EPA-450/3-77-008d
October 1976
      PRELIMINARY SCORING
      OF SELECTED ORGANIC
            AIR POLLUTANTS
               APPENDIX III -
  CHEMISTRY, PRODUCTION,
               AND TOXICITY
               OF CHEMICALS
                F THROUGH N
  U.S. ENVIRONMENTAL PROTECTION AGENCY
      Office of Air and Waste Management
   Office of Air Quality Planning and Standards
   Research Triangle Park, North Carolina 27711

-------
                                    EPA-450/3-77-008d
           PRELIMINARY SCORING


OF SELECTED ORGANIC AIR POLLUTANTS


                 APPENDIX III -


         CHEMISTRY, PRODUCTION,


                 AND TOXICITY


                 OF CHEMICALS


                 FTHROUGHN



                          by

                  J. Dorigan, B. Fuller and R. Duffy

                     The Mitre Corporation
                       Metrek Division
                     Westgate Research Park
                     McLean, Virginia 22101


                     Contract No. 68-02-1495


                       Project No. 077L


                 EPA Project Officer: David R. Patrick



                       Prepared for

                ENVIRONMENTAL PROTECTION AGENCY
                 Office of Air and Waste Management
                Office of Air Quality Planning and Standards
                Research Triangle Park, North Carolina 27711

                       October 1976

-------
                           PREFACE

     A program is being developed by the Emission Standards and
Engineering Division of the U.S. Environmental  Protection Agency to
determine the extent and environmental effects of atmospheric industrial
emissions of synthetic organic chemicals.  As part of the initial effort,
EPA requested that the MITRE Corporation, METREK Division, devise a
system for identifying those chemicals that may be released to the
atmosphere from chemical manufacturing plants and whose health effects
have been documented.  To address this need, three general categories of
information for each compound to be evaluated were deemed directly
relevant:
     (1) the quantity of the compound produced;
     (.2) the potential for atmospheric release from chemical manu-
         facturing plants, and
     C3) the toxicological effects of the compounds.
The results of this study are presented  in the accompanying report
"Preliminary Scoring of Organic Air Pollutants."
     The following dossiers were prepared for each of the 637 compounds
under consideration in an attempt to collate the pertinent data  for
subsequent evaluation.

-------
                          TABLE OF CONTENTS
Ferbam
Ferrocene
Fluometuron
Folex
Folpet
Formaldehyde
Fo rmamide
Formic acid
Fumaric acid
Furfural
Furfuryl alcohol
Glycerol
Glycerol monostearate
Glycidol
Glycine
Glyoxal
Guanidine
Guthion
Heptachlor
Heptene
Herban
Hexachloroethane
Hexachloronaphthalene
Hexalene glycol
Hexamethylenetetramine
Hexanediamine
Hydrogen, cyanide
Hydroquihone
Indene
Isoamyl alcohol
Isobutyl acetate
Isobutyl alcohol
Isobutylaldehyde
Isobutylene
Isobutyric acid
Isodecyl alcohol
Isooctyl alcohol
Isooctylphenol, ethoxylated
Isophorone
Isophthalic acid
Isoprene
Isopropyl acetate
Isopropyl alcohol
Isopropylamine
AIII-2
AIII-4
AIII-6
AIII-8
AIII-10
AIII-12
AIII-14
AIII-16
AIII-18
All1-20
AIII-22
AIII-24
All1-26
AIII-28
AIII-30
AIII-32
AIII-34
AIII-36
AIII-38
AIII-40
AIII-42
AIII-44
AIII-46
AIII-48
AIII-50
AIII-52
AIII-54
AIII-56
AIII-58
AIII-60
AIII-62
AIII-64
AIII-66
AIII-68
AIII-70
AIII-72
AIII-74
AIII-76
AIII-78
AIII-80
AIII-82
AIII-84
AIII-86
AIII-88
                                   ill

-------
                   TABLE OF CONTENTS (Continued)
Isopropy1 chloride
Isopropyl ether
o-Isopropylphenol
p-Isopropylphenol
Ketene
Ligninsulfonic acid,
Ligninsulfonic acid,
Ligninsulfonic acid,
Ligninsulfonic acid,
Lindane
Linuron
Magenta
Malathion
Maleic acid
Maleic anhydride
Maleic hydrazide
Malic acid
Melamine
Mesitylene
Mesityl oxide
Methacrylic acid
Methacrylonitrile
Methallyl alcohol
Methallyl chloride
Methane
Methanearsonic acid
Methomyl
Methoxychlor
Methoxyethano1
Methyl acetate
Methyl acetoacetate
Methylal
Methyl alcohol
Methylamine
Methylamyl acetate
Methylamyl alcohol
Methylaniline
Methylbenzyl alcohol
Methyl bromide
Methyl butyl ketone
Methylbutynol
Methyl cellulose
Methyl chloride
Methylcholanthrene
ammonium salt
calcium salt
ferrochrome salt
sodium salt
AI11-90
AIII-92
AIII-94
AIII-96
AIII-98
AIII-100
AIII-102
AIII-104
AIII-106
AIII-108
AIII-110
AIII-112
AIII-114
AIII-116
AIII-118
AIII-120
AIII-122
AIII-124
AIII-126
AIII-128
AIII-130
AIII-132
AIII-134
AIII-136
AIII-138
AIII-140
AIII-142
AIII-144
AI 11-146
AIII-148
AIII-150
AIII-152
AIII-154
AIII-156
AIII-158
AIII-160
AIII-162
AIII-164
AIII-166
AIII-168
AIII-170
All1-172
AIII-174
AIII-176
                                  IV

-------
                    TABLE OF CONTENTS (Continued)
Methylcyclohexane
Methylcyclohexanol
Methylcyclohexanone
4,4'-Methylenebis (2-chloroaniline)
Methylene chloride
Methylenedianiline
Me thyIdioxolane
Methyl ethyl ketone
Methyl formate
Methylhydrazine
Methyl iodide
Methyl isoamyl ketone
Methyl isobutyl ketone
Methyl isocyanate
Methyl mercaptan
Methyl methacrylate
Methylnaphthalene
N-Methyl-N'-nitro-N-nitrosoguaindine
Methyl parathion
Methylpentanediol
Methylpentynol
Methylphenylcarbinol
a-Methylstyrene
Mevinphos
Mirex
Monosodium glutamate
Morpholine
MSMA
Nab am
Naled
Naphtha (solvent)
Naphthalene
a-Naphthalenesulfonic acid
3-Naphthalenesulfonic acid
a-Naphthol
B-Naphthol
1-Naphthylamine
2-Naphthylamine
Naptalam
Neopentanoic acid
Nitrilotriacetic acid, trisodium salt
p-Nitroaniline
Nitroanisole
Nitrobenzene
AIII-178
AIII-180
AIII-182
AIII-184
AIII-186
AIII-188
AIII-190
AllI-192
AIII-194
AIII-196
AIII-198
AIII-200
AIII-202
AIII-204
AIII-206
AIII-208
AIII-210
AIII-212
AIII-214
A1II-216
AIII-218
AIII-220
AIII-222
A1II-224
AIII-226
AI11-228
AIII-230
AIII-232
AIII-234
AIII-236
AIII-238
AIII-240
AIII-242
AHI-244
AIII-246
A1II-248
AIII-250
AIII-252
AIII-254
AIII-256
AIII-258
AIII-260
A1II-262
A1II-264
                                 v

-------
                   TABLE OF CONTENTS (Continued)
p-Nitrobenzoic acid
Nitrocellulose
Nitroethane
Nitroglycerine
Nitromethane
m-Ni trophenol
o-Nitrophenol
p-Nitrophenol
1-Nitropropane
2-Nitropropane
N-Nitrosodiethylamine
N-Nitrosodimethylamine
Nitrosoethylurea
Nitrosomethylurea
m-Nitrotoluene
o-Nitrotoluene
p-Nitrotoluene
Nonene
Nonyl phenol
 Page

AIII-266
AIII-268
AIII-270
AI11-272
AIII-274
AIII-276
AIII-278
AllI-2 80
AIII-282
AIII-284
AIII-286
AIII-288
AIII-290
AIII-292
AIII-294
All I-2 96
AIII-298
AIII-300
AIII-302
                                vi

-------
                 APPENDIX III









CHEMISTRY, PRODUCTION AND TOXICITY OF SELECTED




         SYNTHETIC ORGANIC CHEMICALS
                     AIII-1

-------
Ferbam
                                     CHEMICAL NAME
    CAS Number:    301-05-3

    Chemical Name:     Ferbam

    Synonyms:   Dimethyldithiocarbamic acid
                Ferric dimethyl dithiocarbamate
                Tris (dimethyldithiocarbamato) iron
    Molecular
      Formula:   C9H18FeN3S6
    Structure:
                    CH,
                     CH,
N-C-S
    Chemical Properties

       Molecular Weight:   416.5

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
              Fe
                        Physical State:   Solid

                        Vapor Density:

                        Melting Point:   Decomposes > 180C

                        Solubility:   Slightly (H2O)
     Safety Hazard:
                                          .  All1-2

-------
                                                                                  Ferbam
                               PRODUCTION DATA
Annual U.S.
 Production:  2.3 x 106 Ibs. (1967)

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
Consumption:

Fraction of Pro-
 duction Lost:  0.015
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal
      LDSO               4000 mg/kg            rat
                         2700 mg/kg            rat
      LDLo                 63 mg/kg            mouse
                         2000 mg/kg            rabbit
                          200 mg/kg            rabbit
                          450 mg/kg            guinea pig
                          700 mg/kg            guinea pig

Non-lethal Acute Effects:
      Irritant to eyes and mucous membranes
                     Route
                   oral
                   intrapeiitoneal
                   intraperitoneal
                   oral
                   intraperitoneal
                   oral
                   intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 15 mg/m3



   Carcinogenicity: Recognized carcinogen
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
TLV:  15 mg/m3
                                       AIII-3

-------
Ferrocene
                                      CHEMICAL  NAME
    CAS Number:   102-54-5

    Chemical Name:    Ferrocene

    Synonyms:  Dicyclopentadiene iron
    Molecular
      Formula:   Ci0H10Fe
    Structure:
                    Fe
    Chemical Properties

       Molecular Weight:   186.0

       Vapor Pressure:

       Boiling Point:  Sublimes

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
            Resistant to ultraviolet light
Physical State:   Solid

Vapor Density:

Melting Point:   173 to 174C

Solubility:   Insoluble (H2O)
    Safety Hazard:  Fire-moderate
                   Disaster hazard-dangeroustoxic fumes
                                             All1-4

-------
                                                                            Ferrocene
                              PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDSO              1320mg/kg           rat                oral
                         500mg/kg           rat                intraperitoneal
                        1550mg/kg           mouse              oral
                         335 mg/kg           mouse              intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                      AIII-5

-------
Fluometuron
                                     CHEMICAL NAME


    CAS Number:    2164-17-2

    Chemical Name:    l,l-Dimethyl-3-(a,a,a-trifluoro-m-tolyl) urea

    Synonyms:   Fluometuron
    Molecular
      Formula:
    Structure:
                    CF,
                                O
                                       CH,
                                       CH,
     Chemical Properties

       Molecular Weight:  232.23

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:  Solid

Vapor Density:

Melting Point:   163 to 164.5C

Solubility:  90ppm(H2O)
     Safety Hazard:
                                            AIII-6

-------
                                                                        Fluometuron
Annual U.S.
 Production:   4 x 106 Ibs. (1971)
                              PRODUCTION DATA
                                Consumption:
Fraction of
 Dispersion:
1.0
             Fraction of Pro-
              duction Lost: 0.015
Release Rate (million Ibs/yr): 4
Acute Toxicity
     LDSO
             Dosage
           89 mg/kg
          900 mg/kg.
TOXICITY DATA

              Animal
            rat
            mouse
Non-lethal Acute Effects:
     Emesis
     Coma
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
      Depression
  Route
oral
oral
                                TLV:
                                      AIII-7

-------
Folex
                                      CHEMICAL  NAME


    CAS Number:   150-50-5

    Chemical Name:    Phosphorotrithious acid, tributyl ester

    Synonyms:   Folex
                S,S,S-Tributyl phosphorotiithioite

    Molecular
      Formula:   Ci2H27PS3
                 CH3(CH2)3-S  ^
    Structure:                    , P - S (CH,) CH,
                 CH3(CH2)3-S           2    3
    Chemical Properties

       Molecular Weight:   298.54

       Vapor Pressure:

       Boiling Point:   115 to 134Cat0.08mm

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:   Liquid

Vapor Density:

Melting Point:

Solubility:  Insoluble (H2O)
    Safety Hazard:
                                             AllI-8

-------
                                                                                    Folex


                               PRODUCTION DATA
Annual U.S.
 Production:3 x 106 Ibs. (1971)                  Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:    1-0                                duction Lost: 0.015

Release Rats (million Ibs/yr):  3
                                 TOXICITY DATA

Acute Toxicity               Dosage              Animal               Route
      LD50                910mg/kg             rat                 oral
                          615 mg/kg             rat                 skin
                           76 mg/kg             rat                 intraperitoneal
                          350 mg/kg             rat                 unreported
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                       AIII-9

-------
Folpet

                                      CHEMICAL  NAME

    CAS Number:   133-07-3
    Chemical Name:    Phthalimide-N[(trichloromethyl)thio]
    Synonyms:  Folpet
                Phaltan
    Molecular
      Formula:   C9H4Cl3NO2S
    Structure:
     Chemical Properties
       Molecular Weight:   296.6                        Physical State:  Solid
       Vapor Pressure:                                  Vapor Density:
       Boiling Point:                                   Melting Point:   177C
       Density:                                        Solubility:   Nearly insoluble (H26)
       Octanol/Water Parti-
         tion Coefficient:   2.85
     Environmental Persistence
       BOD:
       Atmospheric Reactivity:
     Safety Hazard:   Disaster hazard-dangerousemits highly toxic fumes of SOX and NOX
                                             AllI-10

-------
                                                                                    Folpet
Annual U.S.
 Production:   2 x 106 Ibs. (1971)

Fraction of
 Dispersion:    Estimated at 1.0

Release Rate (million Ibs/yr): 2.0
                               PRODUCTION DATA
                      Consumption:
                      Fraction of Pro-
                       duction Lost:  0.015
Acute Toxicity
     LDjo

Non-lethal Acute Effects:
     TDLo
         TQXICITY DATA


lO.OOOmg/kg
 Animal
rat
  500 mg/kg (7 days)    pregnant hamster
  Route
oral
                   oral
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:  Teratogenic

   Other Chronic Effects:
                      TLV:
                                       AllI-11

-------
Formaldehyde
                                    CHEMICAL  NAME


    CAS Number:   50-00-0

    Chemical Name:    Formaldehyde (Commercial solutions 37%-50%)

    Synonyms:   Methanal
                Methyl aldehyde
                Formalin
    Molecular
      Formula:   CH2O



                   O
                   II
    Structure:    H - C - H
    Chemical Properties

       Molecular Weight:   30.03                      Physical State:  Gas or Liquid

       Vapor Pressure:  1946.67 mm at 25C             Vapor Density:

       Boiling Point:   -21Cat760mm               Melting Point:   -92C

       Density:  0.815 at 20C/4C                    Solubility:    Soluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:   -0.96

    Environmental Persistence

       BOD:    30% of  theoretical after 5 days at 20C at 10 mg/ml
                Total theoretical oxygen demand -1.1 gm/gm
       Atmospheric Reactivity:
             Activity toward  03:   No data
                           RO2: 1%= 10 days
                           OH:   tM= 1.2 hours
    Safety Hazard:   Fire-moderate
                   Explosion-moderate
                                           AIII-12

-------
                                                                         Formaldehyde
                                PRODUCTION DATA
Annual U.S.
 Production:   5651.8 x 106 Ibs.

Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr):    52.7
                      Consumption:  5622.8 x 106 Ibs.

                      Fraction of Pro-
                        duction Lost: 0.015
                                  TOXICITY DATA
Acute Toxicity
     LD50


     LDLo
      LCLo
Non-lethal Acute Effects:
      Irritant
         TCLo
      Conjunctivitis
      Dermatitis
  Dosage
 420 mg/kg
 300 mg/kg
 260 mg/kg
  16 mg/kg
  36 mg/kg
 550 mg/kg
 240 mg/kg
 Animal
rat
mouse
guinea pig
mouse
human
dog
rabbit
  Route
subcutaneous
subcutaneous
oral
intraperitoneal
oral
subcutaneous
subcutaneous
 900 mg/kg (2 hours)     mouse
 820 mg/kg (8 hours)     cat
                    inhalation
                    inhalation
 13.8 ppm
human
inhalation
Chronic Toxicity
   U.S. Occupational Standard:  (air) "TWA 3 ppm
                            Ceiling limit 5 ppm
                            Peak exposure 10 ppm (30 minutes once in 8 hours)
   Carcinogenicity:
      Spindle cell sarcomas
      Neoplastic effects
        TDLo	
   Mutagenicity:

   Teratogenicity:
                      rats

1300 mg/kg (65 weeks)   rat
                    injections

                    subcutaneous
                      TLV:
            3 ppm
   Other Chronic Effects:
      Irritates eyes, respiratory tract and skin as low as 0.3 ppm
                                        AIII-13

-------
Forma mide
                                     CHEMICAL  NAME
    CAS Number:    75-12-7

    Chemical Name:     Formamide

    Synonyms:   Methaneamide
    Molecular
      Formula:   CH3NO
                    O
                    II
    Structure:    H - C - NH2
    Chemical Properties

       Molecular Weight:   45.04

       Vapor Pressure:  1 mm at 70.5C
Physical State:  Liquid

Vapor Density:
       Boiling Point:    210.7C (decomposes starting at    Melting Point:   2.55C
                      about 180C)
       Density:  1.134 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:   -1-67

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Solubility:    Infinite (H2O)
    Safety Hazard:   Fire-moderate
                   Disaster hazard-moderate-toxic fumes
                                            AllI-14

-------
                                                                           For mam id e


                               PRODUCTION DATA
Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
     LDSo              2539mg/kg            guinea pig           intramuscular

Non-lethal Acute Effects:
     Local irritant
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 20 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:
     TDL0    6 gm/kg  pregnant rat intraperitoneal
   Other Chronic Effects:
                                       AIII-15

-------
Formic acid
                                      CHEMICAL NAME
    CAS Number:   64-18-6

    Chemical Name:    Formic acid

    Synonyms:  Methanoic acid
                Hydrogen carboxylic acid

    Molecular
      Formula:  CH2O2
                   O
                   II
    Structure:  H - C - OH
     Chemical Properties

       Molecular Weight:   46.3                        Physical State:   Liquid

       Vapor Pressure:  42.38 mm at 25C               Vapor Density:  1.59

       Boiling Point:   100.8C                       Melting Point:   8.3C

       Density:   1.2201 at 20C/4C                   Solubility:   Soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:   -0.73

     Environmental Persistence

       BOD:     68% of theoretical after 20 days at 20C at 10 mg/ml
                 Total theoretical oxygen demand = 0.35 gm/gm
       Atmospheric Reactivity:
     Safety Hazard:  Fire-moderate
                                            AI11-16

-------
                                                                           Formic acid
                               PRODUCTION DATA
Annual U.S.
 Production:   46.9 x 106 Ibs.

Fraction of
 Dispersion:    0.50

Release Rate (million Ibs/yr):  24.1
                      Consumption:  46.9 x 106 Ibs.

                      Fraction of Pro-
                       duction Lost: 0.015
                                 TOXICITY DATA
Acute Toxicity
     LDSO
  Dosage
1210mg/kg
llOOmg/kg
 145 mg/kg
 Animal
rat
mouse
mouse
  Route
oral
oral
intravenous
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:  5ppm
Moderate effects as an irritant or upon inhalation
Severe effects following ingestion
Nausea-15 ppm
                                       AIII-17

-------
Fumaric acid
                                      CHEMICAL  NAME
    CAS Number:   110-17-8

    Chemical Name:    Fumaric acid

    Synonyms:  trans-Butenedioic acid
                Boletic acid
                Lichenic acid
    Molecular
      Formula:  C4H4O4
                            Allomaleic acid
               O
    Structure:
   H

C~=C
J_
H
                                  O
                                 OH
     Chemical Properties

       Molecular Weight:   116.1

       Vapor Pressure:

       Boiling Point:   165C at 1.7 mm (sublimes)

       Density:   1.635 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:   0.56

     Environmental Persistence

       BOD:     82% of theoretical at 20 after 10 days
                 Total theoretical oxygen demand = 0.83 gm/gm
       Atmospheric Reactivity:
                               Physical State:   Solid

                               Vapor Density:

                               Melting Point:   287C

                               Solubility:   Slightly (H2O)
     Safety Hazard:   Fire-slight
                                             AIII-18

-------
                                                                       Fumaric  acid
                              PRODUCTION DATAj
                 t
Annual U.S.
 Production:   42 x 106 Ibs. (1974)                 Consumption:  42 x 10b Ibs.

Fraction of   '                                 Fraction of Pro-
"'Dispersion:   0.30                             duction Lost:  0.015
Release Rate (million Ibs/yr): 16.2
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                      AllI-19

-------
Furfural
                                     CHEMICAL NAME
    CAS Number:   98-01-1

    Chemical Name:    2-Furaldehyde

    Synonyms:.  2-Futancaibonal
                Furfural
                Fural
    Molecular
      Formula:   CsH4O2
                                     Furale
    Structure:
                          \\
                        o


Chemical Properties

   Molecular Weight:   96.1

   Vapor Pressure:  2.08mmat25C

   Boiling Point:   161.7Cat 764mm

   Density:   1.161 at 20C/20C

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence.

   BOD:

   Atmospheric Reactivity:
                                                    Physical State:   Liquid

                                                    Vapor Density:  3.31

                                                    Melting Point:   -38.7C

                                                    Solubility:   Slightly (H2O)
     Safety Hazard:  Fire-moderate
                   Explosionmoderate
                                            AIII-20

-------
                                                                                 Furfural
                               PRODUCTION DATA
Annual U.S.
 Production:   149.6 x 106 Ibs. (1974)

Fraction of
 Dispersion:    0.01

Release Rate (million Ibs/yr):
                           Consumption:   153 x 106 Ibs.

                           Fraction of Pro-
                             duction Lost: 0.015
Acute Toxicity
     LD50
      LCLo
                                 TOXICITY DATA
        Dosage
      127 mg/kg
      425 mg/kg
     2300 mg/kg
      928 mg/kg
      541 mg/kg
      153 ppm (4 hours)
 Animal
rat
mouse
dog
rabbit
guinea pig
rat
  Route
oral
oral
oral
oral
oral
inhalation
Non-lethal Acute Effects:
      Irritation to eyes, nose and throat
          TD
             Lo
600 gm/nr (eye)
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 5 ppm (skin)



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                           TLV:
                                         AIII-21

-------
FurfuryI alcohol
                                     CHEMICAL  NAME
    CAS Number:   98-00-0

    Chemical Name:    Furfury 1 alcohol

    Synonyms:   2-Furyl carbinol
                (2-Furyl) methanol

    Molecular
      Formula:   CSH6O2
    Structure:
                      CH2OH
     Chemical Properties

       Molecular Weight:   98.1

       Vapor Pressure:  1 mm at 31.8C

       Boiling Point:    171C at 750mm

       Density:   1.129 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:  Fire-moderate
                   Explosion-moderate
Physical State:  Liquid

Vapor Density:  3.37

Melting Point:

Solubility:    Infinite (H2O)
                                            AllI-22

-------
                                                                     Furf uryl alcohol
                               PRODUCTION DATA
Annual U.S.
 Production:  Estimated as 70 x 106 Ibs. (1974)       Consumption: 4 x 106 Ibs. (1964)
Fraction of
  Dispersion:

Release Rate (million Ibs/yr):
                      Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
  Dosage
275 mg/kg
 40 mg/kg
650 mg/kg
233 ppm (4 hours)
Non-lethal Acute Effects:
      Irritation to eyes
      Nausea
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 50 ppm


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
mouse
rabbit
rat
                      TLV: 50 ppm
  Route
oral
oral
intravenous
inhalation
                                      AIII-23

-------
Glycerol
     CAS Number:   56-81-5

     Chemical Name:    Glycerol

     Synonyms:   1,2,3-Propane triol
                 Glycerin
                 Glycyl alcohol
     Molecular
      Formula:   C3H8O3
                                      CHEMICAL NAME
    Structure:
CH2 - OH

CH-OH
 I
CH2 - OH
     Chemical Properties

        Molecular Weight:   92.09

        Vapor Pressure:  4.99 x 10"4 at 25C
        Boiling Point:   290C (decomposes)

        Density:   1-2653 at 20C/4C

        Octanol/Water Parti-
         tion Coefficient:   -2.66

     Environmental Persistence
        BOD:     74% of theoretical for 10 days at 2 mg/1
                 Total theoretical oxygen demand = 1.37 gm/gm

        Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   Fire-dangerous
                                  Physical State:  Liquid

                                  Vapor Density:  3.17

                                  Melting Point:    20C

                                  Solubility:    Soluble (H2O)
                                            AI11-24

-------
                                                                                 Glycerol


                               PRODUCTION DATA

Annual U.S.
 Production:   199.2 x 106 Ibs.                    Consumption:  144.1 x 106 Ibs.

Fraction of                                      Fraction of Pro-
 Dispersion:    0.60                               duction Lost: 0.015

Release Rate (million Ibs/yr): 89.4



                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LDSO               7750mg/kg            guinea pig           oral

Non-lethal Acute Effects:
      Irritant to eyes and respiratory tract
      Nausea and vomiting
      Convulsions and paralysis
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                       AIII-25

-------
Glycerol  monostearate
                                    CHEMICAL  NAME
    CAS Number:   1319-95-5

    Chemical Name:   Monosteaiin

    Synonyms:  Glyceryl monostearate
               Glycerol monostearate
               CMS
    Molecular
      Formula:  C2iH42O4
                CH2OH	

    Structure:    CH OH
                I
                CH2O - C - (CH2)16 CH3

                       O

    Chemical Properties

       Molecular Weight:  358.63                     Physical State:  Solid

       Vapor Pressure:                               Vapor Density:

       Boiling Point:   58to59C                     Melting Point:  74C

       Density:  0.97                               Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence.

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                           AllI-26

-------
                                                        Glycerol monostearate
                             PRODUCTION DATA

Annual U.S.
 Production:   27.2 x 106 Ibs.                    Consumption:  27.2 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:   1-0                               duction Lost:  0.03

Release Rate (million Ibs/yr): 28.0
                               TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
                       200 mg/kg             mouse             intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AIII-27

-------
Glycidol


                                     CHEMICAL NAME


     CAS Number:   556-52-5

     Chemical Name:   2,3 - Epoxy - 1 - propanol

     Synonyms:  Glycide
                Glycidol

     Molecular
      Formula:  C3H6O2
                         O
                        / \
    Structure:      H - c - C - OH
                       ]_  \
                       H  H
     Chemical Properties

        Molecular Weight:   74.09                       Physical State:  Liquid

        Vapor Pressure:                                Vapor Density:

        Boiling Point:   167C (decomposes)             Melting Point:
                                               /
        Density:  1.165 at 0C/4C                      Solubility:   Infinite (H2O)

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
     Safety Hazard:
                                            AI11-28

-------
                                                                                 Glycidol
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                  TOXICITY DATA
Acute Toxicity
      LC50
 850 mg/kg
 450 mg/kg
1980 mg/kg
 580 ppm (8 hours)
 450 ppm (4 hours)
Non-lethal Acute Effects:
      Nervous excitation followed by depression
      Irritant to eyes and respiratory tract
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 50 ppm



   Carcinogenicity:
 Animal
rat
mouse
rabbit
rat
mouse
  Route
oral
oral
skin
inhalation
inhalation
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV: 50ppm
                                       AIII-29

-------
Glycine
    CAS Number:  56-40-6

    Chemical Name:    Glycine

    Synonyms:   Aminoacetic acid
                Glycocoll

    Molecular
      Formula:   C2HSN02
                                     CHEMICAL NAME
    Structure:   H2N -  CH2 -  C
                                   O
                                   OH
     Chemical Properties

       Molecular Weight:   75.07

       Vapor Pressure:

       Boiling Point:    (decomposes)

       Density:   1.1607

       Octanol/Water Parti-
         tion Coefficient:   -3.03

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:  Solid

Vapor Density:

Melting Point:  232 to 236C (decomposes)

Solubility:    Soluble (H2O)
     Safety Hazard:
                                           AllI-30

-------
                                                                              Glycine

                              PRODUCTION DATA
Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                        .            duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITYDATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogehicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AIII-31

-------
Glyoxal
                                      CHEMICAL  NAME
     CAS Number:    107-22-2

     Chemical Name:    Glyoxal

     Synonyms:   Ethanedial
                 Oxalaldehyde
                 Biformyl
     Molecular
      Formula:
Structure:
                    O
                              O
                     \\
                      C -  C
                 H
     Chemical Properties

        Molecular Weight:    58.02

        Vapor Pressure:   <10 mm at 25C

        Boiling Point:    50.4C

        Density:   1-26 at 20C/4C

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOO:

        Atmospheric Reactivity:
                                                 Physical State:   Solid or Liquid

                                                 Vapor Density:

                                                 Melting Point:    15C

                                                 Solubility:    Very soluble (H2O)
     Safety Hazard:   Fire-slight
                                           .  AIII-32

-------
                                                                                Glyoxal

                               PRODUCTION DATA
Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
     LDso               200 mg/kg             mouse              intraperitoneal
                         760 mg/kg             guinea pig           oral
                         100 mg/kg             rat                 oral

Non-lethal Acute Effects:
     Local irritant to skin and mucous membranes
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AIII-33

-------
Guanidine
                                     CHEMICAL  NAME
    CAS Number:    113-00-8

    Chemical Name:     Guanidine

    Synonyms:   Amino methanamidine
                Carbamamidine

    Molecular
      Formula:   CHSN3
    Structure:
NH
II
C
                      H2N      NH2
     Chemical Properties

       Molecular Weight:   59.07

       Vapor Pressure:

       Boiling Point:    160C (decomposes)

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
                         Physical State:   Solid

                         Vapor Density:

                         Melting Point:   ca. 50C

                         Solubility:   Very soluble (H2O)
                                            AIII-34

-------
                                                                              Guanidine
                               PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                       duction Lost:

Release Rate (million Ibs/yr):
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
                          175 mg/kg             rat                 intraperitoneal
                          300 mg/kg             mouse              subcutaneous
                          200 mg/kg            . dog.                subcutaneous
                          100 mg/kg             cat                 intraperitoneal
                          200 mg/kg             cat                 subcutaneous
                          5 00 mg/kg             rabbit              oral
                          500 mg/kg             rabbit              subcutaneous
                         1500 mg/kg             guinea pig           intraperitoneal
                          100 mg/kg             guinea pig           subcutaneous
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                       AIII-35

-------
Guthion
                                       CHEMICAL  NAME
     CAS Number:    86-50-0

     Chemical Name:     Phosphorodithioic acid, O-O, dimethyl ester, S-ester with 3-(mercaptomethyl)-l,2,3-
                       benzotriazin-4(3H)-one
     Synonyms:   Guthion
                 O-O-Dimethyl-S-(4-oxo-l,2,3-benzotriazin-3-(4H)-ylmethyl)-phosphorodithioate
                 Benzotiiazinedithiophosphoric acid, dimethyoxy ester
                 N-Methylbenzamide, dimethyldiphosphoric acid ester
     Molecular  \
      Formula:    Ci0Hj2N3O3PS2

                                            o
                                            II
                          s               ^
     Structure:    uc,O - P - S - CH, - N
                          '    H         '
                             2 5        N _
     Chemical Properties

        Molecular Weight:   317.34

        Vapor Pressure:

        Boiling Point:   Decomposes at elevated
                      temperatures
        Density:  1.44  "

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOO:

        Atmospheric Reactivity:
Physical State:   Solid

Vapor Density:

Melting Point:   74C

Solubility:   Slightly (H2O)
            (29 ppm at 25 C)
     Safety Hazard:
                                              AIII-36

-------
                                                                                  Guthion
Annual U.S.
 Production:

Fraction of
 Dispersion:
4.0 x 10 Ibs.
1.0
                               PRODUCTION DATA
Consumption:

Fraction of Pro-
 duction Lost:
                                                 0.015
Release Rate (million Ibs/yr): 4.0
Acute Toxicity
      LDSO
            16 mg/kg
           300 mg/kg
            15 mg/kg
             4 mg/kg
            80 mg/kg
           277 mg/kg
             8 mg/kg
             5 mg/kg
                                  TOXICITY DATA
 Animal
rat
rat
lat
mouse
guinea pig
chicken
wild bird
mouse
  Route
oral
skin
unreported
intraperitoneal
oral
oral
oral
oral
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 200 Mg/m3 (skin)
      EPA-Farm worker field reentry standard
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:    Cholinesterase inhibition
                                        AIII-37

-------
Heptachlor
                                      CHEMICAL  NAME
    CAS Number:   76-44-8

    Chemical Name:    M.S.ej.S'.S-Heptachloro-SMJJa-
                      tetrahydro-4,7-methanoindene
    Synonyms:   Heptachlor
                 3,4,5,6,7,8,9-Heptachlorodicyclopentadiene

    Molecular
      Formula:   C  HCl-
    Structure:
                Cl
                      Cl    Cl
Chemical Properties

   Molecular Weight:   373.32

   Vapor Pressure:

   Boiling Point:

   Density:  1.57 to 1.59

   Octanol/Water Parti-
    tion Coefficient:   5.05

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
                                                      Physical State:   Solid

                                                      Vapor Density:

                                                      Melting Point:   95 to 96C

                                                      Solubility:    Insoluble (H2O)
     Safety Hazard:   Disaster hazard-dangerous, decomposition to toxic fumes
                                             AllI-38

-------
                                                                             Heptachlor
                               PRODUCTION DATA
Annual U.S.
 Production:

Fraction of
 Dispersion:
6 x 106 Ibs.
1.0
Consumption:

Fraction of Pro-
 duction Lost:  0.01
Release Rate (million Ibs/yr): 6.0
                                  TOXICITY DATA
Acute Toxicity
      LDSO
 Non-lethal Acute Effects:
      Convulsions
      Kidney damage
             Dosage
             40 mg/kg
            195 mg/kg
             27 mg/kg
           2000 mg/kg
            116 mg/kg
             62 mg/kg
             25 mg/kg
             40 mg/kg
 Animal
rat
rat
rat
rabbit
guinea pig
chicken
mouse
mouse
  Route
oral
skin
intraperitoneal
skin
oral
oral
oral
intravenous
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 500 Mg/m3 (skin)



   Carcinogenicity:
       Potential carcinogen according to EPA

   Mutagenicity:

   Teratogenicity:                                f LV:  0.5 mg/m3

   Other Chronic Effects:
                                       AllI-39

-------
Heptene
                                       CHEMICAL  NAME
     CAS Number:   cis: 7642-10-6
                   trans: 14686-14-7
     Chemical Name:    cis: (Z)-3-Heptene
                      trans: (E)-S-Heptene
     Synonyms:  l-Ethyl-2-propyl ethylene
                3-Heptene
                3-Heptylene
     Molecular
      Formula:  C?H14
    Structure:
              CH3
                     CH
                                     cis
                                                  CH3
                                                         CH,
                                                                    H
                                                                 rvt
                                                                 CH2
                                                                        C  = C
                                                                                   CH,
                                                                                          CHh
                                                                                 H
                                                                           trans
     Chemical Properties

        Molecular Weight:  98.18

        Vapor Pressure: 48.24 mm at 25C

        Boiling Point:   96C at 760 mm (cis)
                      95.67C at 760 mm (trans)
        Density:  0.7030 at 20C/4C (cis)
                0.6981 at 20C/4C (trans)
        Octanol/Water Parti-
         tion Coefficient:
Physical State:  Liquid

Vapor Density: 3.38

Melting Point: -136.63C (trans)

Solubility:   Insoluble (H2O)
     Environmental Persistence

        BOD:

        Atmospheric Reactivity:   Reacts vigorously with oxidizing materials
     Safety Hazard:  Fire-dangerous
                                              AIII-40

-------
                                                                                Heptene


                               PRODUCTION DATA
Annual U.S.
 Production:   114xl06lbs.                      Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                      duction Lost: 0.015

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
        Potential carcinogen according to EPA (unspecified isomer)

   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:    Minor irritant
                         Minor effects upon ingestion or inhalation
                                        AI11-41

-------
Herban
                                      CHEMICAL  NAME


    CAS Number:    2163-79-3

    Chemical Name:    3-(Hexahydro-4,7-methanoindah-5-yl)-l,l-dimethylurea

    Synonyms:   Heiban
                Norea
    Molecular
      Formula:
    Structure:
    Chemical Properties

       Molecular Weight:   222.3

       Vapor Pressure:   Insignificant

       Boiling Point:    Decomposes

       Density:   1.162 at 25C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:  Solid

Vapor Density:

Melting Point:  168 to 169C

Solubility:   Very slightly soluble (H2O)
    Safety Hazard:
                                             AIII-42

-------
Annual U.S.
 Production:

Fraction of
 Dispersion:
2.0xl06lbs.
1.0
Release Rate (million Ibs/yr):  2.0
                                                                                Herban
                              PRODUCTION DATA
Consumption:
Fraction of Pro-
 duction Lost:  0.015
Acute Toxicity
      LD50
                   TOXICITY DATA

                                Animal
           1470 mg/kg
           2000 mg/kg
           4600 mg/kg
           3700 mg/kg
rat
rat
mouse
dog
  Route
oral
not reported
oral
oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinqgenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                TLV:
                                      AIII-43

-------
Hexachloroethane
                                     CHEMICAL  NAME
    CAS Number:   67-72-1

    Chemical Name:    Hexachloroethane

    Synonyms:   Carbon hexachloride
                Perchloroe thane

    Molecular
      Formula:   C2C16
    Structure:   C13C - C C13
     Chemical Properties

       Molecular Weight:   236.76

       Vapor Pressure:  l mm at 32.7C

       Boiling Point:   186.6C (sublimes)

       Density:  2.091 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     E nvironmental Persistence

       BOO:

       Atmospheric Reactivity:
Physical State:  Solid

Vapor Density:

Melting Point:  185C

Sol u bil ity:    Insoluble (H2 O)
     Safety Hazard:  Explosion-slight
                   Disaster hazard-when heated to decomposition, emits phosgene
                                            AIII-44

-------
                                                                Hexachloroethane
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITV DATA

Acute Toxicity              Dosage              Animal              Route
      LCLo               325 mg/kg            dog                intravenous
                        4000 mg/kg            rabbit              subcutaneous

Non-lethal Acute Effects:
      Liver injury
      Irritant to eyes
      Mild narcosis
Chronic Toxicity

   U.S. Occupational Standard:  (air): TWA 1 ppm (skin)



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                       AIII-45

-------
Hexachloronaphthalene
                                    CHEMICAL  NAME
    CAS Number:   1335-87-1

    Chemical Name:    Hexachloronaphthalene

    Synonyms:  Chloronaphthalene


    Molecular
      Formula:  C10H2C16
    Structure:
     Chemical Properties

       Molecular Weight:   334.9

       Vapor Pressure:

       Boiling Point:   >288C

       Density:   >1.40atl49C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:
          Disaster hazard-dangerous-chlorides
Physical State:  Solid

Vapor Density:

Melting Point:   >88C

Solubility:  Insoluble (H2O)
                                           AIII-46

-------
                                                        Hexachloronaphthalene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
Consumption:

Fraction of Pro-
 duction Lost:
                                TOXICITY DATA
Acute Toxicity              Dosage
      LDLo                 llmg/kg

Non-lethal Acute Effects:
      Acneform eruptions
      Toxic narcosis of the liver
 Animal
cattle
  Route
oral
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 200 Mg/m3 (skin)



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
TLV:
                                     All1-47

-------
Hexalene glycol
                                    CHEMICAL  NAME
    CAS Number:   629-11-8

    Chemical Name:    1,6-Hexanediol
    Synonyms:
    Molecular
      Formula:
Hexalene glycol
Hexamethylene glycol
C6H,402
    Structure:    HO - CH2 - (CH2)4 - CH2OH
    Chemical Properties

       Molecular Weight:   118.18

       Vapor Pressure:  <10 mm at 25C

       Boiling Point:   250C at 760 mm

       Density:    0.967 at 0C/4*C

       Octanol/Water Parti-
        tion Coefficient:
                                 Physical State:    Liquid

                                 Vapor Density:    4.07

                                 Melting Point:     41 to 42C

                                 Solubility:   Soluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:
                                            AIII-48

-------
                                                                  Hexalene  glycol
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
        LDSO            3730 mg/kg           rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AIII-49

-------
Hexamethylenetetramine
                                     CHEMICAL NAME
    CAS Number:   100-97-0

    Chemical Name:    Hexamethylenetetramine
    Synonyms:  Methenamine
               Formamine
               Hexamine
    Molecular
      Formula:  C6H12N4
Urotropin
Metiamine
Hexaform
Ammonioformaldehyde
Formin
Hexamethyleneamine
1,3,5,7-Tetraazaadamantane
    Structure:
    Chemical Properties

       Molecular Weight:   140.19

       Vapor Pressure:

       Boiling Point:   Sublimes

       Density: 1.331 at -5C

       Octanol/Water Parti-
        tion Coefficient:   -2.34

    Environmental Persistence

       BOD:   2% of theoretical after 5 days at 20C
               Total theoretical oxygen demand = 3.19 gm/gm
       Atmospheric Reactivity:
               Activity: reacts slowly with RO? and Os
                       will react with oxidizing materials
               Activity toward OH:  tw = 9.6 hr.
               Hydrolyzes rapidly at pH 3 or 7, ti^ = 1 day

    Safety Hazard:  Fire-Moderate
              Physical State:  Solid

              Vapor Density:

              Melting Point:  285 to 295C

              Solubility:  Very soluble (666 gm/1 H2O)
                                            AIII-50

-------
                                                       Hexamethylenetetramine
                               PRODUCTION DATA
Annual U.S.
 Production:    101 x 106 Ibs.

Fraction of
 Dispersion:    0.62

Release Rate (million Ibs/yr):  63.6
                      Consumption:  101 x 106 Ibs.

                      Fraction of Pro-
                       duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
     LD50
  Dosage
9200 mg/kg
 200 mg/kg
 512 mg/kg
 Animal
rat
rat
mouse
  Route
intravenous
subcutaneous
intraperitoneal
Non-lethal Toxic Effects:
      Deimatitis
      Vesicular lesions
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
      Neoplastic effects (sarcomas and adenomas):
        TO
           Lo
 144 gm/kg (72 weeks) -   rat
                   subcutaneous
      Lymphomas                               mouse

   Mutagenicity:    Slight in mice, no details

   Teratogenicity:                               TLV:

   Other Chronic Effects:    Kidney damage
                                                                 oral
                                       AIII-51

-------
Hexanediamine
                                    CHEMICAL  NAME
    CAS Number:   124-09-4

    Chemical Name:    1,6-Hexanediamine

    Synonyms:   Hexamethylene diamine
                HMDA
    Molecular
      Formula:
    Structure:     HjN - CHjCHjCHjCHjCHjCHj - NH2
     Chemical Properties

       Molecular Weight:   116.21                      Physical State:   Solid

       Vapor Pressure:                                Vapor Density:

       Boiling Point:   205C                         Melting Point:   39-42c

       Density:                                     Solubility:   Soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   Fire-Slight
                                           AIII-52

-------
                                                                   Hexanediamine
                              PRODUCTION DATA

Annual U.S.
 Production:  613.4 x 106lbs. (1970)               Consumption:  1224.4 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:   0.01                              duction Lost: 0.015

Release Rate (million Ibs/yr):  12.8
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
Irritation of eyes and mucous membranes
Hepatitis
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     All1-53

-------
Hydrogen  cyanide
                                     CHEMICAL  NAME
    CAS Number:   74-90-8

    Chemical Name:    Hydrocyanic acid

    Synonyms:  Hydrogen cyanide
               Prussic acid

    Molecular
      Formula:  CHN
    Structure:      HC =  N
    Chemical Properties

       Molecular Weight:   27.03                       Physical State:  Liquid

       Vapor Pressure:  739.36 mm at 25C              Vapor Density:  0.932

       Boiling Point:   25.7C at 760 mm               Melting Point:   -13.3C

       Density:  0.6876 at 20C/4C                   Solubility:   Infinite (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                            AIII-54

-------
                 Hydrogen cyanide
PRODUCTION DATA
Annual U.S.
Production: 141.6 x 106
Fraction of
Dispersion:
Release Rate (million Ibs/yr):

Acute Toxicity
LDSO







LDLo






LCSO


LCLo



Ibs. (1976 capacity)



TOXICITY
Dosage
3700 jug/kg
2990 Mg/kg
11 00 Mg/kg
2700 us/kg
1570 Mg/kg
2500 Mg/kg
820 Mg/kg
1100 Mg/kg
570 Mg/kg
3 mg/kg
4 mg/kg
1700 /ug/kg
2 mg/kg
11 00 Mg/kg
100 jug/kg
544 ppm (5 months)
169 ppm (30 months)
300 ppm (3 months)
120mg/m3 (1 hours)
2500 mg/m3
600 mg/m3 (2 months)

Consumption: 365 x
Fraction of Pro-
duction Lost: 0.015

DATA
Animal
mouse
mouse
mouse
mouse
rabbit
rabbit
rabbit
rabbit
human
mouse
dog
dog
cat
cat
guinea pig
rat
mouse
dog
human
cat
rabbit

106 Ibs.




Route
oral
intraperitoneal
intravenous
intramuscular
intraperitoneal
subcutaneous
intravenous
intramuscular
oral
subcutaneous
oral
subcutaneous
oral
subcutaneous
subcutaneous
inhalation
inhalation
inhalation
inhalation
inhalation
inhalation
Protoplasmic poison-halts cellular oxidation
Chronic Toxicity



U.S. Occupational Standard: (air) TWA 10 ppm
Carcinogenicity:
Mutagenicity:
Teratogenicity:
Other Chronic Effects:



. . 	 _ . .


TLV: 10 ppm





AllI-55

-------
Hydroquinone
                                     CHEMICAL  NAME
    CAS Number:    123-31-9

    Chemical Name:    Hydroquinone

    Synonyms:   p-Hydroquinone
                1,4-Benzenediol
                Quinol
    Molecular
      Formula:   C6H6O
         Hydroquinol
    Structure:
                  HO
OH
     Chemical Properties

       Molecular Weight:   110.6

       Vapor Pressure:  1 mm at 132.4bC

       Boiling Point:    286.2C

       Density:  1.358 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:
                 Physical State:   Solid

                 Vapor Density:  3.81

                 Melting Point:

                 Solubility:   Soluble (H2O)
     Environmental Persistence

       BOD:    53% of theoretical

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
                                            AIII-56

-------
                     Hydroquinone
PRODUCTION DATA
Annual U.S.
Production: 29.7 x 106 Ibs
Fraction of
Dispersion:
Release Rate (million Ibs/yr):

(1976 capacity)




Consumption:
Fraction of Pro-
duction Lost: 0.015






TOXIGITY DATA
Acute Toxicity
LDso










LDLo



Non-lethal Acute Effects:
Dermatitis
Neurological effects
Chronic Toxicity
U.S. Occupational Standard
Carcinogenicity:
Neoplastic:
TOLo
Mutagenicity:
Teratogenicity:
Other Chronic Effects:
Dosage
370 mg/kg
170mg/kg
320 mg/kg
115 mg/kg
400 mg/kg
190 mg/kg
200 mg/kg
70 mg/kg
125 mg/kg
550 mg/kg
300 mg/kg
200 mg/kg
100 mg/kg
150 mg/kg
190 mg/kg







800 mg/kg



Animal
cat
rat
rat
rat
mouse
mouse
dog
cat
rabbit
guinea pig
pigeon
rat
mouse
guinea pig
frog

Jaundice
Nausea and vomiting




mouse

TLV: 2mg/m3

Route
oral
intraperitoneal
oral
intravenous
oral
subcutaneous
oral
oral
intraperitoneal
oral
oral
subcutaneous
intraperitoneal
intraperitoneal
parenteral







skin



AIII-57

-------
Indene
    CAS Number:   95-13-6

    Chemical Name:    lH-Indene
    Synonyms:
    Molecular
      Formula:
Indonaphthene
Indene
Inden

C9H8
                                      CHEMICAL  NAME
    Structure:
     Chemical Properties

       Molecular Weight:  116.2

       Vapor Pressure:    2.23 mm at 25C

       Boiling Point:   182.6C at 760 nun

       Density:     0.9968 at 20C/4?C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
                                  Physical State:   Liquid

                                  Vapor Density:

                                  Melting Point:     -1.8 to -1.5C

                                  Solubility:  Insoluble (H2O)
     Safety Hazard:
                                            AH 1-5 8

-------
                                                                                 Indene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                   Consumption:

                   Fraction of Pro-
                     duction Lost:
Acute Toxicity


Non-lethal Actue Effects:
        Local irritant
      TOXICITY DATA

Dosage               Animal
Route
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 10 ppm
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                   TLV:
                                       AIII-59

-------
Isoamyl  alcohol
                                     CHEMICAL  NAME
    CAS Number:   123-51-3

    Chemical Name:    Isopentyl alcohol

    Synonyms:  Isoamyl alcohol, primary
               Fusel oil

    Molecular
      Formula:  C5H12O
                       CH3
                        I
    Structure:    CH3 - CH - CH2 - CH2OH
     Chemical Properties

       Molecular Weight:  88.15

       Vapor Pressure: <10 mm at.25C

       Boiling Point:   132C

       Density:    0.813 at 15C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Isobutyl carbinol
3,3-Dimethyl-l-propanol
     Safety Hazard:  Fire-moderate
                  Explosion-slight
      Physical State:  Liquid

      Vapor Density: 3.04

      Melting Point:  -117.2C

      Solubility:   Slightly (H2O)
                                            AIII-60

-------
                                                                    Isoamyl alcohol
                              PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDSO              1300mg/kg            rat                oral
                        3970 mg/kg            rabbit              skin
     LDLo               813 mg/kg            rat                intraperitoneal
                        4250 mg/kg            rabbit              oral

Non-lethal Acute Effects:
      Irritant to eyes and skin
Chronic Toxicity

   U.S. Occupational Standard:  (aii) TWA 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               tLV:

   Other Chronic Effects:
                                      AllI-61

-------
Isobutyl  acetate
                                     CHEMICAL  NAME
    CAS Number:   110-19-0

    Chemical Name:    Acetic acid, isobutyl estei

    Synonyms:  Isobutyl acetate
    Molecular
      Formula:  C6H,2O2
                      O          CH,
                	II	       I  3
    Structure:    CH3 - C - OCH2 - CH
    Chemical Properties

       Molecular Weight:  116.2

       Vapor Pressure: 19.61 mmat 25C

       Boiling Point:   118.0C at 760 mm

       Density:  0.8712 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-dangerous
Physical State:  Liquid

Vapor Density:  4.0

Melting Point:   -99C

Solubility:   Slightly soluble (H2O)
                                           AIII-62

-------
                                                                  Isobutyl acetate
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal               Route
     LDSO               4760 mg/kg            rabbit              oral
     LC]_,0               8000 ppm (4 hours)      rat                inhalation

Non-lethal Acute Effects:
     Narcotic
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 150 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:  150 ppm

   Other Chronic Effects:
                                      AIII-63

-------
Isobutyl  alcohol
                                     CHEMICAL  NAME
    CAS Number:   78-83-1

    Chemical Name: Isobutyl alcohol

    Synonyms:  2-Methylpropanol
               Isopropyl caibinol

    Molecular
     Formula:  C4H8O
    Structure:
                      CH,
H3C - C - C - OH
                      H
    Chemical Properties

       Molecular Weight:   74.12

       Vapor Pressure: 12.6 mm at 25C

       Boiling Point:   107.9

       Density:  0.805 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:   0.97

    Environmental Persistence

       BOD:    81% of theoretical after 20 days at 20C
               Total theoretical oxygen demand = 2.6 gm/gm
       Atmospheric Reactivity:
                                    Physical State:  Liquid

                                    Vapor Density: 2-55

                                    Melting Point:  -108C

                                    Solubility:   Soluble (40 gm/lH2O)
    Safety Hazard:  Fire-moderate
                  Explosionmoderate
                  Disaster hazard-moderate-toxic fumes
                                            AIII-64

-------
                                                                    Isobutyl  alcohol
                               PRODUCTION DATA
Annual U.S.
 Production:   96.4 x 106 Ibs.

Fraction of
 Dispersion:    0.25

Release Rate (million Ibs/yr):  29.5
                      Consumption:  96.4 x 106 Ibs.

                      Fraction of Pro-
                       duction Lost: 0.015
                                 TOXICITY DATA
Acute Toxicity
      LDso

      LDLo
      LCLo

Non-lethal Acute Effects:
      Local irritant
      Conjunctivitis
      Dermatitis
  Dosage
2460 mg/kg
4240 mg/kg
3750 mg/kg
8000 ppm (4 hours)
 Animal
rat
rabbit
rabbit
rat   .
  Route
oral
skin
oral
inhalation
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:  100ppm
                                      AIII-65

-------
IsobutyI aldehyde
                                    CHEMICAL  NAME
    CAS Number:   78-84-2

    Chemical Name: Isobutyraldehyde

    Synonyms:  Isobutyl aldehyde
               2-Methyl propaldehyde
               tsobutanal
    Molecular
     Formula:  C4H8O
                 _
    Structure:   H,C - CH - C
                 3
                              _
                              O
    Chemical Properties

       Molecular Weight:   72.12

       Vapor Pressure:  210 mm at 25C

       Boiling Point:   64C

       Density:  0,794 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:  Liquid

Vapor Density:

Melting Point:   -66C

Solubility:   Insoluble (H2O)
                                            AIII-66

-------
                                                                Isobutylaldehyde
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LD50             2810mg/kg            rat                oral
                       8000 ppm (4 hours)      rat                inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:          '                    TLV:

   Other Chronic Effects:
                                     AIII-67

-------
Isobutylene
                                     CHEMICAL  NAME
    CAS Number:    115-11-7

    Chemical Name:    2-Methyl-l-propene
    Synonyms:
    Molecular
      Formula:
Isobutylene.
Isobutene
2-Methylpropene

C4H8
                      CH
                _^
    Structure:    ~H^C-~C=CH2
    Chemical Properties

       Molecular Weight:  56.1

       Vapor Pressure:  3290 mm at 40.5 C

       Boiling Point:    -6.9C

       Density:    0.600 at 20C/4C (liquid)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
                                  Physical State:    Liquid/liquified gas

                                  Vapor Density:    1.94

                                  Melting Point:     -140.35C

                                  Solubility:   Insoluble (H2O)
    Safety Hazard:
        '     Fire-dangerous
                                            AIII-68

-------
                                                                       Isobutylene

                             PRODUCTION DATA
Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                          .         duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     All1-69

-------
Isobutyric  acid
                                     CHEMICAL  NAME
    CAS Number:   79-31-2

    Chemical Name:    Isobutyric acid

    Synonyms:   2-Methylpropanoic acid
    Molecular
      Formula:  C4H8O2
                   CH3
                      \
    Structure:          CH - C -~OH~
                  _       _
                  CH3      O
    Chemical Properties

       Molecular Weight:  88.1                         Physical State:  Liquid

       Vapor Pressure: 2.67 mm at 25C                 Vapor Density:  3.04

       Boiling Point:   153.2C at 760mm               Melting Point:  -46.1C

       Density:  0.949 at 20C/4C                      Solubility:   Very Soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:  1.00

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Fire-moderate
                                           AIII-70

-------
                                                                   Isobutyric acid
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDSO               280mg/kg            rat                oral
                        500 mg/kg            rabbit             skin
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AIII-71

-------
Isodecyl alcohol
                                      CHEMICAL NAME
    CAS Number:   (Mixture)

    Chemical Name:

    Synonyms:      Isodecyl alcohol
                   Isodecanol
    Molecular
      Formula:
    Structure:    Mixture of CIQ alcohols, predominantly trimethyl heptanols
    Chemical Properties

       Molecular Weight:  158.32                      Physical State:     Liquid

       Vapor Pressure:  <.01 mm at 20C                Vapor Density:    5.5

       Boiling Point:    220.1C                        Melting Point:

       Density:    0.8395                            Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD: 32% of theoretical after 20 days at 20C
             Total theoretical oxygen demand = 3.03 gm/gm.
       Atmospheric Reactivity:
     Safety Hazard:
             Fire-moderate
                                            AIII-72

-------
                                                                 Isodecyl alcohol
                             PRODUCTION DATA

Annual U.S.
 Production:   147 x 106 Ibs.                    Consumption:     147 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:   0-5                               duction Lost:    0.15

Release Rate (million Ibs/yr):  75.7
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AIII-73

-------
Isooctyl alcohol
                                     CHEMICAL NAME
    CAS Number:     26952-21-6

    Chemical Name:      Isooctanol

    Synonyms:    Isooctanol (isomei mix)
    Molecular
      Formula:    C8H18O
    Structure:  (C7H15)CH2OH
    Chemical Properties

       Molecular Weight:     130.26

       Vapor Pressure:

       Boiling Point:  182 to 195C

       Density:   0.832 at 20C/20C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:   Liquid

Vapor Density:

Melting Point:

Solubility:
                                           AIII-74

-------
                                                                  Isooctyl alcohol
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):   15.8 (1972)
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
       LDSO              1480 mg/kg           rat                 oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AllI-75

-------
Isooctylphenol,  ethoxylated
                                     CHEMICAL NAME


    CAS Number:    11059-29-3

    Chemical Name:    26-dsooctylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-l-ol

    Synonyms:  Octylphenol polyglycol ethei
               Isooctylphenoxypolyoxyethylene ethanol

    Molecular
      Formula:  C32Hs8Oio
                     CH,
CH,
     Structure:   CH, - C - CH2 - C
                      I         I
                     CH,
CH,
                                          OC H2CH2 - O - (C2H4O)7 CH2CH2OH
     Chemical Properties

       Molecular Weight:

       Vapor Pressure:

       Boiling Point:    150C at 1 mm

       Density:    1.06at20C

       Octanol/Water Parti-
         tion Coefficient:
                     Physical State:     Liquid

                     Vapor Density:

                     Melting Point:  2 to 5C

                     Solubility:
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
          Fire-slight
          Disaster hazarddangerous-toxic fumes
                                           AIII-76

-------
                                                  Isooctylphenol, ethoxylated
                              PRODUCTION DATA
Annual U.S.
 Production:   20 x 106 Ibs.

Fraction of
 Dispersion:   1-0

Release Rate (million Ibs/yr):    20.6
                     Consumption:  20 x 106 Ibs.

                     Fraction of Pro-
                      duction Lost:    0.03
Acute Toxicity
     LD50
     for x = 3
        x = 5
        x = 8-10
        x= 12-131
        x=16
        x = 20
        TOXICITY DATA

  Dosage               Animal
4000 mg/kg
3800 mg/kg
1800 mg/kg
 900 mg/kg
2800 mg/kg
3600 mg/kg
rat
rat
rat
rat
rat
rat
        where x denotes the number of ethoxy groups
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
                    Route
oral
oral
oral
oral
oral
oral
                                     AIII-77

-------
Isophorone
                                     CHEMICAL  NAME
    CAS Number:    78-59-1

    Chemical Name:     3,5,5-Trimethyl-2-cyclohexen-l-one

    Synonyms:   Isophorone
    Molecular
      Formula:   C9H14O
                          O
    Structure:
    Chemical Properties

       Molecular Weight:   138.1

       Vapor Pressure:  1 mm at 38C

       Boiling Point:    215.2C

    .  Density:  0.9229 at 20C

       Octanol/Water Parti-
        tion Coefficient:
Physical State:  Liquid

Vapor Density:  4.77

Melting Point:  -8.1C

Solubility:    Insoluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-moderate
                                            AIII-78

-------
                                                                          Isophorone
                              PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDSO              2330mg/kg            rat                 oral

Non-lethal Acute Effects:
     Local irritant
     Lachrymation, opacity of cornea
     Kidney poisoning
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV: 25 ppm

   Other Chronic Effects:
                                      AIII-79

-------
Isophthalic acid
                                     CHEMICAL  NAME
    CAS Number:   121-91-5

    Chemical Name:     Isophthalic acid

    Synonyms:   Benzenedicarboxylic acid
                Isophthalic acid
    Molecular
      Formula:
              O  ^      OH
                  * C  "
    Structure:
                                  OH
                     \v
                             C
                                  o
     Chemical Properties

       Molecular Weight:   166.14

       Vapor Pressure:  <10 mm at 25C

       Boiling Point:    Sublimes

       Density:   !-593

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:  Fire-slight
Physical State:  Solid

Vapor Density:

Melting Point:  348C

Solubility:    Slightly soluble (H2O)
                                            AIII-80

-------
                                                                   Isophthalic acid
                              PRODUCTION DATA

Annual U.S.
 Production:   100 x 106 Ibs. (1976 capacity)         Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost: 0.015

Release Rate (million Ibs/yr):
                                TOXICITYDATA

Acute Toxicity              Dosage               Animal              Route
     LDSo              4200 mg/kg            mouse              intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AIII-81

-------
Isoprene


                                     CHEMICAL NAME


    CAS Number:   78-79-5

    Chemical Name:    Isoprene

    Synonyms:   2-Methyl-l,3-butadiene
    Molecular
      Formula:   C5H8
                        CH3

    Structure:    CH2  =  C - C  =  CH2
                          '   I
                             H
     Chemical Properties

       Molecular Weight:   68.13                       Physical State:   Liquid

       Vapor Pressure:  600.93 mm at 25C              Vapor Density:  2.35

       Boiling Point:    34Cat760mm                Melting Point:   -146C

       Density:  0.6806 at 20C/4C                   Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:    Reacts with oxidizing materials
     Safety Hazard:  Fiie-very dangerous
                                            AIII-82

-------
                                                                                Isoprene
                               PRODUCTION DATA
Annual U.S.
 Production:

Fraction of
 Dispersion:
              467 x 106 Ibs. (1976 capacity)
              0.01

Release Rate (million Ibs/yr):
Consumption:

Fraction of Pro-
 duction Lost:  0.015
                                  TOXICITY DATA
Acute Toxicity               Dosage
      Concentrations of 5% are fatal to mice
      LCLo                144 mg/m3
                          180mg/m3

Non-lethal Acute Effects:
      Irritant to eyes and mucous membranes
      Anaesthesia at high concentration
                                                Animal

                                               mouse
                                               rat
                     Route

                   inhalation
                   inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                               TLV:
                                       AllI-83

-------
Isopropyl  acetate
                                     CHEMICAL  NAME
    CAS Number:    108-214

    Chemical Name:     Acetic acid, 1-methyl ethyl ester

    Synonyms:   Isopropylacetate
    Molecular
      Formula:
                       O
    Structure:    CH3 - C  - O  - CH
     Chemical Properties

       Molecular Weight:   102.13

       Vapor Pressure:  58.8 mm at 25C

       Boiling Point:    90C at 760 mm

       Density:  0.8718 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:
CH,
                                       CH3
             Physical State:   Liquid

             Vapor Density:   3.52

             Melting Point:   -73.4C

             Solubility:    Soluble (H2O)
     Environmental Persistence

       BOD:    13% of theoretical

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   Fire-dangerous
                   Explosion-moderate
                                            AllI-84

-------
                                                                  Isopropyl acetate
                               PRODUCTION DATA

Annual U.S.
  Production:  41.9 x 106 Ibs., 1967                Consumption:
             (40 x 106 Ibs., 1976 capacity)
Fraction of                                     Fraction of Pro-
  Dispersion:   0.01                               duction Lost: 0.015

Release Rate (million Ibs/yr):    24.8
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
     LC                   3.2%                 rat
     TCLQ               200 ppm              human              inhalation
     LD50              3000mg/kg             rat                 oral

Non-lethal Acute Effects:
     Irritant to eyes, skin, and mucous membranes
     Narcotic
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:    250 ppm

   Other Chronic Effects:   Liver damage
                                      AllI-85

-------
Isopropyl  alcohol
                                      CHEMICAL  NAME
    CAS Number:   67-63-0

    Chemical Name:    Isopropyl alcohol

    Synonyms:   2-Propanol
                sec-Propyl alcohol
                Dimethylcarbinol
    Molecular
      Formula:   C3H8O
                        OH
                        I
    Structure:    CH3 - C - CH3
                        I
                        H
     Chemical Properties

       Molecular Weight:   60.09                        Physical State:  Liquid

       Vapor Pressure:  44.29 mm at 2SC                Vapor Density:  2.07

       Boiling Point:    82.4C at 760 mm                Melting Point:   -89.5C

       Density:  0.7854 at 20C/4C                    Solubility:   Infinite (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:    78% of theoretical after 20 days at 20C
                Total theoretical = 2.4 gm/gm
       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:  Fire-dangerous
                   Explosion-moderate
                                            AllI-86

-------
                                                                  Isopropyl  alcohol
                               PRODUCTION DATA
Annual U.S.
 Production:    1790xl06lbs.

Fraction of
 Dispersion:    0.50

Release Rate (million Ibs/yr): 876.2
                      Consumption:  1698.6 x 106 Ibs.

                      Fraction of Pro-
                       duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
      LD10o
      LD
        so
      LD
        Lo
Non-lethal Acute Effects:
     Conjunctivitis
    | Anemia
     Irritant
  Dosage
5000 mg/kg
6000 mg/kg
 933 mg/kg
6000 mg/kg
  16 mg/kg
2371 mg/kg
 192 mg/kg
1963 mg/kg
   6 mg/kg
                          400 ppm
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 400 ppm


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rabbit
mouse -
mouse
dog
rabbit
human
mouse
cat
mammal
  Route
oral
subcutaneous
intraperitoneal
oral
skin
oral
oral
intravenous .
subcutaneous
                      human
                   inhalation
                      TLV: 400 ppm
                                       AI11-87

-------
Isopropylamine
                                     CHEMICAL NAME
    CAS Number:    75-31-0

    Chemical Name:    Isopropylamine

    Synonyms:   2-Aminopropane
    Molecular
      Formula:   C3H9N
                       NH2
                        I
    Structure:    C% - C  - CH3
                        I
                       H
    Chemical Properties

       Molecular Weight:   59.11                      Physical State:  Liquid

       Vapor Pressure: 321.2 mmat 25C               Vapor Density:  2.03

       Boiling Point:   32.4C at 760 mm               Melting Point:  -95.2C

       Density:  0.694 at 15C/4C                    Solubility:    Infinite (H2O)

       Octanol/Water Parti-
         tion Coefficient:   -0.13

    Environmental Persistence

       BOD: 34% of theoretical after 10 days at 20C

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   Fire-dangerous
                                           AIII-88

-------
                                                                     Isopropylamine
                               PRODUCTION DATA

Annual U.S.
 Production:   18 x 106 ibs.                      Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:    0.01                               duction Lost:  0.015

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
      LDSO                820mg/kg            rat                 oral
                          550mg/kg            rabbit              skin
      LCLo                800 ppm (8 hours)      Tat                 inhalation
                         7000 ppm (40 months)   mouse              inhalation

Non-lethal Acute Effects:
      Strong irritant causing sensitivity of skin and mucous membranes
      Narcotic in high concentrations
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 5 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:  5 ppm

   Other Chronic Effects:
                                       AIII-89

-------
Isopropyl chloride
                                     CHEMICAL NAME
    CAS Number:  75-29-6

    Chemical Name:    2-Chloiopropane

    Synonyms:     Isopropyl chloride
                  Isoprid

    Molecular
      Formula:     C3H7C1



                       Cl
    Structure:     CH3 - CH - CH3
    Chemical Properties

       Molecular Weight:  78.55                       Physical State:     Liquid

       Vapor Pressure:    534.5 mm at 25C             Vapor Density:    2.71

       Boiling Point:   35.74Cat 760mm               Melting Point:     -117.6C

       Density:    0.8617 at 20C/4C                 Solubility:  Slightly soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
             Fire-highly dangerous
             Explosionmoderate
             Disaster hazarddangeroustoxic fumeschlorides and phosgene
                                             AllI-90

-------
                                                              Isopropyl chloride
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                                            Consumption:

                                            Fraction of Pro-
                                             duction Lost:
Acute Toxicity
Non-lethal Acute Effects:
        Anaesthetic
                                TOXICITY DATA

                          Dosage              Animal
                                                                Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                            TLV:
                                     AIII-91

-------
Isopropyl  ether
                                     CHEMICAL  NAME
    CAS Number:   108-20-3

    Chemical Name:    Isopropyl ether

    Synonyms:   2-Isopropoxypropane
                Diisopropyl ether

    Molecular
      Formula:   C6H14O
    Structure:
                     CH,
CH,
     Chemical Properties

       Molecular Weight:   102.17

       Vapor Pressure:  150 mm at 25C

       Boiling Point:    68.5C

       Density:  0.719at25C

       Octanol/Water Parti-
         tion Coefficient:
                       Physical State:   Liquid

                       Vapor Density:   3.52

                       Melting Point:   -88C

                       Solubility:   Soluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-highly dangerous
                   Explosion-severe
                   Disaster hazard-dangeroustoxic fumes-peroxides
                                           AIII-92

-------
                                                                     Isopropyl ether
                              PRODUCTION DATA
Annual U.S.
 Production:    14 x 105 Ibs.

Fraction of
 Dispersion:    1-0

Release Rate (million Ibs/yr):  14.2
                    Consumption:   14 x 106 Ibs.

                    Fraction of Pro-
                      duction Lost:  0.015
Acute Toxicity
      LDSO
 Non-lethal Acute Effects:
      Irritant
      TDLo
       TOXICITY DATA

 Dosage               Animal
812mg/kg            mouse
800 ppm (5 minutes)    human
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 500 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:    Narcotic at high concentrations
  Route
intiaperitoneal
inhalation
                                      AIII-93

-------
o-lsopropylphenol
                                     CHEMICAL NAME
    CAS Number:    88-69-7

    Chemical Name:     o-Isopiopylphenol

    Synonyms:   l-Hydroxy-2-isopropyl benzene
                o-Cumenol

    Molecular
      Formula:   C9H12O
    Structure:
                        CH
                        OH
                               CH,
CH,
    Chemical Properties

       Molecular Weight:   136.20

       Vapor Pressure:     1 mm at 56.6C

       Boiling Point:    213 to214Cat760mm

       Density:  0.995 at 25C/25C

       Octanol/Water Parti-
         tion Coefficient:   1-08
                     Physical State:     Liquid

                     Vapor Density:

                     Melting Point:   15 to 16C

                     Solubility:   Slightly soluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:
          Firemoderate
          Disaster hazard-dangerous-toxic fumes-phenol
                                            AIII-94

-------
                                                               o-lsopropylphenol
                              PRODUCTION DATA

Annual U.S.
 Production:    2084 x 106 ibs. (1976 capacity)      Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:  0.015

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage :             Animal               Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                      AIII-95

-------
p-lsopropylphenol
                                     CHEMICAL NAME
    CAS Number:    99-89-8

    Chemical Name:    p-Isopropyl phenol

    Synonyms:   p-Cumenol
                1 -Hy droxy-4-isopropylphenol

    Molecular
      Formula:   C9H12O
    Structure:
    Chemical Properties

       Molecular Weight:  136.2                      Physical State:     Liquid

       Vapor Pressure:  lmmat67C                  Vapor Density:

       Boiling Point:    228C at 745 mm               Melting Point:  63.2C

       Density:  0.983                               Solubility:   Slightly soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
          Disaster hazard-dangeious-toxic fumes-phenol
                                            AIII-96

-------
                                                              p-lsopropylphenol
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AIII-97

-------
Ketene
     CAS Number:    463-51-4

     Chemical Name:     Ketene

     Synonyms:   Ethenone
                 Carbomethane
                 Keten
     Molecular
      Formula:    C2H2O
                                      CHEMICAL  NAME
Structure:
                     = C = O
     Chemical Properties

        Molecular Weight:   42.04

        Vapor Pressure:

        Boiling Point:   -S6C

        Density:

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
                                                Physical State:   Gas

                                                Vapor Density:  1.45

                                                Melting Point:   -151C

                                                Solubility:   Decomposes (HjO)
     Safety Hazard:
                                             AllI-98

-------
                                                                                 Ketene

                               PRODUCTION DATA
Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITYDATA

Acute Toxicity               Dosage               Animal              Route
       LD50               1300mg/kg            rat                unreported
       LCj_,0                 23 ppm (30 minutes)   mouse             inhalation
                            53 ppm (100 minutes)  rat                inhalation
                            53 ppm (4 hours)      guinea pig           inhalation
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 0.5 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
       Pulmonary edema
                                       AIII-99

-------
Ligninsulfonic  acid, ammonium  salt
                                    CHEMICAL NAME
    CAS Number:  Not listed in 9th Chemical Index

    Chemical Name:     (Complex mixture)

    Synonyms:    Ligninsulfonic acid, ammonium salt
    Molecular
      Formula:    (Complex mixture)
    Structure:  (Several structures are proposed)
    Chemical Properties

       Molecular Weight:    1,000 to 20,000            Physical State:   Solid

       Vapor Pressure:   Negligible at 25C             Vapor Density:

       Boiling Point:  Decomposes above 200C          Melting Point:

       Density:    ca. 1.5                            Solubility:     Infinite (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                          AIII-100

-------
                                     Ligninsulfonic  acid, ammonium salt
                            PRODUCTION DATA

Annual U.S.
 Production:  40xl06lbs.                     Consumption:    40xl06lbs.

Fraction of                                  Fraction of Pro-
 Dispersion:   -98                             duction Lost:   0.03

Release Rate (million Ibs/yr):   40.4
                              TOXICITY DATA

Acute Toxicity             Dosage              Animal             Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                   AIII-101

-------
Ligninsulfonic acid, calcium salt
                                     CHEMICAL  NAME
    CAS Number:      (Not listed in 9th Chemical Index)

    Chemical Name:    (Complex mixture)

    Synonyms:     Ligninsulfonic acid, calcium salt
    Molecular
      Formula:  (Complex mixture)
    Structure:   (Several structures are proposed)
    Chemical Properties

       Molecular Weight:    (Unknown)

       Vapor Pressure:   Negligible

       Boiling Point:   Decomposes

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:

Vapor Density:

Melting Point:

Solubility:   Infinite (H2O)
                                           All I-102

-------
                                           Ligninsulfonic acid, calcium salt
                             PRODUCTION DATA

Annual U.S.
 Production:   326.6 x 106 Ibs.                   Consumption:   326.6 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:    0.98                             duction Lost:  0.03

Release Rate (million Ibs/yr):  329.9
                               TOXICITY DATA

Acute Toxicity              Dosage       ;       Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                     AIII-103

-------
Ligninsulfonic acid,  ferrochrome salt
                                     CHEMICAL  NAME
     CAS Number:   (Not listed in 9th Chemical Index)

     Chemical Name:    (Complex mixture)

     Synonyms:  Ligninsulfonic acid, ferrochrome salt
    Molecular
      Formula:   (Complex mixture)
    Structure:   (Several structures are proposed)
     Chemical Properties

       Molecular Weight: (Unknown)

       Vapor Pressure:    Negligible

       Boiling Point:   Decomposes

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:
Physical State:

Vapor Density:

Melting Point:

Solubility:   Infinite
                                           AllI-104

-------
                                   Ligninsulfonic acid,  ferrochrome salt
                            PRODUCTION DATA

Annual U.S.
 Production:   60xl06lbs.                     Consumption:  60xl06lbs.

Fraction of                                   Fraction of Pro-
 Dispersion:    0.98                            duction Lost:    0.03

Release Rate (million Ibs/yr):    60.6
                              TOXICITY DATA

Acute Toxicity              Dosage             Animal             Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                   AIII-105

-------
Ligninsulfonic acid, sodium  salt
                                     CHEMICAL  NAME
    CAS Number:   Not listed in 9th Chemical Index

    Chemical Name:    (Complex mixture)

    Synonyms:     Ligninsulfonic acid, sodium salt
    Molecular
      Formula:  (Complex mixture)
    Structure:   (Several structures are proposed)
    Chemical Properties

       Molecular Weight:  (Unknown)                   Physical State:

       Vapor Pressure:    Negligible at 25C              Vapor Density:

       Boiling Point:   Decomposes                     Melting Point:

       Density:                                      Solubility:   Infinite

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                           AIII-106

-------
                                           Ligninsulfonic acid,  sodium salt
                             PRODUCTION DATA

Annual U.S.
 Production:   58.7 x 106 Ibs.                    Consumption:   58.7 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:    0.98                             duction Lost:    0.03

Release Rate (million Ibs/yr): 59.3
                               TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:

                                          #


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    All I-10 7

-------
Lindane

                                      CHEMICAL  NAME

    CAS Number:    58-89-9
    Chemical Name:     1,2,3,4,5,6-Hexachloiocyclohexane (gamma isomer)
    Synonyms:    Gamma-benzene hexachloride
                 Gammexane
    Molecular
      Formula:    C6H6C16
    Chemical Properties
       Molecular Weight:    290.82                      Physical State:    Solid
       Vapor Pressure:   0.0317 mm at 20C              Vapor Density:
       Boiling Point:  323.4C at 760 mm                Melting Point:    112.5C
       Density:                                       Solubility:    Insoluble (H2O)
       Octanol/Water Parti-
         tion Coefficient:
    Environmental Persistence
       BOD:
       Atmospheric Reactivity:
     Safety Hazard:
           Disaster hazard-dangerous-phosgene
                                           AIII-108

-------
                             Lindane
PRODUCTION DATA
Annual U.S.
Production: <1.0xl06lbs. Consumption:
Fraction of Fraction of Pro-
Dispersion: Estimated as 1.0 duction Lost:
Release Rate (million Ibs/yr): <1.0
TOXICITY DATA
Acute Toxicity Dosage Animal
LDSO 88 mg/lg rat
500 mg/lg rat
86 mg/lg mouse
60 mg/lg rabbit
50 mg/lg rabbit
1 27 mg/lg guinea pig
180 mg/lg child
840 mg/lg human
35 mg/lg rat
75 mg/lg mouse
50 mg/lg dog
8 mg/lg dog
4000 Mg/kg rabbit
100 mg/kg wild bird
26 mg/kg wild bird
Non-lethal Acute Effects:
Local irritant-dermatitis
CNS stimulation-convulsions
Necrosis of blood vessels in lungs, liver and kidney
Pulmonary edema
Chronic Toxicity
U.S. Occupational Standard: (air) 500 mg/m3(skin)
Carcinogenicity:
Mutagenicity:
TDLo 29 gm/kg (52 weeks) mouse
Teratogenicity: TLV:
Other Chronic Effects:




0.015


Route
oral
skin
oral
oral
skin
oral
oral
oral
intraperitoneal
intraperitoneal
oral
intravenous
intravenous
oral
intramuscular









oral


AIII-109

-------
Linuron
                                      CHEMICAL  NAME






    CAS Number:    330-55-2



    Chemical Name:     3-(3,4-Dichlorophenyl)-l-methoxyl-l-methyl urea



    Synonyms:   Methoxy-l-methyl-3(3,4-dichlorophenyl)urea





    Molecular

      Formula:   C9H10C12N2O2
    Structure:
                  Cl
     O  CH,


     "   '
NH - C - N - OCH,,
                      Cl
     Chemical Properties



       Molecular Weight:    249.11



       Vapor Pressure:



       Boiling Point:



       Density:



       Octanot/Water Parti-

         tion Coefficient:



     Environmental Persistence



       BOD:



       Atmospheric Reactivity:
                      Physical State:   Solid



                      Vapor Density:



                      Melting Point:   93 to 94C



                      Solubility:    Slightly (H2O) (75 ppm at 25C)
     Safety Hazard:
                                           AllI-110

-------
                                                                                 Linuron

                               PRODUCTION DATA
Annual U.S.
 Production:    2.0 x 106 Ibs.                     Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:  Estimated as 1.0                       duction Lost:   0.015

Release Rate (million Ibs/yr):  2.0
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
       LD50               1500 mg/kg             rat                 unreported
                          3300 mg/kg             rat                 oral
                           500 mg/kg             dog                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
        Irritant of nose, eyes, throat and skin
                                      AIII-111

-------
Magenta
                                       CHEMICAL  NAME
     CAS Number:   3248-93-9

     Chemical Name:   4-[(4-Aminophenyl)(4-imino-2,5-cyclohexadien-l-ylidene)methyl] -2-methyl benzenamine
    Synonyms:
    Molecular
      Formula:
    Structure:
Magenta                            Rosaniline
Magenta I                           Fuchsin
a -(p-Aminophenyl)-a (4-imino-2,5-cyclohexadien-ylidene)-2,4-xylidene
2-Methyl4,4'[(4-imino-2,5-cyclohexadien-l-ylidene)methylene]dianiline monohydrochloride
                              H2N
     Chemical Properties

        Molecular Weight:  337.8

        Vapor Pressure:

        Boiling Point:

        Density:

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
                           ^^ NH2(+) Cl(~)
                                   Physical State:

                                   Vapor Density:

                                   Melting Point:
Solid
186C (decomposes)
                                   Solubility:  Slightly (H2O)
     Safety Hazard:
                                            AIII-112

-------
                                                                               Magenta

                               PRODUCTION DATA
Annual U.S.
 Production:   0.116 x 106 Ibs. (1964)              Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:    0.01S

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
        LDLo           150 mg/kg             rabbit              oral
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:   Recognized carcinogen
      Neoplastic effects:
        TDLo           2500 mg/kg (52 weeks)   mouse              oral
   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AIII-113

-------
Malathion


                                     CHEMICAL  NAME

    CAS Number:    121-75-5
    Chemical Name:    Mercapto-succinic acid, diethyl ester, S-estei with O.O-dimethyl phosophorodithioate

    Synonyms:  Malathion
               O,O-Dimethyl-S-l,2-bis (ethoxy carbonyl) ethyl dithiophosphate

    Molecular
      Formula:   C10H19O6PS2
    Structure:            ^ P -  S - CH - C-  OCH2CH3

                  CH3            CH2 - C - OCH2CH3
                                          II
                                          O

    Chemical Properties

       Molecular Weight:   330.96                      Physical State:  Liquid

       Vapor Pressure:  4 x 10"5 mm at 30C            Vapor Density:

       Boiling Point:   \56CatWmm                 Melting Point:  2.85C

       Density:  1.23 at 25C/4C                     Solubility:   Slightly (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental  Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
                                           AllI-114

-------
                                                                             Malathion
                               PRODUCTION DATA
Annual U.S.
 Production:   30xl06lbs. (1972)

Fraction of
 Dispersion:    1.0

Release Rate (million Ibs/yr):  30.3
                     Consumption:  30 x 10  Ibs.

                     Fraction of Pro-
                      duction Lost: 0.01
Acute Toxicity
     LDSO
                                 TOXICITY DATA
599 mg/kg
340 mg/kg
 50 mg/kg
193 mg/kg
500 mg/kg
 Animal
fat
rat
rat
mouse
mammal
  Route
oral
intraperitoneal
intravenous
intraperitoneal
unreported
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 15 mg/m3 (skin)



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV: 15 mg/m3

   Other Chronic Effects:    Allergic sensitization of skin
                                     AIII-115

-------
Maleic acid
                                      CHEMICAL NAME
    CAS Number:   110-16-7

    Chemical Name:    Maleic acid

    Synonyms:  Maleinic acid
                Toxilic acid
                cis-Butenedioic acid
    Molecular
      Formula:  C4H4O4
                    H

Structure:    o = C "
                  /
                  OH
                           C ~
                                           O
                                    OH
    Chemical Properties

       Molecular Weight:   116.07

       Vapor Pressure:    Essentially O

       Boiling Point:   135C-decomposes

       Density:   1.590 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:   -0.79

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
            Stable to ultraviolet irradiation
     Safety Hazard:   Fire-slight
                                                 Physical State:   Solid

                                                 Vapor Density:  4.0

                                                 Melting Point:   139 to 140C

                                                 Solubility:   Very soluble (H2O)
                                            All1-116

-------
                                                                            Maleic acid
                               PRODUCTION DATA

Annual U.S.
 Production:   283.2 x 106 Ibs. (1974)              Consumption:  ca. 283.2 x 106 Ibs.

Fraction of                                      Fraction of Pro-
 Dispersion:                                       duction Lost: 0.015

Release Rate (million Ibs/yr):
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LD50                708 mg/kg            rat                  oral
                         1560 mg/kg            rabbit               skin

Non-lethal Acute Effects:
      Irritant
      Hypofunction of glycogen synthesis in liver
      Conjunctivitis
      Dermatitis
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                      AllI-117

-------
Maleic  anhydride
                                     CHEMICAL  NAME
    CAS Number:    108-31-6

    Chemical Name:    Maleic anhydride

    Synonyms:   Toxilic anhydride
                cis Butene dioicanhydiide

    Molecular
      Formula:   C4H2O3
    Structure:
     Chemical Properties

       Molecular Weight:   98.06                       Physical State:   Solid

       Vapor Pressure:  1 mm at 44C                   Vapor Density:  3.4

       Boiling Point:    197 to 199C                   Melting Point:   60C

       Density:  1.48 at 20C/4C                      Solubility:   Reacts with water; Soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing agents
     Safety Hazard:  Fire: moderate-toxic fumes
                                          AIII-118

-------
                                                                  Maleic anhydride
                              PRODUCTION DATA

Annual U.S.
 Production:  211.8 x 106 Ibs. (1975)                Consumption:  230 x 106 Ibs. (1975)

Fraction of                                     Fraction of Pro-
 Dispersion:    0.01                              duction Lost:  0.015

Release Rate (million Ibs/yr): 4.72
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDso                60 mg/kg            mouse             oral
      LDLo               850 mg/kg            rat                oral

Non-lethal Acute Effects:
      Burns to eyes and skin
      Pulmonary edema
Chronic Toxicity

   U.S. Occupational Standard:  (air): TWA 0.25 ppm



   Carcinogenicity:
      TDLo                610 mg/kg (61 weeks)          rat                subcutaneous

   Mutagenicity:

   Teratogenicity:                                TLV: 0.25 ppm

   Other Chronic Effects:
                                     AIII-119

-------
Maleic  hydrazide
                                     CHEMICAL  NAME
    CAS Number:    123-33-1

    Chemical Name:     l,2-Dihydro-3,6-pyndazinedione

    Synonyms:   Maleic hydrazide
                3,6-Dioxo-l,2,3,6-tetrahydropyridazine

    Molecular
      Formula:   C4H4N2O2
                H

    Structure:
Chemical Properties

   Molecular Weight:   112.09

   Vapor Pressure:

   Boiling Point:

   Density:

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
     Safety Hazard:   Fire: Dangerous-toxic fumes
                                                    Physical State:  Solid

                                                    Vapor Density:

                                                    Melting Point:   >300C decomposes

                                                    Solubility:   Slightiy soluble (H2O)
                                           AIII-120

-------
                                                                  Maleic hydrazide
Annual U.S.
 Production:    3 x 106 Ibs.

Fraction of
 Dispersion:    1.0

Release Rate (million Ibs/yr): 3.0
                              PRODUCTION DATA
                                              Consumption:
                                              Fraction of Pro-
                                               duction Lost:  0.01S
                                 TOXICITY DATA
Acute Toxicity
     LDso

     LDLo
                          Dosage
                         3800 mg/kg
                         8800 mg/kg
 Animal
rat
mouse
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity: (suspected)
      TDLo               1300 mg/kg (65 weeks)   rat
                         8800 mg/kg ( 3 weeks)   mouse
   Mutagenicity:
   Teratogenicity:

   Other Chronic Effects:
                                              TLV:
  Route
oral
subcutaneous
                                                                subcutaneous
                                                                subcutaneous
                                     AIII-121

-------
Malic acid



                                      CHEMICAL  NAME

                   (dl): 617-48-1
    CAS Number:   (d): 636-61-3
                   (1): 97-67-6
    Chemical Name:    DL - Malic acid            .      L - Malic acid
                      D - Malic acid
    Synonyms:     Hydroxysuctinic acid
                   Apple.acid-

    Molecular
      Formula:'     C4H6O5
              HO      O
                 XC/X
                    I
               H-C-H

    Structure::  H-C-OH
                    I

                 'C*
              HO      O

    Chemical Properties

        Molecular Weight:   134.09                       Physical State:     Solid

        Vapor Pressure:	           Vapor Density:
                      150C (dl) (decomposes)
        Boiling Point:   140C (d and 1) (decomposes)       Melting Point:   128C (dl)
                                         -   -                       iooC (d and 1)
        Density:     1.601 at 20C/4C(dl)               Solubility:   Very soluble (H2O)
                   1.595 at 20C/4C(d and 1)
        Octanol/Water Parti-
         tion Coefficient:     -1.53

    Environmental Persistence:

        BOO:

        Atmospheric Reactivity:
     Safety Hazard:
                                           AIII-122

-------
                                                                           Malic acid

                              PRODUCTION DATA
Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     dilution Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage              Animal               Route
        Unspecified optical isomer
          LDLo            1600mg/kg            rat                 oral
        L (+) isomer
          LDLo            5000mg/kg            rat                 oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AIII-123

-------
Mela mine
                                      CHEMICAL  NAME
     CAS Number:   108-78-1

     Chemical Name: Melamine

     Synonyms:  2,4,6-Triamine-S-triazine
                Cyanurotriamide
                2,4,6-Ttiamino-l ,3,5-triazine
     Molecular
      Formula:  C3H6N6
    Structure:
     Chemical Properties

        Molecular Weight:   126.13

        Vapor Pressure:  50 mm at 315C

        Boiling Point:   Sublimes

        Density:   1.573 at 20C/4C

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
     Safety Hazard:   Disaster Hazard: Dangerous-toxic fumes-cyanides
Physical State:   Solid

Vapor Density:  4.34

Melting Point:   354C (decomposes)

Solubility:   Slightly soluble (H2O)
                                            AIII-124

-------
                                                                          Melamine
                             PRODUCTION DATA

Annual U.S.                                                _    	
 Production:   170 x 106 Ibs (1973)               Consumption:  110 x 106 Ibs. (1975)

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost: 0.015

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDLo              1600 mg/kg            mouse             oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AIII-125

-------
Mesitylene
                                     CHEMICAL NAME
    CAS Number:   95-63-6

    Chemical Name: 1,3,4-Trimethyl benzene

    Synonyms:   Mesitylene
    Molecular
      Formula:   C9H12
                         CH,
    Structure:
                 CH,
CH,
     Chemical Properties

       Molecular Weight:  120.21

       Vapor Pressure:

       Boiling Point:    164.7C at 760 mm

       Density:  0.8637 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
                     Physical State:  Liquid

                     Vapor Density:

                     Melting Point:   -44.7C

                     Solubility:   Insoluble (H2O)
                                          AIII-126

-------
                                                                             Mesitylene
Annual U.S.
 Production:

Fraction of        \
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
Acute Toxicity
        TOXICITY DATA

  Dosage               Animal
2400 ppm (24 hours)     rat
1500 mg/kg             rat
1303 mg/kg             guinea pig
Non-lethal Acute Effects:
      Narcotic leucopenia and thrombocytopenia
      Dermatitis and conjunctivitis
      Central nervous system:
                           10 ppm
                      human
  Route
inhalation
intraperitoneal
intraperitoneal
                                         inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 25 ppm


   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
                                       AIII-127

-------
Mesityl  oxide
                                     CHEMICAL  NAME
    CAS Number:   141-79-7

    Chemical Name:    4-Methyl-3-penten-2 one

    Synonyms:   Mesityl oxide
    Molecular
      Formula:   C6Hi0O
    Structure:
                 CH,
                  CHi
            O
            I!
C  =  CH - C - CHo
     Chemical Properties

       Molecular Weight:  98.14

       Vapor Pressure:  9.16 mm at 25C

       Boiling Point:    130C at 760 mm

       Density:  0.8653 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:  1.24
                           Physical State:  liquid

                           Vapor Density:  3.38

                           Melting Point: -52.85C

                           Solubility:    Soluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing material
    Safety Hazard:   Fire-Moderate
                                          AIII-128

-------
                                                                         Mesityl oxide
                               PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Itas/yr):
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
     LD50               1120mg/kg             rat                 oral
                          354 mg/kg             mouse              intraperitoneal
                         1000 mg/kg             rabbit              oral
     LCLo               1000 ppm (4 hours)      rat                 inhalation
     LDj_,0               1000 mg/kg             rat                 intiapeiitoneal

Non-lethal Acute Effects:
     Local irritant
     Causes opaque cornea
     Keratoconus
     Extensive necrosis of the cornea
     Liver and kidney effects
     Damage to lungs
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 25 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:  25 ppm

   Other Chronic Effects:
                                      AIII-129

-------
Methacrylic acid
                                     CHEMICAL  NAME
    CAS Number:   79-41-4

    Chemical Name:    Methacrylic acid

    Synonyms:  o-Methyl acrylic acid
               2-Methyl propenoic acid

    Molecular
      Formula:  C4H6O2
    Structure:    CH-, =
CH3
I
C - C - OH
     II
     o
     Chemical Properties

       Molecular Weight:  86.1

       Vapor Pressure:  1 mm at 25.5C

       Boiling Point:    162 to 163C at 757 mm

       Density:  1.0153 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:   Fire-moderate
                   Disaster Hazard: dangerous-toxic fumes
                           Physical State:  Liquid

                           Vapor Density:

                           Melting Point:  16C

                           Solubility:   Soluble (H2O)
                                          AIII-130

-------
                                                                  Methacrylic acid
                              PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     auction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDSO                49mg/kg            mouse              intraperitoneal

Non-lethal Acute Effects:
     Local irritant to eyes and trachea
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AIII-131

-------
Methacrylonitrile
                                     CHEMICAL  NAME
    CAS Number:   126-98-7

    Chemical Name:    Methacrylonitrile

    Synonyms:  2-Methylpropenitiile
               Isoptopene cyanide

    Molecular
      Formula:  C4HSN
                        CH3
                        I
    Structure:    H2C =  C - C  = N
     Chemical Properties

       Molecular Weight:  67.09

       Vapor Pressure: 72.38 mm at 25C

       Boiling Point:   90.3C at 760 mm

       Density:  0.7998 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:
Physical State:  Liquid

Vapor Density:

Melting Point:   -35.8C

Solubility:   Insoluble (H2O)
                                          AIII-132

-------
                                                                    Methacrylonitrile
                               PRODUCTION DATA
Annual U.S.
 Production:

Fraction of
 Dispersion:
10 x ICTlbs. (1967 capacity)
Consumption:

Fraction of Pro-
 duction Lost:  0.015
Release Rate (million Ibs/yr):
                                  TOXICITY DATA
Acute Toxicity
      LDSO

      LDLo

      LC50
 Non-lethal Acute Effects:
      Dermatitis
      Lachrymation
             Dosage
            250 mg/kg
            320 mg/kg
             15 mg/kg
             65 mg/kg
            328 ppm (4 hours)
             36 ppm (4 hours)
             37 ppm (4 hours)
             80 ppm (4 hours)
 Animal
rat
rabbit
mouse
mouse
rat
mouse
rabbit
guinea pig
  Route
oral
skin
oral
intraperitoneal
inhalation
inhalation
       i
inhalation
inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 1 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:    Highly toxic following skin absorption or inhalation
                                      AIII-133

-------
Methallyl alcohol
                                     CHEMICAL NAME
    CAS Number:    513-42-8

    Chemical Name:    2-Methyl-2-piopen-l-ol

    Synonyms:   Methallyl alcohol
                Methallyl hydroxide

    Molecular
      Formula:   C4H8O
    Structure:     HO - CH2 - C  = CH2
                              CH,
     Chemical Properties

       Molecular Weight:  72.12

       Vapor Pressure:

       Boiling Point:    114.49C

       Density:  0.8540 at 20C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
Physical State:  Liquid

Vapor Density:

Melting Point:

Solubility:   Infinite (H2O)
                                          AIII-134

-------
                                                                Methallyl alcohol
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDL0               500 mg/kg            mouse             oral
                        2000mg/kg            rabbit              skin
      LCLo              2924 ppm (2 hours)      mouse             inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                    AIII-135

-------
Methallyl  chloride
                                     CHEMICAL NAME
    CAS Number:   563-47-3

    Chemical Name:    3-Chloro-2-methyl propene
    Synonyms:
    Molecular
      Formula:
2-Butene-l -chloride
1 -Chloro-2-butene(cis)
(3-Methallyl chloride

C4H7C1
    Structure:          C = C
               	/       \
                               CH2a
     Chemical Properties

       Molecular Weight:  90.55

       Vapor Pressu re:  101.7 mm at 20 C

       Boiling Point:    84.1C at 758 mm

       Density:    0.9426 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:
                                                   Liquid

                                                   3.12
Physical State:

Vapor Density:

Melting Point:

Solubility:  Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
             Fiie-dangerous
             Explosion-moderate
             Disaster hazard-dangerous-toxic fumes-chlorides
                                           AIII-136

-------
                                                                Methallyl chloride
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
                                TOXICITY DATA
Acute Toxicity
        LCSO
  Dosage
Animal
2000 mg/m (24 hours)   rat
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
  Route
inhalation
                                     AIII-137

-------
Methane
    CAS Number:   74-82-8

    Chemical Name:   Methane

    Synonyms:  Marsh gas
               Methyl hydride

    Molecular
      Formula:  CH4
                                     CHEMICAL NAME
               H

Structure:    H - C~H~

              "if



Chemical Properties

   Molecular Weight:  16.04

   Vapor Pressure:

   Boiling Point:  -164C at 760mm

   Density:  0.415at-165C

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
       Residence in atmosphere: 4 to 7 years
                                                   Physical State: Gas

                                                   Vapor Density: 0.6

                                                   Melting Point:  -182.48C

                                                   Solubility:  Soluble (H2O)
     Safety Hazard:
                                          AIII-138

-------
                                                                             Methane

                              PRODUCTION DATA
Annual U.S.
 Production:    12,400 x 106 Ibs (1964)            Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:   0.0IS

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route

      LCso              400 ppm              rat                inhalation
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AIII-139

-------
Methanearsonic acid
                                    CHEMICAL NAME
    CAS Number:  124-58-3

    Chemical Name:   Methanearsonic acid

    Synonyms:  Methyl arsonic acid


    Molecular
      Formula:  CH5AsO3
                     O
                     II
    Structure:  CH3 - As - OH

                     OH
    Chemical Properties

       Molecular Weight:  139.97

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:  Solid

Vapor Density:

Melting Point:  160tol61C

Solubility:  Soluble (H2O)
                                         AIII-140

-------
                                                          Methanearsonic  acid
                             PRODUCTION DATA

Annual U.S.
 Production:   30.7 x 106 Ibs.                    Consumption:   30.7 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:   1.0                              duction Lost:  0.01

Release Rate (million Ibs/yr): 31
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDSo              3350mg/kg           mouse              subcutaneous
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AIII-141

-------
Methomyl
                                     CHEMICAL  NAME


    CAS Number:   16752-77-5

    Chemical Name:    N-([(Methylamino)caibonyl] oxy)ethanimidothioic acid, methyl estei

    Synonyms:     S-Methyl-N-[(methylcarbamoyl)-oxy] -thioacetimidate
    Molecular
      Formula:     csHioN22s
                 CH,-S                  O
                         N   	... ..'/
    Structure:               c = N - O - C
                         /              \
                     H3C                  N - CH3

                                          TT

    Chemical Properties

       Molecular Weight:  162.23                       Physical State:     Solid

       Vapor Pressure:                                Vapor Density:

       Boiling Point:                                  Melting Point:     78to79C

       Density:                                      Solubility:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                           AIII-142

-------
                                                                             Methomyl
Annual U.S.
 Production:

Fraction of
 Dispersion:
              2.0 x 10 Ibs.
              Estimated as 1.0

Release Rate (million Ibs/yr):  2.0
                               PRODUCTION DATA
Consumption:

Fraction of Pro-
 duction Lost:
                 0.015
Acute Toxicity
         LDso
                                 TOXICITY DATA
                           Dosage
                         17 mg/kg
                         24 mg/kg
                         15 mg/kg
                         10 mg/kg
 Animal
rat (male)
rat (female)
duck
wild bird species
  Route
oral
oral
oral
oral
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                              TLV:
                                      AIII-143

-------
Methoxychlor
                                     CHEMICAL  NAME


    CAS Number:   72-43-5

    Chemical Name:    l,l,l-Trichloro-2,2-bis(p-methoxyphenyl) ethane

    Synonyms:  DMDT
               2,2-bis(p-Methoxyphehyl)-l>l>l-trichloroe thane
               Methoxychlor
    Molecular
      Formula:  C,6H1SC13O2



                 	H 	
                          /=V   '    f,^
    Structure:      CH3O -(\   ff~c   \ '   /   OCH3

                             a  -c -  a
                                  i
                                  a

    Chemical Properties

       Molecular Weight:  345.7                       Physical State:  Solid

       Vapor Pressure:                                Vapor Density:  12

       Boiling Point:                                  Melting Point:  94C

       Density:                                      Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
           Slight air contaminant




    Safety Hazard:  Disaster hazard: Dangerous-toxic fumes-chlorides
                                          AIII-144

-------
                                                                       Methoxychlor
                               PRODUCTION DATA

Annual U.S.
 Production::   10.0 x 106 Ibs.                     Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:    1.0                               duction Lost:  0.015

Release Rate (million Ibs/yr):  10.0
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LDSO               5000mg/kg            rat                 oral
                         6430 mg/kg            human .             oral
                         24 14 mg/kg            human skin          unspecified toxic effects
 Non-lethal Acute Effects:
      Nausea and vomiting
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 15 mg/m3
   Carcinogenicity:
        Neoplastic effects
           1100 mg/kg (36 weeks)                  rat                oral
   Mutagenicity:

   Teratogenicity:                               TLV:  15 mg/m3

   Other Chronic Effects:    Kidney injury
                                     AIII-145

-------
Methoxyethanol
                                     CHEMICAL NAME
    CAS Number:    109-86-4

    Chemical Name:    2-Methoxy ethanol

    Synonyms:   Methyl glycol
                Methoxy hydioxy ethane
                Methyl cellosolve
    Molecular
      Formula:   C3H8O2
    Structure:   CH3 - O - CH2 - CH2 - OH
    Chemical Properties

       Molecular Weight:   76.09

       Vapor Pressure: 6.2 mm at 20C

       Boiling Point:   124.6C

       Density:  0.9660 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:   -0.82

    Environmental Persistence

       BOD:     88% of theoretical after 20 days at 20C
                Total theoretical oxygen demand = 1.68 gm/gm
       Atmospheric Reactivity:
                             Reacts with oxidizing materials
    Safety Hazard:   Fire-Moderate
Physical State:  Liquid

Vapor Density:  2.62

Melting Point:  -85.1C

Solubility:    Infinite (H2O)
                                          AIII-146

-------
                                                                    Methoxyethanol
                               PRODUCTION DATA
Annual U.S.
 Production:  119.1 x 106 ibs.

Fraction of
 Dispersion:   0.26

Release Rate (million Ibs/yr): 29.4
                      Consumption:  106.1 x 106 Ibs.

                      Fraction of Pro-
                       duction Lost: 0.015
                                 TOXICITY DATA
Acute Toxicity
     LDso
  Dosage
2460 mg/kg
2140mg/kg
 890 mg/kg
1340 mg/kg
 950 mg/kg
3570 mg/kg
 Animal
rat
rat
rabbit
rabbit
guinea pig
human
Non-lethal Acute Effects:
     Aplastic anemia
                        2000 ppm (4 hours)
                          25 ppm
                     rat
                      human (CNS)
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
  Route
oral
intravenous.
oral
skin
oral
oral
                                        inhalation
                   inhalation
                                     AIII-147

-------
Methyl acetate
                                     CHEMICAL  NAME
    CAS Number:   79-20-9

    Chemical Name:    Acetic acid, methyl ester

    Synonyms:  Methyl acetate


    Molecular
      Formula:  C3H6O2
                        O
                -~"     II
    Structure:     CH3 - C  - O - CH3
    Chemical Properties

       Molecular Weight:  74.08                       Physical State:   Liquid

       Vapor Pressure:  212.5 mm at 25C                Vapor Density:  2.55

       Boiling Point:    57.8C                         Melting Point:   -98.1C

       Density:  0.9330 at 20C/4C                    Solubility:   Very soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire: dangerous
    .   .            Explosion: moderate
                                          AIII-148

-------
                                                                      Methyl acetate
                               PRODUCTION DATA

Annual U.S.
 Production:  8.8 x 10  ibs. (1966)                 Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                      duction Lost:  0.015

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
      LDSO               3700 mg/kg            rabbit              oral
      LDLo               4800 mg/kg            rat                 oral
                         3000 mg/kg            rat                 subcutaneous
                         3000 mg/kg            guinea pig           subcutaneous
                           80mg/m (31 minutes) mouse              inhalation
                           67 mg/m (56 minutes) cat                 inhalation
 Non-lethal Acute Effects:
      Narcotic
      Irritant to eyes and mucous membranes (10,000 ppm)
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 200 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:  200 ppm

   Other Chronic Effects:
                                     AIII-149

-------
Methyl  acetoacetate
                                    CHEMICAL  NAME
    CAS Number:    105-45-3

    Chemical Name:    Acetoacetic acid, methyl ester

    Synonyms:  Methyl acetylacetonate
    Molecular
     Formula:  CSH8O3
                               O
    Structure:   CH3 - C - CH2 - C - O CH3
    Chemical Properties

       Molecular Weight:   116.05

       Vapor Pressure:  0.7 mm at 20C

       Boiling Point:   171.7C

       Density:  1.0785 at 20C/20C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:   Liquid

Vapor Density:

Melting Point:   -31.9C

Solubility:   Slightly (H2O)
                                         AIII-150

-------
                                                          Methyl acetoacetate
                             PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDSO             3000 mg/kg           rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                   AIII-151

-------
Methylal


                                     CHEMICAL NAME


    CAS Number:   109-87-5

    Chemical Name:    Dimethoxy me thane

    Synonyms:   Formal                               Methylal
                Methylene dimethyl ether               Formaldehyde dimethyl acetal

    Molecular
      Formula:   C3H8O2
                           H
                 	I	
    Structure:     H3C - O - C - O -
    Chemical Properties

       Molecular Weight:  76.1                        Physical State:  Liquid

       Vapor Pressure:  330 mm at 20C                 Vapor Density: 2.63

       Boiling Point:    45.5C at 760mm               Melting Point:  -104.8C

       Density:  0.8593 at 20C/4C                    Solubility:   Soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Fire-dangerous
                   Explosion-moderate
                                           AIII-152

-------
                                                                               Methylal


                               PRODUCTION DATA
Annual U.S.
 Production:                                    Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                      duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
      LDL0               3013mg/kg            guinea pig            subcutaneous

Non-lethal Acute Effects:
      Injury to lungs, kidney, liver and heart
      Narcotic in high concentration
Chronic Toxicity

   U.S. Occupational Standard:   (air) TWA 1000 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV: 1000 ppm

   Other Chronic Effects:
                                     AI11-153

-------
Methyl alcohol
                                     CHEMICAL  NAME
    CAS Number:   67-56-1

    Chemical Name:    Methanol

    Synonyms:  Methyl alcohol
               Carbinol
               Methyl hydroxide
    Molecular
      Formula:  CH4O
    Structure:    CHjOH
    Chemical Properties

       Molecular Weight:  32.04

       Vapor Pressure:    127.9 mm at 25C

       Boiling Point:   64.8C

       Density:    0.7913at20C/4C

       Octanol/Water Parti-
         tion Coefficient:                              ,

    Environmental Persistence

       BOD:    95% of theoretical at 20C for 20 days
                Total theoretical oxygen demand = 1.5 gm/gm
       Atmospheric Reactivity:
          Reacts with oxidizing materials
    Safety Hazard:  Fire-dangerous
                  Explosion-moderate
Physical State:  Liquid

Vapor Density:  1-11

Melting Point:  -93.9C

Solubility:   Infinite (H2O)
                                          AIII-154

-------
                                                                        Methyl  alcohol
                               PRODUCTION DATA
Annual U.S.
 Production:

Fraction of
 Dispersion:
5103.5 x 1 (Tibs. (1975)
0.01
Consumption:

Fraction of Pro-
 duction Lost:  0.015
Release Rate (million Ibs/yr): 987.7
                                  TOXICITY DATA
Acute Toxicity
      LD50
      LC
         SO
           9800 mg/kg
            340 mg/kg
           1800 mg/kg
            420 mg/kg
           6300 mg/kg
           7000 mg/kg
           4750 mg/kg
           1000 ppm
 Non-lethal Acute Effects:
      Eye-irritant, blindness
         TDLo
      CNS narcotic
         TD
           Lo
            .100 mg/kg

            300 ppm
 Animal
mouse
human
rat
mouse
dog
donkey
rabbit
monkey
human

human
  Route
subcutaneous
oral
intraperitoneal
oral
oral
oral
oral
inhalation
oral

inhalation
      Irritant to mucous membranes; drying of skin; dermatitis


Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 200 ppm



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
        Conjunctivitis
        Headache
        Giddyness
        Insomnia
        Gastric disturbances
        Failure of vision-300 ppm
                                 TLV:  200ppm
                                 Odor perception: 5,900 ppm
                                      AIII-155

-------
Methylamine
                                     CHEMICAL NAME
    CAS Number:   74-89-5

    Chemical Name:    Methylamine

    Synonyms:  Monomethylamine
               Aminomethane

    Molecular
      Formula:  CH5N
                H
    Structure:
                        H
                       CH,
    Chemical Properties

       Molecular Weight:  31.1

       Vapor Pressure:  2509 mm at 25C

       Boiling Point:    -6.3C at 760 mm

       Density:  0.662 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:  -1.00
Physical State:  Gas

Vapor Density:  1.07

Melting Point:   -93.5C

Solubility:   Very soluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   Fiie-dangerous
                   Explosion-moderate
                                          AIII-156

-------
                                                                        Methylamine
                              PRODUCTION DATA

Annual U.S.
 Production:   319 x 106 Ibs (1976 capacity)        Consumption: 185 x 106 Ibs. (1975-all methyl amines)
Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                     Fraction of Pro-
                       duction Lost: 0.015
Acute Toxicity
     LD50

Non-lethal Acute Effects:
     Strong irritant
        TOXICITY DATA


3000 mg/kg
 Animal
mouse
  Route
intiaperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
                                     AIII-157

-------
Methylamyl  acetate
                                     CHEMICAL NAME
    CAS Number:   108-84-9

    Chemical Name:   4-Methyl-2-pentanol, acetate

    Synonyms:     4-Methyl-2-pentyl acetate
                  Acetic acid, 1,3-dimethylbutyl ester
                  Methylisobutylcarbinol acetate
    Molecular
      Formula:  C8H16O2
                               CH3        CH3
    Structure:     CH3 - C - O - CH - CH2 - CH - CH3
    Chemical Properties

       Molecular Weight:  144.21                      Physical State:  Liquid

       Vapor Pressure:    3. mm at 20C                Vapor Density:  4.97

       Boiling Point:   147 to 148C                   Melting Point:  -63.8C

       Density: 0.8805 at 0C/0C                    Solubility:  Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-moderate
                                          AIII-158

-------
                                                            Methylamyl acetate
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                                            Consumption:

                                            Fraction of Pro-
                                             duction Lost:
Acute Toxicity
Non-lethal Acute Effects:
  Eye irritation:
                                TOXICITY DATA

                          Dosage              Animal
                       4000 ppm             rat
                       100 ppm              human
                                                                Route
                                                              inhalation
                                                              inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 50 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                            TLV:
                                   AIII-159

-------
Methylamyl alcohol
                                    CHEMICAL  NAME
    CAS Number:   108-11-2

    Chemical Name:   4-Methyl-2-pentanol

    Synonyms:  Methyl isobutyl carbinol
               Methyl amyl alcohol

    Molecular
      Formula:  C6H14O
                      CH.,
OH
    Structure:    CH3 - CH - CH2 - C - CH3
                                  I
                                ~H
    Chemical Properties

       Molecular Weight:  102.18

       Vapor Pressure:  2.8 ram at 20C

       Boiling Point:   133C at 760 ram

       Density: 0.8075 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:
                  Physical State:  Liquid

                  Vapor Density: 3.53

                  Melting Point:  -90C (sets)

                  Solubility:   Slightly (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Fire-moderate
                                         AIII-160

-------
                                                               Methylamyl alcohol
                              PRODUCTION DATA
Annual U.S.
 Production:   50 x 106 Ibs.

Fraction of
 Dispersion:    0.80

Release Rate (million Ibs/yr): 40.8
                     Consumption:   50 x 10  Ibs.

                     Fraction of Pro-
                      duction Lost:  0.015
                                 TOXICITY DATA
Acute Toxicity
      LDso
  Dosage
 812mg/kg
3560 mg/kg
2600 mg/kg
2000 ppm (4 hours)
Animal
mouse
rabbit
rat
rat
  Route
intraperitoneal
skin
oral
inhalation
Non-lethal Acute Effects:
      Local irritant
      Anesthetic in high concentrations
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 25 ppm (skin)


   Carcinogenicity:
   Mutagenicity:

   Teratoganicity:

   Other Chronic Effects:
                     TLV:
                                     AIII-161

-------
Methylaniline
                                     CHEMICAL  NAME
    CAS Number:   100-61-8

    Chemical Name:    N-Methyl aniline

    Synonyms:  Monomethyl aniline
               Methyl phenylamine

    Molecular
      Formula:  C7H9N

             ~H       CHL
                 \    /
    Structure:
    Chemical Properties

       Molecular Weight:  107.15                      Physical State:   Liquid

       Vapor Pressure:  1 mm at 36C                   Vapor Density:  3-70

       Boiling Point:    196.25C at 760 mm             Melting Point:   -57C

       Density: 0.98912 at 20C/4C                   Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:  1.82

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Disaster hazard-dangerous-toxic fumes-aniline
                                          AIII-162

-------
                                                                         Methylaniline
                               PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                     . auction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
     LD50                 24 mg/kg            cat                 intravenous
                          280 rag/kg            rabbit               oral
                           24 mg/kg            rabbit               intravenous
                         1200 mg/kg            guinea pig           oral
                         1200 mg/kg            guinea pig           subcutaneous

Non-lethal Acute Effects:
     Allergen
     Hemorrhage in bladder
     Nervous disorders
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 2 ppm
   Carcinogenicity: Carcinogen
      Neoplastic Effects:
        TDLo               380 mg/kg (28 weeks)    mouse               oral
   Mutagenicity:

   Teratogenicity:                                TLV: 2 ppm (skin)

   Other Chronic Effects:
                                      AIII-163

-------
Methylbenzyl alcohol
                                     CHEMICAL  NAME


    CAS Number:   98-85-1

    Chemical Name:    o-Methylbenzyl alcohol

    Synonyms:  Methyl phenyl caibinol                  Styialyl alcohol
               Phenyl methyl caibinol                  1-Phenyl ethanol

    Molecular
      Formula:  C8H10O
                          OH
                   	    I

    Structure:     /   V "cf-CH~


                          H
    Chemical Properties

       Molecular Weight:  122.16                       Physical State:  Liquid

       Vapor Pressure:    0.25 mm at 25C              Vapor Density: 4.21

       Boiling Point:   203C at 760 mm                 Melting Point:  20.7C

       Density:  1.0129 at 20C/4C                    Solubility:   Slightly soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:   Fire-moderate
                                           AIII-164

-------
                                                          Methy(benzyl alcohol
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDSO              400mg/kg            rat                oral
                       2500 mg/kg            rabbit              skin
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                   AIII-165

-------
Methyl bromide
                                    CHEMICAL NAME
    CAS Number:   74-83-9

    Chemical Name:    Bromomethane

    Synonyms:  Methyl bromide
    Molecular
     Formula:   CH3Br
    Structure:
    H
    ]__
H-C-Br
   J_
    H
    Chemical Properties

       Molecular Weight:  94.95

       Vapor Pressure:  1370mmat25C

       Boiling Point:   3.56C at 760 mm

       Density:  1.6755 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-moderate
                  Explosionmoderate
                  Disaster hazard-dangerous-toxic fumes-bromides
                                   Physical State:  Volatile liquid or gas

                                   Vapor Density:  3.72

                                   Melting Point:  -93.6C

                                   Solubility:   Slightly (13.4 gm/1) (H2O)
                                          AIII-166

-------
                                                                      Methyl bromide
                               PRODUCTION DATA
Annual U.S.           "
 Production:   24.6 x 106 ibs. (1972)

Fraction of
 Dispersion:    0.90

Release Rate (million Ibs/yr): 22.4
                      Consumption:   24.6 x 106 Ibs.

                      Fraction of Pro-
                       duction Lost:  0.01
                                  TOXICITY DATA
Acute Toxicity
     LC50
  21 mg/1
 514 ppm (6 hours)
6425 ppm (1 hour)
 300 ppm (9 hours)
Non-lethal Acute Effects:
   Irritate of eyes, skin, and mucous membranes
   Damage to liver and kidney
   CNSeffects
 Animal
rat
rat
rabbit
guinea pig
       TCLo

   Skin effects
       TCLo
  35 ppm
8000 ppm
                                               human
human
Chronic Toxicity

   U.S. Occupational Standard:  (air) Ceiling 20 ppm (skin)


   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:  20 ppm
     Nausea, vomiting, headache after   35 ppm for two weeks
     Severe lung iritation
  Route
inhalation
inhalation
inhalation
inhalation
                   inhalation
                   skin
                                     AIII-167

-------
Methyl  butyl ketone
                                    CHEMICAL  NAME
    CAS Number:  591-78-6

    Chemical Name:    Methyl n-butyl ketone

    Synonyms:   2-Hexanone
               n-Butyl methyl ketone

    Molecular
     Formula:   C6H12O
                     O
    Structure:   CH3 - C - CH2CH2CH2CH3
    Chemical Properties

       Molecular Weight:  100.16

       Vapor Pressure: 10 mm at 38.8C

       Boiling Point:   128C at 760 mm

       Density:  0.81127 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:  1.38
Physical State:  Liquid

Vapor Density: 3.45

Melting Point:  -57C

Solubility:   Slightly (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
    Safety Hazard:  Fire-moderate
                  Explosion-moderate
                                         AIII-168

-------
                                                               Methyl butyl ketone
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                 TOXICITY DATA
Acute Toxicity
     LD50
  Dosage
2590 mg/kg
 914 mg/kg
 914 mg/kg
6000 ppm (7 hours)
 Animal
rat
rat
guinea pig
guinea pig
  Route
oral
intraperitoneal
oral
inhalation
Non-lethal Acute Effects:
      Irritant to eyes and respiratory tract
      CNS depressant
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
                                     AIII-169

-------
Methylbutynol
                                     CHEMICAL NAME
    CAS Number:   115-19-5

    Chemical Name:    2-Methyl-3-butyn-2-ol

    Synonyms:  Methyl butynol
               l,l-Dimethyl-2-propynol
               Ethynyldimethylcaibinol
    Molecular
      Formula:  C5H8O
    Structure:
  OH
  I
- C - C==CH
  |
  CH~,
    Chemical Properties

       Molecular Weight:  84.13

       Vapor Pressure:

       Boiling Point:   104C at 760mm

       Density: 0.8618 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-moderate
                               Physical State:  Liquid

                               Vapor Density:

                               Melting Point:  3.0C

                               Solubility:  Soluble (H2O)
                                          AIII-170

-------
                                                                    Methylbutynol
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
Acute Toxicity

     LD50
        TOXICITY DATA

  Dosage              Animal

3600 mg/kg            mouse
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
  Route

intraperitoneal
                                    AI11-171

-------
Methyl cellulose
                                     CHEMICAL  NAME
    CAS Number:  9004-67-5

    Chemical Name:   Methyl ether cellulose
    Synonyms:
    Molecular
      Formula:
Methyl cellulose
Cellulose methyl ether
Methocel
    Structure:
     Chemical Properties

       Molecular Weight: 40,000-180,000

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
                                                        _J   n
                                  Physical State:    Solid

                                  Vapor Density:

                                  Melting Point:

                                  Solubility:  Soluble (H2O)
                                           AIII-172

-------
                                                                 Methyl  cellulose
                              PRODUCTION DATA

Annual U.S.
 Production:   20 x 106 Ibs.                      Consumption:     13 x 106 Ibs.

Fraction of                                    Fraction of Pro-
 Dispersion:   1-0                               duction Lost:    0.03

Release Rate (million Ibs/yr): 13.6
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                    AIII-173

-------
Methyl chloride
                                     CHEMICAL NAME
    CAS Number:   74-87-3

    Chemical Name:    Chloromethane

    Synonyms:   Methyl chloride
    Molecular
      Formula:   CH3G1
    Structure:
    H
    I
H - cf- a
    i
    H
     Chemical Properties

       Molecular Weight:  50.49

       Vapor Pressure:  2.83 atm at 25C

       Boiling Point:    -24.2C at 760'mm

       Density:  0.9159 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
          Reacts with oxidizing materials
          Reacts slowly with RC^ and O,
          tl with OH = 1 year
     Safety Hazard:  Fire-dangerous
                   Explosionmoderate
                   Disaster hazarddangeroustoxic fumes-chlorides
                                   Physical State:  Gas

                                   Vapor Density:  1.78

                                   Melting Point:  -97.73C

                                   Solubility:   Soluble (4.9 gm/1 H2O)
                                           AIII-174

-------
                                                                      Methyl chloride
                               PRODUCTION DATA
Annual U.S.
 Production:   458 x 106 Ibs. (1974)

Fraction of
 Dispersion:    0.03

Release Rats (million Ibs/yr): 18.1
                        Consumption:   312 x 10 Ibs. (1975)

                        Fraction of Pro-
                         duction Lost: 0.01
                                  TOXIGITY DATA
Acute Toxicity
      LDSO
  1800mg/kg
  3000 ppm (4 hours)
  3146 ppm (7 hours)
20,000 ppm (2 hours)
 Animal
rat
rat
mouse.
guinea pig
  Route
oral
inhalation
inhalation
inhalation
Non-lethal Acute Effects:
      Slight irritant
      Narcotic
      CNS damage
      Damage to bone, liver, kidney, and cardiovascular system
      Pulmonary edema
      Conjunctivitis
      Anemia       '.
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppm
                            Ceiling 200 ppm
                            Peak 300 ppm/5 min/3 hours

   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                        TLV:  100 ppm
                                      AIII-175

-------
Methylcholanthrene
                                    CHEMICAL  NAME
    CAS Number:  56-49-5

    Chemical Name:   3-Methyl cholanthrene
    Synonyms:
    Molecular
      Formula:
20-Methylcholanthrene
1,2-Dihydro-3-methy lbenz(j) aceanthrylene
    Structure:
    Chemical Properties

       Molecular Weight:  268.3

       Vapor Pressure:

       Boiling Point:  280C at 80 mm

       Density:    1.28 at 20C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                 Physical State:

                                 Vapor Density:

                                 Melting Point:

                                 Solubility:
Solid
                                         AIII-176

-------
                Methylcholanthrene
PRODUCTION DATA
Annual U.S.
Production:
Fraction of
Dispersion:
Release Rate (million Ibs/yr)

Acute Toxicity
LDLo

Chronic Toxicity





TOXICITY
Dosage
100 mg/kg
11 mg/kg


Consumption:
Fraction of Pro-
duction Lost:

DATA
Animal
mouse
frog







Route
intraperitoneal
intrarenal

U.S. Occupational Standard:
Carcinogenicity:
TDLo













Neoplasm TOLO





Mutagenicity:
Teratogenicity:
Other Chronic Effects:

280 mg/kg
18 mg/kg
3 mg/kg
100 mg/kg (5 weeks)
800 Mg/kg
13 mg/kg (4 2 weeks)
31 2 Mg/kg
120 mg/kg
132 mg/kg (12 weeks)
4 mg/kg
40 mg/kg (15 days)
58 mg/kg
4500 mg/kg (8 weeks)
27 mg/kg
34mg/kg (25 weeks)
39 mg/kg (6 days)
1600 mg/kg (20 weeks)
40 mg/kg
100 mg/kg (9 weeks)
3320 mg/kg (40 weeks)




rat
rat
rat
rat
rat
mouse
mouse
mouse
rabbit
guinea pig
guinea pig
hamster
chicken
duck
rat
rat
mouse
dog
rabbit
hamster

TLV:


oral
subcutaneous
parenteral
intratracheal
implant
skin
subcutaneous
intratracheal
intratracheal
intraperitoneal
subcutaneous
implant
intraperitoneal
intratracheal
skin
intravenous
intraperitoneal
implant
implant
skin



AIII-177

-------
Methylcyclohexane
                                    CHEMICAL  NAME
    CAS Number:   108-87-2

    Chemical Name:    Methylcyclohexane

    Synonyms:  Hexahydrotoluene
               Cyclohexylmethane

    Molecular
     Formula:  C7H14
    Structure:
                        CH-,
    Chemical Properties

       Molecular Weight:  98.19

       Vapor Pressure:  47.06 mm at 25C

       Boiling Point:   100.9C at 760 mm

       Density:  0.7694 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:  Fire-dangerous
                  Explosionmoderate
Physical State:  Liquid

Vapor Density:  3.39

Melting Point:   -126.59C

Solubility:   Insoluble (H2O)
                                         AIII-178

-------
                                                              Methylcyclohexane
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
      LDLo              4000 rag/kg            rabbit              oral
      LCSo              7500 ppm (70 minutes)   rabbit              inhalation

Non-lethal  Acute Effects:
   Irritates skin      	
   Narcosis and anesthesia
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA SOO ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:  500 ppm

   Other Chronic Effects:
                                    AIII-179

-------
Methylcyclohexanol
                                     CHEMICAL NAME
    CAS Number:   25639-42-3

    Chemical Name:   Methylcyclohexanol
    Synonyms:
    Molecular
      Formula:
4-Methyl cyclohexanol
Hexahy drome thy 1 phenol
Hexahydio cresol

C7H14O
    Structure:
     Chemical Properties

       Molecular Weight: 114.19

       Vapor Pressure:   
-------
                                                             Methylcyclohexanol
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
        LDLo            1750 mg/kg           rabbit              oral

 Non-lethal Acute Effects:
        Irritant to eyes and trachea
        Leucopenia
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:   100 ppm

   Other Chronic Effects:
                                    AIII-181

-------
Methyl cyclohexanone
                                   CHEMICAL  NAME
    CAS Number:  583-60-8

    Chemical Name:   2-Methyl cyclohexanone

    Synonyms:
    Molecular
     Formula:     C7HnO
                 O
    Structure:
                      CH,
    Chemical Properties

       Molecular Weight: 112.17

       Vapor Pressure:   <5 mm at 25C

       Boiling Point:  165C at 757 mm

       Density:    0.9250 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
           Fire-moderate
Physical State:    Liquid

Vapor Density:   3.86

Melting Point:    -13.9C

Solubility:  Insoluble (H2O)
                                        AIII-182

-------
                                                          Methylcyclohexanone
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute toxicity              Dosage              Animal              Route
        LD50           2140mg/kg            rat                 oral
        LDLo           lOOOmg/kg            rabbit              oral

 Non-lethal Acute Effects:

        Local irritant
        Damage to liver and kidney
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:   100 ppm

   Other Chronic Effects:
                                    AIII-183

-------
4,4-Methylenebis(2-chloroaniline)
                                    CHEMICAL  NAME


    CAS Number:   101-14-4

    Chemical Name:   4,4'-Methylenebis[2-chloro benzenamine]

    Synonyms:
    Molecular
      Formula:
4,4'-Methylene-bis(2 chloroaniline)
Bisamine
Diamino-3-chlorophenyl-me thane
Cyanaset
Dacpm
Curalin
    Structure:
     Chemical Properties

       Molecular Weight:  267.16

       Vap or Pressu re:   Negligible

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:
                                  Physical State:    Solid

                                  Vapor Density:

                                  Melting Point:    104tol07C

                                  Solubility:
                                         All1-184

-------
                                        4,4-Methylenebis(2-chloroaniline)
                             PRODUCTION DATA

Annual U.S.
 Production:  7.716 x 106 Ibs. (1972)             Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:   0.01                              duction Lost:    0.015

Release Rate (million Ibs/yr): 0.1
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
       TDLo           420 gm/kg (80 weeks)   rat                oral
                       2SOO mg/kg (88 weeks)   rat                subcutaneous
   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                   AIII-185

-------
Methylene chloride
                                     CHEMICAL  NAME
    CAS Number:  75-09-2

    Chemical Name:   Dichloromethane

    Synonyms:  Methylene chloride
               Methylene dichloiide

    Molecular
      Formula:  CH2C12
                     Cl
                     J
    Structure:     H - C - Cl
                     I
                     H
    Chemical Properties

       Molecular Weight: 84.93                        Physical State: Liquid

       Vapor Pressure:   435.8 ram at 25C              Vapor Density: 2.93

       Boiling Point:   40C at 760 mm                  Melting Point: -95.1C

       Density: 1.3266 at 20C/4C                    Solubility:  Slightly (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:   Total theoretical oxygen demand-0.38 gm/gm

       Atmospheric Reactivity:
               Not very active towards 03 and
               tvi = 1 year with OH
    Safety Hazard:  Explosion-minor
                  Disaster hazard-dangerous-toxic fumes-phosgene
                                           AIII-186

-------
                                                                  Methylene chloride
                                PRODUCTION DATA
 Annual U.S.
  Production:   591 x 106 Ibs. (1974)

 Fraction of
  Dispersion:   -95

 Release Rate (million Ibs/yr):   366.8
                    Consumption: Estimated as 110 to 120 x 10  Ibs.
                                (1975)
                    Fraction of Pro-
                      duction Lost:    0.015
                                  TOXICITY DATA
 Acute Toxicity
     LD50


     LD10o
Dosage
2136mg/kg
1500 mg/kg
6460 mg/kg
 950 mg/kg
1900 mg/kg
3000 mg/kg
2700 mg/kg
 200 mg/kg
2700 mg/kg
5000 ppm (2 hours)
  Animal
rat  ',
mouse
mouse
dog
rabbit
dog
dog
dog
rabbit
guinea pig
Route
oral
intraperitoneal
subcutaneous
intraperitoneal
oral
oral
subcutaneous
intravenous
subcutaneous
inhalation
Non-lethal Acute Effects:
   Central nervous system effects: narcosis
     TCLo                  500 ppm (1 year) intermittent
   Blood effects:
     TCLo                  500 ppm (8 hours)
 Chronic Toxicity

    U.S. Occupational Standard:  (air)  TWA
                                 Ceiling
                                 Peak

    Carcinogenicjty:
    Mutagenicity:

    Teratogenicity:

    Other Chronic Effects:
           Dermatitis
           Liver damage
           Reduced growth size
               500 ppm
              1000 ppm
              2000 ppm/5 minutes/2 hours
                    TLV:   500ppm
                                      AIII-187

-------
Methylenedianiline
                                     CHEMICAL NAME
    CAS Number:   101-77-9
    Chemical Name:    4,4'-Methylenedianiline
    Synonyms:    Methylenedianiline
    Molecular
      Formula:  C13Hi4N2
    Structure:
                                            NH
Chemical Properties

   Molecular Weight:   198.3

   Vapor Pressure: <10 mm at 25C

   Boiling Point:

   Density:             .   .

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
    Safety Hazard:   Disaster hazard-dangerous-toxic fumes-aniline
                                                   Physical State:  Solid

                                                   Vapor Density:

                                                   Melting Point:  90C

                                                   Solubility:
                                          AIII-188

-------
                                                               Methylenedianiline
Annual U.S.
 Production:   2.205 x 106 Ibs.

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                     Consumption:
                     Fraction of Pro-
                       duction Lost: -015
Acute Toxicity
     LDso
        TOXICITY DATA

  Dosage              Animal
347 mg/kg             rat
280 mg/kg             rat
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
      Carcinogen:
        TDLo
      Neoplasm:
        TDLo
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
  80 mg/kg

1410 mg/kg
                     Route
                  oral
                  subcutaneous
rat

rat



TLV:
oral

subcutaneous
                                    AIII-189

-------
Methyldioxolane
                                     CHEMICAL  NAME
    CAS Number:   1331-09-5

    Chemical Name:   Methyl dioxolane

    Synonyms:     2-Methyl-3-dioxolane
    Molecular
      Formula:    C4H8O2
    Structure:
    Chemical Properties

       Molecular Weight: 88.12                       Physical State:    Liquid

       Vapor Pressure:                               Vapor Density:    3.03

       Boiling Point:  81 to82Cat 760mm             Melting Point:

       Density:    0.9811 at 20C/4C                 Solubility:  Very soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
                                          AIII-190

-------
                                                                 M ethyl dioxolane
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
       LDSO            3000mg/kg            rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AI11-191

-------
Methyl ethyl  ketone
                                     CHEMICAL  NAME
    CAS Number:    78-93-3

    Chemical Name:    2-Butanone

    Synonyms:   Methyl ethyl ketone
                Methyl acetone

    Molecular
      Formula:   C4H8O
                      O
                      II
    Structure:    CH3 - C - CH2 - CH3
    Chemical Properties

       Molecular Weight:  72.12                       Physical State:   Liquid

       Vapor Pressure:  96.4 mm at 25C                 Vapor Density:  2.41

       Boiling Point:    79.6C at 760 mm                Melting Point:   -86.35C

       Density:  0.8054 at 20C/4C                    Solubility:   Very soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:  0.29

    Environmental Persistence                            '

       BOD:    89% of theoretical after 20 days at 20C      -
                Total theoretical oxygen demand 2.44 gm/gm
       Atmospheric Reactivity:
          Reacts with oxidizing materials
     Safety Hazard:   Fire-dangerous
                   Explosion-moderate
                                           AIII-192

-------
                                                              Methyl  ethyl ketone
                               PRODUCTION DATA
Annual U.S.
 Production:  509 x 106 Ibs.

Fraction of
 Dispersion:   0.95

Release Rate (million Ibs/yr): 524.7
Consumption:  544.3 x 106 Ibs.

Fraction of Pro-
  duction Lost: 0.015
Acute Toxicity
     LD50
                                 TOXICITY DATA
 Animal
rat
mouse
rat
rat
3400 mg/kg
 616 mg/kg
2000 mg/kg
2000 ppm (4 hours)
Non-lethal Acute Effects:
     Local irritation and narcosis
     Numbness of fingers and arms: 300 to 600 ppm
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 200 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
      Local irritation and narcosis
  Route
oral
intraperitoneal
intraperitoneal
inhalation
TLV: 200 ppm
   Odor perception: 25 ppm
                                     AIII-193

-------
Methyl formate
                                     CHEMICAL  NAME
    CAS Number:   107-31-3

    Chemical Name:    Formic acid, methyl ester

    Synonyms:  Methyl methanoate
               Methyl formate

    Molecular
     Formula:  C2H4O2
                    O
    Structure:    H - C - O - CH,
    Chemical Properties

       Molecular Weight:   60.05

       Vapor Pressure:    602.5 mm at 25C

       Boiling Point:   32.0C

       Density: 0.975 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:
Physical State:  Liquid

Vapor Density:  2.07

Melting Point:  -99C

Solubility:  Very soluble (H2O)
    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:  Fire-dangerous
                  Explosion -moderate
                  Disaster hazard-dangerous-toxic fumes
                                           AIII-194

-------
                                                                    Methyl  formate
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                       Consumption:

                       Fraction of Pro-
                        duction Lost:
                                 TOXICITY DATA
Acute Toxicity
     LDSO
    Dosage
 1620 mg/kg
10,000 ppm
 Animal
rabbit
guinea pig
  Route
oral
inhalation
Non-lethal Acute Effects:
     Irritation of conjunctivia and optic nerve
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                       TLV:  100ppm
                                     AIII-195

-------
Methylhydrazine
                                    CHEMICAL  NAME
    CAS Number:   60-34-4

    Chemical Name:    Methylhydrazine

    Synonyms:  Monomethylhydiazine
    Molecular
      Formula:  CH6N
    Structure:
N  - N
                 H3C
    Chemical Properties

       Molecular Weight:   46.07

       Vapor Pressure: 49.6 mm at 25C

       Boiling Point:   87C at 745 mm

       Density:  0.874 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:
                             Physical State:  Liquid

                             Vapor Density:  1.6

                             Melting Point:  <-80C

                             Solubility:   Soluble (H2O)
                                         AIII-196

-------
                                                                     Methyl hydrazine
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                  TOXICITY DATA
Acute Toxicity
      LCSO
  Dosage
183mg/kg
 21 mg/kg
 17 mg/kg
 33 mg/kg
 33 mg/kg ,
 96 mg/kg
 12 mg/kg
 49 mg/kg
 22 mg/kg
239 mg/kg
 21 mg/kg
 74 ppm (4 hours)
 56 ppm (4 hours)
 96 ppm (1 houi)
 82 ppm (1 hour)
143 ppm (4 hours)
Animal
rat
rat
rat
rat
mouse
rabbit
rabbit
guinea pig
hamster
hamster
hamster
rat
mouse
dog
monkey
hamster
Chronic Toxicity
   U.S. Occupational Standard:  (air) 0.2 ppm
   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:
                            Ceiling 350 /ig/m  (skin)
3000 mg/kg (47 weeks)   hamster
      TD
        Lo
   Other Chronic Effects:
                      TLV:
100 mg/kg (8-12 days)    mouse
200 mg/kg (14 days)     rabbit
  Route
skin
intraperitoneal
intravenous
oral
oral
skin
intravenous
skin
oral
skin
intraperitoneal
inhalation
inhalation
inhalation
inhalation
skin
                    oral
                   oral
                   oral
                                      AIII-197

-------
Methyl iodide
                                     CHEMICAL  NAME
    CAS Number:    74-88-4

    Chemical Name:    lodomethane

    Synonyms:   Methyliodide
    Molecular
      Formula:   CH3I
    Structure:
    H
    I
H-C-I
    l_
    H
    Chemical Properties

       Molecular Weight:   141.94

       Vapor Pressure:  400 mm at 25.3C

       Boiling Point:    42.4C at 760 mm

       Density:  2.279  at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:   1.80

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
          Residence in atmosphere: 0.003 year
    Safety Hazard:   Disaster hazard-dangerous-toxic fumes-iodides
                                    Physical State:   Liquid

                                    Vapor Density:  4.89

                                    Melting Point:   -66.45C

                                    Solubility:   Slightly (H2O)
                                          AIII-198

-------
                                                                        Methyl iodide
Annual U.S.
 Production:

Fraction of
 Dispersion:'

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
                                 TOXICITY DATA
Acute Toxicity
      LDSO
                     Animal
                     rat
                     mouse
                     rat
426 mg/m3 (24 hours)   mouse
220 mg/kg
HOmg/kg
800 mg/kg
Non-lethal Acute Effects:
      Strong narcotic and anaesthetic
      Irritant
      Nausea and vomiting
Chronic Toxicity

   U.S. Occupational Standard:   (aii) TWA 5 ppm (skin)
   Carcinogenicity:
      Neoplasm TDi_,0

   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 50 mg/kg
                     rat
                     TLV:
  Route
oral
subcutaneous
skin
inhalation
                                        subcutaneous
                                     AIII-199

-------
Methyl  isoamyl  ketone
                                    CHEMICAL  NAME
    CAS Number:   110-12-3

    Chemical Name:    S-Methyl-2-hexanone

    Synonyms:  Methyl iso-amyl ketone
               MIAR

    Molecular
      Formula:  C7Hi4O
                     O              CH,
                     II              I  J
    Structure:   CH3 - C - CH2 - CH2 - CH
                                    I
                                    CH,
    Chemical Properties

       Molecular Weight:   114.19

       Vapor Pressure:

       Boiling Point:   144C at 760 mm

       Density:  0.888 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:   Liquid

Vapor Density:

Melting Point:

Solubility:   Slightly (H2O)
                                         AIII-200

-------
                                                        Methyl isoamyl ketone
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                    Consumption:

                    Fraction of Pro-
                      duction Lost:
                               TOXICITY DATA
Acute Toxicity
      LDso
      LDLo
      LCLo
  Dosage
4760 mg/kg
3200 mg/kg
2000 ppm (4 hours)
Animal
rat
mouse
rat
  Route
oral
oral
inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppm


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                    TLV:
                                   AIII-201

-------
Methyl  isobutyl  ketone
                                     CHEMICAL NAME
    CAS Number:   108-10-1

    Chemical Name:    4-Methyl-2-pentanone

    Synonyms:  Methyl isobutyl ketone
               Isobutyl methyl ketone
               Hexone
    Molecular
      Formula:  C6H12O
                             Isopropylacetone
                             MIBK
    Structure:
CH - CH2 - C
                CH0
                                      O
               CH,
    Chemical Properties

       Molecular Weight:  100.16

       Vapor Pressure: 7.1 mm at 25C

       Boiling Point:   116.85C at 760mm

       Density: 0.7978 at 20C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence
       BOD:    69% of theoretical after 20 days at 20C
                Total theoretical oxygen demand = 2.7 gm/gm
       Atmospheric Reactivity:
          Reacts vigorously with reducing materials
    Safety Hazard:  Fire-moderate
                             Physical State:  Liquid

                             Vapor Density:  3.45

                             Melting Point:   -84.7C

                             Solubility:   Slightly (H2O)
                                          AIII-202

-------
                                                         Methyl isobutyl  ketone
                              PRODUCTION DATA
Annual U.S.
 Production:    208.3 x 106 Ibs.

Fraction of
 Dispersion:    0.95

Release Rate (million Ibs/yr): 201.0
                     Consumption:   208.3 x 106 Ibs.

                     Fraction of Pro-
                       duction Lost:  0.0 IS
Acute Toxicity
     LDSO
      LCLo
Non-lethal Acute Effects:
     Irritation effects
        TCLo
        TOXICITY DATA

  Dosage              Animal
 268 mg/kg            mouse
2080 mg/kg            rat  
2850 mg/kg            mouse
4000 ppm (15 minutes)   rat
 200 ppm
human
                     Route
                   intraperitoneal
                   oral
                   oral
                   inhalation
                                        inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppm



   Carcinogenicity:


   Mutagehicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV: 100 ppm
                     Odor perception: 8 ppm
                                     AIII-203

-------
Methyl  isocyanate
                                     CHEMICAL NAME
    CAS Number:  624-83-9

    Chemical Name:   Isocyanic acid, methyl estei
    Synonyms:
    Molecular
      Formula:
Methyl isocyanate
Methyl carbylamine

C2H3NO
    Structure:   CH3 - N = C = O
    Chemical Properties

       Molecular Weight:  57.05

       Vapor Pressure:

       Boiling Point:  59.6C

       Density:    0.9230 at 27C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
                                  Physical State:   Liquid

                                  Vapor Density:

                                  Melting Point:    -45 C

                                  Solubility:  Soluble (H2O)
                                            Reacts with H2O
                                           AI11-204

-------
                                                                 Methyl  isocyanate
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
                                 TOXlCITY DATA
Acute Toxicity
        LCSO
 Non-lethal Acute Effects:
        Pulmonary edema
          TCLo
   Dosage
14 ppm (4 hours)
10 ppm (4 hours)
 8 ppm (4 hours)
13 ppm (4 hours)
 0.5 ppm
 Animal
rat
mouse
rabbit
guinea pig
                                              human
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 0.02 ppm (skin)



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                      TLV:
   Route
inhalation
inhalation
inhalation
inhalation
                   inhalation
                                     AIII-205

-------
Methyl mercaptan
                                     CHEMICAL  NAME
    CAS Number:   74-93-1

    Chemical Name:    Methanethiol

    Synonyms:  Methyl mercaptan
    Molecular
      Formula:   CH4S
    Structure:
    H
    I
H-C-S-H
    I
    H
     Chemical Properties

       Molecular Weight:  48.11

       Vapor Pressure:  760 mm at 6.8C

       Boiling Point:    6.2C

       Density:  0.8665 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:
                                    Physical State:   Liquid 01 gas

                                    Vapor Density:  1.66

                                    Melting Point:   -123C

                                    Solubility:   Slightly (H20)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   Fire-dangerous
                   Disaster hazard-dangerous-toxic fumes-SOx
                                          AIII-206

-------
                                                               Methyl mercaptan
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
     LDSO              2.4 mg/kg              mouse              subcutaneous
     LCLo          10,000 ppm               rat                inhalation
Non-lethal Acute Effects:
      Irritant
Chronic Toxicity

   U.S. Occupational Standard:   (air) Ceiling 10 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV: 0.5 ppm

   Other Chronic Effects:
                                    AIII-207

-------
Methyl  methacrylate
                                    CHEMICAL  NAME
    CAS Number:   80-62-6

    Chemical Name:    Methacrylic acid, methyl ester

    Synonyms:  Methyl methaciylate
               2-Methyl propenoic add, methyl ester

    Molecular
     Formula:  C5H8O2
                     CHUO
                    _l   II
    Structure:   CH2 = C - C - OCH3
    Chemical Properties

       Molecular Weight:   100.13                      Physical State:   Liquid

       Vapor Pressure:  40 mm at 25.5C                Vapor Density:  3.45

       Boiling Point:   100 to 101Cat 760mm          Melting Point:   -48C

       Density:   0.9440 at 20C/4C                   Solubility:   Slightly (H2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
    Safety Hazard:   Fire-moderate
                   Explosionmoderate
                                          AIII-208

-------
                                                              Methyl methacrylate
                               PRODUCTION DATA
Annual U.S.    	    	
 Production:   718.8 x 106 Ibs. (1974)

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                                               Consumption:   625 x 106 Ibs.

                                               Fraction of Pro-
                                                duction Lost: 0.015
                                 TOXICITY DATA
Acute Toxicity
     LD50
     LC50

Non-lethal Acute Effects:
    Irritant effect
                           Dosage
                        7500 mg/kg
                        1000 mg/kg
                        6300 mg/kg
                        4500 mg/kg
                        6300 mg/kg
                        2000 mg/kg
                        6300 mg/kg
                        1800 mg/kg
                        5000 mg/kg
                        6550 mg/kg
                        3750 ppm
 Animal
rat
mouse
mouse
dog
guinea pig
guinea pig
guinea pig
rat
dog
rabbit
rat
     TC
        .
        Lo
                        '. 125 ppm
    Central nervous system effects
       TC
         Lo
                         150 mg/mj
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppm


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
human

human
   Route
subcutaneous
intraperitoneal
subcutaneous
subcutaneous
oral
intraperitoneal
subcutaneous
intraperitoneal
oral
oral
inhalation
inhalation

inhalation
                                               TLV:    100 ppm
                                      AIII-209

-------
Methylnaphthalene
                                    CHEMICAL  NAME
    CAS Number:  1321-944

    Chemical Name:   Methylnaphthalene

    Synonyms:    1-Methyl naphthalene
    Molecular
      Formula:
                        CH,
    Structure:
     Chemical Properties

       Molecular Weight:  142.21

       Vapor Pressure:    <10 mm at 25C

       Boiling Point:  244.64C at 760 mm

       Density:   1.0202 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:
Physical State:    Liquid

Vapor Density:

Melting Point:    -22C

Solubility:  Insoluble (H2O)
                                         AIII-210

-------
                                                            Methyl naphthalene
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal             Route
       LDSO              5000mg/kg         rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                   AIII-211

-------
N-Methyl-N-nitro-N-nitrosoguanidine
                                    CHEMICAL  NAME
    CAS Number:   70-25-7

    Chemical Name:    l-MethyI-3-nitro-l-nitrosoguanidine

    Synonyms:  N-Methyl-N'-nitio-nitrosoguanidihe

               N'-Nitro-N-nitroso-N-methylguanidine

    Molecular
      Formula:  C2HSNSO3
             O
                 N      NH     H
                   \    II     /
    Structure:        N - C - N
               	/          \	
               H,C             NO,
    Chemical Properties

       Molecular Weight:   147.1

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:

Vapor Density:

Melting Point:

Solubility:
                                         AIII-212

-------
                                      N-Methyl-N-nitro-N-nitrosoguanidine
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                    Consumption:

                    Fraction of Pro-
                     duction Lost:
                                TOXICITY DATA
Acute Toxicity
      LDLo
 Dosage  _
400 mg/kg
Animal
rat
  Route
oral
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
                          75 mg/kg (4 weeks)
                          40 mg/kg (4 weeks)
                          40 mg/kg (10 weeks)
                         200 mg/kg (32 days)
                         100 mg/kg
                         200 mg/kg (22 weeks)
                          48 mg/kg
                        2457 mg/kg (66 weeks)
                         740 mg/kg (2.7 weeks)
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                    rat
                    rat
                    rat
                    rat
                    mouse
                    mouse
                    mouse
                    dog
                    hamster
                    TLV:
                   oral
                   intiaperitoneal
                   subcutaneous
                   rectal
                   oral
                   skin
                   subcutaneous
                   oral
                   oral
                                    AIII-213

-------
Methyl parathion
                                      CHEMICAL NAME



    CAS Number:   298-00-0

    Chemical Name:   O,O-Dimethyl phosphorothioic acid O-{p-nitrophenyl) ester


    Synonyms:  Methyl parathion
                O,O-Dimethyl-O-p-nitrophenyl phosphorothioate

    Molecular
      Formula:  C8Hi0NO5PS
                   OCH,
                   I    J
    Structure:   S = P - O
                   I
                   OCH,
     Chemical Properties


       Molecular Weight:  263.20


       Vapor Pressure:  0.97 mm at 20C


       Boiling Point:    Decomposes
        Density:  1.358 at 20C/4C
        Octanol/Water Parti-
         tion Coefficient:  1.44

     Environmental Persistence

        BOO:

        Atmospheric Reactivity:
     Safety Hazard:
         Explosion-commercial product decomposes at 120 C with violence
Physical State:  Solid


Vapor Density:


Melting Point:  35-36C


Solubility:   Slightly soluble (55 to 60 ppm H2O)
                                           AIII-214

-------
                                                                  Methyl parathion
                               PRODUCTION DATA
Annual U.S.
 Production:  51.1 x 106 Ibs.

Fraction of
 Dispersion:   Estimated as 1.0

Release Rate (million Ibs/yr):   52.7
 Consumption: 52.2 x 10  Ibs.

 Fraction of Pro-
  duction Lost:   -01
                                 TOXICITY DATA
Acute Toxicity
                             9 mg/kg
                            67 mg/kg
                          3500 mg/kg
                            23 mg/kg
                          9300 mg/kg
                            30 mg/kg
                           300 mg/kg
                             7 mg/kg
                            25 mg/kg
  Animal
rat
rat
rat
mouse
mouse
mouse
rabbit
wild bird
mammal
 Route
oral
skin
intraperitoneal
intraperitoneal
intraperitoneal
subcutaneous
skin
oral
unreported
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 200 ng/m3


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 TLV:
                                     AIII-215

-------
M ethyl pentanediol
                                     CHEMICAL  NAME
    CAS Number:   10741-5

    Chemical Name:    2-Methyl-2,4-pentanediol

    Synonyms:   2,4-Dihydroxy-2-methylpentane
                a A^'-Trimethyltrimethylene glycol

    Molecular
      Formula:   C6H14O2
                      H        CH3
                      I          I
    Structure:    CH, - C - CH, - C - CH,
                   J   ,      L   ,      3
                      OH      OH
    Chemical Properties

       Molecular Weight:  118.06

       Vapor Pressure:  <0.1 mm at 20C

       Boiling Point:    198C

       Density:

       Octanol/Water Parti-
         tion Coefficient:  -0.14

    Environmental Persistence

       BOD:    90% of theoretical after 20 days at 20C
                Total theoretical oxygen demand-2.3 (gm/gm)
       Atmospheric Reactivity:
    Safety Hazard:
Physical State:  Liquid

Vapor Density:

Melting Point:  -50C

Solubility:   Infinite (H2O)
                                          AIII-216

-------
                                                              Methyl pentanediol
                              PRODUCTION DATA
Annual U.S.
 Production:   SO x 106 Ibs.

Fraction of
 Dispersion:   1.0

Release Rate (million Ibs/yr): 50.1
                     Consumption:   50 x 106 Ibs.

                     Fraction of Pro-
                      duction Lost:  0.015
                                TOXICITY DATA
Acute Toxicity
     LDso
  Dosage
3696 mg/kg
3860 mg/kg
1299 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
rat
mouse
mouse
  Route
oral
oral
intiaperitoneal
                     TLV:
                                   AIII-217

-------
Methylpentynol
                                     CHEMICAL  NAME
    CAS Number:   n-15-8

    Chemical Name:    3-Methyl-l-pentyn-3-ol

    Synonyms:  Methyl pentynol
               2-Ethynyl-2-butanol
               Dormison
    Molecular
      Formula:  C6H10O
                            CH3
    Structure:    HjC - CH~2 - C - C =
                              __
                             off
    Chemical Properties.

       Molecular Weight:  98-15                        Physical State:  Liquid

       Vapor Pressure:                                Vapor Density:  3.38

       Boiling Point:    120 to 121C                    Melting Point:   30 to 31C

       Density:  0.8688 at 20C/4C                    Solubility:   Soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:  1.80

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reactive toward oxidizing materials
    Safety Hazard:   Fire-slight
                                           AIII-218

-------
                                                                     M ethyl pentynol
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                    Consumption:

                    Fraction of Pro-
                      duction Lost:
                                 TOXICITY DATA
Acute Toxicity
      LD50
300 mg/kg
698 mg/kg
750 mg/kg
5 34 mg/kg
 Non-lethal Acute Effects:
   Psychotropic effects:
      TDLo                 7 mg/kg
   Central nervous system effects:
      TDLo                70 mg/kg
   Dermatitis
Chronic Toxicity

   U.S. Occupational Standard:


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
Animal
rat
mouse
mouse
guinea pig
                     human

                     human
  Route
oral
oral
subcutaneous
oral
                   oral

                   oral
                    TLV:
                                      AIII-219

-------
Methylphenylcarbinol
                                     CHEMICAL NAME
    CAS Number:     98-85-1

    Chemical Name:   a-Methylbenzenemethanol

    Synonyms:
    Molecular
      Formula:
Styralyl alcohol
Phenylmethylcarbinol
1-Phenethyl alcohol

C8H100
                      OH
                      I
    Structure:    CH3 - CH
     Chemical Properties

       Molecular Weight:  122.17

       Vapor Pressure:

       Boiling Point:  204C at 760 mm

       Density:   1.0135 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
1-Phenylethanol
a-Methylbenzyl alcohol
                                  Physical State:    Liquid

                                  Vapor Density:

                                  Melting Point:    20.7C

                                  Solubility:    Insoluble (H2O)
                                          AIII-220

-------
                                                          M ethylpheny Icarbinol
                             PRODUCTION DATA

Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:
                                             *
   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AI11-221

-------
a-Methyl sty rene
                                     CHEMICAL NAME
    CAS Number:   1319-73-9

    Chemical Name:  Methyl styrene

    Synonyms:
a-Methyl styrene
Isopropenyl benzene
a-Phenyl propylene
    Molecular
      Formula:
    Structure:              c=cH2
     Chemical Properties

       Molecular Weight:    118.18

       Vapor Pressure:   1 mm at 7.4C

       Boiling Point:  165.4C at 760 mm

       Density:    0.9106 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:
                                  Physical State:    Liquid

                                  Vapor Density:    4.08

                                  Melting Point:     -23.21C

                                  Solubility:  Insoluble (H2O)
     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
            Fire-moderate
            Explosionmoderate
                                          AIII-222

-------
                                                                  a-Methylstyrene
                              PRODUCTION DATA
Annual U.S.
 Production:   65 x 106 Ibs.
             (1976 capacity)
Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                   Consumption:    50 x 106 Ibs.

                   Fraction of Pro-
                     duction Lost:   0.015
                                TOXICITY DATA
Acute Toxicity
        LD50
        LCLo

 Non-lethal Acute Effects:
        Irritant
        TCLo
        Conjunctivitis
        Dermatitis
4900 mg/kg
3000 ppm
3000 ppm
 600 ppm
 Animal
rat
rat
guinea pig
human
   Route
oral
inhalation
inhalation
inhalation
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA: 100 ppm


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                   TLV:
                                    AIII-223

-------
Mevinphos
                                     CHEMICAL  NAME


    CAS Number:  298-01-1

    Chemical Name:   3-[(Dimethoxyphosphinyl)oxy ] -2-butenoic acid, methyl ester, (E)
    Synonyms:
    Molecular
      Formula:
Mevinphos
2-Carbomethoxy-l-methyl-vinyldimethyl phosphate, a isomer
Phosdrin

C7H,306P
    Structure:
CH3O

CH3O
       O         HO
       II          I    II
       P-O-C = C-C- OCH,
               I              J
               CH
     Chemical Properties

       Molecular Weight: 224.17

       Vapor Pressure:   0.0029 at 21C

       Boiling Point:   99 to 103C at 0.03 mm

       Density:    1.25

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
                                  Physical State:    Liquid

                                  Vapor Density:

                                  Melting Point:

                                  Solubility:  Infinite (H2O)
     Safety Hazard:
                                          AIII-224

-------
                                                                             Mevinphos
Annual U.S.
 Production:

Fraction of
 Dispersion:
                x 106 Ibs.
                               PRODUCTION DATA
                                              Consumption:
             Estimated as 1.0

Release Rate (million Ibs/yr):
 Fraction of Pro-
  duction Lost:   0.015
                                 TOXICITY DATA
Acute Toxicity
        LDSO
                           4mg/kg
                           4 mg/'kg
        LC
          50
                         211jjg/kg
                           4mg/kg
                           3mg/kg
                        4700 /ig/kg
                        7520 Mg/kg
                           3 mg/kg
                          14 ppm (1 hour)
 Animal
rat
rat
rat
rat
mouse
mouse
rabbit
chicken
wild bird
rat
   Route
oral
skin
intraperitoneal
subcutaneous
oral
intraperitoneal
skin
oral
oral
inhalation
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 400 Mg/


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                               TLV:
                                      AIII-225

-------
Mirex
                                       CHEMICAL NAME
     CAS Number:   2385-85,5

     Chemical Name:    l,la,2,2,3,3a>4,5,5,5a,5b,6-Dodecachlorooctahydro-l,3,4-metheno-l H-cyclobuta(cd)
                      pentalene
     Synonyms:     Mirex
                   DodecacMoropentacyclo(3,3,2,02 '6,63 '9,07 (1 ) decane
     Molecular
      Formula:
     Structure:
                   J?
                   Cl
                         \
           Cl -*.       .
              Cl       Cl
Chemical Properties

   Molecular Weight:  545.6

   Vapor Pressure:

   Boiling Point:

   Density:

   Octanol/Water Parti-
    tion Coefficient:

Environmental Persistence

   BOD:

   Atmospheric Reactivity:
                                     Cl
                                   Cl
                                               Cl
                                 . Cl
                                            Cl
                                            _
                                            Cl
                                                      Physical State:     Solid

                                                      Vapor Density:

                                                      Melting Point:     485C (decomposes)

                                                      Solubility:  Insoluble (H2O)
     Safety Hazard:
                                            AIII-226

-------
Annual U.S.
 Production:
                 x 106 Ibs.
                               PRODUCTION DATA
Consumption:
Fraction of
 Dispersion:    Estimated as 1.0

Release Rate (million Ibs/yr):   i
                                               Fraction of Pro-
                                                duction Lost:    0.015
                                 TOXICITY DATA
Acute Toxicity
        LDSO
                         300-600 mg/kg
                         306 mg/kg
 Animal
rat
rat
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogemcity:
        TDLo

   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                         2222 mg/kg (58 weeks)    mouse
                                               TLV:
  Route
oral
oral
                   oral
                                      AIII-227

-------
Monosodium  glutamate
                                    CHEMICAL  NAME


    CAS Number:   14247-2

    Chemical Name:    L - Glutamic acid, monosodium salt

    Synonyms:  Monosodium glutamate
               MSG
               Sodium-L-glutamate
    Molecular
      Formula:  CsH9NO4.Na



                            O              HO
    Structure:     Na     O - C - CH2 - CH2 - C - C -
    Chemical Properties

       Molecular Weight:   170.14                     Physical State:   Solid

       Vapor Pressure:  Negligible at 25C               Vapor Density:

       Boiling Point:   Decomposes                    Melting Point:

       Density:                                     Solubility:   Soluble (7 39 gm/lH2O)

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:     65% of theoretical at 20C for 5 days
                Total theoretical oxygen demand = 1.42 gm/gm
       Atmospheric Reactivity:
    Safety Hazard:
                                         AI11-228

-------
                                                        Monosodium  glutamate
                              PRODUCTION DATA
Annual U.S.
 Production:   47.3 x 106 Ibs.

Fraction of
 Dispersion:   1.0

Release Rate (million Ibs/yr): S1.4
                     Consumption:  49.9 x 106

                     Fraction of Pro-
                       duction Lost: 0.03
                                TOXICITY DATA
Acute Toxicity
     LDSO
Non-lethal Acute Effects:
     Systematic effects:
  Dosage
4253 mg/kg
8000 mg/kg
                          43 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:
      TDLo
   Other Chronic Effects:
   5 mg/kg
 Animal
rat
cat
                     human
TLV:
pregnant mouse
(17 or 18 days)
  Route
intraperitoneal
subcutaneous
                                        oral
parenteral
                                    AIII-229

-------
Morpholine
                                     CHEMICAL NAME
    CAS Number:   110-91-8

    Chemical Name:    Morpholine

    Synonyms:   Tetrahydio-l,4-isoxazine
                Diethethylenimide oxide

    Molecular
      Formula:   C4H9NO
                  H
                   I
           
    Structure:
     Chemical Properties

       Molecular Weight:   87.12                       Physical State:   Liquid

       Vapor Pressure:  10 mm at 23C                  Vapor Density:  3.00

       Boiling Point:    128.3C at 760 mm              Melting Point:   -4.75C

       Density:  1.0005 at 20C/4C                   Solubility:   Infinite (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:    0.9% of theoretical

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:   Fire-moderate
                   Disaster hazarddangeroustoxic fumesNOX
                                           AIII-230

-------
                                                                           Morpholine
                               PRODUCTION DATA
Annual U.S.
 Production:   23.3 x 106 Ibs.

Fraction of
 Dispersion: 0.50

Release Rate (million Ibs/yr):  12.4
                     Consumption:  23.3 x 10 Ibs.

                     Fraction of Pro-
                       duction Lost:  0.03
                                 TOXICITY DATA
Acute Toxicity
      LD50
 Non-lethal Acute Effects:
      Local irritant
      Kidney damage
  Dosage
1050 mg/kg
 500 mg/kg
Animal
rat
rabbit
Chronic Toxicity

   U.S. Occupational Standard:   (aii) TWA 20 ppm (skin)
   Carcinogenicity:
      Neoplastic effects:

   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
6330 mg/kg (28 weeks)   mouse
                     TLV: 20ppm
  Route
oral
skin
                   oral
                                     AIII-231

-------
MSMA
                                     CHEMICAL NAME
    CAS Number:   2163-80-6

    Chemical Name: Methanearsonic acid, monosodium salt

    Synonyms:  MSMA
               Monosodium acid methane arsonate

    Molecular      __ _
      Formula:  CH4AsO,  Na
    Structure:
CH3 - As = O
                          OH
    Chemical Properties

       Molecular Weight:  162.97

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Na^
                                Physical State:  Solid

                                Vapor Density:

                                Melting Point:   161C

                                Solubility:   Very soluble (H2O)
    Safety Hazard:
                                          AIII-232

-------
                                                                              MSMA
Annual U.S.
 Production:   35.0 x 106 Ibs.

Fraction of
 Dispersion:   Estimated as 1.0

Release Rate (million Ibs/yr):  35
                              PRODUCTION DATA
                     Consumption:
                     Fraction of Pro-
                      duction Lost:  0.015
Acute Toxicity
     LDso
                                TOXICITY DATA
1800 mg/kg
  50 mg/kg
 Animal
rat
mammal
  Route
oral
umeported
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:
                                    AI11-233

-------
Nabam


                                      CHEMICAL  NAME


    CAS Number:  142-59-6

    Chemical Name:   Ethylenebis(dithiocaibamic acid), disodium salt

    Synonyms:     Disodium ethylene bisdithiocaibamate
    Molecular
      Formula:     C4H6N2S4-Na
    Structure:
                        H   S

                  CH2 - N - C - S (-) Na (
                        J_   I
                        H   S


     Chemical Properties

       Molecular Weight:  256.4                         Physical State:     Solid

       Vapor Pressure:                                 Vapor Density:

       Boiling Point:                                  Melting Point:     79 to 81C

       Density:                                       Solubility:        Soluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
             Disaster hazaid-dangeious, toxic fumes
                                            AI11-234

-------
                                                                                   Nabam

                               PRODUCTION  DATA
Annual U.S.
 Production:   1.4 x 106 Ibs. (1967)                Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                      duction Lost:   0.015

Release Rate (million Ibs/yr):
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
        LD50            395 mg/kg              rat                 oral
                         580 mg/kg              mouse              oral

 Non-lethal Acute Effects:
        Irritant to skin and mucous membranes
        Narcotic in high concentrations
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:
        Potential carcinogen according to EPA

   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                      AI11-235

-------
Naled



                                      CHEMICAL NAME


    CAS Number:   300-76-5

    Chemical Name:   Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester

    Synonyms:     l,2-Dibromo-2,2-dichloroethyl dimethylphosphate
                   Dimethyl-1,2-dibromo-2,2-dichloroethyl phosphate

    Molecular
      Formula:
                          O       Br Br
                CH30 ^||       ||
    Structure:             p_o-C-C-Cl
                CH30 "         ,    |
                                  H  Cl
     Chemical Properties

        Molecular Weight:  380.7               .     ,    Physical State:     Solid

        Vapor Pressu re:                                 Vap or Density:

        Boiling Point:                                  Melting Point:     270C

        Density:                                       Solubility:  Insoluble (H2O (hydrolyzes)

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOO:

        Atmospheric Reactivity:
     Safety Hazard:
                                            AIII-236

-------
                                                                                  Naled


                              PRODUCTION DATA
Annual U.S.
 Production:    2.0 x 106 Ibs.                      Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:    1-0                               duction Lost:    0.015

Release Rate (million Ibs/yr): 2.0
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
        LD50           250 mg/kg            tat                 oral
                        800mg/kg            rabbit               skin
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 3 mg/m3



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AIII-237

-------
Naphtha (solvent)
                                      CHEMICAL  NAME
     CAS Number:  MX 8030-31-7

     Chemical Name:   Coal tar naphtha

     Synonyms:    Solvent naphtha
                  Heavy naphtha
                  Hiflash naphtha
     Molecular
      Formula:
     Structure:     (Mixture of xylene and higher homologs)
     Chemical Properties

        Molecular Weight:                               Physical State:    Liquid

        Vapor Pressure:                                 Vapor Density:

        Boiling Point:  160 to 220C                     Melting Point:

        Density:    0.885 to 0.970                       Solubility:

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
             Reacts with oxidizing materials
             Common air contaminant
     Safety Hazard:
             Fire-dangerous
             Explosion-slight
                                           AIII-238

-------
                                                                Naphtha  (solvent)
                              PRODUCTION DATA
Annual U.S.
 Production:   8288.4 x 106 Ibs.                  Consumption:     8288.4 x 106 Ibs.
Fraction of
 Dispersion:   l-

Release Rate (million Ibs/yr):  8371.3
                     Fraction of Pro-
                      duction Lost:    0.01
Acute Toxicity
        TOXICITY DATA

  Dosage               Animal
1600ppm              rat
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:   Recognized carcinogen


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                     TLV:  100 ppm
  Route

inhalation
                                     AIII-239

-------
Naphthalene
                                     CHEMICAL NAME
    CAS Number:   91-20-3

    Chemical Name:    Naphthalene

    Synonyms:    Napthene
    Molecular
      Formula:
    Structure:
     Chemical Properties

       Molecular Weight:  128.19                      Physical State:     Solid

       Vapor Pressure: 0.2129 mm at 25C               Vapor Density:    4.42

       Boiling Point:   218C                         Melting Point:     80.55C

       Density:    1.0253 at 20C/4C                 Solubility:  Insoluble (H2O)

       Octanol/Water Parti-
         tion Coefficient:  3.27

     Environmental Persistence

       BOO:   Total theoretical oxygen demand:  3gm/gm

       Atmospheric Reactivity:
             Reacts with oxidizing materials
             Activity toward OH: .tw = 2.5 days
                           03:  tv4 = 1 year
                           ROj: unieactive
           .  Minor contaminant in air
     Safety Hazard:
             Fire -moderate
             Explosion-moderate
                                          AIII-240

-------
                                                                          Naphthalene
                               PRODUCTION DATA
Annual U.S.
 Production:   143 x 106 Ibs. (1975)

Fraction of
 Dispersion:    0.02

Release Rate (million Ibs/yr):  16.9 (unspecified year)
                      Consumption:    140 x 106 Ibs. (1975)

                      Fraction of Pro-
                       duction Lost:    0.01
                                 TOXICITY DATA
Acute Toxicity
        LDSO
        LE>Lo
 Non-lethal Acute Effects:
        Nausea
        Anemia
        Liver damage
        Convulsions
        Coma
1780 mg/kg
 100 mg/kg
 150 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 10 ppm
 Animal
rat
child
mouse
  Route
oral
oral
intraperitoneal
   Carcinogenicity:
        Neoplasm
           TDLo
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
   3500 mg/kg (98 days intermittent)
                      tLV:    10 ppm
                                     AIII-241

-------
a-Naphthalenesulfonic  acid
                                    CHEMICAL  NAME
    CAS Number:    85-47-2

    Chemical Name:     1-Naphthalenesulfonic acid

    Synonyms:
    Molecular
      Formula:   Ci0H8O3S
                        SO,H
    Structure:
    Chemical Properties

       Molecular Weight:   208.25

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
           Disastet hazard-dangerous, toxic fumes of SOX
Physical State:   Solid

Vapor Density:

Melting Point:   139tol40C

Solubility:    Soluble (H2O)
                                         AIII-242

-------
                                                a-Naphthalenesulfonic acid
                            PRODUCTION DATA

Annual U.S.
 Production:                                 Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                   duction Lost:

Release Rate (million Ibs/yr):
                              TOXICITY DATA

Acute Toxicity              Dosage             Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                  AIII-243

-------
B-Naphthalenesulfonic acid
                                    CHEMICAL  NAME
    CAS Number:   120-18-3

    Chemical Name:    2-Naphthalenesulfonic acid

    Synonyms:     Naphthalene-2-sulfonic acid
    Molecular
     Formula:
    Structure:
    Chemical Properties

       Molecular Weight:  208.25

       Vapor Pressure:

       Boiling Point:   Decomposes

       Density:     1.441 at 25C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
            Disaster hazard-dangerous, toxic fumes of SOX
Physical State:    Solid

Vapor Density:

Melting Point:     124tol25C

Solubility:   Very soluble (H2O)
                                         AIII-244

-------
                                                B-Naphthalenesulfonic acid
                             PRODUCTION DATA

Annual U.S.
 Production:  39.0 x 106 ibs. (1968)               Consumption:

Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:  0.015

Release Rate (million Ibs/yr):
                               TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
       LDSo           400 mg/kg             tat               oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                             TLV:

   Other Chronic Effects:
                                   AIII-245

-------
a-Naphthol



                                     CHEMICAL NAME


    CAS Number:   90-15-3

    Chemical Name:    1-Naphthol

    Synonyms:     1-Hydioxynaphthalehe


    Molecular
      Formula:     Ci0H8O


                       OH


    Structure:
    Chemical Properties

       Molecular Weight:  144.19                      Physical State:     Solid

       Vapor Pressure: l mm at 94C                   Vapor Density:

       Boiling Point:   288C (sublimes) at 760 mm       Melting Point:     96C

       Density:    1.0989 at 99C/4C                Solubility:   Insoluble (H2O)
                                                               Slightly soluble (hot HjO)
       Octanol/Water Parti-
        tion Coefficient:  2.98

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
             Fiie-slight
                                          AIII-246

-------
                                                                           a-Naphthol
                               PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage               Animal               Route
        LDSO           2590mg/kg            rat                 oral
                         880 mg/kg            rabbit               skin

Non-lethal Acute Effects:
        Nephritis
        Circulatory collapse
        Anemia
        Convulsions
        Injury to cornea and lens of eye
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AI11-247

-------
B-Naphthol
                                     CHEMICAL  NAME
    CAS Number:   135-19-3

    Chemical Name:    2-Naphthol
    Synonyms:
    Molecular
      Formula:
2-Hydroxy naphthalene
Naphthol B
C10H80
    Structure:
    Chemical Properties

       Molecular Weight:  144.19

       Vapor Pressure: 15 mm at 128.6C

       Boiling Point:   295C at 760 mm

       Density:    1.28at20C

       Octanol/Water Parti-
         tion Coefficient:     2.89

    Environmental Persistence

       BOO: 93% of theoretical after 12 days

       Atmospheric Reactivity:
    Safety Hazard:
             Fire-slight
                                  Physical State:     Solid

                                  Vapor Density:    4.97

                                  Melting Point:     123 to 124C

                                  Solubility:   Insoluble (H2O)
                                             Slightly soluble (hot H2O)
                                           AIII-248

-------
                                                                           B-Naphthol
                               PRODUCTION DATA
              (none in 1975 or 1976)
Annual U.S.
 Production:

Fraction of
 Dispersion:
Release Rate (million Ibs/yr):
Consumption:

Fraction of Pro-
 duction Lost:
0.1 xlOlbs. (1975)
                                 TOXICITY DATA
Acute Toxicity               Dosage
        LDSO            2420 mg/kg
        LDLo            2940 mg/kg
                          100 mg/kg
                         3800 mg/kg
                         2670 mg/kg

Non-lethal Effects:
        Nephritis
        Circulatory collapse
        Anemia
        Convulsions
        Damage to cornea and lens of eye
                                               Animal
                                              rat
                                              rat
                                              mouse
                                              rabbit
                                              guinea pig
                     Route
                   oral
                   subcutaneous
                   subcutaneous
                   oral
                   subcutaneous
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                              TLV:
                                      AIII-249

-------
1-Naphthylamine
                                     CHEMICAL NAME
    CAS Number:    134-32-7

    Chemical Name:     l-Naphthylamine

    Synonyms:   a-Naphthylamine
    Molecular
      Formula:   C10H9N
    Structure:
    Chemical Properties

       Molecular Weight:     143.20                   Physical State:      Solid

       Vapor Pressure:  1 mm at 104.3C                Vapor Density:  4.93

       Boiling Point:   300.8C at 760 mm               Melting Point:   50C

       Density:  1.1229 at 25C/25C                   Solubility:   Slightly (H2O)

       Octanol/Water Parti-
         tion Coefficient:   2.22

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:   Reacts with oxidizing materials
     Safety Hazard:
           Fire-slight-toxic fumes
                                          AIII-250

-------
                                                                  1-Naphthylamine
                              PRODUCTION DATA
Annual U.S.
 Production:

Fraction of
 Dispersion:
I.lxl06lbs. (1963)
Consumption:

Fraction of Pro-
 duction Lost:
                                                0.015
Release Rate (million Ibs/yr):
                                 TOXICITY DATA
Acute Toxicity
      LD50
            Dosage
           779 mg/kg
           300 mg/kg
         4000 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
      Urinary bladder cancer
         TDLo            400 mg/kg
      Neoplastic effects:
         TDLo             25 mg/kg
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
 Animal
 rat
 rabbit
 mammal
  Route
oral
subcutaneous
oral
                                dog
                               TLV:
                   subcutaneous

                   subcutaneous
                                     AIII-251

-------
2-Naphthylamine
                                    CHEMICAL  NAME
    CAS Number:   91-59-8

    Chemical Name:    2-Naphthylamine

    Synonyms:   0-Naphthylamine
    Molecular
      Formula:
    Structure:
                             NH-
    Chemical Properties

       Molecular Weight:   143.20

       Vapor Pressure:  1 mm at 108C

       Boiling Point:   306.1C

       Density:   1.0614 at 98C/4C

       Octanol/Water Parti-
         tion Coefficient:   2.25

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Fire-moderate-toxic fumes
Physical State:      Solid

Vapor Density:

Melting Point:   113C

Solubility:   Soluble (H2O)
           (Very soluble in hot H2O)
                                           AIII-252

-------
                                                                   2-Naphthylamine
                               PRODUCTION DATA
               1.28xl06lbs. (1955)
Annual U.S.
 Production:

Fraction of
 Dispersion:
Release Rate (million Ibs/yr):
Consumption:

Fraction of Pro-
 duction Lost:
                                                               0.015
                                 TOXICITY DATA
Acute Toxicity
      LDSO
                           Dosage
                         727 mg/kg
                         200 mg/kg
                         500 mg/kg
 Animal
 rat
 mouse
 dog
  Route
oral
intraperitoneal
unknown
Chronic Toxicity

   U.S. Occupational Standard:   Carcinogen
   Carcinogenicity:
      TDLo
      Neoplastic effects:
         TDLo
   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                          118 mg/kg (78 weeks)
                         2120 mg/kg (52 weeks)
                           18 mg/kg
                         3900 mg/kg (2 years)
                           14 mg/kg (240 weeks)
                          365 gm/kg (43 weeks)

                           31 gm/kg (1 year)
                           42 mg/kg
                          260 mg/kg (43 weeks)
 rat
 mouse
 mouse
 dog
 monkey
 hamster

 rat
 mouse
 hamster
                                               TLV:
subcutaneous
subcutaneous
parenteral
oral
oral
oral

oral
subcutaneous
oral
                                     AIII-253

-------
Naptalam
                                     CHEMICAL  NAME
    CAS Number:   132-67-2

    Chemical Name:    2-[(l-Naphthalenylamino)carbonyl]benzole acid, monosodium salt

    Synonyms:  N-Naphthyl phthalatnic acid, sodium salt
    Molecular
      Formula:  C18H13NO3-Na
    Structure:
    Chemical Properties

       Molecular Weight:     291.3

       Vapor Pressure:

       Boiling Point:

       Density:    1.40 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:    Solid

Vapor Density:

Melting Point:    185C

Solubility:   0.2 gm/100 ml H2O
    Safety Hazard:
          Fire-moderate
                                          AIII-254

-------
                                                                             Naptalam
Annual U.S.
 Production:

Fraction of
 Dispersion:
              2.0 x 106 Ibs.
              Estimated as 1

Release Rate (million Ibs/yr):    2
                               PRODUCTION DATA
Consumption:

Fraction of Pro-
 duction Lost:
0.015
                                 TOXICITY DATA
Acute Toxicity
      LD50
                           Dosage
                        1770 mg/kg
                         > 5 mg/kg
 Animal
rat
dog
Non-lethal Acute Effects:
      Relatively non-toxic to warm-blooded animals
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                              TLV:
     Route
   oral
   oral
                                     AIII-255

-------
Neopentanoic acid
                                    CHEMICAL  NAME
    CAS Number:    75-98-9

    Chemical Name:    Pivalic acid

    Synonyms:   Neopentanoic acid
                2,2-Dimethyl propanoic acid
                Trimethyl acetic acid
    Molecular
      Formula:   C5H10O2
                       CH,
                      ---
    Structure:     CH3 - C - C
                       i__   X OH
                       CH3
    Chemical Properties

       Molecular Weight:      102.13                   Physical State:     Solid

       Vapor Pressure:                                Vapor Density:

       Boiling Point:   163.7 to 163.8Cat760 mm       Melting Point:   35.3 to 35.5C

       Density:   0.905 at 50C                        Solubility:   Slightly (H2O)

       Octanol/Water Parti-
        tion Coefficient:   1.60

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                          AIII-256

-------
                                                              Neopentanoic acid
                             PRODUCTION DATA

Annual U.S.
 Production:  5 x 10 Ibs. (1975 capacity            Consumption:
            for neo-acids)
Fraction of                                   Fraction of Pro-
 Dispersion:                                    duction Lost:  0.015

Release Rate (million Ibs/yr);
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
      LDLo              5000mg/kg            rat                oral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AIII-257

-------
Nitrilotriacetic  acid,  trisodium  salt
                                     CHEMICAL  NAME


    CAS Number:  5064-31-3

    Chemical Name:    N,N-bis(carboxymethyl)glycine, trisodium salt
Synonyms:
    Molecular
      Formula:
                  NTA, trisodium salt
                  Triglycine, trisodium salt
TGA, trisodium salt
Triglycolamic acid, trisodium salt
                           O
                                          O
    Structure:    Na(+)(~)0 - C - H2C - N - CH2 - C - O(  } Na(+)
                                 CH2-C- i
                                           O
                                                   Na
                                                      (+)
    Chemical Properties

       Molecular Weight:     260.13

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:    76% of theoretical after 20 days at 20 C
                Total theoretical oxygen demand = 0.93 gm/gm
       Atmospheric Reactivity:
                                                Physical State:     Solid

                                                Vapor Density:

                                                Melting Point:

                                                Solubility:
                 Acid form -240 C with
                 decomposition
              Soluble (H2O)
    Safety Hazard:
          Fire combustible
                                          AIII-258

-------
                                        Nitrilotriacetic acid, trisodium salt
                              PRODUCTION DATA
Annual U.S.
 Production:    85 x 106 Ibs.

Fraction of
 Dispersion:    1.0

Release Rate (million Ibs/yr):    14.3
                      Consumption:   13xl06lbs.

                      Fraction of Pro-
                       duction Lost:     0.015
                                 TOXICITY DATA
Acute Toxicity
     LD50
1100 mg/kg
 254 mg/kg
 681 mg/kg
 750 mg/kg
 Animal
rat
rat
mouse
monkey
  Route
oral
intra peritoneal
oral
oral
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
       (Nitrilotriacetic acid is a confirmed carcinogen, causing
         urinary tract cancers in rats and mice.)
   Mutagenicity:

   Teratogenicity:     Birth abnormalities may result   TLV:
                   from ingest ion
   Other Chronic Effects:
                                    AIII-259

-------
p-Nitroaniline
                                     CHEMICAL NAME
    CAS Number:      100-01-6

    Chemical Name:    p-Nitroaniline

    Synonyms:  l-Amino-4-nitrobenzene
               Fast red 2G base
    Molecular
      Formula:
    Structure:
                           ,- NH2
    Chemical Properties

       Molecular Weight:     138.13

       Vapor Pressure: 1 mm at 142.4C

       Boiling Point:   331.73C

       Density:    1.424 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:  1-41

    Environmental Persistence

       800:

       Atmospheric Reactivity:
    Safety Hazard:
          Fire-slight
Physical State:     Solid

Vapor Density:

Melting Point:  148.5 to 149.5C

Solubility:  Insoluble (H2O)
           (Slightly in hot H2O)
                                           AIII-260

-------
                                                                        p-Nitroaniline
                               PRODUCTION DATA
Annual U.S.
 Production:   8.17 x 106 Ibs. (1967)

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                     Consumption:

                     Fraction of Pro-
                       duction Lost:
                0.015
                                 TOXICITY DATA
Acute Toxicity
      LDLo

 Non-lethal Acute Effects:
      Cyanosis
      Nausea and vomiting
      Convulsions
  Dosage
3249 mg/kg
 812mg/kg
 250 mg/kg
  75 mg/kg
  40 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:  (air) 1 ppm (skin)



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
      Liver damage
Animal
rat
mouse
mouse
wild bird
mammal
  Route
oral
oral
intraperitoneal
oral
intravenous
                     TLV:   1 ppm (skin)
                                      AIII-261

-------
Nitroanisole
                                    CHEMICAL  NAME
    CAS Number:   100-17-4

    Chemical Name:    1-Methoxy^-nitrobenzene

    Synonyms:
    Molecular
     Formula:  C7H7NO3
    Structure:
    Chemical Properties

       Molecular Weight:     153.14                   Physical State:     Solid

       Vapor Pressure:                                Vapor Density:

       Boiling Point:   276.8C at 757 mm              Melting Point:  54C

       Density:  1.2192at60C/4C                    Solubility:   Insoluble (H2O)

       Octanol/Water Parti-
        tion Coefficient:  2.03

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
                                          AIII-262

-------
                                                                        Nitroanisole
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
      LDSO              4700 mg/kg            mammal (unspecified)  oral
                        1400 mg/kg            mammal (unspecified)  intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                     AIII-263

-------
Nitrobenzene
                                      CHEMICAL  NAME
    CAS Number:

    Chemical Name:
              98-95-3

              Nitrobenzene
    Synonyms:  Oil of mirbane
                Nitrobenzol
                Mononitrobenzene
    Molecular
      Formula:  C6HSNO2
                         N02
     Chemical Properties

       Molecular Weight:     123.06

       Vapor Pressure: 0.284 mm at 25C

       Boiling Point:  210.8C at 760 mm

       Density:     1.2037 at 20 C/4C

       Octanol/Water Parti-
         tion Coefficient:     1.88
                                             Artificial oil of bitter almonds
                                             Solvent black 5
                                             Nigrosine spirit soluble B
                                             Physical State:     Solid/oily liquid

                                             Vapor Density:    4.25

                                             Melting Point:  5.7C

                                             Solubility:  Slightly (1 gm/100 ml H2O at 20C)
     Environmental Persistence

        BOD:    Total theoretical oxygen demand = 1 .95 gm/gm
Atmospheric Reactivity:
  Biodegradable
  Unreactive to 03 (tyi =11 years) and ROj
  OH: tw = 3 days
     Safety Hazard:
          Fire -moderate
          Explosion - moderate
          Disaster hazard-moderatetoxic fumes-NO,
                                                   2000 years)
                                           AIII-264

-------
                                                                          Nitrobenzene
                                PRODUCTION DATA

Annual U.S.
 Production:      551.2 x 106 Ibs. (1974)            Consumption:  551.2 x 106 Ibs.
Fraction of
 Dispersion:    0.03

Release Rate (million Ibs/yr):    19-3
                                               Fraction of Pro-
                                                 duction Lost:    0.012
Acute Toxicity
                                  TOXICITY DATA

                            Dosage               Animal               Route
                          800 mg/kg            rat                  subcutaneous
                          400 mg/kg            mouse               skin
                          480 mg/kg            mouse               subcutaneous
                          750 mg/kg            dog                 oral
                          150 mg/kg            dog                 intravenous
                         2000 mg/kg            cat                  oral
                          700 mg/kg            rabbit               oral
                          600 mg/kg            rabbit               skin
                         1000 mg/kg            mammal             oral
                                               (unspecified)
                        ca. 80 mg/kg            human               oral
Non-lethal Acute Effects:
      Blood effects
        TDj_,0             200 mg/kg            human female         oral
      Cyanosis due to formation of methemoglobin
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 1 ppm (skin)



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:    125 mg/kg subcutaneous        TLV:    5 mg/m3 (1 ppm)
      In rat, caused delayed embryogenesis, embryo malformation and death
   Other Chronic Effects:
      Heart, liver and kidney damage
      CNS effects
                                      All1-265

-------
p-Nitrobenzoic acid
                                     CHEMICAL  NAME
    CAS Number:   62-23-7

    Chemical Name:    p-Nitrobenzoic acid

    Synonyms:  4-Nitrobenzoic acid
    Molecular
      Formula:  C7H5NO4
    Structure:
                              C  -  OH
                              II
                              o
    Chemical Properties

       Molecular Weight:    167.12

       Vapor Pressure:    <10 mm at 25C

       Boiling Point:   Sublimes

       Density:    1.610 at 20C

       Octanol/Water Parti-
         tion Coefficient:  2.03

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Physical Stafe:    Solid

Vapor Density:

Melting Point:   242C

Solubility:   Insoluble (H2O)
    Safety Hazard:
          Diaster hazarddangerous toxic fumes-NOx
                                           AIII-266

-------
                                                              p-Nitrobenzoic acid
                              PRODUCTION DATA

Annual U.S.
 Production:                                   Consumption:

Fraction of                                    fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
     LDSO               1960 mg/kg            rat                oral
                        1210mg/kg            rat                intraperitoneal
                        1960 mg/kg            rat                parenteral
                         880 mg/kg            mouse             intraperitoneal
                         770 mg/kg            mouse             intravenous
                        1470 mg/kg            mouse             parenteral
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                    AIII-267

-------
Nitrocellulose
                                      CHEMICAL NAME
     CAS Number:     9004-70-0

     Chemical Name:      Nitrate cellulose
    Synonyms:
Nitrocellulose
Cellulose nitrate
Celloidin
Pyroxylin
Collodion
    Molecular	
      Formula:   (C6H7N3bu)n
    Structure:
                  .O
                 I-  O2NO

     Chemical Properties

        Molecular Weight:     (297.13)n

        Vapor Pressure:    Negligible at 25C

        Boiling Point:

        Density:    1-66

        Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

        BOD:

        Atmospheric Reactivity:
     Safety Hazard:
             Fire-highly dangerous
             Explosion-moderately dangerous
                                                             n=>2
                                   Physical State:    Solid

                                   Vapor Density:

                                   Melting Point:

                                   Solubility:     Insoluble (H2O)
                                            AIII-268

-------
                                                                    Nitrocellulose
                             PRODUCTION DATA

Annual U.S.
 Production:   50xl06lbs.                     Consumption:  50xl06lbs.

Fraction of                                   Fraction of Pro-
 Dispersion:   !-                               duction Lost:   0.03

Release Rate (million Ibs/yr):    51.5
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
        Low toxicity
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                   AIII-269

-------
Nitrpethane
                                     CHEMICAL NAME
    CAS Number:    79-24-3

    Chemical Name:     Nitroethane

    Synonyms:
    Molecular
      Formula:   C2HSNO2
    Structure:    CH3 - CH2 - NO2
    Chemical Properties

       Molecular Weight:  75.08

       Vapor Pressure:  20.3 mm at 25C

       Boiling Point:    115C at 760mm

       Density:  1.0448 at 25C/4C

       Octanol/Water Parti-
         tion Coefficient:  0.18

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
Physical State:  Liquid

Vapor Density:  2.58

Melting Point:  -50C

Solubility:    Slightly (H2O)
    Safety Hazard:
           Fire-moderate
           Explosion-dangerous
           Disaster hazarddangeroustoxic fumes NOX
                                          AIII-270

-------
                                                                         Nitroethane
                              PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage              Animal               Route
      LDSO               1100mg/kg            rat                 oral
                          860 mg/kg            mouse              oral
      LDLo                500 mg/kg            rabbit              oral

 Non-lethal Acute Effects:
      Local irritant to eyes and respiratory tract
      Dermatitis
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:   100 ppm

   Other Chronic Effects:
                                     AIII-271

-------
Nitroglycerine
                                      CHEMICAL  NAME
    CAS Number:

    Chemical Name:

    Synonyms:
                 55-63-0

                 Nitroglycerine
              Ethylene glycol trinitrate
              Glycerol trinitrate
              Trinitrin
Molecular
 Formula:  C3HSN3O9
               H2 - C - O - N02

    Structure:   H - C - O - NO2

                 H2C - O - NO2



    Chemical Properties

       Molecular Weight:     227.09

       Vapor Pressure:    1 mm at 127C

       Boiling Point:   256C (explodes)

       Density:    1.5931 at 20 C/4C

       Octanol/Water Parti-
         tion Coefficient:     0.35

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
          Fire-dangerous
          Explosion-severe
          Disaster hazard-very dangerous-toxic fumes
GMT
NT
                                                Physical State:     Liquid

                                                Vapor Density:    7.84

                                                Melting Point:  13C

                                                Solubility:  Slightly (H2O)
                                           AIII-272

-------
                                                                        Nitroglycerine
                               PRODUCTION DATA

Annual U.S.
 Production:                         "^         Consumption:

Fraction of                                      Fraction of Pro-
 Dispersion:                                       duction Lost:

Release Rate (million Ibs/yr):
                                  TOXICITY DATA

Acute Toxicity               Dosage               Animal              Route
     LDLo                80 rng/kg              rat                 oral
                          40 mg/kg              rabbit               intravenous
                        275 mg/kg              rat                 intramuscular
                        150 mg/kg              cat                 subcutaneous
                        400 mg/kg              rabbit               subcutaneous
                        450 mg/kg              rabbit               intramuscular

Non-lethal Acute Effects:
     Respiratory paralysis
     Skin irritation
     Vomiting
Chronic Toxicity

   U.S. Occupational Standard: (air) 2 mg/m3 (skin)



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:   2 mg/m3

   Other Chronic Effects:
                                      AIII-273

-------
Nitromethane
                                     CHEMICAL  NAME
    CAS Number:   75-52-5

    Chemical Name:  Nitromethane

    Synonyms:     Nitrocarbol
    Molecular
      Formula:  CH3NO2
    Structure:    H  -
H
 I
C -  NO2
 I
H
     Chemical Properties

       Molecular Weight:    61.04

       Vapor Pressure:   36.27 mm at 25C

       Boiling Point:   100.8C at 760 mm

       Density:    1.1371 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:    0.17

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:  Reacts with oxidizing materials
     Safety Hazard:
          Firedangerous
          Explosion - moderate
          Disaster hazarddangerous-toxic fumes of NOX
                               Physical State:     Liquid

                               Vapor Density:    2.11

                               Melting Point:  -17C

                               Solubility:  Soluble (H2O)
                                           AIII-274

-------
                                                                       Nitromethane
                              PRODUCTION DATA

Annual U.S.
 Production:                                    Consumption:

Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity               Dosage              Animal               Route
     LDSO               940 mg/kg             rat                 oral
                        950 mg/kg             mouse              oral
     LDLo               125 mg/kg             dog                oral
                        565 mg/kg             dog                subcutaneous
                        800 mg/kg             dog                intravenous
                        750 mg/kg             rabbit              oral
                        750 mg/kg             rabbit              intravenous
     LCLo              2446 mg/m3            monkey             inhalation
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 100 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:   100 ppm

   Other Chronic Effects:
     Nausea
     Vomiting
     Kidney and liver damage
     Irritates eyes
                                    AIII-275

-------
m-Nitrophenol
                                     CHEMICAL  NAME
    CAS Number:   554-84-7

    Chemical Name:    3-Nitrophenol

    Synonyms:


    Molecular
      Formula:  C6HSNO2
                   OH
    Structure:
                        NO,
    Chemical Properties

       Molecular Weight:   139.11

       Vapor Pressure:  10 mm at 25C

       Boiling Point:   194C at 70 mm

       Density:     1.2797 at 100C/4C

       Octanol/Water Parti-
        tion Coefficient:     2.05

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
          Disaster hazard-dangerous-toxic fumes-NOx
Physical State:  Solid

Vapor Density:

Melting Point:   97C

Solubility:   Slightly (H2O)
           (Very soluble in hot H2O)
                                          AIII-276

-------
                                                                      m-Nitrophenol
                              PRODUCTION DATA

Annual U.S.
 Production:    14.8 x 106 Ibs.                    Consumption:
              (1967 all nitiophenols)
Fraction of                                    Fraction of Pro-
 Dispersion:                                     duction Lost:     0.015

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity              Dosage              Animal              Route
      LDSO               447 mg/kg            rat                oral
                        1414 mg/kg            mouse              oral
                          83 mg/kg            dog                intravenous
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                    All1-277

-------
o-Nitrophenol
                                     CHEMICAL NAME
    CAS Number:    88-75-5

    Chemical Name:     o-Nitrophenol

    Synonyms:   2-Hydroxynitrobenzene
    Molecular
     Formula:   C6HSNO3
                   OH
    Structure:
                         NCX,
    Chemical Properties

       Molecular Weight:   139.11

       Vapor Pressure:  1 mm at 49.3

       Boiling Point:   216Cat760mm

       Density:   1.485 at 14c

       Octanol/Water Parti-
        tion Coefficient:   3-58

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:  Solid

Vapor Density:

Melting Point:   45.3 to 45.7C

Solubility:    Slightly (H2O)
    Safety Hazard:
          Diaster hazard-dangerous-toxic fumes NOX
                                          AIII-278

-------
                                                                       o-Nitrophenol
                              PRODUCTION DATA

Annual U.S.
 Production:    14.8 x 106 Ibs.                    Consumption:
              (1967 all nitrophenols)
Fraction of                                     Fraction of Pro-
 Dispersion:                                     duction Lost:  0.015

Release Rate (million Ibs/yr):
                                 TOXICITY DATA

Acute Toxicity              Dosage              Animal               Route
      LD50              2828mg/kg            rat                 oral
                         1297 mg/kg            rat                 oral
      LDL0               100 mg/kg            dog                intravenous

 Non-lethal Acute Effects:
      Liver and kidney damage
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                                TLV:

   Other Chronic Effects:
                                     AIII-279

-------
p-Nitrophenol
                                     CHEMICAL NAME
    CAS Number:   100-02-7

    Chemical Name:   p-Nitrophenol
                    4-Nitrophenol
    Synonyms:
    Molecular
      Formula:  C6HSNO3
    Structure:
    Chemical Properties

       Molecular Weight:  139.11

       Vapor Pressure:

       Boiling Point:  279C (decomposes)

       Density:     1.479 at 20C

       Octanol/Water Parti-
        tion Coefficient:     1.97

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
         Disaster hazaid-dangerous-toxic fumes-NOx
Physical State:    Solid

Vapor Density:

Melting Point:  114.9 to 115.6C

Solubility:  Slightly (H2O)
                                          AIII-280

-------
                                                                         p-Nitrophenol
                               PRODUCTION DATA
Annual U.S.
  Production:   52 x 106 Ibs. (1976 capacity)

Fraction of
  Dispersion:

Release Rate (million Ibs/yr):
                    Consumption:

                    Fraction of Pro-
                     duction Lost:  0.015
                                  TOXICITY DATA
Acute Toxicity
      LDSO
     LDLo
Non-lethal Acute Effects:
     Hyperthermia
     Methemoglobinemia
     CNS depression
Dosage
350 mg/kg
467 mg/kg
 75 mg/kg
150 mg/kg
 65 mg/kg
 10 mg/kg
500 mg/kg
 Animal
rat
mouse
mouse
cat
pigeon
dog
dog
   Route
oral
oral
intraperitoneal
intiaperitoneal
intramuscular
intravenous
intraperitoneal
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                    TLV:
                                     AIII-281

-------
l-Nitropropane
                                    CHEMICAL  NAME
    CAS Number:    108-03-2

    Chemical Name:    1-Nitropropane

    Synonyms:
    Molecular
     Formula:    C3H7NO2
    Structure:    CH3 - CH2.- CH2 - NO2
    Chemical Properties

       Molecular Weight:   81.11                       Physical State:      Liquid

       Vapor Pressure:  9.87 mm at 25C                Vapor Density:  3.06

       Boiling Point:   130.5 to 131.5C at 760mm       Melting Point:   -108C

       Density:   1.0081 at 24C/4C                   Solubility:   Slightly (H2O)

       Octanol/Water Parti-
        tion Coefficient:   2-4l

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Fire-moderate
          Explosion-dangerous
          Disaster hazarddangerous-toxic fumes NOX
                                         AIII-282

-------
                                                                   l-Nitropropane
Annual U.S.
 Production:

Fraction of             .
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                                            Consumption:

                                            Fraction of Pro-
                                             duction Lost:
                               TOXICITY DATA
Acute Toxicity
      LDSO
      LDLo
Non-lethal Acute Effects:
     Irritation of eyes
     Vomiting
  Dosage
 800 mg/kg
 250 mg/kg
1000 mg/kg
                                              Animal
                                              mouse
                                              rabbit
                                              rat
                                                                Route
                                                               oral
                                                               oral
                                                               oral
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 25 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                            TLV:  25 ppm
                                   AIII-283

-------
2-Nitropropane
                                     CHEMICAL  NAME
    CAS Number:      79-46-9

    Chemical Name:    2-Nitropropane

    Synonyms:  Isonitropropane
    Molecular
      Formula:  C3H7NO2
                      NO,
    Structure:    CH3 - C - CH3

                      H
     Chemical Properties

       Molecular Weight:  89.09

       Vapor Pressure:    17.42 mm at 25C

       Boiling Point:   120C at 760mm

       Density:    0.9876 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
Physical State:    Liquid

Vapor Density:    3.06

Melting Point:  -93C

Solubility:  Slightly (H2O)
     Safety Hazard:
          Firemoderate
          Explosion-dangerous
          Disaster hazarddangeroustoxic fumesNOX
                                          AIII-284

-------
                                                                      2-Nitropropane
Annual U.S.
  Production:

Fraction of
  Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                       Consumption:

                       Fraction of Pro-
                        duction Lost:
Acute Toxicity
     LCLo
 500 mg/kg
  75 mg/kg
 500 mg/kg
1513 ppm (5 hours)
 714 ppm (5 hours)
2381 ppm (5 hours)
4622 ppm (5 hours)
Non-lethal Acute Effects:
     Central nervous system effects
       TDLo               15 ppm
     Local irritant
     Vomiting
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 25 ppm


   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                                  TOXICITY DATA
 Animal
rat
mouse
rabbit
rat
cat
rabbit
guinea pig
                      human
   Route
oral
intraperitoneal
oral
inhalation
inhalation
inhalation
inhalation
                                         inhalation
                       TLV:   25 ppm
                                      AIII-285

-------
N-Nitrosodiethylamine
                                    CHEMICAL  NAME
    CAS Number:  55-18-5

    Chemical Name:   N-Nitrosodiethylamine

    Synonyms:


    Molecular
      Formula:  C4Hi0N2O
    Structure:
                 CH3 - CH2
                 CH3 - CH2
N-N = O
    Chemical Properties

       Molecular Weight:    102.14

       Vapor Pressure:

       Boiling Point:  176.9Cat 760mm

       Density:    0.9422 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
                    Physical State:     Liquid

                    Vapor Density:

                    Melting Point:

                    Solubility:  Soluble (H2O)
                                         All1-286

-------
                                                            N-Nitrosodiethylamine
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
Acute Toxicity
     Lbso
         TOXICITY DATA

  Dosage               Animal
216 mg/kg             rat
 11 mg/kg             rat
157 mg/kg             rat
246 mg/kg             hamster
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
      TD
        'LO
   Mutagenicity:

   Teratogenicity:
      TDLo
   Other Chronic Effects:
 45 mg/kg (83 weeks)    rat
100 mg/kg             rat
200 mg/kg (10-21 days   rat
   pregnant)
 40 mg/kg             rat
 57 mg/kg             mouse
560 mg/kg             dog
 18 gm/kg             monkey
  2 gm/kg             monkey
960 mg/kg (28 weeks)    rabbit
750 mg/kg (2.2 years)    pig
                      TLV:
150 mg/kg (22 days      rat
   pregnant)
 19 gm/kg (15-20 days   mouse
   pregnant)
 17 mg/kg (pregnant)     hamster
  Route
oral
intraperitoneal
intravenous
unknown
oral
intraperitoneal
subcutaneous

intravenous
oral
oral
oral
intraperitoneal
oral
oral
intravenous

unknown

subcutaneous
                                     AIII-287

-------
N-Nitrosodimethylamine
                                    CHEMICAL  NAME
    CAS Number:   62-75-9

    Chemical Name:    N-Nitrosodimethylamine

    Synonyms:  Dimethylnitrosamine
               Nitrous dimethyl amide

    Molecular   C2H6N2O
      Formula:
    Structure:
               CH-.
               CH,
N-N = O
     Chemical Properties

       Molecular Weight:     74.08

       Vapor Pressure:

       Boiling Point:  154C at 760 mm

       Density:    1.0059 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOO:

       Atmospheric Reactivity:
     Safety Hazard:
         Disaster hazarddangerous-toxic fumes
                           Physical State:    Liquid

                           Vapor Density:

                           Melting Point:

                           Solubility:   Soluble (H2O)
                                         AIII-288

-------
                                                          N-Nitrosodimethylamine
Annual U.S.
  Production:

Fraction of
  Dispersion:

Release Rate (million Ibs/yr):
                                PRODUCTION DATA
                       Consumption:

                       Fraction of Pro-
                         duction Lost:
                                  TOXICITY DATA
Acute Toxicity
     LD50
     LC50
    Dosage
    26 mg/kg
    36 mg/kg
    45 mg/kg
    40 mg/kg
    78 ppm (4 hours)
    57 ppm (4 hours)
Non-lethal Acute Effects:
     Irritant
     Gastrointestinal hemorrhage
     Liver damage
Chronic Toxicity

   U.S. Occupational Standard:
      (air) Carcinogen
   Carcinogenicity:
      TDLo
    Neoplastic effects:
      TDLo
   Mutagenicity:

   Teratogenicity:
     TDLo
   Other Chronic Effects:
 248 mg/kg (31 weeks)
  37 mg/kg
  30 mg/kg (35 weeks)
 370 mg/kg (56 weeks)
4375 Mg/kg
 202 mg/kg (23 weeks)

  30 mg/kg
  18 mg/kg
  18 mg/kg
  18 mg/kg
   7 mg/kg
    13 mg/kg
 Animal
rat
rat
rat
rat
rat
mouse
rat
rat
rat
mouse
mouse
rabbit

rat
rat
rat
rat
mouse
TLV:
mouse
   Route
oral
intraperitoneal
subcutaneous
rectal
inhalation
inhalation
oral
inhalation
rectal
oral
subcutaneous
oral

intraperitoneal
intramuscular
parenteral
intravenous
intraperitoneal
unknown
                                      AIII-289

-------
Nitrosoethylurea
                                     CHEMICAL NAME
    CAS Number:     759-73-9

    Chemical Name:     N-Ethyl-N-nitrosourea

    Synonyms:    l-Ethyl,l-nitrosourea
    Molecular
      Formula:    C3H7N3O2
Structure:
                   H       O       CH2CH3
                    \      n      /
                      N  - C - N
                                 \
                   H
                                   N  =  O
     Chemical Properties

       Molecular Weight:   117.13

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:

       Atmospheric Reactivity:
     Safety Hazard:
           Fire-moderate
                                               Physical State:   Solid

                                               Vapor Density:

                                               Melting Point:

                                               Solubility:
                                          AIII-290

-------
                                                                     Nitrosoethylurea
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                     Consumption:

                     Fraction of Pro-
                      duction Lost:
                                  TOXICITY DATA
Acute Toxicity
       LDSO
Non-lethal Acute Effects:
       Dermatitis
 Dosage
300 mg/kg
240 mg/kg
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
       TDLo
    Neoplasm
       TDLo

   Mutagenicity:

   Teratogenicity:
  10 mg/kg
   5 mg/kg
  20 mg/kg
2200 mg/kg (9 weeks)

  60 mg/kg
   Other Chronic Effects:
Animal
rat
rat
                             5 mg/kg (15 days
                                    pregnant)
                            29 mg/kg (12-19 days
                                    pregnant)
                            80 mg/kg (15 days
                                    pregnant)
                           240 mg/kg (22-23 days
                                    pregnant)
rat
rat
rat
mouse

mouse
                     TLV:
                      rat
                      rat
                      pig
 Route
oral
intravenous
oral
subcutaneous
intravenous
subcutaneous

intraperitoneal
                    intravenous

                    intraperitoneal

                    parenteral

                    intravenous
                                      All1-291

-------
Nitrosomethylurea
                                    CHEMICAL  NAME
    CAS Number:   684-93-5

    Chemical Name:   N-Methyl-N-nitrosourea

    Synonyms:  l-Methyl,l-nitrosourea
    Molecular
     Formula:
                    H      CH-
                	I       I
    Structure:     H - N~- C - N - N = 6
                        II
                        6



    Chemical Properties

       Molecular Weight:     103.08

       Vapor Pressure:

       Boiling Point:

       Density:

       Octanol/Water Parti-
        tion Coefficient:     -0.16

    Environmental Persistence

       BOO:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:  Solid

Vapor Density:

Melting Point:   123tol24C (decomposes)

Solubility:   Insoluble (H2O)
                                          All1-292

-------
                                                                 Nitrosomethylurea
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                               PRODUCTION DATA
                      Consumption:

                      Fraction of Pro-
                       duction Lost:
Acute Toxicity
      LDSO
         TOXICITY DATA

                       Animal
180 mg/kg             rat
110 mg/kg             rat
144 mg/kg             mouse
115 mg/kg             hamster
Chronic Toxicity

   U.S. Occupational Standard:
   Carcinogenicity:
      TDLO
   Mutagenicity:

   Teratogenicity:
      TDLO


   Other Chronic Effects:
230 mg/kg (24 weeks)
180 mg/kg (36 weeks)
 90 mg/kg
202 mg/kg (30 weeks)
 70 mg/kg
 50 mg/kg
 10 mg/kg (13 days)
 12 mg/kg (15-23 days)
rat
rat
rat
rat
rat
mouse
TLV:
rat
pregnant rat
                     Route
                   oral
                   intraperitoneal
                   intraperitoneal
                   subcutaneous
intiaperitoneal
subcutaneous
oral
skin
intravenous
intraperitoneal
intraperitoneal
intravenous
                                      AIII-293

-------
m-Nitrotoluene
                                    CHEMICAL  NAME
    CAS Number:   99-08-1

    Chemical Name:    m-Nitrotoluene

    Synonyms:   3-Methylnitrobenzene
    Molecular
     Formula:   C7H7NO2
                   CH,
    Structure:
                        NO,
    Chemical Properties

       Molecular Weight:   137.14

       Vapor Pressure:  1 mm at 50C

       Boiling Point:   232.6Cat 760mm

       Density:      1.1571 at 20C/4C

       Octanol/Water Parti-
        tion Coefficient:   2.45

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
          Fire-moderate
Physical State:  Liquid

Vapor Density:  4.72

Melting Point:   16C

Solubility:   Insoluble (H2O)
                                         AIII-294

-------
                                                                   m-Nitrotoluene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                    Consumption:

                    Fraction of Pro-
                      duction Lost:
                                TOXICITY DATA
Acute Toxicity
      LDSO
 Dosage
1072 mg/kg
 330 mg/kg
2400 mg/kg
3600 mg/kg
Animal
rat
mouse
rabbit
guinea pig
  Route
oral
oral
oral
oral
Chronic Toxicity

   U.S. Occupational Standard:  (air) TWA 5 ppm


   Carcinogen icity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                    TLV:
                                    AIII-295

-------
o-Nitrotoluene
                                     CHEMICAL  NAME
    CAS Number:    88-72-7

    Chemical Name:     o-Nitrotoluene

    Synonyms:   2-Methylnitrobenzene
                2-Nitrotoluene

    Molecular
      Formula:   C7H7NO2
    Structure:
    Chemical Properties

       Molecular Weight:      137.14

       Vapor Pressure:  1 mm at 50C

       Boiling Point:    220.4C at 760 mm

       Density:  1-1629 at 20C

       Octanol/Water Parti-
         tion Coefficient:   2.30

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
           Fire-moderate
Physical State:   Liquid

Vapor Density:   4.72

Melting Point:   -9.55C

Solubility:   Insoluble (H2O)
                                          AIII-296

-------
                                                                   o-Nitrotoluene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                             PRODUCTION DATA
                    Consumption:

                    Fraction of Pro-
                     duction Lost:
                               TOXICITY DATA
Acute Toxicity
      LDSO
  Dosage
 891 mg/kg
2462mg/kg
Animal
rat
Chronic Toxicity

   U.S. Occupational Standard:  (aii) TWA 5 ppm



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:

   Other Chronic Effects:
                    TLV:
  Route
oral
oial
                                    AIII-297

-------
p-Nitrotoluene
                                     CHEMICAL  NAME
    CAS Number:    99-99-0

    Chemical Name:     p-Nitrotoluene

    Synonyms:*   4-Methylnitiobenzene
    Molecular
      Formula:   C7H7NO2
    Structure:
                 NO-,
    Chemical Properties

       Molecular Weight:    137.14

       Vapor Pressure:  1 mm at 53.7C

       Boiling Point: 238.3C at 760mm

       Density:  1.1038 at 75C/4C

       Octanol/Water Parti-
        tion Coefficient:   2.42

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
    Safety Hazard:
Physical State:   Solid

Vapor Density:   4.72

Melting Point:    54.5C

Solubility:    Insoluble (H2O)
                                          AIII-298

-------
                                                                     p-Nitrotoluene
Annual U.S.
 Production:

Fraction of
 Dispersion:

Release Rate (million Ibs/yr):
                              PRODUCTION DATA
                    Consumption:

                    Fraction of Pro-
                     duction Lost:
                                TOXICITY DATA
Acute Toxicity
      LDSO
 Dosage
2144 mg/kg
1231 mg/kg
 940 mg/kg
Animal
rat
mouse
mammal
(unspecified)
 Route
oial
oral
intrapeiitoneal
Chronic Toxicity

   U.S. Occupational Standard: (air) TWA 5 ppm



   Carcinogenicity:


   Mutagsnicity:

   Teratogenicity:

   Other Chronic Effects:
                    TLV:  5 ppm (skin)
                                    AIII-299

-------
Nonene
                                     CHEMICAL  NAME
    CAS Number:   27215-95-8

    Chemical Name:    Nonene

    Synonyms:  Nonene (mixed isomers)
               Nonylene

    Molecular
      Formula:  C9H18
    Structure:    CH3 - (CH2)6 - CH = CH2
(1 - Nonene)
    Chemical Properties

       Molecular Weight:     126.19

       Vapor Pressure:

       Boiling Point:   149.9C (1-nonene)

       Density:    0.7433 (1-nonene)

       Octanol/Water Parti-
         tion Coefficient:

    Environmental Persistence

       BOD:

       Atmospheric Reactivity:
      Physical State:     Liquid

      Vapor Density:

      Melting Point:

      Solubility:     Insoluble (H2O)
     Safety Hazard:
          Firecombustible
                                          AIII-300

-------
                                                                             Nonene

                             PRODUCTION DATA
Annual U.S.
 Production:                                  Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:

Release Rate (million Ibs/yr):
                                TOXICITY DATA

Acute Toxicity               Dosage              Animal              Route
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                              TLV:

   Other Chronic Effects:
                                    AIII-301

-------
Nonyl  phenol
     CAS Number:    25154-52-3

     Chemical Name:     Nonylphenol

     Synonyms:    p-Nonylphenol
                 Hydroxyl No. 253

     Molecular
      Formula:    C15H24O
                                     CHEMICAL NAME
    Structure:
                  HO
C9H19
     Chemical Properties

       Molecular Weight:   220.34

       Vapor Pressure:   10 mm at 25C

       Boiling Point:     290 to 302C

       Density:   0.949 at 20C/4C

       Octanol/Water Parti-
         tion Coefficient:

     Environmental Persistence

       BOD:,

       Atmospheric Reactivity:
           Rapidly biodegraded
           Not reactive to 63 or ROj
           Reacts with oxidizing materials
           tw OH = 2 days

     Safety Hazard:
           Fire-slight
                   Physical State:   Liquid

                   Vapor Density:   7.59

                   Melting Point:

                   Solubility:   Insoluble (H2O)
                                           AIII-302

-------
                                                                      Nonyl  phenol
                              PRODUCTION DATA

Annual U.S.
 Production:     191 x 106 Ibs. (1976 capacity)       Consumption:

Fraction of                                    Fraction of Pro-
 Dispersion:                                    duction Lost:  0.007

Release Rate (million Ibs/yr):  180.6 (ethoxylated compound)
                                TOXICITY DATA

Acute Toxicity              Dosage               Animal              Route
       LD50              1620mg/kg            rat                oral
                         2140 mg/kg            rabbit              skin
Chronic Toxicity

   U.S. Occupational Standard:



   Carcinogenicity:


   Mutagenicity:

   Teratogenicity:                               TLV:

   Other Chronic Effects:
                                    AIII-303

-------
                                   TECHNICAL REPORT DATA
                            (Please read Inunctions on the reverse before completing)
1. REPORT NO.
  EPA-450/3-77-008d
                              2.
                                                            3. RECIPIENT'S ACCESSION NO.
4.TiTLVMjTfMfffa(^ scoring  of Organic Air  Pollutants:
     Chemistry, Production and Toxicity of
     Synthetic Organic  Chemicals
     (Chemicals F-N) Appendix III 	
                                                            5. REPORT DATE
                                                                   October  1976
                                                            6. PERFORMING ORGANIZATION CODE
7. AUTHOR(S)
                                                            8. PERFORMING ORGANIZATION REPORT NO.
     J.  Dorigan, B.  Fuller, R. Duffy
9. PERFORMING ORGANIZATION NAME AND ADDRESS
     The Mitre  Corporation
     Metrek Division
     Westgate Research Park
     McLean, Virginia  22101
                                                            10. PROGRAM ELEMENT NO.
                                                            11. CONTRACT/GRANT NO.
                                                               68-02-1495
12. SPONS
     NSORING AGENCY NAME AND ADDRES
     EPA, Office  of Air Quality Planning
          Office of    r
     Strategies and  Air Standards
     Research Triangle Park, N.C.
       and
Division
 27711
Standards
                                                            13. TYPE OF REPORT AND PERIOD COVERED
                                                            14. SPONSORING AGENCY CODE
15. SUPPLEMENTARY NOTES
16. ABSTRACT
          This  is  the third of a  series of four  appendices to  the  report "Scoring
     of Organic Air Pollutants."   The entire appendix contains  a compilation of
     available  data on chemical structure and  properties, environmental persistence,
     production,  and toxicity  for 637 synthetic  organic chemicals.
17.
                                KEY WORDS AND DOCUMENT ANALYSIS
                  DESCRIPTORS
                                               b.lDENTIFIERS/OPEN ENDED TERMS  C. COS ATI Field/Group
     organic  chemical
     organic  chemical
     organic  chemical
     organic  chemical
                       structure
                       properties
                       production
                       toxicity
18. DISTRIBUTION STATEMENT
     unlimited
                                               19. SECURITY CLASS (This Report)
                                                  unclassified
                                                                          21. NO. OF PAGES
                                                                              310
                                               20. SECURITY CLASS (This page)
                                                  unclassified
                                                                          22. PRICE
EPA Form 2220-1 (9-73)

-------