor Density: 2.77

Melting Point:  5.5°C

Solubility:   Snghtlyg.79 gm/1 of H2O)
     Environmental Persistence

        BOD:    1.9% theoretical

        Atmospheric Reactivity:
                Activity toward Oj: slowly reacts with oxidizing materials
                Activity toward OH: t% = 3 days
                Photochemical Degradation: Not photoreactive; is biodegradable; found in air at 0.015-0.057 ppm


     Safety Hazard:
                                              AI-102

-------
                                                                                   Benzene
                                PRODUCTION DATA
Annual U.S.
 Production:   11,120 x 106 Ibs. (1974)

Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr):  183.6
                                                Consumption:   1,562.8 x 106 Ibs.

                                                Fraction of Pro-
                                                 duction Lost:  0.01
Acute Toxicity
     LDSO
         TOXICITY DATA

   Dosage               Animal
3800mg/kg            rat
4700 mg/kg            mouse
 468 mg/kg            mouse
1150 mg/kg            rat
2000 mg/kg            dog
 530 mg/kg            guinea pig
1400 mg/kg            frog
Non-lethal Acute Effects:
     Blood effects-TCL<,:                         human
     Aplastic anemia
     Local irritant-erythemia, burning of skin
     Narcotic action on CNS
     Euphoria
                                                                      Route
                                                                   oral
                                                                   oral
                                                                   intraperitoneal
                                                                   intraperitoneal
                                                                   oral
                                                                   intraperitoneal
                                                                   subcutaneous
                                                                    inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 10 ppm
   Carcinogenicity: TDLO 1232 mg/kg (52 weeks) mouse skin
                 Implicated in human leukemia, sarcoma
   Mutagenicity:   Positive pulmonary adenomas
                 Bone marrow cell breaks
   Teratogenicity:  No information
                                                TLV:  10 ppm
   Other Chronic Effects:
                         Estrus cycle disorder
                         Liver, kidney and lung damage
                         Hormone alteration
                         Bone marrow hyperplasia
                                         AI-103

-------
Benzenedisulfonic acid
                                    CHEMICAL  NAME
    CAS Number:    30496-93-6

    Chemical Name:     m-Benzene disulfonic acid

    Synonyms:    MBDSA
    Molecular
     Formula:    C6H6O6S2
                    SOiH
    Structure:
                           SO3H
    Chemical Properties

       Molecular Weight:   238.23

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:   Solid

Vapor Density:

Melting Point:

Solubility:   Soluble (H2O)
                                           AI-104

-------
                                                        Benzenedisulfonic acid
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Non-lethal Acute Effects:
      Irritant
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AI-105

-------
Benzenesulfonic acid
                                     CHEMICAL NAME
    CAS Number:    98-11-3

    Chemical Name:     Benzene sulfonic acid

    Synonyms:   Phenyl sulfonic acid
    Molecular
      Formula:   C6H6OsS
                     S03H
    Structure:
    Chemical Properties

       Molecular Weight:    158.12

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:    -2.25

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
Physical State:   Solid

Vapor Density:

Melting Point:   65 to 66°C (anhydrous)

Solubility:   Very soluble (H2O)
                                            AI-106

-------
                                                          Benzenesulfonic acid
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibt/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage             Animal              Route
      LDSO              2050mg/kg           rat                oral

 Non-lethal Acute Effects:
      Irritant
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                      AI-107

-------
Benzidine
                                      CHEMICAL NAME
    CAS Number:   92-87-5

    Chemical Name:    Benzidine

    Synonyms:  [l,l'-Biphenyl]-4,4'-diamine
                p-Diaminodiphenyl
                4,4'-Biphenyldiamine
    Molecular
      Formula:  C12H12N2
    Structure:   NH2 -d     }.
Chemical Properties

   Molecular Weight:  184.24

   Vapor Pressure:

   Boiling Point:   401.7°C

   Density:  1.250 at 20°C/4°C

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:     1.9 for 20 days at 20"C

   Atmospheric Reactivity:
            Reacts rapidly with RC>2
                            O3
                                    NH.
                                              4,4'-Diaminodiphenyl
                                              4,4'-Diphenylenediamine
                                                     Physical State:  Solid

                                                     Vapor Density:

                                                     Melting Point:   122 and 125°C-unstable
                                                                    128°C-stable
                                                     Solubility:   Slightly soluble (H2O)
                                         = 4 days)
                                         = 1 day)
                                 OH (tK=lday)
     Safety Hazard:
                                               AI-108

-------
                                                                                 Benzidine
                                PRODUCTION  DATA
Annual U.S.
 Production:

Fraction of
 Dispersion:
10.4 x 10° Ibs (1972)
0.01
Consumption:

Fraction of Pro-
 duction Lost:  0.015
Release Rate (million Ibs/yr):  .02
                                  TOXICITY DATA
Acute Toxicity
      LDSO
             Dosage
           309 mg/kg
           214 mg/kg
           200 mg/kg
           400 mg/kg
Non-lethal Acute Effects:
      Bone marrow depression
      Liver and kidney damage
      Blood hemolysis
      Epicardial petechial hemorrhage

Chronic Toxicity

   U.S. Occupational Standard:
 Animal
rat
mouse
dog
dog
                                                                   Route
                                                                 oral
                                                                 oral
                                                                 oial
                                                                 subcutaneous
Carcinogenicity:




   TCLo



Mutagenicity:

Teratogenicity:

Other Chronic Effects:
                         4500 mg/kg (30 days)
                         2100 mg/kg (35 weeks)
                            8 gm/kg (35 weeks)
                           75 gm/kg (3 years)
                           10 mg/m3 (56 weeks)
                           18 mg/m3 (13 years)
                                  rat
                                  rat
                                  mouse
                                  hamster
                                  rat
                                  human
                                                TLV:
                    oral
                    subcutaneous
                    subcutaneous
                    oral
                    inhalation
                    inhalation
                                         AI-109

-------
Benzil
                                     CHEMICAL  NAME
    CAS Number:    134-81-6

    Chemical Name:     Benzil

    Synonyms:   Dibenzoyl
                Diphenyl-ethanedione
                Diphenylglyoxal
    Molecular
     Formula:   C14H1002
Structure:
                           O   O
                           C-C
Chemical Properties

   Molecular Weight:   210.2

   Vapor Pressure:  1 mm at 128.4°C

   Boiling Point:    346 to 348°C (decomposes)

   Density:   1.084 at 102°C/4°C

.   Octanol/Water Parti-
     tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity-
                                                    Physical State:   Solid

                                                    Vapor Density:

                                                    Melting Point:   9S°C

                                                    Solubility:   Insoluble (H2O)
    Safety Hazard:
                                             AI-110

-------
                                                                                Benzil

                              PRODUCTION DATA
Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LD50              2710mg/kg           rat                oral
Chronic Toxichy

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-111

-------
Benzilic  acid
                                      CHEMICAL  NAME
    CAS Number:   76-93-7

    Chemical Name:    Benzilic acid

    Synonyms:   Diphenyl glycolic acid
                Diphenyl hydroxyacetic acid
                ot-Hydroxy-a-phenylbenzene acetic acid
    Molecular
      Formula:   Ci4H12O3
                           OH
                   /^\  '
    Structure:       \^J-*
                           c
                         //  \
                        O     OH
    Chemical Properties

       Molecular Weight:   228.24                      Physical State:   Solid

       Vapor Pressure:                                 Vapor Density:

       Boiling Point:    180°C (decomposes)              Melting Point:   148 to 151°C

       Density:                                       Solubility:   Slightly soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:   2.32

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
    Safety Hazard:
          Fire-slight
                                             AI-112

-------
                                                                      Benzilic acid
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
             Consumption:

             Fraction of Pro-
              duction Lost:
Acute Toxicity
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenjcity:

   Teratogenicity:

   Other Chronic Effects:
TOXICITY DATA

             Animal
             TLV:
Route
                                      AI-113

-------
Benzole acid
                                      CHEMICAL  NAME
    CAS Number:  65-85-0

    Chemical Name:   Benzole Acid

    Synonyms:  Phenyl foimic acid
                Benzene catboxylic acid
                Carboxybenzene
    Molecular
      Formula:  C7H6O2
     Chemical Properties

        Molecular Weight:  122.12

        Vapor Pressure: 1 mm at 96.0°C

        Boiling Point:  249°C

        Density:  1.2659 15°C/4°C

        Octanol/Water Parti-
         tion Coefficient:  2.00

     Environmental Persistence

        BOD:    46% of theoretical after 10 days

        Atmospheric Reactivity:  Reacts with oxidizing materials
Physical State:  Solid

Vapor Density: 4.21

Melting Point:  122.4°C

Solubility:  Slightly (H2O)
     Safety Hazard:  Fire-sli
                                              AI-114

-------
                                                                           Benzole acid
                               PRODUCTION DATA

Annual U.S.
 Production:   79 x 106 Ibs. (1974)                 Consumption:  70 x 10* Ibs. (1975)
                                                            (excludes phenol production)
Fraction of                                                   ca. 90 x.106 Ibs.
 Dispersion:    0.01                                           (phenol production)
           .  	  . .                        Fraction of Pro-
Release Rate (million Ibs/yr):                         Auction Lost:  0.015
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
     LDSO               3040mg/kg             rat                 oral
                         2370mg/kg             mouse              oral
                         1460 mg/kg             mouse              intraperitoneal

Non-lethal Acute Effects:
     Skin effects-TDLo       6 mg/kg             human              skin
     Gastrointestinal effects
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                        AI-115

-------
Benzoin
                                      CHEMICAL NAME
    CAS Number:   119-53-9

    Chemical Name:    Benzoin

    Synonyms:  Phenyl a-hydroxybenzylketone
                Phenylbenzoylcarbinol
    Molecular
      Formula:
                                                 Benzoylphenylcarbinol
                                                 2-Hy droxy-1,2-diphenylethanone
Structure:
                            OH    O
                             !     "
                            CH - C
     Chemical Properties   (dl mixture)

        Molecular Weight:      212.24

        Vapor Pressure:  1 mm at 135.6°C

        Boiling Point:   344°C at 768 mm

        Density:   1.310 at 20°C/4°C

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOO:

        Atmospheric Reactivity:
                                                 Physical State:  Solid

                                                 Vapor Density:

                                                 Melting Point:  137°C

                                                 Solubility:    Slightly (hot H2O)
     Safety Hazard:
           Fire-slight
                                               AI-116

-------
                                                                             Benzoin
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
             Consumption:

             Fraction of Pro-
              duction Lost:
Acute Toxicity
TOXICITY DATA

             Animal
Route
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
             TLV:
                                      AI-117

-------
Benzonitrile
                                      CHEMICAL  NAME
    CAS Number:   100-47-0

    Chemical Name:    Benzonitrile

    Synonyms:   Phenyl cyanide
                Benzoic acid, nitrile

    Molecular
      Formula:   C7H5N
    Structure:
                            C  =  N
     Chemical Properties

       Molecular Weight:   103.13

       Vapor Pressure:  1 mm at 28.2°C

       Boiling Point:   190.7°C

       Density:   1.246at20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:   1.56

     Environmental Persistence

       BOD:     40% of theoretical

       Atmospheric Reactivity:
     Safety Hazard:
Physical State:   Liquid

Vapor Density:

Melting Point:   -13.1°C

Solubility:   Slightly (hot H2O)
                                             AI-118

-------
                                                                        Benzonitrile
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duetioh Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSO               1200mg/kg           tat                skin
      LDLo               720mg/kg           tat                otal
                          180 mg/kg           mouse              subcutaneous
                          950 ppm (8 houts)     tat                inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:     Not tested


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-119

-------
Benzophenone
                                     CHEMICAL  NAME
    CAS Number:    119-61-9

    Chemical Name:     Benzophenone

    Synonyms:    Phenyl ketone
                 Diphenyl ketone
                 Diphenyl methanone
    Molecular
      Formula:    C13HioO
 Benzoylbenzene
                            O
    Structure:
     Chemical Properties

       Molecular Weight:   182.21

       Vapor Pressure:  1 mm at 108.2°C

       Boiling Point:    305.9°C at 760 mm

       Density:  a form 1.0976 at 50°C/50°C

       Octanol/Water Parti-
         tion Coefficient:
Physical State:   Solid

Vapor Density:

Melting Point:   47.5°C(a)

Solubility:    Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
           Fire-slight
                                             AI-120

-------
                                                                   Benzophenone
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                 .                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:    Under test


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AI-121

-------
Benzoquinone
                                     CHEMICAL  NAME
    CAS Number:    106-51-4

    Chemical Name:     p-Benzoquinone

    Synonyms:   Quinone
                Chinone

    Molecular
      Formula:   C6H4O2
    Structure:
     Chemical Properties

       Molecular Weight:   108.09  '

       Vapor Pressure:

       Boiling Point:    Sublimes

       Density:  1.318 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
 1,4-Benzoquinone
 Paiaquinorie
Physical State:  Solid

Vapor Density:

Melting Point:   115.7°C

Solubility:    Soluble (H2O)
     Safety Hazard:
           Disaster hazafd-dangerous-toxic fumes
                                             \I-122

-------
                                                                       Benzoquinone
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
      LDSO
      LC
         Lo
 130 mg/kg
8500 mg/kg
  25 mg/kg
 320 mg/m
Animal
rat
mouse
rat
mouse
 Non-lethal Acute Effects:
      Irritation of skin and mucous membranes
      Necrosis, if in eyes
      Kidney damage
      Dermatitis
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinooenicity:
      TDLo
   Mutapnicity:

   Teratogenicity:

   Other Chronic Effects:
2000 mg/kg (28 weeks)    mouse
 Route
oral
intiaperitoneal
intravenous
inhalation
                   skin
                      TLV:   0.1 mg/m3
                                        AI-123

-------
Benzotrichloride
                                     CHEMICAL NAME
    CAS Number:   98-07-7


    Chemical Name:    a^.a-Trichlorotoluene


    Synonyms:  Phenylchloroform
    Molecular
      Formula:  C7HSC13
    Structure:
a
 i
c -  a
 i
a
    Chemical Properties


       Molecular Weight:   195.48

       Vapor Pressure:  1 mm at 45.8°C


       Boiling Point:   220.6°C at 760 mm

       Density:   1.38 at 15.5°C/15.5°C

       Octanol/Water Parti-
        tion Coefficient:


    Environmental Persistence

       BOD:


       Atmospheric Reactivity:
    Safety Hazard:
                       Physical State:  Liquid

                       Vapor Density:  6.77


                       Melting Point:   -4.75°C

                       Solubility:   Insoluble (H2O)
                                            AI-124

-------
                                                                 Benzotrichloride
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
Acute Toxicity
     LDLo
     LCLo
        TOXICITY DATA

  Dosage               Animal
2150 mg/kg            frog
 125 ppm (4 hours)      rat
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:   Not tested


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
  Route
unreported
inhalation
                                       AI-125

-------
Benzoyl  chloride
                                     CHEMICAL NAME
    CAS Number:   98-884

    Chemical Name:    Benzoyl chloride

    Synonyms:   Benzene carbonyl chloride
                a-Chlorobenzaldehyde

    Molecular
      Formula:   C7H5C1O
    Structure:
                             O
                             II
                             C - Cl
     Chemical Properties

       Molecular Weight:   140.57

       Vapor Pressure:  1 mm at 32.19C

       Boiling Point:    197.2°C at 760 mm

       Density:   1.2120 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:     40% of theoretical

       Atmospheric Reactivity:
Physical State:   Liquid

Vapor Density:   4.88

Melting Point:   -0.5°C

Solubility:   Slightly (decomposes) (H2O)
     Safety Hazard:
           Disaster hazard—dangerous—fumes of phosgene
                                             AI-126

-------
                                                                  Benzoyl  chloride
Annual U.S.
 Production:

Fraction of
 Dispersion:
                              PRODUCTION DATA
Estimated as 16.8 x 10 Ibs. (1975)   Consumption:
                               Fraction of Pro-
                                 duction Lost:
                0.015
Release Rate (million Ibs/yr):
                                TOXICITY DATA
Acute Toxicity
      LDso

      TCLo
            Dosage
           2460 mg/kg
            790mg/kg
             16ppm
 Non-lethal Acute Effects:
      Irritant to skin, eyes, and mucous membranes
      Lachrymatory
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:    Not tested


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
rabbit
human
                                TLV:
  Route
oral
skin
inhalation
                                       AI-127

-------
Benzyl alcohol
                                      CHEMICAL  NAME
    CAS Number:   100-51-6

    Chemical Name: Benzyl alcohol

    Synonyms:      Hydroxytoluene
                   Phenylcaibinol
                   a-Hydioxytoluene
    Molecular
      Formula:   C7H8O
Benzenemethanol
    Structure:        /~CH2OH
     Chemical Properties

       Molecular Weight:  108.13

       Vapor Pressure:  1 mm at 58.0°C

       Boiling Point:   205.35°Cat760mm
        Density:  1.0419 at 20°C/4°C

        Octanol/Water Parti-
         tion Coefficient:  1.10
        Physical State:  Solid

        Vapor Density: 3.72

        Melting Point:  -15.3°C

        Solubility:  Soluble (H2O)
     Environmental Persistence

       BOD:    63% of theoretical

       Atmospheric. Reactivity:  Reacts with oxidizing materials
     Safety Hazard:  Fire-slight
                                              AI-128

-------
                                                                           Benzyl alcohol
Annual U.S.
  Production:   10.4 xio6 ibs. (1972)

Fraction of
  Dispersion: 0.01

Release Rate (million Ibs/yr):
       PRODUCTION DATA


                       Consumption:  11.7 x 106 Ibs. (1974)

                       Fraction of Pro-
                        duction Lost: 0.015
                                   TOXICITY DATA
Acute Toxicity
      LD50
      LD
        Lo
      LC5o
   Dosage
1230 mg/kg
  64 mg/kg
1580 mg/kg
 480 mg/kg
1940 mg/kg
 100 mg/kg
 400 mg/kg
  50 mg/kg
   9 mg/kg
 400 mg/kg
1000 pm (8 hours)
 Animal
rat
rat
mouse
mouse
rabbit
wild bird
rat
dog
dog
guinea pig
Non-lethal Acute Effects:
      Irritant-skin, mucous membranes
      Headache, vertigo, nausea, vomiting, and diarrhea
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                       TLV:
   Route
oral
intravenous
oral
intravenous
oral
oral
intraperitoneal
intravenous
parenteral
intraperitoneal
                                          AI-129

-------
Benzylamine
                                     CHEMICAL  NAME
    CAS Number:      100-46-9

    Chemical Name:    Benzenemethanamine

    Synonyms:  Aminotoluene
    Molecular
      Formula:  C7H9N
                         CH2NH2
    Structure:
    Chemical Properties

       Molecular Weight:   107.2

       Vapor Pressure: 1 mm at 29°C

       Boiling Point:   184.5°C

       Density:    0.983 at 19°C/4°C

       Octanol/Water Parti-
        tion Coefficient:   1.14

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Disaster hazard-moderate-toxic fumes
Physical State:    Liquid

Vapor Density:

Melting Point:

Solubility:   Very soluble (H2O)
                                            AI-130

-------
                                                                     Benzylamine
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal             Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity: Not tested


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AI-131

-------
Benzylbenzene
                                     CHEMICAL  NAME
    CAS Number:     101-81-5

    Chemical Name:   Diphenyl methane

    Synonyms:    Benzylbenzene
                 Ditan
    Molecular
      Formula:
                    ,-CH,
    Structure:
     Chemical Properties

       Molecular Weight:    168.23                     Physical State:   Solid

       Vapor Pressure:   lmmat76.0°C                Vapor Density:   5.79

       Boiling Point:     264.7°C at 760 mm             Melting Point:    26.5°C

       Density:   1.0056 at 20°C/4°C                   Solubility:    Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
     Safety Hazard:
            Fire-slight
                                             AI-132

-------
                                                                   Benzylbenzene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                    Consumption:

                    Fraction of Pro-
                      duction Lost:
                               TOXICITY DATA
Acute Toxicity
  Dosage
5000 mg/kg
Animal
rat
  Route
oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:   Not tested


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                    TLV:
                                     AI-133

-------
ienzyt  benzoate
                                     CHEMICAL  NAME
    CAS Number:     120-51-4

    Chemical Name:     Benzole acid, benzyl ester

    Synonyms:    Benzyl benzoate
                 Benzyl benzene carboxylate

    Molecular
     Formula:
    Structure:
    Chemical Properties

       Molecular Weight:   212.25

       Vapor Pressure:  <10 mm at 25°C

       Boiling Point:    323 to 324°C at 760 mm

       Density:    1.1121 at 25°C/4°C

       Octanol/Water Parti-
        tion Coefficient:   3.97
Physical State:   Liquid

Vapor Density:   7.3

Melting Point:    21°C

Solubility:   Insoluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
    Safety Hazard:
           Fire-slight
                                             AI-134

-------
                                                                 Benzyl benzoate
                              PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
      LDSo              1700 mg/kg           rat                 oral
                         1400 mg/kg           mouse              oral
                         2240 mg/kg           cat                 oral
                         1800 mg/kg           rabbit              oral
                         1000 mg/kg           guinea pig           oral
Chronic Toxieity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-135

-------
Benzyl chloride
                                      CHEMICAL  NAME
    CAS Number:  100-44-7

    Chemical Name:   a-Chlorotoluene

    Synonyms:  a^Tolylchloride


    Molecular
      Formula:   C7H7C1
    Structure:   
-------
                                                                        Benzyl chloride
                               PRODUCTION DATA
Annual U.S.
 Production:   80.4 x 106 Ibs. (1972)

Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr):
                      Consumption:  90 x _10_6 Ibs. (1974)^

                      Fraction of Pro-
                        duction Lost: 0.015
                                  TOXICITY DATA
Acute Toxicity
     LDSO
1231 mg/kg
1000 mg/kg
1624 mg/kg
 Animal
rat
rat
mouse
Non-lethal Acute Effects:
      Unspecified effects:
        TCLO              16 ppm              human
      Irritant-intensely to eyes, skin, and mucous membranes
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
      Neoplastic effects:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                         2100 mg/kg (51 weeks)   rat
                      TLV:
CNS depression
  Route
oral
subcutaneous
oral
                                          inhalation
                                          subcutaneous
                                         AI-137

-------
Benzyldichloride
                                     CHEMICAL NAME
    CAS Number:    98-87-3

    Chemical Name:     a^-Dichlorotoluene

    Synonyms:    Benzyl dichloiide
                 Benzal chloride
                 Benzylidine chloride
    Molecular
      Formula:    C7H6C12
    Structure:
                a -  c - a
                      i
                      H
     Chemical Properties

       Molecular Weight:   161.03

       Vapor Pressure:   <10 mm at 25°C

       Boiling Point:  205.2°C at 760mm

       Density:   1.295 at 16°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
 (DichloromethyO-benzene
Physical State:   Liquid

Vapor Density:

Melting Point:   -16.1°C

Solubility:   Insoluble (H2O)
                                            AI-138

-------
                                                                  Benzyldichloride
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                    Consumption:

                    Fraction of Pro-
                     duction Lost:
                                TOXICITY DATA
Acute Toxicity
       LDSO

       LCSO
 Dosage
3249mg/kg
 467 mg/kg
 200 mg/nr
Animal
 rat
 mouse
 mouse
 Route
oral
oral
inhalation
  Non-lethal Acute Effects:
       Irritant-strong lachrymator
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Not tested


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
       CNS despression
                    TLV:
                                        AI-139

-------
Bis  (chloromethyl) ether
                                     CHEMICAL NAME
    CAS Number:    542-88-1

    Chemical Name:     Oxybis(chloromethane)

    Synonyms:   Dichloromethyl ether
                Dichlorinated methyloxide
                BCME
    Molecular
      Formula:   C2H4C12O
    Structure:
                 C1CH, -  O - CH,C1
    Chemical Properties

       Molecular Weight:    114.96

       Vapor Pressure:

       Boiling Point:    104°C at 760 mm

       Density:   1.328 at 15°C/4°C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
 l.l'-Dichlorodimethyl ether
Physical State:   Liquid (volatile)

Vapor Density:   4.0

Melting Point:    -41.5°C

Solubility:    Decomposes (H2O)
                                             AI-140

-------
                                                       Bis  (chloromethyl)  ether
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
       LDSo              210 mg/kg             rat                oral
                         280mg/kg             rabbit              skin
       TDn>              315 mg/kg (245 days,     rat                subcutaneous
                                  intermittent)
                          11 gm/kg (47 weeks,     mouse             skin
                                  intermittent)
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:     Carcinogen, produces tumors


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                       AI-141

-------
Bisphenol  A
                                      CHEMICAL  NAME
    CAS Number:  80-05-7

    Chemical Name:  4,4'-Isopropylidenediphenol

    Synonyms:   Bisphenol A
                2,2-Bis (4-hydroxyphenyl) propane
                4,4' -Isopropylidenediphenol
    Molecular
      Formula:   CiSH16O2



                               "V
                                       OH
                  -  \    "  \=/
    Structure:           C
                      s        i   \

                               ^^OH
     Chemical Properties

       Molecular Weight:  228.29                       Physical State: Solid

       Vapor Pressure:  1 mm at 193°C                   Vapor Density:

       Boiling Point:   250to252°C                     Melting Point: 153°C

       Density:                                       Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
                                             AI-142

-------
                                                                           Bisphenol  A
                               PRODUCTION DATA

Annual U.S.
 Production:   370.4 x 106 Ibs. (1974)              Consumption:   370.4 x 106 Ibs.

Fraction of                                     Fraction of Pro-
 Dispersion: o.Ol                                 duction Lost:  0.015

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
                        150 mg/kg             rat                 intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA: 0.5 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:
                                              (odorless)
   Other Chronic Effects:
                                        AI-143

-------
Bromacil
                                    CHEMICAL  NAME
    CAS Number:    314-42-1

    Chemical Name:   5-Brom(^-secbmyM^eaiyluracil
    Synonyms:    Boiea
    Molecular
     Formula:    C9H13BiN2O2
    Structure:
                             CH3
Chemical Properties

   Molecular Weight:   247.12

   Vapor Pressure:

   Boiling Point:   Sublimes _

   Density:

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
    Safety Hazard:
                                                   Physical State:    Solid

                                                   Vapor Density:

                                                   Melting Point:    158 to 159°C

                                                   Solubility:    815 ppm at 25°C
                                            AI-144

-------
                                                                             Bromacil
Annual U.S.
 Production:    8 x 106 Ibs.

Fraction of
 Dispersion:    Estimated as 1.0

Release Rate (million Ibs/yr):  8
                              PRODUCTION DATA
                    Consumption:
                     Fraction of Pro-
                      duction Lost:   0.015
                                 TOXICITY DATA
Acute Toxieity
      LDSO
3400 mg/kg
3750 mg/kg
Chronic Toxieity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
mouse
                    TLV:
 Route
oral
oral
                                       AI-145

-------
Bromobenzene
                                     CHEMICAL  NAME
    CAS Number:    108-86-1

    Chemical Name:     Bromobenzene

    Synonyms:   Phenylbromide
    Molecular
      Formula:    C6H5Bt
                  Br

    Structure:
     Chemical Properties

       Molecular Weight:    157.02                     Physical State:   Liquid

       Vapor Pressure:  48 mm at 25°C                 Vapor Density:   5.41

       Boiling Point:  156.2°C at 760 mm                Melting Point:    -30.5°C

       Density:   1.4950 at 20°C/4°C                  Solubility:    Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:    2.99

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
     Safety Hazard:
           Fire-moderate
                                             AI-146

-------
                                                                    Bromobenzene
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITYDATA

Acute Toxicity              Dosage               Animal              Route


 Non-lethal Acute Effects:                                    :
      At high concentrations, may cause paralysis and skin irritation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:    Not tested


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-147

-------
Bromonaphthalene
                                    CHEMICAL  NAME
    CAS Number:  580-13-2

    Chemical Name:   2-Bromonaphthalene

    Synonyms:


    Molecular
     Formula:  Ci0H7Br
    Structure:
    Chemical Properties

       Molecular Weight:     207.08

       Vapor Pressure: 1 mm at 84.2°C

       Boiling Point:  281 to 282°C at 760 mm

       Density:     1.605 at 0"C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Physical State:     Solid

Vapor Density:

Melting Point:  59°C

Solubility:  Insoluble (H2O)
    Safety Hazard:
                                           AI-148

-------
                                                            Bromonaphthalene
                            PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                              TOXICITY DATA

Acute Toxicity              Dosage   ,          Animal             Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogen icity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AI-149

-------
1,  3-Butadiene
                                      CHEMICAL  NAME
     CAS Number:   106-99-0

     Chemical Name:    1,3-Butadiene

     Synonyms:  Erythiene
                Biethylene
                Bivinyl
     Molecular
      Formula:  C.tH6
    Structure:  CH2 = CH  - CH = CH2
     Chemical Properties

        Molecular Weight:   54.09

        Vapor Pressure:  1690 mm at 25°C

        Boiling Point:   -4.5°C

        Density:  0.621 at 20°C/4°C

        Octanol/Water Parti-
         tion Coefficient:
Butadiene
a-0-Butadiene
Divinyl
Pyrrolylene
Vinylethylene
            Physical State:  Gas

            Vapor Density: 1-87

            Melting Point:  -109.91°C

            Solubility: Insoluble (H2O)
     Environmental Persistence

        BOD:

        Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fire-dangerous
                   Explosion-moderate-forms explosive peroxides with air
                   Disaster hazard—moderate-toxic fumes
                                              AI-150

-------
                                                                        1, 3-Butadiene
                               PRODUCTION DATA

Annual U.S.
 Production:   3682.1 x 10* Ibs. (1974)              Consumption:  4208 x 106 Ibs.

Fraction of                                      Fraction of Pro-.
 .Dispersion:    0.01                               duction Lost: 0.01S

Release Rate (million Ibs/yr): S6.9 (1972)
                                 TOXICITYDATA

Acute Toxicity               Dosage               Animal               Route
     LDLo         250,000 ppm (25 minutes)     human              inhalation

Non-lethal Acute Effects:
     Irritant to eyes and mucous membranes
     Unconsciousness due to inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA: 1000 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV: 1000 ppm (skin)

   Other Chronic Effects:
        Slight irritation of eyes, upper respiratory tract:  8000 ppm (8 hours)
                                         AI-151

-------
Butane
                                      CHEMICAL  NAME
    CAS Number:    106-97-8

    Chemical Name:  Butane

    Synonyms:    Methylethylmethane
                 Butylhydride
                 Diethyl
    Molecular
      Formula:     C4H10
 n-Butane
    Structure:    CH3CH2CH2CH3
    Chemical Properties

       Molecular Weight:   58.13

       Vapor Pressure:   ca. 2
       Boiling Point:     -0.5°C

       Density:   0.6012 at 0°C/4°

       Octanol/Water Parti-
         tion Coefficient:
Physical State:   Gas

Vapor Density:   2.046

Melting Point:   -138.35°C

Solubility:    85.98 gm/1 of H2O
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
    Safety Hazard:
           Fire-dangerous
           Explosion-moderate
           Disaster hazard-moderate-toxic fumes
                                              AI-152

-------
                                                                                 Butane
                               PRODUCTION DATA
Annual U.S.
 Production:    2331.1 x 106 Ibs.
Fraction of
 Dispersion:
0'
Consumption:    2331.1 x 106 Ibs.

Fraction of Pro-
 duction Lost:   0.01
Release Rate (million Ibs/yr):   23.3
Acute Toxicity
       LDSO

Non-lethal Acute Effects:
       Drowsiness
       Narcotic
       Simple asphyxiant
                                 TOXICITY DATA
           658 mg/m
 Animal
 rat
 Route
inhalation
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 500 ppm



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                               TLV:
                                        AI-153

-------
1-Butene


                                     CHEMICAL  NAME


    CAS Number:    106-98-9

    Chemical Name:     1-Butene

    Synonyms:   1-Butylene
                o-Butylene
                Ethylethylene
    Molecular
     Formula:   C4H8





    Structure:   cH3 - CH2 - CH = CH2
    Chemical Properties

       Molecular Weight:   56.12                       Physical State:  Gas

       Vapor Pressure:  3480at21°C                    Vapor Density:  1.93

       Boiling Point:   -6.3°C at 760 mm                Melting Point:   -185.35°C

       Density:   0.5951 at 20°C/4°C                    Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-dangerous
          Explosion—moderate
                                             AI-154

-------
                                                                            1-Butene

                              PRODUCTION DATA
Annual U.S.
 Production:    2478 x 106 Ibs. (total butenes)       Consumption:   3960xl06Ibs.
Fraction of                                    Fraction of Pro-
 Dispersion:                                  .   duction Lost:
Release Rate (million Ibs/yr):

                                TOXICITY DATA
Acute Toxicity              Dosage               Animal              Route
 Non-lethal Acute Effects:
      Asphyxiant
Chronic Toxicity
   U.S. Occupational Standard:

   Carcinogenicity:

   Mutagenicity:
   Teratogenicity:                               TLV:
   Other Chronic Effects:
                                       AI-155

-------
2-Butene  (cis and trans)
                                      CHEMICAL  NAME
    CAS Number:    107-01-7

    Chemical Name:    2-Butene

    Synonyms:  2-Butene (cis and trans)
               Dimethylethylene
               Pseudobutylene
    Molecular
      Formula:  C4H8
                                                                      CH
    Structure:
               H,C
C  =  C
                       Cis
           CH,
H,C
      C  =  C
                                        Trans
    Chemical Properties

       Molecular Weight:  56.12

       Vapor Pressure:  1410 mm at 21°C (cis)
                      1592 mm at 21°C (trans)
       Boiling Point:    3.7°C at 760 mm (cis)
                      0.88°C at 760 mm (trans)
       Density:  0.6213 at 20°C/4°C (cis)
                0.6042 at 20°C/4°C (trans)
       Octanol/Water Parti-
         tion Coefficient:
                                Physical State:  Gas

                                Vap or Density:  l .9 (cis and trans)

                                Melting Point:  -138.91°C (cis)
                                              -105.55°C (trans)
                                Solubility:   Insoluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-dangerous
                                             AI-156

-------
                                                       2-Butene (cis and trans)
                              PRODUCTION DATA

Annual U.S.
 Production:    2,478 x 106 Ibs. (totalbutenes)       Consumption:   3,600 x 106 Ibs.
Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                   Fraction of Pro-
                    duction Lost: 0.015
Acute Toxicity
Non-lethal Acute Effects:
      Simple asphyxiant
      TOXICITY DATA

Dosage               Animal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Route
                   TLV:
                                       AI-157

-------
2-Butoxyethanol
                                     CHEMICAL NAME
CAS Number:   111-76-2

Chemical Name: 2-Butoxyethanol

           N-butoxyethanol
„       .
bynonyms:
                                             Butylglycol            3-Oxa-l-heptanol
               2-Butoxy-l-ethanol               Butyl oxitol            Butyl cellosolve
               Ethylene glycol, monobutyl ether   o-Butyl ethylene glycol   Glycol, n-butyl ether
    Molecular
      Formula:  C6H14O2
    Structure:   OH - CH2 - CH2 - O CH2 - CH2 - CH2 - CH3
    Chemical Properties

       Molecular Weight:  118.18

       Vapor Pressure:  0.88 mm at 2S°C

       Boiling Point:   171.2°C

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-moderate
                                               Physical State:  Liquid

                                               Vapor Density:  4.07

                                               Melting Point:

                                               Solubility:  45gm/lofH2O
                                            AI-158

-------
                                                                      2-Butoxyethanol
                               PRODUCTION DATA
Annual U.S.
 Production:   133.3 x 106 Ibs.

Fraction of
 Dispersion:    0.97

Release Rate (million Ibs/yr): 122.6
                      Consumption:  124.3 x 106 Ibs.

                      Fraction of Pro-
                        duction Lost: 0.0IS
                                  TOXICITY DATA
Acute Toxicity
     LDSO
      LCso
      LCLo

      Irritant Effects:
         TDLo
  Dosage
1480 mg/kg
 550 mg/kg
 340 mg/kg
1230 mg/kg
 536 mg/kg
1130 mg/kg
 320 mg/kg
 560 mg/kg
 280 mg/kg
1200 mg/kg
 230 mg/kg
700 ppm (7 hours)
 500 ppm (4 hours)
 195 ppm (8 hours)
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
rat
rat
mouse
mouse
mouse
rabbit
rabbit
rabbit
guinea pig
guinea pig
mouse
rat
human
  Route
oral
intraperitoneal
intravenous
oral
intraperitoneal
intravenous
oral
skin
intravenous
oral
skin
inhalation
inhalation
inhalation
                      TLV:
                                         AI-159

-------
n -Butyl acetate
                                      CHEMICAL  NAME
    CAS Number:  123-86^

    Chemical Name:   Acetic acid, butyl ester

    Synonyms:   Butyl acetate
                Butyl ethanoate
                Butyl ester of acetic acid
    Molecular
      Formula:   C6H12O2
                           o
    Structure:  CH3 -  C
                           O - (CH2)3 -
     Chemical Properties

       Molecular Weight:  116.16

       Vapor Pressure:    15 mm at 25°C

       Boiling Point:  125°C

       Density:  0.882 at 20°/20°C

       Octanol/Water Parti-
         tion Coefficient:
Physical State:  Liquid

Vapor Density:

Melting Point:  -77.9

Solubility:  6.29gm/lof H2O
     Environmental Persistence

       BOD:    1.83 for 20 days at 20°C

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard: Fire-modeiate
                  Explosion—moderate
                                              AI-160

-------
                                                                        n-Butyl  acetate
                               PRODUCTION DATA
Annual U.S.
 Production:   77.2 x 106 Ibs. (1974)

Fraction of
 Dispersion:    1.0

Release Rate (million Ibs/yr): 97.1 (1972)
                       Consumption:  77.2 x 106 Ibs.

                       Fraction of Pro-
                        duction Lost: 0.015
                                  TOXICITY DATA
Acute Toxicity
     LDSO
   Dosage
1230 mg/kg
1500 mg/kg
3200 mg/kg
4700 mg/kg
Non-lethal Acute Effects:
      Irritant effects-TCLo   200 ppm
      Eyes and respiratory tract
 Animal
mouse
rat
rabbit
guinea pig
                      human
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA: 150 ppm



   Carcinogenicity: Not tested


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:    Narcosis
                       TLV:
   Route
intraperitoneal
intraperitoneal
oral
oral
                   inhalation
                                         AI-161

-------
sec-Butyl  acetate
                                     CHEMICAL  NAME
    CAS Number:     105-46-4

    Chemical Name:   Acetic acid, secondary butyl ester
    Synonyms:
    Molecular  .
     Formula:
sec-Butyl acetate
2-Butonal acetate
C6H,202
                      O
    Structure:   CH3 - C - O - C  - CH2CH3
                                CHo
    Chemical Properties

       Molecular Weight:     116.16

       Vapor Pressure:

       Boiling Point:    112.2°C at 760mm
       Density: 0.8758 at 16°C/4°C

       Octanol/Water Parti-
        tion Coefficient:
                                  Physical State:     Liquid

                                  Vapor Density: 4.0

                                  Melting Point:

                                  Solubility:  Insoluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-dangerous
          Explosion-moderate
                                            AI-162

-------
                                                                 sec-Butyl acetate
                              PRODUCTION DATA

Annual U.S.
 Production:                 ,                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:  (aii) TWA 200 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
      Minor allergen and irritant
      Moderately toxic if inhaled or ingested
                                      AI-163

-------
tert-Butyl acetate
                                     CHEMICAL  NAME
     CAS Number:   540-88-5

     Chemical Name:    Acetic acid, 1,1-dimethylethyl ester

     Synonyms:   tert-Butyl acetate
                Acetic acid, tert-butyl ester
     Molecular
      Formula:
                                 CH3
     Structure:   CH3  - C  - O - C - CH3
                       O
     Chemical Properties

        Molecular Weight:     116.16

        Vapor Pressure:

        Boiling Point:   97 to 98°C at 760 mm

        Density:  0.8665 at 20°C/4°C

        Octanot/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOO:

        Atmospheric Reactivity:
     Safety Hazard:
Physical State:  Liquid

Vapor Density:

Melting Point:

Solubility:   Slightly (H2O)
                                             AI-164

-------
                                                               tert-Butyl  acetate
                              PRODUCTION DATA

Annual U.S.                                         .
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 200 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
      Minor allergen and irritant
      Moderately toxic if inhaled or ingested
                                      AI-165

-------
n-Butyl  acrylate
                                     CHEMICAL  NAME
    CAS Number:   141-32-2

    Chemical Name:    Acrylic acid, butyl ester

    Synonyms:   n-Butyl acrylate
                2-Propenoic acid, butyl ester
    Molecular
      Formula:   C7H12O2
                              O
    Structure:    CH2 = CH - C  - O(CH2)3CH3
    Chemical Properties

       Molecular Weight:  128.17

       Vapor Pressure:  5.63 mm at 25°C

       Boiling Point:    146 to 148°C at 760 mm

       Density:    0.8898 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:
Physical State:  Liquid

Vapor Density:  4.42   •

Melting Point:  -64.6°C

Solubility:  Insoluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-moderate
                                             AI-166

-------
                                                                   n-Butyl  acrylate
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
      LDjo              3730 mg/kg            rat                 oral
                        2000 mg/kg            rabbit              skin
                        1000 ppm (4 hours)     rat                 inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:    Not tested


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-167

-------
it-Butyl alcohol
                                      CHEMICAL  NAME
CAS Number:   71-36-3

Chemical Name:    Butyl alcohol
-           Butanol
Synonyms:
                1-Butanol
                Butyl alcohol
Butyl hydroxide
r-Hydroxybutane
Methyiolpropane
                                                                      Propylcarbinol
                                                                      n-Propylcarbinol
    Molecular
      Formula:   C3H10O
    Structure:    CH3 - CH2 - CH2 - CH2 OH
    Chemical Properties

       Molecular Weight:  74.12

       Vapor Pressure:  7.69 mm at 25°C

       Boiling Point:   117 to 118°Cat760mm

       Density:  0.80978 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:  1.00
      Physical State:  Liquid

      Vapor Density: 2.55

      Melting Point:  -89.0°C

      Solubility:  Soluble (84.92 gm/1 H2O)
     Environmental Persistence

       BOD:    2.4 for 20 days at 20°C

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:  Fire-dangerous
                   Explosion-moderate
                   Disaster hazaid-moderate-toxic fumes
                                             AI-168

-------
                                                                          n-Butyl alcohol
                                PRODUCTION DATA
Annual U.S.
 Production:   557.6 x 106 Ibs.

Fraction of
 Dispersion:   0.23

Release Rate (million Ibs/yr):    144.6
                       Consumption:  350 xlO6 Ibs. (1975)

                       Fraction of Pro-
                        duction Lost:  °-015
                                  TOXICITY DATA
Acute Toxicity
     LDSO
     LDLo
   Dosage
 790 mg/kg
 970 mg/kg
4250 mg/kg
 Animal
rat
rat
rabbit
  Route
oral
intraperitoneal
oral
Non-lethal Acute Effects:
      Pulmonary effects-TCLo 25 ppm              human
      Irritant-eyes, cornea! inflammation, headache, dizziness
      Slight irritant-nose and throat
      Dermatis-fingernails and finger
      Keratitis-reported
                                     inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA: 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
        Eye irritation:         50 ppm
        Mild irritation:        25 ppm
        Headaches:           50 ppm
                       TLV:  100 ppm
                                         AI-169

-------
sec-Butyl  alcohol
                                     CHEMICAL NAME
    CAS Number:   78-92-2

    Chemical Name:   sec-Butyl alcohol

    Synonyms:   Butan-2-ol
                Ethyl methyl caibinol
                2-Butyl alcohol
    Molecular
      Formula:   C4H10O
                CH, - CH, - CH - CH,
    Structure:               ,
                            OH
Butylene hydrate
2-Butanol
Methyl ethyl caibinol
s-Butanol
2-Hydroxy butane
     Chemical Properties

       Molecular Weight:  74.12

       Vapor Pressure:  17.5 mm at 25°C

       Boiling Point:    99.5

       Density:  0.808 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:
           Physical State:  Liquid

           Vapor Density: 2.55

           Melting Point:  -114.7°C

           Solubility:   101gm/lofH2O
     Environmental Persistence

       BOD:    2.0 for 50 days at 20°C

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fire-dangerous
                                             AI-170

-------
                                                                   sec-Butyl alcohol
                              PRODUCTION DATA

Annual U.S.
 Production:   417 x ip'jbs.                     Consumption:  417_x_l06_lbs.

Fraction of                                    Fraction of Pro-
 Dispersion:   0.05                              duction Lost: 0.01S

Release Rate (million Ibs/yr): 27.1
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LD5o               771 mg/kg            mouse              intraperitoneal
     LDLo              6000 mg/kg            rabbit              oral
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA: 150 ppm



   Carcinogenicjty: Not tested


   Mutagenicity:

   Teratogenicity:                               TLV: 150 ppm

   Other Chronic Effects:
                                       AI-171

-------
tert-Butyl alcohol
    CAS Number:   75-65-0

    Chemical Name: tert-Butyl alcohol

    Synonyms:  2-Methyl-2 propanol
               1,1-Dimethyl ethanol

    Molecular
      Formula:  C£H10O



                    CH,
    Structure:   H3C - C - OH
                    CH3



    Chemical Properties

       Molecular Weight:   74.12

       Vapor Pressure: 41.54 at 25°C

       Boiling Point:   82.2

       Density: 0.7887 at 20°C/4°C

       Octanol/Water Parti-
        tion Coefficient:  0.61

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
                                     CHEMICAL NAME
    Safety Hazard:  Fire-dangerous
                  Explosion-moderate
Physical State:  Liquid

Vapor Density:  2.55

Melting Point:  25.5°C

Solubility:   Infinite (H2O)
                                             AI-172

-------
                                                                   tort-Butyl  alcohol
                              PRODUCTION DATA

Annual U.S.
 Production:   lOOOxlo'lbs.                     Consumption:  1000 x 106 Ibs.

Fraction of                                     Fraction of Pro-
 Dispersion:   0-7                                duction Lost: 0.015

Release Rate (million Ibs/yr): 715
                                 TOXICITYDATA

Acute Toxicity              Dosage              Animal              Route
     LD50               3500 mg/kg            rat                 oral
                         933 mg/kg            mouse              intraperitoneal
     LDLo               4500 mg/kg            rabbit              oral
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA: 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
        Human skin contact: slight erythemia and hyperemia
                                       AI-173

-------
n-Butylaldehyde
                                     CHEMICAL  NAME
    CAS Number:    123-72-8

    Chemical Name:    Butyraldehyde

    Synonyms:   n-Butyl aldehyde
          Butanal
          Butyric aldehyde
    Molecular
      Formula:   C4H8O
    Structure:    CH3 - CH2 - CH2 - C
                                        O
    Chemical Properties

       Molecular Weight:     72.12

       Vapor Pressure:    <10 mm at 25°C

       Boiling Point:    75.7°C at 760 mm

       Density:  0.8170 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:  1-18
Physical State:     Liquid

Vapor Density:  2.5

Melting Point:   -99°C

Solubility:   Soluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
           Fire-dangerous
                                             AI-174

-------
                                                                   n-Buty (aldehyde
                              PRODUCTION  DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rats (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
     LDSO              2490mg/kg            rat                oral
                        2700 mg/kg            mouse             subcutaneous

Non-lethal Acute Effects:
     Irritant
        TCLo             580 mg/kg            human             inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:    Not tested


   Mutagenicity:

   Teratogenicity:                               TLV;

   Other Chronic Effects:
                                      AI-175

-------
sec-Butylamine
                                    CHEMICAL  NAME
    CAS Number:   513-49-5

    Chemical Name:    (S)2-Butanamine

    Synonyms:  sec-Butylamine
               2-Aminobutane

    Molecular
     Formula:  C4H,,N
                            NH2
                             I
    Structure:  CH3 - CH2 - CH - CH3
    Chemical Properties

       Molecular Weight:  73.14                       Physical State:   Liquid

       Vapor Pressure:  169.8 mm at 25°C                Vapor Density:

       Boiling Point:   63.0°C at 760 mm                Melting Point: .  -104.5°C

       Density:  0.724 at 20°C/4°C                     Solubility:   Soluble (H2O)'

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fiie-dangerous
                                           AI-176

-------
                                                                  sec-Butylamine
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSO '             380 mg/kg            rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AI-177

-------
tert-Butylamine
                                     CHEMICAL NAME
    CAS Number:    75-64-9

    Chemical Name:    t-Butylamine

    Synonyms:   2-Aminoisobutane
                Trimethylaminomethane

    Molecular
      Formula:   C4HnN
                       CH3
                       I
    Structure:    CH3  - C - NH2

                       CH,
    Chemical Properties

       Molecular Weight:   73.14                      Physical State:  Liquid

       Vapor Pressure: 169.8 mm at 25°C               Vapor Density: 2.5

       Boiling Point:   44 to 46°C                     Melting Point:

       Density:  0.700 at 15°C                        Solubility:   Miscible (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:    27% of theoretical

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-moderate
                                             AI-178

-------
                                                                 tert-Butylamine
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage             Animal              Route
     LDSO             180mg/kg             rat                oral
                       900 mg/kg             mouse             oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                      AI-179

-------
Butylbenzoic  acid
                                     CHEMICAL  NAME
    CAS Number:    1320-16-7

    Chemical Name:    (1,1 -DimethylethyDbenzoic acid

    Synonyms:  p-t-BBA
               TBBA
               p-tert-Butylbenzoic acid
    Molecular
      Formula:
                                        O
                                        OH
                                                4-tert-Butylbenzoic acid
                  CH3
                   I
Structure:   CH3 - C
                   I
                  CH3
    Chemical Properties

       Molecular Weight:  178.23

       Vapor Pressure:

       Boiling Point:

       Density:  1.142 at 20°C/4°C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Fire-slight
                                                Physical State:     Solid

                                                Vapor Density:

                                                Melting Point:   164.5 to 165.5°C

                                                Solubility:   Insoluble (H2O)
                                             AI-180

-------
                                                                Butylbenzoic acid
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal               Route
      LDSp              735 mg/kg             rat                 oral

Non-lethal Acute Effects:
      Local irritant
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-181

-------
Butylene


                                     CHEMICAL NAME


    CAS Number:    115-11-7

    Chemical Name:     1-Methylpropene

    Synonyms:   Isobutylene
                Isobutene

    Molecular
      Formula:
                       CH3
                        I
    Structure:    H3C  - C  =  CH2
    Chemical Properties

       Molecular Weight:  56.11                       Physical State:   Gas

       Vapor Pressure:  3290mmat40.5°C              Vapor Density:  1.94

       Boiling Point:    -6.9°C                         Melting Point:   -140.35°C

       Density:  0.5942 at 20°C/4°C (liquid)             Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-dangerous
          Explosion-dangerous
                                             AI-182

-------
                                                                              Butylene


                              PRODUCTION DATA
Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route


Non-lethal Acute Effects:
      Simple asphyxiant with narcotic action
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-183

-------
1, 3-Butylene  glycol
                                     CHEMICAL NAME
    CAS Number:    107-88-0

    Chemical Name:    1,3-Butanediol

    Synonyms:   1,3-Butylene glycol
                0-Butyleneglycol

    Molecular
      Formula:   C4H10O2
                       OH
                        I
    Structure:    CH3 - CH -  CH2 -  CH2OH
     Chemical Properties

       Molecular Weight:  90.12                      Physical State:  Liquid

       Vapor Pressure:  0.06 mm at 20°C                Vapor Density:  3.2

       Boiling Point:    207.5°C                       Melting Point:

       Density:     1.006at20°C/20°C                Solubility:   Infinite (H2O)

       Octanol/Water Parti-
         tion Coefficient:  -1-10

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
          Fire—slight
                                             AI-184

-------
                                                            1, 3-Butylene glycol
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:   Not tested


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                      AI-185

-------
n-Butyl glycidyl ether
                                    CHEMICAL NAME
    CAS Number:   2426-08-6

    Chemical Name:   (Butoxymethyl)oxiiane

    Synonyms:   n-Butyl glycidyl ether
              ~BGE
               l-Butoxy-2,3-epoxypropane
    Molecular
     Formula:
                  A
    Structure:   Z	X_ cn2  - O - CH2 - CH2 - CH2CH3
    Chemical Properties

       Molecular Weight:  130.21                     Physical State:  Liquid

       Vapor Pressure:                               Vapor Density:

       Boiling Point:    164°C                         Melting Point:

       Density:  0.91                                Solubility:   Slightly (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Explosion-dangerous
                                            AI-186

-------
                                                            n-Butyl glycidyl ether
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
      LD50
      LCLo

 Non-lethal Acute Effects:
      Irritant to skin
  Dosage
2050 mg/kg
1190mg/kg
1520 mg/kg
 700 mg/kg
2520 mg/kg
 670 ppm
Animal
rat
rat
mouse
mouse
rabbit
rat
  Route
oral
intraperitoneal
intraperitoneal
intraperitoneal
skin
inhalation
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 50 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     T LV:   50 ppm or 27 mg/m3
                                       AI-187

-------
Butylmercaptan
                                     CHEMICAL NAME
    CAS Number:    109-71-5

    Chemical Name:    1-Butanethiol
    Synonyms:   n-Butylmercaptan
                n-Butyl thioalcohol
    Molecular
      Formula:
    Structure:   CH3CH2CH2CH2SH
    Chemical Properties

       Molecular Weight:  90.19

       Vapor Pressure:  <10 mm at 25°C

       Boiling Point:    98.46°C

       Density:  0-8299 at 20°C/4°C

       Octanel/Water Parti-
         tion Coefficient:  2.28
Physical State:  Liquid

Vapor Density:  3.1

Melting Point:   -115.67°C

Solubility:   Slightly (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-dangerous
                                            AI-188

-------
                                                                    Butylmercaptan
                               PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
      LDSO               1500 mg/kg            rat                 oral
                          399 mg/kg            rat                 intratracheal
                         4020 ppm (4 hours)      rat                 inhalation
                         2500 ppm (4 hours)      mouse            ,  inhalation
                          700 ppm (30 minutes)   dog                inhalation
Non-lethal Acute Effects:
      TCLo
      Paralysis if concentrated vapor is inhaled
TCLO                10 mg/m3 (3 hours)   human             inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 10 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-189

-------
tert-Butylphenol
                                     CHEMICAL  NAME
    CAS Number:   98-544

    Chemical Name:    p-tert-Butylphenol

    Synonyms:   Hydroxy-4-tert-butyl benzene
    Molecular
      Formula:   C10H14O
                                CH3
                       s=\      I
    Structure:
C -  CH,
                                CH,
    Chemical Properties

       Molecular Weight:  150.22

       Vapor Pressure:  1 nun at 70°C

       Boiling Point:    239.5°C at 760 mm

       Density: 0.908 at 80°C/4°C

       Octanol/Water Parti-
         tion Coefficient:  3.31

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
                   Physical State:   Solid

                   Vapor Density:  5.1

                   Melting Point:   101°C

                   Solubility:   Soluble (hot H2O)
                                            AI-190

-------
                                                                 tert-Butylphenol
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
Acute Toxicity
      LDSO
 Non-lethal Acute Effects:
      Irritant
3250 mg/kg
2520 mg/kg
                                TOXICITY DATA
 Animal
rat
rabbit
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     tLV:
  Route
oral
skin
                                      AI-191

-------
tert-Butyl toluene
                                     CHEMICAL  NAME
    CAS Number:    98-51-1

    Chemical Name:     p-tett-Butyl toluene
    Synonyms:   p-Methyl-tert-butylbenzene
    Molecular
      Formula:   CuH16
    Structure:    CH3
CH3
 I
C - CH3
 I
CH,
     Chemical Properties

       Molecular Weight:  148.25

       Vapor Pressure:  <10 mm at 25°C

       Boiling Point:    193° C at 760 mm

       Density:  0.8612 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:
                   Physical State:  Liquid

                   Vapor Density.

                   Melting Point:  -52°C

                   Solubility:   Insoluble
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
          Fire-moderate
          Disaster hazard-dangerous-toxic fumes
                                             AI-192

-------
                                                                 tert-Butyl toluene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                                              Consumption:

                                              Fraction of Pro-
                                               duction Lost:
                                 TOXICITY DATA
Acute Toxicity
      LD50
      LCSo
                          Dosage
                        1500 mg/kg
                         900 mg/kg
                        2000 mg/ke
                        1500 mg/irr (4 hours)
                         248 ppm (2 hours)
Non-lethal Acute Effects:
   .  Irritant:
        TCLO              10 ppm (3 minutes)
     Central nervous system effects:
        TCLo              20 ppm (5 minutes)
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 10 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   .Other Chronic Effects:
      Liver and kidneys
 Animal
rat
mouse
rabbit
rat
mouse
                                              human
                                              human
                                              TLV:   10 ppm
  Route
oral
oral
oral
inhalation
inhalation
                   inhalation

                   inhalation
                                       AI-193

-------
n-Butyric  acid
                                     CHEMICAL NAME
    CAS Number:   107-92-6

    Chemical Name: Butyric acid

    Synonyms:   Butanoic acid
                Ethyl acetic acid
                Propyl formic acid
    Molecular
     Formula:   C4HgO2
    Structure:    CH3CH2CH2 - C - OH
               ^-^            II
                   ^^^~^-^ O
    Chemical Properties

       Molecular Weight:   88.12                      Physical State:   Liquid

       Vapor Pressure:  lmmat25.50C                 Vapor Density:  3.04

       Boiling Point:   163.53°Cat760mm             Melting Point:   -4.26°C

       Density:  0.9577 at 20°C/4°C                   Solubility:   Infinite (H2O)

       Octanol/Water Parti-
        tion Coefficient:   0.97

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-moderate
                                            AI-194

-------
                                                                        n-Butyric acid
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption: .

                      Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
      LDSO
  Dosage
2400 mg/kg
3180 mg/kg
3180 mg/kg
 800 mg/kg
 500 mg/kg
3600 mg/kg
 Non-lethal Acute Effects:
      Irritant to eyes, skin and respiratory tract
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
mouse
mouse
mouse
mouse
tabbit
                      TLV:
  Route
oral
intraperitoneal
subcutaneous
intravenous
oral
oral
                                        AI-195

-------
n-Butyric anhydride
                                    CHEMICAL NAME
    CAS Number:   106-31-0

    Chemical Name:    Butyric anhydride

    Synonyms:  n-Butyiic anhydride
               Butanoic anhydride

    Molecular
     Formula:  CgH14O3
                                     O
               CH3 - CH2 - CH2 - C x
    Structure:                          X O
               CH3 - CH2 - CH2 - C '
                                     \\
                                      0
    Chemical Properties

       Molecular Weight:  158.20

       Vapor Pressure:  <10mmat25°C

       Boiling Point:    199.4 to 201.4° at 760 mm

       Density:  0.9668 at 20°C/4°C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
                   Physical State:  Liquid

                   Vapor Density: 5.4

                   Melting Point:  -75°C

                   Solubility:   Decomposes (H2O)
Reacts with oxidizing materials
    Safety Hazard:
          Fiie-moderate
                                            AI-196

-------
                                                           n-Butyric anhydride
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal             Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:   Not tested


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                     AI-197

-------
Butyronitrile


                                      CHEMICAL NAME


     CAS Number:   109-74-0

     Chemical Name:    Butyionitrile

     Synonyms:   Butane nitrite
                N-piopyl cyanide

     Molecular
      Formula:   C4H7N
    Structure:   CH3  - CH2CH2C  =  N
     Chemical Properties

        Molecular Weight:   69.11                       Physical State:   Liquid

        Vapor Pressure:  20 mm at 25.7°C                Vapor Density:

        Boiling Point:   118°Cat760mm                Melting Point:   -112°C

        Density:  0.7936 at 20°C/4°C                   Solubility:   Slightly (H2O)

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
           Fire—dangerous
           Disaster hazard-dangerous-toxic fumes-chlorides
                                              AI-198

-------
                                                                        Butyronitrile
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                       duction Lost:
Acute Toxicity
      LDSO
      LC
                                 TOXICITY DATA
        Lo
  Dosage
500'mg/kg
 50 mg/kg
100 mg/kg
100 mg/kg
400 ppm
 Animal
rabbit
rat
mouse
guinea pig
rat
  Route
skin.
oral
oral
skin
inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:    Not tested
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
                                       AI-199

-------
Buxten
                                     CHEMICAL NAME
    CAS Number:     2282-34-0 (a and b)
    Chemical Name:    3-{l-Methylbutyl)phenol methylcarbamate

    Synonyms:  Bux
      Mixture of (a) m-
-------
                                                                                  Buxten
Annual U.S.
 Production:

Fraction of
 Dispersion:
              6xl06 Ibs.
              Estimated as 1.0

Release Rate (million Ibs/yr):     6
                               PRODUCTION DATA
Consumption:
Fraction of Pro-
 duction Lost:  0.01S
Acute Toxicity
      LDSO
      3:1 mixture (a:b)
      LDSO
      4:1 mixture (a:b)
      LDSO
                                 TOXICITY DATA
                           Dosage
                         1050 mg/kg

                          170 mg/kg
                         1400 mg/kg
                          400 mg/kg

                           87 mg/kg
                          242 mg/kg
                         1400 mg/kg
                          400 mg/kg
 Animal
rat

rat
dog
rabbit

rat
rat
dog
rabbit
  Route
oral

oral
skin
skin

oral
skin
skin
skin
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                               TLV:
                                        AI-201

-------
Cacodylic acid
                                      CHEMICAL  NAME
    CAS Number:   75-60-5

    Chemical Name:   Hydroxydimethyl arsine oxide

    Synonyms:  Dimethyl arsenic acid


    Molecular
      Formula:  C2H?As O2
    Structure:          As - OH
                CH  ' '
Physical State:  Solid

Vapor Density:

Melting Point:  200° C

Solubility:   Very soluble (H2O)
     Chemical Properties

        Molecular Weight:   138.01

        Vapor Pressure:

        Boiling Point:

        Density:

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
     Safety Hazard: ' Disaster hazard-hazardous when water solution is in contact with active metals;
                                 i.e., Fe, Al, and Zn.
                                              AI-202

-------
                                       Cacodylic acid
Annual U.S.
 Production:
              2 x 106 Ibs.
PRODUCTION DATA
               Consumption:
Fraction of
 Dispersion:  l.O

Release Rate (million Ibs/yr): 2
               Fraction of Pro-
                 duction Lost:  0.01S
  TOXICITY DATA
Acute Toxicity
                          Dosage
                        1350mg/kg
                         185 mg/kg
                         500 mg/kg
                        1000 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Carcinogenic


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                              Animal
                                              rat
                                              mouse
                                              mouse
                                              dog
                                    Route
                                  oral
                                  intra'peritoneal
                                  unknown
                                  subcutaneous
               TLV:
        AI-203

-------
Calcium  propionate
                                    CHEMICAL  NAME
    CAS Number:  4075-81-*

    Chemical Name:  Calcium propionate
    Synonyms:  Propionic acid, calcium salt
    Molecular
      Formula:  C6H10O4-Ca
    Structure:  (CH3 - CH2 - C - O(~0  Ca(LM"}
                           O
     Chemical Properties

       Molecular Weight:   186

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
Physical State: Solid

Vapor Density:

Melting Point:

Solubility:   Soluble (55.8 gm/1 H,O)
                                            AI-204

-------
                                                            Calcium propionate
                             PRODUCTION DATA

Annual U.S.
 Production:   21.4 x 106 Ibs.                    Consumption:  21.4 xlO6 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:  1.0                                 duction Lost: 0.03

Release Rate (million Ibs/yr):  22.0
                               TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                      AI-205

-------
Calcium  stearate
                                     CHEMICAL  NAME
    CAS Number:   1592-23-0

    Chemical Name:    Steaiic acid, calcium salt

    Synonyms:  Calcium salt octadecanoic acid
               Calcium steaiate
    Molecular
      Formula:
    Structure:
•     t
(CH3(CH2)16  C
Ca'
    Chemical Properties

       Molecular Weight:  681.48

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:   80% of theoretical for 5 days at 20°C

       Atmospheric Reactivity:
                                        Physical State:

                                        Vapor Density:

                                        Melting Point:  156 to 160°C

                                        Solubility:  Insoluble (H2O)
    Safety Hazard:
                                             AI-206

-------
                                                                Calcium stearate
                              PRODUCTION DATA

Annual U.S.
 Production:   37.8 x 106 Its.                     Consumption:  37.8 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:   1-0                               duction Lost:  0.03

Release Rate (million Ibs/yr): 38.9
                                TOXICITYDATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-207

-------
Camphor
    CAS Number:   76-22-2

    Chemical Name:   Camphor

    Synonyms:  2-Camphone
    Molecular
      Formula:  Ci0H16O
                                     CHEMICAL  NAME
    Structure:
     Chemical Properties

       Molecular Weight:  152.23

       Vapor Pressure: 1 mm at 41.5°C

       Boiling Point:   204°C (sublimes)

       Density: 0.992 at 25°C/4°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:  Solid

Vapor Density: 5.24

Melting Point:  174 to 179°C

Solubility:  Insoluble (H2O)
     Safety Hazard:  Fire-moderate
                  Explosion-moderate
                                            AI-208

-------
                                                                             Camphor
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                                             Consumption:

                                             Fraction of Pro-
                                               duction Lost:
Acute Toxicity
      LDSo
Non-lethal Acute Effects:

   Irritant
   Convulsions
                                TOXICITY DATA
 .Dosage
 900mg/kg
2200 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:  (air) 2 ppm (TWA)
                                              Animal
                                              rat
                                              mouse
                                                                  Route
                                                                intiaperitoneal
                                                                subcutaneous
   Carcinogenicity:  Neoplastic effect
                           84 mg/kg (1 week)
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                              mouse
                                              TLV: 5 mg/m3
                                                                 skin
                                       AI-209

-------
Caprolactam
                                    CHEMICAL  NAME
    CAS Number:   105-60-2
    Chemical Name:  Hexahydro-2H-azepin-2-one

    Synonyms:  2-Oxohexamethylenimine            2-Azacycloheptanone
               6-Aminohexanoic acid, cyclic lactam

    Molecular
      Formula:  C6HnNO
    Structure.
•OF.
     Chemical Properties

       Molecular Weight:  113.16

       Vapor Pressure: 6 mm at 120°C

       Boiling Point:  139°Cat 12mm

       Density:

       Octanol/Water Parti-
        tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
                                      Physical State: Solid

                                      Vapor Density:

                                      Melting Point:  69to71°C

                                      Solubility:   Soluble (H2O)
                                           AI-210

-------
                                                                         Caprolactam
                               PRODUCTION DATA
Annual U.S.
 Production:    950 x 106 Ibs. (1976) capacity

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                     Consumption:   660 x 10* Ibs.

                     Fraction of Pro-
                      duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
      LDso
      LDLo
 Non-lethal Acute Effects:
      Irritant:
  Dosage
2140 mg/kg
1410 mg/kg
 950 mg/kg
   7 ppm
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
rabbit
guinea pig


human
                     TLV:
  Route
oral
skin
subcutaneous
                                                                 inhalation
                                       AI-211

-------
Captan
                                       CHEMICAL  NAME


     CAS Number:   133-06-2

     Chemical Name:    N-(Trichloromethyl)thio-4-cyclohexene-l,2-dicaiboximide

     Synonyms:  Cis-N[(trichloromethyl)thio]-4-cyclohexene-l,2-dicarboximide
                Tetrahydtophthalimide
                Orthocide
     Molecular
      Formula:  C9HgCl3NO2S
                        0.
                        II
     Structure:
                        it
                        o
J
L=-_S^C^
        I
       Cl
     Chemical Properties

        Molecular Weight:  300.62

        Vapor Pressure: O.Olji at 25°C

        Boiling Point:

        Density: 1.74

        Octanol/Water Parti-
         tion Coefficient:  2.35

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
                           Physical State:  Solid

                           Vapor Density:

                           Melting Point:  JTS^C.

                           Solubility:   Insoluble (H2O)
     Safety Hazard:
                                             AI-212

-------
                                                                                 Captan

                               PRODUCTION DATA
Annual U.S.
 Production:   18 x 106 Ibs.                       Consumption:  18xl06lbs.

Fraction of                                      Fraction of Pro-
 . Dispersion:    1.0                                duction Lost: 0.01

Release Rats (million Ibs/yr):  18.1
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
     LD50               480mg/kg            rat      .           oral
                           9 mg/kg            mouse              intiapeiitoneal
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 5 mg/m3



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:  3000 mg/kg pregnant rat       oral  TLV:
                   38-mg/kg pregnant rabbit    oral
                  300 mg/kg pregnant hamster   oral
   Other Chronic Effects:
                                       AI-213

-------
Carbaryl
                                     CHEMICAL NAME


    CAS Number:  63-25-2

    Chemical Name:   Methylcarbamic acid, 1-naphthyl ester

    Synonyms:   1-Naphthyl-N-methyl caibamate
                Sevin

    Molecular
      Formula:   C12HUNO2
                    CH,  Q
                    T-3  li
    Structure:   H - N  - C - Q
     Chemical Properties

       Molecular Weight:  201.24

       Vapor Pressure:

       Boiling Point:

       Density:  1.232 at 20°C/20°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:  Solid

Vapor Density:

Melting Point:  142°C

Solubility:
     Safety Hazard:
                                            AI-214

-------
                                                                                 Carbaryl
Annual U.S.
 Production:   55 x 106 Ibs.

Fraction of
 Dispersion:    1.0

Release Rate (million Ibs/yr): 55
                                PRODUCTION DATA
                       Consumption:  55 x 106lbs.

                       Fraction of Pro-
                         duction Lost: 0.015
                                  TOXICITY DATA

Acute Toxicity                Dosage                Animal
      LD50                  89mg/kg             rat
                            48 mg/kg             tat
                          500 mg/kg   .          rat
                          396 mg/kg             mouse
                          710 mg/kg             rabbit
                          280 rag/kg             guinea pig
                          197 mg/kg             chicken
                            56 mg/kg             wild bird

Non-lethal Acute Effects:
      Central nervous system-cholinesterase inhibitor
         TDLo             2800 jig/kg             man
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 5 mg/m3
   Carcinogenicity:
      TDLo

   Mutagenicity:
57000 mg/kg (95 wks)
   80 mg/kg
tat
rat
   Teratogenicity:  388 mg/kg  pregnant dog      oral   TVL:
                 300 mg/kg  pregnant guinea pig oral
                  50 mg/kg  pregnant rat       oral
   Other Chronic Effects:
                                             Route
                                           oral
                                           intraperitoneal
                                           unknown
                                           intraperitoneal
                                           oral
                                           oral
                                           oral
                                           oral
                                           oral
oral  .
implant
                                        AI-215

-------
Carbofuran
                                     CHEMICAL  NAME
    CAS Number:   1563-66-2

    Chemical Name:    Methyl carbamic acid

    Synonyms:  2,3-Dihydro-2,2-dimethyl-7-benzofuranyl
               Carbofuran


    Molecular
      Formula:  C12H15NO3
        Methyl carbamate
        Furadan
    Structure:
                     H
               CH, - N - C - O
                  3       II
                 - -_     O
    Chemical Properties

       Molecular Weight:  2213

       Vapor Pressure:    2X10"5 mm at 33°C

       Boiling Point:

       Density: 1.180 at 20°C/20°C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:

Vapor Density:

Melting Point:   150 to 152°C

Solubility:   Slightly (H2O)
                                              AI-216

-------
                                             Carbofuran
Annual U.S.
 Production:   8 x 106 Ibs.

Fraction of               -
 Dispersion:    Estimated as 1 .0

Release Rate (million Ibs/yr):  8.0
PRODUCTION DATA
                Consumption:
                Fraction of Pro-
                 duction Lost: 0.015
  TOXICITYDATA
Acute Toxicity
     LDSO
  Dosage
  llmg/kg
  10 mg/kg
5300 Mg/kg
 120 mg/kg
   2 mg/kg
  19 mg/kg
 885 mg/kg
   6 mg/kg
      LCSO
  85 mg/m3
  52 mg/m
  32 mg/m3
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA


   Carcinogenicity:


   Mu'tagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                               Animal
                                              human
                                              human
                                              rat
                                              rat
                                              mouse
                                              dog
                                              rabbit
                                              chicken
                                              duck
                                              rat
                                              dog
                                              guinea pig
                                     Route
                                   oral
                                   skin
                                   oral
                                   skin
                                   oral
                                   oral
                                   skin
                                   skin
                                   skin
                                   inhalation
                                   inhalation
                                   inhalation
                TLV:
        AI-217

-------
Carbon  disulfide
                                     CHEMICAL  NAME
    CAS Number:    75-15-0

    Chemical Name:    Caibondisulfide

    Synonyms:   Caibonbisulfide
                Carbondisulphide
                Weeviltox
    Molecular
     Formula:   CS2
    Structure:   S = C = S
    Chemical Properties

       Molecular Weight:  76.13

       Vapor Pressure:

       Boiling Point:    46.25°C at 760 mm

       Density:   1-2632 at 20°C/4°C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Fire-dangerous
          Explosion-dangerous
Physical State:  Liquid

Vapor Density:

Melting Point:  -H1.53°C

Solubility:    Slightly soluble (H2O)
                                            AI-218

-------
                                                                   Carbon disulfide
                              PRODUCTION DATA
Annual U.S.
 Production:    767.8 x 106 Ibs.

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                      Consumption:   752 x 106 Ibs. (1966)

                      Fraction of Pro-
                       duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
      TCLo
 300 mg/kg
 400 mg/kg
4000 ppm (30 minutes)
  50 mg/m3
Animal
rabbit
rat
human
human
Chronic Toxicity

   U.S. Occupational Standard:
      (air) TWA              20 ppm
      Ceiling concentration     30 ppm
      Peak concentration	100 ppm (30 minutes/8 hours)
   Carcinogenicity:
   Mutagenicity:

   Teratoganicity:

   Other Chronic Effects:
                      TLV:
  Route
subcutaneous
intiaperitoneal
inhalation
inhalation
                                       AI-219

-------
Carbontetrabromide
                                     CHEMICAL NAME
    CAS Number:   558-134

    Chemical Name:    Carbon tetrabromide


    Synonyms:  Tetiabtomomethane
    Molecular
      Formula:  €614
                     Bi
                     I
    Structure:   Br -  C -  Br
                     I
                     Br
    Chemical Properties


       Molecular Weight:  331.67                      Physical State:  Solid


       Vapor Pressure: 44 mm at 96.3°C                Vapor Density:


       Boiling Point:   189.5°C                        Melting Point:  90.1°C


       Density:  3-42                                Solubility:  Soluble (H2O) (785 mg/1 at 20°C)


       Octanol/Water Parti-
         tion Coefficient:


    Environmental Persistence

       BOD:    No oxygen consumption in standard testing


       Atmospheric Reactivity:  Reacts with oxidizing materials.
    Safety Hazard:  Disaster hazard-dangerous-toxic fumes
                                           AI-220

-------
                                                            Carbontetrabromide
                              PRODUCTION DATA

Annual U.S.
 Production:    1000 x 106lbs. (1970)              Consumption:   1000 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:    0.01                         f     duction Lost:  0.015

Release Rate (million Ibs/yr): 60
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal               Route
                         298mg/kg  .          mouse              subcutaneous
                        lOOOmg/kg            rat                 oral
Non-lethal Acute Effects:
     Narcotic in high concentrations
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppb



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AI-221

-------
Carbon tetrachloride
                                     CHEMICAL  NAME
    CAS Number:   56-23-5

    Chemical Name:    Carbon tetrachloride

    Synonyms:     Tetrachloiomethane
                  Perchloromethane
                  Methane tetrachloride
    Molecular
      Formula:  CCL,
                     Cl
                     I
    Structure:    Cl  - C - a
                     a
    Chemical Properties

       Molecular Weight:    153.82

       Vapor Pressure:      115.2mmat25°C

       Boiling Point:  76.54°C at 760 mm

       Density:    1.5940 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:    2.64

    Environmental Persistence

       BOD:   No 02 consumption in standard BOD test

       Atmospheric Reactivity:
               Photodegradation: t% = 10 to 33 weeks
    Safety Hazard:
Physical State:    Liquid

Vapor Density:    532

Melting Point:     -22.99°C

Solubility:  insoluble (H2O)
                                            AI-222

-------
                                                               Carbon  tetrachloride
                                PRODUCTION DATA
Annual U.S.
 Production:  1,047 x 106 Ibs. (1973)

Fraction of
 Dispersion:   0.05

Release Rate (million Ibs/yr):  65
                      Consumption:    989.3 x 106 Ibs.

                      Fraction of Pro-
                        duction Lost:   0.015
                                  TOXICITY DATA
Acute Toxicity
    LDso
    LC
       SO
  Dosage
  1770mg/kg
  4620 mg/kg
  6380 ing/kg
  3200 mg/kg
  1000 mg/kg
  125 mg/kg
  4785 mg/kg
  3000 mg/kg
  9526 ppm (8 hours)
38,110 ppm (2 hours)
  550 ppm
20,000 ppm (2 hours)
 1,000 ppm
 4,000 ppm (4 hours)
  Animal
rat
mouse
rabbit
mouse
dog
dog
cat
rabbit
mouse
cat
rabbit
guinea pig
human
rat
Chronic Toxicity

   U.S. Occupational Standard:
          (air) TWA:
          Ceiling level:
          Peak concentration:
   Carcinogeniciry:
    Neoplastic effects:
       TDLo

    Carcinogenicity:
       TDLO

   Mutagenicity:
          Positive
   Teratogenicity:

   Other Chronic Effects:
       10 ppm
       25 ppm
      200 ppm/5 minutes/4 hours
   133gm/kg          rat
   (25 weeks, intermittent)

 4800 mg/kg          mouse
   (88 days, intermittent)
    Route
oral
intraperitoneal
oral
subcutaneous
oral
intravenous
subcutaneous
subcutaneous
inhalation
inhalation
inhalation
inhalation
inhalation
inhalation
                    subcutaneous
                    oral
                      TLV:   10ppm
                              Odor perception: 77 ppm
                                         AI-223

-------
Castor oil
                                      CHEMICAL  NAME
     CAS Numb*-.   8001-79-4

     Chemical Mime:   Castor oil

     Synonyms:  Ricinus oil
                Ricinolein
                Glycerides of ricinoleic and isoricinoleic acids
     Molecular  ~
      Formula:  (not given in CAS Registry Number Handbook, since the composition varies)
Structure:
   [CH3 (CH2)5 CH = CH CH = CH (CH2)? COO],



Chemical Properties

   Molecular Weight:  (Varies)

   Vapor Pressure:

   Boiling Point:   313°C (decomposes)

   Density:  0.96  at 25° C/2S°C

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
     Safety Hazard:  Fire-slight
                                                     Physical State:  Liquid

                                                     Vapor Density:

                                                     Melting Point:  -10°C

                                                     Solubility:  <5.0 gm/1 H2O (Insoluble)
                                              AI-224

-------
                                                                             Castor oil
                               PRODUCTION DATA

Annual U.S.
 Production:   100 x 106 Ibs.                     Consumption:   198 x 106 Ibs.

Fraction of                                     Fraction of Pro-
 Dispersion:    0.64                               auction Lost:  0.03

Release Rate (million Ibs/yr):    129.7 (1972)
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route

   (Low toxicity)
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-225

-------
Cellulose acetate
                                      CHEMICAL  NAME


    CAS Number:   9004-35-7

    Chemical Name:    Cellulose acetate

    Synonyms:  CA                        Acetyl cellulose
                Acetate ester of cellulose
                Acetic acid, cellulose ester
    Molecular
      Formula:   (Exact composition unknown or undetermined)
    Structure:  (Cellulose ester in which the cellulose is not completely esterified by the acetic acid.)
     Chemical.Properties

        Molecular Weight:  (undetermined)

        Vapor Pressure: Negligible

        Boiling Point:

        Density:  1.27 to 1.34

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOO:

        Atmospheric Reactivity:
     Safety Hazard:  ' Fire - moderate
Physical State:  Solid

Vapor Density:

Melting Point:  260°C (decomposes)

Solubility:  Insoluble (H2O)
                                                AI-226

-------
                                                               Cellulose  acetate
                              PRODUCTION DATA

Annual U.S.
 Production:   807.1 x 106 Ibs.                    Consumption:   820.4 x 106 ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:   0                                duction Lost:  0.03

Release Rate (million Ibs/yr):  24.6
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
   (Nontoxic)
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-227

-------
Chloranil
                                      CHEMICAL NAME
    CAS Number:   118-75-2

    Chemical Name:   2,3,5,6-Tetrachloro-p-benzoquinone

    Synonyms:   Tetrachloroquinone
                Dow seed disinfectant No. 5

    Molecular
      Formula:   C&C14 O2



                  Cl       Cl

    Structure:   O =^     y= O

                  Cl       Cl


    Chemical Properties

       Molecular Weight:  245.9

       Vapor Pressure:  1 mm at 70.7°C

       Boiling Point:  Sublimes

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:  Solid

Vapor Density:

Melting Point:  290°C (sealed tube)

Solubility:  Insoluble (H2O)
     Safety Hazard:  Disaster hazard-dangerous toxic fumes-chloride
                                              AI-228

-------
                                                                             Chloranil

                              PRODUCTION DATA
Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LD50              4000 mg/kg            rat                oral
                         500 mg/kg            rat                intraperitoneal
                           4 mg/kg            mouse             intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-229

-------
Chlordane



                                      CHEMICAL  NAME


    CAS Number:  57-74-9

    Chemical Name:  1,2,4,5,6,7,8,8-OctacMoro-3a,4,7,7a-tetiahydro-4,7-methanoindane

    Synonyms:  Chlordane
               Octaklor
               Gama-chlordan
    Molecular
      Formula:  C10H8C18
    Structure:
                   tt Trans

     Chemical Properties

       Molecular Weight:  409.76

       Vapor Pressure: 1 x 10"5 mm at 25°C

       Boiling Point:  175°C

       Density: 1-57 to 1.63 at 15.5°C/15.5°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
0Cis
    Physical State:  Liquid

    Vapor Density:

    Melting Point:

    Solubility:  Insoluble (H2O)
     Safety Hazard:
                                              AI-230

-------
                                                                              Chlordane
                               PRODUCTION DATA
Annual U.S.
  Production:   25 x 106 ibs.

Fraction of
  Dispersion:   1.0

Release Rate (million Ibs/yr): 25.3
                      Consumption:  25 x 106 Ibs.

                      Fraction of Pro-
                       duction Lost: 0.01
Acute Toxicity
      LD50
Non-lethal Acute Effects:

   CNS stimulant
                                  TOXICITY DATA
  Dosage
283 mg/kg
700 mg/kg
200 mg/kg
430 mg/kg
100 mg/kg
220 mg/kg
 40 mg/kg
 Animal
rat
rat
rat
mouse
tabbit
chicken
human
   Route
oral
skin
intraperitoneal
oral
oral
oral
oral
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 500 Mg/
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:    Liver damage
                         Kidney damage
                      TLV:0.5mg/m3
                                       AI-231

-------
Chloroacetaldehyde
                                    CHEMICAL  NAME
    CAS Number:   107-20-0

    Chemical Name:   Chloroacetaldehyde

    Synonyms:  Chloioaldehyde
               2-Chloro-l-ethanal

    Molecular
      Formula:  C2H3C1O
    Structure:   Cl - CH2 - C
     Chemical Properties

       Molecular Weight:  78.5

       Vapor Pressure:    100 mm at 45°C

       Boiling Point:   85 to 85 J°C at 748 mm
       Density: 1.19 at 25°C/25°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:  Fire-moderate
Physical State:  Liquid

Vapor Density:

Melting Point:

Solubility:  Soluble (H2O)
                                           AI-232

-------
                                                               Chloroacetaldehyde
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
     LD50
  Dosage
  23 mg/kg
   2 mg/kg
  21 mg/kg
   2 mg/kg
  67 mg/kg
1390 mg/kg
 636 mg/kg
 Animal
rat
rat
mouse
mouse
rabbit
rabbit
guinea pig
  Route
oral
intraperitoneal
oral
intraperitoneal
skin
intraperitoneal
intraperitoneal
Non-lethaj Acute Effects:
     Irritant to eyes, skin respiratory organs and mucous membranes
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 1 ppm


   Carcinogenicity:

   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
                                        AI-233

-------
Chloroacetic  acid
                                      CHEMICAL NAME
     CAS Number:  79-11-8

     Chemical Name:   Chloroacetic acid

     Synonyms:   Monochloroacetic acid


     Molecular
      Formula:   C2H3C102
               Cl    O
    Structure:  CH2 - C - OH
     Chemical Properties

        Molecular Weight:  94.50

        Vapor Pressure:  1 mm at 23°C

        Boiling Point:   187.85°C

        Density:  1.4043 at 40° C/4°C

        Octanol/Water Parti-
         tion Coefficient:  1.83

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
     Safety Hazard:  Disaster hazard-dangerous-toxic fumes^phosgene and chlorides
Physical State:  Solid

Vapor Density:  3.26

Melting Point:  63.0°C

Solubility:  Very soluble (H2O)
                                             AI-234

-------
                                                                 Chloroacetic acid
                               PRODUCTION DATA
Annual U.S.
 Production:    84 x 106 Ibs. (capacity)

Fraction of
 Dispersion: 0.01

Release Rate (million Ibs/yr):
                     Consumption:   96 x 106 Ibs. (197S)

                     Fraction of Pro-
                       duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
      LDSo

      LDLo

 Non-lethal Acute Effects:
      Irritant
  Dosage
 76 mg/kg
  5 mg/kg
500 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
rat
mouse
                      TLV:
  Route
oral
subcutaneous
intraperitoneal
                                        AI-235

-------
Chloroacetophenone
                                    CHEMICAL  NAME
    CAS Number:   532-27-4

    Chemical Name: 2-Chloroacetophenone

    Synonyms:  ^-Chlorophenyl methyl ketone
    Molecular
      Formula:  C8H7C1O
                 Cl   Vr

    Structure:
    Chemical Properties

       Molecular Weight:   154.60                     Physical State:  Solid or liquid

       Vapor Pressure:  1 mm at 48°C                  Vapor Density:

       Boiling Point:   227 to 228°C at 738 mm         Melting Point:

       Density:  1.2016 at 17°C/4°C                  Solubility:

       Octanol/Water Parti-
        tion Coefficient:   2.08

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                            AI-236

-------
                                                            Chloroacetophenone
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
Acute Toxicity
        TOXICITY DATA

  Dosage              Animal
 Non-lethal Acute Effects:
      TCLo
Irritant
93 mg/m3 (3 minutes)    human
20 mg/m (3 minutes)    human
Chronic Toxicity

   U.S. Occupational Standard:  (air) Ceiling concentration 0.05 ppm



   Carcinogenicity: Not tested
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
  Route
inhalation
inhalation
                                      AI-237

-------
m-Chloroaniline
                                    CHEMICAL  NAME
    CAS Number:      108-42-9

    Chemical Name:    m-Chloroaniline

    Synonyms:  3-Chloroaniline
    Molecular
     Formula:   C6H6C1N
                Cl
    Structure:
                 \
    Chemical Properties

       Molecular Weight:  127.52

       Vapor Pressure:  1 mm at 63.5°C

       Boiling Point:   230.5°C

       Density:  1-223 at 15°C/15°C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:  Liquid

Vapor Density:

Melting Point:   -10.6°C

Solubility:   Insoluble (H2O)
                                            AI-238

-------
                                                                  m-Chloroaniline
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSO              880mg/kg             rat                oral
                        310 mg/kg             cat                subcutaneous
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-239

-------
o-Chloroaniline
                                    CHEMICAL NAME
    CAS Number:   95-51-2

    Chemical Name:    o-Chlotoaniline

    Synonyms:     2-Chloioaniline
    Molecular
     Formula:
                 /=
-------
                                                                   o-Chloroaniline
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
      LDso              256 mg/kg             mouse             oral
      I.DLO              310 mg/kg             cat                subcutaneous
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-241

-------
p-Chloroaniline
                                     CHEMICAL NAME
    CAS Number:    106-47-8

    Chemical Name:    p-Chloroaniline

    Synonyms:   4-Chloroaniline
    Molecular
     Formula:   C6H6C1N
    Structure:   Cl
    Chemical Properties

       Molecular Weight:   127.52

       Vapor Pressure: 1 mm at 63.5°C

       Boiling Point:   232°C at 760mm

       Density:  1.429 at 19°C/4°C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:  Solid

Vapor Density:

Melting Point:   69.5°C

Solubility:    Soluble (hot H2O)
                                            AI-242

-------
                                      p-Chloroaniline
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
PRODUCTION DATA
               Consumption:

               Fraction of Pro-
                ductibn Lost:
  TOXICITY DATA
Acute Toxicity
      LD50
Dosage
300mg/kg
420 mg/kg
100 mg/kg
100 mg/kg
125 mg/kg
 36 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                              Animal
                                              rat
                                              rat
                                              mouse
                                              wild bird
                                              cat
                                              rabbit
                                    Route
                                   oral
                                   intraperitoneal
                                   oral
                                   oral
                                   subcutaneous
                                   skin
               TLV:
        AI-243

-------
o-Chlorobenzaldehyde
                                   CHEMICAL NAME
    CAS Number:   89-98-5

    Chemical Name:   o-Chlorobenzaldehyde

    Synonyms:  2-Chlorobenzaldehyde


    Molecular
     Formula:  C7H5C10

                          o
           '   VT-S,H
Chemical Properties

   Molecular Weight:  140.57

   Vapor Pressure:    10 mm at 25°C

   Boiling Point:  211.9°Cat 760 mm

   Density: 1.2483 at 20°C/4°C

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
    Safety Hazard:
                                                Physical State:  Liquid

                                                Vapor Density:

                                                Melting Point:  12.39°C

                                                Solubility:  Slightly soluble (H2O)
                                          AI-244

-------
                                                        o-Chlorobenzaldehyde
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITYDATA

Acute Toxicity              Dosage              Animal             Route
                       10 mg/kg             mouse             intiaperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:   Not tested


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AI-245

-------
p-Chlorobenzaldehyde
                                   CHEMICAL  NAME
    CAS Number:   104-88-1


    Chemical Name:    p-Chlorobenzaldehyde


    Synonyms:
    Molecular
     Formula:   C7HSC1O
                                 O
    Structure:   Cl
    Chemical Properties


       Molecular Weight:     140.57


       Vapor Pressure:


       Boiling Point:  213 to 214°C at 760 mm


       Density:  1.196 at 61°C/4°C


       Octanol/Water Parti-
        tion Coefficient:


    Environmental Persistence


       BOD:


       Atmospheric Reactivity:
    Safety Hazard:
Physical State:  Solid


Vapor Density:


Melting Point:  47.5°C


Solubility:   Soluble (H2O)
                                           AI-246

-------
                                                        p-Chlorobenzaldehyde
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             tLV:

   Other Chronic Effects:
                                      AI-247

-------
Chlorobenzene
                                     CHEMICAL  NAME
    CAS Number:   108-90-7

    Chemical Name:    Chlorobenzene

    Synonyms:  Phenyl chloride
               Monochlorobenzene
               Chlorobenzol
    Molecular
      Formula:  C6H5C1
    Structure:    /   Vci
    Chemical Properties

       Molecular Weight:  112.56

       Vapor Pressure: 12.14 mm at 25°C

       Boiling Point:   131.7°Cat760mm

       Density:  1.1058 at 20°C/4°C .

       Octanol/Water Parti-
         tion Coefficient:  2.84

    Environmental Persistence

       BOD:    1% of theoretical

       Atmospheric Reactivity:  Reacts with oxidizing materials
Physical State:  Liquid

Vapor Density:  3.88

Melting Point:   -45.6°C

Solubility:   Insoluble (H2O)
     Safety Hazard:   Fire-dangerous
                   Explosion-moderate
                                             AI-248

-------
                                                                     Chlorobenzene
                              PRODUCTION DATA
Annual U.S.
 Production:   690 x 106lbs. (1976 capacity)

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                      Consumption:

                      Fraction of Pro-
                       duction Lost:  0.01S
Acute Toxicity
     LD5o

     LDLo

Non-lethal Acute Effects:
     Strong narcotic'
2910mg/kg
2830 mg/kg
4000 mg/kg
                                TOXICITY DATA
 Animal
rat
rabbit
rat
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 75 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:    Kidney damage
                        Liver damage
                      TLV: 75 ppm
  Route
oral
oral
subcutaneous
                                       AI-249

-------
Chlorobenzilate
                                     CHEMICAL  NAME
    CAS Number:   510-15-6

    Chemical Name:    4,4'-Dichlorobenzilic acid, ethyl ester

    Synonyms:  Acaiadben
               Benzilic acid, 4,4'-dichloroethyl ester
               Chlorobenzilate
    Molecular
      Formula:  C16H,4C12 O3
                          OH
    Structure:   Cl
                            COOCH2CH3
    Chemical Properties

       Molecular Weight:  325.20

       Vapor Pressure:

       Boiling Point:   148°C at 0.04 mm

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:
Physical State:  Liquid

Vapor Density:

Melting Point:

Solubility:
                                             AI-250

-------
                                                                  Chlorobenzilate
                              PRODUCTION DATA

Annual U.S.
 Production:   2 x 106 Ibs.                       Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion: 1-0                                 duction Lost: 0.015

Release Rate (million Ibs/yr):  2.0
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSO               700 mg/kg            rat                oral
                         724 mg/kg            mouse             oral
      LC5o               500 ppm             mammal           inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  TDLo     71 mg/kg  (82 weeks)  mouse              oral


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-251

-------
Chlorobenzoic acid
                                      CHEMICAL NAME
                    2-: 118-91-2
    CAS Number:    ^535-80-8
                    4^74-11-3
    Chemical Name:   Chlorobenzoic acid (2-, 3- and 4-)

    Synonyms:    Chlorobenzoic acid (o-, m-, and p-)
    Molecular
      Formula:   C?H5C1O2
                /~
    Structure:   f    V C
                \—/  ~"
                   2-
                            O
OH
                                                 O
OH
                                                                       O
OH
     Chemical Properties

       Molecular Weight:  156.57

       Vapor Pressure:

       Boiling Point:   (2-) and (3-) sublime

       Density:  (2-) 1.544 gm/ml (20°C)
                (3-) 1 496 gm/mg (25°C/4°Q
       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
                        Physical State:  Solid

                        Vapor Density:

                        Melting Point:  (2-) 142°C (3-) 158°C
                                      (4-) 243° C
                        Solubility:  (2-) Slightly soluble in hot water
                                   (3-) Very soluble in hot water
                                   (4-) Slightly soluble in hot water
     Safety Hazard:
                                             AI-252

-------
                                                            Chlorobenzoic acid
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                     AI-253

-------
o-Chlorobenzoyl chloride
                                    CHEMICAL  NAME



    CAS Number:   609-65-4

    Chemical Name:   o-Chlorobenzoyl chloride

    Synonyms:  2-Chlorobenzoic add chloride



    Molecular
      Formula:  C?H4C12 O
                    Q
                     \\
                     C-C1
    Structure:   /  V
                       Cl
    Chemical Properties

       Molecular Weight:  175.02                      Physical State:  Liquid

       Vapor Pressure:                                Vapor Density: 5.55

       Boiling Point:   238°C at 760 mm                Melting Point:  -4 to -6°C

       Density: 1.270 to 1.280 at 25°C/1S°C            Solubility:  Decomposes (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
                                            AI-254

-------
                                                    o-Chlorobenzoyl chioride
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:  .                                  duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Careinogenicity:    Not tested


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                     AI-255!,

-------
o-Chlorobenzylidene  malononitrile
                                   CHEMICAL  NAME
    CAS Number:  18270-61-6

    Chemical Name:   o-Chlorobenzylidene malonitrile

    Synonyms:  OCBM


    Molecular
     Formula:  C10H5C1N2
    Structure:
                  =  C-C-C=N
                         CH
    Chemical Properties

       Molecular Weight: 188.62

       Vapor Pressure:

       Boiling Point:  313°C

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State: Solid

Vapor Density:

Melting Point:

Solubility:
                                          AI-256

-------
                                         o-Chlorobenzylidene  malononitrile
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
                                TOXICITY DATA
Acute Toxicity
     LDSO
 Dosage
178 mg/kg
 48 mg/kg
 35 mg/kg
282 mg/kg
 50 mg/kg
  8 mg/kg
 Animal
rat
rat
rat
mouse
mouse
rabbit
  Route
oral
intraperitoneal
intravenous
oral
intraperitoneal
intravenous
Non-lethal Acute Effects:
     Central nervous system-TCLo 1500 mg/m (90 minutes) human inhalation
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
                                       AI-257

-------
Chlorodifluoroethane
                                    CHEMICAL  NAME
    CAS Number:   75-68-3
    Chemical Name: Chlorodifluoroethane

    Synonyms:   1 Chloro-1,1-difluoroethane
    Molecular
      Formula:   C2H3C1F2
    Structure:   F -
Cl
 I
C  - CH,
    Chemical Properties

       Molecular Weight:   100.50

       Vapor Pressure:

       Boiling Point:   -9.2°C

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
                              Physical State:  Gas

                              Vapor Density:

                              Melting Point:  -130.8°C

                              Solubility:   Insoluble (H2O)
                                            AI-258

-------
                                                          Chlorodifluoroethane
                              PRODUCTION DATA

Annual U.S.
 Production:   0.2 x 106 Ibs. (1972)              Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:   0.01                              duction Lost:  0.015

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
      Asphyxiant at high concentrations





Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                      AI-259

-------
Chlorodifluoromethane
                                    CHEMICAL NAME


    CAS Number:  75-45-6

    Chemical Name:   Chlorodifluoiomethane

    Synonyms:  Freon-22
               Fluoiocarbon-22

    Molecular
      Formula:  CHC1F2



                   g
                    i"
    Structure:   H - (L - F

               	JF	



    Chemical Properties

       Molecular Weight:  86.5                        Physical State: Gas

       Vapor Pressure:    2210.6 mm at 25°C            Vapor Density:

       Boiling Point:  -40.8°C                        Melting Point: -160°C

       Density: 3.87 that of air at 0°C                  Solubility:  Partly soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
                                            AI-260

-------
                                                       Chlorodif luoromethane
                             PRODUCTION DATA

Annual U.S.
 Production:   80 x 10s Ibs. (1972)                Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost: 0.015

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Asphyxiant at high concentrations




Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                      AI-261

-------
2-Chloro-4-ethylamino-6-isopropylamino-s-triazine
                                   CHEMICAL NAME


    CAS Number:   1912-24-9

    Chemical Name:    2-Chloro-4-(ethylamino)-6-isopiopylainino-s-triazine

    Synonyms:  Atrazine
    Molecular
     Formula:  CgH14ClNs
                                  _CL
                                   c
                               •t-     \
                             N          N
    Structure:
              CH3 CH2 - NH - C
C - NH - CH
               CH,
                                                       CH,
    Chemical Properties

       Molecular Weight:  215.72

       Vapor Pressure:  3.0 x 10~7Torrsat 20°C

       Boiling Point:

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
        Physical State:  Solid

        Vapor Density:

        Melting Point:  175°C

        Solubility:   Slightly (hot H2O)
                                          AI-262

-------
                2-Chloro-4-ethylamino-6-isopropylamino-s-triazine
                            PRODUCTION DATA
Annual U.S.
 Production:   110xl06lbs.

Fraction of
 Dispersion:   1-0

Release Rate (million Ibs/yr): 111.1
                   Consumption:   110 x 106 Ibs.

                   Fraction of Pro-
                     duction Lost:  0.01
                              TOXICITY DATA
Acute Toxicity
     LDSO
  Dosage
1750 mg/kg
1750 mg/kg
3080 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
mouse
rat
                    TLV:
  Route
oral
oral
unknown
                                    AI-263

-------
Chloroform
    CAS Number:   67-66-3

    Chemical Name:   Chloroform

    Synonyms:   Trichloromethane
                Methenyl chloride

    Molecular
      Formula:   CHC13
                     Cl
                      I
    Structure:    Cl  - C  -  H
                      I
                     a
                                      CHEMICAL  NAME
     Chemical Properties

       Molecular Weight:  119.39

       Vapor Pressure:  200 mm at 25.9°C

       Boiling Point:    61.26°C

       Density:  1.49845 at 15°C

       Octanol/Water Parti-
         tion Coefficient:  1.17

     Environmental Persistence

       BOD:    4% of theoretical for S days at 20°C
                Total theoretical oxygen demand grn/gm=0.19
       Atmospheric Reactivity:   Activity toward OH: ty2 = >1 yr.
Physical State:  Liquid

Vapor Density: 4.12

Melting Point:  -63.5°C

Solubility:  Soluble (H2O) (8.0 gm/1)
    Safety Hazard:   Fire-Slight
                   Disaster hazard-dangerous-toxic fumes-phosgene
                                              AI-264

-------
                                                                             Chloroform
                                PRODUCTION DATA
Annual U.S.
 Production:   234.7 x 106 Ibs.

Fraction of
 Dispersion:    P.70

Release Rate (million Ibs/yr):    167.8
                       Consumption:  234.7

                       Fraction of Pro-
                         duction Lost: 0.015
Acute Toxicity
      LD50

      LDLo
      LCSO


      LCLo
                                  TOXICITY DATA
   Dosage
  800 mg/kg
  704 mg/kg
 2500 mg/kg
 1000 mg/kg
   75 mg/kg
  800 mg/kg
   28 ppm
  100 ppm
   59 ppm
 8000 ppm (4 hours)
20000 ppm (2 hours)
Non-lethal Acute Effects:
      Systemic effects
        (Liver or kidney)    10 ppm (1 year)
      Motor reflexes-rabbit
      Kidney, liver and vascular lesions	
 Animal
mouse
dog
dog
rabbit
mouse
dog
rabbit
rat
guinea pig
                       human
  Route
oral
oral
intravenous
subcutaneous
inhalation
inhalation
inhalation
inhalation
inhalation
                   inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 50 ppm, but NIOSH has recommended TWA 10 ppm
   Carcinogenicity: TDLo      18 gm/kg (120 days)    mouse
                                           oral
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                       TLV:

 Irritation of eyes and mucous membranes
 CNS paralysis after prolonged exposure
 Placen tal lesions
 Alteration in neuroendocrine system
                                         AI-265

-------
Chloronaphthalene
                                    CHEMICAL  NAME
    CAS Number:   90-13-1
    Chemical Name:   1-Chloronaphthalene
    Synonyms:  a-Chloronaphthalene
                 Chloronaphthalene

    Molecular
      Formula:  C]0H7C1
    Structure:
    Chemical Properties

       Molecular Weight:   162.61

       Vapor Pressure:  1 mm at 80.6°C

       Boiling Point:   259°C at 753mm

       Density: 1.1938 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:   Fire-slight
Physical State:  Liquid

Vapor Density:

Melting Point:  -2.3"C

Solubility:   Insoluble (H2O)
                                            AI-266

-------
                                                                Chloronaphthalene
                               PRODUCTION DATA

Annual U.S.
 Production:   5 x 106 Ibs. (1972)                 Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:    0.01                               duction Lost:  0.015

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
      LDSO               1540mg/kg            rat                 oral
                         1091 mg/kg            mouse              oral

Non-lethal Acute Effects:

      Conjunctivitis
      Jaundice
      Vomiting
      Highly toxic by ingestion, inhalation, and skin absorption
      Strong irritant
Chronic Toxicity

   U.S. Occupational Standard:
       (Tolerance: 2 mg/m )
   Carcinogenicity: Not tested


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                        AI-267

-------
m-Chtoronftrobenzene
                                     CHEMICAL NAME
    CAS Number:   88-73-3

    Chemical Name:    l-Chloro-3-nitrobenzene

    Synonyms:  m-Chloronitrobenzene
    Molecular
      Formula:  C6H4C1NO2
                        , N02

    Structure:   a -//   \
    Chemical Properties

       Molecular Weight:  157.6                       Physical State:  Solid

       Vapor Pressure:    <10mmat25°C              Vapor Density:

       Boiling Point:   236°C                         Melting Point:  44°C

       Density:  1.534 at 20°C/4°C                    Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:  2.41

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-slight
                   Disaster hazard-dangerous-toxic fumes-nitrate and phosgene
                                            AI-268

-------
                                                              m-Chloronitrobenzene
                              PRODUCTION DATA
Annual U.S.
 Production:   142 x 106 Ibs. (1967)

Fraction of
 Dispersion:   . 0.01

Release Rate (million Ibs/yr):
                                              Consumption:

                                              Fraction of Pro-
                                               duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
      LDSO
                           Dosage
                         288 mg/kg
                         135 mg/kg
Non-lethal Acute Effects:
      £ye  TCLo          12 mg/m3
      intoxication
      Methemoglobin, cyanosis and blood changes
      Poisoning by pulmonary route
      Irritation of nose and throat
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Not tested


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
mouse
                                              human
                                              TLV:  Ippm
  Route
oral
oral
                                                                 inhalation
                                       AI-269

-------
o-Chloronitrobenzene
                                     CHEMICAL  NAME
    CAS Number:   88-73-3

    Chemical Name:    l-Chloro-2-nitrobenzene
    Synonyms:   l-Chloro-2-nitrobenzene
    Molecular
      Formula:  C6H4C1NO2
               Cl
    Structure:
NO.,
                      /
     Chemical Properties

       Molecular Weight:  157.6

       Vapor Pressure:

       Boiling Point:   245 to 246°C at 760 nun

       Density:  1.305

       Octanol/Water Parti-
         tion Coefficient:
                            Physical State:   Liquid

                            Vapor Density:

                            Melting Point:   33.5 Joj35J)°C_

                            Solubility:   Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fire-slight
                   Disaster hazard-dangerous—toxic fumes—nitrate and phosgene
                                             AI-270

-------
                                                           o-Chloronitrobenzene
                              PRODUCTION DATA
Annual U.S.
 Production:   142 x 106 Ibs. (1967)

Fraction of
 Dispersion:   0-01

Release Rate (million Ibs/yr):
                    Consumption:

                    Fraction of Pro-
                      duction Lost: 0.015
                                TOXICITY DATA
Acute Toxicity
     LDSO


Non-lethal Acute Effects:
 Dosage
288 mg/kg
135 mg/kg
      Anemia
      Irritation of eyes, nose, and throat
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat  ;
mouse
                    TLV:  Ippm
  Route
oral
oral
                                       AI-271

-------
p-Chloronftrobenzene
                                     CHEMICAL  NAME
    CAS Number:   100-00-5

    Chemical Name:    1 -Chloro-4-nitrobenzene

    Synonyms:  p-Chloronitrobenzene
               p-Nitrochlorobenzene

    Molecular
      Formula:  C6H4ON02
    Structure:   Cl -/   V NO2
               \   \	y
    Chemical Properties

       Molecular Weight:  157.6

       Vapor Pressure: 10mmat25°C

       Boiling Point:   242°C

       Density:  1.520 at 22°C/4°C

       Octanol/Water Parti-
         tion Coefficient:  2.41

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:  Solid

Vapor Density:  5.43

Melting Point:  83°C

Solubility:   Insoluble (H2O)
     Safety Hazard:  Fire-slight
                  Disaster hazard—dangerous -toxic fumes-nitrate and chlorides
                                            AI-272

-------
                                                            p-Chtoronftrobenzene
                             PRODUCTION DATA

Annual U.S.
 Production:   142 x 106 Ibs. (1967)               Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:   0.01                              duction Lost: 0.015

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
     LDSO              1414 mg/kg            mouse             oral
                       420 mg/kg            mammal            intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 1 mg/m3



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AI-273

-------
1-Chtoro-l-nitropropane
                                    CHEMICAL  NAME
    CAS Number:   600-25-9

    Chemical Name: l-Chloro-1-nitropropane

    Synonyms:


    Molecular
      Formula:   C3H6aNOj



                     Q

    Structure:   Q2N - C - CH2 - CH3
    Chemical Properties

       Molecular Weight:   123.5

       Vapor Pressure:

       Boiling Point:   139.5°C

       Density:  1.209at20°C/20°C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:   Fire-moderate
                   Explosion-dangerous
                   Disaster hazard-toxic fumes
Physical State:   Liquid

Vapor Density:  4.26

Melting Point:

Solubility:  Slightly soluble (H2O)
                                            AI-274

-------
                                                           1-Chloro-l-nitropropane
                               PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LD;o              510 mg/kg              mouse              oral
                         165 mg/kg              mouse              subcutaneous
         Lo               50 mg/kg              rabbit              oral
Non-lethal Acute Effects:
    Irritant
    Severe pulmonary edema after inhalation or ingestion
Chronic Toxicity

   U.S. Occupational Standard:   (air) 20 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-275

-------
m-Chtorophenol
                                     CHEMICAL  NAME
    CAS Number:   108-43-0

    Chemical Name:    m-Chlotophenol

    Synonyms:    3-Chlorophenol
    Molecular
      Formula:  C6HSC1O
               Cl

    Structure:    /   V OH
    Chemical Properties

       Molecular Weight:  128.6

       Vapor Pressure:  1 mm at 44.2°C

       Boiling Point:    214°C

       Density:  1-268 at 25°C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Physical State:  Solid

Vapor Density:

Melting Point:  33°C

Solubility:   Slightly soluble (H2O)
    Safety Hazard:   Disaster hazard-toxic fumes
                                            AI-276

-------
                                                                      m-Chlorophenol
                               PRODUCTION  DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LDSO               570mg/kg            rat                 oral
                         355 mg/kg            rat                 intiaperitoneal
                         1390mg/kg            rat                 subcutaneous
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
        Irritant
                                       AI-277

-------
o-Chlorophenol
                                      CHEMICAL  NAME
    CAS Number:   95-57-8

    Chemical Name:    o-Chlorophenol

    Synonyms:   2-Chlorophenol
    Molecular
      Formula:   C6H5C1O
                       Cl
Structure:
                      /
                         OH
     Chemical Properties

       Molecular Weight:   128.6

       Vapor Pressure:  2.97 at 25°C

       Boiling Point:    174.5°C

       Density:  1.256 at 25°C/25°C

       Octanol/Water Parti-
         tion Coefficient:   2.19

     Environmental Persistence

       BOD:   100% of theoretical after 36 days
                                                Physical State:  Liquid

                                                Vapor Density:

                                                Melting Point:  7°C

                                                Solubility:   Slightly (H2O)
       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard: . Fire-moderate
                                              AI-278

-------
                                                                        o-Chlorophenol
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
                                 TOXICITY DATA
Acute Toxicity
     LDso
      LD
        'Lo
 Dosage
670 mg/kg
230 mg/kg
950 mg/kg
670 mg/kg
440 mg/kg
950 mg/kg
800 mg/kg
 Animal
rat
rat
rat
mouse
mammal
rabbit
guinea pig
  Route
oral
intraperitoneal
subcutaneous
oral
oral
subcutaneous
subcutaneous
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:   Neoplastic effect TDi,0   38 gm/kg (12 weeks)  mouse
                                              skin
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
                                       AI-279

-------
p-Chtorophenol
                                     CHEMICAL NAME
    CAS Number:   106-48-9

    Chemical Name:    p-Chloiophenol

    Synonyms:  4-Chlorophenol


    Molecular
      Formula:  C6Hsao
    Structure:   Cl-
    Chemical Properties

       Molecular Weight:  128.56                      Physical State:  Solid

       Vapor Pressure: 1 mm at 49.8°C                 Vapor Density:

       Boiling Point:   220°C                         Melting Point:  42 to 43°C

       Density: 1.246 at 60°C/25°C                   Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:  2.44

    Environmental Persistence

       BO D:   100% of theoretical after 36 days
       Atmospheric Reactivity:
    Safety Hazard:   Fire-moderate
                                            AI-280

-------
                                                                      p-Chlorophenol
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LD50               500mg/kg            rat                 oral
                         281 mg/kg            rat                 intiaperitoneal
                        1030 mg/kg            rat                 subcutaneous
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-281

-------
Chloroprene
                                      CHEMICAL NAME
    CAS Number:   126-99-8

    Chemical Name:    2-Chloro-l,3-butadiene

    Synonyms:  2-Chlorobutadiene-l,3
                0-Chloroprene
                Chloroprene
    Molecular
      Formula:  C4H5a
                       a
                       !
    Structure:   CH2 = C-CH=CH2
     Chemical Properties

        Molecular Weight:  88.54

        Vapor Pressure:   215.4 mm at 25°C

        Boiling Point:    59.4°C

        Density:  0.9583 at 20°C/4°C

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:
Atmospheric Reactivity:
   Activity toward RO2
                 Oj  t
                 OH t
                                              Physical State:  Liquid

                                              Vapor Density:

                                              Melting Point:

                                              Solubility:    Slightly <10.0 gm/1 (H20)
                               w = 2.2 yrs.
                               = 2 hrs. producing 2-chloroacrolein
                               = 21 hrs.
           Photochemical degradation:  reacts with reducing materials

     Safety Hazard:   Disaster hazard -dangerous chlorides
                                               AI-282

-------
                                                                             Chloroprene
Annual U.S.
 Production:

Fraction of
 Dispersion:
              396 x 106 Ibs.
              0.01
                                PRODUCTION DATA
Consumption:
Fraction of Pro-
 duction Lost:  0.015
Release Rate (million Ibs/yr): 6.02
                                  TOXICITY DATA
Acute Toxicity
      LDLo
                           Dosage
                         1600 mg/kg
                          500 mg/kg
                         1000 mg/kg
                          300 mg/kg
                           96 mg/kg
                          600 mg/m3 (8 his)
                         2500 mg/m3 (8 hrs)
Non-lethal Acute Effects:  80 ppm
      Central  nervous system depression
          _TCLg_80 ppm~~
      Degeneration of liver and kidneys
      Dermatitis
      Conjunctivitis-corneal necrosis
      Anemia
      Embryotoxic         	
 Animal
rat
rat
mouse
cat
rabbit
mouse
cat
                                               human
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:
      TDLo   39 mg/m  (4 hrs per day for 48 days)   rat
   Teratogenicity:                                 TLV:

   Other Chronic Effects:
  Route
oral
subcutaneous
subcutaneous
subcutaneous
intravenous
inhalation
inhalation
                   inhalation
                                                                   inhalation
                                         AI-283

-------
Chloropropham
                                      CHEMICAL  NAME


    CAS Number:   101-21-3

    Chemical Name:    m-Chlorocarbanilic acid, isopropyl ester

    Synonyms:  Isopropyl-N-(3-chlorophenyl) carbonate
                Isopropyl- m-chlorocarbanilate
                Chloropropham
    Molecular
      Formula:  c10H12aNO2
     Chemical Properties

        Molecular Weight:   213.7                       Physical State:  Solid

        Vapor Pressure:                                 Vapor Density:

        Boiling Point:  247°C  (decomposes)              Melting Point:  36°C

        Density:                                       Solubility:

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
     Safety Hazard:  Disaster hazard-dangerous toxic fumes of phosgene
                                              AI-284

-------
                                                                     Chtoropropham
Annual U.S.
 Production:  2 x 106 Ibs.

Fraction of
 Dispersion:  1:0

Release Rate (million Ibs/yr):   2.0
                              PRODUCTION DATA
                    Consumption:
                    Fraction of Pro- ,
                      duction Lost:  0.015
Acute Toxicity
      LDSO
1200mg/kg
5000 mg/kg
                                TOXICITY DATA
Animal
rat
rabbit
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:
       Neoplasm   TDLo

   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
  60 mg/kg
                     mouse
                    TLV:
 Route
oral
oral
                   oral
                                      AI-285

-------
m-Chlorotoluene
                                     CHEMICAL NAME
    CAS Number:   108-41-8
    Chemical Name:    m-Chlorotoluene
                     3-Chloro-l-methylbenzene
    Synonyms:
    Molecular
      Formula:  C7H7C1
    Structure:    Cl —u     ,>
    Chemical Properties

       Molecular Weight:  126.6

       Vapor Pressure:    4.17 mm at 25°C

       Boiling Point:   162.3°C

       Density:  1.0797 at 13.90° C/4°C

       Octanol/Water Parti-
         tion Coefficient:  3.28

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:   Fire-slight
Physical State:  Liquid

Vapor Density:

Melting Point:  -48.0°C

Solubility:  Insoluble (H2O)
                                             AI-286

-------
                                                                   m-Chlorotoluene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                   Consumption:

                   Fraction of Pro-
                    duction Lost:
Acute Toxicity
      TOXICITY DATA

Dosage              Animal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity: Not tested


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                   TLV:
Route
                                      AI-287

-------
o-Chlorotoluene
                                      CHEMICAL  NAME
    CAS Number:  9S^t9-8

    Chemical Name:   o-Chlorotoluene

    Synonyms:  2-Chloro-l-methylbenzene
                a-Chlorotoluene

    Molecular
      Formula:   C7H7C1
                      Cl

    Structure:    /   V
    Chemical Properties

       Molecular Weight:   126.6

       Vapor Pressure:  4.11 mm at 25°C

       Boiling Point:   1S9.3°C

       Density:: 1.1018 at 0°C/4°C

       Octanol/Water Parti-
         tion Coefficient:   3.42

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-slight
Physical State: Liquid

Vapor Density:

Melting Point:  -35.1°C

Solubility:   Insoluble (H2O)
                                              AI-288

-------
                                                                      o-Chlorotoluene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
     LDso
Non-lethal Acute Effects:
     TCLo
  Dosage
1231 mg/kg
1000 mg/kg
1624 mg/kg
  16 ppm
 Animal
rat
rat
mouse
human
  Route
oral
subcutaneous
oral
inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 1 ppm



   Carcinogenicity:    Neoplastic effects-TDL0 2100 mg/kg (51 weeks)   rat      subcutaneous
   Mutagenicity:
          i
   Teratogenicity:

   Other Chronic Effects:
                      TLV:
                                       AI-289

-------
p-Chlorotoluene
                                     CHEMICAL  NAME
    CAS Number:   106-43-4

    Chemical Name: p-Chlorotoluene

    Synonyms:  4-Chtoio-l-methyltoluene
               p-Tolylchloride

    Molecular
      Formula:  C7H7C1
    Structure:   CH
                 —3
Cl
    Chemical Properties

       Molecular Weight:  126.6

       Vapor Pressure:'-    406 mm at 25°C

       Boiling Point:   162.3°C at 760 mm

       Density:  1.0697 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:  3.33

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:   Fire-slight
                       Physical State:  Liquid

                       Vapor Density:

                       Melting Point:  7.5°C

                       Solubility:   Insoluble (H2O)
                                             AI-290

-------
                                                                   p-Chlorotoluene
                              PRODUCTION DATA

Annual U.S.
 Production:    95 x 106 Ibs. (1976 capacity)         Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:    0.01                             duction Lost: 0.015

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal               Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Not tested


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-291

-------
Citric acid
                                     CHEMICAL NAME


    CAS Number:   77-92-9

    Chemical Name: Citric acid

    Synonyms:   0-Hydroxytricarballylic acid
                2-Hydroxy-l,2,3-propane tricarboxylic acid

    Molecular
      Formula:   C6H8O7
                    CH2-COOH
                     I
    Structure:    HO-C-COOH
                    • I
                    CH2-COOH
     Chemical Properties

       Molecular Weight:   210.2                       Physical State:   Solid

       Vapor Pressure:                                Vapor Density:

       Boiling Point:    Decomposes                    Melting Point:   153°C

       Density:   1.542                               Solubility:   l,618gm/l(H2O)

       Octanol/Water Parti-
         tion Coefficient:   1.80

     Environmental Persistence

       BOD:     53% of theoretical
                 Total theoretical oxygen demand gm/gm = 0.75
       Atmospheric Reactivity:
     Safety Hazard:
                                             AI-292

-------
                                                                                Citric acid
                                PRODUCTION DATA
Annual U.S.
 Production: 163.0 x 106 Ibs.

Fraction of
 Dispersion:  0.75

Release Rate (million Ibs/yr):  119.2
                      Consumption:    152.4 x 106 Ibs.

                      Fraction of Pro-
                       duction Lost:   0.03
                                  TOXICITY DATA
Acute Toxicity
       LD50
  Dosage
884 mg/kg
961 mg/kg
 42 mg/kg
330 mg/kg
 Non-lethal Acute Effects:
       Irritant with allergenic effects
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
mouse
mouse
rabbit
                      TLV:
 Route
intraperitoneal
intiaperitoneal
intravenous
intravenous
                                         AI-293

-------
Crag herbicide 1
                                      CHEMICAL  NAME


    CAS Number:   136-78-7

    Chemical Name:    2-(2,4-Dichloiophenoxy)ethanol, hydrogensulfate sodium salt

    Synonyms:  Crag herbicide                         Sodium 2,4-dichlorophenyl cellosolve sulfate
                Sesone
                Sodium 2-(2,4-dichlorophenoxy)ethyl sulfate
    Molecular
      Formula:  C8H7Cl2O5S-Na
    Structure:      C1 ~(   V , OCH2 - CH2 - O - SO2(")ONa^>
                             Cl
     Chemical Properties

        Molecular Weight:   310.12                       Physical State:     Solid

        Vapor Pressure:                                 Vapor Density:

        Boiling Point:                                  Melting Point:   24S°C

        Density:                                       Solubility:   Soluble (H2O)

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
     Safety Hazard:
                                              AI-294

-------
                                                                Crag herbicide 1
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
     LDSO              730 mg/kg             rat                oral
Chronic Toxicity

   U.S. Occupational Standard:  (aii) TWA 15 mg/m3



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                      AI-295

-------
m-Cresol
                                      CHEMICAL  NAME
    CAS Number:   108-39-4

    Chemical Name: m-Cresol

    Synonyms:   m-Methylphenol
                m-Hydroxytoluene

    Molecular
      Formula:   CH3 Cfi H2 OH
    Structure:
    Chemical Properties

       Molecular Weight:   108.1

       Vapor Pressure:  1 mm at 52.0°C

       Boiling Point:   202.8°C

       Density:  1.034 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:   2.37
Physical State:  Liquid

Vapor Density:  3.72

Melting Point:  12°C

Solubility:    Slightly soluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Fire-moderate
                   Explosion-moderate
                   Disaster hazard-dangerous toxic fumes
                                              AI-296

-------
                                                                               m-Cresol
                               PRODUCTION DATA

Annual U.S.
 Production:  31.4 x 106 ibs. (1973) (m and p cresol)  Consumption:
Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                      Fraction of Pro-
                       duction Lost: 0.015
                                 TOXICITY DATA
Acute Toxicity
      LDSO

      LDLo
  Dosage
 242 mg/kg
2050 mg/kg
 180 mg/kg
1400 mg/kg
 280 mg/kg
Non-lethal Acute Effects:
          CNS disorders
          Kidney and liver damage
          Irritation of skin and eyes
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA: 5 ppm



   Carcinogenicity:
 Animal
rat
rabbit
cat
rabbit
rabbit
  Route
oral
skin
subcutaneous
oral
intravenous
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:  5ppm
                                        AI-297

-------
o-Cresol
    CAS Number:  9548-7

    Chemical Name:    o-Cresol

    Synonyms:  o-Cresylic Acid
                o-Hydroxy toluene

    Molecular
      Formula:  C7H8O
                                      CHEMICAL  NAME
                       CH
    Structure:
                \   //
                    '3
                    OH
                                                      Physical State:  Solid

                                                      Vapor Density:  3.72

                                                      Melting Point:   30.9°C

                                                      Solubility:   Soluble (H20) (31 gm/1)
Chemical Properties

   Molecular Weight:   108.1

   Vapor Pressure:  1 mm at 38.2°C

   Boiling Point:    190.8°C

   Density:  1.047 at 20°C/4°C

   Octanol/Water Parti-
    tion Coefficient:   3.40

Environmental Persistence

   BOD:    95% of theoretical at 6 days
            Toxic to sewage organisms
   Atmospheric Reactivity:   Reacts with oxidizing materials
                          Less than a day in air     t  Yields quinones and
                          Less than 10 days in water I  benzenes
     Safety Hazard:  Fire-moderate
                   Explosion-slight
                   Disaster hazard -dangerous-toxic fumes
                                              AI-298

-------
                                                                                 o-Cresol
                               PRODUCTION DATA
Annual U.S.
 Production:   49.7 x 106 Ibs.

Fraction of
 Dispersion:    0.3

Release Rate (million Ibs/yr): 15.6
                      Consumption:  49.7

                      Fraction of Pro-
                        duction Lost:  0.015
Acute Toxicity
     LDso
                                  TOXICITY DATA
  Dosage
 121 mg/kg
HOOmg/kg
 344 mg/kg
1380 mg/kg
 410 mg/kg
  55 mg/kg
 940 mg/kg
 450 mg/kg
 180 mg/kg
 360 mg/kg
 200 mg/kg
 Animal
rat
rat
mouse
rabbit
mouse
cat
rabbit
rabbit
rabbit
guinea pig
frog
  Route
oral
skin
oral
skin
subcutaneous
subcutaneous
oral
subcutaneous
intravenous
intxaperitoheal
subcutaneous
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 5 ppm



   Carcinogenicity:    20% benzene solution-papilloma in mouse


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:    Abnormal mitotic effects
                                        AI-299

-------
p-Cresol
    CAS Number:   106-44-5

    Chemical Name:   p-Cresol

    Synonyms:   4-Cresol
                4-Methylphenol
                p-Hydroxytoluene
    Molecular
      Formula:   C7H8O
    Structure:
c  •OH/~V
CH,
     Chemical Properties

       Molecular Weight:   108.1

       Vapor Pressure:  1 mm at 53.0°C

       Boiling Point:   201.8°C

       Density:  1.0341 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:   2.35
                                      CHEMICAL  NAME
                                         Physical State:  Solid

                                         Vapor Density:  3.72

                                         Melting Point:   35.26°C

                                         Solubility:   Slightly (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:  Fire-moderate
                   Explosion-moderate
                   Disaster hazard-dangerous-toxic fumes
                                              AI-300

-------
                                                                                  p-Cresol
                                PRODUCTION DATA

Annual U.S.
 Production:   31.4x10 Ibs. (1973) (p and m cresol)  Consumption:
Fraction of
  Dispersion:

Release Rate (million Ibs/yr):
Fraction of Pro-
  duction Lost:  0.015
                                  TOXICITY DATA
Acute Toxicity
     LD50
      LDLo
 Animal
rat
rat
mouse
rabbit
mouse
cat
rabbit
rabbit
rabbit
guinea pig
frog
 Dosage
207 mg/kg
750 mg/kg
344 mg/kg
301 mg/kg
150 mg/kg
 80 mg/kg
620 mg/kg
300 mg/kg
180 mg/kg
100 mg/kg
150 mg/kg
Non-lethal Acute Effects:
      Corrosive to skin and mucous membranes
      Damage to kidney, liver, nervous system
      Dermatitis
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 5 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:  TDLo 5500 mg/kg pregnant rat oral TLV:  5j>pm

   Other Chronic Effects:
  Route
oral
skin
oral
skin
subcutaneous
subcutaneous
oral
subcutaneous
intravenous
intraperitoneal
subcutaneous
                                         AI-301

-------
                                  CHEMICAL  NAME
CAS Number:   123-73-9

Chemical Name:   (E>Crotonaldehyde

Synonyms:   2-Butenal
            Ciotonic aldehyde
            0-Methyl acrolein
Molecular
  (Formula:   C4H6O
Structure:    CH3 - CH = CH - C
                                     0
                                     H
Chemical Properties

   Molecular Weight:  70.09

   Vapor Pressure:  10 mm at 25°C

   Bojling Point:   104°C

   Density:  0.853 at 20°C/20°C

   Octanol/Water Parti-
     tion Coefficient:
Physical State:  Liquid

Vapor Density: 2.41

Melting Point:  -69°C

Solubility:  Soluble (H2O)
Environmental Persistence

   BOD:    27% of theoretical at 10 days

   Atmospheric Reactivity:.  Reacts with oxidizing materials
Safety Hazard:
                                          AI-302

-------
                                                                    Crotonaldehyde
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rats (million Ibs/yr):
                               PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                       duction Lost:
Acute Toxicity
      LDSO
      LCSO
        TOXICITY DATA

  Dosage               Animal
 300 mg/kg             rat
 140mg/kg  .           rat
   6 mg/kg             mouse
 160 mg/kg             mouse
  30                  guinea pig
4000 mg/m3 (30 minutes) rat
1510mg/m3 (2 hours)    mouse
 Non-lethal Acute Effects:
      Irritant- TCLo         4 ppm
             Dangerous to eyes
             Causes cornea! burns, irritant to skin
                      human
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 2 ppm



   Carcinogenicity: Not tested


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:  2ppm
  Route
oral
subcutaneous
oral
subcutaneous
skin  '
inhalation
inhalation
                                         inhalation
                                       AI-303

-------
Crotonic  acid
                                      CHEMICAL  NAME
    CAS Number:   324-65-0

    Chemical Name:   Crotonic acid

    Synonyms:  g-Methyl acrylic acid
                Trans-2-butenoic acid
                Methyl-propenoic acid
    Molecular
      Formula:  C4H6O2
                                     o

    Structure:   CH3CH = CH  - C
                                   \
               	OH



    Chemical Properties

        Molecular Weight:   86.09                        Physical State:  Solid

        Vapor Pressure:  0.19 mm at 20°C                 Vapor Density:  2.97

        Boiling Point:   185°C                          Melting Point:   72°C

        Density:  1.018 at 15°C/4°C                      Solubility:   Soluble (H2O)

        Octanol/Water Parti-
         tion Coefficient:   0.76

    Environmental Persistence

        BOD:

        Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:  Fire-slight
                                              AI-304

-------
                                                                      Crotonic acid
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LD50               1000mg/kg            rat                 oral
                         600 mg/kg            guinea pig           skin
Chronic Toxicity

   U.S. Occupational Standard:




   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-305.

-------
Cumene


                                     CHEMICAL NAME


    CAS Number:  98-82-8

    Chemical Name:   Cumene

    Synonyms:   Isopiopyl benzene
                2-Phenyl propane
                Cumol
    Molecular
      Formula:   C9HU
    Structure:
                                CH3
                                CH3
     Chemical Properties

       Molecular Weight:  120.21                      Physical State:  Liquid

       Vapor Pressure: 6.56at25°C                    Vapor Density:  4.1

       Boiling Point:   152°C                          Melting Point:  -96°C

       Density:    °-864 at 20°C/4°C                  Solubility:  Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:    70% of theoretical foi 20 days at 20°C
                Total theoretical oxygen demand gm/gm = 3.5  •
       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard: Fire-moderate
                                             AI-306

-------
                                                                                Cumene

                               PRODUCTION DATA
Annual U.S.
 Production:   2292.9 x 106 Ibs.                   Consumption:  2737.2 x 106 Ibs.
Fraction of                                     Fraction of Pro-
 Dispersion:    0.0.1                               duction Lost: 0.01
Release Rate (million Ibs/yr):  50.3

                                 TOXICITY DATA
Acute Toxicity               Dosage               Animal               Route
      LDSo               1400mg/kg            rat                 oral
                         8000 ppm             lat                 inhalation
                         2000 ppm             mouse              inhalation
Non-lethal Acute Effects:
          Potent narcotic effects ;
          Depressant to CNS
          Dermatitis
Chronic Toxicity
   U.S. Occupational Standard:   (air): TWA 50 ppm

   Carcinogenicity:

   Mutagenicity:
   Teratogenicity:                                TLV:
   Other Chronic Effects:
                                       AI-307

-------
Cumene  hydroperoxide
                                     CHEMICAL  NAME


    CAS Number:    80-15-9

    Chemical Name:    a,a-Dimethyl benzyl hydroperoxide

    Synonyms:   Caruacrol                                    2-Hydro-p-cumene
                o-Cresyl-5-isopropyl

    Molecular
      Formula:   c9H12O2


                          OH

               CH3
    Structure:    ^--_
                   JLC

               CH3
     Chemical Properties

       Molecular Weight:   152.21                      Physical State:   Liquid

       Vapor Pressure:  lmmat70°C                   Vapor Density:

       Boiling Point:    153°C                         Melting Point:

       Density:   1.05                                Solubility:   Slightly soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:    Explosion-dangerous
                                             AI-308

-------
                                                             Cumene hydroperoxide
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
      LD50
      LDLo


      LCSO
 382 mg/kg
  95 mg/kg
 400 mg/kg

5000 mg/kg
  90 mg/kg

 220 ppm (4 hours)
 200 ppm (4 hours)
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
       Neoplastic effects:
       TDLo


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
       Skin sensitizer
Animal
rat
rat
rat

mouse
mouse

rat
mouse
 304 mg/kg              mouse
  10 gm/kg (76 weeks)    mouse
                      TLV:
 Route
oral
intraperitoneal
subcutaneous

oral
intraperitoneal

inhalation
inhalation
                   inhalation
                   subcutaneous
                                       AI-309

-------
Cyanoacetic acid
                                     CHEMICAL  NAME
    CAS Number:   372-09-8

    Chemical Name: Cyanoacetic acid

    Synonyms:  Malonic acid, mononitrile
    Molecular
      Formula:   C3H3NO2
    Structure:   N = C - CH2 - COOH
     Chemical Properties

       Molecular Weight:  85.06

       Vapor Pressure:

       Boiling Point:    108°C at 15 mm

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
Physical State:  Solid

Vapor Density:

Melting Point:   66.1 to 66.4°C

Solubility:    Soluble (H2O)
                                             AI-310

-------
                                                                   Cyanoacetic acid
                              PRODUCTION DATA

Annual U.S.
 Production:    200 x 106 Ibs. (1967)              Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:  0.01                                duction Lost:  0.015

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LD50              200 mg/kg             mouse              intrapetitoneal

      Very toxic
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AI-311

-------
Cyanogen chloride
                                     CHEMICAL  NAME
    CAS Number:    506-77-4

    Chemical Name:    Cyanogen chloride

    Synonyms:   Chlorine cyanide
                CK

    Molecular
      Formula:   CC1N
    Structure:
     Chemical Properties

       Molecular Weight:  61.48

       Vapor Pressure:  1010 mm at 20°C

       Boiling Point:    13.1°C

       Density:  1.218 at 4°C/4°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
Physical State:  Liquid

Vapor Density:  2.1

Melting Point:  -6.5°C

Solubility:    Soluble (H2O)
                                            AI-312

-------
                                                                    Cyanogen chloride
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                        duction Lost:
Acute Toxicity
       LDLO
       LDSO
         TOXICITY DATA

  Dosage               Animal
 39 mg/kg              mouse
  5 mg/kg              dog
 20 mg/kg              rabbit

118 ppm (30 minutes)     rat
177 ppm (30 minutes)     mouse
207 ppm (30 minutes)     rabbit

207 ppm (30 minutes)     guinea pig
 Non-lethal Acute Effects:
       Irritant to eyes and mucous membranes
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
 Route
subcutaneous
subcutaneous
subcutaneous

inhalation
inhalation
inhalation

inhalation
                                        AI-313

-------
©yanisriis acid
                                      CHEMICAL  NAME
    CAS Number:   108-80-5

    Chemical Name:   s-Triazine -2,4,6-triol
Synonyms:   sym-Triazinetriol
            Tricyanic acid

Molecular
  Formula:   C,H,N,O,
                                    Cyanuric acid, dihydrate
                                    Tricaibimide
                  HO
    Structure:
                   C
                   I
                   N
\   OH
 c'
                          N
                             /
                          C
                           I
                          OH
     Chemical Properties   (dihydrate)

       Molecular Weight:   165.11

       Vapor Pressure:

       Boiling Point:  decomposes

       Density:   1.768 at 0°C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:  Disaster hazard- cyanides
                                                 Physical State:

                                                 Vapor Density:

                                                 Melting Point:  320 to 350°C (decomposes)

                                                 Solubility:   Soluble (H2O)
                                              AI-314

-------
                                                                       Cyanuric  acid
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal               Route
      Highly toxic
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI-315

-------
Cyanuric chloride
                                      CHEMICAL NAME
     CAS Number:   108-77-0

     Chemical Name:    2,4,6 Trichloros-triazine

     Synonyms:  Cyanuric chloride


     Molecular
      Formula:  C3C13N3

                        Cl
                         I
                        C
     Structure:.
N
 I
C
                ci
 N
 II
 C
   \
'   a
                        N
     Chemical Properties

        Molecular Weight:   184.42

        Vapor Pressure:  2 mm at 70°C

        Boiling Point:   190°C

        Density:   1.32 at 20°C/4°C

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
     Safety Hazard:   Disaster hazard-dangerous-chlorides and nitriles
                           Physical State:   Solid

                           Vapor Density:  6.36

                           Melting Point:   154°C

                           Solubility:   Insoluble (H2O)
                                              AI-316

-------
                                                                     Cyanuric chloride
                               PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
      LD5o               485 mg/kg              rat                 oral

 Non-lethal Acute Effects:
      Irritation of mucous membranes
      Disturbed heart rhythm
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:  Neoplastic effects
       TDLo                22 gm/kg (82 weeks)    rat                 oral
                          750 mg/kg (15 weeks)    rat                 subcutaneous
   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                        AI-317

-------
Cyclohexane
                                     CHEMICAL  NAME
    CAS Number:    110-82-7

    Chemical Name:    Cyclohexane

    Synonyms:  Hexahydrobenzene
               Hexanapthene
               Hexamethylene
    Molecular
      Formula:  C6H12
    Structure:
    Chemical Properties

       Molecular Weight:  84.16

       Vapor Pressure:  98.14 at 25°C

       Boiling Point:    80.7°C

       Density:  0.77855 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:
Physical State:  Liquid

Vapor Density:  2.90

Melting Point:  6.3°C

Solubility:   Insoluble (H2O) «1 gm/1)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fire-dangerous
                   Explosion-moderate
                                             AI-318

-------
                                                                         Cyclohexane


                               PRODUCTION DATA
Annual U.S.
 Production:   416 x 106 Ibs. (1976 capacity)         Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:   0.10                               duction Lost: 0.015

Release Rate (million Ibs/yr): 94.2 (1972)
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
     LDso               1297 mg/kg             mouse              oral
                        5500 mg/kg             rabbit              oral
     I.DLO                77 mg/kg             rabbit              intravenous
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 300 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV: 300 ppm

   Other Chronic Effects:    Skin irritation
                         May be an asphyxiant
                                        AI-319

-------
Cyclohexanol
                                     CHEMICAL  NAME
    CAS Number:   108-93-0

    Chemical Name:   Cyclohexanol

    Synonyms:  Hexahydrophenol
               Hexalin

    Molecular
      Formula:  C6H12O
    Structure:    /   VOH
    Chemical Properties

       Molecular Weight:  100.17

       Vapor Pressure: 1.7 mm at 25°C

       Boiling Point:   161.5°C

       Density: 0.9449 at 25°C/4°C

       Octanol/Water Parti-
         tion Coefficient:
Physical State: Liquid

Vapor Density: 3.45

Melting Point:  23°C

Solubility:   Soluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:  Fire-moderate
                                             AI-320

-------
                                                                          Cyclohexanol
Annual U.S.
 Production:   760 x 106 Ibs.

Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:
                      Fraction of Pro-
                       duction Lost:  0.007
                                  TOXICITY DATA
Acute Toxicity
      LD50
  Dosage
2060 mg/kg
1300mg/kg
 800 mg/kg
2200 mg/kg
1420 mg/kg
Non-lethal Acute Effects:
      Mucous membrane effect: TCLC,  100 ppm
      Conjunctivitis
      Corneal necrosis
      Irritation of skin and respiratory tract
 Animal
rat
dog
cat
rabbit
rabbit
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 50 ppm



   Carcinogenicity: Not tested


   Mutagenicity:

   Teratogenicity:                                TLV: 50 ppm

   Other Chronic Effects:    Damage to kidneys, liver, blood vessels
  Route
oral
oral
subcutaneous
oral
intraperitoneal
                                        AI-321

-------
Cyclohexanone
                                     CHEMICAL  NAME
    CAS Number:   108-94-1

    Chemical Name:    Cyclohexanone

    Synonyms:   Ketohexamethylene
                Pimelic ketone
                Hexanon
    Molecular
      Formula:   C6H10O
Cyclohexylketone
    Structure:
                                o
                  XCH2 -  C^
                                  CH-,
                     CH2 - CH2
     Chemical Properties

       Molecular Weight:  98.14

       Vapor Pressure:  4.77 mm at 25°C

       Boiling Point:    155,6°C

       Density:  0.9478 at 20°C/4°C

       Octanol/Water Parti-
         tion Coefficient:  0.01
        Physical State:  Liquid

        Vapor Density: 3.4

        Melting Point:  -47°C

        Solubility:   50 gm/1 (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   Fire-moderate
                   Explosion-slight
                                             AI-322

-------
                                                                      Cyclohexanone
                               PRODUCTION DATA
Annual U.S.
 Production:

Fraction of
 Dispersion:
784.4 x 10" Ibs.
0.05
Consumption:  784.4

Fraction of Pro-
 duction Lost: °-015
Release Rate (million Ibs/yr): 51.0
                                 TOXICITY DATA
Acute Toxicity
     LD50
             Dosage
           1620 mg/kg
           1350mg/kg
           1000 mg/kg
           1300 mg/kg
            630 mg/kg
           1600 mg/kg
           2000 ppm (4 hours)
Non-lethal Acute Effects:
      Irritant: eyes and throat
        TCLo              50 ppm
 Animal
rat
mouse
rabbit
mouse
dog
rabbit
rat
                                 human
  Route
oral
intraperitoneal
skin
oral
intravenous
oral
inhalation
                   inhalation
Chronic Toxicity

   U .8. Occupational Standard:  (air) TWA 50 ppm


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                 TLV: 50 ppm
                                        AI-323

-------
Cyclohexene
                                     CHEMICAL NAME
    CAS Number:    110-83-8

    Chemical Name:    Cyclohexene

    Synonyms:   1,2,3,4-Te trahy drobenzene
    Molecular
      Formula:   C6H10
    Structure:
     Chemical Properties

       Molecular Weight:  82.14                       Physical State:  Liquid

       Vapor Pressure:  160 mm at 38°C                 Vapor Density: 2.8

       Boiling Point:    83°C at 760°C                  Melting Point:  -103.7

       Density:  0.8102 at 20°C/4°C                    Solubility:   Insoluble (H2O).

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fire-dangerous
                                             AI-324

-------
                                                                      Cyclohexene
                              PRODUCTION DATA

Annual U.S.
 Production:   2298.4 x 106 Ibs.                  Consumption:  1779.4

Fraction of                                   Fraction of Pro-
 Dispersion:   0.04                              duction Lost: 0.01

Release Rate (million Ibs/yr):  94.2
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 300 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                       AI-325

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Cyclohexylamine
                                     CHEMICAL  NAME
    CAS Number:   108-91-8

    Chemical Name:    Cyclohexylamine

    Synonyms:  Hexahydroaniline
               Aminocyclohexane

    Molecular
      Formula:  C6H13N
    Structure:    (     ANH2
     Chemical Properties

       Molecular Weight:  99.2                         Physical State:  Liquid

       Vapor Pressure:                                Vapor Density: 3.42

       Boiling Point:   134.5°C                        Melting Point:  -18°C

       Density:  0.865 at 25°C/25°C                    Solubility:   Soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fire-moderate
                  Disaster hazard-dangerous-toxic fumes
                                             AI-326

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                                                                   Cyclohexylamine
                               PRODUCTION DATA
Annual U.S.
 Production:   12 x 106 Ibs. (1967)

Fraction of
 Dispersion:   0.01  .

Release Rate (million Ibs/yr):
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                0.015
                                 TOXICITY  DATA
Acute Toxicity
     LD50
 710 mg/kg
 200 mg/kg
 300 mg/kg
 120 mg/kg
 500 mg/kg
8000 ppm (4 hours)
Chronic Toxicity.

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Dermatitis
Convulsions
CNS depression
 Animal
rat
rat
mouse
rabbit
rabbit
rat
  Route
oral
intrapeiitoneal
intraperitoneai
skin
parenteral
inhalation
                      TLV: 10 ppm
                                       AI-327

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Cyclopentadiene
                                     CHEMICAL NAME
    CAS Number:   542-92-7

    Chemical Name: 1,3-Cyclopentadiene

    Synonyms:
    Molecular
      Formula:   CSH6
    Structure:
\\  //
    Chemical Properties

       Molecular Weight:  66.11

       Vapor Pressure:  10mmat25°C

       Boiling Point:   40.0°C at 760 mm

       Density:  0.80475 at 19°C/4°C

       Octanol/Water Parti-
         tion Coefficient:
                                  Physical State:

                                  Vapor Density:

                                  Melting Point: .-97.2°C_

                                  Solubility:   Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   Fire-moderate
                   Explosion -moderate
                                            AI-328

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                                                                 Cyclopentadiene
                              PRODUCTION DATA

Annual U.S.
 Production:    100 x 106 Ibs. (Total capacity)        Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion: 0.01                                duction Lost:  0.015

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
   TDLo                 250 ppm             human       .       inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 75 ppm




   Carcinogenicity:  Not tested


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:     Abdominal pain
                         Jaundice
                         Anemia
                                      AI-329

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Cyprex


                                     CHEMICAL NAME


    CAS Number:    2439-10-3

    Chemical Name:     Dodecylguanidine, monoacetate

    Synonyms:   Cyprex
                Dodine

    Molecular
      Formula:
    Structure:    n - C12H25 - N - C	•  CH3COOH
                              H     \      	
               	   NH2
    Chemical Properties

       Molecular Weight:   287.36                      Physical State:  Solid

       Vapor Pressure:                                Vapor Density:

       Boiling Point:                                  Melting Point:  136°C

       Density:                                      Solubility:   Soluble (hot H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                              AI-330

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                                                                                  Cyprex



                               PRODUCTION DATA

Annual U.S.
 Production:    2.0 x 106 Ibs.                      Consumption:   2.0 x 106 Ibs.

Fraction of                                      Fraction of Pro-
 Dispersion:  1.0                                 duction Lost:  0.01

Release Rate (million Ibs/yr):  2.0



                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LD50              566 mg/kg             rat                 oral
                         1000 mg/kg             rat                 unknown
Chronic Toxicity

   U.S. Occupational Standard:




   Carcinogenicity:



   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
        Strong solutions cause severe irritation of skin and eyes
                                        AI-331

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                                   TECHNICAL REPORT DATA
                            (Please read Instructions on the reverse before completing)
1. REPORT NO.
 EPA-450/3-77-008b
                                                        3. RECIPIENT'S ACCESSIOWNO.
              Scoring of Organic Air Pollutants:
Chemistry,  Production and Toxicity of Selected
Synthetic Organic Chemicals
(Chemicals  A-C) Appendix  I	
                                                            5. REPORT DATE
                                                                  October 1976         '
                                                            6. PERFORMING ORGANIZATION CODE
7. AUTHOR(S)
                                                            8. PERFORMING ORGANIZATION REPORT NO.
    J.  Dorigan, B. Fuller,  R.  Duffy
9. PERFORMING ORGANIZATION NAME AND ADDRESS
      The  Mitre Corporation
     Metrek Division
     Westgate Research Park
     McLean, Virginia  22101
                                                            10. PROGRAM ELEMENT NO.
                                                        11. CONTRACT/GRANT NO.
                                                              68-02-1495
12. SPONSORING AGENCY NAME AND ADDRESS
     EPA,  Office of Air  Quality Planning  and Standards
     Strategies and Air  Standards Division
     Research Triangle Park, N.C.  27711
                                                            13. TYPE OF REPORT AND PERIOD COVERED
                                                        14. SPONSORING AGENCY CODE
15. SUPPLEMENTARY NOTES
16. ABSTRACT
          This is the  first of a series  of four appendices to the report  "Scoring
     of Organic Air  Pollutants."  The  entire appendix  contains a compilation of
     available data  on chemical structure and properties,  environmental  persistence,
     production, and toxicity for 637  synthetic organic chemicals.
17.
                                KEY WORDS AND DOCUMENT ANALYSIS
                  DESCRIPTORS
                                          b.lDENTIFIERS/OPEN ENDED TERMS  C. COS AT I Field/Group
     organic chemical
     organic chemical
     organic chemical
     organic chemical
                   structure
                   properties
                   production
                   toxicity
18. DISTRIBUTION STATEMENT
                                               19. SECURITY CLASS (ThisReport)
                                                  unclassified
                                                                      21. NO. OF PAGES

                                                                               338
     unlimited
                                          20. SECURITY CLASS (Thispage)
                                             unclassifieo!
                                                                          22. PRICE
EPA Form 2220-1 (9-73)

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