EPA-450/3-77-008d
October 1976
PRELIMINARY SCORING
OF SELECTED ORGANIC
AIR POLLUTANTS
APPENDIX III -
CHEMISTRY, PRODUCTION,
AND TOXICITY
OF CHEMICALS
F THROUGH N
U.S. ENVIRONMENTAL PROTECTION AGENCY
Office of Air and Waste Management
Office of Air Quality Planning and Standards
Research Triangle Park, North Carolina 27711
-------
EPA-450/3-77-008d
PRELIMINARY SCORING
OF SELECTED ORGANIC AIR POLLUTANTS
APPENDIX III -
CHEMISTRY, PRODUCTION,
AND TOXICITY
OF CHEMICALS
FTHROUGHN
by
J. Dorigan, B. Fuller and R. Duffy
The Mitre Corporation
Metrek Division
Westgate Research Park
McLean, Virginia 22101
Contract No. 68-02-1495
Project No. 077L
EPA Project Officer: David R. Patrick
Prepared for
ENVIRONMENTAL PROTECTION AGENCY
Office of Air and Waste Management
Office of Air Quality Planning and Standards
Research Triangle Park, North Carolina 27711
October 1976
-------
PREFACE
A program is being developed by the Emission Standards and
Engineering Division of the U.S. Environmental Protection Agency to
determine the extent and environmental effects of atmospheric industrial
emissions of synthetic organic chemicals. As part of the initial effort,
EPA requested that the MITRE Corporation, METREK Division, devise a
system for identifying those chemicals that may be released to the
atmosphere from chemical manufacturing plants and whose health effects
have been documented. To address this need, three general categories of
information for each compound to be evaluated were deemed directly
relevant:
(1) the quantity of the compound produced;
(.2) the potential for atmospheric release from chemical manu-
facturing plants, and
C3) the toxicological effects of the compounds.
The results of this study are presented in the accompanying report
"Preliminary Scoring of Organic Air Pollutants."
The following dossiers were prepared for each of the 637 compounds
under consideration in an attempt to collate the pertinent data for
subsequent evaluation.
-------
TABLE OF CONTENTS
Ferbam
Ferrocene
Fluometuron
Folex
Folpet
Formaldehyde
Fo rmamide
Formic acid
Fumaric acid
Furfural
Furfuryl alcohol
Glycerol
Glycerol monostearate
Glycidol
Glycine
Glyoxal
Guanidine
Guthion
Heptachlor
Heptene
Herban
Hexachloroethane
Hexachloronaphthalene
Hexalene glycol
Hexamethylenetetramine
Hexanediamine
Hydrogen, cyanide
Hydroquihone
Indene
Isoamyl alcohol
Isobutyl acetate
Isobutyl alcohol
Isobutylaldehyde
Isobutylene
Isobutyric acid
Isodecyl alcohol
Isooctyl alcohol
Isooctylphenol, ethoxylated
Isophorone
Isophthalic acid
Isoprene
Isopropyl acetate
Isopropyl alcohol
Isopropylamine
AIII-2
AIII-4
AIII-6
AIII-8
AIII-10
AIII-12
AIII-14
AIII-16
AIII-18
All1-20
AIII-22
AIII-24
All1-26
AIII-28
AIII-30
AIII-32
AIII-34
AIII-36
AIII-38
AIII-40
AIII-42
AIII-44
AIII-46
AIII-48
AIII-50
AIII-52
AIII-54
AIII-56
AIII-58
AIII-60
AIII-62
AIII-64
AIII-66
AIII-68
AIII-70
AIII-72
AIII-74
AIII-76
AIII-78
AIII-80
AIII-82
AIII-84
AIII-86
AIII-88
ill
-------
TABLE OF CONTENTS (Continued)
Isopropy1 chloride
Isopropyl ether
o-Isopropylphenol
p-Isopropylphenol
Ketene
Ligninsulfonic acid,
Ligninsulfonic acid,
Ligninsulfonic acid,
Ligninsulfonic acid,
Lindane
Linuron
Magenta
Malathion
Maleic acid
Maleic anhydride
Maleic hydrazide
Malic acid
Melamine
Mesitylene
Mesityl oxide
Methacrylic acid
Methacrylonitrile
Methallyl alcohol
Methallyl chloride
Methane
Methanearsonic acid
Methomyl
Methoxychlor
Methoxyethano1
Methyl acetate
Methyl acetoacetate
Methylal
Methyl alcohol
Methylamine
Methylamyl acetate
Methylamyl alcohol
Methylaniline
Methylbenzyl alcohol
Methyl bromide
Methyl butyl ketone
Methylbutynol
Methyl cellulose
Methyl chloride
Methylcholanthrene
ammonium salt
calcium salt
ferrochrome salt
sodium salt
AI11-90
AIII-92
AIII-94
AIII-96
AIII-98
AIII-100
AIII-102
AIII-104
AIII-106
AIII-108
AIII-110
AIII-112
AIII-114
AIII-116
AIII-118
AIII-120
AIII-122
AIII-124
AIII-126
AIII-128
AIII-130
AIII-132
AIII-134
AIII-136
AIII-138
AIII-140
AIII-142
AIII-144
AI 11-146
AIII-148
AIII-150
AIII-152
AIII-154
AIII-156
AIII-158
AIII-160
AIII-162
AIII-164
AIII-166
AIII-168
AIII-170
All1-172
AIII-174
AIII-176
IV
-------
TABLE OF CONTENTS (Continued)
Methylcyclohexane
Methylcyclohexanol
Methylcyclohexanone
4,4'-Methylenebis (2-chloroaniline)
Methylene chloride
Methylenedianiline
Me thyIdioxolane
Methyl ethyl ketone
Methyl formate
Methylhydrazine
Methyl iodide
Methyl isoamyl ketone
Methyl isobutyl ketone
Methyl isocyanate
Methyl mercaptan
Methyl methacrylate
Methylnaphthalene
N-Methyl-N'-nitro-N-nitrosoguaindine
Methyl parathion
Methylpentanediol
Methylpentynol
Methylphenylcarbinol
a-Methylstyrene
Mevinphos
Mirex
Monosodium glutamate
Morpholine
MSMA
Nab am
Naled
Naphtha (solvent)
Naphthalene
a-Naphthalenesulfonic acid
3-Naphthalenesulfonic acid
a-Naphthol
B-Naphthol
1-Naphthylamine
2-Naphthylamine
Naptalam
Neopentanoic acid
Nitrilotriacetic acid, trisodium salt
p-Nitroaniline
Nitroanisole
Nitrobenzene
AIII-178
AIII-180
AIII-182
AIII-184
AIII-186
AIII-188
AIII-190
AllI-192
AIII-194
AIII-196
AIII-198
AIII-200
AIII-202
AIII-204
AIII-206
AIII-208
AIII-210
AIII-212
AIII-214
A1II-216
AIII-218
AIII-220
AIII-222
A1II-224
AIII-226
AI11-228
AIII-230
AIII-232
AIII-234
AIII-236
AIII-238
AIII-240
AIII-242
AHI-244
AIII-246
A1II-248
AIII-250
AIII-252
AIII-254
AIII-256
AIII-258
AIII-260
A1II-262
A1II-264
v
-------
TABLE OF CONTENTS (Continued)
p-Nitrobenzoic acid
Nitrocellulose
Nitroethane
Nitroglycerine
Nitromethane
m-Ni trophenol
o-Nitrophenol
p-Nitrophenol
1-Nitropropane
2-Nitropropane
N-Nitrosodiethylamine
N-Nitrosodimethylamine
Nitrosoethylurea
Nitrosomethylurea
m-Nitrotoluene
o-Nitrotoluene
p-Nitrotoluene
Nonene
Nonyl phenol
Page
AIII-266
AIII-268
AIII-270
AI11-272
AIII-274
AIII-276
AIII-278
AllI-2 80
AIII-282
AIII-284
AIII-286
AIII-288
AIII-290
AIII-292
AIII-294
All I-2 96
AIII-298
AIII-300
AIII-302
vi
-------
APPENDIX III
CHEMISTRY, PRODUCTION AND TOXICITY OF SELECTED
SYNTHETIC ORGANIC CHEMICALS
AIII-1
-------
Ferbam
CHEMICAL NAME
CAS Number: 301-05-3
Chemical Name: Ferbam
Synonyms: Dimethyldithiocarbamic acid
Ferric dimethyl dithiocarbamate
Tris (dimethyldithiocarbamato) iron
Molecular
Formula: C9H18FeN3S6
Structure:
CH,
CH,
N-C-S
Chemical Properties
Molecular Weight: 416.5
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Fe
Physical State: Solid
Vapor Density:
Melting Point: Decomposes > 180°C
Solubility: Slightly (H2O)
Safety Hazard:
. All1-2
-------
Ferbam
PRODUCTION DATA
Annual U.S.
Production: 2.3 x 106 Ibs. (1967)
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Consumption:
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity Dosage Animal
LDSO 4000 mg/kg rat
2700 mg/kg rat
LDLo 63 mg/kg mouse
2000 mg/kg rabbit
200 mg/kg rabbit
450 mg/kg guinea pig
700 mg/kg guinea pig
Non-lethal Acute Effects:
Irritant to eyes and mucous membranes
Route
oral
intrapeiitoneal
intraperitoneal
oral
intraperitoneal
oral
intraperitoneal
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 15 mg/m3
Carcinogenicity: Recognized carcinogen
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 15 mg/m3
AIII-3
-------
Ferrocene
CHEMICAL NAME
CAS Number: 102-54-5
Chemical Name: Ferrocene
Synonyms: Dicyclopentadiene iron
Molecular
Formula: Ci0H10Fe
Structure:
Fe
Chemical Properties
Molecular Weight: 186.0
Vapor Pressure:
Boiling Point: Sublimes
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Resistant to ultraviolet light
Physical State: Solid
Vapor Density:
Melting Point: 173 to 174°C
Solubility: Insoluble (H2O)
Safety Hazard: Fire-moderate
Disaster hazard-dangerous—toxic fumes
All1-4
-------
Ferrocene
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 1320mg/kg rat oral
500mg/kg rat intraperitoneal
1550mg/kg mouse oral
335 mg/kg mouse intraperitoneal
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-5
-------
Fluometuron
CHEMICAL NAME
CAS Number: 2164-17-2
Chemical Name: l,l-Dimethyl-3-(a,a,a-trifluoro-m-tolyl) urea
Synonyms: Fluometuron
Molecular
Formula:
Structure:
CF,
O
CH,
CH,
Chemical Properties
Molecular Weight: 232.23
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 163 to 164.5°C
Solubility: 90ppm(H2O)
Safety Hazard:
AIII-6
-------
Fluometuron
Annual U.S.
Production: 4 x 106 Ibs. (1971)
PRODUCTION DATA
Consumption:
Fraction of
Dispersion:
1.0
Fraction of Pro-
duction Lost: 0.015
Release Rate (million Ibs/yr): 4
Acute Toxicity
LDSO
Dosage
89 mg/kg
900 mg/kg.
TOXICITY DATA
Animal
rat
mouse
Non-lethal Acute Effects:
Emesis
Coma
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Depression
Route
oral
oral
TLV:
AIII-7
-------
Folex
CHEMICAL NAME
CAS Number: 150-50-5
Chemical Name: Phosphorotrithious acid, tributyl ester
Synonyms: Folex
S,S,S-Tributyl phosphorotiithioite
Molecular
Formula: Ci2H27PS3
CH3(CH2)3-S ^
Structure: , P - S (CH,) CH,
CH3(CH2)3-S 2 3
Chemical Properties
Molecular Weight: 298.54
Vapor Pressure:
Boiling Point: 115 to 134°Cat0.08mm
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility: Insoluble (H2O)
Safety Hazard:
AllI-8
-------
Folex
PRODUCTION DATA
Annual U.S.
Production:—3 x 106 Ibs. (1971) Consumption:
Fraction of Fraction of Pro-
Dispersion: 1-0 duction Lost: 0.015
Release Rats (million Ibs/yr): 3
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 910mg/kg rat oral
615 mg/kg rat skin
76 mg/kg rat intraperitoneal
350 mg/kg rat unreported
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-9
-------
Folpet
CHEMICAL NAME
CAS Number: 133-07-3
Chemical Name: Phthalimide-N[(trichloromethyl)thio]
Synonyms: Folpet
Phaltan
Molecular
Formula: C9H4Cl3NO2S
Structure:
Chemical Properties
Molecular Weight: 296.6 Physical State: Solid
Vapor Pressure: Vapor Density:
Boiling Point: Melting Point: 177°C
Density: Solubility: Nearly insoluble (H26)
Octanol/Water Parti-
tion Coefficient: 2.85
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Disaster hazard-dangerous—emits highly toxic fumes of SOX and NOX
AllI-10
-------
Folpet
Annual U.S.
Production: 2 x 106 Ibs. (1971)
Fraction of
Dispersion: Estimated at 1.0
Release Rate (million Ibs/yr): 2.0
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LDjo
Non-lethal Acute Effects:
TDLo
TQXICITY DATA
lO.OOOmg/kg
Animal
rat
500 mg/kg (7 days) pregnant hamster
Route
oral
oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: Teratogenic
Other Chronic Effects:
TLV:
AllI-11
-------
Formaldehyde
CHEMICAL NAME
CAS Number: 50-00-0
Chemical Name: Formaldehyde (Commercial solutions 37%-50%)
Synonyms: Methanal
Methyl aldehyde
Formalin
Molecular
Formula: CH2O
O
II
Structure: H - C - H
Chemical Properties
Molecular Weight: 30.03 Physical State: Gas or Liquid
Vapor Pressure: 1946.67 mm at 25°C Vapor Density:
Boiling Point: -21°Cat760mm Melting Point: -92°C
Density: 0.815 at 20°C/4°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient: -0.96
Environmental Persistence
BOD: 30% of theoretical after 5 days at 20°C at 10 mg/ml
Total theoretical oxygen demand -1.1 gm/gm
Atmospheric Reactivity:
Activity toward 03: No data
RO2: 1%= 10 days
OH: tM= 1.2 hours
Safety Hazard: Fire-moderate
Explosion-moderate
AIII-12
-------
Formaldehyde
PRODUCTION DATA
Annual U.S.
Production: 5651.8 x 106 Ibs.
Fraction of
Dispersion: 0.01
Release Rate (million Ibs/yr): 52.7
Consumption: 5622.8 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
LDLo
LCLo
Non-lethal Acute Effects:
Irritant
TCLo
Conjunctivitis
Dermatitis
Dosage
420 mg/kg
300 mg/kg
260 mg/kg
16 mg/kg
36 mg/kg
550 mg/kg
240 mg/kg
Animal
rat
mouse
guinea pig
mouse
human
dog
rabbit
Route
subcutaneous
subcutaneous
oral
intraperitoneal
oral
subcutaneous
subcutaneous
900 mg/kg (2 hours) mouse
820 mg/kg (8 hours) cat
inhalation
inhalation
13.8 ppm
human
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) "TWA 3 ppm
Ceiling limit 5 ppm
Peak exposure 10 ppm (30 minutes once in 8 hours)
Carcinogenicity:
Spindle cell sarcomas
Neoplastic effects
TDLo
Mutagenicity:
Teratogenicity:
rats
1300 mg/kg (65 weeks) rat
injections
subcutaneous
TLV:
3 ppm
Other Chronic Effects:
Irritates eyes, respiratory tract and skin as low as 0.3 ppm
AIII-13
-------
Forma mide
CHEMICAL NAME
CAS Number: 75-12-7
Chemical Name: Formamide
Synonyms: Methaneamide
Molecular
Formula: CH3NO
O
II
Structure: H - C - NH2
Chemical Properties
Molecular Weight: 45.04
Vapor Pressure: 1 mm at 70.5°C
Physical State: Liquid
Vapor Density:
Boiling Point: 210.7°C (decomposes starting at Melting Point: 2.55°C
about 180°C)
Density: 1.134 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: -1-67
Environmental Persistence
BOD:
Atmospheric Reactivity:
Solubility: Infinite (H2O)
Safety Hazard: Fire-moderate
Disaster hazard-moderate-toxic fumes
AllI-14
-------
For mam id e
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSo 2539mg/kg guinea pig intramuscular
Non-lethal Acute Effects:
Local irritant
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 20 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
TDL0 6 gm/kg pregnant rat intraperitoneal
Other Chronic Effects:
AIII-15
-------
Formic acid
CHEMICAL NAME
CAS Number: 64-18-6
Chemical Name: Formic acid
Synonyms: Methanoic acid
Hydrogen carboxylic acid
Molecular
Formula: CH2O2
O
II
Structure: H - C - OH
Chemical Properties
Molecular Weight: 46.3 Physical State: Liquid
Vapor Pressure: 42.38 mm at 25°C Vapor Density: 1.59
Boiling Point: 100.8°C Melting Point: 8.3°C
Density: 1.2201 at 20°C/4°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient: -0.73
Environmental Persistence
BOD: 68% of theoretical after 20 days at 20°C at 10 mg/ml
Total theoretical oxygen demand = 0.35 gm/gm
Atmospheric Reactivity:
Safety Hazard: Fire-moderate
AI11-16
-------
Formic acid
PRODUCTION DATA
Annual U.S.
Production: 46.9 x 106 Ibs.
Fraction of
Dispersion: 0.50
Release Rate (million Ibs/yr): 24.1
Consumption: 46.9 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LDSO
Dosage
1210mg/kg
llOOmg/kg
145 mg/kg
Animal
rat
mouse
mouse
Route
oral
oral
intravenous
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 5ppm
Moderate effects as an irritant or upon inhalation
Severe effects following ingestion
Nausea-15 ppm
AIII-17
-------
Fumaric acid
CHEMICAL NAME
CAS Number: 110-17-8
Chemical Name: Fumaric acid
Synonyms: trans-Butenedioic acid
Boletic acid
Lichenic acid
Molecular
Formula: C4H4O4
Allomaleic acid
O
Structure:
H
C~=C
J_
H
O
OH
Chemical Properties
Molecular Weight: 116.1
Vapor Pressure:
Boiling Point: 165°C at 1.7 mm (sublimes)
Density: 1.635 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 0.56
Environmental Persistence
BOD: 82% of theoretical at 20° after 10 days
Total theoretical oxygen demand = 0.83 gm/gm
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 287°C
Solubility: Slightly (H2O)
Safety Hazard: Fire-slight
AIII-18
-------
Fumaric acid
PRODUCTION DATAj
t
Annual U.S.
Production: 42 x 106 Ibs. (1974) Consumption: 42 x 10b Ibs.
Fraction of ' Fraction of Pro-
"'Dispersion: 0.30 duction Lost: 0.015
Release Rate (million Ibs/yr): 16.2
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AllI-19
-------
Furfural
CHEMICAL NAME
CAS Number: 98-01-1
Chemical Name: 2-Furaldehyde
Synonyms:. 2-Futancaibonal
Furfural
Fural
Molecular
Formula: CsH4O2
Furale
Structure:
\\
o
Chemical Properties
Molecular Weight: 96.1
Vapor Pressure: 2.08mmat25°C
Boiling Point: 161.7°Cat 764mm
Density: 1.161 at 20°C/20°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence.
BOD:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density: 3.31
Melting Point: -38.7°C
Solubility: Slightly (H2O)
Safety Hazard: Fire-moderate
Explosion—moderate
AIII-20
-------
Furfural
PRODUCTION DATA
Annual U.S.
Production: 149.6 x 106 Ibs. (1974)
Fraction of
Dispersion: 0.01
Release Rate (million Ibs/yr):
Consumption: 153 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LD50
LCLo
TOXICITY DATA
Dosage
127 mg/kg
425 mg/kg
2300 mg/kg
928 mg/kg
541 mg/kg
153 ppm (4 hours)
Animal
rat
mouse
dog
rabbit
guinea pig
rat
Route
oral
oral
oral
oral
oral
inhalation
Non-lethal Acute Effects:
Irritation to eyes, nose and throat
TD
Lo
600 gm/nr (eye)
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 5 ppm (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-21
-------
FurfuryI alcohol
CHEMICAL NAME
CAS Number: 98-00-0
Chemical Name: Furfury 1 alcohol
Synonyms: 2-Furyl carbinol
(2-Furyl) methanol
Molecular
Formula: CSH6O2
Structure:
CH2OH
Chemical Properties
Molecular Weight: 98.1
Vapor Pressure: 1 mm at 31.8°C
Boiling Point: 171°C at 750mm
Density: 1.129 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard: Fire-moderate
Explosion-moderate
Physical State: Liquid
Vapor Density: 3.37
Melting Point:
Solubility: Infinite (H2O)
AllI-22
-------
Furf uryl alcohol
PRODUCTION DATA
Annual U.S.
Production: Estimated as 70 x 106 Ibs. (1974) Consumption: 4 x 106 Ibs. (1964)
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
Dosage
275 mg/kg
40 mg/kg
650 mg/kg
233 ppm (4 hours)
Non-lethal Acute Effects:
Irritation to eyes
Nausea
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 50 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
mouse
rabbit
rat
TLV: 50 ppm
Route
oral
oral
intravenous
inhalation
AIII-23
-------
Glycerol
CAS Number: 56-81-5
Chemical Name: Glycerol
Synonyms: 1,2,3-Propane triol
Glycerin
Glycyl alcohol
Molecular
Formula: C3H8O3
CHEMICAL NAME
Structure:
CH2 - OH
CH-OH
I
CH2 - OH
Chemical Properties
Molecular Weight: 92.09
Vapor Pressure: 4.99 x 10"4 at 25°C
Boiling Point: 290°C (decomposes)
Density: 1-2653 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: -2.66
Environmental Persistence
BOD: 74% of theoretical for 10 days at 2 mg/1
Total theoretical oxygen demand = 1.37 gm/gm
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-dangerous
Physical State: Liquid
Vapor Density: 3.17
Melting Point: 20°C
Solubility: Soluble (H2O)
AI11-24
-------
Glycerol
PRODUCTION DATA
Annual U.S.
Production: 199.2 x 106 Ibs. Consumption: 144.1 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 0.60 duction Lost: 0.015
Release Rate (million Ibs/yr): 89.4
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 7750mg/kg guinea pig oral
Non-lethal Acute Effects:
Irritant to eyes and respiratory tract
Nausea and vomiting
Convulsions and paralysis
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-25
-------
Glycerol monostearate
CHEMICAL NAME
CAS Number: 1319-95-5
Chemical Name: Monosteaiin
Synonyms: Glyceryl monostearate
Glycerol monostearate
CMS
Molecular
Formula: C2iH42O4
CH2OH
Structure: CH OH
I
CH2O - C - (CH2)16 CH3
O
Chemical Properties
Molecular Weight: 358.63 Physical State: Solid
Vapor Pressure: Vapor Density:
Boiling Point: 58to59°C Melting Point: 74°C
Density: 0.97 Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence.
BOD:
Atmospheric Reactivity:
Safety Hazard:
AllI-26
-------
Glycerol monostearate
PRODUCTION DATA
Annual U.S.
Production: 27.2 x 106 Ibs. Consumption: 27.2 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 1-0 duction Lost: 0.03
Release Rate (million Ibs/yr): 28.0
TOXICITY DATA
Acute Toxicity Dosage Animal Route
200 mg/kg mouse intraperitoneal
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-27
-------
Glycidol
CHEMICAL NAME
CAS Number: 556-52-5
Chemical Name: 2,3 - Epoxy - 1 - propanol
Synonyms: Glycide
Glycidol
Molecular
Formula: C3H6O2
O
/ \
Structure: H - c - C - OH
]_ \
H H
Chemical Properties
Molecular Weight: 74.09 Physical State: Liquid
Vapor Pressure: Vapor Density:
Boiling Point: 167°C (decomposes) Melting Point:
/
Density: 1.165 at 0°C/4°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AI11-28
-------
Glycidol
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LC50
850 mg/kg
450 mg/kg
1980 mg/kg
580 ppm (8 hours)
450 ppm (4 hours)
Non-lethal Acute Effects:
Nervous excitation followed by depression
Irritant to eyes and respiratory tract
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 50 ppm
Carcinogenicity:
Animal
rat
mouse
rabbit
rat
mouse
Route
oral
oral
skin
inhalation
inhalation
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 50ppm
AIII-29
-------
Glycine
CAS Number: 56-40-6
Chemical Name: Glycine
Synonyms: Aminoacetic acid
Glycocoll
Molecular
Formula: C2HSN02
CHEMICAL NAME
Structure: H2N - CH2 - C
O
OH
Chemical Properties
Molecular Weight: 75.07
Vapor Pressure:
Boiling Point: (decomposes)
Density: 1.1607
Octanol/Water Parti-
tion Coefficient: -3.03
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 232 to 236°C (decomposes)
Solubility: Soluble (H2O)
Safety Hazard:
AllI-30
-------
Glycine
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: . duction Lost:
Release Rate (million Ibs/yr):
TOXICITYDATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogehicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-31
-------
Glyoxal
CHEMICAL NAME
CAS Number: 107-22-2
Chemical Name: Glyoxal
Synonyms: Ethanedial
Oxalaldehyde
Biformyl
Molecular
Formula:
Structure:
O
O
\\
C - C
H
Chemical Properties
Molecular Weight: 58.02
Vapor Pressure: <10 mm at 25°C
Boiling Point: 50.4°C
Density: 1-26 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Physical State: Solid or Liquid
Vapor Density:
Melting Point: 15°C
Solubility: Very soluble (H2O)
Safety Hazard: Fire-slight
. AIII-32
-------
Glyoxal
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDso 200 mg/kg mouse intraperitoneal
760 mg/kg guinea pig oral
100 mg/kg rat oral
Non-lethal Acute Effects:
Local irritant to skin and mucous membranes
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-33
-------
Guanidine
CHEMICAL NAME
CAS Number: 113-00-8
Chemical Name: Guanidine
Synonyms: Amino methanamidine
Carbamamidine
Molecular
Formula: CHSN3
Structure:
NH
II
C
H2N NH2
Chemical Properties
Molecular Weight: 59.07
Vapor Pressure:
Boiling Point: 160°C (decomposes)
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Solid
Vapor Density:
Melting Point: ca. 50°C
Solubility: Very soluble (H2O)
AIII-34
-------
Guanidine
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
175 mg/kg rat intraperitoneal
300 mg/kg mouse subcutaneous
200 mg/kg . dog. subcutaneous
100 mg/kg cat intraperitoneal
200 mg/kg cat subcutaneous
5 00 mg/kg rabbit oral
500 mg/kg rabbit subcutaneous
1500 mg/kg guinea pig intraperitoneal
100 mg/kg guinea pig subcutaneous
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-35
-------
Guthion
CHEMICAL NAME
CAS Number: 86-50-0
Chemical Name: Phosphorodithioic acid, O-O, dimethyl ester, S-ester with 3-(mercaptomethyl)-l,2,3-
benzotriazin-4(3H)-one
Synonyms: Guthion
O-O-Dimethyl-S-(4-oxo-l,2,3-benzotriazin-3-(4H)-ylmethyl)-phosphorodithioate
Benzotiiazinedithiophosphoric acid, dimethyoxy ester
N-Methylbenzamide, dimethyldiphosphoric acid ester
Molecular \
Formula: Ci0Hj2N3O3PS2
o
II
s ^
Structure: uc,O - P - S - CH, - N
' H '
2 5 N _
Chemical Properties
Molecular Weight: 317.34
Vapor Pressure:
Boiling Point: Decomposes at elevated
temperatures
Density: 1.44 "
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 74°C
Solubility: Slightly (H2O)
(29 ppm at 25 °C)
Safety Hazard:
AIII-36
-------
Guthion
Annual U.S.
Production:
Fraction of
Dispersion:
4.0 x 10° Ibs.
1.0
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
0.015
Release Rate (million Ibs/yr): 4.0
Acute Toxicity
LDSO
16 mg/kg
300 mg/kg
15 mg/kg
4 mg/kg
80 mg/kg
277 mg/kg
8 mg/kg
5 mg/kg
TOXICITY DATA
Animal
rat
rat
lat
mouse
guinea pig
chicken
wild bird
mouse
Route
oral
skin
unreported
intraperitoneal
oral
oral
oral
oral
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 200 Mg/m3 (skin)
EPA-Farm worker field reentry standard
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects: Cholinesterase inhibition
AIII-37
-------
Heptachlor
CHEMICAL NAME
CAS Number: 76-44-8
Chemical Name: M.S.ej.S'.S-Heptachloro-SMJJa-
tetrahydro-4,7-methanoindene
Synonyms: Heptachlor
3,4,5,6,7,8,9-Heptachlorodicyclopentadiene
Molecular
Formula: C HCl-
Structure:
Cl
Cl Cl
Chemical Properties
Molecular Weight: 373.32
Vapor Pressure:
Boiling Point:
Density: 1.57 to 1.59
Octanol/Water Parti-
tion Coefficient: 5.05
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 95 to 96°C
Solubility: Insoluble (H2O)
Safety Hazard: Disaster hazard-dangerous, decomposition to toxic fumes
AllI-38
-------
Heptachlor
PRODUCTION DATA
Annual U.S.
Production:
Fraction of
Dispersion:
6 x 106 Ibs.
1.0
Consumption:
Fraction of Pro-
duction Lost: 0.01
Release Rate (million Ibs/yr): 6.0
TOXICITY DATA
Acute Toxicity
LDSO
Non-lethal Acute Effects:
Convulsions
Kidney damage
Dosage
40 mg/kg
195 mg/kg
27 mg/kg
2000 mg/kg
116 mg/kg
62 mg/kg
25 mg/kg
40 mg/kg
Animal
rat
rat
rat
rabbit
guinea pig
chicken
mouse
mouse
Route
oral
skin
intraperitoneal
skin
oral
oral
oral
intravenous
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 500 Mg/m3 (skin)
Carcinogenicity:
Potential carcinogen according to EPA
Mutagenicity:
Teratogenicity: f LV: 0.5 mg/m3
Other Chronic Effects:
AllI-39
-------
Heptene
CHEMICAL NAME
CAS Number: cis: 7642-10-6
trans: 14686-14-7
Chemical Name: cis: (Z)-3-Heptene
trans: (E)-S-Heptene
Synonyms: l-Ethyl-2-propyl ethylene
3-Heptene
3-Heptylene
Molecular
Formula: C?H14
Structure:
CH3
CH
cis
CH3
CH,
H
rvt
CH2
C = C
CH,
CHh
H
trans
Chemical Properties
Molecular Weight: 98.18
Vapor Pressure: 48.24 mm at 25°C
Boiling Point: 96°C at 760 mm (cis)
95.67°C at 760 mm (trans)
Density: 0.7030 at 20°C/4°C (cis)
0.6981 at 20°C/4°C (trans)
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 3.38
Melting Point: -136.63°C (trans)
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts vigorously with oxidizing materials
Safety Hazard: Fire-dangerous
AIII-40
-------
Heptene
PRODUCTION DATA
Annual U.S.
Production: 114xl06lbs. Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Potential carcinogen according to EPA (unspecified isomer)
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects: Minor irritant
Minor effects upon ingestion or inhalation
AI11-41
-------
Herban
CHEMICAL NAME
CAS Number: 2163-79-3
Chemical Name: 3-(Hexahydro-4,7-methanoindah-5-yl)-l,l-dimethylurea
Synonyms: Heiban
Norea
Molecular
Formula:
Structure:
Chemical Properties
Molecular Weight: 222.3
Vapor Pressure: Insignificant
Boiling Point: Decomposes
Density: 1.162 at 25°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 168 to 169°C
Solubility: Very slightly soluble (H2O)
Safety Hazard:
AIII-42
-------
Annual U.S.
Production:
Fraction of
Dispersion:
2.0xl06lbs.
1.0
Release Rate (million Ibs/yr): 2.0
Herban
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LD50
TOXICITY DATA
Animal
1470 mg/kg
2000 mg/kg
4600 mg/kg
3700 mg/kg
rat
rat
mouse
dog
Route
oral
not reported
oral
oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinqgenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-43
-------
Hexachloroethane
CHEMICAL NAME
CAS Number: 67-72-1
Chemical Name: Hexachloroethane
Synonyms: Carbon hexachloride
Perchloroe thane
Molecular
Formula: C2C16
Structure: C13C - C C13
Chemical Properties
Molecular Weight: 236.76
Vapor Pressure: l mm at 32.7°C
Boiling Point: 186.6°C (sublimes)
Density: 2.091 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
E nvironmental Persistence
BOO:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 185°C
Sol u bil ity: Insoluble (H2 O)
Safety Hazard: Explosion-slight
Disaster hazard-when heated to decomposition, emits phosgene
AIII-44
-------
Hexachloroethane
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITV DATA
Acute Toxicity Dosage Animal Route
LCLo 325 mg/kg dog intravenous
4000 mg/kg rabbit subcutaneous
Non-lethal Acute Effects:
Liver injury
Irritant to eyes
Mild narcosis
Chronic Toxicity
U.S. Occupational Standard: (air): TWA 1 ppm (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-45
-------
Hexachloronaphthalene
CHEMICAL NAME
CAS Number: 1335-87-1
Chemical Name: Hexachloronaphthalene
Synonyms: Chloronaphthalene
Molecular
Formula: C10H2C16
Structure:
Chemical Properties
Molecular Weight: 334.9
Vapor Pressure:
Boiling Point: >288°C
Density: >1.40atl49°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Disaster hazard-dangerous-chlorides
Physical State: Solid
Vapor Density:
Melting Point: >88°C
Solubility: Insoluble (H2O)
AIII-46
-------
Hexachloronaphthalene
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity Dosage
LDLo llmg/kg
Non-lethal Acute Effects:
Acneform eruptions
Toxic narcosis of the liver
Animal
cattle
Route
oral
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 200 Mg/m3 (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
All1-47
-------
Hexalene glycol
CHEMICAL NAME
CAS Number: 629-11-8
Chemical Name: 1,6-Hexanediol
Synonyms:
Molecular
Formula:
Hexalene glycol
Hexamethylene glycol
C6H,402
Structure: HO - CH2 - (CH2)4 - CH2OH
Chemical Properties
Molecular Weight: 118.18
Vapor Pressure: <10 mm at 25°C
Boiling Point: 250°C at 760 mm
Density: 0.967 at 0°C/4*C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 4.07
Melting Point: 41 to 42°C
Solubility: Soluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
AIII-48
-------
Hexalene glycol
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 3730 mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-49
-------
Hexamethylenetetramine
CHEMICAL NAME
CAS Number: 100-97-0
Chemical Name: Hexamethylenetetramine
Synonyms: Methenamine
Formamine
Hexamine
Molecular
Formula: C6H12N4
Urotropin
Metiamine
Hexaform
Ammonioformaldehyde
Formin
Hexamethyleneamine
1,3,5,7-Tetraazaadamantane
Structure:
Chemical Properties
Molecular Weight: 140.19
Vapor Pressure:
Boiling Point: Sublimes
Density: 1.331 at -5°C
Octanol/Water Parti-
tion Coefficient: -2.34
Environmental Persistence
BOD: 2% of theoretical after 5 days at 20°C
Total theoretical oxygen demand = 3.19 gm/gm
Atmospheric Reactivity:
Activity: reacts slowly with RO? and Os
will react with oxidizing materials
Activity toward OH: tw = 9.6 hr.
Hydrolyzes rapidly at pH 3 or 7, ti^ = 1 day
Safety Hazard: Fire-Moderate
Physical State: Solid
Vapor Density:
Melting Point: 285 to 295°C
Solubility: Very soluble (666 gm/1 H2O)
AIII-50
-------
Hexamethylenetetramine
PRODUCTION DATA
Annual U.S.
Production: 101 x 106 Ibs.
Fraction of
Dispersion: 0.62
Release Rate (million Ibs/yr): 63.6
Consumption: 101 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
Dosage
9200 mg/kg
200 mg/kg
512 mg/kg
Animal
rat
rat
mouse
Route
intravenous
subcutaneous
intraperitoneal
Non-lethal Toxic Effects:
Deimatitis
Vesicular lesions
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Neoplastic effects (sarcomas and adenomas):
TO
Lo
144 gm/kg (72 weeks) - rat
subcutaneous
Lymphomas mouse
Mutagenicity: Slight in mice, no details
Teratogenicity: TLV:
Other Chronic Effects: Kidney damage
oral
AIII-51
-------
Hexanediamine
CHEMICAL NAME
CAS Number: 124-09-4
Chemical Name: 1,6-Hexanediamine
Synonyms: Hexamethylene diamine
HMDA
Molecular
Formula:
Structure: HjN - CHjCHjCHjCHjCHjCHj - NH2
Chemical Properties
Molecular Weight: 116.21 Physical State: Solid
Vapor Pressure: Vapor Density:
Boiling Point: 205°C Melting Point: 39-42°c
Density: Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-Slight
AIII-52
-------
Hexanediamine
PRODUCTION DATA
Annual U.S.
Production: 613.4 x 106lbs. (1970) Consumption: 1224.4 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 0.01 duction Lost: 0.015
Release Rate (million Ibs/yr): 12.8
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Irritation of eyes and mucous membranes
Hepatitis
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
All1-53
-------
Hydrogen cyanide
CHEMICAL NAME
CAS Number: 74-90-8
Chemical Name: Hydrocyanic acid
Synonyms: Hydrogen cyanide
Prussic acid
Molecular
Formula: CHN
Structure: HC = N
Chemical Properties
Molecular Weight: 27.03 Physical State: Liquid
Vapor Pressure: 739.36 mm at 25°C Vapor Density: 0.932
Boiling Point: 25.7°C at 760 mm Melting Point: -13.3°C
Density: 0.6876 at 20°C/4°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AIII-54
-------
Hydrogen cyanide
PRODUCTION DATA
Annual U.S.
Production: 141.6 x 106
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Acute Toxicity
LDSO
LDLo
LCSO
LCLo
Ibs. (1976 capacity)
TOXICITY
Dosage
3700 jug/kg
2990 Mg/kg
11 00 Mg/kg
2700 us/kg
1570 Mg/kg
2500 Mg/kg
820 Mg/kg
1100 Mg/kg
570 Mg/kg
3 mg/kg
4 mg/kg
1700 /ug/kg
2 mg/kg
11 00 Mg/kg
100 jug/kg
544 ppm (5 months)
169 ppm (30 months)
300 ppm (3 months)
120mg/m3 (1 hours)
2500 mg/m3
600 mg/m3 (2 months)
Consumption: 365 x
Fraction of Pro-
duction Lost: 0.015
DATA
Animal
mouse
mouse
mouse
mouse
rabbit
rabbit
rabbit
rabbit
human
mouse
dog
dog
cat
cat
guinea pig
rat
mouse
dog
human
cat
rabbit
106 Ibs.
Route
oral
intraperitoneal
intravenous
intramuscular
intraperitoneal
subcutaneous
intravenous
intramuscular
oral
subcutaneous
oral
subcutaneous
oral
subcutaneous
subcutaneous
inhalation
inhalation
inhalation
inhalation
inhalation
inhalation
Protoplasmic poison-halts cellular oxidation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 10 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
. . _ . .
TLV: 10 ppm
AllI-55
-------
Hydroquinone
CHEMICAL NAME
CAS Number: 123-31-9
Chemical Name: Hydroquinone
Synonyms: p-Hydroquinone
1,4-Benzenediol
Quinol
Molecular
Formula: C6H6O
Hydroquinol
Structure:
HO
OH
Chemical Properties
Molecular Weight: 110.6
Vapor Pressure: 1 mm at 132.4bC
Boiling Point: 286.2°C
Density: 1.358 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Solid
Vapor Density: 3.81
Melting Point:
Solubility: Soluble (H2O)
Environmental Persistence
BOD: 53% of theoretical
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
AIII-56
-------
Hydroquinone
PRODUCTION DATA
Annual U.S.
Production: 29.7 x 106 Ibs
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
(1976 capacity)
Consumption:
Fraction of Pro-
duction Lost: 0.015
TOXIGITY DATA
Acute Toxicity
LDso
LDLo
Non-lethal Acute Effects:
Dermatitis
Neurological effects
Chronic Toxicity
U.S. Occupational Standard
Carcinogenicity:
Neoplastic:
TOLo
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Dosage
370 mg/kg
170mg/kg
320 mg/kg
115 mg/kg
400 mg/kg
190 mg/kg
200 mg/kg
70 mg/kg
125 mg/kg
550 mg/kg
300 mg/kg
200 mg/kg
100 mg/kg
150 mg/kg
190 mg/kg
800 mg/kg
Animal
cat
rat
rat
rat
mouse
mouse
dog
cat
rabbit
guinea pig
pigeon
rat
mouse
guinea pig
frog
Jaundice
Nausea and vomiting
mouse
TLV: 2mg/m3
Route
oral
intraperitoneal
oral
intravenous
oral
subcutaneous
oral
oral
intraperitoneal
oral
oral
subcutaneous
intraperitoneal
intraperitoneal
parenteral
skin
AIII-57
-------
Indene
CAS Number: 95-13-6
Chemical Name: lH-Indene
Synonyms:
Molecular
Formula:
Indonaphthene
Indene
Inden
C9H8
CHEMICAL NAME
Structure:
Chemical Properties
Molecular Weight: 116.2
Vapor Pressure: 2.23 mm at 25°C
Boiling Point: 182.6°C at 760 nun
Density: 0.9968 at 20°C/4?C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density:
Melting Point: -1.8 to -1.5°C
Solubility: Insoluble (H2O)
Safety Hazard:
AH 1-5 8
-------
Indene
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
Non-lethal Actue Effects:
Local irritant
TOXICITY DATA
Dosage Animal
Route
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 10 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-59
-------
Isoamyl alcohol
CHEMICAL NAME
CAS Number: 123-51-3
Chemical Name: Isopentyl alcohol
Synonyms: Isoamyl alcohol, primary
Fusel oil
Molecular
Formula: C5H12O
CH3
I
Structure: CH3 - CH - CH2 - CH2OH
Chemical Properties
Molecular Weight: 88.15
Vapor Pressure: <10 mm at.25°C
Boiling Point: 132°C
Density: 0.813 at 15°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Isobutyl carbinol
3,3-Dimethyl-l-propanol
Safety Hazard: Fire-moderate
Explosion-slight
Physical State: Liquid
Vapor Density: 3.04
Melting Point: -117.2°C
Solubility: Slightly (H2O)
AIII-60
-------
Isoamyl alcohol
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 1300mg/kg rat oral
3970 mg/kg rabbit skin
LDLo 813 mg/kg rat intraperitoneal
4250 mg/kg rabbit oral
Non-lethal Acute Effects:
Irritant to eyes and skin
Chronic Toxicity
U.S. Occupational Standard: (aii) TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: tLV:
Other Chronic Effects:
AllI-61
-------
Isobutyl acetate
CHEMICAL NAME
CAS Number: 110-19-0
Chemical Name: Acetic acid, isobutyl estei
Synonyms: Isobutyl acetate
Molecular
Formula: C6H,2O2
O CH,
II I 3
Structure: CH3 - C - OCH2 - CH
Chemical Properties
Molecular Weight: 116.2
Vapor Pressure: 19.61 mmat 25°C
Boiling Point: 118.0°C at 760 mm
Density: 0.8712 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard: Fire-dangerous
Physical State: Liquid
Vapor Density: 4.0
Melting Point: -99°C
Solubility: Slightly soluble (H2O)
AIII-62
-------
Isobutyl acetate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 4760 mg/kg rabbit oral
LC]_,0 8000 ppm (4 hours) rat inhalation
Non-lethal Acute Effects:
Narcotic
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 150 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 150 ppm
Other Chronic Effects:
AIII-63
-------
Isobutyl alcohol
CHEMICAL NAME
CAS Number: 78-83-1
Chemical Name: Isobutyl alcohol
Synonyms: 2-Methylpropanol
Isopropyl caibinol
Molecular
Formula: C4H8O
Structure:
CH,
H3C - C - C - OH
H
Chemical Properties
Molecular Weight: 74.12
Vapor Pressure: 12.6 mm at 25°C
Boiling Point: 107.9
Density: 0.805 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 0.97
Environmental Persistence
BOD: 81% of theoretical after 20 days at 20°C
Total theoretical oxygen demand = 2.6 gm/gm
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density: 2-55
Melting Point: -108°C
Solubility: Soluble (40 gm/lH2O)
Safety Hazard: Fire-moderate
Explosion—moderate
Disaster hazard-moderate-toxic fumes
AIII-64
-------
Isobutyl alcohol
PRODUCTION DATA
Annual U.S.
Production: 96.4 x 106 Ibs.
Fraction of
Dispersion: 0.25
Release Rate (million Ibs/yr): 29.5
Consumption: 96.4 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LDso
LDLo
LCLo
Non-lethal Acute Effects:
Local irritant
Conjunctivitis
Dermatitis
Dosage
2460 mg/kg
4240 mg/kg
3750 mg/kg
8000 ppm (4 hours)
Animal
rat
rabbit
rabbit
rat .
Route
oral
skin
oral
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 100ppm
AIII-65
-------
IsobutyI aldehyde
CHEMICAL NAME
CAS Number: 78-84-2
Chemical Name: Isobutyraldehyde
Synonyms: Isobutyl aldehyde
2-Methyl propaldehyde
tsobutanal
Molecular
Formula: C4H8O
_
Structure: H,C - CH - C
3
_
O
Chemical Properties
Molecular Weight: 72.12
Vapor Pressure: 210 mm at 25°C
Boiling Point: 64°C
Density: 0,794 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: -66°C
Solubility: Insoluble (H2O)
AIII-66
-------
Isobutylaldehyde
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 2810mg/kg rat oral
8000 ppm (4 hours) rat inhalation
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: ' TLV:
Other Chronic Effects:
AIII-67
-------
Isobutylene
CHEMICAL NAME
CAS Number: 115-11-7
Chemical Name: 2-Methyl-l-propene
Synonyms:
Molecular
Formula:
Isobutylene.
Isobutene
2-Methylpropene
C4H8
CH
_^
Structure: ~H^C-~C=CH2
Chemical Properties
Molecular Weight: 56.1
Vapor Pressure: 3290 mm at 40.5° C
Boiling Point: -6.9°C
Density: 0.600 at 20°C/4°C (liquid)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Liquid/liquified gas
Vapor Density: 1.94
Melting Point: -140.35°C
Solubility: Insoluble (H2O)
Safety Hazard:
' Fire-dangerous
AIII-68
-------
Isobutylene
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: . duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
All1-69
-------
Isobutyric acid
CHEMICAL NAME
CAS Number: 79-31-2
Chemical Name: Isobutyric acid
Synonyms: 2-Methylpropanoic acid
Molecular
Formula: C4H8O2
CH3
\
Structure: CH - C -~OH~
_ _
CH3 O
Chemical Properties
Molecular Weight: 88.1 Physical State: Liquid
Vapor Pressure: 2.67 mm at 25°C Vapor Density: 3.04
Boiling Point: 153.2°C at 760mm Melting Point: -46.1°C
Density: 0.949 at 20°C/4°C Solubility: Very Soluble (H2O)
Octanol/Water Parti-
tion Coefficient: 1.00
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AIII-70
-------
Isobutyric acid
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 280mg/kg rat oral
500 mg/kg rabbit skin
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-71
-------
Isodecyl alcohol
CHEMICAL NAME
CAS Number: (Mixture)
Chemical Name:
Synonyms: Isodecyl alcohol
Isodecanol
Molecular
Formula:
Structure: Mixture of CIQ alcohols, predominantly trimethyl heptanols
Chemical Properties
Molecular Weight: 158.32 Physical State: Liquid
Vapor Pressure: <.01 mm at 20°C Vapor Density: 5.5
Boiling Point: 220.1°C Melting Point:
Density: 0.8395 Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD: 32% of theoretical after 20 days at 20°C
Total theoretical oxygen demand = 3.03 gm/gm.
Atmospheric Reactivity:
Safety Hazard:
Fire-moderate
AIII-72
-------
Isodecyl alcohol
PRODUCTION DATA
Annual U.S.
Production: 147 x 106 Ibs. Consumption: 147 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 0-5 duction Lost: 0.15
Release Rate (million Ibs/yr): 75.7
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-73
-------
Isooctyl alcohol
CHEMICAL NAME
CAS Number: 26952-21-6
Chemical Name: Isooctanol
Synonyms: Isooctanol (isomei mix)
Molecular
Formula: C8H18O
Structure: (C7H15)CH2OH
Chemical Properties
Molecular Weight: 130.26
Vapor Pressure:
Boiling Point: 182 to 195°C
Density: 0.832 at 20°C/20°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility:
AIII-74
-------
Isooctyl alcohol
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr): 15.8 (1972)
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 1480 mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AllI-75
-------
Isooctylphenol, ethoxylated
CHEMICAL NAME
CAS Number: 11059-29-3
Chemical Name: 26-dsooctylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-l-ol
Synonyms: Octylphenol polyglycol ethei
Isooctylphenoxypolyoxyethylene ethanol
Molecular
Formula: C32Hs8Oio
CH,
CH,
Structure: CH, - C - CH2 - C
I I
CH,
CH,
OC H2CH2 - O - (C2H4O)7 CH2CH2OH
Chemical Properties
Molecular Weight:
Vapor Pressure:
Boiling Point: 150°C at 1 mm
Density: 1.06at20°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density:
Melting Point: 2 to 5°C
Solubility:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-slight
Disaster hazard—dangerous-toxic fumes
AIII-76
-------
Isooctylphenol, ethoxylated
PRODUCTION DATA
Annual U.S.
Production: 20 x 106 Ibs.
Fraction of
Dispersion: 1-0
Release Rate (million Ibs/yr): 20.6
Consumption: 20 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.03
Acute Toxicity
LD50
for x = 3
x = 5
x = 8-10
x= 12-131
x=16
x = 20
TOXICITY DATA
Dosage Animal
4000 mg/kg
3800 mg/kg
1800 mg/kg
900 mg/kg
2800 mg/kg
3600 mg/kg
rat
rat
rat
rat
rat
rat
where x denotes the number of ethoxy groups
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
Route
oral
oral
oral
oral
oral
oral
AIII-77
-------
Isophorone
CHEMICAL NAME
CAS Number: 78-59-1
Chemical Name: 3,5,5-Trimethyl-2-cyclohexen-l-one
Synonyms: Isophorone
Molecular
Formula: C9H14O
O
Structure:
Chemical Properties
Molecular Weight: 138.1
Vapor Pressure: 1 mm at 38°C
Boiling Point: 215.2°C
. Density: 0.9229 at 20°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 4.77
Melting Point: -8.1°C
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AIII-78
-------
Isophorone
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 2330mg/kg rat oral
Non-lethal Acute Effects:
Local irritant
Lachrymation, opacity of cornea
Kidney poisoning
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 25 ppm
Other Chronic Effects:
AIII-79
-------
Isophthalic acid
CHEMICAL NAME
CAS Number: 121-91-5
Chemical Name: Isophthalic acid
Synonyms: Benzenedicarboxylic acid
Isophthalic acid
Molecular
Formula:
O ^ OH
* C "
Structure:
OH
\v
C
o
Chemical Properties
Molecular Weight: 166.14
Vapor Pressure: <10 mm at 25°C
Boiling Point: Sublimes
Density: !-593
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard: Fire-slight
Physical State: Solid
Vapor Density:
Melting Point: 348°C
Solubility: Slightly soluble (H2O)
AIII-80
-------
Isophthalic acid
PRODUCTION DATA
Annual U.S.
Production: 100 x 106 Ibs. (1976 capacity) Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITYDATA
Acute Toxicity Dosage Animal Route
LDSo 4200 mg/kg mouse intraperitoneal
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-81
-------
Isoprene
CHEMICAL NAME
CAS Number: 78-79-5
Chemical Name: Isoprene
Synonyms: 2-Methyl-l,3-butadiene
Molecular
Formula: C5H8
CH3
Structure: CH2 = C - C = CH2
' I
H
Chemical Properties
Molecular Weight: 68.13 Physical State: Liquid
Vapor Pressure: 600.93 mm at 25°C Vapor Density: 2.35
Boiling Point: 34°Cat760mm Melting Point: -146°C
Density: 0.6806 at 20°C/4°C Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fiie-very dangerous
AIII-82
-------
Isoprene
PRODUCTION DATA
Annual U.S.
Production:
Fraction of
Dispersion:
467 x 106 Ibs. (1976 capacity)
0.01
Release Rate (million Ibs/yr):
Consumption:
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity Dosage
Concentrations of 5% are fatal to mice
LCLo 144 mg/m3
180mg/m3
Non-lethal Acute Effects:
Irritant to eyes and mucous membranes
Anaesthesia at high concentration
Animal
mouse
rat
Route
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AllI-83
-------
Isopropyl acetate
CHEMICAL NAME
CAS Number: 108-214
Chemical Name: Acetic acid, 1-methyl ethyl ester
Synonyms: Isopropylacetate
Molecular
Formula:
O
Structure: CH3 - C - O - CH
Chemical Properties
Molecular Weight: 102.13
Vapor Pressure: 58.8 mm at 25°C
Boiling Point: 90°C at 760 mm
Density: 0.8718 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
CH,
CH3
Physical State: Liquid
Vapor Density: 3.52
Melting Point: -73.4°C
Solubility: Soluble (H2O)
Environmental Persistence
BOD: 13% of theoretical
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-dangerous
Explosion-moderate
AllI-84
-------
Isopropyl acetate
PRODUCTION DATA
Annual U.S.
Production: 41.9 x 106 Ibs., 1967 Consumption:
(40 x 106 Ibs., 1976 capacity)
Fraction of Fraction of Pro-
Dispersion: 0.01 duction Lost: 0.015
Release Rate (million Ibs/yr): 24.8
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LC 3.2% rat
TCLQ 200 ppm human inhalation
LD50 3000mg/kg rat oral
Non-lethal Acute Effects:
Irritant to eyes, skin, and mucous membranes
Narcotic
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 250 ppm
Other Chronic Effects: Liver damage
AllI-85
-------
Isopropyl alcohol
CHEMICAL NAME
CAS Number: 67-63-0
Chemical Name: Isopropyl alcohol
Synonyms: 2-Propanol
sec-Propyl alcohol
Dimethylcarbinol
Molecular
Formula: C3H8O
OH
I
Structure: CH3 - C - CH3
I
H
Chemical Properties
Molecular Weight: 60.09 Physical State: Liquid
Vapor Pressure: 44.29 mm at 2S°C Vapor Density: 2.07
Boiling Point: 82.4°C at 760 mm Melting Point: -89.5°C
Density: 0.7854 at 20°C/4°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD: 78% of theoretical after 20 days at 20°C
Total theoretical = 2.4 gm/gm
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-dangerous
Explosion-moderate
AllI-86
-------
Isopropyl alcohol
PRODUCTION DATA
Annual U.S.
Production: 1790xl06lbs.
Fraction of
Dispersion: 0.50
Release Rate (million Ibs/yr): 876.2
Consumption: 1698.6 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD10o
LD
so
LD
Lo
Non-lethal Acute Effects:
Conjunctivitis
| Anemia
Irritant
Dosage
5000 mg/kg
6000 mg/kg
933 mg/kg
6000 mg/kg
16 mg/kg
2371 mg/kg
192 mg/kg
1963 mg/kg
6 mg/kg
400 ppm
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 400 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rabbit
mouse -
mouse
dog
rabbit
human
mouse
cat
mammal
Route
oral
subcutaneous
intraperitoneal
oral
skin
oral
oral
intravenous .
subcutaneous
human
inhalation
TLV: 400 ppm
AI11-87
-------
Isopropylamine
CHEMICAL NAME
CAS Number: 75-31-0
Chemical Name: Isopropylamine
Synonyms: 2-Aminopropane
Molecular
Formula: C3H9N
NH2
I
Structure: C% - C - CH3
I
H
Chemical Properties
Molecular Weight: 59.11 Physical State: Liquid
Vapor Pressure: 321.2 mmat 25°C Vapor Density: 2.03
Boiling Point: 32.4°C at 760 mm Melting Point: -95.2°C
Density: 0.694 at 15°C/4°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient: -0.13
Environmental Persistence
BOD: 34% of theoretical after 10 days at 20°C
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-dangerous
AIII-88
-------
Isopropylamine
PRODUCTION DATA
Annual U.S.
Production: 18 x 106 ibs. Consumption:
Fraction of Fraction of Pro-
Dispersion: 0.01 duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 820mg/kg rat oral
550mg/kg rabbit skin
LCLo 800 ppm (8 hours) Tat inhalation
7000 ppm (40 months) mouse inhalation
Non-lethal Acute Effects:
Strong irritant causing sensitivity of skin and mucous membranes
Narcotic in high concentrations
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 5 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 5 ppm
Other Chronic Effects:
AIII-89
-------
Isopropyl chloride
CHEMICAL NAME
CAS Number: 75-29-6
Chemical Name: 2-Chloiopropane
Synonyms: Isopropyl chloride
Isoprid
Molecular
Formula: C3H7C1
Cl
Structure: CH3 - CH - CH3
Chemical Properties
Molecular Weight: 78.55 Physical State: Liquid
Vapor Pressure: 534.5 mm at 25°C Vapor Density: 2.71
Boiling Point: 35.74°Cat 760mm Melting Point: -117.6°C
Density: 0.8617 at 20°C/4°C Solubility: Slightly soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-highly dangerous
Explosion—moderate
Disaster hazard—dangerous—toxic fumes—chlorides and phosgene
AllI-90
-------
Isopropyl chloride
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
Non-lethal Acute Effects:
Anaesthetic
TOXICITY DATA
Dosage Animal
Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-91
-------
Isopropyl ether
CHEMICAL NAME
CAS Number: 108-20-3
Chemical Name: Isopropyl ether
Synonyms: 2-Isopropoxypropane
Diisopropyl ether
Molecular
Formula: C6H14O
Structure:
CH,
CH,
Chemical Properties
Molecular Weight: 102.17
Vapor Pressure: 150 mm at 25°C
Boiling Point: 68.5°C
Density: 0.719at25°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 3.52
Melting Point: -88°C
Solubility: Soluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-highly dangerous
Explosion-severe
Disaster hazard-dangerous—toxic fumes-peroxides
AIII-92
-------
Isopropyl ether
PRODUCTION DATA
Annual U.S.
Production: 14 x 105 Ibs.
Fraction of
Dispersion: 1-0
Release Rate (million Ibs/yr): 14.2
Consumption: 14 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LDSO
Non-lethal Acute Effects:
Irritant
TDLo
TOXICITY DATA
Dosage Animal
812mg/kg mouse
800 ppm (5 minutes) human
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 500 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects: Narcotic at high concentrations
Route
intiaperitoneal
inhalation
AIII-93
-------
o-lsopropylphenol
CHEMICAL NAME
CAS Number: 88-69-7
Chemical Name: o-Isopiopylphenol
Synonyms: l-Hydroxy-2-isopropyl benzene
o-Cumenol
Molecular
Formula: C9H12O
Structure:
CH
OH
CH,
CH,
Chemical Properties
Molecular Weight: 136.20
Vapor Pressure: 1 mm at 56.6°C
Boiling Point: 213 to214°Cat760mm
Density: 0.995 at 25°C/25°C
Octanol/Water Parti-
tion Coefficient: 1-08
Physical State: Liquid
Vapor Density:
Melting Point: 15 to 16°C
Solubility: Slightly soluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire—moderate
Disaster hazard-dangerous-toxic fumes-phenol
AIII-94
-------
o-lsopropylphenol
PRODUCTION DATA
Annual U.S.
Production: 2084 x 106 ibs. (1976 capacity) Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage : Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-95
-------
p-lsopropylphenol
CHEMICAL NAME
CAS Number: 99-89-8
Chemical Name: p-Isopropyl phenol
Synonyms: p-Cumenol
1 -Hy droxy-4-isopropylphenol
Molecular
Formula: C9H12O
Structure:
Chemical Properties
Molecular Weight: 136.2 Physical State: Liquid
Vapor Pressure: lmmat67°C Vapor Density:
Boiling Point: 228°C at 745 mm Melting Point: 63.2°C
Density: 0.983 Solubility: Slightly soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Disaster hazard-dangeious-toxic fumes-phenol
AIII-96
-------
p-lsopropylphenol
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-97
-------
Ketene
CAS Number: 463-51-4
Chemical Name: Ketene
Synonyms: Ethenone
Carbomethane
Keten
Molecular
Formula: C2H2O
CHEMICAL NAME
Structure:
= C = O
Chemical Properties
Molecular Weight: 42.04
Vapor Pressure:
Boiling Point: -S6°C
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Gas
Vapor Density: 1.45
Melting Point: -151°C
Solubility: Decomposes (HjO)
Safety Hazard:
AllI-98
-------
Ketene
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITYDATA
Acute Toxicity Dosage Animal Route
LD50 1300mg/kg rat unreported
LCj_,0 23 ppm (30 minutes) mouse inhalation
53 ppm (100 minutes) rat • inhalation
53 ppm (4 hours) guinea pig inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 0.5 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
Pulmonary edema
AIII-99
-------
Ligninsulfonic acid, ammonium salt
CHEMICAL NAME
CAS Number: Not listed in 9th Chemical Index
Chemical Name: (Complex mixture)
Synonyms: Ligninsulfonic acid, ammonium salt
Molecular
Formula: (Complex mixture)
Structure: (Several structures are proposed)
Chemical Properties
Molecular Weight: 1,000 to 20,000 Physical State: Solid
Vapor Pressure: Negligible at 25°C Vapor Density:
Boiling Point: Decomposes above 200°C Melting Point:
Density: ca. 1.5 Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AIII-100
-------
Ligninsulfonic acid, ammonium salt
PRODUCTION DATA
Annual U.S.
Production: 40xl06lbs. Consumption: 40xl06lbs.
Fraction of Fraction of Pro-
Dispersion: °-98 duction Lost: 0.03
Release Rate (million Ibs/yr): 40.4
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-101
-------
Ligninsulfonic acid, calcium salt
CHEMICAL NAME
CAS Number: (Not listed in 9th Chemical Index)
Chemical Name: (Complex mixture)
Synonyms: Ligninsulfonic acid, calcium salt
Molecular
Formula: (Complex mixture)
Structure: (Several structures are proposed)
Chemical Properties
Molecular Weight: (Unknown)
Vapor Pressure: Negligible
Boiling Point: Decomposes
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State:
Vapor Density:
Melting Point:
Solubility: Infinite (H2O)
All I-102
-------
Ligninsulfonic acid, calcium salt
PRODUCTION DATA
Annual U.S.
Production: 326.6 x 106 Ibs. Consumption: 326.6 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 0.98 duction Lost: 0.03
Release Rate (million Ibs/yr): 329.9
TOXICITY DATA
Acute Toxicity Dosage ; Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-103
-------
Ligninsulfonic acid, ferrochrome salt
CHEMICAL NAME
CAS Number: (Not listed in 9th Chemical Index)
Chemical Name: (Complex mixture)
Synonyms: Ligninsulfonic acid, ferrochrome salt
Molecular
Formula: (Complex mixture)
Structure: (Several structures are proposed)
Chemical Properties
Molecular Weight: (Unknown)
Vapor Pressure: Negligible
Boiling Point: Decomposes
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State:
Vapor Density:
Melting Point:
Solubility: Infinite
AllI-104
-------
Ligninsulfonic acid, ferrochrome salt
PRODUCTION DATA
Annual U.S.
Production: 60xl06lbs. Consumption: 60xl06lbs.
Fraction of Fraction of Pro-
Dispersion: 0.98 duction Lost: 0.03
Release Rate (million Ibs/yr): 60.6
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-105
-------
Ligninsulfonic acid, sodium salt
CHEMICAL NAME
CAS Number: Not listed in 9th Chemical Index
Chemical Name: (Complex mixture)
Synonyms: Ligninsulfonic acid, sodium salt
Molecular
Formula: (Complex mixture)
Structure: (Several structures are proposed)
Chemical Properties
Molecular Weight: (Unknown) Physical State:
Vapor Pressure: Negligible at 25°C Vapor Density:
Boiling Point: Decomposes Melting Point:
Density: Solubility: Infinite
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AIII-106
-------
Ligninsulfonic acid, sodium salt
PRODUCTION DATA
Annual U.S.
Production: 58.7 x 106 Ibs. Consumption: 58.7 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 0.98 duction Lost: 0.03
Release Rate (million Ibs/yr): 59.3
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
#
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
All I-10 7
-------
Lindane
CHEMICAL NAME
CAS Number: 58-89-9
Chemical Name: 1,2,3,4,5,6-Hexachloiocyclohexane (gamma isomer)
Synonyms: Gamma-benzene hexachloride
Gammexane
Molecular
Formula: C6H6C16
Chemical Properties
Molecular Weight: 290.82 Physical State: Solid
Vapor Pressure: 0.0317 mm at 20°C Vapor Density:
Boiling Point: 323.4°C at 760 mm Melting Point: 112.5°C
Density: Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Disaster hazard-dangerous-phosgene
AIII-108
-------
Lindane
PRODUCTION DATA
Annual U.S.
Production: <1.0xl06lbs. Consumption:
Fraction of Fraction of Pro-
Dispersion: Estimated as 1.0 duction Lost:
Release Rate (million Ibs/yr): <1.0
TOXICITY DATA
Acute Toxicity Dosage Animal
LDSO 88 mg/lg rat
500 mg/lg rat
86 mg/lg mouse
60 mg/lg rabbit
50 mg/lg rabbit
1 27 mg/lg guinea pig
180 mg/lg child
840 mg/lg human
35 mg/lg rat
75 mg/lg mouse
50 mg/lg dog
8 mg/lg dog
4000 Mg/kg rabbit
100 mg/kg wild bird
26 mg/kg wild bird
Non-lethal Acute Effects:
Local irritant-dermatitis
CNS stimulation-convulsions
Necrosis of blood vessels in lungs, liver and kidney
Pulmonary edema
Chronic Toxicity
U.S. Occupational Standard: (air) 500 mg/m3(skin)
Carcinogenicity:
Mutagenicity:
TDLo 29 gm/kg (52 weeks) mouse
Teratogenicity: TLV:
Other Chronic Effects:
0.015
Route
oral
skin
oral
oral
skin
oral
oral
oral
intraperitoneal
intraperitoneal
oral
intravenous
intravenous
oral
intramuscular
oral
AIII-109
-------
Linuron
CHEMICAL NAME
CAS Number: 330-55-2
Chemical Name: 3-(3,4-Dichlorophenyl)-l-methoxyl-l-methyl urea
Synonyms: Methoxy-l-methyl-3(3,4-dichlorophenyl)urea
Molecular
Formula: C9H10C12N2O2
Structure:
Cl
O CH,
" '
NH - C - N - OCH,,
Cl
Chemical Properties
Molecular Weight: 249.11
Vapor Pressure:
Boiling Point:
Density:
Octanot/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 93 to 94°C
Solubility: Slightly (H2O) (75 ppm at 25°C)
Safety Hazard:
AllI-110
-------
Linuron
PRODUCTION DATA
Annual U.S.
Production: 2.0 x 106 Ibs. Consumption:
Fraction of Fraction of Pro-
Dispersion: Estimated as 1.0 duction Lost: 0.015
Release Rate (million Ibs/yr): 2.0
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 1500 mg/kg rat unreported
3300 mg/kg rat oral
500 mg/kg dog oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
Irritant of nose, eyes, throat and skin
AIII-111
-------
Magenta
CHEMICAL NAME
CAS Number: 3248-93-9
Chemical Name: 4-[(4-Aminophenyl)(4-imino-2,5-cyclohexadien-l-ylidene)methyl] -2-methyl benzenamine
Synonyms:
Molecular
Formula:
Structure:
Magenta Rosaniline
Magenta I Fuchsin
a -(p-Aminophenyl)-a (4-imino-2,5-cyclohexadien-ylidene)-2,4-xylidene
2-Methyl4,4'[(4-imino-2,5-cyclohexadien-l-ylidene)methylene]dianiline monohydrochloride
H2N
Chemical Properties
Molecular Weight: 337.8
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
^^ NH2(+) Cl(~)
Physical State:
Vapor Density:
Melting Point:
Solid
186°C (decomposes)
Solubility: Slightly (H2O)
Safety Hazard:
AIII-112
-------
Magenta
PRODUCTION DATA
Annual U.S.
Production: 0.116 x 106 Ibs. (1964) Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.01S
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDLo 150 mg/kg rabbit oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: Recognized carcinogen
Neoplastic effects:
TDLo 2500 mg/kg (52 weeks) mouse oral
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-113
-------
Malathion
CHEMICAL NAME
CAS Number: 121-75-5
Chemical Name: Mercapto-succinic acid, diethyl ester, S-estei with O.O-dimethyl phosophorodithioate
Synonyms: Malathion
O,O-Dimethyl-S-l,2-bis (ethoxy carbonyl) ethyl dithiophosphate
Molecular
Formula: C10H19O6PS2
Structure: ^ P - S - CH - C- OCH2CH3
CH3° CH2 - C - OCH2CH3
II
O
Chemical Properties
Molecular Weight: 330.96 Physical State: Liquid
Vapor Pressure: 4 x 10"5 mm at 30°C Vapor Density:
Boiling Point: \56°CatWmm Melting Point: 2.85°C
Density: 1.23 at 25°C/4°C Solubility: Slightly (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AllI-114
-------
Malathion
PRODUCTION DATA
Annual U.S.
Production: 30xl06lbs. (1972)
Fraction of
Dispersion: 1.0
Release Rate (million Ibs/yr): 30.3
Consumption: 30 x 10 Ibs.
Fraction of Pro-
duction Lost: 0.01
Acute Toxicity
LDSO
TOXICITY DATA
599 mg/kg
340 mg/kg
50 mg/kg
193 mg/kg
500 mg/kg
Animal
fat
rat
rat
mouse
mammal
Route
oral
intraperitoneal
intravenous
intraperitoneal
unreported
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 15 mg/m3 (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 15 mg/m3
Other Chronic Effects: Allergic sensitization of skin
AIII-115
-------
Maleic acid
CHEMICAL NAME
CAS Number: 110-16-7
Chemical Name: Maleic acid
Synonyms: Maleinic acid
Toxilic acid
cis-Butenedioic acid
Molecular
Formula: C4H4O4
H
Structure: o = C "
/
OH
C ~
O
OH
Chemical Properties
Molecular Weight: 116.07
Vapor Pressure: Essentially O
Boiling Point: 135°C-decomposes
Density: 1.590 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: -0.79
Environmental Persistence
BOD:
Atmospheric Reactivity:
Stable to ultraviolet irradiation
Safety Hazard: Fire-slight
Physical State: Solid
Vapor Density: 4.0
Melting Point: 139 to 140°C
Solubility: Very soluble (H2O)
All1-116
-------
Maleic acid
PRODUCTION DATA
Annual U.S.
Production: 283.2 x 106 Ibs. (1974) Consumption: ca. 283.2 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 708 mg/kg rat oral
1560 mg/kg rabbit skin
Non-lethal Acute Effects:
Irritant
Hypofunction of glycogen synthesis in liver
Conjunctivitis
Dermatitis
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AllI-117
-------
Maleic anhydride
CHEMICAL NAME
CAS Number: 108-31-6
Chemical Name: Maleic anhydride
Synonyms: Toxilic anhydride
cis Butene dioicanhydiide
Molecular
Formula: C4H2O3
Structure:
Chemical Properties
Molecular Weight: 98.06 Physical State: Solid
Vapor Pressure: 1 mm at 44°C Vapor Density: 3.4
Boiling Point: 197 to 199°C Melting Point: 60°C
Density: 1.48 at 20°C/4°C Solubility: Reacts with water; Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing agents
Safety Hazard: Fire: moderate-toxic fumes
AIII-118
-------
Maleic anhydride
PRODUCTION DATA
Annual U.S.
Production: 211.8 x 106 Ibs. (1975) Consumption: 230 x 106 Ibs. (1975)
Fraction of Fraction of Pro-
Dispersion: 0.01 duction Lost: 0.015
Release Rate (million Ibs/yr): 4.72
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDso 60 mg/kg mouse oral
LDLo 850 mg/kg rat oral
Non-lethal Acute Effects:
Burns to eyes and skin
Pulmonary edema
Chronic Toxicity
U.S. Occupational Standard: (air): TWA 0.25 ppm
Carcinogenicity:
TDLo 610 mg/kg (61 weeks) rat subcutaneous
Mutagenicity:
Teratogenicity: TLV: 0.25 ppm
Other Chronic Effects:
AIII-119
-------
Maleic hydrazide
CHEMICAL NAME
CAS Number: 123-33-1
Chemical Name: l,2-Dihydro-3,6-pyndazinedione
Synonyms: Maleic hydrazide
3,6-Dioxo-l,2,3,6-tetrahydropyridazine
Molecular
Formula: C4H4N2O2
H
Structure:
Chemical Properties
Molecular Weight: 112.09
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Fire: Dangerous-toxic fumes
Physical State: Solid
Vapor Density:
Melting Point: >300°C decomposes
Solubility: Slightiy soluble (H2O)
AIII-120
-------
Maleic hydrazide
Annual U.S.
Production: 3 x 106 Ibs.
Fraction of
Dispersion: 1.0
Release Rate (million Ibs/yr): 3.0
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost: 0.01S
TOXICITY DATA
Acute Toxicity
LDso
LDLo
Dosage
3800 mg/kg
8800 mg/kg
Animal
rat
mouse
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: (suspected)
TDLo 1300 mg/kg (65 weeks) rat
8800 mg/kg ( 3 weeks) mouse
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
Route
oral
subcutaneous
subcutaneous
subcutaneous
AIII-121
-------
Malic acid
CHEMICAL NAME
(dl): 617-48-1
CAS Number: (d): 636-61-3
(1): 97-67-6
Chemical Name: DL - Malic acid . L - Malic acid
D - Malic acid
Synonyms: Hydroxysuctinic acid
Apple.acid-
Molecular
Formula:' C4H6O5
HO O
XC/X
I
H-C-H
Structure:: H-C-OH
I
'C*
HO O
Chemical Properties
Molecular Weight: 134.09 Physical State: Solid
Vapor Pressure: Vapor Density:
150°C (dl) (decomposes)
Boiling Point: 140°C (d and 1) (decomposes) Melting Point: 128°C (dl)
• - - ioo°C (d and 1)
Density: 1.601 at 20°C/4°C(dl) Solubility: Very soluble (H2O)
1.595 at 20°C/4°C(d and 1)
Octanol/Water Parti-
tion Coefficient: -1.53
Environmental Persistence:
BOO:
Atmospheric Reactivity:
Safety Hazard:
AIII-122
-------
Malic acid
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: dilution Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Unspecified optical isomer
LDLo 1600mg/kg rat oral
L (+) isomer
LDLo 5000mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-123
-------
Mela mine
CHEMICAL NAME
CAS Number: 108-78-1
Chemical Name: Melamine
Synonyms: 2,4,6-Triamine-S-triazine
Cyanurotriamide
2,4,6-Ttiamino-l ,3,5-triazine
Molecular
Formula: C3H6N6
Structure:
Chemical Properties
Molecular Weight: 126.13
Vapor Pressure: 50 mm at 315°C
Boiling Point: Sublimes
Density: 1.573 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Disaster Hazard: Dangerous-toxic fumes-cyanides
Physical State: Solid
Vapor Density: 4.34
Melting Point: 354°C (decomposes)
Solubility: Slightly soluble (H2O)
AIII-124
-------
Melamine
PRODUCTION DATA
Annual U.S. _
Production: 170 x 106 Ibs (1973) Consumption: 110 x 106 Ibs. (1975)
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDLo 1600 mg/kg mouse oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-125
-------
Mesitylene
CHEMICAL NAME
CAS Number: 95-63-6
Chemical Name: 1,3,4-Trimethyl benzene
Synonyms: Mesitylene
Molecular
Formula: C9H12
CH,
Structure:
CH,
CH,
Chemical Properties
Molecular Weight: 120.21
Vapor Pressure:
Boiling Point: 164.7°C at 760 mm
Density: 0.8637 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: -44.7°C
Solubility: Insoluble (H2O)
AIII-126
-------
Mesitylene
Annual U.S.
Production:
Fraction of \
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
TOXICITY DATA
Dosage Animal
2400 ppm (24 hours) rat
1500 mg/kg rat
1303 mg/kg guinea pig
Non-lethal Acute Effects:
Narcotic leucopenia and thrombocytopenia
Dermatitis and conjunctivitis
Central nervous system:
10 ppm
human
Route
inhalation
intraperitoneal
intraperitoneal
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 25 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-127
-------
Mesityl oxide
CHEMICAL NAME
CAS Number: 141-79-7
Chemical Name: 4-Methyl-3-penten-2 one
Synonyms: Mesityl oxide
Molecular
Formula: C6Hi0O
Structure:
CH,
CHi
O
I!
C = CH - C - CHo
Chemical Properties
Molecular Weight: 98.14
Vapor Pressure: 9.16 mm at 25°C
Boiling Point: 130°C at 760 mm
Density: 0.8653 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 1.24
Physical State: liquid
Vapor Density: 3.38
Melting Point: -52.85°C
Solubility: Soluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing material
Safety Hazard: Fire-Moderate
AIII-128
-------
Mesityl oxide
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Itas/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 1120mg/kg rat oral
354 mg/kg mouse intraperitoneal
1000 mg/kg rabbit oral
LCLo 1000 ppm (4 hours) rat inhalation
LDj_,0 1000 mg/kg rat intiapeiitoneal
Non-lethal Acute Effects:
Local irritant
Causes opaque cornea
Keratoconus
Extensive necrosis of the cornea
Liver and kidney effects
Damage to lungs
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 25 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 25 ppm
Other Chronic Effects:
AIII-129
-------
Methacrylic acid
CHEMICAL NAME
CAS Number: 79-41-4
Chemical Name: Methacrylic acid
Synonyms: o-Methyl acrylic acid
2-Methyl propenoic acid
Molecular
Formula: C4H6O2
Structure: CH-, =
CH3
I
C - C - OH
II
o
Chemical Properties
Molecular Weight: 86.1
Vapor Pressure: 1 mm at 25.5°C
Boiling Point: 162 to 163°C at 757 mm
Density: 1.0153 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Fire-moderate
Disaster Hazard: dangerous-toxic fumes
Physical State: Liquid
Vapor Density:
Melting Point: 16°C
Solubility: Soluble (H2O)
AIII-130
-------
Methacrylic acid
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: auction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 49mg/kg mouse intraperitoneal
Non-lethal Acute Effects:
Local irritant to eyes and trachea
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-131
-------
Methacrylonitrile
CHEMICAL NAME
CAS Number: 126-98-7
Chemical Name: Methacrylonitrile
Synonyms: 2-Methylpropenitiile
Isoptopene cyanide
Molecular
Formula: C4HSN
CH3
I
Structure: H2C = C - C = N
Chemical Properties
Molecular Weight: 67.09
Vapor Pressure: 72.38 mm at 25°C
Boiling Point: 90.3°C at 760 mm
Density: 0.7998 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: -35.8°C
Solubility: Insoluble (H2O)
AIII-132
-------
Methacrylonitrile
PRODUCTION DATA
Annual U.S.
Production:
Fraction of
Dispersion:
10 x ICTlbs. (1967 capacity)
Consumption:
Fraction of Pro-
duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity
LDSO
LDLo
LC50
Non-lethal Acute Effects:
Dermatitis
Lachrymation
Dosage
250 mg/kg
320 mg/kg
15 mg/kg
65 mg/kg
328 ppm (4 hours)
36 ppm (4 hours)
37 ppm (4 hours)
80 ppm (4 hours)
Animal
rat
rabbit
mouse
mouse
rat
mouse
rabbit
guinea pig
Route
oral
skin
oral
intraperitoneal
inhalation
inhalation
i
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 1 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects: Highly toxic following skin absorption or inhalation
AIII-133
-------
Methallyl alcohol
CHEMICAL NAME
CAS Number: 513-42-8
Chemical Name: 2-Methyl-2-piopen-l-ol
Synonyms: Methallyl alcohol
Methallyl hydroxide
Molecular
Formula: C4H8O
Structure: HO - CH2 - C = CH2
CH,
Chemical Properties
Molecular Weight: 72.12
Vapor Pressure:
Boiling Point: 114.49°C
Density: 0.8540 at 20°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility: Infinite (H2O)
AIII-134
-------
Methallyl alcohol
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDL0 500 mg/kg mouse oral
2000mg/kg rabbit skin
LCLo 2924 ppm (2 hours) mouse inhalation
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-135
-------
Methallyl chloride
CHEMICAL NAME
CAS Number: 563-47-3
Chemical Name: 3-Chloro-2-methyl propene
Synonyms:
Molecular
Formula:
2-Butene-l -chloride
1 -Chloro-2-butene(cis)
(3-Methallyl chloride
C4H7C1
Structure: C = C
/ \
CH2a
Chemical Properties
Molecular Weight: 90.55
Vapor Pressu re: 101.7 mm at 20° C
Boiling Point: 84.1°C at 758 mm
Density: 0.9426 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Liquid
3.12
Physical State:
Vapor Density:
Melting Point:
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fiie-dangerous
Explosion-moderate
Disaster hazard-dangerous-toxic fumes-chlorides
AIII-136
-------
Methallyl chloride
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LCSO
Dosage
Animal
2000 mg/m (24 hours) rat
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
Route
inhalation
AIII-137
-------
Methane
CAS Number: 74-82-8
Chemical Name: Methane
Synonyms: Marsh gas
Methyl hydride
Molecular
Formula: CH4
CHEMICAL NAME
H
Structure: H - C~H~
"if
Chemical Properties
Molecular Weight: 16.04
Vapor Pressure:
Boiling Point: -164°C at 760mm
Density: 0.415at-165°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Residence in atmosphere: 4 to 7 years
Physical State: Gas
Vapor Density: 0.6
Melting Point: -182.48°C
Solubility: Soluble (H2O)
Safety Hazard:
AIII-138
-------
Methane
PRODUCTION DATA
Annual U.S.
Production: 12,400 x 106 Ibs (1964) Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.0IS
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LCso 400 ppm rat inhalation
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-139
-------
Methanearsonic acid
CHEMICAL NAME
CAS Number: 124-58-3
Chemical Name: Methanearsonic acid
Synonyms: Methyl arsonic acid
Molecular
Formula: CH5AsO3
O
II
Structure: CH3 - As - OH
OH
Chemical Properties
Molecular Weight: 139.97
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Solid
Vapor Density:
Melting Point: 160tol61°C
Solubility: Soluble (H2O)
AIII-140
-------
Methanearsonic acid
PRODUCTION DATA
Annual U.S.
Production: 30.7 x 106 Ibs. Consumption: 30.7 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 1.0 duction Lost: 0.01
Release Rate (million Ibs/yr): 31
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSo 3350mg/kg mouse subcutaneous
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-141
-------
Methomyl
CHEMICAL NAME
CAS Number: 16752-77-5
Chemical Name: N-([(Methylamino)caibonyl] oxy)ethanimidothioic acid, methyl estei
Synonyms: S-Methyl-N-[(methylcarbamoyl)-oxy] -thioacetimidate
Molecular
Formula: csHioN2°2s
CH,-S O
N ... ..'/
Structure: c = N - O - C
/ \
H3C N - CH3
TT
Chemical Properties
Molecular Weight: 162.23 Physical State: Solid
Vapor Pressure: Vapor Density:
Boiling Point: Melting Point: 78to79°C
Density: Solubility:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AIII-142
-------
Methomyl
Annual U.S.
Production:
Fraction of
Dispersion:
2.0 x 10° Ibs.
Estimated as 1.0
Release Rate (million Ibs/yr): 2.0
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
0.015
Acute Toxicity
LDso
TOXICITY DATA
Dosage
17 mg/kg
24 mg/kg
15 mg/kg
10 mg/kg
Animal
rat (male)
rat (female)
duck
wild bird species
Route
oral
oral
oral
oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-143
-------
Methoxychlor
CHEMICAL NAME
CAS Number: 72-43-5
Chemical Name: l,l,l-Trichloro-2,2-bis(p-methoxyphenyl) ethane
Synonyms: DMDT
2,2-bis(p-Methoxyphehyl)-l>l>l-trichloroe thane
Methoxychlor
Molecular
Formula: C,6H1SC13O2
H
/=V ' f,—^
Structure: CH3O -(\ ff~c \ ' / OCH3
a -c - a
i
a
Chemical Properties
Molecular Weight: 345.7 Physical State: Solid
Vapor Pressure: Vapor Density: 12
Boiling Point: Melting Point: 94°C
Density: Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Slight air contaminant
Safety Hazard: Disaster hazard: Dangerous-toxic fumes-chlorides
AIII-144
-------
Methoxychlor
PRODUCTION DATA
Annual U.S.
Production:: 10.0 x 106 Ibs. Consumption:
Fraction of Fraction of Pro-
Dispersion: 1.0 duction Lost: 0.015
Release Rate (million Ibs/yr): 10.0
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 5000mg/kg rat oral
6430 mg/kg human . oral
24 14 mg/kg human skin unspecified toxic effects
Non-lethal Acute Effects:
Nausea and vomiting
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 15 mg/m3
Carcinogenicity:
Neoplastic effects
1100 mg/kg (36 weeks) rat oral
Mutagenicity:
Teratogenicity: TLV: 15 mg/m3
Other Chronic Effects: Kidney injury
AIII-145
-------
Methoxyethanol
CHEMICAL NAME
CAS Number: 109-86-4
Chemical Name: 2-Methoxy ethanol
Synonyms: Methyl glycol
Methoxy hydioxy ethane
Methyl cellosolve
Molecular
Formula: C3H8O2
Structure: CH3 - O - CH2 - CH2 - OH
Chemical Properties
Molecular Weight: 76.09
Vapor Pressure: 6.2 mm at 20°C
Boiling Point: 124.6°C
Density: 0.9660 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: -0.82
Environmental Persistence
BOD: 88% of theoretical after 20 days at 20°C
Total theoretical oxygen demand = 1.68 gm/gm
Atmospheric Reactivity:
Reacts with oxidizing materials
Safety Hazard: Fire-Moderate
Physical State: Liquid
Vapor Density: 2.62
Melting Point: -85.1°C
Solubility: Infinite (H2O)
AIII-146
-------
Methoxyethanol
PRODUCTION DATA
Annual U.S.
Production: 119.1 x 106 ibs.
Fraction of
Dispersion: 0.26
Release Rate (million Ibs/yr): 29.4
Consumption: 106.1 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LDso
Dosage
2460 mg/kg
2140mg/kg
890 mg/kg
1340 mg/kg
950 mg/kg
3570 mg/kg
Animal
rat
rat
rabbit
rabbit
guinea pig
human
Non-lethal Acute Effects:
Aplastic anemia
2000 ppm (4 hours)
25 ppm
rat
human (CNS)
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
Route
oral
intravenous.
oral
skin
oral
oral
inhalation
inhalation
AIII-147
-------
Methyl acetate
CHEMICAL NAME
CAS Number: 79-20-9
Chemical Name: Acetic acid, methyl ester
Synonyms: Methyl acetate
Molecular
Formula: C3H6O2
O
-~" II
Structure: CH3 - C - O - CH3
Chemical Properties
Molecular Weight: 74.08 Physical State: Liquid
Vapor Pressure: 212.5 mm at 25°C Vapor Density: 2.55
Boiling Point: 57.8°C Melting Point: -98.1°C
Density: 0.9330 at 20°C/4°C Solubility: Very soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire: dangerous
. . Explosion: moderate
AIII-148
-------
Methyl acetate
PRODUCTION DATA
Annual U.S.
Production: 8.8 x 10 ibs. (1966) Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 3700 mg/kg rabbit oral
LDLo 4800 mg/kg rat oral
3000 mg/kg rat subcutaneous
3000 mg/kg guinea pig subcutaneous
80mg/m (31 minutes) mouse inhalation
67 mg/m (56 minutes) cat inhalation
Non-lethal Acute Effects:
Narcotic
Irritant to eyes and mucous membranes (10,000 ppm)
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 200 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 200 ppm
Other Chronic Effects:
AIII-149
-------
Methyl acetoacetate
CHEMICAL NAME
CAS Number: 105-45-3
Chemical Name: Acetoacetic acid, methyl ester
Synonyms: Methyl acetylacetonate
Molecular
Formula: CSH8O3
O
Structure: CH3 - C - CH2 - C - O CH3
Chemical Properties
Molecular Weight: 116.05
Vapor Pressure: 0.7 mm at 20°C
Boiling Point: 171.7°C
Density: 1.0785 at 20°C/20°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: -31.9°C
Solubility: Slightly (H2O)
AIII-150
-------
Methyl acetoacetate
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 3000 mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-151
-------
Methylal
CHEMICAL NAME
CAS Number: 109-87-5
Chemical Name: Dimethoxy me thane
Synonyms: Formal Methylal
Methylene dimethyl ether Formaldehyde dimethyl acetal
Molecular
Formula: C3H8O2
H
I
Structure: H3C - O - C - O -
Chemical Properties
Molecular Weight: 76.1 Physical State: Liquid
Vapor Pressure: 330 mm at 20°C Vapor Density: 2.63
Boiling Point: 45.5°C at 760mm Melting Point: -104.8°C
Density: 0.8593 at 20°C/4°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-dangerous
Explosion-moderate
AIII-152
-------
Methylal
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDL0 3013mg/kg guinea pig subcutaneous
Non-lethal Acute Effects:
Injury to lungs, kidney, liver and heart
Narcotic in high concentration
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 1000 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 1000 ppm
Other Chronic Effects:
AI11-153
-------
Methyl alcohol
CHEMICAL NAME
CAS Number: 67-56-1
Chemical Name: Methanol
Synonyms: Methyl alcohol
Carbinol
Methyl hydroxide
Molecular
Formula: CH4O
Structure: CHjOH
Chemical Properties
Molecular Weight: 32.04
Vapor Pressure: 127.9 mm at 25°C
Boiling Point: 64.8°C
Density: 0.7913at20°C/4°C
Octanol/Water Parti-
tion Coefficient: ,
Environmental Persistence
BOD: 95% of theoretical at 20°C for 20 days
Total theoretical oxygen demand = 1.5 gm/gm
Atmospheric Reactivity:
Reacts with oxidizing materials
Safety Hazard: Fire-dangerous
Explosion-moderate
Physical State: Liquid
Vapor Density: 1-11
Melting Point: -93.9°C
Solubility: Infinite (H2O)
AIII-154
-------
Methyl alcohol
PRODUCTION DATA
Annual U.S.
Production:
Fraction of
Dispersion:
5103.5 x 1 (Tibs. (1975)
0.01
Consumption:
Fraction of Pro-
duction Lost: 0.015
Release Rate (million Ibs/yr): 987.7
TOXICITY DATA
Acute Toxicity
LD50
LC
SO
9800 mg/kg
340 mg/kg
1800 mg/kg
420 mg/kg
6300 mg/kg
7000 mg/kg
4750 mg/kg
1000 ppm
Non-lethal Acute Effects:
Eye-irritant, blindness
TDLo
CNS narcotic
TD
Lo
.100 mg/kg
300 ppm
Animal
mouse
human
rat
mouse
dog
donkey
rabbit
monkey
human
human
Route
subcutaneous
oral
intraperitoneal
oral
oral
oral
oral
inhalation
oral
inhalation
Irritant to mucous membranes; drying of skin; dermatitis
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 200 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Conjunctivitis
Headache
Giddyness
Insomnia
Gastric disturbances
Failure of vision-300 ppm
TLV: 200ppm
Odor perception: 5,900 ppm
AIII-155
-------
Methylamine
CHEMICAL NAME
CAS Number: 74-89-5
Chemical Name: Methylamine
Synonyms: Monomethylamine
Aminomethane
Molecular
Formula: CH5N
H
Structure:
H
CH,
Chemical Properties
Molecular Weight: 31.1
Vapor Pressure: 2509 mm at 25°C
Boiling Point: -6.3°C at 760 mm
Density: 0.662 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: -1.00
Physical State: Gas
Vapor Density: 1.07
Melting Point: -93.5°C
Solubility: Very soluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fiie-dangerous
Explosion-moderate
AIII-156
-------
Methylamine
PRODUCTION DATA
Annual U.S.
Production: 319 x 106 Ibs (1976 capacity) Consumption: 185 x 106 Ibs. (1975-all methyl amines)
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LD50
Non-lethal Acute Effects:
Strong irritant
TOXICITY DATA
3000 mg/kg
Animal
mouse
Route
intiaperitoneal
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-157
-------
Methylamyl acetate
CHEMICAL NAME
CAS Number: 108-84-9
Chemical Name: 4-Methyl-2-pentanol, acetate
Synonyms: 4-Methyl-2-pentyl acetate
Acetic acid, 1,3-dimethylbutyl ester
Methylisobutylcarbinol acetate
Molecular
Formula: C8H16O2
CH3 CH3
Structure: CH3 - C - O - CH - CH2 - CH - CH3
Chemical Properties
Molecular Weight: 144.21 Physical State: Liquid
Vapor Pressure: 3. mm at 20°C Vapor Density: 4.97
Boiling Point: 147 to 148°C Melting Point: -63.8°C
Density: 0.8805 at 0°C/0°C Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Fire-moderate
AIII-158
-------
Methylamyl acetate
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
Non-lethal Acute Effects:
Eye irritation:
TOXICITY DATA
Dosage Animal
4000 ppm rat
100 ppm human
Route
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 50 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-159
-------
Methylamyl alcohol
CHEMICAL NAME
CAS Number: 108-11-2
Chemical Name: 4-Methyl-2-pentanol
Synonyms: Methyl isobutyl carbinol
Methyl amyl alcohol
Molecular
Formula: C6H14O
CH.,
OH
Structure: CH3 - CH - CH2 - C - CH3
I
~H
Chemical Properties
Molecular Weight: 102.18
Vapor Pressure: 2.8 ram at 20°C
Boiling Point: 133°C at 760 ram
Density: 0.8075 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 3.53
Melting Point: -90°C (sets)
Solubility: Slightly (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AIII-160
-------
Methylamyl alcohol
PRODUCTION DATA
Annual U.S.
Production: 50 x 106 Ibs.
Fraction of
Dispersion: 0.80
Release Rate (million Ibs/yr): 40.8
Consumption: 50 x 10 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LDso
Dosage
812mg/kg
3560 mg/kg
2600 mg/kg
2000 ppm (4 hours)
Animal
mouse
rabbit
rat
rat
Route
intraperitoneal
skin
oral
inhalation
Non-lethal Acute Effects:
Local irritant
Anesthetic in high concentrations
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 25 ppm (skin)
Carcinogenicity:
Mutagenicity:
Teratoganicity:
Other Chronic Effects:
TLV:
AIII-161
-------
Methylaniline
CHEMICAL NAME
CAS Number: 100-61-8
Chemical Name: N-Methyl aniline
Synonyms: Monomethyl aniline
Methyl phenylamine
Molecular
Formula: C7H9N
~H CHL
\ /
Structure:
Chemical Properties
Molecular Weight: 107.15 Physical State: Liquid
Vapor Pressure: 1 mm at 36°C Vapor Density: 3-70
Boiling Point: 196.25°C at 760 mm Melting Point: -57°C
Density: 0.98912 at 20°C/4°C Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient: 1.82
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Disaster hazard-dangerous-toxic fumes-aniline
AIII-162
-------
Methylaniline
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: . auction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 24 mg/kg cat intravenous
280 rag/kg rabbit oral
24 mg/kg rabbit intravenous
1200 mg/kg guinea pig oral
1200 mg/kg guinea pig subcutaneous
Non-lethal Acute Effects:
Allergen
Hemorrhage in bladder
Nervous disorders
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 2 ppm
Carcinogenicity: Carcinogen
Neoplastic Effects:
TDLo 380 mg/kg (28 weeks) mouse oral
Mutagenicity:
Teratogenicity: TLV: 2 ppm (skin)
Other Chronic Effects:
AIII-163
-------
Methylbenzyl alcohol
CHEMICAL NAME
CAS Number: 98-85-1
Chemical Name: o-Methylbenzyl alcohol
Synonyms: Methyl phenyl caibinol Styialyl alcohol
Phenyl methyl caibinol 1-Phenyl ethanol
Molecular
Formula: C8H10O
OH
I
Structure: / V "cf-CH~
H
Chemical Properties
Molecular Weight: 122.16 Physical State: Liquid
Vapor Pressure: 0.25 mm at 25°C Vapor Density: 4.21
Boiling Point: 203°C at 760 mm Melting Point: 20.7°C
Density: 1.0129 at 20°C/4°C Solubility: Slightly soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
AIII-164
-------
Methy(benzyl alcohol
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 400mg/kg rat oral
2500 mg/kg rabbit skin
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-165
-------
Methyl bromide
CHEMICAL NAME
CAS Number: 74-83-9
Chemical Name: Bromomethane
Synonyms: Methyl bromide
Molecular
Formula: CH3Br
Structure:
H
]__
H-C-Br
J_
H
Chemical Properties
Molecular Weight: 94.95
Vapor Pressure: 1370mmat25°C
Boiling Point: 3.56°C at 760 mm
Density: 1.6755 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Fire-moderate
Explosion—moderate
Disaster hazard-dangerous-toxic fumes-bromides
Physical State: Volatile liquid or gas
Vapor Density: 3.72
Melting Point: -93.6°C
Solubility: Slightly (13.4 gm/1) (H2O)
AIII-166
-------
Methyl bromide
PRODUCTION DATA
Annual U.S. "
Production: 24.6 x 106 ibs. (1972)
Fraction of
Dispersion: 0.90
Release Rate (million Ibs/yr): 22.4
Consumption: 24.6 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.01
TOXICITY DATA
Acute Toxicity
LC50
21 mg/1
514 ppm (6 hours)
6425 ppm (1 hour)
300 ppm (9 hours)
Non-lethal Acute Effects:
Irritate of eyes, skin, and mucous membranes
Damage to liver and kidney
CNSeffects
Animal
rat
rat
rabbit
guinea pig
TCLo
Skin effects
TCLo
35 ppm
8000 ppm
human
human
Chronic Toxicity
U.S. Occupational Standard: (air) Ceiling 20 ppm (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 20 ppm
Nausea, vomiting, headache after 35 ppm for two weeks
Severe lung iritation
Route
inhalation
inhalation
inhalation
inhalation
inhalation
skin
AIII-167
-------
Methyl butyl ketone
CHEMICAL NAME
CAS Number: 591-78-6
Chemical Name: Methyl n-butyl ketone
Synonyms: 2-Hexanone
n-Butyl methyl ketone
Molecular
Formula: C6H12O
O
Structure: CH3 - C - CH2CH2CH2CH3
Chemical Properties
Molecular Weight: 100.16
Vapor Pressure: 10 mm at 38.8°C
Boiling Point: 128°C at 760 mm
Density: 0.81127 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 1.38
Physical State: Liquid
Vapor Density: 3.45
Melting Point: -57°C
Solubility: Slightly (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
Explosion-moderate
AIII-168
-------
Methyl butyl ketone
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LD50
Dosage
2590 mg/kg
914 mg/kg
914 mg/kg
6000 ppm (7 hours)
Animal
rat
rat
guinea pig
guinea pig
Route
oral
intraperitoneal
oral
inhalation
Non-lethal Acute Effects:
Irritant to eyes and respiratory tract
CNS depressant
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-169
-------
Methylbutynol
CHEMICAL NAME
CAS Number: 115-19-5
Chemical Name: 2-Methyl-3-butyn-2-ol
Synonyms: Methyl butynol
l,l-Dimethyl-2-propynol
Ethynyldimethylcaibinol
Molecular
Formula: C5H8O
Structure:
OH
I
- C - C==CH
|
CH~,
Chemical Properties
Molecular Weight: 84.13
Vapor Pressure:
Boiling Point: 104°C at 760mm
Density: 0.8618 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Fire-moderate
Physical State: Liquid
Vapor Density:
Melting Point: 3.0°C
Solubility: Soluble (H2O)
AIII-170
-------
Methylbutynol
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
LD50
TOXICITY DATA
Dosage Animal
3600 mg/kg mouse
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
Route
intraperitoneal
AI11-171
-------
Methyl cellulose
CHEMICAL NAME
CAS Number: 9004-67-5
Chemical Name: Methyl ether cellulose
Synonyms:
Molecular
Formula:
Methyl cellulose
Cellulose methyl ether
Methocel
Structure:
Chemical Properties
Molecular Weight: 40,000-180,000
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
_J n
Physical State: Solid
Vapor Density:
Melting Point:
Solubility: Soluble (H2O)
AIII-172
-------
Methyl cellulose
PRODUCTION DATA
Annual U.S.
Production: 20 x 106 Ibs. Consumption: 13 x 106 Ibs.
Fraction of Fraction of Pro-
Dispersion: 1-0 duction Lost: 0.03
Release Rate (million Ibs/yr): 13.6
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-173
-------
Methyl chloride
CHEMICAL NAME
CAS Number: 74-87-3
Chemical Name: Chloromethane
Synonyms: Methyl chloride
Molecular
Formula: CH3G1
Structure:
H
I
H - cf- a
i
H
Chemical Properties
Molecular Weight: 50.49
Vapor Pressure: 2.83 atm at 25°C
Boiling Point: -24.2°C at 760'mm
Density: 0.9159 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Reacts with oxidizing materials
Reacts slowly with RC^ and O,
tl with OH = 1 year
Safety Hazard: Fire-dangerous
Explosion—moderate
Disaster hazard—dangerous—toxic fumes-chlorides
Physical State: Gas
Vapor Density: 1.78
Melting Point: -97.73°C
Solubility: Soluble (4.9 gm/1 H2O)
AIII-174
-------
Methyl chloride
PRODUCTION DATA
Annual U.S.
Production: 458 x 106 Ibs. (1974)
Fraction of
Dispersion: 0.03
Release Rats (million Ibs/yr): 18.1
Consumption: 312 x 10° Ibs. (1975)
Fraction of Pro-
duction Lost: 0.01
TOXIGITY DATA
Acute Toxicity
LDSO
1800mg/kg
3000 ppm (4 hours)
3146 ppm (7 hours)
20,000 ppm (2 hours)
Animal
rat
rat
mouse.
guinea pig
Route
oral
inhalation
inhalation
inhalation
Non-lethal Acute Effects:
Slight irritant
Narcotic
CNS damage
Damage to bone, liver, kidney, and cardiovascular system
Pulmonary edema
Conjunctivitis
Anemia '.
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Ceiling 200 ppm
Peak 300 ppm/5 min/3 hours
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 100 ppm
AIII-175
-------
Methylcholanthrene
CHEMICAL NAME
CAS Number: 56-49-5
Chemical Name: 3-Methyl cholanthrene
Synonyms:
Molecular
Formula:
20-Methylcholanthrene
1,2-Dihydro-3-methy lbenz(j) aceanthrylene
Structure:
Chemical Properties
Molecular Weight: 268.3
Vapor Pressure:
Boiling Point: 280°C at 80 mm
Density: 1.28 at 20°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State:
Vapor Density:
Melting Point:
Solubility:
Solid
AIII-176
-------
Methylcholanthrene
PRODUCTION DATA
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr)
Acute Toxicity
LDLo
Chronic Toxicity
TOXICITY
Dosage
100 mg/kg
11 mg/kg
Consumption:
Fraction of Pro-
duction Lost:
DATA
Animal
mouse
frog
Route
intraperitoneal
intrarenal
U.S. Occupational Standard:
Carcinogenicity:
TDLo
Neoplasm TOLO
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
280 mg/kg
18 mg/kg
3 mg/kg
100 mg/kg (5 weeks)
800 Mg/kg
13 mg/kg (4 2 weeks)
31 2 Mg/kg
120 mg/kg
132 mg/kg (12 weeks)
4 mg/kg
40 mg/kg (15 days)
58 mg/kg
4500 mg/kg (8 weeks)
27 mg/kg
34mg/kg (25 weeks)
39 mg/kg (6 days)
1600 mg/kg (20 weeks)
40 mg/kg
100 mg/kg (9 weeks)
3320 mg/kg (40 weeks)
rat
rat
rat
rat
rat
mouse
mouse
mouse
rabbit
guinea pig
guinea pig
hamster
chicken
duck
rat
rat
mouse
dog
rabbit
hamster
TLV:
oral
subcutaneous
parenteral
intratracheal
implant
skin
subcutaneous
intratracheal
intratracheal
intraperitoneal
subcutaneous
implant
intraperitoneal
intratracheal
skin
intravenous
intraperitoneal
implant
implant
skin
AIII-177
-------
Methylcyclohexane
CHEMICAL NAME
CAS Number: 108-87-2
Chemical Name: Methylcyclohexane
Synonyms: Hexahydrotoluene
Cyclohexylmethane
Molecular
Formula: C7H14
Structure:
CH-,
Chemical Properties
Molecular Weight: 98.19
Vapor Pressure: 47.06 mm at 25°C
Boiling Point: 100.9°C at 760 mm
Density: 0.7694 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard: Fire-dangerous
Explosion—moderate
Physical State: Liquid
Vapor Density: 3.39
Melting Point: -126.59°C
Solubility: Insoluble (H2O)
AIII-178
-------
Methylcyclohexane
PRODUCTION DATA
Annual U.S.
Production: • Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDLo 4000 rag/kg rabbit oral
LCSo 7500 ppm (70 minutes) rabbit inhalation
Non-lethal Acute Effects:
Irritates skin
Narcosis and anesthesia
Chronic Toxicity
U.S. Occupational Standard: (air) TWA SOO ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 500 ppm
Other Chronic Effects:
AIII-179
-------
Methylcyclohexanol
CHEMICAL NAME
CAS Number: 25639-42-3
Chemical Name: Methylcyclohexanol
Synonyms:
Molecular
Formula:
4-Methyl cyclohexanol
Hexahy drome thy 1 phenol
Hexahydio cresol
C7H14O
Structure:
Chemical Properties
Molecular Weight: 114.19
Vapor Pressure:
-------
Methylcyclohexanol
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDLo 1750 mg/kg rabbit oral
Non-lethal Acute Effects:
Irritant to eyes and trachea
Leucopenia
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 100 ppm
Other Chronic Effects:
AIII-181
-------
Methyl cyclohexanone
CHEMICAL NAME
CAS Number: 583-60-8
Chemical Name: 2-Methyl cyclohexanone
Synonyms:
Molecular
Formula: C7HnO
O
Structure:
CH,
Chemical Properties
Molecular Weight: 112.17
Vapor Pressure: <5 mm at 25°C
Boiling Point: 165°C at 757 mm
Density: 0.9250 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Fire-moderate
Physical State: Liquid
Vapor Density: 3.86
Melting Point: -13.9°C
Solubility: Insoluble (H2O)
AIII-182
-------
Methylcyclohexanone
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute toxicity Dosage Animal Route
LD50 2140mg/kg rat oral
LDLo lOOOmg/kg rabbit oral
Non-lethal Acute Effects:
Local irritant
Damage to liver and kidney
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 100 ppm
Other Chronic Effects:
AIII-183
-------
4,4-Methylenebis(2-chloroaniline)
CHEMICAL NAME
CAS Number: 101-14-4
Chemical Name: 4,4'-Methylenebis[2-chloro benzenamine]
Synonyms:
Molecular
Formula:
4,4'-Methylene-bis(2 chloroaniline)
Bisamine
Diamino-3-chlorophenyl-me thane
Cyanaset
Dacpm
Curalin
Structure:
Chemical Properties
Molecular Weight: 267.16
Vap or Pressu re: Negligible
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Solid
Vapor Density:
Melting Point: 104tol07°C
Solubility:
All1-184
-------
4,4-Methylenebis(2-chloroaniline)
PRODUCTION DATA
Annual U.S.
Production: 7.716 x 106 Ibs. (1972) Consumption:
Fraction of Fraction of Pro-
Dispersion: 0.01 duction Lost: 0.015
Release Rate (million Ibs/yr): 0.1
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
TDLo 420 gm/kg (80 weeks) rat oral
2SOO mg/kg (88 weeks) rat subcutaneous
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-185
-------
Methylene chloride
CHEMICAL NAME
CAS Number: 75-09-2
Chemical Name: Dichloromethane
Synonyms: Methylene chloride
Methylene dichloiide
Molecular
Formula: CH2C12
Cl
J
Structure: H - C - Cl
I
H
Chemical Properties
Molecular Weight: 84.93 Physical State: Liquid
Vapor Pressure: 435.8 ram at 25°C Vapor Density: 2.93
Boiling Point: 40°C at 760 mm Melting Point: -95.1°C
Density: 1.3266 at 20°C/4°C Solubility: Slightly (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD: Total theoretical oxygen demand-0.38 gm/gm
Atmospheric Reactivity:
Not very active towards 03 and
tvi = 1 year with OH
Safety Hazard: Explosion-minor
Disaster hazard-dangerous-toxic fumes-phosgene
AIII-186
-------
Methylene chloride
PRODUCTION DATA
Annual U.S.
Production: 591 x 106 Ibs. (1974)
Fraction of
Dispersion: °-95
Release Rate (million Ibs/yr): 366.8
Consumption: Estimated as 110 to 120 x 10 Ibs.
(1975)
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
LD10o
Dosage
2136mg/kg
1500 mg/kg
6460 mg/kg
950 mg/kg
1900 mg/kg
3000 mg/kg
2700 mg/kg
200 mg/kg
2700 mg/kg
5000 ppm (2 hours)
Animal
rat ',
mouse
mouse
dog
rabbit
dog
dog
dog
rabbit
guinea pig
Route
oral
intraperitoneal
subcutaneous
intraperitoneal
oral
oral
subcutaneous
intravenous
subcutaneous
inhalation
Non-lethal Acute Effects:
Central nervous system effects: narcosis
TCLo 500 ppm (1 year) intermittent
Blood effects:
TCLo 500 ppm (8 hours)
Chronic Toxicity
U.S. Occupational Standard: (air) TWA
Ceiling
Peak
Carcinogenicjty:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Dermatitis
Liver damage
Reduced growth size
500 ppm
1000 ppm
2000 ppm/5 minutes/2 hours
TLV: 500ppm
AIII-187
-------
Methylenedianiline
CHEMICAL NAME
CAS Number: 101-77-9
Chemical Name: 4,4'-Methylenedianiline
Synonyms: Methylenedianiline
Molecular
Formula: C13Hi4N2
Structure:
NH
Chemical Properties
Molecular Weight: 198.3
Vapor Pressure: <10 mm at 25°C
Boiling Point:
Density: . .
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard: Disaster hazard-dangerous-toxic fumes-aniline
Physical State: Solid
Vapor Density:
Melting Point: 90°C
Solubility:
AIII-188
-------
Methylenedianiline
Annual U.S.
Production: 2.205 x 106 Ibs.
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost: °-015
Acute Toxicity
LDso
TOXICITY DATA
Dosage Animal
347 mg/kg rat
280 mg/kg rat
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Carcinogen:
TDLo
Neoplasm:
TDLo
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
80 mg/kg
1410 mg/kg
Route
oral
subcutaneous
rat
rat
TLV:
oral
subcutaneous
AIII-189
-------
Methyldioxolane
CHEMICAL NAME
CAS Number: 1331-09-5
Chemical Name: Methyl dioxolane
Synonyms: 2-Methyl-3-dioxolane
Molecular
Formula: C4H8O2
Structure:
Chemical Properties
Molecular Weight: 88.12 Physical State: Liquid
Vapor Pressure: Vapor Density: 3.03
Boiling Point: 81 to82°Cat 760mm Melting Point:
Density: 0.9811 at 20°C/4°C Solubility: Very soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AIII-190
-------
M ethyl dioxolane
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 3000mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AI11-191
-------
Methyl ethyl ketone
CHEMICAL NAME
CAS Number: 78-93-3
Chemical Name: 2-Butanone
Synonyms: Methyl ethyl ketone
Methyl acetone
Molecular
Formula: C4H8O
O
II
Structure: CH3 - C - CH2 - CH3
Chemical Properties
Molecular Weight: 72.12 Physical State: Liquid
Vapor Pressure: 96.4 mm at 25°C Vapor Density: 2.41
Boiling Point: 79.6°C at 760 mm Melting Point: -86.35°C
Density: 0.8054 at 20°C/4°C Solubility: Very soluble (H2O)
Octanol/Water Parti-
tion Coefficient: 0.29
Environmental Persistence '
BOD: 89% of theoretical after 20 days at 20°C -
Total theoretical oxygen demand 2.44 gm/gm
Atmospheric Reactivity:
Reacts with oxidizing materials
Safety Hazard: Fire-dangerous
Explosion-moderate
AIII-192
-------
Methyl ethyl ketone
PRODUCTION DATA
Annual U.S.
Production: 509 x 106 Ibs.
Fraction of
Dispersion: 0.95
Release Rate (million Ibs/yr): 524.7
Consumption: 544.3 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LD50
TOXICITY DATA
Animal
rat
mouse
rat
rat
3400 mg/kg
616 mg/kg
2000 mg/kg
2000 ppm (4 hours)
Non-lethal Acute Effects:
Local irritation and narcosis
Numbness of fingers and arms: 300 to 600 ppm
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 200 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Local irritation and narcosis
Route
oral
intraperitoneal
intraperitoneal
inhalation
TLV: 200 ppm
Odor perception: 25 ppm
AIII-193
-------
Methyl formate
CHEMICAL NAME
CAS Number: 107-31-3
Chemical Name: Formic acid, methyl ester
Synonyms: Methyl methanoate
Methyl formate
Molecular
Formula: C2H4O2
O
Structure: H - C - O - CH,
Chemical Properties
Molecular Weight: 60.05
Vapor Pressure: 602.5 mm at 25°C
Boiling Point: 32.0°C
Density: 0.975 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 2.07
Melting Point: -99°C
Solubility: Very soluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-dangerous
Explosion -moderate
Disaster hazard-dangerous-toxic fumes
AIII-194
-------
Methyl formate
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
Dosage
1620 mg/kg
10,000 ppm
Animal
rabbit
guinea pig
Route
oral
inhalation
Non-lethal Acute Effects:
Irritation of conjunctivia and optic nerve
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 100ppm
AIII-195
-------
Methylhydrazine
CHEMICAL NAME
CAS Number: 60-34-4
Chemical Name: Methylhydrazine
Synonyms: Monomethylhydiazine
Molecular
Formula: CH6N
Structure:
N - N
H3C
Chemical Properties
Molecular Weight: 46.07
Vapor Pressure: 49.6 mm at 25°C
Boiling Point: 87°C at 745 mm
Density: 0.874 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density: 1.6
Melting Point: <-80°C
Solubility: Soluble (H2O)
AIII-196
-------
Methyl hydrazine
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LCSO
Dosage
183mg/kg
21 mg/kg
17 mg/kg
33 mg/kg
33 mg/kg ,
96 mg/kg
12 mg/kg
49 mg/kg
22 mg/kg
239 mg/kg
21 mg/kg
74 ppm (4 hours)
56 ppm (4 hours)
96 ppm (1 houi)
82 ppm (1 hour)
143 ppm (4 hours)
Animal
rat
rat
rat
rat
mouse
rabbit
rabbit
guinea pig
hamster
hamster
hamster
rat
mouse
dog
monkey
hamster
Chronic Toxicity
U.S. Occupational Standard: (air) 0.2 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Ceiling 350 /ig/m (skin)
3000 mg/kg (47 weeks) hamster
TD
Lo
Other Chronic Effects:
TLV:
100 mg/kg (8-12 days) mouse
200 mg/kg (14 days) rabbit
Route
skin
intraperitoneal
intravenous
oral
oral
skin
intravenous
skin
oral
skin
intraperitoneal
inhalation
inhalation
inhalation
inhalation
skin
oral
oral
oral
AIII-197
-------
Methyl iodide
CHEMICAL NAME
CAS Number: 74-88-4
Chemical Name: lodomethane
Synonyms: Methyliodide
Molecular
Formula: CH3I
Structure:
H
I
H-C-I
l_
H
Chemical Properties
Molecular Weight: 141.94
Vapor Pressure: 400 mm at 25.3°C
Boiling Point: 42.4°C at 760 mm
Density: 2.279 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 1.80
Environmental Persistence
BOD:
Atmospheric Reactivity:
Residence in atmosphere: 0.003 year
Safety Hazard: Disaster hazard-dangerous-toxic fumes-iodides
Physical State: Liquid
Vapor Density: 4.89
Melting Point: -66.45°C
Solubility: Slightly (H2O)
AIII-198
-------
Methyl iodide
Annual U.S.
Production:
Fraction of
Dispersion:'
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
Animal
rat
mouse
rat
426 mg/m3 (24 hours) mouse
220 mg/kg
HOmg/kg
800 mg/kg
Non-lethal Acute Effects:
Strong narcotic and anaesthetic
Irritant
Nausea and vomiting
Chronic Toxicity
U.S. Occupational Standard: (aii) TWA 5 ppm (skin)
Carcinogenicity:
Neoplasm TDi_,0
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
50 mg/kg
rat
TLV:
Route
oral
subcutaneous
skin
inhalation
subcutaneous
AIII-199
-------
Methyl isoamyl ketone
CHEMICAL NAME
CAS Number: 110-12-3
Chemical Name: S-Methyl-2-hexanone
Synonyms: Methyl iso-amyl ketone
MIAR
Molecular
Formula: C7Hi4O
O CH,
II I J
Structure: CH3 - C - CH2 - CH2 - CH
I
CH,
Chemical Properties
Molecular Weight: 114.19
Vapor Pressure:
Boiling Point: 144°C at 760 mm
Density: 0.888 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility: Slightly (H2O)
AIII-200
-------
Methyl isoamyl ketone
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDso
LDLo
LCLo
Dosage
4760 mg/kg
3200 mg/kg
2000 ppm (4 hours)
Animal
rat
mouse
rat
Route
oral
oral
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-201
-------
Methyl isobutyl ketone
CHEMICAL NAME
CAS Number: 108-10-1
Chemical Name: 4-Methyl-2-pentanone
Synonyms: Methyl isobutyl ketone
Isobutyl methyl ketone
Hexone
Molecular
Formula: C6H12O
Isopropylacetone
MIBK
Structure:
CH - CH2 - C
CH0
O
CH,
Chemical Properties
Molecular Weight: 100.16
Vapor Pressure: 7.1 mm at 25°C
Boiling Point: 116.85°C at 760mm
Density: 0.7978 at 20°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD: 69% of theoretical after 20 days at 20°C
Total theoretical oxygen demand = 2.7 gm/gm
Atmospheric Reactivity:
Reacts vigorously with reducing materials
Safety Hazard: Fire-moderate
Physical State: Liquid
Vapor Density: 3.45
Melting Point: -84.7°C
Solubility: Slightly (H2O)
AIII-202
-------
Methyl isobutyl ketone
PRODUCTION DATA
Annual U.S.
Production: 208.3 x 106 Ibs.
Fraction of
Dispersion: 0.95
Release Rate (million Ibs/yr): 201.0
Consumption: 208.3 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.0 IS
Acute Toxicity
LDSO
LCLo
Non-lethal Acute Effects:
Irritation effects
TCLo
TOXICITY DATA
Dosage Animal
268 mg/kg mouse
2080 mg/kg rat •
2850 mg/kg mouse
4000 ppm (15 minutes) rat
200 ppm
human
Route
intraperitoneal
oral
oral
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Carcinogenicity:
Mutagehicity:
Teratogenicity:
Other Chronic Effects:
TLV: 100 ppm
Odor perception: 8 ppm
AIII-203
-------
Methyl isocyanate
CHEMICAL NAME
CAS Number: 624-83-9
Chemical Name: Isocyanic acid, methyl estei
Synonyms:
Molecular
Formula:
Methyl isocyanate
Methyl carbylamine
C2H3NO
Structure: CH3 - N = C = O
Chemical Properties
Molecular Weight: 57.05
Vapor Pressure:
Boiling Point: 59.6°C
Density: 0.9230 at 27°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: -45° C
Solubility: Soluble (H2O)
Reacts with H2O
AI11-204
-------
Methyl isocyanate
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXlCITY DATA
Acute Toxicity
LCSO
Non-lethal Acute Effects:
Pulmonary edema
TCLo
Dosage
14 ppm (4 hours)
10 ppm (4 hours)
8 ppm (4 hours)
13 ppm (4 hours)
0.5 ppm
Animal
rat
mouse
rabbit
guinea pig
human
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 0.02 ppm (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
Route
inhalation
inhalation
inhalation
inhalation
inhalation
AIII-205
-------
Methyl mercaptan
CHEMICAL NAME
CAS Number: 74-93-1
Chemical Name: Methanethiol
Synonyms: Methyl mercaptan
Molecular
Formula: CH4S
Structure:
H
I
H-C-S-H
I
H
Chemical Properties
Molecular Weight: 48.11
Vapor Pressure: 760 mm at 6.8°C
Boiling Point: 6.2°C
Density: 0.8665 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid 01 gas
Vapor Density: 1.66
Melting Point: -123°C
Solubility: Slightly (H20)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-dangerous
Disaster hazard-dangerous-toxic fumes-SOx
AIII-206
-------
Methyl mercaptan
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 2.4 mg/kg mouse subcutaneous
LCLo 10,000 ppm rat inhalation
Non-lethal Acute Effects:
Irritant
Chronic Toxicity
U.S. Occupational Standard: (air) Ceiling 10 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 0.5 ppm
Other Chronic Effects:
AIII-207
-------
Methyl methacrylate
CHEMICAL NAME
CAS Number: 80-62-6
Chemical Name: Methacrylic acid, methyl ester
Synonyms: Methyl methaciylate
2-Methyl propenoic add, methyl ester
Molecular
Formula: C5H8O2
CHUO
_l II
Structure: CH2 = C - C - OCH3
Chemical Properties
Molecular Weight: 100.13 Physical State: Liquid
Vapor Pressure: 40 mm at 25.5°C Vapor Density: 3.45
Boiling Point: 100 to 101°Cat 760mm Melting Point: -48°C
Density: 0.9440 at 20°C/4°C Solubility: Slightly (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
Explosion—moderate
AIII-208
-------
Methyl methacrylate
PRODUCTION DATA
Annual U.S.
Production: 718.8 x 106 Ibs. (1974)
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Consumption: 625 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
LC50
Non-lethal Acute Effects:
Irritant effect
Dosage
7500 mg/kg
1000 mg/kg
6300 mg/kg
4500 mg/kg
6300 mg/kg
2000 mg/kg
6300 mg/kg
1800 mg/kg
5000 mg/kg
6550 mg/kg
3750 ppm
Animal
rat
mouse
mouse
dog
guinea pig
guinea pig
guinea pig
rat
dog
rabbit
rat
TC
.
Lo
'. 125 ppm
Central nervous system effects
TC
Lo
150 mg/mj
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
human
human
Route
subcutaneous
intraperitoneal
subcutaneous
subcutaneous
oral
intraperitoneal
subcutaneous
intraperitoneal
oral
oral
inhalation
inhalation
inhalation
TLV: 100 ppm
AIII-209
-------
Methylnaphthalene
CHEMICAL NAME
CAS Number: 1321-944
Chemical Name: Methylnaphthalene
Synonyms: 1-Methyl naphthalene
Molecular
Formula:
CH,
Structure:
Chemical Properties
Molecular Weight: 142.21
Vapor Pressure: <10 mm at 25°C
Boiling Point: 244.64°C at 760 mm
Density: 1.0202 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: -22°C
Solubility: Insoluble (H2O)
AIII-210
-------
Methyl naphthalene
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 5000mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-211
-------
N-Methyl-N-nitro-N-nitrosoguanidine
CHEMICAL NAME
CAS Number: 70-25-7
Chemical Name: l-MethyI-3-nitro-l-nitrosoguanidine
Synonyms: N-Methyl-N'-nitio-nitrosoguanidihe
N'-Nitro-N-nitroso-N-methylguanidine
Molecular
Formula: C2HSNSO3
O
N NH H
\ II /
Structure: N - C - N
/ \
H,C NO,
Chemical Properties
Molecular Weight: 147.1
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State:
Vapor Density:
Melting Point:
Solubility:
AIII-212
-------
N-Methyl-N-nitro-N-nitrosoguanidine
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDLo
Dosage _
400 mg/kg
Animal
rat
Route
oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
75 mg/kg (4 weeks)
40 mg/kg (4 weeks)
40 mg/kg (10 weeks)
200 mg/kg (32 days)
100 mg/kg
200 mg/kg (22 weeks)
48 mg/kg
2457 mg/kg (66 weeks)
740 mg/kg (2.7 weeks)
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
rat
rat
rat
rat
mouse
mouse
mouse
dog
hamster
TLV:
oral
intiaperitoneal
subcutaneous
rectal
oral
skin
subcutaneous
oral
oral
AIII-213
-------
Methyl parathion
CHEMICAL NAME
CAS Number: 298-00-0
Chemical Name: O,O-Dimethyl phosphorothioic acid O-{p-nitrophenyl) ester
Synonyms: Methyl parathion
O,O-Dimethyl-O-p-nitrophenyl phosphorothioate
Molecular
Formula: C8Hi0NO5PS
OCH,
I J
Structure: S = P - O
I
OCH,
Chemical Properties
Molecular Weight: 263.20
Vapor Pressure: 0.97 mm at 20°C
Boiling Point: Decomposes
Density: 1.358 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 1.44
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Explosion-commercial product decomposes at 120 C with violence
Physical State: Solid
Vapor Density:
Melting Point: 35-36°C
Solubility: Slightly soluble (55 to 60 ppm H2O)
AIII-214
-------
Methyl parathion
PRODUCTION DATA
Annual U.S.
Production: 51.1 x 106 Ibs.
Fraction of
Dispersion: Estimated as 1.0
Release Rate (million Ibs/yr): 52.7
Consumption: 52.2 x 10 Ibs.
Fraction of Pro-
duction Lost: °-01
TOXICITY DATA
Acute Toxicity
9 mg/kg
67 mg/kg
3500 mg/kg
23 mg/kg
9300 mg/kg
30 mg/kg
300 mg/kg
7 mg/kg
25 mg/kg
Animal
rat
rat
rat
mouse
mouse
mouse
rabbit
wild bird
mammal
Route
oral
skin
intraperitoneal
intraperitoneal
intraperitoneal
subcutaneous
skin
oral
unreported
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 200 ng/m3
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-215
-------
M ethyl pentanediol
CHEMICAL NAME
CAS Number: 10741-5
Chemical Name: 2-Methyl-2,4-pentanediol
Synonyms: 2,4-Dihydroxy-2-methylpentane
a A^'-Trimethyltrimethylene glycol
Molecular
Formula: C6H14O2
H CH3
I I
Structure: CH, - C - CH, - C - CH,
J , L , 3
OH OH
Chemical Properties
Molecular Weight: 118.06
Vapor Pressure: <0.1 mm at 20°C
Boiling Point: 198°C
Density:
Octanol/Water Parti-
tion Coefficient: -0.14
Environmental Persistence
BOD: 90% of theoretical after 20 days at 20°C
Total theoretical oxygen demand-2.3 (gm/gm)
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point: -50°C
Solubility: Infinite (H2O)
AIII-216
-------
Methyl pentanediol
PRODUCTION DATA
Annual U.S.
Production: SO x 106 Ibs.
Fraction of
Dispersion: 1.0
Release Rate (million Ibs/yr): 50.1
Consumption: 50 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LDso
Dosage
3696 mg/kg
3860 mg/kg
1299 mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
mouse
mouse
Route
oral
oral
intiaperitoneal
TLV:
AIII-217
-------
Methylpentynol
CHEMICAL NAME
CAS Number: n-15-8
Chemical Name: 3-Methyl-l-pentyn-3-ol
Synonyms: Methyl pentynol
2-Ethynyl-2-butanol
Dormison
Molecular
Formula: C6H10O
CH3
Structure: HjC - CH~2 - C - C =
__
off
Chemical Properties.
Molecular Weight: 98-15 Physical State: Liquid
Vapor Pressure: Vapor Density: 3.38
Boiling Point: 120 to 121°C Melting Point: 30 to 31°C
Density: 0.8688 at 20°C/4°C Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient: 1.80
Environmental Persistence
BOD:
Atmospheric Reactivity: Reactive toward oxidizing materials
Safety Hazard: Fire-slight
AIII-218
-------
M ethyl pentynol
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LD50
300 mg/kg
698 mg/kg
750 mg/kg
5 34 mg/kg
Non-lethal Acute Effects:
Psychotropic effects:
TDLo 7 mg/kg
Central nervous system effects:
TDLo 70 mg/kg
Dermatitis
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
mouse
mouse
guinea pig
human
human
Route
oral
oral
subcutaneous
oral
oral
oral
TLV:
AIII-219
-------
Methylphenylcarbinol
CHEMICAL NAME
CAS Number: 98-85-1
Chemical Name: a-Methylbenzenemethanol
Synonyms:
Molecular
Formula:
Styralyl alcohol
Phenylmethylcarbinol
1-Phenethyl alcohol
C8H100
OH
I
Structure: CH3 - CH
Chemical Properties
Molecular Weight: 122.17
Vapor Pressure:
Boiling Point: 204°C at 760 mm
Density: 1.0135 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
1-Phenylethanol
a-Methylbenzyl alcohol
Physical State: Liquid
Vapor Density:
Melting Point: 20.7°C
Solubility: Insoluble (H2O)
AIII-220
-------
M ethylpheny Icarbinol
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
*
Teratogenicity: TLV:
Other Chronic Effects:
AI11-221
-------
a-Methyl sty rene
CHEMICAL NAME
CAS Number: 1319-73-9
Chemical Name: Methyl styrene
Synonyms:
a-Methyl styrene
Isopropenyl benzene
a-Phenyl propylene
Molecular
Formula:
Structure: c=cH2
Chemical Properties
Molecular Weight: 118.18
Vapor Pressure: 1 mm at 7.4°C
Boiling Point: 165.4°C at 760 mm
Density: 0.9106 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Physical State: Liquid
Vapor Density: 4.08
Melting Point: -23.21°C
Solubility: Insoluble (H2O)
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-moderate
Explosion—moderate
AIII-222
-------
a-Methylstyrene
PRODUCTION DATA
Annual U.S.
Production: 65 x 106 Ibs.
(1976 capacity)
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Consumption: 50 x 106 Ibs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
LCLo
Non-lethal Acute Effects:
Irritant
TCLo
Conjunctivitis
Dermatitis
4900 mg/kg
3000 ppm
3000 ppm
600 ppm
Animal
rat
rat
guinea pig
human
Route
oral
inhalation
inhalation
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA: 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-223
-------
Mevinphos
CHEMICAL NAME
CAS Number: 298-01-1
Chemical Name: 3-[(Dimethoxyphosphinyl)oxy ] -2-butenoic acid, methyl ester, (E)
Synonyms:
Molecular
Formula:
Mevinphos
2-Carbomethoxy-l-methyl-vinyldimethyl phosphate, a isomer
Phosdrin
C7H,306P
Structure:
CH3O
CH3O
O HO
II I II
P-O-C = C-C- OCH,
I J
CH
Chemical Properties
Molecular Weight: 224.17
Vapor Pressure: 0.0029 at 21°C
Boiling Point: 99 to 103°C at 0.03 mm
Density: 1.25
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility: Infinite (H2O)
Safety Hazard:
AIII-224
-------
Mevinphos
Annual U.S.
Production:
Fraction of
Dispersion:
x 106 Ibs.
PRODUCTION DATA
Consumption:
Estimated as 1.0
Release Rate (million Ibs/yr):
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LDSO
4mg/kg
4 mg/'kg
LC
50
211jjg/kg
4mg/kg
3mg/kg
4700 /ig/kg
7520 Mg/kg
3 mg/kg
14 ppm (1 hour)
Animal
rat
rat
rat
rat
mouse
mouse
rabbit
chicken
wild bird
rat
Route
oral
skin
intraperitoneal
subcutaneous
oral
intraperitoneal
skin
oral
oral
inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 400 Mg/
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-225
-------
Mirex
CHEMICAL NAME
CAS Number: 2385-85,5
Chemical Name: l,la,2,2,3,3a>4,5,5,5a,5b,6-Dodecachlorooctahydro-l,3,4-metheno-l H-cyclobuta(cd)
pentalene
Synonyms: Mirex
DodecacMoropentacyclo(3,3,2,02 '6,63 '9,07 (1 °) decane
Molecular
Formula:
Structure:
J?
Cl
\
Cl -*. „.
Cl Cl
Chemical Properties
Molecular Weight: 545.6
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Cl
Cl
Cl
. Cl
Cl
_
Cl
Physical State: Solid
Vapor Density:
Melting Point: 485°C (decomposes)
Solubility: Insoluble (H2O)
Safety Hazard:
AIII-226
-------
Annual U.S.
Production:
x 106 Ibs.
PRODUCTION DATA
Consumption:
Fraction of
Dispersion: Estimated as 1.0
Release Rate (million Ibs/yr): i
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LDSO
300-600 mg/kg
306 mg/kg
Animal
rat
rat
Chronic Toxicity
U.S. Occupational Standard:
Carcinogemcity:
TDLo
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
2222 mg/kg (58 weeks) mouse
TLV:
Route
oral
oral
oral
AIII-227
-------
Monosodium glutamate
CHEMICAL NAME
CAS Number: 14247-2
Chemical Name: L - Glutamic acid, monosodium salt
Synonyms: Monosodium glutamate
MSG
Sodium-L-glutamate
Molecular
Formula: CsH9NO4.Na
O HO
Structure: Na O - C - CH2 - CH2 - C - C -
Chemical Properties
Molecular Weight: 170.14 Physical State: Solid
Vapor Pressure: Negligible at 25°C Vapor Density:
Boiling Point: Decomposes Melting Point:
Density: Solubility: Soluble (7 39 gm/lH2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD: 65% of theoretical at 20°C for 5 days
Total theoretical oxygen demand = 1.42 gm/gm
Atmospheric Reactivity:
Safety Hazard:
AI11-228
-------
Monosodium glutamate
PRODUCTION DATA
Annual U.S.
Production: 47.3 x 106 Ibs.
Fraction of
Dispersion: 1.0
Release Rate (million Ibs/yr): S1.4
Consumption: 49.9 x 106
Fraction of Pro-
duction Lost: 0.03
TOXICITY DATA
Acute Toxicity
LDSO
Non-lethal Acute Effects:
Systematic effects:
Dosage
4253 mg/kg
8000 mg/kg
43 mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
TDLo
Other Chronic Effects:
5 mg/kg
Animal
rat
cat
human
TLV:
pregnant mouse
(17 or 18 days)
Route
intraperitoneal
subcutaneous
oral
parenteral
AIII-229
-------
Morpholine
CHEMICAL NAME
CAS Number: 110-91-8
Chemical Name: Morpholine
Synonyms: Tetrahydio-l,4-isoxazine
Diethethylenimide oxide
Molecular
Formula: C4H9NO
H
I
•
Structure:
Chemical Properties
Molecular Weight: 87.12 Physical State: Liquid
Vapor Pressure: 10 mm at 23°C Vapor Density: 3.00
Boiling Point: 128.3°C at 760 mm Melting Point: -4.75°C
Density: 1.0005 at 20°C/4°C Solubility: Infinite (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD: 0.9% of theoretical
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard: Fire-moderate
Disaster hazard—dangerous—toxic fumes—NOX
AIII-230
-------
Morpholine
PRODUCTION DATA
Annual U.S.
Production: 23.3 x 106 Ibs.
Fraction of
Dispersion: 0.50
Release Rate (million Ibs/yr): 12.4
Consumption: 23.3 x 10 Ibs.
Fraction of Pro-
duction Lost: 0.03
TOXICITY DATA
Acute Toxicity
LD50
Non-lethal Acute Effects:
Local irritant
Kidney damage
Dosage
1050 mg/kg
500 mg/kg
Animal
rat
rabbit
Chronic Toxicity
U.S. Occupational Standard: (aii) TWA 20 ppm (skin)
Carcinogenicity:
Neoplastic effects:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
6330 mg/kg (28 weeks) mouse
TLV: 20ppm
Route
oral
skin
oral
AIII-231
-------
MSMA
CHEMICAL NAME
CAS Number: 2163-80-6
Chemical Name: Methanearsonic acid, monosodium salt
Synonyms: MSMA
Monosodium acid methane arsonate
Molecular __ _
Formula: CH4AsO, • Na
Structure:
CH3 - As = O
OH
Chemical Properties
Molecular Weight: 162.97
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Na^
Physical State: Solid
Vapor Density:
Melting Point: 161°C
Solubility: Very soluble (H2O)
Safety Hazard:
AIII-232
-------
MSMA
Annual U.S.
Production: 35.0 x 106 Ibs.
Fraction of
Dispersion: Estimated as 1.0
Release Rate (million Ibs/yr): 35
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost: 0.015
Acute Toxicity
LDso
TOXICITY DATA
1800 mg/kg
50 mg/kg
Animal
rat
mammal
Route
oral
umeported
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AI11-233
-------
Nabam
CHEMICAL NAME
CAS Number: 142-59-6
Chemical Name: Ethylenebis(dithiocaibamic acid), disodium salt
Synonyms: Disodium ethylene bisdithiocaibamate
Molecular
Formula: C4H6N2S4-Na
Structure:
H S
CH2 - N - C - S (-) Na (
J_ I
H S
Chemical Properties
Molecular Weight: 256.4 Physical State: Solid
Vapor Pressure: Vapor Density:
Boiling Point: Melting Point: 79 to 81°C
Density: Solubility: Soluble (H2O)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Disaster hazaid-dangeious, toxic fumes
AI11-234
-------
Nabam
PRODUCTION DATA
Annual U.S.
Production: 1.4 x 106 Ibs. (1967) Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 395 mg/kg rat oral
580 mg/kg mouse oral
Non-lethal Acute Effects:
Irritant to skin and mucous membranes
Narcotic in high concentrations
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Potential carcinogen according to EPA
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AI11-235
-------
Naled
CHEMICAL NAME
CAS Number: 300-76-5
Chemical Name: Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester
Synonyms: l,2-Dibromo-2,2-dichloroethyl dimethylphosphate
Dimethyl-1,2-dibromo-2,2-dichloroethyl phosphate
Molecular
Formula:
O Br Br
CH30 ^|| ||
Structure: p_o-C-C-Cl
CH30 " , |
H Cl
Chemical Properties
Molecular Weight: 380.7 . , Physical State: Solid
Vapor Pressu re: Vap or Density:
Boiling Point: Melting Point: 270°C
Density: Solubility: Insoluble (H2O (hydrolyzes)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
AIII-236
-------
Naled
PRODUCTION DATA
Annual U.S.
Production: 2.0 x 106 Ibs. Consumption:
Fraction of Fraction of Pro-
Dispersion: 1-0 duction Lost: 0.015
Release Rate (million Ibs/yr): 2.0
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 250 mg/kg tat oral
800mg/kg rabbit skin
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 3 mg/m3
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-237
-------
Naphtha (solvent)
CHEMICAL NAME
CAS Number: MX 8030-31-7
Chemical Name: Coal tar naphtha
Synonyms: Solvent naphtha
Heavy naphtha
Hiflash naphtha
Molecular
Formula:
Structure: (Mixture of xylene and higher homologs)
Chemical Properties
Molecular Weight: Physical State: Liquid
Vapor Pressure: Vapor Density:
Boiling Point: 160 to 220°C Melting Point:
Density: 0.885 to 0.970 Solubility:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Reacts with oxidizing materials
Common air contaminant
Safety Hazard:
Fire-dangerous
Explosion-slight
AIII-238
-------
Naphtha (solvent)
PRODUCTION DATA
Annual U.S.
Production: 8288.4 x 106 Ibs. Consumption: 8288.4 x 106 Ibs.
Fraction of
Dispersion: l-°
Release Rate (million Ibs/yr): 8371.3
Fraction of Pro-
duction Lost: 0.01
Acute Toxicity
TOXICITY DATA
Dosage Animal
1600ppm rat
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity: Recognized carcinogen
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 100 ppm
Route
inhalation
AIII-239
-------
Naphthalene
CHEMICAL NAME
CAS Number: 91-20-3
Chemical Name: Naphthalene
Synonyms: Napthene
Molecular
Formula:
Structure:
Chemical Properties
Molecular Weight: 128.19 Physical State: Solid
Vapor Pressure: 0.2129 mm at 25°C Vapor Density: 4.42
Boiling Point: 218°C Melting Point: 80.55°C
Density: 1.0253 at 20°C/4°C Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient: 3.27
Environmental Persistence
BOO: Total theoretical oxygen demand: 3gm/gm
Atmospheric Reactivity:
Reacts with oxidizing materials
Activity toward OH: .tw = 2.5 days
03: tv4 = 1 year
ROj: unieactive
. Minor contaminant in air
Safety Hazard:
Fire -moderate
Explosion-moderate
AIII-240
-------
Naphthalene
PRODUCTION DATA
Annual U.S.
Production: 143 x 106 Ibs. (1975)
Fraction of
Dispersion: 0.02
Release Rate (million Ibs/yr): 16.9 (unspecified year)
Consumption: 140 x 106 Ibs. (1975)
Fraction of Pro-
duction Lost: 0.01
TOXICITY DATA
Acute Toxicity
LDSO
LE>Lo
Non-lethal Acute Effects:
Nausea
Anemia
Liver damage
Convulsions
Coma
1780 mg/kg
100 mg/kg
150 mg/kg
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 10 ppm
Animal
rat
child
mouse
Route
oral
oral
intraperitoneal
Carcinogenicity:
Neoplasm
TDLo
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
3500 mg/kg (98 days intermittent)
tLV: 10 ppm
AIII-241
-------
a-Naphthalenesulfonic acid
CHEMICAL NAME
CAS Number: 85-47-2
Chemical Name: 1-Naphthalenesulfonic acid
Synonyms:
Molecular
Formula: Ci0H8O3S
SO,H
Structure:
Chemical Properties
Molecular Weight: 208.25
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Disastet hazard-dangerous, toxic fumes of SOX
Physical State: Solid
Vapor Density:
Melting Point: 139tol40°C
Solubility: Soluble (H2O)
AIII-242
-------
a-Naphthalenesulfonic acid
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-243
-------
B-Naphthalenesulfonic acid
CHEMICAL NAME
CAS Number: 120-18-3
Chemical Name: 2-Naphthalenesulfonic acid
Synonyms: Naphthalene-2-sulfonic acid
Molecular
Formula:
Structure:
Chemical Properties
Molecular Weight: 208.25
Vapor Pressure:
Boiling Point: Decomposes
Density: 1.441 at 25°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Disaster hazard-dangerous, toxic fumes of SOX
Physical State: Solid
Vapor Density:
Melting Point: 124tol25°C
Solubility: Very soluble (H2O)
AIII-244
-------
B-Naphthalenesulfonic acid
PRODUCTION DATA
Annual U.S.
Production: 39.0 x 106 ibs. (1968) Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSo 400 mg/kg tat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-245
-------
a-Naphthol
CHEMICAL NAME
CAS Number: 90-15-3
Chemical Name: 1-Naphthol
Synonyms: 1-Hydioxynaphthalehe
Molecular
Formula: Ci0H8O
OH
Structure:
Chemical Properties
Molecular Weight: 144.19 Physical State: Solid
Vapor Pressure: l mm at 94°C Vapor Density:
Boiling Point: 288°C (sublimes) at 760 mm Melting Point: 96°C
Density: 1.0989 at 99°C/4°C Solubility: Insoluble (H2O)
Slightly soluble (hot HjO)
Octanol/Water Parti-
tion Coefficient: 2.98
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fiie-slight
AIII-246
-------
a-Naphthol
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 2590mg/kg rat oral
880 mg/kg rabbit skin
Non-lethal Acute Effects:
Nephritis
Circulatory collapse
Anemia
Convulsions
Injury to cornea and lens of eye
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AI11-247
-------
B-Naphthol
CHEMICAL NAME
CAS Number: 135-19-3
Chemical Name: 2-Naphthol
Synonyms:
Molecular
Formula:
2-Hydroxy naphthalene
Naphthol B
C10H80
Structure:
Chemical Properties
Molecular Weight: 144.19
Vapor Pressure: 15 mm at 128.6°C
Boiling Point: 295°C at 760 mm
Density: 1.28at20°C
Octanol/Water Parti-
tion Coefficient: 2.89
Environmental Persistence
BOO: 93% of theoretical after 12 days
Atmospheric Reactivity:
Safety Hazard:
Fire-slight
Physical State: Solid
Vapor Density: 4.97
Melting Point: 123 to 124°C
Solubility: Insoluble (H2O)
Slightly soluble (hot H2O)
AIII-248
-------
B-Naphthol
PRODUCTION DATA
(none in 1975 or 1976)
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Consumption:
Fraction of Pro-
duction Lost:
0.1 xlO°lbs. (1975)
TOXICITY DATA
Acute Toxicity Dosage
LDSO 2420 mg/kg
LDLo 2940 mg/kg
100 mg/kg
3800 mg/kg
2670 mg/kg
Non-lethal Effects:
Nephritis
Circulatory collapse
Anemia
Convulsions
Damage to cornea and lens of eye
Animal
rat
rat
mouse
rabbit
guinea pig
Route
oral
subcutaneous
subcutaneous
oral
subcutaneous
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-249
-------
1-Naphthylamine
CHEMICAL NAME
CAS Number: 134-32-7
Chemical Name: l-Naphthylamine
Synonyms: a-Naphthylamine
Molecular
Formula: C10H9N
Structure:
Chemical Properties
Molecular Weight: 143.20 Physical State: Solid
Vapor Pressure: 1 mm at 104.3°C Vapor Density: 4.93
Boiling Point: 300.8°C at 760 mm Melting Point: 50°C
Density: 1.1229 at 25°C/25°C Solubility: Slightly (H2O)
Octanol/Water Parti-
tion Coefficient: 2.22
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire-slight-toxic fumes
AIII-250
-------
1-Naphthylamine
PRODUCTION DATA
Annual U.S.
Production:
Fraction of
Dispersion:
I.lxl06lbs. (1963)
Consumption:
Fraction of Pro-
duction Lost:
0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity
LD50
Dosage
779 mg/kg
300 mg/kg
4000 mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Urinary bladder cancer
TDLo 400 mg/kg
Neoplastic effects:
TDLo 25 mg/kg
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Animal
rat
rabbit
mammal
Route
oral
subcutaneous
oral
dog
TLV:
subcutaneous
subcutaneous
AIII-251
-------
2-Naphthylamine
CHEMICAL NAME
CAS Number: 91-59-8
Chemical Name: 2-Naphthylamine
Synonyms: 0-Naphthylamine
Molecular
Formula:
Structure:
NH-
Chemical Properties
Molecular Weight: 143.20
Vapor Pressure: 1 mm at 108°C
Boiling Point: 306.1°C
Density: 1.0614 at 98°C/4°C
Octanol/Water Parti-
tion Coefficient: 2.25
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-moderate-toxic fumes
Physical State: Solid
Vapor Density:
Melting Point: 113°C
Solubility: Soluble (H2O)
(Very soluble in hot H2O)
AIII-252
-------
2-Naphthylamine
PRODUCTION DATA
1.28xl06lbs. (1955)
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Consumption:
Fraction of Pro-
duction Lost:
0.015
TOXICITY DATA
Acute Toxicity
LDSO
Dosage
727 mg/kg
200 mg/kg
500 mg/kg
Animal
rat
mouse
dog
Route
oral
intraperitoneal
unknown
Chronic Toxicity
U.S. Occupational Standard: Carcinogen
Carcinogenicity:
TDLo
Neoplastic effects:
TDLo
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
118 mg/kg (78 weeks)
2120 mg/kg (52 weeks)
18 mg/kg
3900 mg/kg (2 years)
14 mg/kg (240 weeks)
365 gm/kg (43 weeks)
31 gm/kg (1 year)
42 mg/kg
260 mg/kg (43 weeks)
rat
mouse
mouse
dog
monkey
hamster
rat
mouse
hamster
TLV:
subcutaneous
subcutaneous
parenteral
oral
oral
oral
oral
subcutaneous
oral
AIII-253
-------
Naptalam
CHEMICAL NAME
CAS Number: 132-67-2
Chemical Name: 2-[(l-Naphthalenylamino)carbonyl]benzole acid, monosodium salt
Synonyms: N-Naphthyl phthalatnic acid, sodium salt
Molecular
Formula: C18H13NO3-Na
Structure:
Chemical Properties
Molecular Weight: 291.3
Vapor Pressure:
Boiling Point:
Density: 1.40 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 185°C
Solubility: 0.2 gm/100 ml H2O
Safety Hazard:
Fire-moderate
AIII-254
-------
Naptalam
Annual U.S.
Production:
Fraction of
Dispersion:
2.0 x 106 Ibs.
Estimated as 1
Release Rate (million Ibs/yr): 2
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
0.015
TOXICITY DATA
Acute Toxicity
LD50
Dosage
1770 mg/kg
> 5 mg/kg
Animal
rat
dog
Non-lethal Acute Effects:
Relatively non-toxic to warm-blooded animals
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
Route
oral
oral
AIII-255
-------
Neopentanoic acid
CHEMICAL NAME
CAS Number: 75-98-9
Chemical Name: Pivalic acid
Synonyms: Neopentanoic acid
2,2-Dimethyl propanoic acid
Trimethyl acetic acid
Molecular
Formula: C5H10O2
CH,
---
Structure: CH3 - C - C
i__ X OH
CH3
Chemical Properties
Molecular Weight: 102.13 Physical State: Solid
Vapor Pressure: Vapor Density:
Boiling Point: 163.7 to 163.8°Cat760 mm Melting Point: 35.3 to 35.5°C
Density: 0.905 at 50°C Solubility: Slightly (H2O)
Octanol/Water Parti-
tion Coefficient: 1.60
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AIII-256
-------
Neopentanoic acid
PRODUCTION DATA
Annual U.S.
Production: 5 x 10 Ibs. (1975 capacity Consumption:
for neo-acids)
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr);
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDLo 5000mg/kg rat oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-257
-------
Nitrilotriacetic acid, trisodium salt
CHEMICAL NAME
CAS Number: 5064-31-3
Chemical Name: N,N-bis(carboxymethyl)glycine, trisodium salt
Synonyms:
Molecular
Formula:
NTA, trisodium salt
Triglycine, trisodium salt
TGA, trisodium salt
Triglycolamic acid, trisodium salt
O
O
Structure: Na(+)(~)0 - C - H2C - N - CH2 - C - O( } Na(+)
CH2-C- i
O
Na
(+)
Chemical Properties
Molecular Weight: 260.13
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD: 76% of theoretical after 20 days at 20° C
Total theoretical oxygen demand = 0.93 gm/gm
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point:
Solubility:
Acid form -240° C with
decomposition
Soluble (H2O)
Safety Hazard:
Fire —combustible
AIII-258
-------
Nitrilotriacetic acid, trisodium salt
PRODUCTION DATA
Annual U.S.
Production: 85 x 106 Ibs.
Fraction of
Dispersion: 1.0
Release Rate (million Ibs/yr): 14.3
Consumption: 13xl06lbs.
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LD50
1100 mg/kg
254 mg/kg
681 mg/kg
750 mg/kg
Animal
rat
rat
mouse
monkey
Route
oral
intra peritoneal
oral
oral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
(Nitrilotriacetic acid is a confirmed carcinogen, causing
urinary tract cancers in rats and mice.)
Mutagenicity:
Teratogenicity: Birth abnormalities may result TLV:
from ingest ion
Other Chronic Effects:
AIII-259
-------
p-Nitroaniline
CHEMICAL NAME
CAS Number: 100-01-6
Chemical Name: p-Nitroaniline
Synonyms: l-Amino-4-nitrobenzene
Fast red 2G base
Molecular
Formula:
Structure:
,- NH2
Chemical Properties
Molecular Weight: 138.13
Vapor Pressure: 1 mm at 142.4°C
Boiling Point: 331.73°C
Density: 1.424 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 1-41
Environmental Persistence
800:
Atmospheric Reactivity:
Safety Hazard:
Fire-slight
Physical State: Solid
Vapor Density:
Melting Point: 148.5 to 149.5°C
Solubility: Insoluble (H2O)
(Slightly in hot H2O)
AIII-260
-------
p-Nitroaniline
PRODUCTION DATA
Annual U.S.
Production: 8.17 x 106 Ibs. (1967)
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Consumption:
Fraction of Pro-
duction Lost:
0.015
TOXICITY DATA
Acute Toxicity
LDLo
Non-lethal Acute Effects:
Cyanosis
Nausea and vomiting
Convulsions
Dosage
3249 mg/kg
812mg/kg
250 mg/kg
75 mg/kg
40 mg/kg
Chronic Toxicity
U.S. Occupational Standard: (air) 1 ppm (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Liver damage
Animal
rat
mouse
mouse
wild bird
mammal
Route
oral
oral
intraperitoneal
oral
intravenous
TLV: 1 ppm (skin)
AIII-261
-------
Nitroanisole
CHEMICAL NAME
CAS Number: 100-17-4
Chemical Name: 1-Methoxy^-nitrobenzene
Synonyms:
Molecular
Formula: C7H7NO3
Structure:
Chemical Properties
Molecular Weight: 153.14 Physical State: Solid
Vapor Pressure: Vapor Density:
Boiling Point: 276.8°C at 757 mm Melting Point: 54°C
Density: 1.2192at60°C/4°C Solubility: Insoluble (H2O)
Octanol/Water Parti-
tion Coefficient: 2.03
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
AIII-262
-------
Nitroanisole
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 4700 mg/kg mammal (unspecified) oral
1400 mg/kg mammal (unspecified) intraperitoneal
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-263
-------
Nitrobenzene
CHEMICAL NAME
CAS Number:
Chemical Name:
98-95-3
Nitrobenzene
Synonyms: Oil of mirbane
Nitrobenzol
Mononitrobenzene
Molecular
Formula: C6HSNO2
N02
Chemical Properties
Molecular Weight: 123.06
Vapor Pressure: 0.284 mm at 25°C
Boiling Point: 210.8°C at 760 mm
Density: 1.2037 at 20° C/4°C
Octanol/Water Parti-
tion Coefficient: 1.88
Artificial oil of bitter almonds
Solvent black 5
Nigrosine spirit soluble B
Physical State: Solid/oily liquid
Vapor Density: 4.25
Melting Point: 5.7°C
Solubility: Slightly (1 gm/100 ml H2O at 20°C)
Environmental Persistence
BOD: Total theoretical oxygen demand = 1 .95 gm/gm
Atmospheric Reactivity:
Biodegradable
Unreactive to 03 (tyi =11 years) and ROj
OH: tw = 3 days
Safety Hazard:
Fire -moderate
Explosion - moderate
Disaster hazard-moderate—toxic fumes-NO,
2000 years)
AIII-264
-------
Nitrobenzene
PRODUCTION DATA
Annual U.S.
Production: 551.2 x 106 Ibs. (1974) Consumption: 551.2 x 106 Ibs.
Fraction of
Dispersion: 0.03
Release Rate (million Ibs/yr): 19-3
Fraction of Pro-
duction Lost: 0.012
Acute Toxicity
TOXICITY DATA
Dosage Animal Route
800 mg/kg rat subcutaneous
400 mg/kg mouse skin
480 mg/kg mouse subcutaneous
750 mg/kg dog oral
150 mg/kg dog intravenous
2000 mg/kg cat oral
700 mg/kg rabbit oral
600 mg/kg rabbit skin
1000 mg/kg mammal oral
(unspecified)
ca. 80 mg/kg human oral
Non-lethal Acute Effects:
Blood effects
TDj_,0 200 mg/kg human female oral
Cyanosis due to formation of methemoglobin
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 1 ppm (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity: 125 mg/kg subcutaneous TLV: 5 mg/m3 (1 ppm)
In rat, caused delayed embryogenesis, embryo malformation and death
Other Chronic Effects:
Heart, liver and kidney damage
CNS effects
All1-265
-------
p-Nitrobenzoic acid
CHEMICAL NAME
CAS Number: 62-23-7
Chemical Name: p-Nitrobenzoic acid
Synonyms: 4-Nitrobenzoic acid
Molecular
Formula: C7H5NO4
Structure:
C - OH
II
o
Chemical Properties
Molecular Weight: 167.12
Vapor Pressure: <10 mm at 25°C
Boiling Point: Sublimes
Density: 1.610 at 20°C
Octanol/Water Parti-
tion Coefficient: 2.03
Environmental Persistence
BOO:
Atmospheric Reactivity:
Physical Stafe: Solid
Vapor Density:
Melting Point: 242°C
Solubility: Insoluble (H2O)
Safety Hazard:
Diaster hazard—dangerous toxic fumes-NOx
AIII-266
-------
p-Nitrobenzoic acid
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 1960 mg/kg rat oral
1210mg/kg rat intraperitoneal
1960 mg/kg rat parenteral
880 mg/kg mouse intraperitoneal
770 mg/kg mouse intravenous
1470 mg/kg mouse parenteral
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-267
-------
Nitrocellulose
CHEMICAL NAME
CAS Number: 9004-70-0
Chemical Name: Nitrate cellulose
Synonyms:
Nitrocellulose
Cellulose nitrate
Celloidin
Pyroxylin
Collodion
Molecular
Formula: (C6H7N3bu)n
Structure:
.O
I- O2NO
Chemical Properties
Molecular Weight: (297.13)n
Vapor Pressure: Negligible at 25°C
Boiling Point:
Density: 1-66
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-highly dangerous
Explosion-moderately dangerous
n=>2
Physical State: Solid
Vapor Density:
Melting Point:
Solubility: Insoluble (H2O)
AIII-268
-------
Nitrocellulose
PRODUCTION DATA
Annual U.S.
Production: 50xl06lbs. Consumption: 50xl06lbs.
Fraction of Fraction of Pro-
Dispersion: !-° duction Lost: 0.03
Release Rate (million Ibs/yr): 51.5
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Low toxicity
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-269
-------
Nitrpethane
CHEMICAL NAME
CAS Number: 79-24-3
Chemical Name: Nitroethane
Synonyms:
Molecular
Formula: C2HSNO2
Structure: CH3 - CH2 - NO2
Chemical Properties
Molecular Weight: 75.08
Vapor Pressure: 20.3 mm at 25°C
Boiling Point: 115°C at 760mm
Density: 1.0448 at 25°C/4°C
Octanol/Water Parti-
tion Coefficient: 0.18
Environmental Persistence
BOO:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density: 2.58
Melting Point: -50°C
Solubility: Slightly (H2O)
Safety Hazard:
Fire-moderate
Explosion-dangerous
Disaster hazard—dangerous—toxic fumes NOX
AIII-270
-------
Nitroethane
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 1100mg/kg rat oral
860 mg/kg mouse oral
LDLo 500 mg/kg rabbit oral
Non-lethal Acute Effects:
Local irritant to eyes and respiratory tract
Dermatitis
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 100 ppm
Other Chronic Effects:
AIII-271
-------
Nitroglycerine
CHEMICAL NAME
CAS Number:
Chemical Name:
Synonyms:
55-63-0
Nitroglycerine
Ethylene glycol trinitrate
Glycerol trinitrate
Trinitrin
Molecular
Formula: C3HSN3O9
H2 - C - O - N02
Structure: H - C - O - NO2
H2C - O - NO2
Chemical Properties
Molecular Weight: 227.09
Vapor Pressure: 1 mm at 127°C
Boiling Point: 256°C (explodes)
Density: 1.5931 at 20° C/4°C
Octanol/Water Parti-
tion Coefficient: 0.35
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-dangerous
Explosion-severe
Disaster hazard-very dangerous-toxic fumes
GMT
NT
Physical State: Liquid
Vapor Density: 7.84
Melting Point: 13°C
Solubility: Slightly (H2O)
AIII-272
-------
Nitroglycerine
PRODUCTION DATA
Annual U.S.
Production: "^ Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDLo 80 rng/kg rat oral
40 mg/kg rabbit intravenous
275 mg/kg rat intramuscular
150 mg/kg cat subcutaneous
400 mg/kg rabbit subcutaneous
450 mg/kg rabbit intramuscular
Non-lethal Acute Effects:
Respiratory paralysis
Skin irritation
Vomiting
Chronic Toxicity
U.S. Occupational Standard: (air) 2 mg/m3 (skin)
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 2 mg/m3
Other Chronic Effects:
AIII-273
-------
Nitromethane
CHEMICAL NAME
CAS Number: 75-52-5
Chemical Name: Nitromethane
Synonyms: Nitrocarbol
Molecular
Formula: CH3NO2
Structure: H -
H
I
C - NO2
I
H
Chemical Properties
Molecular Weight: 61.04
Vapor Pressure: 36.27 mm at 25°C
Boiling Point: 100.8°C at 760 mm
Density: 1.1371 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 0.17
Environmental Persistence
BOD:
Atmospheric Reactivity: Reacts with oxidizing materials
Safety Hazard:
Fire—dangerous
Explosion - moderate
Disaster hazard—dangerous-toxic fumes of NOX
Physical State: Liquid
Vapor Density: 2.11
Melting Point: -17°C
Solubility: Soluble (H2O)
AIII-274
-------
Nitromethane
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 940 mg/kg rat oral
950 mg/kg mouse oral
LDLo 125 mg/kg dog oral
565 mg/kg dog subcutaneous
800 mg/kg dog intravenous
750 mg/kg rabbit oral
750 mg/kg rabbit intravenous
LCLo 2446 mg/m3 monkey inhalation
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 100 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV: 100 ppm
Other Chronic Effects:
Nausea
Vomiting
Kidney and liver damage
Irritates eyes
AIII-275
-------
m-Nitrophenol
CHEMICAL NAME
CAS Number: 554-84-7
Chemical Name: 3-Nitrophenol
Synonyms:
Molecular
Formula: C6HSNO2
OH
Structure:
NO,
Chemical Properties
Molecular Weight: 139.11
Vapor Pressure: 10 mm at 25°C
Boiling Point: 194°C at 70 mm
Density: 1.2797 at 100°C/4°C
Octanol/Water Parti-
tion Coefficient: 2.05
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Disaster hazard-dangerous-toxic fumes-NOx
Physical State: Solid
Vapor Density:
Melting Point: 97°C
Solubility: Slightly (H2O)
(Very soluble in hot H2O)
AIII-276
-------
m-Nitrophenol
PRODUCTION DATA
Annual U.S.
Production: 14.8 x 106 Ibs. Consumption:
(1967 all nitiophenols)
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LDSO 447 mg/kg rat oral
1414 mg/kg mouse oral
83 mg/kg dog intravenous
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
All1-277
-------
o-Nitrophenol
CHEMICAL NAME
CAS Number: 88-75-5
Chemical Name: o-Nitrophenol
Synonyms: 2-Hydroxynitrobenzene
Molecular
Formula: C6HSNO3
OH
Structure:
NCX,
Chemical Properties
Molecular Weight: 139.11
Vapor Pressure: 1 mm at 49.3°
Boiling Point: 216°Cat760mm
Density: 1.485 at 14°c
Octanol/Water Parti-
tion Coefficient: 3-58
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Solid
Vapor Density:
Melting Point: 45.3 to 45.7°C
Solubility: Slightly (H2O)
Safety Hazard:
Diaster hazard-dangerous-toxic fumes NOX
AIII-278
-------
o-Nitrophenol
PRODUCTION DATA
Annual U.S.
Production: 14.8 x 106 Ibs. Consumption:
(1967 all nitrophenols)
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.015
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 2828mg/kg rat oral
1297 mg/kg rat oral
LDL0 100 mg/kg dog intravenous
Non-lethal Acute Effects:
Liver and kidney damage
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-279
-------
p-Nitrophenol
CHEMICAL NAME
CAS Number: 100-02-7
Chemical Name: p-Nitrophenol
4-Nitrophenol
Synonyms:
Molecular
Formula: C6HSNO3
Structure:
Chemical Properties
Molecular Weight: 139.11
Vapor Pressure:
Boiling Point: 279°C (decomposes)
Density: 1.479 at 20°C
Octanol/Water Parti-
tion Coefficient: 1.97
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Disaster hazaid-dangerous-toxic fumes-NOx
Physical State: Solid
Vapor Density:
Melting Point: 114.9 to 115.6°C
Solubility: Slightly (H2O)
AIII-280
-------
p-Nitrophenol
PRODUCTION DATA
Annual U.S.
Production: 52 x 106 Ibs. (1976 capacity)
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
Consumption:
Fraction of Pro-
duction Lost: 0.015
TOXICITY DATA
Acute Toxicity
LDSO
LDLo
Non-lethal Acute Effects:
Hyperthermia
Methemoglobinemia
CNS depression
Dosage
350 mg/kg
467 mg/kg
75 mg/kg
150 mg/kg
65 mg/kg
10 mg/kg
500 mg/kg
Animal
rat
mouse
mouse
cat
pigeon
dog
dog
Route
oral
oral
intraperitoneal
intiaperitoneal
intramuscular
intravenous
intraperitoneal
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-281
-------
l-Nitropropane
CHEMICAL NAME
CAS Number: 108-03-2
Chemical Name: 1-Nitropropane
Synonyms:
Molecular
Formula: C3H7NO2
Structure: CH3 - CH2.- CH2 - NO2
Chemical Properties
Molecular Weight: 81.11 Physical State: Liquid
Vapor Pressure: 9.87 mm at 25°C Vapor Density: 3.06
Boiling Point: 130.5 to 131.5°C at 760mm Melting Point: -108°C
Density: 1.0081 at 24°C/4°C Solubility: Slightly (H2O)
Octanol/Water Parti-
tion Coefficient: 2-4l
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-moderate
Explosion-dangerous
Disaster hazard—dangerous-toxic fumes NOX
AIII-282
-------
l-Nitropropane
Annual U.S.
Production:
Fraction of .
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
LDLo
Non-lethal Acute Effects:
Irritation of eyes
Vomiting
Dosage
800 mg/kg
250 mg/kg
1000 mg/kg
Animal
mouse
rabbit
rat
Route
oral
oral
oral
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 25 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV: 25 ppm
AIII-283
-------
2-Nitropropane
CHEMICAL NAME
CAS Number: 79-46-9
Chemical Name: 2-Nitropropane
Synonyms: Isonitropropane
Molecular
Formula: C3H7NO2
NO,
Structure: CH3 - C - CH3
H
Chemical Properties
Molecular Weight: 89.09
Vapor Pressure: 17.42 mm at 25°C
Boiling Point: 120°C at 760mm
Density: 0.9876 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density: 3.06
Melting Point: -93°C
Solubility: Slightly (H2O)
Safety Hazard:
Fire—moderate
Explosion-dangerous
Disaster hazard—dangerous—toxic fumes—NOX
AIII-284
-------
2-Nitropropane
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
LCLo
500 mg/kg
75 mg/kg
500 mg/kg
1513 ppm (5 hours)
714 ppm (5 hours)
2381 ppm (5 hours)
4622 ppm (5 hours)
Non-lethal Acute Effects:
Central nervous system effects
TDLo 15 ppm
Local irritant
Vomiting
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 25 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TOXICITY DATA
Animal
rat
mouse
rabbit
rat
cat
rabbit
guinea pig
human
Route
oral
intraperitoneal
oral
inhalation
inhalation
inhalation
inhalation
inhalation
TLV: 25 ppm
AIII-285
-------
N-Nitrosodiethylamine
CHEMICAL NAME
CAS Number: 55-18-5
Chemical Name: N-Nitrosodiethylamine
Synonyms:
Molecular
Formula: C4Hi0N2O
Structure:
CH3 - CH2
CH3 - CH2
N-N = O
Chemical Properties
Molecular Weight: 102.14
Vapor Pressure:
Boiling Point: 176.9°Cat 760mm
Density: 0.9422 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility: Soluble (H2O)
All1-286
-------
N-Nitrosodiethylamine
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
Lbso
TOXICITY DATA
Dosage Animal
216 mg/kg rat
11 mg/kg rat
157 mg/kg rat
246 mg/kg hamster
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
TD
'LO
Mutagenicity:
Teratogenicity:
TDLo
Other Chronic Effects:
45 mg/kg (83 weeks) rat
100 mg/kg rat
200 mg/kg (10-21 days rat
pregnant)
40 mg/kg rat
57 mg/kg mouse
560 mg/kg dog
18 gm/kg monkey
2 gm/kg monkey
960 mg/kg (28 weeks) rabbit
750 mg/kg (2.2 years) pig
TLV:
150 mg/kg (22 days rat
pregnant)
19 gm/kg (15-20 days mouse
pregnant)
17 mg/kg (pregnant) hamster
Route
oral
intraperitoneal
intravenous
unknown
oral
intraperitoneal
subcutaneous
intravenous
oral
oral
oral
intraperitoneal
oral
oral
intravenous
unknown
subcutaneous
AIII-287
-------
N-Nitrosodimethylamine
CHEMICAL NAME
CAS Number: 62-75-9
Chemical Name: N-Nitrosodimethylamine
Synonyms: Dimethylnitrosamine
Nitrous dimethyl amide
Molecular C2H6N2O
Formula:
Structure:
CH-.
CH,
N-N = O
Chemical Properties
Molecular Weight: 74.08
Vapor Pressure:
Boiling Point: 154°C at 760 mm
Density: 1.0059 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Disaster hazard—dangerous-toxic fumes
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility: Soluble (H2O)
AIII-288
-------
N-Nitrosodimethylamine
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LD50
LC50
Dosage
26 mg/kg
36 mg/kg
45 mg/kg
40 mg/kg
78 ppm (4 hours)
57 ppm (4 hours)
Non-lethal Acute Effects:
Irritant
Gastrointestinal hemorrhage
Liver damage
Chronic Toxicity
U.S. Occupational Standard:
(air) Carcinogen
Carcinogenicity:
TDLo
Neoplastic effects:
TDLo
Mutagenicity:
Teratogenicity:
TDLo
Other Chronic Effects:
248 mg/kg (31 weeks)
37 mg/kg
30 mg/kg (35 weeks)
370 mg/kg (56 weeks)
4375 Mg/kg
202 mg/kg (23 weeks)
30 mg/kg
18 mg/kg
18 mg/kg
18 mg/kg
7 mg/kg
13 mg/kg
Animal
rat
rat
rat
rat
rat
mouse
rat
rat
rat
mouse
mouse
rabbit
rat
rat
rat
rat
mouse
TLV:
mouse
Route
oral
intraperitoneal
subcutaneous
rectal
inhalation
inhalation
oral
inhalation
rectal
oral
subcutaneous
oral
intraperitoneal
intramuscular
parenteral
intravenous
intraperitoneal
unknown
AIII-289
-------
Nitrosoethylurea
CHEMICAL NAME
CAS Number: 759-73-9
Chemical Name: N-Ethyl-N-nitrosourea
Synonyms: l-Ethyl,l-nitrosourea
Molecular
Formula: C3H7N3O2
Structure:
H O CH2CH3
\ n /
N - C - N
\
H
N = O
Chemical Properties
Molecular Weight: 117.13
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-moderate
Physical State: Solid
Vapor Density:
Melting Point:
Solubility:
AIII-290
-------
Nitrosoethylurea
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
Non-lethal Acute Effects:
Dermatitis
Dosage
300 mg/kg
240 mg/kg
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
TDLo
Neoplasm
TDLo
Mutagenicity:
Teratogenicity:
10 mg/kg
5 mg/kg
20 mg/kg
2200 mg/kg (9 weeks)
60 mg/kg
Other Chronic Effects:
Animal
rat
rat
5 mg/kg (15 days
pregnant)
29 mg/kg (12-19 days
pregnant)
80 mg/kg (15 days
pregnant)
240 mg/kg (22-23 days
pregnant)
rat
rat
rat
mouse
mouse
TLV:
rat
rat
pig
Route
oral
intravenous
oral
subcutaneous
intravenous
subcutaneous
intraperitoneal
intravenous
intraperitoneal
parenteral
intravenous
All1-291
-------
Nitrosomethylurea
CHEMICAL NAME
CAS Number: 684-93-5
Chemical Name: N-Methyl-N-nitrosourea
Synonyms: l-Methyl,l-nitrosourea
Molecular
Formula:
H CH-
I I
Structure: H - N~- C - N - N = 6
II
6
Chemical Properties
Molecular Weight: 103.08
Vapor Pressure:
Boiling Point:
Density:
Octanol/Water Parti-
tion Coefficient: -0.16
Environmental Persistence
BOO:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Solid
Vapor Density:
Melting Point: 123tol24°C (decomposes)
Solubility: Insoluble (H2O)
All1-292
-------
Nitrosomethylurea
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
Acute Toxicity
LDSO
TOXICITY DATA
Animal
180 mg/kg rat
110 mg/kg rat
144 mg/kg • mouse
115 mg/kg hamster
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
TDLO
Mutagenicity:
Teratogenicity:
TDLO
Other Chronic Effects:
230 mg/kg (24 weeks)
180 mg/kg (36 weeks)
90 mg/kg
202 mg/kg (30 weeks)
70 mg/kg
50 mg/kg
10 mg/kg (13 days)
12 mg/kg (15-23 days)
rat
rat
rat
rat
rat
mouse
TLV:
rat
pregnant rat
Route
oral
intraperitoneal
intraperitoneal
subcutaneous
intiaperitoneal
subcutaneous
oral
skin
intravenous
intraperitoneal
intraperitoneal
intravenous
AIII-293
-------
m-Nitrotoluene
CHEMICAL NAME
CAS Number: 99-08-1
Chemical Name: m-Nitrotoluene
Synonyms: 3-Methylnitrobenzene
Molecular
Formula: C7H7NO2
CH,
Structure:
NO,
Chemical Properties
Molecular Weight: 137.14
Vapor Pressure: 1 mm at 50°C
Boiling Point: 232.6°Cat 760mm
Density: 1.1571 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient: 2.45
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-moderate
Physical State: Liquid
Vapor Density: 4.72
Melting Point: 16°C
Solubility: Insoluble (H2O)
AIII-294
-------
m-Nitrotoluene
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
Dosage
1072 mg/kg
330 mg/kg
2400 mg/kg
3600 mg/kg
Animal
rat
mouse
rabbit
guinea pig
Route
oral
oral
oral
oral
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 5 ppm
Carcinogen icity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
AIII-295
-------
o-Nitrotoluene
CHEMICAL NAME
CAS Number: 88-72-7
Chemical Name: o-Nitrotoluene
Synonyms: 2-Methylnitrobenzene
2-Nitrotoluene
Molecular
Formula: C7H7NO2
Structure:
Chemical Properties
Molecular Weight: 137.14
Vapor Pressure: 1 mm at 50°C
Boiling Point: 220.4°C at 760 mm
Density: 1-1629 at 20°C
Octanol/Water Parti-
tion Coefficient: 2.30
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Fire-moderate
Physical State: Liquid
Vapor Density: 4.72
Melting Point: -9.55°C
Solubility: Insoluble (H2O)
AIII-296
-------
o-Nitrotoluene
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
Dosage
891 mg/kg
2462mg/kg
Animal
rat
Chronic Toxicity
U.S. Occupational Standard: (aii) TWA 5 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
TLV:
Route
oral
oial
AIII-297
-------
p-Nitrotoluene
CHEMICAL NAME
CAS Number: 99-99-0
Chemical Name: p-Nitrotoluene
Synonyms:* 4-Methylnitiobenzene
Molecular
Formula: C7H7NO2
Structure:
NO-,
Chemical Properties
Molecular Weight: 137.14
Vapor Pressure: 1 mm at 53.7°C
Boiling Point: 238.3°C at 760mm
Density: 1.1038 at 75°C/4°C
Octanol/Water Parti-
tion Coefficient: 2.42
Environmental Persistence
BOD:
Atmospheric Reactivity:
Safety Hazard:
Physical State: Solid
Vapor Density: 4.72
Melting Point: 54.5°C
Solubility: Insoluble (H2O)
AIII-298
-------
p-Nitrotoluene
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr):
PRODUCTION DATA
Consumption:
Fraction of Pro-
duction Lost:
TOXICITY DATA
Acute Toxicity
LDSO
Dosage
2144 mg/kg
1231 mg/kg
940 mg/kg
Animal
rat
mouse
mammal
(unspecified)
Route
oial
oral
intrapeiitoneal
Chronic Toxicity
U.S. Occupational Standard: (air) TWA 5 ppm
Carcinogenicity:
Mutagsnicity:
Teratogenicity:
Other Chronic Effects:
TLV: 5 ppm (skin)
AIII-299
-------
Nonene
CHEMICAL NAME
CAS Number: 27215-95-8
Chemical Name: Nonene
Synonyms: Nonene (mixed isomers)
Nonylene
Molecular
Formula: C9H18
Structure: CH3 - (CH2)6 - CH = CH2
(1 - Nonene)
Chemical Properties
Molecular Weight: 126.19
Vapor Pressure:
Boiling Point: 149.9°C (1-nonene)
Density: 0.7433 (1-nonene)
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:
Atmospheric Reactivity:
Physical State: Liquid
Vapor Density:
Melting Point:
Solubility: Insoluble (H2O)
Safety Hazard:
Fire—combustible
AIII-300
-------
Nonene
PRODUCTION DATA
Annual U.S.
Production: Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost:
Release Rate (million Ibs/yr):
TOXICITY DATA
Acute Toxicity Dosage Animal Route
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-301
-------
Nonyl phenol
CAS Number: 25154-52-3
Chemical Name: Nonylphenol
Synonyms: p-Nonylphenol
Hydroxyl No. 253
Molecular
Formula: C15H24O
CHEMICAL NAME
Structure:
HO
C9H19
Chemical Properties
Molecular Weight: 220.34
Vapor Pressure: 10 mm at 25°C
Boiling Point: 290 to 302°C
Density: 0.949 at 20°C/4°C
Octanol/Water Parti-
tion Coefficient:
Environmental Persistence
BOD:,
Atmospheric Reactivity:
Rapidly biodegraded
Not reactive to 63 or ROj
Reacts with oxidizing materials
tw OH = 2 days
Safety Hazard:
Fire-slight
Physical State: Liquid
Vapor Density: 7.59
Melting Point:
Solubility: Insoluble (H2O)
AIII-302
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Nonyl phenol
PRODUCTION DATA
Annual U.S.
Production: 191 x 106 Ibs. (1976 capacity) Consumption:
Fraction of Fraction of Pro-
Dispersion: duction Lost: 0.007
Release Rate (million Ibs/yr): 180.6 (ethoxylated compound)
TOXICITY DATA
Acute Toxicity Dosage Animal Route
LD50 1620mg/kg rat oral
2140 mg/kg rabbit skin
Chronic Toxicity
U.S. Occupational Standard:
Carcinogenicity:
Mutagenicity:
Teratogenicity: TLV:
Other Chronic Effects:
AIII-303
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TECHNICAL REPORT DATA
(Please read Inunctions on the reverse before completing)
1. REPORT NO.
EPA-450/3-77-008d
2.
3. RECIPIENT'S ACCESSION NO.
4.TiTLVMjTfMfffa(^ scoring of Organic Air Pollutants:
Chemistry, Production and Toxicity of
Synthetic Organic Chemicals
(Chemicals F-N) Appendix III
5. REPORT DATE
October 1976
6. PERFORMING ORGANIZATION CODE
7. AUTHOR(S)
8. PERFORMING ORGANIZATION REPORT NO.
J. Dorigan, B. Fuller, R. Duffy
9. PERFORMING ORGANIZATION NAME AND ADDRESS
The Mitre Corporation
Metrek Division
Westgate Research Park
McLean, Virginia 22101
10. PROGRAM ELEMENT NO.
11. CONTRACT/GRANT NO.
68-02-1495
12. SPONS
NSORING AGENCY NAME AND ADDRES
EPA, Office of Air Quality Planning
Office of r
Strategies and Air Standards
Research Triangle Park, N.C.
and
Division
27711
Standards
13. TYPE OF REPORT AND PERIOD COVERED
14. SPONSORING AGENCY CODE
15. SUPPLEMENTARY NOTES
16. ABSTRACT
This is the third of a series of four appendices to the report "Scoring
of Organic Air Pollutants." The entire appendix contains a compilation of
available data on chemical structure and properties, environmental persistence,
production, and toxicity for 637 synthetic organic chemicals.
17.
KEY WORDS AND DOCUMENT ANALYSIS
DESCRIPTORS
b.lDENTIFIERS/OPEN ENDED TERMS C. COS ATI Field/Group
organic chemical
organic chemical
organic chemical
organic chemical
structure
properties
production
toxicity
18. DISTRIBUTION STATEMENT
unlimited
19. SECURITY CLASS (This Report)
unclassified
21. NO. OF PAGES
310
20. SECURITY CLASS (This page)
unclassified
22. PRICE
EPA Form 2220-1 (9-73)
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