EPA-450/3-77-008c
October 1976
       PRELIMINARY SCORING
       OF SELECTED ORGANIC
              AIR POLLUTANTS
                 APPENDIX II -
   CHEMISTRY, PRODUCTION,
                 AND TOXICITY
                 OF CHEMICALS
                 D THROUGH
  U.S. ENVIRONMENTAL PROTECTION AGENCY
      Office of Air and Waste Management
   Office of Air Quality Planning and Standards
   Research Triangle Park, North Carolina 27711

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                                     EPA-450/3-77-008c
            PRELIMINARY SCORING


OF SELECTED ORGANIC AIR POLLUTANTS


                  APPENDIX II -


          CHEMISTRY, PRODUCTION,


                  AND TOXICITY


                  OF CHEMICALS


                  DTHROUGH E



                           by

                   J. Dorigan, B. Fuller and R. Duffy

                      The Mitre Corporation
                        Metrek Division
                      Westgate Research Park
                      McLean, Virginia 22101


                      Contract No. 68-02-1495


                        Project No. 077L


                  EPA Project Officer: David R. Patrick



                        Prepared for

                ENVIRONMENTAL PROTECTION AGENCY
                  Office of Air and Waste Management
                Office of Air Quality Planning and Standards
                Research Triangle Park, North Carolina 27711

                        October 1976

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                           PREFACE

     A program is being developed by the Emission Standards and
Engineering Division of the U.S. Environmental Protection Agency to
determine the extent and environmental effects of atmospheric industrial
emissions of synthetic organic chemicals.  As part of the initial effort,
EPA requested that the MITRE Corporation, METREK Division, devise a
system for identifying those chemicals that may be released to the
atmosphere from chemical manufacturing plants and whose health effects
have been documented.  To address this need, three general categories of
information for each compound to be evaluated were deemed directly
relevant:
     (1) the quantity of the compound produced;
     (2) the potential for atmospheric release from chemical manu-
         facturing plants, and
     (3) the toxicological effects of the compounds.
The results of this study are presented  in the accompanying report
"Preliminary Scoring of Organic Air Pollutants."
     The following dossiers were prepared for each of the 637 compounds
under consideration in an attempt to collate the pertinent data for
subsequent evaluation.

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                         TABLE OF  CONTENTS
Dacthal                    '                                   AII-2
Dalapon                                                       AII-4
Dasanit                                                       AII-6
DBCP                                                          AII-8
DDT                                                           AII-10
Decahydronaphthalene                                          AII-12
Decyl alcohol                                                 AII-14
Deet                                                          AII-16
DEF                                                           AII-18
Diacetone  alcohol                                             AII-20
Diaminobenzoic acid                                           AII-22
Diazinon                                                      AII-24
Diazomethane                                                  AII-26
Dibromodifluoromethane                                .        AII-28
Di-tert-butyl-p-cresol                                        All-30
Dibutyl phthalate                                             AII-32
2,4-Dichloroaniline                                           AII-34
3,4-Dichloroaniline                                           AII-36
o-Dichlorobenzene                                             A1I-38
p-Dichlorobenzene                                             A1I-40
Dichlorobenzidine                                             AII-42
Dichlorodifluoromethane                                       AII-44
l,3-Dichloro-5,5-dimethylhydantoin                            AII-46
Dichloroethylene                                              AII-48
Dichloroethyl ether                                           AII-50
Dichlorofluoromethane                                         AII-52
Dichlorohydrin                                                AII-54
Dichloropentane                                               AII-56
2,4-Dlchlorophenoxyacetic  acid                                AII-58
Dichloropropane                                               AII-60
Dlchloropropene                                             -  AII-62
Dichlorotetrafluoroethane                                     AII-64
Dicofol                                                .       AII-66
Dicumyl peroxide,                                             AII-68
Dicyclohexylamine                                             All-70
Dieldrin                           .                           AII-72
Diethanolamine                                                All-74
Diethylamine                                                  AII-76
Diethylaminoethanol                                           AII-78
Diethylene glycol                                             AII-80
Diethylene glycol, dibutyl ether                              AII-82
Diethylene glycol, diethyl ether                              All-84
Diethylene glycol, dimethyl  ether                             AII-86
Diethylene glycol, monobutyl ether                            AII-88
                                 m

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                   TABLE OF CONTENTS (CONTINUED)
Diethylene glycol, monobutyl ether acetate                    AII-90
Diethylene glycol, monoethyl ether                            AII-92
Diethylene glycol, monoethyl ether acetate                    AII-94
Diethylene glycol, monohexyl ether                            AII-96
Diethylene glycol, monomethyl ether                           AII-98
Diethylene glycol, monomethyl ether acetate                   AII-100
Diethylenetriamine                                            AII-102
Di(2-ethylhexyl)adipate                                       AII-104
Di(2-ethylhexyl)phthalate                                     AII-106
Diethylstilbestrol                                            AII-108
Diethyl sulfate                                               AII-110
Difluoroethane                                                AII-112
Difolatan                                                     AII-114
Dihydrotrimethylquinoline                                     AII-116
Diisobutylene                                          .       AII-118
Diisobutyl ketone                                             AII-120
Hiisodecyl phthalate                                          AII-122
Diisooctyl phthlate                                           AII-124
Diisopropylamine                                              AII-126
Diketene                                                      AII-128
Dimethoate                                                    AII-130
Dimethoxybenzidine                                            All-132
N,N-Dimethylacetamide                                         AI1-134
Dimethylamine                                                 AII-136
Dimethylaminoazobenzene                                       AII-138
Dimethylaniline                                               AII-140
Dime thyIbutyl acetate                                         All-142
Dimethyl ether  .                                              AII-144
.n,n-Dimethylformamide                                         AII-146
asym-DimethyIhydrazine                                        AII-148
sym-Dimethylhydrazine                                         AII-150
N-(1,4-Dimethylpentyl)-N'-phenyl-p-phenylenediamine           AII-152
Dimethylphthalate                                             AII-154
Dimethyl sulfate                                              AII-156
Dimethyl sulfide                                              AII-158
Dimethyl sulfoxide                                            AII-160
Dimethyl terephthalate                                        AII-162
Dinitrobenzenes (m, o, p)                                     AII-164
Dinitrobenzoic acid                                           AII-166
Dinitro-o-cresol                                              AII-168
2,4-Dinitrophenol                                             AII-170
Dinitrotoluene                                                AII-172
Dinoseb                                                       AII-174
Dioxane                                                       AII-176
                                  IV

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                   TABLE OF CONTENTS (CONTINUED)
Dioxolane                                                     AII-178
Diphenamid                                                    AII-180
Diphenyl                                                      AII-182
Diphenylamine                                                 AII-184
Diphenyl oxide                                                AII-186
Diphenylthiourea                                              AII-188
Dipropylene glycol                                            AII-190
Dipropylene glycol, monomethyl ether                          AII-192
Disodium methanearsonate                                      AII-194
Disulfoton                                                    AII-196
Ditridecylphthalate                                           AII-198
Diuron                                                        AII-200
Dodecane                                                      AII-202
Dodecylbenzene                                                AII-204
Dodecylbenzenesulfonic acid, sodium salt                      All-206
Dodecyl mercaptan                                             AII-208
Dodecylphenol                                                 AII-210
Dodecyl sulfate, sodium salt                                  AII-212
Dodecyl sulfate, triethanolamine salt                         AII-214
Dursban                                                       AII-216
Dyfonate                                                      AII-218
Endosulfan                                                    AII-220
Endothal                                                      AII-222
Epichlorohydrin                                               AII-224
Eptam                                                         AII-226
Ethane                                                        AII-228
Ethanolamine                                                  AII-230
Ethion                                              :          AII-232
Ethyl acetate                                                 AII-234
Ethyl acetoacetate                                            AII-236
Ethyl acrylate                                                AII-238
Ethyl alcohol                                                 AII-240
Ethylamine                                                    All-242
Ethyl sec-amyl ketone                                         AII-244
Ethylbenzene                                                  AII-246
Ethyl bromide                                                 AII-248
Ethyl butyl ketone                                            All-250
Ethyl cellulose        ,                                       AII-252
Ethyl chloride                                                AII-254
Ethyl chloroacetate                                           AII-256
Ethyl cyanoacetate                                            AII-258
Ethylene                                                      AII-260
Ethylene carbonate                                            AII-262
Ethylene chlorohydrin                                         AII-264

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                   TABLE OF CONTENTS (CONCLUDED)
E thylenediamine
Ethylene dibromide
Ethylene dichloride
Ethylene glycol
Ethylene glycol
Ethylene glycol
Ethylene glycol
Ethylene glycol
Ethylene glycol
Ethylene glycol
Ethylene glycol
Ethylene glycol
                 diacetate
                 dibutyl ether
                 diethyl ether
                 dimethyl ether
                 monoacetate
                 monobutyl ether
                 monoethyl ether
                 monoethyl ether acetate
Ethylene glycol, monohexyl ether
Ethylene glycol, monomethyl ether
Ethylene glycol, monomethyl ether acetate
Ethylene glycol, monooctyl ether
Ethylene glycol, monophenyl ether
Ethylene glycol, monopropyl ether
E thyleneimine
Ethylene oxide
Ethyl ether
Ethyl formate
Ethylhexanol
Ethylidene chloride
Ethyl mercaptan
Ethyl methanesulfonate
N-ethylmorpholine
Ethyl naphthalene
Ethyl oxalate
Ethyl parathion
Ethyl silicate
AII-266
All-268
AII-270
AII-272
AII-274
AII-276
AII-278
AII-280
AII-282
AII-284
AII-286
AII-288
All-290
AII-292
AII-294
AH-2 9 6
AII-298
AII-300
AII-302
AII-304
All-306
AII-308
All-310
AII-312
All-314
AII-316
All-318
AII-320
AII-322
AII-324
AII-326
                                 VI

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                  APPENDIX II









CHEMISTRY,  PRODUCTION AND TOXICITY OF SELECTED




         SYNTHETIC ORGANIC CHEMICALS
                     AII-1

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                                   CHEfVHCAL  NAME


CAS Number:      1861-32-1

Chemical Name:    2,3,5,6-Tetrachloro-l ,4-benzenedicarboxylic acid, dimethyl estei

Synonyms:     Dimethyl-2,3,5,6-tetrachloroteiephthalate
               DCAP
               Tetiachloroterephthalic acid, dimethyl estei
Molecular
  Formula:  C10H6Cl4O4
Structure:
Chemical Properties
   Molecular Weight:     332.0                      Physical State:     Solid
   Vapor Pressure:    <0.01 mmat40C              Vapor Density:
   Boiling Point:  (none) decomposes at 360 to 370C   Melting Point:  156C
   Density:    1.70                                  Solubility:  Very slightly soluble (H2O)
                n   .                                          70.5 pp^r7a72~50C)
   Octanol/Water Parti-
     tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
         Stable to ultraviolet irradiation
Safety Hazard:
                                           AII-2

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                                                                              Dacthal


                              PRODUCTION DATA
Annual U.S.
 Production:   2.0 x 106 Ibs.                     Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:   0.01                              duction Lost: 0.015

Release Rate (million Ibs/yr): 2.0
                                TOXICITYDATA

Acute Toxicity              Dosage               Animal               Route
     LD50              3000mg/kg            lat                 oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AII-3

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Dalapon


                                     CHEMICAL  NAME


    CAS Number:     127-20-8

    Chemical Name:   2,2-Dichloropropionic acid, sodium salt

    Synonyms:    Dalapon
    Molecular
      Formula:   C3H3Cl2O2'Na
                       Cl       O
                       I      //
    Structure:    CH3 - C - C
                       I      \
                       a       c
    Chemical Properties

       Molecular Weight:   164.95                     Physical State:    Solid

       Vapor Pressure:                                Vapor Density:

       Boiling Point:    98Cat20mm                 Melting Point:    174 to 176C (decomposes)
       Density:                                      Solubility:    Soluble (H2O) (45 gm/100 ml at 25 C)
                                                                (hydiolyzes above 70C)
       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
                                            AII-4

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                                                                                Dalapon

                               PRODUCTION DATA
Annual U.S.
 Production:    5 x 106 Ibs.                       Consumption:

Fraction of	                   Fraction of Pro-
 Dispersion:    Estimated as 1.0                    duction Lost:   0.015

Release Rate (million Ibs/yr):   5.0
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
       LDSO          7500 to 9300 mg/kg           rat                 oral
                           3860 mg/kg           rat                 oral
       Low toxicity to man
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects;	.
       Irritant to eyes and skin
                                        All-5

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Dasanit
                                      CHEMICAL  NAME


     CAS Number:    115-90-2

     Chemical Name:  Phosophorothioic acid, O,O-diethyl-O-[p-(methylsulfinyl)phenyl] ester

     Synonyms:   Bayer S767
                 Dasanit
Molecular
  Formula:
                 CUH17O4PS2
     Structure:
                 CHi
                   2o  s
                     \ II
                       p
                 CH3CH2O
o
II
S  - CH3
     Chemical Properties

        Molecular Weight:    276.31

        Vapor Pressure:   <10 mm at 25C

        Boiling Point:

        Density:

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
                                                Physical State:    Liquid

                                                Vapor Density:

                                                Melting Point:

                                                Solubility:
     Safety Hazard:
                                             All-6

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                                                                               Dasanit


                              PRODUCTION DATA
Annual U.S.
 Production:  4 x 106 Ibs.                         Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:  Estimated as 1.0                      duction Lost:   0.015

Release Rate (million Ibs/yr):  4.0
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
       LD50              2 to 10 mg/kg          rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       All-7

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DBCP
                                      CHEMICAL  NAME
     CAS Number:   96-12-8

     Chemical Name:    1,2-Dibromo-3-chloropropane

     Synonyms:  Nemagon
    Molecular
      Formula:   C3HsBr2Cl
                      H   H   H
                      I     I     I
     Structure:    H-C-C-C-H
                      I     I     I
                      Br   Br   Cl
     Chemical Properties

        Molecular Weight:   236.35

        Vapor Pressure:  :

        Boiling Point:   195.5C

        Density:    2.05 at 20C

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOO:

        Atmospheric Reactivity:
Physical State:     Liquid

Vapor Density:

Melting Point:  6.7C

Solubility:   Slightly (1000 ppm) (H2O)
     Safety Hazard:
                                             All-8

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                                                                                     DBCP
Annual U.S.
 Production:

Fraction of
 Dispersion:
              10 x 10 Ibs.
              Estimated as 1.0

Release Rate (million Ibs/yr): 10.0
                                PRODUCTION DATA
Consumption:

Fraction of Pro-
 duction Lost:
0.01
                                  TOXICITY DATA
Acute Toxicity
      LDSO
                           Dosage
                      173 to 275 mg/kg
 Animal
rat
     Route
   oral
 Non-lethal Acute Effects:
      Irritant to skin and mucous membranes
      Narcotic at high concentrations
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                               TLV:
                                         AII-9

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DDT


                                       CHEMICAL  NAME


    CAS Number:   50-29-3

    Chemical Name:  l,l,l-Trichloio-2,2-bis(p-chlorophenyl)ethane
    Synonyms:  a-Bis (p-chlorophenyl) (3/3/3-trichloroethane                 Dicophane
                Dichlorodiphenyltrichloroethane
                Chlorophenothane
    Molecular   	
      Formula:  Ci4H9Cls
                            cci3

    Structure:   Cl-f   V'C-/   V Cf
                             i   v   V
                             H
     Chemical Properties

        Molecular Weight:   354.S                         Physical State:  Solid

        Vapor Pressure:  1.9 x 10~7 Torrsat 20C           Vapor Density:

        Boiling Point:    Decomposes                      Melting Point:  108.5C

        Density:                                         Solubility:    Practically insoluble (H2O)

        Octanol/Water Parti-
         tion Coefficient:   4.96

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
     Safety Hazard:
                                               All-10

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                             DDT
PRODUCTION DATA
Annual U.S.
Production: 45 x 106 Ibs.
Fraction of
Dispersion: 1-0
Release Rate (million Ibs/yr):




45

Consumption:
Fraction of Pro-
duction Lost: 0.015






TOXICITY DATA
Acute Toxicity
LDSO










LDLo
t











Chronic Toxicity
Dosage
113mg/kg
2500 mg/kg
1500 mg/kg
135 mg/kg
280 mg/kg
250 mg/kg
300 mg/kg
250 mg/kg
1000 mg/kg
900 mg/kg
35 mg/kg
31 mg/kg
16 mg/kg
3 gm/kg
113 mg/kg
940 mg/kg
30 mg/kg
7 3 mg/kg (26 wks)
75 mg/kg
50 mg/kg
250 mg/kg
40 mg/kg
50 mg/kg
224 mg/kg

U.S. Occupational Standard: (air): TWA l mg/m3
Animal
rat
rat
rat
mouse
mouse
rabbit
rabbit
rabbit
guinea pig
guinea pig
frog
infant
human
woman
rat
rat
rat
mouse
dog
monkey
cat
cat
rabbit
guinea pig

(skin)
Carcinogenicity: Causes tumors "indicative of cancer" in laboratory rats and
Mutagenicity:
Teratogenicity:
Other Chronic Effects:


TLV:

Route
oral
skin
subcutaneous
oral
intraperitoneal
oral
skin
subcutaneous
skin
subcutaneous
subcutaneous
oral
oral
oral
oral
intraperitoneal
intravenous
oral
intravenous
intravenous
oral
intravenous
intravenous
oral


Tmc


AII-11

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Decahydronaphthalene
                                      CHEMICAL NAME
    CAS Number:   91-17-8

    Chemical Name:    Decahydronaphthalene

    Synonyms:  Decalin
                Bicyclo[4,4,0] decane
                Naphthane
    Molecular
      Formula:  C10H18
    Structure:
     Chemical Properties

       Molecular Weight:
138.3
       Vapor Pressure:  cis: 1 mm at 22.5C
                      trans:10mmat47.2C
       Boiling Point:

       Density:   cis:0.89?7 20C/4C
                 trans:0.8700 20C/4C
       Octanol/Water Parti-
         tion Coefficient:
Physical State:  Liquid

Vapor Density:  4.76

Melting Point:   cis:-43.2C
               trans:-31.5C
Solubility:   Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fire-moderate
                                             AII-12

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                                                            Decahydronaphthalene
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSO              4170 rag/kg            rat                 oral
                          500 ppm (2 hours)      rat                 inhalation
 Non-lethal Acute Effects:
      Irritant-skin, eyes, and mucous membranes
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:  Damage to kidney
                                       AII-13

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Decyl alcohol
                                      CHEMICAL  NAME
    CAS Number:   112-30-1

    Chemical Name:   Decyl alcohol

    Synonyms:  n-Decyl alcohol
                1-Decanol
                Nonyl carbenol
    Molecular	
      Formula:   Ci0"HO
    Structure:   CH3 (CH2)g - CH2 OH
     Chemical Properties

       Molecular Weight:  158.3                        Physical State: Liquid

       Vapor Pressure: 1 mm at 69.5C                   Vapor Density: 5.3

       Boiling Point:  232.9C                         Melting Point:  6C

       Density:  0.8297 at 20C/4C                     Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fite-moderate
                                              All-14

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                                                                        Decyl alcohol
                              PRODUCTION DATA
Annual U.S.
 Production:    152.5 x 106 Ibs. (1968)

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                     Consumption:

                     Fraction of Pro-
                       duction Lost: 0.015
Acute Toxicity
     LDso
      LC
        so
                                TOXICITY DATA
  Dosage
4720 mg/kg
4000 mg/m3
 Animal
rat
mouse
  Route
oral
inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
                                       AII-15

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Deet
                                     CHEMICAL  NAME
    CAS Number:   134-62-3

    Chemical Name:    N,N-Diethyl-m-toluamide

    Synonyms:   3-Methyl-N J4-diethyl benzamide
    Molecular
      Formula:   C12H17NO
    Structure:
                         C  - N
                                 CH2CH3
                                 CH2CH3
                   CH3
     Chemical Properties

       Molecular Weight:   191.30

       Vapor Pressure:  <10 mm at 25C

       Boiling Point:    160C at 19 mm

       Density:     0.996 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:     Liquid

Vapor Density:

Melting Point:

Solubility:  Insoluble (H2O)
    Safety Hazard:
                                             AII-16

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                                                                                       Deet
Annual U.S.
 Production:

Fraction of
 Dispersion:
              10 x 10 Ibs.
              Estimated as 1.0

Release Rate (million Ibs/yr):  1.0
                                PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                        duction Lost:
0.015
Acute Toxicity
         TOXICITY DATA

  Dosage               Animal
2000 mg/kg            rat
 200 mg/kg            rat
3180 mg/kg            rabbit
  75 mg/kg            rabbit
                                                                     Route
                                                                   oral
                                                                   oral
                                                                   skin
                                                                   intravenous
Non-lethal Acute Effects:
      Irritant to eyes and mucous membranes
      CNS disturbances
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                                TLV:
                                        AII-17

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DEF
                                      CHEMICAL  NAME
    CAS Number:   7848-8

    Chemical Name:    S,S,S,-f ributyl phosphorotrithioate

    Synonyms:  S,S,S,-Tributyl trithiophosphate
                Butyl phosphorotrithioate

    Molecular
      Formula:   C12H27OPS3
Structure:
                                     =  O
    Chemical Properties

       Molecular Weight:   314.43

       Vapor Pressure:  <10 mm at 25C

       Boiling Point:   150C at 0.3 mm

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
                                                 Physical State:     Liquid

                                                 Vapor Density:

                                                 Melting Point:   25C

                                                 Solubility:   Insoluble (H2O)
     Safety Hazard:
                                             All-18

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                                                                                       DEF
                               PRODUCTION DATA
Annual U.S.
 Production:   5 x 106 Ibs.

Fraction of
 Dispersion:    1-0

Release Rate (million Ibs/yr):    5.0
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                 0.015
Acute Toxicity
      LDSO
                                  TOXICITY DATA
  Dosage
150 mg/kg
168 mg/kg
 Animal
rat
rat
  Route
oral
skin
 Non-lethal Acute Effects:
      Muscle cramps
      Cyanosis
      Pulmonary edema
      Coma
      Convulsion
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
      Cumulative effects
                      TLV:
                                        All-19

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Diacetone alcohol
                                      CHEMICAL  NAME
    CAS Number:   123-42-2

    Chemical Name:   4-Hydroxy-4-methyl-2-pentanone

    Synonyms:   4-Hydroxy-2-keto-4-methylpentane
                Diacetone alcohol

    Molecular
      Formula:   C6H12O2
Structure:   (CH3)2 - C - CH2 - C
                     I
                    OH



Chemical Properties

   Molecular Weight:   116.2

   Vapor Pressure:  1.1 mm at 20C

   Boiling Point:    167.9C

   Density:  0.9306 at 25C/4C

   Octanol/Water Parti-
    tion Coefficient:
                                          O
                                         CH,
                                                     Physical State:  Liquid

                                                     Vapor Density:  4.00

                                                     Melting Point:   -42.8C

                                                     Solubility:   Soluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Fire-dangerous
                                              AII-20

-------
                                                                    Diacetone  alcohol
                               PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
       LD50              4000mg/kg            rat                 oral
                           93 mg/kg            mouse              intiaperitoneal

 Non-lethal Acute Effects:                                         |
       Narcotic in high concentrations
       Anemia
       Lesions in liver and kidney
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 50 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                        AII-21

-------
Diaminobenzoic acid
                                    CHEMICAL  NAME
    CAS Number:   535-87-5

    Chemical Name:    3,5-Diaminobenzoicatid

    Synonyms:
    Molecular
      Formula:  C7H8N2O2
    Structure:
    Chemical Properties

       Molecular Weight:  152.16

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State: Solid

Vapor Density:

Melting Point:  240C

Solubility:   Slightly soluble (H20)
           (Soluble in hot H2O)
                                            All-22

-------
                                                          Diaminobenzoic acid
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal             Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AII-23

-------
Diazinon
                                      CHEMICAL NAME


    CAS Number:   333-41-5

    Chemical Name:    Phosphoiothioic acid, O,O-diethyl-O-(2-isopropyl-6-methyl-4-pyriinidyl)ester

    Synonyms:      O,ODiethyl-O-(2-isopropyl-4-methyl-6-pyrimidinyl)-phosphorothioate
    Molecular
      Formula:   Ci2H21N2O3PS
    Structure:
               CH3
                I
               C
              //   \           	
CH3         N       CH           OC2H5
    \       I        II          /
      CH-C       C-O-P
    /         *   /           II \
                CH3

    Chemical Properties

       Molecular Weight:  304.38
                                N
                             S   OC2H5
       Vapor Pressure:    1.4 x 10~* mm at 20C

       Boiling Point:    84C at .002 mm

       Density:     1.116at20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
                                    Physical State:     Liquid

                                    Vapor Density:

                                    Melting Point:

                                    Solubility: 0.004% at room temperature (H2O)
                                            AII-24

-------
                                                                               Diazinon

                               PRODUCTION DATA
Annual U.S.
 Production:   10 x 106 Ibs.                      Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:    Estimated as 1.0                     duction Lost:     0.015

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
      LDSO                76 mg/kg             rat                 oral
                         455 mg/kg             rat                 skin
                          85 mg/kg             mouse               oral
                           2 mg/kg             wild bird            oral
      LDLo                30 mg/kg             rabbit               oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:  TWA100Mg/m3

   Other Chronic Effects:
                                       All-25

-------
Diazomethane
                                     CHEMICAL  NAME
    CAS Number:   334-88-3

    Chemical Name:    Diazomethane

    Synonyms:   Azimethylene
    Molecular
      Formula:   CH2N2
    Structure:    H2C  =  N  =  N
    Chemical Properties

       Molecular Weight:      42.04

       Vapor Pressure:

       Boiling Point:   -23C

       Density:    1.45

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Explosion-severe with alkali metals
Physical State:     Gas

Vapor Density:

Melting Point:   -145C

Solubility:   Decomposes (H2O)
                                            AII-26

-------
                                                                         Diazomethane
                               PRODUCTION DATA
              No known production
Annual U.S.
 Production:

Fraction of
 Dispersion:
Release Rate (million Ibs/yr):
Consumption:   Laboratory reagent only

Fraction of Pro-
 duction Lost:
                                  TOXICITY DATA
Acute Toxicity
      TCLo
      TDLo
                           Dosage
                         175 ppm (10 minutes)
                         272 mg/m3 (2 weeks)
                         467 mg/kg (22 weeks)
                          54 mg/kg (52 weeks)
Non-lethal Acute Effects:
      Irritant leads to asthmatic symptoms
      Pulmonary edema
      Conjunctivitis
      Dermatitis
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 0.2 ppm
   Teratogenicity:

   Other Chronic Effects:
 Animal
cat
rat
mouse
mouse
  Route
inhalation
inhalation
subcutaneous
subcutaneous
   Carcinogenicity:
        TCLo            272 mg/m3 (26 weeks)   rat
      Neoplastic effects:
        TDLo            467 mg/kg (22 weeks)    mouse
                          54 mg/kg (52 weeks)    mouse
   Mutagenicity:
                                                                  inhalation

                                                                  subcutaneous
                                                                  subcutaneous
                                               TLV:
                                         AII-27

-------
Dibromodifluoromethane
                                    CHEMICAL  NAME
    CAS Number:     75-61-6

    Chemical Name:   Dibromodifluoromethane

    Synonyms:     Difluorodibiomomethane
    Molecular
      Formula:  CBi2F2
    Structure:
   Br
   I

-  C

   I
   F
    Chemical Properties

       Molecular Weight:     209.8

       Vapor Pressure: <10mmat25C

       Boiling Point:  24.5C at 760 mm

       Density:     2.288 at 15C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Disaster hazard-dangerous-toxic fumes
                                Physical State:    Heavy liquid

                                Vapor Density:

                                Melting Point:

                                Solubility:      Soluble (H2O)
                                           AII-28

-------
                                                    Dibromodifluoromethane
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
                       2300 ppm            rat                inhalation
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:   100 ppm

   Other Chronic Effects:
                                     AII-29

-------
Di-tert-butyl-p-cresol
                                      CHEMICAL  NAME
     CAS Number:  128-37-0

     Chemical Name:   2,6-Di-tert-butyl-p-cresol

     Synonyms: DBPC;BHT;
               4-Methyl-2,6-di-tert-butylphenol
     Molecular
      Formula:
Butylated hydroxytoluene
0,0'- Di-tert-butyl-p-cresol
     Structure:
     Chemical Properties

        Molecular Weight: 220.40

        Vapor Pressure:   2.24 mm at 100C
        Boiling Point:   265 C at 760 mm

        Density:     1.048 at 20C/4C

        Octanol/Water Parti-
         tion Coefficient:
 Physical State:  Solid

 Vapor Density: 7.6

 Melting Point:  71c

 Solubility:  Insoluble (H2O)
     Environmental Persistence

        BOD:

        Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
          Fire-slight
          Disaster hazard-moderate-toxic fumes
                                              AII-30

-------
                                                             Di-tert-butyl-p-cresol
                               PRODUCTION  DATA

Annual U.S.    6.2 x 106 Ibs. (1968)
 Production:   36 x 106 Ibs.                      Consumption:
             (1976 capacity)
Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:    0.015

Release Rate (million Ibs/yr):  18.4 (1972)
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
     LD50              3510 mg/kg        .    rat                 oral
                        1040 mg/kg            mouse              oral
     LDLo               250 mg/kg            mouse              intiaperitoneal
                         940 mg/kg            cat                 oral
                        2100 mg/kg            rabbit              oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:
      TDLo                550 mg/kg            pregnant rat      oral
   Other Chronic Effects:
                                       AII-31

-------
Dibutyl  phthalate
                                      CHEMICAL NAME
    CAS Number:  84-74-2

    Chemical Name:   Phthalic acid, dibutyl ester

    Synonyms:    DBF
                  Dibutylphthalate
    Molecular
      Formula:
    Structure:
O
II
  - 0(CH2)3CH3

C -
II
O
     Chemical Properties

        Molecular Weight:     278.33

        Vapor Pressure:    0.01 mm at 20C

        Boiling Point:  340.0C

        Density:    1.0484 at 20C/20C

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:      19% of theoretical after 5 days at 20C
                  Total theoretical oxygen demand = 2.25 (gm/gm)
        Atmospheric Reactivity:    Reacts with oxidizing agents
                             Physical State:    Liquid

                             Vapor Density:   9.58

                             Melting Point:    -35 C

                             Solubility:     Insoluble (H2O)
     Safety Hazard:
            Fire-slight
                                              All-32

-------
                                                                Dibutyl  phthalate
                              PRODUCTION DATA
Annual U.S.    	._.	
 Production:   35.5 x 106lbs. (1974)

Fraction of	
 Dispersion:  Estimated as 1.0

Release Rate (million los/yr):  29.5
                   Consumption:    35.5 x 10 Ibs.

                   Fraction of Pro-	.
                     duction Lost:  0.015
Acute Toxicity
       CNS
      TOXICITY DATA

Dosage              Animal

140 mg/kg             human
Chronic Toxicity

   U.S. Occupational Standard:   TWA 5 mg/m3
   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:
       TDLo
   Other Chronic Effects:
874 mg/kg
f LV:   5 mg/m*
  rat
                     Route

                    oral
intraperitoneal
                                       All-33

-------
2, 4-Dichloroaniline
                                     CHEMICAL NAME
    CAS Number:   554-00-7

    Chemical Name:   .  2,4-Dichloroaniline

    Synonyms:   Dichlotoaniline
    Molecular
      Formula:   C6HSC12N
    Structure:
    Chemical Properties

       Molecular Weight:   162.02

       Vapor Pressure:
       Boiling Point:   245C at 759mm

       Density:  1.567 at 20C

       Octanol/Water Parti-
         tion Coefficient:   2.69

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Disaster hazard-dangerous, toxic fumes
Physical State:     Solid

Vapor Density:  5.6

Melting Point:   63 to 64C

Splubility:  Slightly soluble (HjO)
                                             AII-34

-------
                                                             2,  4-Dichloroaniline
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSO              157mg/kg             cat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AII-35

-------
3, 4-Dichloroaniline
                                     CHEMICAL  NAME
    CAS Number:    95-76-1

    Chemical Name:    3,4-Dichloroaniline

    Synonyms:   Dichloroaniline
                l-Amino-3,4-dichlorobenzene

    Molecular
      Formula:   C6H5C12N
    Structure:
                        Cl
    Chemical Properties

       Molecular Weight:  162.02

       Vapor Pressure:

       Boiling Point:    272C

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:  Solid

Vapor Density:

Melting Point:  72C

Solubility:    Insoluble (H2O)
                                            AII-36

-------
                                                             3, 4-Dichloroaniline
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSO               648 mg/kg             rat                oral
                         740 mg/kg             mouse             oral

 Non-lethal Acute Effects:
      Eye
                                              human             inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      All-37

-------
o-Dichlorobenzene
                                     CHEMICAL NAME
    CAS Number:    95-50-1

    Chemical Name:    o-Dichlorobenzene

    Synonyms:
                Dichlorobenzol
    Molecular
      Formula:
                  Cl
    Structure:
                        Cl
     Chemical Properties

       Molecular Weight:  147.0

       Vapor Pressure:  1.45 at 25C

       Boiling Point:    180.5C at 760 mm
   Density:   1.305 at 20 C/4 C

   Octanol/Water Parti-
    tion Coefficient:   3.38

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
      Activity toward RO2 : t^ =
                                 40 days
                        O3:  tw=lday
                        OH:  tw = 3 days
     Safety Hazard:
          Fire-moderate
Physical State:  Solid

Vapor Density:  5.05

Melting Point:   -17C

Solubility:   Insoluble (H2O)
                                             AII-38

-------
                                                                  o-Dichiorobenzene
                               PRODUCTION DATA
Annual U.S.
 Production:   62.4 x 106 Ibs.

Fraction of
 Dispersion:    0.42

Release Rate (million Ibs/yr): 27.1
                      Consumption:   62.4 x 106 Ibs.

                      Fraction of Pro-
                       duction Lost:  0.015
                                  TOXICITY DATA
Acute Toxicity
      LCLo
  Dosage
 520 mg/kg
 330 mg/kg
2000 mg/kg
 707 ppm (7 hours)
 800 ppm (24 hours)
Animal
mouse
rabbit
guinea pig
rat
guinea pig
  Route
intravenous
intravenous
oral
inhalation
inhalation
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
      Adenomas
      Carcinomas        _
      Injection site sarcomas
      Mammary, liver and' bladder tumors
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
      Respiratory disorders
      Paraplegia and paraparesis
      CNS inhibition
      Kidney hyperplasia
                      TLV:   50 ppm
                                        AII-39

-------
p-Dichlorobenzene
                                    CHEMICAL  NAME
    CAS Number:    10646-7

    Chemical Name:    p-Dichlorobenzene

    Synonyms:   DCB
                Dichlorobenzol

    Molecular
      Formula:   C6H4C12
    Structure:
    Chemical Properties

       Molecular Weight:   147.0                       Physical State:   Solid

       Vapor Pressure:  10 mm at 54.8C                Vapor Density:

       Boiling Point:   173.4C at 760 mm             Melting Point:   53C

       Density:  1.2475 at 20C/4C                   Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:   3.39

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
          Activity toward ROj: tvj = 40 days
                       03: tyi = lday
                       OH: t% = 3 days
    Safety Hazard:
          Fire-moderate
                                           AII-40

-------
                                                                   p-Dichlorobenzene
                                PRODUCTION DATA

Annual U.S.
 Production:   77.3 x 106 Ibs.                      Consumption:   77.3 x 106 Ibs.

Fraction of                                       Fraction of Pro-
 Dispersion:    0.90                               duction Lost:  0.015

Release Rate (million Ibs/yr): 70.7
                                  TOXICITY DATA

Acute Toxicity                Dosage               Animal               Route
      P-Dichloiobenzene
         LDSo             500mg/kg             rat                 oral
                         2500 mg/kg             rat                 intraperitoneal
                         2950 mg/kg             mouse              oral
                         2800 mg/kg             guinea pig           oral
 Non-lethal Acute Effects:
      Unspecified toxic effects
         TDLo              300 mg/kg             human              oral
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 75 ppm
   Carcinogenicity:
      Adenomas
      Carcinomas
      Injection site sarcomas
      Mammary, liver and bladder tumors
   Mutagenicity:

   Teratogenicity:                                 TLV:

   Other Chronic Effects:
      Respiratory disorders
      Paraplegia and paiaparesis
      CNS inhibition
      Kidney hyperplasia
                                         AII-41.

-------
Dichlorobenzidine
                                      CHEMICAL  NAME
    CAS Number:    91-94-1

    Chemical Name:  3,3'-Dichlorobenzidine

    Synonyms:    4,4'-Diamino-3,3'-dichlbrobiphenyl
                 o ,o' -Dichlorobenzidine
                 3,3'-Dichlorobiphenyl-4,4'diamine
    Molecular
      Formula:
                        Cl
                                     Cl
    Structure:    H2N
    Chemical Properties

       Molecular Weight:    253.02

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:   Solid

Vapor Density:

Melting Point:   133C

Solubility:    Insoluble (H2O)
                                             AII-42

-------
                                                                  Dichlorobenzidine
Annual U.S.
 Production:    4.6 x 106 Ibs.

Fraction of
 Dispersion:  

Release Rate (million Ibs/yr):   0.01
                               PRODUCTION DATA
                       Consumption:
                       Fraction of Pro-
                        duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
   Dosage
  4740 mg/kg
Non-lethal Acute Effects:
       Allergen
       Irritant
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
       TDLo
  26 gm/kg (50 weeks)
   8 gm/kg (43 weeks)
5100 mg/kg (44 weeks)
5200 mg/kg (48 weeks)
  16 gm/kg
 180 grams (170 weeks)
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
 rat
 rat
 mouse
 mouse
 dog
 hamster
 Route
oral
oral
subcutaneous
oral
subcutaneous
oral
oral
                       TLV:   SOppm
                                       AII-43

-------
Dichlorodifluoromethane
                                     CHEMICAL  NAME
    CAS Number:    75-71-8

    Chemical Name:     Dichlorodifluoromethane

    Synonyms:   Freon-12
    Molecular
      Formula:   CC12F2
                     F
                     I
    Structure:    Cl - C - a
     Chemical Properties

       Molecular Weight:   120.92                      Physical State:  Gas

       Vapor Pressure:  5085.93 at 25C                 Vapor Density:

       Boiling Point:    -29.8C at 760mm               Melting Point:   -158C
       Density:   1.75 at-115 C                        Solubility:   Soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:
        Atmospheric Reactivity:
           Activity toward OH: unreactive
           Photochemical degradation:  non-photo reactive
           Possibly reactive toward 03

     Safety Hazard:   Disaster-dangerous-toxic fumes of phosgene and fluorides
                                             AII-44

-------
                                                        Dichlorodifluoromethane
                               PRODUCTION DATA

Annual U.S.
 Production:  488.4 x 106 Ibs. (1973)                Consumption:   439.2 x 10* Ibs.

Fraction of                                     Fraction of Pro-
 Dispersion:  0.90                                 duction Lost:  0.015

Release Rate (million Ibs/yr):  401.9
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      MLD               324 mg/1               mouse             inhalation

 Non-lethal Acute Effects:
      Narcotic in high concentrations
Chronic Toxicity

   U.S. Occupational Standard:   (air) 1000 ppm



   Carcinogenicity:


   Mutagenicity:  May be mutagenic in N. crassa

   Teratogenicity:                               TLV:

   Other Chronic Effects:     Increase lymphocyte count
                         Liver damage
                         Transitory hyperemia
                                       AII-45

-------
3-Dichk>ro-5, 5-dimethylhydantoin
                                 CHEMICAL  NAME


 CAS Number:   118-52-5

 Chemical Name:    l,3-Dichloio-5,5-dimethylhydantoin

 Synonyms:  Dactin
            Halane
            DDH
 Molecular
  Formula:
 Structure:
Cl-N
            CHo
                          N - Cl
                              o
                  CH3

 Chemical Properties

    Molecular Weight:   197

    Vapor Pressure:  Sublimes at 100C

    Boiling Point:

    Density:   1.5 at 20C

    Octanol/Water Parti-
     tion Coefficient:

 Environmental Persistence

    BOD:

    Atmospheric Reactivity:
                               Physical State:  Solid

                               Vapor Density:  6.8

                               Melting Point:  130C

                               Solubility:    Slightly (H2O)
 Safety Hazard:  Disaster hazard-dangerous-toxic fumes
                                        AII-46

-------
                                        1, 3-Dichtoro-5, 5-dSmethylhydantoin
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSo              600mg/kg             rat                oral

 Non-lethal Acute Effects:
      Irritant to skin
      CNS depressant
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 0.2 mg/m3



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:  0.2 mg/m3

   Other Chronic Effects:
                                      AII-47

-------
Dichloroethylene
                                       CHEMICAL  NAME
                   cis: 156-59-2
                   trans: 156-60-5
CAS Number:

Chemical Name:  cis: (Z)l,2-Dichloroethylene
                                                  trans: (E) 1,2-Dichloroethylene
    Synonyms:  "cis-, trans-bichloroethylene
                 sym-Dichloroethylene
    Molecular
      Formula:
Structure:
                      _
                     C  = C
               Cl
                           \
                           Cl
                       cis
     Chemical Properties

        Molecular Weight:   96.94
H         Cl
 \	/
  C  =  C
_y       i.
Cl        H

   trans
                                                   Physical State:   Liquid
                                                       Vapor Density:  3.34  (mixed isomers)
   Vapor Pressure:  204.88 mm at 25C
                  (mixed^ isomers)                                       	
   Boiling Point:   60.3C at'TeTrnnrc'cis)"       	Melting Point:   -80.5C (cis7
                  47.5  C (unspecified pressure) (trans)                -50C (trans)
   Density:  r.2"837""at" 20C/4C"(nsT               Solubility:  "SlI^itiy~(H2O) (cislmdlrans)
            1.2565 at 20C/4C (trans)
   Octanol/Water Parti-
     tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:    Reacts with oxidizing materials
       Slow decomposition on exposure  to air and light
     Safety Hazard:   Fire-dangerous
                    Explosion-moderate
                    Disaster hazard-dangerous-chloride
                                                AII-48

-------
                                                                       Dichloroethylene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                       Consumption:

                       Fraction of Pro-
                        duction Lost:
Acute Toxicity
          ~
         TOXICITY DATA

   Dosage               Animal
 770 me/kg             rat
   _
   Central nervous system effects:
      (trans) LDLo
3,300 mg/m-
human
Non-lethal Acute Effects: (unspecified isomer)
   Irritant
   Narcotic
   Dermatitis
   CNS depressant
Chronic Toxicity

   U.S. Occupational Standard:  (air): TWA 200 ppm (cis)



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Route
oral


inhalation
                       TLV:   200 ppm (cis)
                                        All-49

-------
Dichloroethyl ether
                                      CHEMICAL  NAME
     CAS Number:   111-444

     Chemical Name:    Bis(2-chloroethyl) ether

     Synonyms:  Chlorex
                l-Chlpro-2-(g-chlorethoxy) ethane
                /3,0-Dichloroethyl ether
     Molecular   	
      Formula:  C4HgCl2 O
     Structure:    C1-CH2CH2-O-CH2-CH2-C1
     Chemical Properties

        Molecular Weight:   143.0

        Vapor Pressure:  1.23 mm at 25C

        Boiling Point:   178C at 760 mm
        Density:   1.2199 at 20C/4C

        Octanol/Water Parti-
         tion Coefficient:
Physical State:   Liquid

Vapor Density:  4.93

Melting Point:  -24.5C

Solubility:   insoluble (H,6)
     Environmental Persistence

        BOD:

        Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   Fire-moderate
                    Disaster hazard-dangerous-toxic fumes
                                              AII-50

-------
                                                                  Dichloroethyl ether
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
      LD5-o

      LCLo
  Dosage
 105 mg/kg
 300 mg/kg
1000 mg/kg
Animal
rat
guinea pig
rat
 Non-lethal Acute Effects:
      Irritant-eyes and nose, mucous membranes
Chronic Toxicity

   U.S. Occupational Standard:
       Talr) Ceiling level: 15 ppm (skin)
   Carcinogenicity:
       TDLo

   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 192 mg/kg (79 weeks)    mouse
 Route
oral
skin
inhalation
                   oral
                      TLV:  15 ppm
                                        AII-51

-------
Dichlorofluoromethane
                                     CHEMICAL  NAME
    CAS Number:    75-434

    Chemical Name:     Dichlorofluoromethane

    Synonyms:   Freon 21
                Fluotodichloromethane

    Molecular
      Formula:   CHC12F



                    Cl
                     I
    Structure:   H - C - F
                     I
                    Cl



    Chemical Properties

       Molecular Weight:   103

       Vapor Pressure:  1387.5 mm at 25C

       Boiling Point:    8.9C at 760 mm
       Density:   1.405 at 9 C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Physical State:  Gas

Vapor Density:  3.82

Melting Point:  -135C

Solubility:    Insoluble (H2O)
     Safety Hazard:    Disaster hazard-dangerous-chlorides and fluorides
                                            All-52

-------
                                                             Dichlorofluoromethane
                               PRODUCTION DATA

Annual U.S.
 Production: 487 x 106 Ibs. (1973)                 Consumption:    487 x 106 Ibs.

Fraction of                                     Fraction of Pro-
 Dispersion:  i.o                                  duction Lost:  0.01S

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
                         10,000 ppm (1 hr)       guinea pig           inhalation
Non-lethal Acute Effects:
       Narcotic in high concentration
Chronic Toxicity

   U.S. Occupational Standard:  (aii): TWA 1000 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:   1000 ppm

   Other Chronic Effects:
                                        AII-53

-------
Dichlorohydrin
                                      CHEMICAL  NAME
    CAS Number:   96-23-1

    Chemical Name:    l,3-Dichloro-2-propanol

    Synonyms:  o-Propenyldichlorohydrin
                Glycerol dichlorohydrin
                GDCH
    Molecular           	
      Formula:  aSjOLO"
                  362
                ci            ci
                i             i
    Structure:   CH2 - CH  - CH2

                       OH


    Chemical Properties

       Molecular Weight:  128.99

       Vapor Pressure:   1 mm at 28C

       Boiling Point:    174C

       Density:   1.367 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Dichlorohydrin
1,3-Dichloro-2-propanol
Dichloroisopropyl alcohol
          Physical State:  Liquid

          Vapor Density:  4.45

          Melting Point:   -4C

          Solubility:    Slightly (H2O)
     Safety Hazard:   Fire-moderate
                    Disaster hazard-dangerous-toxic fumes-phosgene
                                               AII-54

-------
                                                                        Dichtorohydrin
                               PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity  .             Dosage               Animal              Route
      LD50              490 mg/kg             rat                 oral
                         800 mg/kg             rabbit              skin
                           93 mg/kg             mouse              oral
                         125 ppm (4 hours)      rat                 inhalation
 Non-lethal Acute Effects:
      Irritant-mucous membranes
      Anemia
      Hepatitis
      Nephritis
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                        AII-55

-------
Dichloropentane
                                     CHEMICAL  NAME
    CAS Number:    628-76-2

    Chemical Name:     1,5-Dichloropentane

    Synonyms:
    Molecular
      Formula:   C5H10C12
    Structure:   Cl - CH2 - CH2 - CH2 - CH2 - CH2 - a
    Chemical Properties

       Molecular Weight:  141.04                      Physical State:   Liquid

       Vapor Pressure:  20 mm at 25C                  Vapor Density:  4.86

       Boiling Point:    180C at 760 mm "              Melting Point:   -72.8C
       Density:   1.1006 at 20C/4C                   Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
           Activity toward 03: t^ = 3 days
                        OH: 1% = 3 days
    Safety Hazard:
          Fire -dangerous
          Disaster hazard-toxic fumes-phosgene
                                            AII-56

-------
                                                                  Dichforopentane
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LI>Lo               *>4 mg/kg             mouse             intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       All-57

-------
2, 4-Dichlorophenoxyacetic acid
                                    CHEMICAL  NAME
    CAS Number:   94-75-7

    Chemical Name:   (2,4-Dichlorophenoxy) acetic acid

    Synonyms:  2,4-D
    Molecular
      Formula:  C8H6CljO3
                        a
    Structure:   Cl -/   V  O -
CH2 - COOH
    Chemical Properties

       Molecular Weight:   221

       Vapor Pressure:  0.4 mm at 160C

       Boiling Point:   160C at 0.4 mm

       Density:    1.560 at 30C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:   Solid

Vapor Density:  7.63

Melting Point:   140 to 141C

Solubility:   Slightly soluble
           (
-------
                                            2, 4-Dichlorophenoxyacetic acid
                              PRODUCTION DATA
Annual U.S.
 Production:  43.0 x 106 Ibs.

Fraction of
 Dispersion:  1.0

Release Rate (million Ibs/yr): 43.4
                      Consumption:   43.0 x 10  Ibs.

                      Fraction of Pro-
                       duction Lost:   0.01
                                 TOXICITY DATA
Acute Toxicity
      LD50
  Dosage
  80 mg/kg
 375 mg/kg
1500 mg/kg
 368 mg/kg
 100 mg/kg
1400 mg/kg
 541 mg /kg
 375 mg/kg
 Animal
 human
 rat
 rat
 mouse
 dog
 rabbit
 guinea pig
 mammal
 Route
oral
oral
skin
oral
oral
skin
oral
oral
 Non-lethal Acute Effects:
      Liver and kidney damage
      CNS depressant
Chronic Toxicity

   U.S. Occupational Standard:  (air): TWA 10 mg/m3



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:
      TDLo
   Other Chronic Effects:
  25 mg/kg
TLV:
 pregnant rat
oral
                                       AII-59

-------
Dichloropropane
                                      CHEMICAL  NAME
    CAS Number:   78-8Y-5
    Chemical Name:    1,2- Dichloropropane

    Synonyms:   Propylene dichloride
    Molecular
      Formula:
                 Q    Cl
                  I      I
    Structure:   CH2 - CH - CH3
     Chemical Properties

       Molecular Weight:   113.0                        Physical State:  Liquid

       Vapor Pressure:  53.02 mm at 25C               Vapor Density:  3.9

       Boiling Point:   96.37C at 760 mm              Melting Point:    -100.44C
        Density:   1.1560 at 20C/4C                    Solubility:    Slightly soluble  (20 gm/1 H2O)
       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:    Reacts with oxidizing materials
     Safety Hazard:   r'ire-dangerous
                    Disaster hazard-dangerous-chlorides
                                             AII-60

-------
                                                                       Dichloropropane
                               PRODUCTION DATA
Annual U.S.
 Production: 60 x 106 Ibs.

Fraction of
 Dispersion:  l.o

Release Rate (million Ibs/yr):  60.6
                     Consumption:    60 x 106 Ibs.

                     Fraction of Pro-
                      duction Lost:   0.1
                                  TOXICITY DATA
Acute Toxicity
       LDSO
         L6
 Dosage
1900 mg/kg
 860 mg/kg
5000 mg/kg
2000 ppm (4 hours)
 Non-lethal Acute Effects:
       Dermatitis
       Degeneration of liver, kidney, heart
Chronic Toxicity

   U.S. Occupational Standard: (air): TWA 75 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
mouse
dog
rat
 Route
oral
oral
oral
inhalation
                     TLV:  75 ppm
                                        AII-61

-------
Dichloropropene
                                      CHEMICAL  NAME
    CAS Number:   52-75-6

    Chemical Name:    1,3-Dichloropropene

    Synonyms:  1,3-Dichloropropylene
    Molecular
      Formula:   CH  C\
                 Cl
                               CH2C1
    Structure:         c = C
                    ^       \
                 H             H
                       Cis


    Chemical Properties

       Molecular Weight:   111.0

       Vapor Pressure:  35 mm at 20C

       Boiling Point:   104.3C(cis)
                      112C (trans)
       Density:   1.217 at 20C/4C (cTs)
                 1.224 at 20C/4C (trans)
       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  	
           Activity toward RO2: t'/z = 3 days
           Activity toward OH: t^ = 3 days
                                                 Cl
  C = C
  Trans
             CH2C1
Physical State:   Liquid

Vapor Density:  3.8

Melting Point:

Solubility:  Insoluble (H2O)
           From O3 yields phosgene and chloroacetaldehyde
     Safety Hazard:  Fire-moderate
                   Disaster ha/ard-dangerous-chlorides
                                              AII-62

-------
                                                                    Dichloropropene
                               PRODUCTION DATA
Annual U.S.
 Production:

Fraction of
 Dispersion:
60 x 10 Ibs.
1.0
Consumption:   60 x 106  Ibs.

Fraction of Pro-
 duction Lost:  0.01
Release Rate (million Ibs/yr):  60.6
                                 TOXICITY DATA
Acute Toxicity
       LC
         So
            Dosage
           250 mg/kg
           200 mg/kg
           300 mg/kg
          1000 ppm (4 hours)
 Animal
 rat
 rabbit
 mouse
 man
 Route
oral
skin
oral
inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Suspected carcinogen


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
       Heart, liver and kidney damage
       Highly narcotic
                                TLV:
                                         AII-63

-------
Dichlorotetrafluoroethane
                                     CHEMICAL NAME
    CAS Number:  1320-37-2

    Chemical Name:     Dichlorotetrafluoroethane

    Synonyms:   Fieon 114
                l,l-Dichloro-l,2,2,2-tetrafluoroethane (a)
                l,2-Dichloro-l,l,2,2-tetrafluoroethane (b)
    Molecular
      Formula:   C2 C12 F4
    Structure:
     I     i
Cl - C - C  - F
     I     !
     Cl  F

      (a)
    Chemical Properties  (a).

       Molecular Weight:   171

       Vapor Pressure:  1680.77 mm at 25C

       Boiling Point:    3.6Cat760mm

       Density:    1.455 at 25C/4C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
           Possibly reactive with ozone
           Stable in lower atmosphere
    Safety Hazard:   Disaster hazard-dangerous fluorides and chlorides
    Cl   Q

F - C    C   F

    F    F

     (b)



     Physical State:   Gas

     Vapor Density:

     Melting Point:   -94C

     Solubility:   Insoluble (H2O)
                                             AII-64

-------
                                                    Dichlorotetrafluoroethane
                              PRODUCTION DATA

Annual U.S.
 Production:    21.7 x 106 Ibs. (1973)             Consumption:    21.7xl06lbs.

Fraction of                                    Fraction of Pro-
 Dispersion:                                    auction Lost:  0.015

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Non-lethal Acute Effects:
       Narcotic in high concentrations
Chronic Toxicity

   U.S. Occupational Standard:  (aii) TWA 1000 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AII-65

-------
Dicofol


                                       CHEMICAL  NAME


    CAS Number:     115-32-2

    Chemical Name:   4,4'-Dichloro-a-(trichloromethyl)benzhydrol

    Synonyms:    l,r-Bis(para
-------
                                                                                   Dicofol
Annual U.S.
 Production:
4.0 x 10 Ibs.
Fraction of
 Dispersion:   Estimated as 1.0

Release Rate (million Ibs/yr):   4.0
                                PRODUCTION DATA
                                Consumption:

                                Fraction of Pro-
                                 duction Lost:
              0.015
Acute Toxicity
       LDSO
                                  TOXICITY DATA
            Dosage
            575 mg/kg
            100 mg/kg
           1150 mg/kg
           1810 mg/kg
           1870 mg/kg
Animal
rat
rat
rat
rabbit
rabbit
 Route
oral
skin
intraperitoneal
intraperitoneal
skin
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                TLV:
                                        All-67

-------
Dicumyl  peroxide
                                     CHEMICAL  NAME
    CAS Number:    80-43-3

    Chemical Name:   Bis(a,o!-dimethylbenzyl)peroxide

    Synonyms:    Cumine peroxide
                 Isopiopylbenzene peroxide
                 Dicumyl peroxide
    Molecular
      Formula:
                         CH3           CH3

    Structure:   /   Vc-O-O-C^/   )>
                \=/   I              I   \=/
                         CH3           CH3
     Chemical Properties

       Molecular Weight:   270.40

      . Vapor Pressure:   Negligible

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
           Fire-may ignite organic materials on contact
Physical State:   Solid

Vapor Density:

Melting Point:

Solubility:
                                             AII-68

-------
                                                                Dicumyl  peroxide
                              PRODUCTION DATA

Annual U.S.
 Production:    15 x 106 Ibs.                     Consumption:    15 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:  1 -0                                duction Lost:   0.02

Release Rate (million Ibs/yr):   15.3
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
       LDSo              4100mg/kg           rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AII-69

-------
Dicyclohexylamine
                                     CHEMICAL  NAME
    CAS Number:   101-83-7


    Chemical Name:    Dicyclohexylamine


    Synonyms:
    Molecular
      Formula:
                         H

                 /\   '   /\
    Structure:     /    /  N  \   )
    Chemical Properties


       Molecular Weight:  181.32                       Physical State:  Liquid


       Vapor Pressure:    <10 mm at 25C               Vapor Density: 6.27


       Boiling Point:   256C                          Melting Point:  -0.10C


       Density:  0.9123 at 20C/4C                     Solubility:  Slightly soluble (H2O)


       Octanol/Water Parti-

         tion Coefficient:


    Environmental Persistence


       BOD:


       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:  Fire-moderate
                                            AII-70

-------
                                                                 Dicyclohexylamine
                               PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITYDATA

Acute Toxicity               Dosage               Animal              Route
     LD50               373 mg/kg             rat     ,           oral
                        500 mg/kg          ;   mouse              oral
Non-lethal Acute Effects:
     Irritant-local irritation and nervous system excitation
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
     Neoplastic effects:
        TD,                  2400 mg/kg               mouse              subcutaneous
                              (48 week continuous)
   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                        AII-71

-------
Dieldrin
                                      CHEMICAL NAME
    CAS Number:
                     60-57-1
    Chemical Name:    1,2,3,4,10,10-Hexachloro-6,7-epoxy-l ,4,4a,5,6,7,8,8a-octahydro-l,4,5,8-dimethano-
                      naphthalene
    Synonyms:      Compound 497
    Molecular
      Formula:
    Structure:
                                    a
                               a
    Chemical Properties

       Molecular Weight:     381

       Vapor Pressure:  1.78 x 10~7 mmat20C

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:     4.56

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Disaster hazarddangerous, toxic fumes, chloride
Physical State:

Vapor Density:

Melting Point:

Solubility:
   Solid
   176tol77C

Insoluble (0.186 mg/!H2O
        at 25 to 29 Q
                                             AII-72

-------
                                                                                   Dieldrin
Annual U.S.
 Production:

Fraction of
 Dispersion:
                   106 Ibs.
                                PRODUCTION DATA
Consumption:
              Estimated as 1 .0

Release Rate (million Ibs/yr):
Fraction of Pro-
 duction Lost:  0.015
Acute Toxicity
     LDSO
Non-lethal Acute Effects:
     CNS stimulant
                                  TOXICITY DATA

                            Dosage                Animal
                         46 mg/kg              rat
                         60 mg/kg              rat (female)
                         90 mg/kg              rat (male)
                        10.5 mg/kg              mouse
                        400 mg/kg              rabbit
                         27 mg/kg               pigeon
                         20 mg/kg               chicken
                      Route
                   oral
                   skin
                   skin
                   intravenous
                   skin
                                                                   oral
                                                                   oral
Chronic Toxicity

   U.S. Occupational Standard:
  J^arcinogenicity:
      Neoplastic effects:
        TDLo

   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                         730 mg/kg (52 weeks)
                        1800 mg/kg (2 years)
mouse
rat
oral
oral
                                                TLV:    100gm/m3(skin)
                                         All-73

-------
Diethanolamine
                                     CHEMICAL NAME


    CAS Number: 111-42-2

    Chemical Name:  2,2' Iminodiethanol

    Synonyms:   DBA                                Diethylolamine
                Pi (2-hydroxyethyl)-amine              Diolamine
                Bis-hydroxyethylamine                 Diethanolamine
    Molecular
      Formula:   C4HnNO2
                                 NH
                                /    \
    Structure:    HO - CH2 - CH2      CH2 - CH2 - OH
    Chemical Properties

       Molecular Weight:   105.14                      Physical State:   Liquid

       Vapor Pressure:     5 mm at 138C              Vapor Density:  3.65

       Boiling Point:    269.1C                       Melting Point:   28.0

       Density:   1.0919 at 30C/20C                  Solubility:   Infinite (H2O)

       Octanol/Water Parti-
         tion Coefficient:   -2.02

    Environmental Persistence

       BOD:     88% of total theoretical after 20 days at 20C

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   Fire-slight
                                             AII-74

-------
                                                                     Diethanolamine
                               PRODUCTION DATA

Annual U.S.
 Production:    101.1 x 106 Ibs.                   Consumption:   86.1 x 106 Ibs.
Fraction of
 Dispersion:    0.40

Release Rate (million Ibs/yr):  36.0
                      Fraction of Pro-
                       duction Lost:  0.015
                                 TOXiCITY DATA
Acute Toxicity
      LDso
 Non-lethal Acute Effects:
  Dosage
 710mg/kg
2300 mg/kg
3553 mg/kg
       Irritation of skin and mucous membranes
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
mouse
mouse
                      TLV:
 Route
oral
intraperitoneal
subcutaneous
                                       AII-75

-------
Diethylamine
                                      CHEMICAL NAME
    CAS Number:   109-89-7

    Chemical Name:    Diethylamine

    Synonyms:   Diethamine


    Molecular
      Formula:   C4H, tN
                        NH
Structure:    C2HS
                              CH
                               25
     Chemical Properties

       Molecular Weight:   73.1

       Vapor Pressure:  247.1 at 25C

       Boiling Point:    55.5C

       Density:  0.7108at20C/20C

       Octanol/Water Parti-
         tion Coefficient:   0.82
                                                Physical State:   Liquid

                                                Vapor Density:  2.53

                                                Melting Point:   -49.8C

                                                Solubility:   Very soluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
     Safety Hazard:  Fire-dangerous
                                             All-76

-------
                                                                         Diethylamine
                               PRODUCTION DATA
               8.8xlOlbs.(1970)
Annual U.S.
 Production:

Fraction of
 Dispersion:
Release Rate (million Ibs/yr):
Consumption:

Fraction of Pro-
 duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
      LD50
      LCSo
                         540 mg/kg
                         649 mg/kg
                         820 mg/kg
                        4000 ppm (4 hours)
 Animal
 rat
 mouse
 rabbit
 rat
 Route
oral
oral
skin
inhalation
 Non-lethal Acute Effects:
      Irritant to skin and mucous membranes
      Liver damage
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 25 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:   25 ppm

   Other Chronic Effects:    Extremely dangerous if ingested
                                       AII-77

-------
Diethylaminoethanol
                                    CHEMICAL  NAME
    CAS Number:    100-37-8

    Chemical Name:    2-(Diethylamino) ethanol

    Synonyms:   Diethylethanolamine
                Diethylaminoethanol

    Molecular
      Formula:   C6H1SNO
    Structure:   CH3CH2 - N
                              CH2tH2OH
                              CH2CH3
    Chemical Properties

       Molecular Weight:   117.2

       Vapor Pressure:  21 mm at 20C

       Boiling Point:   163Cat760mm

       Density:   0.8921 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:   0.46
Physical State:  Liquid

Vapor Density:  4.03

Melting Point:   -70C

Solubility:    Infinite (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
    Safety Hazard:   Fire-moderate
                                           AII-78

-------
                                                             Diethylaminoethanol
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
Consumption:

Fraction of Pro-
 duction Lost:
                                 TOXICITY DATA
Acute Toxicity              Dosage
      LDSO              1300mg/kg
                         1220 mg/kg
                         1561 mg/kg
                         1260 mg/kg

 Non-lethal Acute Effects:
      Central nervous system
             TCLO        200 ppm
      Irritant to skin and mucous membranes
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 10 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
 rat
 rat
 mouse
 rabbit
 human
 Route
oral
intiaperitoneal
subcutaneous
skin
inhalation
TLV:   10ppm
                                       All-79

-------
Diethylene  glycol
                                      CHEMICAL  NAME


    CAS Number:   111-46-6

    Chemical Name:    Diethylene glycol

    Synonyms:   Diglycol                              Ethylenediglycol
                Bis (2-hydroxylethyl) ether              3-Oxa-l,5-pentanediol
                2,2'-Oxydiethanol
    Molecular
      Formula:   C4H10O3
    Structure:   HO - CH2 - CH2 - O - CH2 - CH2 - OH
    Chemical Properties

       Molecular Weight:   106.12                      Physical State:   Liquid

       Vapor Pressure:  lmmat91.8C                  Vapor Density:  3.66

       Boiling Point:    245C at 760 mm                 Melting Point:   -10.5C

       Density:   1.1184at20C/20C                   Solubility:   Soluble (H2b)

       Octanol/Water Parti-
         tion Coefficient:   1.98

    Environmental Persistence

       BOD:     67% of theoretical
                 Total theoretical oxygen demand = 1.5(gm/gm)
       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Fire-slight
                                             All-80

-------
                                                                   Diethylene  glycol
                               PRODUCTION DATA
Annual U.S.
 Production:    350 x 10* Ibs.

Fraction of
 Dispersion:  0.28

Release Rate (million Ibs/yr):   93.4
                     Consumption:   315 x 10  Ibs.

                     Fraction of Pro-
                      duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
      LD50
 Non-lethal Acute Effects:
      Pulmonary edema
      Nausea and vomiting
      Coma
 Dosage
1000 mg/kg
9000 mg/kg
3300 mg/kg
2000 mg/kg
Animal
human
dog
cat
rabbit
 Route
oral
oral
oral
intravenous
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
                                       AII-81

-------
Diethylene glycol, dibutyl ether
                                     CHEMICAL NAME
    CAS Number:   112-73-2
    Chemical Name:     Bis-(2-butoxyethyl) ether

    Synonyms:   Bis(a-chloroethyl)ether   	
                DiethyTene glycol dibutyl ether

    Molecular	
      Formula:   C12"26O3
    Structure:   C4H9 - O - CH2 - O - C4H9
    Chemical Properties

       Molecular Weight:   218

       Vapor Pressure: 0.02 mm at 20C

       Boiling Point:   2S6C

       Density:  0.8853 at 20C/20C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

      - BOD:

       Atmospheric Reactivity:
    Safety Hazard:   Fire-slight
Physical State:  Liquid

Vapor Density:

Melting Point:   -60.2c

Solubility:    Slightly (H2O)
                                            All-82

-------
                                           Diethylene glycol, dibutyl ether
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LD50              3900 mg/kg           rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Not tested


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                     AII-83

-------
Diethylene glycol,  diethyl ether
                                    CHEMICAL  NAME
    CAS Number:   112-36-7

    Chemical Name:    Bis(2-ethoxyethyl) ether

    Synonyms:  Diethylene glycol diethyl ether


    Molecular
      Formula:  C8H18O3
    Structure:   C2H5 - 0 - CH2 - O - CH2 - CH2 - O - C2H5
    Chemical Properties

       Molecular Weight:   162.26                      Physical State:  Liquid

       Vapor Pressure:  <10 mm at 25C                Vapor Density: 5.6

       Boiling Point:   189C                         Melting Point:  -44.3C

       Density:     0.9082 at 20C/20C                Solubility:   Very soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-moderate
                                           AII-84

-------
                                            Diethylene  glycol,  diethyl ether
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSO              1850mg/kg           guinea pig          oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Not tested


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AH-85

-------
Diethylene  glycol, dimethyl ether
                                    CHEMICAL NAME
    CAS Number:   111-96-6

    Chemical Name:    l,l'-Oxybis[2-methoxyethane]

    Synonyms: ~ Bis(2-methoxyetnyl)ether
               Dimethylcarbitol
               Diglyme
    Molecular
      Formula:  C6H12O3
    Structure:   CH3 - O - CH2CH2 - 0 - CH2CH2 - O - CH3
    Chemical Properties

       Molecular Weight:                             Physical State:   Liquid

       Vapor Pressure:                               Vapor Density:

       Boiling Point:   162.0C                       Melting Point:   -68.0C

       Density:  0.9451 at 20C/20C                  Solubility:   Soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                           AII-86

-------
                                        Diethylene glycol, dimethyl ether
                            PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage             Animal             Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:    Not tested


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                    AII-87

-------
Diethylene glycol,  monobutyl  ether
                                    CHEMICAL  NAME


    CAS Number:   18912-80-6

    Chemical Name:    2-(2-Isobutoxyethoxy) ethanol

    Synonyms:   Butyl carbitol                        Diethylene glycol n-butyl ether
                Butoxy diglycol                       Diglycol monobutyl ether
                Obutyldiethyleneglycol                Diethylene glycol monobutyl ether
    Molecular
      Formula:   CgH18O3
    Structure:   HO - CH2 - CH2 - O - CH2CH2 - O - CH2 - CH2 - CH2 - CH3
    Chemical Properties

       Molecular Weight:   162.2                       Physical State:   Liquid

       Vapor Pressure:  0.01 mm at 20C                Vapor Density:  5-58

       Boiling Point:   230.6C                       Melting Point:   -68.1C

       Density:   0.9536at20C/20C                  Solubility:   Soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
    Safety Hazard:   Fire-moderate
                                           AII-88

-------
                                       Diethylene glycol, monobutyl  ether
                             PRODUCTION DATA
Annual U.S.
 Production:    41.2xl06lbs.

Fraction of
 Dispersion:    0.90

Release Rate (million Ibs/yr):  68.6
                    Consumption:   40.2 x 106 Ibs.

                    Fraction of Pro-
                     duction Lost:   0.015
                                TOXICITY DATA
Acute Toxicity
      LD50
 Dosage
 850 mg/kg
2000 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogeriicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
mouse
guinea pig
 Route
intraperitoneal
oral
                    TLV:
                                     AII-89

-------
Diethylene  glycol, monobutyl ether acetate
                                    CHEMICAL  NAME
    CAS Number:   112-17-4

    Chemical Name:    Acetic acid, decyl ester

    Synonyms:  Butyl "caibitol" acetate
               Diethylene glycol monobutyl ether acetate

    Molecular
     Formula:  C10H2()O4
                                                        O

Structure:   CH3(CH2)3 - O - (CH2)2 - O - (CH2>2  T O - C


                                                        ~'3
                                                          \
                                                            CH,
    Chemical Properties

       Molecular Weight:   204.26                     Physical State:   Liquid

       Vapor Pressure:  <0.01 mm at 20C              Vapor Density:

       Boiling Point:   246.7C at 760 mm              Melting Point:   -32.2C

       Density:   0.981 at 20C/20C                   Solubility:   Soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-moderate
                                           AII-90

-------
                           Diethylene glycol,  monobutyl ether acetate
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXIC ITY DATA

Acute Toxicity              Dosage              Animal             Route
      LD50              2600 mg/kg            rabbit             oral
                        2340 mg/kg            guinea pig          oral
                        5000 mg/kg            chicken            oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogen icity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                    AII-91

-------
Diethylene glycol, monethyl  ether
                                     CHEMICAL  NAME
    CAS Number:    111-90-0

    Chemical Name:     2-(2-Ethoxyethoxy)ethanol
    Synonyms:   Diethylene glycol monoethylethet        Diglycolmonoethyl ether
                Carbitol_	Ethylene diglycol monoethyl ether
                Diethylene glycol, ethyl ether            Cellosolve
    Molecular		 Ethoxydiglycol
      Formula:   C6H14O3
    Structure:     CH3CH2 - O - CH2CH2 - O - CH2CH2OH
    Chemical Properties

       Molecular Weight:     134.17                   Physical State:     Liquid

       Vapor Pressure:  <1.0 mmat 20C                Vapor Density:  4.62

       Boiling Point:    201.9C                        Melting Point:

       Density:  0.9902 at 20C/4C                    Solubility:    Infinite (H2O)

       Octanol/Water Parti-
         tion Coefficient:  -0.93

    Environmental Persistence

       BOD:    87% of theoretical after 20 days at 10C
                Total theoretical oxygen demand =1.9 (gm/gm)
       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-moderate
                                            AII-92

-------
                                          Diethylene  glycol, monethyl  ether
                              PRODUCTION DATA
Annual U.S.
 Production:    24.8 x 106 Ibs.

Fraction of
 Dispersion:    1.0

Release Rate (million Ibs/yr):  36.8
                     Consumption:   24.8 x 106 Ibs.

                     Fraction of Pro-
                      duction Lost:    0.015
                                TOXICITY DATA
Acute Toxicity
      LD50
      LDLo
  Dosage
2900 mg/kg
5638 mg/kg
3900 mg/kg
3000 mg/kg
3620 mg/kg
2000 mg/kg
 900 mg/kg
3070 mg/kg
2000 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
mouse
mouse
dog
rabbit
rabbit
rabbit
guinea pig
rat
  Route
intravenous
subcutaneous
intravenous
intravenous
oral
subcutaneous
subcutaneous
oral
subcutaneous
                     TLV:
                                       AII-93

-------
Diethylene  glycol, monoethyl  ether acetate
                                    CHEMICAL  NAME
    CAS Number:   112-15-2

    Chemical Name:    2-(2-Ethoxyethoxy) ethanol acetate

    Synonyms:  Caibitol acetate
               Diethylene glycol monoethyl ether acetate

    Molecular
      Formula:  C8H16O4
                                                                 O

    Structure:   CH3CH2 - O - CH2CH2 - O - CH2 - CH2  O  C
                                                                \
                                                                 CH3



    Chemical Properties

       Molecular Weight:   176.21                     Physical State:   Liquid

       Vapor Pressure:  0.05mmat20C                Vapor Density:  6-07

       Boiling Point:   217.4C                       Melting Point:   -25C

       Density:   1.0114 at 20C/20C                  Solubility:   Infinite (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Firemoderate
                                          AII-94

-------
                           Diethylene  glycol,  monoethyl ether acetate
                            PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage             Animal             Route
                       3930 mg/kg           guinea pig          oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Not tested


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                    AII-95

-------
Diethylene  glycol, monohexyl  ether
                                    CHEMICAL  NAME
    CAS Number:    112-59-4

    Chemical Name:    2-[2-(Hexyloxy)ethoxy] ethanol

    Synonyms:   Hexyl carbitol
                Diethylene glycol monohexyl ether

    Molecular
      Formula:   C10H22O3
    Structure:   CH3 - (CH2)5 - O - (CH2) - O - CH3 - CH2 - OH
    Chemical Properties

       Molecular Weight:   190.32                      Physical State:   Liquid

       Vapor Pressure:  0.01 mm at 20C                Vapor Density:

       Boiling Point:   258.2C                       Melting Point:   -33C

       Density:   0.9346 at 20C/20C                  Solubility:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       .Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-slight
                                           All-96

-------
                                      Diethylene glycol,  monohexyl ether
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSO              2920 mg/kg           rat                oral
                        1500 mg/kg           rabbit              skin
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Not tested


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                    AII-97

-------
Diethylene glycol, monomethyl ether
                                    CHEMICAL NAME
    CAS Number:   111-77-3

    Chemical Name:    2-(2-Methoxyethoxy) ethanol

    Synonyms:  Methyl caibitol
               Diethylene glycol monomethyl ether

    Molecular
      Formula:  CSH,2O3
    Structure:   CH3 - O - CH2 ~ CH2.- O - CH2 - CH2 - OH
    Chemical Properties

       Molecular Weight:   120.15                     Physical State:   Liquid

       Vapor Pressure:  0.2 ,mm at 20C                Vapor Density:  4.14

       Boiling Point:   194.2C                      Melting Point:

       Density:   1.0354 at 20C/4C                  Solubility:   Infinite (H2O)

       Octanol/Water Parti-
        tion Coefficient:   1.14

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-moderate
                                           AII-98

-------
                                    Diethylene glycol,  monomethyl  ether
                             PRODUCTION DATA

Annual U.S.
 Production:   12.7 x 10* Ibs.                  Consumption:   12.7 x 106 Ibs.

Fraction of                                   Fraction of Pro-
 Dispersion:    1.0                             duction Lost:  0.03

Release Rate (million Ibs/yr):   13.1
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LD50             4160 mg/kg            guinea pig          oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                     AII-99

-------
Diethylene  glycol,  monomethyl  ether acetate
                                   CHEMICAL NAME


    CAS Number:   629-38-9

    Chemical Name:   2-(2-Methoxyethoxy)-ethanol, acetate

    Synonyms:  Methyl carbitol acetate


    Molecular
     Formula:  C?H14O4
                     O
                     II
    Structure:   CH3 - C - O - CH2 - CH2 - O - CH2 - CH2 - O - CH3
    Chemical Properties

       Molecular Weight:   162.19                    Physical State:   Liquid

       Vapor Pressure:  0.12 mm at 20C               Vapor Density:

       Boiling Point:    209.1C                      Melting Point:

       Density:   1-0396 at 20C/20C                 Solubility:   Infinite H2O

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Fire-moderate
                                          AII-100

-------
                        Diethylene glycol, monomethyl ether acetate
                            PRODUCTION DATA

Annual U.S.
 Production:                                Consumption:

Fraction of '                                 Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                              TOXICITY DATA

Acute Toxicity             Dosage              Animal             Route
      LDSO             3460 mg/kg           guinea pig          oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogeniclty: Not tested


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                    AII-101

-------
Diethylenetriamine
                                     CHEMICAL  NAME
    CAS Number:    111-40-4

    Chemical Name:     2,2'-Diethylenetriamine

    Synonyms:   3-Azapentane-l,5-diamine
                Bis [(3-aminoethyl] amine
                DETA
    Molecular
      Formula:   C4Hj-N,
                                   H
                                   I
    Structure:   NH2 - CH2 - CH2 - N - CH2 - CH2 - NH2
    Chemical Properties

       Molecular Weight:   103.17                      Physical State:   Liquid

       Vapor Pressure:  0.22 mm at 20C                Vapor Density:  3.48

       Boiling Point:    207Cat760mm                Melting Point:   -39C

       Density:  0.9586 at 20C/20C                   Solubility:   Infinite (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:    70% of theoretical after 20 days at 20C

       Atmospheric Reactivity:   Reacts with  oxidizing materials
     Safety Hazard:   Fire-moderate
                                            All-102

-------
                                                                 Diethylenetriamine
                               PRODUCTION DATA

Annual U.S.
 Production: 32.4 x 106 Ibs.                       Consumption:   32.4 x 106 Ibs.

Fraction of                                      Fraction of Pro-
 Dispersion:    0.50                              duction Lost:  0.015

Release Rate (million Ibs/yr):   16:7
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LD50               1080mg/kg             rat                  oral
                           74 mg/kg             rat                  intraperitoneal
                           71 mg/kg             mouse               intiaperitoneal
                          1090 mg/kg             rabbit               skin
                          1800 mg/kg             guinea pig            skin

 Non-lethal Acute Effects:
      Irritation of respiratory tract
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:  TWA l ppm

   Other Chronic Effects:     Asthma and skin sensitization
                                       AII-103

-------
Di(2-ethylhexyl)  adipate
                                     CHEMICAL NAME


    CAS Number:   103-23-1

    Chemical Name:   Adipic acid, bis (2-ethylhexyl) ester

    Synonyms:  Bis-(2-ethyl hexyl) adipate                  Dioctyl adipate
               Di-(2-ethylhexyl) adipate
               DOA
    Molecular
      Formula:  22^04
                       O               CH2 - CH3       "
                       II                I
                CH2 - C - O - CH2 - C  - CH2 - CH2 - CH2 - CH3
                I                       H
                CH2
    Structure:    i
                CH2
                I                       H
                CH2 - C - O - CH2 - C  - CH2 - CH2 - CH2 - CH3
                       II             '   I
                       O               CH2 - CH3
    Chemical Properties

       Molecular Weight:  370.58                      Physical State:  Liquid

       Vapor Pressure: <0.01 mm at 20C               Vapor Density: 12.8

       Boiling Point:  214Cat5mm                  Melting Point:  -67.8C

       Density:  0.922 at 25C/4C                     Solubility:  Insoluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
          Reacts with oxidizing materials
          Unreactive towards RC>2 and Os
          Activity toward OH: tw = 2.5 days


    Safety Hazard:  Fire-slight
                                             AII-104

-------
                                                        Di(2-ethylhexyl) adipate
                              PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):  39.4 (1972)
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal               Route
     LD5o               900 mg/kg            rat                intravenous
                         540 mg/kg            rabbit              intravenous
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity: Negative in rats given 6 gm/kg intraperitoneally in 2 months


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       All-105

-------
Di(2-ethylhexyl)  phthalate
                                     CHEMICAL NAME
    CAS Number:   117-81-7

    Chemical Name:   Phthalic acid, bis (2-ethylhexyl) ester

    Synonyms:  Dioctylphthalate
               Di-sec-octylphalate
               OOP
    Molecular  	,	.  ....
      Formula:  C24H38O4
                            Di(2-ethylhexyl) phthalate
    Structure:
    Chemical Properties

       Molecular Weight:  390.6

       Vapor Pressure:    1.3mmat200C

       Boiling Point:   230C at 5 mm

       Density: 0.9861 at 20C/20C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
          Reacts with oxidizing materials
          Unreactive towards ROj and 03
          Activity towards OH:  ti^ = 1 day
     Safety Hazard:
          Fire-slight
                 O/-1T
                 CH2
II                I
C -  O -  CH2 -  CH - CH2 -  CH2 -  CH2 -  CH3


C -  O -  CH2 -  CH - CH2 -  CH2 -  CH2 -  CH3
II                I    
O                CH2

                 CH,
                            Physical State:  Liquid

                            Vapor Density:  16.0

                            Melting Point:  -46C (pour point)

                            Solubility:  Insoluble (H2O)
                                            AII-106

-------
                                                        bi(2-ethylhexyl)  phthalate
Annual U.S.
 Production:  389.7(1974)

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                                PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                        duction Lost: 0.01S
Acute Toxicity
Non-lethal Acute Effects:
      Gastrointestinal
         TDLo
         TOXICITY DATA

  Dosage               Animal
                                                                  Route
143 mg/kg
                                                                oral
      Conjunctivitis
      Irritant to skin and bronchia
Chronic Toxicity
   U.S. Occupational Standard:   (air) TWA 5 mg/m
   Carcinogenicity: Neoplastic effects:
      TDLo                43.2 gm/kg (96 weeks)   rat
   Mutagenicity:
      TDLo
   Teratogenicity:
 15 gm/kg

 30 gin/kg"
                                             pregnant rat
                                             TLV:  5 mg/m3
                                          oral
intraperitoneal
                                                                    intraperitoneal
                                             rat(5-15 days
Other Chronic Effects:                              pregnant)
   Embryotoxicity, reduced fetal size, growth retardation, metabolic disturbances, liver enlargement
   and increased hexobental sleeping time
                                       AII-107

-------
Diethylstilbestrol
                                      CHEMICAL  NAME


    CAS Number:     56-53-1

    Chemical Name:   aX-DiethyM,4'-stilbenediol

    Synonyms:     Stilbesteiol
                  DES
                  4,4'-(l,2-Diethyl-l,2-ethenediyl)-bis-phenol
    Molecular
      Formula:   Ci8H2oO2
    Structure:
                                          CH2CH3
     Chemical Properties

       Molecular Weight:     268.3

       Vapor Pressure:

       Boiling Point:  169 to 172C

       Density:

       Octanol/Water Parti'
         tion Coefficient:     5.07

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Physical State:     Solid

Vapor Density:

Melting Point:

Solubility:  Practically insoluble (H2O)
     Safety Hazard:
          Fire-slight
                                            AII-108

-------
                                                                    Diethylstilbestrol
Annual U.S.
 Production:   .004 x 106 Ibs.

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                                PRODUCTION DATA
                      Consumption:
                       Fraction of Pro-
                        duction Lost:  0.015
                                  TOXICITY DATA
Acute Toxicity
     LD50

     LDLo

Non-lethal Acute Effects:
     Glandular
        TDLo
   Dosage
   34 mg/kg
   67 mg/kg
 2500 mg/kg
 Animal
rat
mouse
mouse
   60 /ig/kg (14 days)    human
   Route
intiapetitoneal
intraperitoneal
oral
                   skin
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
      TDLo
102 gm/kg (2 years)      rat
 18 mg/kg (368 days)    mouse
 40 mg/kg (40 weeks)    mouse
498 mg/kg (44 weeks)    hamster
                   oral
                   oral
                   subcutaneous
                   implant
  	Cancerjn female offspring of women who took diethylstilbesterol during pregnancy
   Mutagenicity: .
   Tenitpgenicityj                                TLV:
      Damage to reproductive tracts of male offspring of women who took diethylstilbesterol during pregnancy
   Other Chronic Effects:
                                        AII-109

-------
Diethyl  suifate
                                      CHEMICAL  NAME
    CAS Number:  64-67-5

    Chemical Name:   Sulfuric acid, diethyl ester

    Synonyms: Ethyl
               Diethyl suifate

    Molecular
      Formula: C4H10O4S
                          CT
                          i
    Structure:   H5C2O -  S++ - OC2H5
                          I
                          o_
     Chemical Properties

       Molecular Weight:  154.18

       Vapor Pressure:    1 mm at 47C

       Boiling Point:  Decomposes to ethyl ether

       Density: 1.1803 at 25C/4C

       Octanol/Water Parti-
         tion Coefficient:
Physical State:  Liquid

Vapor Density: 5.31

Melting Point:  -24.4C

Solubility:  Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-moderate
                                             All-110

-------
                                                                        Diethyl sulfate
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                                               Consumption:

                                               Fraction of Pro-
                                                 duction Lost:
Acute Toxicity
      LDLo
                                  TOXICITY DATA

                            Dosage               Animal
                          350 mg/kg            rat
                          340 mg/kg            rat
                          647 mg/kg            mouse
                          250 ppm (4 hours)      rat
                          750 mg/kg            rat
                                                                     Route
                                                                   subcutaneous
                                                                   intravenous
                                                                   oral
                                                                   inhalation
                                                                   oral
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
      (neoplastic)
   Mutagenicity:
                          1900 mg/kg (81 weeks) (intermittent) rat
                           800 mg/kg (49 weeks) (intermittent) rat
Teratogenicity:
   TDLo
Other Chronic Effects:
                            6 mg/kg

                            85 mg/kg
                                                         mouse
                                                TLV:
                                                 pregnant rat
                                                                   oral
                                                                   subcutaneous

                                                                   intraperitoneal

                                                                   intravenous
                                        AII-111

-------
Difluroethane

                                      CHEMICAL NAME

     CAS Number:   75-37-6
     Chemical Name:   1,1-Difluoroethane
     Synonyms:   Difluoroethane
                 Ethylene fluoride
                 Ethylidene fluoride
     Molecular   	
      Formula:   CHF
                      H
                       I
     Structure:   F  -  C  -  CH,
     Chemical Properties

        Molecular Weight:   66.05                       Physical State:   Gas

        Vapor Pressure:    76mmat21C                Vapor Density:   2.28

        Boiling Point:  -24.7                          Melting Point:   -117C
        Density:   0.95 at 20  (saturated pressure)          Solubility:   Insoluble (HjO)

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:
        Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
          I'ire -dangerous
          Disaster hazard-dangerous-fluorides
                                             All-112

-------
                                                                      Difluoroethane
                               PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route

Non-lethal Acute Effects:
     Irritant to lungs
     Narcotic in high concentrations
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       All-113

-------
Difolatan




                                      CHEMICAL  NAME



    CAS Number:    2425-06-1


    Chemical Name:  Difolatan


    Synonyms:   N-(l ,1,2,2-tetrachloioethylthio)-4-cyclohexone-l ,2-dicarboximide
                 Ortho 5865


    Molecular
      Formula:    C10H9Cl4NO2S
    Structure:
     Chemical Properties


        Molecular Weight:   349.06                      Physical State:   Solid


        Vapor Pressure:                                 Vapor Density:


        Boiling Point:                                   Melting Point:    160C


        Density:                                        Solubility:    Insoluble (H2O)


        Octanol/Water Parti-
         tion Coefficient:


     Environmental Persistence


        BOD:


        Atmospheric Reactivity:
     Safety Hazard:
            Disaster hazard-dangerous chlorides and SOX
                                             AII-114'

-------
                                                                               Difolatan
Annual U.S.
 Production:

Fraction of
 Dispersion:
               2 x 106 Ibs.
                               PRODUCTION DATA
                                              Consumption:
               Estimated as 1.0

Release Rate (million Ibs/yr):   2.0
Fraction of Pro-
 duction Lost:   0.015
                                 TOXICITY DATA
Acute Toxicity
       LD5o
                           Dosage
                          2500 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:
       TDLo
   Other Chronic Effects:
       Reduced weight gain:
          2500 ppm (9 weeks)
                           200 mg/kg
 Animal
 rat
 Route
oral
TLV:
 pregnant hamstei     oral
                                                tat
                                                                   inhalation
                                       AII-115

-------
Dihydrotrimethylquinoline
                                     CHEMICAL NAME


    CAS Number:   147-47-7

    Chemical Name:   l,2-Dihydro-2,2,4-trimethylquinoline

    Synonyms:  Acetone anil                         Acetonanil
               Trimethyldihydroquinoline
               2,2,4-TrimethyH,2,dihydroquinoline
    Molecular
      Formula:  C^H^N


                     ~CH3
    Structure:
  CH3

CH3
    Chemical Properties

       Molecular Weight:  173.3

       Vapor Pressure:   Negligible at 25C
       Boiling Point:   Decomposes

       Density: 1.03at25C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:     Fire-slight
                       Physical State:  Solid

                       Vapor Density:

                       Melting Point:  120C

                       Solubility:  Insoluble (H2O)
                                            AII-116

-------
                                                    Dihydrotrimethylquinoline
                             PRODUCTION DATA
Annual U.S.
 Production:   30.0 x 106 Ibs.

Fraction of
 Dispersion:   1.0

Release Rate (million Ibs/yr):  35.0
                     Consumption:  26.0 x 10 Ibs.

                     Fraction of Pro-
                      duction Lost: 0.30
                                TOXICITY DATA
Acute Toxicity
     LDSO
  Dosage
2000 mg/kg
1450 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
  Route
oral
oral
                     TLV:
                                     AII-117

-------
Diisobutylene
                                      CHEMICAL  NAME
     CAS Number:  12002-23-2

     Chemical Name:   Diisobutylene

     Synonyms:  2,4,4-Trimethyl-l-pentene (a)
               2,4,4-Trimethyl-2-pentene (b)

     Molecular
      Formula:  C8H16
                        CH3
                        I
CH3
I
CH3
I
CHi
    Structure:   CH3 -  C - CH2 - C = CH2
                     CH, - C -CH=  C -
                        CH3
                            CH3
                             (a)
                                  (b)
     Chemical Properties

       Molecular Weight:  112.22

       Vapor Pressure:

       Boiling Point:  (a)  101.44"c
                     (b)  104,9rCat760rnm
                                  6-
        Density:  (a) 0.7150 at 20 C/4 C
                (b) 0.7218at20C/4C
        Octanol/Water Parti-
         tion Coefficient:
                 Physical State:  Liquid [(a) and (b)]

                 Vapor Density: (a) 3.97

                 Melting Point:  (a) -93.48C
                               (b) -106.33C
                 Solubility:  Insoluble [(a) and (b)] (H2O)
     Environmental Persistence

        BOD:

        Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
          Fire-dangerous
                                            AII-118

-------
                                                                         Diisobutylene
                               PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXIC ITY DATA

Acute Toxicity               Dosage              Animal               Route
Chronic Toxicity                                     '

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
      Irritant and narcotic
      Liver and kidney damage
                                       AII-119

-------
Diisobutyl ketone
                                     CHEMICAL NAME
    CAS Number:   108-83-8

    Chemical Name:    2,6-Dimethyl-4-heptanone

    Synonyms:  Isovalerone
               Diisobutyl ketone

    Molecular
      Formula:  C9HigO
                      CH3          O          CH3
                       I             II            I
    Structure:   CH3 - CH - CH2 -  C  - CH2 - CH - CH3
    Chemical Properties

       Molecular Weight:  142.2                       Physical State:  Liquid

       Vapor Pressure:                               Vapor Density: 4.9

       Boiling Point:   168C at 760mm                Melting Point:

       Density: 0.8053 at 20C/4C                   Solubility:  Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:  Fire-moderate
                                           AII-120

-------
                                                                  Diisobutyi ketone
                               PRODUCTION DATA

Annual U.S.
  Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
  Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
                         1416 mg/kg            mouse              oral
                         2000 (ipm (4* hours)      rat                 inhalation
Non-lethal Acute Effects:
      Irritant
      Narcotic in high concentrations
Chronic Toxicity

   U.S. Occupational Standard:  (air):  TWA 25 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      All-121

-------
Diisodecyl phthalate
                                     CHEMICAL  NAME


    CAS Number:   19-16-7

    Chemical Name:    1,2-Benzenedicaiboxylic acid, bis(8-methylnonyl)ester
    Synonyms:   Diisodecyl phthalate
                blDP"
                Plasticizer DDP
    Molecular
      Formula:     C28H88O4
                             Phthalic acid, bis(8-methylnonyl)ester
    Structure:
O           CR,
II           I
C  - (CH2)? CH - CH3

C  - (CH2)? C -  CH3

O           CH,
    Chemical Properties

       Molecular Weight:  446.7

       Vapor Pressure:    <10 mm at 25C

       Boiling Point:   250 to 257C

       Density: 0.966 at 25C/25C

       Octanol/Water Parti-
         tion Coefficient:
                            Physical State:  Liquid

                            Vapor Density: 15.4

                            Melting Point:  -50C
                            Solubility:   Insoluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:  Fire-slight
                                             AII-122

-------
                                                           Diisodecyl phthalate
                             PRODUCTION DATA

Annual U.S.
 Production:   153.3 x 106 Ibs.                   Consumption:  133.3 x 106 Ibs.

Fraction of                                   Fraction of Pro-
 Dispersion:   1.0                               duction Lost: 0.015

Release Rate (million ibs/yr):  135.6
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AII-123

-------
Diisooctyl  phthalate
                                      CHEMICAL  NAME
    CAS Number:   27554-26-3
    Chemical Name:   1,2-Benzenedicarboxylic acid,  diisooctyl ester

    Synonyms:  DIOP
                Diiso^ctylj>hthalate_ _    	
                Phthalic acid, diisooctyl ester
    Molecular
      Formula:  C24H38O4          .

                          6
                          C-O-C8H17
                                  o  it
    Structure:
(CgH. 7 is predominantly isomeric dimethyl hexanols)
                          C-0-C8Hn

                          O
     Chemical Properties

       Molecular Weight:  390.5

       Vapor Pressure:    Negligible at 25C

       Boiling Point:  370C

       Density:  0.986 at 20C/20C

       Octanol/Water Parti-
         tion Coefficient:
       Physical State:  Liquid

       Vapor Density:  13.5

       Melting Point:   -50C

       Solubility:  Insoluble (H2O)
     Environmental Persistence

        BOD:

        Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:  Fire-slight
                                            AII-124

-------
                                                             Diisooctyl  phthalate
                              PRODUCTION DATA

Annual U.S.          """    "                                	
 Production:   43.2 x 106 Ibs. (1973)               Consumption:  43.2 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:    1-0                               duction Lost: 0.015

Release Rate (million Ibs/yr): Estimated at 43.2
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal               Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AII-125

-------
Diisopropylamine
                                    CHEMICAL  NAME
    CAS Number:   108-18-9

    Chemical Name:   Diisopiopylamine

    Synonyms:
    Molecular
      Formula:  C6H1SN
    Structure:
                CH3
                CH3
                             H ,
         _
CH,  - N  - CH-,
                  CH3
                  CHi
    Chemical Properties

       Molecular Weight:  101.19

       Vapor Pressure:
       Boiling Point_  84.1C at 760 mm

       Density:    0.7169 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient: 1.84
                             Physical State:  Liquid

                             Vapor Density: 3.5

                             Melting Point:   -61C

                             Solubility:   Slightly soluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
         Fire-dangerous
                                           AII-126

-------
                                                                  Diisopropylamine
                              PRODUCTION DATA

Annual U.S.
 Production:    2 x 106 Ibs. (1967)                  Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:    0.01                              duction Lost: 0.015

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal               Route
      LDSO               700mg/kg            rat                 oral
      LCLo               1000 ppm (4 hours)      rat                 inhalation

Non-lethal Acute Effects:
      Pulmonary edema
      Irritant to eyes and respiratory tract
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:  5 ppm

   Other Chronic Effects:
                                      AII-127

-------
Diketene
                                      CHEMICAL  NAME
     CAS Number:  674-82-8

     Chemical Name:   4-Methylene-2-oxetanone

     Synonyms:  Acetyl ketene
                3-Buteno-(3-lactone
                Diketene
     Molecular
      Formula:  C4H402
    Structure:   H2C   C   -  O
                      -  i        I
                        CH2 - C  =  O
     Chemical Properties

        Molecular Weight:  84.07

        Vapor Pressure:

        Boiling Point:  127.4C

        Density:  1.0897

        Octanol/Water Parti-
         tion Coefficient:
Physical State:  Liquid

Vapor Density: 2.9

Melting Point:  -7.5C

Solubility:  Decomposes
           Soluble (H2O)
     Environmental Persistence

        BOD;

        Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:  File-moderate
                                            AII-128

-------
                                                                                Diketene

                               PRODUCTION DATA
Annual U.S.    		
 Production:  Dicketene-(none in 1975 in U.S.A.)      Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
     LD5o                560 mg/kg             rat                 oral
                          800 mg/kg             mouse              oral
Non-lethal Acute Effects:
      Irritant to skin and respiratory tract
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                       AII-129

-------
Dimethoate
                                     CHEMICAL NAME


    CAS Number:   60-51-5

    Chemical Name:    Phosphorodithioic acid, S-estei with 2-mercapto-N-methylacetamide O,O-dimethyl ester

    Synonyms:   O.O-dimethyl S-(N-methylcarbamoylmethyl)phosphorodithioate
                Dimethoate

    Molecular
      Formula:   C5H12NO3PS2
    Structure:
CH
                CHq
                                         O
                                          II
                      O
                           - S - CH2 - C - N - CH3
     Chemical Properties

       Molecular Weight:   229.3

       Vapor Pressure:   0.025 mm at 25C

       Boiling Point:   Decomposes

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
             Short-term air contaminant
     Safety Hazard:
                                    Physical State:  Solid

                                    Vapor Density:

                                    Melting Point:  51to52C

                                    Solubility:   Soluble (H2O) (1 to 2% at 27C)
                                            AII-130

-------
                                                                           Dimethoate
Annual U.S.
 Production:

Fraction of
 Dispersion:
              2.0 x 10 Ibs.
                               PRODUCTION DATA
Consumption:
              Estimated as 1.0

Release Rate (million Ibs/yr):  2.0
Fraction of Pro-
 duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
      LDSO
      LD
         100
                           Dosage
                          30 mg/kg
                         147 mg/kg
                         353 mg/kg
                         250 mg/kg
                         350 mg/kg
                          37 mg/kg
                           7 mg/kg
                         250 mg/kg
                         300 mg/kg
                         150 mg/kg
 Non-lethal Acute Effects:
       Nausea
       Lachrymation
       Pulmonary edema
       Convulsion
       Anticholinesterase

Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
human
rat
rat
rat
guinea pig
chicken
wild bird
7aT
cat
mouse
  Route
oral
oral
skin
unknown
oral
oral
oral
oral
oral
oral
                                               TLV:
                                       AII-131

-------
Dimethoxybenzidine
                                     CHEMICAL  NAME
    CAS Number:     119-9CM

    Chemical Name:   3,3'-Dimethoxybenzidine

    Synonyms:    O-Dianisidine
                 Di-para-arninodi-meta-methoxydip'henyl

    Molecular
      Formula:   C   H   NO
     Chemical Properties

       Molecular Weight:   244.29

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:
Physical State:      Solid

Vapor Density:   8.5

Melting Point:   137tol38C

Solubility:    Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
     Safety Hazard:
           Fire-slight
                                            AII-132

-------
                                                            Dimethoxybenzidine
                              PRODUCTION DATA

Annual U.S.	
 Production:    0.367 x 10 Ibs. (1967)              Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:  <0.01                              duction Lost:     0.015

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
       LDSO              1920mg/kg            rat                oral
                         3000 mg/kg            dog                oral
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
       Neoplasms:
         TDLo            13gm/kg(52 weeks)    rat                oral
                         560 gm/kg (70 weeks)    hamster            oral
   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AI1-133

-------
N, N-Dimethylacetamide
                                   CHEMICAL NAME
    CAS Number:  127-19-5

    Chemical Name:   N,N-dime thy lace tamide

    Synonyms:  DMAC


    Molecular
      Formula:  c4H9NO
                      O
    Structure:   CH3 - C -  N
CH,
                               CH,
    Chemical Properties

       Molecular Weight:  87.12

       Vapor Pressure:    1.3 mm at 2SC

       Boiling Point:   T65c7f758 mm
       Density:  0.9366 at 25C/4C

       Octanol/Water Parti-
        tion Coefficient: -0.77

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-slight
                   Physical State: Liquid

                   Vapor Density: 3.01
                   Melting Point:   -20C
                   Solubility:  Infinite (H2O)
                                         AII-134

-------
                                                       N,  N-Dimethylacetamide
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
Acute Toxicity
     LDSO

Non-lethal Acute Effects:
     Systemic effects
        TOXICITY DATA


2240 mg/kg
                          20ppm
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA  10 ppm



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:
      TDLo
   Other Chronic Effects:
  60 mg/kg
 Animal
rabbit
                                             human
TLV:
pregnant rat
    Route
  skin
                                                               inhalation
intraperitoneal
                                     AII-135

-------
Dimethylamine
                                     CHEMICAL  NAME
    CAS Number:   124-40-3

    Chemical Name:    Dimethylamine

    Synonyms:  DMA
    Molecular
      Formula:  C2H7N
    Structure:    H - N
                         CH,
                         CH-,
     Chemical Properties

       Molecular Weight:  45.08

       Vapor Pressure:    1,290 mm at 25C

       Boiling Point:    7.4C

       Density:   0.6804 at 0C/4C

       Octanol/Water Parti-
         tion Coefficient:  -0.38
Physical State: Gas

Vapor Density: 1.55

Melting Point: -93C

Solubility:    Very soluble
     Environmental Persistence

       BOD:   Total theoretical oxygen demand 3.5 gm/gm

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:
          Fire-dangerous
          Explosion-moderate
                                            All-136

-------
                                                                      Dimethylamine
                               PRODUCTION DATA

Annual U.S.
 Production:   95.9 x 106 Ibs.                      Consumption:  95.9 x 106 Ibs.

Fraction of                                      Fraction of Pro-
 Dispersion:    0.20                               duction Lost: 0.015

Release Rate (million Ibs/yr):  20.6
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LDSO                698 mg/kg            rat                 oral
                          316 mg/kg            mouse               oral
                          240 mg/kg            rabbit               oral
                          240 mg/kg            guinea pig            oral
Chronic Toxicity

   U.S. Occupational Standard:  (air) 10 ppm



   Carcinogenicity:


   Mutagenicity:   Increased incidence of ancuploid cells and structural chromosome changes in rats

   Teratogenicity:                                TLV:  lOppm

   Other Chronic Effects:
      Lung inflammation
      Reduced growth rate
                                      AII-137

-------
Dimethylaminoazobenzene
                                    CHEMICAL NAME
    CAS Number:   60-11-7

    Chemical Name:   C.I. Solvent yellow 2

    Synonyms:   N,N-Dimethyl-p-phenylazoaniline
                p-Dimethylaminoazobenzene
    ..    .      Benzeneazodimethylaniline
    Molecular	__.. _
      Formula:   cHN
    Methyl yellow
    Structure:
    Chemical Properties

       Molecular Weight:

       Vapor Pressure:

       Boiling Point:   116C

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
                                           CH
                                           CH,
Physical State:   Solid

Vapor Density:

Melting Point:

Solubility:   Insoluble (H2O)
                                           AII-138

-------
                                                     Dimethylaminoazobenzene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                          Consumption:

                          Fraction of Pro-
                            duction Lost:
Acute Toxicity
             TOXICITY DATA

       Dosage              Animal
      800 mg/kg           "Tat
      500 mg/kg             rat
      300 mg/kg             mouse
      230 mg/kg             mouse
               Route
                                                                  oral
                                                                  intraperitoneal
                                                                  oral
                                                                  intraperitoneal
Chronic Toxicity
   U.S. Occupational Standard:   (carcinogen)
   Carcinogenicity:
   Carcinogenic effects:
      TD"
        Lo
800 mg/kg (40 days)
155 mg/kg (4 weeks, intermittent)
   Neoplastic effects:
      TD,          11 gm/kg (12 weeks, continuous)
                   9600 mg/kg (42 weeks, intermittent)
   Mutagemcity:
rat
rat

mouse
hamster
oral
skin

oral
oral
   Teratogenicity:

   Other Chronic Effects:
                           TLV:
                                       AII-139

-------
Dimethylaniline
                                      CHEMICAL NAME
     CAS Number:   121-69-7

     Chemical Name:   N-N-Dimethylaniline

     Synonyms:  Dimethylaniline
    Molecular
      Formula:  C8HUN
     Structure:
     Chemical Properties

        Molecular Weight:  121.18                       Physical State:  Liquid

        Vapor Pressure:    1 mm at 29.5C               Vapor Density: 4.17

        Boiling Point:   193.1C                         Melting Point:  2.5C

        Density:     0.9557 at 20C/20C                 Solubility:  Slightly (H2O)

        Octanol/Water Parti-
         tion Coefficient:  2.62

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
          Fire-moderate
          Disaster hazard-dangerous-toxic fumes-aniline
                                             AII-140

-------
                                                                     Dimethylaniline
                               PRODUCTION DATA

Annual U.S.
 Production:   15 x 106 Ibs. (1967)                Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:  0.015

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
     LDSO               1770mg/kg            rabbit              skin
     LDko                 50 mg/kg            human             oral
                         1410mg/kg            rat                 oral

Non-lethal Acute Effects:
     Depressant-CNS
     Causes-weakness, tremours, tonic and colonic convulsions, slowness in respiration
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA skin 5 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AII-141

-------
Dimethylbutyl  acetate
                                    CHEMICAL  NAME
    CAS Number:    Not listed in 9th Chemical Index

    Chemical Name:

    Synonyms:   Acetic acid, 1,3-dimethylbutyl estei


    Molecular
      Formula:   C8H16O2
                           /1TJ          OO
                           Crlj    4     *""$
                            i             i
Structure:   CH3 - C  - O - CH - CH2 - CH - CH3
                  II
                  O



Chemical Properties

   Molecular Weight:    144.24

   Vapor Pressure:

   Boiling Point: 130tol37C

   Density:   0.9

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
    Safety Hazard:
           Fiiemoderate
                                                   Physical State:

                                                   Vapor Density:   5.0

                                                   Melting Point:

                                                   Solubility:   Slightly soluble (H2O)
                                          AII-142

-------
                                                         Dimethylbutyl acetate
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
Consumption:

Fraction of Pro-
 duction Lost:
                                TOXICITY DATA
Acute Toxicity              Dosage
       LCLo              4000 ppm

Non-lethal Acute Effects:
       Eye irritation
       TCLo               100 ppm
 Animal
 rat
 human
 Route
inhalation
inhalation
Chronic Toxicity

   U.S. Occupational Standard:   TWA: SO ppm




   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
TLV:
                                     AII-143

-------
Dimethyl  ether
                                     CHEMICAL  NAME
    CAS Number:  115-10-6

    Chemical Name:    Methyl ether

    Synonyms:  Methyl oxide
               Methoxymethane
               Dimethyl ether
    Molecular
      Formula:  C2H6O
    Structure:    CH3 -  O - CH3
     Chemical Properties

       Molecular Weight:  46.07

       Vapor Pressure:    551.3 mm at 25C
       Boiling Point:   -23.7C at 760 mm

       Density: 0^661

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
          Fire-highly dangerous
          Explosion-dangerous
Physical State: Gas

Vapor Density:  1.59
Melting Point:   -138.5C

Solubil ity:   Sol7bTeT74~0~00 mg/1 H2O)~
                                            All-144

-------
                                                                    Dimethyl ether
                              PRODUCTION DATA

Annual U.S.
 Production:                            ,       Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
     Central nervous system depressant
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AII-145

-------
N, N-Dimethylformamide
                                   CHEMICAL  NAME
    CAS Number:    68-12-2

    Chemical Name:    N,N-Dimethylformamide

    Synonyms:   Formic acid, amide
    Molecular
     Formula:   C3H7NO
                               O
    Structure:   CH,  - N - C
                  3    i       "H
                      CHi
    Chemical Properties

       Molecular Weight:  73.11

       Vapor Pressure:  3.7 mm at 25C

       Boiling Point:    152.8C at 760 mm

       Density:  0.9445 at 25C/4C

       Octanol/Water Parti-
        tion Coefficient:
Physical State:   Liquid

Vapor Density:  2.51

Melting Point:  -60.48C

Solubility:   Infinite (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-moderate
                                          AII-146

-------
                                                        N,  N-Dimethylformamide
                               PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LDSO               4200mg/kg             rat                 oral
                         1260mg/kg             rat                 intraperitoneal
                         3500 mg/kg             rat                 subcutaneous
                         2350 mg/kg             rat                 intravenous
                         3750 mg/kg             mouse              oral
                          650 mg/kg             mouse              intraperitoneal
                          470 mg/kg             dog                 intravenous
                          400 mg/kg             cat                 intiaperitoneal
                         1000 mg/kg             rabbit               intrapeiitoneal
                         1800 mg/kg             rabbit               intravenous
                         1030 mg/kg             guinea pig            intravenous

Non-lethal Acute Effects:
      Central nervous system
        irCf^,-             20ppm              rat                 oral
      Conjunctivitis
      Nausea and vomiting
      Anorexia
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 10 ppm (skin)
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV: 10 ppm

   Other Chronic Effects:    Liver damage
                                       AII-147

-------
asym-Dimethylhydrazine
                                    CHEMICAL  NAME
    CAS Number:  57-14-7

    Chemical Name:   1,1-Dimethylhydrazine

    Synonyms:  Demazine
               Asym-dimethylhydrazine
    Molecular
      Formula:
                H             CH3
                   \        /
    Structure:         N - N
                   /        \
                H             CK~
    Chemical Properties

       Molecular Weight:  60.10                       Physical State: Liquid

       Vapor Pressure:   157 mm at 25C               Vapor Density: 1.94
       Boiling Point:   63.3C at 752 mm               Melting Point:  -58C
       Density: 0.78 at 25C/4C                      Solubility:  Very soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:
          Fire-dangerous
          Disaster hazard-highly dangerous-toxic fumes
                                            AII-148

-------
                                                         asym-Dimethylhydrazine
Annual U.S.
 Production:
               1.1 x 106 Ibs.
                               PRODUCTION DATA
Consumption:
Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr):
                                               Fraction of Pro-
                                                duction Lost:    0.0 IS
                                 TOXICITY DATA
Acute Toxicity
      LDSO
      LC50
                           Dosage
                          122 mg/kg
                          102 mg/kg
                          265 mg/kg
                          125 mg/kg
                           60 mg/kg
                         1060 mg/kg
                         1329 mg/kg
                          252 ppm (4 hours)
                          172 ppm (4 hours)
                         3578 ppm (15 minutes)
                          392 ppm (4 hours)
 Animal
rat
rat
rat
mouse
mouse
monkey
rabbit
guinea pig
rat
mouse
dog
  Route
oral
intraperitoneal
oral
oral
intraperitoneal
intraperitoneal
intravenous
skin
inhalation
inhalation
inhalation
 Non-lethal Acute Effects^
     Irritant to eyes
     Cardiovascular collapse
Chronic Toxicity

   U.S. Occupational Standard:   TWA: 1 mg/m3
   Carcinogenicity:
      TDLo
      TDLo
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                         7902 mg/kg (30 weeks)
                          140 mg/kg (8 weeks)
mouse
mouse
oral
intraperitoneal
                                               TLV:   1 mg/m3
                                       AI1-149

-------
sym-Dimethylhydrazine
                                    CHEMICAL  NAME
    CAS Number:   57-14-7

    Chemical Name:   1,2-Dimethylhydrazine

    Synonyms:  1,2-Dimethylhydrazine
               SDMH

    Molecular
      Formula:  C2HgN2
              CH,
CH-,
    Structure:         N - N
                  /         N
                H              H
    Chemical Properties

       Molecular Weight:  60.11

       Vapor Pressure:

       Boiling Point:   81C  at 753 mm

       Density:     0.8274 at 20"C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                   Physical State:

                   Vapor Density:

                   Melting Point:

                   Solubility:   Infinitely soluble (H2O)
                                          AII-150

-------
                                                         sym-Dimethylhydrazine
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                       Consumption:

                       Fraction of Pro-
                        duction Lost:
                                TOXICITY DATA
Acute Toxicity
       LDSO
    Dosage
   100 mg/kg
   220 mg/kg
    95 mg/kg
   280 ppm (4 hours)
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
       TDLo

   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
260 mg/kg (13 weeks)
146 mg/kg (31 weeks)
Animal
rat
rat
hamster
rat
 Route
oral
subcutaneous
intramuscular
inhalation
hamster
hamster
                       TLV:
subcutaneous
intramuscular
                                      AII-151

-------
l-(l,  4-Dimethylpentyl)-N-phenyl-p-phenylenediamine


                                  CHEMICAL NAME


   CAS Number:   3081-014

   Chemical Name:    N-(l ,4-dimethylpentyl)-N' phenyl-p-phenylenediamine

   Synonyms:
   Molecular
    Formula:
                    CH3
                     I
CH3   H          H
 I     I    /=\   I    /=\
   Structure:   CH3 - CH - CH2  - CH2 - CH - N -4    >- N -d    *
   Chemical Properties

      Molecular Weight:  282.24

      Vapor Pressure:    Negligible at 25C

      Boiling Point:

      Density:

      Octanol/Water Parti-
       tion Coefficient:

   Environmental Persistence

      BOD:

      Atmospheric Reactivity:
        Activity toward RO^:  t^ = 4 days
                     03: tvi= 1 day
                     OH: tvi = 1 day


   Safety Hazard:
        Physical State:  Solid

        Vapor Density:

        Melting Point:  40 to 44C

        Solubility:
                                       All-152

-------
                   , 4-Dimethylpentyl)-N-phenyl-p-phenylenediamine
                            PRODUCTION DATA
Annual U.S.
 Production:   20 x 106 Ibs.

Fraction of
 Dispersion:    0.90

Release Rate (million Ibs/yr):    16.8
            Consumption:  18 x 10 Ibs.

            Fraction of Pro-
             duction Lost:   0.03
Acute Toxicity
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
TOXICITY DATA

            Animal
Route
            TLV:
                                   AII-153

-------
Dimethylphthalate
                                     CHEMICAL  NAME
CAS Number:  131-11-3

Chemical Name:   Phthalic acid, dimethyl estei

Synonyms:  o-Dimethyl phthalate
           DMP

Molecular
 Formula:  C10H10O4


                    O
                    II
              _     C - OCH3
            I^V          J
Structure:    I     |l

            ^^ C - OCH3

                       O


Chemical Properties

   Molecular Weight:  194.18

   Vapor Pressure:    0.01 mm at 20C

   Boiling Point:  283.7C at 760 mm

   Density:   1.1905 at 20.7C/4C

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
    Safety Hazard:
                                                   Physical State: Liquid

                                                   Vapor Density: 6.69

                                                   Melting Point:   0 to 2C

                                                   Solubility:   Very slightly (H2O)
                                           All-154

-------
                                                                Dimethylphthaiate
                              PRODUCTION DATA
             10.0xl06lbs. (1974)
Annual U.S.
 Production:

Fraction of
 Dispersion:
Release Rate (million Ibs/yr):
Consumption:

Fraction of Pro-
  duction Lost:
                                                              0.015
                                 TOXICITY DATA
Acute Toxicity
     LCLo
                        1580 ihg/kg
                        4400 mg/kg
                        2400 mg/kg
                        8500 mg/kg
                       10,000 ppm
 Animal
mouse
rabbit
guinea pig
chicken
cat
   Route
intraperitoneal
oral
oral
oral
inhalation
Chronic Toxicity

   U.S. Occupational Standard: (air): TWA 5 mg/m3



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:
     TDLo               852 mg/kg
   Other Chronic Effects:
                                              TLV:
                                              pregnant rat
                   intraperitoneal
                                       All-155

-------
Dimethyl sulfate
                                      CHEMICAL  NAME
    CAS Number:  77-78-1

    Chemical Name:   Sulfuric acid, dimethyl ester

    Synonyms:  Dimethyl sulfate
                Methyl sulfate

    Molecular
      Formula:  C2H6O4S
Structure:    CH3 - O -
                                  - O - CH
                            O(-)
     Chemical Properties

        Molecular Weight:  126.13

        Vapor Pressure:

        Boiling Point:   188C (decomposes)

        Density:     1.3322 at 20C/4C

        Octanol/Water Parti-
         tion Coefficient:
                                                Physical State:  Liquid

                                                Vapor Density: 4.35

                                                Melting Point:  -26.8C

                                                Solubility:  Slight (H2O)
     Environmental Persistence

        BOD:

        Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
          Fire-moderate           '
          Disaster hazard-dangerous-SOx
                                             All-156

-------
                                                                    Dimethyl sulfate
                               PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                      Fraction of Pro-.
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LDSO                440mg/kg            rat                 oral
                          100 mg/kg            rat                 subcutaneous
                          100 mg/kg  .          rat                 intravenous
      LDLo                 32 ppm (4 hours)      rat                 inhalation
                           75 ppm (17 minutes)   mouse  ,            inhalation
                           75 ppm (24 minutes)   guinea pig           inhalation
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:	,-  	
      TDLo:      17 mg/m (18 weeks, intermittent)   rat                 inhalation
     neoplastic effects        	
      TDLo:                200 mg/kg            Tat                 subcutaneous
  . Mutagenicity:
   Teratogenicity:               .                 TLV:  1ppm        	
      TDL0:                 20 mg/kg            pregnant rat         intravenous
   Other Chronic Effects:
                                       AII-157

-------
Dimethyl sulfide
                                     CHEMICAL  NAME
    CAS Number:  75-18-3

    Chemical Name:    Methyl sulfide
    Synonyms:   Dimethyl sulfide
                Methanethiomethane

    Molecular
      Formula:  C2H6S
    Structure:    CH3 - S - CH3
     Chemical Properties

       Molecular Weight:  62.08

       Vapor Pressure:    530.8 mm at 25C
       Boiling Point:   37.3C at 760 mm

       Density:    0.8458 at 21C/4C

       Octanol/Water Parti-
         tion Coefficient:
Physical State: Liquid

Vapor Density: 2.14

Melting Point: -98.27C

Solubility:   Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
          Fire-dangerous
          Explosion-moderate
          Disaster hazard-dangeroustoxic fumesSOX
                                            AII-158

-------
                                                                  Dimethyl sulfide
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ifas/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal               Route
     LD50               535 mg/kg            rat                oral
                        3700 mg/kg            mouse             oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      All-159

-------
Dimethyl  sulfoxide
                                     CHEMICAL NAME
    CAS Number:   67-68-5

    Chemical Name:   Methyl sulfoxide

    Synonyms:  Dimethyl sulfoxide
               DMSO

    Molecular
      Formula:  C2H6OS
                       O
                       II
    Structure:    CH3 - S  - CH3
    Chemical Properties

       Molecular Weight: 78.14                       Physical State:  Liquid (hydroscopic)

       Vapor Pressure:   0.37 mm at 20C              Vapor Density:
       Boiling Point:   189C at 760 mm                Melting Point:  18.45C

       Density:   1.1014 at 20C/4C                   Solubility:  Miscible (H2O)

       Octanol/Water Parti-
         tion Coefficient:  -2.03

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:
          Fire-moderate
          Disaster hazard-moderate-toxic fumes
                                           All-160

-------
                                                                 Dimethyl sulfoxide
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
      LDSO
Non-lethal Acute Effects:
      Allergen
      Irritant to skin
      Corneal opacity
  20 mg/kg
2500 mg/kg
 Animal
rat
dog
  Route
oral
intravenous
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:
      TDLo



   Other Chronic Effects:
   5gm/kg
   8 gm/kg
   5 gm/kg
  50 mg/kg
                      TLV:
pregnant rat
pregnant rat
mouse
hamster
oral
intraperitoneal
intraperitoneal
intravenous
                                      AII-161

-------
Dimethyl terephthalate
                                     CHEMICAL  NAME
     CAS Number:  120-61-6
     Chemical Name:  Terephthalic acid, dimethyl ester
    Synonyms:  Dimethylterephthalate
               DMT

    Molecular
      Formula:  C10H10O4
           1,4-Benzene dicarboxylic acid, dimethyl ester
           Dimethyl 1,4-benzene carboxylate dimethyl ester
                         O
O
II
C - OCH3
    Structure:   CH3O  - C
     Chemical Properties

        Molecular Weight:  194.19

        Vapor Pressure:    1 mm at 100C

        Boiling Point:  (sublimes)

        Density: 1.194at20C/4C

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:
        Atmospheric Reactivity:
          Activity toward OH:   reactive, estimated half life is 3 days
     Safety Hazard:
           Physical State:  Solid

           Vapor Density:
           Melting Point:  141.0 to 141.8C

           Solubility:  Slightly (hot H2O)
                                            AII-162

-------
                                                       Dimethyl terephthalate
                             PRODUCTION DATA

Annual U.S.                   -  -
 Production:    2,714 x 106 Ibs. (1973)            Consumption:  2,714 x 106lbs.

Fraction of                                   Fraction of Pro-
 Dispersion:   0                                duction Lost: 0.015

Release Rate (million Ibs/yr):  32.5
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDSO             4390mg/kg            rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:  Negative in rat                 TLV:

   Other Chronic Effects:
                                     AII-163

-------
Dinitfobenzenes (m,  o,  and p)
                                      CHEMICAL  NAME
    CAS Number:  (m): 99-65-0                (o); 528-29-0
                  (p): 100-25-4     __        _          	
    Chemical Name:  (o):  l,2-Dinitrobenzene~ (p): 1,4-Dinitrobenzene
                    (m): 1,3-Dinitrobenzene
    Synonyms:  Dinitrobenzol
    Molecular
      Formula:  C6H4N2O4
    Structure:
                 ^   i>^
                         N02

                   (m)

    Chemical Properties

       Molecular Weight:  168.11

       Vapor Pressure:
                       (o)



Physical State:  Solid

Vapor Density:  5.79  (unspecified isomer)
        Boiling Point:  (m): 291Cat 756rnnT
                     (p):  299C at J77 mm
                     (o):  319C atY73~mm

        Density:    (m):  1.575""at 18C/4C
                  (p):  1.625 at 18C/4C _
                  (o):  1.3 119atl20C/40C
Melting Point:  (m):~ 90.02C
              (p):  174C
              (o):  118.5C
Solubility:  (m): Slightly (H26)
           (p) and (o): Insoluble (H2O)
        OctanolAVater Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:
       Atmospheric Reactivity:   React with reducing materials

     Safety Hazard:
          Fire-slight
          Explosionsevere
          Disaster hazard-dangerous-toxic fumes-NOx
                                            All-164

-------
                                                 Dinitrobenzenes (m,  o, and  p)
                               PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
m-dinitrobenzene
      LD50               42 mg/kg              wild bird species      oral
      LDjo               27 mg/kg              cat                oral
p-dinitrobenzene
      LDio               29 mg/kg              cat.               oral

Non-lethal Acute Effects:  (unspecified isomer)
      Anemia
      Jaundice
      Kidney damage
      Injury to CNS
Chronic Toxicity

   U.S. Occupational Standardj_(aii):
      m-dinitrobenzene    (air) 1 mg/m            skin
      p-dinitrobenzene     (air) TWA 1 ppm        skin

   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:                               TLV:  1 mg/m3

   Other Chronic Effects:
                                       AII-165

-------
Dinitrobenzoic  acid
                                     CHEMICAL NAME
    CAS Number:    610-30-0

    Chemical Name:     2,-4-Dinitrobenzoic add

    Synonyms:   Dinitrobenzoic acid
    Molecular
      Formula:    C7H4N2O6
    Structure:
                      NO2


    Chemical Properties

       Molecular Weight:   212.12

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:   Solid

Vapor Density:

Melting Point:    183C

Solubility:    Slightly (H2O)
                                            AII-166

-------
                                                            Dinitrobenzoic acid
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal  '           Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AII-167

-------
Dinitro-o-cresol
                                     CHEMICAL  NAME
    CAS Number:    534-52-1

    Chemical Name:  2-Methyl-4,6-dinitrophenol

    Synonyms:    4,6-Dinitro-ortho-ciesol
                 DNOC
                 4,6-Dinitro-2-methyl phenol
    Molecular
      Formula:    C7H6N2O5
    Structure:
 NO?


 \

NO>
                                CH,
                              OH
     Chemical Properties

       Molecular Weight:    198.14
       Vapor Pressure:  1.05 x lO^mm at 25C

       Boiling Point:   312C

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:
                               Physical State:    Solid

                               Vapor Density:   6.82

                               Melting Point:    85.8C

                               Solubility:    Slightly (H2O) (0.013% at 15C)
                                           AII-168

-------
                                                                     Dinitro-o-cresol
                               PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LDSO                25 mg/kg              rat                 oral
                         200mg/kg              rat                 skin
                          47 mg/kg              mouse              skin
                          19 mg/kg              mouse              intraperitoneal
      LCLo                40mg/m3             cat                 inhalation

Non-lethal Acute Effects:
      Central nervous system
        TCLo              1 mg/m3             human              inhalation
      Irritant
      Jaundice
      Circulatory collapse
      Mental disorder
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 200 jug/m3


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:  200^g/m3

   Other Chronic Effects:
                                      AII-169

-------
2, 4-Dinitrophenol
                                     CHEMICAL NAME
    CAS Number:   25550-58-7

    Chemical Name:    Dinitrophenol

    Synonyms:  l-Hydroxy-2,4-dinitiobenzene
    Molecular
      Formula:  C6H4N2O5
    Structure:
                        NO2
     Chemical Properties

       Molecular Weight:  184.11

       Vapor Pressure:

       Boiling Point:   Sublimes

       Density:  1.683 at 24C

       Octanol/Water Parti-
         tion Coefficient:  2.38

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:  Explosion-moderate
Physical State:    Solid

Vapor Density:    6.35

Melting Point:  H2C

Solubility:  5600 mg/1 (H2O)
                                           AII-170

-------
                                                                  2,  4-Dinitrophenol
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                   Consumption:

                   Fraction of Pro-
                     duction Lost:
                                  TOXICITY DATA
Acute Toxicity
     LDSO
30 mg/kg
20 mg/kg
25 mg/kg
45 mg/kg
30 mg/kg
81 mg/kg
13 mg/kg
Non-lethal Acute Effects:
      Liver damage and kidney damage
      Metabolic stimulation
      Dermatitis
 Animal
rat
rat
rat
mouse
rabbit
guinea pig
wild bird
  Route
oral
intraperitoneal
subcutaneous
subcutaneous
oral
oral
oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagen icily:

   Teratogenicity:

   Other Chronic Effects:    Cataracts
                   TLV:
                                       AII-171

-------
Dinitrotoluene
                                     CHEMICAL  NAME
    CAS Number:  121-14-2

    Chemical Name:   2,4-Dinitrotoluene

    Synonyms:   Dinitrotoluol
                DNT

    Molecular
      Formula:   C7H6N2O4
    Structure:
     Chemical Properties

       Molecular Weight:  182.13                       Physical State:    Solid

       Vapor Pressure:                                Vapor Density:    6.27
       Boiling Point:   300C (slight decomposition)       Melting Point:     70.5C

       Density:  1.521 at 15C/4C                     Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
          Fire-moderate
          Explosion-moderate
                                             AII-172

-------
                                                                       Dinitrotoluene
Annual U.S.
  Production:

Fraction of
  Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
   Dosage
1625 mg/kg
 268 mg/kg
  50 mg/kg
 Animal
mouse
rat
mammal
(species unspecified)
   Route
oral
oral
subcutaneous
Non-lethal Acute Effects:
     Anemia
     Liver damage
     CNS depression
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutageniciry:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:    1.5 mg/kg
                                       AII-173

-------
Dinoseb
                                      CHEMICAL  NAME
    CAS Number:     88-85-7

    Chemical Name:     2-(l-Methylpropyl)-4,6-dinitrophenol
    Synonyms:
    Molecular
      Formula:
2,4-Dinitro-6-sec-butylphenol
DNBP
Butaphene
    Structure:
                          N02

     Chemical Properties

        Molecular Weight:    240.2
       Vapor Pressure:   1 mm at 151.1 C

       Boiling Point:   not determined
        Density:   1.2647 at 45 C

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
                                    Physical State:   Liquid

                                    Vapor Density:

                                    Melting Point:   32C

                                    Solubility:    Slightly (H2O)
                                                (0.0052 gm/gm at 25 C)
     Safety Hazard:
            Firepossible risk
                                            AII-174

-------
                                                                                   Dinoseb
Annual U.S.
 Production:
3.0 x 106 Ibs.
                                PRODUCTION DATA
Consumption:
Fraction of
  Dispersion:   Estimated as 1.0

Release Rate (million Ibs/yr):   3.0
                                Fraction of Pro-
                                 duction Lost:   0.015
Acute Toxicity
       LDSO
                                  TOXICITY DATA
            Dosage
           25 mg/kg
           80 mg/kg
           20 mg/kg
            8 mg/kg
           20 mg/kg
           40 mg/kg
           60 mg/kg
            7 mg/kg
 Animal
 rat
 rat
 mouse
 mouse
 guinea pig
 chicken
 mammal
 wild bird
                                                                      Route
                                                                     oral
                                                                     skin
                                                                     oral
                                                                     intiaperitoneal
                                                                     oral
                                                                     oral
                                                                     unknown
                                                                     oral
Non-lethal Acute^Effects:_
      Irritant of eyes and lungs
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
       Metabolic stimulant
           53 mg/kg
                                                TLV:
                                                  pregnant rat
                     intraperitoneal
       Growth depressant, 0.02% of diet (6 months) rats
                                       AII-175

-------
Dioxane
                                      CHEMICAL NAME
     CAS Number:   123-91-1

     Chemical Name:   p-Dioxane

     Synonyms:  1,4-Dioxane
                Para-dioxane
                Diethylene ether
     Molecular
      Formula:  C4H8O3
                                                Diethylene oxide
                                                Dioxyethylene ether
                                                1,4 Diethylene dioxide
    Structure:
Chemical Properties

   Molecular Weight:  88.1

   Vapor Pressure:    39.7 mm at 25C

   Boiling Point:   101.3C at 750mm

   Density:    1.0337 at 20C/4C

   Octanol/Water Parti-
    tion Coefficient:  -0.42

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
     Unreactive toward RC>2 and 63
     Activity toward OH:  Very reactive
                                                     Physical State:  Liquid

                                                     Vapor Density: 3.03

                                                     Melting Point:  H.8C

                                                     Solubility:  Infinite (H2O)
                                           = 9.6 hours
     Safety Hazard:
          Fire-dangerous
          Explosion-moderate
                                             AII-176

-------
                                                                                  Dioxane
                                PRODUCTION DATA
Annual U.S.
 Production:   13.8 x 106 Ibs.

Fraction of
 Dispersion:    1.0

Release Rate (million Ibs/yr): 14.0
                      Consumption:  13.8 x 106 Ibs.

                      Fraction of Pro-
                        duction Lost:    0.015
Acute Toxicity
      LDSO
      LCLo
                                  TOXICITY DATA
  Dosage
 790 mg/kg
2000 mg/kg
2000 mg/kg
3150 mg/kg
 470 ppm
 Animal
mouse
cat
rabbit
guinea pig
                                                human
  Route
intiaperitoneal
oral
oral
oral
                                          inhalation
Chronic Toxicity

   U.S. Occupational Standard: (air): TWA  100 ppm skin
   Carcinogenicity:    TDj,,,:  416 gm/kg/57 weeks continuous hepatocarcinomas,
                           kidney carcinomas, carcinomas
   Mutagenicity:

   Teratogenicity:
                      TLV:  100 ppm
   Other Chronic Effects:
      Inhalation causes irritability followed by narcosis, edema and death
      Liver and kidney damage
      Edema of the brain and lungs
                                        AII-177

-------
Dioxolane
                                     CHEMICAL NAME
    CAS Number:  646-06-0

    Chemical Name: 1,3-Dioxolane

    Synonyms:   Dioxolane
                Glycol methylene ether

    Molecular
      Formula:   C3H6O2
                     -O

    Structure:   6
     Chemical Properties

       Molecular Weight:  74.08                        Physical State:  Liquid

       Vapor Pressure:    70 mm at 20C                Vapor Density: 2.6

       Boiling Point:   75C at 765 mm                 Melting Point:   -95C
       Density:    1.0600 at 20C/4C                  Solubility:  Infinite (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
          Fire-dangerous
                                             AII-178

-------
                                                                              Dioxolane

                               PRODUCTION DATA
Annual U.S.
 Production:                                    Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LDSO               3000mg/kg             rat                 oral
                          729 mg/kg             mouse              intraperitoneal

Non-lethal Acute Effects:
      TDL0                  7 mg/kg             human              oral
      Psychotropic effect
      Inhalation and ingestion can have moderate effects
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                       AII-179

-------
Diphenamid
                                      CHEMICAL  NAME


     CAS Number:     957-51-7

     Chemical Name:     N,N-Dimethyl-a-phenylbenzeneacetamide

     Synonyms:    N,N-Dimethyl-2,2-diphenylacetainide
    Molecular
      Formula:     C16H17NO
    Structure:
H    O
 I    H     >
C - C - N
            x
                                         CH,
     Chemical Properties

       Molecular Weight:    239.32

       Vapor Pressure:

       Boiling Point:  decomposes at 210C

       Density:    1.17at23.3C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
                          Physical State:    Solid

                          Vapor Density:

                          Melting Point:    134.5 to 135.5C

                          Solubility:    Slightly soluble (H2O)
                                       (0.026 gm/100 ml at 27 C)
             Relatively resistant to decomposition by ultraviolet irradiation
     Safety Hazard:
                                            AII-180

-------
                                                                         Diphenamid
Annual U.S.
 Production:   3.0xl06lbs.

Fraction of
 Dispersion:   Estimated as 1.0

Release Rate (million Ibs/yr):   3-
                              PRODUCTION DATA
Consumption:

Fraction of Pro-
 duction Lost:
0.015
                                 TOXICITY DATA
Acute Toxicity
                          293 mg/kg
                          600 mg/kg
                          500 mg/kg
                          800 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
          Emetic
          May produce convulsions
 Animal
  rat
  mouse
  mouse
  mouse
      Route
     oral
     oral
     intrapeiitoneal
     subcutaneous
TLV:
                                     AII-181

-------
Diphenyl
    CAS Number:  92-52-4

    Chemical Name:   Biphenyl

    Synonyms:   Diphenyl
    Molecular
      Formula:  C12H10
                                      CHEMICAL  NAME
    Structure:
     Chemical Properties

       Molecular Weight:  154.22

       Vapor Pressure:    0.017 psiat71.1C

       Boiling Point:  255.9C at 760 mm

       Density:    0.8660 at 20C/4C
       Octanol/Water Parti-
         tion Coefficient:
4.09
                       Physical State:  Solid

                       Vapor Density: 5.31

                       Melting Point:  71C

                       Solubility:  Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
          Fire-slight
                                            AII-182

-------
                                                                                Diphenyl
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                                         Consumption:

                                         Fraction of Pro-
                                          duction Lost:
Acute Toxicity
      LDSO
 Non-lethal Acute Effects:
      Irritant effects
         TDLo
                                  TOXICITY DATA
                   3280 mg/kg
                   2400 mg/kg
                   2500 mg/kg
                   4400 /ug/m3

Paralysis and convulsions
 Animal
rat
rabbit
rabbit
human
  Route
oral
oral
skin
                   inhalation
Chronic Toxicity

   U.S. Occupational Standard: (air): TWA 0.2 ppm
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                         TLV:  0.2 ppm
                                       AII-183

-------
Diphenylamine
                                     CHEMICAL NAME
    CAS Number:  122-39-4

    Chemical Name:   Diphenylamine

    Synonyms:  Phenylaniline
               Anilinobenzene
               DPA
    Molecular
      Formula:  C^HuN
    Structure:   /    VN-<(   }>
                 \:	ff  H   v	y
     Chemical Properties

       Molecular Weight:  169.24

       Vapor Pressure:    1 mm at 108.3C

       Boiling Point:  302C
        Density:   1.160 at 22 C/20 C

        Octanol/Water Parti-
         tion Coefficient:  3.50
Physical State: Solid

Vapor Density: 5.82

Melting Point: 52.85C

Solubility:  Insoluble (H2O)
     Environmental Persistence

        BOD:

        Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
          Fire-slight
          Disaster hazard-dangerous-toxic fumes
                                             AII-184

-------
                                                                       Diphenylamine
                               PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
     LDLo               3000mg/kg            rat                 oral
                          250 mg/kg            mouse              intraperitoneal

Non-lethal Acute Effects:
     CNS depression
     Cardiac arrhythmia
     Liver and kidney damage
     Hypertension
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Recognized carcinogen


   Mutagenicity:

   Teratogenicity:                                TLV:    1 mg/m3
      TDi_,0:              7500 mg/kg             pregnant rat          oral
   Other Chronic Effects:
                                       AII-185

-------
Diphenyl  oxide
                                     CHEMICAL NAME
    CAS Number:  101-84-8

    Chemical Name:   Phenyl ether

    Synonyms:   Diphenyl oxide
                Diphenyl ether
    Molecular
      Formula:
    Structure:
     Chemical Properties

       Molecular Weight:  170.20

       Vapor Pressure:    l mm at 66C

       Boiling Point:   258C at 760 mm

       Density:     1.0728 at 20C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
                    Physical State: Liquid

                    Vapor Density: 5.86

                    Melting Point:  27C

                    Solubility:   Insoluble (H2O)
Reacts with oxidizing materials
     Safety Hazard:
          Fire-moderate
                                            All-186

-------
                                                                       Diphenyl  oxide
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
Acute Toxicity
      LDso

Non-lethal Acute Effects:
      Slight irritant
         TOXICITY DATA


3370 mg/kg
 Animal
rat
Chronic Toxicity

   U.S. Occupational Standard: (air): TWA 1 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:
                      TLV:
   Other Chronic Effects:
      Liver, spleen, kidney, thyroid and gastrointestinal system
Route
 oral
                                       AII-187

-------
Diphenylthiourea
                                     CHEMICAL  NAME
    CAS Number:   102-08-9

    Chemical Name:   Thiocarbanilide
Synonyms:
Molecular
 Formula:
                 Diphenylthiourea
                 N ,N-Dipheny Ithiourea
                 l,3-Diphenyl-2-thiourea

                 Ci3HI2N2S
Structure:
                         N  - C - N
                         H        H
Chemical Properties

   Molecular Weight:  228.33

   Vapor Pressure:

   Boiling Point:  Decomposes

   Density: 1.32at25C

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
                                                    Physical State: Solid

                                                    Vapor Density:

                                                    Melting Point:  148C

                                                    Solubility:  Insoluble (H2O)
    Safety Hazard:
         Disaster hazard-dangerous-toxic fumesSOX
                                           AII-188

-------
                                                                 Diphenylthiourea
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LD5o               500 mg/kg           mouse              intraperitoneal
     LDLo               720 mg/kg           cat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AII-189

-------
Dipropylene glycol
                                     CHEMICAL  NAME
    CAS Number:   106-62-7

    Chemical Name:    Dipropylene glycol

    Synonyms:  2,2'-Dihydroxy  dipropyl ether
    Molecular
      Formula:
                       OH                     OH
                       I                        I
    Structure:   CH3  - C  - CH2  - O - CH2  - C  - CH3
                       I                        I
     Chemical Properties

       Molecular Weight:  134.17                       Physical State: Liquid

       Vapor Pressure:    0.01 mm at 20C              Vapor Density: 4.63

       Boiling Point:   231.8C                        Melting Point:

       Density:    1.0252 at 20C/20C                 Solubility:   Infinite (H2O)

       Octanol/Water Parti-
         tion Coefficient:  -1.23

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard: Fire-slight
                                            All-190

-------
                                                                Dipropylene  glycol
                              PRODUCTION DATA

Annual U.S.
 Production:   67 x 106 Ibs.                       Consumption:
             (1976 capacity)
Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:  0.01S

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     None listed
     (Moderate)
Non-lethal Acute Effects:
      Moderate effects
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AII-191

-------
Dipropylene glycol,  monomethyl ether
                                   CHEMICAL NAME
    CAS Number:  20324-32-7

    Chemical Name:  Dipropylene glycol monomethyl ether

    Synonyms: Dowanol SOB


    Molecular
     Formula: C7Hi6O3
                      OCH3                  OH
                      I                       I
    Structure:   CH3  - C - CH2 - O - CH2 - C  - CH3
                      H                     H
    Chemical Properties

       Molecular Weight:  148.20

       Vapor Pressure:    Negligible

       Boiling Point:   189C

       Density:    0.950 at 25C/4C

       Octanol/Water Parti-
        tion Coefficient:
Physical State:  Liquid

Vapor Density: 5.11

Melting Point^-80C

Solubility:   Infinite (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard: Fire-moderate
                                         All-192

-------
                                  Dipropylene glycol,  monomethyl  ether
                            PRODUCTION DATA

Annual U.S.
 Production:                                Consumption:

Fraction of                                  Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                              TOXICITY DATA

Acute Toxicity              Dosage             Animal              Route
     LD50              7500mg/kg           dog               oral
     LDLo              4900 rag/kg           rat                oral
Chronic Toxicity

   U.S. Occupational Standard: (aii): TWA 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                    All-193

-------
Disodium methanearsonate
                                    CHEMICAL  NAME
    CAS Number:   144-21-8

    Chemical Name:    Methaneaisonic acid, disodium salt

    Synonyms:   DMA
                Disodium methanearsonate
                Crab-e-iad
    Molecular	
     Formula:   CH3As63'2Na"
                      O   ONa
                      II  /
    Structure:   CHo - As
                          ONa
    Chemical Properties

       Molecular Weight:   183.94

       Vapor Pressure:   Very low

       Boiling Point:

       Density:   ca. 1.0

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
Arsinyl
DSMA
Physical State:   Solid

Vapor Density:
Melting Point:   132 to  139C

Solubility:   Very soluble (H2O)
                                          AII-194

-------
                                                 Disodium methanearsonate
Annual U.S.
 Production:    35.0 x 106 Ibs.

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                    Consumption:
                    Fraction of Pro-
                     duction Lost:  0-015
                               TOXICITY DATA
Acute Toxicity
      LDSO
 Dosage
1800mg/kg
 600mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
 Route
oral
oral
                    TLV:
                                    AII-195

-------
Disulfoton


                                     CHEMICAL NAME


    CAS Number:  298-044

    Chemical Name:    Phosphorodithioic O,O-diethyl S-[2-(ethylthio)ethyl] ester

    Synonyms:     Di-Syston
    Molecular
      Formula:   CgHi9O2PS3
                CH3 -  CH2 -  O    S
    Structure:
P -  S  - CH2CH2 - S - CH2CH3
                 CH, -  CH, - O
     Chemical Properties

       Molecular Weight:    274

       Vapor Pressure:

       Boiling Point:   62C at 0.001 mm

       Density:    1.144 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
                 Physical State:     Liquid

                 Vapor Density:

                 Melting Point:

                 Solubility:   Very slightly (H2O) (1:40,000)
     Safety Hazard:
                                            AII-196

-------
                                                                               Disulfoton
Annual U.S.
 Production:

Fraction of
 Dispersion:
                                PRODUCTION DATA
              8.0xl06lbs.                      Consumption:

                                               Fraction of Pro-
              1.0                                 duction Lost:
                                                                0.015
Release Rate (million Ibs/yr):    8.0
                                  TOXICITY DATA
Acute Toxicity
     LD50
                            Dosage
                            6 mg/kg
                         5400 /jg/kg
                         2500 Mg/kg
                            7 mg/kg
                           3.2 mg/kg
                          12.5 mg/kg
                           2.6 mg/kg
                          20.  mg/kg
                                                Animal
                                               rat
                                               rat
                                               rat
                                               mouse
                                               wild bird
                                               male~raT
                                               female rat
                                               male rat
                                                                     Route
                                                                   skin
                                                                   intiaperitoneal
                                                                   unknown
                                                                   intraperitoneal
                                                                   oral
                                                                   oral"   "  ~~
                                                                   oral
                                                                   dermal
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA Mg/m3



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:
                                                TLV:
   Other Chronic Effects:
        Chronic oral:  10 ppm (16 weeks) reduced cholinesterase in rat
                                       All-197

-------
Ditridecylphthalate
                                     CHEMICAL NAME
    CAS Number:    119-06-2

    Chemical Name:    Phthalic acid, ditridecyl ester

    Synonyms:   Ditiidecylphthalate
                DTDP

    Molecular   	
      Formula:   C34Hs8O4
    Structure:
                       O
                       C - O - (CH2)12CH3
                       C - O - (CH2)12CH3
                       II
                       O

    Chemical Properties

       Molecular Weight:  538

       Vapor Pressure:

       Boiling Point:    >285C at 5 mm

       Density:  0.951 at 20C/20C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Physical State:  Liquid

Vapor Density:

Melting Point:   -37 C (pour point)

Solubility:
    Safety Hazard:
          Fire-slight
                                            All-198

-------
                                                             Ditridecylphthalate
                              PRODUCTION DATA

Annual U.S.                  _                              _
 Production:   27.2 x 106 Ibs. (1974)             Consumption:  27.2  x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:   1-0                              duction Lost: 0.015

Release Rate (million Ibs/yr):  24.3 (1972)
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AII-199

-------
Diuroii
                                      CHEMICAL  NAME


    CAS Number:   330-54-1

    Chemical Name:    3-(3,4-Dichlorophenyl)-l,l-dimethylurea

    Synonyms:


    Molecular
      Formula:  C9Hi0Cl2N2O
                    Cl
    Structure:   Cl
     0         CH3
H    II       /
N  - C  - N

               CH,
     Chemical Properties

       Molecular Weight:     233.11

       Vapor Pressure:    2 x 10~7 mm at 30C

       Boiling Point:   180C (decomposes)

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
          Photodecomposition insignificant
                      Physical State:     Solid

                      Vapor Density:

                      Melting Point:  153 to 155C

                      Solubility:  42 ppm at 25C in distilled water
     Safety Hazard:
          Disaster hazard-dangerous-toxic fumes
                                             AII-200

-------
                                                                                    Diuron


                                PRODUCTION DATA
Annual U.S.
 Production:   6.0 x 10 Ibs.                      Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:    Estimated as 1.0                      duction Lost:    0.015

Release Rate (million Ibs/yr):    6-
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
                          437 mg/kg            rat                 oral
                         3400 mg/kg            rat                 oral
                          500 mg/kg            mouse               intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
        Irritant to eyes, nose, throat, and skin
                                        AII-201

-------
Dodecane
                                     CHEMICAL  NAME
    CAS Number:    112-40-3

    Chemical Name:    Dodecane

    Synonyms:   Bihexyl
                Dihexyl

    Molecular
      Formula:   Ci2H26
    Structure:
    Chemical Properties

       Molecular Weight:     170.3

       Vapor Pressure:  1 mm at 478C
       Boiling Point:    213Cat760mm

       Density:  0.749 at 20C/4C

       Octanol/Watef Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Fiie-moderate
Physical State:  Liquid

Vapor Density:  5.96

Melting Point:   -10C

Solubility:   Insoluble (H2O)
                                            All-202

-------
                                                                          Dodecane
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             - TLV:

   Other Chronic Effects:
                                    AII-203

-------
Dodecy I benzene
                                     CHEMICAL NAME
    CAS Number:   25265-78-5

    Chemical Name:    Dodecyl benzene

    Synonyms:  Alkane
               Detergent alkylate

    Molecular
      Formula:  C18H30
    Structure:          -  c12H25
    Chemical Properties

       Molecular Weight:  246.48                      Physical State:  Liquid

       Vapor Pressure: <10 mm at 75C                Vapor Density: 8.47
       Boiling Point:   290C                         Melting Point:

       Density:    0.9                              Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:
          Fire-slight
                                           AII-204

-------
                                                                 Dodecylbenzene
                             PRODUCTION DATA

Annual U.S.
 Production:  523.3 x 106lbs. (1975)              Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:    0.015

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AII-205

-------
Dodecylbenzenesulfonic acid, sodium salt
                                   CHEMICAL  NAME
    CAS Number:  12068-21-2

    Chemical Name:    Dodecylbenzenesulfonic acid, sodium salt

    Synonyms:  Sodium linear alkylatesulfonate (C12)
               Sodium laurylbenzenesulfonic acid

    Molecular
     Formula:   C18H30O3S
                             CH
Structure:
                        (CH2)y
           CH3(CH2)X - C
                        H
                                        O

                                         S - 0<->Na+
                                         n

Chemical Properties

   Molecular Weight:  349.54

   Vapor Pressure:

   Boiling Point:

   Density:

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:  Unreactive toward RO2
                                                  Physical State: Liquid

                                                  Vapor Density:

                                                  Melting Point:

                                                  Solubility:   Soluble (400 gm/1 H2O)
    Safety Hazard:
                                          AII-206

-------
                               Dodecylbenzenesulfonic  acid, sodium  salt
Annual U.S.
 Production:    364.1 x 106 Ibs.

Fraction of
 Dispersion:    1-0

Release Rate (million Ibs/yr): 369.5
                               PRODUCTION DATA
                      Consumption:
                364.1 x 10" Ibs.
                      Fraction of Pro-
                       duction Lost:     0.015
                                 TOXICITY DATA
Acute Toxicity
        LDSO
  Dosage
1260mg/kg
2000 mg/kg
 105 mg/kg
 Animal
rat
mouse
mouse
Non-lethal Acute Effects:
        Skin and mucous membrane irritation
        Increased sensitivity to glucose loads
        Increased liver weight and fasting sugar level
        Decreased growth rate and food consumption
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:  Negative in rat & mouse


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
  Route
oral
oral
intravenous
                                      All-207

-------
Dodecyl  mercaptan
                                     CHEMICAL  NAME
    CAS Number:   112-55-6"

    Chemical Name:    1-Dodecanethiol
    Synonyms:    DDM	
                 Lauryl meicaptan.
Lauiyl mercaptide
N-Dodecyl mercaptan
                 N-dodecyl mercaptan
    Molecular
      Formula:  C12H26S
    Structure:    CH3(CH2)10CH2SH
     Chemical Properties

       Molecular Weight:  202.4

       Vapor Pressure:    Negligible

       Boiling Point:   142 to 145C at 15 mm

       Density:    0.845 at 20C/20C

       Octanol/Water Parti-
         tion Coefficient:
 Physical State:  Liquid

 Vapor Density: 6.98

 Melting Point:  -7.5C

 Solubility:  Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
          Fire-moderate
          Disaster hazard-dangerous-sulfates
                                           AII-208

-------
                                                             Dodecyl mercaptan
                              PRODUCTION DATA

Annual U.S.
 Production:   15 x 106 Ibs.                      Consumption:   15.2 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:   0.98                              duction Lost:. -02

Release Rate (million Ibs/yr):  15.2
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
    LD5Q               309 mg/kg             rat                  oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AII-209

-------
Dodecylphenol
                                     CHEMICAL  NAME
    CAS Number:   1331-57-3

    Chemical Name:    Dodecylphenol
    Synonyms:   Mixture of dodecylphenol isomers
    Molecular
      Formula:  C18H30O
    Structure:    HO
                             -  (CH2)10 - CH3
Chemical Properties

   Molecular Weight:  262.4

   Vapor Pressure:    <10mmat25C

   Boiling Point:  154 to 168C

   Density:     0.94 at 20C/20C

   Octanol/Water Parti-
    tion Coefficient:
                                                    Physical State:  Liquid

                                                    Vapor Density: 9.04

                                                    Melting Point:

                                                    Solubility:  Insoluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:
          Disaster hazaid-moderate-toxic fumes
                                           All-210

-------
                                                                      Dodecylphenol
                               PRODUCTION DATA
Annual U.S.
 Production:    17.4 x 106 Ibs.

Fraction of
 Dispersion:    1-0

Release Rate (million Ibs/yr):    17.9
                      Consumption:  17.4 x 10 Ibs.

                      Fraction of Pro-
                       duction Lost: 0.03
                                 TOXICITY DATA
Acute Toxicity
     LDso
Non-lethal Acute Effects:
      Strong irritant
  Dosage
2140 mg/kg
5000 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
rabbit
  Route
oral
skin
                      TLV:
                                      All-211

-------
Dodecyl sulfate, sodium  salt
                                     CHEMICAL NAME


    CAS Number:    151-21-3

    Chemical Name:  Sulfuric acid monododecyl ester sodium salt
    Synonyms:   Dodecyl sulfate, sodium salt
                Lauryl sodium sulfate
                SDS
    Molecular
     Formula:   C12H2sO4S'Na
    Structure:   CH3(CH2)ioCH2 - OSO3-Na
    Chemical Properties

       Molecular Weight:    289.44

       Vapor Pressure:   Negligible

       Boiling Point:

       Density:

       Octanol/Water Parti-
        tion Coefficient:    1.60

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
 Sodium dodecyl sulfate
 Sodium lauryl sulfate
    Safety Hazard:
Physical State:  Solid

Vapor Density:

Melting Point:
Solubility:   Soluble (H2O)
                                           All-212

-------
                                                Dodecyl sulfate, sodium salt
                             PRODUCTION DATA

Annual U.S.
 Production:  26.8 x 106 Ibs.                     Consumption:    26.8 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:  1-0                               duction Lost:   0.03

Release Rate (million Ibs/yr):  27.6
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LD50             1300mg/kg            rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AII-213

-------
Dodecyl  sulfate, triethanolamine  salt
                                    CHEMICAL NAME



    CAS Number:   139-96-8

    Chemical Name:   Sulfuricacid, monododecyl ester, compd. with 2,2',2"-nitrilotris[ethanol] (1:1)

    Synonyms:     Triethanolamine lauryl sulfate
    Molecular
     Formula:  C18H4iNO7S
Structure:   CH3(CH2)10CH2 - O -
    Chemical Properties

       Molecular Weight:     415.59

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
                                            N - (CH2CH2OH)3
                                            H
    Safety Hazard:
                                              Physical State:

                                              Vapor Density:

                                              Melting Point:

                                              Solubility:
Liquid or paste
                                          AII-214

-------
                                   Dodecyl  sulfate, triethanolamine salt
                             PRODUCTION DATA

Annual U.S.
 Production:  16.1 x 106 Ibs.                    Consumption:  16.1 x 106 Ibs.

Fraction of                                   Fraction of Pro-
 Dispersion:    Estimated as 1.0                    duction Lost:    0.03

Release Rate (million Ibs/yr):    16.5
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                    All-215

-------
Dursban
                                       CHEMICAL  NAME


    CAS Number:     2921-88-2

    Chemical Name:   Phosphoiodithioic acid, O,O-diethyl-O-(3,5,6-trichloro-2-pyridinyl)ester

    Synonyms:    O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)phosphorothioate
    Molecular
      Formula:
    Structure:
Cl

Cl
Cl        OC2H5
       x
O - P

     S ^ OC2H5
     Chemical Properties

        Molecular Weight:    349.5

        Vapor Pressure:   1.87 x 10"5 mm

        Boiling Point:

        Density:

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
                                Physical State:   Solid

                                Vapor Density:

                                Melting Point:    41 to 43C

                                Solubility: "VeFy~sl!ghtly~(H2~6) (OXHJ02 gm/100 ml)
     Safety Hazard:
            Disaster hazard-dangerous-chlorides, parathion
                                             AII-216

-------
                                                                                 Dursban
Annual U.S.
 Production:
5.Ox ICTlbs.
                               PRODUCTION DATA
Consumption:
Fraction of
 Dispersion:   Estimated as 1.0

Release Rate (million Ibs/yr):   5.0
                                Fraction of Pro-
                                 duction Lost:   0.015
Acute Toxicity
       LDSO
                                  TOXICITY DATA
            Dosage
           145 mg/kg
           202 mg/kg
           150 mg/kg
          2000 mg/kg
           500 mg/kg
            27 mg/kg
            24 mg/kg
            16 mg/kg
            76 mg/kg
             8 mg/kg
 Animal
 rat
 rat
 rat
 rabbit
 guinea pig
 pigeon
 chicken
 quail
 duck
 wild bird
 Route
oral
skin
unreported
skin
unreported
oral
oral
oral
oral
oral
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                TLV:
                                       AII-217

-------
Dyfonate
                                      CHEMICAL  NAME
    CAS Number:    944-22-9

    Chemical Name:     Ethylphosphonodithioic acid, O-ethyl,S-phenyl ester

    Synonyms:    O-Ethyl-S-phenylethylphosphodithioate


    Molecular
      Formula:     C10H,5OPS2
                     C2H5  - O
    Structure:
     Chemical Properties

        Molecular Weight:    246.34

        Vapor Pressure:

        Boiling Point:

        Density:

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
Physical State:    Liquid

Vapor Density:

Melting Point:    100C at 0.3 mm Hg.

Solubility:
     Safety Hazard:
            Disaster hazarddangerous-phosphates
                                             AII-218

-------
                                                                             Dyfonate

                              PRODUCTION DATA
Annual U.S.
 Production:     2.0 x 106 Ibs.                     Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:  Estimated as 1.0                      duction Lost:   0.015

Release Rate (million Ibs/yr):  2.0
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
       LDSO               3mg/kg              rat                 oral
                         147 mg/kg              rat                 skin
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AII-219

-------
Endosulfan
                                       CHEMICAL  NAME


    CAS Number:    115-29-7

    Chemical Name:  l)4,5,6)7,7-Hexachloro-5-norbornene-2,3-dimethanol,cyclic sulfite

    Synonyms:   Thiodan
                 6,7,8,9,10,10-Hexachloro-l,5,5a,6,9,9a-hexahydro-6,9-methano-2,
                    3,4-benzo (e)-dioxathiepin-3-oxide
    Molecular    C9H6C16O3S
      Formula:
    Structure:
                             CKU-O
                                      S = 0
                            CH,-O
     Chemical Properties

        Molecular Weight:   406.91
Physical State:   solid
        Vapor Pressure:  (no measurable pressure at 75C)    Vapor Density:

        Boiling Point:                                   Melting Point:   106C

        Density:   1.745 at 20C/20C                    Solubility:   Nearly insoluble (H2O)

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
     Safety Hazard:
                                             AII-220

-------
                                                                             Endosulfan
                               PRODUCTION DATA

Annual U.S.
 Production:   2.0 x 106 Ibs.                      Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:    1.0                                 duction Lost:    0.015

Release Rate (million Ibs/yr): 2.0
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
     LD50               18 mg/kg              rat                 oral
                         74 mg/kg              rat    ,             skin
                         40 mg/kg              rat                 unreported
                        359 mg/kg              rabbit              skin
                         34 mg/kg              duck               oral
                         35 mg/kg              wild bird            oral

     affects central nervous system
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA: 100 jjg/m3 (skin)
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                       AII-221

-------
Endothal


                                     CHEMICAL  NAME


    CAS Number:   145-73-3

    Chemical Name:  7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic acid

    Synonyms:      3,6-Endohexanhydiophthalic acid
    Molecular
      Formula:
                         O

                /r^_
    Structure:
                         O
    Chemical Properties

       Molecular Weight:  232.16                      Physical State:  Solid

       Vapor Pressure:                                Vapor Density:
       Boiling Point:  Slowly decomposes above 90C      Melting Point:  ca. 144C when heated rapidly
                	                                           	(decomposes) _
       Density:  1.431                                Solubility:   Soluble (10 gm/100gmH2O at 20C)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                           AII-222

-------
                                                                               Endotha!
Annual U.S.
 Production:

Fraction of
 Dispersion:
2.0 x 106 Ibs.
1.0
                               PRODUCTION DATA
Consumption:
Fraction of Pro-
 duction Lest:  0.015
Release Rate (million Ibs/yr):  2.0
                                 TOXICITY DATA
Acute Toxicity
            Dosage
       38 to 51 mg/kg
           5T mg/kg
           750 mg/kg
           100 mg/kg
           50 mg/kg
            5 mg/kg
           200 mg/kg
            5 mg/kg
           250 mg/kg
Animal
rat
rat
rat
rabbit
mouse
dog
rabbit
rabbit
guinea pig
Route
oral
oral
skin
skin
oral
intravenous
oral
intravenous
oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
        Irritant to skin, nose, eyes, and throat
        Greatest occupational hazard-eye irritation
           by burning of exposed tissues
                                TLV:
                                       AII-223

-------
Epichlorohydrin
                                     CHEMICAL NAME


    CAS Number:   106-89-8

    Chemical Name:  l-Chloro-2,3-epoxypropane

    Synonyms:   a: 3-Chloro-l,2-propylene               (3 :  3-Chloro-l-oxacyclobutane
                                                        3-Chlorooxetane

    Molecular
      Formula:   C3HSC1O
                    O                         CH2-O
                  / I                           II,
    Structure:    CH2CHCH2C1             Cl - CH - CH2
    Chemical Properties  (a)

       Molecular Weight:   92.53                       Physical State:   Liquid

       Vapor Pressure:     16.8 mm at 25C             Vapor Density:  3.29

       Boiling Point:    117.9C                        Melting Point:   -48C

       Density:  1.1801 at 20C/4C                   Solubility:   Slightly soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-moderate
                   Disaster hazard-dangerous, toxic fumes-phosgene
                                            AII-224

-------
                                                                      Epichlorohydrin
                               PRODUCTION DATA
Annual U.S.    __	
 Production:    495 x 106 Ibs. (1974)

Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr):
                     Consumption:    ca. 396 x 10  Ibs.

                     Fraction of Pro-
                      duction Lost:   0.015
                                 TOXICITY DATA
Acute Toxicity
       LC
         50
 Non-lethal Acute Effects:
      Eye effects:
      TD,
         Lo
 Dosage
 90 mg/kg
238 mg/kg
155 mg/kg
100 mg/kg
250 ppm (4 hours)
 20ppm
Chronic Toxicity

   U.S. Occupational Standard:
      TWA : 5 ppm
Carcinogenicity:
    Neoplastic effects:"


Mutagenicity:

Teratogenicity:

Other Chronic Effects:
                           19 mg/kg
                          720 mg/kg
Animal
rat
mouse
mouse
rabbit
rat
human
                      mouse
                      mouse
                                               TLV:
                                                                  Route
                                                                oral
                                                                oral
                                                                intraperitoneal
                                                                skin
                                                                inhalation
                    inhalation
                    inhalation
                    subcutaneous
                                       AII-225

-------
Eptam
                                      CHEMICAL NAME
    CAS Number: 759-94-4

    Chemical Name:   S-Ethyldipiopylthiocaibamate

    Synonyms:    Dipropylthiocarbamic acid, S-ethyl ester
                 S-Ethyl-N,N-propylthiocarbamate
    Molecular
      Formula:
C9H19NOS
    Structure:    CH3 - CH2  - S -  C - N
                           CH2  - CH2 - CH3

                           CH2  - CH2 - CH3
     Chemical Properties

       Molecular Weight: 189.35

       Vapor Pressure:

       Boiling Point:   232C at 760 mm

       Density:  0.9546 at 30C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
                                   Physical State:    Liquid

                                   Vapor Density:

                                   Melting Point:

                                   Solubility:  Very slightly "soluble (H2O)
     Safety Hazard:
                                             AII-226

-------
                                                                                    Eptam

                                PRODUCTION DATA
Annual U.S.
 Production:   5 x 106 Ibs.                       Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:    1.0                                duction Lost:    0.015

Release Rate (million Ibs/yr): 5.0
                                  TOXICITY DATA

Acute Toxicity                Dosage               Animal               Route
      LD50               1630 rag/kg            rat                 oral
                          750 mg/kg            mouse               oral
                          112mg/kg            cat                 oral
                          146 mg/kg            rabbit  .             skin
                          100 mg/kg            wild bird             oral
                          200 mg/m3/(3 hours)    rat                 inhalation
                          400 mg/m /(3 hours)    cat                 inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:    Neoplastic


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                       AII-227

-------
Ethane
                                     CHEMICAL NAME
    CAS Number:  74-84-0

    Chemical Name:     Ethane

    Synonyms:   Bimethyl
                Dimethyl
                Ethyl hydride
    Molecular    	
      Formula:   C2Hft
Me Me
Methylmethane
    Structure:   CH3 - CH3
    Chemical Properties

       Molecular Weight:   30.07
       Vapor Pressure:   255 mm at 21 C

       Boiling Point:    -88.63C

       Density:     0.446 at 0C/4C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Physical State:  Gas

Vapor Density:  1.04

Melting Point:  -183.3C

Solubility:   Insoluble (H2O)
    Safety Hazard:   Fiie-dangerous
                   Explosion-moderate
                                            AII-228

-------
                                                                                Ethane

                              PRODUCTION DATA
Annual U.S.               	                                -    -
 Production:    5,485 x 106lbs. (1973)              Consumption:   5,485 x 106 Ibs.
Fraction of                                     Fraction of Pro-
 Dispersion:    0                                duction Lost:   0.01
Release Rate (million Ibs/yr):  54.9~

                                TOXIC ITY DATA
Acute Toxicity               Dosage              Animal              Route
Chronic Toxicity
   U.S. Occupational Standard:

   Carcinogenicity:

   Mutagenicity:
   Teratogenicity:                                TLV:
   Other Chronic Effects:
                                      AII-229

-------
Ethanoiamine
                                     CHEMICAL  NAME
    CAS Number:  141-43-5

    Chemical Name:  2-Aminoethanol

    Synonyms:  2-Aminoethanol
               Monoethanolamine
               (3-Ethanolamine
    Molecular
      Formula:  C2H7NO
Colamine
    Structure:    H2N  - CH2  - CH2  - OH
    Chemical Properties

       Molecular Weight:  61.08

       Vapor Pressure:    6 mm at 60C

       Boiling Point:    170C at 760 mm

       Density:    1.0180 at 20C/4C

       Octahol/Water Parti-
         tion Coefficient:  1.71

    Environmental Persistence
       BOD:    75% of theoretical after 30 days at 20 C at 25 mg/ml
                Total theoretical oxygen demand = 2.62 (gm/gm)
       Atmospheric Reactivity:
          Reacts with oxidizing materials
     Safety Hazard:  Fire-moderate
 Physical State: Liquid

 Vapor Density: 2.11

 Melting Point:  10.3C

 Solubility:  Infinite (H2O)
                                            All-230

-------
                                                                      Ethanolamine
                              PRODUCTION DATA
AnnuafU.S.	
 Production:   293 x 106 Ibs. (1973)

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                      Consumption:   266 x 10b Ibs. (1974)

                      Fraction of Pro-
                       duction Lost:  0.01S
                                TOXICITY DATA
Acute Toxicity
     LDso
  Dosage
2100mg/kg
 981 mg/kg
2537 mg/kg
 Animal
rat
rat
mouse
Chronic Toxicity

   U.S. Occupational Standard:  (ait)  TWA: 3 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
  Route
oral
intraperitoneal
subcutaneous
                                      AII-231

-------
Ethion


                                       CHEMICAL  NAME

     CAS Number:   563-12-2
     Chemical Name:    Phosphorodithioic acid, 5,5'-methylene O,O,O',O'-tetraethyl ester

     Synonyms:  0,0,0',0'-Tetraethyl-S-S-methylene diphosphorodithioate
                Tetiaethyl-S-S'-methylenedi(phosphorothiolothionate)
                Ethyl methylene phosphorodithioate
     Molecular
      Formula:
                          S                    S
                          II  .                  II
    Structure:    (C2H5O)2P - S  - CH2 - S  - P(OC2H5)2
     Chemical Properties

        Molecular Weight:  384.5                          Physical State: Liquid

        Vapor Pressure:                                  Vapor Density:

        Boiling Point:                                    Melting Point: -13C

        Density:     1.220 at 20C/4C                    Solubility:   Slightly (H2O)

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:   Gradually oxidizes in air
     Safety Hazard:
                                              MI-232

-------
Annual U.S.
 Production:   2.0 x 106 Ibs.
Fraction of
  Dispersion:
1.0
Release Rate (million Ibs/yr): 2.0
                                PRODUCTION DATA
                                  Consumption:

                                  Fraction of Pro-
duction Lost:   0.015
                                                                                      Ethion
Acute Toxicity
                    TOXICITY DATA

              Dosage                Animal
           13 mg/kg               rat
           62 mg/kg               rat
           26 mg/kg               rat
           55 mg/kg               rat
           35 mg/kg               mouse
          890 mg/kg               rabbit
           45 mg/kg               wild bird
Non-lethal Acute Effects:
      Central nervous system
     _   TDLo            16 mg/kg
      Blood effects^
         TDLo           100 jig/kg
                                  infant

                                  human
                     Route
                  oral
                  skin
                  intraperitoneal
                  unreported
                  intraperitoneal
                  skin
                  oral
                  oral

                  oral
Chronic Toxicity

   U.S. Occupational Standard:
      EPA: Farm worker field re-entry
   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                  TLV:
                                        AII-233

-------
Ethyl  acetate
                                      CHEMICAL  NAME
    CAS Number:   141-78-6

    Chemical Name:    Acetic acid, ethyl ester

    Synonyms:   Acetic ester
                Ethylacetic ester
                Ethyl etharate
    Molecular
      Formula:   C4HgO2
Ethyl esters of acetic acid
                           O
    Structure:   CH3.- C
                           O - CH2 - CH3
     Chemical Properties

       Molecular Weight:   88.10

       Vapor Pressure:  92.5 mm at 25C

       Boiling Point:   77.06C at 760 mm

       Density:   0.8946 at. 25C/4C

       Octanol/Water Parti-
         tion Coefficient:   2.68

     Environmental Persistence
       BOD:   69% of theoretical after 20 days'at 20C
               Total theoretical oxygen demand = 1.82 gm/gm
Physical State:   Liquid

Vapor Density:  3.04

Melting Point:   -83.578C
Solubility:  Soluble (89 gm/1 H2O)
        Atmospheric Reactivity:
    Safety Hazard:
                                            All-234

-------
                                                                         Ethyl acetate
                               PRODUCTION DATA
Annual U.S.
 Production:    212.0 x 106 Ibs.

Fraction of
 Dispersion:  0.91

Release Rate (million Ibs/yr):  196.1
                     Consumption:   212.0 x 106 Ibs.

                     Fraction of Pro-
                       duction Lost:  0.015
                                  TOXICITY DATA
Acute Toxicity
       LD50
       LCLo
 Dosage
5000 mg/kg
 709 mg/kg
3000 mg/kg
4930 mg/kg
3000 mg/kg
1600 mg/kg
  31 mg/m3 (1 hour)
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA : 400 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
       Irritating to mucous surfaces and eyes
       Dermatitis
       Congestion of liver and kidneys
       Anemia, leucocytosis
Animal
rat
mouse
cat
rabbit
guinea pig
rat
mouse
                     TLV:  400 ppm
 Route
subcutaneous
intraperitoneal
subcutaneous
oral
subcutaneous
inhalation
inhalation
                                        AII-235

-------
Ethyl  acetoacetate
                                     CHEMICAL NAME
     CAS Number:  141-97-9

     Chemical Name:   Acetoacetic acid, ethyl ester
    Synonyms:   3-Oxo-butanoic acid, ethyl ester
                Diacetic ether

    Molecular
      Formula:  C6H10O3
                       O           O
                       II           II
    Structure:   CH3  - c - CH2  - C - 6 -  CH2CH3
     Chemical Properties

       Molecular Weight:  130.15                       Physical State:  Liquid

       Vapor Pressure:    1 mm at 28.5C               Vapor Density:  4.48

       Boiling Point:   180.8C                        Melting Point:  <-80C

       Density:  1.0282 at 20C/4C                    Solubility:  Very soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:  1.23

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard: Fire-moderate
                                            All-236

-------
                                                               Ethyl acetoacetate
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal               Route
     LDSO               3980mg/kg            rat                   oral

Non-lethal Acute Effects:
     Local irritant to skin and mucous membranes
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AII-237

-------
Ethyl  acrylate
                                      CHEMICAL  NAME
    CAS Number:  140-88-5

    Chemical Name:   Acrylic acid, ethyl ester

    Synonyms: Ethyl acrylate
               Ethyl propenoate
               Propenoic acid, ethyl ester
    Molecular
      Formula:
                               O
                               II
    Structure:    CH2 =  CH - C - OCH2CH3
     Chemical Properties

       Molecular Weight:  100.13                       Physical State:  Liquid

       Vapor Pressure: 38.5 mm at 25C                 Vapor Density: 3.45

       Boiling Point:  99.8C                          Melting Point:  -71.2C

       Density: 0.9234 at 20C/4C                     Solubility:  Slightly soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
          Fire-dangerous
          Explosion-dangerous
                                              AII-238

-------
                                                                          Ethyl acrylate
Annual U.S.
  Production:

Fraction of
  Dispersion:

Release Rate (million Ibs/yr):
                                PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                        duction Lost:
                                  TOXICITY DATA
Acute Toxicity
  Dosage
 830 mg/kg
1950 mg/kg
 420 mg/kg
2000 ppm (4 hours)
1204ppm (7 hours)
1204 ppm (7 hours)
 Animal
rat
rabbit
rabbit
rat
rabbit
guinea pig
  Route
oral
skin
oral
inhalation
inhalation
inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air)  TWA: 25 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:
                       TLV: 25ppm
   Other Chronic Effects:
      Irritation of gastrointestinal tract
      Degenerative changes in cardiac, hepatic, renal, and splenic tissues
      Skin and eye irritant
                                        AII-239

-------
Ethyl  alcohol
                                      CHEMICAL  NAME
    CAS Number:  64-17-5

    Chemical Name:  Ethanol

    Synonyms:    Absolute ethanol
                  Anhydrous alcohol
                  Dehydrated alcohol
    Molecular
      Formula:  C2H6O
Ethyl hydrate
Ethyl Hydroxide
Methyl caibinol
Alcohol
    Structure:     CH3CH2OH
     Chemical Properties

       Molecular Weight: 46.07

       Vapor Pressure:   54.3 mm at 25C

       Boiling Point:  78.5C

       Density:    0.7893 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient: 0.38

     Environmental Persistence

       BOD:   84% at 20C for 20 days
               Total theoretical 2.10 gm/gm
       Atmospheric Reactivity:
         Reacts with oxidizing materials
 Physical State:    Liquid

 Vapor Density:   1-59

 Melting Point:    -117.3C

 Solubility: Infinite (H2O)
    Safety Hazard:
          Firedangerous
         Cxplosion-moderate
                                            AII-240

-------
                        Ethyl alcohol
PRODUCTION DATA
Annual U.S.

Production: 1850.6 x 106 Ibs.
Fraction of
Dispersion: 0.35
Release Rate (million Ibs/yr)

Acute Toxicity
LDSO




LDL
-------
Ethylamine
                                     CHEMICAL NAME
    CAS Number:    75-04-7

    Chemical Name:     Ethanamine

    Synonyms:    Aminoethane
                 Monoethylamine

    Molecular
      Formula:    C2H7N
    Structure:   CH3~- CH2- NH2
    Chemical Properties

       Molecular Weight:   45.08

       Vapor Pressure:  1094.24 mm at 25C

       Boiling Point:    16.6 at 760 mm

       Density:   0.6829 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:   -0.27
Physical State:   Liquid

Vapor Density:

Melting Point:   -81C

Solubility:    Infinite (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
           Fire-dangerous
                                           AII-242

-------
                                                                            Ethylamine
                               PRODUCTION DATA
Annual U.S.
 Production:    45.9 x 106 Ibs.
Fraction of
 Dispersion:
0.30
Consumption:   45.9 x 106 Ibs.

Fraction of Pro-
 duction Lost:  0.015
Release Rate (million Ibs/yr):   14.4
                                 TOXICITY DATA
Acute Toxicity
      LDSO
      LDLo
           390 mg/kg
           400 mg/kg
          3000 ppm (4 hours)
 Non-lethal Acute Effects:
       Irritation of eyes, skin, and respiratory tract
Chronic Toxicity

   U.S. Occupational Standard:   (air)  TWA 10 ppm



   Carcinogenicity:
 Animal
 rabbit
 rat
 rat
 Route
skin
oral
inhalation
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                TLV:
                                       AII-243

-------
Ethyl sec-amyl ketone
                                    CHEMICAL  NAME
    CAS Number:   6137-11-7
    Chemical Name:   4-Methyl-3-heptanone
    Synonyms:   Ethyl sec-amyl ketone


    Molecular
      Formula:  C8H16O
                             O
                             II
    Structure:   CH3 - CH2  - C - CH - CH2 - CH2  - CH3

                                 CH,
    Chemical Properties

       Molecular Weight:   128.22                     Physical State:

       Vapor Pressure:                               Vapor Density:

       Boiling Point:                                Melting Point:

       Density:                                     Solubility:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                           All-244

-------
                                                          Ethyl  sec-amyl ketone
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                     .               Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
      LD50              3500mg/kg             rat                 oral
                        3800 mg/kg             mouse              oral
                        2500 mg/kg             guinea pig           oral
                        3484 ppm (8 hours)      rat                 inhalation
                        3484 ppm (8 hours)      mouse              inhalation
Chronic Toxicity

   U.S. Occupational Standard: (air)   TWA: 25 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AII-245

-------
Ethyl benzene

                                      CHEMICAL  NAME
    CAS Number:  100-41-4

    Chemical Name:   Ethylbenzene
    Synonyms:  Ethylbenzol
                Phenylethane

    Molecular
      Formula: C8H10
    Structure:
     Chemical Properties

        Molecular Weight:  106.17                       Physical State: Liquid

        Vapor Pressure:    9.63 mm at 25C               Vapor Density: 3.66

        Boiling Point:   136.2C at 760 mm               Melting Point:  -94.97C

        Density:    0.8670 at 20C/4C                  Solubility:  Insoluble (H2O)

        Octanol/Water Parti-
         tion Coefficient:  3.15

     Environmental Persistence

        BOD:   3% of theoretical after 5 days at 20C
               Total theoretical oxygen demand 3.16 gm/gm
        Atmospheric Reactivity:
          Occurs in atmosphere in small quantities
          Unreactive to RO^ and O3
          Reacts with oxidizing materials
          Activity toward OH: t^ = 0.8 days, product is hydroxyethylbenzene

     Safety Hazard:
          Fire-moderate
                                            AII-246

-------
                                                                          Ethyl benzene
                                PRODUCTION DATA
Annual U.S.
 Production:

Fraction of
 Dispersion:
6920 x 106 Ibs..
(1975:4,008.2xl06lbs.)

0.02
Consumption:   6713 x 106 Ibs.

Fraction of Pro-
 duction Lost:  0.01
Release Rate (million Ibs/yr): 203.5
Acute Toxicity
      LDSO
      LCLo

Non-lethal Acute Effects:
   Irritant
      TC,
         Lo
   Narcosis
   Dermatitis
                    TOXICITY DATA

              Dosage               Animal
           3500 mg/kg             rat
           4000 ppm (4 hours)       rat
           1000 ppm           '    guinea pig
           1000 ppm
                                  human
                      Route
                    oral
                    inhalation
                    inhalation
                                                     subcutaneous
Chronic Toxicity

   U.S. Occupational Standard:  TWA: 100 ppm



   Carcinogenicity: Negative for inhalation and ingestion


   Mutagenicity:

   Teratogenicity:                                 TLV:  100 ppm

   Other Chronic Effects:
      Blood disorders after repeated doses
      Conjunctivitis and corneal erosion
      Vertigo-2000 ppm (5 minutes)"
                                        AII-247

-------
Ethyl  bromide
                                     CHEMICAL  NAME
    CAS Number:  74-96-4

    Chemical Name:   Bromoethane

    Synonyms:   Bromic ether
                Hydrobromic ether

    Molecular
      Formula:   C2H5Br
                                                    Physical State: Volatile liquid

                                                    Vapor Density: 3.76

                                                    Melting Point:  -118.6C

                                                    Solubility:  Slightly soluble (H2O)
    Structure:    CH3CH2Br
Chemical Properties

   Molecular Weight:  108.98

   Vapor Pressure:    482.76 mm at 25C

   Boiling Point:  38.4C

   Density:  1.451 at 20C/4C

   Octanol/Water Parti-
    tion Coefficient:  1.74

Environmental Persistence

   BOD:
       Atmospheric Reactivity:
          Reacts with oxidizing materials to produce hydrobromic acid and bromide
     Safety Hazard:
          Explosion-moderate
          Disaster hazarddangerous, toxic fumes of bromine
                                            AII-248

-------
                                                                      Ethyl bromide
                              PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal               Route
                        2200 ppm             guinea pig           inhalation
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA: 200 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:    200 ppm

   Other Chronic Effects:
      Irritant to mucous membranes, especially lungs, liver, and kidney damage
                                      AI1-249

-------
Ethyl butyl  ketone
                                     CHEMICAL NAME
    CAS Number:   106-35-4


    Chemical Name:    3-Heptanone


    Synonyms:  Ethyl butyl ketone
    Molecular
      Formula:  C7H14O
    Structure:    CH3 - CH2 - C -
     Chemical Properties


       Molecular Weight: 114.19


       Vapor Pressure: <1 mm at 20C


       Boiling Point:   148C


       Density: 0.8183at20C/4C


       Octanol/Water Parti-
         tion Coefficient:


     Environmental Persistence


       BOD:


       Atmospheric Reactivity:
    Safety Hazard:
          Fire-moderate
Physical State: Liquid


Vapor Density: 3.93


Melting Point:  -39C


Solubility:   Insoluble (H2O)
                                            All-250

-------
                                                               Ethyl butyl ketone
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal               Route
     LD50              2760mg/kg            rat                oral
     LCL(j              2000 ppm (4 hours)      rat                inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA: SO ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:   50 ppm

   Other Chronic Effects:
                                      AII-251

-------
Ethyl  cellulose
                                      CHEMICAL  NAME
    CAS Number:     9004-57-3

    Chemical Name:     Cellulose, ethyl ether
    Synonyms:
    Molecular
      Formula:
Ethyl ether of cellulose
Cellulose ethyl
Cellulose ethylate
(Exact composition unknown or undetermined)
    Structure:  (Exact composition unknown or undetermined)
     Chemical Properties

       Molecular Weight:

       Vapor Pressure:

       Boiling Point:
        Density:    1.07 to 1.18

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOO:

        Atmospheric Reactivity:
     Safety Hazard:
                                   Physical State:    Solid

                                   Vapor Density:

                                   Melting Point:    240 to 255C

                                   Solubility:    Insoluble (H20)
                                             AII-252

-------
                                                                    Ethyl cellulose
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AII-253

-------
Ethyl  chloride
                                      CHEMICAL  NAME
    CAS Number:   75-00-3

    Chemical Name:    Chloroethane

    Synonyms:   Muriatic acid
                Hydrochloric ether

    Molecular
      Formula:   C2H5C1
    Structure:   CH3CH2 - Cl
     Chemical Properties

       Molecular Weight:   64.52

       Vapor Pressure:    20mmat21C

       Boiling Point:   12.27Cat760rnm

       Density:  0.8978 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
           Reacts with oxidizing materials
           RO2: 1^ = 2000 years
           OH: t% = 10 years
           O3: t^= 1 year
     Safety Hazard:
           Fire-very dangerous
           Explosion-very dangerous
           Disaster hazard -very dangerous, toxic fumes of phosgene
Physical State:   Liquid or gas

Vapor Density:   2.22
Melting Point:   -136.4C

Solubility:   Slightly soluble
            (0.574gm/100mlH2O)
                                             All-254

-------
                                                                        Ethyl  chloride
                               PRODUCTION DATA
Annual U.S.        -          	
 Production:    660 x 106 Ibs. (1974)

Fraction of
 Dispersion:    O.OS

Release Rate (million Ibs/yr):  34.5
                      Consumption:    660 x 10  Ibs.

                      Fraction of Pro-
                       duction Lost:  0.01
Acute Toxicity

Non-lethal Acute Effects:
      CNS	
        TCLO
      Irritant to eyes
        TOXICITY DATA

  Dosage              Animal
13,000 ppm
human
                      Route
                   inhalation
      Kidney, heart, and liver damage
      Subcutaneous tissue edema
      Leucocytosis
Chronic Toxicity

   U.S. Occupational Standard: (aii) TWA: 1000 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:  1000 ppm
                                       AII-255

-------
Ethyl  chloroacetate
                                     CHEMICAL NAME
    CAS Number:  105-39-5

    Chemical Name:  Chloroacetic acid, ethyl ester

    Synonyms:     Ethylchloroethanoate
                  Qilpio^aceticjcid, ethyl ester
                  Ethyl chloroacetate
    Molecular
      Formula:  C4H7C1O2
    Structure:   Cl - CH2 - C  - OCH2CH3
                            II
                            O



    Chemical Properties

       Molecular Weight:  122.55

       Vapor Pressure:    4.93 mm at 25C

       Boiling Point:  143.6C

       Density:    1.1585 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:
Physical State: Liquid

Vapor Density: 4.3

Melting Point: -26C

Solubility: Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
          Fire-moderate
          Disaster hazarddangerous, toxic fumeschlorides
                                             AII-256

-------
                                                             Ethyl chloroacetate
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route


Non-lethal Acute Effects:
     Local irritant to eyes
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AII-257

-------
Ethyl cyanoacetate
                                     CHEMICAL  NAME
    CAS Number:    105-56-6

    Chemical Name:    Cyanoacetic acid, ethyl ester

    Synonyms:   Malonic ethyl ester nitrite
    Molecular
      Formula:   CSH7NO2
                                O
                                II
    Structure:    N = C  - CH2  - C - OCH2 - CH3
    Chemical Properties

       Molecular Weight:  113.1                       Physical State:   Liquid

       Vapor Pressure:  67.8C                         Vapor Density:  3.9

       Boiling Point:    206C                         Melting Point:   -22.5C

       Density:  1.0654 at 20C/4C                    Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-slight
          Disaster hazard-dangerous, toxic fumes of cyanides
                                           AII-258

-------
                                                             Ethyl cyanoacetate
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal               Route
      LD5o               750 mg/kg            mouse              intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AII-259

-------
Ethylene
                                      CHEMICAL  NAME
    CAS Number:   74-85-1

    Chemical Name:    Ethylene

    Synonyms:  Acetene
                Ethene

    Molecular
      Formula:  C2H4
    Structure:   H2C = CH2
     Chemical Properties

       Molecular Weight:   28.06

       Vapor Pressure:  34,200 mm at 0C

       Boiling Point:   -103.9C at 760 mm

       Density:  0.99267 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:
       Atmospheric Reactivity:
             Reported in ail in concentrations of 0.012 to 0.25 ppm
             Activity: unresistive to ROj; ti^ with 0)3 = <4 hours
             Activity toward OH: tvj = 1 day
     Safety Hazard:   Fire-dangerous
                    Explosion-moderate
Physical State:   Gas

Vapor Density:   0.98

Melting Point:   -169C
Solubility:   Insoluble (H2O)
                                             AII-260

-------
                                                                                    Ethylene



                                 PRODUCTION DATA

Annual U.S.
  Production:    20,852.1 x 106 Ibs.                   Consumption:   20,852.1 x 106 Ibs.

Fraction of                                        Fraction of Pro-
  Dispersion:    0.01                                 duction Lost:  0.015

Release Rate (million Ibs/yr): 521.3



                                   TOXICITY DATA

Acute Toxicity                Dosage                Animal                Route
      Paralysis at high concentrations
      Malfunctions of heart
      Depressed activity of sympathetic ganglion of upper neck (cat)
      Increased blood coagulation time (mouse)
     . Disturbances of the electrical activity of the brain (dog)
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                  TLV:

   Other Chronic Effects:    Lung inflamation; histopathological changes in liver and cerebellum (rabbit);
      peripheral leucopenia; reduced cellularity of the bone marrow, hypertension, inhibition of
      chlolinesterase activity, disruption of subordination chronaxy (rat).
                                          AII-261

-------
Ethylene carbonate
                                     CHEMICAL  NAME


    CAS Number:   96-49-1
    Chemical Name:    l,3-Dioxolan-2-one

    Synonyms:   Glycol carbonate
                Dioxolone-2

    Molecular
      Formula:   C3H4O3
    Structure:
-0\
   Vo
                     o
                      I/
    Chemical Properties

       Molecular Weight:  88.06                      Physical State:   Solid

       Vapor Pressure:  0.01 mm at 20C                Vapor Density:  3.04
       Boiling Point:   248C at 760 nun               Melting Point:   39 to 40C
       Density:   1.322 at 39C/4C                   Solubility:   Infinite (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-slight
                                             AII-262

-------
                                                            Ethylene carbonate
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    auction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AII-263

-------
Ethylene  chlorohydrin
                                     CHEMICAL  NAME
    CAS Number:   107-07-3

    Chemical Name:     2-Chloroethanol

    Synonyms:   Ethylene chlorohydrin
                (}-Chloroethyl alcohol
                Glycol chlorohydrin
    Molecular
      Formula:   C2H5ao
    Structure:    Cl - CH2 - CH2OH
     Chemical Properties

       Molecular Weight:   80.52                       Physical State:  Liquid

       Vapor Pressure:  7.65 mm at 25C                Vapor Density:  2.78

       Boiling Point:   ~128^~atT~60mm              Melting Point:  -67.5C
        Density:   1.2003 at 20C/4C                   Solubility:   Infinite (H2O)

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fire-moderate
                   Disaster hazard-dangerous-toxic fumes-phosgene
                                            AII-264

-------
                                                              Ethylene chlorohydrin
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                                PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                        duction Lost:
                                  TOXICITY DATA
Acute Toxicity
      LD50                5 80 mg/kg
                           84 mg/kg
                           81 mg/kg
                           81 mg/kg
                           56 mg/kg
                           67 mg/kg
                          110 mg/kg
                           71 mg/kg
      Ingestion has caused human death
      LDLo
      LCSO
      LCLo

Non-lethal Acute Effects:
      Skin-TDLo
      Nausa
      Irritation of eyes
      Convulsions
  40 mg/kg
1450 mg/kg
 100 mg/kg
  70 mg/kg
 250 mg/kg
 385 mg/m3
  32 ppm (4 hours)
3000mg/m3(112minu

5000 mg/kg
    Animal
   rat
   rat
   mouse
   mouse
   rabbit
   rabbit
   guinea pig
   guinea pig

   rat
   mouse
   rabbit
   guinea pig
   frog
   mouse
   rat
tes) guinea pig

   human
Chronic Toxicity

   U.S. Occupational Standard:  (air) 5 ppm


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
  Route
oral
subcutaneous
oral
intraperitoneal
skin
intraperitoneal
oral
intraperitoneal

intraperitoneal
skin
intravenous
skin
subcutaneous
inhalation
inhalation
inhalation

skin
                      TLV: 5 ppm (skin)
                                        AII-265

-------
Ethylenediamine
                                     CHEMICAL  NAME
    CAS Number:    107-15-3

    Chemical Name:    Ethylenediamine

    Synonyms:   1,2-Ethanediamine
                1,2-Diaminoe thane

    Molecular
      Formula:   C2H8N2
    Structure:    H2N - CH2  - CH2  - NH2
    Chemical Properties

       Molecular Weight:  60.10

       Vapor Pressure:  13.04 mm at 25C
       Boiling Point:    116.5C at 760 mm

       Density:  0.8994 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:    70% of theoretical after 20 days at 20C
                Total theoretical oxygen demand = 3.7 gm/gm
       Atmospheric Reactivity:   Reacts with oxidizing materials
Physical State:  Liquid

Vapor Density:  2.07

Melting Point:  8.5C
Solubility:   Very soluble (H2O)
    Safety Hazard:   Fire-moderate
                                            AII-266

-------
                                                                    Ethylenediamine
                               PRODUCTION DATA
Annual U.S.
 Production:   54.4 x 106 Ibs.

Fraction of
 Dispersion:   0.50

Release Rate (million Ibs/yr): 22.5
                      Consumption:  43.3 x 10 Ibs.

                      Fraction of Pro-
                       duction Lost: 0.015
                                 TOXICITY DATA
Acute Toxicity
     LD50
Non-lethal Acute Effects:
     Irritant
        TCLo
  Dosage
 760 mg/kg
 424 mg/kg
 730 mg/kg
 470 mg/kg
4000 ppm (8 hours)
 Animal
rat
mouse
rabbit
guinea pig
rat
200 ppm
                      human
   Route
oral
subcutaneous
skin
oral
inhalation
                   inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 10 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:   Allergen
                        Dermatitis
                        Asthmatic
                      TLV: 10ppm
                                       AII-267

-------
Ethylene dibromide
                                     CHEMICAL NAME
    CAS Number:    106-93-4

    Chemical Name:    1,2-Dibromoethane

    Synonyms:   Ethylene dibromide
                Glycol dibiomide
                EDB
    Molecular
      Formula:   C2H4Br2
                     H   H
    Structure:   Br
    Chemical Properties

       Molecular Weight:   187.88

       Vapor Pressure:  14.54 mm at 25C
       Boiling Point:    131.36Cat 760 mm

       Density:  2.1707 at 25C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:
       Atmospheric Reactivity:   Reacts with oxidizing materials	
                              Photochemical degradation:  decomposes
Physical State:  Heavy liquid

Vapor Density:  6.48

Melting Point:   9?79C~

Solubnity:    Slightly (H2O)
            (0.431gm/100mlat30C)
    Safety Hazard:
                                            AII-268

-------
                                                                 Ethylene dibromide
                               PRODUCTION DATA
Annual U.S.
 Production:  315.5 x 106 Ibs.

Fraction of
 Dispersion:   0.95

Release Rate (million Ibs/yr): 304.4
                       Consumption:  315.5 x 106 Ibs.
                       Fraction of Pro-
                        duction Lost:
                                          0.015
                                  TOXICITY DATA
Acute Toxicity
   Dosage
 140 mg/kg
 146 mg/kg
  55 mg/kg
 300 mg/kg
 110 mg/kg
  79 mg/kg
 250 mg/kg
 400 ppm (2 hours)
6425 ppm (1 hour)
 400 ppm (3 hours)
 Animal
rat
mouse
rabbit
rabbit
guinea pig
chicken
mouse
rat
rabbit
guinea pig
   Route
oral
unreported
oral
skin
oral
oral
oral
inhalation
inhalation
inhalation
Chronic Toxicity

   U.S. Occupational Standard: (air): TWA 20 ppm
                           ceiling 30 ppm
                           peak 50 ppm/5 mins/8 hours

   Carcinogenicity:   Positive, 10 week incubation, mouse
   Mutagenicity:  Positive in bacteria

   Teratogenicity:
                       TLV:
   Other Chronic Effects:
Abnormal sperm
Reduced sperm count
Skin irritation and blisters
Lung stimulation
                                       AII-269

-------
Ethylene  dichloride
                                     CHEMICAL  NAME
    CAS Number:   107-06-2

    Chemical Name:    1,2-Dichloroethane

    Synonyms:   Ethylene dichloride
                Ethylene chloride

    Molecular
      Formula:   C2H4C12
    Structure:    Cl  - CH2  - CH2 - Cl
     Chemical Properties

       Molecular Weight:   99.0

       Vapor Pressure:  84.42 mm at 25C
       Boiling Point:    83.5C at 760 mm

       Density:   1.257 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:  Fire-dangerous
                   Explosion-moderate
Physical State:  Liquid

Vapor Density:  3.35

Melting Point:  -35.5C

Solubility:    Slightly soluble (H2O)
            (0.43 gm/~100 ml)
                                            AII-270

-------
                                                                 Ethylene  dichloride
                               PRODUCTION DATA
Annual U.S.       . _		
 Production:   9, 293 x 106 Ibs. (1973)

Fraction of
 Dispersion:    0.05

Release Ratal million Ibs/yr): 540.2
                      Consumption:  ca. 8,921.3 x 106 Ibs.

                      Fraction of Pro-
                        duction Lost: 0.015
Acute Toxicity
     LDSO
      LCLo
Non-lethal Acute Effects:
      Central nervous system
        TCLo
Chronic Toxicity
         TOXICITY DATA

                       Animal
 860 mg/kg            rabbit
 680 mg/kg            rat
 845 mg/kg            human
 600 mg/kg            rat
 500 mg/kg            rat
 600 mg/kg            mouse
 250 mg/kg            mouse
 380 mg/kg            mouse
2000 mg/kg            dog
 175 mg/kg            dog
1200 mg/kg            rabbit
1000 ppm (4 hours)      rat
5000 mg/m3 (2 hours)    mouse
3000 ppm (7 hours)      rabbit
3000 ppm (7 hours)      pig
1500 ppm (7 hours)      guinea pig
4000 ppm (hour)        human
   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
  ^air) TWA 50 ppm
   Ceiling 100 ppm
   Peak 200 ppm/5 minute/3 hours
                      TLV:
  Route
oral
oral
oral
intraperitoneal
subcutaneous
oral
intraperitoneal
subcutaneous
oral
intravenous
subcutaneous
inhalation
inhalation
inhalation
inhalation
inhalation
inhalation
                                       AII-271

-------
Ethylene  glycol
                                     CHEMICAL NAME
    CAS Number:   107-21-1

    Chemical Name:    Ethylene glycol

    Synonyms:   1,2-Ethyanediol
                Ethylene alcohol

    Molecular  .
      Formula:   C2H6O2
    Structure:   HO -  CH2 - CH2  - OH
     Chemical Properties

       Molecular Weight:   62.1                        Physical State:   Liquid

       Vapor Pressure:  0.05 mm at 20C                Vapor Density:  2.14
        Boiling Point:    198C at 760 mm                Melting Point:   -11.5C
        Density:   1.1088 at 20C/4C                   Solubility:   Infinite (H2O)

        Octanol/Water Parti-
         tion Coefficient:   -1-88

     Environmental Persistence

        BOD:     13% Theoretical

        Atmospheric Reactivity:    Reacts with oxidizing materials
     Safety Hazard:   Fire-slight
                    Explosion-moderate
                                            AII-272

-------
                                                                       Ethylene glycol
                                PRODUCTION DATA

Annual U.S.
 Production:   3,761.1 x 106 Ibs.                   Consumption:    3,242 x 106 Ibs. (1974)

Fraction of                                       Fraction of Pro-
 Dispersion:    0.70                                duction Lost: 0.01S

Release Rate (million Ibs/yr):    2,526.3
                                  TOXICITY DATA

Acute Toxicity                Dosage               Animal               Route
     LD50               2000mg/kg            cat                 oral
                         6610mg/kg            guinea pig            oral
     LDLo               1500 mg/kg            human              oral
                         2700 mg/kg            mouse              skin
                         1000 mg/kg            rabbit               intraperitoneal

Non-lethal Acute Effects:
      CNS stimulation followed by depression, if ingested
      Kidney damage
      Very toxic in particulate form
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:
      Neoplastic effects: TD]_,0  4 gm/kg             mouse              skin

   Mutagenicity:

   Teratogenicity:                                 TLV:

   Other Chronic Effects:    Slight irritant
                                        AII-273

-------
Ethylene glycol, diacetate
                                     CHEMICAL  NAME
    CAS Number:    111-55-7

    Chemical Name:    Ethylene glycol, diacetate

    Synonyms:   Ethylene diacetate
                Gylcol diacetate

    Molecular
      Formula:   C6H10O4
    Structure:
            O
            II
CH2 - O  - C - CH3
I
CH2 - O  - C - CH3
            II
            O
     Chemical Properties

       Molecular Weight:   146.14

       Vapor Pressure:  1 mm at 38.3C
       Boiling Point:   190C at 760 nun
       Density:   1.1063 at 20 C/20C

       Octanol/Water Parti-
         tion Coefficient:  0.38
                                    Physical State:  Liquid

                                    Vapor Density:  5.04

                                    Melting Point:  -31.0C

                                    Solubility:    Very soluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing material
     Safety Hazard:   Fire-moderate
                                           AII-274

-------
                                                    Ethylene glycol, diacetate
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
      LD5o              1070 mg/kg           mouse              intarpeiitoneal
                       .4940 mg/kg           guinea pig           oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                      AII-275

-------
Ethylene glycol,  dibutyl ether
                                    CHEMICAL  NAME
    CAS Number:    112-48-1

    Chemical Name:     1,2-Dibutoxyethane

    Synonyms:    Dibutyl cellosolve
    Molecular
     Formula:
    Structure:   CH3 - (CH2)3 - O - CH2 - CH2 - O - (CH2)3 - CH3
    Chemical Properties

       Molecular Weight:    174.29

       Vapor Pressure:   0.09 mm at 20C

       Boiling Point:    203.1C at 760 mm

       Density:    0.8374 at 20C/20C

       Octanol/Water Parti-
     .  tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:   Liquid

Vapor Density:

Melting Point:    -69.1C

Solubility:    Slightly soluble (H2O)
                                          AII-276

-------
                                             Ethylene  glycol, dibutyl  ether
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                    AII-277

-------
Ethylene glycol,  diethyl  ether
                                    CHEMICAL  NAME
    CAS Number:    16484-86-9

    Chemical Name:    Ethylene glycol, diethyl ether

    Synonyms:   1,2-Diethoxyethane
                Diethyl cellosolve

    Molecular
      Formula:   C6H14O2
    Structure:
    Chemical Properties

       Molecular Weight:  118.18

       Vapor Pressure: 9.4 mm at 20C

       Boiling Point:   123.5C at 760 mm

       Density:  0.8484 at 20C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:  Liquid

Vapor Density:

Melting Point:   -74C

Solubility:    Insoluble (H2O)
                                           AII-278

-------
                                               Ethylene glycol, diethyl  ether
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal               Route
     LD50              4390mg/kg            rat                oral
                       2440mg/kg            guinea pig          oral
                       9000 ppm (14 hours)     rat                inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AII-279

-------
Ethylene glycol,  dimethyl ether
                                    CHEMICAL  NAME
    CAS Number:   534-15-6

    Chemical Name:    Dimethyl acetal acetaldehyde

    Synonyms:  Ethylene glycol, dimethyl ether
               GDME
               1,2-Dimethoxyethane
    Molecular
      Formula:  C4H10O2
    Structure:   CH3  - O  - CH2CH2 - O - CH3
    Chemical Properties

       Molecular Weight:   90.14                       Physical State:   Liquid

       Vapor Pressure:  77.52 mm at 25C               Vapor Density:  3.11
       Boiling Point:   83 to 84C at 760 mm            Melting Point:  -58C
       Density:  0.8629 at 20C/4C                   Solubility:   Soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-dangerous
                   Explosion-dangerous
                                           AII-280

-------
                                           Ethylehe glycol,  dimethyl ether
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                            PRODUCTION DATA
            Consumption:

            Fraction of Pro-
             duction Lost:
Acute Toxicity
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
TOXICITY DATA

             Animal
            TLV:
Route
                                     AII-281

-------
Ethylene glycol,  monoacetate
                                    CHEMICAL  NAME
    CAS Number:   542-59-6

    Chemical Name:    Ethylene glycol, monoacetate

    Synonyms:   Glycol monoacetate
                1,2-Ethanediol, monoacetate
                Hydroxyethyl acetate
    Molecular
      Formula:   C4HgO3
                       O
                       II
    Structure:    CH3  - C - OCH2CH2OH
    Chemical Properties

       Molecular Weight:   104.10                     Physical State:   Liquid

       Vapor Pressure:                                Vapor Density:  3.59

       Boiling Point:   181 to 182C                   Melting Point:

       Density:   1.108 at 15C                        Solubility:   Soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-moderate
                                           AII-282

-------
                                              Ethylene  glycol, monoacetate
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal             Route
                       1310mg/kg           mouse             intraperitoneal
                       3800 mg/kg           guinea pig          oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AII-283

-------
Ethylene glycol, monobutyl ether
                                    CHEMICAL  NAME
    CAS Number: 111-76-2

    Chemical Name:    2-Butoxyethanol

    Synonyms:  Ethylene glycol, monobutyl ether
               Butyl cellosolve
    Molecular
     Formula:
    Structure:   CH3(CH2)3  - O - CH2CH2OH
    Chemical Properties

       Molecular Weight:   118.17                     Physical State:   Liquid

       Vapor Pressure:  0.76 mm at 20C                Vapor Density:  4.07

       Boiling Point:    171.2C                       Melting Point:

       Density:   0.9027 at 20C/4C                   Solubility:   Soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-moderate
                                          AII-284

-------
                                            Ethylene glycol,  monobutyl ether
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
      LDSO
      LCSO

Non-lethal Acute Effects:
   Irritant
      TDLo
  Dosage
1480 mg/kg
 550 mg/kg
 340 mg/kg
1230 mg/kg
 536 mg/kg
1130 mg/kg
 320 mg/kg
 560 mg/kg
 280 mg/kg
1200 mg/kg
 230 mg/kg
 700 ppm (2 hours)
 500 ppm (4 hours)
 195 ppm (8 hours)
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 50 ppm


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
rat
rat
mouse
mouse
mouse
rabbit
rabbit
rabbit
guinea pig
guinea pig
mouse
rat
human
  Route
oral
intraperitoneal
intravenous
oral
intraperitoneal
intravenous
oral
skin
intravenous
oral
skin
inhalation
inhalation
inhalation
                     TLV: 50 ppm (skin)
                                      All-285

-------
Ethylene glycol,  monoethyl  ether
                                    CHEMICAL  NAME
    CAS Number:   110-80-5

    Chemical Name:   2-Ethoxyethanol

    Synonyms:   Cellosolve solvent	
                Ethylene glycol, monoethyl ether

    Molecular
      Formula:   C4H10O2
    Structure:   CH3 CH2OCH2CH2OH
    Chemical Properties

       Molecular Weight:   90.12

       Vapor Pressure:  3.8 mm at 20C

       Boiling Point:   135.1C

       Density:   0.9360 at 15C/15C

       Octanol/Water Parti-
        tion Coefficient:
Physical State:   Liquid

Vapor Density:  3.10

Melting Point:   <37.7C (pour point)

Solubility:   Soluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
    Safety Hazard:   Fire-moderate
                   Explosion-moderate
                                            AII-286

-------
                                            Ethylene  glycol, monoethyl ether
                               PRODUCTION DATA
Annual U.S.
 Production:  205.4 x 106 Ibs

Fraction of
 Dispersion:   0.97

Release Rate (million Ibs/yr):  197.5
                      Consumption:  200.4 x 106 Ibs.

                      Fraction of Pro-
                       duction Lost: 6.015
                                 TOXICITY DATA
Acute Toxicity
     LD50
      LC
        Lo
3000 mg/kg
4300 mg/kg
1710 mg/kg
3100 mg/kg
1400 mg/kg
4000 ppm (4 hours)
1820ppm
 Animal
rat
mouse
mouse
rabbit
guinea pig
rat
mouse
  Route
oral
oral
intraperitoneal
oral
oral
inhalation
inhalation
Non-lethal Acute Effects:
      Local irritant
      Exposure to vapor produces congestion and edema of the lungs and
      congestion of the kidney
      Eye irritation observed in humans
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 200 ppm


   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV: 200 ppm (skin)
                                       AII-287

-------
Ethylene glycol, monoethyl ether acetate
                                   CHEMICAL NAME
    CAS Number:   111-15-9

    Chemical Name:    2-Ethoxyethanol acetate

    Synonyms:  Ethylene glycol, monoethyl ether acetate
    Molecular
     Formula:   C6Hi2O3
                      O
                      II
    Structure:   CH3 - C -  OCH2 - CH2 - OCH2CH3
    Chemical Properties

       Molecular Weight:   132.17                    Physical State:  Liquid

       Vapor Pressure:  1.2mmat20C                Vapor Density:  4.72

       Boiling Point:    156.3C                      Melting Point:   -61.7C

       Density:  0.9748 at 20C/20C                 Solubility:    Soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-moderate
                  Explosion-moderate
                                          AII-288

-------
                               Ethylene glycol,  monoethyl  ether acetate
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
                                TOXICITY DATA
Acute Toxicity
     LD50
     LC
        Lo
1420 mg/kg
1910mg/kg
1500 ppm (4 hours)
 Animal
mouse
guinea pig
rat
  Route
intraperitoneal
oral
inhalation
Non-lethal Acute Effects:
      Irritation of eyes and respiratory tract
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppm (skin)



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV: 100 ppm
                                    AII-289

-------
Ethylene glycol,  monohexyl  ether
                                    CHEMICAL NAME
    CAS Number:   112-25-4

    Chemical Name:    2-(Hexyloxy) ethanol

    Synonyms:  Ethylene glycol, monohexyl ether
               Hexyl cellosolve

    Molecular
      Formula:  C8H,8O2
    Structure:   HO - CH2 - CH2-O - (CH2)5CH3
    Chemical Properties

       Molecular Weight:   146.22                     Physical State:  Liquid

       Vapor Pressure:  0.05 mm at 20C                Vapor Density:  5.04

       Boiling Point:                                Melting Point:   -50.1C

       Density:   0.8894 at 20C/20C                  Solubility:   Soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Fire-moderate
                                          AII-290

-------
                                        Ethylene glycol, monohexyl ether
                            PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage             Animal             Route
     LD50              1480mg/kg           rat                oral
                       896 mg/kg           rabbit             skin
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                   AII-291

-------
Ethylene glycol, monomethyl  ether
                                    CHEMICAL NAME


    CAS Number:    109-86-4

    Chemical Name:    2-Methoxyethanol

    Synonyms:   Ethylene glycol, monomethyl ether       Ethoxyacetate
                Cellosolve acetate
                Methyl cellosolve
    Molecular
      Formula:   C3H8O2
    Structure:    CH3OCH2CH2OH
    Chemical Properties

       Molecular Weight:   76.09                      Physical State:  Liquid

       Vapor Pressure:  6.2at20C                    Vapor Density:  2.62

       Boiling Point:   124.5C                      Melting Point:   -81.5C

       Density:   0.9660 at 20C/4C                  Solubility:    Soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-moderate
                                           AII-292

-------
                                          Ethylene  glycol, monomethyl  ether
                               PRODUCTION DATA
Annual U.S.
 Production:   137.4 x 106 Ibs. (1968)

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                    Consumption:

                    Fraction of Pro-
                     duction Lost: 0.015
Acute Toxicity
      LCSO
      LCLo

Non-lethal Acute Effects:
      Central nervous system
         TCLo
25 ppm
                                 TOXICITY DATA
                    Animal
                   rat
                   rat
                   rabbit
                   rabbit
                   guinea pig
                   rabbit
                   rat
                      human
2460 mg/kg
2140 mg/kg
 890 mg/kg
1340 mg/kg
 950 mg/kg
1340 mg/kg
2000 ppm (4 hours)
  Route
oral
intravenous
oral
skin
oral
inhalation
inhalation
                                         inhalation
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:
                    TLV: 25 ppm (skin)
   Other Chronic Effects:
         Disturbances of hemopoietic system with or without neurological signs or symptoms
         Severe aplastic anemia with tremors and marked mental dullness               |
         Reduction of number of blood platelets and macrocytic anemia
                                       AII-293

-------
Ethylene glycol, monomethyl ether  acetate
                                    CHEMICAL  NAME
    CAS Number:   110-49-6

    Chemical Name:    2-Methoxyethanol acetate

    Synonyms:  Ethylene glycol, monomethyl ether acetate
               Cellosolve acetate
    Molecular
      Formula:
                      O
                      II
    Structure:    CH3 - C - OCH2CH2OCH3
    Chemical Properties

       Molecular Weight:   118.13                     Physical State:  Liquid

       Vapor Pressure:  1.2mmat20C                 Vapor Density:  4.07

       Boiling Point:   145C                        Melting Point:  -65.1C

       Density:   1.0067 at 20C/20C                  Solubility:   Soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Fire-moderate
                                          AII-294

-------
                            Ethylene glycol,  monomethyl ether acetate
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
                               TOXICITY DATA
Acute Toxicity
     LD50

     LCLo
3390 mg/kg
1250 mg/kg
7000 ppm (4 hours)
 Animal
rat
guinea pig
rat
Non-lethal Acute Effects:
     Irritation of eyes and respiratory tract
     Nausea and vomiting
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 25 ppm (skin)



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     fLV: 25ppm
  Route
oral
oral
inhalation
                                    AII-295

-------
Ethylene glycol,  monooctyl ether
                                    CHEMICAL  NAME
    CAS Number:   10020-43-6

    Chemical Name:    2-(Octyloxy)ethanol

    Synonyms:     Ethylene glycol monooctyl ether


    Molecular
      Formula:  Ci0H22O2
    Structure:    CH3(CH2)? - O - CH2 - CH2 - OH
    Chemical Properties

       Molecular Weight:     174.28                   Physical State:    Liquid

       Vapor Pressure: 0.02 mm at 20 C                Vapor Density:

       Boiling Point:  228.3C                       Melting Point:

       Density:  0.8859 at 20C                       Solubility:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Fire-slight
          Explosion-moderate
                                           AII-296

-------
                                         Ethylene  glycol, monooctyl ether
                            PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage             Animal             Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                    AII-297

-------
Ethylene glycol,  monophenyl ether
                                    CHEMICAL  NAME
    CAS Number:    122-99-6

    Chemical Name:    2-Phenoxyethanol

    Synonyms:   Ethylene glycol, monophenyl ether
                Phenyl cellosolve
    Molecular
      Formula:
    Structure:
O - CH2CH2 - OH
     Chemical Properties

       Molecular Weight:   138.2

       Vapor Pressure:  <0.01 mm at 20C

       Boiling Point:   244.9C

       Density:   1.1094 at 20C/20C

       Octanol/Water Parti-
         tion Coefficient:   1.16
                            Physical State:  Liquid

                            Vapor Density:  4.76

                            Melting Point:   14C

                            Solubility:    Soluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
    Safety Hazard:   Fire-slight
                   Explosion-moderate
                                           AII-298

-------
                                      Ethylene  glycol, monophenyl  ether
                            PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity          ,    Dosage             Animal             Route
     LDSO              1260mg/kg            rat               oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                    AII-299

-------
Ethylene glycol, monopropyl ether
                                   CHEMICAL NAME
    CAS Number:   2807-30-9

    Chemical Name:   2-Propoxyethanol

    Synonyms:  Propyl cellosolve
               Ethylene glycol monopropyl ether

    Molecular
     Formula:  CsHi2O2
    Structure:   HO  - CH2 -  CH2 - O - CH2 - CH2 - CH3
    Chemical Properties

       Molecular Weight:  104.14

       Vapor Pressure:

       Boiling Point:   150C at 743 mm

       Density:    0.9112 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Fire-moderate
Physical State:     Liquid

Vapor Density:

Melting Point:

Solubility:     Soluble (H2O)
                                          AII-300

-------
                                       Ethylene  glycol,  monopropyl ether
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LD50              4890mg/kg           rat                oral
                        940 mg/kg           rabbit             skin
     LCLo              2000 ppm (4 hours)     rat                inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                    AII-301

-------
Ethyleneimine
                                     CHEMICAL NAME
    CAS Number:    151-56-4

    Chemical Name:    Ethylenimine

    Synonyms:   Aziridine
    Molecular
      Formula:   C2H5N
    Structure:
                   N
                    I
                   H
    Chemical Properties

       Molecular Weight:  43.07

       Vapor Pressure:  160 mm at 20C
       Boiling Point:    56Cat756mm

       Density:  0.832 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:   Fire-dangerous
                   Explosion-dangerous
Physical State:  Liquid

Vapor Density:  1.48

Melting Point:   -78C
Solubility:   Infinitely soluble (H2O)
                                            AII-302

-------
                                                                         Ethyleneimine
Annual U.S.
 Production:
              5 x 10 Ibs.
                                PRODUCTION DATA
 Consumption:
Fraction of
 Dispersion:  0.01

Release Rate (million Ibs/yr): 0.08
                                                Fraction of Pro-
                                                 duction Lost:  -015
                                  TOXICITY DATA
Acute Toxicity
                            Dosage
                            15 mg/kg
                          3800 mg/kg
                            15 mg/kg
                            14 mg/kg
                            25 ppm (8 hours)
                            25 ppm (8 hours)
                           400 mg/m3
                          2200 ppm (10 mins)
      LCSO


 Non-lethal Acute Effects:
      Skin irritation
      Skin sensitization
      Necrosis of cornea
      Nausea and vomiting
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 1 mg/m3 (skin)
 Animal
 rat
 rat
 mouse
 guinea pig
 rat
 guinea pig
 mouse
 rat
  Route
oral
intiaperitoneal
unreported
skin
inhalation
inhalation
inhalation
inhalation
   Carcinogenicity:
      TDLo

   Mutagenicity:
      TDLo
   Teratogenicity:

   Other Chronic Effects:
                            20 mg/kg (67 days)    rat
                           235 mg/kg (76 weeks)   mouse
                     subcutaneous
                     oral
                             6 mg/kg
 mouse
JLV:    	
 Odor perception: 2 ppm
                     intraperitoneal
                                        AII-303

-------
Ethylene  oxide
                                      CHEMICAL  NAME
    CAS Number:   75-21-8

    Chemical Name:    Ethylene oxide

    Synonyms:   1,2-Epoxyethane
                Oxiiane

    Molecular
      Formula:   C2H4O
    Structure:
     Chemical Properties

       Molecular Weight:   44.05                        Physical State:   Gas

       Vapor Pressure:  1475 mm at 25C                Vapor Density:  1.52

       Boiling Point:   13.5Cat 746 mm                Melting Point:   -111.3C

       Density:  0.8711 at 20C/20C                   Solubility:   Soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:    31% of theoretical after 10 days at 70C at 100 mg/ml
                Total theoretical oxygen demand = 1.82 gm/gm
       Atmospheric Reactivity:
                Unreactive to ROj or Oj
                Activity towards OH: ti^ = 1.6 days
                Reacts with oxidizing materials
                Hydrolyzes rapidly: ti^ = 2.5 days at pH 7

     Safety Hazard:   Fire-dangerous
                   Explosion-severe
                                            AII-304

-------
                                                                        Ethylene  oxide
                                PRODUCTION DATA
Annual U.S.
 Production:  3,961.8 x 106 Ibs.

Fraction of
 Dispersion: 0.01

Release Rate (million Ibs/yr): 98.8
Consumption:   3,934.0 x 106 Ibs.

Fraction of Pro-
 duction Lost:  0.015
                                  TOXICITY DATA
Acute Toxicity
      LDSO
      LC
        so
 Animal
rat
guinea pig
lat
mouse
dog
                           Dosage
                          330 mg/kg
                          270 mg/kg
                         1462 ppm (4 hours)
                          836 ppm (4 hours)
                          960 ppm (4 hours)
     LCLo               7000 ppm (150 minutes)  guinea pig
     LC                15,000 to 10,000 ppm (air)
Non-lethal Acute Effects:
     Irritant to eyes and mucous membranes
     Pulmonary edema at high concentrations
     Reduced motor response-CNS damage
     Skin burns
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 50 ppm



   Carcinogenicity:    Positive carcinogen in mice-various tumors-oral
Mutageniciry:
   Increased chromosomal aberrations
                         30 mg/rh3
   Teratogenicity:

   Other Chronic Effects:
mammal   <
TLV:  50ppm
                                                                  Route
                                                                oral
                                                                oral
                                                                inhalation
                                                                inhalation
                                                                inhalation
                                                                inhalation
                                                                inhalation
                                                                   inhalation
                                        AII-305

-------
Ethyl  ether
                                      CHEMICAL NAME
    CAS Number:   60-29-7

    Chemical Name:    Ethyl ether
    Synonyms:   Ether
                 Ethyl oxide

    Molecular
      Formula:  C4Hi0O
 Anaesthesia ethei
 Diethyl ether
 l,l'-Oxybis-e thane
    Structure:   CH3 - CH2 -  O -  CH2 - CH3
     Chemical Properties

       Molecular Weight:   74.12

       Vapor Pressure:  442 mm at 20C

       Boiling Point:   34.5C

       Density:  0.7135 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:   0.93
Physical State:   Volatile liquid

Vapor Density:  2.56

Melting Point:   -116.2C

Solubility:   Slightly soluble (H2O)
     Environmental Persistence

        BOD:     1% theoretical

        Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
           Fire-dangerous
           Explosion-severe
                                             All-306

-------
                                                                           Ethyl ether
                               PRODUCTION DATA

Annual U.S.	                                             	
 Production: 103.2 x 10* Ibs. (1969)                 Consumption:   102. x 106 Ibs.

Fraction of                                     Fraction of Pro-
 Dispersion:  0.50                                 duction Lost:  0.015

Release Rate (million Ibs/yr):  35.7
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
       LDSO               1700 mg/kg            rat                 oral
       LDLo               2000 mg/kg            rat                 intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA: 400 ppm



   Carcinogenicity:


   Mutagenicity:
   Teratogenicity:                               TLV:  400 ppm

   Other Chronic Effects:
       CNS depressant
                                       All-307

-------
Ethyl formate
                                     CHEMICAL NAME
    CAS Number:   109-944

    Chemical Name:    Formic acid, ethyl ester

    Synonyms:   Formic ether
                Ethyl formic ester
                Ethyl methanoate
    Molecular
      Formula:   C3H6O2
                    O
    Structure:   H - C  - OCH2CH3
     Chemical Properties

       Molecular Weight:   74.08

       Vapor Pressure:  258.48 mm at 25C
       Boiling Point:    54.5C at 760 mm

       Density:  0.9236 at 20C/20C

       Octanol/Water Parti-
         tion Coefficient:
Physical State:  Liquid

Vapor Density:  2.55

Melting Point:  ^8oT0cf

Solubility:   Soluble (H2O)
     Environmental Persistence

       BOD:    30% of theoretical after 10 days

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
          Fire-dangerous
          Explosion-severe
                                            All-308

-------
                                                                        Ethyl formate
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
                                 TOXICITY DATA
Acute Toxicity
       LD50
       LD
         Lo
 Dosage
1850 mg/kg
2070 mg/kg
1100 mg/kg
8000 ppm (4 hours)
Animal
rat
rabbit
guinea pig
rat
 Route
oral
oral
oral
inhalation
 Non-lethal Acute Effects:
       Irritant to_skin and mucous membranes
       Narcotic at high concentrations
          TCT
           "Lo
" 330 ppm
human
                   inhalation
Chronic Toxicity

   U.S. Occupational Standard:    (air)  TWA: 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:  lOOppm

   Other Chronic Effects:
                                      All-309

-------
Ethylhexanol
                                     CHEMICAL  NAME
    CAS Number:   104-76-7

    Chemical Name:     2-Ethyl-l-hexanol

    Synonyms:   Ethylhexanol
                2-Ethylhexyl alcohol
                Octyl alcohol
    Molecular
      Formula:
                                             CH3
                                             I
                                             CH2
                                             I
    Structure:    CH3 - CH2 - CH2 - CH2 -  CH -  CH2OH
     Chemical Properties

       Molecular Weight:   130.23                      Physical State:  Liquid

       Vapor Pressure:  1 mm at 50C                   Vapor Density:  6.35

       Boiling Point:    130Cat50mm                 Melting Point:   <-76C

       Density:  0.8859 at 20C/20C                  Solubility:   Slightly (1.16 gm/!H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:    86% of theoretical after 20 days at 20C at 10 mg/ml
                Total theoretical oxygen demand =2.95 gm/gm
       Atmospheric Reactivity:
                 Reacts with oxidizing materials
     Safety Hazard:   Fire-moderate
                                            AII-310

-------
                                                                        Ethylhexanol
                              PRODUCTION DATA
Annual U.S.	          	
 Production:    264.7 x 106 Ibs. (1975)

Fraction of
 Dispersion: 0.15

Release Rate (million Ibs/yr): 79.0
                      Consumption:   310.0 x 106 Ibs. (1975)

                      Fraction of Pro-
                       duction Lost:  0.015
                                 TOXlfclTY DATA
Acute Toxicity
      LDSO
      LD
        Lo
 3200 mg/kg
"7380-mg/kg -
 3200 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
rabbit
mouse
                      TLV:
  Route
oral
skin
oral
                                      AII-311

-------
Ethylidene chloride
                                     CHEMICAL  NAME
    CAS Number:    75-34-3

    Chemibal Name:     IJ-Dichloioethane

    Synonyms:   Ethylidene chloride
                Ethylidene dichloiide
                Chlorinated hydrochloric ether
    Molecular
      Formula:   C2H4C12
                      H
                     '  I
    Structure:   CH3  - C - Cl
                     J_
                      a
    Chemical Properties

       Molecular Weight:   98.96

       Vapor Pressure:  230 mm at 25C
       Boiling Point:    57.3C at 760 mm

       Density:   1.174 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:   Fire-dangerous
                   Explosion-moderate
Physical State:   Liquid

Vapor Density:   3.44

Melting Point:   -98C

Solubility:   Sparingly (H2O)
                                           AIJ-312

-------
                                                              Ethylidene chloride
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of           .                         Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LD50               725 mg/kg            rat                oral

Non-lethal Acute Effects:
      Liver injury
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     All-313

-------
Ethyl mercaptan
                                     CHEMICAL  NAME
    CAS Number:   75-08-1

    Chemical Name:    Ethanethiol

    Synonyms:   Ethyl hydtosulfide
                Ethyl thioalcohol
                Ethyl sulfhydrate
    Molecular
      Formula:   C2H6S
    Structure:    CH3 - CH2  - SH
    Chemical Properties

       Molecular Weight:  62.13

       Vapor Pressure:  551.91 mm at 25C

       Boiling Point:   35Cat760mm

       Density:  0.83907 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
          Fire-dangerous
          Explosion-moderate
Physical State:  Liquid

Vapor Density:  2.14

Melting Point:   -144.4C

Solubility:   Slightly soluble (H2O)
                                            AII-314

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                                                                    Ethyl mercaptan
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
      LDSO

      LCSO
Non-lethal Acute Effects:
      CNS irritant
      TCLo
 682 mg/kg
 450 mg/kg
4420 ppm (4 hours)
2770 ppm
   4 ppm
Animal
rat
rat
rat
mouse
human
  Route
oral
intraperitoneal
inhalation
inhalation
inhalation
Chronic Toxicity
   U.S. Occupational Standard: (air) Ceiling level: 10 ppm
   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
                                       All-315

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Ethyl  methanesulfonate
                                     CHEMICAL  NAME
    CAS Number:

    Chemical Name:
62-50-0

Methanesulfonic acid, ethyl ester
    Synonyms:  Ethyl ester of methylsulfonic acid
               Methylsulfonic acid, ethyl ester

    Molecular
      Formula:  C3H8O3S
                      O
                      II
    Structure:   CH3 - S  - OCH2CH3
                      II   .
                      O



    Chemical Properties

       Molecular Weight:      124.17

       Vapor Pressure:

       Boiling Point:   159C

       Density:  1.187 at 25C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                              Physical State:  Liquid

                              Vapor Density:

                              Melting Point:  -37C

                              Solubility:   Very soluble (H2O)
                                            AII-316

-------
                                                        Ethyl  methanesulfonate
                              PRODUCTION DATA
Annual U.S.
 Production:

Fraction of
 Dispersion:
Release Rate (million Ibs/yr):
Not produced commercially
Consumption:

Fraction of Pro-
 duction Lost:
                                 TOXICITY DATA
Acute Toxicity
             Dosage
            200 mg/kg
 Animal
mouse
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
         TDLo
       Neoplasm
             36 mg/kg
                                 mouse
   Mutagenicity:
         TDLo

   Teratogenicity:
       TDLo
   Other Chronic Effects:
                          100 mg/kg
                          83 mg/kg
            300 mg/kg
            380 mg/kg


            200 mg/kg (13 days)
                                 rat
                                 mouse
 rat
 mouse
TLV:
 pregnant rat
  Route
intraperitoneal
                    parenteral
                    intraperitoneal
                    subcutaneous
 intraperitoneal
 intraperitoneal


 intraperitoneal
                                      AII-317

-------
N-Ethylmorpholine
                                    CHEMICAL NAME
    CAS Number:   100-74-3

    Chemical Name:    4-Ethylmorpholine

    Synonyms:  N-Ethylmorpholine
    Molecular
      Formula:  C6H13NO
                  CH2CH3
    Structure:
    Chemical Properties

       Molecular Weight:   115.2

       Vapor Pressure:

       Boiling Point:   138C

       Density:   0.8996 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:   Fire-moderate
Physical State:   Liquid

Vapor Density:  4.00

Melting Point:   -63C

Solubility:   Infinite (H2O)
                                           AII-318

-------
                                                               N-Ethylmorpholine
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
                                TOXICITY DATA
Acute Toxicity
     LD50
     LCLo
  Dosage
1780mg/kg
2000 ppm (4 hours)
Non-lethal Acute Effects:
     Irritant to mucous membranes, eyes
                         100 ppm
 Animal
rat
rat
                     human
  Route
oral
inhalation
                  inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 20 ppm (skin)



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV: 20 ppm (skin)
                                     AII-319

-------
Ethyl naphthalene
                                    CHEMICAL NAME
    CAS Number:   1127-76-0
    Chemical Name:   1-Ethyl naphthalene
    Synonyms:   Ethyl naphthalene
    Molecular
      Formula:   C12Hi2
                       CH2CH3
    Structure:
    Chemical Properties

       Molecular Weight:   156.23

       Vapor Pressure:  1 mm at 20.0C
       Boiling Point:   258C at 760 mm

       Density:   1.0082 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:  Liquid

Vapor Density:

Melting Point:   -13.88C

Solubility:    Insoluble (H2O)
                                          AII-320

-------
                                                              Ethyl naphthalene
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal             Route
                       5000mg/kg            rat               oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AII-321

-------
Ethyl  oxalate
                                      CHEMICAL  NAME
    CAS Number:   95-92-1

    Chemical Name:    Oxalic acid, diethyl ester

    Synonyms:  Ethyl oxalate            Oxalic ether
                Diethyl oxalate
                Diethyl ethaneioate
    Molecular
      Formula:  C6H10O4
                  O - CH2CH3
                  I         	
                  c  =  o
    Structure:     I
                  C  =  O
                  I
                  O - CH2CH3


    Chemical Properties

       Molecular Weight:   146.14                      Physical State:  Liquid

       Vapor Pressure:  1 mm at 47.4C                  Vapor Density:  5.04
       Boiling Point:   185.7Cat 760mm               Melting Point:   -38.5C
        Density:   1.0785 at 20C/4C                    Solubility:   Slightly (hot H2O)

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fire-moderate
                   Disaster hazardmoderate-toxic fumes
                                             All-322

-------
                                                                        Ethyl oxalate
                               PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
      LD50                400mg/kg            rat                 oral

Non-lethal Acute Effects:             	
      Local irritant
      Ingestion causes severe damage to kidneys
      Caustic effect on mouth, esophogus, and stomach
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               tLV:

   Other Chronic Effects:
                                      AII-323

-------
Ethyl  parathion
                                     CHEMICAL NAME


    CAS Number:   25737-28-4

    Chemical Name:    Phosphorothioic acid, O,O-diethyl-O-(p-nitrophenol) ester
    Synonyms:
             Ethyl parathion
             6,O-Diethyl O-p-nitrophenyl thiophosphate
             Alkron
             Compound 3422
             Penphos
             Vapophor
                   C,0H14N03PS

                   NO.
Molecular
  Formula:

Structure:
                   O - P - (OC2H5)2

    Chemical Properties

       Molecular Weight:  291.3

       Vapor Pressure:

       Boiling Point:

       Density:  1.26 at 25C/4C

       Octanol/Water Parti-
         tion Coefficient:  2.15

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                                Physical State:  Liquid

                                                Vapor Density:

                                                Melting Point:   375C
                                                Solubility:    Slightly soluble (H2O)
                                            AII-324

-------
                                                                       Ethyl  parathion
                                PRODUCTION DATA
Annual U.S.
 Production:   15 x 106 Ibs.

Fraction of
 Dispersion:    1 -0

Release Rate (million Ibs/yr):  15.2
                                             Consumption:   15.0 x 106 Ibs.

                                             Fraction of Pro-
                                              duction Lost:  0.01
Acute Toxicity
      LD50
      LD
         Lo
Chronic Toxicity
                               TOXICITY DATA

                         Dosage                Animal
                          2 mg/kg             rat
                          7 mg/kg             rat
                       1500 mg/kg             rat
                          6 mg/kg             mouse
                         40 mg/kg             rabbit
                        600 mg/kg             guinea pig
                          3 mg/kg             pigeon
                          6 mg/kg             quail
                       2340 mg/kg             duck
                          6 mg/kg             mammal
                          2 mg/kg             wild bird
                         10 mg/m3 (2 hours)    rat
                         50 mg/m3 (2 hours)    rabbit
                         14 mg/m  (2 hours)    guinea pig
                        240 mg/kg             human
                          3 mg/kg             rat
                         30 mg/kg             mouse
  Route
oral
skin
intraperitoneal
oral
skin
skin
oral
oral
oral
unreported
roal
inhalation
inhalation
inhalation
oral
intravenous
subcutaneous
   U.S. Occupational Standard:  (air) TWA 110 Mg/m3 (skin)
       Farm worker field reentry standard
   Carcinogenicity:
Mutagenicity:

Teratogenicity:

Other Chronic Effects:
                                                TLV:
                                        AII-325

-------
Ethyl silicate
                                     CHEMICAL  NAME
    CAS Number:   78-10-4

    Chemical Name:    Silicic acid, tetraethyl ester

    Synonyms:   Ethyl silicate
                Tetraethyl-o- silicate
    Molecular
      Formula:
                            OCH2
                             I   _
    Structure:   CH3CH2O - Si-OCH2CH3
                            I
                            ocH2CH3



    Chemical Properties

       Molecular Weight:   208.30

       Vapor Pressure:  1 mm at 20C
       Boiling Point:   168.8 C at 760 mm

       Density:  -933 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:  Fire-moderate
Physical State:  Liquid

Vapor Density:
Melting Point:    -82.5C

Solubility:  Soluble, decomposes (HjO)
                                             AII-326

-------
                                                                          Ethyl  silicate
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                                               Consumption:

                                               Fraction of Pro-
                                                 duction Lost:
                                  TOXICITY DATA
Acute Toxicity
  Dosage
1000mg/kg
1000 ppm (4 hours)
1060 ppm (4 hours)
 700 ppm (6 hours)
Non-lethal Acute Effects:
     Irritant to eyes and upper respiratory tract
     Nephritis
     Liver injury
     Anemia
     Leucocytosis
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppm


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:               .

   Other Chronic Effects:
                                                Animal
                                               rat
                                               rat
                                               rat
                                               guinea pig
                                                                     Route
                                                                   oral
                                                                   inhalation
                                                                   inhalation
                                                                   inhalation
                                               TLV: 100 ppm
                                       'AII-327

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                                   TECHNICAL REPORT DATA
                            (Please read Instructions on the reverse before completing)
1. REPORT NO.
 EPA-450/3-77-008C
                              2.
                                                            3. RECIPIENT'S ACCESSION NO.
4. TITLEjAND SU
      mfn'ary Scoring of Organic Air Pollutants:
Chemistry,  Production and  Toxicity of Selected
Synthetic  Organic Chemicals
            n-F) Appendix  II	
5. REPORT DATE
        October  1976
                                                            6. PERFORMING ORGANIZATION. CODE
7. AUTrtOR(S
                                                            8. PERFORMING ORGANIZATION REPORT NO.
     J. Dorigan,  B.  Fuller, R.  Duffy
9. PERFORMING ORGANIZATION NAME AND ADDRESS
     The Mitre  Corporation
     Metrek  Division
     Westgate Research Park
     McLean, Virginia  22101
                                                            10. PROGRAM ELEMENT NO.
                                                       11. CONTRACT/GRANT NO.
                                                              68-02-1495
12. SPONSORING AGENCY NAME AND ADDRESS
                                                             13. TYPE OF REPORT AND PERIOD COVERED
     EPA, Office of Air Quality Planning and  Standards
     Strategies  and Air Standards Division
     Research  Triangle Park,  N.C.  27711
                                                        14. SPONSORING AGENCY CODE
15. SUPPLEMENTARY NOTES
16. ABSTRACT
           This is the second  of a series  of four appendices  to the report  "Scoring
     of Organic Air Pollutants."  The entire appendix contains a compilation of
     available data on chemical structure and properties,  environmental  persistence,
     production, and toxicity for 637 synthetic organic  chemicals.
17.
                                KEY WORDS AND DOCUMENT ANALYSIS
                  DESCRIPTORS
                                          b.lDENTIFIERS/OPEN ENDED TERMS  C. COSATI Field/Group
     organic chemical  structure
     organic chemical  properties
     organic chemical  production
     organic chemical  toxicity
18. DISTRIBUTION STATEMENT
                                               19. SECURITY CLASS (ThisReport)
                                                 unclassified
                                                                      21. NO. OF PAGES
                                                                              344
     unlimited
                                          20. SECURITY CLASS (Thispage)
                                            unclassified
                                                                           22. PRICE
EPA Form 2220-1 (9-73)

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