-------
Dicofol
Annual U.S.
Production:
4.0 x 10° Ibs.
Fraction of
Dispersion: Estimated as 1.0
Release Rate (million Ibs/yr): 4.0
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
0.015
Acute Toxicity
LDSO
TOXICITY DATA
Dosage
575 mg/kg
100 mg/kg
1150 mg/kg
1810 mg/kg
1870 mg/kg
Animal
rat
rat
rat
rabbit
rabbit
Route
oral
skin
intraperitoneal
intraperitoneal
skin
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
All-67
-------
Dicumyl peroxide
CHEMICAL NAME
CAS Number: 80-43-3
Chemical Name: Bis(a,o!-dimethylbenzyl)peroxide
Synonyms: Cumine peroxide
Isopiopylbenzene peroxide
Dicumyl peroxide
Molecular
Formula:
CH3 CH3
Structure: / Vc-O-O-C^/ )>
\=/ I I \=/
CH3 CH3
Chemical Properties
Molecular Weight: 270.40
. Vapor Pressure: Negligible
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-may ignite organic materials on contact
Physical State: Solid
Vapor Density:
Melting Point:
Solubility:
AII-68
-------
Dicumyl peroxide
PRODUCTION DATA
Annual U.S.
Production: 15 x 106 Ibs. Consumption: 15 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 1 -0 duction Lost: 0.02
Release Rate (million Ibs/yr): 15.3
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSo 4100mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-69
-------
Dicyclohexylamine
CHEMICAL NAME
CAS Number: 101-83-7
Chemical Name: Dicyclohexylamine
Synonyms:
Molecular
Formula:
H
/—\ ' /—\
Structure: / / N \ )
Chemical Properties
Molecular Weight: 181.32 Physical State: Liquid
Vapor Pressure: <10 mm at 25°C Vapor Density: 6.27
Boiling Point: 256°C Melting Point: -0.10°C
Density: 0.9123 at 20°C/4°C Solubility: Slightly soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-70
-------
Dicyclohexylamine
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITYDATA
Acute Toxicity Dosage Animal Route
LD50 373 mg/kg rat , oral
500 mg/kg ; mouse oral
Non-lethal Acute Effects:
Irritant-local irritation and nervous system excitation
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Neoplastic effects:
TD, 2400 mg/kg mouse subcutaneous
(48 week continuous)
Teratogenicity: TLV:
Other Chronic Effects:
AII-71
-------
Dieldrin
CHEMICAL NAME
CAS Number:
60-57-1
Chemical Name: 1,2,3,4,10,10-Hexachloro-6,7-epoxy-l ,4,4a,5,6,7,8,8a-octahydro-l,4,5,8-dimethano-
naphthalene
Synonyms: Compound 497
Molecular
Formula:
Structure:
a
a
Chemical Properties
Molecular Weight: 381
Vapor Pressure: 1.78 x 10~7 mmat20°C
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient: 4.56
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Disaster hazard—dangerous, toxic fumes, chloride
Physical State:
Vapor Density:
Melting Point:
Solubility:
Solid
176tol77°C
Insoluble (0.186 mg/!H2O
at 25 to 29° Q
AII-72
-------
Dieldrin
Annual U.S.
Production:
Fraction of
Dispersion:
106 Ibs.
PRODUCTION DATA
Consumption:
Estimated as 1 .0
Release Rate (million Ibs/yr):
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LDSO
Non-lethal Acute Effects:
CNS stimulant
TOXICITY DATA
Dosage Animal
46 mg/kg rat
60 mg/kg rat (female)
90 mg/kg rat (male)
10.5 mg/kg mouse
400 mg/kg rabbit
27 mg/kg pigeon
20 mg/kg chicken
Route
oral
skin
skin
intravenous
skin
oral
oral
Chronic Toxicity
U.S. Occupational Standard:
J^arcinogenicity:
Neoplastic effects:
TDLo
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
730 mg/kg (52 weeks)
1800 mg/kg (2 years)
mouse
rat
oral
oral
TLV: 100gm/m3(skin)
All-73
-------
Diethanolamine
CHEMICAL NAME
CAS Number: 111-42-2
Chemical Name: 2,2' Iminodiethanol
Synonyms: DBA Diethylolamine
Pi (2-hydroxyethyl)-amine Diolamine
Bis-hydroxyethylamine Diethanolamine
Molecular
Formula: C4HnNO2
NH
/ \
Structure: HO - CH2 - CH2 CH2 - CH2 - OH
Chemical Properties
Molecular Weight: 105.14 Physical State: Liquid
Vapor Pressure: 5 mm at 138°C Vapor Density: 3.65
Boiling Point: 269.1°C Melting Point: 28.0
Density: 1.0919 at 30°C/20°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient: -2.02
Environmental Persistence
BOD: 88% of total theoretical after 20 days at 20°C
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-slight
AII-74
-------
Diethanolamine
PRODUCTION DATA
Annual U.S.
Production: 101.1 x 106 Ibs. Consumption: 86.1 x 106 Ibs.
Fraction of
Dispersion: 0.40
Release Rate (million Ibs/yr): 36.0
Fraction of Pro-
duction Lost: 0.015
TOXiCITY DATA
Acute Toxicity
LDso
Non-lethal Acute Effects:
Dosage
710mg/kg
2300 mg/kg
3553 mg/kg
Irritation of skin and mucous membranes
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
mouse
mouse
TLV:
Route
oral
intraperitoneal
subcutaneous
AII-75
-------
Diethylamine
CHEMICAL NAME
CAS Number: 109-89-7
Chemical Name: Diethylamine
Synonyms: Diethamine
Molecular
Formula: C4H, tN
NH
Structure: C2HS
CH
25
Chemical Properties
Molecular Weight: 73.1
Vapor Pressure: 247.1 at 25°C
Boiling Point: 55.5°C
Density: 0.7108at20°C/20°C
Octanol/Water Parti-
tion Coefficient: 0.82
Physical State: Liquid
Vapor Density: 2.53
Melting Point: -49.8°C
Solubility: Very soluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-dangerous
All-76
-------
Diethylamine
PRODUCTION DATA
8.8xlO°lbs.(1970)
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Consumption:
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
LCSo
540 mg/kg
649 mg/kg
820 mg/kg
4000 ppm (4 hours)
Animal
rat
mouse
rabbit
rat
Route
oral
oral
skin
inhalation
Non-lethal Acute Effects:
Irritant to skin and mucous membranes
Liver damage
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 25 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 25 ppm
Other Chronic Effects: Extremely dangerous if ingested
AII-77
-------
Diethylaminoethanol
CHEMICAL NAME
CAS Number: 100-37-8
Chemical Name: 2-(Diethylamino) ethanol
Synonyms: Diethylethanolamine
Diethylaminoethanol
Molecular
Formula: C6H1SNO
Structure: CH3CH2 - N
CH2tH2OH
CH2CH3
Chemical Properties
Molecular Weight: 117.2
Vapor Pressure: 21 mm at 20°C
Boiling Point: 163°Cat760mm
Density: 0.8921 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 0.46
Physical State: Liquid
Vapor Density: 4.03
Melting Point: -70°C
Solubility: Infinite (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-78
-------
Diethylaminoethanol
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity Dosage
LDSO 1300mg/kg
1220 mg/kg
1561 mg/kg
1260 mg/kg
Non-lethal Acute Effects:
Central nervous system
TCLO 200 ppm
Irritant to skin and mucous membranes
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 10 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
rat
mouse
rabbit
human
Route
oral
intiaperitoneal
subcutaneous
skin
inhalation
TLV: 10ppm
All-79
-------
Diethylene glycol
CHEMICAL NAME
CAS Number: 111-46-6
Chemical Name: Diethylene glycol
Synonyms: Diglycol Ethylenediglycol
Bis (2-hydroxylethyl) ether 3-Oxa-l,5-pentanediol
2,2'-Oxydiethanol
Molecular
Formula: C4H10O3
Structure: HO - CH2 - CH2 - O - CH2 - CH2 - OH
Chemical Properties
Molecular Weight: 106.12 Physical State: Liquid
Vapor Pressure: lmmat91.8°C Vapor Density: 3.66
Boiling Point: 245°C at 760 mm Melting Point: -10.5°C
Density: 1.1184at20°C/20°C Solubility: Soluble (H2b)
Octanol/Water Parti-
tion Coefficient: 1.98
Environmental Persistence
BOD: 67% of theoretical
Total theoretical oxygen demand = 1.5(gm/gm)
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-slight
All-80
-------
Diethylene glycol
PRODUCTION DATA
Annual U.S.
Production: 350 x 10* Ibs.
Fraction of
Dispersion: 0.28
Release Rate (million Ibs/yr): 93.4
Consumption: 315 x 10 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
Non-lethal Acute Effects:
Pulmonary edema
Nausea and vomiting
Coma
Dosage
1000 mg/kg
9000 mg/kg
3300 mg/kg
2000 mg/kg
Animal
human
dog
cat
rabbit
Route
oral
oral
oral
intravenous
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AII-81
-------
Diethylene glycol, dibutyl ether
CHEMICAL NAME
CAS Number: 112-73-2
Chemical Name: Bis-(2-butoxyethyl) ether
Synonyms: Bis(a-chloroethyl)ether
DiethyTene glycol dibutyl ether
Molecular
Formula: C12"26O3
Structure: C4H9 - O - CH2 - O - C4H9
Chemical Properties
Molecular Weight: 218
Vapor Pressure: 0.02 mm at 20°C
Boiling Point: 2S6°C
Density: 0.8853 at 20°C/20°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
- BOD:
Atmospheric Reactivity:
Safety Hazard: Fire-slight
Physical State: Liquid
Vapor Density:
Melting Point: -60.2°c
Solubility: Slightly (H2O)
All-82
-------
Diethylene glycol, dibutyl ether
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 3900 mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: Not tested
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-83
-------
Diethylene glycol, diethyl ether
CHEMICAL NAME
CAS Number: 112-36-7
Chemical Name: Bis(2-ethoxyethyl) ether
Synonyms: Diethylene glycol diethyl ether
Molecular
Formula: C8H18O3
Structure: C2H5 - 0 - CH2 - O - CH2 - CH2 - O - C2H5
Chemical Properties
Molecular Weight: 162.26 Physical State: Liquid
Vapor Pressure: <10 mm at 25°C Vapor Density: 5.6
Boiling Point: 189°C Melting Point: -44.3°C
Density: 0.9082 at 20°C/20°C Solubility: Very soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Fire-moderate
AII-84
-------
Diethylene glycol, diethyl ether
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 1850mg/kg guinea pig oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: Not tested
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AH-85
-------
Diethylene glycol, dimethyl ether
CHEMICAL NAME
CAS Number: 111-96-6
Chemical Name: l,l'-Oxybis[2-methoxyethane]
Synonyms: ~ Bis(2-methoxyetnyl)ether
Dimethylcarbitol
Diglyme
Molecular
Formula: C6H12O3
Structure: CH3 - O - CH2CH2 - 0 - CH2CH2 - O - CH3
Chemical Properties
Molecular Weight: Physical State: Liquid
Vapor Pressure: Vapor Density:
Boiling Point: 162.0°C Melting Point: -68.0°C
Density: 0.9451 at 20°C/20°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AII-86
-------
Diethylene glycol, dimethyl ether
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: Not tested
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-87
-------
Diethylene glycol, monobutyl ether
CHEMICAL NAME
CAS Number: 18912-80-6
Chemical Name: 2-(2-Isobutoxyethoxy) ethanol
Synonyms: Butyl carbitol Diethylene glycol n-butyl ether
Butoxy diglycol Diglycol monobutyl ether
Obutyldiethyleneglycol Diethylene glycol monobutyl ether
Molecular
Formula: CgH18O3
Structure: HO - CH2 - CH2 - O - CH2CH2 - O - CH2 - CH2 - CH2 - CH3
Chemical Properties
Molecular Weight: 162.2 Physical State: Liquid
Vapor Pressure: 0.01 mm at 20°C Vapor Density: 5-58
Boiling Point: 230.6°C Melting Point: -68.1°C
Density: 0.9536at20°C/20°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-88
-------
Diethylene glycol, monobutyl ether
PRODUCTION DATA
Annual U.S.
Production: 41.2xl06lbs.
Fraction of
Dispersion: 0.90
Release Rate (million Ibs/yr): 68.6
Consumption: 40.2 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
Dosage
850 mg/kg
2000 mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogeriicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
mouse
guinea pig
Route
intraperitoneal
oral
TLV:
AII-89
-------
Diethylene glycol, monobutyl ether acetate
CHEMICAL NAME
CAS Number: 112-17-4
Chemical Name: Acetic acid, decyl ester
Synonyms: Butyl "caibitol" acetate
Diethylene glycol monobutyl ether acetate
Molecular
Formula: C10H2()O4
O
Structure: CH3(CH2)3 - O - (CH2)2 - O - (CH2>2 T O - C
~'3
\
CH,
Chemical Properties
Molecular Weight: 204.26 Physical State: Liquid
Vapor Pressure: <0.01 mm at 20°C Vapor Density:
Boiling Point: 246.7°C at 760 mm Melting Point: -32.2°C
Density: 0.981 at 20°C/20°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-90
-------
Diethylene glycol, monobutyl ether acetate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXIC ITY DATA
Acute Toxicity Dosage Animal Route
LD50 2600 mg/kg rabbit oral
2340 mg/kg guinea pig oral
5000 mg/kg chicken oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogen icity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-91
-------
Diethylene glycol, monethyl ether
CHEMICAL NAME
CAS Number: 111-90-0
Chemical Name: 2-(2-Ethoxyethoxy)ethanol
Synonyms: Diethylene glycol monoethylethet Diglycolmonoethyl ether
Carbitol_ Ethylene diglycol monoethyl ether
Diethylene glycol, ethyl ether Cellosolve
Molecular Ethoxydiglycol
Formula: C6H14O3
Structure: CH3CH2 - O - CH2CH2 - O - CH2CH2OH
Chemical Properties
Molecular Weight: 134.17 Physical State: Liquid
Vapor Pressure: <1.0 mmat 20°C Vapor Density: 4.62
Boiling Point: 201.9°C Melting Point:
Density: 0.9902 at 20°C/4°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient: -0.93
Environmental Persistence
BOD: 87% of theoretical after 20 days at 10°C
Total theoretical oxygen demand =1.9 (gm/gm)
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-moderate
AII-92
-------
Diethylene glycol, monethyl ether
PRODUCTION DATA
Annual U.S.
Production: 24.8 x 106 Ibs.
Fraction of
Dispersion: 1.0
Release Rate (million Ibs/yr): 36.8
Consumption: 24.8 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
LDLo
Dosage
2900 mg/kg
5638 mg/kg
3900 mg/kg
3000 mg/kg
3620 mg/kg
2000 mg/kg
900 mg/kg
3070 mg/kg
2000 mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
mouse
mouse
dog
rabbit
rabbit
rabbit
guinea pig
rat
Route
intravenous
subcutaneous
intravenous
intravenous
oral
subcutaneous
subcutaneous
oral
subcutaneous
TLV:
AII-93
-------
Diethylene glycol, monoethyl ether acetate
CHEMICAL NAME
CAS Number: 112-15-2
Chemical Name: 2-(2-Ethoxyethoxy) ethanol acetate
Synonyms: Caibitol acetate
Diethylene glycol monoethyl ether acetate
Molecular
Formula: C8H16O4
O
Structure: CH3CH2 - O - CH2CH2 - O - CH2 - CH2 — O — C
\
CH3
Chemical Properties
Molecular Weight: 176.21 Physical State: Liquid
Vapor Pressure: 0.05mmat20°C Vapor Density: 6-07
Boiling Point: 217.4°C Melting Point: -25°C
Density: 1.0114 at 20°C/20°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire—moderate
AII-94
-------
Diethylene glycol, monoethyl ether acetate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
3930 mg/kg guinea pig oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: Not tested
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-95
-------
Diethylene glycol, monohexyl ether
CHEMICAL NAME
CAS Number: 112-59-4
Chemical Name: 2-[2-(Hexyloxy)ethoxy] ethanol
Synonyms: Hexyl carbitol
Diethylene glycol monohexyl ether
Molecular
Formula: C10H22O3
Structure: CH3 - (CH2)5 - O - (CH2) - O - CH3 - CH2 - OH
Chemical Properties
Molecular Weight: 190.32 Physical State: Liquid
Vapor Pressure: 0.01 mm at 20°C Vapor Density:
Boiling Point: 258.2°C Melting Point: -33°C
Density: 0.9346 at 20°C/20°C Solubility:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
.Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-slight
All-96
-------
Diethylene glycol, monohexyl ether
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 2920 mg/kg rat oral
1500 mg/kg rabbit skin
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: Not tested
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-97
-------
Diethylene glycol, monomethyl ether
CHEMICAL NAME
CAS Number: 111-77-3
Chemical Name: 2-(2-Methoxyethoxy) ethanol
Synonyms: Methyl caibitol
Diethylene glycol monomethyl ether
Molecular
Formula: CSH,2O3
Structure: CH3 - O - CH2 ~ CH2.- O - CH2 - CH2 - OH
Chemical Properties
Molecular Weight: 120.15 Physical State: Liquid
Vapor Pressure: 0.2 ,mm at 20°C Vapor Density: 4.14
Boiling Point: 194.2°C Melting Point:
Density: 1.0354 at 20°C/4°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient: 1.14
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-98
-------
Diethylene glycol, monomethyl ether
PRODUCTION DATA
Annual U.S.
Production: 12.7 x 10* Ibs. Consumption: 12.7 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 1.0 duction Lost: 0.03
Release Rate (million Ibs/yr): 13.1
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 4160 mg/kg guinea pig oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-99
-------
Diethylene glycol, monomethyl ether acetate
CHEMICAL NAME
CAS Number: 629-38-9
Chemical Name: 2-(2-Methoxyethoxy)-ethanol, acetate
Synonyms: Methyl carbitol acetate
Molecular
Formula: C?H14O4
O
II
Structure: CH3 - C - O - CH2 - CH2 - O - CH2 - CH2 - O - CH3
Chemical Properties
Molecular Weight: 162.19 Physical State: Liquid
Vapor Pressure: 0.12 mm at 20°C Vapor Density:
Boiling Point: 209.1°C Melting Point:
Density: 1-0396 at 20°C/20°C Solubility: Infinite H2O
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-100
-------
Diethylene glycol, monomethyl ether acetate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of ' Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 3460 mg/kg guinea pig oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogeniclty: Not tested
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-101
-------
Diethylenetriamine
CHEMICAL NAME
CAS Number: 111-40-4
Chemical Name: 2,2'-Diethylenetriamine
Synonyms: 3-Azapentane-l,5-diamine
Bis [(3-aminoethyl] amine
DETA
Molecular
Formula: C4Hj-N,
H
I
Structure: NH2 - CH2 - CH2 - N - CH2 - CH2 - NH2
Chemical Properties
Molecular Weight: 103.17 Physical State: Liquid
Vapor Pressure: 0.22 mm at 20°C Vapor Density: 3.48
Boiling Point: 207°Cat760mm Melting Point: -39°C
Density: 0.9586 at 20°C/20°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD: 70% of theoretical after 20 days at 20°C
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
All-102
-------
Diethylenetriamine
PRODUCTION DATA
Annual U.S.
Production: 32.4 x 106 Ibs. Consumption: 32.4 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 0.50 duction Lost: 0.015
Release Rate (million Ibs/yr): 16:7
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 1080mg/kg rat oral
74 mg/kg rat intraperitoneal
71 mg/kg mouse intiaperitoneal
1090 mg/kg rabbit skin
1800 mg/kg guinea pig skin
Non-lethal Acute Effects:
Irritation of respiratory tract
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: TWA l ppm
Other Chronic Effects: Asthma and skin sensitization
AII-103
-------
Di(2-ethylhexyl) adipate
CHEMICAL NAME
CAS Number: 103-23-1
Chemical Name: Adipic acid, bis (2-ethylhexyl) ester
Synonyms: Bis-(2-ethyl hexyl) adipate Dioctyl adipate
Di-(2-ethylhexyl) adipate
DOA
Molecular
Formula: €22^04
O CH2 - CH3 "
II I
CH2 - C - O - CH2 - C - CH2 - CH2 - CH2 - CH3
I H
CH2
Structure: i
CH2
I H
CH2 - C - O - CH2 - C - CH2 - CH2 - CH2 - CH3
II ' I
O CH2 - CH3
Chemical Properties
Molecular Weight: 370.58 Physical State: Liquid
Vapor Pressure: <0.01 mm at 20°C Vapor Density: 12.8
Boiling Point: 214°Cat5mm Melting Point: -67.8°C
Density: 0.922 at 25°C/4°C Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Reacts with oxidizing materials
Unreactive towards RC>2 and Os
Activity toward OH: tw = 2.5 days
Safety Hazard: Fire-slight
AII-104
-------
Di(2-ethylhexyl) adipate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr): 39.4 (1972)
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD5o 900 mg/kg rat intravenous
540 mg/kg rabbit intravenous
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: Negative in rats given 6 gm/kg intraperitoneally in 2 months
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
All-105
-------
Di(2-ethylhexyl) phthalate
CHEMICAL NAME
CAS Number: 117-81-7
Chemical Name: Phthalic acid, bis (2-ethylhexyl) ester
Synonyms: Dioctylphthalate
Di-sec-octylphalate
OOP
Molecular , . ....
Formula: C24H38O4
Di(2-ethylhexyl) phthalate
Structure:
Chemical Properties
Molecular Weight: 390.6
Vapor Pressure: 1.3mmat200°C
Boiling Point: 230°C at 5 mm
Density: 0.9861 at 20°C/20°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Reacts with oxidizing materials
Unreactive towards ROj and 03
Activity towards OH: ti^ = 1 day
Safety Hazard:
Fire-slight
O/-1T¥
CH2
II I
C - O - CH2 - CH - CH2 - CH2 - CH2 - CH3
C - O - CH2 - CH - CH2 - CH2 - CH2 - CH3
II I •
O CH2
CH,
Physical State: Liquid
Vapor Density: 16.0
Melting Point: -46°C (pour point)
Solubility: Insoluble (H2O)
AII-106
-------
bi(2-ethylhexyl) phthalate
Annual U.S.
Production: 389.7(1974)
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost: 0.01S
Acute Toxicity
Non-lethal Acute Effects:
Gastrointestinal
TDLo
TOXICITY DATA
Dosage Animal
Route
143 mg/kg
oral
Conjunctivitis
Irritant to skin and bronchia
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 5 mg/m
Carcinogenicity: Neoplastic effects:
TDLo 43.2 gm/kg (96 weeks) rat
Mutagenicity:
TDLo
Teratogenicity:
15 gm/kg
30 gin/kg"
pregnant rat
TLV: 5 mg/m3
oral
intraperitoneal
intraperitoneal
rat(5-15 days
Other Chronic Effects: pregnant)
Embryotoxicity, reduced fetal size, growth retardation, metabolic disturbances, liver enlargement
and increased hexobental sleeping time
AII-107
-------
Diethylstilbestrol
CHEMICAL NAME
CAS Number: 56-53-1
Chemical Name: aX-DiethyM,4'-stilbenediol
Synonyms: Stilbesteiol
DES
4,4'-(l,2-Diethyl-l,2-ethenediyl)-bis-phenol
Molecular
Formula: Ci8H2oO2
Structure:
CH2CH3
Chemical Properties
Molecular Weight: 268.3
Vapor Pressure:
Boiling Point: 169 to 172°C
Density:
Octanol/Water Parti'
tion Coefficient: 5.07
Environmental Persistence
BOO:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point:
Solubility: Practically insoluble (H2O)
Safety Hazard:
Fire-slight
AII-108
-------
Diethylstilbestrol
Annual U.S.
Production: .004 x 106 Ibs.
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
LDLo
Non-lethal Acute Effects:
Glandular
TDLo
Dosage
34 mg/kg
67 mg/kg
2500 mg/kg
Animal
rat
mouse
mouse
60 /ig/kg (14 days) human
Route
intiapetitoneal
intraperitoneal
oral
skin
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
TDLo
102 gm/kg (2 years) rat
18 mg/kg (368 days) mouse
40 mg/kg (40 weeks) mouse
498 mg/kg (44 weeks) hamster
oral
oral
subcutaneous
implant
Cancerjn female offspring of women who took diethylstilbesterol during pregnancy
Mutagenicity: .
Tenitpgenicityj TLV:
Damage to reproductive tracts of male offspring of women who took diethylstilbesterol during pregnancy
Other Chronic Effects:
AII-109
-------
Diethyl suifate
CHEMICAL NAME
CAS Number: 64-67-5
Chemical Name: Sulfuric acid, diethyl ester
Synonyms: Ethyl
Diethyl suifate
Molecular
Formula: C4H10O4S
CT
i
Structure: H5C2O - S++ - OC2H5
I
o_
Chemical Properties
Molecular Weight: 154.18
Vapor Pressure: 1 mm at 47°C
Boiling Point: Decomposes to ethyl ether
Density: 1.1803 at 25°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 5.31
Melting Point: -24.4°C
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-moderate
All-110
-------
Diethyl sulfate
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
LDLo
TOXICITY DATA
Dosage Animal
350 mg/kg rat
340 mg/kg rat
647 mg/kg mouse
250 ppm (4 hours) rat
750 mg/kg rat
Route
subcutaneous
intravenous
oral
inhalation
oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
(neoplastic)
Mutagenicity:
1900 mg/kg (81 weeks) (intermittent) rat
800 mg/kg (49 weeks) (intermittent) rat
Teratogenicity:
TDLo
Other Chronic Effects:
6 mg/kg
85 mg/kg
mouse
TLV:
pregnant rat
oral
subcutaneous
intraperitoneal
intravenous
AII-111
-------
Difluroethane
CHEMICAL NAME
CAS Number: 75-37-6
Chemical Name: 1,1-Difluoroethane
Synonyms: Difluoroethane
Ethylene fluoride
Ethylidene fluoride
Molecular
Formula: CHF
H
I
Structure: F - C - CH,
Chemical Properties
Molecular Weight: 66.05 Physical State: Gas
Vapor Pressure: 76mmat21°C Vapor Density: 2.28
Boiling Point: -24.7 Melting Point: -117°C
Density: 0.95 at 20 (saturated pressure) Solubility: Insoluble (HjO)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
I'ire -dangerous
Disaster hazard-dangerous-fluorides
All-112
-------
Difluoroethane
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Non-lethal Acute Effects:
Irritant to lungs
Narcotic in high concentrations
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
All-113
-------
Difolatan
CHEMICAL NAME
CAS Number: 2425-06-1
Chemical Name: Difolatan
Synonyms: N-(l ,1,2,2-tetrachloioethylthio)-4-cyclohexone-l ,2-dicarboximide
Ortho 5865
Molecular
Formula: C10H9Cl4NO2S
Structure:
Chemical Properties
Molecular Weight: 349.06 Physical State: Solid
Vapor Pressure: Vapor Density:
Boiling Point: Melting Point: 160°C
Density: Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Disaster hazard-dangerous chlorides and SOX
AII-114'
-------
Difolatan
Annual U.S.
Production:
Fraction of
Dispersion:
2 x 106 Ibs.
PRODUCTION DATA
Consumption:
Estimated as 1.0
Release Rate (million Ibs/yr): 2.0
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD5o
Dosage
2500 mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
TDLo
Other Chronic Effects:
Reduced weight gain:
2500 ppm (9 weeks)
200 mg/kg
Animal
rat
Route
oral
TLV:
pregnant hamstei oral
tat
inhalation
AII-115
-------
Dihydrotrimethylquinoline
CHEMICAL NAME
CAS Number: 147-47-7
Chemical Name: l,2-Dihydro-2,2,4-trimethylquinoline
Synonyms: Acetone anil Acetonanil
Trimethyldihydroquinoline
2,2,4-TrimethyH,2,dihydroquinoline
Molecular
Formula: C^H^N
~CH3
Structure:
CH3
CH3
Chemical Properties
Molecular Weight: 173.3
Vapor Pressure: Negligible at 25°C
Boiling Point: Decomposes
Density: 1.03at25°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard: Fire-slight
Physical State: Solid
Vapor Density:
Melting Point: 120°C
Solubility: Insoluble (H2O)
AII-116
-------
Dihydrotrimethylquinoline
PRODUCTION DATA
Annual U.S.
Production: 30.0 x 106 Ibs.
Fraction of
Dispersion: 1.0
Release Rate (million Ibs/yr): 35.0
Consumption: 26.0 x 10 Ibs.
Fraction of Pro-
duction Lost: 0.30
TOXICITY DATA
Acute Toxicity
LDSO
Dosage
2000 mg/kg
1450 mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
Route
oral
oral
TLV:
AII-117
-------
Diisobutylene
CHEMICAL NAME
CAS Number: 12002-23-2
Chemical Name: Diisobutylene
Synonyms: 2,4,4-Trimethyl-l-pentene (a)
2,4,4-Trimethyl-2-pentene (b)
Molecular
Formula: C8H16
CH3
I
CH3
I
CH3
I
CHi
Structure: CH3 - C - CH2 - C = CH2
CH, - C -CH= C -
CH3
CH3
(a)
(b)
Chemical Properties
Molecular Weight: 112.22
Vapor Pressure:
Boiling Point: (a) 101.44"c
(b) 104,9rCat760rnm
6-
Density: (a) 0.7150 at 20 C/4 C
(b) 0.7218at20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid [(a) and (b)]
Vapor Density: (a) 3.97
Melting Point: (a) -93.48°C
(b) -106.33°C
Solubility: Insoluble [(a) and (b)] (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-dangerous
AII-118
-------
Diisobutylene
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXIC ITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity •'
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
Irritant and narcotic
Liver and kidney damage
AII-119
-------
Diisobutyl ketone
CHEMICAL NAME
CAS Number: 108-83-8
Chemical Name: 2,6-Dimethyl-4-heptanone
Synonyms: Isovalerone
Diisobutyl ketone
Molecular
Formula: C9HigO
CH3 O CH3
I II I
Structure: CH3 - CH - CH2 - C - CH2 - CH - CH3
Chemical Properties
Molecular Weight: 142.2 Physical State: Liquid
Vapor Pressure: Vapor Density: 4.9
Boiling Point: 168°C at 760mm Melting Point:
Density: 0.8053 at 20°C/4°C Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-120
-------
Diisobutyi ketone
PRODUCTION DATA
Annual U.S.
Production: • Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
1416 mg/kg mouse oral
2000 (ipm (4* hours) rat inhalation
Non-lethal Acute Effects:
Irritant
Narcotic in high concentrations
Chronic Toxicity
U.S. Occupational Standard: (air): TWA 25 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
All-121
-------
Diisodecyl phthalate
CHEMICAL NAME
CAS Number: 19-16-7
Chemical Name: 1,2-Benzenedicaiboxylic acid, bis(8-methylnonyl)ester
Synonyms: Diisodecyl phthalate
blDP"
Plasticizer DDP
Molecular
Formula: C28H88O4
Phthalic acid, bis(8-methylnonyl)ester
Structure:
O CR,
II I
C - (CH2)? CH - CH3
C - (CH2)? C - CH3
O CH,
Chemical Properties
Molecular Weight: 446.7
Vapor Pressure: <10 mm at 25°C
Boiling Point: 250 to 257°C
Density: 0.966 at 25°C/25°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 15.4
Melting Point: -50°C
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-slight
AII-122
-------
Diisodecyl phthalate
PRODUCTION DATA
Annual U.S.
Production: 153.3 x 106 Ibs. Consumption: 133.3 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 1.0 duction Lost: 0.015
Release Rate (million ibs/yr): 135.6
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-123
-------
Diisooctyl phthalate
CHEMICAL NAME
CAS Number: 27554-26-3
Chemical Name: 1,2-Benzenedicarboxylic acid, diisooctyl ester
Synonyms: DIOP
Diiso^ctylj>hthalate_ _
Phthalic acid, diisooctyl ester
Molecular
Formula: C24H38O4 .
6
C-O-C8H17
o it
Structure:
(CgH. 7 is predominantly isomeric dimethyl hexanols)
C-0-C8Hn
O
Chemical Properties
Molecular Weight: 390.5
Vapor Pressure: Negligible at 25°C
Boiling Point: 370°C
Density: 0.986 at 20°C/20°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 13.5
Melting Point: -50°C
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-slight
AII-124
-------
Diisooctyl phthalate
PRODUCTION DATA
Annual U.S. """ "
Production: 43.2 x 106 Ibs. (1973) Consumption: 43.2 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 1-0 duction Lost: 0.015
Release Rate (million Ibs/yr): Estimated at 43.2
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-125
-------
Diisopropylamine
CHEMICAL NAME
CAS Number: 108-18-9
Chemical Name: Diisopiopylamine
Synonyms:
Molecular
Formula: C6H1SN
Structure:
CH3
CH3
H ,
_
CH, - N - CH-,
CH3
CHi
Chemical Properties
Molecular Weight: 101.19
Vapor Pressure:
Boiling Point_ 84.1°C at 760 mm
Density: 0.7169 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 1.84
Physical State: Liquid
Vapor Density: 3.5
Melting Point: -61°C
Solubility: Slightly soluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-dangerous
AII-126
-------
Diisopropylamine
PRODUCTION DATA
Annual U.S.
Production: 2 x 106 Ibs. (1967) Consumption:
Fraction of Fraction of Pro-
Dispersion: 0.01 duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 700mg/kg rat oral
LCLo 1000 ppm (4 hours) rat inhalation
Non-lethal Acute Effects:
Pulmonary edema
Irritant to eyes and respiratory tract
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 5 ppm
Other Chronic Effects:
AII-127
-------
Diketene
CHEMICAL NAME
CAS Number: 674-82-8
Chemical Name: 4-Methylene-2-oxetanone
Synonyms: Acetyl ketene
3-Buteno-(3-lactone
Diketene
Molecular
Formula: C4H402
Structure: H2C — C - O
- i I
CH2 - C = O
Chemical Properties
Molecular Weight: 84.07
Vapor Pressure:
Boiling Point: 127.4°C
Density: 1.0897
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 2.9
Melting Point: -7.5°C
Solubility: Decomposes
Soluble (H2O)
Environmental Persistence
BOD;
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: File-moderate
AII-128
-------
Diketene
PRODUCTION DATA
Annual U.S.
Production: Dicketene-(none in 1975 in U.S.A.) Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD5o 560 mg/kg rat oral
800 mg/kg mouse oral
Non-lethal Acute Effects:
Irritant to skin and respiratory tract
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-129
-------
Dimethoate
CHEMICAL NAME
CAS Number: 60-51-5
Chemical Name: Phosphorodithioic acid, S-estei with 2-mercapto-N-methylacetamide O,O-dimethyl ester
Synonyms: O.O-dimethyl S-(N-methylcarbamoylmethyl)phosphorodithioate
Dimethoate
Molecular
Formula: C5H12NO3PS2
Structure:
CH
CHq
O
II
O
- S - CH2 - C - N - CH3
Chemical Properties
Molecular Weight: 229.3
Vapor Pressure: 0.025 mm at 25°C
Boiling Point: Decomposes
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Short-term air contaminant
Safety Hazard:
Physical State: Solid
Vapor Density:
Melting Point: 51to52°C
Solubility: Soluble (H2O) (1 to 2% at 27°C)
AII-130
-------
Dimethoate
Annual U.S.
Production:
Fraction of
Dispersion:
2.0 x 10° Ibs.
PRODUCTION DATA
Consumption:
Estimated as 1.0
Release Rate (million Ibs/yr): 2.0
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LDSO
LD
100
Dosage
30 mg/kg
147 mg/kg
353 mg/kg
250 mg/kg
350 mg/kg
37 mg/kg
7 mg/kg
250 mg/kg
300 mg/kg
150 mg/kg
Non-lethal Acute Effects:
Nausea
Lachrymation
Pulmonary edema
Convulsion
Anticholinesterase
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
human
rat
rat
rat
guinea pig
chicken
wild bird
7aT
cat
mouse
Route
oral
oral
skin
unknown
oral
oral
oral
oral
oral
oral
TLV:
AII-131
-------
Dimethoxybenzidine
CHEMICAL NAME
CAS Number: 119-9CM
Chemical Name: 3,3'-Dimethoxybenzidine
Synonyms: O-Dianisidine
Di-para-arninodi-meta-methoxydip'henyl
Molecular
Formula: C H NO
Chemical Properties
Molecular Weight: 244.29
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Physical State: Solid
Vapor Density: 8.5
Melting Point: 137tol38°C
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-slight
AII-132
-------
Dimethoxybenzidine
PRODUCTION DATA
Annual U.S.
Production: 0.367 x 10 Ibs. (1967) Consumption:
Fraction of Fraction of Pro-
Dispersion: <0.01 duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 1920mg/kg rat oral
3000 mg/kg dog oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Neoplasms:
TDLo 13gm/kg(52 weeks) rat oral
560 gm/kg (70 weeks) hamster oral
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AI1-133
-------
N, N-Dimethylacetamide
CHEMICAL NAME
CAS Number: 127-19-5
Chemical Name: N,N-dime thy lace tamide
Synonyms: DMAC
Molecular
Formula: c4H9NO
O
Structure: CH3 - C - N
CH,
CH,
Chemical Properties
Molecular Weight: 87.12
Vapor Pressure: 1.3 mm at 2S°C
Boiling Point: T65°c7f758 mm
Density: 0.9366 at 25°C/4°C
Octanol/Water Parti-
tion Coefficient: -0.77
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard: Fire-slight
Physical State: Liquid
Vapor Density: 3.01
Melting Point: -20°C
Solubility: Infinite (H2O)
AII-134
-------
N, N-Dimethylacetamide
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
LDSO
Non-lethal Acute Effects:
Systemic effects
TOXICITY DATA
2240 mg/kg
20ppm
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 10 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
TDLo
Other Chronic Effects:
60 mg/kg
Animal
rabbit
human
TLV:
pregnant rat
Route
skin
inhalation
intraperitoneal
AII-135
-------
Dimethylamine
CHEMICAL NAME
CAS Number: 124-40-3
Chemical Name: Dimethylamine
Synonyms: DMA
Molecular
Formula: C2H7N
Structure: H - N
CH,
CH-,
Chemical Properties
Molecular Weight: 45.08
Vapor Pressure: 1,290 mm at 25°C
Boiling Point: 7.4°C
Density: 0.6804 at 0°C/4°C
Octanol/Water Parti-
tion Coefficient: -0.38
Physical State: Gas
Vapor Density: 1.55
Melting Point: -93°C
Solubility: Very soluble
Environmental Persistence
BOD: Total theoretical oxygen demand 3.5 gm/gm
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-dangerous
Explosion-moderate
All-136
-------
Dimethylamine
PRODUCTION DATA
Annual U.S.
Production: 95.9 x 106 Ibs. Consumption: 95.9 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 0.20 duction Lost: 0.015
Release Rate (million Ibs/yr): 20.6
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 698 mg/kg rat oral
316 mg/kg mouse oral
240 mg/kg rabbit oral
240 mg/kg guinea pig oral
Chronic Toxicity
U.S. Occupational Standard: (air) 10 ppm
Carcinogenicity:
Mutagenicity: Increased incidence of ancuploid cells and structural chromosome changes in rats
Teratogenicity: TLV: lOppm
Other Chronic Effects:
Lung inflammation
Reduced growth rate
AII-137
-------
Dimethylaminoazobenzene
CHEMICAL NAME
CAS Number: 60-11-7
Chemical Name: C.I. Solvent yellow 2
Synonyms: N,N-Dimethyl-p-phenylazoaniline
p-Dimethylaminoazobenzene
.. . Benzeneazodimethylaniline
Molecular __.. _
Formula: cHN
Methyl yellow
Structure:
Chemical Properties
Molecular Weight:
Vapor Pressure:
Boiling Point: 116°C
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
CH
CH,
Physical State: Solid
Vapor Density:
Melting Point:
Solubility: Insoluble (H2O)
AII-138
-------
Dimethylaminoazobenzene
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
TOXICITY DATA
Dosage Animal
800 mg/kg "Tat
500 mg/kg rat
300 mg/kg mouse
230 mg/kg mouse
Route
oral
intraperitoneal
oral
intraperitoneal
Chronic Toxicity
U.S. Occupational Standard: (carcinogen)
Carcinogenicity:
Carcinogenic effects:
TD"
Lo
800 mg/kg (40 days)
155 mg/kg (4 weeks, intermittent)
Neoplastic effects:
TD, 11 gm/kg (12 weeks, continuous)
9600 mg/kg (42 weeks, intermittent)
Mutagemcity:
rat
rat
mouse
hamster
oral
skin
oral
oral
Teratogenicity:
Other Chronic Effects:
TLV:
AII-139
-------
Dimethylaniline
CHEMICAL NAME
CAS Number: 121-69-7
Chemical Name: N-N-Dimethylaniline
Synonyms: Dimethylaniline
Molecular
Formula: C8HUN
Structure:
Chemical Properties
Molecular Weight: 121.18 Physical State: Liquid
Vapor Pressure: 1 mm at 29.5°C Vapor Density: 4.17
Boiling Point: 193.1°C Melting Point: 2.5°C
Density: 0.9557 at 20°C/20°C Solubility: Slightly (H2O)
Octanol/Water Parti-
tion Coefficient: 2.62
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-moderate
Disaster hazard-dangerous-toxic fumes-aniline
AII-140
-------
Dimethylaniline
PRODUCTION DATA
Annual U.S.
Production: 15 x 106 Ibs. (1967) Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 1770mg/kg rabbit skin
LDko 50 mg/kg human oral
1410mg/kg rat oral
Non-lethal Acute Effects:
Depressant-CNS
Causes-weakness, tremours, tonic and colonic convulsions, slowness in respiration
Chronic Toxicity
U.S. Occupational Standard: (air) TWA skin 5 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-141
-------
Dimethylbutyl acetate
CHEMICAL NAME
CAS Number: Not listed in 9th Chemical Index
Chemical Name:
Synonyms: Acetic acid, 1,3-dimethylbutyl estei
Molecular
Formula: C8H16O2
/1TJ OO
Crlj 4 *""•$
i i
Structure: CH3 - C - O - CH - CH2 - CH - CH3
II
O
Chemical Properties
Molecular Weight: 144.24
Vapor Pressure:
Boiling Point: 130tol37°C
Density: 0.9
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fiie—moderate
Physical State:
Vapor Density: 5.0
Melting Point:
Solubility: Slightly soluble (H2O)
AII-142
-------
Dimethylbutyl acetate
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity Dosage
LCLo 4000 ppm
Non-lethal Acute Effects:
Eye irritation
TCLo 100 ppm
Animal
rat
human
Route
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard: TWA: SO ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AII-143
-------
Dimethyl ether
CHEMICAL NAME
CAS Number: 115-10-6
Chemical Name: Methyl ether
Synonyms: Methyl oxide
Methoxymethane
Dimethyl ether
Molecular
Formula: C2H6O
Structure: CH3 - O - CH3
Chemical Properties
Molecular Weight: 46.07
Vapor Pressure: 551.3 mm at 25°C
Boiling Point: -23.7°C at 760 mm
Density: 0^661
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-highly dangerous
Explosion-dangerous
Physical State: Gas
Vapor Density: 1.59
Melting Point: -138.5°C
Solubil ity: Sol7bTeT74~0~00 mg/1 H2O)~
All-144
-------
Dimethyl ether
PRODUCTION DATA
Annual U.S.
Production: , Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Central nervous system depressant
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-145
-------
N, N-Dimethylformamide
CHEMICAL NAME
CAS Number: 68-12-2
Chemical Name: N,N-Dimethylformamide
Synonyms: Formic acid, amide
Molecular
Formula: C3H7NO
O
Structure: CH, - N - C
3 i "H
CHi
Chemical Properties
Molecular Weight: 73.11
Vapor Pressure: 3.7 mm at 25°C
Boiling Point: 152.8°C at 760 mm
Density: 0.9445 at 25°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 2.51
Melting Point: -60.48°C
Solubility: Infinite (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-146
-------
N, N-Dimethylformamide
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 4200mg/kg rat oral
1260mg/kg rat intraperitoneal
3500 mg/kg rat subcutaneous
2350 mg/kg rat intravenous
3750 mg/kg mouse oral
650 mg/kg mouse intraperitoneal
470 mg/kg dog intravenous
400 mg/kg cat intiaperitoneal
1000 mg/kg rabbit intrapeiitoneal
1800 mg/kg rabbit intravenous
1030 mg/kg guinea pig intravenous
Non-lethal Acute Effects:
Central nervous system
irCf^,- 20ppm rat oral
Conjunctivitis
Nausea and vomiting
Anorexia
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 10 ppm (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 10 ppm
Other Chronic Effects: Liver damage
AII-147
-------
asym-Dimethylhydrazine
CHEMICAL NAME
CAS Number: 57-14-7
Chemical Name: 1,1-Dimethylhydrazine
Synonyms: Demazine
Asym-dimethylhydrazine
Molecular
Formula:
H CH3
\ /
Structure: N - N
/ \
H CK~
Chemical Properties
Molecular Weight: 60.10 Physical State: Liquid
Vapor Pressure: 157 mm at 25°C Vapor Density: 1.94
Boiling Point: 63.3°C at 752 mm Melting Point: -58°C
Density: 0.78 at 25°C/4°C Solubility: Very soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-dangerous
Disaster hazard-highly dangerous-toxic fumes
AII-148
-------
asym-Dimethylhydrazine
Annual U.S.
Production:
1.1 x 106 Ibs.
PRODUCTION DATA
Consumption:
Fraction of
Dispersion: 0.01
Release Rate (million Ibs/yr):
Fraction of Pro-
duction Lost: 0.0 IS
TOXICITY DATA
Acute Toxicity
LDSO
LC50
Dosage
122 mg/kg
102 mg/kg
265 mg/kg
125 mg/kg
60 mg/kg
1060 mg/kg
1329 mg/kg
252 ppm (4 hours)
172 ppm (4 hours)
3578 ppm (15 minutes)
392 ppm (4 hours)
Animal
rat
rat
rat
mouse
mouse
monkey
rabbit
guinea pig
rat
mouse
dog
Route
oral
intraperitoneal
oral
oral
intraperitoneal
intraperitoneal
intravenous
skin
inhalation
inhalation
inhalation
Non-lethal Acute Effects^
Irritant to eyes
Cardiovascular collapse
Chronic Toxicity
U.S. Occupational Standard: TWA: 1 mg/m3
Carcinogenicity:
TDLo
TDLo
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
7902 mg/kg (30 weeks)
140 mg/kg (8 weeks)
mouse
mouse
oral
intraperitoneal
TLV: 1 mg/m3
AI1-149
-------
sym-Dimethylhydrazine
CHEMICAL NAME
CAS Number: 57-14-7
Chemical Name: 1,2-Dimethylhydrazine
Synonyms: 1,2-Dimethylhydrazine
SDMH
Molecular
Formula: C2HgN2
CH,
CH-,
Structure: N - N
/ N
H H
Chemical Properties
Molecular Weight: 60.11
Vapor Pressure:
Boiling Point: 81°C at 753 mm
Density: 0.8274 at 20"C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State:
Vapor Density:
Melting Point:
Solubility: Infinitely soluble (H2O)
AII-150
-------
sym-Dimethylhydrazine
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
Dosage
100 mg/kg
220 mg/kg
95 mg/kg
280 ppm (4 hours)
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
TDLo
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
260 mg/kg (13 weeks)
146 mg/kg (31 weeks)
Animal
rat
rat
hamster
rat
Route
oral
subcutaneous
intramuscular
inhalation
hamster
hamster
TLV:
subcutaneous
intramuscular
AII-151
-------
l-(l, 4-Dimethylpentyl)-N-phenyl-p-phenylenediamine
CHEMICAL NAME
CAS Number: 3081-014
Chemical Name: N-(l ,4-dimethylpentyl)-N' phenyl-p-phenylenediamine
Synonyms:
Molecular
Formula:
CH3
I
CH3 H H
I I /=\ I /=\
Structure: CH3 - CH - CH2 - CH2 - CH - N -4 >- N -d *
Chemical Properties
Molecular Weight: 282.24
Vapor Pressure: Negligible at 25°C
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Activity toward RO^: t^ = 4 days
03: tvi= 1 day
OH: tvi = 1 day
Safety Hazard:
Physical State: Solid
Vapor Density:
Melting Point: 40 to 44°C
Solubility:
All-152
-------
, 4-Dimethylpentyl)-N-phenyl-p-phenylenediamine
PRODUCTION DATA
Annual U.S.
Production: 20 x 106 Ibs.
Fraction of
Dispersion: 0.90
Release Rate (million Ibs/yr): 16.8
Consumption: 18 x 10 Ibs.
Fraction of Pro-
duction Lost: 0.03
Acute Toxicity
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TOXICITY DATA
Animal
Route
TLV:
AII-153
-------
Dimethylphthalate
CHEMICAL NAME
CAS Number: 131-11-3
Chemical Name: Phthalic acid, dimethyl estei
Synonyms: o-Dimethyl phthalate
DMP
Molecular
Formula: C10H10O4
O
II
_ C - OCH3
I^V J
Structure: I |l
^^ C - OCH3
O
Chemical Properties
Molecular Weight: 194.18
Vapor Pressure: 0.01 mm at 20°C
Boiling Point: 283.7°C at 760 mm
Density: 1.1905 at 20.7°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density: 6.69
Melting Point: 0 to 2°C
Solubility: Very slightly (H2O)
All-154
-------
Dimethylphthaiate
PRODUCTION DATA
10.0xl06lbs. (1974)
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Consumption:
Fraction of Pro-
duction Lost:
0.015
TOXICITY DATA
Acute Toxicity
LCLo
1580 ihg/kg
4400 mg/kg
2400 mg/kg
8500 mg/kg
10,000 ppm
Animal
mouse
rabbit
guinea pig
chicken
cat
Route
intraperitoneal
oral
oral
oral
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air): TWA 5 mg/m3
Carcinogenicity:
Mutagenicity:
Teratogenicity:
TDLo 852 mg/kg
Other Chronic Effects:
TLV:
pregnant rat
intraperitoneal
All-155
-------
Dimethyl sulfate
CHEMICAL NAME
CAS Number: 77-78-1
Chemical Name: Sulfuric acid, dimethyl ester
Synonyms: Dimethyl sulfate
Methyl sulfate
Molecular
Formula: C2H6O4S
Structure: CH3 - O -
- O - CH
O(-)
Chemical Properties
Molecular Weight: 126.13
Vapor Pressure:
Boiling Point: 188°C (decomposes)
Density: 1.3322 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 4.35
Melting Point: -26.8°C
Solubility: Slight (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-moderate '
Disaster hazard-dangerous-SOx
All-156
-------
Dimethyl sulfate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-.
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 440mg/kg rat oral
100 mg/kg rat subcutaneous
100 mg/kg . rat intravenous
LDLo 32 ppm (4 hours) rat inhalation
75 ppm (17 minutes) mouse , inhalation
75 ppm (24 minutes) guinea pig inhalation
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: ,-—
TDLo: 17 mg/m (18 weeks, intermittent) rat inhalation
neoplastic effects
TDLo: 200 mg/kg Tat subcutaneous
. Mutagenicity:
Teratogenicity: . TLV: 1ppm
TDL0: 20 mg/kg pregnant rat intravenous
Other Chronic Effects:
AII-157
-------
Dimethyl sulfide
CHEMICAL NAME
CAS Number: 75-18-3
Chemical Name: Methyl sulfide
Synonyms: Dimethyl sulfide
Methanethiomethane
Molecular
Formula: C2H6S
Structure: CH3 - S - CH3
Chemical Properties
Molecular Weight: 62.08
Vapor Pressure: 530.8 mm at 25°C
Boiling Point: 37.3°C at 760 mm
Density: 0.8458 at 21°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 2.14
Melting Point: -98.27°C
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-dangerous
Explosion-moderate
Disaster hazard-dangerous—toxic fumes—SOX
AII-158
-------
Dimethyl sulfide
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ifas/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 535 mg/kg rat oral
3700 mg/kg mouse oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
All-159
-------
Dimethyl sulfoxide
CHEMICAL NAME
CAS Number: 67-68-5
Chemical Name: Methyl sulfoxide
Synonyms: Dimethyl sulfoxide
DMSO
Molecular
Formula: C2H6OS
O
II
Structure: CH3 - S - CH3
Chemical Properties
Molecular Weight: 78.14 Physical State: Liquid (hydroscopic)
Vapor Pressure: 0.37 mm at 20°C Vapor Density:
Boiling Point: 189°C at 760 mm Melting Point: 18.45°C
Density: 1.1014 at 20°C/4°C Solubility: Miscible (H2O)
Octanol/Water Parti-
tion Coefficient: -2.03
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-moderate
Disaster hazard-moderate-toxic fumes
All-160
-------
Dimethyl sulfoxide
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
Non-lethal Acute Effects:
Allergen
Irritant to skin
Corneal opacity
20 mg/kg
2500 mg/kg
Animal
rat
dog
Route
oral
intravenous
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
TDLo
Other Chronic Effects:
5gm/kg
8 gm/kg
5 gm/kg
50 mg/kg
TLV:
pregnant rat
pregnant rat
mouse
hamster
oral
intraperitoneal
intraperitoneal
intravenous
AII-161
-------
Dimethyl terephthalate
CHEMICAL NAME
CAS Number: 120-61-6
Chemical Name: Terephthalic acid, dimethyl ester
Synonyms: Dimethylterephthalate
DMT
Molecular
Formula: C10H10O4
1,4-Benzene dicarboxylic acid, dimethyl ester
Dimethyl 1,4-benzene carboxylate dimethyl ester
O
O
II
C - OCH3
Structure: CH3O - C
Chemical Properties
Molecular Weight: 194.19
Vapor Pressure: 1 mm at 100°C
Boiling Point: (sublimes)
Density: 1.194at20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Activity toward OH: reactive, estimated half life is 3 days
Safety Hazard:
Physical State: Solid
Vapor Density:
Melting Point: 141.0 to 141.8°C
Solubility: Slightly (hot H2O)
AII-162
-------
Dimethyl terephthalate
PRODUCTION DATA
Annual U.S. - -
Production: 2,714 x 106 Ibs. (1973) Consumption: 2,714 x 106lbs.
Fraction of Fraction of Pro-
Dispersion: 0 duction Lost: 0.015
Release Rate (million Ibs/yr): 32.5
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 4390mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: Negative in rat TLV:
Other Chronic Effects:
AII-163
-------
Dinitfobenzenes (m, o, and p)
CHEMICAL NAME
CAS Number: (m): 99-65-0 (o); 528-29-0
(p): 100-25-4 __ _
Chemical Name: (o): l,2-Dinitrobenzene~ (p): 1,4-Dinitrobenzene
(m): 1,3-Dinitrobenzene
Synonyms: Dinitrobenzol
Molecular
Formula: C6H4N2O4
Structure:
^ i>^
N02
(m)
Chemical Properties
Molecular Weight: 168.11
Vapor Pressure:
(o)
Physical State: Solid
Vapor Density: 5.79 (unspecified isomer)
Boiling Point: (m): 291°Cat 756rnnT
(p): 299°C at J77 mm
(o): 319°C atY73~mm
Density: (m): 1.575""at 18°C/4°C
(p): 1.625 at 18°C/4°C _
(o): 1.3 119atl20°C/40°C
Melting Point: (m):~ 90.02°C
(p): 174°C
(o): 118.5°C
Solubility: (m): Slightly (H26)
(p) and (o): Insoluble (H2O)
OctanolAVater Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: React with reducing materials
Safety Hazard:
Fire-slight
Explosion—severe
Disaster hazard-dangerous-toxic fumes-NOx
All-164
-------
Dinitrobenzenes (m, o, and p)
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
m-dinitrobenzene
LD50 42 mg/kg wild bird species oral
LDjo 27 mg/kg cat oral
p-dinitrobenzene
LDio 29 mg/kg cat. oral
Non-lethal Acute Effects: (unspecified isomer)
Anemia
Jaundice
Kidney damage
Injury to CNS
Chronic Toxicity
U.S. Occupational Standardj_(aii):
m-dinitrobenzene (air) 1 mg/m skin
p-dinitrobenzene (air) TWA 1 ppm skin
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 1 mg/m3
Other Chronic Effects:
AII-165
-------
Dinitrobenzoic acid
CHEMICAL NAME
CAS Number: 610-30-0
Chemical Name: 2,-4-Dinitrobenzoic add
Synonyms: Dinitrobenzoic acid
Molecular
Formula: C7H4N2O6
Structure:
NO2
Chemical Properties
Molecular Weight: 212.12
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Solid
Vapor Density:
Melting Point: 183°C
Solubility: Slightly (H2O)
AII-166
-------
Dinitrobenzoic acid
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal ' Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-167
-------
Dinitro-o-cresol
CHEMICAL NAME
CAS Number: 534-52-1
Chemical Name: 2-Methyl-4,6-dinitrophenol
Synonyms: 4,6-Dinitro-ortho-ciesol
DNOC
4,6-Dinitro-2-methyl phenol
Molecular
Formula: C7H6N2O5
Structure:
NO?
•\
NO>
CH,
OH
Chemical Properties
Molecular Weight: 198.14
Vapor Pressure: 1.05 x lO^mm at 25°C
Boiling Point: 312°C
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Solid
Vapor Density: 6.82
Melting Point: 85.8°C
Solubility: Slightly (H2O) (0.013% at 15°C)
AII-168
-------
Dinitro-o-cresol
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 25 mg/kg rat oral
200mg/kg rat skin
47 mg/kg mouse skin
19 mg/kg mouse intraperitoneal
LCLo 40mg/m3 cat inhalation
Non-lethal Acute Effects:
Central nervous system
TCLo 1 mg/m3 human inhalation
Irritant
Jaundice
Circulatory collapse
Mental disorder
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 200 jug/m3
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 200^g/m3
Other Chronic Effects:
AII-169
-------
2, 4-Dinitrophenol
CHEMICAL NAME
CAS Number: 25550-58-7
Chemical Name: Dinitrophenol
Synonyms: l-Hydroxy-2,4-dinitiobenzene
Molecular
Formula: C6H4N2O5
Structure:
NO2
Chemical Properties
Molecular Weight: 184.11
Vapor Pressure:
Boiling Point: Sublimes
Density: 1.683 at 24°C
Octanol/Water Parti-
tion Coefficient: 2.38
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Explosion-moderate
Physical State: Solid
Vapor Density: 6.35
Melting Point: H2°C
Solubility: 5600 mg/1 (H2O)
AII-170
-------
2, 4-Dinitrophenol
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
30 mg/kg
20 mg/kg
25 mg/kg
45 mg/kg
30 mg/kg
81 mg/kg
13 mg/kg
Non-lethal Acute Effects:
Liver damage and kidney damage
Metabolic stimulation
Dermatitis
Animal
rat
rat
rat
mouse
rabbit
guinea pig
wild bird
Route
oral
intraperitoneal
subcutaneous
subcutaneous
oral
oral
oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagen icily:
Teratogenicity:
Other Chronic Effects: Cataracts
TLV:
AII-171
-------
Dinitrotoluene
CHEMICAL NAME
CAS Number: 121-14-2
Chemical Name: 2,4-Dinitrotoluene
Synonyms: Dinitrotoluol
DNT
Molecular
Formula: C7H6N2O4
Structure:
Chemical Properties
Molecular Weight: 182.13 Physical State: Solid
Vapor Pressure: Vapor Density: 6.27
Boiling Point: 300°C (slight decomposition) Melting Point: 70.5°C
Density: 1.521 at 15°C/4°C Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-moderate
Explosion-moderate
AII-172
-------
Dinitrotoluene
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
Dosage
1625 mg/kg
268 mg/kg
50 mg/kg
Animal
mouse
rat
mammal
(species unspecified)
Route
oral
oral
subcutaneous
Non-lethal Acute Effects:
Anemia
Liver damage
CNS depression
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutageniciry:
Teratogenicity:
Other Chronic Effects:
TLV: 1.5 mg/kg
AII-173
-------
Dinoseb
CHEMICAL NAME
CAS Number: 88-85-7
Chemical Name: 2-(l-Methylpropyl)-4,6-dinitrophenol
Synonyms:
Molecular
Formula:
2,4-Dinitro-6-sec-butylphenol
DNBP
Butaphene
Structure:
N02
Chemical Properties
Molecular Weight: 240.2
Vapor Pressure: 1 mm at 151.1 C
Boiling Point: not determined
Density: 1.2647 at 45 C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density:
Melting Point: 32°C
Solubility: Slightly (H2O)
(0.0052 gm/gm at 25 C)
Safety Hazard:
Fire—possible risk
AII-174
-------
Dinoseb
Annual U.S.
Production:
3.0 x 106 Ibs.
PRODUCTION DATA
Consumption:
Fraction of
Dispersion: Estimated as 1.0
Release Rate (million Ibs/yr): 3.0
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LDSO
TOXICITY DATA
Dosage
25 mg/kg
80 mg/kg
20 mg/kg
8 mg/kg
20 mg/kg
40 mg/kg
60 mg/kg
7 mg/kg
Animal
rat
rat
mouse
mouse
guinea pig
chicken
mammal
wild bird
Route
oral
skin
oral
intiaperitoneal
oral
oral
unknown
oral
Non-lethal Acute^Effects:_
Irritant of eyes and lungs
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Metabolic stimulant
53 mg/kg
TLV:
pregnant rat
intraperitoneal
Growth depressant, 0.02% of diet (6 months) rats
AII-175
-------
Dioxane
CHEMICAL NAME
CAS Number: 123-91-1
Chemical Name: p-Dioxane
Synonyms: 1,4-Dioxane
Para-dioxane
Diethylene ether
Molecular
Formula: C4H8O3
Diethylene oxide
Dioxyethylene ether
1,4 Diethylene dioxide
Structure:
Chemical Properties
Molecular Weight: 88.1
Vapor Pressure: 39.7 mm at 25°C
Boiling Point: 101.3°C at 750mm
Density: 1.0337 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: -0.42
Environmental Persistence
BOD:
Atmospheric Reactivity:
Unreactive toward RC>2 and 63
Activity toward OH: Very reactive
Physical State: Liquid
Vapor Density: 3.03
Melting Point: H.8°C
Solubility: Infinite (H2O)
= 9.6 hours
Safety Hazard:
Fire-dangerous
Explosion-moderate
AII-176
-------
Dioxane
PRODUCTION DATA
Annual U.S.
Production: 13.8 x 106 Ibs.
Fraction of
Dispersion: 1.0
Release Rate (million Ibs/yr): 14.0
Consumption: 13.8 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LDSO
LCLo
TOXICITY DATA
Dosage
790 mg/kg
2000 mg/kg
2000 mg/kg
3150 mg/kg
470 ppm
Animal
mouse
cat
rabbit
guinea pig
human
Route
intiaperitoneal
oral
oral
oral
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air): TWA 100 ppm skin
Carcinogenicity: TDj,,,: 416 gm/kg/57 weeks continuous hepatocarcinomas,
kidney carcinomas, carcinomas
Mutagenicity:
Teratogenicity:
TLV: 100 ppm
Other Chronic Effects:
Inhalation causes irritability followed by narcosis, edema and death
Liver and kidney damage
Edema of the brain and lungs
AII-177
-------
Dioxolane
CHEMICAL NAME
CAS Number: 646-06-0
Chemical Name: 1,3-Dioxolane
Synonyms: Dioxolane
Glycol methylene ether
Molecular
Formula: C3H6O2
-O
Structure: 6
Chemical Properties
Molecular Weight: 74.08 Physical State: Liquid
Vapor Pressure: 70 mm at 20°C Vapor Density: 2.6
Boiling Point: 75°C at 765 mm Melting Point: -95°C
Density: 1.0600 at 20°C/4°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-dangerous
AII-178
-------
Dioxolane
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 3000mg/kg rat oral
729 mg/kg mouse intraperitoneal
Non-lethal Acute Effects:
TDL0 7 mg/kg human oral
Psychotropic effect
Inhalation and ingestion can have moderate effects
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-179
-------
Diphenamid
CHEMICAL NAME
CAS Number: 957-51-7
Chemical Name: N,N-Dimethyl-a-phenylbenzeneacetamide
Synonyms: N,N-Dimethyl-2,2-diphenylacetainide
Molecular
Formula: C16H17NO
Structure:
H O
I H >
C - C - N
x
CH,
Chemical Properties
Molecular Weight: 239.32
Vapor Pressure:
Boiling Point: decomposes at 210°C
Density: 1.17at23.3°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 134.5 to 135.5°C
Solubility: Slightly soluble (H2O)
(0.026 gm/100 ml at 27 C)
Relatively resistant to decomposition by ultraviolet irradiation
Safety Hazard:
AII-180
-------
Diphenamid
Annual U.S.
Production: 3.0xl06lbs.
Fraction of
Dispersion: Estimated as 1.0
Release Rate (million Ibs/yr): 3-°
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
0.015
TOXICITY DATA
Acute Toxicity
293 mg/kg
600 mg/kg
500 mg/kg
800 mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Emetic
May produce convulsions
Animal
rat
mouse
mouse
mouse
Route
oral
oral
intrapeiitoneal
subcutaneous
TLV:
AII-181
-------
Diphenyl
CAS Number: 92-52-4
Chemical Name: Biphenyl
Synonyms: Diphenyl
Molecular
Formula: C12H10
CHEMICAL NAME
Structure:
Chemical Properties
Molecular Weight: 154.22
Vapor Pressure: 0.017 psiat71.1°C
Boiling Point: 255.9°C at 760 mm
Density: 0.8660 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
4.09
Physical State: Solid
Vapor Density: 5.31
Melting Point: 71°C
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-slight
AII-182
-------
Diphenyl
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
LDSO
Non-lethal Acute Effects:
Irritant effects
TDLo
TOXICITY DATA
3280 mg/kg
2400 mg/kg
2500 mg/kg
4400 /ug/m3
Paralysis and convulsions
Animal
rat
rabbit
rabbit
human
Route
oral
oral
skin
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air): TWA 0.2 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 0.2 ppm
AII-183
-------
Diphenylamine
CHEMICAL NAME
CAS Number: 122-39-4
Chemical Name: Diphenylamine
Synonyms: Phenylaniline
Anilinobenzene
DPA
Molecular
Formula: C^HuN
Structure: / VN-<( }>
\: ff H v y
Chemical Properties
Molecular Weight: 169.24
Vapor Pressure: 1 mm at 108.3°C
Boiling Point: 302°C
Density: 1.160 at 22 C/20 C
Octanol/Water Parti-
tion Coefficient: 3.50
Physical State: Solid
Vapor Density: 5.82
Melting Point: 52.85°C
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-slight
Disaster hazard-dangerous-toxic fumes
AII-184
-------
Diphenylamine
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDLo 3000mg/kg rat oral
250 mg/kg mouse intraperitoneal
Non-lethal Acute Effects:
CNS depression
Cardiac arrhythmia
Liver and kidney damage
Hypertension
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: Recognized carcinogen
Mutagenicity:
Teratogenicity: TLV: 1 mg/m3
TDi_,0: 7500 mg/kg pregnant rat oral
Other Chronic Effects:
AII-185
-------
Diphenyl oxide
CHEMICAL NAME
CAS Number: 101-84-8
Chemical Name: Phenyl ether
Synonyms: Diphenyl oxide
Diphenyl ether
Molecular
Formula:
Structure:
Chemical Properties
Molecular Weight: 170.20
Vapor Pressure: l mm at 66°C
Boiling Point: 258°C at 760 mm
Density: 1.0728 at 20°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density: 5.86
Melting Point: 27°C
Solubility: Insoluble (H2O)
Reacts with oxidizing materials
Safety Hazard:
Fire-moderate
All-186
-------
Diphenyl oxide
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
LDso
Non-lethal Acute Effects:
Slight irritant
TOXICITY DATA
3370 mg/kg
Animal
rat
Chronic Toxicity
U.S. Occupational Standard: (air): TWA 1 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
TLV:
Other Chronic Effects:
Liver, spleen, kidney, thyroid and gastrointestinal system
Route
oral
AII-187
-------
Diphenylthiourea
CHEMICAL NAME
CAS Number: 102-08-9
Chemical Name: Thiocarbanilide
Synonyms:
Molecular
Formula:
Diphenylthiourea
N ,N-Dipheny Ithiourea
l,3-Diphenyl-2-thiourea
Ci3HI2N2S
Structure:
N - C - N
H H
Chemical Properties
Molecular Weight: 228.33
Vapor Pressure:
Boiling Point: Decomposes
Density: 1.32at25°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 148°C
Solubility: Insoluble (H2O)
Safety Hazard:
Disaster hazard-dangerous-toxic fumes—SOX
AII-188
-------
Diphenylthiourea
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD5o 500 mg/kg mouse intraperitoneal
LDLo 720 mg/kg cat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-189
-------
Dipropylene glycol
CHEMICAL NAME
CAS Number: 106-62-7
Chemical Name: Dipropylene glycol
Synonyms: 2,2'-Dihydroxy dipropyl ether
Molecular
Formula:
OH OH
I I
Structure: CH3 - C - CH2 - O - CH2 - C - CH3
I I
Chemical Properties
Molecular Weight: 134.17 Physical State: Liquid
Vapor Pressure: 0.01 mm at 20°C Vapor Density: 4.63
Boiling Point: 231.8°C Melting Point:
Density: 1.0252 at 20°C/20°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient: -1.23
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-slight
All-190
-------
Dipropylene glycol
PRODUCTION DATA
Annual U.S.
Production: 67 x 106 Ibs. Consumption:
(1976 capacity)
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.01S
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
None listed
(Moderate)
Non-lethal Acute Effects:
Moderate effects
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-191
-------
Dipropylene glycol, monomethyl ether
CHEMICAL NAME
CAS Number: 20324-32-7
Chemical Name: Dipropylene glycol monomethyl ether
Synonyms: Dowanol SOB
Molecular
Formula: C7Hi6O3
OCH3 OH
I I
Structure: CH3 - C - CH2 - O - CH2 - C - CH3
H H
Chemical Properties
Molecular Weight: 148.20
Vapor Pressure: Negligible
Boiling Point: 189°C
Density: 0.950 at 25°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 5.11
Melting Point^-80°C
Solubility: Infinite (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
All-192
-------
Dipropylene glycol, monomethyl ether
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 7500mg/kg dog oral
LDLo 4900 rag/kg rat oral
Chronic Toxicity
U.S. Occupational Standard: (aii): TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
All-193
-------
Disodium methanearsonate
CHEMICAL NAME
CAS Number: 144-21-8
Chemical Name: Methaneaisonic acid, disodium salt
Synonyms: DMA
Disodium methanearsonate
Crab-e-iad
Molecular
Formula: CH3As63'2Na"
O ONa
II /
Structure: CHo - As
ONa
Chemical Properties
Molecular Weight: 183.94
Vapor Pressure: Very low
Boiling Point:
Density: ca. 1.0
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Arsinyl
DSMA
Physical State: Solid
Vapor Density:
Melting Point: 132 to 139°C
Solubility: Very soluble (H2O)
AII-194
-------
Disodium methanearsonate
Annual U.S.
Production: 35.0 x 106 Ibs.
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost: 0-015
TOXICITY DATA
Acute Toxicity
LDSO
Dosage
1800mg/kg
600mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
Route
oral
oral
TLV:
AII-195
-------
Disulfoton
CHEMICAL NAME
CAS Number: 298-044
Chemical Name: Phosphorodithioic O,O-diethyl S-[2-(ethylthio)ethyl] ester
Synonyms: Di-Syston
Molecular
Formula: CgHi9O2PS3
CH3 - CH2 - O S
Structure:
P - S - CH2CH2 - S - CH2CH3
CH, - CH, - O
Chemical Properties
Molecular Weight: 274
Vapor Pressure:
Boiling Point: 62°C at 0.001 mm
Density: 1.144 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility: Very slightly (H2O) (1:40,000)
Safety Hazard:
AII-196
-------
Disulfoton
Annual U.S.
Production:
Fraction of
Dispersion:
PRODUCTION DATA
8.0xl06lbs. Consumption:
Fraction of Pro-
1.0 duction Lost:
0.015
Release Rate (million Ibs/yr): 8.0
TOXICITY DATA
Acute Toxicity
LD50
Dosage
6 mg/kg
5400 /jg/kg
2500 Mg/kg
7 mg/kg
3.2 mg/kg
12.5 mg/kg
2.6 mg/kg
20. mg/kg
Animal
rat
rat
rat
mouse
wild bird
male~raT
female rat
male rat
Route
skin
intiaperitoneal
unknown
intraperitoneal
oral
oral" " ~~
oral
dermal
Chronic Toxicity
U.S. Occupational Standard: (air) TWA Mg/m3
Carcinogenicity:
Mutagenicity:
Teratogenicity:
TLV:
Other Chronic Effects:
Chronic oral: 10 ppm (16 weeks) reduced cholinesterase in rat
All-197
-------
Ditridecylphthalate
CHEMICAL NAME
CAS Number: 119-06-2
Chemical Name: Phthalic acid, ditridecyl ester
Synonyms: Ditiidecylphthalate
DTDP
Molecular
Formula: C34Hs8O4
Structure:
O
C - O - (CH2)12CH3
C - O - (CH2)12CH3
II
O
Chemical Properties
Molecular Weight: 538
Vapor Pressure:
Boiling Point: >285°C at 5 mm
Density: 0.951 at 20°C/20°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density:
Melting Point: -37° C (pour point)
Solubility:
Safety Hazard:
Fire-slight
All-198
-------
Ditridecylphthalate
PRODUCTION DATA
Annual U.S. _ _
Production: 27.2 x 106 Ibs. (1974) Consumption: 27.2 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 1-0 duction Lost: 0.015
Release Rate (million Ibs/yr): 24.3 (1972)
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-199
-------
Diuroii
CHEMICAL NAME
CAS Number: 330-54-1
Chemical Name: 3-(3,4-Dichlorophenyl)-l,l-dimethylurea
Synonyms:
Molecular
Formula: C9Hi0Cl2N2O
Cl
Structure: Cl
0 CH3
H II /
N - C - N
CH,
Chemical Properties
Molecular Weight: 233.11
Vapor Pressure: 2 x 10~7 mm at 30°C
Boiling Point: 180°C (decomposes)
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Photodecomposition insignificant
Physical State: Solid
Vapor Density:
Melting Point: 153 to 155°C
Solubility: 42 ppm at 25°C in distilled water
Safety Hazard:
Disaster hazard-dangerous-toxic fumes
AII-200
-------
Diuron
PRODUCTION DATA
Annual U.S.
Production: 6.0 x 10 Ibs. Consumption:
Fraction of Fraction of Pro-
Dispersion: Estimated as 1.0 duction Lost: 0.015
Release Rate (million Ibs/yr): 6-°
TOXICITY DATA
Acute Toxicity Dosage Animal Route
437 mg/kg rat oral
3400 mg/kg rat oral
500 mg/kg mouse intraperitoneal
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
Irritant to eyes, nose, throat, and skin
AII-201
-------
Dodecane
CHEMICAL NAME
CAS Number: 112-40-3
Chemical Name: Dodecane
Synonyms: Bihexyl
Dihexyl
Molecular
Formula: Ci2H26
Structure:
Chemical Properties
Molecular Weight: 170.3
Vapor Pressure: 1 mm at 478°C
Boiling Point: 213°Cat760mm
Density: 0.749 at 20°C/4°C
Octanol/Watef Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fiie-moderate
Physical State: Liquid
Vapor Density: 5.96
Melting Point: -10°C
Solubility: Insoluble (H2O)
All-202
-------
Dodecane
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: - TLV:
Other Chronic Effects:
AII-203
-------
Dodecy I benzene
CHEMICAL NAME
CAS Number: 25265-78-5
Chemical Name: Dodecyl benzene
Synonyms: Alkane
Detergent alkylate
Molecular
Formula: C18H30
Structure: - c12H25
Chemical Properties
Molecular Weight: 246.48 Physical State: Liquid
Vapor Pressure: <10 mm at 75°C Vapor Density: 8.47
Boiling Point: 290°C Melting Point:
Density: 0.9 Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-slight
AII-204
-------
Dodecylbenzene
PRODUCTION DATA
Annual U.S.
Production: 523.3 x 106lbs. (1975) Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-205
-------
Dodecylbenzenesulfonic acid, sodium salt
CHEMICAL NAME
CAS Number: 12068-21-2
Chemical Name: Dodecylbenzenesulfonic acid, sodium salt
Synonyms: Sodium linear alkylatesulfonate (C12)
Sodium laurylbenzenesulfonic acid
Molecular
Formula: C18H30O3S
CH
Structure:
(CH2)y
CH3(CH2)X - C
H
O
S - 0<->Na+
n
Chemical Properties
Molecular Weight: 349.54
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Unreactive toward RO2
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility: Soluble (400 gm/1 H2O)
Safety Hazard:
AII-206
-------
Dodecylbenzenesulfonic acid, sodium salt
Annual U.S.
Production: 364.1 x 106 Ibs.
Fraction of
Dispersion: 1-0
Release Rate (million Ibs/yr): 369.5
PRODUCTION DATA
Consumption:
364.1 x 10" Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LDSO
Dosage
1260mg/kg
2000 mg/kg
105 mg/kg
Animal
rat
mouse
mouse
Non-lethal Acute Effects:
Skin and mucous membrane irritation
Increased sensitivity to glucose loads
Increased liver weight and fasting sugar level
Decreased growth rate and food consumption
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: Negative in rat & mouse
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
Route
oral
oral
intravenous
All-207
-------
Dodecyl mercaptan
CHEMICAL NAME
CAS Number: 112-55-6"
Chemical Name: 1-Dodecanethiol
Synonyms: DDM
Lauryl meicaptan.
Lauiyl mercaptide
N-Dodecyl mercaptan
N-dodecyl mercaptan
Molecular
Formula: C12H26S
Structure: CH3(CH2)10CH2SH
Chemical Properties
Molecular Weight: 202.4
Vapor Pressure: Negligible
Boiling Point: 142 to 145°C at 15 mm
Density: 0.845 at 20°C/20°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 6.98
Melting Point: -7.5°C
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-moderate
Disaster hazard-dangerous-sulfates
AII-208
-------
Dodecyl mercaptan
PRODUCTION DATA
Annual U.S.
Production: 15 x 106 Ibs. Consumption: 15.2 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 0.98 duction Lost:. °-02
Release Rate (million Ibs/yr): 15.2
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD5Q 309 mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-209
-------
Dodecylphenol
CHEMICAL NAME
CAS Number: 1331-57-3
Chemical Name: Dodecylphenol
Synonyms: Mixture of dodecylphenol isomers
Molecular
Formula: C18H30O
Structure: HO
- (CH2)10 - CH3
Chemical Properties
Molecular Weight: 262.4
Vapor Pressure: <10mmat25°C
Boiling Point: 154 to 168°C
Density: 0.94 at 20°C/20°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 9.04
Melting Point:
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Disaster hazaid-moderate-toxic fumes
All-210
-------
Dodecylphenol
PRODUCTION DATA
Annual U.S.
Production: 17.4 x 106 Ibs.
Fraction of
Dispersion: 1-0
Release Rate (million Ibs/yr): 17.9
Consumption: 17.4 x 10 Ibs.
Fraction of Pro-
duction Lost: 0.03
TOXICITY DATA
Acute Toxicity
LDso
Non-lethal Acute Effects:
Strong irritant
Dosage
2140 mg/kg
5000 mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
rabbit
Route
oral
skin
TLV:
All-211
-------
Dodecyl sulfate, sodium salt
CHEMICAL NAME
CAS Number: 151-21-3
Chemical Name: Sulfuric acid monododecyl ester sodium salt
Synonyms: Dodecyl sulfate, sodium salt
Lauryl sodium sulfate
SDS
Molecular
Formula: C12H2sO4S'Na
Structure: CH3(CH2)ioCH2 - OSO3-Na
Chemical Properties
Molecular Weight: 289.44
Vapor Pressure: Negligible
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient: 1.60
Environmental Persistence
BOO:
Atmospheric Reactivity:
Sodium dodecyl sulfate
Sodium lauryl sulfate
Safety Hazard:
Physical State: Solid
Vapor Density:
Melting Point:
Solubility: Soluble (H2O)
All-212
-------
Dodecyl sulfate, sodium salt
PRODUCTION DATA
Annual U.S.
Production: 26.8 x 106 Ibs. Consumption: 26.8 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 1-0 duction Lost: 0.03
Release Rate (million Ibs/yr): 27.6
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 1300mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-213
-------
Dodecyl sulfate, triethanolamine salt
CHEMICAL NAME
CAS Number: 139-96-8
Chemical Name: Sulfuricacid, monododecyl ester, compd. with 2,2',2"-nitrilotris[ethanol] (1:1)
Synonyms: Triethanolamine lauryl sulfate
Molecular
Formula: C18H4iNO7S
Structure: CH3(CH2)10CH2 - O -
Chemical Properties
Molecular Weight: 415.59
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
N - (CH2CH2OH)3
H
Safety Hazard:
Physical State:
Vapor Density:
Melting Point:
Solubility:
Liquid or paste
AII-214
-------
Dodecyl sulfate, triethanolamine salt
PRODUCTION DATA
Annual U.S.
Production: 16.1 x 106 Ibs. Consumption: 16.1 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: Estimated as 1.0 duction Lost: 0.03
Release Rate (million Ibs/yr): 16.5
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
All-215
-------
Dursban
CHEMICAL NAME
CAS Number: 2921-88-2
Chemical Name: Phosphoiodithioic acid, O,O-diethyl-O-(3,5,6-trichloro-2-pyridinyl)ester
Synonyms: O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)phosphorothioate
Molecular
Formula:
Structure:
Cl
Cl
Cl OC2H5
x
O - P
S ^ OC2H5
Chemical Properties
Molecular Weight: 349.5
Vapor Pressure: 1.87 x 10"5 mm
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 41 to 43°C
Solubility: "VeFy~sl!ghtly~(H2~6) (OXHJ02 gm/100 ml)
Safety Hazard:
Disaster hazard-dangerous-chlorides, parathion
AII-216
-------
Dursban
Annual U.S.
Production:
5.Ox ICTlbs.
PRODUCTION DATA
Consumption:
Fraction of
Dispersion: Estimated as 1.0
Release Rate (million Ibs/yr): 5.0
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LDSO
TOXICITY DATA
Dosage
145 mg/kg
202 mg/kg
150 mg/kg
2000 mg/kg
500 mg/kg
27 mg/kg
24 mg/kg
16 mg/kg
76 mg/kg
8 mg/kg
Animal
rat
rat
rat
rabbit
guinea pig
pigeon
chicken
quail
duck
wild bird
Route
oral
skin
unreported
skin
unreported
oral
oral
oral
oral
oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AII-217
-------
Dyfonate
CHEMICAL NAME
CAS Number: 944-22-9
Chemical Name: Ethylphosphonodithioic acid, O-ethyl,S-phenyl ester
Synonyms: O-Ethyl-S-phenylethylphosphodithioate
Molecular
Formula: C10H,5OPS2
C2H5 - O
Structure:
Chemical Properties
Molecular Weight: 246.34
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density:
Melting Point: 100°C at 0.3 mm Hg.
Solubility:
Safety Hazard:
Disaster hazard—dangerous-phosphates
AII-218
-------
Dyfonate
PRODUCTION DATA
Annual U.S.
Production: 2.0 x 106 Ibs. Consumption:
Fraction of Fraction of Pro-
Dispersion: Estimated as 1.0 duction Lost: 0.015
Release Rate (million Ibs/yr): 2.0
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 3mg/kg rat oral
147 mg/kg rat skin
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-219
-------
Endosulfan
CHEMICAL NAME
CAS Number: 115-29-7
Chemical Name: l)4,5,6)7,7-Hexachloro-5-norbornene-2,3-dimethanol,cyclic sulfite
Synonyms: Thiodan
6,7,8,9,10,10-Hexachloro-l,5,5a,6,9,9a-hexahydro-6,9-methano-2,
3,4-benzo (e)-dioxathiepin-3-oxide
Molecular C9H6C16O3S
Formula:
Structure:
CKU-O
S = 0
CH,-O
Chemical Properties
Molecular Weight: 406.91
Physical State: solid
Vapor Pressure: (no measurable pressure at 75°C) Vapor Density:
Boiling Point: Melting Point: 106°C
Density: 1.745 at 20°C/20°C Solubility: Nearly insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AII-220
-------
Endosulfan
PRODUCTION DATA
Annual U.S.
Production: 2.0 x 106 Ibs. Consumption:
Fraction of Fraction of Pro-
Dispersion: 1.0 duction Lost: 0.015
Release Rate (million Ibs/yr): 2.0
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 18 mg/kg rat oral
74 mg/kg rat , skin
40 mg/kg rat unreported
359 mg/kg rabbit skin
34 mg/kg duck oral
35 mg/kg wild bird oral
affects central nervous system
Chronic Toxicity
U.S. Occupational Standard: (air) TWA: 100 jjg/m3 (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity: • TLV:
Other Chronic Effects:
AII-221
-------
Endothal
CHEMICAL NAME
CAS Number: 145-73-3
Chemical Name: 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic acid
Synonyms: 3,6-Endohexanhydiophthalic acid
Molecular
Formula:
O
/r^_
Structure:
O
Chemical Properties
Molecular Weight: 232.16 Physical State: Solid
Vapor Pressure: Vapor Density:
Boiling Point: Slowly decomposes above 90°C Melting Point: ca. 144°C when heated rapidly
(decomposes) _
Density: 1.431 Solubility: Soluble (10 gm/100gmH2O at 20°C)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AII-222
-------
Endotha!
Annual U.S.
Production:
Fraction of
Dispersion:
2.0 x 106 Ibs.
1.0
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lest: 0.015
Release Rate (million Ibs/yr): 2.0
TOXICITY DATA
Acute Toxicity
Dosage
38 to 51 mg/kg
5T mg/kg
750 mg/kg
100 mg/kg
50 mg/kg
5 mg/kg
200 mg/kg
5 mg/kg
250 mg/kg
Animal
rat
rat
rat
rabbit
mouse
dog
rabbit
rabbit
guinea pig
Route
oral
oral
skin
skin
oral
intravenous
oral
intravenous
oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Irritant to skin, nose, eyes, and throat
Greatest occupational hazard-eye irritation
by burning of exposed tissues
TLV:
AII-223
-------
Epichlorohydrin
CHEMICAL NAME
CAS Number: 106-89-8
Chemical Name: l-Chloro-2,3-epoxypropane
Synonyms: a: 3-Chloro-l,2-propylene (3 : 3-Chloro-l-oxacyclobutane
3-Chlorooxetane
Molecular
Formula: C3HSC1O
O CH2-O
/ I II,
Structure: CH2CHCH2C1 Cl - CH - CH2
Chemical Properties (a)
Molecular Weight: 92.53 Physical State: Liquid
Vapor Pressure: 16.8 mm at 25°C Vapor Density: 3.29
Boiling Point: 117.9°C Melting Point: -48°C
Density: 1.1801 at 20°C/4°C Solubility: Slightly soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
Disaster hazard-dangerous, toxic fumes-phosgene
AII-224
-------
Epichlorohydrin
PRODUCTION DATA
Annual U.S. __
Production: 495 x 106 Ibs. (1974)
Fraction of
Dispersion: 0.01
Release Rate (million Ibs/yr):
Consumption: ca. 396 x 10 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LC
50
Non-lethal Acute Effects:
Eye effects:
TD,
Lo
Dosage
90 mg/kg
238 mg/kg
155 mg/kg
100 mg/kg
250 ppm (4 hours)
20ppm
Chronic Toxicity
U.S. Occupational Standard:
TWA : 5 ppm
Carcinogenicity:
Neoplastic effects:"
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
19 mg/kg
720 mg/kg
Animal
rat
mouse
mouse
rabbit
rat
human
mouse
mouse
TLV:
Route
oral
oral
intraperitoneal
skin
inhalation
inhalation
inhalation
subcutaneous
AII-225
-------
Eptam
CHEMICAL NAME
CAS Number: 759-94-4
Chemical Name: S-Ethyldipiopylthiocaibamate
Synonyms: Dipropylthiocarbamic acid, S-ethyl ester
S-Ethyl-N,N-propylthiocarbamate
Molecular
Formula:
C9H19NOS
Structure: CH3 - CH2 - S - C - N
CH2 - CH2 - CH3
CH2 - CH2 - CH3
Chemical Properties
Molecular Weight: 189.35
Vapor Pressure:
Boiling Point: 232°C at 760 mm
Density: 0.9546 at 30°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility: Very slightly "soluble (H2O)
Safety Hazard:
AII-226
-------
Eptam
PRODUCTION DATA
Annual U.S.
Production: 5 x 106 Ibs. Consumption:
Fraction of Fraction of Pro-
Dispersion: 1.0 duction Lost: 0.015
Release Rate (million Ibs/yr): 5.0
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 1630 rag/kg rat oral
750 mg/kg mouse oral
112mg/kg cat oral
146 mg/kg rabbit . skin
100 mg/kg wild bird oral
200 mg/m3/(3 hours) rat inhalation
400 mg/m /(3 hours) cat inhalation
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: Neoplastic
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-227
-------
Ethane
CHEMICAL NAME
CAS Number: 74-84-0
Chemical Name: Ethane
Synonyms: Bimethyl
Dimethyl
Ethyl hydride
Molecular
Formula: C2Hft
Me Me
Methylmethane
Structure: CH3 - CH3
Chemical Properties
Molecular Weight: 30.07
Vapor Pressure: 255 mm at 21 C
Boiling Point: -88.63°C
Density: 0.446 at 0°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Physical State: Gas
Vapor Density: 1.04
Melting Point: -183.3°C
Solubility: Insoluble (H2O)
Safety Hazard: Fiie-dangerous
Explosion-moderate
AII-228
-------
Ethane
PRODUCTION DATA
Annual U.S. - -
Production: 5,485 x 106lbs. (1973) Consumption: 5,485 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 0 duction Lost: 0.01
Release Rate (million Ibs/yr): 54.9~
TOXIC ITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-229
-------
Ethanoiamine
CHEMICAL NAME
CAS Number: 141-43-5
Chemical Name: 2-Aminoethanol
Synonyms: 2-Aminoethanol
Monoethanolamine
(3-Ethanolamine
Molecular
Formula: C2H7NO
Colamine
Structure: H2N - CH2 - CH2 - OH
Chemical Properties
Molecular Weight: 61.08
Vapor Pressure: 6 mm at 60°C
Boiling Point: 170°C at 760 mm
Density: 1.0180 at 20°C/4°C
Octahol/Water Parti-
tion Coefficient: 1.71
Environmental Persistence
BOD: 75% of theoretical after 30 days at 20 C at 25 mg/ml
Total theoretical oxygen demand = 2.62 (gm/gm)
Atmospheric Reactivity:
Reacts with oxidizing materials
Safety Hazard: Fire-moderate
Physical State: Liquid
Vapor Density: 2.11
Melting Point: 10.3°C
Solubility: Infinite (H2O)
All-230
-------
Ethanolamine
PRODUCTION DATA
AnnuafU.S.
Production: 293 x 106 Ibs. (1973)
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Consumption: 266 x 10b Ibs. (1974)
Fraction of Pro-
duction Lost: 0.01S
TOXICITY DATA
Acute Toxicity
LDso
Dosage
2100mg/kg
981 mg/kg
2537 mg/kg
Animal
rat
rat
mouse
Chronic Toxicity
U.S. Occupational Standard: (ait) TWA: 3 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
Route
oral
intraperitoneal
subcutaneous
AII-231
-------
Ethion
CHEMICAL NAME
CAS Number: 563-12-2
Chemical Name: Phosphorodithioic acid, 5,5'-methylene O,O,O',O'-tetraethyl ester
Synonyms: 0,0,0',0'-Tetraethyl-S-S-methylene diphosphorodithioate
Tetiaethyl-S-S'-methylenedi(phosphorothiolothionate)
Ethyl methylene phosphorodithioate
Molecular
Formula:
S S
II . II
Structure: (C2H5O)2P - S - CH2 - S - P(OC2H5)2
Chemical Properties
Molecular Weight: 384.5 Physical State: Liquid
Vapor Pressure: Vapor Density:
Boiling Point: Melting Point: -13°C
Density: 1.220 at 20°C/4°C Solubility: Slightly (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Gradually oxidizes in air
Safety Hazard:
MI-232
-------
Annual U.S.
Production: 2.0 x 106 Ibs.
Fraction of
Dispersion:
1.0
Release Rate (million Ibs/yr): 2.0
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost: 0.015
Ethion
Acute Toxicity
TOXICITY DATA
Dosage Animal
13 mg/kg rat
62 mg/kg rat
26 mg/kg rat
55 mg/kg rat
35 mg/kg mouse
890 mg/kg rabbit
45 mg/kg wild bird
Non-lethal Acute Effects:
Central nervous system
_ TDLo 16 mg/kg
Blood effects^
TDLo 100 jig/kg
infant
human
Route
oral
skin
intraperitoneal
unreported
intraperitoneal
skin
oral
oral
oral
Chronic Toxicity
U.S. Occupational Standard:
EPA: Farm worker field re-entry
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AII-233
-------
Ethyl acetate
CHEMICAL NAME
CAS Number: 141-78-6
Chemical Name: Acetic acid, ethyl ester
Synonyms: Acetic ester
Ethylacetic ester
Ethyl etharate
Molecular
Formula: C4HgO2
Ethyl esters of acetic acid
O
Structure: CH3.- C
O - CH2 - CH3
Chemical Properties
Molecular Weight: 88.10
Vapor Pressure: 92.5 mm at 25°C
Boiling Point: 77.06°C at 760 mm
Density: 0.8946 at. 25°C/4°C
Octanol/Water Parti-
tion Coefficient: 2.68
Environmental Persistence
BOD: 69% of theoretical after 20 days'at 20°C
Total theoretical oxygen demand = 1.82 gm/gm
Physical State: Liquid
Vapor Density: 3.04
Melting Point: -83.578°C
Solubility: Soluble (89 gm/1 H2O)
Atmospheric Reactivity:
Safety Hazard:
All-234
-------
Ethyl acetate
PRODUCTION DATA
Annual U.S.
Production: 212.0 x 106 Ibs.
Fraction of
Dispersion: 0.91
Release Rate (million Ibs/yr): 196.1
Consumption: 212.0 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
LCLo
Dosage
5000 mg/kg
709 mg/kg
3000 mg/kg
4930 mg/kg
3000 mg/kg
1600 mg/kg
31 mg/m3 (1 hour)
Chronic Toxicity
U.S. Occupational Standard: (air) TWA : 400 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Irritating to mucous surfaces and eyes
Dermatitis
Congestion of liver and kidneys
Anemia, leucocytosis
Animal
rat
mouse
cat
rabbit
guinea pig
rat
mouse
TLV: 400 ppm
Route
subcutaneous
intraperitoneal
subcutaneous
oral
subcutaneous
inhalation
inhalation
AII-235
-------
Ethyl acetoacetate
CHEMICAL NAME
CAS Number: 141-97-9
Chemical Name: Acetoacetic acid, ethyl ester
Synonyms: 3-Oxo-butanoic acid, ethyl ester
Diacetic ether
Molecular
Formula: C6H10O3
O O
II II
Structure: CH3 - c - CH2 - C - 6 - CH2CH3
Chemical Properties
Molecular Weight: 130.15 Physical State: Liquid
Vapor Pressure: 1 mm at 28.5°C Vapor Density: 4.48
Boiling Point: 180.8°C Melting Point: <-80°C
Density: 1.0282 at 20°C/4°C Solubility: Very soluble (H2O)
Octanol/Water Parti-
tion Coefficient: 1.23
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
All-236
-------
Ethyl acetoacetate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 3980mg/kg rat oral
Non-lethal Acute Effects:
Local irritant to skin and mucous membranes
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-237
-------
Ethyl acrylate
CHEMICAL NAME
CAS Number: 140-88-5
Chemical Name: Acrylic acid, ethyl ester
Synonyms: Ethyl acrylate
Ethyl propenoate
Propenoic acid, ethyl ester
Molecular
Formula:
O
II
Structure: CH2 = CH - C - OCH2CH3
Chemical Properties
Molecular Weight: 100.13 Physical State: Liquid
Vapor Pressure: 38.5 mm at 25°C Vapor Density: 3.45
Boiling Point: 99.8°C Melting Point: -71.2°C
Density: 0.9234 at 20°C/4°C Solubility: Slightly soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-dangerous
Explosion-dangerous
AII-238
-------
Ethyl acrylate
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
Dosage
830 mg/kg
1950 mg/kg
420 mg/kg
2000 ppm (4 hours)
1204ppm (7 hours)
1204 ppm (7 hours)
Animal
rat
rabbit
rabbit
rat
rabbit
guinea pig
Route
oral
skin
oral
inhalation
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA: 25 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
TLV: 25ppm
Other Chronic Effects:
Irritation of gastrointestinal tract
Degenerative changes in cardiac, hepatic, renal, and splenic tissues
Skin and eye irritant
AII-239
-------
Ethyl alcohol
CHEMICAL NAME
CAS Number: 64-17-5
Chemical Name: Ethanol
Synonyms: Absolute ethanol
Anhydrous alcohol
Dehydrated alcohol
Molecular
Formula: C2H6O
Ethyl hydrate
Ethyl Hydroxide
Methyl caibinol
Alcohol
Structure: CH3CH2OH
Chemical Properties
Molecular Weight: 46.07
Vapor Pressure: 54.3 mm at 25°C
Boiling Point: 78.5°C
Density: 0.7893 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 0.38
Environmental Persistence
BOD: 84% at 20°C for 20 days
Total theoretical 2.10 gm/gm
Atmospheric Reactivity:
Reacts with oxidizing materials
Physical State: Liquid
Vapor Density: 1-59
Melting Point: -117.3°C
Solubility: Infinite (H2O)
Safety Hazard:
Fire—dangerous
Cxplosion-moderate
AII-240
-------
Ethyl alcohol
PRODUCTION DATA
Annual U.S.
Production: 1850.6 x 106 Ibs.
Fraction of
Dispersion: 0.35
Release Rate (million Ibs/yr)
Acute Toxicity
LDSO
LDL
-------
Ethylamine
CHEMICAL NAME
CAS Number: 75-04-7
Chemical Name: Ethanamine
Synonyms: Aminoethane
Monoethylamine
Molecular
Formula: C2H7N
Structure: CH3~- CH2- NH2
Chemical Properties
Molecular Weight: 45.08
Vapor Pressure: 1094.24 mm at 25°C
Boiling Point: 16.6° at 760 mm
Density: 0.6829 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: -0.27
Physical State: Liquid
Vapor Density:
Melting Point: -81°C
Solubility: Infinite (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-dangerous
AII-242
-------
Ethylamine
PRODUCTION DATA
Annual U.S.
Production: 45.9 x 106 Ibs.
Fraction of
Dispersion:
0.30
Consumption: 45.9 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
Release Rate (million Ibs/yr): 14.4
TOXICITY DATA
Acute Toxicity
LDSO
LDLo
390 mg/kg
400 mg/kg
3000 ppm (4 hours)
Non-lethal Acute Effects:
Irritation of eyes, skin, and respiratory tract
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 10 ppm
Carcinogenicity:
Animal
rabbit
rat
rat
Route
skin
oral
inhalation
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AII-243
-------
Ethyl sec-amyl ketone
CHEMICAL NAME
CAS Number: 6137-11-7
Chemical Name: 4-Methyl-3-heptanone
Synonyms: Ethyl sec-amyl ketone
Molecular
Formula: C8H16O
O
II
Structure: CH3 - CH2 - C - CH - CH2 - CH2 - CH3
CH,
Chemical Properties
Molecular Weight: 128.22 Physical State:
Vapor Pressure: Vapor Density:
Boiling Point: Melting Point:
Density: Solubility:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
All-244
-------
Ethyl sec-amyl ketone
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of . Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 3500mg/kg rat oral
3800 mg/kg mouse oral
2500 mg/kg guinea pig oral
3484 ppm (8 hours) rat inhalation
3484 ppm (8 hours) mouse inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA: 25 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-245
-------
Ethyl benzene
CHEMICAL NAME
CAS Number: 100-41-4
Chemical Name: Ethylbenzene
Synonyms: Ethylbenzol
Phenylethane
Molecular
Formula: C8H10
Structure:
Chemical Properties
Molecular Weight: 106.17 Physical State: Liquid
Vapor Pressure: 9.63 mm at 25°C Vapor Density: 3.66
Boiling Point: 136.2°C at 760 mm Melting Point: -94.97°C
Density: 0.8670 at 20°C/4°C Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient: 3.15
Environmental Persistence
BOD: 3% of theoretical after 5 days at 20°C
Total theoretical oxygen demand 3.16 gm/gm
Atmospheric Reactivity:
Occurs in atmosphere in small quantities
Unreactive to RO^ and O3
Reacts with oxidizing materials
Activity toward OH: t^ = 0.8 days, product is hydroxyethylbenzene
Safety Hazard:
Fire-moderate
AII-246
-------
Ethyl benzene
PRODUCTION DATA
Annual U.S.
Production:
Fraction of
Dispersion:
6920 x 106 Ibs..
(1975:4,008.2xl06lbs.)
0.02
Consumption: 6713 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.01
Release Rate (million Ibs/yr): 203.5
Acute Toxicity
LDSO
LCLo
Non-lethal Acute Effects:
Irritant
TC,
Lo
Narcosis
Dermatitis
TOXICITY DATA
Dosage Animal
3500 mg/kg rat
4000 ppm (4 hours) rat
1000 ppm ' guinea pig
1000 ppm
human
Route
oral
inhalation
inhalation
subcutaneous
Chronic Toxicity
U.S. Occupational Standard: TWA: 100 ppm
Carcinogenicity: Negative for inhalation and ingestion
Mutagenicity:
Teratogenicity: TLV: 100 ppm
Other Chronic Effects:
Blood disorders after repeated doses
Conjunctivitis and corneal erosion
Vertigo-2000 ppm (5 minutes)"
AII-247
-------
Ethyl bromide
CHEMICAL NAME
CAS Number: 74-96-4
Chemical Name: Bromoethane
Synonyms: Bromic ether
Hydrobromic ether
Molecular
Formula: C2H5Br
Physical State: Volatile liquid
Vapor Density: 3.76
Melting Point: -118.6°C
Solubility: Slightly soluble (H2O)
Structure: CH3CH2Br
Chemical Properties
Molecular Weight: 108.98
Vapor Pressure: 482.76 mm at 25°C
Boiling Point: 38.4°C
Density: 1.451 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 1.74
Environmental Persistence
BOD:
Atmospheric Reactivity:
Reacts with oxidizing materials to produce hydrobromic acid and bromide
Safety Hazard:
Explosion-moderate
Disaster hazard—dangerous, toxic fumes of bromine
AII-248
-------
Ethyl bromide
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
2200 ppm guinea pig inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA: 200 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 200 ppm
Other Chronic Effects:
Irritant to mucous membranes, especially lungs, liver, and kidney damage
AI1-249
-------
Ethyl butyl ketone
CHEMICAL NAME
CAS Number: 106-35-4
Chemical Name: 3-Heptanone
Synonyms: Ethyl butyl ketone
Molecular
Formula: C7H14O
Structure: CH3 - CH2 - C -
Chemical Properties
Molecular Weight: 114.19
Vapor Pressure: <1 mm at 20°C
Boiling Point: 148°C
Density: 0.8183at20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-moderate
Physical State: Liquid
Vapor Density: 3.93
Melting Point: -39°C
Solubility: Insoluble (H2O)
All-250
-------
Ethyl butyl ketone
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 2760mg/kg rat oral
LCL(j 2000 ppm (4 hours) rat inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA: SO ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 50 ppm
Other Chronic Effects:
AII-251
-------
Ethyl cellulose
CHEMICAL NAME
CAS Number: 9004-57-3
Chemical Name: Cellulose, ethyl ether
Synonyms:
Molecular
Formula:
Ethyl ether of cellulose
Cellulose ethyl
Cellulose ethylate
(Exact composition unknown or undetermined)
Structure: (Exact composition unknown or undetermined)
Chemical Properties
Molecular Weight:
Vapor Pressure:
Boiling Point:
Density: 1.07 to 1.18
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Solid
Vapor Density:
Melting Point: 240 to 255°C
Solubility: Insoluble (H20)
AII-252
-------
Ethyl cellulose
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-253
-------
Ethyl chloride
CHEMICAL NAME
CAS Number: 75-00-3
Chemical Name: Chloroethane
Synonyms: Muriatic acid
Hydrochloric ether
Molecular
Formula: C2H5C1
Structure: CH3CH2 - Cl
Chemical Properties
Molecular Weight: 64.52
Vapor Pressure: 20mmat21°C
Boiling Point: 12.27°Cat760rnm
Density: 0.8978 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Reacts with oxidizing materials
RO2: 1^ = 2000 years
OH: t% = 10 years
O3: t^= 1 year
Safety Hazard:
Fire-very dangerous
Explosion-very dangerous
Disaster hazard -very dangerous, toxic fumes of phosgene
Physical State: Liquid or gas
Vapor Density: 2.22
Melting Point: -136.4°C
Solubility: Slightly soluble
(0.574gm/100mlH2O)
All-254
-------
Ethyl chloride
PRODUCTION DATA
Annual U.S. -
Production: 660 x 106 Ibs. (1974)
Fraction of
Dispersion: O.OS
Release Rate (million Ibs/yr): 34.5
Consumption: 660 x 10 Ibs.
Fraction of Pro-
duction Lost: 0.01
Acute Toxicity
Non-lethal Acute Effects:
CNS
TCLO
Irritant to eyes
TOXICITY DATA
Dosage Animal
13,000 ppm
human
Route
inhalation
Kidney, heart, and liver damage
Subcutaneous tissue edema
Leucocytosis
Chronic Toxicity
U.S. Occupational Standard: (aii) TWA: 1000 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 1000 ppm
AII-255
-------
Ethyl chloroacetate
CHEMICAL NAME
CAS Number: 105-39-5
Chemical Name: Chloroacetic acid, ethyl ester
Synonyms: Ethylchloroethanoate
Qilpio^aceticjcid, ethyl ester
Ethyl chloroacetate
Molecular
Formula: C4H7C1O2
Structure: Cl - CH2 - C - OCH2CH3
II
O
Chemical Properties
Molecular Weight: 122.55
Vapor Pressure: 4.93 mm at 25°C
Boiling Point: 143.6°C
Density: 1.1585 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 4.3
Melting Point: -26°C
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-moderate
Disaster hazard—dangerous, toxic fumes—chlorides
• AII-256
-------
Ethyl chloroacetate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Non-lethal Acute Effects:
Local irritant to eyes
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-257
-------
Ethyl cyanoacetate
CHEMICAL NAME
CAS Number: 105-56-6
Chemical Name: Cyanoacetic acid, ethyl ester
Synonyms: Malonic ethyl ester nitrite
Molecular
Formula: CSH7NO2
O
II
Structure: N = C - CH2 - C - OCH2 - CH3
Chemical Properties
Molecular Weight: 113.1 Physical State: Liquid
Vapor Pressure: 67.8°C Vapor Density: 3.9
Boiling Point: 206°C Melting Point: -22.5°C
Density: 1.0654 at 20°C/4°C Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-slight
Disaster hazard-dangerous, toxic fumes of cyanides
AII-258
-------
Ethyl cyanoacetate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD5o 750 mg/kg mouse intraperitoneal
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-259
-------
Ethylene
CHEMICAL NAME
CAS Number: 74-85-1
Chemical Name: Ethylene
Synonyms: Acetene
Ethene
Molecular
Formula: C2H4
Structure: H2C = CH2
Chemical Properties
Molecular Weight: 28.06
Vapor Pressure: 34,200 mm at 0°C
Boiling Point: -103.9°C at 760 mm
Density: 0.99267 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Reported in ail in concentrations of 0.012 to 0.25 ppm
Activity: unresistive to ROj; ti^ with 0)3 = <4 hours
Activity toward OH: tvj = 1 day
Safety Hazard: Fire-dangerous
Explosion-moderate
Physical State: Gas
Vapor Density: 0.98
Melting Point: -169°C
Solubility: Insoluble (H2O)
AII-260
-------
Ethylene
PRODUCTION DATA
Annual U.S.
Production: 20,852.1 x 106 Ibs. Consumption: 20,852.1 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 0.01 duction Lost: 0.015
Release Rate (million Ibs/yr): 521.3
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Paralysis at high concentrations
Malfunctions of heart
Depressed activity of sympathetic ganglion of upper neck (cat)
Increased blood coagulation time (mouse)
. Disturbances of the electrical activity of the brain (dog)
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects: Lung inflamation; histopathological changes in liver and cerebellum (rabbit);
peripheral leucopenia; reduced cellularity of the bone marrow, hypertension, inhibition of
chlolinesterase activity, disruption of subordination chronaxy (rat).
AII-261
-------
Ethylene carbonate
CHEMICAL NAME
CAS Number: 96-49-1
Chemical Name: l,3-Dioxolan-2-one
Synonyms: Glycol carbonate
Dioxolone-2
Molecular
Formula: C3H4O3
Structure:
-0\
Vo
o
I/
Chemical Properties
Molecular Weight: 88.06 Physical State: Solid
Vapor Pressure: 0.01 mm at 20°C Vapor Density: 3.04
Boiling Point: 248°C at 760 nun Melting Point: 39 to 40°C
Density: 1.322 at 39°C/4°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-slight
AII-262
-------
Ethylene carbonate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: auction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-263
-------
Ethylene chlorohydrin
CHEMICAL NAME
CAS Number: 107-07-3
Chemical Name: 2-Chloroethanol
Synonyms: Ethylene chlorohydrin
(}-Chloroethyl alcohol
Glycol chlorohydrin
Molecular
Formula: C2H5ao
Structure: Cl - CH2 - CH2OH
Chemical Properties
Molecular Weight: 80.52 Physical State: Liquid
Vapor Pressure: 7.65 mm at 25°C Vapor Density: 2.78
Boiling Point: ~128^~atT~60mm Melting Point: -67.5°C
Density: 1.2003 at 20°C/4°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
Disaster hazard-dangerous-toxic fumes-phosgene
AII-264
-------
Ethylene chlorohydrin
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LD50 5 80 mg/kg
84 mg/kg
81 mg/kg
81 mg/kg
56 mg/kg
67 mg/kg
110 mg/kg
71 mg/kg
Ingestion has caused human death
LDLo
LCSO
LCLo
Non-lethal Acute Effects:
Skin-TDLo
Nausa
Irritation of eyes
Convulsions
40 mg/kg
1450 mg/kg
100 mg/kg
70 mg/kg
250 mg/kg
385 mg/m3
32 ppm (4 hours)
3000mg/m3(112minu
5000 mg/kg
Animal
rat
rat
mouse
mouse
rabbit
rabbit
guinea pig
guinea pig
rat
mouse
rabbit
guinea pig
frog
mouse
rat
tes) guinea pig
human
Chronic Toxicity
U.S. Occupational Standard: (air) 5 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Route
oral
subcutaneous
oral
intraperitoneal
skin
intraperitoneal
oral
intraperitoneal
intraperitoneal
skin
intravenous
skin
subcutaneous
inhalation
inhalation
inhalation
skin
TLV: 5 ppm (skin)
AII-265
-------
Ethylenediamine
CHEMICAL NAME
CAS Number: 107-15-3
Chemical Name: Ethylenediamine
Synonyms: 1,2-Ethanediamine
1,2-Diaminoe thane
Molecular
Formula: C2H8N2
Structure: H2N - CH2 - CH2 - NH2
Chemical Properties
Molecular Weight: 60.10
Vapor Pressure: 13.04 mm at 25°C
Boiling Point: 116.5°C at 760 mm
Density: 0.8994 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD: 70% of theoretical after 20 days at 20°C
Total theoretical oxygen demand = 3.7 gm/gm
Atmospheric Reactivity: Reacts with oxidizing materials
Physical State: Liquid
Vapor Density: 2.07
Melting Point: 8.5°C
Solubility: Very soluble (H2O)
Safety Hazard: Fire-moderate
AII-266
-------
Ethylenediamine
PRODUCTION DATA
Annual U.S.
Production: 54.4 x 106 Ibs.
Fraction of
Dispersion: 0.50
Release Rate (million Ibs/yr): 22.5
Consumption: 43.3 x 10 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
Non-lethal Acute Effects:
Irritant
TCLo
Dosage
760 mg/kg
424 mg/kg
730 mg/kg
470 mg/kg
4000 ppm (8 hours)
Animal
rat
mouse
rabbit
guinea pig
rat
200 ppm
human
Route
oral
subcutaneous
skin
oral
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 10 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects: Allergen
Dermatitis
Asthmatic
TLV: 10ppm
AII-267
-------
Ethylene dibromide
CHEMICAL NAME
CAS Number: 106-93-4
Chemical Name: 1,2-Dibromoethane
Synonyms: Ethylene dibromide
Glycol dibiomide
EDB
Molecular
Formula: C2H4Br2
H H
Structure: Br
Chemical Properties
Molecular Weight: 187.88
Vapor Pressure: 14.54 mm at 25°C
Boiling Point: 131.36°Cat 760 mm
Density: 2.1707 at 25°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Photochemical degradation: decomposes
Physical State: Heavy liquid
Vapor Density: 6.48
Melting Point: 9?79°C~
Solubnity: Slightly (H2O)
(0.431gm/100mlat30°C)
Safety Hazard:
AII-268
-------
Ethylene dibromide
PRODUCTION DATA
Annual U.S.
Production: 315.5 x 106 Ibs.
Fraction of
Dispersion: 0.95
Release Rate (million Ibs/yr): 304.4
Consumption: 315.5 x 106 Ibs.
Fraction of Pro-
duction Lost:
0.015
TOXICITY DATA
Acute Toxicity
Dosage
140 mg/kg
146 mg/kg
55 mg/kg
300 mg/kg
110 mg/kg
79 mg/kg
250 mg/kg
400 ppm (2 hours)
6425 ppm (1 hour)
400 ppm (3 hours)
Animal
rat
mouse
rabbit
rabbit
guinea pig
chicken
mouse
rat
rabbit
guinea pig
Route
oral
unreported
oral
skin
oral
oral
oral
inhalation
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air): TWA 20 ppm
ceiling 30 ppm
peak 50 ppm/5 mins/8 hours
Carcinogenicity: Positive, 10 week incubation, mouse
Mutagenicity: Positive in bacteria
Teratogenicity:
TLV:
Other Chronic Effects:
Abnormal sperm
Reduced sperm count
Skin irritation and blisters
Lung stimulation
AII-269
-------
Ethylene dichloride
CHEMICAL NAME
CAS Number: 107-06-2
Chemical Name: 1,2-Dichloroethane
Synonyms: Ethylene dichloride
Ethylene chloride
Molecular
Formula: C2H4C12
Structure: Cl - CH2 - CH2 - Cl
Chemical Properties
Molecular Weight: 99.0
Vapor Pressure: 84.42 mm at 25°C
Boiling Point: 83.5°C at 760 mm
Density: 1.257 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Fire-dangerous
Explosion-moderate
Physical State: Liquid
Vapor Density: 3.35
Melting Point: -35.5°C
Solubility: Slightly soluble (H2O)
(0.43 gm/~100 ml)
AII-270
-------
Ethylene dichloride
PRODUCTION DATA
Annual U.S. . _
Production: 9, 293 x 106 Ibs. (1973)
Fraction of
Dispersion: 0.05
Release Ratal million Ibs/yr): 540.2
Consumption: ca. 8,921.3 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LDSO
LCLo
Non-lethal Acute Effects:
Central nervous system
TCLo
Chronic Toxicity
TOXICITY DATA
Animal
860 mg/kg rabbit
680 mg/kg rat
845 mg/kg human
600 mg/kg rat
500 mg/kg rat
600 mg/kg mouse
250 mg/kg mouse
380 mg/kg mouse
2000 mg/kg dog
175 mg/kg dog
1200 mg/kg rabbit
1000 ppm (4 hours) rat
5000 mg/m3 (2 hours) mouse
3000 ppm (7 hours) rabbit
3000 ppm (7 hours) pig
1500 ppm (7 hours) guinea pig
4000 ppm (hour) human
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
^air) TWA 50 ppm
Ceiling 100 ppm
Peak 200 ppm/5 minute/3 hours
TLV:
Route
oral
oral
oral
intraperitoneal
subcutaneous
oral
intraperitoneal
subcutaneous
oral
intravenous
subcutaneous
inhalation
inhalation
inhalation
inhalation
inhalation
inhalation
AII-271
-------
Ethylene glycol
CHEMICAL NAME
CAS Number: 107-21-1
Chemical Name: Ethylene glycol
Synonyms: 1,2-Ethyanediol
Ethylene alcohol
Molecular .
Formula: C2H6O2
Structure: HO - CH2 - CH2 - OH
Chemical Properties
Molecular Weight: 62.1 Physical State: Liquid
Vapor Pressure: 0.05 mm at 20°C Vapor Density: 2.14
Boiling Point: 198°C at 760 mm Melting Point: -11.5°C
Density: 1.1088 at 20°C/4°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient: -1-88
Environmental Persistence
BOD: 13% Theoretical
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-slight
Explosion-moderate
AII-272
-------
Ethylene glycol
PRODUCTION DATA
Annual U.S.
Production: 3,761.1 x 106 Ibs. Consumption: 3,242 x 106 Ibs. (1974)
Fraction of Fraction of Pro-
Dispersion: 0.70 duction Lost: 0.01S
Release Rate (million Ibs/yr): 2,526.3
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 2000mg/kg cat oral
6610mg/kg guinea pig oral
LDLo 1500 mg/kg human oral
2700 mg/kg mouse skin
1000 mg/kg rabbit intraperitoneal
Non-lethal Acute Effects:
CNS stimulation followed by depression, if ingested
Kidney damage
Very toxic in particulate form
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Neoplastic effects: TD]_,0 4 gm/kg mouse skin
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects: Slight irritant
AII-273
-------
Ethylene glycol, diacetate
CHEMICAL NAME
CAS Number: 111-55-7
Chemical Name: Ethylene glycol, diacetate
Synonyms: Ethylene diacetate
Gylcol diacetate
Molecular
Formula: C6H10O4
Structure:
O
II
CH2 - O - C - CH3
I
CH2 - O - C - CH3
II
O
Chemical Properties
Molecular Weight: 146.14
Vapor Pressure: 1 mm at 38.3°C
Boiling Point: 190°C at 760 nun
Density: 1.1063 at 20° C/20°C
Octanol/Water Parti-
tion Coefficient: 0.38
Physical State: Liquid
Vapor Density: 5.04
Melting Point: -31.0°C
Solubility: Very soluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing material
Safety Hazard: Fire-moderate
AII-274
-------
Ethylene glycol, diacetate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD5o 1070 mg/kg mouse intarpeiitoneal
.4940 mg/kg guinea pig oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-275
-------
Ethylene glycol, dibutyl ether
CHEMICAL NAME
CAS Number: 112-48-1
Chemical Name: 1,2-Dibutoxyethane
Synonyms: Dibutyl cellosolve
Molecular
Formula:
Structure: CH3 - (CH2)3 - O - CH2 - CH2 - O - (CH2)3 - CH3
Chemical Properties
Molecular Weight: 174.29
Vapor Pressure: 0.09 mm at 20°C
Boiling Point: 203.1°C at 760 mm
Density: 0.8374 at 20°C/20°C
Octanol/Water Parti-
. tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: -69.1°C
Solubility: Slightly soluble (H2O)
AII-276
-------
Ethylene glycol, dibutyl ether
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-277
-------
Ethylene glycol, diethyl ether
CHEMICAL NAME
CAS Number: 16484-86-9
Chemical Name: Ethylene glycol, diethyl ether
Synonyms: 1,2-Diethoxyethane
Diethyl cellosolve
Molecular
Formula: C6H14O2
Structure:
Chemical Properties
Molecular Weight: 118.18
Vapor Pressure: 9.4 mm at 20°C
Boiling Point: 123.5°C at 760 mm
Density: 0.8484 at 20°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: -74°C
Solubility: Insoluble (H2O)
AII-278
-------
Ethylene glycol, diethyl ether
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 4390mg/kg rat oral
2440mg/kg guinea pig oral
9000 ppm (14 hours) rat inhalation
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-279
-------
Ethylene glycol, dimethyl ether
CHEMICAL NAME
CAS Number: 534-15-6
Chemical Name: Dimethyl acetal acetaldehyde
Synonyms: Ethylene glycol, dimethyl ether
GDME
1,2-Dimethoxyethane
Molecular
Formula: C4H10O2
Structure: CH3 - O - CH2CH2 - O - CH3
Chemical Properties
Molecular Weight: 90.14 Physical State: Liquid
Vapor Pressure: 77.52 mm at 25°C Vapor Density: 3.11
Boiling Point: 83 to 84°C at 760 mm Melting Point: -58°C
Density: 0.8629 at 20°C/4°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-dangerous
Explosion-dangerous
AII-280
-------
Ethylehe glycol, dimethyl ether
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TOXICITY DATA
Animal
TLV:
Route
AII-281
-------
Ethylene glycol, monoacetate
CHEMICAL NAME
CAS Number: 542-59-6
Chemical Name: Ethylene glycol, monoacetate
Synonyms: Glycol monoacetate
1,2-Ethanediol, monoacetate
Hydroxyethyl acetate
Molecular
Formula: C4HgO3
O
II
Structure: CH3 - C - OCH2CH2OH
Chemical Properties
Molecular Weight: 104.10 Physical State: Liquid
Vapor Pressure: Vapor Density: 3.59
Boiling Point: 181 to 182°C Melting Point:
Density: 1.108 at 15°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-282
-------
Ethylene glycol, monoacetate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
1310mg/kg mouse intraperitoneal
3800 mg/kg guinea pig oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-283
-------
Ethylene glycol, monobutyl ether
CHEMICAL NAME
CAS Number: 111-76-2
Chemical Name: 2-Butoxyethanol
Synonyms: Ethylene glycol, monobutyl ether
Butyl cellosolve
Molecular
Formula:
Structure: CH3(CH2)3 - O - CH2CH2OH
Chemical Properties
Molecular Weight: 118.17 Physical State: Liquid
Vapor Pressure: 0.76 mm at 20°C Vapor Density: 4.07
Boiling Point: 171.2°C Melting Point:
Density: 0.9027 at 20°C/4°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Fire-moderate
AII-284
-------
Ethylene glycol, monobutyl ether
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
LCSO
Non-lethal Acute Effects:
Irritant
TDLo
Dosage
1480 mg/kg
550 mg/kg
340 mg/kg
1230 mg/kg
536 mg/kg
1130 mg/kg
320 mg/kg
560 mg/kg
280 mg/kg
1200 mg/kg
230 mg/kg
700 ppm (2 hours)
500 ppm (4 hours)
195 ppm (8 hours)
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 50 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
rat
rat
mouse
mouse
mouse
rabbit
rabbit
rabbit
guinea pig
guinea pig
mouse
rat
human
Route
oral
intraperitoneal
intravenous
oral
intraperitoneal
intravenous
oral
skin
intravenous
oral
skin
inhalation
inhalation
inhalation
TLV: 50 ppm (skin)
All-285
-------
Ethylene glycol, monoethyl ether
CHEMICAL NAME
CAS Number: 110-80-5
Chemical Name: 2-Ethoxyethanol
Synonyms: Cellosolve solvent
Ethylene glycol, monoethyl ether
Molecular
Formula: C4H10O2
Structure: CH3 CH2OCH2CH2OH
Chemical Properties
Molecular Weight: 90.12
Vapor Pressure: 3.8 mm at 20°C
Boiling Point: 135.1°C
Density: 0.9360 at 15°C/15°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 3.10
Melting Point: <37.7°C (pour point)
Solubility: Soluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
Explosion-moderate
AII-286
-------
Ethylene glycol, monoethyl ether
PRODUCTION DATA
Annual U.S.
Production: 205.4 x 106 Ibs
Fraction of
Dispersion: 0.97
Release Rate (million Ibs/yr): 197.5
Consumption: 200.4 x 106 Ibs.
Fraction of Pro-
duction Lost: 6.015
TOXICITY DATA
Acute Toxicity
LD50
LC
Lo
3000 mg/kg
4300 mg/kg
1710 mg/kg
3100 mg/kg
1400 mg/kg
4000 ppm (4 hours)
1820ppm
Animal
rat
mouse
mouse
rabbit
guinea pig
rat
mouse
Route
oral
oral
intraperitoneal
oral
oral
inhalation
inhalation
Non-lethal Acute Effects:
Local irritant
Exposure to vapor produces congestion and edema of the lungs and
congestion of the kidney
Eye irritation observed in humans
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 200 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 200 ppm (skin)
AII-287
-------
Ethylene glycol, monoethyl ether acetate
CHEMICAL NAME
CAS Number: 111-15-9
Chemical Name: 2-Ethoxyethanol acetate
Synonyms: Ethylene glycol, monoethyl ether acetate
Molecular
Formula: C6Hi2O3
O
II
Structure: CH3 - C - OCH2 - CH2 - OCH2CH3
Chemical Properties
Molecular Weight: 132.17 Physical State: Liquid
Vapor Pressure: 1.2mmat20°C Vapor Density: 4.72
Boiling Point: 156.3°C Melting Point: -61.7°C
Density: 0.9748 at 20°C/20°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Fire-moderate
Explosion-moderate
AII-288
-------
Ethylene glycol, monoethyl ether acetate
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LD50
LC
Lo
1420 mg/kg
1910mg/kg
1500 ppm (4 hours)
Animal
mouse
guinea pig
rat
Route
intraperitoneal
oral
inhalation
Non-lethal Acute Effects:
Irritation of eyes and respiratory tract
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 100 ppm
AII-289
-------
Ethylene glycol, monohexyl ether
CHEMICAL NAME
CAS Number: 112-25-4
Chemical Name: 2-(Hexyloxy) ethanol
Synonyms: Ethylene glycol, monohexyl ether
Hexyl cellosolve
Molecular
Formula: C8H,8O2
Structure: HO - CH2 - CH2-O - (CH2)5CH3
Chemical Properties
Molecular Weight: 146.22 Physical State: Liquid
Vapor Pressure: 0.05 mm at 20°C Vapor Density: 5.04
Boiling Point: Melting Point: -50.1°C
Density: 0.8894 at 20°C/20°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-290
-------
Ethylene glycol, monohexyl ether
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 1480mg/kg rat oral
896 mg/kg rabbit skin
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-291
-------
Ethylene glycol, monomethyl ether
CHEMICAL NAME
CAS Number: 109-86-4
Chemical Name: 2-Methoxyethanol
Synonyms: Ethylene glycol, monomethyl ether Ethoxyacetate
Cellosolve acetate
Methyl cellosolve
Molecular
Formula: C3H8O2
Structure: CH3OCH2CH2OH
Chemical Properties
Molecular Weight: 76.09 Physical State: Liquid
Vapor Pressure: 6.2at20°C Vapor Density: 2.62
Boiling Point: 124.5°C Melting Point: -81.5°C
Density: 0.9660 at 20°C/4°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-292
-------
Ethylene glycol, monomethyl ether
PRODUCTION DATA
Annual U.S.
Production: 137.4 x 106 Ibs. (1968)
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Consumption:
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LCSO
LCLo
Non-lethal Acute Effects:
Central nervous system
TCLo
25 ppm
TOXICITY DATA
Animal
rat
rat
rabbit
rabbit
guinea pig
rabbit
rat
human
2460 mg/kg
2140 mg/kg
890 mg/kg
1340 mg/kg
950 mg/kg
1340 mg/kg
2000 ppm (4 hours)
Route
oral
intravenous
oral
skin
oral
inhalation
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
TLV: 25 ppm (skin)
Other Chronic Effects:
Disturbances of hemopoietic system with or without neurological signs or symptoms
Severe aplastic anemia with tremors and marked mental dullness |
Reduction of number of blood platelets and macrocytic anemia
AII-293
-------
Ethylene glycol, monomethyl ether acetate
CHEMICAL NAME
CAS Number: 110-49-6
Chemical Name: 2-Methoxyethanol acetate
Synonyms: Ethylene glycol, monomethyl ether acetate
Cellosolve acetate
Molecular
Formula:
O
II
Structure: CH3 - C - OCH2CH2OCH3
Chemical Properties
Molecular Weight: 118.13 Physical State: Liquid
Vapor Pressure: 1.2mmat20°C Vapor Density: 4.07
Boiling Point: 145°C Melting Point: -65.1°C
Density: 1.0067 at 20°C/20°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-294
-------
Ethylene glycol, monomethyl ether acetate
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LD50
LCLo
3390 mg/kg
1250 mg/kg
7000 ppm (4 hours)
Animal
rat
guinea pig
rat
Non-lethal Acute Effects:
Irritation of eyes and respiratory tract
Nausea and vomiting
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 25 ppm (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
fLV: 25ppm
Route
oral
oral
inhalation
AII-295
-------
Ethylene glycol, monooctyl ether
CHEMICAL NAME
CAS Number: 10020-43-6
Chemical Name: 2-(Octyloxy)ethanol
Synonyms: Ethylene glycol monooctyl ether
Molecular
Formula: Ci0H22O2
Structure: CH3(CH2)? - O - CH2 - CH2 - OH
Chemical Properties
Molecular Weight: 174.28 Physical State: Liquid
Vapor Pressure: 0.02 mm at 20 C Vapor Density:
Boiling Point: 228.3°C Melting Point:
Density: 0.8859 at 20°C Solubility:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-slight
Explosion-moderate
AII-296
-------
Ethylene glycol, monooctyl ether
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-297
-------
Ethylene glycol, monophenyl ether
CHEMICAL NAME
CAS Number: 122-99-6
Chemical Name: 2-Phenoxyethanol
Synonyms: Ethylene glycol, monophenyl ether
Phenyl cellosolve
Molecular
Formula:
Structure:
O - CH2CH2 - OH
Chemical Properties
Molecular Weight: 138.2
Vapor Pressure: <0.01 mm at 20°C
Boiling Point: 244.9°C
Density: 1.1094 at 20°C/20°C
Octanol/Water Parti-
tion Coefficient: 1.16
Physical State: Liquid
Vapor Density: 4.76
Melting Point: 14°C
Solubility: Soluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-slight
Explosion-moderate
AII-298
-------
Ethylene glycol, monophenyl ether
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity , Dosage Animal Route
LDSO 1260mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-299
-------
Ethylene glycol, monopropyl ether
CHEMICAL NAME
CAS Number: 2807-30-9
Chemical Name: 2-Propoxyethanol
Synonyms: Propyl cellosolve
Ethylene glycol monopropyl ether
Molecular
Formula: CsHi2O2
Structure: HO - CH2 - CH2 - O - CH2 - CH2 - CH3
Chemical Properties
Molecular Weight: 104.14
Vapor Pressure:
Boiling Point: 150°C at 743 mm
Density: 0.9112 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-moderate
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility: Soluble (H2O)
AII-300
-------
Ethylene glycol, monopropyl ether
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 4890mg/kg rat oral
940 mg/kg rabbit skin
LCLo 2000 ppm (4 hours) rat inhalation
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-301
-------
Ethyleneimine
CHEMICAL NAME
CAS Number: 151-56-4
Chemical Name: Ethylenimine
Synonyms: Aziridine
Molecular
Formula: C2H5N
Structure:
N
I
H
Chemical Properties
Molecular Weight: 43.07
Vapor Pressure: 160 mm at 20°C
Boiling Point: 56°Cat756mm
Density: 0.832 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard: Fire-dangerous
Explosion-dangerous
Physical State: Liquid
Vapor Density: 1.48
Melting Point: -78°C
Solubility: Infinitely soluble (H2O)
AII-302
-------
Ethyleneimine
Annual U.S.
Production:
5 x 10° Ibs.
PRODUCTION DATA
Consumption:
Fraction of
Dispersion: 0.01
Release Rate (million Ibs/yr): 0.08
Fraction of Pro-
duction Lost: °-015
TOXICITY DATA
Acute Toxicity
Dosage
15 mg/kg
3800 mg/kg
15 mg/kg
14 mg/kg
25 ppm (8 hours)
25 ppm (8 hours)
400 mg/m3
2200 ppm (10 mins)
LCSO
Non-lethal Acute Effects:
Skin irritation
Skin sensitization
Necrosis of cornea
Nausea and vomiting
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 1 mg/m3 (skin)
Animal
rat
rat
mouse
guinea pig
rat
guinea pig
mouse
rat
Route
oral
intiaperitoneal
unreported
skin
inhalation
inhalation
inhalation
inhalation
Carcinogenicity:
TDLo
Mutagenicity:
TDLo
Teratogenicity:
Other Chronic Effects:
20 mg/kg (67 days) rat
235 mg/kg (76 weeks) mouse
subcutaneous
oral
6 mg/kg
mouse
JLV:
Odor perception: 2 ppm
intraperitoneal
AII-303
-------
Ethylene oxide
CHEMICAL NAME
CAS Number: 75-21-8
Chemical Name: Ethylene oxide
Synonyms: 1,2-Epoxyethane
Oxiiane
Molecular
Formula: C2H4O
Structure:
Chemical Properties
Molecular Weight: 44.05 Physical State: Gas
Vapor Pressure: 1475 mm at 25°C Vapor Density: 1.52
Boiling Point: 13.5°Cat 746 mm Melting Point: -111.3°C
Density: 0.8711 at 20°C/20°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD: 31% of theoretical after 10 days at 70°C at 100 mg/ml
Total theoretical oxygen demand = 1.82 gm/gm
Atmospheric Reactivity:
Unreactive to ROj or Oj
Activity towards OH: ti^ = 1.6 days
Reacts with oxidizing materials
Hydrolyzes rapidly: ti^ = 2.5 days at pH 7
Safety Hazard: Fire-dangerous
Explosion-severe
AII-304
-------
Ethylene oxide
PRODUCTION DATA
Annual U.S.
Production: 3,961.8 x 106 Ibs.
Fraction of
Dispersion: 0.01
Release Rate (million Ibs/yr): 98.8
Consumption: 3,934.0 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LDSO
LC
so
Animal
rat
guinea pig
lat
mouse
dog
Dosage
330 mg/kg
270 mg/kg
1462 ppm (4 hours)
836 ppm (4 hours)
960 ppm (4 hours)
LCLo 7000 ppm (150 minutes) guinea pig
LC 15,000 to 10,000 ppm (air)
Non-lethal Acute Effects:
Irritant to eyes and mucous membranes
Pulmonary edema at high concentrations
Reduced motor response-CNS damage
Skin burns
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 50 ppm
Carcinogenicity: Positive carcinogen in mice-various tumors-oral
Mutageniciry:
Increased chromosomal aberrations
30 mg/rh3
Teratogenicity:
Other Chronic Effects:
mammal <
TLV: 50ppm
Route
oral
oral
inhalation
inhalation
inhalation
inhalation
inhalation
inhalation
AII-305
-------
Ethyl ether
CHEMICAL NAME
CAS Number: 60-29-7
Chemical Name: Ethyl ether
Synonyms: Ether
Ethyl oxide
Molecular
Formula: C4Hi0O
Anaesthesia ethei
Diethyl ether
l,l'-Oxybis-e thane
Structure: CH3 - CH2 - O - CH2 - CH3
Chemical Properties
Molecular Weight: 74.12
Vapor Pressure: 442 mm at 20°C
Boiling Point: 34.5°C
Density: 0.7135 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 0.93
Physical State: Volatile liquid
Vapor Density: 2.56
Melting Point: -116.2°C
Solubility: Slightly soluble (H2O)
Environmental Persistence
BOD: 1% theoretical
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-dangerous
Explosion-severe
All-306
-------
Ethyl ether
PRODUCTION DATA
Annual U.S.
Production: 103.2 x 10* Ibs. (1969) Consumption: 102. x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 0.50 duction Lost: 0.015
Release Rate (million Ibs/yr): 35.7
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 1700 mg/kg rat oral
LDLo 2000 mg/kg rat intraperitoneal
Chronic Toxicity
U.S. Occupational Standard: (air) TWA: 400 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 400 ppm
Other Chronic Effects:
CNS depressant
All-307
-------
Ethyl formate
CHEMICAL NAME
CAS Number: 109-944
Chemical Name: Formic acid, ethyl ester
Synonyms: Formic ether
Ethyl formic ester
Ethyl methanoate
Molecular
Formula: C3H6O2
O
Structure: H - C - OCH2CH3
Chemical Properties
Molecular Weight: 74.08
Vapor Pressure: 258.48 mm at 25°C
Boiling Point: 54.5°C at 760 mm
Density: 0.9236 at 20°C/20°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 2.55
Melting Point: ^8oT0cf
Solubility: Soluble (H2O)
Environmental Persistence
BOD: 30% of theoretical after 10 days
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-dangerous
Explosion-severe
All-308
-------
Ethyl formate
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LD50
LD
Lo
Dosage
1850 mg/kg
2070 mg/kg
1100 mg/kg
8000 ppm (4 hours)
Animal
rat
rabbit
guinea pig
rat
Route
oral
oral
oral
inhalation
Non-lethal Acute Effects:
Irritant to_skin and mucous membranes
Narcotic at high concentrations
TCT
"Lo
" 330 ppm
human
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA: 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: lOOppm
Other Chronic Effects:
All-309
-------
Ethylhexanol
CHEMICAL NAME
CAS Number: 104-76-7
Chemical Name: 2-Ethyl-l-hexanol
Synonyms: Ethylhexanol
2-Ethylhexyl alcohol
Octyl alcohol
Molecular
Formula:
CH3
I
CH2
I
Structure: CH3 - CH2 - CH2 - CH2 - CH - CH2OH
Chemical Properties
Molecular Weight: 130.23 Physical State: Liquid
Vapor Pressure: 1 mm at 50°C Vapor Density: 6.35
Boiling Point: 130°Cat50mm Melting Point: <-76°C
Density: 0.8859 at 20°C/20°C Solubility: Slightly (1.16 gm/!H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD: 86% of theoretical after 20 days at 20°C at 10 mg/ml
Total theoretical oxygen demand =2.95 gm/gm
Atmospheric Reactivity:
Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AII-310
-------
Ethylhexanol
PRODUCTION DATA
Annual U.S.
Production: 264.7 x 106 Ibs. (1975)
Fraction of
Dispersion: 0.15
Release Rate (million Ibs/yr): 79.0
Consumption: 310.0 x 106 Ibs. (1975)
Fraction of Pro-
duction Lost: 0.015
TOXlfclTY DATA
Acute Toxicity
LDSO
LD
Lo
3200 mg/kg
"7380-mg/kg -
3200 mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
rabbit
mouse
TLV:
Route
oral
skin
oral
AII-311
-------
Ethylidene chloride
CHEMICAL NAME
CAS Number: 75-34-3
Chemibal Name: IJ-Dichloioethane
Synonyms: Ethylidene chloride
Ethylidene dichloiide
Chlorinated hydrochloric ether
Molecular
Formula: C2H4C12
H
' I
Structure: CH3 - C - Cl
J_
a
Chemical Properties
Molecular Weight: 98.96
Vapor Pressure: 230 mm at 25°C
Boiling Point: 57.3°C at 760 mm
Density: 1.174 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Fire-dangerous
Explosion-moderate
Physical State: Liquid
Vapor Density: 3.44
Melting Point: -98°C
Solubility: Sparingly (H2O)
AIJ-312
-------
Ethylidene chloride
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of . Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 725 mg/kg rat oral
Non-lethal Acute Effects:
Liver injury
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
All-313
-------
Ethyl mercaptan
CHEMICAL NAME
CAS Number: 75-08-1
Chemical Name: Ethanethiol
Synonyms: Ethyl hydtosulfide
Ethyl thioalcohol
Ethyl sulfhydrate
Molecular
Formula: C2H6S
Structure: CH3 - CH2 - SH
Chemical Properties
Molecular Weight: 62.13
Vapor Pressure: 551.91 mm at 25°C
Boiling Point: 35°Cat760mm
Density: 0.83907 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Fire-dangerous
Explosion-moderate
Physical State: Liquid
Vapor Density: 2.14
Melting Point: -144.4°C
Solubility: Slightly soluble (H2O)
AII-314
-------
Ethyl mercaptan
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
LCSO
Non-lethal Acute Effects:
CNS irritant
TCLo
682 mg/kg
450 mg/kg
4420 ppm (4 hours)
2770 ppm
4 ppm
Animal
rat
rat
rat
mouse
human
Route
oral
intraperitoneal
inhalation
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) Ceiling level: 10 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
All-315
-------
Ethyl methanesulfonate
CHEMICAL NAME
CAS Number:
Chemical Name:
62-50-0
Methanesulfonic acid, ethyl ester
Synonyms: Ethyl ester of methylsulfonic acid
Methylsulfonic acid, ethyl ester
Molecular
Formula: C3H8O3S
O
II
Structure: CH3 - S - OCH2CH3
II .
O
Chemical Properties
Molecular Weight: 124.17
Vapor Pressure:
Boiling Point: 159°C
Density: 1.187 at 25°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: -37°C
Solubility: Very soluble (H2O)
AII-316
-------
Ethyl methanesulfonate
PRODUCTION DATA
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Not produced commercially
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
Dosage
200 mg/kg
Animal
mouse
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
TDLo
Neoplasm
36 mg/kg
mouse
Mutagenicity:
TDLo
Teratogenicity:
TDLo
Other Chronic Effects:
100 mg/kg
83 mg/kg
300 mg/kg
380 mg/kg
200 mg/kg (13 days)
rat
mouse
rat
mouse
TLV:
pregnant rat
Route
intraperitoneal
parenteral
intraperitoneal
subcutaneous
intraperitoneal
intraperitoneal
intraperitoneal
AII-317
-------
N-Ethylmorpholine
CHEMICAL NAME
CAS Number: 100-74-3
Chemical Name: 4-Ethylmorpholine
Synonyms: N-Ethylmorpholine
Molecular
Formula: C6H13NO
CH2CH3
Structure:
Chemical Properties
Molecular Weight: 115.2
Vapor Pressure:
Boiling Point: 138°C
Density: 0.8996 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Fire-moderate
Physical State: Liquid
Vapor Density: 4.00
Melting Point: -63°C
Solubility: Infinite (H2O)
AII-318
-------
N-Ethylmorpholine
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LD50
LCLo
Dosage
1780mg/kg
2000 ppm (4 hours)
Non-lethal Acute Effects:
Irritant to mucous membranes, eyes
100 ppm
Animal
rat
rat
human
Route
oral
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 20 ppm (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 20 ppm (skin)
AII-319
-------
Ethyl naphthalene
CHEMICAL NAME
CAS Number: 1127-76-0
Chemical Name: 1-Ethyl naphthalene
Synonyms: Ethyl naphthalene
Molecular
Formula: C12Hi2
CH2CH3
Structure:
Chemical Properties
Molecular Weight: 156.23
Vapor Pressure: 1 mm at 20.0°C
Boiling Point: 258°C at 760 mm
Density: 1.0082 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: -13.88°C
Solubility: Insoluble (H2O)
AII-320
-------
Ethyl naphthalene
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
5000mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AII-321
-------
Ethyl oxalate
CHEMICAL NAME
CAS Number: 95-92-1
Chemical Name: Oxalic acid, diethyl ester
Synonyms: Ethyl oxalate Oxalic ether
Diethyl oxalate
Diethyl ethaneioate
Molecular
Formula: C6H10O4
O - CH2CH3
I
c = o
Structure: I
C = O
I
O - CH2CH3
Chemical Properties
Molecular Weight: 146.14 Physical State: Liquid
Vapor Pressure: 1 mm at 47.4°C Vapor Density: 5.04
Boiling Point: 185.7°Cat 760mm Melting Point: -38.5°C
Density: 1.0785 at 20°C/4°C Solubility: Slightly (hot H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
Disaster hazard—moderate-toxic fumes
All-322
-------
Ethyl oxalate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 400mg/kg rat oral
Non-lethal Acute Effects:
Local irritant
Ingestion causes severe damage to kidneys
Caustic effect on mouth, esophogus, and stomach
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: tLV:
Other Chronic Effects:
AII-323
-------
Ethyl parathion
CHEMICAL NAME
CAS Number: 25737-28-4
Chemical Name: Phosphorothioic acid, O,O-diethyl-O-(p-nitrophenol) ester
Synonyms:
Ethyl parathion
6,O-Diethyl O-p-nitrophenyl thiophosphate
Alkron
Compound 3422
Penphos
Vapophor
C,0H14N03PS
NO.
Molecular
Formula:
Structure:
O - P - (OC2H5)2
Chemical Properties
Molecular Weight: 291.3
Vapor Pressure:
Boiling Point:
Density: 1.26 at 25°C/4°C
Octanol/Water Parti-
tion Coefficient: 2.15
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: 375°C
Solubility: Slightly soluble (H2O)
AII-324
-------
Ethyl parathion
PRODUCTION DATA
Annual U.S.
Production: 15 x 106 Ibs.
Fraction of
Dispersion: 1 -0
Release Rate (million Ibs/yr): 15.2
Consumption: 15.0 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.01
Acute Toxicity
LD50
LD
Lo
Chronic Toxicity
TOXICITY DATA
Dosage Animal
2 mg/kg rat
7 mg/kg rat
1500 mg/kg rat
6 mg/kg mouse
40 mg/kg rabbit
600 mg/kg guinea pig
3 mg/kg pigeon
6 mg/kg quail
2340 mg/kg duck
6 mg/kg mammal
2 mg/kg wild bird
10 mg/m3 (2 hours) rat
50 mg/m3 (2 hours) rabbit
14 mg/m (2 hours) guinea pig
240 mg/kg human
3 mg/kg rat
30 mg/kg mouse
Route
oral
skin
intraperitoneal
oral
skin
skin
oral
oral
oral
unreported
roal
inhalation
inhalation
inhalation
oral
intravenous
subcutaneous
U.S. Occupational Standard: (air) TWA 110 Mg/m3 (skin)
Farm worker field reentry standard
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AII-325
-------
Ethyl silicate
CHEMICAL NAME
CAS Number: 78-10-4
Chemical Name: Silicic acid, tetraethyl ester
Synonyms: Ethyl silicate
Tetraethyl-o- silicate
Molecular
Formula:
OCH2
I _
Structure: CH3CH2O - Si-OCH2CH3
I
ocH2CH3
Chemical Properties
Molecular Weight: 208.30
Vapor Pressure: 1 mm at 20°C
Boiling Point: 168.8 C at 760 mm
Density: °-933 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard: Fire-moderate
Physical State: Liquid
Vapor Density:
Melting Point: -82.5°C
Solubility: Soluble, decomposes (HjO)
AII-326
-------
Ethyl silicate
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
Dosage
1000mg/kg
1000 ppm (4 hours)
1060 ppm (4 hours)
700 ppm (6 hours)
Non-lethal Acute Effects:
Irritant to eyes and upper respiratory tract
Nephritis
Liver injury
Anemia
Leucocytosis
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: .
Other Chronic Effects:
Animal
rat
rat
rat
guinea pig
Route
oral
inhalation
inhalation
inhalation
TLV: 100 ppm
'AII-327
-------
TECHNICAL REPORT DATA
(Please read Instructions on the reverse before completing)
1. REPORT NO.
EPA-450/3-77-008C
2.
3. RECIPIENT'S ACCESSION NO.
4. TITLEjAND SU
mfn'ary Scoring of Organic Air Pollutants:
Chemistry, Production and Toxicity of Selected
Synthetic Organic Chemicals
n-F) Appendix II
5. REPORT DATE
October 1976
6. PERFORMING ORGANIZATION. CODE
7. AUTrtOR(S
8. PERFORMING ORGANIZATION REPORT NO.
J. Dorigan, B. Fuller, R. Duffy
9. PERFORMING ORGANIZATION NAME AND ADDRESS
The Mitre Corporation
Metrek Division
Westgate Research Park
McLean, Virginia 22101
10. PROGRAM ELEMENT NO.
11. CONTRACT/GRANT NO.
68-02-1495
12. SPONSORING AGENCY NAME AND ADDRESS
13. TYPE OF REPORT AND PERIOD COVERED
EPA, Office of Air Quality Planning and Standards
Strategies and Air Standards Division
Research Triangle Park, N.C. 27711
14. SPONSORING AGENCY CODE
15. SUPPLEMENTARY NOTES
16. ABSTRACT
This is the second of a series of four appendices to the report "Scoring
of Organic Air Pollutants." The entire appendix contains a compilation of
available data on chemical structure and properties, environmental persistence,
production, and toxicity for 637 synthetic organic chemicals.
17.
KEY WORDS AND DOCUMENT ANALYSIS
DESCRIPTORS
b.lDENTIFIERS/OPEN ENDED TERMS C. COSATI Field/Group
organic chemical structure
organic chemical properties
organic chemical production
organic chemical toxicity
18. DISTRIBUTION STATEMENT
19. SECURITY CLASS (ThisReport)
unclassified
21. NO. OF PAGES
344
unlimited
20. SECURITY CLASS (Thispage)
unclassified
22. PRICE
EPA Form 2220-1 (9-73)
-------