SEPA
United States
Environmental Protection Agency
Washington DC 20460
December 1985
IflSORJUIIOJl
Chemical Emergency
Preparedness Program
Interim Guidance
• Chemical Profiles
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NOTICE
This document has been reviewed in accordance with the U.S. Environmental
Protection Agency's peer and administrative review policies and approved for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
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The following comments are specific to various sections of the profile
'•f ormat:
• Chemical Identity -- The name stated is the name
used on the list of acutely toxic chemicals and is one
of the most used common names.
• CAS Registry Number -- The number is identical to
the number listed in RTECS associated with the toxicity
data used to identify the chemical for the list.
• Synonyms -- Synonyms from TDB/HSDB files are listed
without citation. Synonyms from NIOSH/RTECS (1983) or
SANSS (1983), or other sources are referenced. The 9th
Collective Index (CI) name from the SANSS 1983 database
was added to each profile when the 9th CI name was
different from the 8th CI name.
• Chemical Formula and Molecular Weight -- Data from
TDB/HSDB or NIOSH/RTECS (1983) are not cited. Formulas
or molecular weights found in other sources are cited.
• Section I -- Hazardous Ingredients/Identity
Information -- Wherever possible, specific exposure
limits are given for each chemical, as cited by the
sources. Data found for recommended occupational
standards or for categories of chemicals are provided
under the heading "Other Limits Recommended." If no
value for the category Immediately Dangerous to Life and
Health (IDLH) is available for the chemical, the
toxicity information needed to calculate a "level of
concern," as described in Appendix D of the Chemical
Emergency Preparedness Program guidance document, is
provided under "Other Limits Recommended". Toxicity
values used as the basis for listing the chemical are
provided if the IDLH calculation values are not as toxic
as the listing values. These toxicity data were
obtained from a screen of the NIOSH/RTECS on-line
computer file and are also cited with an asterisk (*)
(e.g., '^NIOSH/RTECS 1985). In addition, human
carcinogens or suspect carcinogens listed by the
American Council of Government Industrial Hygienists
(ACGIH) are indicated in this section. Other citations
regarding carcinogens may be found in Section V.
• Section II -- Physical/Chemical Characteristics --
Boiling points and melting points are provided in both
degrees Fahrenheit and degrees Centigrade. Conversions
by EPA were performed as needed.
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• Section III -- Fire and Explosion Hazard Data -- In
the absence of chemical-specific information, generic
information is provided whenever the chemical could be
categorized.
• Section IV -- Reactivity Data --In the absence of
chemical-specific information, generic information is
provided whenever the chemical could be categorized.
• Section V -- Health Hazard Data -- Generally, only
human data are reported in the Health Hazard Data
section. Information on the route of exposure, health
hazards, and signs and symptoms were often not available
or only partially available for specific chemicals.
Health hazard data and signs and symptoms often were not
found specific to dose, route of entry or exposure type
(acute, delayed, or chronic). The emergency and first
aid procedures are intended for a non-medical
personnel. No information on invasive medical
procedures are provided. Generic information on the
chemical category was provided, wherever possible, in
the absence of information on the specific chemical.
• Section VI -- Use Information -- The EPA status of
a pesticide is provided if the status would limit the
use.
• Section VII -- Precautions for Safe Handling and
Use -- Chemical-specific information often was not
found in this section. Generic information for the
chemical category often is presented.
• Comments -- This section is provided, in some
cases, to document the lack of data available for a
specific chemical by denoting the sources that were
checked for information. In general, this section
pertains to chemicals without TDB/HSDB files.
The following comments are specific to various entries on the profiles:
• Not Found -- This statement on the profile can mean
that:
-- the value or information was not found in the
references used,
the value or information probably does not exist for
this chemical, or
the value is meaningless or not applicable for this
chemical.
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• Suspect -- This statement following the value or
information on the profile means that the information is
correctly copied from the cited reference but is
suspected to be in error based on deductions made by a
critical examination of all data presented on the
profile.
The following comments are specific to certain profiles:
Chemical CAS Number Comment on Suspect Items
65-86-1 The LDrn oral (mouse) is unexpectedly low in
comparison to the intraperitoneal (mouse) LD-n
of 600 mg for the 1:1 compound with 5 (or 4)-
aminoimidazole-4-carboxamide.
75-18-3 The LC inhalation (rat) is reported as 40250
ppm -- roughly 1000X the LC inhalation
(mouse).
75-74-1 Ideal gas law calculations predict a higher vapor
density.
78-00-2 Ideal gas law calculations predict a higher vapor
density.
97-18-7 LD oral (mouse) is 900 mg/kg; also classified
as "slightly toxic" in Health Hazard section.
106-96-7 Ideal gas law calculations predict a lower vapor
density.
108-67-8 1980 RTECS reports an LC inhalation (rat) of
2240 ppm. This is consistent with a TWA of 25
ppm but not with the LC,.. of 24 mg/m3.
109-19-3 1978 and 1980 RTECS report an LD5Q of 8.2 g/kg;
1983 and 1985 RTECS report 8,200 ug/kg. The
latter value is anomalously low for compounds of
this class.
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EPA CHEMICAL PROFILES
TABLE OF CONTENTS
INTRODUCTION AND COMMENT 11-6
ABBREVIATIONS Al-2
GLOSSARY Gl-9
REFERENCES Rl-19
PROFILES BY CAS NUMBER*
* Chemical Abstracts Service Registry Number.
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Chemical CAS Number
Comment on Suspect Items
117-84-0
128-56-3
RTECS 1985 value for LC inhalation (mouse) is
anomalously low. RTECS also uses the same CAS
number for both di-n-octyl phthalate and di-2-
ethylhexyl phthalate, thus rendering doubtful
which effects should be associated with which
chemical. Ideal gas law calculations predict a
different vapor density.
ID oral (rabbit) of 14 mg/kg appears low by
comparison with that for the 2-substituted
sulfonate.
129-00-0
Reported boiling point is anomalously higher for
compounds of this class.
131-11-3
149-74-6
Low volatility renders improbable a concentration
of pyrene in air as high as 170 mg/m3 except as
a dust. Therefore, the inhalation toxicity
values are suspect.
Widely differing values of IDLH as well as other
RTECS data render this suspect.
Flash point of 28°C is not consistent with
boiling point of 205°C.
287-92-3
Note conflict between 1983 and 1985 RTECS LC
data.
low
624-92-0
625-55-8
646-06-0
LC inhalation (mouse) very much lower than
LCSf. inhalation (rat).
Other formate esters are about 1000X less toxic
than isopropyl formate is reported to be.
LC1 inhalation (rat) is 96.6 mg/L; LC,.-
inhalation (mouse) is 104 vg/m3 or 0.0001
mg/L; million-fold difference suggests a
conversion error.
1331-17-5
100-fold difference in LD,. between rat and
mouse is suspect.
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Chemical CAS Number Comment on Suspect Items
1335-87-1 Widely different melting points reported for this
compound in references.
2238-07-5 Ideal gas law calculations predict a higher vapor
density.
2244-16-8 • ID oral (rat) value is roughly 1000-fold
lower than carvone of unspecified absolute
configuration.
5281-13-0 Farm Chemicals Handbook (1984), p. C-236, reports
the LD oral (rat) as above 4400 mg/kg.
7637-07-2 Values of boiling point in references vary
widely, and none of these are in agreement with
reported vapor pressure.
10049-07-7 Boiling point given as "800°C, sublimes" is
inconsistent with a melting point with
decomposition of 450-500°C.
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EPA CHEMICAL PROFILES
ABBREVIATIONS
ACGIH -- American Conference of Government and Industrial Hygienists
ADI -- Acceptable Daily Intake
AIHA -- American Industrial Health Association
BAL -- Dimercaprol (British anti-lewisite)
CAS -- Chemical Abstracts Service
CC -- Closed cup
CNS -- Central Nervous System
EEC -- Electroencephalogram
EKG -- Electrocardiogram
EPA -- Environmental Protection Agency
IARC -- International Agency for Research on Cancer
IDLH -- Immediately Dangerous to Life and Health
im -- intramuscularly
LCLO -- Lethal Concentration Low; the lowest concentration at which death
occurred
LC50 -- Lethal Concentration 50; the concentration at which 50% of the
animals died; a calculated value
LDLO -- Lethal Dose Low; the lowest dose at which death occurred
LD50 -- Lethal Dose 50; the dose at which 50% of the animals died; a
calculated value
LEL -- Lower Explosive Limit
m3 -- Cubic meter
mg/Kg -- milligrams per kilogram
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ABBREVIATIONS
(Continued)
mmHg -- millimeters of Mercury; a measure of pressure
NIOSH -- National Institute of Occupational Safety and Health
n.o.s. -- Not otherwise specified
NRC -- National Research Council, National Academy of Sciences
NTP -- National Toxicology Program
OC -- open cup
OSHA -- Occupational Safety and Health Administration
PEL -- Permissible Exposure Level
ppb -- parts per billion
ppm -- parts per million
RBC -- Red blood cell(s)
RTECS -- Registry of Toxic Effects of Chemical Substances
STEL -- Short-term exposure limit
TCC -- Tagliabue Closed Cup, a standard method of determining flash point
TOC -- Tagliabue Open Cup, a standard method of determining flash point
TDLO -- Toxic Dose Low; the lowest dose at which toxicity occurred
TLV -- Threshold Limit Value
TWA -- Time Weighted Average
DEL -- Upper Explosive Limit
pg -- microgram
2-PAM -- pralidoxime
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EPA CHEMICAL PROFILES
GLOSSARY
Acaricide --an agent that destroys mites
Acidosis -- pathologic condition resulting from accumulation of acid in, or
loss of base from, the blood or body tissues
Acneform -- resembling acne
Albuminuria -- presence of serum albumin in the urine
Alopecia -- baldness; absence of hair from skin areas where it is ususally
present
Amorphous -- without definite form, not crystallized
Anaphylactoid -- resembling an unusual or exaggerated allergic reaction to
foreign protein or other substances
Anorexia -- lack or loss of appetite for food
Anoxia -- absence or lack of oxygen; reduction of oxygen in the body
tissues below physiologic levels
Anthelmintic -- an agent that is destructive to worms especially of the
intestine
Anticoagulant --an agent that prevents blood clotting
Antilewisite -- dimercaprol; also called British anti-lewisite, or BAL
Antimetabolite -- a substance that interferes with utilization of an
essential metabolite
Antipyretic -- an agent that relieves or reduces fever
Aphasia -- defect or loss of power of expression by or comprehension of
speech, writing, or signs
Aplasia -- lack of development of an organ or tissue, or the cellular
products from an organ or tissue; germinal aplasia -- complete failure of
gonad development
Argyrosis -- poisoning by silver or a silver salt, evidenced by ashen-gray
discoloration of skin
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GLOSSARY
(Continued)
Arrhythmia -- any variation from the normal rhythm of the heart beat
Arteriosclerosis -- hardening and thickening of the walls of the smaller
arteries
Asthenia -- lack or loss of strength; weakness
Astringent -- causing contraction, usually locally after surface application
Ataxia -- failure of muscular coordination; irregularity of muscular action
Avicide -- an agent that kills birds
Bioaccumulation -- increased concentrations of a chemical in an organism
compared to the surrounding environment
Bradycardia -- slowness of the heart beat, as evidenced by slowing of pulse
rate to less than 60
Bronchoconstriction -- narrowing of the air passages of the lungs
Calcification -- process by which organic tissue becomes hardened by a
deposit of calcium salts within its substance
Carcinogenic -- producing or inciting cancer
Cardiac -- pertaining to the heart
Cathartic -- causing evacuation of the bowels; laxative
Cheyne-Stokes respiration -- respiratory distress related to posture
(especially reclining at night) that occurs in association with heart disease
Chloracne -- acne-like eruption caused by exposure to chlorine compounds
Clonic -- pertaining to alternate muscular contraction and relaxation in
rapid succession
Conjunctivitis -- inflammation of the lining of the eyelids
Contraindication -- any condition which renders some particular line of
treatment improper or undesirable
Cryogenic -- pertaining to or causing the production of low temperatures
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GLOSSARY
(Continued)
Cyanosis -- bluish discoloration, especially of the skin and mucous
membranes and fingernail beds
Decoction -- substance prepared by boiling
Demulcent -- soothing
Dermal -- pertaining to the skin
Dermatitis -- inflammation of the skin
Desiccant --a drying agent
Diluent -- a diluting agent
Diuresis -- increased secretion of urine
Diuretic -- agent that increases urine production
DS2 -- standard decontaminant for chemical agents; highly corrosive and
highly toxic
Ductile -- capable of being drawn out or hammered thin
Dyspnea -- difficult or labored breathing
Ectoparasiticide -- an agent that kills parasites living on the exterior of
its host
Edema -- presence of abnormally large amounts of fluid in intercelluar
spaces of body tissues
Emesis -- vomiting
Enteritis -- inflammation of the intestine
Epigastric -- pertaining to the upper-middle region of the abdomen
Epileptiform -- occurring in severe or sudden spasms
Epithelium -- cells covering the internal and external surfaces of the body
Erythema -- redness of the skin produced by congestion of the capillaries
Exothermic -- characterized by or formed with evolution of heat
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GLOSSARY
(Continued)
Explosive -- characterized by or relating to bursting forth with sudden
violence or noise from internal energy; relating to a rapid reaction with
production of noise, heat, and violent expansion of gases
Flammable -- capable of being easily ignited and supporting combustion
Gastrointestinal -- pertaining to the stomach and intestine
o '
Germinalaplasia -- lack of development of egg and sperm cells
Glomerular -- pertaining to a tuft or cluster, as of blood vessels or nerve
fibers
Half-life -- the time in which the concentration of a substance will be
reduced by half
Halon -- halogenated hydrocarbon (e.g., carbon tetrachloride)
Health Hazard --
Acute -- immediate toxic effects
Chronic -- persistent or prolonged injury
Delayed -- toxic effect occurring after a lapse of time
Hematoma -- localized collection of blood, usually clotted, in an organ,
space, or tissue, due to a break in the wall of the blood vessel
Hematuria -- blood in the urine
Hemoglobinuria -- presence of free hemoglobin in the urine
Hemolysis -- separation of hemoglobin from red blood cells and its
appearance in the plasma
Hemolytic -- pertaining to or characterized by hemolysis
Hepatic -- pertaining to the liver
Humectant -- moistening or diluent substance
Hydrolysis -- double decomposition reaction involving the splitting of
water into its ions and the formation of a weak acid and/or a weak base
Hygroscopic -- readily taking up and retaining moisture (water)
Hyperactivity -- abnormally increased activity
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GLOSSARY
(Continued)
Hyperalimentation -- ingestion or administration of a greater than optimal
amount of nutrients
Hyperbilirubinemia -- an excess of bilirubin in the blood
Hypercalcemia -- excess of calcium in the blood
Hyperparathyroidism -- abnormally increased activity of the parathyroid
glands which affects and is affected by serum calcium levels
Hyperpyrexia -- a highly elevated body temperature
Hyperreflexia -- exaggeration of reflexes
Hypersalivation -- excessive secretion of saliva
Hypertension -- persistently high arterial blood pressure
Hypervitaminosis -- condition due to ingestion of an excess of one or more
vitamins
Hypobilirubinemia -- abnormally low levels of bilirubin in the blood
Hypocalcemia -- abnormal reduction of blood calcium levels
Hypovolemic -- pertaining to an abnormally decreased volume of circulating
fluid (plasma) in the body
Hypoxemia -- deficient oxygenation of the blood
Hypoxia -- low oxygen content or tension; deficiency of oxygen in the
inspired air
Interstitial Pneumonia --a chronic form of pneumonia with increase of the
interstitial tissue and decrease of the proper lung tissue
Isotonic -- a solution having the same effective osmotic pressure as the
body fluid to which it is compared
Jaundice -- syndrome characterized by hyperbilirubinemia and deposition of
bile pigment in the skin, resulting in yellow appearance of the patient
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GLOSSARY
(Continued)
Lachrymator (or lacrimator) -- a substance which increases the flow of tears
Lacrimation -- secretion and discharge of tears
Laryngospasm -- spasmodic closure of the larynx
Larynx -- the muscular and cartilage structure situated at the top of the
trachea (windpipe) and below the root of the tongue, functioning as sphincter
into the trachea and as the organ of voice
Lassitude -- weakness; exhaustion
Latency -- a state of seeming inactivity
Lesion -- a pathological or traumatic discontinuity of tissue or loss of
function of a part
Lethal -- deadly; fatal
Leukopenia -- reduction in the number of leukocytes in the blood
Lewisite --a lethal war gas which is a vesicant, lacrimator and lung
irritant
Malaise -- a vague feeling of bodily discomfort
Mania -- a phase of mental disorder characterized by an expansive emotional
state, elation, overtalkativeness, and increased motor activity
Metastatic -- pertaining to the transfer of disease from one organ or part
to another not directly connected with it
Methemoglobinemia -- presence of methemoglobin (oxidized hemoglobin) in the
blood
Miosis (or myosis) -- contraction of the pupil
Miscible -- capable of mixing in any ratio without separation of two phases
Mordant --a chemical that fixes a dye in or on a substance by combining
with the dye to form an insoluble compound
Mutagenic -- inducing genetic mutation
Mydriasis -- extreme dilation of the pupil
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GLOSSARY
(Continued)
Myelosuppression -- suppression of the formation of bone marrow.
Narcotic -- an agent that produces insensibility or stupor
Necrosis -- death of tissue, usually as individual cells, group of cells,
or in localized areas
Nephritis -- inflammation of the kidney
Neural -- pertaining to a nerve or to the nerves
Neuropathy -- functional disturbances and/or pathological changes in the
peripheral nervous system
Neurotoxicity -- exerting a destructive or poisonous effect on nerve tissue
Nocturia -- excessive urination at night
Ocular -- pertaining to or affecting the eye
Oliguria -- secretion of a diminished amount of urine in relation to fluid
intake
Ophthalmic -- pertaining to the eye
Osteosclerosis -- hardening or abnormal density of bone
Palpitation -- unduly rapid heart beat which is noted by the patient; it
may be regular or irregular
Parasympathomimetic -- producing effects resembling time of stimulation of
the parasympathetic nerve supply to a part; called also cholinergic
Parenteral -- not through the alimentary canal but rather by injection
through some other route, such as subcutaneous, intramuscular, intravenous,
etc.
Paresthesia --an abnormal sensation, as burning or prickling
Perfusion -- liquid poured over or through an organ or tissue
Pharynx -- the muscular membrane sac between the mouth and nostrils and the
esophagus
Photophobia -- abnormal visual intolerance of light
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GLOSSARY
(Continued)
Photosensitize -- to induce a state of abnormal responsiveness to the
influence of light
Phytotoxic -- poisonous to plants; inhibiting plant growth
Polydipsia -- excessive thirst persisting for long periods of time
Precordial -- pertaining to the region over the heart and lower part of the
thorax
Proteinuria -- an excess of serum proteins in the urine; also called
albuminuria
Psychosis -- any major mental disorder characterized by derangement of the
personality and loss of contact with reality
Psychotropic -- exerting an effect upon the mind; capable of modifying
mental activity
Pulmonary -- pertaining to the lungs
Rales -- abnormal respiratory sound heard when listening for sounds within
the body
Recumbent -- lying down
Renal -- pertaining to the kidney
Scotoma -- an area of depressed vision within the visual field, surrounded
by an area of less depressed or normal vision
Supertropical Bleach -- bleaching agent containing calcium hypochlorite (a
powerful oxidizer) and calcium oxide (a corrosive material)
Systemic -- pertaining to or affecting the body or organism as a whole
Tachycardia -- excessively rapid heart beat
Tepid -- moderately warm; lukewarm
Teratogenic -- tending to produce anomalies of formation or development
Tetanic -- pertaining to or of the nature of tetanus, a disease
characterized by muscle spasm
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G-9
GLOSSARY
(Continued)
Thrombocytopenia -- decrease in the number of blood platelets
Tidal volume -- amount of gas that is inhaled and exhaled during one
respiratory cycle
Tinnitus -- a noise in the ears, such as ringing, buzzing, roaring, clicking
Toxic -- pertaining to, due to, or of the nature of a poison
Triglyceridemia -- excess of triglycerides in the blood
Urticaria -- a vascular reaction of the skin marked by the transient
appearance of smooth, slightly elevated patches (wheals) which are redder or
paler than the surrounding skin and often attended by severe itching
Vasodilation -- dilation (expansion) of a vessel, especially of arterioles
leading to increased blood flow to a part
Ventricular fibrillation -- irregular heart beat characterized by
uncoordinated contractions of the ventricle
Vertigo -- dizziness; an illusion of movement as if the external world were
revolving around an individual or as if the individual were revolving in space
Vesicant -- causing blisters
Volatile -- readily vaporizable at a relatively low temperature
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EPA CHEMICAL PROFILES
REFERENCES
* Cited in TDB/HSDB file
*/- Cited in TDB/HSDB file and as a primary source
/- Cited as a primary source
/- ACGIH. 1985. American Conference of Governmental Industrial Hygienists.
TLV threshold limit values for chemical substances and physical agents in
the work environment and biological exposure indices with intended changes
for 1985-86. Cincinnati, Ohio: ACGIH.
"/- ACGIH. 1984. American Conference of Governmental Industrial Hygienists.
TLV threshold limit values for chemical substances and physical agents in
the work environment and biological exposure indices with intended changes
for 1984-85. Cincinnati, Ohio: ACGIH.
*/- ACGIH. 1983. American Conference of Governmental Industrial Hygienists.
TLV threshold limit values for chemical substances and physical agents in
the work environment with intended changes for 1983-1984. Cincinnati,
Ohio: ACGIH.
" ACGIH. 1982. American Conference of Governmental Industrial Hygienists.
TLV threshold limit values for chemical substances and physical agents in
the work environment with intended changes for 1982. Cincinnati, Ohio:
ACGIH.
* ACGIH. 1981. American Conference of Governmental Industrial Hygienists.
TLV threshold limit values for chemical substances in workroom air adopted
by ACGIH for 1981. Cincinnati, Ohio: ACGIH.
*/- ACGIH. 1980a. American Conference of Governmental Industrial Hygienists,
Inc. Documentation of the threshold limit values, 4th ed., 1980.
Cincinnati, Ohio: ACGIH.
* ACGIH. 1980b. American Conference of Governmental Industrial
Hygienists. TLVs threshold limit values for chemical substances in
workroom air adopted by ACGIH for 1980. Cincinnati, Ohio: ACGIH.
* ACGIH. 1979. American Conference of Governmental Industrial Hygienists.
TLVs threshold limit values for chemical substances in workroom air
adopted by ACGIH for 1979. Cincinnati, Ohio: ACGIH.
* ACGIH. 1971-1979. American Conference of Governmental Industrial
Hygienists. Documentation of the threshold limit values for substances in
workroom air. Third edition, 1971. Cincinnati, Ohio: ACGIH. (Including
supplements to 1979.)
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R-2
REFERENCES
(Continued)
* Agrochem Dept. Info. Service. 1971. Anthio33 insecticide, Sandoz Ltd.
Basle, AGRO DDK E-4028/DG.
* American College of Neuropsychopharmacology. 1968. Psychopharmacology:
review of progress, 1957-1967. Proceedings of the sixth annual meeting,
Puerto Rico, December 12 to December 15, 1967. Washington, D.C.: U.S.
Government Printing Office. Public Health Service Publication No. 1836.
* AHFS. 1984. American hospital formulary service. Vols. I and II.
Washington, D.C.: American Society of Hospital Pharmacists, to 1984.
* AHFS. 1985. American hospital formulary service-drug information 85.
Bethesda, MD: American Society Hospital Pharmacists. (Tentative listing)
* American Industrial Hygiene Association Journal. 1964. Vol. 25.
* AMA. 1983. American Medical Association. AMA Department of Drugs. AMA
drug evaluations. 5th edition. Chicago: American Medical Association.
* AMA. 1980. American Medical Association. AMA Department of Drugs. AMA
drug evaluations. 4th edition. Chicago: American Medical Association.
* AMA. 1977. American Medical Association. AMA Department of Drugs. AMA
drug evaluations. 3rd edition. Littleton, Massachusetts: PSG
Publishing Co., Inc.
* AMA. 1973. American Medical Association. Council on Drugs. AMA drug
Evaluations. 2nd edition. Acton, Massachusetts: Publishing Sciences
Group, Inc.
* AOAC. 1965. Association of Official Analytical Chemists. 1965-1982.
Official methods of analysis. 10th ed. and supplements; Washington,
D.C.: AOAC. New editions through 13th ed. including supplements.
* APA. 1976, 1978. American Pharmaceutical Association. Evaluations of
drug interactions. 2nd edition and supplements. Washington, D.C.: APA.
" APA. 1973, 1974. American Pharmaceutical Association. Evaluations of
drug interactions. 1st edition and supplements. Washington, D.C.: APA.
* ASHP. American Society of Hospital Pharmacists. Data supplied on
contract from American Hospital Formulary Service and other current ASHP
sources.
* Arena JM. 1974. Poisoning: toxicology, symptoms, treatments. 4th ed.
Springfield, Illinois: Charles C. Thomas.
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REFERENCES
(Continued)
*/- Arena JM. 1979. Poisoning: toxicology, symptoms, treatments. 3rd ed.
Springfield, IL: Charles C. Thomas.
* Aronson CE, ed. 1983. .Veterinary Pharmaceuticals and biologicals,
1982-1983. Edwardsville, KS: Veterinary Medical Publishing Co.
* Aronson CE, ed. 1980. Veterinary Pharmaceuticals and biologicals,
1980-1981. Media, PA: Harwal Publishing Co.
* Ash M and Ash I. 1984. Encyclopedia of industrial chemical additions.
Vol. 1. New York, NY: Chemical Publishing Co.
/- Beardsley T. 1984. Ways of death. Nature 312:581.
/- Beilstein. 1954. Beilstein's handbuch der organischen chemie, 3rd
Supplement Series. Berlin: Springer-Verlag.
* Bergmeyer HW, ed. 1974. Methods of enzymatic analysis, 2nd English ed.
New York City: Academic Press.
* Blacow NW, ed. 1972. Martindale: The extra pharmacopoeia, 26th ed.
London: The Pharmaceutical Press.
- Booth NH, McDonald LE, eds. 1982. Veterinary pharmacology and
therapeutics, 5th ed. Ames, IA: Iowa State University Press.
* Bowman BT, Saub WW. 1979. Environmental Science Health 814:625-631.
* Bretherick L. 1979. Handbook of reactive chemical hazards. 2nd ed.
Woburn, MA: Butterworth.
* Brooke LT, Call DJ, Geiger DT, Northcott CE, eds. 1984. Acute
toxicities of organic chemicals to fathead minnows (Pimephales
Promelas). Superior, WI: Center for Lake Superior Environmental
Studies, Univ. of Wisconsin -- Superior.
* Brown KW, Evans GB, Jr., Frentrup BD, eds. 1983. Hazardous waste land
treatment. Boston, MA: Butterworth Publishers.
* Browning E. 1969. Toxicity of industrial metals. 2nd ed. New York:
Appleton-Century-Crofts.
* Browning E. 1965. Toxicity and metabolism of industrial solvents. New
York: American Elsevier.
- Brzozowski. 1985. J. Med. Pract 5:89.
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REFERENCES
(Continued)
/- Buchel KH. 1983. Chemistry of pesticides. New York: John Wiley and
Sons.
" Carmichael WW, ed. 1981. Environmental science research. Vol. 20. The
water environment-algal toxins and health. New York/London: Plenum
Press.
* Casarett LJ, Doull J. 1975. Toxicology: the basic science of poisons.
New York: MacMillan Publishing Co.
* Castegnaro M, Grimmer G, Hutzinger G, et al., eds. 1983. Laboratory
decontamination and destruction of carcinogens in laboratory wastes:
some polycyclic aromatic hydrocarbons. IARC Publication No. 49. Lyon,
France: International Agency for Research on Cancer.
* Castegnaro M, Eisenbrand G, Ellen G, et al., eds. 1982. Laboratory
decontamination and destruction of carcinogens in laboratory wastes:
some N-nitrosamines. International Agency for Research on Cancer
Publication No. 43.
* Castegnaro M, Hunt DC, Sansone EB, et al., eds. 1980. Laboratory
decontamination and destruction of aflatoxins Bl, B2, Gl, G2 in
laboratory wastes. Lyon, France: International Agency for Research on
Cancer. IARC Publication No. 37.
* The Chemical Society. 1981. Foreign compound metabolism in mammals.
Vol. 6: A review of the literature published during 1978 and 1979.
London: The Royal Society of Chemistry.
" The Chemical Society. 1979. Foreign compound metabolism in mammals.
Vol. 5: A review of the literature published during 1976 and 1977.
London: The Chemical Society.
* The Chemical Society. 1977. Foreign compound metabolism in mammals.
Vol. 4: A review of the literature published during 1974 and 1975.
London: The Chemical Society.
* The Chemical Society. 1975. Foreign compound metabolism in mammals.
Vol. 3. London: The Chemical Society.
* The Chemical Society. 1972. Foreign compound metabolism in mammals.
Vol. 2: A review of the literature published between 1970 and 1971.
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/- Weiss G, ed. 1980. Hazardous chemicals data book. Park Ridge, NJ:
Noyes Data Corporation.
* Weiss, RB and FM Muggia. 1980. American Journal of Medicine 68(2) :259.
* White-Stevens R, ed. 1976a. Pesticides in the environment: Vol 3. New
York: Marcel Dekker.
* White-Stevens R, ed. 1976b. Pesticides in the environment: Vol 2. New
York: Marcel Dekker.
* White-Stevens R, ed. 1971. Pesticides in the environment: Vol 1. Part
1, Part 2. New York: Marcel Dekker.
*/- Worthing CR, Walker SB, eds. 1983. The pesticide manual -- a world
compendium. 7th ed. Lavenham, Suffolk, Great Britain: The Lavenham
Press Limited.
-------
R-19
REFERENCES
(Continued)
Worthing CR, ed. 1979. Pesticide manual. 6th ed. Worcestershire,
England: British Crop Protection Council.
Worthy W. 1985. Methyl isocyanate: the chemistry of a hazard. Chem
Eng News 63(6):27-33.
-------
CAS Registry Number: 50-00-0
Page 1 of 5
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- FORMALDEHYDE
CAS Registry Number: 50-00-0
Synonyms: BFV; FA; Fannoform; Formaldehyde solution; Formaldehyde, as
Formalin solution (DOT); Formaldehyde, gas; Formalin; Formalin 40; Formalith;
Formic Aldehyde; Formol; Fyde; Hoch; Ivalon; Karsan; Lysoform; Methanal;
Methyl Aldehyde; Methylene Glycol; Methylene Oxide; Morbicid; NCI-C02799;
Oxomethane; Oxymethylene; Superlysoform
Chemical Formula: CH 0
Molecular Weight: 30.03
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 3 ppm; Ceiling Concentration 5 ppm; Peak Concentration
10 ppm/30 minutes/8 hours (*NIOSH/RTECS 1985)
ACGIH TLV: Ceiling limit 1 ppm (1.5 mg/m3) (*ACGIH 1980); STEL
(ceiling) 2 ppm (3 mg/m3) at 8 hours (-ACGIH 1983)
IDLH: 100 ppm (NIOSH/OSHA 1978, p. 104)
Other Limits Recommended: Occupational exposure to formaldehyde
recommended standard -- air ceiling concentration 1.2 mg/m3/30 minutes
(-NIOSH/RTECS 1985). Industrial substance suspect of carcinogenic
potential for humans recommended standard 1 ppm (ACGIH 1984, p. 42)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: -3.1°F, -19.5°C at 760 mmHg (*Merck 1976); commercial
aqueous formaldehyde boils at 205°F, 96°C (Merck 1983, p. 604)
Specific Gravity (H 0=1): 1.067 (--Merck 1976); 0.815 at -20°C/4°C
for anhydrous form (Merck 1983, p. 604)
Vapor Pressure (mmHg): 10 at -88°C (-Patty 1963), for anhydrous form
Melting Point: -134°F, -92°C (*Merck 1976), for anhydrous form
-------
CAS Registry Number: 50-00-0
Page 2 of 5
FORMALDEHYDE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Density (AIR=1): 1.03 for aqueous solution; 1.075 for gas
(*Environment Canada 1982), 1.067 for gas (Merck 1983, p. 604)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very soluble in water, up to 55% (*Merck 1976)
Appearance and Odor: Gas or liquid, strong, pungent odor, clear,
water-white (Sax 1984, p. 145).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 60°C/40% solution (*Merck 1976)
Flammable Limits:
LEL: 7% (*Sax 1975)
DEL: 73% (*Sax 1975)
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray or foam. Large fires: water spray, fog or foam. Move-
container from fire area if you can do so without risk. Do not get water
inside container. Spray cooling water on containers exposed to flames
until well after fire is out. Withdraw immediately in case of rising
sound from venting safety device or any discoloration of tank due to fire
(DOT 1984, Guide 29).
Special Fire Fighting Procedures: Keep unnecessary people away; stay
upwind; keep out of low areas. Isolate for 1/2 mile in all directions if
tank car or truck is involved in fire (*DOT 1984). Wear self-contained
breathing apparatus; wear goggles if eye protection not provided. Shut
off flow of gas or liquid and keep cooling water streams on exposed tanks
or containers. Use water spray carefully in vicinity of dusts so as not
to create dust clouds (*NFPA 1978).
Unusual Fire and Explosion Hazards: Toxic vapors such as carbon
dioxide and carbon monoxide are generated during combustion (''"Environment
Canada 1982). Explosion hazard: when aqueous formaldehyde solutions are
heated above their flash points, a potential for explosion hazard exists.
High formaldehyde concentration or methanol content lowers flash point.
Reacts with nitrogen oxides at about 180°; the reaction becomes
explosive. Also reacts violently with perchloric acid-aniline, performic
acid, nitromethane, magnesium carbonate, and hydrogen peroxide (Sax 1984,
p. 1452).
-------
CAS Registry Number: 50-00-0
Page 3 of 5
FORMALDEHYDE
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes, aqueous solutions (*Lefaux 1968)
Stable: Yes, commercial formaldehyde-alcohol solutions
(*Kirk-Othmer 1978); gas is stable in absence of
water (*Health and Safety Executive Monograph 1981)
Conditions to Avoid: Oxidizing and alkaline materials (*NFPA 1978)
Incompatibility (Materials to Avoid): Reacts with peroxide, nitrogen
oxide, and performic acid causing explosions (*Environment Canada 1982).
Can react with hydrogen chloride or other inorganic chlorides to form
bis-chloromethylether (BCME), a known carcinogen (^General Electric Co.
1981, MSDS 360). Very reactive, combines readily with many substances,
40% solution is powerful reducing agent (*Merck 1976). Incompatible with
amines, azo compounds, dithiocarbamates, alkali and alkaline earth metals,
nitrides, nitro compounds, unsaturated aliphatics and sulfides, organic
peroxides, oxidizing agents, and reducing agents (*Environment Canada
• 1982).
Hazardous Decomposition or Byproducts: When heated, irritant
formaldehyde gas evolved from solution (Sax 1984, p. 1452). The main
products of decomposition are carbon monoxide and hydrogen. Metals such
as platinum, copper, chromia, and alumina also catalyze the formation of
methanol, methylformate, formic acid, carbon dioxide, and methane (*Kirk-
Othmer 1978).
Hazardous Polymerization: May Occur: Yes (^Environment Canada 1982)
May Not Occur:
Conditions to Avoid: Compound will polymerize with active organic
materials such as phenol (*General Electric Co. 1981, MSDS 360). Will
polymerize violently in the presence of caustics and nitrides;
(amines) exothermic reaction, (Azo compound) exothermic reaction
giving off nitrogen gas, (caustics) heat generation and violent
polymerization, (dithiocarbamates) formation of flammable gases and
toxic fumes, formation of carbon disulfide may result, (alkali and
alkaline earth metals) heat generation and formation of a flammable
hydrogen gas ('"Environment Canada 1982).
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Proctor and Hughes 1978,
pp. 272-273)
Skin: Yes (Environment Canada 1982)
Ingestion: Yes (*Gosselin 1976)
-------
CAS Registry Number: 50-00-0
Page 4 of 5
FORMALDEHYDE
SECTION V — HEALTH HAZARD DATA
Health Hazards (Acute, Delayed, and Chronic): The probable oral lethal
dose for humans is 0.5-5 g/kg, or between 1 ounce and 1 pint for a 150
pound person (*Gosselin 1976). Acute -- below 1 ppm, odor perceptible to
most. 2-3 ppm, mild tingling of eyes. 4-5 ppm, increased discomfort,
mild lacrimation. 10 ppm, profuse lacrimation; can be withstood only for
few minutes. 10-20 ppm, breathing difficult, cough, severe burning of
nose and throat. 50-100 ppm, acute irritation of respiratory tract, very
serious injury likely. Skin -- primary irritation from strong solutions,
gas. Delayed -- sensitization dermatitis (Proctor and Hughes 1978, pp.
272-273). Suspected carcinogen (*Kirk-Othmer 1978). Effects in women
include menstrual disorders and secondary sterility (*IARC 1972-1985).
Solutions splashed in eyes have caused injuries ranging from severe,
permanent corneal opacification and loss of vision to minor discomfort
(*Grant 1974).
Signs and Symptoms of Exposure: Irritation of eyes, nose and throat,
tearing, cough, bronchospasm, pulmonary irritation, dermatitis (Proctor
and Hughes 1978, p. 273). Severe pain, vomiting and diarrhea result from
ingestion. After absorption, formaldehyde depresses the central nervous
system and symptoms similar to alcohol intoxication (i.e., vertigo,
depression and coma) result. It can also cause a reduction in body
temperature (^Environment Canada 1982).
Medical Conditions Generally Aggravated by Exposure: In people
sensitized to formaldehyde, late asthmatic reactions may be provoked by
brief exposures at approximately 3 ppm (*Hendrick 1982).
Emergency and First Aid Procedures: Remove victim from exposure. In
case of contact with eyes or skin flush with water for at least 15 minutes
(Proctor and Hughes 1978, p. 273). If not breathing give artificial
respiration; if breathing is difficult, give oxygen. Remove and isolate
contaminated clothing. Keep victim quiet and maintain normal body
temperature ('''DOT 1984) .
SECTION VI -- USE INFORMATION
Urea and melamine resins; polyacetal resins; phenolic resins; ethylene
glycol; pentaerythritol; hexamethylenetetramine; fertilizer; dyes,
medicine (disinfectant, germicide); embalming fluids; preservative;
hardening agent; reducing agent, as in recovery of gold and silver;
corrosion inhibitor in oil wells; durable-press treatment of textile
fabrics; possible condensation to sugars and other carbohydrates for food
use (experimental); industrial sterilant; treatment of grain smut (Hawley
1977, p. 395).
-------
CAS Registry Number: 50-00-0
Page 5 of 5
FORMALDEHYDE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Shut off ignition sources; no flares, smoking or flames in hazard area.
Do not touch spilled material; stop leak if you can do so without risk.
Use water spray to reduce vapors; do not get water inside container.
Small spills: absorb with sand or other noncombustible absorbent material
and place into containers for later disposal. Large spills: dike far
ahead of spill for later disposal (DOT 1984, Guide 29). Use fluorocarbon
water spray, Cellosize, and Hycar to diminish vapors. Use sodium
carbonate, ammonium hydroxide or sodium sulfite to neutralize spill. Use
universal gel, fly/ash, universal sorbent material, or cement powder to
absorb the spill ('"Environment Canada 1982).
-------
CAS Registry Number: 50-07-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- MITOMYCIN C
CAS Registry Number: 50-07-7
Synonyms: Ametycine; Mutamycin; NSC-26980; Azirino[2',3':3,4]pyrrolo
[l,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,la,2,8,8a,8b-
hexahydro-8a-methoxy-5-methyl-,(laR-(la.alpha.,8.beta.,8a.alpha.,8b.alpha.)]-
Chemical Formula: C1CH1QN.OC
ID 104-)
Molecular Weight: 334.37
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (rat) 14
mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Above 680°F, 360°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (*Merck 1983)
Appearance and Odor: Blue-violet crystals ("Merck 1983)
-------
CAS Registry Number: 50-07-7
Page 2 of 3
MITOMYCIN C
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Toxic doses as low as
750 ug/kg have been reported in humans ("NIOSH 1979). The major toxic
effect is myelosuppression, characterized by marked leukopenia and
thrombocytopenia; this may be delayed and cumulative. Interstitial
pneumonia and glomerular damage resulting in kidney failure are unusual
but well documented complications (Gilman 1985, p. 1289).
-------
CAS Registry Number: 50-07-7
Page 3 of 3
MITOMYCIN C
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Headaches, blurred vision, confusion,
drowsiness, fatigue, diarrhea, and pain have been occasionally noted.
These do not appear to be dose related by intravenous administration.
Fever and anorexia occur in 15 percent of patients. Hair loss, sloughing
of skin, and loss of feeling occur in approximately 4 percent of
patients. Labored breathing, cough and pneumonia occur in some cases.
Renal toxicity is sometimes observed (*AMA 1977).
Medical Conditions Generally Aggravated by Exposure: Lung conditions
-- administration of mitomycin has been recognized as causing pneumonitis,
alveolitis and pulmonary fibrosis (*Weiss 1980). Kidney conditions --
administration of mitomycin can cause kidney damage (Oilman 1985, p.
1289). Kidney toxicity was observed in 1-5 percent of patients.
Depressed immune conditions (*AMA 1977).
Emergency and First Aid Procedures: Seek immediate medical care. Skin
decontamination should be thorough, with water and soap. Eye exposure can
be followed by irrigation of eyes with plain tap water (*Ruraack 1975 to
Present). (Non-Specific -- Medicines, n.o.s.) If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. Remove
and isolate contaminated clothing and shoes at the site. Keep victim
quiet and maintain normal body temperature (DOT 1984, Guide 11).
SECTION VI -- USE INFORMATION
Anti-tumor antibiotic complex (*Merck 1976). This drug is usually
injected intravenously (*AMA 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact (see Section V above).
-------
CAS Registry Number: 50-14-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ERGOCALCIFEROL
CAS Registry Number: 50-14-6
Synonyms: 9,10-Secoergosta-5,7,10(19),22-Tetraen-3-beta-ol;
9,10-Secoergosta-5,7,10(19),22-Tetraen-3-ol,(3-beta,5Z,7E,22E)-; Activated
Ergosterol; Buco-D; Calciferol; Calciferon 2; Condacaps; Condocaps; Condol;
Crtron; Crystallina; D-Arthin; D-Tracetten; Daral; Davitamon D; Davitin;
De-Rat Concentrate; Decaps; Dee-Osterol; Dee-Ron; Dee-Ronal; Dee-Roual;
Deltalin; Deratol; Detalup; Diactol; Divit Urto; Doral; Drisdol;
Ergocalciferol; Ergorone; Ergosterol Activated; Ergosterol, Irradiated;
Ertron; Fortodyl; Geltabs; Hi-Deratol; Infron; Irradiated Ergosta-5,7,22-Trien-
3-Beta-ol; Irradiated Ergosterol; Metadee; Mina D2; Mulsiferol; Mykostin;
Oleovitamin D; Oleovitamin D2; Ostelin; Radiostol; Radsterin; Shock-Ferol;
Vitamin D_
Chemical Formula: C~0H.,0
/o 4-*f
Molecular Weight: 396.63
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD. oral (dog)
4 mg/kg (--NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 239-244°F, 115-118°C ('''Merck 1976)
Vapor Density (AIR=1): Not Found
-------
CAS Registry Number: 50-14-6
Page 2 of 3
ERGOCALCIFEROL
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble in water (*Merck 1976)
Appearance and Odor: White crystals, odorless (*0sol 1975)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Medicines, n.o.s.) Extinguish
with dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984,
Guide 11).
Special Fire Fighting Procedures: (Non-Specific -- Medicines, n.o.s.)
Move container from fire area if you can do so without risk. Spray
cooling water on containers that are exposed to flames until well after
fire is out (DOT 1984, Guide 11).
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Furia 1972)
Stable:
Conditions to Avoid: Shows signs of decomposition when stored for
a few days at room temperature (*Furia 1972).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 50-14-6
Page 3 of 3
ERGOCALCIFEROL
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Ergocalciferol poisoning
disturbs calcium metabolism and causes kidney damage (Buchel 1983, p.
224). Ergocalciferol in a single acute ingestion presents no toxic
hazards. Daily ingestion in excess of 5000 units/day in children or 7500
units/day in adults will produce toxic symptoms associated with
hypervitaminosis D (*Rumack 1975 to Present).
Signs and Symptoms of Exposure: Initial symptoms of ergocalciferol
poisoning include anorexia, nausea and vomiting. It often mimics
hyperparathyroidism with thirst, muscular weakness, nervousness, kidney
impairment, hypertension (*Gosselin 1976), and excessive urination
(-Oilman 1980).
Medical Conditions Generally Aggravated by Exposure: Those with
hypercalcemia are at a greater risk (Physicians' Desk Reference 1985, p.
• 1748)
Emergency and First Aid Procedures: (Non-Specific -- Medicines,
n.o.s.) Move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature (DOT 1984, Guide 11).
SECTION VI -- USE INFORMATION
Nutrient and/or dietary supplement food additive ("Sax 1975).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Medicines, n.o.s.) Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas. Wear
self-contained (positive pressure if available) breathing apparatus and
full protective clothing. Shut off ignition sources; no flares, smoking
or flames in hazard area. Keep combustibles (wood, paper, oil, etc.) away
from spilled material. Do not touch spilled material. Small spills:
absorb with sand or other noncombustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 11).
-------
CAS Registry Number: 51-21-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- FLUOROURACIL
CAS Registry Number: 51-21-8
Synonyms: Uracil, 5-Fluoro-; 5-Fluorouracil; Efudex; Fluoroplex;
2,4-Dioxo-5-Fluoropyrimidine; 5-Fluoro-2,4(lH,3H)-Pyrimidinedione; 5-Fluoro-
2,4-Pyrimidinedione; 5-Fluoropyrimidine-2,4-Dione; 5-Fluoropyrimidine-
2,4-Dione; Fluoro Uracil; Fluracil; Fluril; FU; 5-FU; NSC 19893; RO 2-9757;
U-8953; 2,4(1H,3H)-Pyrimidinedione, 5-Fluoro-
Chemical Formula: C.H0FN00.
43 22
Molecular Weight: 130.08
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (rabbit)
18.9 mg/kg .(*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Decomposes at 540-541°F, 282-283°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g in 80 mL of water (*0sol 1975)
Appearance and Odor: White to practically white crystalline powder;
practically odorless (*0sol 1975)
-------
CAS Registry Number: 51-21-8
Page 2 of 4
FLUOROURACIL
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Drugs or Medicines, n.o.s.
(Solid) Poison B) Extinguish fire using agent suitable for type of
surrounding fire (material itself burns with difficulty). Use water in
flooding quantities as fog. Use "alcohol" foam, carbon dioxide or dry
chemical (Student 1981, p. 215).
Special Fire Fighting Procedures: (Non-Specific -- Drugs or Medicines,
n.o.s. (Solid) Poison B) Avoid breathing dusts, and fumes from burning
material. Keep upwind. Avoid bodily contact with the material. Wear
boots, protective gloves, and goggles. Wear self-contained breathing
apparatus (Student 1981, p. 215).
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*0sol 1975)
Conditions to Avoid: Decomposing heat ("Merck 1976)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Emits very toxic fumes of
flourides and nitrogen oxides when heated to decomposition (Sax 1984, p.
1450).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Yes (Physicians' Desk Reference 1980, p. 1452)
Ingestion: Yes ("Goodman 1975)
-------
CAS Registry Number: 51-21-8
Page 3 of 4
FLUOROURACIL
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Minimum toxic dose in
humans is approximately 450 mg/kg (total dose) over 30 days for the
ingested drug. Intravenous minimum toxic dose in humans is a total dose
of 6 mg/kg over three days. Depression of white blood cells occurred
after intravenous administrative of a total dose of 480 mg/kg over 32 days
0-NIOSH/RTECS 1978).
Signs and Symptoms of Exposure: Loss of appetite and nausea are
earliest symptoms, with other symptoms of diarrhea, inflammation or sores
in the mouth, gastric burning, and intestinal discomfort. More serious
symptoms are due to the suppression of bone marrow, with decrease of white
cell count and blood platelets, and anemia. Hair loss, nail changes,
dermatitis, and pigmentation and atrophy of skin also occur ("Goodman
1975).
Medical Conditions Generally Aggravated by Exposure: Occasional
neuropathy and cardiac toxicity have been reported (Gilman 1985, pp.
1270-1271). Do not use during pregnancy (Physicians' Desk Reference 1980,
p. 1455). Patients with impaired hepatic or renal function, with a
history of high-dose pelvic irradiation or previous use of alkylating
agents should be treated with extreme caution (Physicians' Desk Reference
1980, p. 1455). Patients with nutritional deficiencies and protein
depletion have a reduced tolerance to fluorouracil (Gilman 1985, p. 1270).
Emergency and First Aid Procedures: (Non-Specific -- Drugs) Move
victim to fresh air; call emergency medical care. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. In case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Remove and isolate contaminated clothing
and shoes at the site. Keep victim quiet and maintain normal body
temperature (DOT 1984, Guide 11).
SECTION VI -- USE INFORMATION
Antineoplastic drug (''"Merck 1976); chemosterilant for insects
("White-Stevens 1976).
-------
CAS Registry Number: 51-21-8
Page 4 of 4
FLUOROURACIL
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Drugs) Keep unnecessary people away; isolate hazard area
and deny entry. Stay upwind; keep out of low areas. Wear self-contained
(positive pressure if available) breathing apparatus and full protective
clothing. If water pollution occurs, notify appropriate authorities.
Spill or leak: shut off ignition sources; no flares, smoking or flames in
hazard area. Keep combustibles (wood, paper, oil etc.) away from spilled
material. Do not touch spilled material. Small spills: absorb with sand
or other noncombustible absorbent material and place into containers for
later disposal. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 11).
-------
CAS Registry Number: 51-75-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- MECHLORETHAMINE
CAS Registry Number: 51-75-2
Synonyms: 2,2'-Dichloro-N-Methyldiethylamine; 2-Chloro-N-(2-Chloroethyl)-
N-Methylethanamine; Beta.Beta1-Dichlorodiethyl-N-Methylamine; Bis(2-Chloro-
ethyl)Methylamine; Bis(Beta-Chloroethyl)Methylamine; Caryolysin; Chloramine
(the nitrogen mustard); Chlorethazine; Chlormethine; Di(2-Chloroethyl)
Methylamine; Dichlor Amine; Diethylamine, 2,2*-Dichloro-N-Methyl-; Embichin;
ENT-25294; Ethanamine, 2-Chloro-N-(2-Chloroethyl)-N-Methyl-; HN2; MBA;
MethyIbis(2-Chloroethyl)Amine; MethyIbis(Beta-Chloroethyl)Amine; Methylbis
(Chloroethylamine); Methyldi(2-Chloroethyl)Amine; Mustargen; Mustine;
N,N-Bis(2-Chloroethyl)methylamine; N,N-Di(Chloroethyl)Methylamine;
N-Methyl-2,2'-Dichlorodiethylamine; N-Methyl-bis(2-Chloroethyl)Amine;
N-Methyl-Bis(Beta-Chloroethyl)Amine; N-Methylbis(2-Chloroethyl)Amine;
N-MethyIbis(Beta-Chloroethyl)Amine; Nitrogen Mustard; NSC 762; TL 146
Chemical Formula: C H Cl N
Molecular Weight: 156.07
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC.. inhalation
(dog) 0.29 mg/liter/10 minutes (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 189°F, 87°C at 18 mmHg (*Merck 1976)
Specific Gravity (H 0=1): 1.118 at 25°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: -76°F, -60°C (*Merck 1976)
-------
CAS Registry Number: 51-75-2
Page 2 of 4
MECHLORETHAMINE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very slightly soluble (*Merck 1976)
Appearance and Odor: Mobile liquid; faint odor of herring (*Merck
1976).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Poisonous Liquid, n.o.s.)
Small fires: dry chemical, carbon dioxide, water spray, or foam. Large
fires: water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Poisonous Liquid,
n.o.s.) Stay upwind; keep out of low areas. Ventilate closed spaces
before entering them. Wear positive pressure breathing apparatus and
special protective clothing. Move container from fire area if you can do
so without risk. Fight fire from maximum distance. Dike fire control
water for later disposal; do not scatter the material (DOT 1984, Guide 55)
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (-'Merck 1976)
Stable:
Conditions to Avoid: Undiluted liquid decomposes on standing
(•-Merck 1976)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 51-75-2
Page 3 of 4
MECHLORETHAMINE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes ("Oilman 1980)
Skin: Yes ("Oilman 1980)
Ingestion: Yes (-Oilman 1980)
Health Hazards (Acute, Delayed, and Chronic): Toxic doses as low as
400 yg/kg have been reported in humans (-NIOSH/RTECS 1985). Blood clots
may occur at site of intravenous injection and tissue damage if outside
vein. Powerful vesicant (causes blisters) when it contacts skin, mucous
membranes, or eyes. Delayed toxicity -- missed menstrual periods,
alopecia (hair loss), hearing loss, tinnitus (ringing in ears), jaundice,
impaired spermatogenesis and germinal aplasia, swelling, and
hypersensitivity (*Gilman 1980).
Signs and Symptoms of Exposure: Nausea and vomiting; bleeding; skin
lesions; menstrual irregularities ("Oilman 1980).
Medical Conditions Generally Aggravated by Exposure: May damage fetus
in pregnant women (*Gilman 1980).
Emergency and First Aid Procedures: Treat symptoms using procedures
for a general poison (*Rumack 1975 to Present). (Non-Specific --
Poisonous Liquid, n.o.s.) Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Drug used in treatment of cancer (*Gilman 1980) . Formerly used as a gas
warfare agent (*Merck 1976).
-------
CAS Registry Number: 51-75-2
Page 4 of 4
MECHLORETHAMINE
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Poisonous Liquid, n.o.s.) Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site. Do not touch spilled material; stop
leak if you can do so without risk. Use water spray to reduce vapors.
Small spills: absorb with sand or other noncombustible absorbent material
and place into containers for later disposal. Large spills: dike far
ahead of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 51-83-2
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CARBACHOL CHLORIDE
CAS Registry Number: 51-83-2
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 917) Choline,
Chloride, Carbamate; Carbachol; Carbacholin; Carbacholine; Carbacholine
Chloride; Carbacolina; Carbamic Acid, Ester with Choline Chloride;
Carbaminocholine Chloride; Carbaminoylcholine Chloride; Carbamiotin;
Carbamoylcholine Chloride; gamma-Carbamoyl Choline Chloride;
Carbamoylcholine-Hydrochloride; Carbamylcholine Chloride; Carbochol;
Carbocholin; Carbocholine; Carbyl; Carcholin; Choline Carbamate Chloride;
Choline, Chloride Carbamate(Ester); Choline Chloride, Carbamoyl-; Choline
Chlorine Carbamate; Coletyl; Doryl; Doryl (Pharmaceutical); Ethanaminium,
2-((Aminocarbonyl)oxy)-N,N,N-Trimethyl-, Chloride; (2-Hydroxyethyl)Trimethyl
Ammonium Chloride Carbamate; Isopto Carbachol; Jestryl; Lentin; Miostat;
Mistura C; Moryl; P..V. Carbachol; TL 457; Vasoperif
Chemical Formula: C,H1CN000C1
6 15 2 2.
Molecular Weight: 182.68
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: ID. oral (dog)
3 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H?0=l): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 392-401°F, 200-205°C (Merck 1983, p. 245)
Vapor Density (AIR=1): Not Found
-------
CAS Registry Number: 51-83-2
Page 2 of 3
CARBACHOL CHLORIDE
SECTION II — PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g/mL (Merck 1983, p. 245)
Appearance and Odor: Crystalline, odorless, but on standing in an open
container, develops a faint odor resembling that of an aliphatic amine
(Merck 1983, p. 245); hygroscopic prisms or powder (Weast 1979, p. C-246)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: The aqueous solution is stable even when heated
(Merck 1983, p. 245).
Conditions to Avoid: -Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of chloride and nitrogen oxides (Sax 1984, p.
631).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 51-83-2
Page 3 of 3
CARBACHOL CHLORIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Yes (Sax 1984, p. 631)
Ingestion: Yes (Sax 1984, p. 631)
Health Hazards (Acute, Delayed, and Chronic): Highly toxic by mouth
(Sax 1984, p. 631).
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Not Found
SECTION VI -- USE INFORMATION
Cholinergic; parasympathomimetic, used chiefly in large animals,
especially for colic in the horse (Merck 1983, p. 245)
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid skin contact (see Section V above).
COMMENTS
Sources searched but no information found:
DOT 1984
Farm Chemicals Handbook 1984
Oilman 1985
Hayes 1982
Gosselin 1984
Buchel 1983
Clayton and Clayton 1981-82
Hawley 1981
-------
CAS Registry Number: 52-68-6
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- TRICHLOROPHON
CAS Registry Number: 52-68-6
Synonyms: Phosphonic Acid, (2,2,2-Trichloro-l-Hydroxyethyl)-, Dimethyl
Ester; 0,0-Dimethyl 2,2,2-Trichloro-l-Hydroxyethylphosphonate; Phoschlor;
Proxol; Soldep; Trichlorophene; Trinex; Tugon; Vermicide Bayer 2349; Wotexit
Chemical Formula: C.H Cl 0 P
Molecular Weight: 257.45
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: ID- oral (guinea
pig) 420 mg/kg; LC5Q inhalation (rat) 0.0013 mg/liter (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 212°F, 100°C at 1 mmHg (*Hawley 1977)
Specific Gravity (H 0=1): 1.73 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): 7.8 x 10"6 at 20°C (*Merck 1983)
Melting Point: 181-183°F, 83-84°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 15.4 g/100 mL at 25°C (*Merck 1983)
-------
CAS Registry Number: 52-68-6
Page 2 of 4
TRICHLOROPHON
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Crystals, either white ("Merck 1983), pale yellow
(-Clayton and Clayton 1981-82), or colorless (*IARC 1972-85)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Practically nonflammable (*Clayton and
Clayton" 1981-82)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Trichlorofon is an organophosphorus pesticide
(*Encyc Occupat Health and Safety 1983, p. 1627). This material may burn,
but does not ignite readily. For small fires, use dry chemical, carbon
dioxide, water spray, or foam. For large fires, use water spray, fog, or
foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: As for other organophosphorus
pesticides (Encycl Occupat Health and Safety 1983, p. 1627) stay upwind;
keep out of low areas. Move containers from fire area if you can do so
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: As for other organophosphorus
pesticides (Encycl Occupat Health and Safety 1983, p. 1627) container may
explode in heat of fire (DOT 1984, Guide 55). Heat may cause
decomposition and evolution of highly toxic fumes of phosphorus oxides and
chlorides (-Sax 1975).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-IARC 1972-85)
Conditions to Avoid: Decomposes in water at elevated temperatures
and at pH less than 5.5 (*IARC 1972-85).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Decomposes to form dichlorvos
(*IARC 1972-85)
-------
CAS Registry Number: 52-68-6
Page 3 of 4
TRICHLOROPHON
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Student 1981, pp. 507-508)
Skin: Yes (Hayes 1982, p. 301)
Ingestion: Yes (-Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): Very toxic: probable
oral lethal dose (human) 50-500 mg/kg, between 1 teaspoon and 1 ounce for
150 Ib. (70 kg) person. Toxicity relatively low among organic phosphate
insecticides, although a potent cholinesterase inhibitor ("Gosselin
1976). Skin sensitivity has been reported (*Rossoff 1974).
Signs and Symptoms of Exposure: Muscle weakness, twitching,
respiratory depression, sweating, vomiting, diarrhea, chest and abdominal
distress sometimes pulmonary edema, excessive salivation, headache,
giddiness, vertigo and weakness, runny nose and sensation of tightness in
chest (inhalation), blurring of vision, tearing, ocular pain, loss of
muscle coordination, and slurring of speech (*Gosselin 1976, '"Morgan
1982). Skin sensitivity (*Rossoff 1974).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: As for other organophosphorus
pesticides (Encycl Occupat Health and Safety 1983, p. 1627) move victim to
fresh air; call emergency medical care. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. In case of contact
with material, immediately flush skin or eyes with running water for at
least 15 minutes. Speed in removing material from skin is of extreme
importance. Remove and isolate contaminated clothing and shoes at the
site. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Insecticide for non-agricultural uses -- e.g., forests. Insecticide for
vegetables, cotton, alfalfa, corn, deciduous fruits and nuts; livestock,
animal buildings, outdoor and aquatic areas and ornamentals; non-food
fishery uses, domestic dwellings; anthelmintic agent for horses (*SRI).
-------
CAS Registry Number: 52-68-6
Page 4 of 4
TRICHLOROPHON
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
As for other organophosphorus pesticides (Encyc Occupat Health and Safety
1983, p. 1627), stay upwind; keep out of low areas. Ventilate closed
spaces before entering them. Wear positive pressure breathing apparatus
and special protective clothing. Do not touch spilled material; stop leak
if you can do so without risk. Use water spray to reduce vapors. Small
spills: absorb with sand or other non-combustible absorbent material and
place into containers for later disposal. Small dry spills: with clean
shovel place material into clean dry containers and cover; move containers
from spill area. Large spills: dike far ahead of spill for later
disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 53-86-1
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- INDOMETHACIN
CAS Registry Number: 53-86-1
Synonyms: Indole-3-Acetic Acid, 1-(p-Chlorobenzoyl)-5-Methoxy-2-Methyl-;
l-(p-Chlorobenzoyl)-2-Methyl-5-Methoxy-3-Indole-Acetic Acid; l-(p-Chloro-
benzoyl)-5-Methoxy-2-Methyl-3-Indolylacetic Acid; 1-(p-Chlorobenzoyl)-5-
Methoxy-2-Methylindole-3-Acetic Acid; lH-Indole-3-Acetic Acid,
l-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-; alpha-(1-(p-Chlorobenzoyl)-
2-Methyl-5-Methoxy-3-Indolyl)Acetic Acid; Amuno; Artrinovo; Artrivia;
Confortid; Dolovin; Idomethine; Inacid; Indacin; Indo-Rectolmin; Indocid;
Indocin; Indole-3-Acetic Acid, 1-(p-Chlorobenzoyl)-5-Methoxy-2-Methyl-;
Indomecol; Indomed; Indomee; Indometacin; Indometacine; Indomethacine;
Indomethazine; Infrocin; Inteban SP; Metacen; Metartril; Methazine; Metindol;
Mezolin; N-p-Chlorbenzoyl-5-Methoxy-2-Methylindole-3-Acetic Acid; NCI-C56144;
Reumacide; Sadoreum
Chemical Formula: C H 6C1NO,
Molecular Weight: 357.81
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD5Q oral (rat) 12
mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
-------
CAS Registry Number: 53-86-1
Page 2 of 4
INDOMETHACIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Melting Point: 311 or 324°F, 155 or 162°C (depending on the
polymorphic type of crystal) ("Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (*Merck 1976)
Appearance and Odor: Pale-yellow to yellow-tan crystalline powder;
odorless to slight odor (*0sol 1980)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Medicines, (Solid) Poison B,
n.o.s.) Extinguish fire using agent suitable for type of surrounding fire
(material itself burns with difficulty). Use water in flooding quantities
as fog. Use "alcohol" foam, carbon dioxide or dry chemical (Student 1981,
p. 322).
Special Fire Fighting Procedures: (Non-Specific -- Medicines, (Solid)
Poison B, n.o.s.) Wear self-contained breathing apparatus (Student 1981,
p. 322).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of chlorine and nitrogen oxides (Sax 1984, p. 1615).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*0sol 1980)
Conditions to Avoid: Light (*Sunshine 1969); decomposing heat (Sax
1984, p. 1615)
Incompatibility (Materials to Avoid): Decomposed by strong alkali
(Merck 1983, p. 4842)
-------
CAS Registry Number: 53-86-1
Page 3 of 4
INDOMETHACIN
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: .When heated to decomposition,
it emits very toxic fumes of chlorides and nitrogen oxides (Sax 1984, p.
1615).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Yes (*Transdermal Indomethacin
Pharmaceuticals 1983)
Ingestion: Yes (*Gilman 1980)
Health Hazards (Acute, Delayed, and Chronic): This is classified as
very toxic. Probable oral lethal dose in humans is 50-500 mg/kg or
between one teaspoon and one ounce for a 70 kg (150 Ib.) person ("Gosselin
1976).
Signs and Symptoms of Exposure: Gastrointestinal complaints (loss of
appetite, nausea, abdominal pain, ulcers, diarrhea); dizziness;
lightheadedness; mental confusion; severe depression; psychosis;
hypersensitivity reactions (e.g. rashes, asthma, urticaria, etc.); ringing
in the ears; coma and convulsions (-Oilman 1980, *0sol 1980, *Grant
1974). Acute pancreatitis, neutropenia, and thrombocytopenia have also
been reported (Gilman 1985, p. 696).
Medical Conditions Generally Aggravated by Exposure: Persons with
renal disease or ulcerative lesions of stomach or intestines are at risk
(*Gilman 1980). Pregnant women and nursing mothers should be removed from
any possible exposure to this material. Use cautiously for elderly
patients (*AMA 1980).
Emergency and First Aid Procedures: (Non-Specific -- Medicines,
n.o.s.) Move victim to fresh air, call emergency medical care. Remove
and isolate contaminated clothing and shoes at the site. In case of
contact with material, immediately flush skin or eyes with running water
for at least 15 minutes (DOT 1984, Guide 11).
-------
CAS Registry Number: 53-86-1
Page 4 of 4
INDOMETHACIN
SECTION VI -- USE INFORMATION
Material is used as an anti-inflammatory, antipyretic, analgesic
medication (*Merck 1976).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Medicines, (Solid) Poison B, n.o.s.) Avoid breathing
dusts, and fumes from burning materials. Keep upwind. Wear
self-contained breathing apparatus. Avoid bodily contact with the
material. Wear full protective clothing. Wash away any material which
may have contacted the body with copious amounts of water or soap and
water (Student 1981, p. 322).
-------
CAS Registry Number: 54-11-5
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- NICOTINE
CAS Registry Number: 54-11-5
Synonyms: (-)-3-(l-Methyl-2-Pyrrolidyl)Pyridine; l-Methyl-2-(3-Pyridyl)
Pyrrolidine; beta-Pyridyl-alpha-N-Methylpyrrolidine; Destruxol Orchid Spray;
EMO-NIK; ENT 3,424; Flux Maag; Fumetobac; L-3-(l-Methyl-2-Pyrrolidyl)Pyridine;
L-Nicotine; Mach-Nic; Niagara PA Dust; Nic-Sal; Nico-Dust; Nico-Fume;
Nicocide; Nicotin; Nicotine Alkaloid; Ortho N-4 Dust; Ortho N-5 Dust;
Pyridine, 3-(l-Methyl-2-Pyrrolidinyl)-, (S)-; Pyridine, 3-(Tetrahydro-
l-Methylpyrrol-2-yl); Pyrrolidine, l-Methyl-2-(3-Pyridyl)-; Tendust;
Tetrahydronicotyrine, DL-
Chemical Formula: C H ,N.
Molecular Weight: 162.23
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 0.5 mg/m3 (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.5 mg/m3 (skin) (*ACGIH 1983)
IDLH: 35 mg/m3 (NIOSH/OSHA 1978, p. 138-139)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 476.1°F, 246.7°C at 745 mmHg (»Weast 1979)
Specific Gravity (H20=l): 1.0097 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): 1 at 61.8°C (Sax 1984, p. 1997)
Melting Point: -110°F, -79°C (*Weast 1979)
Vapor Density (AIR=1): 5.61 (Sax 1984, p. 1997)
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 54-11-5
Page 2 of 4
NICOTINE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Miscible below 60°C (*Merck 1983)
Appearance and Odor: Colorless to pale yellow, oily liquid (*Merck
1983). Slight, fishy odor when warm (NIOSH/OSHA 1978, pp. 138-139).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Low fire hazard when exposed to heat or flame (Sax
1984, p. 1997)
LEL: 0.75% (Sax 1984, p. 1997)
UEL: 4.0% (Sax 1984, p. 1997)
Extinguishing Methods: Extinguish with alcohol foam, dry chemical, or
carbon dioxide (Sax 1984, p. 1997). Water may cause frothing if it gets
below surface of liquid and turns to steam. However, water fog gently
applied to surface will cause frothing which will extinguish the fire
(*NFPA 1978).
Special Fire Fighting Procedures: Material too dangerous to health to
expose firefighters. A few whiffs of the vapor could cause death; vapor
or liquid could be fatal on penetrating firefighter's normal full
protective clothing. Normal full protective clothing and breathing
apparatus available to the average fire department will not provide
adequate protection against inhalation or skin contact (*NFPA 1978).
Unusual Fire and Explosion Hazards: There is a moderate explosion
hazard when exposed to heat or flame (Sax 1984, p. 1997).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (normal conditions) (*NFPA 1978)
Conditions to Avoid: Heat or flames (-Sax 1975)
Incompatibility (Materials to Avoid): Avoid oxidizing materials (Sax
1984, p. 1997).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits nitrogen oxides, carbon monoxide and other highly toxic fumes
(Sax 1984, p. 1997).
-------
CAS Registry Number: 54-11-5
Page 3 of 4
NICOTINE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1997)
Skin: Yes (Merck 1983, p. 935)
Ingestion: Yes (Sax 1984, p. 1997)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or
a taste (less than 7 drops) for a 70 kg (150 Ibs.) person (*Gosselin
1976). It may be assumed that ingestion of 40-60 mg of nicotine is lethal
to humans. There is fundamental difference between acute toxicity from
use of nicotine as insecticide or from ingestion, and chronic toxicity
that may be caused by prolonged exposure to small doses as occurs in
smoking ("Encyc Occupat Health and Safety 1983). Maternal smoking during
pregnancy is associated with increased risk of spontaneous abortion, low
birth weight and still-birth ("The Chemical Society 1975). Nicotine was
found as a co-carcinogen in animals (*NRC 1977).
Signs and Symptoms of Exposure: Symptoms include extreme nausea,
vomiting, evacuation of bowel and bladder, mental confusion, twitching,
convulsions (Merck 1983, p. 935); burning sensation in mouth and throat,
salivation, abdominal pain, and diarrhea. Gastrointestinal reactions are
less severe and do not occur after skin and respiratory exposure.
Systemic effects include headache, sweating, dizziness, auditory and
visual disturbances, confusion, weakness, and incoordination (*Gosselin
1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care; if not breathing give artificial respiration; if
breathing is difficult, give oxygen; upon eye and skin contact wash with
running water for 15 minutes; immediately remove contaminated clothing and
shoes (DOT 1984, Guide 55).
-------
CAS Registry Number: 54-11-5
Page 4 of 4
NICOTINE
SECTION VI -- USE INFORMATION
It is used as an insecticide, fumigant and in veterinary matters as an
ectoparasiticide and anthelmintic (*Merck 1983). Also, used in tanning
(*NRC 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
The normal full protective clothing and breathing apparatus available to
the average fire department will not provide adequate protection against
inhalation or skin contact with this material (*NFPA 1978). Do not touch
spilled material; stop leak; reduce vapors with water spray. Small
Spills: take up with sand or other noncombustible absorbent material and
place into containers for later disposal. Small Dry Spills: with clean
shovel place material into clean, dry container and cover; move containers
from spill area. Large Spills: dike far ahead of spill for later
disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 54-62-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- AMINOPTERIN
CAS Registry Number: 54-62-6
Synonyms: (NIOSH/RTECS 1983, Synonyms, Volume 2, p. 375) Glutamic
Acid, N-(p-(((2,4-Diamino-6-Pteridinyl)Methyl)Amino)Benzoyl)-, L-;
4-Amino-4-Deoxypteroylglutamate; 4-Amino-PGA; Aminopteridine;
4-Arainopteroylglutamic Acid; A-Ninopterin; APGA; N-(4-((2,4-Diamino-6-
Pteridinyl)Methyl)Amino)Benzoyl)-L-Glutamic Acid; ENT-26079; Folic Acid,
4-Amino-; NSC 739; L-Glutamic Acid, N-[4-[(Diamino-6-Pteridinyl)Methyl]
Am ino]B enzoy1]-
Chemical Formula: C1_HoriNQ0I.
iy zu o j
Molecular Weight: 440.47
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD. oral (rat)
2.5 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
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CAS Registry Number: 54-62-6
Page 2 of 3
AMINOPTERIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Clusters of yellow needles (Hawley 1981, p. 55)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Hawley 1981, p. 55)
Health Hazards (Acute, Delayed, and Chronic): An antimetabolite;
antagonizes the utilization of folic acid by the body. Highly toxic by
ingestion (Hawley 1981, p. 55).
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CAS Registry Number: 54-62-6
Page 3 of 3
AMINOPTERIN
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Pesticide, Solid,
n.o.s.) Move victim to fresh air; call emergency medical care. Remove
and isolate contaminated clothing and shoes at the site. In case of
contact with material, immediately flush eyes with running water for at
least 15 minutes (DOT 1984, Guide 53).
SECTION VI -- USE INFORMATION
Rodenticide (Merck 1983, pp. 70-71); medicine and rodenticide (Hawley
1981, p. 55). Not registered as a rodenticide in the U.S. (USEPA/Active
Ingredients 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Pesticide, Solid, n.o.s.) Do not touch spilled material;
stop leak if you can do so without risk. Use water spray to reduce
vapors. Small spills: absorb with sand or other noncombustible absorbent
material and place into containers for later disposal. Small dry spills:
with clean shovel place material into clean, dry container and cover; move
containers from spill area. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
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CAS Registry Number: 55-91-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ISOFLUORPHATE
CAS Registry Number: 55-91-4
Synonyms: Diisopropyl Fluorophosphate; DFP; Diflupyl; Diflurphate;
Diisopropoxyphosphoryl Fluoride; Diisopropyl Fluorophosphonate; Diisopropyl
Phosphofluoridate; Diisopropyl Phosphorofluoridate; Diisopropylfluoro-
phosphate; Diisopropylfluorophosphoric Acid Ester; Diisopropylphosphoro-
fluoridate; Dyflos; Dyphlos; Floropryl; Fluophosphoric Acid, Diisopropyl
Ester; Fluorodiisopropyl Phosphate; Fluostigmine; Fluropryl; Isofluro-
phosphate; Isopropyl Fluophosphate; Isopropyl Phosphorofluoridate; Neoglaucit;
0,0*-Diisopropyl Phosphoryl Fluoride; 0,0,-Diisopropyl Fluorophosphate; PF-3;
Phosphorofluoridic Acid, Bis(l-Methylethyl) Ester; Phosphorofluoridic Acid,
Diisopropyl Ester; T-1703; TL 466; Fluorophosphoric Acid, Diisopropyl Ester;
Fluoropryl; Isofluorophate; Isoflurophate
Chemical Formula: C,H,.FO,P
6 14 3
Molecular Weight: 184.15
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC_ inhalation
(rat) 0.36 mg/liter/10 mintues (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 144°F, 62°C at 9 mmHg (*Merck 1983)
Specific Gravity (H20=l): 1.055 (*Merck 1983)
Vapor Pressure (mmHg): 0.579 at 20°C (*Merck 1983)
Melting Point: -116°F, -82°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
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CAS Registry Number: 55-91-4
Page 2 of 4
ISOFLUORPHATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1.54% by weight at 25°C (*Merck 1983)
Appearance and Odor: Oily liquid (*Hawley 1981). Clear, colorless or
faintly yellow liquid (*0sol 1980).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphorous Pesticide,
n.o.s.) Dry chemical, carbon dioxide, water spray, or foam. For large
fires, water spray, fog, or foam. Fight fire from maximum distance. Dike
fire control water for later disposal (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Stay upwind; keep out of low areas.
Wear positive pressure breathing apparatus and special protective clothing
(DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: May burn but will not ignite
readily. Container may explode in heat of fire. Fire and runoff from
fire control water may produce irritating or poisonous gases (DOT 1984,
Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Merck 1983)
Conditions to Avoid: Forms hydrofluoric acid in presence of
moisture (*Merck 1983). Keep away from sources of heat (*Farm
Chemicals Handbook 1984). Anhydrous compounds or oil solutions are
stable in glass containers at room temperature (*Merck 1983).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Forms hydrogen fluoride in
presence of moisture; decomposes in water at pH about 2.5 (*Merck 1983).
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CAS Registry Number: 55-91-4
Page 3 of 4
ISOFLUORPHATE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Merck 1983)
Skin: Yes (Sax 1984, p. 1667)
Ingestion: Yes (*Gosselin 1984)
Health Hazards (Acute, Delayed, and Chronic): This is an
organophosphate pesticide (^Morgan 1982). Extremely toxic: probable oral
lethal dose in humans is 5-50 mg/kg, between 7 drops and 1 teaspoonful for
70 kg person (150 Ib.) (*Gosselin 1984). The material is a cholinesterase
inactivator. Even traces of the vapor cause pinpoint pupils (*Merck 1983).
Signs and Symptoms of Exposure: Respiration depression, muscle
weakness, twitching, and convulsions. Sweating, visual disturbances,
vomiting, diarrhea, chest and abdominal distress, and sometimes pulmonary
edema (-Morgan 1982).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Do not inhale vapors; avoid
contact with skin (*Merck 1983). (Non-Specific -- Organophosphorous
Pesticide, n.o.s.) Move victim to fresh air; call emergency medical
care. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Research tool in neuroscience for its ability to inhibit cholinesterase
(by phosphorylation) on an acute/sub-acute basis and to produce a delayed
neuropathy (*Peer Review Committee). An insecticide. Used in Germany as
a basis for "nerve gases" (Sax 1984, p. 1667).
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CAS Registry Number: 55-91-4
Page 4 of 4
ISOFLUORPHATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
When handling in open containers, protect the eyes, nose, and mouth with a
suitable mask, and avoid contact with skin (*0sol 1980).
(Non-Specific -- Organophosphorus Pesticide, n.o.s.) Stay upwind; keep
out of low areas. Ventilate closed spaces before entering them. Wear
positive pressure breathing apparatus and special protective clothing.
Remove and isolate contaminated clothing at the site. Do not touch
spilled material.. Use water spray to reduce vapors. Take up small spills
with sand or other noncombustible absorbent material and place in
containers for later disposal. Dike far ahead of large spills for later
disposal (DOT 1984, Guide 55).
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CAS Registry Number: 56-25-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CANTHARIDIN
/
CAS Registry Number: 56-25-7
Synonyms: 7-Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Anhydride,
2,3-Dimethyl-; 1,2-Dimethyl-3,6-Epoxyperhydrophthalic Anhydride;
4,7-Epoxyisobenzofuran-l,3-Dione, Hexahydro-3a,7a-Dimethyl-, (3a alpha, 4
beta, 7 beta, 7a alpha)-; 2,3-Dimethyl-7-Oxabicyclo[2.2.l]Heptane-2,3-
Dicarboxylic Anhydride; CAN; Cantharides Camphor; Cantharidine; Cantharone;
Exo-l,2-cis-Dimethyl-3,6-Epoxyhexahydrophthalic Anhydride; Hexahydro-3a alpha,
7a alpha-Dimethyl-4 beta, 7 beta-Epoxyisobenzofuran-l,3-dione; Kantaridin
Chemical Formula: C.-H^.O.
10 12 4
Molecular Weight: 196.21
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (human)
0.428 rag/kg (-NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Sublimes at 230°F, 110°C (Merck 1983, p. 242)
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 424°F, 218°C (*Weast 1979)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
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CAS Registry Number: 56-25-7
Page 2 of 3
CANTHARIDIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Insoluble in cold water (*Merck 1976); somewhat
soluble in hot water (*Merck 1976).
Appearance and Odor: Brown to black powder (Sax 1984, p. 627);
orthorhombic plates, scales (Merck 1983, p. 242).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits acrid smoke and irritating fumes ("Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes («Sax 1979)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes ("Arena 1979)
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CAS Registry Number: 56-25-7
Page 3 of 3
CANTHARIDIN
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or
a taste of less than 7 drops for a 70 kg (150 Ib.) person (*Gosselin
1976). It is very toxic by absorption through skin (*Merck 1976).
Signs and Symptoms of Exposure: Symptoms from ingestion include
vomiting, abdominal pain, shock, bloody diarrhea, pain in throat and
stomach, swelling and blistering of tongue, difficulty swallowing,
salivation, slow and painful urination, and thirst. There may be
delirium, fainting, and tetanic convulsions (*Goodman 1975, *Rumack 1975
to Present, "Arena 1979, "Gosselin 1976). Eye contact results in
irritation with much swelling of the lids (*Grant 1974). Initial tissue
reaction upon contact with the skin is swelling followed by blister
formation within 24 hours (*Doull 1980).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: For ingestion, induce vomiting
with syrup of ipecac. For skin contact thoroughly wash contaminated area
with soap and water. Eyes should be irrigated with plain tap water
(*Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
Formerly used as a counter-irritant and vesicant (*IARC 1972-1985). Also
used for the removal of benign epithelial growth, e.g., warts (*Gilman
1980). Used as an experimental antitumor agent. Active ingredient in
Spanish fly, a reputed aphrodisiac ("Peer Review Committee).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact (see Section V above).
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CAS Registry Number: 56-38-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PARATHION
CAS Registry Number: 56-38-2
Synonyms: Phosphorothioic Acid, 0,0-Diethyl O-(p-Nitrophenyl) Ester
(Liquid Mixture); Parathion liquid; Alkron; Aileron; American Cyanamid 3422;
Aphamite; Bayer E-605; Bladan; Diethyl 4-Nitrophenyl Phosphorothionate;
Diethyl p-Nitrophenyl Thionophosphate; Diethyl Parathion; Diethyl-p-Nitrophenyl
Monothiophosphate; DNTP; E 605; ENT 15,108; Ethyl Parathion; Etilon; Folidol;
Fosferno; Fostox; Genithion; NA 2783 (DOT); NCI-C00226; Niran; Nitrostigmine;
0,0-Diethyl 0-(p-Nitrophenyl) Phosphorothioate; 0,0 Diethyl O-(p-nitrophenyl)
Thionophosphate 0,0-Diethyl 0-4-Nitrophenyl Thiophosphate; 0,0-Diethyl 0-p-
Nitrophenyl Phosphorothioate; Oleoparathion; Panthion; Paraflow; Paramar;
Paraphos; Parawet; Phenphos; Phoskil; Phosphenol; Phcsphorothioic Acid
0,0-Diethyl 0-(4-Nitrophenyl) Ester; Rhodir.tox; SNP; Stathion; Sulphos;
Thiophos; Vapophos
Chemical Formula: C H14NO PS
Molecular Weight: 291.27
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 0.1 mg/m3 (skin) (NIOSH 1978, p. 148); ceiling 20
mg/m3 (*IARC 1972-1985)
ACGIH TLV: TWA 0.1 mg/m3 (skin); STEL 0.3 mg/m3 (skin) (ACGIH
1985, p. 26)
IDLH: 20 mg/m3 (*Encyc of Occupat Health and Safety 1983)
Other Limits Recommended: Occupational exposure recommended standard:
Air 0.05 mg/m3 (NIOSH/OSHA 1978, p. 143)
SECTION II — PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 707°F, 375°C (*Merck 1983)
Specific Gravity (H20=l): 1.26 (*Merck 1983)
Vapor Pressure (mmHg): 3.78 x 10"5 at 20°C (^Worthing 1979)
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CAS Registry Number: 56-38-2
Page 2 of 4
PARATHION
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Melting Point: 43°F, 6°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble; 12.4 mg/liter at 20°C
(*Bowman 1979)
Appearance and Odor: Pale yellow liquid; technical grade is brown and
has a garlic-like odor (*Worthing 1979).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 248-320°F, 120-160°C (Method not given)
(*Clayton and Clayton 1981-82)
Flammable Limits: Not highly flammable (*Encyc Occupat Health and
Safety 1971)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Use water spray, dry chemical, foam, or carbon
dioxide (*NFPA 1978).
Special Fire Fighting Procedures: Use water spray to keep fire-exposed
containers cool. If a leak or spill has not ignited, use water spray to
disperse vapors and to provide protection for firefighters. Water spray
may be used to flush spills away from exposures. Fight advanced or
massive fires from a safe distance or from a protected location. Special
protective clothing should be worn; normal protective clothing may be
penetrated (*NFPA 1978).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
can emit toxic fumes of oxides of nitrogen, phosphorus, and sulfur. High
pressure hoses may scatter material from broken containers (*NFPA 1978).
Containers may explode when heated (-CHRIS 1978).
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CAS Registry Number: 56-38-2
Page 3 of 4
PARATHION
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes, in distilled water and in acid solution
(*Hawley 1981)
Conditions to Avoid: Store below 25-30°C (*Farm Chemicals Handbook
1983). It slowly decomposes in air and hydrolyzes in the presence of
alkaline material (*Hawley 1981). Containers may explode when heated
(*CHRIS 1978).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
the material can emit toxic fumes of oxides of nitrogen, phosphorus, and
sulfur (*NFPA 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V — HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Gosselin 1976)
Skin: Yes (*Gosselin 1976)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): This material is
extremely toxic; the probable oral lethal dose is 5-50 mg/kg, or between 7
drops and 1 teaspoonful for a 150-Ib. person. As little as 1 drop can
endanger life if splashed in the eye. Toxicity is highest by inhalation
(*Gosselin 1976).
Signs and Symptoms of Exposure: Symptoms may include nausea, vomiting,
abdominal cramps, diarrhea, excessive salivation, headache, giddiness,
weakness, muscle twitching, difficult breathing, blurring or dimness of
vision, and loss of muscle coordination. Death may occur from failure of
the respiratory center, paralysis of the respiratory muscles, intense
bronchoconstriction, or all three (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: People at special
risk are those with a history of glaucoma, cardiovascular disease, hepatic
disease, renal disease, or central nervous sytem abnormalities (*Encyc
Occupat Health and Safety 1983).
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CAS Registry Number: 56-38-2
Page 4 of 4
PARATHION
SECTION V -- HEALTH HAZARD DATA (Continued)
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
This material is used as an insecticide (*SRI) and is used almost
exclusively in agriculture (Hayes 1982, p. 379).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
In case of leaks or spills, special protective clothing should be worn.
Use water spray to disperse vapors and flush spills away (*NFPA 1978).
Ventilate area of spill or leak. Spills may be absorbed in vermiculite,
ary sand, earth, or a similar material (*NIOSH/OSHA 1981).
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CAS Registry Number: 56-72-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- COUMAPHOS
CAS Registry Number: 56-72-4
Synonyms: 3-Chloro-4-Methyl-7-Coumarinyl Diethyl Phosphorothioate;
3-Chloro-4-Methyl-7-Hydroxycoumarin Diethyl Thiophosphoric Acid Ester;
3-Chloro-4-Methylumbelliferone 0-Ester with 0,0-Diethyl Phosphorothioate;
3-Chloro-7-Hydroxy-4-Methyl-Coumarin 0,0-Diethyl Phosphorothioate; 3-Chloro-
7-Hydroxy-4-Methyl-Coumarin 0-Ester with 0,0-Diethyl Phosphorothioate;
Agridip; Asunthol; Asuntol; Azunthol; Bay 21/199; Bayer 21/199; Baymix; Baymix
50; Co-Ral; Coumafos; Coumarin, 3-Chloro-7-Hydroxy-4-Methyl-, 0-Ester with
0,0-Diethyl Phosphorothioate; Diethyl 3-Chloro-4-Methylumbelliferyl
Thionophosphate; Diethyl Thiophosphoric Acid Ester of 3-Chloro-4-Methyl-
7-Hydroxycoumarin; Diolice; ENT 17,957; Meldane, Meldone, Muscatox,
NCI-C08662; 0,0-Diethyl 3-Chloro-4-Methyl-7-Umbelliferone Thiophosphate;
0,0-Diethyl 0-(3-Chloro-4-Methyl-2-Oxo-2H-Benzopyran-7-yl) Phosphorothioate;
0,0-Diethyl 0-(3-Chloro-4-Methyl-7-Coumarinyl) Phosphorothioate; 0,0-Diethyl
0-(3-Chloro-4-Methylcoumarinyl-7) Thiophosphate; 0,0-Diethyl
0-(3-Chloro-4-Methylumbelliferone) Thiophosphate; 0,0-Diethyl 0-(3-Chloro-4-
Methylumbelliferyl) Phosphorothioate; 0-3-Chloro-4-Methyl-7-Coumarinyl
0,0-Diethyl Phosphorothioate; Phosphorothioic Acid, 0,0-Diethyl Ester, 0-Ester
with 3-Chloro-7-Hydroxy-4-Methylcoumarin; Phosphorothioic Acid, 0-(3-Chloro-
4-Methyl-2-Oxo-2H-l-Benzopyran-7-yl) 0,0-Diethyl Ester; Resistox; Resitox;
Suntol; Umbethion
Chemical Formula: C ,H ,010 PS
Molecular Weight: 362.78
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat) 0.303 mg/liter (*NIOSH/RTECS 1985)
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CAS Registry Number: 56-72-4
Page 2 of 4
COUMAPHOS
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 1.31 at 25°C (*Spencer 1973)
Vapor Pressure (mmHg): 10"7 at 20°C (-Spencer 1973)
Mdting Point: 196°F; 91°C (-Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Merck 1983)
Appearance and Odor: Slightly brownish crystals (-Merck 1983). Slight
odor of sulfur compound (*CHRIS 1978)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This material may burn but does not ignite
easily (*DOT 1984). Extinguish with water, foam, carbon dioxide, or dry
chemicals (*CHRIS 1978)
Special Fire Fighting Procedures: Use organic vapor respirator, rubber
gloves, and goggles (*CHRIS 1978). Dike fire control water for disposal
later (*DOT 1984).
Unusual Fire and Explosion Hazards: Toxic and irritating oxides of
sulfur and phosphorus may form in fire (*CHRIS 1978) .
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Stable in water (*Merck 1983)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Incompatible with piperonyl
butoxide (*Farm Chemicals Handbook 1983)
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CAS Registry Number: 56-72-4
Page 3 of 4
COUMAPHOS
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of sulfur oxides, phosphorus oxides, and
chlorides (Sax 1984, p. 726)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Yes (-'DOT 1984)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): Very toxic, probable
oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 02. for a
70 kg (150 Ib.) person (*Gosselin 1976). May be fatal if inhaled,
swallowed, or absorbed through skin. Contact may cause burns to skin and
eyes (*DOT 1984).
Signs and Symptoms of Exposure: Symptoms consistent with
organophosphate poisoning: nausea, diarrhea, salivation, difficult
breathing, stiffness of legs, blurring of vision, followed by loss of
muscle coordination, convulsions, coma, and death (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed. Keep victim under observation. (*DOT 1984).
SECTION VI -- USE INFORMATION
For control of a wide variety of livestock insects including cattle grubs,
lice, scabies, flies, and ticks; the common ectoparasites of sheep, goats,
horse, swine, and poultry as well as for screwworms in all these animals
(Farm Chemicals Handbook 1983, p. C61).
-------
CAS Registry Number: 56-72-4
Page 4 of 4
COUMAPHOS
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material; stop leak if you can do it without risk.
Use water spray to reduce vapors. Small spills: take up with sand or
other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel, place material into
clean, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (*DOT 1984).
-------
CAS Registry Number: 57-14-7
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DIMETHYLHYDRAZINE
CAS Registry Number: 57-14-7
Synonyms: As-Dimethylhydrazine; Asym Dimethylhydrazine; Asymmetric
Dimethylhydrazine; Dimazin; Dimazine; 1,1-Dimethylhydrazine; Dimethylhydrazine
Unsymmetrical; DMH; Hydrazine, 1,1-Dimethyl; N,N-Dimethylhydrazine;
U-Dimethylhydrazine; UDMH; Uns-Dimethylhydrazine; Unsym-Dimethylhydrazine;
Unsymmetrical-Dimethylhydrazine
Chemical Formula: C0H0N.
2. o 2.
Molecular Weight: 60.10
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 1 mg/m3 (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.5 ppm, 1 mg/m3; STEL 1.0 ppm, 2 mg/m3 (skin)
(•'-ACGIH 1984)
IDLH: 50 ppm (NIOSH/OSHA 1978, p. 88)
Other Limits Recommended: NIOSH Recommended standard for exposure to
hydrazines: 0.15 mg/m3/2 hrs., ceiling concentration (-NIOSH/RTECS
1985). Industrial substance suspect of carcinogenic potential for humans
(ACGIH 1983, p. 43)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 147°F, 63.9°C at 760 mmHg (*Merck 1983).
Specific Gravity (H20=l): 0.7914 at 22°C/4°C (*IARC 1972-1985)
Vapor Pressure (mmHg): 10 at -22°C (*IARC 1972-1985)
Melting Point: -72°F, -58°C (*Merck 1983)
Vapor Density (AIR=1): 1.94 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 57-14-7
Page 2 of 4
DIMETHYLHYDRAZINE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Very soluble (*Encyc Occupat Health and. Safety
1983)
Appearance and Odor: Clear, colorless liquid with characteristic
ammonia-like fish odor (*IARC 1972-1985).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 5°F, -15°C (CC) (*NFPA 1978)
Flammable Limits:
LEL: 2% (*Sax 1979)
UEL: 95% (*Sax 1979)
Extinguishing Methods: Use dry chemical, carbon dioxide, water spray,
or foam for small fires (*DOT 1984). In large fires water fog, carbon
dioxide, and bicarbonate agents may allow flashback and explosive
re-ignition (-CHRIS 1978).
Special Fire Fighting Procedures: Move containers from fire area if it
can be done without risk. Dike fire control water for later disposal, do
not scatter the material. Cool containers that are exposed to flames with
water until well after fire is out, wear positive pressure breathing
apparatus and special protective clothing. Isolate for one-half mile in
all directions if tank car or truck is involved in fire (*DOT 1984).
Unusual Fire and Explosion Hazards: Vapor may explode if ignited in an
enclosed area (*CHRIS 1978). Vapors may travel to a source of ignition
and flashback. Runoff to sewer may create fire or explosion hazard (*DOT
1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (NFPA 1984, p. 325M-43)
Conditions to Avoid: Dangerous when exposed to heat, flame, or
oxidizers (*Sax 1979).
Incompatibility (Materials to Avoid): Dissolves, swells, and
disintegrates many plastics (*CHRIS 1978).
Hazardous Decomposition or Byproducts: When it decomposes,
1,1-dimethylhydrazine gives off toxic nitrogen compound fumes (*Rumack
1975 to Present).
-------
CAS Registry Number: 57-14-7
Page 3 of 4
DIMETHYLHYDRAZINE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 364)
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): This compound exhibits
high acute toxicity as a result of exposure by all routes. Death or
permanent injury may result after very short exposure to small quantities
(""Sax 1975). Chronic exposure may cause pneumonia, liver damage, and
kidney damage (*Rumack 1975 to Present).
Signs and Symptoms of Exposure: Acute exposures may produce eye, nose
and throat irritation, respiratory distress, nausea, and vomiting
(*Clayton and Clayton 1981-82). Other effects include headache, facial
numbness, twitching, pulmonary edema, blood changes, seizures, and coma.
Contact with skin and eyes may cause thermal burns (*Rumack 1975 to
Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing. In case of contact with this material, immediately flush skin
or eyes with running water for at least 15 minutes. Keep victim quiet and
maintain normal body temperatures. Keep victim under observation since
effects may be delayed (*DOT 1984).
SECTION VI -- USE INFORMATION
Major uses include: chemical synthesis; stabilizer for organic peroxide
fuel additives; absorbent for acid gases; photography (*Hawley 1977); base
in rocket fuel formulations (*Merck 1983); stabilizer for plant growth
regulator (*Clayton and Clayton 1981-82).
-------
CAS Registry Number: 57-14-7
Page 4 of 4
DIMETHYLHYDRAZINE
SECTION VII--- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Shut off ignition sources. Do not touch spilled material. Stop leak if
this can be done without risk. Use water spray to reduce vapors. Take up
small spills with sand or other non-combustible absorbent material and
place into containers for later disposal. Dike far ahead of large spills
for later disposal (*DOT 1984). Spills also may be removed with an
aspirator. Transfer to glass container and neutralize with dilute
sulfurfc acid. Drain with copious amounts of water (*Rumack 1975 to
Present). When working with small quantities wear vinyl-coated hand
protection, natural or reclaimed rubber protection, and plastic eye and
face protection. Where possibility of gross splashing exists, wear full
protective clothing (*Encyc Occupat Health and Safety 1971). A gas mask
with an ammonia (GMD) canister protects for 30 minutes against a 1 percent
concentration in air. For longer periods or higher concentrations, use
self-contained breathing apparatus (*CHRIS 1978).
-------
CAS Registry Number: 57-24-9
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- STRYCHNINE
CAS Registry Number-. 57-24-9
Synonyms: Certox; Dolco Mouse Cereal; Kwik-Kil-, Mole Death; Mouse-Mots;
Mouse-Rid; Mouse-Tox; Pied Piper Mouse Seed; Ro-Dex; Sanaseed; Strychnos;
Strychnidin-10-one; Strychnin
Chemical Formula: C21H22N2°2
Molecular Weight: 334.40
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: 150 ug/ra3 (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.15 mg/m3; STEL 0.45 mg/m3 (*ACGIH 1983)
IDLH: 3 mg/m3 (NIOSH/OSHA 1978, p. 168)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 518°F, 270°C at SmmHg (-Merck 1983)
Specific Gravity (H 0=1): 1.36 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): Not Found
Melting Point: 514-554°F, 268-290°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g in 6400 ml (*Merck 1983).
Appearance and Odor: Colorless, transparent crystals or white
crystalline powder; odorless ("Osol 1980).
-------
CAS Registry Number: 57-24-9
Page 2 of 3
STRYCHNINE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Material may burn but does not ignite readily (*DOT
1984).
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish fire using agent suitable for type
of surrounding fire; material itself does not burn or burns with
difficulty. Use water in flooding quantities as fog. Use alcohol foam,
carbon dioxide, or dry chemical (Student 1981, p. 482).
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: When heated, emits highly toxic
fumes (*Sax 1979). Fire may produce irritating or poisonous gases.
Runoff from fire control or dilution water may cause pollution (*DOT 1984)
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*0sol 1980)
Conditions to Avoid: Protect from light ("Merck 1983)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Not Found
Ingestion: Yes (*Gosselin 1976)
-------
CAS Registry Number: 57-24-9
Page 3 of 3
STRYCHNINE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Super toxic; probable
oral lethal dose in humans is less than 5 mg/kg, a taste (less than 7
drops) for a 70 kg (150 Ib.) person. It causes violent generalized
convulsions. Death results from respiratory arrest as the respiratory
muscles are in sustained spasm ("Gosselin 1976). The lowest lethal oral
dose reported for humans is 30 mg/kg (*NIOSH/RTECS 1985).
Signs and Symptoms of Exposure: Within 15 to 30 minutes after
ingestion, violent convulsions, restlessness, apprehension, heightened
acuity of perception, abrupt movements, hyperreflexia, and muscular
stiffness of the face and legs. Minor sensory stimulus may trigger a
violent generalized convulsion lasting 0.5 to 2 minutes (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Remove and
isolate contaminated clothing and shoes at the site (DOT 1984, Guide 53).
SECTION VI -- USE INFORMATION
Material (and its salts) is used for destroying rodents and predatory
animals and for trapping fur-bearing animals (*Merck 1983).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material; stop leak if you can do so without risk.
Small spills: absorb with sand or other noncombustible absorbent material
and place into containers for later disposal. Small dry spills: with
clean shovel place material into clean, dry container and cover; move
containers from spill area. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 53). Avoid breathing dusts, and fumes
from burning materials. Keep upwind. Wear self-contained breathing
apparatus. Avoid bodily contact with the material. Do not handle broken
packages without protective equipment. Wash away any material which may
have contacted the body with copious amounts of water or soap and water
(Student 1981, p. 482).
-------
CAS Registry Number: 57-47-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- PHYSOSTIGMINE
CAS Registry Number: 57-47-6
Synonyms: Calabarine; Carbamic Acid, Methyl-, Ester with Eseroline;
Erserine; "Eserine; Eserolein, Methylcarbamate (Ester); Esromiotin; Ezerin;
Physostol; Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-Hexahydro-1,3a,8-Trimethyl-,
Methylcarbamate (Ester), (3aS-cis)-
Chemical Formula: ci5H2iN302
Molecular Weight: 275.34
SECTION ^ -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: ID oral (mice)
4.5 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 221-223°F, 105-106°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (*Merck 1976)
Appearance and Odor: White, odorless, microcrystalline powder (*0sol
1980)
-------
CAS Registry Number: 57-47-6
Page 2 of 3
PHYSOSTIGMINE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This is a carbamate pesticide (Hayes 1982, p.
436). As for carbamate pesticides, extinguish fire using agent suitable
for type of surrounding fire (material itself burns with difficulty). Use
water in flooding quantities as fog. Use alcohol foam, carbon dioxide or
dry chemical (Student 1981, p. 104).
Special Fire Fighting Procedures: This is a carbamate pesticide (Hayes
1982, p. 436). As for carbamate pesticides, wear self-contained breathing
apparatus when fighting fires (Student 1981, p. 104).
Unusual Fire and Explosion Hazards: It is a slight fire hazard (Sax
1984, p. 2228).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Keep from light and heat (*Merck
1976).
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits toxic fumes of nitrogen oxides (Sax 1984, p. 2228).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Gilman 1980)
Skin: Yes (*Gilman 1980)
Ingestion: Yes (*Gilman 1980)
-------
CAS Registry Number: 57-47-6
Page 3 of 3
PHYSOSTIGMINE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Super toxic. Probable
oral lethal dose is less than 5 mg/kg for a 70 kg (150 Ib.) person
(*Gosselin 1984). Material is a cholinesterase inhibitor. Effects of
exposure may involve the respiratory, gastrointestinal, cardiovascular and
central nervous systems. Death occurs due to respiratory paralysis or
impaired cardiac function. Time to death may vary from 5 minutes to 24
hours, in severely poisoned patients, depending on factors such as the
dose and route (^Goodman 1980).
Signs and Symptoms of Exposure: General symptoms include: increased
secretions, fatigability and generalized weakness, involuntary twitching,
severe weakness of skeletal muscles. Symptoms of exposure to material by
major organ system: gastrointestinal: lack of appetite, nausea and
vomiting, abdominal cramps and diarrhea. Central nervous system:
confusion, uncoordination, slurred speech, loss of reflexes, rapid,
irregular breathing, generalized convulsions, and coma. Cardiovascular:
slowed heart beat resulting in hypotension and fall in cardiac output
(*Goodman 1980).
Medical Conditions Generally Aggravated by Exposure: Persons with
asthma and/or persons that require drugs containing choline esters are at
risk (*0sol 1975).
Emergency and First Aid Procedures: Administer artificial respiration
and oxygen if needed (Sax 1984, p. 2228). If the victim's skin and hair
are contaminated, bathe with soap and water. If the material was
ingested, the stomach must be emptied (^Morgan 1976).
SECTION VI -- USE INFORMATION
Physostigmine is a carbamate pesticide (Hayes 1982, p. 436). Material is
used as a cholinergic (anticholinesterase) agent and as a veterinary
medication (*Merck 1976). Listed as a carbamate pesticide in Sections III
and VII, however, physostigmine is not registered in the U.S. as such
(USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
This is a carbamate pesticide (Hayes 1982, p. 436). As for other
carbamate pesticides, avoid breathing dusts, and fumes from burning
materials. Keep upwind. Wear self-contained breathing apparatus. Avoid
bodily contact with the material. Wear full protective clothing. Wash
away any material which may have contacted the body with copious amounts
of water or soap and water (*Student 1981).
-------
CAS Registry Number: 57-57-8
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PROPIOLACTONE, beta-
CAS Registry Number: 57-57-8
Synonyms: beta-Propiolactone; 2-Oxetanone; 3-Hydroxypropionic Acid
Lactone; 3-Hydro'xypropionic Acid, beta-Lactone; 3-Propanolide;
3-Propiolactone; beta-Propionolactone; beta-Proprolactone; Betaprone; BPL;
Hydracrylic Acid Beta-Lactone; Hydracrylic Acid, beta Lactone; Propanoic Acid,
3-Hydroxy-,beta-Lactone; Propanolide; Propiolactone; Propionic Acid
3-Hydroxy-beta-Lactone; Propionic Acid, 3-Hydroxy-, beta-Lactone
Chemical Formula: C3H402
Molecular Weight: 72.06
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.5 ppm, 1.5 mg/m3; STEL 1 ppm, 3 mg/m3 (ACGIH,
1983, p. 30)
IDLH: Not Found
Other Limits Recommended: Industrial substance suspect of carcinogenic
potential for humans (ACGIH 1984, p. 41). Toxicity information: LC
inhalation (rat) 0.074 mg/liter (*NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 324°F, 162°C, decomposes (*Merck 1976) .
Specific Gravity (H20=l): 1.146 at 20°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 3.4 at 25°C (*IARC 1972-1985)
Melting Point: -27°F, -33°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 57-57-8
Page 2 of 3
PROPIOLACTONE, beta-
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: 37% by volume (*Merck 1976)
Appearance and Odor: A colorless liquid with a slightly sweetish,
pungent odor (-Encyc Occupat Health and Safety 1971; *IARC 1972-1985)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
t
Flash Point (Method Used): 70°C (158°F) (no method given) (*Merck 1976)
Flammable Limits:
LEL: 2.9% (*NFPA 1979)
UEL: Not Found
Extinguishing Methods: Alcohol foam (*Sax 1979). Extinguish with
water, dry chemical, foam, or carbon dioxide (Weiss 1980, p. 776).
Special Fire Fighting Procedures: Wear air mask, goggles or face
shield, rubber gloves, and protective clothing to prevent all skin
contact. Cool exposed containers with water (Weiss 1980, p. 776).
Unusual Fire and Explosion Hazards: Containers may explode (Weiss
1980, p. 776). When heated to decomposition, it emits acrid smoke and
fumes (Sax 1984, p. 2102).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes, stable when stored at 5°C (-Merck 1983)
Conditions to Avoid: Avoid storing in areas of exposure to the
direct rays of the sun and in areas of high fire hazard (*Sax 1968).
Tends to polymerize on storage (*IARC 1972-1985).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits acrid smoke and fumes (Sax 1984, p. 2102).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Avoid elevated temperatures (Weiss 1980, p.
776).
-------
CAS Registry Number: 57-57-8
Page 3 of 3
PROPIOLACTONE, beta-
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Sax 1968)
Skin: Yes (Weiss 1980, p. 776)
Ingestion: Yes (*Sax 1968)
Health Hazards (Acute, Delayed, and Chronic): The toxicity potential
of this material via inhalation or ingestion is high; may cause death or
permanent injury after very short exposures to small quantities ("Sax
1968). It is a carcinogen (Weiss 1980, p. 776).
Signs and Symptoms of Exposure: Inhalation causes irritation of nose,
throat, and respiratory tract. Contact of liquid with eyes causes
irritation and tears. Contact with skin causes irritation and blistering;
fluid from blisters may cause additional blistering of adjacent skin.
Ingestion causes burns of mouth and stomach (Weiss 1980, p. 776).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Get medical attention following
all exposures to this compound. In case of inhalation, move victim to
fresh air; if breathing has stopped, give artificial respiration. If
there has been eye contact, flush eyes with water for at least 15
minutes. In case of skin contact, flush with water (Weiss 1980, p. 776).
SECTION VI -- USE INFORMATION
Intermediate in organic synthesis; disinfectant (*Merck 1976); sterilant
for blood plasma, tissue grafts, vaccines, enzymes and surgical
instruments (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid contact with liquid. Keep people away. Wear rubber overclothing.
Stop discharge (Weiss 1980, p. 776). Avoid inhalation (see Section V
above).
-------
CAS Registry Number: 57-64-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- PHYSOSTIGMINE, SALICYLATE (1:1)
CAS Registry Number: 57-64-7
Synonyms: (SANSS 1983 Synonyms): Eserine Salicylate; Physostol
Salicylate; Salicylic Acid, compound with Physostigmine; Behzpic Acid,
2-Hydroxy-, compound with (3aS-cis)-l,2,3,3a,8,8a-Hexahydro,-l,3a,8-
Trimethylpyrrolo[2,3-b]indol-5-yl Methylcarbamate (1:1)
Chemical Formula: C.-H-.N.O •C-H..O,
lj zl o / / b o
Molecular Weight: 413.52
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD5_ oral (mouse)
2.5 tng/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 365-369°F, 185-187°C (Merck 1983, p. 1065)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 gram/75 mL at 25°C (Merck 1983, p. 1065)
Appearance and Odor: Crystal form that turns red on exposure to heat
or light (Merck 1983, p. 1065); odor not found.
-------
CAS Registry Number: 57-64-7
Page 2 of 3
PHYSOSTIGMINE, SALICYLATE (1:1)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of nitrogen oxides (Sax 1984, p. 2228).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 2228)
Health Hazards (Acute, Delayed, and Chronic): This compound is similar
to physostigmine. It is classified as super toxic. The probable oral
lethal dose (humans) is less than 5 mg/kg or a taste for a 150 Ib.
person. It is a cholinesterase inhibitor (Gosselin 1984, p. 11-245).
-------
CAS Registry Number: 57-64-7
Page 3 of 3
PHYSOSTIGMINE, SALICYLATE (1:1)
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: This compound is similar to
physostigmine (Gosselin 1984, p. 11-245). Symptoms include nausea,
vomiting, abdominal cramps, diarrhea, excessive salivation, sweating,
lassitude, weakness, tightness in chest, vision disorders, tearing,
ciliary muscle spasm, loss of muscle coordination, slurring of speech,
twitching of muscle, difficulty in breathing, bluing of skin, convulsions,
coma and death (Gosselin 1984, p. 111-89).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: This compound is similar to
physostigmine (Gosselin 1984, p. 11-245). Give oxygen and artificial
respiration as needed. Wash contaminated areas of the skin with soap and
water. Irrigate the eyes with water or saline. Keep patient under
constant observation for at least 24 hours (Gosselin 1984, p. 111-89).
SECTION VI -- USE INFORMATION
Not Found
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Not Found
COMMENTS
Sources searched but no information found:
Doull 1980
Clayton and Clayton 1981-82
NFPA 1984
-------
CAS Registry Number: 57-74-9
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CHLORDANE
CAS Registry Number: 57-74-9
Synonyms: 1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-Hexahydro-4,7 -
Methanoindene; 1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-Hexahydro-4,7-Methylene
Indane; 4,7-Methano-lH-Indene, 1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-
Hexahydro-; 4,7-Methanoindan, 1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-Tetrahydro-;
1068; Aspon-Chlordane; CD 68; Chlor Kil; Chlordane,' Liquid (DOT); Chlorindan;
Corodan; Dowchlor; ENT 9,932; ENT-9932; HCS 3260; Kypchlor; M 140; M 410;
NCI-C00099; Niran; Octa-Klor; Octachloro-4,7-Methanohydroindane; Octachloro-
4,7-Methanotetrahydroindane; Octachlorodihydrodicyclopentadiene; Oktaterr;
Ortho-Klor; Synklor; TAT Chlor 4; Topiclor; Toxichlor; Velsicol 1068; Belt
Chemical Formula: C.-H.Cl..
ID D O
Molecular Weight: 409.80
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 500 yg/m3 (skin) (-NIOSH/RTECS 1985)
ACGIH TLV: 0.5 mg/m3; STEL 2 mg/m3, skin (-ACGIH 1983)
IDLH: 500 mg/m3 (-Clayton and Clayton 1981-82)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 347°F, 175°C at 2 mmHg (-Sunshine 1969)
Specific Gravity (H20=l): 1.56-1.57 at 25°C/0°C (*Merck 1983)
Vapor Pressure (mmHg): 1 x 10" at 25°C (-Sunshine 1969)
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
-------
CAS Registry Number: 57-74-9
Page 2 of 4
CHLORDANE
SECTION II — PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Merck 1983)
Appearance and Odor: Amber viscous liquid with an aromatic, slightly
pungent odor (*Merck 1983, *CHRIS 1978)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Flammable/combustible (*DOT 1984)
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray, and foam. Large fires: water spray, fog, or foam. Move
containers from fire area if it can be done without risk. Cool containers
that are exposed to flames with water from the side until well after fire
is out (*DOT 1984).
Special Fire Fighting Procedures: Isolate hazard area and deny entry.
Stay upwind. Wear positive pressure breathing apparatus and special
protective clothing. Isolate for 1/2-mile in all directions if tank car
or truck is involved in the fire (-DOT 1984).
Unusual Fire and Explosion Hazards: Flammable/combustible material;
may be ignited by heat, sparks or flames. Vapors may travel to a source
of ignition and flash back. Run-off to sewers may create fire or
explosion hazard. Containers may explode in heat of fire. Vapors are
toxic indoors and outdoors (-DOT 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Verschueren 1983, pp. 380-381)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Loses chlorine in presence of
alkaline reagents; should not be formulated with any solvent, carrier,
diluent or emulsifier which has alkaline reaction ("Merck 1983).
-------
CAS Registry Number: 57-74-9
Page 3 of 4
CHLORDANE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: Chlordane degrades under
natural environmental conditions to photoisomers, such as photo-cis-
chlordane, which are more toxic to certain animals than chlordane and also
showed higher bioaccumulation ("Khan et al. 1970).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Gosselin 1984, pp. III-108-109)
Skin: Yes -- More toxic to humans than by oral
administration (Gosselin 1984, pp. III-108-109)
Ingestion: Yes (Gosselin 1984, pp. III-108-109)
Health Hazards (Acute, Delayed, and Chronic): Fatal oral dose to adult
humans is between 6 and 60 g with onset of symptoms within 45 minutes to
several hours after ingestion, although symptoms have occurred following
very small doses either orally or by skin exposure. Some reports of
delayed development of liver disease, blood disorders and upset stomach.
Chlordane is considered to be borderline between a moderately and highly
toxic substance (Gosselin 1984, pp. III-108-109).
Signs and Symptoms of Exposure: Increased sensitivity to stimuli,
tremors, muscular incoordination, and convulsions with or without coma
(Gosselin 1984, pp. III-108-109).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air and give
artificial respiration if indicated. Remove and isolate contaminated
clothing and shoes at site. If exposure to skin or eyes, flush with
running water for at least 15 minutes. Try to keep victim quiet. Effects
may be delayed so keep victim under observation (*DOT 1984).
SECTION VI -- USE INFORMATION
As of 1983, the only use in USA is for termite control (*IARC 1972-1985).
Previously used as agricultural home and garden pesticide or insecticide
(*SRI).
-------
CAS Registry Number: 57-74-9
Page 4 of 4
CHLORDANE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors (see Section V above). Shut off ignition sources.
Eliminate all smoking or flames in hazard area. Do not touch spilled
material. Use water spray to reduce vapors. Stay upwind. Wear positive-
pressure breathing apparatus and full protective clothing. Small spills:
take up with sand or other noncombustible absorbent material, place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (''-DOT 1984).
-------
CAS Registry Number: 58-36-6
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PHENOXARSINE, 10,10'-OXYDI-
CAS Registry Number: 58-36-6
Synonyms: (SANSS 1983 Synonyms) 10H-Phenoxarsine, 10,10'-oxybis;
Bis(Phenoxarsin-10-yl)Ether; Bis(lO-Phenoxarsinyl) Oxide; Bis(lO-Phenoxarsyl)
Oxide; Estabex ABF; OBPA; SA 546; DID 47
Chemical Formula: C24H16As203 (Merck 1983, p. 998)
Molecular Weight: 502.23 (Merck 1983, p. 998)
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: 0.5 mg/m3 (Organic Arsenic Compounds) (OSHA 1984, p. 661)
ACGIH TLV: Air: TWA 0.2 mg (Arsenic)/m3 (ACGIH 1984, p. 10)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
low
(guinea pig) 12.8 mg/liter; LD oral (guinea pig) 24 mg/kg
(*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 363-365°F, 184-185°C (Merck 1983, p. 998)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 58-36-6
Page 2 of 4
PHENOXARSINE, 10,10'-OXYDI-
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Practically insoluble (5 ppm at 20°) (Merck 1983,
p. 998)
Appearance and Odor: Colorless crystals (Merck 1983, p. 998)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Arsenic Compound, Solid,
n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or
foam. Large fires: water spray, fog, or foam. Move container from fire
area if you can do so without risk (DOT 1984, Guide 53).
Special Fire Fighting Procedures: (Non-Specific -- Arsenic Compound,
Solid, n.o.s.) Stay upwind; keep out of low areas. Wear self-contained
(positive pressure if available) breathing apparatus and full protective
clothing (DOT 1984, Guide 53).
Unusual Fire and Explosion Hazards: (Non-Specific -- Arsenic
Compounds) When heated to decomposition, it emits highly toxic fumes of
arsenic (Sax 1984, p. 320).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 58-36-6
Page 3 of 4
PHENOXARSINE, 10,10'-OXYDI-
SECTION V -- HEALTH HAZARD DATA ,
Routes of Entry: Inhalation: Yes (Non-Specific -- Arsenic Compounds)
(Sax 1984, p. 320)
Skin: Yes (Non-Specific -- Arsenic Compounds)
(Sax 1984, p. 320)
. Ingestion: Yes (Non-Specific -- Arsenic Compounds)
(Sax 1984, p. 320)
Health Hazards (Acute, Delayed, and Chronic): (Non-Specific -- Arsenic
Compounds) Arsenic compounds are acutely poisonous by ingestion.
Ingestion or inhalation may result in chronic poisoning. Arsenic
compounds are recognized carcinogens of the skin, lungs, and liver (Sax
1984, p. 320).
Signs and Symptoms of Exposure: (Non-Specific -- Arsenic Compounds)
Ingestion causes nausea, vomiting, and diarrhea. In severe cases, there
may be bloody vomitus and stools and the victim may suffer collapse and
shock with weak, rapid pulse, cold sweats, coma, and death. Symptoms of
chronic poisoning may include loss of appetite, cramps, nausea,
constipation or diarrhea, jaundice, itching and pigmentation of the skin
(Sax 1984, p. 320).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-specific -- Arsenic Compound,
Solid, n.o.s.) Move victim to fresh air; call emergency medical care.
Remove and isolate contaminated clothing and shoes at the site. In case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes (DOT 1984, Guide 53).
SECTION VI -- USE INFORMATION
This material is used primarily for fungicidal and bactericidal protection
of plastics (Merck 1983, p. 998).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Arsenic Compound, Solid, n.o.s.) Keep unnecessary people
away; isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Wear self-contained (positive pressure if available) breathing
apparatus and full protective clo.thing. Do not touch spilled material;
stop leak if you can do so without risk. Small spills: absorb with sand
or other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53).
-------
CAS Registry Number: 58-36-6
Page 4 of 4
PHENOXARSINE, lOJO'-OXYDI-
COMMENTS
Sources searched but no information found:
ACGIH 1983
NIOSH/OSHA 1978
Hawley 1981
Weast 1979
NFPA 1984
Student 1981
Weilss 1980
CHRIS 1978
Doiill 1980
Clayton and Clayton 1981-82
Arena 1979
Gosselin 1984
Encyc Occupat Health and Safety 1983
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
Physicians' Desk Reference 1985
Oilman 1985 '
-------
CAS Registry Number: 58-89-9
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- LINDANE
CAS Registry Number: 58-89-9
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 1,000): Cyclohexane,
1,2,3,4,5,6-Hexachloro-, Gamma-Isomer; Aalindan; Aficide; Agrisol G-20;
Agrocide; Agrocide 2; Agrocide 7; Agrocide 6G; Agrocide III; Agrocide WP;
Agronexit; Ameisenatod; Ameisenmittel Merck; Aparasin; Aphtiria; Aplidal;
Arbitex; BBH; Ben-Hex; Bentox 10; Benzene Hexachloride-gamma-isomer;
gamma-Benzene Hexachloride; Bexol; BHC; gamma-BHC; Celanex; Chloresene;
Codechine; DBH; Detmol-Extrakt; Detox 25; Devoran; Dol Granule; Drill
Tox-Spezial Aglukon; Ent 7,796; Entomoxan; Exagama; Forlin; Gallogama;
Gamacid; Gamaphex; Gamene; Gammahexa; Gammahexane; Gammalin; Gammalin 20;
Gammaterr; Gammex; Gammexane; Gammopaz; Gexane; HCCH; HCH; gamma-HCH;
Heclotox; Hexa; Hexachloran; gamma-Hexachloran; Hexachlorane; gamma-
Hexachlorane; gamma-Hexachlorobenzene; 1-alpha,2-alpha,3-beta,4-alpha,
5-alpha,6-beta-Hexachlorocyclohexane; gamma-Hexachlorocyclohexane; gamma-
1,2,3,4,5,6-Hexachlorocyclohexane; Hexachlorocyclohexane, gamma-Isomer;
1,2,3,4,5,6-Hexachlorocyclohexane, gamma-Isomer; Hexatox; Hexaverm; Hexicide;
Hexyclan; HGI; Hortex; Inexit; Isotox; Jacutin; Kokotine; Kwell; Lendine;
Lentox; Lidenal; Lindafor; Lindagam; Lindagrain; Lindagranox; gamma-Lindane;
Lindane (DOT); Lindapoudre; Lindatox; Lindosep; Lintox; Lorexane; Milbol 49;
Mszychol; NCI-C00204; NEO-Scabicidol; Nexen FB; Nexit; Nexit-Stark; Nexol-E;
Nicochloran; Novigam; Omnitox; Ovadziak; Owadzlak; Pedraczak; Pflanzol;
Quellada; Sang gamma; Silvanol; Spritz-Rapidin; Spruehpflanzol; Streunex; Tap
85; TRI-6; Viton
Chemical Formula: C,H,C1, (Weast 1979, p. C-262)
DO O
Molecular Weight: 290.83 (Weast 1979, p. C-262)
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: 0.5 mg/mj (NIOSH/OSHA 1978, p. 120)
ACGIH TLV: TWA 0.5 mg/m3; STEL 1.5 mg/m3 (skin) (ACGIH 1983, p. 23)
IDLH: 1,000 mg/m3 (NIOSH/OSHA 1978, p. 120)
Other Limits Recommended: Not Found
-------
CAS Registry Number: 58-89-9
Page 2 of 4
LINDANE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 614°F, 323.4°C (Weast 1979, p. C-262); Decomposes
(NIOSH/OSHA 1978, p. 120)
Specific Gravity (H20=l): 1.9 (DASE 1980, p. 529)
Vapor Pressure (mmHg): 9.4 x 10"6 at 20°C (Merck 1983, p. 789)
Melting Point: 234.5°F, 112.5°C (Weast 1979, p. C-262)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (Weast 1979, p. C-262)
Appearance and Odor: Colorless solid with a musty odor; pure material
is odorless (NIOSH/OSHA 1978, p. 120).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Use dry chemical, carbon dioxide, water spray,
or foam for small fires. Use water spray, fog, or foam for large fires.
Move container from fire area if this can be done without risk. Use water
to keep fire-exposed containers cool (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Isolate hazard area and deny entry.
Stay upwind and keep out of low areas. Ventilate closed spaces before
entering. Wear positive pressure breathing apparatus and special
protective clothing. Fight fire from maximum distance, dike fire control
water for later disposal (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, this
compound emits toxic fumes of chlorine, hydrochloric acid, and phosgene
(Sax 1984, p. 366).
-------
CAS Registry Number: 58-89-9
Page 3 of 4
LINDANE
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Thermal decomposition products
may include chlorine, hydrochloric acid, and phosgene (Sax 1984, p. 366).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Gosselin 1984, p. III-240)
Skin: Yes (Gosselin 1984, p. III-240)
Ingestion: Yes (Gosselin 1984, p. III-240)
Health Hazards (Acute, Delayed, and Chronic): Lindane is a stimulant
of the nervous system, causing violent convulsions that are rapid in onset
and generally followed by death or recovery with 24 hours (Hayes 1982, p.
218). The probable human oral lethal dose is 50-500 mg/kg, or between 1
teaspoon and 1 ounce for a 150-lb (70 kg) person (Gosselin 1984, p.
11-286).
Signs and Symptoms of Exposure: Contact with eyes or skin may produce
irritation (BASE 1980, p. 529). Vomiting, faintness, tremor,
restlessness, muscle spasms, unsteady gait, and convulsions may occur as a
result of exposure. Elevated body temperature and pulmonary edema have
been reported in children. Coma, respiratory failure and death can
result. Exposure to vapors of this compound or its thermal decomposition
products may lead to headache, nausea, vomiting, and irritation of the
eyes, nose, and throat (Gosselin 1984, pp. III-240, 241).
Medical Conditions Generally Aggravated by Exposure: Not Found
-------
CAS Registry Number: 58-89-9
Page 4 of 4
LINDANE
SECTION V -- HEALTH HAZARD DATA (Continued)
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes,
speed in removing material from the skin is of extreme importance. Remove
and isolate contaminated clothing and shoes at the site. Keep victim
quiet and maintain normal body temperature. Effect may be delayed; keep
victim0 under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Pesticide (Hawley 1981, p. 617) and scabicide (Hayes 1982, p. 221).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material. Sweep or shovel material into a clean, dry
container. Carefully collect remainder. Use protective, gloves, eye
protection, breathing protection, and special protective clothing (DASE
1980, p. 529; DOT 1984, Guide 55).
-------
CAS Registry Number: 59-88-1
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PHENYLHYDRAZINE HYDROCHLORIDE
CAS Registry Number: 59-88-1
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 457): Hydrazine,
Phenyl-, Hydrochloride; Hydrazine, Phenyl-, Monohydrochloride; Phenylhydrazine
Monohydrochloride; Phenylhydrazinium Chloride
Chemical Formula: C,H.N_«HC1
Do/
Molecular Weight: 144.62
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Occupational exposure to hydrazines
recommended standard: ceiling 0.6 mg/m3/2 hours (Air) (Sax 1984, p.
2190). Toxicity information: LD. oral (rabbit) 25 mg/kg
(*NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not pertinent; it decomposes (Weiss 1980, p. 744)
Specific Gravity (H 0=1): Greater than 1 at 20°C (Weiss 1980, p. 744)
Vapor Pressure (mmHg): Not Found
Melting Point: 469-475°F, 243-246°C (Merck 1983, p. 1051)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Freely soluble (Merck 1983, p. 1051)
Appearance and Odor: White to tan solid; weak aromatic odor (Weiss
1980, p. 744).
-------
CAS Registry Number: 59-88-1
Page 2 of 3
PHENYLHYDRAZINE HYDROCHLORIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Combustible (Weiss 1980, p. 744)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Use water, foam, dry chemical, or carbon
dioxide (Weiss 1980, p. 744).
Special Fire Fighting Procedures: Wear goggles and self-contained
breathing apparatus (Weiss 1980, p. 744).
Unusual Fire and Explosion Hazards: Toxic and irritating hydrogen
chloride and oxides of nitrogen may be produced in fire (Weiss 1980, p.
744).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 744)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): May be corrosive to metals
(Weiss 1980, p. 744).
Hazardous Decomposition or Byproducts: Hydrogen chloride and oxides of
nitrogen (Weiss 1980, p. 744).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 744)
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Weiss 1980, p. 744)
Skin: Yes (Weiss 1980, p. 744)
Ingestion: Yes (Weiss 1980, p. 744)
Health Hazards (Acute, Delayed, and Chronic): This material is
poisonous if swallowed or if fumes are inhaled. Dust is irritating to
eyes, nose, and throat. Phenylhydrazine is a chronic poison (Weiss 1980,
p. 744). Phenylhydrazine is an industrial substance suspect of
carcinogenic potential for humans (ACGIH 1983, p. 43).
-------
CAS Registry Number: 59-88-1
Page 3 of 3
PHENYLHYDRAZINE HYDROCHLORIDE
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Ingestion or inhalation of fumes can
cause nausea, jaundice, anorexia, and blood clots. It may also cause
anemia and liver injury. Contact with eyes causes irritation. Contact
with skin causes irritation and dermatitis. Inhalation of dust can cause
coughing and difficult breathing (Weiss 1980, p. 744).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air. Remove
contaminated clothing and shoes. For ingestion, give a large amount of
water; induce vomiting. If eyes are exposed, flush with water for at
least 15 minutes. If skin is exposed, flush with water (Weiss 1980, p.
744).
SECTION VI -- USE INFORMATION
Hemolytic (Merck 1983, p. 1051).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Wear rubber overclothing, including gloves. Avoid contact with solid and
dust. Restrict access. Disperse and flush (Weiss 1980, p. 744).
(Non-Specific -- Phenylhydrazine) Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas. Wear
self-contained (positive pressure if available) breathing apparatus and
full protective clothing. Do not touch spilled material; stop leak if you
can do it without risk. Small spills: take up with sand or other
noncombustible absorbent material and place into containers for later
disposal. Small dry spills: with clean shovel place material into clean,
dry container and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal (DOT 1984, Guide 53).
-------
CAS Registry Number: 60-34-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- METHYLHYDRAZINE
CAS Registry Number: 60-34-4
Synonyms: 1-Methylhydrazine; Hydrazine, Methyl-; Hydrazomethane; MMH;
Monomethylhydrazine; UN 1244
Chemical Formula: CH,N_
D Z
Molecular Weight: 46.07
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Ceiling 0.35 mg/m3 (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: Ceiling 0.35 mg/m3 (skin) (*ACGIH 1983)
IDLH: 5 ppm (*Encyc Occupat Safety and Health 1983)
Other Limits Recommended: Methylhydrazine is a suspected human
carcinogen with a NIOSH recommended ceiling concentration of 0.08
mg/m3/2 hour ("ACGIH 1984 and *NIOSH 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 190°F, 87.5°C (*Merck 1983)
Specific Gravity (H20=l): 0.874 at 25°C (*Merck 1983)
Vapor Pressure (mmHg): 49.6 at 25°C (^Sunshine 1969)
Melting Point: -62.3°F, -52.4°C (*Merck 1983)
Vapor Density (AIR=1): 1.6 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible with water (*Merck 1983)
Appearance and Odor: It is a colorless liquid (*Sax 1979) with an odor
characteristic of short-chain, organic amines, or ammonia-like (*Merck
1983, *Clayton and Clayton 1981-82).
-------
CAS Registry Number: 60-34-4
Page 2 of 4
METHYLHYDRAZINE
\
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 70°C (OC) (*Merck 1983)
Flammable Limits:
LEL: 2.5% (Sax 1984, p. 1858)
UEL: 97% (Sax 1984, p. 1858)
Extinguishing Methods: For small fires, use dry chemical, carbon
dioxide, water spray, and foam. For large fires, use water spray, fog, or
foam. Keep unnecessary people away and isolate the hazardous area. Stay
upwind and keep out of low-lying areas (DOT 1984, Guide 28). Fire exposed
containers should be kept cool with water. Use water spray to disperse
vapors and protect men attempting to stop a leak which has not ignited
("NFPA 1978). Move container from fire area if it can be done without
risk (*DOT 1984).
Special Fire Fighting Procedures: Wear positive pressure breathing
apparatus and special (full) protective clothing. No skin surface should
be exposed (*NFPA 1978). Isolate area for 1/2-mile in all directions if a
tank car or truck is involved in a fire (DOT 1984, Guide 28).
Unusual Fire and Explosion Hazards: Extremely flammable; ignites
spontaneously under almost all normal temperature conditions (*NFPA
1978). Water used to extinguish a fire may cause pollution and should be
diked for later disposal (DOT 1984, Guide 28). Water may be ineffective
in extinguishing fires due to the chemical's low flash point. Because of
the wide flammability limits, low flash point, and reignition hazard, dry
chemicals, carbon dioxide, water spray, and foam may not be as effective
as water dilution of fire area. The vapor is heavier than air; thus it
may accumulate sufficiently to flash back ("NFPA 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: Heat or flame should be avoided because
chemical is extremely flammable and explosive (*Sax 1979).
Incompatibility (Materials to Avoid): Ignites spontaneously in air
when in contact with porous materials (e.g., earth, asbestos, wood, or
cloth) ('VNFPA 1978). Also ignites spontaneously on contact with strong
oxidizing agents (e.g., fluorine, chlorine trifluoride, fuming nitric
acid, and nitrogen tetroxide) (*Merck 1983).
-------
CAS Registry Number: 60-34-4
Page 3 of 4
METHYLHYDRAZINE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: Methylhydrazine fires produce
irritating nitrogen oxides (*NFPA 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Clayton and Clayton 1981-82)
Skin: Yes (*Clayton and Clayton 1981-82)
Ingestion: Yes (*Clayton and Clayton 1981-82)
Health Hazards (Acute, Delayed, and Chronic): Methylhydrazine vapors
are extremely toxic and the liquid is corrosive to skin. Methylhydrazine
is the strongest convulsant and the most toxic of methyl-substituted
hydrazine derivatives (*Clayton and Clayton 1981-82). It is more toxic
than hydrazine (-NFPA 1978). At high doses, it is a strong central
nervous system poison that can lead to convulsions and death (*Encyc
Occupat Health and Safety 1971)
Signs and Symptoms of Exposure: Contact may cause burns to skin and
eyes. Vapors promptly attack eyes and the respiratory system. Exposure
may also lead to central nervous system effects, such as tremors,
excitability and, at sufficiently high doses, convulsions and death
(*Encyc Occupat Health and Safety 1971).
Medical Conditions Generally Aggravated by Exposure: Skin rash may be
aggravated by skin exposure ('"'Encyc Occupat Health and Safety 1971).
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If the victim is not breathing, give artificial
respiration. If breathing is difficult, give oxygen. In addition, remove
and isolate contaminated clothing and shoes at the site. In case of
contact with the material, immediately flush skin or eyes with running
water for at least 15 minutes. Keep victim quiet and maintain normal body
temperature. Keep careful watch on victim as effects may be delayed (DOT
1984, Guide 28).
-------
CAS Registry Number: 60-34-4
Page 4 of 4
METHYLHYDRAZINE
SECTION VI -- USE INFORMATION
Used as a chemical intermediate and solvent (*ACGIH 1980). Also used as a
component of rocket propellants (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
In the case of a spill or leak, shut off ignition sources, and extinguish
or disallow flares, smoking, or flames in the hazard area. Do not touch
the spilled material, and stop leak if it can be done without risk. Use
water spray to reduce vapors. For small spills., take up the chemical with
sand or other noncombustible absorbent material and place it in containers
for later disposal. For large spills, dike far ahead for later disposal
(-DOT 1984).
-------
CAS Registry Number: 60-41-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- STRYCHNINE, SULFATE
CAS Registry Number: 60-41-3
Synonyms: (NIOSH/RTECS Synonyms 1983, Volume 3, p. 650) Strychnine,
Sulfate (2:°1); Strychnine Sulfate; Strychnidin-10-one, Sulfate (2:1)
Chemical Formula: C21H22N202» 1/2 H^S
Molecular Weight: 383.49
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: TWA for strychnine is 150 yg/ra3 (ACGIH
1984, p. 29). Toxic:
(*NIOSH/RTECS 1985).
1984, p. 29). Toxicity information: LD oral (rat) 5 mg/kg
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 392°F, 200°C with decomposition (Merck 1983, p. 1269)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g dissolves in 35 mL, 7 mL boiling water
(Merck 1983, p. 1269)
Appearance and Odor: Colorless, odorless, very bitter crystals; white
crystalline powder (Merck 1983, p. 1269).
-------
CAS Registry Number: 60-41-3
Page 2 of 3
STRYCHNINE, SULFATE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Strychnine and Salts) Small
fires: dry chemical, carbon dioxide, water spray, or foam. Large fires:
water spray, fog, or foam. Move container from fire area if you can do it
without risk (DOT 1984, Guide 53).
Special Fire Fighting Procedures: (Non-Specific -- Strychnine and
Salts) Keep unnecessary people away; isolate hazard area and deny entry.
Stay upwind; keep out of low areas. Wear self-contained (positive
pressure if available) breathing apparatus and full protective clothing
(DOT 1984, Guide 53) ..
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of sulfur oxides and nitrogen oxides (Sax 1984, p.
2473).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Protect from light (Merck 1983, p. 1269).
Incompatibility (Materials to Avoid): Alkalies, alkali carbonates and
bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric
acids, salicylates, borax, gold chloride and other alkaloid precipitants,
piperazine, potassium-mercuric iodide (Merck 1983, p. 1269).
Hazardous Decomposition or Byproducts: Emits very toxic fumes of
sulfur oxides and nitrogen oxides when heated to decomposition (Sax 1984,
p. 2473).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 60-41-3
Page 3 of 3
STRYCHNINE, SULFATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Weiss 1980, p. 1156)
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 2473)
Health Hazards (Acute, Delayed, and Chronic): Violent poison! (Merck
1983, p. 1269). Lowest published lethal dose orally in humans is 30 mg/kg
(Weiss 1980, p. 1156).
Signs and Symptoms of Exposure: (Non-Specific -- Strychnine) First
signs of poisoning are nervousness, restlessness, and twitching of
muscles, especially those in the face and neck. As condition progresses
muscular twitching becomes more pronounced and convulsions suddenly
appear. All skeletal muscles contract antagonistically; limbs are
extended and neck is curved backwards. The pupil is widely dilated.
Death results from asphyxia during a seizure or from exhaustion (Hayes
1982, p. 100).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific Strychnine) Keep
victim in a comfortably warm, quiet, and darkened room; a minor sensory
stimulus may trigger a convulsion (Gosselin 1984, p. III-377).
(Non-Specific -- Strychnine and Salts) Call emergency medical care.
Remove and isolate contaminated clothing and shoes at the site. In case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes (DOT 1984, Guide 53).
SECTION VI -- USE INFORMATION
Has been used as a tonic and stimulant in veterinary medicine (Merck 1983,
p. 1269). Registered as a rodenticide in the U.S. (USEPA/Pesticide Index
1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Strychnine and Salts) Wear self-contained (positive
pressure if available) breathing apparatus and full protective clothing.
Do not touch spilled material; stop leak if you can do it without risk.
Small spills: take up with sand or other noncombustible absorbent
material and place into containers for later disposal. Small dry spills:
with clean shovel place material into clean, dry container and cover; move
containers from spill area. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 53).
-------
CAS Registry Number: 60-51-5
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DIMETHOATE
CAS Registry Number: 60-51-5
Synonyms: 8014 Bis HC; Acetic Acid, 0,0-Dimethyldithiophosphoryl-, N-Mono-
methylamide Salt; American Cyanatnid 12,880; BI 58; CL 12880; Cygon; Cygon 4E;
Cygon Insecticide; Daphene; De-Fend; Demos-L40; Dimethogen; Dimeton; Dimevur;
ENT 24650; Experimental Insecticide 12,880; FIP; Fosfotox; Fosfotox R;
Fosfotox R 35; Fostion MM; Lurgo; NCI-C00135; 0,0-Dimethyl S-(N-Methyl-
carbamoylmethyl) Dithiophosphate; 0,0-Dimethyl S-(N-Methylcarbamoylmethyl)
Phosphorodithioate; 0,0-Dimethyl S-Methylcarbamoylmethyl Phosphorodithioate;
0,0-Dimethyldithiophosphorylacetic Acid, N-Monomethylamide Salt; PEI 75;
Perfecthion; Perfekthion; Phosphamid; Phosphamide; Phosphorodithioic Acid
0,0-Dimethyl Ester, Ester With 2-Mercapto-N-Methylacetamide; Phosphor-
odithioic Acid, 0,0-Dimethyl S-(2-(Methylamino)-2-Oxoethyl) Ester; Racusan;
Rogor; Rogor 20L; Rogor 40; Rogor L; Rogor P; Roxion; S-Methylcarbamoylmethyl
0,0-Dimethyl Phosphorodithioate; Sinoratox; Systoate
Chemical Formula: C5H12N03PS2
Molecular Weight: 229.28
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: ADI 0.02 mg/kg (*Hayes 1975). Toxicity
information: LD oral (mammal) 15 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 1.277 at 65°C (*Merck 1983)
Vapor Pressure (mmHg): 8.5 x 10"6 at 77°F (^Worthing 1979)
-------
CAS Registry Number: 60-51-5
Page 2 of 4
DIMETHOATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Melting Point: 125°F, 52°C (*Merck 1983), 113-117°F, 45-47°C for
technical product (Worthing 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 2-3 g/100 ml (*Spencer 1982)
Appearance and Odor: A white crystalline solid (*Spencer 1982) with a
camphor-like odor (''"Worthing 1979); white to greyish crystals for
technical product (Worthing 1983)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 124°F (CC) (*NFPA 1978)
Flammable Limits:
LEL: Not Found
DEL: Not 'Found
Extinguishing Methods: This material is an organophosphate insecticide
(*White-Stevens 1971; ^Worthing 1979). Methods for organophosphorus
pesticides are as follows. Small fires: dry chemical, carbon dioxide,
water spray, and foam. Large fires: water spray, fog, or foam (DOT 1984,
Guide 55).
Special Fire Fighting Procedures: Procedures for organophosphorus
pesticides are as follows. Dike fire control water for later disposal, do
not scatter the material. Wear positive pressure breathing apparatus and
protective clothing. Fight fire from maximum distance (DOT 1984, Guide
55).
Unusual Fire and Explosion Hazards: As with other organophosphorus
pesticides, container may explode in heat of fire (DOT 1984, Guide 55).
-------
CAS Registry Number: 60-51-5
Page 3 of 4
DIMETHOATE
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-Spencer 1973)
Conditions to Avoid: The temperature of storage should not exceed
70-80°F. Keep away from sources of heat, flames, or spark-generating
equipment (-Farm Chemicals Handbook 1983). Unstable in alkaline
solution. Hydrolyzed by aqueous alkali. Stable in aqueous
solutions. The compound is stable for 2 years under environmental
conditions if stored in undamaged, original containers (*Spencer 1973),
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Encyc Occupat Health and
Safety 1983)
Skin: Yes (-Encyc Occupat Health and Safety 1983)
Ingestion: Yes (*Encyc Occupat Health and
Safety 1983)
Health Hazards (Acute, Delayed, and Chronic): Very toxic; the probable
oral lethal dose in humans is between 50-500 mg/kg, or between 1 teaspoon
and 1 ounce for a 70 kg (150 Ib.) person. Dimethoate is a cholinesterase
inhibitor, meaning it affects the central nervous system. Death is due to
respiratory arrest arising from failure of respiratory center, paralysis
of respiratory muscles, intense bronchoconstriction or all three
(-Gosselin 1976).
Signs and Symptoms of Exposure: Nausea, excessive salivation,
sweating, visual disturbances, headache and fatigue are common symptoms.
A running nose and sensation of tightness in the chest are common in
inhalation exposures. In severe poisonings, loss of muscular coordination
and convulsions can occur (*Gosselin 1976; ^Morgan 1982). Difficulty in
breathing, frothing of the mouth and nose, and mental confusion may also
be noted ("''Gosselin 1976). Symptoms from dimethoate poisoning are similar
to other organophosphorus insecticides, but may develop more slowly
(*Encyc Occupat Health and Safety 1983).
-------
CAS Registry Number: 60-51-5
Page 4 of 4
DIMETHOATE
SECTION V -- HEALTH HAZARD DATA (Continued)
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Bathe and shampoo with soap and
water if there is any chance that skin and hair is contaminated ("Morgan
1982). This is an organophosphate insecticide (*White-Stevens 1971;
^Worthing 1979). First aid procedures for organophosphorus pesticides are
as follows. Move victim to fresh air; call emergency medical care. If
not breathing, give artificial respiration. If breathing is difficult,
give oxygen. In case of contact with material, immediately flush skin or
eyes with running water for at least 15 minutes. Speed in removing
material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Dimethoate is a contact and systemic organophosphate insecticide effective
against a broad range of insects and mites when applied on a wide range of
crops ("Worthing 1979; "SRI; -White-Stevens 1971). It has not been
produced in the U.S. since 1982 (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Wear rubber gloves, and to be safe, a respirator certified against toxic
vapors (*Rumack 1975 to Present). Dimethoate is an organophosphate
insecticide (*White-Stevens 1971; "Worthing 1979). Precautions for
organophosphorus pesticides include the following. Keep unnecessary
people away; isolate hazard area and deny entry. Stay upwind; keep out of
low areas. Ventilate closed spaces before entering them.. Wear positive
pressure breathing apparatus and special protective clothing. Remove and
isolate contaminated clothing at the site. Do not touch spilled material;
stop leak if you can do so without risk. Use water spray to reduce
vapors. Small spills: absorb with sand or other noncombustible absorbent
material and place into containers for later disposal. Small dry spills:
with clean shovel place material into clean, dry container and cover; move
containers from spill area. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
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CAS Registry Number: 62-38-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PHENYLMERCURY ACETATE
CAS Registry Number: 62-38-4
Synonyms: (Acetoxymercuri)Benzene; Acetic Acid, Phenylmercury Deriv;
Acetoxyphenylmercury; Agrosan GN 5; Algimycin; Antimucin WDR; Bufen; Ceresan
Universal; Contra Creme; Dyanacide; Femma; FMA; Fungitox OR; Gallotox; HL-331;
Hostaquick; Kwiksan; Leytosan; Liquiphene; Mercury(II) Acetate, Phenyl-;
Mercury, (Acetato)Phenyl-; Mersolite; Mersolite 8; Metasol 30; Norforms;
Phenmad; Phenomercuric Acetate; Phenylmercuriacetate; Phenylmercuric Acetate;
Phix; PMA; PMAC; PMacetate; PMAL; PMAS; Programin; Purasan-SC-10; Puraturf 10;
Quicksan 20; Sanitized SPG; SC-110; Shimmerex; Spor-Kil; TAG; Trigosan;
Ziarnik; Mercury,(Acetato-0)Phenyl-
Chemical Formula: C0H0Hg00
o o 2.
Molecular Weight: 336.75
SECTION I — HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.1 mg/m3 (skin) (*ACGIH 1983)
IDLH: Not Found
Other Limits Recommended: TWA air 0.05 rag (Hg)/m3. Toxicity
information: LD5Q oral (rat) 22 mg/kg (-NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): 9 x 10"6 at 35°C ('-Worthing 1979)
Melting Point: 300°F, 149°C ('''Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 62-38-4
Page 2 of 4
PHENYLMERCURY ACETATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: 1 g/180 ml (*0sol 1980); soluble in about 600
parts water (Merck 1983, p. 1052)
Appearance and Odor: White to creamy white crystalline powder or small
white prisms or leaflets. Odorless (*0sol 1980).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Above 100°F (OC) (-NFPA 1978)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Use dry chemical, foam, or carbon dioxide on
solution. Use water as necessary, but run-off should be limited and
controlled to prevent it from entering streams or water supplies (*NFPA
1978).
Special Fire Fighting Procedures: Materials are extremely hazardous to
health, but areas may be entered with extreme care. Full protective
clothing, including self-contained breathing apparatus, rubber gloves,
boots and bands around legs, arms, and waist should be provided. No skin
should be exposed (*NFPA 1978).
Unusual Fire and Explosion Hazards: Fire may produce irritating or
poisonous gases (-DOT 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Phenylmercuric ion is
incompatible with halides, with which precipitates are formed (*0sol 1980)
Hazardous Decomposition or Byproducts: When heated to decomposition,
very toxic mercuric fumes may be given off (Sax 1984, p. 100).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 62-38-4
Page 3 of 4
PHENYLMERCURY ACETATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Hawley 1977)
Skin: Yes (-Hawley 1977)
Ingestion: Yes (*Hawley 1977)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic. The
probable oral lethal dose for humans is 5-50 mg/kg, between 7 drops and 1
teaspoonful for a 70 kg (150 Ib.) person (Gosselin 1984, p. 11-137).
Signs and Symptoms of Exposure: Symptoms arising from acute exposure
may occur at varying intervals up to several weeks following exposure.
Ingestion of mercurial fungicide treated grain resulted in gastro-
intestinal irritation with nausea, vomiting, abdominal pain, and
diarrhea. Alkylmercurials produce severe neurologic toxicity, such as
loss of feeling in lips, tongue, and extremities, confusion,
hallucinations, irritability, sleep disturbances, staggering walk, memory
loss, slurred speech, auditory defects, emotional instability, and
inability to concentrate. It is also a strong skin irritant; erythema and
blistering may result 6-12 hours after exposure (^Rumack 1975 to
Present). Phenylmercury acetate, at sufficient concentration, is expected
to be injurious to the eye externally ("Grant 1974).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin and eyes with running water for at least 15
minutes. Speed in removing material from the skin is of extreme
importance. Remove and isolate contaminated clothing and shoes at the
site- Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Used as an antiseptic, fungicide, herbicide; mildewcide for paints;
slimicide in paper mills (*Hawley 1977). It was also used in
contraceptive gels and foams ("Osol 1980).
-------
CAS Registry Number: 62-38-4
Page 4 of 4
PHENYLMERCURY ACETATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Wear protective clothing and positive pressure breathing apparatus (see
Section III). Do not touch spilled material; stop leak if you can do it
without risk. Use water spray to reduce vapors. Small spills: take up
with sand or other noncombustible absorbent material and place into
containers for later disposal. Small dry spills: with clean shovel place
material into clean, dry container and cover; move containers from spill
area. Large spills: dike far ahead of spill for later disposal (*DOT
1984).
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CAS Registry Number: 62-53-3
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ANILINE
CAS Registry Number: 62-53-3
Synonyms: Aminobenzene; Aminophen; Aniline Oil; Anyvim; Benzenamine;
Benzene, Amino-; Benzidam; Blue Oil; CI 76000; CI Oxidation Base 1; Cyanol;
Krystallin; Kyanol; NCI-C03736; Phenylamine
Chemical Formula: C-H..N
o /
Molecular Weight: 93.12
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 5 ppm (19 mg/m3) (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 2 ppm (10 mg/m3) (skin); STEL 5 ppm (20 mg/m3)
(skin) (*ACGIH 1982)
IDLH: 100 ppm (NIOSH/OSHA 1978, p. 46)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 363-367°F, 184-186°C (-Merck 1976)
Specific Gravity (H 0=1): 1.022 at 20°C/20°C (*Merck 1976)
Vapor Pressure (mmHg): 0.67 at 25°C (-IARC 1972-85)
Melting Point: 21°F, -6.3°C (*Weast 1979)
Vapor Density (AIR=1): 3.22 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 gram in 28.6 mL water (-Merck 1976)
Appearance and Odor: Brown oily liquid (-Student 1981) with an
aromatic amine-like odor (-CHRIS 1978); colorless when freshly distilled
(Merck 1983, p. 96)
-------
CAS Registry Number: 62-53-3
Page 2 of 4
ANILINE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 158°F, 70°C (CC) (*NFPA 1978)
Flammable Limits:
LEL: 1.3% (*NFPA 1978)
UEL: 20-25% (*Sax 1975)
Extinguishing Methods: Use water spray, dry chemical, foam or carbon
dioxide. Use water to keep fire-exposed containers cool ("NFPA 1984).
Special Fire Fighting Procedures: Fight fire from maximum distance.
Dike fire control water for later disposal and do not scatter material
(*DOT 1984). If a leak or spill has not ignited, use water spray to
control vapors (*NFPA 1978). Wear self-contained breathing apparatus with
a full face piece operated in pressure-demand or other positive pressure
mode (-NIOSH/OSHA 1981) and special protective clothing (*DOT 1984).
Unusual Fire and Explosion Hazards: Combustion can produce toxic fumes
including nitrogen oxides and carbon monoxide ("General Electric Co. 1978,
MSDS #407). Aniline vapor forms explosive mixtures with air (*ITI 1982).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Heating (-Sax 1975)
Incompatibility (Materials to Avoid): It is incompatible with strong
oxidizers and strong acids (NIOSH/OSHA 1978, p. 46) and a number of other
materials (-Bretherick 1979; *ITI 1982; -Sax 1984).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes (*Sax 1975). These fumes may include nitrogen
oxides and carbon monoxide (General Electric Co. 1978, MSDS #407).
Hazardous Polymerization: May Occur: Yes (*IARC 1972-85)
May Not Occur:
Conditions to Avoid: Polymerizes to a resinous mass (*IARC
1972-85).
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Merck 1976)
Skin: Yes (*Merck 1976)
Ingestion: Yes (-Merck 1976)
-------
CAS Registry Number: 62-53-3
Page 3 of 4
ANILINE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): It is classified as very
toxic. Probable oral lethal dose in humans is 50-500 mg/kg for a 150 Ib.
person. Aniline poisoning is characterized by methemoglobin formation in
the blood and resulting cyanosis or blue skin ("Gosselin 1976). The
formation of methemoglobin interferes with the oxygen-carrying capacity of
the blood (Doull 1980, p. 319). The approximate minimum lethal dose for a
150 Ib. human is 10 grams ("Arena 1979). Serious poisoning may result
from ingestion of 0.25 mL ("Merck 1976).
Signs and Symptoms of Exposure: Symptoms include grayish blue skin,
headache, nausea, sometimes vomiting, dryness of throat, confusion,
vertigo, lack of muscle coordination, ringing in the ears, weakness,
disorientation, lethargy, drowsiness and coma. Urinary signs include
painful urinating, blood in the urine, the presence of hemoglobin in the
urine, and diminished amounts of urine ("Gosselin 1976). Chronic exposure
can cause anemia, anorexia, weight loss, and skin lesions (*Merck 1976).
Medical Conditions Generally Aggravated by Exposure: People at special
risk include individuals with glucose-6-phosphate-dehydrogenase deficiency
(*Arena 1979) and those with liver and kidney disorders, blood diseases,
or a history of alcoholism (-General Electric Co. 1978, MSDS #407).
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material is of extreme importance. Remove and
isolate contaminated clothing. Keep victim quiet and maintain normal body
temperature. Effects may be delayed, keep victim under observation (*DOT
1984).
SECTION VI -- USE INFORMATION
Manufacture of dyes, resins, varnishes, perfumes, shoe blacks, vulcanizing
rubber; solvent (*Merck 1976); inks, paint removers ("Dreisbach 1977);
herbicides, fungicides, explosives, photographic chemicals ("Hawley 1977);
isocyanates (*SRI); and rigid polyurethanes (*NIOSH/OSHA 1981). It is a
chemical intermediate for dyes and pigments and a number of other
materials (*SRI).
-------
CAS Registry Number: 62-53-3
Page 4 of 4
ANILINE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Wear positive pressure breathing apparatus and special protective
clothing. Shut off ignition sources; no flares, smoking or flames in
hazard area. Do not touch spilled material; stop leak if you can do it
without risk. Use water spray to reduce vapors. Small spills: take up
with sand or other non-combustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (-DOT 1984).
-------
CAS Registry Number: 62-73-7
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- DICHLORVOS
CAS Registry Number: 62-73-7
Synonyms: 0,0-Dimethyl 0-2,2-Dichlorovinyl Phosphate; 2,2-Dichloroethenyl
Phosphoric Acid Dimethyl Ester; 2,2-Dichlorovinyl Dimethyl Phosphate; Atgard;
Bay-19149; Bibesol; Brevinyl; Brevinyl E50; Canogard; Cekusan; Chlorvinphos;
Cyanophos; DDVF; DDVP; DEDEVAP; Deriban; Derribante; Dichlorman; Dichlorovas;
Dichlorovos; Dichlorphos; Dimethyl 2,2-Dichloroethenyl Phosphate; Dimethyl
2,2-Dichlorovinyl Phosphate; Divipan; ENT 20738; Equigard; Equigel; Estrosel;
Ethenol, 2,2-Dichloro-, Dimethyl Phosphate; Fecama; Herkal; Herkol; Krecalvin;
Mafu; Marvex; NCI-C00113; Nerkol; No-Pest Strip; Nogos; Nuva; 0,0-Dimethyl
Dichlorovinyl Phosphate; QMS 14; Phosphoric Acid, 2,2-Dichlorovinyl Dimethyl
Ester; Phosphoric Acid, 2,2-Dichloroethenyl Dimethyl Ester; Phosvit;
Szklarniak; Task; Vapona; Vaponite; 2,2-Dichloroethenyl phosphate; Atgard V;
Brevinyl Weedat 0002; Celcusan; Dichlorophos; Dimethyl dichlorovinyl
phosphate; Nuvan 100 EC; Unifos; Vapona insecticide; Astrobot; Estrosol;
Nuvan; SD1750; Fly fighter; Fly-die; Mopari UN NA 2783; Nogos 50; Nogos G;
NSC-6738; OKO; Tap 9vp; Task Tabs; Tenac; UDVF; Unifos 50 EC; Vapona II;
Verdican; Verdipor; Vinyl alcohol, 2,2-Dichloro-, Dimethyl Phosphate;
Vinylophos
Chemical Formula: C^Cl O.P
Molecular Weight: 220.98
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 1 mg/m3 (skin) (NIOSH/OSHA 1978, p. 84)
ACGIH TLV: TWA 0.1 ppm, 1 mg/m3; STEL 0.3 ppm, 3 mg/m3 (*AGGIH
1980)
IDLH: 200 mg/m3 (NIOSH/OSHA 1978, p. 84)
Other Limits Recommended: Not Found
-------
CAS Registry Number: 62-73-7
Page 2 of 4
DICHLORVOS
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 284°F, 140°C at 20 mmHg (*Merck 1976)
Specific Gravity (H20=l): 1.415 at 25°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 0.01 at 30°C (*Sunshine 1969)
Melting-Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Approximately 1 g/100 ml (*Merck 1976)
Appearance and Odor: Oily colorless to amber liquid with an aromatic
chemical odor (-Patty 1963; *NIOSH/OSHA 1981)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Greater than 175°F (no method given) (*NFPA
1978)
Flammable Limits: Moderately flammable (NIOSH/OSHA 1978, p. 84); will
not ignite easily (-DOT 1984)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Water in flooding quantities as fog, alcohol
foam, dry chemical, or carbon dioxide (NIOSH/OSHA 1978, p. 84). Do not
scatter the material (-DOT 1984).
Special Fire Fighting Procedures: Use self-contained breathing
apparatus with a full face piece operated on pressure-demand or other
positive pressure mode. Prevent skin contact with protective clothing
(*NIOSH/OSHA 1978). Isolate area and deny entry. Fight fire from maximum
distance. Dike fire control water for future disposal (*DOT 1984).
Unusual Fire and Explosion Hazards: Highly toxic chloride fumes or
phosgene may be released when this product burns. Firefighters should
take precautions noted above (*Sax 1979).
-------
CAS Registry Number: 62-73-7
Page 3 of 4
DICHLORVOS
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Encyc Occupat Health and Safety 1971)
Stable:
Conditions to Avoid: Hydrolyzes in water (*Sunshine 1969).
Incompatibility (Materials to Avoid): Corrosive to iron and mild steel
(^Worthing 1979); acids or acid fumes (*Sax 1979).
Hazardous Decomposition or Byproducts: Toxic chloride fumes and
phosgene formed if heated to decomposition or on contact with acid or acid
fumes (*Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Yes (*DOT 1984)
Ingestion: Yes (-DOT 1984)
Health Hazards (Acute, Delayed, and Chronic): Dichlorvos is a very
toxic compound with a probable lethal oral dose in humans between 50 and
500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 Ib.)
person. However, brief exposure (30-60 minutes) to vapor concentrations
as high as 6.9 yg/liter did not result in clinical signs or depressed
serum cholinesterase levels. Toxic changes are typical of organophosphate
insecticide poisoning with progression to respiratory distress,
respiratory paralysis, and death if there is no clinical intervention
(Gosselin 1984, pp. 11-291 and III-336, 337).
Signs and Symptoms of Exposure: Sweating, twitching, contracted
pupils, respiratory distress (tightness in the chest and wheezing),
salivation (drooling), lacrimation (tearing), nausea, vomiting, abdominal
cramps, diarrhea, involuntary defecation and urination, slurred speech,
coma, apnea (cessation of breathing), and death (Doull 1980, pp. 367-368).
Medical Conditions Generally Aggravated by Exposure: Not Found
-------
CAS Registry Number: 62-73-7
Page 4 of 4
DICHLORVOS
SECTION V -- HEALTH HAZARD DATA (Continued)
Emergency and First Aid Procedures: Call emergency medical care. If
victim was exposed by inhalation, move to fresh air. If not breathing,
give artificial respiration; if breathing is difficult, give oxygen. If
exposure was by contact, flush skin or eyes with running water for at
least 15 minutes; it is critical to remove the material from the skin as
quickly as possible. Also remove contaminated clothing and shoes. Victim
should be kept quiet, warm, and observed for delayed effects (*DOT 1984).
SECTION VI -- USE INFORMATION
Agricultural insecticide for use on crops, stored products, animals, and
premises; insecticide for slow release on pest-strips for pest control in
homes and aircraft; anthelmintic for dogs, swine, and horses; botacide for
horses; flea collars for dogs ("Gosselin 1976; *Rossoff 1974; ^Worthing
1979; -SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Prevent access to area from public by isolating area and denying entry.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus, goggles, and special protective clothing. Remove and
isolate contaminated clothing at the site. Do not touch spilled material;
stop leaks if you can do it without risk. Reduce vapors with water
spray. Take up small spills with sand or other noncombustible absorbent
material for later disposal in cannisters. Dike large spills far ahead of
spill for later disposal (-DOT 1984).
-------
CAS Registry Number: 62-74-8
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- SODIUM FLUOROACETATE
CAS Registry Number: 62-74-8
Synonyms: Acetic Acid, Fluoro-, Sodium Salt; 1080; Compd 1080; Compound
No. 1080J Fluoroacetic Acid, Sodium Salt; Fratol; Furatol; Ratbane 1080; SMFA;
Sodium Fiuoacetate; Sodium Fluoacetic Acid; Sodium Fluoracetate; Sodium
Monofluofoacetate; Ten-Eighty; TL 869; Yasoknock
Chemical Formula: C H FO Na
Molecular Weight: 100.02
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 0.05 mg/m3 (skin) (-NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.05 mg/m3 (skin); STEL 0.15 mg/m3 (skin) (*ACGIH
1983)
IDLH: 5 mg/m3 (NIOSH/OSHA 1978, p. 166)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): 0.0 at 20°C (*ACGIH 1980)
Melting Point: 392°F, 200°C (*Weast 1979); decomposes at 392°F, 200°C
(-Hawley 1981)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1110 g/liter at 25°C («Weast 1979)
-------
CAS Registry Number: 62-74-8
Page 2 of 3
SODIUM FLUOROACETATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: White powder (*Weast 1979); odorless (*Hawley
1981). Usually marketed as water solution containing 0.5 percent
Nigrosine as black warning color (*Spencer 1982).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Not combustible (NIOSH/OSHA 1978, p. 166)
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Use dry chemical, carbon dioxide, water spray,
or foam. For large fires, use water spray, fog, or foam (*DOT 1984).
Special Fire Fighting Procedures: Stay upwind; keep out of low areas.
Wear self-contained, positive pressure breathing apparatus and full
protective clothing (*DOT 1984).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits highly toxic fumes of sodium oxide and fluorides (*Sax 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-NIOSH/OSHA 1978)
Conditions to Avoid: Decomposing heat (*Sax 1984)
Incompatibility (Materials to Avoid): None hazardous (NIOSH/OSHA 1978,
p. 166)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits fumes of sodium oxide and fluorides (*Sax 1984).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 62-74-8
Page 3 of 3
SODIUM FLUOROACETATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (-Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): This material is super
toxic. The probable oral lethal dose in humans is less than 5 mg/kg, or a
taste (less than 7 drops) for a 150-lb. person (*Gosselin 1976).
Signs and Symptoms of Exposure: Symptoms include nausea, vomiting,
diarrhea, hyperactive behavior, convulsions, coma, and ventricular
fibrillation. Symptoms are usually seen within one-half hour of exposure,
but severe effects may be delayed as long as 20 hours (*Rumack 1975 to
Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: There is no known specific
treatment for fluoroacetate exposure, but generally symptomatic support
should be provided (*Rumack 1975 to Present). Move victim to fresh air.
Call emergency medical care. Remove and isolate contaminated clothing and
shoes at the site. In case of contact with material, immediately flush
skin or eyes with running water for at least 15 minutes ('VDOT 1984).
SECTION VI -- USE INFORMATION
This material is used for control of predatory animals, coyotes, and
rodents (*Farm Chemicals Handbook 1984).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material. Stay upwind; keep out of low areas. Wear
self-contained, positive pressure breathing apparatus and full protective
clothing (*DOT 1984).
-------
CAS Registry Number: 62-75-9
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- NITROSODIMETHYLAMINE
CAS Registry Number: 62-75-9
Synonyms: N-Nitrosodimethylamine; Dimethyl Nitrosamine; Dimethylamine,
N-Nitroso-; Dimethylnitrosamine; Dimethylnitrosoamine; DMN; DMNA; Methanamine,
N-Methyl-N-Nitroso-; N,N-Dimethylnitrosamine; N-Methyl-N-Nitrosomethanamine;
N-Nitroso-N,N-Dimethylamine; NDMA
Chemical Formula: C0H,N00
/ b /
Molecular Weight: 74.08
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA and STEL: Industrial substance suspected of
carcinogenic potential in humans (*ACGIH 1984)
IDLH: Not Found
Other Limits Recommended: Exposures should be avoided, in so far as
possible or otherwise be kept to an absolute minimum; suspected of
carcinogenic potential in humans (*ACGIH 1984). Toxicity information:
LC, inhalation (dog) 0.048 mg/liter/4 hours (*NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 304-307°F, 151-153°C (*Merck 1983)
Specific Gravity (H20=l): 1.0048 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 62-75-9
Page 2 of 3
NITROSODIMETHYLAMINE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Very soluble (-Merck 1983)
Appearance and Odor: Yellow oily liquid (*IARC 1972-1985); faint
characteristic odor ("Clayton and Clayton 1982)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Clayton and Clayton 1981, p. 3119)
Conditions to Avoid: Exposure to ultraviolet light (Clayton and
Clayton 1981, p. 3119).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of nitrogen oxides (Sax 1984, pp. 1180-1181).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (^Sunshine 1969)
Skin: Yes (^Sunshine 1969)
Ingestion: Yes ("Sunshine 1969)
-------
CAS Registry Number: 62-75-9
Page 3 of 3
NITROSODIMETHYLAMINE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Extremely high toxicity
(''•Sunshine 1969). It is a suspected human carcinogen. The lowest lethal
oral dose in humans has been reported at 10 mg/kg/80 week intermittent
exposure (*NIOSH/RTECS 1985).
Signs and Symptoms of Exposure: Symptoms include nausea, vomiting and
malaise=(*Cooper 1980). Chronic exposure may cause liver disease with
jaundice and swelling (^Hamilton 1984) with low platelet count (*Cooper
1980).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Establish respiration; prevent
absorption; decontaminate with soap and water; for eye exposure, flush
with water ("Rumack 1975 to Present). (Poisonous Liquid or Gas, n.o.s.)
Move victim to fresh air; call emergency medical care. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen.
Remove and isolate contaminated clothing and shoes at the site. In case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Keep victim quiet and maintain normal body
temperature. Effects may be delayed; keep victim under observation (DOT
1984, Guide 15).
SECTION VI -- USE INFORMATION
Dimethylnitrosamine was formerly used in the production of rocket fuels.
Presently used as an antioxidant, as an additive for lubricants and as a
softner of copolymers (Merck 1983, p. 952). It is an intermediate for
1,1-dimethyIhydrazine (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact (see Section V above). Spills can be
absorbed by celite or commercial spill absorbent. After absorbent
containing major share of nitrosamine has been picked-up (avoid dusts; do
not sweep), surface should be thoroughly cleaned with strong detergent
solution. If major spill occurs outside of ventilated area, room should
be evacuated and cleanup operation should be carried out by persons
equipped with self-contained breathing apparatus. Those involved should
wear rubber gloves, lab coats and plastic aprons or equivalent protective
apparel (*NRC 1981).
-------
CAS Registry Number: 64-00-6
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PHENOL, 3-(1-METHYLETHYL)-, METHYLCARBAMATE
CAS Registry Number: 64-00-6
Synonyms (NIOSH/RTECS, 1983, Volume I, p. 832): Carbamic Acid, Methyl-,
m-Cumenyl Ester; Carbamic Acid, N-Methyl-, 3-Isopropylphenyl Ester; Compound
10854; m-Cumenol Methylcarbamate; m-Cumenyl Methylcarbamate; ENT 25,500; ENT
25,543; H 5727; H 8757; HER. 5727; Hercules 5727; Hercules AC 5727; HIP;
m-Isopropylphenol N-Methylcarbamate; m-Isopropylphenyl Methylcarbamate;
m-Isopropylphenyl N-Methylcarbamate; 3-Isopropylphenyl Methylcarbamate;
N-Methyl m-Isopropylphenyl Carbamate; N-Methyl 3-Isopropylphenyl Carbamate;
QMS 162; 1PC; Phenol, m-Isopropyl-, Methylcarbamate; UC 10854; Union Carbide
10854; Union Carbide UC-10,854
Chemical Formula: ci1H15N02
Molecular Weight: 193.27
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD n oral (guinea
pig) 10 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 162-165°F, 72-74°C (Hayes 1982, p. 450)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 64-00-6
Page 2 of 4
PHENOL, 3-(1-METHYLETHYL)-, METHYLCARBAMATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: 85 ppm at 30°C (Hayes 1982, p. 450)
Appearance and Odor: Pure white solid without appreciable odor (Hayes
1982, p. 450).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Carbamate Pesticide, Solid,
n.o.s.) Extinguish with dry chemical, carbon dioxide, water spray, fog,
or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Carbamate
Pesticide, Solid, n.o.s.) Wear positive pressure breathing apparatus and
special protective clothing. Move container from fire area if you can do
it without risk. Dike fire control water for later disposal; do not
scatter the material. Fight fire from maximum distance (DOT 1984, Guide
55).
Unusual Fire and Explosion Hazards: (Non-Specific -- Carbamate
Pesticide, Solid, n.o.s.) Container may explode in heat of fire (DOT
1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Hayes 1982, p. 450)
Conditions to Avoid: Decomposing heat (Sax 1984, p. 820)
Incompatibility (Materials to Avoid): Incompatible with alkalis (Hayes
1982, p. 450).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of nitrogen oxides (Sax 1984, p. 820).
-------
CAS Registry Number: 64-00-6
Page 3 of 4
PHENOL, 3-d-METHYLETHYL)-, METHYLCARBAMATE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Non-Specific -- Carbamate Pesticide,
Solid, n.o.s.) (DOT 1984, Guide 55)
Skin: Yes (Sax 1984, p. 820)
Ingestion: Yes (Sax 1984, p. 820)
Health Hazards (Acute, Delayed, and Chronic): It is a cholinesterase
inhibitor (Hayes 1982, p. 450).
Signs and Symptoms of Exposure: Exposure may result in weakness,
dizziness, tightness in the chest, headache, pinpoint pupils, profuse
sweating, blurred vision, stomach pain, vomiting, skin rashes, and
giddiness (Hayes 1982, p. 451).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Carbamate
Pesticide, Solid, n.o.s.) Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
It is used as an insecticide to protect cotton, fruit, vegetables and
field crops (Farm Chemicals Handbook 1984, p. C-236). Not registered as a
pesticide in the U.S. (USEPA/Pesticide Index 1985).
-------
CAS Registry Number: 64-00-6
Page 4 of 4
PHENOL, 3-(l-METHYI_ETHYL)-, METHYLCARBAMATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Carbamate Pesticide, Solid, n.o.s.) When handling, wear
self-contained breathing aparatus and full protective clothing (i.e.,
boots, gloves, and goggles). Keep unnecessary people away and stay
upwind. Do not touch the material or handle broken packages without
protective clothing. Use water spray to reduce vapors. Take up spills
with non-combustible absorbent material. For small dry spills, place
material in a clean dry container with a clean shovel and cover; remove
from site of spill. For large spills dike far ahead for later disposal
(DOT 1984, Guide 55; Student 1981, p. 104).
COMMENTS:
Sources searched but no information found:
Weiss 1980
Buchel 1983
Gosselin 1984
Merck 1983
Weast 1979
-------
CAS Registry Number: 64-86-8
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- COLCHICINE
CAS Registry Number: 64-86-8
Synonyms: 7-alpha-H-Colchicine; Acetamide, N-(5,6,7,9-Tetrahydro-l,2,3,10-
Tetramethoxy-9-oxobenzo[a]heptalen-7-y1); Benzo[a]heptalen-9(5H)-one,
7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-; Colchicenos; Colchisol;
Colcin; Colsaloid; Condylon; N-Acetyl Trimethylcolchicinic acid, Methyl Ether;
NSC 757
Chemical Formula: C0.H.-NO,
// /-> O
Molecular Weight: 399.43
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: ID. oral (dog,
cat) 0.125 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 288-302°F, 142-150°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g dissolves in 22 ml (*Merck 1976)
-------
CAS Registry Number: 64-86-8
Page 2 of 3
COLCHICINE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Odorless or nearly so (*Hawley 1977); pale yellow
needles or powder; darkens on exposure to light (*Merck 1976).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods:. Slight fire potential (*Sax 1979). Material is
a drug (*SRI), with the following procedures for fires. Extinguish fire
using agent suitable for type of surrounding fire. Use water in flooding
quantities as fog. Use alcohol foam, carbon dioxide or dry chemical
(Student 1981, p. 215).
Special Fire Fighting Procedures: For drugs, solid, n.o.s., avoid
breathing dusts and fumes from burning material. Keep upwind. Wear
boots, protective gloves, and goggles (Student 1981, p. 215).
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-Clarke 1975)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (*Gosselin 1976)
-------
CAS Registry Number: 64-86-8
Page 3 of 3
COLCHICINE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
super toxic. Probable oral lethal dose in humans is less than 5 mg/kg,
i.e. less than 7 drops for a 70 kg (150 Ib.) person (*Gosselin 1976).
Death results from respiratory arrest. The fatal dose varies
considerably; as little as 7 mg of colchicine has proved fatal (*Goodman
1975).
Signs and Symptoms of Exposure: Burning of throat and skin are
prominent symptoms. Nausea, vomiting, diarrhea and abdominal pain may
occur several hours after exposure. Shock occurs because of extensive
vascular damage. Kidney damage resulting in bloody urine and diminished
urine output may occur (*Goodman 1975).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: This material is an alkaloid
(Merck 1983, p. 352); first aid for alkaloid exposure is as follows: move
victim to fresh air; call emergency medical care. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. In case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Speed in removing material from skin is of
extreme importance. Remove and isolate contaminated clothing and shoes at
the site. Keep victim quiet and maintain normal body temperature.
Effects may be delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Colchicine is a drug used to treat gouty arthritis, pseudogout, sarcoidal
arthritis and calcific tendinitis (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Precautions for drugs, solid, n.o.s., include the following. Avoid
breathing dusts, and fumes from burning materials. Keep upwind. Wear
self-contained breathing apparatus. Avoid bodily contact with the
material. Wear full protective clothing. Wash away any material which
may have contacted the body with copious amounts of water or soap and
water (Student 1981, p. 215).
-------
CAS Registry Number: 65-30-5
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY - NICOTINE SULFATE
CAS Registry Number: 65-30-5
Synonyms: (S)-3-(l-Methyl-2-Pyrrolidinyl)Pyridine Sulfate (2:1); L-l-
Methyl-2-(3-Pyridyl)-Pyrrolidine Sulfate; L-3-(l-Methyl-2-Pyrrolidyl)Pyridine
Sulfate; Black Leaf 40; Nicotine Sulfate, Solid; Nicotine, Sulfate (2:1);
Pyridine, 3-(l-Methyl-2-Pyrrolidinyl)-, (S)-, Sulfate (2:1); Pyrrolidine,
l-Methyl-2-(3-Pyridyl)-, Sulfate
Chemical Formula: (C10H14N2)2*H2S04
Molecular Weight: 422.56
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.5 mg (nicotine)/m3; STEL 1.5 mg (nicotine)/mj
(skin) (*ACGIH 1982)
IDLH: Not Found
Other Limits Recommended: TWA for nicotine: 0.5 mg/m3 (skin) (OSHA
1984, p. 663). Tox:
(*NIOSH/RTECS 1985)
1984, p. 663). Toxicity information: LD,_ oral (mice) 8.55 mg/kg
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 1.15 at 20°C (solid) (*CHRIS 1978)
Vapor Pressure (tnmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in water (*Merck 1976)
-------
CAS Registry Number: 65-30-5
Page 2 of 4
NICOTINE SULFATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: A six-sided tablet (*Merck 1976) or white
crystals; (40% solution = Black Leaf Forty) (Hawley 1981, p. 727). No
odor information.
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: As for nicotine, extinguish with alcohol foam,
dry chemical, or carbon dioxide (Sax 1984, p. 1997). Large fires can be
extinguished with water spray, fog, or foam (*DOT 1984).
Special Fire Fighting Procedures: Wear positive pressure breathing
apparatus and special protective clothing. Dike fire control water; do
not scatter the material (*DOT 1984).
Unusual Fire and Explosion Hazards: As for nicotine, moderate
explosion hazard when exposed to heat or flame (*Sax 1975).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Menzie 1969)
Conditions to Avoid: Decomposing heat (Sax 1984, p. 1998)
Incompatibility (Materials to Avoid): (Non-Specific -- Nicotine)
Avoid oxidizing materials (Sax 1984, p. 1997).
Hazardous Decomposition or Byproducts: When heated to decomposition,
emits highly toxic fumes of sulfur oxides and organic fumes (Sax 1984, p.
1998).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 65-30-5
Page 3 of 4
NICOTINE SULFATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
super toxic. Probable oral lethal dose in humans is less than 5 mg/kg
(less than 7 drops) for a 70 kg (150 Ib.) person (*Gosselin 1976). Death
is possible from respiratory failure caused by paralysis of the
respiratory muscles (*Goodman 1980).
Signs and Symptoms of Exposure: Onset of acute poisoning is rapid.
Symptoms include nausea, salivation, abdominal pain, vomiting, diarrhea,
cold sweat, headache, dizziness, disturbed hearing and vision, mental
confusion, marked weakness, faintness and prostration, lowered blood
pressure, difficult breathing, and weak, rapid and irregular pulse
(*Goodman 1980). Inhalation irritates nose and throat. The liquid form
irritates the eyes and (on prolonged contact) skin (*CHRIS 1978).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim under observation (-DOT 1984).
SECTION VI -- USE INFORMATION
It is used as an insecticide ("Merck 1976) and in veterinary medicine as
an anthelmintic and external parasiticide (''"Garner 1967).
-------
CAS Registry Number: 65-30-5
Page 4 of 4
NICOTINE SULFATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Full personal protective equipment should be worn (i.e., dust respirator
and special protective clothing ) (*CHRIS 1978). To clean up, do not
touch spilled material; stop leak if possible. Use water spray to reduce
vapors. Wear positive pressure breathing apparatus and special protective
clothing. Small spills: take up with sand or other noncombustible
absorbent material and place into containers for disposal. Small dry
spill: with clean shovel place material into clean, dry container and
cover; move containers from spill area. Large spills: dike far ahead of
spill for later disposal (*DOT 1984).
-------
CAS Registry Number: 65-86-1
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- OROTIC ACID
CAS Registry Number: 65-86-1
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 896)
6-Carboxyuracil; Animal Galactose Factor; Orodin; Orotonin; Orotoric; Orotyl;
4-Pyrimidinecarboxylic Acid, l,2,3,6-Tetrahydro-2,6-Dioxo-(9CI);
6-Uracilcarboxylic Acid; Whey Factor
Chemical Formula: CCH.N-0.
5424
Molecular Weight: 156.11
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (mouse) 2
mg/kg (*NIOSH/RTECS 1985) (SUSPECT)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 653-655°F, 345-346°C (Hawley 1981, p. 763)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (Weast 1980, p. C-536)
Appearance and Odor: Crystals (Hawley 1981, p. 763)
-------
CAS Registry Number: 65-86-1
Page 2 of 3
OROTIC ACID
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Not Found
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Not Found
-------
CAS Registry Number: 65-86-1
Page 3 of 3
OROTIC ACID
SECTION VI -- USE INFORMATION
Used in biochemical research, especially in the biosynthesis of nucleic
acids (Hawley 1981, p. 763). Has been proposed as a feed supplement
(Merck 1983, p. 986).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Not Found
COMMENTS
Sources checked but no information found:
Sax 1984
Student 1981
NFPA 1984
DOT 1984
Weiss 1980
Clayton and Clayton 1981-82
Gosselin 1984
Encyc Occupat Health and Safety 1983
ACGIH 1983
NIOSH/OSHA 1978
-------
CAS Registry Number: 66-81-9
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CYCLOHEXIMIDE
CAS Registry Number: 66-81-9
Synonyms: Glutarimide, 3-(2-(3,5-Dimethyl-2-Oxocyclohexyl)-2-
Hydroxyethyl)-; 2,6-Piperidinedione, 4-(2-(3,5-Dimethyl-2-Oxocyclohexyl)-
2-Hydroxyethyl)- (1S-(1 alpha(S*), 3 alpha, 5 beta))-; Acti-aid; Acti-Dione-PM
(-RZ, -BR, & -S); Actidion; Actidione; Actidione PM; Actispray; beta-(2-(3,5-
Dimethyl-2-Oxocyclohexyl)-2-Hydroxyethyl)Glutarimide; Hizarocin; Kaken;
Naramycin; Naramycin A; Neocycloheximide; NSC-185; TZA; U 4527
Chemical Formula: C H. N04
Molecular Weight: 281.34
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD,.,. oral (rat)
2 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 247-250°F, 119.5-121°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 66-81-9
Page 2 of 3
CYCLOHEXIMIDE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Moderately soluble (Sax 1984, p. 833); 21 g/liter
at 36°F, 2°C (*Merck 1976)
Appearance and Odor: Colorless crystals (^Spencer 1973). Odor not
found.
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Fungicides, Poison B Solid)
Use agent suitable for surrounding fire. Use alcohol foam, carbon
dioxide, or dry chemical. Use water in flooding quantities as fog
(Student 1981, p. 259).
Special Fire Fighting Procedures: (Non-Specific -- Fungicides, Poison
B Solid) Avoid breathing dusts and fumes from burning material. Keep
upwind. Wear self-contained breathing apparatus. Avoid bodily contact
with the material. Wear full protective clothing (Student 1981, p. 259).
Unusual Fire and Explosion Hazards: When exposed to heat, it emits
toxic fumes, including nitrogen oxides (Sax 1984, p. 833).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (''-Merck 1976)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When exposed to heat, it emits
toxic fumes, including nitrogen oxides (Sax 1984, p. 833).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 66-81-9
Page 3 of 3
CYCLOHEXIMIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes ("Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): This material is
extremely toxic; the probable oral lethal dose in humans is 5-50 mg/kg, or
7 drops to 1 teaspoonful for a 150-lb. person ("'Gosselin 1976).
Signs and Symptoms of Exposure: Symptoms include nausea, vomiting, and
elevated blood urea nitrogen. Signs of skin irritation may appear as much
as 6 to 24 hours after exposure (*Rumack 1975 to Present)
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: In case of skin contact, wash with
soap, followed by alcohol, followed by a second soap washing. In case of
eye contact, rinse eyes with copious amounts of water for at least 15
minutes ("Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
This material is used as a fungicide (*Merck 1976), and as a medication in
cancer therapy (*Rumack 1975 to Present).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Fungicides, Poison B Solid) Avoid breathing dusts. Keep
upwind. Wear self-contained breathing apparatus. Avoid bodily contact
with the material. Wear full protective clothing (Student 1981, p. 259).
Material is rapidly inactivated at room temperature by dilute alkali
(-Merck 1976).
-------
CAS Registry Number: 67-66-3
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CHLOROFORM
CAS Registry Number: 67-66-3
Synonyms: Formyl Trichloride; Freon 20; Methane, Trichloro-; Methane
Trichloride; Methenyl Chloride; Methenyl Trichloride; Methyl Trichloride;
NCI-C02686; R-20; R 20 (Refrigerant); TCM; Trichloroform; Trichloromethane
Chemical Formula: CHC1
Molecular Weight: 119.39
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 50 ppm (ceiling) (OSHA 1984, p. 661)
ACGIH TLV: TWA 10 ppm (50 mg/m3); STEL 50 ppm (225 mg/m3) (*ACGIH
1985)
IDLH: 1,000 ppm (NIOSH/OSHA 1978, p. 68)
Other Limits Recommended: Industrial substance suspect of carcinogenic
potential for humans (ACGIH 1985, p. 42).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 143°F, 61.7°C (*Weast 1979)
{2
Specific Gravity (H.0=l): 1.4832 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): 100 at 10.4°C (*Sax 1979)
Melting Point: -82.3°F, -63.5°C (*Weast 1979)
Vapor Density (AIR=1): 4.12 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): (Carbon Tetrachloride = 1) 1.18
(^General Electric Co. 1979, MSDS #315)
Solubility in Water: 1 mL/200 mL at 25°C (*Merck 1976)
Appearance and Odor: A clear, colorless and mobile liquid with a
characteristic odor (*IARC 1972-1985).
-------
CAS Registry Number: 67-66-3
Page 2 of 4
CHLOROFORM
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): None (*General Electric Co. 1979, MSDS #315)
Flammable Limits:
LEL: None ('^General Electric Co. 1979, MSDS #315)
UEL: None (^General Electric Co. 1979, MSDS #315)
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog or foam (*DOT 1984).
Special Fire Fighting Procedures: Wear self-contained breathing
apparatus and special protective clothing. Move container from fire
area. Fight fire from maximum distance. Dike fire control water for
later disposal; do not scatter the material (*DOT 1984).
Unusual Fire and Explosion Hazards: Container may explode in the heat
of fire (-DOT 1984). When heated it liberates phosgene (*ITI 1982);
hydrogen chloride, chlorine and toxic and corrosive oxides of carbon and
chlorine ('-General Electric Co. 1979, MSDS #315).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*CHRIS 1978)
Conditions to Avoid: It develops acidity from prolonged exposure
to air and light (^General Electric Co. 1979, MSDS #315).
Incompatibility (Materials to Avoid): Chloroform explodes when in
contact with aluminum powder or magnesium powder or with alkali metals
(e.g., lithium, sodium, and potassium) (*NFPA 1978) and dinitrogen
tetroxide. It reacts vigorously with acetone in the presence of potassium
hydroxide or calcium hydroxide (*Bretherick 1975). It is oxidized by
strong oxidizers such as chromic acid forming phosgene and chlorine (*IARC
1972-1985). It reacts vigorously with triisopropylphosphine (*Bretherick
1975).
Hazardous Decomposition or Byproducts: When heated, it emits hydrogen
chloride, chlorine, toxic and corrosive oxides of carbon and chlorine
(-General Electric Co. 1979, MSDS #315) and phosgene (*ITI 1982).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 67-66-3
Page 3 of 4
CHLOROFORM
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*NIOSH 1974)
Skin: Yes (*DOT 1984)
Ingestion: Yes (*ITI 1982)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
moderately toxic. Probable oral lethal dose for humans is 0.5 to 5 g/kg
(between 1 ounce and 1 pint) for a 150 Ib. person. The mean lethal dose
is probably near 1 fluid ounce (44 g) ("Gosselin 1976). It is a human
suspected carcinogen (*IARC 1972-1985). Also, it is a central nervous
system depressant and a gastrointestinal irritant (*Challen PS et al.
1958. Br J Ind Med 15:243). It has caused rapid death attributable to
cardiac arrest and delayed death from liver and kidney damage (*IARC
1972-1985).
Sighs and Symptoms of Exposure: Symptoms of acute exposure include
fainting sensation, vomiting, dizziness, salivation, nausea, fatigue, and
headache ("ACGIH 1971-1979). Other symptoms are respiratory depression,
coma, kidney damage, and liver damage ("IARC 1972-1985). Liquid in the
eye causes tearing and conjunctivitis ("Grant 1974). Symptoms of chronic
exposure include loss of appetite, hallucinations, moodiness and physical
and mental sluggishness ("NIOSH 1974. Criteria for a recommended standard
occupational exposure to chloroform. DHEW Pub NIOSH 75-114).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove, and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation ("DOT 1984).
SECTION VI -- USE INFORMATION
It is used as a grain fumigant; solvent for pesticides, adhesives (*IARC
1972-1985) fats, oils, rubbers, alkaloids, waxes (*Merck 1976); chemical
intermediate for dyes and pesticides; and a component of cough syrups,
toothpastes, and linaments (*SRI). Not registered as a pesticide in the
U.S. (USEPA/Pesticide Index 1985).
-------
CAS Registry Number: 67-66-3
Page 4 of 4
CHLOROFORM
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Wear positive pressure breathing apparatus and special protective
clothing. Remove and isolate contaminated clothing at the site. Do not
touch spilled material; stop leak if you can do it without risk. Use
water spray to reduce vapors. Small spills: take up with sand or other
non-combustible absorbent materal and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal (*DOT
1984).
-------
CAS Registry Number: 71-63-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DIGITOXIN
CAS Registry Number: 71-63-6
Synonyms: Acedoxin; Card-20(22)-Enolide, 3-((0-2,6-Dideoxy-beta-D-Ribo-
Hexopyranosyl-(Hexopyranosyl-(l-4)-2,6-Dideoxy-beta-D-Ribo-Hexopyranosyl)oxy)
-14-Hydroxy-, (3beta, Sbeta)-; Cardigin; Carditoxin; Cristapurat; Crystalline
Digitaliri; Crystodigin; Digilong; Digimed; Digimerck; Digisidin; Digitalin;
Digitaline Cristallisee; Digitaline Nativelle; Digitoksim; Digitophyllin;
Digitoxigenin Tridigitoxoside; Ditaven; Glucodigin; Lanatoxin; Myodigin;
Purodigin; Purpurid; Unidigin
Chemical Formula: C-.H-.O,,
41 64 13
Molecular Weight: 764.92
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (cat)
0.18 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 493-495°F, 256-257°C (when anhydrous) (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g in 100 liters at 20°C (*Merck 1976)
-------
CAS Registry Number: 71-63-6
Page 2 of 3
DIGITOXIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: White or pale buff microcrystalline powder («0sol
1975); odorless (Merck 1983, p. 353)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Drugs or Medicines, Solid,
n.o.s.) Extinguish fire using agent suitable for type of surrounding fire
(material itself burns with difficulty.) Use water in flooding quantities
as fog. Use alcohol foam, carbon dioxide or dry chemical. (Student 1981,
P- 215)
Special Fire Fighting Procedures: (Non-Specific -- Drugs or Medicines,
Solid, n.o.s.) Avoid breathing dusts and fumes from burning material.
Keep unwind. Wear boots, protective gloves, and goggles (Student 1981, p.
216).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits acrid smoke and irritating fumes (Sax 1984, p. 1035).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 71-63-6
Page 3 of 3
DIGITOXIN
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (-Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): Material is bioactive
and capable of causing cardiac arrythmias and electrolyte imbalances that
may be fatal. Death is due to ventricular fibrillation or cardiac
standstill (*Gosselin 1976). Material has a high toxicity hazard rating;
it may cause death or permanent injury after a very short exposure (*Sax
1979). It is classified as super toxic; an estimated single lethal dose
is 3-10 mg (Gosselin 1984, p. 11-252).
Signs and Symptoms of Exposure: Nausea and vomiting, headache,
malaise, fatigue, weakness, drowsiness, abdominal discomfort are
symptomatic of toxicity. Visual disturbances (reduction in visual acuity,
illusions of flickering or shimmering lights, abnormal color vision) and
emotional disorders (including confusion, disorientation, aphasia,
delirium, hallucinations, and rarely convulsions) are also possible toxic
effects ("Gosselin 1976; -Grant 1974) .
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Medicines,
n.o.s.) Move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature (DOT 1984, Guide 11).
SECTION VI -- USE INFORMATION
Material is a cardiotonic drug (*Goodman 1975).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Drugs or Medicines, Solids, n.o.s.) Keep upwind. Wear
self-contained breathing apparatus. Avoid bodily contact with the
material. Wear full protective clothing. Wash away any material which
may have contacted the body with copious amounts of water or soap and
water (Student 1981, p. 216).
-------
CAS Registry Number: 72-20-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ENDRIN
CAS Registry Number: 72-20-8
Synonyms: l,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-Hexachloro-6,7-Epoxy-
l,4,4a,5;6,7,8,8a-0ctahydro-,endo,endo-; Compound 269; Endrex; Endricol; ENT
17,251; Experimental Insecticide 269; Hexachloroepoxyoctahydro-endo,endo-
Dimethanonaphthalene; Hexadrin; Mendrin; NCI-C00157; SD 3419; Oktanex; EN 57;
2,7:3,6-Dimethanonaphth[2,3-b]Oxirene, 3,4,5,6,9,9-Hexachloro-la,2,2a,
3,6,6a,7,7a-0ctahydro-, (la.alpha., 2.beta., 2a.beta., 3.alpha., 6.alpha.,
6a.beta., 7.beta., 7a.alpha.)-; Nendrin; 1,2,3,4,10,10-Hexachloro-6,7-epoxy-
l,4,4a,5,6,7,8,8a-octahydro-endo,endo-1,4:5,8-dimethanonaphthalene; 1,2,3,4,
10,10-Hexachloro-6,7-epoxy-l,4,4a,5,6,7,8,8a-octahydro-endo-l,4-endo-5,8-
dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-6,7-epoxy-l,4,4a,5,6,7,8,8a-
octahydro-l,4:5,8-endo,endo-dimethanonaphthalene; NCI 01565; C00157; Isodrin
Epoxide; Endrical
Chemical Formula: C10H0C1.0
12 O D
Molecular Weight: 380.90
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 0.1 mg/m3 (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.1 mg/m3; STEL 0.3 mg/m3 (skin) (*ACGIH 1980)
IDLH: 200 mg/m3 (*NIH EPA, OHM/TADS 1984)
Other Limits Recommended: STEL 0.5 mg/m3 for 30 minutes (Weiss 1980,
p. 402)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 1.7 at 68°F, 20°C (*USEPA 1980)
Vapor Pressure (mmHg): 2 x 10"7 at 77°F, 25°C (^Worthing 1979)
Melting Point: Decomposes at 473°F, 245°C (Merck 1983, p. 517)
-------
CAS Registry Number: 72-20-8
Page 2 of 4
ENDRIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (*IARC 1972-1985)
Appearance and Odor: White, crystalline solid; light tan color for
technical grade (*NFPA 1978). Odorless ("CHRIS 1978) or mild chemical
odor for technical grade (*IARC 1972-1985).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Commercial product may contain flammable
liquid with flashpoint 80°F, 27°C (*NIH EPA, OHM/TADS 1984)
Flammable Limits:
LEL: 1.1% (commercial product) (Weiss 1980, p. 402)
DEL: 7.0% (commercial product) (Weiss 1980, p. 402)
Extinguishing Methods: Use dry chemical, foam, carbon dioxide (*CHRIS
1978), water spray for solution (*NFPA 1978). Small fires: dry chemical,
carbon dioxide, water spray, or foam. Large fires: water spray, fog, or
foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Use water to keep fire-exposed
containers cool (*NFPA 1978). Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site. Move container from fire area if you
can do it without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (DOT 1984,
Guide 55).
Unusual Fire and Explosion Hazards: Toxic hydrogen chloride and
phosgene may be generated when solution burns (*CHRIS 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*USEPA 1980)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Strong oxidizers, strong acids
(*NIH EPA, OHM/TADS 1984), and parathion (Sax 1984, p. 1279)
-------
CAS Registry Number: 72-20-8
Page 3 of 4
ENDRIN
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: Toxic hydrogen chloride and
phosgene may be generated when solutions burn ("CHRIS 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*USEPA 1980)
Skin: Yes (*NFPA 1978)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): This material is
extremely toxic (*Gosselin 1976). It is rapidly absorbed through the skin
(*NFPA 1978). Symptoms appear between 20 minutes and 12 hours after
exposure (*Gosselin 1976). There is evidence that this material may cause
chromosomal damage ("USEPA 1980). Doses of 1 mg/kg can cause symptoms
(Sax 1984, p. 1278). It is a suspected carcinogen (Hawley 1981, p. 410).
Also, it is a central nervous system depressant and hepatotoxin (Farm
Chemicals Handbook 1984, p. C-93).
Signs and Symptoms of Exposure: It can cause death by respiratory
arrest. Symptoms include headache, nausea, vomiting, dizziness, tremors,
convulsions, loss of consciousness, rise in blood pressure, fever,
frothing of the mouth, deafness, coma, and death (*Gosselin 1976, Gosselin
1984, pp. 11-285, III-143).
Medical Conditions Generally Aggravated by Exposure: Pregnant women
are considered to be at special risk (-USEPA 1980).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 72-20-8
Page 4 of 4
ENORIN
SECTION VI -- USE INFORMATION
This material is used primarily as an insecticide for field crops
(^Worthing 1979). Only cotton and bird perch uses registered in the U.S.
(USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
For leaks or spills, use water spray to disperse vapor and to flush spills
(*NFPA 1978). Liquid containing this material should be absorbed in
vermiculite, dry sand, earth (*NIOSH/OSHA 1981). Do not touch spilled
material; stop leak if you can do it without risk. Small dry spills:
with clean shovel place material into clean, dry container and cover; move
containers from spill area. Large spills: dike far ahead of spill for
later disposal. Keep unnecessary people away; isolate hazard area and
deny entry. Ventilate closed spaces before entering them. Wear positive
pressure breathing apparatus and special protective clothing. Remove and
isolate contaminated clothing at the site (DOT 1984, Guide 55).
-------
CAS Registry Number: 74-83-9
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- METHYL BROMIDE
CAS Registry Number: 74-83-9
Synonyms: Brom-o-gas; Bromomethane; Curafume; Dowfume MC-2 Soil Fumigant;
Dowfume MC-33; Edco; Embafume; Halon 1001; Haltox; Iscobrome; Kayafume; MB;
MBX; MEBR; Metafume; Methane, Bromo-; Methogas; Monobromomethane; Pestmaster;
Profume; R 40B1; Rotox; Terabol; Terr-o-gas 100; Zytox
Chemical Formula: CH Br
Molecular Weight: 94.95
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: Ceiling Concentration 20 ppm (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 5 ppm (20 mg/m3); STEL 15 ppm (60 mg/m3) (skin)
(*ACGIH 1980)
IDLH: 2,000 ppm (NIOSH/OSHA 1978, p. 126)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boilmg Point: 38.4°F, 3.56°C (*Weast 1979)
Specific Gravity (H20=l): Liquid: 1.730 at 0°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 1420 at 20°C (*Merck 1976)
Melting Point: -136°F, -93.6°C (-Merck 1976)
Vapor Density (AIR=1): 3.27 (-NFPA 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1.34 g/100 g at 25°C (-Worthing 1979)
-------
CAS Registry Number: 74-83-9
Page 2 of 4
METHYL BROMIDE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless gas; usually odorless, but has a
sweetish chloroform-like odor at high concentrations ("Merck 1976).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): None (*Sax 1979)
Flammable Limits:
LEL: 10% ("Sax 1979)
UEL: 16% ("Sax 1979)
Extinguishing Methods: Non-flammable in air; burns in oxygen ("Merck
1976). Use water spray, foam, carbon dioxide, or dry chemical (*NFPA
1978).
Special Fire Fighting Procedures: Full protective clothing, including
self-contained breathing apparatus, coat, pants, gloves, boots, and bands
around legs, arms, and waist should be provided. No skin surface should
be exposed ("NFPA 1978). Move container from fire area if you can do it
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of bromides (*Sax 1979).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-NFPA 1978)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of bromides ("Sax 1979).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 603)
Conditions to Avoid: Not Found
-------
CAS Registry Number: 74-83-9
Page 3 of 4
METHYL BROMIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Gosselin 1976)
Skin: Yes (*Gosselin 1976)
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Methyl bromide is a
dangerous cumulative poison with delayed symptoms of central nervous
system intoxication that may appear as long as several months after
exposure ("White-Stevens 1971). High concentrations can produce fatal
pulmonary edema. Chronic exposure can cause central nervous system
depression and kidney injury ("Merck 1976). It may cause severe and
permanent brain damage. Severe neurological signs may appear when there
is a sudden exposure to high concentrations following continuous slight
exposure (*Encyc Occupat Health and Safety 1971). Methyl bromide has
practically no odor or irritating effects and therefore no warning, even
at hazardous concentrations (''"Clayton and Clayton 1981-82).
Signs and Symptoms of Exposure: Symptoms may appear 3-12 hours after
inhalation, including dizziness, headache, anorexia, nausea, vomiting,
abdominal pain, weakness, blurred vision, mental confusion, tremors,
convulsions, rapid respiration, collapse, and coma. Later there may be
bronchopneumonia, kidney failure, and severe weakness. Skin contact may
cause blistering, if evaporation is delayed (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
This material is used as an insecticide, rodenticide, fumigant, and
nematocide; as a chemical intermediate ("SRI); and as a fire extinguishing
agent (-Clayton and Clayton 1981-82).
-------
CAS Registry Number: 74-83-9
Page 4 of 4
METHYL BROMIDE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
In case of a small spill or leak, isolate 50 feet in all directions. In
case of a large spill, isolate 90 feet in all directions and evacuate an
area 0.3 miles long and 0.2 miles wide in a downwind direction (DOT 1984,
Table of Isolation and Evacuation Distances). Remove all ignition
sources. Ventilate area of spill or leak, stop flow of gas or remove
leaking cylinder to open air and repair leak or allow cylinder to empty.
If material is in the liquid form, allow it to vaporize (*NIOSH/OSHA
1981). Stay upwind, keep out of low areas. Wear positive pressure
breathing apparatus and special protective clothing. Use water spray to
reduce vapors (DOT 1984, Guide 55).
-------
CAS Registry Number: 74-90-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- HYDROCYANIC ACID
CAS Registry Number: 74-90-8
Synonyms: Hydrogen Cyanide; Prussic Acid; Aero Liquid HCN; Cyclon;
Cyclone B; Evercyn; Formic Anammonide; Formonitrile; Zaclondiscoids
Chemical Formula: HCN
Molecular Weight: 27.03
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: 10 ppm (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: Ceiling 10 ppm (*ACGIH 1980)
IDLH: 50 ppm (NIOSH/OSHA 1978, p. 112)
Other Limits Recommended: NIOSH Occupational Exposure Recommended
Standard -- 5 mg (cyanide)/m3 for 10 minutes (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 78.1°F, 25.6°C (*Merck 1976)
Specific Gravity (H20=l): 0.699 (liquid) (*Weast 1983)
Vapor Pressure (mmHg): 630 (^White-Stevens 1971)
Melting Point: 7.9°F, -13.4°C (*Merck 1983)
Vapor Density (AIR=1): 0.901 g/1 (*Weast 1983)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible with water (*Merck 1976)
Appearance and Odor: Colorless gas or liquid; bitter almond odor
(*Merck 1976; *CHRIS 1978)
-------
CAS Registry Number: 74-90-8
Page 2 of 4
HYDROCYANIC ACID
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 08F, -18°C (CC) (*NFPA 1978)
Flammable Limits:
LEL: 5.6% (*NFPA 1978)
UEL: 40.0% (*NFPA 1978)
Extinguishing Methods: Use dry chemicals, alcohol foam, or carbon
dioxide (*NFPA 1978). Small fires: let burn unless leak car. be stopped
immediately. Large fires: water spray, fog or foam. Move container from
fire area if you can do it without risk. Stay away from ends of tanks.
Withdraw immediately in case of rising sound from venting safety device or
any discoloration of tank due to fire. Cool container with water using
unmanned device until well after fire is out. Isolate area until gas has
dispersed (*DOT 1984).
Special Fire Fighting Procedures: Firefighting should be done from a
safe distance. A few whiffs of gas, or liquid penetrating firefighter's
protective clothing, could be fatal. Only special protective clothing
should be worn. Water spray should be used to keep containers cool (*NFPA
1978). Keep unnecessary people away; isolate hazard area and deny entry.
Stay upwind; keep out of low areas. Ventilate closed spaces before
entering them. Wear positive pressure breathing apparatus and special
protective clothing. Evacuate area endangered by gas. Isolate for 1/2
mile in all directions if tank car or truck is involved in fire (*DOT
1984).
Uni ual Fire and Explosion Hazards: Unstabilized hydrocyanic acid may
polymerize spontaneously with explosive violence (*Hawley 1981).
Flashback along vapor trail may occur (*CHRIS 1978). The explosion hazard
is severe when this material is exposed to heat, flame, or oxidizers (*Sax
1975). It forms explosive mixtures with air, and will react with water,
steam, acid, or acid fumes to produce highly toxic fumes of cyanides. It
may decompose explosively upon contact with alkaline material (Sax 1984,
p. 1548).
SECTION IV - REACTIVITY DATA
Stability: Unstable: Yes (*Hawley 1981)
Stable:
Conditions to Avoid: Hydrocyanic acid solution is sensitive to
light (*Hawley 1977). It may become unstable and subject to explosion
if stored for an extended time or exposed to high temperature and
pressure (*CHRIS 1978). Avoid heat, flame or oxidizers (Sax 1984, p.
1548).
-------
CAS Registry Number: 74-90-8
Page 3 of 4
HYDROCYANIC ACID
SECTION IV -- REACTIVITY DATA (Continued)
Incompatibility (Materials to Avoid): Acetylaldehyde, alkaline
materials, oxidizers, water, steam, acid, and acid fumes (Sax 1984, p.
1548)
Hazardous Decomposition or Byproducts: Toxic cyanide fumes (Sax 1984,
p. 1548)
Hazardous Polymerization: May Occur: Yes (*Hawley 1981)
May Not Occur:
Conditions to Avoid: Unstabilized hydrocyanic acid may polymerize
spontaneously with explosive violence (*Hawley 1981). Can polymerize
at 50°-60°C or when catalyzed with traces of alkali (Sax 1984, p.
1548).
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Goodman 1975)
Skin: Yes (*Encyc Occupat Health and Safety 1983)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): It is super toxic.
Breathing in a small amount of the gas or swallowing a very small amount
may be fatal (*NFPA 1978; *Gosselin 1976). Average fatal dose is 50-60
mg. A few minutes of exposure to 300 ppm may result in death. Exposure
to 150 ppm for 1/2 to 1 hour may endanger life (Merck 1983, p. 696).
Signs and Symptoms of Exposure: Exposure to hydrocyanic acid can cause
weakness; headache; confusion; nausea; vomiting; increased rate of
respiration or slow, gasping respiration; and eye and skin irritation
(NIOSH/OSHA 1978, p. 113). This is followed by collapse, coma,
convulsions, and death (Weiss 1980, p. 514).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: If hydrocyanic acid gets in the
eyes, wash with water immediately. If it gets on the skin, flush with
water immediately. If breathing has stopped, give artificial respiration
(NIOSH/OSHA 1978, p. 113). Avoid mouth-to-mouth resuscitation (*Rumack
1975 to Present). Use cyanide antidote kit (*Peer Review Committee).
Keep victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 13).
-------
CAS Registry Number: 74-90-8
Page 4 of 4
HYDROCYANIC ACID
SECTION VI -- USE INFORMATION
Hydrogen cyanide is used as a rodent poison and as a fumigant (*Rossoff
1974). It is a chemical intermediate in the manufacture of acrylates,
methacrylates, hexamethylenediamine, nitriles, and other materials (*Patty
1963). It is also used in metal polishes, electroplating solutions, and
metallurgical and photographic processes (*Gosselin 1976).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
In case of a small spill or leak, isolate 90 feet in all directions. For
a large spill, isolate 190 feet in all directions, then evacuate people
who are downwind, an area of 0.5 miles wide and 0.7 miles long. Stay
upwind; keep out of low areas. Ventilate closed spaces efore entering.
Wear positive pressure breathing apparatus and special protective
clothing. Use water spray to reduce vapors. Do not touch spilled
material; stop leak if you can do it without risk. Shut off ignition
sources; no flares, smoking, or flames in hazard area. Isolate area until
gas has dispersed (*DOT 1984).
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CAS Registry Number: 74-93-1
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- METHYL MERCAPTAN
CAS Registry Number: 74-93-1
Synonyms: Mercaptomethane; Methanethiol; Methyl Sulfhydrate; Thiomethanol;
Thiomethyl Alcohol
Chemical Formula: CH.S
4
Molecular Weight: 48.11
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: Ceiling 10 ppm/15 min., 20 mg/m3 (NIOSH/OSHA 1978,
p. 130)
ACGIH TLV: TWA 0.5 ppm, 1 mg/m3 (-ACGIH 1983)
IDLH: 400 ppm (*Encyc Occupat Health and Safety 1983)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 42.7°F, 5.95°C (*Merck 1983)
Specific Gravity (H20=l): 0.8665 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): 1 at -90.7°C; 10 at -67.5°C; 40 at -49.2°C; 100
at -34.8°C; 400 at -7.9°C; 760 at 6.8°C (*Weast 1979)
Melting Point: -189.4°F, -123°C (*Merck 1983)
Vapor Density (AIR=1): 1.66 (*Sax 1984)
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 74-93-1
Page 2 of 4
METHYL MERCAPTAN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: 23.30 g/liter (*Merck 1983)
Appearance and Odor: Water-white liquid when below boiling point, or
colorless gas (*Hawley 1981); odor of rotten cabbage ("Merck 1983)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 0°F, -18°C (^Sunshine 1969)
Flammable Limits:
LEL: 3.9% (Weiss 1980, p. 618)
UEL: 21.8% (Weiss 1980, p. 618)
Extinguishing Methods: Small fires: let burn unless leak can be
stopped immediately. Large fires: water spray, fog, or foam. Move
container from fire area if you can do so without risk. Stay away from
ends of tanks. Withdraw immediately in case of rising sound from venting
safety device or any discoloration of tank due to fire. Cool container
with water using unmanned device until well after fire is out. Isolate
area until gas has dispersed (DOT 1984, Guide 13). Preferably let fire
burn, stop gas flow. Fires may be extinguished with dry chemical, foam,
or carbon dioxide (Weiss 1980, p. 618).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing. Evacuate area
endangered by gas. Isolate for 1/2 mile in all directions if tank car or
truck is involved in fire (DOT 1984, Guide 13).
Unusual Fire and Explosion Hazards: Combustion produces irritating
sulfur dioxide. Flash back along vapor track may occur (*CHRIS 1978).
Very dangerous when exposed to heat, flame, or oxidizers. On
decomposition it emits highly toxic fumes of sulfur oxides. It will react
with water, steam or acids to produce toxic and flammable vapors; and can
react vigorously with oxidizing materials (Sax 1984, p. 1764).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*CHRIS 1978)
Conditions to Avoid: Direct sunlight, and areas of high fire
hazards (*Sax 1968)
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CAS Registry Number: 74-93-1
Page 3 of 4
METHYL MERCAPTAN
SECTION IV -- REACTIVITY DATA (Continued)
Incompatibility (Materials to Avoid): Incompatible with mercuric oxide
and oxidizing materials (Sax 1984, p. 1764).
Hazardous Decomposition or Byproducts: Irritating sulfur dioxide is
produced upon combustion (Weiss 1980, p. 618). When heated to
decomposition, it emits highly toxic fumes and flammable vapors (Sax 1984,
p. 1764).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 618)
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Weiss 1980, p. 618)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Can cause death by
respiratory paralysis ("ACGIH 1980). It is an eye and respiratory tract
irritant. Exposure results in pulmonary edema and hepatic and renal
damage (Clayton and Clayton 1981-82, p. 2067).
Signs and Symptoms of Exposure: Can cause death by respiratory
paralysis ("ACGIH 1980). Low level eye and mucous membrane irritation,
headache, dizziness, staggering stance, nausea and vomiting. Other
symptoms include bronchopneumonia, rapid breathing, and dermatitis
(Clayton and Clayton 1981-82, p. 2068).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 13).
-------
CAS Registry Number: 74-93-1
Page 4 of 4
METHYL MERCAPTAN
SECTION VI -- USE INFORMATION
Manufacturing of pesticides (*Merck 1983); chemical intermediate for
Pharmaceuticals; dimethyl sulfide; fungicides; methionine; in jet fuels;
in preparation of plastics (*SRI); and as a gas odorant to serve as a
warning property for odorless but hazardous gases ("Clayton and Clayton
1981-82).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Initial isolation: isolate 370 feet in all directions for small spills or
small leaks. If it is a large spill, first isolate 770 feet in all
directions and evacuate an area 1.9 miles wide and 3.0 miles long in a
downwind direction (DOT 1984, Table of Isolation and Evacuation
Distances). Keep unnecessary people away; isolate hazard area and deny
entry. Stay upwind; keep out of low areas. Ventilate closed spaces
before entering them. Wear positive pressure breathing apparatus and
special protective clothing. Do not touch spilled material; stop leak if
you can do so without risk. Shut off ignition sources; no flares,
smoking, or flames in hazard area. Use water spray to reduce vapors.
Isolate area until gas has dispersed (DOT 1984, Guide 13). Avoid
breathing vapors (see Section V above).
-------
CAS Registry Number: 75-15-0
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CARBON DISULFIDE
CAS Registry Number: 75-15-0
Synonyms: Carbon Bisulfide; Carbon Bisulphide; Carbon Bisulphide; Carbon
Sulfide; Dithiocarbonic Anhydride; NCI-C04591; Sulphocarbonic Anhydride;
Sulphuret of Carbon; Weeviltox
Chemical Formula: CS
Molecular Weight: 76.13
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 20 ppm; Ceiling Concentration 30 ppm; Peak
Concentration 100 ppm/30 minutes/8'hours (*NIOSH 1985)
ACGIH TLV: 10 ppm (approximately 30 mg/m3) (skin) (-ACGIH 1980)
IDLH: 500 ppm (NIOSH/OSHA 1978, p. 60)
Other Limits Recommended: Occupational Exposure to Carbon Bisulfide
Recommended Standard - Air: TWA 1 ppm; Ceiling Concentration 10 ppm/15
minutes (*NIOSH 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 116°F, 46.5°C (-Merck 1983)
Specific Gravity (H 0=1): 1.2632 at 20°C/4°C (--Merck 1983)
Vapor Pressure (mmHg): 360 at 25°C ("Sunshine 1969)
Melting Point: -167°F, -110.8°C (--Weast 1979)
Vapor Density (AIR=1): 2.67 (--Merck 1983)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.294% at 20°C (-Merck 1983)
Appearance and Odor: Mobile clear or faintly yellow liquid; reagent
and commercial grades are foul smelling. Pure distillates have sweet,
pleasing ethereal odor ("Merck 1983)
-------
CAS Registry Number: 75-15-0
Page 2 of 4
CARBON DISULFIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -22°F, -30°C (CC) (Merck 1983, p. 251)
Flammable Limits:
LEL: 1.3% (*Merck 1983); 1% (*Sunshine 1969)
DEL: 50% (-Merck 1983); 44% (-'Sunshine 1969)
Extinguishing Methods: Use dry chemical, carbon dioxide or other inert
gas. Cooling and blanketing with water spray is effective in case of
fires in metal containers or tanks to help prevent reignition by hot
surfaces. Foam is ineffective (NFPA 1984, p. 49-27).
Special Fire Fighting Procedures: If the vapor concentration exceeds 2
percent by volume or is unknown, self-contained breathing mask with full
face should be used by all persons entering contaminated area (*CHRIS
1978). Wear special protective clothing. Isolate for 1/2 mile in all
directions if tank car or truck is involved in fire (DOT 1984, Guide 28).
Unusual Fire and Explosion Hazards: Ignition temperature dangerously
low: 212°F, 100°C (Merck 1983, p. 251). Vapors may be ignited by contact
with ordinary light bulb (*NPFA 1978); when heated to decomposition, it
emits highly toxic fumes of oxides of sulfur (*Sax 1979).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (Merck 1983, p. 251)
Stable:
Conditions to Avoid: Decomposes on standing for a long time (Merck
1983, p. 251)
Incompatibility (Materials to Avoid): Air, rust, halogens, metal
azides, metals, oxidants; when exposed to heat or flame reacts violently
with aluminum, chlorine, azides, hypochlorite, ethylamine diamine,
ethylene imine, fluorine, metallic azides of lithium, potassium, cesium,
rubidium and sodium, nitrogen oxides, potassium, zinc and (sulfuric acid
plus permanganate) (Sax 1984, p. 641).
Hazardous Decomposition or Byproducts: When heated to decomposition,
emits highly toxic fumes of sulfur oxides and can react vigorously with
oxidizing materials (Sax 1984, p. 642).
-------
CAS Registry Number: 75-15-0
Page 3 of 4
CARBON DISULFIDE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-NIOSH/RTECS 1985)
Skin: Yes (*Gosselin 1976)
Ingestion: Yes (-NIOSH/RTECS 1985)
Health Hazards (Acute, Delayed, and Chronic): The material affects the
central nervous system, cardiovascular system, eyes, kidneys, liver, and
skin. It may be absorbed through the skin as a vapor or liquid, inhaled
or ingested. The probable oral lethal dose for a human is between 0.5 and
5 g/kg or between 1 ounce and 1 pint (or 1 pound) for a 70 kg (150 Ib.)
person (*Gosselin 1976). In chronic exposures, the central nervous system
is damaged and results in the disturbance of vision and sensory changes at
the most common early symptoms (Sax 1984, p. 641). Lowest lethal dose for
humans has been reported at 14 mg/kg or 0.98 grams for a 70 kg person
(*NIOSH/RTECS 1985).
Signs and Symptoms of Exposure: In acute poisoning, early excitation
of the central nervous system occurs, followed by depression with stupor,
restlessness, and unconsciousness. If recovery occurs, the patient
usually passes through the after-stage of narcosis, with nausea, vomiting,
headache, etc. (Sax 1984 p. 642). Also possible are motor disturbances of
the bowel, anemia, disturbances of cardiac rhythm, loss of weight,
polyuria and menstrual disorders. Severe chronic poisoning may also
result in liver degeneration and jaundice ("Thienes 1972) .
Medical Conditions Generally Aggravated by Exposure: Alcoholics and
those suffering from neuropsychic trouble are at special risk ("LeFaux
1968).
Emergency and First Aid Procedures: Call for emergency medical care.
Remove victim from contaminated area and administer oxygen and artificial
respiration, if needed. Wash affected areas with copious amounts of
water. If this material is swallowed and victim is conscious, have victim
drink water or milk and have victim induce vomiting; if victim is
unconscious or having convulsions, keep victim warm and do not induce
vomiting (Weiss 1980, p. 232).
-------
CAS Registry Number: 75-15-0
Page 4 of 4
CARBON DISULFIDE
SECTION VI -- USE INFORMATION
Carbon disulfide is used in the manufacture of soil disinfectants and
vacuum tubes and is used as a solvent for cleaning and extractions,
especially in metal treatment and plating. It is a fumigant for
commodities, a corrosion inhibitor, and a polymerization inhibitor for
vinyl chloride (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
In case of a spill: (1) remove all ignition sources, (2) ventilate area
of spill or leak, and (3) for small quantities, absorb on paper towels.
Evaporate the spills in a safe place, such as a fume hood. Large
quantities can be reclaimed or collected and atomized in a suitable
combustion chamber equipped with an appropriate effluent gas-cleaning
device (*NIOSH/OSHA 1981). If carbon disulfide is spilled in water,
neutralize with agricultural lime, crushed limestone, or sodium
bicarbonate. If dissolved, apply activated carbon at ten times the
spilled amount. Use mechanical dredges or lifts to remove immobilized
masses of pollutants and precipitates (Student 1981, p. 106). In case of
a spill or leak from a drum or smaller container or a small leak from a
tank, isolate 50 feet in all directions. In case of a large spill, first
isolate 100 feet in all directions, then evacuate in a downwind direction
an area 0.2 miles wide and 0.3 miles long (DOT 1984, Table of Isolation
and Evacuation Distances). Do not touch spilled material; stop leak if
you can do it without risk. Use water spray to reduce vapors. Wear
positive pressure breathing apparatus and special protective clothing (DOT
1984, Guide 28).
-------
CAS Registry Number: 75-18-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DIMETHYL SULFIDE
CAS Registry Number: 75-18-3
Synonyms: 2-Thiapropane; 2-Thiopropane; Dimethyl Monosulfide; Dimethyl
Sulphide; Dimethyl Thioether; DMS, Exact-S; Methane, Thiobis-;
Methanethiomethane; Methyl Monosulfide; Methyl Sulphide; Methylthiomethane;
Thiobismethane
Chemical Formula: C.H,S
2. D
Molecular Weight: 62.13
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: I'Csn inhalation
(mouse) 0.031 mg/liter (-NIOSH/RTECS 1985) (SUSPECT)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 99.7°F, 37.3°C (*Weast 1979)
Specific Gravity (H20=l): 0.8483 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): 15 (-Clayton and Clayton 1981-82) (SUSPECT)
Melting Point: -144.9°F, -98.27°C (*Weast 1979)
Vapor Density (AIR=1): 2.14 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (-Weast 1979)
Appearance and Odor: Colorless liquid with an unpleasant, wild radish,
cabbage-like odor (-Fenaroli 1975).
-------
CAS Registry Number: 75-18-3
Page 2 of 3
DIMETHYL SULFIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -55°F (*Clayton and Clayton 1981-82)
Flammable Limits:
LEL: 2.2% (*Sax 1979)
UEL: 19.7% (*Sax 1979)
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog or foam (-DOT 1984).
Special Fire Fighting Procedures: Wear self-contained breathing
apparatus and full protective clothing. Move container from fire area.
Cool containers that are exposed to flames with water from the side until
well after the fire is out. For massive fire in cargo area, used unmanned
hose holder or monitor nozzles; if this is impossible withdraw from area
and let fire burn. Withdraw immediately in case of rising sound from
venting safety device or any discoloration of tank due to fire. Isolate
for 1/2 mile in all directions if tank car or truck is involved in fire
(*DOT 1984).
Unusual Fire and Explosion Hazards: Flammable/combustible material,
may be ignited by heat, sparks or flames. Vapors may travel to a source
of ignition and flash back. Container may explode in heat of fire. Vapor
explosion hazard indoors, outdoors or in sewers ("DOT 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Reacts vigorously with oxidizing
materials ("Sax 1979). Incompatible with dibenzoyl peroxide (Sax 1984, p.
1201).
Hazardous Decomposition or Byproducts: Combustion products include
toxic and irritating fumes of sulfur dioxide (Weiss 1980, p. 367).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 367)
Conditions to Avoid: Not Found
-------
CAS Registry Number: 75-18-3
Page 3 of 3
DIMETHYL SULFIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Clayton and Clayton 1981-82)
Skin: Yes (--Clayton and Clayton 1981-82)
Ingestion: Yes ("Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): Dimethyl sulfide causes
softening and irritation of the skin. Orally it is an irritant (*Sax
1975). It is a moderate eye irritant (-Clayton and Clayton 1981-82). It
is an eye, nose, throat and skin irritant (*VCHRIS 1978).
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush eyes with running water for at least 15 minutes. Wash
skin with soap and water. Remove and isolate contaminated clothing and
shoes at the site (-DOT 1984).
SECTION VI -- USE INFORMATION
It is a gas odorant, catalyst impregnator, solvent for anhydrous mineral
salts, flavoring ingredient in foods and beverages, chemical intermediate
for solvents and dimethyl sulfoxide (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind. Wear self-contained breathing apparatus and full protective
clothing. Shut off ignition sources; no flares, smoking or flames in
hazard area. Stop leak. Use water spray to reduce vapors. Take up
spills with noncombustible absorbent material (*DOT 1984).
-------
CAS Registry Number: 75-21-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ETHYLENE OXIDE
CAS Registry Number: 75-21-8
Synonyms: alpha, beta-Oxidoethane; Anprolene; Dihydrooxirene; Dimethylene
Oxide; E 0; ETO; NCI-C50088; Oxacyclopropane; Oxane; Oxidoethane;
1,2-Epoxyefhane; Oxiran; Oxirane; Oxirene, Dihydro-; Oxyfume; Oxyfume 12; T-Gas
Chemical Formula: C0H,0
2 4
Molecular Weight: 44.06
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 50 ppra (*48 FR 17284, 1983)
ACGIH TLV: 1 ppm (2 mg/m3) (*ACGIH 1984)
IDLH: 800 ppm (*NIOSH/OSHA 1981)
Other Limits Recommended: Ceiling concentration of 75 ppm (135
mg/m3) determined during a 15 minute period ("NIOSH 1981). Industrial
substance suspect of carcinogenic potential for humans -- recommended TLV
1 ppm (ACGIH 1984, p. 42).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 51.3°F, 10.7°C (*Sunshine 1969)
Specific Gravity (H20=l): 0.8222 at 10°C/10°C (*Sunshine 1969)
Vapor Pressure (mmHg): 1095 at 20°C (NIOSH/OSHA 1978, p. 100)
Melting Point: -170.5°F. -112.5°C (-Sunshine 1969)
Vapor Density (AIR=1): 1.49 (^Environment Canada 1982)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (*Merck 1976)
Appearance and Odor: Colorless gas at room temperature but a mobile
liquid below 12°C (54°F) and has a sweet odor (*Merck 1976; *CHRIS 1978)
-------
CAS Registry Number: 75-21-8
Page 2 of 4
ETHYLENE OXIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Greater than -18°C (-Sunshine 1969); but
less than 0°F (OC) (-CHRIS 1978)
Flammable Limits:
LEL: 3.0% (*Sax 1975)
DEL: 100% (*Sax 1975)
Extinguishing Methods: Extinguish with alcohol foam, carbon dioxide,
dry chemical or water spray, fog, or foam. Let burn unless leak can be
stopped immediately (-DOT 1984).
Special Fire Fighting Procedures: Move container from fire area if you
can do so without risk. Stay away from ends of tanks. Fight fire from
maximum distance. For massive fire in cargo area, use unmanned hose
holder or monitor nozzles; if this is impossible, withdraw from area and
let fire burn. Withdraw immediately in case of rising sound from venting
safety device or any discoloration of tank due to fire. Isolate for 1
mile in all directions if tank car or truck is involved in fire. Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Wear positive pressure breathing apparatus and
full protective clothing. Evacuate area endangered by gas (-DOT 1984).
Unusual Fire and Explosion Hazards: Severe explosion hazard when
exposed to heat or flame (Sax 1984, p. 1348). Irritating vapors are
generated when heated. Vapor is heavier than air and may travel
considerable distance to a source of ignition and flash back (*CHRIS
1978). Vapor forms explosive mixtures with air over a wide range (-NFPA
1978). Liquid is not detonable but the vapor may be readily initiated
into explosive decomposition (-Bretherick 1979).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (-NFPA 1978)
Stable:
Conditions to Avoid: Air, heat, acids and bases (Sax 1984,
p. 1348); metal or metal chloride catalysts (-NFPA 1978)
Incompatibility (Materials to Avoid): Metal fittings containing
copper, silver, mercury or magnesium; ammonia ("Bretherick 1979);
pharmaceutical substances; vitamins; amino acids; food constituents (*0sol
1975); oxidizing agents; acids, organic bases; amines; certain salts;
alcohols; mercaptans (-General Electric Co. 1980, MSDS #433); ferric
chloride; magnesium perchlorate; m-nitroaniline; trimethylamine (*ITI
1982); potassium, tin chlorides; contaminants; alkanethiols; bromoethane;
aluminum chloride; aluminum oxide; iron chlorides; and iron oxides (Sax
1984, p. 1348).
-------
CAS Registry Number: 75-21-8
Page 3 of 4
ETHYLENE OXIDE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: Decomposition products are
explosive (*ITI 1982).
Hazardous Polymerization: May Occur: Yes ("Sax 1975)
May Not Occur:
Conditions to Avoid: Acids; covalent halides such as chlorides of
aluminum, iron (III), tin (IV); basic materials like alkali hydrides,
ammonia, amines, and potassium; catalytically active solids such as
aluminum or iron oxides or rust ("Bretherick 1975); chlorides of
boron, aluminum, tin, and iron; some carbonates; and metals such as
copper and copper alloys (*Patty 1963)
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Oilman 1980)
Skin: Yes (Sax 1984, p. 1348)
Ingestion: Yes (Sax 1984, p. 1348)
Health Hazards (Acute, Delayed, and Chronic): It can cause death. Low
toxic concentration when inhaled is 12500 ppm/10 seconds (*NIOSH/RTECS
1985). It is a strong skin irritant (-CHRIS 1978). Neurological
disorders and even death have been reported (-Gilman 1980).
Signs and Symptoms of Exposure: Low vapor concentration often results
in delayed nausea and vomiting. Higher concentration produces irritation
of eyes, nose and throat (-CHRIS 1978).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Remove and isolate contaminated clothing and shoes at the site.
Keep victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (-DOT 1984).
-------
CAS Registry Number: 75-21-8
Page 4 of 4
ETHYLENE OXIDE
SECTION VI -- USE INFORMATION
Ethylene oxide is a chemical intermediate for ethylene glycol, nonionic
surfactants, glycol ethers, ethanolamines, triethylene glycol, and
polyethylene glycol ("SRI). Used as a fumigant for foodstuffs and
textiles, for sterilizing surgical instruments, and as an agricultural
fungicide (Merck 1983, p. 550). Registered as a pesticide in the U.S.
(USEPA/Active Ingredients 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact. Wear proper eye and respiratory
protection and protective clothing (see Section V above). Shut off
ignition sources; do not allow flares, smoking or flames in the hazard
area. Stop leak if you can do so without risk. Use water spray to reduce
vapors; do not get water inside container. For small spills flush area
with flooding amounts of water. For large spills dike spill for later
disposal. If there is a spill or leak from a drum or smaller container or
a small leak from a tank, then isolate 80 feet in all directions. If
there is a large spill from a tank or from many containers or drums, etc.,
first isolate 160 feet in all directions. Then evacuate in a downwind
direction, an area 0.4 miles wide and 0.5 miles long (*DOT 1984).
-------
CAS Registry Number: 75-44-5
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PHOSGENE
CAS Registry Number: 75-44-5
Synonyms: Carbon Oxychloride; Carbonyl Chloride; CG; Chloroformyl
Chloride^ NCI-C60219; Carbon Dichloride Oxide; Carbonic Acid Bichloride;
Carbonic Dichloride; Carbonyl Dichloride; Phosgen
Chemical Formula: CC1 0
Molecular Weight: 98.92
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 0.1 ppm (*NIOSH 1977)
ACGIH TLV: 0.1 ppm (*ACGIH 1979)
IDLH: 2 ppm (NIOSH/OSHA 1978, p. 154)
Other Limits Recommended: Recommended standard: Air: TWA 0.1 ppm;
Ceiling 0.2 ppm for 15 minutes (*NIOSH 1977)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 47°F, 8.2°C (*Merck 1976)
Specific Gravity (H20=l): 1.432 at 0°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 1215 at 20°C (*Merck 1976)
Melting Point: -180°F, -118°C (*Merck 1976)
Vapor Density (AIR=1): 3.4 (*NFPA 1975)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (*Merck 1976)
-------
CAS Registry Number: 75-44-5
Page 2 of 4
PHOSGENE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless gas; colorless, fuming liquid;
suffocating odor reminiscent of moldy hay (*Merck 1976). In dilute
concentration has odor of green corn (*Arena 1974); odor similar to
decaying fruit at room temperature (*Encyc Occupat Health and Safety 1971)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Nonflammable (NFPA 1984, .>. 49-73). For small
fires, use dry chemical or carbon dioxide. Use water spray, fog, or foam
for larger fires. Do not get water inside containers. Move container
from fire area if you can do so without risk. Stay away from the ends of
tanks, and cool exposed containers with water until well after the fire is
out. Isolate the area until gas has dispersed (*DOT 1984).
Special Fire Fighting Procedures: If necessary to stop flow of gas,
use water spray to protect the personnel effecting shutoff. Sodium
hydroxide or anhydrous ammonia have been used to neutralize phosgene
(*NFPA 1975).
Unusual Fire and Explosion Hazards: When heated to decomposition or on
contact with water or steam, it will react to produce toxic and corrosive
fumes (*Sax 1975).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes, in steel containers if dry (U.S. Army 1975,
P- 3-1)
Conditions to Avoid: Moisture (*Sax 1975)
Incompatibility (Materials to Avoid): Reacts violently with aluminum;
tert-butyl azido formate; 2,4-hexadiyn-l,6-diol; isopropyl alcohol;
potassium; sodium; hexafluoro isopropylidene; amino lithium; lithium (Sax
1984, p. 2211).
Hazardous Decomposition or Byproducts: When heated to decomposition or
on contact with water or steam, it will react to produce toxic and
corrosive fumes (*Sax 1975).
-------
CAS Registry Number: 75-44-5
P«jge 3 of 4
PHOSGENE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*DOT 1984)
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Phosgene is a lung
toxicant that causes damage to t'e capillaries, bronchioles and alveoli of
the lungs (U.S. Army 1975, p. 3-1) by decomposition to hydrochloric acid.
There is little immediate irritant effect upon the respiratory tract, and
the warning properties of the gas are therefore very slight Pulmonary
edema, bronchopneumonia and occasionally lung abscesses develop.
Degenerative changes in the nerves have been reported as later
developments. A concentration of 25 ppm is dangerous for exposures
lasting 30-60 minutes and 50 ppm is rapidly fatal after even short
exposure (Sax 1984, p. 2210).
Signs and Symptoms of Exposure: The severity of poisoning cannot be
estimated from the immediate symptoms, since the full effect is not
usually apparent until 3 or 4 hours after exposure (U.S. Army 1975, p.
3-1). After the latent period, burning in the throat and chest, shortness
of breath and labored breathing are common symptoms. There may be moist
rales in the chest. If the exposure is severe, the development of
pulmonary edema may be so rapid that the patient dies within 36 hours
after exposure. In less severe exposures, pneumonia may develop several
days after the accident (Sax 1984, p. 2210). Contact may cause burns to
the skin and eyes (*DOT 1984).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water. Keep victim quiet.
Effects may be delayed, keep victim under observation (*DOT 1984).
-------
CAS Registry Number: 75-44-5
Page 4 of 4
PHOSGENE
SECTION VI -- USE INFORMATION
Delayed-action military chemical agent (U.S. Army 1975, p. 3-1). Chemical
intermediate for toluene diisocyanate, methyl isocyanate, acyl chlorides,
diphenylmethane-4,41-diisocyanate, chloroformate esters, diethyl carbonate,
dimethyl carbamoyl chloride, polymethylene polyphenylisocyanate,
polycarbonate resins (*SRI); aniline dyes (^Hamilton 1974); pesticides,
herbicides, dyes (Hawley 1981, p. 807).
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Respiratory protective equipment must be available. Suitable emergency
masks are those with acid gas canisters. For extended use, supplied-air
respirators or self-contained breathing equipment are necessary (*Encyc
Occupat Health and Safety 1971). Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind and keep out of low areas.
Ventilate closed spaces before entering. Isolate 600 feet in all
directions for a small spill. For a large spill, first isolate 1,250 feet
in all directions, and then evacuate in a downwind direction an area 3.3
miles wide and 5.2 miles long (*DOT 1984).
-------
CAS Registry Number: 75-55-8
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- PROPYLENEIMINE
CAS Registry Number: 75-55-8
Synonyms: Aziridine, 2-Methyl-; 2-Methylazacyclopropane; 2-Methylaziridine;
2-Methylethylenimine; Methylethylenimine; Propylenimine; Propylene Imine
Chemical Formula: C3H7N
Molecular Weight: 57.11
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: 2 ppm (5 mg/m3) (NIOSH/OSHA 1978, p. 160)
ACGIH TLV: TWA 2 ppm (5 mg/m3) (skin) (ACGIH 1985, p. 28)
IDLH: 500 ppm (NIOSH/OSHA 1978, p. 160)
Other Limits Recommended: Industrial substances suspect of
carcinogenic potential to man (*ACGIH 1983)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 151-153°F, 66-67°C (*Encyc Occupat Health and Safety
1983)
Specific Gravity (H20=l): 0.8039-0.8070 at 25°C/25°C (Hawley 1981,
p. 865)
Vapor Pressure (mmHg): 112 at 20°C (*IARC 1972-1985)
Melting Point: -85°F, -65°C (*IARC 1972-1985)
Vapor Density (AIR=1): 2.0 (*Encyc Occupat Health and Safety 1983)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (*IARC 1972-1985)
Appearance and Odor: Colorless, oily liquid with an odor similar to
aliphatic amines (i.e., fishy) (*IARC 1972-1985)
-------
CAS Registry Number: 75-55-8
Page 2 of 3
PROPYLENEIMINE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 25°F (CC) (-ACGIH 1980)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: If material is on fire, use foam, carbon
dioxide, or dry chemical (Student 1981, p. 433).
Special Fire Fighting Procedures: If material is on fire, do not
extinguish fire unless flow can be stopped. Use water in flooding
quantities as a "fog" and use to cool all affected containers. Keep
material out of water sources and sewers. Build dikes to contain flow as
necessary (Student 1981, p. 433).
Unusual Fire and Explosion Hazards: Chemical is extremely flammable;
vapors are heavier than air (Student 1981, pp. 433).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Thermally unstable (Student 1981, p. 433)
Stable:
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Acids, strong oxidizers (NIOSH/
OSHA 1978, p. 160)
Hazardous Decomposition or Byproducts: Toxic oxides of nitrogen are
produced during combustion (Student 1981, p. 433).
Hazardous Polymerization: May Occur: Yes (Student 1981, p. 433)
May Not Occur:
Conditions to Avoid: Contact with acid promotes violent
polymerization (Student 1981, p. 433)
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 865)
Skin: Yes (Hawley 1981, p. 865)
Ingestion: Yes (Hawley 1981, p. 865)
-------
CAS Registry Number: 75-55-8
Page 3 of 3
PROPYLENEIMINE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Toxic after acute
exposure. Can severely irritate eyes, skin, and lungs ("Encyc Occupat
Health and Safety 1983).
Signs and Symptoms of Exposure: Inflammation and blistering of the
skin, eye and upper respiratory tract; irritation, nausea, itching, and
periodic vomiting. Headache, dizziness, and pain in the temple.
Shortness of breath, and increased nasal and laryngeal secretion are seen
("Encyc Occupat Health and Safety 1983).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If victim is not breathing, give artificial
respiration; if breathing is labored, give oxygen. In case of eye/skin
contact, immediately flush with water for at least 15 minutes (DOT 1984,
Guide 30). Neutralization with acids (e.g., vinegar, fruit juices) is
contraindicated. Avoid vomiting (••Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
Propyleneimine is used as a chemical intermediate in the modification of
latex surface coating resins, polymers in textile and paper industries,
dyes, photography, gelatins, oil additives and organic synthesis. It is a
comoriomer for polymers with methacrylic acid and esters (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors; wear self-contained breathing apparatus. Avoid
bodily contact with the material; wear full protective clothing. Do not
handle broken packages without protective equipment. Wash away any
material which may have contacted the body with copious amounts of water
or soap with water. Use water spray to disperse vapors and dilute
standing pools of liquid. Keep sparks and flames away. Attempt to stop
leak if it can be done without hazard. (Student 1981, p. 433).
-------
CAS Registry Number: 75-56-9
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PROPYLENE OXIDE
CAS Registry Number: 75-56-9
Synonyms: 1,2-Epoxypropane; Epoxypropane; Ethylene oxide, Methyl-; Methyl
Ethylene Oxide; Methyl Oxirane; Methyloxirane; NCI-C50099; Oxirane, Methyl-;
Propane, 1,2-Epoxy-; Propanex Epoxy-; Propene Oxide; Propylene Epoxide;
Propylene Oxide; Propyleneoxide; 1,2-Propylene Oxide
Chemical Formula: C,H,0
j o
Molecular Weight: 58.08
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 100 ppm (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 20 ppm (50 mg/m3) (-ACGIH 1983)
IDLH: 2000 ppm (NIOSH/OSHA 1978, p. 160)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 93.61°F, 34.23°C (*Merck 1976)
<2
Specific Gravity (H,0=l): 0.859 at 0°C/4°C (''-Merck 1976)
Vapor Pressure (mmHg): 445 at 20°C (-Sunshine 1969)
Melting Point: -169.83°F, -112.13°C (*Merck 1976)
Vapor Density (AIR=1): 2.0 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 40.5% by weight at 20°C (''-Merck 1976)
-------
CAS Registry Number: 75-56-9
Page 2 of 4
PROPYLENE OXIDE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless liquid (*Merck 1976) with sweet,
alcoholic odor like natural gas, ether, or benzene (^Clayton and Clayton
1981-82)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash. Point (Method Used): -35°F, -37°C (CC) (^Sunshine 1969)
Flammable Limits:
LEL: 2.8% (*Sax 1979)
DEL: 37% (*Sax 1979)
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog or foam (DOT 1984, Guide 26).
Special Fire Fighting Procedures: Firefighting should be done from a
safe distance or from a protected location (*NFPA 1978). Wear self-
contained (positive pressure if available) breathing apparatus and full
protective clothing. Isolate for 1/2 mile in all directions if tank car
or truck is involved in fire. Move container from area if you can do so
without risk. Spray cooling water on containers that are exposed to
flames until well after fire is out. For massive fire in cargo area, use
unmanned hose holder or monitor nozzles; if this is impossible, withdraw
from area and let fire burn. Withdraw immediately in case of rising sound
from venting safety device or any discoloration of tank due to fire (DOT
1984, Guide 26).
Unusual Fire and Explosion Hazards: Vapor is heavier than air and may
travel considerable distance to source of ignition and flash back. Vapors
form explosive mixture with air. If polymerization takes place in
container, there may be a violent rupture of container (*NFPA 1978).
Explosion hazard is severe when exposed to flame ("Sax 1979).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 787)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Violently reacts with acetylide-
forming metals such as copper or copper alloys (^Clayton and Clayton
1981-82); ammonium hydroxide; chlorosulfonic acid; hydrochloric acid;
hydrofluoric acid; nitric acid; oleum and sulfurie acid (Sax 1984, p.
1289).
-------
CAS Registry Number: 75-56-9
Page 3 of 4
PROPYLENE OXIDE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Yes (*Clayton and Clayton
1981-82)
May Not Occur:
Conditions to Avoid: Active catalytic surfaces such as anhydrous
chlorides of iron, tin, and aluminum; peroxides of iron and ajuminum;
and alkali metal hydroxides (*NFPA 1978); high temperatures; alkalies;
aqueous acids; amines and acidic alcohols (Weiss 1980, p. 787).
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Clayton and Clayton 1981-82)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): This material is
moderately toxic by inhalation and ingestion. It may cause irreversible
and reversible changes (*Sax 1975). Skin contact with the material or
solutions of the material cause irritation; diluted solutions are more
irritating than undiluted materials (*Encyc Occupat Health and Safety
1971). Exposure may cause mild depression of the central nervous system
and eye, nasal and lung irritation (*Rumack 1975 to Present). Contact
with the liquid can cause blindness and death. Pulmonary edema may recur
up to 2 weeks after exposure ("Morgan 1982).
Signs and Symptoms of Exposure: Exposure may cause headache, nausea,
vomiting, and drunkenness (*Rumack 1975 to Present). Eye contact may
cause burns (*Encyc Occupat Health and Safety 1971).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: In case of inhalation, move victim
to fresh air immediately. Keep quiet and warm. If breathing stops, give
artificial respiration. In case of skin or eye contact, immediately flush
with plenty of water for at least 15 minutes. Immediately remove
contaminated clothing, watch bands, rings, etc. If material is swallowed,
have victim drink water or milk (Weiss 1980, p. 787).
-------
CAS Registry Number: 75-56-9
Page 4 of 4
PROPYLENE OXIDE
SECTION VI -- USE INFORMATION
This material is used primarily as a chemical intermediate for
polyurethane polyols, propylene glycol, and dipropylene glycol (*SRI). It
is also used for sterilization of packaged foods (*Farm Chemicals Handbook
1983), as a herbicide (*Clayton and Clayton 1981-82), in the preparation
of lubricants, surfactants, and oil demulsifiers, and as a fumigant, and
soil sterilant (*Merck 1976).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Ventilate area of spill or leak. Do not allow the material to enter
confined space, such as a sewer, because of the possibility of an
explosion (*NIOSH/OSHA 1981). Stop discharge if possible. Stay upwind
and use water spray to knock down vapor. Avoid contact with liquid and
vapor. Wear goggles, self-contained breathing apparatus, and rubber
overclothing (Weiss 1980, p. 787). Water spray may be used to flush
spills away from exposure and to dilute spills to nonflammable mixture
(*NFPA 1978). Shut off ignition sources; no flares, smoking or flames in
hazard area. Stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 26).
-------
CAS Registry Number: 75-74-1
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- TETRAMETHYL LEAD
CAS Registry Number: 75-74-1
Synonyms: Lead Tetramethyl; Methylplumbane; TML
Chemical Formula: C.H,.Pb
4 12
Molecular Weight: 267.33
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 0.075 mg (Lead)/m3 (skin) (OSHA 1984, p. 663)
ACGIH TLV: TWA 0.15 mg (Lead)/ra3 (skin), STEL 0.5 mg (Lead)/m3
(skin) (ACGIH 1985, p. 30)
IDLH: 40 mg/m3 (NIOSH/OSHA 1978, p. 176)
Other Limits Recommended: Maximum air concentration: 0.15 mg/m3
(skin) (*Casarett 1975)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 230°F, 110°C at 10 mmHg (*IARC 1972-1985); decomposes
above 212°F, 100°C (-NFPA 1975)
Specific Gravity (H20=l): 1.995 (-Weast 1976)
Vapor Pressure (mmHg): 22 at 20°C (NIOSH/OSHA 1978, p. 176)
Melting Point: -17.5°F, -27.5°C (*Weast 1976)
Vapor Density (AIR=1): 6.5 (NFPA 1984, p. 325M-87) (SUSPECT)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*IARC 1972-1985)
Appearance and Odor: Colorless liquid (*Encyc Occupat Health and
Safety 1971); dyed red, orange or blue with a slight musty odor
(NIOSH/OSHA 1978, p. 176).
-------
CAS Registry Number: 75-74-1
Page 2 of 3
TETRAMETHYL LEAD
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 38°C (*IARC 1972-1985)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: On fires in which containers are not exposed,
use water spray, dry chemical, foam or carbon dioxide (*NFPA 1975).
Special Fire Fighting Procedures: Use water to keep fire exposed
containers cool. If leak or spill has not ignited, use water spray to
disperse vapors or flush spill (*NFPA 1975). For massive fire in cargo
area, use unmanned hose holder or monitor nozzle; if this is impossible
withdraw from area and let fire burn (*DOT 1984).
Unusual Fire and Explosion Hazards: Thermal decomposition is likely to
take the form of vapors at the surface. Rapid decomposition will cause
container to explode (*NFPA 1975). Dangerous fire hazard when exposed to
heat, flame, or oxidizers (Sax 1984, p. 2546).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 865)
Conditions to Avoid: Fire, heat, physical damage, and strong
oxidizers (-NFPA 1975). Starts to decompose at about 212°F (100°C).
If confined, may explode or detonate at high temperatures (Weiss 1980,
p. 865).
Incompatibility (Materials to Avoid): Strong oxidizers such as
sulfuryl chloride or potassium permanganate (NIOSH/OSHA 1978, p. 176).
Hazardous Decomposition or Byproducts: Toxic gases are generated in
fire (Weiss 1980, p. 865).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 865)
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*NFPA 1975)
Skin: Yes (*NFPA 1975)
Ingestion: Yes (*NFPA 1975)
-------
CAS Registry Number: 75-74-1
Page 3 of 3
TETRAMETHYL LEAD
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Vapors are very toxic.
Fatal lead poisoning may occur by ingestion, vapor inhalation or skin
absorption (*NFPA 1975). Several cases of acute toxicity, usually in the
form of degenerative brain disease, have been described following
occupational exposure (*IARC 1972-1985).
Signs and Symptoms of Exposure: If inhaled or absorbed by skin, may
cause insomnia, excitability, delirium, coma and death. Vapors cause a
slight irritation of the eyes or respiratory system if present in high
concentrations. Causes irritation of the skin and first degree burns on
short exposure; may cause secondary burns on long exposure (Weiss 1980, p.
865). Other symptoms include bad dreams, anxiety, low blood pressure,
nausea, mania, and convulsions (NIOSH/OSHA 1978, p. 176).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal temperature. Effects may be delayed;
keep victim under observation (-DOT 1984).
SECTION VI -- USE INFORMATION
Antiknock additive for gasolines; component of mixed alkyl leads for
gasoline additives (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Wear positive pressure breathing apparatus and special protective
clothing. Do not touch spilled material; stop leak if you can do it
without risk. Use water spray to reduce vapors. Small spills: take up
with sand or other non-combustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (-DOT 1984).
-------
CAS Registry Number: 75-77-4
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- TRIMETHYLCHLOROSILANE
CAS Registry Number: 75-77-4
Synonyms: Chlorotrimethylsilane; Monochlorotriraethylsilicon; Silane',
Chlorotrimethyl-; Silane, Trimethylchloro-; Silicane, Chlorotrimethyl;
Silylium, Trimethyl-, Chloride; Trimethyl Chlorosilane; Trimethylsilyl Chloride
Chemical Formula: C H_ClSi
Molecular Weight: 108.66
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC.. inhalation
(mouse) 0.5 mg/liter/10 minutes (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 135°F, 57°C (*Hawley 1977)
Specific Gravity (H20=l): 0.854 at 25°C (*Hawley 1977)
Vapor Pressure (mmHg): Not Found
Melting Point: -72°F, -57.7°C (*Weast 1984)
Vapor Density (AIR=1): 3.7 (*CHRIS 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Decomposes in water (*Hawley 1977)
Appearance and Odor: Colorless liquid (*Hawley 1977), with a sharp
hydrochloric acid-like odor (*CHRIS 1978).
-------
CAS Registry Number: 75-77-4
Page 2 of 3
TRIMETHYLCHLOROSILANE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -18°F (*Hawley 1977); 0°F (OC) (*CHRIS 1978)
Flammable Limits:
LEL: 1.8% (*CHRIS 1978)
DEL: Not Found
Extinguishing Methods: Extinguish with dry chemicals or carbon
dioxide. Do not use water or foam. Cool exposed containers with water
(*CHRIS 1978). Water spray, fog, or foam may be required to fight large
fires. However, trimethylchlorosilane may react violently with water.
Do not get water inside containers (*DOT 1984).
Special Fire Fighting Procedures: Use acid-vapor-type respirator,
rubber gloves, chemical worker's goggles, and other protective equipment
as necessary to protect skin and eyes (*CHRIS 1978).
Unusual Fire and Explosion Hazards: Violent reaction with water (Sax
1984, p. 2665). Toxic and irritating hydrogen chloride and phosgene may
be formed in fires. Difficult to extinguish, re-ignition may occur.
Flashback along vapor trail may occur. Containers may explode in fire.
Vapor may explode if ignited in enclosed area (*CHRIS 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 895, *CHRIS 1978)
Conditions to Avoid: Avoid contact with water; it readily
hydrolyzes, liberating hydrochloric acid (*Hawley 1977).
Incompatibility (Materials to Avoid): Reacts with surface moisture,
releasing hydrogen chloride, which will corrode common metals and form
flammable hydrogen gas (*CHRIS 1978).
Hazardous Decomposition or Byproducts: When heated to decomposition or
on contact with acids or acid fumes, chloride fumes are emitted (*Sax
1979).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 895)
Conditions to Avoid: Not Found
-------
CAS Registry Number: 75-77-4
Page 3 of 3
TRIMETHYLCHLOROSILANE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Hawley 1977; *Rumack 1975 to Present)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): Similar to other
silanes. Toxicity is rated high for inhalation, ingestion and local
irritation. May cause death or permanent injury after a very short
exposure to small quantities (*Sax 1975).
Signs and Symptoms of Exposure: Inhalation of vapor irritates mucous
membranes. Contact with skin or eye causes severe burns. Ingestion
causes severe burns of mouth and stomach (*CHRIS 1978).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air. If not
breathing give artificial respiration. If breathing is difficult, give
oxygen. Remove and isolate contaminated clothing and shoes. In case of
contact with material, immediately flush skin or eyes with running water
for at least 15 minutes. Keep victim quiet and maintain normal body
temperature (-DOT 1984).
SECTION VI -- USE INFORMATION
Chemical intermediate for silicone fluids silylating agent, and a
component of a catalyst for propylene oxide (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors (see Section V above). In case of spill or leak,
shut off ignition sources; no flares, smoking or flames in hazard area.
Do not touch spilled material. Stop leak if you can do it without risk.
Do not get water inside container. For small spills, take up with sand or
other non-combustible absorbent material and place into container for
later disposal. For large spills, dike far ahead of spill for later
disposal (*DOT 1984).
-------
CAS Registry Number: 75-78-5
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DIMETHYLDICHLOROSILANE
CAS Registry Number: 75-78-5
Synonyms: Dichlorodimethylsilane; Dichlorodimethylsilicon; Inerton
AW-DMCS; Silane, Dichlorodimethyl-
Chemical Formula: C.H,Cl0Si
2 o 2
Molecular Weight: 129.07
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC, inhalation
low
(rat) 4.9 mg/liter/4 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 158°F, 70°C (NFPA 1984, p. 325M-42)
Specific Gravity (H20=l): 1.1 (NFPA 1984, p. 325M-42)
Vapor Pressure (mmHg): 100 at 17.5°C (Weast 1984, p. D-200)
Melting Point: -123°T, -86°C (*CHRIS 1978)
Vapor Density (AIR=1): 4.45 (NFPA 1984, p. 352M-42)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Decomposes (NFPA 1984, p. 325M-42)
Appearance and Odor: Colorless liquid with sharp irritating odor
(*CHRIS 1978).
-------
CAS Registry Number: 75-78-5
Page 2 of 3
DIMETHYLDICHLOROSILANE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 16°F (OC) (*Hawley 1977)
Flammable Limits:
LEL: 3.4% (''-Sax 1975)
UEL: 9.5% (*Sax 1975)
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog, or foam. Move container from fire area if it can be
done without risk. Do not get water inside container. Cool containers
that are exposed to fire from outside until well after fire is out.
Withdraw immediately in case of rising sound from venting safety device or
discoloration of tank due to fire (DOT 1984, Guide 29).
Special Fire Fighting Procedures: Avoid contact with skin, eyes, or
clothing. Wear acid-vapor respirator, rubber gloves, chemical worker's
goggles, other protective and corrosive-resistant equipment as needed
("CHRIS 1978; -Encyc Occupat Health and Safety 1971). Runoff from fire
control or dilution water may cause pollution. Isolate for one-half mile
in all directions if tank car or truck involved in fire (DOT 1984, Guide
29).
Unusual Fire and Explosion Hazards: Vapor may explode if ignited in an
enclosed area; reacts with water to produce irritating and toxic gases
(*CHRIS 1978). Runoff to sewer may create fire or explosion hazard (DOT
1984, Guide 29).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Reacts vigorously with water to
generate hydrogen chloride ("CHRIS 1978).
Hazardous Decomposition or Byproducts: Reacts with water; irritating
gas is produced. Hydrogen chloride and phosgene gases may be formed upon
heating (''"CHRIS 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 75-78-5
Page 3 of 3
DIMETHYLDICHLOROSILANE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-CHRIS 1978)
Skin: Yes (-CHRIS 1978)
Ingestion: Yes (-Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Inhalation irritates
mucous membranes. Severe gastrointestinal damage may occur. Vapors cause
severe eye and lung injury. Upon short contact, second and third degree
burns may occur (-CHRIS 1978).
Signs and Symptoms of Exposure: Inhalation may produce labored
breathing, shortness of breath, chest pain, and pulmonary edema. Severe
irritation results in low blood oxygen. Onset of symptoms following
inhalation of vapors may be delayed for several hours. Contact with
liquid causes severe burns on the skin. Ingestion causes severe burns of
mouth and stomach. Contact with the eye produces severe pain, swelling,
corneal erosions and possible blindness (-Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If breathing is difficult, administer oxygen.
Remove and isolate contaminated clothing and shoes at site. In case of
contact with material, immediately flush skin or eyes with running water
for at least 15 minutes. Keep victim quiet and maintain normal body
temperature (DOT 1984, Guide 29).
SECTION VI -- USE INFORMATION
Chemical introduction for silicone fluids and in ethchlorvynol assays
(-SRI; --AOAC 1965).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact; wear proper respiratory protection, eye
protection and protective clothing (see Section V above). Shut off
ignition sources; no flares, smoking or flames in hazard area. Do not
touch spilled materials; stop leak if you can do so without risk. Use
water spray to reduce vapors; however do not get water inside containers.
Small spills: absorb with sand or other non-combustible absorbent
material and place into containers for later disposal. Large spills:
dike far ahead of spill for later disposal (DOT 1984, Guide 29). Use
effective fume removal device (-AOAC 1965).
-------
CAS Registry Number: 75-79-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- METHYLTRICHLOROSILANE
CAS Registry Number: 75-79-6
Synonyms: Methylsilyl Trichloride; Silane, Methyltrichloro-; Silane,
Trichloromebhyl-; Trichloromethylsilane; Trichloromethylsilicon
Chemical Formula: CH Cl Si
Molecular Weight: 149.48
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC.. inhalation
(rat) 2.75 mg/liter/4 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 152°F, 66.5°C (*Clayton and Clayton 1981-82)
Specific Gravity (H 0=1): 1.2/ at 25°C (*CHRIS 1978)
Vapor Pressure (mmHg): Not Found
Melting Point: -108°F, -77.8°C (Weast 1983, p. C-515)
Vapor Density (AIR=1): 5.17 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Acrid odor, sharp like hydrochloric acid,
colorless liquid (*CHRIS 1978).
-------
CAS Registry Number: 75-79-6
Page 2 of 3
METHYLTRICHLOROSILANE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 45°F (OC); 15°F (CC) (*CHRIS 1978)
Flammable Limits:
LEL: 7.6% (*NFPA 1978)
DEL: 20% (*NFPA 1978)
Extinguishing Methods: Dry chemical or carbon dioxide may be used for
small fires. Water may be used for large fires if firefighters are
protected from violent reaction of methyltrichlorosilane with water.
Water may be used to keep containers cool (*NFPA 1978).
Special Fire Fighting Procedures: Self-contained breathing apparatus
is required as combustion/decomposition yields acid gases/pulmonary
irritants. Corrosion-resistant protective clothing, as well as
appropriate foot, hand, arm, head, eye, and face protection are required
where contact is possible (*Encyc Occupat Health and Safety 1971).
Unusual Fire and Explosion Hazards: Upon thermal decomposition,
hydrogen chloride and phosgene are formed. Reacts with water to form
hydrochloric acid (*CHRIS 1978). Vapor forms flammable mixture with air
(*NFPA 1978). May form explosive mixture in air (*Hawley 1977).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Hawley 1977; *CHRIS 1978)
Stable:
Conditions to Avoid: Contact with water or moist air (*NFPA 1978,
-Sax 1979).
Incompatibility (Materials to Avoid): Reacts with water or steam to
form hydrochloric acid (*CHRIS 1978).
Hazardous Decomposition or Byproducts: Hydrogen chloride and phosgene
formed in fires (*CHRIS 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: .Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (»Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Rumack 1975 to Present)
-------
CAS Registry Number: 75-79-6
Page 3 of 3
METHYLTRICHLOROSILANE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): As with other
chlorosilanes, acute exposures may be highly toxic and may cause death or
permanent injury after very short exposures to small quantitites. Chronic
exposures may be moderately toxic and involve irreversible and reversible
changes (*Sax 1975). Skin contact may produce severe burns with pain and
risk of secondary infections. Ingestion may produce oral, esophageal, and
stomach burns, intensity will vary from mild to very severe,
gastrointestinal damage is rare but may occur ('vRumack 1975 to Present).
Signs and Symptoms of Exposure: The vapor is irritating to nose and
throat and if inhaled will cause difficult breathing. Contact with the
liquid causes severe burns of eyes and skin. Ingestion causes severe
burns of mouth and stomach (*CHRIS 1978). Vomiting may occur. Inhalation
exposures may produce labored breathing, shortness of breath, and
pulmonary edema. Symptoms may be delayed for several hours (*Rumack 1975
to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Remove from exposure, establish
and maintain respiration, irrigate exposed surfaces with copious amounts
of water for at least 15 minutes. Obtain medical attention at once
following exposure to this compound (*Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
Monomer for silicone resins (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Spills can be neutralized by flushing with large quantities of water
followed by treatment with sodium bicarbonate. Provide adequate
protection against generated hydrogen chloride. Do not allow water to get
into container since resulting pressure could cause container to rupture
(*NFPA 1978). Protect against potentially violent reaction with water
(see Section III above). Avoid breathing vapors and contact with skin;
wear proper respiratory protection and protective clothing (see Section V
above).
-------
CAS Registry Number: 75-86-5
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ACETONE CYANOHYDRIN
CAS Registry Number: 75-86-5
Synonyms: 2-Cyano-2-Propanol; 2-Hydroxy-2-Methylpropionitrile;
2-Hydroxyisobutyronitrile; 2-Methyllactonitrile; 2-Propanone, Cyanohydrin;
alpha-Hydroxyisobutyronitrile; Lactonitrile, 2-Methyl-; Propanenitrile,
2-Hydroxy-2-Methyl-; USAF RH-8
Chemical Formula: C.H..NO
4 7
Molecular Weight: 85.10
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC.. inhalation
(rat) 0.116 mg/liter/4 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 180°F, 82°C at 23 mmHg (Weast 1983, p. C-209)
Specific Gravity (H20=l): 0.9267 at 25°C/4°C (*Merck 1976)
Vapor Pressure (nunHg): 0.8 at 20°C (*Clayton and Clayton 1981-82)
Melting Point: -2.2°F, -19°C (*Merck 1976)
Vapor Density (AIR=1): 2.93 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Freely soluble in water (*Merck 1976)
Appearance and Odor: Colorless liquid (*Hawley 1977); distinct strong
cyanide odor (*Lefaux 1968)
-------
CAS Registry Number: 75-86-5
Page 2 of 3
ACETONE CYANOHYDRIN
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 165°F, 74°C (CC) (*NFPA 1978)
Flammable Limits:
LEL: 2.2% (*NFPA 1978)
DEL: 12% (*NFPA 1978)
Extinguishing Methods: Water may cause frothing if it gets below
surface of liquid and turns to steam. Water fog gently applied to surface
will cause frothing which will extinguish fire. Use water spray, dry
chemical, alcohol foam, or carbon dioxide. Use water to keep fire-exposed
containers cool, from a safe distance (*NFPA 1978).
Special Fire Fighting Procedures: Wear air-supplied mask with canister
approved for use with acrylonitrile in less than 2 percent concentration,
rubber or plastic gloves, cover goggles or face mask, rubber boots,
slicker suit, safety helmet (-CHRIS 1978).
Unusual Fire and Explosion Hazards: Too dangerous to health to expose
fire fighters; a few whiffs of vapor could cause death; vapor or liquid
could be fatal on penetrating normal protective clothing. Vapor forms
explosive mixture with air (*NFPA 1978). On contact with sulfuric acid,
it may explode (-Sax 1979).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: Vapor forms explosive mixtures with air
(*NFPA 1978).
Incompatibility (Materials to Avoid): May react violently with water
(*NFPA 1978). Contact with sulfuric acid may cause it to explode (*Sax
1979).
Hazardous Decomposition or Byproducts: Decomposes when heated to 248°F
or at lower temperature under alkaline conditions, emitting highly toxic
hydrogen cyanide (*NFPA 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 75-86-5
Page 3 of 3
ACETONE CYANOHYDRIN
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Patty 1963)
Skin: Yes (-Patty 1963)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): This material is
considered very hazardous and should only be handled under conditions that
prevent any inhalation of vapor or skin contact (*Patty 1963). May be
slightly irritating to skin and mucous membranes (*Merck 1976).
Signs and Symptoms of Exposure: Nausea, loss of consciousness,
convulsions (^Clayton and Clayton 1982); irregular heart beat, headache,
vomiting ("Patty 1963). Slightly irritating to the skin (*Merck 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration
(avoid mouth to mouth resuscitation). If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Speed in removing material
from skin is of extreme importance. Remove and isolate contaminated
clothing and shoes at the site. Keep victim quiet and maintain normal
body temperature. Effects may be delayed; keep victim under observation.
Avoid contact with contaminated skin (DOT 1984, Guide 55; *Rumack 1975 to
Present).
SECTION VI -- USE INFORMATION
Used in the manufacture of insecticides ("Hawley 1977) and as a chemical
intermediate (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material. Use water spray to reduce vapors. Small
spills: take up with sand or other noncombustible absorbent material and
place into containers for later disposal. Large spills: dike far ahead
of spill for later disposal (DOT 1984, Guide 55). Wear air supplied mask
with canister approved for acrylonitrile and full protective clothing
(*CHRIS 1978). Prevent any inhalation of vapor or skin contact (*Patty
1963).
-------
CAS Registry Number: 76-01-7
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PENTACHLOROETHANE
CAS Registry Number: 76-01-7
Synonyms: Ethane Pentachloride; Ethane, Pentachloro-; NCI-C53859; Pentalin
Chemical Formula: C HC1
Molecular Weight: 202.31
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(mouse) 0.035 mg/liter/2 hours (*NIOSH/RTECS 1985)
SECTlbN II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 322°F, 161°C (*Merck 1976)
Specific Gravity (H20=l): 1.6712 at 25°C/4°C (-Merck 1976)
Vapor Pressure (mmHg): 3.4 at 25°C (--Clayton and Clayton 1981-82)
Melting Point: -20°F, -29°C (*Weast 1979)
Vap|or Density (AIR=1): 7.0 ('-Browning 1965)
Evaporation Rate (Butyl acetate=l): 0.03 (ether = 1) (^Browning 1965)
Solubility in Water: 0.05 g/100 ml at 20°C , 68°F (-Clayton and
Clayton 1981-82)
Appearance and Odor: Colorless liquid (*Browning 1965); chloroform-
like odor (*Merck 1976); camphor-like odor (^Browning 1965)
-------
CAS Registry Number: 76-01-7
Page 2 of 4
PENTACHLOROETHANE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Fires should be extinguished using water,
carbon dioxide, or dry chemical ("Sax 1979). Move container from fire
area if you can do so without risk. Fight fire from maximum distance.
Dike fire control water for later disposal; do not scatter the material
(DOT 1984, Guide 55).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: The material is a moderate fire
hazard when exposed to heat or flame and is a moderate explosive hazard by
spontaneous chemical reaction. Dehalogenation by reaction with alkalies,
metals, etc., will produce spontaneous explosive chloroacetylenes.
Violent reactions with (sodium potassium alloy + bromoform) and potassium
occur (Sax 1984, p. 2126).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Pentachloroethane undergoes a
violent reaction with sodium potassium alloy plus bromoform.
Dehalogenation reactions with alkalies and metals will produce spontaneous
explosive chloroacetylenes ("Sax 1979).
Hazardous Decomposition or Byproducts: When heated to decomposition,
the compound emits highly toxic fumes of chlorine containing compounds
(•-Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 76-01-7
Page 3 of 4
PENTACHLOROETHANE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Gosselin 1976)
Skin: Not Found
Ingestion: Yes ("Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): Pentachloroethane is an
irritant and a central nervous system depressant (*Merck 1976). The
chemical^ is very toxic with a probable oral lethal dose of 50-500 rag/kg or
between 1 teaspoon and 1 ounce for a 150 Ib. person ("Gosselin 1976). It
acts as a strong central nervous system depressant (Encyc Occupat Health
and Safety 1983, p. 1078). Death may occur by respiratory arrest or
circulatory collapse (^Gosselin 1976). Pentachloroethane has a strong
narcotic effect. Exposure to this material may also result in injury to
the liver, lungs and kidneys (Clayton and Clayton 1981-82, p. 3520).
Signs and Symptoms of Exposure: Symptoms include prompt nausea,
vomiting, abdominal pain with diarrhea, headaches, dizziness, confusion,
drowsiness, and occasionally convulsions. Visual disturbances may arise
followed by coma and possibly death from respiratory arrest or circulatory
collapse. Occasionally sudden death may occur due to ventricular
fibrillation. Other effects may include weight gain, edema, loss of
appetite, jaundice, and pain (due to enlarged liver) ("Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
It is used as a solvent for oil and grease in metal cleaning and
separation of coal from impurities ("Hawley 1977). The compound is used
to a small extent in dry cleaning and in soil sterilization (^Browning
1965).
-------
CAS Registry Number: 76-01-7
Page 4 of 4
PENTACHLOROETHANE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not breathe vapors. Wear proper respiratory protection (see Section V
above). Do not touch spilled material; stop leak if you can do so without
risk. Use water spray to reduce vapors. Small spills: absorb with sand
or other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clear, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 76-02-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- TRICHLOROACETYL CHLORIDE
CAS Registry Number: 76-02-8
Synonyms: (NIOSH/RTECS 1985 Synonyms On-Line File) Acetyl Chloride,
Trichloro-; Trichloroacetic Acid Chloride; Trichloroacetochloride
Chemical Formula: CC1 COC1
Molecular Weight: 181.83
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(mouse) 0.445 mg/liter (^NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 244°F, 118°C (Hawley 1981, p. 1040)
Specific Gravity (H20=l): 1.654 at 0°C/4°C (Hawley 1981, p. 1040)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Decomposes (Weast 1979, p. C-98)
Appearance and Odor: Liquid (Hawley 1981, p. 1040)
-------
CAS Registry Number: 76-02-8
Page 2 of 4
TRICHLOROACETYL CHLORIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Material may react violently with water.
Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam
(DOT 1984, Guide 59).
Special Fire Fighting Procedures: Move container from fire area if you
can do so without risk. Spray cooling water on containers that are
exposed to flames until well after fire is out. Keep unnecessary people
away; isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Wear positive pressure breathing apparatus and special protective
clothing (DOT 1984, Guide 59).
Unusual Fire and Explosion Hazards: Material may burn but does not
ignite readily. Poisonous if inhaled or swallowed; skin contact
poisonous. Contact may cause burns to skin and eyes (DOT 1984, Guide 59).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 1040)
Skin: Yes (Hawley 1981, p. 1040)
Ingestion: Yes (Hawley 1981, p. 1040)
Health Hazards (Acute, Delayed, and Chronic): Highly toxic by
ingestion and inhalation; strong irritant to skin and tissues (Hawley
1981, p. 1040).
-------
CAS Registry Number: 76-02-8
Page 3 of 4
TRICHLOROACETYL CHLORIDE
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Contact may cause burns to skin and
eyes (DOT 1984, Guide 59).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 59).
SECTION VI -- USE INFORMATION
Not Found
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors (see Section V above). Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand.or other noncombustible
absorbent material and place into containers for later disposal. Large
spills: dike far ahead of spill for later disposal. Keep unnecessary
people away; isolate hazard area and deny entry. Stay upwind; keep out of
low areas. Wear positive pressure breathing apparatus and special .
protective clothing (DOT 1984, Guide 59).
-------
CAS Registry Number: 76-02-8
Page 4 of 4
TRICHLOROACETYL CHLORIDE
COMMENTS
Sources searched but no information found:
NIOSH/RTECS 1983
ACGIH 1983
NIOSH/OSHA 1978
Merck 1983
Sax 1984
NFPA 1984
Student 1981
Weiss 1980
CHRIS 1978
Doull 1980
Clayton and Clayton 1981-82
Arena 1979
Gosselin 1984
Encyc Occupat Health and Safety 1983
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
Oilman 1985
-------
CAS Registry Number: 77-47-4
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- HEXACHLOROCYCLOPENTADIENE
CAS Registry Number: 77-47-4
Synonyms: 1,3-Cyclopentadiene, 1,2,3,4,5,5-Hexachloro-; C 56; Graphlox;
HCCPD; Hexachlorocyclopentadien; Hexachloropentadiene; HRS 1655; NCI-C55607;
PCL; Perchlorocyclopentadiene
Chemical Formula: CCC1,
j D
Molecular Weight: 272.77
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.01 ppm (0.1 mg/m3); STEL 0.03 ppm (0.3 mg/mj)
(*ACGIH 1984)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(mouse, rat) 0.017 mg/liter/7 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 462°F, 239°C at 753 mmHg (*Weast 1984)
Specific Gravity (H20=l): 1.7019 at 25/4°C (*Weast 1984)
Vapor Pressure (mmHg): 0.080 at 25°C (*Clayton and Clayton 1981-82)
Melting Point: 16°F, -9°C (*Weast 1984)
Vapor Density (AIR=1): 9.4 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 800 ppb (*Clayton and Clayton 1981-82)
Appearance and Odor: Yellow-green liquid (*Weast 1984) with a pungent
odor (*Hawley 1981)
-------
CAS Registry Number: 77-47-4
Page 2 of 3
HEXACHLOROCYCLOPENTADIENE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Non-flammable (-Hawley 1981)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Use dry chemical, carbon dioxide, water spray
or foam for small fires. For large fires, use water spray, fog, or foam.
Move hexachlorocyclopentadiene from fire area if this can be done without
risk (*DOT 1984).
Special Fire Fighting Procedures: Isolate hazard area and deny entry.
Wear positive pressure breathing apparatus and special protective
clothing. Fight fire from maximum distance. Dike fire control water for
later disposal (-DOT 1984).
Unusual Fire and Explosion Hazards: Toxic hydrogen chloride, chlorine,
and phosgene gases may form in fires. In presence of moisture, will
corrode iron and other materials; flammable and explosive hydrogen gas may
collect in enclosed space (Weiss 1980, p. 498).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Reacts slowly with water to form hydrochloric
acid; however, the reaction is not hazardous (Weiss 1980, p. 498).
Incompatibility (Materials to Avoid): Will corrode iron and other
metals in the presence of moisture (Weiss 1980, p. 498).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 498)
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Hawley 1981)
Skin: Yes (*Hawley 1981)
Ingestion: Yes (*Hawley 1981)
-------
CAS Registry Number: 77-47-4
Page 3 of 3
HEXACHLOROCYCLOPENTADIENE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): This compound is very
toxic and may be fatal if inhaled, swallowed, or absorbed through the
skin. The probable human lethal dose is 50-500 mg/kg, or between 1
teaspoon and 1 ounce for a 150 Ib. (70 kg) person. Severe exposure
induces pulmonary hyperemia and edema, degenerative and necrotic changes
in brain, heart and adrenal glands and necrosis of liver and kidney
tubules (*DOT 1984; Gosselin 1984, p. 11-169).
Signs and Symptoms of Exposure: Inhalation of mist is highly
irritating to mucous membranes, causing tearing, sneezing, and
salivation. Eye contact may result in severe irritation. Contact of
liquid with the skin may cause blistering and burning (*CHRIS 1978).
Headaches and throat irritation have also been reported as a result of
exposure to this compound (Clayton and Clayton 1981, p. 3751).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with the material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from the skin is of extreme
importance. Keep victim quiet and maintain normal body temperature.
Since effects may be delayed, keep victim under observation (*DOT 1984).
SECTION VI -- USE INFORMATION
Major uses of hexachlorocyclopentadiene include applications as a chemical
intermediate for insecticides and flame retardants (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard and deny entry. Stay upwind
and keep out of low areas. Ventilate closed spaces before entering. Wear
positive pressure breathing apparatus and special protective clothing. Do
not touch spilled material; stop leak if this can be done without risk.
Use water spray to reduce vapors. Absorb small spills with sand or other
noncombustible absorbent material and place into containers for later
disposal. Dike far ahead of large spills for later disposal (*DOT 1984).
-------
CAS Registry Number: 77-78-1
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY - DIMETHYL SULFATE
CAS Registry Number: 77-78-1
Synonyms: Dimethyl Monosulfate; Dimethyl Sulphate; DMS; DMS (Methyl
Sulfate); Methyl Sulfate; Sulfuric Acid, Dimethyl Ester; Dimethylsulfate
Chemical Formula: C ILO^S
Molecular Weight: 126.14
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 1 ppm (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.1 ppm (0.5 mg/m3) (skin) (ACGIH 1985, p. 17)
IDLH: 10 ppm (NIOSH/OSHA 1978, p. 90)
Other Limits Recommended: Industrial substance suspect of carcinogenic
potential for man (ACGIH 1985, p. 42). Toxicity information: LCn
low
inhalation (mouse) 0.39 mg/liter (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: About 370°F, 188°C (with decomposition) (*Merck 1983)
Specific Gravity (H 0=1): 1.3283 at 20°C (*Weast 1979)
Vapor Pressure (mmHg): 0.1 at room temperature (*IARC 1972-1985); 0.5
at 20°C (NIOSH/OSHA 1978, p. 90)
Melting Point: -25.15°F, -31.75°C (*Weast 1979)
Vapor Density (AIR=1): 4.35 (*dayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 2.8 g/100 mL at 18°C (*Merck 1983)
Appearance and Odor: It is a colorless oily liquid (*Merck 1983) with
a faint, onion-like odor (*NFPA 1978)
-------
CAS Registry Number: 77-78-1
Page 2 of 4
DIMETHYL SULFATE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 182°F (CC) (*Hawley 1977)
Flammable Limits: Moderate fire potential when exposed to heat or
flame (*Sax 1975)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: To extinguish small fires use water, foam,
carbon dioxide, and dry chemicals (*Sax 1975). For large fires use water
spray, fog, or foam. Move container from fire area if you. can do it
without risk. Cool containers exposed to flames with water. Fight fire
from a maximum distance (DOT 1984, Guide 57).
Special Fire Fighting Procedures: Wear positive pressure breathing
apparatus and special protective clothing. Dike fire control water for
later disposal. Do not scatter material (DOT 1984, Guide 57).
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-IARC 1972-1985)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Material is normally stable even
under fire exposure conditions and is not hazardously reactive with water
("NFPA 1978). It is incompatible with strong oxidizers and strong ammonia
solutions (NIOSH/OSHA 1978, p. 90).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Sax 1975)
-------
CAS Registry Number: 77-78-1
Page 3 of 4
DIMETHYL SULFATE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Acute: extremely toxic
vapors and liquid --a few whiffs or contact on skin could be fatal (*NFPA
1978). Also acutely toxic if ingested. Delayed effects which are
ultimately fatal may also occur (*Merck 1983). Lethal concentrations as
low as 97 ppm/10 min have been reported in humans. DNA inhibition and
damage to human somatic cells, and sister chromatid exchange in human
fibroblast cells were observed (*NIOSH/RTECS 1985). Delayed appearance
of symptoms may permit unnoticed exposure to lethal quantities (Merck
1983, p. 475).
Signs and Symptoms of Exposure: Immediate effects of vapor exposure
are eye irritation, cough, swelling of tongue, lips, and larynx, and lungs
(later). Ingestion or direct contact with mucous membranes causes
corrosion. Once absorbed, lung damage and liver and kidney injury will
occur (*Dreisbach 1977). Liquid dermal exposure causes blistering,
followed by convulsions, delirium, coma, and death in severe cases (*Merck
1983).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing, start artificial respiration;
if breathing is difficult, give oxygen. If dermal contact occurs,
immediately flush with water for 15 minutes. It is very important to
quickly remove material from skin. Remove and isolate contaminated
clothing and shoes at the site. Keep victim quiet and maintain normal
body temperature. Since effects may be delayed, keep a close watch on the
victim (DOT 1984, Guide 57).
SECTION VI -- USE INFORMATION
Used as a chemical intermediate for quaternary ammonium salts and for
alkylation of phenols and thiols ("SRI), and as a methylating agent in the
manufacture of many organic chemicals (*Merck 1983). Formerly, dimethyl
sulfate was used as a war gas. It is also used in the manufacture of
dyes, perfumes, for the separation of mineral oils, and for the analysis
of auto fluids ("Browning 1965).
-------
CAS Registry Number: 77-78-1
Page 4 of 4
DIMETHYL SULFATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
If spilled in a building, the building must be evacuated and the agent
decomposed by hosing with water or spraying with 5 percent sodium
hydroxide (caustic soda). Workers who enter contaminated area should wear
positive pressure airline hose masks or self-contained breathing
apparatus. Canister-type gas masks,are not safe (*Dreisbach 1977). Wear
special protective clothing (DOT 1984, Guide 57). For large spills,
evaporating vapors can be collected in a chamber with a gas cleaning
device (*NIOSH/OSHA 1981). In case of a small spill or leak (i.e., from a
drum or smaller container or a small leak from a tank), isolate 80 feet in
all directions. In case of a large spill, first isolate 170 feet in all
directions, then evacuate an area 1.4 miles wide and 2.2 miles long in a
downwind direction (DOT 1984, Table of Isolation and Evacuation Distances).
-------
CAS Registry Number: 77-81-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- TABUN
CAS Registry Number: 77-81-6
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 3, p. 127) Phosphoramido-
cyanidic Acid, Dimethyl-, Ethyl Ester; Dimethylamidoethoxyphosphoryl Cyanide;
Dimethylphosphoramidocyanidic Acid, Ethyl Ester; Ethyl Dimethylamidocyano-
phosphate; Ethyl N,N-Dimethylphosphoramidocyanidate; Ethyl N,N-Dimethylamino
Cyanophosphate; GA; LE-100; MCE; T-2104; TL 1578
Chemical Formula: C5HnN202p
Molecular Weight: 162.15
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC.. inhalation
(human) 0.15 mg/liter (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 464°F, 240°C (Merck 1983, p. 1297)
Specific Gravity (H 0=1): 1.073 (U.S. Army 1975, p. 3-2)
Vapor Pressure (mmHg): 0.07 at 25°C (U.S. Army 1975, p. 3-2)
Melting Point: -58°F, -50°C (Merck 1983, p. 1297)
Vapor Density (AIR=1): 5.63 (U.S. Army 1975, p. 3-2)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (Merck 1976, p. 1297).
Appearance and Odor: Colorless to brown liquid; faint fruity odor
(U.S. Army 1975, p. 3-2)
-------
CAS Registry Number: 77-81-6
Page 2 of 3
TABUN
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 172°F (Sax 1984, p. 1335)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Poison A, Liquid) Extinguish
with alcohol foam, carbon dioxide, or dry chemical (Student 1981, p. 56)
Special Fire Fighting Procedures: Complete protection required; have
available decontaminants (bleach, alkali) and atropine (U.S. Army 1975, p.
3-2). Bleaching powder (chlorinated line) destroys Tabun but gives rise
to cyanogen chloride (Merck 1983, p. 1297).
Unusual Fire and Explosion Hazards: Extremely poisonous (Merck 1983,
p. 1297). (Non-Specific -- Poison A, Liquid) Keep away from sparks,
flames, and sources of ignition. Keep out of water sources and sewers
(Student 1981, p. 56).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (U.S. Army 1975, p. 3-3)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Avoid water and acids (U.S. Army
1975, p. 3-2). Can react with oxidizing materials (Sax 1984, p. 1335).
Hazardous Decomposition or Byproducts: Hydrolysis forms hydrogen
cyanide (U.S. Army 1975, p. 3-2). When heated to decomposition, it emits
very toxic fumes of oxides of phosphorus and nitrogen (Sax 1984, p. 1335),
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (U.S. Army 1975, p. 3-2)
Skin: Yes (U.S. Army 1975, p. 3-2)
Ingestion: Yes (U.S. Army 1975, p. 3-2)
-------
CAS Registry Number: 77-81-6
Page 3 of 3
TABUN
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): This material is toxic
by inhalation and by absorption through skin and eyes. The lethal dose
for humans may be as low as 0.01 mg/kg (Merck 1983, p. 1297). Tabun is a
nerve agent; it acts as a cholinesterase inhibitor. The median lethal
dosage (respiratory) is 400 mg-minute/m3 for humans; the median
incapacitating dosage is 300 mg-minute/m3. Respiratory lethal dosages
kill in 1 to 10 minutes; liquid in the eye kills nearly as rapidly. Skin
absorption great enough to cause death may occur in 1 to 2 minutes, but
may be delayed for 1 to 2 hours (U.S. Army 1975, p. 3-3).
Signs and Symptoms of Exposure: Nerve agent symptoms include
difficulty in breathing, drooling, nausea, vomiting, cramps, involuntary
defecation and urination, twitching, jerking, staggering, headache,
confusion, drowsiness, coma, and convulsion. Inhalation causes dimness of
vision and pinpointing of the pupils (U.S. Army 1975, p. 3-2).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: The toxic effects of tabun are
similar to parathion (Sax 1984, p. 1335). First aid for parathion is as
follows: move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Speed in removing material
from skin is of extreme importance. Remove and isolate contaminated
clothing and shoes at the site. Keep victim quiet and maintain normal
body temperature. Effects may be delayed; keep victim under observation
(DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
This material is a chemical warfare agent (Merck 1983, p. 1297).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Poison A, Liquid) When handling, avoid breathing vapors,
keep upwind, wear self-contained breathing apparatus, avoid bodily contact
with the material, wear full protective clothing, and upon skin contact
wash with soap and water (Student 1981, p. 56). Speed in removing
material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes (see Section V above).
-------
CAS Registry Number: 78-00-2
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- TETRAETHYLLEAD
CAS Registry Number: 78-00-2
Synonyms: Lead, Tetraethyl-; NCI-C54988; Plumbane, Tetraethyl-; TEL;
Tetraethyl Lead, Liquid; Tetraethyl Lead; Tetraethylplumbane
Chemical Formula: C0H0-Pb
o ZU
Molecular Weight: 323.45
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: 0.075 mg/mj (*NIOSH/RTECS 1985)
ACGIH TLV: .0.100 rag (lead)/m3; STEL 0.3 mg (lead)/m3 (*ACGIH 1983)
IDLH: 40 mg/m3 (NIOSH/OSHA 1978, p. 176)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: About 392°F, 200°C (*Merck 1983); decomposes between
110 and 200°C (Verschueren 1983, p. 1085)
Specific Gravity (H20=l): 1.653 at 20°C (*Merck 1983)
Vapor Pressure (mmHg): 0.2 at 20°C (*IARC 1972-1985)
Melting Point: -202°F, -130°C (*IARC 1972-1985)
Vapor Density (AIR=1): 8.6 (NFPA 1984, p. 325M-86) (SUSPECT)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*IARC 1972-1985)
Appearance and Odor: Colorless liquid with a pleasant odor (Hawley
1981, p. 1006)
-------
CAS Registry Number: 78-00-2
Page 2 of 3
TETRAETHYLLEAD
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 200°F (no method given) (NFPA 1984, p.
325M-86)
Flammable Limits:
LEL: 1.8 percent by volume (NFPA 1984, p. 325M-86)
UEL: Not Found
Extinguishing Methods: Water spray may be used because the material
can be cooled below its flash point (*NFPA 1978).
Special Fire Fighting Procedures: Fire fighting should be done from an
explosive-resistant location. Use water from unmanned monitors and
hose-holders to keep fire-exposed containers cool. When stopping leak,
use water spray to protect firefighters (*NFPA 1978). Runoff from fire
control or dilution water may cause pollution (*DOT 1984).
Unusual Fire and Explosion Hazards: May explode in fires (*CHRIS 1978)
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*IARC 1972-1985)
Stable:
Conditions to Avoid: Decomposes slowly at room temperature and
more rapidly at elevated temperatures (-IARC 1972-1985).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Venugopal 1978)
Skin: Yes (*Venugopal 1978)
Ingestion: Yes (*Venugopal 1978)
-------
CAS Registry Number: 78-00-2
Page 3 of 3
TETRAETHYLLEAD
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Extremely poisonous; may
be fatal if inhaled, swallowed, or absorbed from the skin. Contact may
cause burns to skin and eyes (*DOT 1984). Most symptoms of poisoning are
due to the effects of tetraethyllead on the nervous system (*Gilman 1980).
Signs and Symptoms of Exposure: Major symptoms of exposure to
tetraethyllead are due to interaction with the central nervous system.
The victim suffers from insomnia, nightmares, anorexia, nausea, vomiting,
headache, weakness, and emotional instability. Subjective central nervous
system symptoms such as irritability, restlessness, and anxiety are next
evident. In the case of intense acute exposure, central nervous system
symptoms progress to delusions, uncoordinated and exaggerated muscle
movements, and finally a maniacal state (*Gilman 1980).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. If contaminated, flush skin with
water. Speed in removing material is of utmost importance. Remove
contaminated clothing. Keep victim quiet and maintain normal body
temperature. Effects may be delayed; keep victim under observation (*DOT
1984).
SECTION VI -- USE INFORMATION
Virtually all of the tetraethyllead produced in the USA is used as an
antiknock additive for gasolines (-IARC 1972-1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Tetraethyllead is hazardous, but areas may be entered with extreme care.
Full protective clothing, including self-contained breathing apparatus,
coats, pants, gloves, boots, and bands around legs, arms, and waist should
be provided. No skin surface should be exposed. Use water spray to
disperse vapors (*NFPA 1978). Outdoors, stay upwind and keep out of low
areas. Isolate hazard area (*DOT 1984).
-------
CAS Registry Number: 78-34-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DIOXATHION
CAS Registry Number: 78-34-2
Synonyms: l,4-Dioxan-2,3-diyl Bis(0,0-Diethyl Phosphorothiolothionate);
l,4-Dioxan-2,3-Diyl 0,0,0',0'-Tetraethyl Di(Phosphorodithioate); 1,4-Dioxane-
2,3-S,S'-Bis(0,0-Diethyl Dithiophosphate); 2,3-Bis(Diethoxyphosphinothioylthio)-
1,4-Dioxane; 2,3-Dioxane S,S-Bis(0,0-Diethylphosphorodithioate); 2,3-
Dioxanedithiol S,S-Bis(0,0-Diethyl Phosphorodithioate); AC 528; Bercotox;
Delnatex; Delnav; Dioxation; Dioxothion; ENT 22,897; Hercules 528; Hercules
AC528; Kavadel; Navadel; NCI-C00395; p-Dioxane-2,3-Dithiol, S,S-Diester with
0,0-Diethyl Phosphorodithioate; p-Dioxane-2,3-diyl Ethyl Phosphorodithioate;
Phosphorodithioic Acid, S,S'-l,4-Dioxane-2,3-diyl 0,0,0',0'-Tetraethyl Ester;
Phosphorodithioic Acid, S,S*-p-Dioxane-2,3-diyl 0,0,0',0'-Tetraethyl Ester;
Ruphos
Chemical Formula: C,0H0,0,P0S.
12 26 624
Molecular Weight: 456.54
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: 0.2 mg/m3 (skin) (ACGIH 1985, p. 17)
IDLH: Not Found
Other Limits Recommended: ADI 0.0015 rag/kg (-Hayes 1975). Toxicity
informi
1985).
information: LC inhalation (mouse) 0.34 mg/liter/1 hour (*NIOSH/RTECS
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 1.257 at 26°C/4°C (''-Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: -4°F, -20°C ('''Merck 1983)
-------
CAS Registry Number: 78-34-2
Page 2 of 4
DIOXATHION
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (-Merck 1983)
Appearance and Odor: Tan liquid (-Merck 1983). (Technical) Brown
liquid (*Martin 1974),
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphorus Pesticide,
Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray,
or foam. Large fires: water spray, fog or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) Stay upwind; keep out of low areas. Ventilate
closed spaces before entering them. Wear positive pressure breathing
apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site. Move container from fire area if you
can do so without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (DOT 1984,
Guide 55).
Unusual Fire and Explosion Hazards: Shock can shatter container,
releasing contents ("Sax 1975). (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) Container may explode in heat of fire. Fire
may produce irritating or poisonous gases. Runoff from fire control water
may give off poisonous gases. Runoff from fire control or dilution water
may cause pollution (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-ACGIH 1979)
Conditions to Avoid: Avoid alkali materials and heat. It is
unstable to iron or tin surfaces and when mixed with certain carriers
(*Martin 1974).
-------
CAS Registry Number: 78-34-2
Page 3 of 4
DIOXATHION
SECTION IV -- REACTIVITY DATA (Continued)
Incompatibility (Materials to Avoid): Avoid alkali materials ("Martin
1974)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes of oxides of nitrogen, phosphorus, and sulfur
(*Sax 1975).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Hawley 1977)
Skin: Yes (Farm Chemicals Handbook 1984, p. C-82)
Ingestion: Yes (--Hawley 1977)
Health Hazards (Acute, Delayed, and Chronic): Very toxic. Probable
oral lethal dose for humans is 50-500 mg/kg or between 1 teaspoonful and 1
oz. for a 70 kg (150 Ib.) person (*Gosselin 1976). It is a cholinesterase
inhibitor ("Hawley 1977). Death is primarily due to respiratory arrest
arising from failure of the respiratory center, paralysis of respiratory
muscles, intense bronchoconstriction, or all three (*Gosselin 1976).
Signs and Symptoms of Exposure: Symptoms are similar to those of
parathion. Nausea is often the first symptom, followed by vomiting,
abdominal cramps, diarrhea, and excessive salivation. Headache,
giddiness, vertigo, and weakness are also common symptoms. Rhinorrhea and
a sensation of tightness in the chest are common in inhalation exposure.
Blurring or dimness of vision, pinpoint pupils, tearing, ciliary muscle
spasm, loss of accommodation, and ocular pain. Also, mental confusion,
disorientation, and drowsiness are experienced ("Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) Move victim to fresh air; call emergency
medical care. If not breathing, perform artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 78-34-2
Page 4 of 4
DIOXATHION
SECTION VI -- USE INFORMATION
Dioxathion is used for control of insects and mites on grapes, citrus,
walnuts, ornamentals, apples, pears, and quince. Also used as a spray or
dip for the control of ticks, lice, hornfly, and sheep ked on cattle,
goats, sheep, and hogs (Farm Chemicals Handbook 1984, p. C-82).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Ventilate closed spaces befre entering them. Wear
positive pressure breathing apparatus and special protective clothing.
Remove and isolate contaminated clothing at the site. Do not touch
spilled material; stop leak if you can do so without risk. Use water
spray to reduce vapors. Small spills: absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 55).
-------
CAS Registry Number: 78-53-5
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- AMITON
CAS Registry Number: 78-53-5
Synonyms: (NIOSH/RTECS SYNONYMS 1983, Volume 3, p. 150)
Phosphorothioic Acid, S-(2-(Diethylamino)Ethyl) 0,0-Diethyl Ester; Chipman
6200; Citram; S-(Diethylaminoethyl) 0,0-Diethyl Phosphorothioate; Diethyl
S-2-Diethylaminoethyl Phosphorothioate; (2-Diethylamino)Ethylphosphorothioic
Acid 0,0-Diethyl Ester; 0,0-Diethyl S-2-Diethylaminoethyl Phosphorothioate;
0,0-Diethyl S-Diethylaminoethyl Phosphorothiolate; 0,0-Diethyl S-2-Diethyl-
aminoethyl Phosphorothiolate; 0,0-Diethyl S-(beta-Diethylaraino)Ethyl
Phosphorothiolate; 0,0-Diethyl S-(2-Diethylaminoethyl) Thiophosphate; DSDP;
ENT 24,980-X; Inferno; Metramac; Metramak; R-5,158; Rhodia-6200; Tetram
Chemical Formula: C,_H-.NO.PS
10 24 3
Molecular Weight: 269.38
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LDcn oral (rat) 3.3
rag/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 230°F, 110°C at 0.2 mm (Sax 1984, p. 1008)
Specific Gravity (H.0=l): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 78-53-5
Page 2 of 4
AMITON
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Not Found
Appearance and Odor: Liquid (Merck 1983, p. 73)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphorus Pesticide,
Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray,
or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) Stay upwind; keep out of low areas. Ventilate
closed spaces before entering them. Wear positive pressure breathing
apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site. Move container from fire area if you
can do so without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (DOT 1984,
Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, can
emit toxic fumes of oxides of nitrogen, phosphorus, and sulfur (Sax 1984,
p. 1009). (Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.)
Container may explode in heat of fire. Fire may produce irritating or
poisonous gases. Runoff from fire control water may give off poisonous
gases. Runoff from fire control or dilution water may cause pollution
(DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Extreme heat (Sax 1984, p. 1009)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Very toxic nitrogen oxides,
phosphorus oxides, and sulfur oxides when heated to decomposition (Sax
1984, p. 1009).
-------
CAS Registry Number: 78-53-5
Page 3 of 4
AMITON
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 1009)
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 1009)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic orally. It is a cholinesterase inhibitor (Sax 1984, p. 1009).
Signs and Symptoms of Exposure: The toxic effects are similar to
parathion (Sax 1984, p. 1009). Symptoms of parathion poisoning include
anorexia, nausea, vomiting, diarrhea, excessive salivation, pupillary
constriction, bronchoconstriction, muscle twitching, convulsions, coma,
respiratory failure. Effects are cumulative (Sax 1984, p. 2119).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Effects are similar to those of
parathion (Sax 1984, p. 1009). First aid procedures for parathion are as
follows: move victim to fresh air; call emergency medical care. If not
breathing, perform artificial respiration. If breathing is difficult,
give oxygen. In case of contact with material, immediately flush skin or
eyes with running water for at least 15 minutes. Speed in removing
material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
This material is used as an acaricide and insecticide (Farm Chemicals
Handbook 1984, p. C222).
-------
CAS Registry Number: 78-53-5
Page 4 of 4
AMITON
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Ventilate closed spaces before entering them.
Wear positive pressure breathing apparatus and special protective
clothing. Remove and isolate contaminated clothing at the site. Do not
touch spilled material; stop leak if you can do so without risk. Use
water spray to reduce vapors. Small spills: absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 55).
-------
CAS Registry Number: 78-71-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- OXETANE, 3,3-BIS(CHLOROMETHYL)-
CAS Registry Number: 78-71-7
Synonyms: (NIOSH/RTECS 1985 Synonyms On-Line File) 3,3-Bis
(Chloromethyl)Oxetane; Penton; 3,3-bis(Chloromethyl)-l-Oxacyclobutane
Chemical Formula: CCH0C100
jo 2
Molecular Weight: 155
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(mouse) 0.2 mg/liter/2 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 217°F, 103°C at 30 mmHg (Beilstein 1974, Volume 17/1,
p. 68)
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 66°F, 19°C (Beilstein 1974, Volume 17/1, p. 68)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Not Found
-------
CAS Registry Number: 78-71-7
Page 2 of 3
OXETANE, 3,3-BIS(CHLOROMETHYL)-
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Not Found
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Not Found
-------
CAS Registry Number: 78-71-7
Page 3 of 3
OXETANE, 3,3-BIS(CHLOROMETHYL)-
SECTION VI -- USE INFORMATION
Penton is the trademark for a thermoplastic resin derived from
3,3-bis(chloromethyl)oxetane. Penton is a liner polymer used for solid
and lined valves, pumps, pipe and fittings, and a monofilament for filter
supports and column packing (Hawley 1981, p. 785).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Not Found
COMMENTS:
Sources searched but no information found:
Weast 1979
Merck 1983
Sax 1984
DOT 1984
NFPA 1984
Student 1981
Weiss 1980
Doull 1980
Clayton and Clayton 1981-82
Encyc Occupat Health and Safety 1983
CHRIS 1978
Hayes 1982
-------
CAS Registry Number: 78-82-0
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ISOBUTYRONITRILE
CAS Registry Number: 78-82-0
Synonyms: 2-Methylpropanenitrile; 1-Cyano-l-Methylethane; 2-Cyanopropane;
2-Methylpropane Nitrile; 2-Methylpropionitrile; Dimethylacetonitrile;
Isopropyl Cyanide; Isopropyl Nitrile; Isopropylcyanide; Propanenitrile,
2-Methyl-; Propanoic Acid, 2-Methyl-, Nitrile
Chemical Formula: C.H..N
4 7
Molecular Weight: 69.1
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Occupational exposure to nitriles --
recommended standard in air: TWA 22 mg/m3 (*NIOSH/RTECS 1985).
Toxicity information: LC. inhalation (rat) 2.82 mg/liter/2 hours
(*NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 219°F, 103.8°C (*Weast 1979)
Specific Gravity (H2
-------
CAS Registry Number: 78-82-0
Page 2 of 4
ISOBUTYRONITRILE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless liquid (*Hawley 1977)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 47°F, 8°C (*NFPA 1978)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, foam, or fog (DOT 1984, Guide 28).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Wear positive pressure breathing apparatus and special protective clothing.
Isolate for 1/2 mile in all directions if tank car or truck is involved in
fire. Move container from fire area if you can do so without risk. Dike
fire control water for later disposal; do not scatter the material. Spray
cooling water on containers that are exposed to flames until well after
fire is out. Withdraw immediately in case of rising sound from venting
safety device or any discoloration of tank due to fire (DOT 1984, Guide
28).
Unusual Fire and Explosion Hazards: Vapor may explode if ignited in an
enclosed area (Weiss 1980, p. 531). Toxic oxides of nitrogen are produced
during combustion (Student 1981, p. 297). It is a flammable/combustible
material and may be ignited by heat, sparks, or flames. Vapors may travel
to a source of ignition and flash back. Container may explode in heat of
fire. Vapor explosion and poison hazard indoors, outdoors or in sewers.
Runoff to sewer may create fire or explosion hazard (DOT 1984, Guide 28).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 531)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of oxides of nitrogen (Sax 1984, p. 1639).
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CAS Registry Number: 78-82-0
Page 3 of 4
ISOBUTYRONITRILE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 531)
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 577)
Skin: Yes (Hawley 1981, p. 577)
Ingestion: Yes (Hawley 1981, p. 577)
Health Hazards (Acute, Delayed, and Chronic): Poisonous; may be fatal
if inhaled, swallowed, or absorbed through skin. Contact may cause burns
to skin and eyes (DOT 1984, Guide 28). (Non-Specific -- Nitriles)
Primarily, they are skin and eye irritants. Large doses cause collapse
and stop breathing (Clayton and Clayton 1981-82, p. 4846).
Signs and Symptoms of Exposure: (Non-Specific -- Nitriles) Exposure
may cause weakness, headache, confusion, nausea, vomiting (Clayton and
Clayton 1981-82, p. 4846), convulsion, dilated pupils, weak pulse, shallow
and gasping breathing and cyanosis (Clayton and Clayton 1981-82, p. 4874).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 28).
SECTION VI -- USE INFORMATION
It is used in organic synthesis (*Patty 1963); as an intermediate for
insecticides (Hawley 1981, p. 577); and as a gasoline additive (Clayton
and Clayton 1981-82, p. 4873).
-------
CAS Registry Number: 78-82-0
Page 4 of 4
ISOBUTYRONITRILE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep sparks, flames, and other sources of ignition away. Keep material
out of water sources and sewers. Build dikes to control flow as
necessary. Attempt to stop leak if this can be done without hazard. Use
water spray to disperse vapors and dilute standing pools of liquid. Avoid
breathing vapors. Keep upwind. Avoid bodily contact with the material.
Wear boots, protective gloves, and goggles. Do not handle broken packages
without protective equipment. Wash away any material which may have
contacted the body with copious amounts of water or soap and water. If
contact with this material is anticipated, wear full protective clothing
(Student, 1981, p. 297). Wear positive pressure breathing apparatus and
special protective clothing. Shut off ignition sources; no flares,
smoking, or flames in hazard area. Do not touch spilled material. Use
water spray to reduce vapors. Small spills: absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 28).
-------
CAS Registry Number: 78-94-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- METHYL VINYL KETONE
CAS Registry Number: 78-94-4
Synonyms: l-Buten-3-one; 2-Butenone; 3-Buten-2-one; 3-Butene-2-one;
Acetone, Methylene-; Acetyl Ethylene; Butenone; Delta(3)-2-Butenone; Gamma-Oxo-
Alpha-Butylene; Ketone, Methyl Vinyl; Methylene Acetone; Methylvinyl Ketone;
Vinyl Methyl Ketone
Chemical Formula: C.H.O
4 6
Molecular Weight: 70.09
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat) 0.007 mg/liter/4 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 179°F, 81.4°C (*Merck 1983)
Specific Gravity (H20=l): 0.8636 at 20/4°C; 0.8407 at 25/4°C (*Merck
1983)
Vapor Pressure (mmHg): Not Found
Melting Point: 20°F, -7°C (*CHRIS 1978)
Vapor Density (AIR=1): 2.41 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 78-94-4
Page 2 of 4
METHYL VINYL KETONE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Soluble (*Merck 1983)
Appearance and Odor: Colorless liquid (*Hawley 1981) with pungent odor
(*Merck 1983)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 20°F, -6.6°C (CC) (*Hawley 1981);
30°F, -1.1°C (OC) (*CHRIS 1978)
Flammable Limits:
LEL: 2.1% (*NFPA 1978)
DEL: 15.6% (*NFPA 1978)
Extinguishing Methods: Use dry chemical, alcohol foam, or carbon
dioxide. Water spray may be ineffective as an extinguishing agent (*NFPA
1978). Small fires: dry chemical, carbon dioxide, and foam. Large
fires: fog or foam. Move container from fire area if you can do so
without risk. Dike fire control water for later disposal; do not scatter
the material. Spray cooling water on containers that are exposed to
flames until well after fire is out. Withdraw immediately in case of
rising sound from venting safety device or any discoloration of tank due
to fire (DOT 1984, Guide 28).
Special Fire Fighting Procedures: Use water to keep fire-exposed
containers cool ("NFPA 1978). Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas. Wear
positive pressure breathing apparatus and special protective clothing.
Isolate for 1/2 mile in all directions if tank car or truck is involved in
fire (DOT 1984, Guide 28).
Unusual Fire and Explosion Hazards: Vapors form flammable mixtures
with air, and may travel a considerable distance to a source of ignition
and flash back. Polymerization may take place in containers, possibly
with violent rupture of containers (*NFPA 1978). Upon exposure to heat or
flame, it emits toxic and irritating fumes (*Sax 1979). Container may
explode in heat of fire. Vapor explosion and poison hazard indoors,
outdoors, or in sewers (DOT 1984, Guide 28).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: Polymerizes on standing (*Merck 1983)
-------
CAS Registry Number: 78-94-4
Page 3 of 4
METHYL VINYL KETONE
SECTION IV -- REACTIVITY DATA (Continued)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Yes (*NFPA 1978)
May Not Occur:
Conditions to Avoid: Heat or sunlight (*NFPA 1978)
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Similar to other ketones) (*Rumack
1975 to Present)
Skin: Yes (-Merck 1983)
Ingestion: Yes (*DOT 1984)
<
Health Hazards (Acute, Delayed, and Chronic): This material is readily
absorbed through the skin, causing general poisoning (*Merck 1983) similar
to other ketones; inhalation has central nervous system depressant effects
(*Rumack 1975 to Present). It is irritating to mucous membranes and
respiratory tract (*Merck 1983) and to the skin; it is a lachrymator and
can cause eye injury (*Grant 1974).
Signs and Symptoms of Exposure: Liquid or high concentration of vapors
causes blistering of the skin (*NFPA 1978). Similar to other ketones; can
cause sore throat, sneezing, coughing, and salivation. Inhalation may
cause nausea and vomiting; inhalation of high concentrations can cause
headache, dizziness, fainting, tremor, uncoordination, lowered body
temperature, depressed respiratory and heart rate, gasping, coma, and
death. Direct aspiration of liquid into lungs can cause chemical
pneumonia. (*Rumack 1975 to Present)
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at site. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (*DOT 1984).
-------
CAS Registry Number: 78-94-4
Page 4 of 4
METHYL VINYL KETONE
SECTION VI -- USE INFORMATION
This material is used as an alkylating agent, a starting material for
plastics, and an intermediate in the synthesis of steroids and Vitamin A
(*Merck 1983).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors (see Section V above). Isolate area. Stay upwind;
keep out of low areas. Wear positive pressure breathing apparatus and
special protective clothing. Shut off ignition sources; no flares,
smoking, or flames in hazard area. Do not touch spilled material; stop
leak if you can do so without risk. Use water spray to reduce vapors.
Absorb small spills with sand or other noncombustible absorbent material
and place into containers for later disposal. For large spills, dike far
ahead for later disposal (*DOT 1984).
-------
CAS Registry Number: 78-97-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- LACTONITRILE
CAS Registry Number: 78-97-7
Synonyms: 2-Hydroxypropanenitrile; 2-Hydroxypropionitrile; Acetaldehyde
Cyanohydrin; Acetocyanohydrin; alpha-Hydroxypropionitrile; Ethylidene
Cyanohydrin; Propanenitrile, 2-Hydroxy-; Propanoic Acid, 2-Hydroxy-, Nitrile
Chemical Formula: C H NO
Molecular Weight: 71
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(rat) 0.36 mg/liter/4 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 360-363°F, 182-184°C; slight decomposition (Weast 1979,
p. C-456)
Specific Gravity (H20=l): 0.9877 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): 10 at 74°C (*Patty 1963)
Melting Point: -40°F, -40°C (*Weast 1979)
Vapor Density (AIR=1): 2.45 (*NFPA 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in all proportions (*Weast 1979)
Appearance and Odor: Straw colored liquid (*Patty 1963)
-------
CAS Registry Number: 78-97-7
Page 2 of 3
LACTONITRILE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 170°F (TCC) (Sax 1984, p. 1683)
Flammable Limits: Moderate when exposed to heat or flame (*Encyc
Occupat Health and Safety 1971)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Foam, carbon dioxide, dry chemical (Sax 1984,
p. 1683).
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Cyanide fumes released when heated
to decomposition (*Encyc Occupat Health and Safety 1971).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Alkali (*Hawley 1977); oxidizing
material (Sax 1984, p. 1683).
Hazardous Decomposition or Byproducts: Cyanide fumes when heated to
decomposition ("Encyc Occupat Health and Safety 1971); hydrocyanic acid in
presence of alkali (*Hawley 1977).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes ("Encyc Occupat Health and Safety
1971)
Skin: Yes (*Encyc Occupat Health and Safety 1971)
Inqestion: Yes ("Encyc Occupat Health and Safety
1971)
-------
CAS Registry Number: 78-97-7
Page 3 of 3
LACTONITRILE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic by oral,
skin, or eye contact (*Patty 1963)
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Treat as cyanide poisoning. Get
emergency medical treatment immediately. If there is exposure through
skin contact, wash with soap and water. Exposed eyes should be flushed
copiously with water for at least 15 minutes. If the victim stops
breathing before emergency medical treatment is available, give artificial
respiration or oxygen, but avoid mouth to mouth respiration; also avoid
contact with contaminated skin (*Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
Solvent -- intermediate in production of ethyl lactate and lactic acid
(-Hawley 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not breathe vapors or touch spilled material. Wear proper respiratory
protection, eye protection and full protective clothing (see Section V
above).
-------
CAS Registry Number: 79-06-1
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ACRYLAMIDE
CAS Registry Number: 79-06-1
Synonyms: 2-Propenamide; Acrylic Amide; Ethylene Carboxamide; PropenamideJ
Propenoic Acid, Amide
Chemical Formula: C H NO
Molecular Weight: 71.08
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 0.3 mg/m3 (skin) (OSHA 1984, p. 660)
ACGIH TLV: TWA 0.3 mg/m3; STEL 0.6 mg/m3 (skin) (*ACGIH 1981)
IDLH: Not Found
Other Limits Recommended: It is recommended that no more than 0.05
mg/kg/day be absorbed by workers ("ACGIH 1980). Suspected of carcinogenic
potential in humans; notice of intent to change to 0.03 mg/m3 for
1985-86 (ACGIH 1985, p. 42).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 189°F, 87°C at 2 mmHg (-Merck 1976)
Specific Gravity (H20=l): 1.122 at 30°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 0.007 at 20°C (*ACGIH 1980)
Melting Point: 184°F, 84.5°C (*Merck 1976)
Vapor Density (AIR=1): 2.45 (*Sax 1975)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 215.5 g/100 mL water at 30°C (*Merck 1976)
Appearance and Odor: Odorless (*Grant 1974) white, crystalline solid
(*Sax 1975).
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CAS Registry Number: 79-06-1
Page 2 of 4
ACRYLAMIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 138°C (CC) (*Sunshine 1969)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: For small fires, use dry chemical, carbon
dioxide, water spray or foam. For large fires use water spray, fog or
foam. Move container from fire area if you can do so without risk (*DOT
1984).
Special Fire Fighting Procedures: Fight fire from maximum distance.
Dike fire control water for later disposal; do not scatter the material
(•-DOT 1984).
Unusual Fire and Explosion Hazards: Heating to decomposition evolves
ammonia, hydrogen and carbon monoxide (*Rumack 1975 to Present).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Hawley 1977)
Conditions to Avoid: Heat (-ACGIH 1980); ultraviolet light (*Merck
1976).
Incompatibility (Materials to Avoid): Strong oxidizers (NIOSH/OSHA
1978, p. 42).
Hazardous Decomposition or Byproducts: Pure acrylamide will decompose
at 175-300°C giving ammonia, hydrogen and carbon monoxide (*Rumack 1975 to
Present).
Hazardous Polymerization: May Occur: Yes (*ACGIH 1980)
May Not Occur:
Conditions to Avoid: It readily polymerizes when heated to the
melting point or when exposed to ultraviolet light (*Merck 1976). It
is known to polymerize with violence when heated ("ACGIH 1980).
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (NIOSH/OSHA 1978, p. 43)
Skin: Yes (''-Hamilton 1974)
Ingestion: Yes (NIOSH/OSHA 1978, p. 43)
-------
CAS Registry Number: 79-06-1
Page 3 of 4
ACRYLAMIDE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Classified as very
toxic; probable oral lethal human dose is between 50 and 500 rag/kg or
between 1 teaspoon and 1 ounce for a 150 Ib. person (Gosselin 1984, p.
11-409). Polymerized acrylamide is not toxic, but the monomer can cause
peripheral nerve damage (*Doull 1980). It is a cumulative neurotoxin and
repeated exposure to small amounts may cause serious injury to the nervous
system (*Rumack 1975 to Present). The neurological effects may be
delayed. Polymer inhibitors or stabilizers added to the monomer may also
produce toxicity ('vPeer Review Committee). The symptoms of acrylamide
toxicity are consistent with mid-brain lesions (""Hamilton 1974) and
blocked transport along both motor and sensory axons (*Doull 1980).
Signs and Symptoms of Exposure: Complaints of drowsiness, fatigue,
tingling of fingers, and a stumbling, propulsive type of walking with
sense of unsteadiness have been reported ("Patty 1963). Motor and sensory
impairment, numbness, tremor, abnormal feelings in the lower limbs
accompanied by weakness, and speech disturbances were also reported
('•Hamilton 1974).
Medical Conditions Generally Aggravated by Exposure: Individuals with
nervous system diseases should not be exposed to acrylamide ("Plunkett
1976).
Emergency and First Aid Procedures: Move victim to fresh air. If not
breathing give artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, wash skin or eyes with running
water. Speed in removing material from the skin is of extreme
importance. Remove contaminated clothing, keep victim quiet and maintain
normal body temperature. Effects may be delayed, keep victim under
observation (-DOT 1984).
SECTION VI -- USE INFORMATION
Reactive monomer and intermediate in production of organic chemicals,
polymers or copolymers ("ACGIH 1980); the latter are used as or in
flocculants for sewage and waste treatment; soil conditioning agents; ore
processing; adhesives; paper and textile industries; permanent press
fabrics (*Hawley 1977).
-------
CAS Registry Number: 79-06-1
Page 4 of 4
ACRYLAMIDE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Wear positive pressure breathing apparatus and special protective
clothing. Remove and isolate contaminated clothing at the site. Do not
touch spilled material; stop leak if you can do so without risk. Use
water spray to reduce vapors. Small spills: absorb with sand or other
non-combustible absorbent materal and place into containers for later
disposal. Small dry spills: with clean shovel place material into clean,
dry container and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal (-DOT 1984).
-------
CAS Registry Number: 79-11-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY - CHLOROACETIC ACID
CAS Registry Number: 79-11-8
Synonyms: Acetic Acid, Chloro-; alpha-Chloroacetic Acid; Chloracetic Acid;
Chloroethanoic Acid; MCA; MKHUK; Monochloracetic Acid; Monochloroacetic Acid;
Monochloroacetic Acid Solution; Monochloroethanoic Acid; NCI-C60231
Chemical Formula: C H CIO
Molecular Weight: 94.50
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat) 0.160 mg/liter (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 372°F, 189°C (*Merck 1976)
Specific Gravity (H 0=1): 1.4043 at 40°C (*Weast 1979)
Vapor Pressure (mmHg): 1 at 43°C (*Patty 1963)
Melting Point: 145°F, 63°C (*Weast 1979)
Vapor Density (AIR=1): 3.26 (*Sax 1975)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very soluble in water (*Weast 1979)
Appearance and Odor: Colorless or white crystals (*Merck 1976).
Colorless to light brown crystals (*Hawley 1977).
-------
CAS Registry Number: 79-11-8
Page 2 of 4
CHLOROACETIC ACID
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 302°F, 150°C (*NFPA 1978)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Water fog applied gently to surface will cause
frothing which will extinguish fire. Normal fire fighting procedures may
be used (-NFPA 1978). Extinguish fire using agent suitable for
surroundings. Material itself does not burn or burns with difficulty.
(^Student 1981) For small fires use dry chemical, carbon dioxide, water
spray or foam. For large fires use water spray, fog, or foam ("DOT 1984).
Special Fire Fighting Procedures: This material is extremely hazardous
to health, but fire fighters may enter areas with extreme care. Full
protective clothing including a self-contained breathing apparatus, coat,
pants, gloves, boots and bands around legs, arms and waist should be
provided. No skin surface should be exposed (*NFPA 1978). Cool
fire-exposed containers with water (^Student 1981). Move container from
fire area if you can do so without risk. Spray cooling water on
containers that are exposed to flames until well after fire is out ("DOT
1984).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits highly toxic fumes of phosgene and chlorides ("Sax 1975). Water may
cause frothing if it gets below surface of the liquid and turns to steam
(*NFPA 1978). Flammable/poisonous gases may accumulate in tanks and
hopper cars. Some of these materials may ignite combustibles, e.g., wood,
paper, oil (*DOT 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Heating (*Sax 1975)
Incompatibility (Materials to Avoid): It is corrosive to metals
(^Student 1981).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes of phosgene and chlorides (*Sax 1975).
-------
CAS Registry Number: 79-11-8
Page 3 of 4
CHLOROACETIC ACID
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Encyc Occupat Health and Safety 1971)
Ingestion: Yes (*Encyc Occupat Health and Safety
1971)
Health Hazards (Acute, Delayed, and Chronic): This material is very
toxic. The probable lethal oral dose is 50-500 mg/kg of body weight,
between one teaspoon and one ounce, for a 150 Ib. person. Chloroacetic
acid is irritating to the skin, cornea, and respiratory tract and causes
burns. It may severely damage skin and mucous membranes. Ingestion may
interfere with essential enzyme systems and cause perforation and
peritonitis. Burns to skin result in marked fluid and electrolyte loss.
Death may follow if more than 3% of the skin is exposed to this material.
Other health hazards include central nervous system depression, and
respiratory system depression (*Rumack 1975 to Present).
Signs and Symptoms of Exposure: Irritation and pain in skin. If
chloroacetic acid is inhaled the patient may exhibit difficulty in
breathing. Vomiting may occur if the material is ingested. It can burn
the skin, cornea and respiratory tract (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Persons with lung
diseases are at greater risk (*ITI 1982).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency care. Remove and isolate contaminated clothing and shoes at
site. If contact occurs with the material, flush skin or eyes with
running water for at least 15 minutes. Keep victim quiet and maintain
normal body temperature (*DOT 1984)
-------
CAS Registry Number: 79-11-8
Page 4 of 4
CHLOROACETIC ACID
SECTION VI -- USE INFORMATION
Chloroacetic acid is used as a pre-emergence herbicide. It is also used
as a defoliant (*Martin and Worthing 1974). It is an intermediate for
synthetic caffeine (*NIOSH 1984) as well as sarcosine, EDTA, and
ethylchloroacetate (*ITI 1982) and sodium carboxymethylcellulose, glycine,
thioglycolic acid, Pharmaceuticals like Vitamin A and indigoid dyes (*SRI)
Additional uses include disinfectant and as a drying agent for curing hay
(USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Neutralize spilled materials with crushed limestone, soda ash, or lime
(^Student 1981). Waste water containing chloroacetic acid can be treated
with ammonia, ammonium salts, or amines followed by separation of
suspended solids (*0pavsky 1976). Keep unnecessary people away; isolate
hazard and deny entry. Stay upwind; keep out of low areas. Wear
self-contained breathing apparatus and full protective clothing. Notify
authorities if water pollution occurs. Do not touch spilled material.
Stop leak if you can without risk. Take up small spills with an
absorbent, non-combustible material and place into clean, dry containers
for later disposal. Dike large spills far ahead of spill for later
disposal (*DOT 1984).
-------
CAS Registry Number: 79-19-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- THIOSEMICARBAZIDE
CAS Registry Number: 79-19-6
Synonyms: l-Amino-2-Thiourea; 1-Aminothiourea; 2-Thiosemicarbazide;
Aminothiourea; Hydrazinecarbothioamide; Isothiosemicarbazide; N-Aminothiourea;
Thiocarbamoylhydrazine
Chemical Formula: CH N S
Molecular Weight: 91.15
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (rat)
9.16 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 356-363°F, 180-184°C (*Hawley 1977)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (*Hawley 1977)
Appearance and Odor: This compound is a white crystalline powder and
is odorless.(*Hawley 1977) . .
-------
CAS Registry Number: 79-19-6
Page 2 of 3
THIOSEMICARBAZIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Poisonous, Solid, n.o.s)
Extinguish with any chemical, carbon dioxide, water spray, fog, or foam
(DOT 1984, Guide 53).
Special Fire Fighting Procedures: (Non-specific -- Poisonous, Solid,
n.o.s.) Stay upwind; keep out of low areas. Wear self-contained
(positive pressure if available) breathing apparatus and full protective
clothing. Move container from fire area if you can do so without risk
(DOT 1984, Guide 53).
w
Unusual Fire and Explosion Hazards: When heated to decomposition, very
toxic fumes of sulfur oxides and nitrogen oxides are emitted (Sax 1984, p.
2575).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
thiosemicarbazide emits very toxic fumes of oxides of sulfur and nitrogen
(Sax 1984, p. 2575).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 2575)
-------
CAS Registry Number: 79-19-6
Page 3 of 3
THIOSEMICARBAZIDE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic by ingestion (Sax 1984, p. 2575). May induce goiter and cause
delayed toxic effects in blood and skin ("Rumack 1975 to Present). May be
mutagenic in human cells (»NIOSH/RTECS 1985).
Signs and Symptoms of Exposure: Thiosemicarbazide may induce goiter
and has also been reported to cause bone marrow depression with
accompanying decreases in white blood cells and platelets. It may also
cause slcin irritation (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: For inhalation, remove victim to
fresh air and monitor for breathing difficulty. For eye exposure,
irrigate copiously with water for 15 minutes and follow with eye exam if
pain persists. For dermal exposure, wash skin twice with water and soap,
followed by exam if pain persists (•"Rumack 1975 to Present).
(Non-Specific -- Poisonous, Solid, n.o.s.) Call emergency medical care.
Remove and isolate contaminated clothing and shoes at the site (DOT 1984,
Guide 53).
SECTION VI -- USE INFORMATION
This compound is used as a reagent for ketones and certain metals, for
photography and as a rodenticide (*Hawley 1977). It is also effective for
control of bacterial leaf blight of rice ('"Nippon Noyaku Gakkaishi 1976,
1(2)95). Not a registered pesticide in the U.S. (USEPA/Active
Ingredients, 1985). It is a chemical intermediate for herbicides and a
reagent for detection of metals ("SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid skin contact, ingestion or inhalation (see Section V above).
(Non-Specific -- Poisonous, Solid, n.o.s.) Do not touch spilled material;
stop leak if you can do it without risk. Small spills: take up with sand
or other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53).
-------
CAS Registry Number: 79-21-0
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- PERACETIC ACID
CAS Registry Number: 79-21-0
Synonyms: Peroxyacetic Acid; Acetyl Hydroperoxide; Hydroperoxide, Acetyl;
Peracetic Acid Solution (Sax 1984, p. 2148); Ethaneperoxoic Acid (Merck 1983,
p. 1028)
Chemical Formula: C2H4°3
Molecular Weight: 76.05
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC n inhalation
(rat) 0.45 mg/liter (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 221°F, 105°C (-Weast 1979)
Specific Gravity (H 0=1): 1.226 at 15°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: 32°F, 0.1°C (*Weast 1979); approximately -22°F, -30°C
(Hawley 1981, p. 786)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very soluble (*Weast 1979)
Appearance and Odor: Colorless liquid (*NFPA 1978). Strong, pungent
acrid odor (*CHRIS 1978, *Merck 1983).
-------
CAS Registry Number: 79-21-0
Page 2 of 3
PERACETIC ACID
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): (Peracetic Acid, 60% Acetic Acid Solution)
105°F, 41°C (no method given) (NFPA 1984, p. 49-72)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Fight fires from an explosion-resistant
location. In advanced or massive fires, area should be evacuated (NFPA
1984, p. 49-72). For small fires: use dry chemical, carbon dioxide,
water spray, or foam. For large fires: flood area with water (DOT 1984,
Guide 51).
Special Fire Fighting Procedures: If fire occurs in the vicinity of
this compound, water should be used to keep containers cool. Cleanup and
salvage operations should not be attempted until all of the peroxyacetic
acid solution has cooled completely (NFPA 1984, p. 49-72). Keep
unnecessary people away; wear self-contained breathing apparatus and full
protective clothing (DOT 1984, Guide 51).
Unusual Fire and Explosion Hazards: Decomposes violently at 230°F,
•110°C (NFPA 1984, p. 325M-78). When heated to decomposition, this
compound emits acrid smoke and fumes (Sax 1984, p. 2148). Runoff to sewer
may create a fire or explosion hazard (DOT 1984, Guide 51).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (NFPA 1984, p. 49-72)
Stable:
Conditions to Avoid: Shock and heat (NFPA 1984, p. 49-72).
Incompatibility (Materials to Avoid): Powerful oxidizer. Isolate from
other stored material, particularly accelerators, oxidizers, and organic
or flammable materials (NFPA 1984, p. 49-72).
Hazardous Decomposition or Byproducts: Emits acrid smoke and fumes
when heated to decomposition (Sax 1984, p. 2148).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (NFPA 1984, p. 49-72)
Conditions to Avoid: Not Found
-------
CAS Registry Number: 79-21-0
Page 3 of 3
PERACETIC ACID
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*NFPA 1978)
Skin: Yes (Sax 1984, p. 2148)
Ingestion: Yes (*Gosselin 1984)
Health Hazards (Acute, Delayed, and Chronic): This is a very toxic
compound. The probable human oral lethal dose is 50-500 mg/kg, or between
1 teaspoon and 1 ounce for a 150 pound person (*Gosselin 1984).
Signs and Symptoms of Exposure: Inhalation causes severe irritation of
mucous membranes. Contact with liquid causes severe irritation of eyes
and skin. Ingestion causes severe distress, including burns of the mouth
and stomach (Weiss 1982, p. 737).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If victim is not breathing apply artificial
respiration and give oxygen. Remove and isolate contaminated clothing.
In case of contact with material, immediately flush eyes with running
water for at least 15 minutes; wash skin with soap and water. Keep victim
quiet and maintain normal body temperature. If material is ingested, give
plenty of warm water (DOT 1984, Guide 51; Weiss 1982, p. 730).
SECTION VI -- USE INFORMATION
This compound is used as a bactericide and fungicide, especially in food
processing; a reagent in making caprolactam and glycerol; an oxidant for
preparing epoxy compounds; a bleaching agent; a sterilizing agent; and a
polymerization catalyst for polyester resins (-Hawley 1981; "'SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors. Wear proper respiratory protection, eye
protection, and full protective clothing (see Section V above). Do not
touch the spilled material; shut off all ignition sources and stop the
leak if this can be done without risk (DOT 1984, Guide 51). The spilled
material should be absorbed with a noncombustible absorbent such as
vermiculite. Sweep up and place in a metal container for immediate
disposal. Do not use spark-generating metals or organic materials for
sweeping up or handling spilled material. Dispose of the absorbed
peroxyacetic acid solution, in small quantities at a time, by placing it
on the ground in a remote outdoor area and igniting with a long torch.
Empty containers should be washed with a 10% sodium hydroxide solution
(NFPA 1984, p. 49-72).
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CAS Registry Number: 79-22-1
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- METHYL CHLOROFORMATE
CAS Registry Number: 79-22-1
Synonyms: Carbonochloridic Acid, Methyl Ester; Chlorocarbonic Acid, Methyl
Ester; Chloroformic Acid Methyl Ester; Formic Acid, Chloro-, Methyl Ester;
K-Stoff; Methoxycarbonyl Chloride; Methyl Chlorocarbonate; TL 438
Chemical Formula: C H CIO
Molecular Weight: 94.50
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(cat) 1.5 mg/liter/30 minutes (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 160°F, 71.0°C (-Merck 1976)
Specific Gravity (H20=l): 1.223 at 20°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): 3.26 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (Sax 1984, p. 1826)
Appearance and Odor: Clear liquid (*Merck 1976)
-------
CAS Registry Number: 79-22-1
Page 2 of 3
METHYL CHLOROFORMATE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 54°F (no method given) (*Sax 1979)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: For small fires, use dry chemical, carbon
dioxide, water spray, and foam. For large fires, use water spray, fog, or
foam. Move container from fire area if it can be done without risk. Cool
containers exposed to flames with water (DOT 1984, Guide 28).
Special Fire Fighting Procedures: Isolate for 1/2 mile in all
directions if tank car or truck is involved in fire. Wear positive
pressure breathing apparatus and special protective clothing (DOT 1984,
Guide 28).
Unusual Fire and Explosion Hazards: This chemical is very dangerous
when exposed to heat sources, sparks, flame, or oxidizers. It will react
with water or steam to produce toxic and corrosive fumes ("Sax 1979).
Vapors may travel to a source of ignition and flash back. Withdraw
immediately in case of rising sound from venting safety device or any
discoloration of tank due to fire (DOT 1984, Guide 28).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Heat or steam should be avoided (*Sax 1979).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Toxic fumes of phosgene are
produced when the material is heated to decomposition. Will react with
water or steam to produce toxic and corrosive fumes (*Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1826)
Skin: Yes (Sax 1984, p.1826)
Ingestion: Yes (Sax 1984, p. 1826)
-------
CAS Registry Number: 79-22-1
Page 3 of 3
METHYL CHLOROFORMATE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Methyl chloroformate is
highly toxic upon inhalation and upon ingestion ("Merck 1976; Sax 1984, p.
1826). A concentration of 1 mg/liter (190 ppm) has been lethal in 10
minutes (^Clayton and Clayton 1981-82). It is corrosive and irritating to
skin (*Hawley 1977).
Signs and Symptoms of Exposure: It is an irritant to the skin and is
corrosive by ingestion or inhalation. Concentrations of 10 ppm have
caused lachrymation and a concentration of 190 ppm for 10 minutes has been
lethal to humans. Irritation of the lung and eyes may persist after
cessation of exposure. Skin allergies may also occur (*Clayton and
Clayton 1981-82). After 2-3 inhalations, brief initial irritation may
occur followed by massive symptoms (heavy cough) after 36 hours. Relapses
may occur in following days with eventual full recovery (••Schuckmann 1972).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing, give artificial respiration; if
breathing is difficult, provide oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact, immediately flush
skin or eyes with water for at least 15 minutes. Keep victim quiet and
maintain normal body temperature. Since effects may be delayed, keep
careful watch on the victim (DOT 1984, Guide 28).
SECTION VI --USE INFORMATION
Methyl chloroformate is used in organic synthesis and in manufacturing of
insecticides (*Hawley 1977). It was used as a warfare agent during World
War I (*Clayton and Clayton 1981-82).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors and contact with skin. Wear proper respiratory
protection, goggles and protective clothing. In case of contact,
immediately flush skin or eyes with water. Remove and isolate
contaminated clothing (see Section V above). Runoff from fire control or
dilution water should be contained for later disposal. In case of a small
spill, take up with sand or other noncombustible absorbent material and
place in containers for later disposal. In case of a large spill, dike
far ahead of the spill for later disposal. In case of spills or leaks,
shut off ignition sources, and have no flares, smoking, or flames in
hazard area. Do not touch spilled material and use water spray to reduce
vapors (DOT 1984, Guide 28).
-------
CAS Registry Number: 80-63-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- METHYL 2-CHLOROACRYLATE
CAS Registry Number: 80-63-7
Synonyms: 2-Chloroacrylic Acid, Methyl Ester; 2-Propenoic Acid, 2-Chloro-,
Methyl Ester; Acrylic Acid, 2-Chloro-, Methyl Ester; Methyl
Alpha-Chloroacrylate; Propenoic Acid, 2-Chloro-, Methyl Ester
Chemical Formula: C.H CIO
Molecular Weight: 120.54
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat) 0.5 mg/liter/2 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 126°F, 52°C at 51 mmHg (*Weast 1979)
Specific Gravity (H20=l): 1.189 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Colorless liquid (*Lefaux 1968)
-------
CAS Registry Number: 80-63-7
Page 2 of 3
METHYL 2-CHLOROACRYLATE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Poisonous Liquid, n.o.s.)
Small fires: dry chemical, carbon dioxide, water spray, or foam. Large
fires: water spray, fog, or foam. Move container from fire area if you
can do so without risk (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Fight fire from maximum distance.
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Wear positive pressure breathing apparatus and special protective
clothing (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Lefaux 1968)
Skin: Yes (*Lefaux 1968)
Ingestion: Not Found
-------
CAS Registry Number: 80-63-7
Page 3 of 3
METHYL 2-CHLOROACRYLATE
Health Hazards (Acute, Delayed, and Chronic): It is a skin, eye, and
lung irritant. The least trace on skin raises large blisters. It is also
a respiratory poison; breathing the vapors can cause pulmonary edema
(*Lefaux 1968).
Signs and Symptoms of Exposure: A trace on skin causes large
blisters. Inhalation of high concentrations may cause rapid breathing,
headache, nausea, lethargy, pulmonary edema, convulsions, and death
(Gosselin 1984, p. 11-409).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Poisonous Liquid,
n.o.s.) Move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. Remove and isolate contaminated clothing and shoes at the site.
In case of contact with material, immediately flush skin or eyes with
running water for at least 15 minutes. Speed in removing material from
skin is of extreme importance. Keep victim quiet and maintain normal body
temperature. Effects may be delayed; keep victim under observation (DOT
1984, Guide 55).
SECTION VI -- USE INFORMATION
Used to make acrylic high polymer with properties closely resembling those
of polymethylmethacrylate (*Lefaux 1968). Monomer for specialty polymers
(e.g., aircraft glazing) (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Poisonous Liquid, n.o.s.) Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site. Stop leak if you can do so without
risk. Use water spray to reduce vapors. Small spills: take up with sand
or other noncombustible absorbent material and place into containers for
later disposal. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 55).
-------
CAS Registry Number: 81-81-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- WARFARIN
CAS Registry Number: 81-81-2
Synonyms: Coumarin,3-(alpha-Acetonylbenzyl)-4-Hydroxy-; l-(4*-hydroxy-
31-coumarinyl)-l-phenyl-3-butanone; 2H-l-benzopyran-2-one, 4-hydroxy-3-
(3-oxo-l-phenylbutyl); 3-(l?-phenyl-21- acetylethyl)-4-hydroxycoumarin;
3-(alpha-acetonylbenzyl)-4-hydroxycoumarin; 200 Coumarin; Athrombine-K;
Brumolin; Compound 42; Coumadin; Coumafen; Coumafene; Coumarin, 3-(alpha-
acetonylbenzyl)-4-hydroxy; Coumarin, 4-hydroxy-3(l-phenyl-3-oxo-butyl)-;
Coumefene; D-Con; Dethmor; Dethnel; Eastern States Duocide; Fasco Fascrat
Powder; Frass-Ratron; Kumader; Kumadu; Kypfarin; Maag Rattentod Cum; Mar-Frin;
Maveran; Prothromadin; Rat-a-way; Rat-b-gon; Rat-Gard; Rat-Kill; Rat-Mix;
Rat-ola; Ratron; Rats-No-More; Rodafarin; Temus W; Warf 42; Warf Compound 42;
Warf-12; Warfarat; Warficide; Zoocoumarin; Co-Rax; Cov-R-Tox; Liqua-Tox;
Martin's Mar-Frin; Mouse- Pak; Rat and Mice Bait; Rat-o-cide #2; Rat-trol;
Ratorex; Ratox; Ratoxin; Ratron G; Rax; Ro-deth; Rodex, Rodex Blox; Rosex;
Rough and Ready Mouse Mix; Solfarin; Spray-trol Brand Roden-trol; Tox-Hid;
Twin light rat away; Vampirinip II & III; Waran; Warfarin plus; Warfarin Q;
3-(alpha-Phenyl-beta- Acetylethyl)-4-Hydroxycoumarin; S-(Acetonylbenzyl)-
4-Hydroxycoumarin; 4-Hydroxy-3(3-oxo-l-Phenylbutyl)-2H-l-Benzopyran-2-one
Chemical Formula: Cir.H,,0,
19 16 4
Molecular Weight: 308.32
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 0.1 mg/m3 (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.1 mg/m3; STEL 0.3 mg/ra3 (*ACGIH 1980)
IDLH: 200 mg/m3 (*NIOSH/OSHA 1981)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
-------
CAS Registry Number: 81-81-2
Page 2 of 4
WARFARIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Pressure (mmHg): Not Found
Melting Point: 322°F, 161°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Weast 1979)
Appearance and Odor: Odorless and colorless solid ("Sax 1984).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Poison B Solid) Extinguish
fire using agent suitable for type of surrounding fire. Use alcohol foam,
carbon dioxide, or dry chemical (Student 1981, p. 416).
Special Fire Fighting Procedures: (Non-Specific -- Poison B Solid)
Wear full protective clothing and self-contained breathing apparatus
(Student 1981, p. 416).
Unusual Fire and Explosion Hazards: Contact with strong oxidizers may
cause fires and explosions (*NIOSH/OSHA 1981).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Strong oxidizers (*NIOSH/OSHA
1981)
-------
CAS Registry Number: 81-81-2
Page 3 of 4
WARFARIN
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: Toxic gases and vapors (e.g.,
carbon monoxide) may be released in heating to decomposition (*NIOSH/OSHA
1981).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Yes (-Arena 1974)
Ingestion: Yes (*Morgan 1982)
Health Hazards (Acute, Delayed, and Chronic): It is classified as very
toxic. Probable oral lethal dose in humans is 50-500 mg/kg, between 1
teaspoon and 1 ounce for a 150 Ib. person (*Gosselin 1976). Material is
an anticoagulant. Toxic effects other than hemorrhage are rarely seen in
humans ("Goodman 1975). Material is believed to be teratogenic in humans
(*Hayes 1982).
Signs and Symptoms of Exposure: Symptoms begin a few days or weeks
after ingestion. They include nose bleed, bleeding gums, pallor, and
sometimes hematomas around joints and on buttocks, blood in urine and
feces. Later, paralysis due to cerebral hemorrhage, and finally
hemorrhagic shock and death may occur (*Doull 1980).
Medical Conditions Generally Aggravated by Exposure: Persons with a
history of blood disorders with bleeding tendencies would be expected to
be at increased risk from exposure (*NIOSH/OSHA 1981).
Emergency and First Aid Procedures: (Non-Specific -- Coumarin
Derivative Pesticide, Solid, n.o.s.) Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 81-81-2
Page 4 of 4
WARFARIN
SECTION VI -- USE INFORMATION
Material is used as a rodenticide for Norway rats and for house mice
(*SRI).
SECTION VII — PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material (see Section V above). Protective clothing
and self-contained breathing apparatus is to be worn in the event of a
spill (*Sittig 1981). Eating and smoking should not be permitted in areas
where it is handled, processed or stored. For small spills: sweep onto
paper or other suitable material. Place in an appropriate container and
burn in a safe place. Large quantities may be destroyed by dissolving in
a flammable solvent (e.g., alcohol) and atomizing in a combustion chamber
(*NIOSH/OSHA 1981).
-------
CAS Registry Number: 82-66-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- DIPHACINONE
CAS Registry Number: 82-66-6
Synonyms: 1,3-Indandione, 2-Diphenylacetyl-; 2-(Diphenylacetyl)-lH-Indene-
l,3(2H)-Dione; 2-(Diphenylacetyl)Indan-l,3-Dione; 2-Diphenylacetyl-l,3-
Diketohydrindene; 2-Diphenylacetyl-l,3-Indanedione; Diandin; Didandin; Didion;
Difacione; Dipaxin; Diphacin; Diphenacin; Diphenandione; Oragulant; PID;
Promar; Ramik; Ratindan 1; Solvan; U1363; lH-Indene-l,3(2H)-Dione,
2-(Diphenylacetyl)-
Chemical Formula: C_,H,,0,
zj ID j
Molecular Weight: 340.38
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: ^D,... oral (mammal)
0.91 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 295-297°F, 146-147°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (*Merck 1976); 17 mg/liter
(Farm Chemicals Handbook 1984, p. C-82)
-------
CAS Registry Number: 82-66-6
Page 2 of 3
DIPHACINONE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Pale yellow crystals (*Merck 1976); odorless
(*0sol 1975)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: The material is similar to couraarin and
indandione (^Morgan 1982). (Non-Specific -- Coumarin Derivative
Pesticide, Solid, n.o.s.) Small fires: dry chemical, carbon dioxide,
water spray, or foam. Large fires: water spray, fog, or foam. Move
container from fire area if you can do it without risk. Fight fire from
maximum distance. Dike fire control water for later disposal; do not
scatter the material (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Coumarin Derivative
Pesticide, Solid, n.o.s.) Keep unnecessary people away; isolate hazard
area and deny entry. Stay upwind; keep out of low areas. Ventilate
closed spaces before entering them. Wear positive pressure breathing
apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition it
emits acrid smoke and fumes (Sax 1984, p. 1231).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (^Worthing 1979)
Conditions to Avoid: Sensitive to light (^Worthing 1979)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits acrid smoke and fumes (Sax 1984, p. 1231).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 82-66-6
Page 3 of 3
DIPHACINONE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 1231)
Health Hazards (Acute, Delayed, and Chronic): This material is
extremely toxic; probable oral lethal dose in humans is 5-50 mg/kg, or
between 7 drops and 1 teaspoonful for a 150-lb. person ("Gosselin 1976).
Signs and Symptoms of Exposure: Can cause death due to inhibiting
blood clotting. Symptoms seen after a few days or a few weeks of repeated
ingestion. Symptoms include nose bleeds, gum bleeding, small measles-like
rash, large bruises especially of the elbows, knees, and buttocks, blood
in urine, blood in stools, shock, and death (Gosselin 1984, p. III-396).
Medical Conditions Generally Aggravated by Exposure: Many medical
conditions will be aggravated by this material (^Goodman 1980).
Emergency and First Aid Procedures: (Non-Specific -- Coumarin
Derivative Pesticide, Solid, n.o.s.) Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Rodenticide (*Worthing 1979); and anticoagulant medication (*Merck 1976).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Do not
touch spilled material; stop leak if you can do it without risk. Use
water spray to reduce vapors. Wear positive pressure breathing apparatus
and special protective clothing. Small spills: take up with sand or
other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 84-74-2
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DIBUTYL PHTHALATE
CAS Registry Number 84-74-2
Synonyms: 1,2-Benzenedicarboxylic Acid Dibutyl Ester; 1,2-Benzenedicar-
boxylic Aeid, Dibutyl Ester; Benzene-o-Dicarboxylic Acid Di-n-Butyl Ester;
Butylphthalate; Celluflex DPB; DPB; Di-n-Butylphthalate; Dibutyl 1,2-Benzene
dicarboxylate; Dibutyl-o-Phthalate; Elaol; Ergoplast FOB; Genoplast B;
Hexaplast M/B; N-Butylphthalate; o-Benzenedicarboxylic Acid, Dibutyl Ester;
Palatinol C; Phthalic Acid Dibutyl Ester; Phthalic Acid, Dibutyl Ester;
Polycizer DBP; PX 104; RC Plasticizer DBF
Chemical Formula: C.-H.-O.
ID // 4
Molecular Weight: 278.34
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: 5 mg/m3 (NIOSH/OSHA 1978, p. 80)
ACGIH TLV: TWA 5 mg/m3; STEL 10 mg/m3 (ACGIH 1983, p. 17)
IDLH: 9300 mg/m3 (NIOSH/OSHA 1978, p. 80)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 644°F, 340°C (*Kirk-Othmer 1978)
<2
Specific Gravity (H00=l): 1.0484 at 20°C/20°C (Hawley 1981, p. 330)
Vapor Pressure (mmHg): 1.1 at 150°C (Hawley 1981, p. 330)
Melting Point: -31°F, -35°C (Sax 1984, p. 926)
Vapor Density (AIR=1): 9.58 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 84-74-2
Page 2 of 3
DIBUTYL PHTHALATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: 13 mg/liter at 25°C (*USEPA/ECAO, 1980)
Appearance and Odor: Colorless, oily liquid with a week aromatic odor
(NIOSH/OSHA 1978, p. 80)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 315°F, 157°C (CC) (NFPA 1984, p. 33);
339.8°F, 171.1°C (OC) (*ITI 1982)
Flammable Limits:
LEL: 0.5% at 456°F (235°C) (NFPA 1984, p. 33)
UEL: Not Found
Extinguishing Methods: Extinguish with dry chemicals or carbon dioxide
(*CHRIS 1978).
Special Fire Fighting Procedures: Firefighters should wear self-
contained breathing apparatus (*NFPA 1978).
Unusual Fire and Explosion Hazards: Reacts explosively with chlorine
(*NFPA 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Liquid chlorine reacts explosively with
dibutyl phthalate (*NFPA 1978).
Incompatibility (Materials to Avoid): Nitrates, strong oxidizers,
strong alkalies, strong acids (NIOSH/OSHA 1978, p. 80); chlorine (Sax
1984, p. 926)
Hazardous Decomposition or Byproducts: None (*NFPA 1978)
Hazardous Polymerization: May Occur:
May Not Occur: Yes (^General Electric
Co. 1980, MSDS #429)
Conditions to Avoid: Not Found
-------
CAS Registry Number: 84-74-2
Page 3 of 3
DIBUTYL PHTHALATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*ACGIH 1980)
Skin: Yes (*Grant 1974)
Ingestion: Yes (*ACGIH 1980)
Health Hazards (Acute, Delayed, and Chronic): Generally non-irritating
to humans ("Martin 1974).
Signs and Symptoms of Exposure: Eye irritation with profuse tearing.
Contact with surface of eye has caused severe stinging pain with profuse
tearing ('"Grant 1974). Mild throat irritation has been observed (*Lefaux
1968). Ingestion has caused nausea, dizziness, photophobia, lachrymation,
and conjunctivitis (-ACGIH 1980).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: If ingested, induce vomiting with
administration of syrup of ipecac (if victim is conscious). If
unconscious, administer artificial respiration. Wash skin with soap and
water. Irrigate eyes with plain tap water. Seek immediate medical
attention (*Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
Plasticizer in nitrocellulose lacquers, elastomers, explosives, nail
polish, and solid rocket propellants; solvent for perfume oils; perfume
fixative; textile lubricating agent; safety glass; insecticides; printing
inks; resin solvent; paper coatings; adhesives; insect repellants for
textiles (Hawley 1981, p. 330). Not registered as a pesticide in the U.S.
(USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Workers should wear rubber or neoprene gloves. In addition, an apron and
face shield should be worn to prevent exposure to eyes. Respiratory
equipment should be worn if vapors are present. Contact lenses should not
be worn (^General Electric Co. 1980, MSDS #429).
-------
CAS Registry Number: 84-80-0
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PHYLLOQUINONE
CAS Registry Number: 84-80-0
Synonyms: Vitamin Kl; 1,4-Naphthalenedione, 2-Methyl-3-(3,7,ll,15-
Tetramethyl-2-Hexadecenyl)-, (R-(R*,R*-(E)))-; 2',3*-Trans-Vitamin Kl;
2-Methyl-3-(3,7,11,15-Tetramethyl-2-Hexadecenyl)-1,4-Naphthalenedione;
2-Methyl-3-Phytyl-l,4-Naphthoquinone; 3-Phytylmenadione; Alpha-Phylloquinone;
Antihemorrhagic Vitamin; Aquamephyton; Phytomenadione; Phytonadione;
Phytylmenadione; Synthex P; Trans-Phylloquinone; Vitamin Kl (20); Combinal Kl;
K-Ject; Kativ N; Kephton; Kinadion; Konakion; Mephyton; Mono-Kay; Monodion
Chemical Formula: C01H.,00
jl 4o 2
Molecular Weight: 450.68
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (mouse)
25 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 284-293°F, 140-145°C at 0.001 mmHg (*Weast 1979)
Specific Gravity (H20=l): 0.967 at 25°C/25°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: -4°F, -20°C (-Weast 1979)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Merck 1976)
-------
CAS Registry Number: 84-80-0
Page 2 of 3
PHYLLOQUINONE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Phylloquinone is a yellow viscous oil ("Merck
1976) or solid (*0sol 1975). It is odorless (*Hawley 1977).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Medicines, n.o.s.) Extinguish
with dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984,
Guide 11).
Special Fire Fighting Procedures: (Non-Specific -- Medicines, n.o.s.)
Move container from fire area if you can do so without risk. Spray
cooling water on containers that are exposed to flames until well after
fire is out (DOT 1984, Guide 11).
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Merck 1976)
Conditions to Avoid: Sunlight (*Merck 1976)
Incompatibility (Materials to Avoid): Phylloquinone decomposes in
sunlight and is destroyed by alkali hydroxides and reducing agents (*Merck
1976).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits acrid smoke and fumes (Sax 1985, p. 1933).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 84-80-0
Page 3 of 3
PHYLLOQUINONE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1985, p. 1933) -.
Health Hazards (Acute, Delayed, and Chronic): High oral toxicity (Sax
1985, p. 1933). Intravenous injection can cause toxic responses and
occasionally death (*AMA 1977).
Signs and Symptoms of Exposure: Rapid intravenous administration of
phylloquinone has produced flushing, irregular breathing, and chest pains
(^Goodman 1975). In newborns, can cause hemolytic anemia and
hemoglobinuria (*AMA 1977).
Medical Conditions Generally Aggravated by Exposure: In patients who
have severe liver disease, administration of large doses of menadione or
phylloquinone may further depress function of liver ,(*Goodman 1975).
Individuals resistant to coumarin may have unusual sensitivity to the
antidotal effects of Vitamin K (-Ladu 1971).
Emergency and First Aid Procedures: (Non-Specific -- Medicines,
n.o.s.) Move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult,, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Remove and isolate . .
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature (DOT 1984, Guide 11).
SECTION VI -- USE INFORMATION
Phylloquinone is a dietary principle essential for normal biosynthesis of
several factors required for clotting of blood and as a therapeutic drug
to correct bleeding tendency (*Goodman 1975). It is also used as a food
supplement (-Hawley 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Medicines, n.o.s.) Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas. Wear
self-contained (positive pressure if available) breathing apparatus and
full protective clothing. Shut off ignition sources; no flares, smoking
or flames in hazard area. Keep combustibles (wood, paper, oil, etc.) away
from spilled material. Do not touch spilled material. Small spills:
absorb with sand or other noncombustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 11). . ;
-------
CAS Registry Number: 86-50-0
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- AZINOPHOS-METHYL
CAS Registry Number: 86-50-0
Synonyms: Methyl Guthion; l,2,3-Benzotriazin-4(3H)-one, 3-(Mercapto-
methyl)-, 0,0-Dimethyl Phosphorodithioate; 3-(Mercaptomethyl)-1,2,3-
Benzotriazin-4(3H)-one 0,0- Dimethyl Phosphorodithioate S-Ester; Bay 17147;
Bay 9027; Bayer 17147; Bayer 9027; Benzotriazine Derivative of a Methyl
Dithiophbsphate; Benzotriazinedithiophosphoric Acid Dimethoxy Ester; Carfene;
Cotneon; Cotnion; Cotnion Methyl; Crysthion 2L; Crysthyon; DBD;
Dimethyldithiophosphoric Acid N-Methylbenzazimide Ester; ENT 23,233; Gothnion;
Gusathion; Gusathion 25; Gusathion K; Gusathion M; Gusathion Methyl;
Gusathion-20; Guthion; Methyl Azinphos; Methyl Gusathion; Metiltriazotion;
N-Methylbenzazimide, Dimethyldithiophosphoric Acid Ester; NCI-C00066;
0,0-Dimethyl S-(3,4-Dihydro-4-Keto-l,2,3-Benzotriazinyl-3-Methyl)
Dithiophosphate; 0,0-Dimethyl S-(4-Oxo-l,2,3-Benzotriazino(3)-Methyl)
Thiothiohophosphate; 0,0-Dimethyl S-(4-Oxo-3H-l,2,3-Benzotriazine-3-Methyl)
Phosphorodithioate; 0,0-Dimethyl S-(4-Oxobenzotriazino-3-Methyl)
Phosphorodithioate; 0,0-Dimethy1 S-4-Oxo-1,2,3-Benzotriazin-3(4H)-yImethyl
Phosphorodithioate; 0,0-Dimethy1-S-(1,2,3-Benzotriazinyl-4-Keto)Methyl
Phosphorodithioate; 0,0-Dimethy1-S-(Benzaziminomethy1) Dithiophosphate;
Phosphorbdithioic Acid, 0,0-Dimethyl Ester, S-Ester With 3-(Mercaptomethyl)-
l,2,3-Benzotriazin-4(3H)-one; Phosphorodithioic Acid, 0,0-Dimethyl S-((4-Oxo-
l,2,3-Benzotriazin-3(4H)-yl)Methyl) Ester; Phosphorodithioic Acid, 0,0-
Dimethyl S-(4-Oxo-l,2,3-Benzotriazin-3(4H)-ylmethyl)Ester; R 1582;
S-(3,4-Dihydro-4-Oxo-1,2,3-Benzotriazin-3-yImethyl) 0,0-Dimethyl
Phosphorodithioate; S-(3,4-Dihydro-4-Oxo-Benzo(alpha)-(l,2,3-Triazin-3-yl
Methyl) 0,0-Dimethyl Phosphorodithioate
Chemical Formula: C H N.O PS
Molecular Weight: 317.34
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 200 ug/m3 (skin) (--NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.2 mg/m3; STEL 0.6 mg/m3 (*ACGIH 1980a)
IDLH: Not Found
Other Limits Recommended: ADI 0.0025 mg/kg (*NRC 1977). Toxicity
information: LC inhalation (rat) 0.069 mg/liter/1 hour ("NIOSH/RTECS
1985).
-------
CAS Registry Number: 86-50-0
Page 2 of 4
AZINOPHOS-METHYL
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): 1.44 at 20°C/4°C (-Merck 1983)
Vapor Pressure (mmHg): Negligible at 20°C (-'-Worthing 1979)
Melting Point: 163-165°F; 73-74°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 33 ppm at room temperature ("Worthing 1979)
Appearance and Odor: White crystals ('^Worthing 1979) or brown waxy
solid ('-Hawley 1981)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray, or foam. Large fires: water spray, fog, or foam ("DOT 1984),
Special Fire Fighting Procedures: Move containers from fire area if
you can do it without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material ("DOT 1984).
Unusual Fire and Explosion Hazards: Some of the formulations may burn,
but none of them ignite easily. Container may explode in the heat of the
fire (''-DOT 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: . Unstable at temperatures above 390°F (200°C)
(^•Worthing 1979)
Stable:
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Rapidly hydrolyzed by cold
alkali or cold acid (-Worthing 1979)
-------
CAS Registry Number: 86-50-0
Page 3 of 4
AZINOPHOS-METHYL
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Hayes 1982, p. 358)
Skin: Yes (Hayes 1982, p. 358)
Ingestion: Yes (Hayes 1982, p. 358)
Health Hazards (Acute, Delayed, and Chronic): Acute: extremely
toxic. Probable oral lethal dose in humans is 5-50 mg/kg, or between 7
drops and 1 teaspoon for a 70 kg (150 Ib.) person. A potent
cholinesterase inhibitor which can cause death ("Gosselin 1976).
Signs and Symptoms of Exposure: Symptoms of nausea, vomiting,
diarrhea, excessive salivation, blurring of vision and other signs of
cholinesterase inhibition, loss of muscle coordination, twitching of
muscles, confusion, difficulty breathing, convulsions, and death are
observed with this organophosphate poison (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (*DOT 1984).
SECTION VI -- USE INFORMATION
Insecticide for control of pests on a wide range of crops. Used to
control boll weevil on cotton, and for control of insects on deciduous
fruits, nuts, vegetables, field crops, citrus, and for non-agricultural
use (*SRI).
-------
CAS Registry Number: 86-50-0
Page 4 of 4
AZINOPHOS-METHYL
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Wear positive pressure breathing apparatus and special protective
clothing. Remove and isolate contaminated clothing at the site (*DOT
1984). Do not touch spilled material. Stop leak if you can do so without
risk. Use water spray to reduce vapors. Small spills: absorb with sand
or other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal ("DOT 1984).
-------
CAS Registry Number: 86-88-4
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- ANTU
CAS Registry Number: 86-88-4
Synonyms: Urea, l-(l-Naphthyl)-2-Thio-; alpha-Naphthylthiourea;
l-(l-Naphthyl)-2-Thiourea; l-(l-Naphthyl)Thiourea; 1-Naphthyl Thiourea;
1-Naphthylthiourea; alpha-Naphthothiourea; alpha-Naphthylthiocarbamide;
alphanaphthyl Thiourea; Alrato; Anturat; Bantu; Chemical 109; Dirax; Kill
Kantz; Kripid; Krysid; Krysid PI; N-(1-Naphthyl)-2-Thiourea;
N-1-Naphthylthiourea; Naphtox; Rat-Tu; Rattrack; Smeesana; Thiourea,
1-Naphthalenyl-; U-5227; USAF EK-P-5976
Chemical Formula: C11H10N2S
Molecular Weight: 202.23
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 0.3 mg/m3 (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.3 mg/m3; STEL 0.9 mg/m3 (skin) (*ACGIH 1980)
IDLH: 100 mg/m3 (*NIH EPA, OHM/TADS 1984)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): 0 at 25°C (*Sax 1975)
Melting Point: 388°F, 198°C (*Merck 1976)
Vapor Density (AIR=1): 6.99 (*NIH EPA, OHM/TADS 1984)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.6 g/L water at 25°C (*Merck 1976)
-------
CAS Registry Number: 86-88-4
Page 2 of 3
ANTU
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: White crystal or powder; technical product is
gray powder (*Clarke 1981). No odor (*ACGIH 1980); bitter taste (*Merck
1976).
SECTION III--- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): May burn but will not ignite readily (-DOT
1984)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog, or foam (-DOT 1984).
Special Fire Fighting Procedures: Stay upwind, and out of low areas.
Wear self-contained breathing apparatus and full protective clothing (*DOT
1984).
Unusual Fire and Explosion Hazards: Emits toxic fumes upon
decomposition (*Sax 1975).
SECTION IV — REACTIVITY DATA
Stability: Unstable:
Stable: Yes (''"Worthing 1979)
Conditions to Avoid: Decomposing heat ("Sax 1975)
Incompatibility (Materials to Avoid): It reacts with silver nitrate
and strong oxidizers (-Sax 1975)
Hazardous Decomposition or Byproducts: When heated it emits sulfur
dioxide, oxides of nitrogen, and carbon monoxide (*NIOSH/OSHA 1981).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 86-88-4
Page 3 of 3
ANTU
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Moderately toxic:
probable oral lethal dose (human) 0.5-5 gm/kg, or between 1 ounce and 1
pint (or .1 Ib.) for 150 Ib. person (*Gosselin 1976). Chronic sublethal
exposure may cause antithyroid activity. Can produce hyperglycemia of
three times normal in three hours ('vRumack 1975 to Present) .
Signs and Symptoms of Exposure: Symptoms include seizures, pulmonary
edema and dermal irritation ("Rumack 1975 to Present). Ingestion may
cause vomiting, shortness of breath, and bluish discoloration of the skin
(*NIOSH/OSHA 1981).
Medical Conditions Generally Aggravated by Exposure: People with
chronic respiratory disease or liver disease may be especially at risk
(*NIOSH/OSHA 1981).
Emergency and First Aid Procedures: Move victim to fresh air. Treat
pulmonary edema with positive pressure oxygen (*Rumack 1975 to Present).
Immediately flush with fresh water for at least 15 minutes in case of skin
or eye contact (*Gosselin 1976).
SECTION VI -- USE INFORMATION
This material was used primarily as a rodenticide for control of adult
Norway rats. It is not produced commercially in the U.S. (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact; wear proper respiratory protection and
protective clothing (see Section V above). Do not touch spilled material,
stay upwind, keep out of low areas, deny entry, wear protective clothing
(*DOT 1984).
-------
CAS Registry Number: 87-86-5
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PENTACHLOROPHENOL
CAS Registry Number: 87-86-5
Synonyms: 2,3,4,5,6-Pentachlorophenol; Chem-Tol; Chlorophen; Dowicide 7;
Durotox; EP 30; Fungifen; Grundier Arbezol; Lauxtol; Lauxtol A; Liroprem;
NCI-C54933; PCP; Penchlorol; Penta; Penta-Kil; Pentachlorophenate; Pentacon;
Pentasol; Penwar; Peratox; Permacide; Permagard; Permasan; Permatox DP-2;
Permite; Santophen; Santophen 20; Sinituho; Term-I-Trol; Thompson's Wood Fix;
Weedone; Phenol, Pentachloro-
Chemical Formula: C.HCl.O
o :>
Molecular Weight: 266.35
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 500 yg/m3 (NIOSH/OSHA 1978, p. 148)
ACGIH TLV: TWA 0.5 mg/m3; STEL 1.5 mg/m3 (skin) (*ACGIH 1982)
IDLH: 150 mg/m3 (NIOSH/OSHA 1978, p. 148)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 588°F, 309°C (*Merck 1976)
Specific Gravity (H20=l): 1.978 at 22°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 0.0002 at 20°C (NIOSH/OSHA 1978, p. 148)
Melting Point: 374°F, 190°C (*Merck 1976)
Vapor Density (AIR=1): 9.20 (*Verschueren 1983)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.002 g/100 ml at 30°C (*Spencer 1982)
-------
CAS Registry Number: 87-86-5
Page 2 of 4
PENTACHLOROPHENOL
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Needle-like crystals (*Merck 1983). Colorless
crystals (pure); dark greyish powder or flakes (crude product) (*Spencer
1982). Phenolic odor ("Spencer 1982) and also a very pungent odor when
hot (-Merck 1976).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: This material may burn but may not ignite readily
(*DOT 1984). Under normal conditions it is not flammable (-CHRIS 1978).
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Water spray may be used to extinguish fire.
Dry chemicals, foam, or carbon dioxide can also be used. Use water to
keep fire-exposed containers cool (*NFPA 1978).
Special Fire Fighting Procedures: Full protective clothing:
self-contained breathing apparatus, rubber gloves, boots, and bands around
legs, arms, and waist. No skin surface should be exposed (*NFPA 1978).
If protective clothing becomes soaked it must be replaced immediately
(*Clayton and Clayton 1982).
Unusual Fire and Explosion Hazards: Liquid must be moderately heated
before ignition will occur (*NFPA 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Prolonged heating above 200°C produces trace
amounts of octachlorodibenzo-para-dioxin (*IARC 1972-1985).
Incompatibility (Materials to Avoid): Contact with strong oxidizers
may cause fires or explosions (*NIOSH/OSHA 1981).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes of chlorides (*Sax 1975). Hydrogen chloride,
chlorinated phenols, and carbon monoxide may be released upon
decomposition (*NIOSH/OSHA 1981).
-------
CAS Registry Number: 87-86-5
Page 3 of 4
PENTACHLOROPHENOL
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Clayton and Clayton 1982)
Skin: Yes (-Clayton and Clayton 1982)
Ingestion: Yes (*Clayton and Clayton 1982)
Health Hazards (Acute, Delayed, and Chronic): Poisonous if swallowed
or inhaled (-DOT 1984). Very toxic: probable oral lethal dose (human)
50-500 mg/kg (1 teaspoon to 1 ounce) for 70 kg person (150 Ibs.)
(*Gosselin 1976). Lethal oral doses in humans have been reported at 29
mg/kg (*NIOSH 1985). Causes lung, liver, and kidney damage, and contact
dermatitis (*Merck 1976). Inhalation results in acute poisoning centering
in circulatory system with accompanying heart failure. Also, visual
damage, scotoma, inflammation of conjuctiva, cornea opacity, cornea
numbness and slight pupil dilation are experienced (*ACGIH 1980).
Repeated exposure to commercial material preceded aplastic anemia, pure
red cell aplasia, Hodgkins disease and acute leukemia ('^Roberts 1983).
Signs and Symptoms of Exposure: Ingestion causes increased then
decreased respiration, blood pressure, and urinary output; fever;
increased bowel action; motor weakness; collapse with convulsions; and
death (*Merck 1976). Inhalation of dust and mist cause violent sneezing
and coughing (*USEPA, AWQC 1980). Liquid or solid dermal contact causes
smarting of skin and first-degree burns on short exposure; may cause
secondary burns on long exposure (*CHRIS 1978).
Medical Conditions Generally Aggravated by Exposure: Kidney and liver
diseases (*Clayton and Clayton 1982).
Emergency and First Aid Procedures: Move victim to fresh air. Remove
and isolate contaminated clothing and shoes at the site. In case of
contact with material, immediately flush skin or eyes with running water
for at least 15 minutes (*DOT 1984). Bathe and shampoo contaminated skin
and hair promptly with soap and water. Flush eyes with copious amount of
clean water. Systemic poisoning: reduce elevated body temperature by
physical means. (Do not administer aspirin.) Administer sponge baths and
cover with low-temperature blankets (^Morgan 1982).
-------
CAS Registry Number: 87-86-5
Page 4 of 4
PENTACHLOROPHENOL
SECTION VI -- USE INFORMATION
Wood preservative; soil fumigant for termites, herbicide, fungicide,
slimicide, algicide, antibacterial agent in disinfectants and cleaners
(*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation. Wear proper respiratory protection and protective
clothing (see Section V above). Avoid contact with solid and dust. Keep
unnecessary people away ("CHRIS 1978). Ventilate area of spill. Collect
spilled material in most convenient and safe manner and deposit in sealed
containers for reclamation or disposal in secure sanitary landfill.
Liquid should be absorbed in vermiculite, dry sand, earth, or similar
material (*NIOSH/OSHA 1981).
-------
CAS Registry Number: 88-05-1
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ANILINE, 2,4,6-TRIMETHYL-
CAS Registry Number: 88-05-1
Synonyms: 2,4,6-Trimethylaniline; 2-Aminomesitylene; Aminomesitylene;
Benzenamine, 2,4,6-Trimethyl-; Mesidin; Mesidine; Mesitylamine; Mesitylene,
2-Amino-
Chemical Formula: C9Hi3N
Molecular Weight: 135.2
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found ^
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(mouse) 0.29 mg/liter/2 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 450-451°F, 232-233°C (Weast 1980, p. C-148)
Specific Gravity (H 0=1): 0.9633 (Weast 1980, p. C-148)
Vapor Pressure (mmHg): Not Found
Melting Point: 23°F, -5°C (Weast 1980, p. C-148)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Not Found
-------
CAS Registry Number: 88-05-1
Page 2 of 3
ANILINE, 2,4,6-TRIMETHYL-
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Poisonous Liquid, n.o.s.)
Small fires: dry chemical, carbon dioxide, water spray or foam. Large
fires: water spray, fog or foam. Move container from fire area if you
can do so without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (DOT 1984 j
Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Poisonous Liquid,
n.o.s.) Keep unnecessary people away; isolate hazard area and deny
entry. Stay upwind; keep out of low areas. Ventilate closed spaces
before entering them. Wear positive pressure breathing apparatus and
special protective clothing. If water pollution occurs, notify
appropriate authorities (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of nitrogen oxides (Sax 1984, p. 2661).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Decomposing heat (Sax 1984, p. 2661)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of nitrogen oxides (Sax 1984, p. 2661).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 2661)
-------
CAS Registry Number: 88-05-1
Page 3 of 3
ANILINE, 2,4,6-TRIMETHYL-
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): This material is
moderately toxic orally. It is also considered highly toxic by
unspecified routes. It is a skin and eye irritant (Sax 1984, p. 2661).
Suspect occupational carcinogen (Clayton and Clayton 1981-82, p. 2892).
(Non-Specific -- Aromatic Amines) The danger of acute poisoning is
represented by methemoglobinemia leading to adverse effects on the red
cells. A number of the amines may act as skin sensitizers (Encyc Occupat
Health and Safety 1983, p. 142).
Signs and Symptoms of Exposure: Repeated exposure results in narrowing
of peripheral vision, increase in size of blind spot and decrease in
photosensitivity ("Grant 1974).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Poisonous Liquid,
n.o.s.) Move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Speed in removing material
from skin is of extreme importance. Remove and isolate contaminated
clothing and shoes at the site. Keep victim quiet and maintain normal
body temperature. Effects may be delayed, keep victim under observation
(DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Not Found
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Poisonous Liquid, n.o.s.) Do not touch spilled material;
stop leak if you can do so without risk. Use water spray to reduce
vapors. Small spills: absorb with sand or other noncombustible absorbent
material and place into containers for later disposal. Large spills:
dike far ahead of spill for later disposal. Wear positive pressure
breathing apparatus and special protective clothing (DOT 1984, Guide 55).
-------
CAS Registry Number: 88-85-7
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DINOSEB
CAS Registry Number: 88-85-7
Synonyms: 2,4-Dinitro-6-(l-Methylpropyl)Phenol; 2,4-Dinitro-6-sec-
Butylphenof; 2-(l-Methylpropyl)-4,6-Dinitrophenol; Phenol, 2-sec-Butyl-4,6-
Dinitro-; 4,6-Dinitro-2-(l-Methyl-n-Propyl)Phenol; 4,6-Dinitro-2-
sec-Butylphenol; 4,6-Dinitro-o-sec-Butylphenol; AATOX; Aretit; Basanite; BNP
20; BNP 30; Butaphene; Caldon; Chemox General; Chemox PE; DBNF; Dibutox;
Dinitrall; Dinitro Weed Killer; Dinitro-Ortho-Sec-Butyl Phenol;
Dinitrobutylphenol; Phenol, 2-(l-Methylpropyl)-4,6-Dinitro-; DN 289; DNBP;
DNOSBP; DNSBP; Dow General; Dow General Weed Killer; Dow Selective Weed
Killer; Dytop; Elgetol; Elgetol 318; ENT 1,122; Gebutox; Hivertox; Kiloseb;
Knoxweed; Ladob; Laseb; Nitropone; Phenol, 2-(l-Methylpropyl)-4,6-Dinitro-;
Phenol, 2-sec-Butyl-4,6-Dinitro-; Premerg; Sinox General; Subitex
Chemical Formula: C10H12N2°5
Molecular Weight: 240.2
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC, inhalation
(rat) 0.045 rag/liter/3 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): 1.2647 at 45°C (*Weed Science Society of
America 1979)
Vapor Pressure (mmHg): 1 at 151.1°C (*Weed Science Society of America
1979)
Melting Point: 100-108°F, 38-42°C (Merck 1983, p. 479)
-------
CAS Registry Number: 88-85-7
Page 2 of 4
DINOSEB
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Density (AIR=1): 7.73 (Sax 1984, p. 582)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.0052 g/100 ml (-Weed Science Society of America
1979)
Appearance and Odor: Orange-brown viscous liquid (Merck 1983, p. 479);
pungent odor ("Weed Science Society of America 1979) or crystals (*Sax
1979); orange solid when pure; technical grade is orange-brown solid
(Worthing 1983)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 60.1°F to 84.9°F, 15.6°C to 29.4°C for 3
commercial products ("Weed Science Society of America 1979)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This material is a dinitrophenol herbicide
(Buchel 1983, p. 304). (Non-Specific -- Dinitrophenol, Flammable Solid)
Extinguish by flooding with water. Cool all affected containers with
flooding quantities of water. Apply water from as far a distance as
possible (Student 1981, p. 205).
Special Fire Fighting Procedures: This is a dinitrophenol herbicide
(Buchel 1983, p. 304). (Non-Specific -- Dinitrophenol, Flammable Solid)
Wear self-contained breathing apparatus and full protective clothing. If
fire becomes uncontrollable, evacuate for a radius of 5000 feet (Student
1981, p. 206).
Unusual Fire and Explosion Hazards: This is a dinitrophenol herbicide
(Buchel 1983, p. 304). (Non-Specific -- Dinitrophenol, Flammable Solid).
It is dangerously explosive. When not water wet it is a high explosive.
Dry, the material is easily ignited and it will burn very rigorously
(Student 1981, p. 205).
-------
CAS Registry Number: 88-85-7
Page 3 of 4
DINOSEB
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-Kearney 1975)
Conditions to Avoid: Appear to be stable in acid solution, but are
susceptible to decomposition by ultraviolet radiation in alkaline
solution ("Kearney 1975).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: On decomposition, nitro
compounds such as this emit toxic fumes ('"Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes ("Weed Science Society of America
1979)
Skin: Yes (Hawley 1981, p. 374)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic:
Probable oral lethal dose is 5-50 mg/kg; between 7 drops and 1 teaspoonful
for 70 kg person (150 Ib.) (Gosselin 1976, p. 11-197).
Signs and Symptoms of Exposure: Marked fatigue, tremendous thirst,
profuse sweating, flushing of face. Nausea, vomiting, abdominal pain,
occasional diarrhea. Restlessness, anxiety, excitement, occasionally
leading to convulsions. Rise in body temperature, rapid heart beat,
difficulty breathing, bluish skin and sometimes muscle cramps. Loss of
consciousness, cessation of breathing and death ("Gosselin 1976). Skin:
staining of skin and minor irritation by very small amount. Eyes: mild
to moderate irritation expected. Inhalation: dusts may be irritating and
may cause serious illness (*Weed Science Society of America 1979).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Wash contaminated skin and hair
promptly with soap and water, or with water alone. Flush chemical from
eyes with copious amount of water. In systemic poisoning: reduce
elevated body temperature by physical means. Administer sponge baths and
cover victim with low-temperature blankets (*Morgan 1982)
-------
CAS Registry Number: 88-85-7
Page 4 of 4
DINOSEB
SECTION VI -- USE INFORMATION
Plant growth regulator; insecticide and herbicide (Hawley 1981, p. 374).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
This is a dinitrophenol herbicide (Buchel 1983, p. 340). (Non-Specific
Dinitrophenol, Flammable Solid) Wear boots, protective gloves and
goggles. Do not handle broken packages without protective equipment.
Wash away any material which may have contacted the body with copious
amounts of water. Keep sparks, flames, and other sources of ignition
away. Keep material out of water sources and sewers. Keep spilled
material wet. Do not attempt to sweep up dry material (Student 1981, p.
206).
-------
CAS Registry Number: 91-08-7
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- TOLUENE 2,6-DIISOCYANATE
CAS Registry Number: 91-08-7
Synonyms: 2,6-Toluene Diisocyanate; l,3-Diisocyanato-2-Methylbenzene;
2,6-Diisocyanato-1-MethyIbenzene; 2,6-Diisocyanatotoluene; 2,6-TDI;
2-Methyl-m-Phenylene Isocyanate; 2-Methyl-meta-Phenylene Isocyanate; Benzene,
2,6-Diisocyanato-l-Methyl-; Hylene TCPA; Hylene TIC; Hylene TM; Hylene TM-65;
Hylene TRF; Isocyanic Acid, 2-Methyl-m-Phenylene Ester; Isocyanic Acid,
2-Methyl-meta-Phenylene Ester; m-Tolylene Diisocyanate; meta-Tolylene
Diisocyanate; NIAX TDI; NIAX TDI-P; Tolylene 2,6-Diisocyanate
Chemical Formula: C.H-N-O.
y o / /
Molecular Weight: 174.2
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(mouse) 0.091 mg/liter 4 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 264-271°F, 129-133°C at 18 mmHg (*IARC 1972-1985)
Specific Gravity (H20=l): 1.22 at 25°C for a 80% 2,4:20% 2,6 TDI
mixture (*ACGIH 1980)
Vapor Pressure (mmHg): 0.5 at 25°C for a 80% 2,4:20% 2,6 TDI mixture
(*ACGIH 1980)
Melting Point: 68-72°F, 20-22°C for a 80% 2,4:20% 2,6 TDI mixture
(*ACGIH 1980)
Vapor Density (AIR=1): Not Found
-------
CAS Registry Number: 91-08-7
Page 2 of 4
TOLUENE 2,6-DUSOCYANATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Not Found
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 270°F, 132°C for a 80% 2,4:20% 2,6 TDI
mixture (*ACGIH 1980)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Should be extinguished with carbon dioxide, dry
chemical or inert gas. For large fires fight with water in the form of
spray (*Encyc Occupat Health and Safety 1981).
Special Fire Fighting Procedures: Should wear a self-contained
breathing apparatus (*Encyc Occupat Health and Safety 1971). Move
container from fire area if you can do so without risk. Spray cooling
water on containers that are exposed to flames until well after fire is
out. Fight fire from maximum distance. Dike fire control water for later
disposal; do not scatter the material (DOT 1984, Guide 57).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of nitrogen oxides (Sax 1984, p. 1084). Ventilation
should be adequate. If polyurethane products are heated, protection
against isocyanate release is necessary (*Encyc Occupat Health and Safety
1971).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Decomposing heat (Sax 1984, p. 1084)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of nitrogen oxides (Sax 1984, p. 1084).
-------
CAS Registry Number: 91-08-7
Page 3 of 4
TOLUENE 2,6-DIISOCYANATE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 1030)
Skin: Yes (Hawley 1981, p. 1030)
Ingestion: Yes (Hawley 1981, p. 1030)
Health Hazards (Acute, Delayed, and Chronic): Classified as slightly
toxic orally. Probable oral lethal dose in humans is 5 to 15 g/kg or
between 1 pint and 1 quart for a 70 (150 Ib.) person ("Gosselin 1976).
Particularly poisonous when breathed. This is among the most poisonous of
isocyanates (*Lefaux 1968). Acute and chronic exposures to low
concentrations may produce asthmatic attacks (Doull 1980, p. 533).
Signs and Symptoms of Exposure: It is a powerful irritant of the eyes,
skin and respiratory tract. Tightness in the chest, coughing, shortness
of breath and labored breathing have been reported upon inhalation of low
concentrations (Gosselin 1984, p. 11-414).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Rescuers must wear self-contained
breathing apparatus. Remove patient rapidly from the contaminated
environment (*Rumack 1975 to Present). Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed, keep victim under observation (DOT 1984, Guide 57).
SECTION VI -- USE INFORMATION
Manufacturing of polyurethane foams, elastomers, and coatings;
crosslinking agent for nylon 6 (*Hawley 1977).
-------
CAS Registry Number: 91-08-7
Page 4 of 4
TOLUENE 2,6-DIISOCYANATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Decontaminate with a suitable solution such as 10 percent ammonia with
alcohol (*Encyc Occupat Health and Safety 1971). Keep unnecessary people
away, isolate hazard area and deny entry. Stay upwind and keep out of low
areas. Ventilate closed spaces before entering them. Wear positive
pressure breathing apparatus and special protective clothing. Shut off
ignition sources; no flares, smoking or flames in hazard area. Do not
touch spilled material, stop leak if you can do so without risk. Use
water spray to reduce vapors. Small spills: absorb with sand or other
noncombustible material and place into containers for later disposal.
Small dry spills: with clean shovel place material into clean dry
container and cover; move containers from spill area. Large spills: dike
far ahead of spill for later disposal (DOT 1984, Guide 57).
-------
CAS Registry Number: 93-05-0
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DIETHYL-p-PHENYLENEDIAMINE
CAS Registry Number: 93-05-0
Synonyms: N,N-Diethyl-p-Phenylenediamine; 1,4-Benzenediamine, N,N-diethyl-;
4-(diethylamino)aniline; 4-Amino-N,N-diethylaniline; Diethyl-para-phenylene-
diamine; Diethylaminoaniline; N,N-Diethyl-4-aminoaniline; N,N-Diethyl-para-
phenylenediamine; p-(Diethylamino)aniline; p-Amino-N,N-diethylaniline;
p-Aminodiethylaniline; p-Phenylenediamine, N,N-diethyl-
Chemical Formula: C-.H-.N,.
1U 16 2.
Molecular Weight: 164.28
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: ID, oral (cat)
300 mg/kg; ID- dermal (rabbit) 5 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 500-504°F, 260-262°C (*Hawley 1977)
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Hawley 1977)
Appearance and Odor: Material is a liquid (*Hawley 1977); odor not
found.
-------
CAS Registry Number: 93-05-0
Page 2 of 3
DIETHYL-p-PHENYLENEDIAMINE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Phenylenediamine) Extinguish
with dry chemical, carbon dioxide, water spray, fog, or foam (DOT 1984,
Guide 53).
Special Fire Fighting Procedures: (Non-Specific -- Phenylenediamine)
Stay upwind; keep out of low areas. Wear self-contained (positive
pressure if available) breathing apparatus and full protective clothing.
Move container from fire area if you can do it without risk (DOT 1984,
Guide 53).
Unusual Fire and Explosion Hazards: Emits toxic nitrogen oxide fumes
when heated to decomposition (Sax 1984, p. 1024).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Material emits toxic nitrogen
oxides fumes when heated to decomposition. (Sax 1984, p. 1024).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Yes (Sax 1984, p. 1024)
Ingestion: Yes (Sax 1984, p. 1024)
Health Hazards (Acute, Delayed, and Chronic): The lowest toxic dermal
dose reported in humans is 73 yg/kg (*NIOSH/RTECS 1985).
-------
CAS Registry Number: 93-05-0
Page 3 of 3
DIETHYL-p-PHENYLENEDIAMINE
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific --
Phenylenediamine) Move victim to fresh air; call emergency medical care.
Remove and isolate contaminated clothing and shoes at the site. In case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes (DOT 1984, Guide 53).
SECTION VI -- USE INFORMATION
Material is used as a dye intermediate and in color photography (*Hawley
1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Phenylenediamine) Do not touch spilled material; stop
leak if you can do it without risk. Small spills: take up with sand or
other noncombustible absorbent material and place into containers for
later disposal. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 53).
-------
CAS Registry Number: 95-48-7
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CRESYLIC ACID
CAS Registry Number: 95-48-7
Synonyms: o-Cresol; l-Hydroxy-2-Methylbenzene; 2-Cresol; 2-Hydroxytoluene;
2-Methylphenol; o-Cresylic Acid; o-Hydroxytoluene; o-Methylphenol;
o-Methylphenylol; o-Oxytoluene; o-Toluol; Orthocresol; Phenol, 2-Methyl-
Chemical Formula: C,H00
/ o
Molecular Weight: 108.15
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 5 ppm (22 mg/m3) (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: Air: TWA 5 ppm (22 mg/m3) (skin) (*ACGIH 1983)
IDLH: 250 ppm (NIOSH/OSHA 1978, p. 72)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 376°F, 191°C (*Weast 1979)
{2
Specific Gravity (H 0=1): 1.047 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): 1 at 38.2°C (-Sax 1979)
Melting Point: 88°F, 31°C (*Weast 1979)
Vapor Density (AIR=1): 3.72 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in 40 parts water (*Merck 1983)
Appearance and Odor: Colorless liquid (NFPA 1978, p. 49-32), colorless
crystalline compound (*Clayton and Clayton 1981-82) or white crystals
(*Hawley 1981) with phenolic odor (*Merck 1983)
-------
CAS Registry Number: 95-48-7
Page 2 of 4
CRESYLIC ACID
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 81-83°C (*Merck 1983)
Flammable Limits:
LEL: 1.4% at 300°F (*Sax 1979)
UEL: Not Found
Extinguishing Methods: Water to blanket the fire and dry chemical,
foam, or carbon dioxide to extinguish the flames (*NFPA 1978). Extinguish
small f-ires with dry chemical, carbon dioxide, water spray, or foam. For
large fires use water spray, fog, or foam. Move container from fire area
if you can do so without risk (»DOT 1984).
Special Fire Fighting Procedures: Use water to keep fire-exposed
containers cool (*NFPA 1978). Fight fire from a maximum distance. Dike
fire control water for later disposal; don't scatter the material. Wear
positive pressure breathing apparatus and full protective clothing. Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Ventilate closed spaces before entering them.
Remove and isolate contaminated clothing at the site (*DOT 1984).
Unusual Fire and Explosion Hazards: Fire may produce irritating or
poisonous gases. Runoff from fire control water may give off poisonous
gases. This material may burn but does not ignite readily. Container may
explode in heat of fire (*DOT 1984). Slight explosion and fire hazard in
the form of vapor when exposed to heat or flame (Sax 1984, p. 814).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Reacts violently with nitric
acid, oleum, and chlorosulfonic acid (Sax 1984, p. 814).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes (*Sax 1979).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 279)
Conditions to Avoid: Not Found
-------
CAS Registry Number: 95-48-7
Page 3 of 4
CRESYLIC ACID
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Rumack 1975 to Present)
Skin: Yes (-Gosselin 1976)
Ingestion: Yes (-Merck 1983)
Health Hazards (Acute, Delayed, and Chronic): The chemical is rated as
a very toxic compound with a probable oral lethal dose in humans of 50-500
mg/kg, or between 1 teaspoon and 1 ounce for a 70 kg (150 Ib.) person
(*Gosselin 1976) . It is a strong dermal irritant and frequently causes
dermatitis. Serious or fatal poisoning may result if large areas of skin
are wet with cresylic acid and the substance is not removed immediately
('"ACGIH 1980). Ingestion of even a small amount may cause paralysis and
coma (-Merck 1983). It is corrosive to body tissues (NFPA 1978, 49-32)
with toxicity similar to phenol (Encyc Occupat Health and Safety 1983,
p. 569).
Signs and Symptoms of Exposure: Exposure may result in a burning pain
in the mouth and throat; white necrotic lesions in the mouth, esophagus
and stomach; abdominal pain, vomiting, diarrhea, paleness; sweating;
weakness; headache; dizziness; ringing in ears; shallow respiration with
"phenol" odor on the breath; scanty, dark-colored or "smoky" urine; and
possibly delirium followed by unconsciousness. Convulsions are rarely
seen, except in children ("Gosselin 1976). Hypersensitivity develops in
certain individuals (Clayton and Clayton 1981-82, p. 2600).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush eyes with running water for at least 15 minutes ("DOT
1984) and wash the skin twice with soap and water (*Rumack 1975 to
Present). Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation ("DOT 1984).
SECTION VI -- USE INFORMATION
Chemical intermediate for phenolic and epoxy resins, sulfur chromium dyes,
herbicides, magnet wire coatings, and pharmaceuticals; disinfectant;
solvent; fiber treatment agent; tanning agent; and metal degreasing agent
(*SRI).
-------
CAS Registry Number: 95-48-7
Page 4 of 4
CRESYLIC ACID
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation. Wear proper respiratory protection and eye protection
(see Section V above). Keep unnecessary people away; isolate the hazard
area and deny entry. Wear protective clothing. Do not touch spilled
material. Stop leak if you can do so without risk. Use water spray to
reduce vapors. For small spills, absorb the material with sand or other
noncombustible absorbent material and place into containers for later
disposal. For small dry spills, shovel up and place into clean, dry
containers and cover. For large spills, dike far ahead of spill for later
disposal. If clothing becomes contaminated remove immediately and isolate
at the site (*DOT 1984). If a leak or spill has not ignited, use water
spray to disperse the vapors and to provide protection for personnel
attempting to stop a leak. Water spray may be used to flush spills away
from exposures (NFPA 1978, p. 49-32).
-------
CAS Registry Number: 95-63-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PSEUDOCUMENE
CAS Registry Number: 95-63-6
Synonyms: 1,2,4-Trimethylbenzene; 1,2,5-Trimethylbenzene;
1,3,4-Trimethylbenzene; as-Trimethylbenzene; Asymmetrical Trimethylbenzene;
Benzene, 1,2,4-Trimethyl-; Benzene, 1,2,5-Trimethyl-; Pseudocumol; psi-Cumene;
uns-Trimethylbenzene
Chemical Formula: C H
Molecular Weight: 120.2
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 25 ppm, ca. 125 mg/m3; STEL 35 ppm, ca. 170 mg/m3
for individual isomers or mixtures (*ACGIH 1980b)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD1 oral (rat)
5000 mg/kg; LC inhalation (rat) 0.018 mg/liter/4 hours (*NIOSH/RTECS
1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 336-340°F, 169-171°C (*Merck 1976)
Specific Gravity (H20=l): 0.876 at 20°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: -47°F, -43.8°C (*Weast 1979)
Vapor Density (AIR=1): 4.15 (*NFPA 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (-Merck 1976)
Appearance and Odor: Liquid (*Merck 1976)
-------
CAS Registry Number: 95-63-6
Page 2 of 3
PSEUDOCUMENE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 130°F (*Hawley 1977)
Flammable Limits:
LEL: 0.9% by volume (*NFPA 1978)
UEL: 6.4% by volume (*NFPA 1978)
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray, or alcohol foam. Large fires: water spray, fog, or alcohol
foam (DOT 1984, Guide 26).
Special Fire Fighting Procedures: Moderate fire risk (*Hawley 1977).
Isolate area from public and deny entry. Wear self-contained breathing
apparatus and full protective clothing. Isolate for 1/2 mile in all
directions if tank car or truck is involved in fire. For massive fire in
cargo area, use unmanned hose holder or monitor nozzles; if this is
impossible, withdraw from area and let fire burn. Withdraw immediately in
case of rising sound from venting safety device or any discoloration of
tank due to fire (DOT 1984, Guide 26).
Unusual Fire and Explosion Hazards: Autoignition at 932°F (500°C)
("NFPA 1978). In the absence of precautions, flammable concentrations of
vapor may be present where liquid is used for solvent and thinner
operations (*Encyc Occupat Health and Safety 1971). Runoff to sewers may
create fire or explosion hazard (DOT 1984, Guide 26).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Flammable concentrations of vapors may be
present when liquids are used for solvent and thinners (*Encyc Occupat
Health and Safety 1971).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 95-63-6
Page 3 of 3
PSEUDOCUMENE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*NIOSH/RTECS 1985)
Skin: Systemic intoxication is not probable
(*ACGIH 1980) but liquid is a primary skin
irritant (*Rumack 1975 to Present)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Central nervous system
depressant; can cause chemical pneumonia. Delayed effects (especially in
exposed workers) -- anemia, disturbances of blood clotting (failure to
clot) (*ACGIH 1980a).
Signs and Symptoms of Exposure: Vomiting (oral exposure), depression,
convulsions, anxiety, difficulty in breathing if pneumonia and lung edema
occur (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Remove victim from source of
liquid or vapors. In case of contact with material, wash skin twice with
soap and water, flush eyes with running water for 15 minutes. If patient
is not breathing, give artificial respiration. If difficulty in
breathing, give oxygen (DOT 1984, Guide 26). If patient is conscious and
has taken substance orally, give syrup of ipecac. Remove contaminated
clothing (-Rurnack 1975 to Present).
SECTION VI -- USE INFORMATION
Chief use is as solvent and paint thinner (*Encyc Occupat Health and
Safety 1971). Manufacture of trimellitic anhydride, pharmaceuticals and
pseudocumidine (*Hawley 1977). Also used to sterilize catgut and in the
manufacture of dyes, perfumes, and resins (*Merck 1976). Not a registered
pesticide in the U.S. (USEPA/Active Ingredients 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact; wear proper respiratory protection (see
Section V above). Shut off ignition sources and forbid smoking, flares,
or flames in hazard area. Stop leak if you can do so without risk. Use
water spray to reduce vapors. Small spills: take up with sand or other
noncombustible absorbent material and place into containers for future
disposal. Large spills: dike ahead of spill for later disposal (DOT
1984, Guide 26).
-------
CAS Registry Number: 97-18-7
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- PHENOL, 2,2'-THIOBIS(4,6-DICHLORO-
CAS Registry Number: 97-18-7
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 3, p. 77): Actamer; Bidiphen;
bis(2-Hydroxy-3,5-Dichlorophenyl) Sulfide; Bithionol; Bithionol Sulfide;
Bitin; CP 3438; 2,2*-Dihydroxy-3,3*,5,5'-Tetrachlorodiphenylsulfide;
2-Hydroxy-3,5-Dichlorophenyl Sulphide; Lorothidol; Lorothiodol; NCI-C60628;
Neopellis; TBP; USAF B-22; XL 7; 2,2'-Thiobis(4,6-Dichlorophenol); Vancide BL
Chemical Formula: C.-H.Cl.O.S
12 6 42
Molecular Weight: 356.04
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (rat) 7
mg/kg (*NIOSH/RTECS 1985) (SUSPECT)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
{2
Specific Gravity (H.0=l): 1.73 at 25°C/4°C (Merck 1983, p. 182)
Vapor Pressure (mmHg): 1.1 x 10"9 at 37°C (Merck 1983, p. 182)
Melting Point: 370°F, 188°C (Merck 1983, p. 182)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (Merck 1983, p. 182)
Appearance and Odor: White or grayish-white powder with an odorless to
phenolic odor (Hawley 1981, p. 137).
-------
CAS Registry Number: 97-18-7
Page 2 of 4
PHENOL, 2,2'-THIOBIS(4,6-DICHLORO-
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Decomposing heat (Sax 1984, p. 2567)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Emits very toxic fumes of
chlorine-containing compounds and sulfur oxides when heated to
decomposition (Sax 1984, p. 2567).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Yes (Non-Specific -- Phenol) (Gosselin 1976,
p. III-272)
Ingestion: Yes (Sax 1984, p. 2567)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
slightly toxic. Probable oral lethal dose for humans is 5-15 g/kg for a
70 kg (150 Ib) person. The toxicity of this compound is similar to that
of phenol (Gosselin 1984, p. 11-193). Major hazard of phenol poisoning
stems from its systemic effects which include central nervous system
depression with coma, hypothermia, loss of vasoconstricter tone, cardiac
depression and respiratory arrest (Gosselin 1984, p. III-345).
-------
CAS Registry Number: 97-18-7
Page 3 of 4
PHENOL, 2,2'-THIOBIS(4,6-DICHLORO-
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: (Non-Specific -- Phenol) Symptoms
include burning pain in mouth and throat; white necrotic lesions in mouth,
esophagus and stomach; abdominal pain; vomiting; bloody diarrhea;
paleness; sweating; weakness; headache; dizziness; tinnitus; scanty,
dark-colored urine; weak irregular pulse and shallow respiration
(Gosselin 1984, p. III-346).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Phenol, Solid)
Move victim to fresh air; call emergency medical care. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen. In
case of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Speed in removing material from skin is of
extreme importance. Remove and isolate contaminated clothing and shoes at
the site (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
It is used as a surfactant-formulated antimicrobial against bacteria,
molds and yeast. It is proposed as an agricultural fungicide (Merck 1983,
p. 182). Other uses include deodorant, germicide, fungistat and in the
manufacture of Pharmaceuticals (Hawley 1981, p. 137). It is no longer
allowed to be used in cosmetics (Merck 1983, p. 182). A food additive in
feed and drinking water of animals. Also a food additive permitted in
food for human consumption (Sax 1984, p. 2567).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Phenol, Solid) When handling wear positive pressure
breathing apparatus and special protective clothing. Keep unnecessary
people away and stay upwind. Do not touch spilled material. Use water
spray to reduce vapors. Absorb spills with non-combustible absorbent
material. For large spills dike far ahead for later disposal (DOT 1984,
Guide 55).
-------
CAS Registry Number: 97-18-7
Page 4 of 4
PHENOL, 2,2'-THIOBIS(4,6-DICHLORO-
COMMENTS:
Sources searched but no information found:
Hayes 1982
Farm Chemicals Handbook 1984
NFPA 1984
CHRIS 1978
Weiss 1980
Encyc of Occupat Health and Safety 1983
Student 1981
-------
CAS Registry Number: 98-05-5
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- BENZENEARSONIC ACID
CAS Registry Number: 98-05-5
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 542) Phenyl arsenic
acid; Phenylarsonic acid
Chemical Formula: C,H.,AsCL
o / j
Molecular Weight: 202.05
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 500 yg (arsenic)/m3 (NIOSH/RTECS 1983,
Volume 1, p. 542)
ACGIH TLV: 0.2 mg/m3, as Arsenic (Soluble Arsenic Compounds) (ACGIH
1984, p. 10)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD, oral (rat) 50
mg/kg; LD5Q oral (mouse) 0.27 rag/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 1.760 (Sax 1984, p. 362)
Vapor Pressure (mmHg): Not Found
Melting Point: 320°F, 160°C, decomposes (Sax 1984, p. 362)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in 40 parts water (Merck 1983, p. 151)
(Sax 1984, p. 362)
Appearance and Odor: Colorless solid (Sax 1984, p. 362).
-------
CAS Registry Number: 98-05-5
Page 2 of 4
BENZENEARSONIC ACID
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Arsenical Compound, Solid,
n.o.s.) This material does not burn or burns with difficulty. Extinguish
fire using agent suitable for surrounding fire (Student 1981, p. 51).
Special Fire Fighting Procedures: (Non-Specific -- Arsenical Compound,
Solid, n.o.s.) Use water in flooding quantities as fog. Avoid breathing
dusts and fumes; keep upwind; wear self-contained breathing apparatus
(Student 1981, p. 51).
Unusual Fire and Explosion Hazards: Benzenearsonic acid emits
poisonous fumes of arsenic when heated to decomposition (Sax 1984, p. 362).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition
(320°F), it emits toxic arsenic fumes (Sax 1984, p. 362).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Hawley 1981, p. 799)
-------
CAS Registry Number: 98-05-5
Page 3 of 4
BENZENEARSONIC ACID
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Benzenearsonic acid is a
deadly poison (Sax 1984, p. 342). (Non-Specific -- Arsenic Compounds)
Chronic exposure to arsenic compounds can cause dermatitis and digestive
disorders (Clayton and Clayton 1981-82, p. 1522). Renal damage may
develop (Gosselin 1981, p. 111-43).
Signs and Symptoms of Exposure: (Non-Specific -- Arsenic) Symptoms of
arsenic poisoning usually appear one-half to one hour after ingestion, but
may be delayed many hours. Symptoms include a sweetish metallic taste and
garlicky odor; difficulty in swallowing; abdominal pain; vomiting and
painful diarrhea; dehydration, thirst, and cramps; dizziness, stupor, and
delirium, rapid heart beat, headache, skin disorders, and coma (Gosselin
1981, p. 111-45).
Medical Conditions Generally Aggravated by Exposure:
Emergency and First Aid Procedures: (Non-Specific -- Arsenic Compound,
Solid, n.o.s.) Move victim to fresh air; call emergency medical care.
Remove and isolate contaminated clothing and shoes at the site. In case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes (DOT 1984, Guide 53).
SECTION VI -- USE INFORMATION
It is used as an analytical reagent for tin (Merck 1983, p. 151).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Arsenic Compound, Solid, n.o.s.) Keep unnecessary people
away; isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Wear self-contained (positive pressure if available) breathing
apparatus and full protective clothing. Do not touch spilled material;
stop leak if you can do it without risk. Small spills: take up with sand
or other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53).
-------
CAS Registry Number: 98-05-5
Page 4 of 4
BENZENEARSONIC ACID
COMMENTS
Sources searched but no information found:
ACGIH 1983
NIOSH/OSHA 1978
Weast 1979
NFPA 1984
Student 1981
Weiss 1980
CHRIS 1978
Arena 1979
-------
CAS Registry Number: 98-07-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- BENZOTRICHLORIDE
CAS Registry Number: 98-07-7
Synonyms: Toluene, alpha,alpha,alpha-Trichloro-; (Trichloromethyl)Benzene;
l-(Trichloromethyl) Benzene; alpha,alpha,alpha-Trichlorotoluene; Benzene,
(Trichloromethyl)-; Benzenyl Chloride; Benzenyl Trichloride; Benzoic
Trichloride; Benzyl Trichloride; Benzylidyne Chloride; omega,omega,omega-
Trichlorotoluene; Phenylchloroform; Phenyltrichloromethane; Toluene
Trichloride; Trichloromethylbenzene; Trichlorophenylmethane
Chemical Formula: c H.C1
Molecular Weight: 195.48
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC _ inhalation
(mouse) 0.064 mg/liter/2 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 429.4°F, 220.8°C (*Merck 1983)
<2
Specific Gravity (H.0=l): 1.3756 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): 1 at 45.8°C; 10 at 87.6°C (*Weast 1979)
Melting Point: 23°F, -5.0°C (*Merck 1983)
Vapor Density (AIR=1): 6.77 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Merck 1983)
-------
CAS Registry Number: 98-07-7
Page 2 of 3
BENZOTRICHLORIDE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Material is a clear, colorless to yellowish, oily
liquid with a penetrating odor (*IARC 1972-1985; *Sax 1979; »Hawley 1981)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 260°F, 127°C (CC) (*NFPA 1978)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray, or foam. Large fires: water spray, fog, or foam. Cool
containers that are exposed to flames with water from the side until well
after the fire is out (DOT 1984, Guide 60).
Special Fire Fighting Procedures: Wear self-contained breathing
apparatus and full protective clothing (DOT 1984, Guide 60). Normal fire
fighting procedures may be used (*NFPA 1978).
Unusual Fire and Explosion Hazards: This material may react violently
with water. Fire may produce irritating or poisonous gases.
Flammable/poisonous gases may accumulate in tanks and hopper cars.
Materials may ignite combustibles (wood, paper, oil, .etc.) (*DOT 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Merck 1983)
Stable:
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Similar to hydrochloric acid;
material will react with water or steam to produce toxic and corrosive
fumes (*Sax 1979). Hydrolyzes in presence of water forming benzoic and
hydrochloric acids (Hawley 1981, p. 119; *Merck 1983).
Hazardous Decomposition or Byproducts: Produces toxic and corrosive
fumes when it reacts with water or steam (*Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 98-07-7
Page 3 of 3
BENZOTRICHLORIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Sax 1975)
Skin: Not Found
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): Toxic by inhalation;
fumes are highly irritating to skin and mucous membranes ("Merck 1983,
Hawley 1981, p. 119). May cause death or permanent injury after very
short exposure to small quantities (*Sax 1975). A suspected carcinogen
(-Sorahan 1983).
Signs and Symptoms of Exposure: Highly irritating to skin and mucous
membranes (*Merck 1983).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. In case of contact with material, immediately
flush skin or eyes with copious amounts of running water for at least 15
minutes. Remove and isolate contaminated clothing and shoes at the site.
Keep victim quiet and maintain normal body temperature (DOT 1984, Guide
60).
SECTION VI -- USE INFORMATION
Synthetic dyes; organic synthesis (Hawley 1981, p. 119).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Material is extremely hazardous to health but areas may be entered with
extreme care. Full protective clothing including self-contained breathing
apparatus should be provided. No skin surface should be exposed (*NFPA
1978). Spilled material should not be touched. Take up spills with
noncombustible absorbent material. For large spills dike far ahead of
spill for later disposal (DOT 1984, Guide 60). Water should be used in
copious amounts because of reaction with water and formation of toxic
by-products (see Section IV above).
-------
CAS Registry Number: 98-09-9
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- BENZENESULFONYL CHLORIDE
CAS Registry Number: 98-09-9
Synonyms: Benzene sulfochloride; Benzene Sulfonechloride; Benzenesulfonic
(acid) chloride; Benzenesulfonic chloride; Benzenesulphonyl chloride;
Benzenosulphochloride; Phenylsulfonyl chloride
Chemical Formula: C,HCC10.S
65 2
Molecular Weight: 176.62
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat) 0.23 mg/liter/1 hour (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 483-486°F, 251-252°C at 760 mmHg (decomposes) (Merck
1983, p. 152)
Specific Gravity (H20=l): 1.3842 at 15°C/15°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: 58°F, 14.5°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble in water (-Merck 1976)
Appearance and Odor: Colorless, oily liquid (Merck 1983, p. 152)
-------
CAS Registry Number: 98-09-9
Page 2 of 3
BENZENESULFONYL CHLORIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with dry chemicals, carbon dioxide
and water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Wear positive pressure breathing
apparatus and special protective clothing. Fight fire from maximum
distance. Dike fire control water for later disposal; do not scatter the
material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: May burn but will not ignite
readily. Cylinder may explode in heat of fire (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Reacts vigorously with dimethyl
sulfoxide and methyl formamide (Sax 1984, p. 367).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of chlorides and sulfur oxides (Sax 1984, p. 367).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 367)
Skin: Yes (DOT 1984, Guide 55)
Ingestion: Yes (DOT 1984, Guide 55)
Health Hazards (Acute, Delayed, and Chronic): It is poisonous; may be
fatal if inhaled, swallowed or absorbed through the skin; contact may
cause burns to skin and eyes (DOT 1984, Guide 55). Reversible toxic
damage to the liver is possible after dermal exposure (*Stasik 1975).
-------
CAS Registry Number: 98-09-9
Page 3 of 3
BENZENESULFONYL CHLORIDE
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Symptoms may include allergic
reactions, and severe shock (*Stasik 1975). Contact may cause burns to
skin and eyes (DOT 1984, Guide 55).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site (DOT 1984,
Guide 55).
SECTION VI -- USE INFORMATION
It is used as a chemical intermediate for benzenesulfonamides, thiophenol,
glybuzole (hypoglycemic agent), N-2-chloroethylamides, benzonitrile; for
its esters -- useful as insecticides, and miticides ("SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not breathe vapors. Wear proper respiratory protection, eye protection
and full protective clothing (see Section V above). Do not touch spilled
material; stop leak; use water spray to reduce vapors. Small spills:
take up with sand or other noncombustible absorbent material and place
into containers for later disposal. Small dry spills: with clean shovel
place material into clean, dry container and cover; move containers from
spill area. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 55).
COMMENTS
Sources searched but no information found:
Gilman 1985
Student 1981
Hayes 1982
Hawley 1981
Doull 1980
Farm Chemicals Handbook 1984
-------
CAS Registry Number: 98-13-5
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- TRICHLOROPHENYLSILANE
CAS Registry Number: 98-13-5
Synonyms: Silane, Trichlorophenyl-; Phenyltrichlorosilane; Phenyl
Trichlorosilane; Phenylsilicon Trichloride; Phenyltrichlorosilicane; Silane,
Phenyltrichloro-; Silicon Phenyl Trichloride
Chemical Formula: C,HcCl0Si
DO J
Molecular Weight: 211.55
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC-n inhalation
(mouse) 0.0003 mg/liter/2 hours (-NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 395°F, 201.5°C (*Weast 1979)
Specific Gravity (H20=l): 1.326 at 18°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): 7.36 (*NFPA 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Decomposes in water (*Weast 1979)
Appearance and Odor: Colorless liquid (*Weast 1979)
-------
CAS Registry Number: 98-13-5
Page 2 of 4
TRICHLOROPHENYLSILANE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 196°F (OC) (*Sax 1979)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Dry chemical, carbon dioxide, fog, or foam.
May react violently with water (DOT 1984, Guide 29).
Special Fire Fighting Procedures: Full protective clothing, including
self-contained breathing apparatus, coat, pants, gloves, boots, and bands
around legs, arms, and waist should be provided. No skin surface should
be exposed (*NFPA 1978). Move container from fire area if you can do so
without risk. Cool containers that are exposed to flames with water from
the side until well after fire is out. Withdraw immediately in case of
rising sound from venting safety device or any discoloration of tank due
to fire (DOT 1984, Guide 29).
Unusual Fire and Explosion Hazards: Do not get water inside
containers. Vapors may travel to ignition source and flash back. Runoff
to sewer may create fire or explosion hazard. Flammable/combustible
material; may be ignited by heat, sparks or flames. Container may explode
in heat of fire. Vapor explosion hazard indoors, outdoors or in sewers.
Runoff to sewer may create fire or explosion hazard (DOT 1984, Guide 29).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Hawley 1977)
Stable:
Conditions to Avoid: Readily hydrolyzed in water/moisture,
producing hydrochloric acid (*Hawley 1977). Avoid mixing with water
or exposing to moisture (*Sax 1979).
Incompatibility (Materials to Avoid): Do not mix with halogenated
compounds, because a trace quantity of free halogen may.cause violent
explosion (*Bretherick 1979). May react violently with water (DOT 1984,
Guide 29).
Hazardous Decomposition or Byproducts: Emits toxic chloride fumes when
heated to decomposition (Sax 1984, p. 2631).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 98-13-5
Page 3 of 4
TRICHLOROPHENYLSILANE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 2631)
Skin: Yes (Sax 1984, p. 2631)
Ingestion: Yes (Sax 1984, p. 2631)
Health Hazards (Acute, Delayed, and Chronic): Highly toxic; may cause
death or permanent injury after short inhalation exposure to small
quantity (*Sax 1975). Chemical burns to all exposed membranes and tissues
with severe tissue destruction. Inhalation -- lungs may fill up with
fluid or throat may swell causing suffocation. Eyes -- damage to corneas
may cause blindness. Delayed: after oral exposure stomach and intestines
may perforate or be obstructed by scar tissue (*Rumack 1975 to Present,
Gosselin 1984, pp. III-10-ll).
Signs and Symptoms of Exposure: Inhalation -- severe difficulty in
breathing, chest pains. Eye contact -- severe pain, swelling, cornea
damage. Skin contact severe burns and pain. Ingestion -- mild to
moderately severe oral and esophageal burns, with severe burns occurring
in stomach. Perforations and peritonitis may occur. Severe irritation
may produce spontaneous vomiting. Viscid white or blood-stained foamy
mucus and threads of tissue may appear in mouth ("Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air. If not
breathing, perform artifical respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Keep victim quiet and
maintain normal body temperature (DOT 1984, Guide 29). In case of oral
exposure, do not induce vomiting. Have patient drink 1-2 large glasses of
water or milk to dilute stomach contents, then give demulcents such as
milk, cornstarch, and water ("Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
Monomer for copolymers in water repellants, in electrical insulating
resins, in high temperature resins for paints (*SRI). Intermediate for
silicones (-Hawley 1977).
-------
CAS Registry Number: 98-13-5
Page 4 of 4
TRICHLOROPHEN VLSI LANE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Wear suitable eye protection. No skin surface should be exposed (see
Section V above). Isolate hazard area. Stay upwind; keep out of low
areas. Wear self- contained (positive pressure if available) breathing
apparatus and full protective clothing. Shut off ignition sources; no
flares, smoking, or flames in hazard area. Do not touch spilled material;
stop leak if you can do it without risk. Do not get water inside
container. Take up small spills with sand or other noncombustible
absorbent material and place into containers for later disposal. Dike far
ahead of large spills for later disposal (DOT 1984, Guide 29).
-------
CAS Registry Number: 98-16-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- BENZENAMINE, 3-(TRIFLUOROMETHYL)-
CAS Registry Number: 98-16-8
Synonyms: m-(Trifluoromethyl)aniline; l-Amino-3-(Trifluoromethyl)Benzene;
3-(Trifluofomethyl)Aniline; 3-(Trifluoromethyl)Benzenamine; 3-Aminobenzo-
trifluoride; alpha,alpha,alpha-Trifluoro-m-Toluidine; m-Amino-alpha,alpha,
alpha-Trifluorotoluene; m-Aminobenzotrifluoride; m-Toluidine,
alpha,alpha,alpha-Trifluoro-; Toluene, 3-Amino-alpha,alpha,alpha-Trifluoro-
Chemical Formula: C,H,F,N
/DO
Molecular Weight: 161.13
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat) 0.44 mg/liter/4 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 369.5°F, 187.5°C at 764 mmHg (*Weast 1979)
Specific Gravity (H20=l): 1.303 at 15.5°C (Sax 1984, p. 192)
Vapor Pressure (mmHg): Not Found
Melting Point: 37°F, 3°C (Sax 1984, p. 192)
Vapor Density (AIR=1): 5.56 (Sax 1984, p. 192)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (*Weast 1979)
-------
CAS Registry Number: 98-16-8
Page 2 of 4
BENZENAMINE, S-(TRIFLUOROMETHYL)-
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless to yellow oily liquid (*Hawley 1977)
with aniline-like odor (Sax 1984, p. 192).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Wear positive pressure breathing
apparatus and special protective clothing. Move container from fire area
if you can do so without risk. Fight fire from maximum distance. Dike
fire control water for later disposal; do not scatter the material (DOT
1984, Guide 55).
Unusual Fire and Explosion Hazards: This material may burn but does
not ignite readily. Cylinder may explode in heat of fire (DOT 1984, Guide
55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of fluorides and nitrogen oxides (Sax 1984, p.
192).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 98-16-8
Page 3 of 4
BENZENAMINE, 3-(TRIFLUOROMETHYL)-
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 192)
Skin: Yes (DOT 1984, Guide 55)
Ingestion: Yes (Sax 1984, p. 192)
Health Hazards (Acute, Delayed, and Chronic): Contact may cause burns
to skin and eyes. May be poisonous if inhaled, swallowed or absorbed
through the skin (DOT 1984, Guide 55).
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
This material is used as a chemical intermediate for herbicides,
antihypertensives, and diuretics ("SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Wear positive pressure breathing apparatus and special protective
clothing. Remove and isolate contaminated clothing at the site. If water
pollution occurs, notify appropriate authorities. Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand or other non-combustible
absorbent material and place into containers for later disposal. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 98-16-8
Page 4 of 4
BENZENAMINE, 3-(TRIFLUOROMETHYL)-
COMMENTS:
Sources searched but no information found:
ACGIH 1984
NIOSH/OSHA 1978
Hawley 1981
Merck 1983
NFPA 1984
Student 1981
Weiss 1980
CHRIS 1978
Doull 1980
Clayton and Clayton 1981-82
Arena 1979
Gosselin 1984
Encyc Occupat Health & Safety 1983
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
Physicians' Desk Reference 1985
Oilman 1985
-------
CAS Registry Number: 98-87-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- BENZAL CHLORIDE
CAS Registry Number: 98-87-3
Synonyms: (Dichloromethyl)Benzene; alpha,alpha-Dichlorotoluene; Benzene,
(Dichloromethyl)-; Benzyl Dichloride; Benzylene Chloride; Benzylidene
Chloride; Chlorobenzal; Dichlorophenylmethane; Toluene, alpha,alpha-Dichloro-
Chemical Formula: C_H,C1.
/ D /
Molecular Weight: 161.03
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC_0 inhalation
(mouse) 0.21 mg/liter/2 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 401°F, 205°C (*Merck 1983)
Specific Gravity (H20=l): 1.26 (*Merck 1983)
Vapor Pressure (mmHg): 1 at 35.4°C (Weast 1979, p. D-209)
Melting Point: 2.48°F, -16.4°C (Weast 1979, p. C-523)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble in water (*Merck 1983)
Appearance and Odor: Colorless oily liquid with a faint aromatic odor
(*Hawley 1981) or pungent odor (*Merck 1983)
-------
CAS Registry Number: 98-87-3
Page 2 of 3
BENZAL CHLORIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: This material may burn but will not ignite easily
(-DOT 1984).
LEL: Not Found
DEL: Not Found
Extinguishing Methods: For small fires: dry chemical, carbon dioxide,
water spray, or foam. For large fires: water spray, fog, or foam. Move
container from fire area if possible. Fight fire from maximum distance.
Dike fire control water for later disposal; do not scatter the material
(*DOT 1984).
Special Fire Fighting Procedures: Keep unnecessary people away and
isolate hazard area. Stay upwind and keep out of low areas. Wear
positive pressure breathing apparatus and special protective clothing
(*DOT 1984).
Unusual Fire and Explosion Hazards: Fire may produce irritating or
poisonous gases. Runoff from fire control water may give off poisonous
gases and may cause pollution. Cylinder may explode in the heat of fire
(*DOT 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Reacts with water to release
hydrochloric acid (*Grant 1974).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-DOT 1984)
Skin: Yes (*DOT 1984)
Ingestion: Yes (-DOT 1984)
-------
CAS Registry Number: 98-87-3
Page 3 of 3
BENZAL CHLORIDE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Acute: vapors are
highly irritating to eyes (''"Grant 1974). May be fatal if inhaled,
swallowed, or absorbed through skin (-DOT 1984).
Signs and Symptoms of Exposure: Eye irritation occurs upon exposure
(''-Grant 1974).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. If not breathing give artificial respiration; if
breathing is difficult give oxygen. In case of contact, immediately flush
skin or eyes with water for at least 15 minutes. Speedy removal from skin
is essential. Remove and isolate contaminated clothing and shoes at the
site. Keep victim quiet and maintain normal body temperature. Keep a
careful watch since effects may be delayed (*DOT 1984).
SECTION VI -- USE INFORMATION
Used in dyes and in the manufacture of benzaldehyde and cinnamic acid
(*Hawley 1981).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not breathe vapors. Wear eye protection and proper respiratory
protection. Wear full protective clothing (see Section V above). For
spills or leaks, do not touch material. Stop leak if possible. Use water
spray to reduce vapors. For s"iall spills, take up with sand or other
noncombustible material and place in containers for later disposal. For
small dry spills, place material in clean dry container with shovel and
move containers from spill area. For large spills, dike far ahead of
spills for later disposal (-DOT 1984).
-------
CAS Registry Number: 98-95-3
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- NITROBENZENE
CAS Registry Number: 98-95-3
Synonyms: Benzene, Nitro-; Essence of Mirbane; Essence of Myrbane; Mirbane
Oil; NCI-C60082; Nitrobenzol; Oil of Mirbane; Oil of Myrbane
Chemical Formula: C,HCNO-
DO Z
Molecular Weight: 123.11
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 1 ppm (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 1 ppm (5 mg/m3); STEL 2 ppm (10 mg/m3) (skin)
(*ACGIH 1980)
IDLH: 200 ppm (NIOSH/OSHA 1978, p. 140)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 411.4°F, 210.8°C (*Weast 1979)
Specific Gravity (H20=l): 1.2^37 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): 1 at 44.4°C ("Sax 1979)
Melting Point: 42°F, 5.7°C (*Weast 1979)
Vapor Density (AIR=1): 4.3 (NFPA 1984, p. 325M-74)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in about 500 parts water ('"Merck 1976)
Appearance and Odor: Greenish-yellow crystals or yellow, oily liquid
(-Hawley 1977) with an odor of volatile oil almond (-Merck 1976).
-------
CAS Registry Number: 98-95-3
Page 2 of 4
NITROBENZENE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 88°C (CC) (*Sunshine 1969)
Flammable Limits:
LEL: 1.8% (-Encyc Occupat Health and Safety 1971)
DEL: Not Found
Extinguishing Methods: Use water spray, dry chemical, foam, or carbon
dioxide (NFPA 1984, pp. 49-67).
Special Fire Fighting Procedures: Move container from fire area if you
can do it without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material. Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Ventilate closed spaces before entering them.
Wear positive pressure breathing apparatus and special protective
clothing. Remove and isolate contaminated clothing at the site (DOT 1984,
Guide 55).
Unusual Fire and Explosion Hazards: Moderate explosion hazard when
exposed to heat -or flame. Reacts violently with nitric acid, aluminum
trichloride plus phenol, aniline plus glycerine, silver perchlorate and
nitrogen tetroxide (Sax 1984, p. 2010).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-NFPA 1978)
Conditions to Avoid: Sunlight (*Sax 1975), physical damage to
container, freezing, and intense heat (NFPA 1984, pp. 49-67).
Incompatibility (Materials to Avoid): Aluminum trichloride; aniline;
gycerol; sulfuric acid; oxidants; phosphorus pentachloride; potassium;
potassium hydroxide (Sax 1984, p. 2010)
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Gosselin 1976)
Skin: Yes (*Gosselin 1976)
.Ingestion: Yes (*Gosselin 1976)
-------
CAS Registry Number: 98-95-3
Page 3 of 4
NITROBENZENE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Can cause death due to
respiratory failure ("Arena 1974). Classified as extremely toxic. The
mean lethal oral dose is probably between 1 and 5 grams. Systemic effects
may be delayed for a few hours (Gosselin 1984, p. 11-214). This compound
is rapidly absorbed through the skin (Merck 1983, p. 945). It is a
powerful methemoglobin former ("Patty 1963).
Signs and Symptoms of Exposure: Common symptoms include euphoria,
flushed face, headache, weakness, dizziness, nausea, vomiting, disturbed
vision, lightheadedness, incoordination, shortness of breath, labored
breathing, and an alarming bluing of skin, lips, and fingernail bed.
Severe exposures can cause stupor, coma and death due to respiratory
failure ("Hamilton 1974, -Arena 1974).
Medical Conditions Generally Aggravated by Exposure: Ethyl alcohol
aggravates intoxication caused by nitrobenzene exposure (Gosselin 1984, p.
11-214).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Used as a solvent for cellulose ethers; modifying esterification of
cellulose acetate; ingredient of metal polishes (*Hawley 1977), in soaps
and shoe polishes; for refining lubricating oils; manufacturing of
pyroxylin compound ("Merck 1976); a preservative in spray paints;
constituent of floor polishes; substitute for almond essence; in perfume
industry (^Browning 1965); chemical intermediate for aniline and
dichloroanilines ("SRI). Registered as an insecticide for use on cadavers
(USEPA/Pesticide Index 1985).
-------
CAS Registry Number: 98-95-3
Page 4 of 4
NITROBENZENE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Wear positive pressure breathing apparatus and special protective
clothing. Remove and isolate contaminated clothing at the site. Do not
touch spilled material; stop leak if you can do it without risk. Use
water spray to reduce vapors (DOT 1984, Guide 55). Absorb spilled
materials in vermiculite, dry sand, earth, or similar material, and place
in sealed containers for disposal in secured sanitary landfill
(*NIOSH/OSHA 1981).
-------
CAS Registry Number: 99-98-9
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DIMETHYL-p-PHENYLENEDIAMINE
CAS Registry Number: 99-98-9
Synonyms: N,N-Dimethyl-p-Benzenediamine; 1,4-Benzenediamine,
N,N-Dimethyl-; 4-(Dimethylamino)Aniline; 4-Amino-N,N-Dimethylaniline; CI
76075; Dimethyl-para-Phenylenediamine; Dimethyl-paraphenylenediamine; DMPD;
N,N-Dimethyl-l,4-Benzenediamine; N,N-Dimethyl-l,4-Phenylenediaraine;
N,N-Dimethyl-p-Phenylenediamine; p-(Dimethylamino)Aniline; p-Amino-N,N-
Diraethylaniline; p-Aminodimethylaniline; p-Dimethylaminophenylamine;
p-Phenylenediamine, N,N-Dimethyl-
Chemical Formula: C0H,,.N0
o lz /
Molecular Weight: 136.22
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC^ inhalation
(guinea pig) 0.0013 mg/liter (-NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 504°F, 262°C (*Merck 1976)
Specific Gravity (H20=l): 1.036 at 20/4°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: 127°F, 53°C (*Merck 1976); also stated as 106°F, 41°C
(Merck 1983, p. 474)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 99-98-9
Page 2 of 3
DIMETHYL-p-PHENYLENEDIAMINE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Soluble (*Merck 1976)
Appearance and Odor: Colorless to reddish-violet solid (*Hawley 1977,
*Merck 1976)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of nitrogen oxides (Sax 1984, p. 1190).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-Hawley 1977)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of nitrogen oxides (Sax 1984, p. 1190).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Hawley 1977)
Skin: Yes (Sax 1984, p. 1190)
Ingestion: Yes (*Hawley 1977)
-------
CAS Registry Number: 99-98-9
Page 3 of 3
DIMETHYL-p-PHENYLENEDIAMINE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Lowest toxic dose with
skin effect is 14 yg/kg ("NIOSH/RTECS 1985). Irritant to skin and eyes
(*Hawley 1977).
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Treatment is as for general
poisoning. Seek medical attention. Establish respiration. Prevent
absorption. Induce vomiting. In case of skin contamination decontaminate
with water and soap. In case of eye exposure, flush thoroughly with water
(-Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
Used in the production of methylene blue and photodeveloper. It is a
reagent for hydrogen sulfide, cellulose, organic synthesis (*Hawley
1977). Chemical intermediate for dyes and diazonium chloride salts;
analytical reagent for chloroamine detection in water ("SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Nonspecific -- Phenylenediamine). Do not touch material; stop leak if it
can be done without risk. Keep unnecessary people away. Isolate area and
deny entry. Stay upwind and out of low areas. Wear self-contained
(positive pressure, if available) breathing apparatus and full protective
clothing. For small spills, use shovel to place material into clean, dry
container and cover; move containers from spill area. For large spills,
dike far ahead to collect for later disposal (DOT 1984, Guide 53).
-------
CAS Registry Number: 100-14-1
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- BENZENE, 1-(CHLOROMETHYL)-4-NITRO-
CAS Registry Number: 100-14-1
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 3, page 771): p-Nitro-
benzyl Chloride; Toluene, alpha-Chloro-p-Nitro-; alpha-Chloro-p-Nitrotoluene
Chemical Formula: C_H,C1N00
/ o 2.
Molecular Weight: 171.59
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat) 0.28 mg/liter/4 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H.0=l): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 159.8°F, 71°C (Weast 1979, p. C-522)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (Weast 1979, p. C-522)
Appearance and Odor: Not Found
-------
CAS Registry Number: 100-14-1
Page 2 of 3
BENZENE, 1-(CHLOROMETHYL)-4-NITRO-
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This material may burn but does not ignite
readily. Small fires: dry chemical, carbon dioxide, water spray or
foam. Large fires: Water spray, fog or foam. Move container from fire
area if you can do it without risk (DOT 1984, Guide 53).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Wear self-contained (positive pressure if available) breathing apparatus
and full protective clothing (DOT 1984, Guide 53).
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Incompatible with sodium
hydroxide (Sax 1984, p. 748).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 748)
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 748)
Health Hazards (Acute, Delayed, and Chronic): Poisonous if swallowed
or dust is inhaled (DOT 1984, Guide 53).
-------
CAS Registry Number: 100-14-1
Page 3 of 3
BENZENE, 1-(CHLOROMETHYL)-4-NITRO-
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. Remove and isolate contaminated clothing and
shoes at the site. In case of contact with material, immediately flush
skin and eyes with running water for at least 15 minutes (DOT 1984, Guide
53).
SECTION VI -- USE INFORMATION
Not Found
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Wear self-contained (positive pressure if
available) breathing apparatus and full protective clothing. If water
pollution occurs, notify appropriate authorities. Do not touch spilled
material; stop leak if you can do so without risk. Small spills: absorb
with sand or other noncombustible absorbent material and place into
containers for later disposal. Small dry spills: with clean shovel,
place material into clean, dry container and cover; move containers from
spill area. Large spills: dike far ahead of spill for alter disposal
(DOT 1984, Guide 53).
COMMENTS
Sources searched but no information found:
Hawley 1981
Merck 1983
Student 1981
Weiss 1980
Doull 1980
Clayton and Clayton 1981-82
Gosselin 1984
Encyc Occupat Health and Safety 1983
-------
CAS Registry Number: 100-44-7
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- BENZYL CHLORIDE
CAS Registry Number: 100-44-7
Synonyms: (Chloromethyl)Benzene; alpha-Chlorotoluene; Benzene,
(Chloromethyl)-; Chloromethylbenzene; Chlorophenylmethane; NCI-C06360;
omega-Chlorotoluene; Toluene, alph.a-Ch.loro-; Tolyl Chloride
Chemical Formula: C H_C1
Molecular Weight: 126.58
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 1 ppm (5 mg/m3) (OSHA 1984, p. 661)
ACGIH TLV: TWA 5 mg/m3 (*ACGIH 1984)
IDLH: 10 ppm (-Encyc Occupat Health and Safety 1983)
Other Limits Recommended: Occupational exposure recommended standard
-- air: ceiling concentration 5 mg/m3/15 minutes (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 354°F, 179°C (*Merck 1983)
Specific Gravity (H20=l): 1.100 at 20°C/20°C (*Merck 1983)
Vapor Pressure (mmHg): 1 at 22°C (*IARC 1985)
Melting Point: -45 to -54°F, -43 to -48°C (*Merck 1983)
Vapor Density (AIR=1): 4.4 (*NFPA 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Merck 1983)
Appearance and Odor: Colorless to slightly yellow liquid (*NFPA 1978);
irritating odor (-Merck 1983)
-------
CAS Registry Number: 100-44-7
Page 2 of 4
BENZYL CHLORIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 153°F, 67°C (CC) (*NFEA 1978)
Flammable Limits:
LEL: 1.1% (*NFPA 1978)
UEL: Not Found
Extinguishing Methods: Use water spray, dry chemical, foam, or carbon
dioxide (*NFPA 1978). Use water to keep fire-exposed containers cool
(*NFPA 1978).
Special Fire Fighting Procedures: Areas may be entered freely with
full-faced mask, self-contained breathing apparatus which provides eye
protection, rubber gloves, and hand and arm protection (*NFPA 1978).
Unusual Fire and Explosion Hazards: It burns but does not ignite
readily. It may ignite combustibles (DOT 1984, Guide 59).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-NFPA 1978)
Conditions to Avoid: Keep separate from oxidizing materials ("Sax
1979). May become unstable at elevated temperatures and pressures;
may react with water resulting in some nonviolent release of energy
('''NFPA 1978).
Incompatibility (Materials to Avoid): Incompatible with active metals
such as copper, aluminum, magnesium, iron, zinc, and tin and keep from
strong oxidizing agents (NIOSH/OSHA 1978, p. 50). Avoid acids or acid
fumes (*Sax 1979).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic and corrosive fumes. Some organic chlorides decompose to
yield phosgene (*Sax 1978).
Hazardous Polymerization: May Occur: Yes (*CHRIS 1978)
May Not Occur:
Conditions to Avoid: Polymerizes with evolution of heat and
hydrogen chloride when in contact with all common metals except nickel
and lead ('-CHRIS 1978).
-------
CAS Registry Number: 100-44-7
Page 3 of 4
BENZYL CHLORIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes ("Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): Intensely irritating to
skin, eyes, and mucous membranes (*Merck 1983). Highly toxic; may cause
death or permanent injury after very short exposure to small quantities
(*Sax 1975). Has been listed as a direct-acting or primary carcinogen
(*Doull 1980). Large doses cause central nervous system depression
(*Merck 1983).
Signs and Symptoms of Exposure: Inhalation exposure may result in
severe irritation of upper respiratory tract with coughing, burning of the
throat, headache, dizziness, and weakness. Eye contact may result in
immediate and severe eye irritation and prolonged exposure may cause
permanent eye damage. Ingestion may cause severe burns of the mouth,
throat, and gastrointestinal tract resulting in nausea, vomiting, cramps,
and diarrhea (Weiss 1980, p. 155).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: For inhalation remove from
contaminated atmosphere; if not breathing start mouth-to-mouth
resuscitation; give oxygen if available; keep patient warm and
comfortable; call for medical treatment. Upon eye contact, immediately
flush with large quantities of running water for at least 15 minutes and
call for medical attention. Immediately flush contaminated areas of skin
with water and remove contaminated clothing. After ingestion give large
amounts of water and do not induce vomiting (Weiss 1980, p. 155).
SECTION VI -- USE INFORMATION
It is used in the manufacturing of perfumes, pharmaceutical products,
dyes, synthetic tannins, artificial resins, (*Merck 1983) photographic
developer, gasoline gum inhibitors, penicillin precursors (*Hawley 1981).
Also, benzyl chloride is used as an intermediate in the manufacture of
other organic chemicals (*SRI). In the past, it was used as an irritant
gas in chemical warfare (*IARC 1972-1985).
-------
CAS Registry Number: 100-44-7
Page 4 of 4
BENZYL CHLORIDE
SECTION VII - PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
If leak or spill has not ignited, use water spray to disperse vapors and
to provide protection for persons attempting to stop leak. Use water
spray to flush spills away from exposures (*NFPA 1978). Take up small
spills with sand or other noncombustible absorbent material and place into
containers for later disposal. For larger spills, dike for later
disposal. Always wear positive pressure breathing apparatus and special
protective clothing (DOT 1984, Guide 59).
-------
CAS Registry Number: 102-36-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ISOCYANIC ACID, 3,4-DICHLOROPHENYL ESTER
CAS Registry Number: 102-36-3
Synonyms: 3,4-Dichlorophenyl Isocyanate; Benzene, l,2-Dichloro-4-
Isocyanato-
Chemical Formula: C H,C1 NO
Molecular Weight: 188.01
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(mouse) 0.14 mg/liter/2 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 244°F, 118°C at 18 mmHg (Beilstein 1954, Vol. 12/3, p.
1405)
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 113°F, 45°C (Beilstein 1954, Vol. 12/3, p. 1405)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: White to yellow solid (*Hawley 1977)
-------
CAS Registry Number: 102-36-3
Page 2 of 3
ISOCYANIC ACID, 3,4-DICHLOROPHENYL ESTER
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog, or foam. Move container from fire area if you can do so
without risk (DOT 1984, Guide 53).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Wear self-contained (positive pressure if available) breathing apparatus
and full protective clothing (DOT 1984, Guide 53).
Unusual Fire and Explosion Hazards: Inhalation of dust poisonous; fire
may produce irritating or poisonous gases (DOT 1984, Guide 53).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (DOT 1984, Guide 53)
Skin: Not Found
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Strong irritant to
tissue, especially eyes and mucous membranes (*Hawley 1977)
Signs and Symptoms of Exposure: Not Found
-------
CAS Registry Number: 102-36-3
Page 3 of 3
ISOCYANIC ACID, 3,4-DICHLOROPHENYL ESTER
I
SECTION V -- HEALTH HAZARD DATA (Continued)
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. Remove and isolate contaminated clothing and
shoes at the site. In case of contact with material, immediately flush
skin or eyes with running water for at least 15 minutes (DOT 1984, Guide
53).
SECTION VI -- USE INFORMATION
Chemical intermediate; organic synthesis (*Hawley 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation of dust (see Section V above). Do not touch spilled
material; stop leak if you can do so without risk. Small spills: absorb
with sand or other noncombustible absorbent material and place into
containers for later disposal. Small dry spills: with clean shovel place
material into clean, dry container and cover; move containers from spill
area. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 53).
-------
CAS Registry Number: 103-85-5
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PHENYLTHIOUREA
CAS Registry Number: 103-85-5
Synonyms: Urea, l-Phenyl-2-Thio-; l-Phenyl-2-Thiourea; 1-Phenylthiourea;
alpha-Phenylthiourea; N-Phenylthiourea; NCI-C02017; Phenylthiocarbamide; PTC;
PTU; Thiourea, Phenyl-; U6324; USAF EK-1569
Chemical Formula: CLH0NnS
/ o /
Molecular Weight: 152.22 (-Merck 1983)
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (rat) 3
mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 1.3 (*Merck 1983)
Vapor Pressure (mmHg): Not Found
Melting Point: 309°F, 154°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in 400 parts cold water; 17 parts boiling
water (*Merck 1983).
Appearance and Odor: Needle-like crystals (Sax 1984, p. 2205).
-------
CAS Registry Number: 103-85-5
Page 2 of 3
PHENYLTHIOUREA
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Dangerous disaster hazard; emits
toxic fumes of oxides of sulfur and nitrogen when heated to decomposition
(Sax 1984, p. 2205).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Acid or acid fumes (Sax 1984,
p. 2205)
Hazardous Decomposition or Byproducts: When heated to decomposition,
or on contact with acid or acid fumes it emits highly toxic fumes of
sulfur oxides and nitrogen oxides (Sax 1984, p. 2205).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (Sax 1984, p. 2205)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
extremely toxic. The probable oral lethal dose is 5-50 mg/kg or between 7
drops and 1 teaspoon for a 70 kg (150 Ib.) person (*Gosselin 1976).
-------
CAS Registry Number: 103-85-5
Page 3 of 3
PHENYLTHIOUREA
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Exposure may result in vomiting,
difficult breathing, noisy breathing, cyanosis, and low body temperature
(••-Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Phenylthiourea is similar to Antu
(Gosselin 1984, p. 11-350). Dermal exposure: wash exposed area twice
with soap and water. Eye exposure: wash copiously with water for 15
minutes. Inhalation: remove to fresh air (*Rumack 1975 to Present).
Oral: Induce vomiting (Gosselin 1984, p. 111-41).
SECTION VI -- USE INFORMATION
Used in the manufacture of rodenticides ("Gosselin 1976) and in medical
genetics (Merck 1983, p. 1794).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation or contact with skin (see Section V above). Use
self-contained breathing apparatus in presence of toxic fumes resulting
from decomposition (Sax 1984, p. 2205).
-------
CAS Registry Number: 106-89-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- EPICHLOROHYDRIN
CAS Registry Number: 106-89-8
Synonyms: (Chloromethyl)Ethylene Oxide; (DL)-alpha-Epichlorohydrin;
l,2-Epoxy-3-Chloropropane; l-Chloro-2,3-Epoxypropane; 2,3-Epoxypropyl
Chloride; 3-Chloro-l,2-Epoxypropane; 3-Chloro-l,2-Propylene Oxide;
Alpha-Epichlorohydrin; Chloromethyloxirane; Chloropropylene Oxide; ECH;
Epichlorophydrin; Epichlorhydrin; gamma-Chloropropylene Oxide; Glycerol
Epichlorhydrin; Glycerol Epichlorohydrin; Glycidyl Chloride; NCI-C07001;
Oxirane, (Chloromethyl)-; Oxirane, 2-(Chloromethyl); SKEKHG
Chemical Formula: C H5C10
Molecular Weight: 92.53
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 5 ppm (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 2 ppm (8 mg/ra3); STEL 5 ppm (19 mg/m3) (skin)
(*ACGIH 1980)
IDLH: 100 ppm (NIOSH/OSHA 1978, p. 92)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 241.7°F, 116.5°C (-Weast 1979)
Specific Gravity (H20=l): 1.801 at 20°C/4°C (*Weast 1979); 1.18 at
20°C (Merck 1983, p. 520)
Vapor Pressure (mmHg): 10 at 16.6°C (*Sax 1975)
Melting Point: -54.4°F, -48°C (-Weast 1979); -14.1°F, -25.6°C (Merck
1983, p. 520)
Vapor Density (AIR=1): 3.29 (*Sax 1975)
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 106-89-8
Page 2 of 4
EPICHLOROHYDRIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Insoluble in water (*Merck 1976)
Appearance and Odor: Colorless liquid (*Sax 1975) with a pungent,
garlic, sweet odor (*CHRIS 1978).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 93°F(CC) (*ACGIH 1980); 105°F(OC) (*Merck
1983)
Flammable Limits:
LEL: 3.8% (*NFPA 1978)
UEL: 21.0% (*NFPA 1978)
Extinguishing Methods: Use water spray, dry chemical, foam or carbon
dioxide. Water spray may be used to dilute spills to non-flammable
mixtures. If leak or spill has not ignited, use water spray to disperse
the vapors. Keep fire-exposed containers cooled with water (*NFPA 1978).
Special Fire Fighting Procedures: If fire becomes uncontrollable, or
containers are exposed to direct flames, evacuate for a radius of 1,500
feet ("'Student 1981). Isolate for one-half mile in all directions if tank
car or truck is involved in fire (DOT 1984, Guide 30). Epichlorohydrin
may react violently with water (*NFPA 1978).
Unusual Fire and Explosion Hazards: When heated to decomposition, this
compound evolves highly toxic fumes of phosgene (""Sax 1975) and carbon
monoxide (-General Electric Co. MSDS #3358 1979).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: Heat and contaminants (-NFPA 1978).
Incompatibility (Materials to Avoid): Reactive and incompatible with
strong oxidizers, strong acids, caustics, zinc, aluminum, chlorides of
iron and aluminum (NIOSH/OSHA 1978, p. 92), and compounds with an active
hydrogen atom, including water (*ITI 1982).
Hazardous Decomposition or Byproducts: When heated, can evolve fumes
of phosgene ("Sax 1975) and carbon monoxide (^General Electric Co. MSDS
#3358 1979).
-------
CAS Registry Number: 106-89-8
Page 3 of 4
EPICHLOROHYDRIN
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Yes (*CHRIS 1978)
May Not Occur:
Conditions to Avoid: Strong acids and bases (*CHRIS 1978); certain
curing agents such as ethylenediamine (^General Electric Co. 1979,
MSDS #335B).
SECTION V -- HEALTH HAZARD DATA
X
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes ('-Sax. 1975)
Health Hazards (Acute, Delayed, and Chronic): This compound is caustic
as both a liquid and gas. Irritation of the eyes and skin, and skin
sensitization has been observed (*LeFaux 1968; "Sax 1975). Exposure to
epichlorohydrin has caused inflammation of the lungs, asthmatic
bronchitis, and liver and kidney damage ("Gosselin 1976; *Sax 1975). In
acute poisonings, death may be caused by respiratory paralysis ("Sax 1975)
Signs and Symptoms of Exposure: Fatigue, gastrointestinal pain,
chronic conjunctivitis (*LeFaux 1968), tearing, asthmatic bronchitis
("Gosselin 1976), skin sensitization and burns (*ACGIH 1971-79) have all
been described.
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 30).
SECTION VI -- USE INFORMATION
Insect fumigant, solvent ("Merck 1976), raw material or intermediate for
chemical synthesis, cross-linking agent, heat stabilizer for plastics,
comonomer for epoxy resins (*SRI), papermaking additive (*Kirk-Othmer
1978). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index
1985).
-------
CAS Registry Number: 106-89-8
Page 4 of 4
EPICHLOROHYDRIN
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Wear positive pressure breathing apparatus
and special protective clothing. Shut off ignition sources; no flares,
smoking or flames in hazard area. Do not touch spilled material; stop
leak if you can do it without risk. Use water spray to reduce vapors; do
not get water inside container. Small spills: flush area with flooding
amounts of water. Large spills: dike far ahead of spill for later
disposal (DOT 1984, Guide 30). In case of spill or leak from a drum or
smaller container or a small leak from a tank, isolate for 40 feet in all
directions. In case of a large spill from a tank or many containers,
first isolate for 80 feet in all directions, then evacuate in a downwind
direction an area 0.2 miles wide and 0.3 miles long (DOT 1984, Table of
Isolation and Evacuation Distances).
-------
CAS Registry Number: 106-96-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PROPARGYL BROMIDE
CAS Registry Number: 106-96-7
Synonyms: Propyne, 3-Bromo-; gamma-Bromoallylene; 3-Bromopropyne;
3-Bromo-l-propyne
Chemical Formula :C H Br
Molecular Weight: 118.97
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (rat) 53
mg/kg; LD5Q oral (guinea pig) 0.029 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 190-194°F, 88-90°C (Sax 1984, p. 2295)
Specific Gravity (H 0=1): 1.564-1.570 (Sax 1984, p. 2295)
Vapor Pressure (mmHg): Not Found
Melting Point: -77.9°F, -61.07°C (Sax 1984, p. 2295)
Vapor Density (AIR=1): 6.87 (Sax 1984, p. 2295) (SUSPECT)
Evaporation Rate (Butyl acetate=l):. Not Found
Solubility in Water: Not Found
Appearance and Odor: Colorless liquid, sharp odor (Sax 1984, p. 2295)
-------
CAS Registry Number: 106-96-7
Page 2 of 3
PROPARGYL BROMIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 149°F, 65°C (CC) (Sax 1984, p. 2295)
Flammable Limits:
LEL: 3.0% (-NFPA 1978)
UEL: Not Found
Extinguishing Methods: Use water, foam, carbon dioxide, or dry
chemical (Sax 1984, p. 2295)
Special Fire Fighting Procedures: Wear self-contained breathing
apparatus and full protective clothing. Move container from fire area if
you can do it without risk. Do not get water inside container. Cool
containers that are exposed to flames with water from the side until well
after fire is out. Withdraw immediately in case of rising sound from
venting safety device or any discoloration of tank due to fire. Isolate
for 1/2 mile in all directions if tank car or truck is involved in fire
(DOT 1984, Guide 29).
Unusual Fire and Explosion Hazards: This material detonates at 428°F,
220°C or more; ignites by impact. Emits highly toxic fumes of bromides
when heated to decomposition (Sax 1984, p. 2295).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (Sax 1984, p. 2295)
Stable:
Conditions to Avoid: Heat, flame, shock, and other chemicals (Sax
1984, p. 2295)
Incompatibility (Materials to Avoid): Reacts vigorously with oxidizing
materials. Becomes shock-sensitive when mixed with chloropicrin (Sax
1984, p. 2295).
Hazardous Decomposition or Byproducts: Highly toxic fumes of bromine
containing compounds are formed when this material is heated to
decomposition (Sax 1984, p. 2295).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 106-96-7
Page 3 of 3
PROPARGYL BROMIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (Sax 1984, p. 2295)
Health Hazards (Acute, Delayed, and Chronic): This material is very
toxic via the oral route (Sax 1984, p. 2295). If inhaled, may be harmful;
contact may cause burns to skin and eyes (DOT 1984, Guide 29).
Signs and Symptoms of Exposure: Symptoms include skin irritation and
tearing of the eyes (-NFPA 1978).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Keep victim quiet and maintain normal body temperature (DOT
1984, Guide 29).
SECTION VI -- USE INFORMATION
This material is used as a soil fumigant (Hawley 1981, p. 861). Not
registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Shut off ignition sources; no flames, smoking or flames in hazard area.
Do not touch spilled material; stop leak if you can do it without risk.
Use water spray to reduce vapors, do not get water inside container. Take
up spills with sand or noncombustible absorbent material. For large
spills dike far ahead. Wear self-contained breathing apparatus (DOT 1984,
Guide 29).
-------
CAS Registry Number: 106-99-0
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- BUTADIENE
CAS Registry Number: 106-99-0
Synonyms: 1,3-Butadiene; Alpha, Gamma-Butadiene; Alpha-Butadiene;
Biethylene; Bivinyl; Buta-l,3-diene; Butadiene-l,3-Uninhibited; Divinyl;
Erythrene; NCI-C50602; Pyrrolylene; Vinylethylene
Chemical Formula: C.H,
4 6
Molecular Weight: 54.09
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 1000 ppm (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 1000 ppm (2200 tng/m3); STEL 1250 ppm (2750 mg/m3)
(*ACGIH 1984)
IDLH: 20,000 ppm (NIOSH/OSHA 1978, p. 52)
Other Limits Recommended: Maximum air concentration (USSR) 100 mg/m3
(Encyc Occupat Health and Safety 1983, p. 347). Industrial substance
suspected of carcinogenic potential for humans, recommended TLV 10 ppm
(ACGIH 1984, p. 41).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 24°F, -4.5°C (*Merck 1983)
Specific Gravity (H 0=1): 0.6211 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): 910 at 20°C (-ACGIH 1980)
Melting Point: -164°F, -109°C (*Weast 1979)
Vapor Density (AIR=1): 1.87 (»Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Weast 1979); 0.05% (NIOSH/OSHA 1978,
p. 52)
-------
CAS Registry Number: 106-99-0
Page 2 of 4
BUTADIENE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless gas (''-Merck 1983) or liquified
compressed gas (inhibited) ("CHRIS 1978) with a mild aromatic (*ACGIH
1980) or gasoline-like (--CHRIS 1978) odor.
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -105°F (method not given) (''•Sax 1979)
Flammable Limits:
LEL: 2.0% (*Patty 1963)
DEL: 11.5% ('-Patty 1963)
Extinguishing Methods: Let tank car, tank truck or storage tank burn
unless leak can be stopped; with smaller tanks or cylinders, extinguish/
isolate from other flammables. Small fires: dry chemical or carbon
dioxide. Large fires: water spray, fog, or foam. Move container from
fire area if you can do so without risk. Stay away from ends of tanks.
For massive fire in cargo area, use unmanned hose holder or monitor
nozzles; if this is impossible, withdraw from area and let fire burn.
Withdraw immediately in case of rising sound from venting safety device or
any discoloration of tank due to fire. Cool container with water using
unmanned device until well after fire is out (DOT 1984, Guide 17).
Special Fire Fighting Procedures: Shut off flow of gas. Use water to
keep fire-exposed containers cool and to protect men effecting the shut
off. In advanced or massive fires, firefighting should be done from a
protected location (*NFPA 1978). Apply water from as far a distance as
possible (Student 1981, p. 78). Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear self-contained
(positive pressure if available) breathing apparatus and full protective
clothing. Isolate for 1/2 mile in all directions if tank car or truck is
involved in fire (DOT 1984, Guide 17).
Unusual Fire and Explosion Hazards: Extremely flammable. May be
ignited by heat, sparks or flames. Vapors may travel to a source of
ignition and flash back. Container may explode violently in heat of
fire. Vapor explosion hazard indoors, outdoors or in sewers (DOT 1984,
Guide 17). Explosion hazard is high if the material is heated under
pressure, in air, or mixed with phenol, chlorine dioxide or crotonaldehyde.
It may form explosive peroxides upon exposure to air. It emits acrid
fumes when heated (''"Sax 1979). At elevated temperatures, polymerization
may take place and containers may rupture ("NFPA 1978). May travel a
considerable distance to a source of ignition and flash back. Butadiene
vapors are uninhibited and may form polymers in vents or flame arresters
of storage tanks, resulting in stoppage of vents (NFPA 1978, p. 49-22).
-------
CAS Registry Number: 106-99-0
Page 3 of 4
BUTADIENE
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (-CHRIS 1978)
Stable:
Conditions to Avoid: Heat (*Sax 1979), mixing with air (-Clayton
and Clayton 1981-82).
Incompatibility (Materials to Avoid): Air, phenol, chlorine dioxide,
and croto°naldehyde (-Sax 1979).
Hazardous Decomposition or Byproducts: May form explosive peroxides
upon exposure to air (*Sax 1979). Formaldehyde and acrolein are produced
when material is exposed to photooxidation with ozone and nitrogen
dioxide, as in smog formation ("Grant 1974).
Hazardous Polymerization: May Occur: Yes (*NFPA 1978)
May Not Occur:
Conditions to Avoid: Heat (-NFPA 1978). Elevated temperatures may
cause polymerization which can cause violent rupture of containers
(NFPA 1978, p. 49-22).
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Lefaux 1968)
Skin: Yes (Sax 1984, p. 545)
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Death can result 23
minutes after inhaling air containing 25% butadiene (*Lefaux 1968). It is
a central nervous system depressant in high concentrations. It may be
irritating to skin and mucous membranes ("Merck 1983) . Contact with the
liquid may cause frostbite. It can asphyxiate by the displacement of air
(Student 1981, p. 78). If inhaled, may be harmful; contact may cause
burns to skin and eyes. Vapors may cause dizziness or suffocation. Fire
may produce irritating or poisonous gases (DOT 1984, Guide 17).
1,3-Butadiene has suspected carcinogenic potential for humans (*ACGIH
1984).
Signs and Symptoms of Exposure: Initial signs and symptoms include
blurred vision, nausea, prickling and dryness of the mouth, throat, and
nose, followed by fatigue, headache, vertigo, decreased blood pressure and
pulse rate, unconsciousness, and respiratory paralysis (*Clayton and
Clayton 1981-82).
Medical Conditions Generally Aggravated by Exposure: Not Found
-------
CAS Registry Number: 106-99-0
Page 4 of 4
BUTADIENE
SECTION V -- HEALTH HAZARD DATA (Continued)
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of frostbite, thaw
frosted parts with water. Keep victim quiet and maintain normal body
temperature (DOT 1984, Guide 17).
SECTION VI -- USE INFORMATION
This material is used primarily as a monomer and comonomer for synthetic
rubbers and resins; it is also a chemical intermediate for several
compounds ("'SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Remove all ignition sources. Ventilate area. Stop flow of gas
(*NIOSH/OSHA 1981). Wear safety goggles, mask, apron, and rubber gloves
(•'•Lefaux 1968). Keep material out of water sources and sewers. Attempt
to stop leak if without hazard. Use water spray to knock down vapors.
Avoid breathing vapors. Keep upwind. Do not handle broken packages
without protective equipment. If fire becomes uncontrollable or container
is exposed to direct flame, evacuate for a radius of 2,500 feet. If
material is leaking (not on fire) downwind evacuation must be considered
(Student 1981, p. 78). Isolate area until gas has dispersed (DOT 1984,
Guide 17).
-------
CAS Registry Number: 107-02-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ACROLEIN
CAS Registry Number: 107-02-8
Synonyms: Acraldehyde; Acrylaldehyde; Acrylic Aldehyde; Allyl Aldehyde;
Aqualin; Aqualine; Ethylene Aldehyde; Magnacide H; NSC 8819; Propenal;
2-Propenal; Prop-2-en-l-al; 2-Propen-l-one
Chemical Formula: C0H.O
3 4
Molecular Weight: 56.06
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 0.1 ppm (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.1 ppm (0.25 mg/m3); STEL 0.3 ppm (0.8 rag/m3)
(*ACGIH 1983)
IDLH: 5 ppm (*Encyc Occupat Health and Safety 1983)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 126°F, 52.5°C (*Merck 1983)
Specific Gravity (H20=l): 0.8389 at 20°C; 0.8621 at 0°C (*Merck 1983)
Vapor Pressure (mmHg): 210 at 68°F, 20°C; 135.71 at 50°F, 10°C (*Weed
Science Society of America 1974)
Melting Point: -126°F, -88°C (*Merck 1983)
Vapor Density (AIR=1): 1.94 (*Encyc Occupat Health and Safety 1983)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in 2-3 parts water (*Merck 1983)
-------
CAS Registry Number: 107-02-8
Page 2 of 4
ACROLEIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless or yellowish liquid with extremely
sharp, disagreeable, acrid, irritating odor (*Sax 1979, *CHRIS 1980)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -15°F, -26°C (CC); less than 0°F, -18°C
(OC) (*NFPA 1978)
Flammable Limits:
LEL: 2.8% (*NFPA 1978)
DEL: 31% (*NFPA 1978)
Extinguishing Methods: Dry chemical, alcohol foam, or carbon dioxide.
Water may be ineffective, but can be used to keep containers cool (*NFPA
1978).
Special Fire Fighting Procedures: In advanced or massive fires, fire
fighting should be done from safe distance or from protected location.
Use dry chemical, alcohol foam, or carbon dioxide. Water may be
ineffective, but should be used to keep fire-exposed containers cool. If
a leak or spill has not ignited, use water spray to disperse vapors. If
it is necessary to stop a leak, use water spray to protect men attempting
to do so. Water spray may be used to flush spills away from exposures and
to dilute spills to nonflammable mixtures (*NFPA 1978). Withdraw
immediately in case of rising sound from venting safety device or any
discoloration of tank due to fire (DOT 1984, Guide 30).
Unusual Fire and Explosion Hazards: Under fire conditions,
polymerization may occur. If inside a container, violent rupture of the
container may take place (*NFPA 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Merck 1983)
Stable:
Conditions to Avoid: Exposure to alkalis or strong acids (*Encyc
Occupat Safety and Health 1983) or to oxygen (*NFPA 1978).
Incompatibility (Materials to Avoid): Alkaline or strong acids act as
catalysts, causing a condensation reaction and liberating energy.
Reaction may be very rapid and violent (*Encyc Occupat Health and Safety
1983). Readily converted by oxygen to hazardous peroxides and acids
(*NFPA 1978).
-------
CAS Registry Number: 107-02-8
Page 3 of 4
ACROLEIN
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes (*Sax 1975).
Hazardous Polymerization: May Occur: Yes (*NFPA 1978)
May Not Occur:
Conditions to Avoid: Elevated temperatures, such as fire
conditions. (Polymerization inside container could cause violent
rupture of container under fire conditions.) (*NFPA 1978)
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-NIOSH/RTECS 1985)
Skin: Yes (*NIOSH/RTECS 1985)
Ingestion: Yes (-Gosselin 1984)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic;
probable oral human lethal dose is 5-50 mg/kg, between 7 drops and one
teaspoon for a 70 kg (150 Ib.) person (*Gpsselin 1984). Inhalation of air
containing 10 ppm of acrolein may be fatal in a few minutes (*NRC 1981).
Death from cardiac failure accompanied by hyperemia and hemorrhage of the
lungs and degeneration of the bronchial epithelium is possible. Acrolein
causes acute respiratory and eye irritation; severe gastrointestinal
distress with slowly developing pulmonary edema (lungs fill up with
fluid); and skin irritation (Gosselin 1984, p. 11-186).
Signs and Symptoms of Exposure: If swallowed, produces acute abdominal
pains. Acrolein's irritant properties cause skin blisters and burns,
intense tearing, and nasal irritation. If lung edema develops, patient
experiences difficulty in breathing, coughing, and fatigue (Gosselin 1984,
p. 11-186).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing give artificial respiration. If
breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes
(DOT 1984, Guide 30). Terminate exposure immediately. Patient should
take deep breaths. Complete rest should be enforced for 24-48 hours
whether toxic symptoms are recognized or not (Gosselin 1976, pp. 257-8).
-------
CAS Registry Number: 107-02-8
Page 4 of 4
ACROLEIN
SECTION VI -- USE INFORMATION
Acrolein is used in manufacture of colloidal forms of metals; making
plastics, perfumes; as a warning agent in methyl chloride refrigerant; and
has been used in military poison gas mixtures (*Merck 1983). It is also
used as an intermediate in the production of glycerine, methionine,
acrylic acid, and esters (*SRI). Acrolein is also an intermediate for
glycerol, polyurethane, polyester resins, and Pharmaceuticals (*Hawley
1981). Additionally, acrolein is used as an aquatic herbicide, biocide,
slimicide ("Farm Chemicals Handbook 1984) and molluscicide (*Kearney and
Kaufman 1975).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
When handling acrolein, full protective clothing including self-contained
breathing apparatus, rubber gloves, boots, and band around legs, arms, and
waist should be worn. No skin surface should be exposed (*NFPA 1978).
Remove all ignition sources. Ventilate area of spill or leak. For large
quantities, cover with sodium bisulfite, add small amount of water and
mix. Then, after 1 hour, flush with large amounts of water and wash site
with soap solution. Liquid should not be allowed to enter confined space,
such as sewer, because of possibility of explosion. Take up spills for
disposal by absorbing it in vermiculite, dry sand, or earth and disposing
in a secured landfill or combustion chamber (*NIOSH 1981).
-------
CAS Registry Number: 107-07-3
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CHLOROETHANOL
CAS Registry Number: 107-07-3
Synonyms: 2-Chloroethanol; 2-Chloro-l-ethanol; 2-Chloroethyl Alcohol;
2-Hydroxyethyl Chloride; 2-Monochloroethanol; beta-Chloroethanol;
beta-Chloroethyl Alcohol; beta-Hydroxyethyl Chloride; delta-Chloroethanol;
Ethanol, 2-Chloro-; Ethene, Chlorohydrin; Ethylchlorohydrin; Ethylene
Chlorhydrin; Ethylene Glycol, Chlorohydrin; Glycol Chlorohydrin; Glycol
Monochlorohydrin; Glycomonochlorhydrin; NCI-C50135
Chemical Formula: C H CIO
Molecular Weight: 80.52
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 5 ppm (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: Ceiling 3 mg/m3 (skin) (-ACGIH 1983)
IDLH: 10 ppm (*Encyc Occupat Health and Safety 1983)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 262°F, 128°C (*Weast 1979)
Specific Gravity (H 0=1): 1.197 (*Merck 1983)
Vapor Pressure (mmHg): 4.9 (''-Clayton and Clayton 1981-82)
Melting Point: -89.5°F, -67.5°C (*Weast 1979)
Vapor Density (AIR=1): 2.78 (--Patty 1963)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Freely soluble (*Weast 1979)
-------
CAS Registry Number: 107-07-3
Page 2 of 4
CHLOROETHANOL
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless, glycerine-like liquid (^Browning
1965); faint ethereal odor (»Sax 1979); sweet, pleasant odor (*CHRIS 1978)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 105°F (OC) (*Merck 1983); 140°F, 60°C (CC)
(*NFPA 1978)
Flammable Limits:
LEL: 4.9% (*NFPA 1978)
UEL: 15.9% (*NFPA 1978)
Extinguishing Methods: Water spray may be used to extinguish the fire
because the material can be cooled below its flash point (*NFPA 1978).
Alcohol foam, carbon dioxide, and dry chemical may be used ("CHRIS 1978).
Special Fire Fighting Procedures: Do not breathe fumes from burning
material. Air purifying respirator or self-contained breathing apparatus,
coat, pants, gloves, and boots should be worn. No skin surface should be
exposed. Bands around legs, arm and waist should be provided (*NFPA 1978),
Unusual Fire and Explosion Hazards: Its decomposition products will
react with water or steam to produce toxic and corrosive fumes ('vSax
1979). Vapors are heavier than air and may flash back to a source of
ignition (*CHRIS 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits highly toxic fumes of phosgene (*Sax 1979). Hydrogen chloride fumes
may be formed (-CHRIS 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 107-07-3
Page 3 of 4
CHLOROETHANOL
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Encyc Occupat Health and Safety
1983)
Skin: Yes ("Encyc Occupat Health and Safety 1983)
Ingestion: Yes (*Encyc Occupat Health and Safety
1983)
Health Hazards (Acute, Delayed, and Chronic): Very toxic; probable
oral lethal dose in humans is 50-500 mg/kg or between 1 teaspoon and 1
ounce for a 70 kg (150 Ib.) person (*Gosselin 1976). Poisoning causes
liver and kidney degeneration and irritates mucous membranes; it may be
cumulative (*Merck 1983). Several fatal cases with brain edema and lung
edema have been reported from industrial exposure by inhalation and skin
contact (*Encyc Occupat Health and Safety 1983). It is more toxic by skin
contact than orally (-Merck 1983).
Signs and Symptoms of Exposure: It may cause nausea, vomiting, pains
in head and chest, and stupefaction ("Merck 1983). It can induce
dizziness, visual disturbances, weakness, irregular breathing, shock,
bluing of skin and coma (*Encyc Occupat Health and Safety 1983).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give oxygen and establish
respiration. In case of contact, immediately flush skin or eyes with
running water for at least 15 minutes. Speed in removing from skin is of
extreme importance. Remove and isolate contaminated clothing and shoes at
site. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Manufacture of insecticides; treating sweet potatoes before planting
(*Merck 1983); introduction of hydroxyethyl group in organic synthesis;
used as a solvent (*Hawley 1981); employed in separating butadiene from
hydrocarbon mixtures (*Clayton and Clayton 1981-82); intermediate for
indigo and thiodiethylene glycol (*SRI); used for removal of tar spots;
and cleaning agent for machines ("Browning 1965)
-------
CAS Registry Number: 107-07-3
Page 4 of 4
CHLOROETHANOL
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Remove all ignition sources. Ventilate area of spill or leak. For small
quantities, absorb on paper towels. Evaporate in a safe place (such as a
fume hood). Allow sufficient time for evaporating vapors to completely
clear the hood ductwork. Burn the paper in a suitable location away from
combustible materials. Large quantities can be collected and atomized in
a suitable combustion chamber equipped with an appropriate effluent gas
cleaning device. It should not be allowed to enter a confined space, such
as a sewer, because of the possibility of an explosion. Absorb it in
vermiculite, dry sand, earth or a similar material and dispose in a
secured sanitary landfill ("NIOSH/OSHA 1981). Do not touch material.
Rubber gloves offer little protection, since dangerous amounts may rapidly
penetrate through rubber. Wear self-contained breathing apparatus and do
not expose skin ("CHRIS 1978; -Clayton and Clayton 1981-82).
-------
CAS Registry Number: 107-11-9
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ALLYLAMINE
CAS Registry Number: 107-11-9
Synonyms: 2-Propen-l-amine; 2-Propenylamine; 3-Amino-l-Propene;
3-Aminopropene; 3-Aminopropylene; Monoallylamine
Chemical Formula: CRN
Molecular Weight: 57.09
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC,... inhalation
(rat) 0.66 mg/liter/4 hours; LD dermal (rabbit) 35 mg/kg (*NIOSH/RTECS
1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 131-136°F, 55-58°C (*Merck 1976)
Specific Gravity (H20=l): 0.76 at 20°C/20°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): 2.0 (*NFPA 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (*Merck 1976)
Appearance and Odor: A colorless to light yellow liquid (*NFPA 1984),
strong ammonia odor (*Merck 1976).
-------
CAS Registry Number: 107-11-9
Page 2 of 3
ALLYLAMINE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -20°F (CC) (*NFPA 1978)
Flammable Limits:
LEL: 2.2% (*NFPA 1978)
UEL: 22% (*NFPA 1978)
Extinguishing Methods: Wear self-contained breathing apparatus and
full protective clothing (*NFPA 1978). Use dry chemical, alcohol foam, or
carbon dioxide. Water may be used to keep exposed containers cool (*NFPA
1978). Dike fire control water for later disposal. Withdraw immediately
in case of rising sound from venting safety device or discoloration of
tank due to fire ("DOT 1984).
Special Fire Fighting Procedures: Keep unnecessary people away and
isolate hazard area. Stay upwind and keep away from low areas. Isolate
for 1/2 mile in all directions if tank car or truck is involved ('"'DOT
1984).
Unusual Fire and Explosion Hazards: Flammable when exposed to heat,
sparks, or flame ("Sax 1975). Vapor forms explosive mixtures with air
over a wide range. Use caution when approaching fire and applying water
("NFPA 1978). Vapor explosion and poison hazard indoors, outdoors or in
sewers. Runoff to sewer may create fire or explosion hazard ("DOT 1984).
Can react with oxidizing materials. When heated to decomposition, it
emits toxic fumes (*Sax 1975).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Avoid heating to decomposition (*Sax 1978).
May become unstable at elevated temperatures and pressures or may
react with water with non-violent release of energy (*NFPA 1978).
Incompatibility (Materials to Avoid): Oxidizing materials (*Sax 1975).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes (*Sax 1975).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 107-11-9
Page 3 of 3
ALLYLAMINE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*NFPA 1978)
Skin: Yes (*NFPA 1978)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): Acute: an eye, skin,
and respiratory tract irritant (*NFPA 1978) which is highly toxic if
inhaled or ingested and moderately toxic if absorbed on skin. Ingestion
or inhalation may cause death or permanent injury after very short
exposure to small quantities. Skin absorption may cause irreversible and
reversible changes (*Sax 1975). Toxic air concentration (TClo) in humans
is 5 ppm over 5 minutes (*NIOSH/RTECS 1985). Vapors are extremely
unpleasant and may ensure voluntary avoidance of dangerous concentrations
(-Grant 1974). Will irritate nose and throat at 2.5 ppm (-Patty 1963).
Signs and Symptoms of Exposure: Symptoms include irritation of nose,
eyes, and mouth with tearing, runny nose, and sneezing ("Patty 1963). Can
cause excitement, convulsions, and death (*Merck 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. Remove and isolate contaminated clothing and
shoes at site. In case of contact, flush skin or eyes with water for 15
minutes. Keep victim quiet and maintain normal body temperature. Keep
victim under careful watch since effects may be delayed (DOT 1984, Guide
28).
SECTION VI -- USE INFORMATION
Used as a chemical intermediate for mercurial diuretics ("SRI), as a
pharmaceutical intermediate and in organic synthesis (*Hawley 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
For leaks or spills, use water spray to disperse vapors and protect men
attempting to stop leak. Water spray may be used to flush spills away
from exposures and to dilute spills to nonflammable mixtures (*NFPA
1978). Shut off ignition sources and keep away all flames, smoking, or
flares. Do not touch spilled material. Take up small spills with sand or
other noncombustible absorbent material and place in containers for later
disposal. For large spills, dike far ahead for later disposal (*DOT
1984). Local exhaust or general ventilation methods should be used in
enclosed spaces (*Sax 1975). Do not breathe vapors. Wear proper
respiratory protection, protective clothing, and eye protection (See
Section V above).
-------
CAS Registry Number: 107-12-0
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PROPIONITRILE
CAS Registry Number: 107-12-0
Synonyms: Cyanoethane; Ether Cyanatus; Ethyl Cyanide; Hydrocyanic Ether;
Propanenitrile; Propionic Nitrile; Propiononitrile; Propylnitrile
Chemical Formula: C H N
Molecular Weight: 55.08
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 5 mg (CN)/m3 (skin) (-ACGIH 1983)
IDLH: Not Found
Other Limits Recommended: Occupational exposure to nitriles
recommended standard, air: TWA 14 mg/m3 (*NIOSH/RTECS 1985). Maximum
allowable concentration (USSR) 0.3 mg/m3 (as HCN) (Encyc Occupat Health
and Safety 1983, p. 1445). Toxicity information: LC.. inhalation
(rat) 1.12 mg/liter/4 hours; LC,.ft inhalation (mouse) 0.37 mg/liter/hour
(*NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 207°F, 97.2°C (-Merck 1983)
Specific Gravity (H 0=1): 0.8020 at 0°C/4°C (-Merck 1983)
Vapor Pressure (mmHg): 40 at 22°C (*Clayton and Clayton 1981-82)
Melting Point: -133°F, -91.8°C (*Merck 1983)
Vapor Density (AIR=1): 1.9 (-Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 11.9 g/100 ml at 40°C (*Merck 1983)
-------
CAS Registry Number: 107-12-0
Page 2 of 4
PROPIONITRILE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless (''"Clayton and Clayton 1981-82) liquid
(Hawley 1981, p. 1428); pleasant, ethereal, sweetish odor ("Merck 1983)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 2°C (CC) (*Bretherick 1979)
Flammable Limits:
LEL: 3.1% (*Bretherick 1979)
UEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray, and foam. Large fires: water spray, fog, or foam. Move
containers from fire area if you can do it without risk. Dike fire
control water for later disposal; do not scatter the material. Cool
containers that are exposed to flames with water from the side until well
after fire is out. Withdraw immediately in case of rising sound from
venting safety device or any discoloration of tank due to fire (DOT 1984,
Guide 28).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Wear positive pressure breathing apparatus and special protective
clothing. Isolate for 1/2 mile in all directions if tank car or truck is
involved in fire (DOT 1984, Guide 28).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of nitrogen oxides and cyanide (Sax 1984, p. 2300). It
is a flammable/combustible material and may be ignited by heat, sparks or
flames. Vapors may travel to a source of ignition and flash back.
Container may explode in heat of fire. Vapor explosion and poison hazard
indoors, outdoors or in sewers. Runoff to sewer may create fire or
explosion hazard (DOT 1984, Guide 28).
I
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: May become unstable at elevated temperatures
and pressures (*NFPA 1978).
Incompatibility (Materials to Avoid): Generates cyanide ions (*Peer
Review Committee). Poisonous on contact with acids ("Merck 1983).
-------
CAS Registry Number: 107-12-0
Page 3 of 4
PROPIONITRILE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: Poisonous when heated to
decomposition (*Merck 1983). When heated to decomposition, it emits toxic
fumes of nitrogen oxides and cyanides (Sax 1984, p. 2300).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Deichman 1969)
Skin: Yes (*Deichman 1969)
Ingestion: Yes (Sax 1984, p. 2300)
Health Hazards (Acute, Delayed, and Chronic): It is highly toxic
("Encyc Occupat Health and Safety 1981) . This super toxic compound has a
probable oral lethal dose in humans of less than 5 mg/kg or a taste (less
than 7 drops) for a 70 kg (150 Ib.) person (*Gosselin 1976). It is a mild
to moderate skin and eye irritant (Weiss 1980, p. 1145).
Signs and Symptoms of Exposure: Can cause death (*NFPA 1978).
Exposure results in headache, dizziness, rapid pulse, deep-rapid
breathing, nausea, vomiting, unconsciousness, convulsions and sometimes
death ("Rumack 1975 to Present). Chronic exposure over long periods may
cause fatigue and weakness (*Merck 1968). Can cause same general symptoms
as hydrogen cyanide but onset of symptoms is likely to be slower (*Clayton
and Clayton 1981-82). Contact may cause burns to skin and eyes (DOT 1984,
Guide 28).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes
(DOT 1984, Guide 28).
-------
CAS Registry Number: 107-12-0
Page 4 of 4
PROPIONITRILE
SECTION VI -- USE INFORMATION
It is used as a setting agent for resins; a raw material for some
medicines ("Rumack 1975 to Present) and a chemical intermediate for
di-n-propylamine ("SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors and skin contact (see Section V above). Shut off
ignition sources; no flares, smoking or flames in hazard area. Do not
touch spilled material; stop leak if you can do it without risk. Use
water spray to reduce vapors. Small spills: take up with sand or other
noncombustible absorbent material and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 28).
-------
CAS Registry Number: 107-13-1
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ACRYLONITRILE
CAS Registry Number: 107-13-1
Synonyms: 2-Propenenitrile; Acrylon; Acrylonitrile Monomer; Cyanoethylene;
ENT 54; Fumigrain; Miller's Fumigrain; NCI-C50215; Propenenitrile; TL 314;
VCN; Vinyl Cyanide
Chemical Formula: C H N
Molecular Weight: 53.60
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 2 pprn; 10 ppm/15 minutes (*NIOSH/RTECS 1985)
ACGIH TLV: Recognized carcinogenic or cocarcinogenic potential, with
assigned TLV of 2 ppm (skin)(*ACGIH 1983)
IDLH: 500 ppm (NIOSH/OSHA Joint Standards Completion Project, 1975)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 171°F, 77.3°C (*Merck 1983)
{2
Specific Gravity (H 0=1): 0.8004 at 25°C/4°C (-Merck 1983)
Vapor Pressure (mmHg): 100 at 23°C (*IARC 1972-1985)
Melting Point: -116°F, -82.0°C ('-Sax 1979)
Vapor Density (AIR=1): 1.9 (-Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 7.35 parts dissolve in 100 parts water at 20°C
(*Merck 1983)
-------
CAS Registry Number: 107-13-1
Page 2 of 4
ACRYLONITRILE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Clear, colorless liquid (some technical grades
slightly yellow) with a very slight odor of peach pits ("Clayton and
Clayton 1981-82; '-Lefaux 1968)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 32°F, 0°C (*Merck 1983)
Flammable Limits:
LEL: 3% (*NFPA 1978)
DEL: 17% (*NFPA 1978)
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray or foam. Large fires: water spray, fog or foam. Stay away
from ends of tanks. Do not get water inside container. Cool containers
that are exposed to flames with water from the side until well after fire
is out. For massive fire in cargo area, use unmanned hose holder or
monitor nozzles; if this is impossible, withdraw from area and let fire
burn. Withdraw immediately in case of rising sound from venting safety
device or any discoloration of tank due to fire (''"DOT 1984).
Special Fire Fighting Procedures: In advanced or massive fires, fire
fighting should be done from a safe distance or a protected location
(*NFPA 1978). Isolate for 1/2 mile in all directions if tank car or truck
is involved in fire (*DOT 1984).
Unusual Fire and Explosion Hazards: Materials are too dangerous to
health to expose fire fighters. A few whiffs of vapor could cause death
or vapor or liquid could be fatal on penetrating the fire fighter's normal
full protective clothing. The normal full protective clothing and
breathing apparatus available to the average fire department will not
provide adequate protection against inhalation or skin contact with these
materials (*NFPA 1978). Explosion hazard is moderate. It is flammable
and explosive at normal room temperatures (*Encyc Occupat Health and
Safety 1971). Can react violently with strong acids, amines, strong
alkalis (*Sax 1979). Vapors may travel considerable distance to source of
ignition and flash back. Dilute solutions are also hazardous (flash point
of a solution of 2 percent in water is 70°F) (*NFPA 1978).
-------
CAS Registry Number: 107-13-1
Page 3 of 4
ACRYLONITRILE
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (-Clayton and Clayton 1981-82)
Stable:
Conditions to Avoid: Moderate hazard is possible when it is
exposed to flames, strong acids, amines and alkalis (*Sax 1979).
Incompatibility (Materials to Avoid): Avoid strong acids, amines,
alkalis (*Sax 1979). Also, incompatible with strong oxidizers (especially
bromine) copper and copper alloys (NIOSH/OSHA 1978, p. 42).
Hazardous Decomposition or Byproducts: When heated or burned, toxic
hydrogen cyanide gas and oxides of nitrogen are formed ('"'CHRIS 1978).
Hazardous Polymerization: May Occur: Yes (*NFPA 1978)
May Not Occur:
Conditions to Avoid: May polymerize spontaneously in the
container, particularly in absence of oxygen or on exposure to visible
light (*Merck 1983). If polymerization occurs in containers, there is
a possibility of violent rupture (-NFPA 1978).
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes ("DOT 1984)
Skin: Yes (-DOT 1984)
Ingestion: Yes (-DOT 1984)
Health Hazards (Acute, Delayed, and Chronic): It is classified as very
toxic. Probable oral lethal dose for human is 50-500 mg/kg (between 1
teaspoon and 1 oz.) for a 70 kg (150 Ib.) person. Irritant skin dose --
500 mg. Toxic concentrations have been reported at 16 ppm/20 rain.
(*Gosselin 1976). Acute toxicity is similar to that due to cyanide
poisoning and the level of cyanide ion in blood is related to the level of
poisoning ("Clayton and Clayton 1981-82). Inhalation or ingestion results
in collapse and death due to tissue anoxia (lack of oxygen) and cardiac
arrest (heart failure) (-Encyc Occupat Health and Safety 1983).
Signs and Symptoms of Exposure: Acrylonitrile reaction causes redness,
blisters and some systemic signs ("Gosselin 1976). Symptoms derive from
tissue anoxia in order of onset: limb weakness, dyspnea (difficult
breathing), burning sensation in throat, dizziness, impaired judgment,
cyanosis (turning blue), nausea, collapse, irregular breathing,
convulsions and death. In later stages collapse, irregular breathing or
convulsions and cardiac arrest may occur without warning. Some patients
appear hysterical or may even be violent (*Encyc Occupat Health and Safety
1983).
-------
CAS Registry Number: 107-13-1
Page 4 of 4
ACRYLONITRILE
SECTION V -- HEALTH HAZARD DATA (Continued)
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Get emergency medical treatment
immediately. If victim has taken the substance by ingestion (orally) and
is not showing symptoms, give syrup of ipecac with salt solution or
water. If there is exposure through skin contact, wash twice with soap
and water. Exposed eyes should be flushed copiously with water for at
least 15ominutes. If the victim stops breathing before emergency medical
treatment is available, give artificial respiration or oxygen but avoid
mouth to mouth resuscitation; also avoid contact with contaminated skin
(Gosselin 1984, p. III-127; *Rumack 1985).
SECTION VI -- USE INFORMATION
Used primarily in plastics manufacturing as a copolymer and comonomer
(*SRI); to improve dye and working properties of acrylic fibers (*Hamilton
1974); formerly used as a fumigant for food commodities (*Farm Chemicals
Handbook 1983).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Wear proper respiratory protection, impervious protective clothing and
proper eye protection (see Section V above). Shut off ignition sources;
no flares, smoking or flames in hazard area. Do not touch material; stop
leak if you can do so without risk. Use water spray to reduce vapors; do
not get water inside container. Small spills: flush area with flooding
amounts of water. Large spills: dike far ahead of spill for later
disposal (*DOT 1984). If leak or spill has not ignited, use water spray
to disperse vapors (*NFPA 1978). In case of a spill or leak from a drum
or smaller container or a small leak from a tank, isolate for 90 feet in
all directions. In case of a large spill from a tank or from many
containers, first isolate for 180 feet in all directions, then evacuate in
a downwind direction an area 0.4 miles long and 0.6 miles wide (DOT 1984,
Table of Isolation and Evacuation Distances).
-------
CAS Registry Number: 107-15-3
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ETHYLENEDIAMINE
CAS Registry Number: 107-15-3
Synonyms: 1,2-Diaminoethane; 1,2-Ethanediamine; 1,2-Ethylenediamine; beta-
Aminoethylamine; Dimethylenediamine; Ethylendiamine
Chemical Formula: C.H0N.
L o i.
Molecular Weight: 60.12
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 10 ppm (25 mg/m3) (-NIOSH/OSHA 1978)
ACGIH TLV: TWA 10 ppm (25 mg/m3) (-ACGIH 1983)
IDLH: 2000 ppm (*NIOSH/OSHA 1978)
Other Limits Recommended: Maximum allowable concentration (USSR):
2 mg/m3 (Encyc Occupat Health and Safety 1983, p. 141)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 241°F, 116°C (*Merck 1983)
Specific Gravity (H 0=1): 0.898 at 25°C/4°C (-Merck 1983)
Vapor Pressure (mmHg): 10.7 at 20°C (*Hawley 1981)
Melting Point: 46°F, 8°C (*Merck 1983)
Vapor Density (AIR=1): 2.07 (*Sax 1975)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very soluble in water (*Weast 1979)
Appearance and Odor: Colorless, thick liquid ("Sax 1975); ammonia-like
odor ("Encyc Occupat Health and Safety 1983)
-------
CAS Registry Number: 107-15-3
Page 2 of 4
ETHYLENEDIAMINE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 93°F, 34°C (CC); 150°F, 66°C (OC) (*NFPA
1978)
Flammable Limits:
LEL: 4.2% (*NFPA 1978)
UEL: 14.4% (*NFPA 1978)
Extinguishing Methods: Use water spray, dry chemical, alcohol foam, or
carbon dioxide (-NFPA 1978).
Special Fire Fighting Procedures: Wear full protective clothing
including gloves and boots. If necessary to enter closed area, wear
full-faced gas masks with self-contained breathing apparatus. Do not use
water in case of drum or tank fires (*CHRIS 1978). If a leak or spill has
not ignited, use water spray to reduce the vapors and dilute spills to
nonflammable mixtures. Use water to keep fire-exposed containers cool
(*NFPA 1978).
Unusual Fire and Explosion Hazards: Burning rate: 2.2 mm/minute
(-CHRIS 1978). When exposed to heat or flame, the material has a moderate
fire potential. The material can react readily with oxidizing materials
(*Sax 1975). Containers may explode in heat of fire (*DOT 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Carbon disulfide (*NRC 1981);
silver perchlorate (*NFPA 1978); imines (*Leleu MJ. 1979. CAH Notes Doc.
94:127-132); oxidizing materials (*Sax 1975).
Hazardous Decomposition or Byproducts: Material emits nitrogen oxides
when burned (*Rumack 1975 to Present).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 430)
Conditions to Avoid: Not Found
-------
CAS Registry Number: 107-15-3
Page 3 of 4
ETHYLENEDIAMINE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Arena 1979)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (-Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Vapor inhalations at a
concentration of 200 ppm for 5 to 10 minutes will lead to nasal irritation
and produce a tingling sensation. Inhalation at concentrations of 400 ppm
or greater leads to severe nasal irritation (^Clayton and Clayton
1981-82). Respiratory irritation may result (Gosselin 1984, p. 11-206).
Many individuals are hypersensitive to ethylenediamine exposure;
therefore, safe threshold limits are difficult to set (*ACGIH 1980).
Signs and Symptoms of Exposure: For inhalation, wheezing, heaviness in
the chest, and severe asthma may result. Ingestion will cause burns of
the mouth, esophagus, and stomach. Eye contact will cause serious burns.
Short single exposure to skin is likely to produce a skin burn, and
prolonged or repeated exposure will cause serious skin burns (*Rumack 1975
to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. Remove and isolate contaminated clothing at the site. In case of
contact with the material, immediately flush skin or eyes for 15 minutes
with running water. Keep victim quiet and maintain body temperature ("DOT
1984). For oral ingestion, immediately dilute with milk or water ("Rumack
1975 to Present).
SECTION VI -- USE INFORMATION
A solvent for casein, albumin, shellac, and sulfur; an emulsifier;
stabilizer for rubber latex; inhibitor in antifreeze solutions;
pharmaceutic aid (*Merck 1983); intermediate in synthesis of carbamate
fungicides and chelating agents (*SRI). An algacide and fungicide
(USEPA/Pesticide Index 1985).
-------
CAS Registry Number: 107-15-3
Page 4 of 4
ETHYLENEDIAMINE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Shut off ignition sources. Stop leak if possible without risk. Do not
touch spilled material. Use water spray to reduce vapors. Do not get
water inside containers. For small spills, absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. For large spills, dike far ahead of spill for later disposal.
Keep unnecessary people away and isolate area. Stay upwind and keep out
of low areas. Wear self-contained positive-pressure breathing apparatus
and full protective clothing. Isolate area for 1/2 mile in all directions
if tank car or truck is involved in fire (*DOT 1984).
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CAS Registry Number: 107-16-4
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- FORMALDEHYDE CYANOHYDRIN
CAS Registry Number: 107-16-4
Synonyms: Acetonitrile, Hydroxy-; 2-Hydroxyacetonitrile; alpha-
Hydroxyacetonitrile; alpha-Hydroxymethylcyanide; Cyanomethanol; Glycolic
Nitrile; Glyconitrile; Hydroxyacetonitrile; Hydroxymethylnitrile; Methylene
Cyanohydrin; USAF A-8565
Chemical Formula: C H NO
Molecular Weight: 57.06
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Recommended NIOSH standard air ceiling
concentration is 5 mg/m3/15 minutes (*NIOSH/RTECS 1985). Toxicity
information: LC, inhalation (rat) 0.58 mg/liter for 4 hours
low
(*NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 361°F, 183°C, with slight decomposition (*Weast 1979)
Specific Gravity (H20=l): Not Found
Vapor Pressure (mmHg): 1 at 63°C (*Patty 1963)
Melting Point: Less than -98°F, less than -72°C (*Weast 1979)
Vapor Density (AIR=1): 1.96 (*Patty 1963)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (*Patty 1963)
-------
CAS Registry Number: 107-16-4
Page 2 of 3
FORMALDEHYDE CYANOHYDRIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless oil ("Sax 1979); odorless (*Encyc
Occupat Health and Safety 1971); sweetish taste (-Patty 1963)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Acetonitrile) Do not
extinguish fire if material is leaking and flow cannot be stopped. Use
water in flooding quantities as fog. Use alcohol foam, carbon dioxide, or
dry chemical (Student 1981, pp. 3-4).
Special Fire Fighting Procedures: (Non-Specific -- Acetonitrile) Cool
containers with flooding quantities of water. Apply water from as far
away as possible. Avoid breathing vapors. Keep upwind. Wear
self-contained breathing apparatus. Avoid bodily contact with the
material. Wear boots, protective gloves, and goggles (Student 1981, pp.
3-4).
Unusual Fire and Explosion Hazards: Moderate explosion hazard when
exposed to heat or by spontaneous chemical reaction in the presence of
alkalies if uninhibited ("Sax 1979). When heated to decomposition, it
emits toxic fumes of cyanide and nitrogen oxides (Sax 1984, p. 1556).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Bretherick 1979)
Stable:
Conditions to Avoid: May explode on standing (*Bretherick 1979).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic cyanide and nitrogen oxide fumes (Sax 1984, p. 1556)
Hazardous Polymerization: May Occur: Yes (*Sax 1979)
May Not Occur:
Conditions to Avoid: Presence of alkalies, and exposure to heat
(*Sax 1979)
-------
CAS Registry Number: 107-16-4
Page 3 of 3
FORMALDEHYDE CYANOHYDRIN
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Rumack 1975 to Present)
Skin: Yes (*Hawley 1977)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic (*Patty
1963); exposure by any route should be avoided; may have fatal
consequences; death from asphyxiation may occur similar to that resulting
from hydrogen cyanide (*Encyc Occupat Health and Safety 1971).
Signs and Symptoms of Exposure: Similar to cyanide poisoning. Odor of
bitter almonds on patient's breath may or may not be present. Vomiting,
palpitations, confusion, anxiety, and vertigo may follow exposure.
Respiration may initially be rapid, then slow and labored, followed by
coma and convulsions (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Acetonitrile)
Move victim to fresh air; call emergency medical care. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen.
Remove and isolate contaminated clothing and shoes at the site. In case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Keep victim quiet and maintain normal body
temperature. Effects may be delayed; keep victim under observation (DOT
1984, Guide 28).
SECTION VI -- USE INFORMATION
This material is used in the manufacture of intermediates in pharmaceutical
production and as a component of synthetic resins (*Encyc of Occupat
Health and Safety 1971), as a chemical intermediate for organic compounds,
and as a solvent (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Acetonitrile) Build dikes to contain flow as necessary.
Use water spray to disperse vapors and dilute standing pools of liquid.
Avoid breathing vapors. Keep upwind. Wear self-contained breathing
apparatus. Avoid bodily contact with the material. Wear boots,
protective gloves, and goggles (Student 1981, pp. 3-4).
-------
CAS Registry Number: 107-18-6
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ALLYL ALCOHOL
CAS Registry Number: 107-18-6
Synonyms:- (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 308) AA; Allyl Al;
Allylic Alcohol; 2-Propen-l-ol; Vinylcarbinol; Propenyl Alcohol;
l-Propene-3-ol; 3-Hydroxypropene; Orvinylcarbinol; Propenol; Propen-l-ol-3;
2-Vinylcarbinol; 2-Propenyl Alcohol; Shell Unkrautted A; Weed Drench
Chemical Formula: C0H,0
J O
Molecular Weight: 58.09
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 2 ppm (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 2 ppm; STEL 4 ppm (skin) (*ACGIH 1983)
IDLH: 150 ppm (NIOSH/OSHA 1978, p.44)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 206°F, 97°C (*Merck 1976)
Specific Gravity (H20=l): 0.854 at 20°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 23.8 at 25°C (^Sunshine 1969)
Melting Point: -200°F, -129°C; freezes at -50°C (Weast 1980, p. C-466)
Vapor Density (AIR=1): 2.0 (*Patty 1963)
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 107-18-6
Page 2 of 4
ALLYL ALCOHOL
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Soluble (*Weast 1979)
Appearance and Odor: Mobile, colorless liquid with a pungent mustard
odor (*Merck 1976, *Martin 1974). Forms a glass at -190°C (-Worthing
1979).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 22°C (CC), 32°C (OC) (*Patty 1963)
Flammable Limits:
LEL: 2.5% (*Sunshine 1969)
DEL: 18% (*Sunshine 1969)
Extinguishing Methods: Extinguish with dry chemical, alcohol foam, or
carbon dioxide (*NFPA 1978). Dike fire control water for later disposal
and do not scatter the material (DOT 1984, Guide 28).
Special Fire Fighting Procedures: Water may be ineffective on fire.
Cool exposed containers with water. Wear goggles, self-contained
breathing apparatus, rubber overclothing, gloves (Weiss 1980, p. 63).
Unusual Fire and Explosion Hazards: Allyl alcohol vapor may explode if
ignited in confined areas. Combustion products may be poisonous. The
vapor is heavier than air and flashback along vapor trail may occur (Weiss
1980, p. 63). Gives off toxic fumes when heated (*NFPA 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): May react vigorously with
oxidizing materials, carbon tetrachloride, acids, oleum, sodium hydroxide,
diallyl phosphite, potassium chloride, or tri-n-bromomelamine (Sax 1984,
p. 159).
Hazardous Decomposition or Byproducts: Gives off toxic fumes when
heated (*NFPA 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 107-18-6
Page 3 of 4
ALLYL ALCOHOL
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Weiss 1980, p. 63)
Skin: Yes (Weiss 1980, p. 63)
Ingestion: Yes (Weiss 1980, p. 63)
Health Hazards (Acute, Delayed, and Chronic): Allyl alcohol is an
intense irritant to skin, eyes, nose, and throat (Weiss 1980, p. 63). It
causes burns on contact, and may cause pulmonary edema if inhaled. It is
poisonous in small quantities. The probable oral lethal dose is 50-500
rog/kg, or between 1 teaspoonful and 1 ounce for a 150-lb. person (Gosselin
1984, p. 11-98).
Signs and Symptoms of Exposure: Allyl alcohol vapor can cause
irritation of eyes, nose and throat. Eye irritation may be accompanied by
sensitivity to light and pain in eyeball. The pain may not begin until 6
hours after exposure. Contact with the liquid may cause first and second
degree burns of skin and blister formation. Areas of contact will become
swollen and painful and local muscle spasms may occur (Weiss 1980, p. 63).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 28).
SECTION VI -- USE INFORMATION
Allyl alcohol is used in the production of allyl esters, which are used as
monomers and prepolymers in the manufacture of resins and plastics. It is
also used in the preparation of Pharmaceuticals, organic synthesis of
glycerol and acrolein, and as a fungicide and herbicide (*SRI; *Merck
1976; *Browning 1965).
-------
CAS Registry Number: 107-18-6
Page 4 of 4
ALLYL ALCOHOL
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Wear positive pressure breathing apparatus
and special protective clothing. Isolate for 1/2 mile in all directions
if tank car or truck is involved in fire. Shut off ignition sources; no
flares, smoking or flames in hazard area. Do not touch spilled material;
stop leak if you can do so without risk. Use water spray to reduce
vapors. Small spills: absorb with sand or other noncombustible absorbent
material and place into containers for later disposal. Large spills:
dike far ahead of spill for later disposal (DOT 1984, Guide 28).
-------
CAS Registry Number: 107-20-0
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- CHLOROACETALDEHYDE
CAS Registry Number: 107-20-0
Synonyms: 2-Chloro-l-Ethanal; 2-Chloroacetaldehyde; Acetaldehyde, Chloro-;
Chloroacetaldehyde Monomer; Chloroaldehyde; Chloroethanal;
Monochloroacetaldehyde
Chemical Formula: C H CIO
Molecular Weight: 78.50
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air 1 ppm ceiling limit (*NIOSH/RTECS 1985)
ACGIH TLV: 1 ppm ceiling limit (*ACGIH 1984)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (mouse)
21 mg/kg (*NIOSH/RTECS 1985)
SECTION II - PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 185-187°F, 85-86°C (*Merck 1983)
Specific Gravity (H 0=1): 1.19 at 25°C/25°C (Sax 1984, p. 675)
Vapor Pressure (mmHg): 100 at 20°C (NIOSH/OSHA 1978, p. 64)
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (ACGIH 1980a, p. 84)
Appearance and Odor: Clear, colorless liquid (*ACGIH 1980a); acrid,
penetrating odor (*Merck 1983).
-------
CAS Registry Number: 107-20-0
Page 2 of 3
CHLOROACETALDEHYDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 190°F, 88°C (no method given) (Sax 1984, p.
675)
Flammable Limits: Moderate fire hazard when exposed to heat or flame
(Sax 1984, p. 676)
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Extinguish with water, foam, carbon dioxide, or
dry chemical (Sax 1984, p. 676). Large fires use water spray, fog, or
foam (*DOT 1984).
Special Fire Fighting Procedures: Wear positive pressure breathing
apparatus and special protective clothing. Dike fire control water for
later disposal; do not scatter the material (-DOT 1984).
Unusual Fire and Explosion Hazards: This material may burn but does
not ignite easily. Cylinders may explode in the heat of fire ("DOT 1984)
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Reacts with oxidizing materials
(Sax 1984, p. 676).
Hazardous Decomposition or Byproducts: When heated to decomposition or
on contact with acids or acid fumes, the compound evolves highly toxic
chloride fumes. Some organic chlorides decompose to yield phosgene (*Sax
1979).
Hazardous Polymerization: May Occur: Yes (*Merck 1983)
May Not Occur:
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Sax 1975)
-------
CAS Registry Number: 107-20-0
Page 3 of 3
CHLOROACETALDEHYDE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): On single, prolonged, or
repeated exposure, it presents serious eye hazards. Vapor concentrations
which produce eye, nose, and throat irritation are attainable at room
conditions. It does have mutagenic effects (ACGIH 1980a, p. 82).
Signs and Symptoms of Exposure: Inhalation exposure causes eye, nose
and throat irritation (*ACGIH 1980a). On contact, the material is capable
of causing marked to severe burns (ACGIH 1980a, p. 82).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site (*DOT 1984).
In case of ingestion, dilute with milk or water. Do not induce vomiting
(*Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
It is used as a chemical intermediate (*SRI); in the manufacture of
2-aminothiazole (-Merck 1983) and as a fungicide (*Hawley 1981).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation of vapors (see Section V above). Do not touch spilled
material; stop leak; use water spray to reduce vapors. Small spills:
take up with sand or other noncombustible absorbent material and place
into containers for later disposal. Large spills: dike far ahead of
spill for later disposal. Keep unnecessary people away; isolate hazard
area and deny entry. Stay upwind; keep out of low areas. Ventilate
closed spaces before entering them. Wear positive pressure breathing
apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes
(*DOT 1984).
-------
CAS Registry Number: 107-30-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CHLOROMETHYL METHYL ETHER
CAS Registry Number: 107-30-2
Synonyms: Chlorodimethyl Ether; Chlororaethoxymethane; CMME; Dimethyl-
chloroether; Ether, Chloromethyl Methyl; Ether Dimethyl Chloro; Methane,
Chloromethoxy-; Methoxychloromethane; Methoxymethyl Chloride;
Methylchloromethyl Ether; Methylchloromethyl Ether, Anhydrous;
Monochlorodimethyl Ether; Monochloromethyl Methyl Ether
Chemical Formula: C H CIO
Molecular Weight: 80.52
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Industrial substance suspect of carcinogenic
potential for humans (ACGIH 1984, p. 43). Toxicity information: LC
inhalation (rat) 0.182 mg/liter/7 hours (-NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 138°F, 59°C (»IARC 1972-1985)
Specific Gravity (H 0=1): 1.0605 at 20/4°C (*IARC 1972-1985)
Vapor Pressure (mmHg): Not Found
Melting Point: -154.3°F, -103.5°C (*Encyc Occupat Health and Safety
1971)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 107-30-2
Page 2 of 4
CHLOROMETHYL METHYL ETHER
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Decomposes (Weast 1979, p. C-300)
Appearance and Odor: Colorless liquid with an irritating odor (*IARC
1972-1985, *CHRIS 1978)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 0°C (OC) (''-CHRIS 1978); less than 73.4°F
(Sax 1984, p. 738)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with dry chemicals, foam, or carbon
dioxide. Water may be ineffective in extinguishing fire (*CHRIS 1978).
Special Fire Fighting Procedures: Move container from fire area. Dike
fire control water for later disposal; do not scatter material. Cool
containers that are exposed to flames with water. Withdraw immediately in
case of rising sound from venting safety device or any discoloration of
tank due to fire (-DOT 1984).
Unusual Fire and Explosion Hazards: Flammable/combustible material;
may be ignited by heat, sparks, or flames. Vapors may travel to a source
of ignition and flash back. Container may explode in heat of fire (*DOT
1984). In addition to the risk of explosion, when air mixtures of ether
vapors are heated or exposed to flame or sparks, they tend to form
peroxides. Ethers containing peroxides can detonate when heated ("Sax
1975). Unburned material may form powerful tear gas. When wet, also
forms irritating formaldehyde gas (Weiss 1980, p. 251).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-'-CHRIS 1978)
Conditions to Avoid: Decomposing heat (Sax 1984, p. 738)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Evolves formaldehyde and
hydrogen chloride ('-CHRIS 1978). When heated to decomposition, it emits
toxic fumes of chlorides (Sax 1984, p. 738).
-------
CAS Registry Number: 107-30-2
Page 3 of 4
CHLOROMETHYL METHYL ETHER
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 251)
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Yes (*DOT 1984)
Ingestion: Yes (*DOT 1984)
Health Hazards (Acute, Delayed, and Chronic): The principal effect is
irritation. The liquid causes severe irritation of eyes and skin; and
vapor exposure of 100 ppm is severely irritating to eyes and nose. This
level is dangerous to life in 4 hours. Pulmonary edema or pneumonia may
cause death (*Encyc Occupat Health and Safety 1971). There was increased
death rate from respiratory cancer among exposed victims ('VIARC 1972-1985)
and it is a regulated carcinogen ("Aldrich 1984).
Signs and Symptoms of Exposure: Sore throat, fever, chills, difficulty
in breathing (*Patty 1963), pulmonary edema with frothy exudate (*Gosselin
1976), and severe skin and eye irritation (*Encyc Occupat Health and
Safety 1983) have been reported.
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes
(-DOT 1984).
SECTION VI -- USE INFORMATION
Intermediate in synthesis of chloromethylated compounds (*IARC 1972-1985);
anion-exchange resins; dodecylbenzyl chloride; and chloromethylating
reaction mixtures (*SRI).
-------
CAS Registry Number: 107-30-2
Page 4 of 4
CHLOROMETHYL METHYL ETHER
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Wear positive pressure breathing apparatus and full protective clothing.
Shut off ignition sources; no flares, smoking, or flames. Do not touch
spilled material; stop leak if you can do so without risk. Use water
spray to reduce vapors. Absorb small spills with sand or other
noncombustible absorbent material and place into containers for later
disposal. Dike far ahead of large spills for later disposal (*DOT 1984).
Flood with water. Rinse with sodium bicarbonate or lime solution (*CHRIS
1978).
-------
CAS Registry Number: 107-44-8
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- SARIN
CAS Registry Number: 107-44-8
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 3, p. 122)
Phosphonofluoridic Acid, Methyl-, Isopropyl Ester; GB; IMPF;
Isopropoxymethylphosphoryl Fluoride; Isopropyl Methanefluorophosphonate;
Isopropyl Methylfluorophosphate; Isopropyl-Methyl-Phosphoryl Fluoride;
Methylphosphonofluoridic Acid Isopropyl Ester; MFI; Phosphine Oxide,
Fluoroisopropoxymethyl; Phosphoric Acid, Methylfluoro-, Isopropyl Ester; Sarin
II; T-144; T-2106; TL 1618; Trilone 46
Chemical Formula: C.H FO P
Molecular Weight: 140.11
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(guinea pig) 0.128 mg/liter for 2 minutes (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 297°F, 147°C (Merck 1983, p. 1204)
Specific Gravity (H20=l): 1.10 at 20°C/4°C (Merck 1983, p. 1204)
Vapor Pressure (mmHg): 2.9 at 25°C (U.S. Army 1975, p. 3-4)
Melting Point: -71°F, -57°C (Merck 1983, p. 1204)
Vapor Density (AIR=1): 4.86 (U.S. Army 1975, p. 3-4)
Evaporation Rate (Butyl acetate=l): About the same as water (U.S. Army
1975, p. 3-4)
-------
CAS Registry Number: 107-44-8
Page 2 of 3
SARIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Miscible with and hydrolyzed by water (Merck
1983, p. 1204)
Appearance and Odor: Liquid (Merck 1983, p. 1204). A colorless liquid
and vapor. Almost no odor in pure state (U.S. Army 1975, p. 3-3 to 3-4).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Non-flammable (U.S. Army 1975, p. 3-4)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with foam, carbon dioxide, and dry
chemical (Sax 1984, p. 1662)
Special Fire Fighting Procedures: Protective clothing and respiratory
protection (U.S. Army 1975, p. 3-5).
Unusual Fire and Explosion Hazards: Non-flammable (U.S. Army 1975, p.
3-5)
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (U.S. Army 1975, p. 3-4)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Slightly corrosive to steel
(U.S. Army 1975, p. 3-4). Hydrolyzed by water (Merck 1983, p. 1204).
Hazardous Decomposition or Byproducts: Acidic conditions produce
hydrogen fluoride; alkaline conditions produce isopropyl alcohol and
polymers (U.S. Army 1975, p. 3-4). When heated to decomposition or
reacted with steam, it emits very toxic fumes of fluorides and oxides of
phosphorus (Sax 1984, p. 1662).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 107-44-8
Page 3 of 3
SARIN
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (U.S. Army 1975, p. 3-4)
Skin: Yes (U.S. Army 1975, p. 3-4)
Ingestion: Yes (U.S. Army 1975, p. 3-4)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic; lethal
dose in humans may be as low as 0.01 mg/kg. Extremely active
cholinesterase inhibitor. Toxic effects similar to, but more severe than
those of parathion (Merck 1983, p. 1204). Death within 15 minutes after
fatal dose is absorbed (U.S. Army 1975, p. 3-4).
Signs and Symptoms of Exposure: Symptoms include difficulty in
breathing, drooling, excessive sweating, nausea, vomiting, cramps,
involuntary defecation and urination, twitching, jerking, staggering,
headache, confusion, drowsiness, coma, convulsion, dimness of vision, and
pinpoint pupils (U.S. Army 1975, p. 3-3).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Immediate decontamination of the
smallest drop is essential. Vapor penetrates the skin (U.S. Army 1975, p.
3-4). Toxic effects are similar to parathion (Sax 1984, p. 1662).
Treatment for parathion is as follows: move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Quick-acting military chemical nerve agent (U.S. Army, p. 3-4). Chemical
warfare agent (Merck 1983, p. 1204).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Protective mask with self-contained breathing apparatus and full
protective clothing (U.S. Army 1975, p. 3-4). Rapidly hydrolyzed by
dilute aqueous sodium hydroxide or sodium carbonate forming relatively
non-toxic products. Water alone removes the fluorine atom producing a
non-toxic acid (Merck 1983, p. 1204). Decontaminants include bleach
slurry, dilute alkali, hot soapy water, steam and ammonia (U.S. Army 1975,
p. 3-4).
-------
CAS Registry Number: 107-49-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- TEPP
CAS Registry Number: 107-49-3
Synonyms: Pyrophosphoric Acid, Tetraethyl Ester (Dry Mixture);
Bis-0,0-Diethylphosphoric Anhydride; Bladan; Diphosphoric Acid, Tetraethyl
Ester; ENT 18,771; Ethyl Pyrophosphate [ET4P207]; Ethyl Pyrophosphate, Tetra-;
Fosvex; Grisol; Hept; Hesamite; Hexamite; Killax; Kilmite 40; Lethalaire G-52;
Lirohex; Mortopal; Nifos; Nifos T; Nifost; TEP; Terrasytam; Tetraethyl
Diphosphate; Tetraethylpyrophosphate; Tetrastigmine; Tetron; Tetron-100;
Vapotone; Vaptone
Chemical Formula: CQHoriO..P0
o i\J I /
Molecular Weight: 290.22
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: 0.05 mg/m3 (NIOSH/OSHA 1978, p. 174)
ACGIH TLV: TWA 0.004 ppm, 0.05 mg/m3; STEL 0.01 ppm, 0.2 mg/m3
(ACGIH 1983, p. 32)
IDLH: 10 mg/m3 (NIOSH/OSHA 1978, p. 174)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 280°F, 138°C at 2.3 mm (*Merck 1983)
Specific Gravity (H 0=1): 1.185 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): 4.7 x 10"4 at 30°C (*Merck 1976)
Melting Point: 32°F, 0°C (NIOSH/OSHA 1978, p. 174)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 107-49-3
Page 2 of 3
TEPP
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Freely soluble (*Weast 1979); quickly hydrolyzed
(Merck 1983, p. 1317)
Appearance and Odor: Colorless liquid (*Spencer 1982); faint fruity
odor (*CHRIS 1978). Technical product is a dark amber-colored liquid
(^Worthing 1979).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Not combustible (NIOSH/OSHA 1978, p. 174)
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog, or foam (*DOT 1984).
Special Fire Fighting Procedures: Wear self-contained breathing
apparatus and full protective clothing. Move container from fire area if
you can do it without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (*DOT 1984).
Unusual Fire and Explosion Hazards: Extremely toxic fumes of unburned
material and phosphoric acid (*CHRIS 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Incompatible with strong
oxidizers (NIOSH/OSHA 1978, p. 174).
Hazardous Decomposition or Byproducts: Highly toxic gases and vapors
of unburned material and phosphoric acid are formed in fires (*CHRIS 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 107-49-3
Page 3 of 3
TEPP
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (NIOSH/OSHA 1978, p. 175)
Skin: Yes (NIOSH/OSHA 1978, p. 175)
Ingestion: Yes (NIOSH/OSHA 1978, p. 175)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
super toxic. Probable oral lethal dose in humans is less than 5 rag/kg (a
taste) for a 150 Ib. person (*Gosselin 1976). A small drop in the eye may
cause death (*Clarke 1981). Small doses at frequent intervals are
additive (*Sax 1979). Poisonings always develop at a rapid rate
(-Gosselin 1976). It is a cholinesterase inhibitor (*Merck 1983).
Signs and Symptoms of Exposure: Symptoms are similar to those for
parathion, including nausea, vomiting, abdominal cramps, excessive
salivation, headache, giddiness, vertigo, weakness, runny nose, sensation
of tightness in the chest, blurring or dimness of vision, weakness and
twitching of muscles, confusion, difficulty in breathing, convulsions, and
coma (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. If contact with material occurs, flush skin or eyes with running
water for at least 15 minutes. Remove and isolate contaminated clothing.
Keep victim quiet and maintain normal body temperature. Effects may be
delayed. Keep victim under observation (*DOT 1984).
SECTION VI -- USE INFORMATION
It is used as an insecticide and a rodenticide (*SRI; *Hawley 1981). No
rodenticide use registered in the U.S. (USEPA/Active Ingredients 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
In case of spills, stay upwind; stay out of low areas. Use water spray to
reduce vapors, but do not put water on spill area. Ventilate closed
spaces before entering them. Wear positive pressure breathing apparatus
and special protective clothing. Do not touch spilled material; stop leak
if possible. Take up spills with noncombustible absorbent material. For
large spills dike far ahead (*DOT 1984).
-------
CAS Registry Number: 108-05-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- VINYL ACETATE MONOMER
CAS Registry Number: 108-05-4
Synonyms: 1-Acetoxyethylene; Acetic Acid Ethenyl Ester; Acetic Acid Vinyl
Ester; Acetic Acid, Ethenyl Ester; Ethenyl Acetate; VAC; Vinyl A Monomer;
Vinyl Acetate HQ; Vyac; Zeset T
Chemical Formula: C,H,0-
462
Molecular Weight: 86.09
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 10 ppm (30 mg/m3); STEL 20 ppm (60 mg/m3) (*ACGIH
1980)
IDLH: Not Found
Other Limits Recommended: NIOSH recommended air ceiling
concentration: 15 mg/m3 for 15 minutes (*NIOSH 1977-Present). Maximum
Air Concentration (USSR): 10 mg/m3 (Encyc Occupat Health and Safety
1983, p. 2260). Toxicity information: LC, inhalation (rat)
14 mg/liter/4 hours; LC inhalation (mouse) 5.4 mg/liter/4 hours
(-NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 162-163°F, 72-73°C (*Merck 1976)
Specific Gravity (H20=l): 0.932 at 20/4°C (*Merck 1976)
Vapor Pressure (mmHg): 83 at 20°C; 140 at 30°C (*Verschueren 1983)
Melting Point: -136°F, -93.2°C (*Weast 1979)
Vapor Density (AIR=1): 3.0 (*NFPA 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 1 g/50 mL at 20°C (*Merck 1983)
-------
CAS Registry Number: 108-05-4
Page 2 of 4
VINYL ACETATE MONOMER
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless to white mobile liquid (unstable) or
blue-green (stable) (*Sax 1975; *Weast 1979). Sweet, pleasant, fruity
characteristic odor in small quantities (*CHRIS 1978) or a sour, sharp
smell (-Verschueren 1983).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 18°F, -8°C (CC) (*NFPA 1978); 0.5-0.9°C
(TOC) (*Kirk-Othmer 1978)
Flammable Limits:
LEL: 2.6% (*Encyc Occupat Health and Safety 1983)
DEL: 13.4% (*Encyc Occupat Health and Safety 1983)
Extinguishing Methods: Small fires: extinguish with dry chemical,
carbon dioxide, water spray, fog, or alcohol foam. Large fires: water
spray, fog, or alcohol foam (-DOT 1984).
Special Fire Fighting Procedures: Wear self-contained (positive
pressure if available) breathing apparatus and full protective clothing.
Spray cooling water on containers that are exposed to flames until well
after the fire is out. For massive fire in cargo area, use unmanned hose
holder or monitor nozzles; if this is impossible, withdraw from area and
let fire burn. Withdraw immediately in case of rising sound from venting
safety device or any discoloration of tank due to fire (DOT 1984, Guide
26).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits acrid fumes ("Sax 1975). Highly dangerous when exposed to .heat,
flames or oxidizers; explosion hazard with strong acids.and strong.
oxidizers (Sax 1984, p. 85).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Merck 1976)
Conditions to Avoid: Avoid light or any polymerizing initiator
(*Merck 1976, *Bretherick 1979).
Incompatibility (Materials to Avoid): Incompatible with alumina
(-Bretherick 1979); oxidizing materials (*Sax 1975); 2-aminoethanol,
chlorosulfonic acid; ethyleneimine; 36% hydrochloric acid; 48.7%
hydrofluoric acid; 70% nitric acid; oleum; 96% sulfuric acid; ethylene
diamine; peroxides (*NFPA 1978); and silica gel (*Bretherick 1979).
-------
CAS Registry Number: 108-05-4
Page 3 of 4
VINYL ACETATE MONOMER
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it burns and emits acrid fumes (*Sax 1975).
Hazardous Polymerization: May Occur: Yes (*Kirk-Othmer 1978)
May Not Occur:
Conditions to Avoid: Polymerization can be initiated by organic
and inorganic peroxides; azo compounds; redox systems (including
organometallic components); light; and high energy radiation
(*Kirk-Othmer 1978).
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Sax 1975)
Skin: Yes (Sax 1984, p. 85)
Ingestion: Yes (*Lefaux 1968)
Health Hazards (Acute, Delayed, and Chronic): Vinyl acetate has been
related to reproductive abnormalities ("Talakina 1977). It is a skin and
upper respiratory tract irritant ("ACGIH 1980) and a central nervous
system depressant ("Rumack 1975 to Present). Exposure caused gradual
deterioration of heart muscles ("Agaronyon 1980).
Signs and Symptoms of Exposure: Symptoms include abnormal heart beat,
fainting spells, pain around the heart area ("Agaronyan 1980), coughing,
hoarseness, blistering ("ACGIH 1980), cornea burns (''-Grant 1974),
dizziness, confusion and defatting of the skin (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush eyes with running water for at least 15 minutes. Wash
skin with soap and water. Remove and isolate contaminated clothing and
shoes at the site (DOT 1984, Guide 26).
-------
CAS Registry Number: 108-05-4
Page 4 of 4
VINYL ACETATE MONOMER
SECTION VI -- USE INFORMATION
Monomer for making poly (vinyl acetate) and vinyl acetate copolymers,
which are used in water based paints, adhesives, paper coatings, or
nonwoven binders and applications not requiring service at extreme
temperatures (*Kirk-Othmer 1978). In polymerized form it is used for
plastic masses, films, and lacquers ("Merck 1983). It is also used in the
production of emulsion paint ingredients, finishing and impregnation
materials and glue (*Encyc Occupat Health and Safety 1983).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
When handling use self-contained respirator, chemical safety goggles
and/or face shield, rubber gloves, apron and boots. Keep unnecessary
people away and stay upwind. Isolate for 1/2 mile in all directions if
tank car or truck is involved in fire. For spill or leaks shut off
ignition sources; no flares, smoking or flames in hazard area. Use water
spray to reduce vapors. Absorb spills with noncombustible absorbent
material (DOT 1984, Guide 26).
-------
CAS Registry Number: 108-23-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ISOPROPYL CHLOROFORMATE
CAS Registry Number: 108-23-6
Synonyms: Carbonochloride Acid, 1-Methylethyl Ester; Carbonochloridic
Acid, 1-Methylethyl Ester; Chloroformic Acid Isopropyl Ester; Formic Acid,
Chloro-, Isopropyl Ester; Isopropyl Chlorocarbonate; Isopropyl Chloromethanoate
Chemical Formula: C H CIO
Molecular Weight: 122.55
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat) 1 mg/liter/5 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 220°F, 104.6°C at 761 mmHg (*Weast 1979)
Specific Gravity (H20=l): 1.08 (-Patty 1963)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): 4.2 ('-Patty 1963)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble in water (-Weast 1979)
Appearance and Odor: Colorless liquid (*Hawley 1977)
-------
CAS Registry Number: 108-23-6
Page 2 of 3
ISOPROPYL CHLOROFORMATE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 60.1°F, 15.6°C (*Clayton and Clayton
1981-1982)
Flammable Limits: Flammable; may be ignited by heat, sparks or flame
(DOT 1984, Guide 29)
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Keep unnecessary people away and isolate hazard
area. Stay upwind and keep out of low areas. Wear self-contained
(positive pressure if available) breathing apparatus and full protective
clothing. For small fires, use dry chemical, carbon dioxide, water spray
or foam. For large fires, use water spray, fog or foam. Do not get water
inside container. Cool containers exposed to flame with water until well
after fire is out. Withdraw immediately in case of rising sound from
venting safety device or any discoloration of tank due to fire (DOT 1984,
Guide 29).
Special Fire Fighting Procedures: Isolate for 1/2 mile in all
directions if tank car or truck is involved in fire (DOT 1984, Guide 29).
Unusual Fire and Explosion Hazards: Extremely dangerous; this chemical
has exploded while stored in refrigerator (*Sax 1979). Vapor explosion
hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or
explosion hazard (DOT 1984, Guide 29).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Patty 1963)
Stable:
Conditions to Avoid: Avoid phosgene (*Sax 1979)
Incompatibility (Materials to Avoid): Reacts violently with phosgene
(*Sax 1979).
Hazardous Decomposition or Byproducts: Like other chlorides (Sax 1984,
p. 1657) when heated to decomposition or on contact with acids or acrid
fumes, they evolve highly toxic chloride fumes (Sax 1984, p. 672).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 108-23-6
Page 3 of 3
ISOPROPYL CHLOROFORMATE
SECTION V - HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1657)
Skin: Yes (Sax 1984, p. 1657)
Ingestion: Yes (Sax 1979, p. 1657)
Health Hazards (Acute, Delayed, and Chronic): Acute: highly toxic by
inhalation, ingestion and skin absorption (Sax 1984, p. 1657). Delayed:
can produce delayed pulmonary edema (2-24 hours after exposure) similar to
that produced by phosgene (*Patty 1963; *Rumack 1975 to Present).
Inhalation of material may cause death or permanent injury (*Sax 1979).
Signs and Symptoms of Exposure: Eye irritation, irritation of upper
respiratory tract and surface burns have been observed. Eye irritation
may persist after exposure ceases, and skin sensitization may occur
(*Patty 1963). Inhalation exposures at elevated concentrations cause
death by immediate lung damage, lower concentrations cause difficult
breathing, collapse, and convulsions (Clayton and Clayton 1981-1982, p.
2390).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air. Obtain
emergency medical care immediately. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes
(DOT 1984, Guide 29).
SECTION VI -- USE INFORMATION
Used as a chemical intermediate for free-radical polymerization initiators
and in organic synthesis ("Hawley 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
In case of spills or leaks, shut off ignition sources and keep away
flares, smoke or flames. Do not touch spilled material. Wear
self-contained (positive pressure if available) breathing apparatus and
full protective clothing. Use water to reduce vapors but do not get water
inside containers. Take up small spills with sand or other noncombustible
absorbent material and place in containers for later disposal. For large
spills, dike far ahead of spill for later disposal (DOT 1984, Guide 29).
-------
CAS Registry Number: 108-67-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- MESITYLENE
CAS Registry Number: 108-67-8
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 668) Benzene,
1,3,5-Trimethyl-; Fleet-X; 1MB; Sym-Trimethylbenzene; 1,3,5-Trimethylbenzene;
Tr imethyIbenzo1
Chemical Formula: C H .
Molecular Weight: 120.21
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 25 ppm; STEL 35 ppm (NIOSH/RTECS 1983, Volume 2, p. 668)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC5~ inhalation
(rat) 0.024 mg/liter/4 hours (''-NIOSH/RTECS 1985) (SUSPECT)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 328.5°F, 164.7°C (Sax 1984, p. 1758)
Specific Gravity (H20=l): 0.8637 at 20°C/4°C (Sax 1984, p. 1758)
Vapor Pressure (mmHg): Not Found
Melting Point: -48.6°F, -44.8°C (Sax 1984, p. 1758)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.002 g in 100 mL (Merck 1983, p. 844)
Appearance and Odor: Liquid with peculiar odor (Sax 1984, p. 1758)
-------
CAS Registry Number: 108-67-8
Page 2 of 4
MESITYLENE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray, or alcohol foam. Large fires: water spray, fog, or alcohol
foam (DOT 1984, Guide 26).
Special Fire Fighting Procedures: Move container from fire area if you
can do so without risk. Spray cooling water on containers that are
exposed to flames until well after fire is out. For massive fire in cargo
area, use unmanned hose holder or monitor nozzles; if this is impossible,
withdraw from area and let fire burn. Withdraw immediately in case of
rising sound from venting safety device or any discoloration of tank due
to fire. Isolate for one-half mile in all directions if tank car or truck
is involved in fire (DOT 1984, Guide 26).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits acrid smoke and fumes (Sax 1984, p. 1758). Flammable/combustible
material; may be ignited by heat, sparks or. flames. Vapors may travel to
a source of ignition and flash back. Container may explode in heat of
fire. Vapor explosion hazard indoors, outdoors or in sewers. Runoff to
sewer may create fire or explosion hazard (DOT 1984, Guide 26).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Nitric acid; violent reaction
results (Sax 1984, p. 1758)
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits acrid smoke and fumes (Sax 1984, p. 1758).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 108-67-8
Page 3 of 4
MESITYLENE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (ACGIH 1980, p. 415)
Skin: Not Found
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Acute -- lowest toxic
concentration for humans is 10 ppm, resulting in central nervous system
effects (Sax 1984, p. 1758). Liquid is primary skin irritant (ACGIH 1980,
p. 269). Liquid deposition in lungs causes chemical pheumonitis. Delayed
or chronic health hazard is possible asthmatic bronchitis (ACGIH 1980, p.
415).
Signs and Symptoms of Exposure: Nervousness, tension, anxiety,
asthmatic bronchitis and skin irritation (ACGIH 1980, p. 415).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush eyes with running water for at least 15 minutes. Wash
skin with soap and water. Remove and isolate contaminated clothing and
shoes at the site (DOT 1984, Guide 26).
SECTION VI -- USE INFORMATION
Chemical raw materials, paint thinner, solvent, motor fuel component
(Clayton and Clayton 1981-82, p. 3300).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Wear self-contained (positive pressure if
available) breathing apparatus and full protective clothing. If water
pollution occurs, notify appropriate authorities. Shut off ignition
sources; no flares, smoking or flames in hazard area. Stop leak if you
can do so without risk. Use water spray to reduce vapors. Small spills:
absorb with sand or other noncombustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 26).
-------
CAS Registry Number: 108-67-8
Page 4 of 4
MESITYLENE
COMMENTS
Sources searched but no information found:
Weiss 1980
Hawley 1981
Hayes 1982
Encyc Occupat Health and Safety 1983
NIOSH/OSHA 1978
Doull 1980
Student 1981
NFPA 1984
Weast 1979
-------
CAS Registry Number: 108-91-8
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CYCLOHEXYLAMINE
CAS Registry Number: 108-91-8
Synonyms: Aminocyclohexane; Aminohexahydrobenzene; Benzenamine,
Hexahydro-; CHA; Cyclohexanamine; Hexahydroaniline; Hexahydrobenzenamine
Chemical Formula: C,H10N
D 1 j
Molecular Weight: 99.17
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 10 pprn (40 mg/m3) (Skin) (*ACGIH 1983)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (rat) 156
mg/kg; U>50 dermal (rat) 320 mg/kg (NIOSH/RTECS 1983, Volume 1, p. 1010),
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 274.1°F, 134.5°C (*Merck 1983)
Specific Gravity (H20=l): 0.8o47 at 25°C/25°C (*Merck 1983)
Vapor Pressure (mmHg): Not Found
Melting Point: 0.1°F, -17.7°C (*Merck 1983)
Vapor Density (AIR=1): 3.42 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (*Merck 1983)
Appearance and Odor: A colorless to yellow liquid with a strong,
fishy, amine odor (*NFPA 1978; *Merck 1983).
-------
CAS Registry Number: 108-91-8
Page 2 of 3
CYCLOHEXYLAMINE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 88°F, 31°C (CC) (-NFPA 1978)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Use dry chemical, alcohol foam or carbon
dioxide; water may be ineffective (*NFPA 1978).
Special Fire Fighting Procedures: Move container from fire area if you
can do it without risk. Stay away from ends of tanks. Cool containers
that are exposed to flames with water from the side until well after fire
is out. Withdraw immediately in case of rising sound from venting safety
device or any discoloration of tank due to fire. Keep unnecessary people
away; isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Wear self-contained (positive pressure if available) breathing
apparatus and full protective clothing. Isolate for one-half mile in all
directions if tank car or truck is involved in fire (DOT 1984, Guide 58).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits highly toxic fumes (Sax 1984, p. 834). Vapor may travel a
considerable distance to source of ignition and flash back (*NFPA 1978).
Toxic oxides of nitrogen are produced during combustion (Student 1984, p.
162).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Physical damage, storage with oxidizing
material (*NFPA 1978).
Incompatibility (Materials to Avoid): Nitric acid; reacts vigorously
with oxiding materials (Sax 1984, p. 834).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes (*Sax 1975).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 108-91-8
Page 3 of 3
CYCLOHEXYLAMINE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 298)
Skin: Yes (Hawley 1981, p. 298)
Ingestion: Yes (Hawley 1981, p. 298)
Health Hazards (Acute, Delayed, and Chronic): This is classified as
very toxic -- probable oral lethal dose is 50-500 mg/kg or between 1
teaspoon and 1 ounce for a 70 kg (150 Ib.) person ("Gosselin 1976). It is
considered a nerve poison (*LeFaux 1968). This is a weak
methemoglobin-forming substance ('VACGIH 1980).
Signs and Symptoms of Exposure: Light-headedness, drowsiness, anxiety,
apprehension, nausea, slurred speech, vomiting, pupillary dilation, severe
skin irritation (*ACGIH 1980; *Clayton and Clayton 1981-82).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Keep victim quiet and maintain normal body temperature (DOT
1984, Guide 68).
SECTION VI -- USE INFORMATION
Used in organic synthesis, manufacturing of pesticides, plasticizers,
emulsifying agents, dry-cleaning soaps, acid gas absorbents (*Merck 1983);
corrosion inhibitor in boiler water and oil fields; chemical intermediate
for rubber-processing chemicals, dyes, cyclamate artificial sweeteners
(non-U.S. use) and for herbicide; processing agent for nylon fiber
production (*SRI). Not registered as a pesticide in the U.S. (USEPA/
Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Wear self-contained (positive pressure if
available) breathing apparatus and full protective clothing. Shut off
ignition sources; no flares, smoking or flames in hazard area. Do not
touch spilled material; stop leak if you can do it without risk. Use
water spray to reduce vapors. Small spills: take up with sand or other
non-combustible absorbent material and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 68).
-------
CAS Registry Number: 108-95-2
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PHENOL
CAS Registry Number: 108-95-2
Synonyms: Benzenol; Carbolic Acid; Hydroxybenzene; Izal;
Monohydroxybenzene; Monophenol; NCI-C50124; Oxybenzene; Phenic Acid; Phenyl
Alcohol; Phenyl Hydrate; Phenyl Hydroxide; Phenylic Acid; Phenylic Alcohol
Chemical Formula: C^H^O
o o
Molecular Weight: 94.11
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 5 ppm (skin) (-'-NIOSH 1977-Present)
ACGIH TLV: TWA 5 ppm, 19 mg/m3; STEL 10 ppm, 38 mg/m3 (ACGIH 1983,
p. 28)
IDLH: 100 ppm (NIOSH/OSHA 1978, p. 150)
Other Limits Recommended: TWA (air) 20 mg/m3, ceiling of
60 mg/m3/15 minutes for occupational exposure (*NIOSH 1977-Present); TWA
(skin) 5 ppm (19 mg/m3/8 hour) (*NIOSH 1976).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 359.1°F, 181.75°C (*Weast 1979)
Specific Gravity (H 0=1): 1.0722 at 20°/4°C (*Weast 1979)
Vapor Pressure (mmHg): 0.3513 at 25°C (*Sunshine 1969)
Melting Point: 109°F, 43°C (*Merck 1976)
Vapor Density (AIR=1): 3.24 (-''Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 93 g/liter at 25°C (*Morrison 1973)
-------
CAS Registry Number: 108-95-2
Page 2 of 3
PHENOL
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless crystals or white crystalline mass
(''•Merck 1976), with aromatic, somewhat sickening sweet and acrid odor
(-Clayton and Clayton 1981-82). It is liquefied by mixing with about 8%
water (Merck 1983, p. 1043).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 79°C (CC) (-Sunshine 1969)
Flammable Limits:
LEL: 1.7% (*CHRIS 1978)
UEL: 8.6% (*CHRIS 1978)
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray or foam (alcohol); large fires: water spray, fog or foam; use
water spray to cool containers in fire area ("Environment Canada 1981).
Special Fire Fighting Procedures: Move container from fire area if it
can be done without risk; fight fire from maximum distance; dike fire
control water for later disposal, do not scatter the material (DOT 1984,
Guide 55).
Unusual Fire and Explosion Hazards: Flammable vapors when heated
("NFPA 1978). Runoff from fire control water may give off poisonous gases
and cause pollution (-DOT 1984). Mixtures of 9-10% phenol in air are
explosive (*Clayton and Clayton 1981-82).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Decomposes slowly on air contact (*Merck
1976). Avoid contact with strong oxidizing agents ("CHRIS 1978).
Incompatibility (Materials to Avoid): Aluminum chloride/nitrobenzene
mixture, peroxodisulfuric acid, peroxomonosulfuric acid (*Bretherick
1979), and strong oxidizing agents ("CHRIS 1978).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 108-95-2
Page 3 of 3
PHENOL
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Encyc Occupat Health
and Safety 1971)
Skin: Yes (*NFPA 1978)
Ingestion: Yes (*NFPA 1978)
Health Hazards (Acute, Delayed, and Chronic): Toxic hazard rating is
very toxic: probable oral lethal dose (human) is 50-500 mg/kg (*Gosselin
1976). Ingestion of 1 gram has been lethal to humans (*Encyc Occupat
Health and Safety 1971). Lethal amounts may be absorbed through skin or
inhaled (*NFPA 1978). Industrial contact can cause chronic poisoning with
kidney and liver damage (''"Merck 1976).
Signs and Symptoms of Exposure: Burning pain in mouth and throat,
bloody diarrhea, pallor, sweating, weakness, headache, dizziness, ringing
in the ears, shock, profound fall in body temperature. Oral: sonorous
breathing, frothing at mouth and nose. Skin: pain followed by numbness
(-Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Persons affected
with hepatic or kidney diseases are.at a greater risk (*Clayton and
Clayton 1981-82). '
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing at site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed. Keep victim
under observation (*DOT 1984).
SECTION VI -- USE INFORMATION
Disinfectant, antiseptic, bactericide (*Merck 1976). Chemical
intermediate for phenolic resins, medicinals, and many other chemicals;
solvent for petroleum refining (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Spills must be disposed of immediately by properly protected personnel; no
others should remain in area. Flush with flooding quantities of water,
then use caustic soda solution for neutralization (*NFPA 1978). Wear
positive pressure breathing apparatus and special protective clothing.
Remove and isolate contaminated clothing, at the site (DOT 1984, Guide 55).
-------
CAS Registry Number: 108-98-5
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- THIOPHENOL
CAS Registry Number: 108-98-5
Synonyms: Benzene, Mercapto-; Benzenethiol; Mercaptobenzene; Phenol,
Thio-; Phenyl Mercaptan; Phenylthiol
Chemical Formula: C,H,S
0 D
Molecular Weight: 110.17
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.5 ppm, 2 mg/m3 (*ACGIH 1981)
IDLH: Not Found
Other Limits Recommended: Occupational exposure to benzenethiol
recommended standard: air ceiling concentration 0.5 mg/m3/15 minutes,
Toxicity information: LC inhalation (mouse) 0.126 mg/liter/4 hours
(*NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 334.9°F, 168.3°C (*Merck 1976)
Specific Gravity (H 0=1): 1.0728 at 25°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 1 at 18.6°C (Weast 1979, p. D-208)
Melting Point: 5.4°F, -14.8°C (*Weast 1979)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble in water (*Merck 1976)
Appearance and Odor: Water-white liquid (*Hawley 1977); repulsive,
penetrating, garlic-like odor especially when impure (*Merck 1976).
-------
CAS Registry Number: 108-98-5
Page 2 of 3
THIOPHENOL
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
. Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray or foam. Large fires: water spray, fog or foam. Move
container from fire area if you can do so without risk. Spray cooling
water on containers that are exposed to flames until well after fire is
out. Fight fire from maximum distance. Dike fire control water for later
disposal; do not scatter the material (DOT 1984, Guide 57).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing (DOT 1984, Guide 57).
Unusual Fire and Explosion Hazards: When heated to decomposition or on
contact with acids, it emits toxic fumes of sulfur oxides (Sax 1984, p.
368). May be ignited by heat, sparks or flames. Container may explode in
heat of fire. Vapor explosion and poison hazard indoors, outdoors or in
sewers (DOT 1984, Guide 57).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes. Oxidizes in air (*Merck 1976).
Stable:
Conditions to Avoid: Contact with acids (Sax 1984, p. 368).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of sulfur oxides (Sax 1984, p. 368).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 368)
Skin: Yes (Sax 1984, p. 368)
Ingestion: Yes (Sax 1984, p. 368)
-------
CAS Registry Number: 108-98-5
Page 3 of 3
THIOPHENOL
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Marked potential for
causing eye changes (*Encyc Occupat Health and Safety 1983). May cause
death (DASE 1980, p. 189)
Signs and Symptoms of Exposure: May cause death by pulmonary edema or
central nervous effects. Contact on skin causes redness, pain, skin
burns, =and dermatitis. Irritation of the eyes is common with pain,
redness, and blurred vision. Inhalation causes a sore throat, coughing,
shortness of breath, labored breathing, nausea, vomiting, dizziness and
headaches. Ingestion causes a sore throat, abdominal pain, nausea
vomiting, dizziness and weakness (DASE 1980, p. 189; Encyc Occup Health
and Safety 1983, p. 2172; Weiss 1980, p. 1166).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed, keep victim under observation (DOT 1984, Guide 57).
SECTION VI -- USE INFORMATION
Pesticide (*Rumack 1975 to Present); intermediate for pesticides, alkyl
phenyl sulfides, polymers, and other materials (*SRI); pharmaceutical
synthesis (Hawley 1981, p. 1020); mosquito larvicide (Sax 1984, p. 368).
Not registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors (see Section V above). Shut off ignition sources;
no flares, smoking, or flames in hazard area. Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand or other non-combustible
absorbent material and place into containers for later disposal.. Small
dry spills: with clean shovel place material into clean, dry container
and cover; move containers from spill area. Large spills: dike far ahead
of spill for later disposal. Keep unnecessary people away; isolate hazard
area and deny entry. Stay upwind; keep out of low areas. Ventilate
closed spaces before entering them. Wear positive pressure breathing
apparatus and special protective clothing (DOT 1984, Guide 57).
-------
CAS Registry Number: 109-19-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- BUTYL ISOVALERATE
CAS Registry Number: 109-19-3
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 586) Isovaleric
Acid, Butyl Ester; Butanoic Acid, 3-Methyl-, Butyl Ester; n-Butyl
Isopentanoate; n-Butyl Isovalerate; 1-Butyl Isovalerate; Butyl Isovalerianate;
Butyl 3-Methylbutyrate
Chemical Formula: CnH,000
y io z
Molecular Weight: 158.27
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (rabbit)
8.2 mg/kg (*NIOSH/RTECS 1985) (SUSPECT)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 347.9°F, 175.5°C at 755 mmHg (Beilstein 1954, p. 698)
Specific Gravity (H20=l): 0.87 (Sax 1984, p. 1673)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): 5.45 (Sax 1984, p. 1673)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Not Found
-------
CAS Registry Number: 109-19-3
Page 2 of 3
BUTYL ISOVALERATE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Extinguish with alcohol foam, dry chemical,
spray, mist, or fog (Sax 1984, p. 1673).
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: A moderate fire hazard via heat,
flame (sparks) and oxidizers (Sax 1984, p. 1673).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 1673)
Health Hazards (Acute, Delayed, and Chronic): This ester is a skin
irritant, and has a high oral toxicity (Sax 1984, p. 1673). Toxicity
information of this chemical is grouped with N-butyl acetate. It is
classified as moderately toxic. Probable oral lethal dose for humans is
0.5 to 5 g/kg (between 1 ounce and a pint) for a 150 Ib. person. It is a
mild irritant and central nervous depressant. Also, it is less toxic than
the parent alcohol (Gosselin 1984, p. 11-201).
-------
CAS Registry Number: 109-19-3
Page 3 of 3
BUTYL ISOVALERATE
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Symptoms include headache, muscle
weakness, giddiness, nausea, vomiting, confusion, delirium, coughing,
labored and difficult breathing, coma and even death (Gosselin 1984, p.
111-14).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Treat similarly to higher alcohol
exposure (Gosselin 1984, p. 11-201). Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush eyes with running water for at least 15 minutes. Wash
skin with soap and water. Remove and isolate contaminated clothing and
shoes at the site (DOT 1984, Guide 26).
SECTION VI -- USE INFORMATION
Not Found
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid skin contact (see Section V above).
COMMENTS
Sources searched but no information found:
Weast 1979
Hawley 1981
DASE 1980
Merck 1983
Doull 1980
Encyc Occupat Health and Safety 1983
Student 1981
Weiss 1980
Clayton and Clayton 1981-82
Verschueren 1983
NIOSH/OSHA 1978
ACGIH 1983
-------
CAS Registry Number: 109-61-5
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PROPYL CHLOROFORMATE
CAS Registry Number: 109-61-5
Synonyms: N-Propyl Chloroformate; Carbonochloridic Acid, Propyl Ester;
Formic Acid,°Chloro-, Propyl Ester; Propyl Chlorocarbonate
Chemical Formula: C.H_C10_
47 2
Molecular Weight: 122.56
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (mouse)
650 mg/kg; LD5Q dermal (mouse) 10 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 237-241°F, 114-116°C (*Merck 1976)
Specific Gravity (H20=l): 1.090 at 20° (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): 4.2 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (Sax 1984, p. 2307)
Appearance and Odor: Colorless liquid (*Merck 1976)
-------
CAS Registry Number: 109-61-5
Page 2 of 3
PROPYL CHLOROFORMATE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -58°F, -50°C (*Clayton and Clayton 1981-82)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray and foam. Move container from fire area if you can do so
without risk. Dike fire control water for later disposal; do not scatter
the material. Spray cooling water on containers that are exposed to
flames until after fire is out. Withdraw immediately in case of rising
sound from venting safety device or any discoloration of tank due to fire
(DOT 1984, Guide 28).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Wear positive pressure breathing apparatus and special protective
clothing. Isolate for 1/2 mile in all directions if tank car or truck is
involved in fire (DOT 1984, Guide 28).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of chlorine containing compounds (Sax 1984, p. 2307).
Propyl chloroformate is a flammable/combustible material; it may be
ignited by heat, sparks or flames. Vapors may travel to a source of
ignition and flash back. Container may explode in heat or fire. Vapor
explosion and poison hazard indoors, outdoors or in sewers. Runoff to
sewer may create fire or explosion hazard. Runoff from fire control or
dilution water may cause pollution (DOT 1984, Guide 28).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Clayton and Clayton 1981-82)
Stable:
Conditions to Avoid: Decomposes spontaneously to form hydrochloric
acid and other products. Avoid moist air ("Clayton and Clayton
1981-82).
Incompatibility (Materials to Avoid): Gradually decomposes by water
and alcohol (Merck 1983, p. 1130)
Hazardous Decomposition or Byproducts: Decomposes and forms
hydrochloric acid (-Clayton and Clayton 1981-82).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 109-61-5
Page 3 of 3
PROPYL CHLOROFORMATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 2307)
Skin: Yes (DOT 1984, Guide 28)
Ingestion: Yes (DOT 1984, Guide 28)
Health Hazards (Acute, Delayed, and Chronic): Strongly irritating to
eyes and mucous membranes ("Clayton and Clayton 1981-82). Poisonous; may
be fatal if inhaled, swallowed or absorbed through skin (DOT 1984, Guide
28).
Signs and Symptoms of Exposure: Contact may cause burns to skin and
eyes (DOT 1984, Guide 28). Vapors strongly irritating to eyes and mucous
membranes (Merck 1983, p. 1130).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 28).
SECTION VI -- USE INFORMATION
Not Found
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Wear positive pressure breathing apparatus
and special protective clothing. Spill or leak: shut off ignition
sources; no flares, smoking or flames in hazard area. Do not touch
spilled material; stop leak if you can do so without risk. Use water
spray to reduce vapors. Small spills: absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 28).
-------
CAS Registry Number: 109-77-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- MALONONITRILE
CAS Registry Number: 109-77-3
Synonyms: Cyanoacetonitrile; Dicyanomethane; Malonic Acid Dinitrile;
Malonic Dinitrile; Malonicdinitrile; Malonodinitrile; Methane, Dicyano-;
Methylene Cyanide; Methylenedinitrile; Propanedinitrile; USAF A-4600
Chemical Formula: C3H2N2
Molecular Weight: 66.07
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not found
ACGIH TLV: Not found
IDLH: Not found
Other Limits Recommended: Occupational exposure to nitriles
recommended standard -- air: TWA 8 mg/m3. Toxicity information:
LD5Q oral (mouse) 19 mg/kg (*NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 424-426°F, 218-219°C (*Weast 1979)
Specific Gravity (H20=l): 1.1910 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: 90°F, 32°C (*Weast 1979)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 13 g/100 ml (*Patty 1963)
Appearance and Odor: Material is a colorless to white solid (*Sax
1979, *Patty 1963)
-------
CAS Registry Number: 109-77-3
Page 2 of 3
MALONONITRILE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 266°F, 130°C (OC) (*Sax 1979)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Dry chemical, carbon dioxide, water spray, fog,
or foam (DOT 1984, Guide 53).
Special Fire Fighting Procedures: Move container from fire area if you
can do it without risk. Wear positive pressure breathing apparatus and
special protective clothing (DOT 1984, Guide 53).
Unusual Fire and Explosion Hazards: When heated to decomposition,
malononitrile emits highly toxic fumes (*Sax 1979). May polymerize
violently on prolonged heating (*Bretherick 1979).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Heat
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Highly toxic fumes (cyanide)
when heated (*Sax 1979).
Hazardous Polymerization: May Occur: Yes (-Bretherick 1979)
May Not Occur:
Conditions to Avoid: Prolonged heating at 130°C or contact with
strong bases at lower temperatures (*Bretherick 1979).
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Patty 1963)
Skin: Yes (*Patty 1963)
Ingestion: Yes (*Rumack 1975 to Present)
-------
CAS Registry Number: 109-77-3
Page 3 of 3
MALONONITRILE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Metabolized by body to
cyanide and thiocyanate; effects of inhalation of toxic fumes will be
related to cyanide (*Rumack 1975 to'Present, ""Patty 1963). Causes brain
and heart damage related to lack of cellular oxygen (*Doull 1980). It is
classified as extremely toxic. Probable oral lethal dose for humans is
5-50 mg/kg, or between 7 drops and 1 teaspoonful, for a 70 kg (150 Ib.)
person (Gosselin 1984, p. 11-215).
Signs and Symptoms of Exposure: See cyanides (*Rumack 1975 to
Present). Symptoms of cyanide poisoning include rapid and irregular
breathing, anxiety, confusion, odor of bitter almonds (on breath or
vomitus), nausea, vomiting (if oral exposure), irregular heart beat, a
feeling of tightness in the chest, bright pink coloration of the skin,
unconsciousness followed by convulsions, involuntary urination and
defecation, paralysis and respiratory arrest (heart will beat after
breathing stops) (Gosselin 1984, p. III-126-127).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: See cyanides. Get emergency
medical treatment immediately. If the victim stops breathing before
emergency medical treatment is available, give artificial respiration or
oxygen, but avoid mouth to mouth respiration; also avoid contact with
contaminated skin. If there is exposure through skin contact, wash
immediately with soap and water. Exposed eyes should be flushed with
copious amounts of water for at least 15 minutes (*Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
It is used in organic synthesis, and as a leaching agent for gold (*Hawley
1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
When handling material, wear self-contained positive pressure breathing
apparatus and special protective clothing. Take up small spills with sand
or other noncombustible material. Dike far ahead of large spills for
later disposal. Do not touch spilled material; stop leak if you can do so
without risk. Stay upwind and out of low areas. Isolate area and deny
entry (DOT 1984, Guide 53).
-------
CAS Registry Number: 110-00-9
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- FURAN
CAS Registry Number: 110-00-9
Synonyms: l,4-Epoxy-l,3-Butadiene; Divinylene Oxide; Furfuran; NCI-C56202;
Oxacyclopentadiene; Oxole; TetroLe; Axole
Chemical Formula: C.H.O
4 4
Molecular Weight: 68.08
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Exposure concentration limit: 10 ppra ("Sax
1979). Toxicity information: LC inhalation (mouse) 0.12 mg/liter/1
hour (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 90°F, 32°C at 758 mmHg (*Merck 1983)
Specific Gravity (H.0=l): 0.9371 at 19.4°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: -123°F, -86°C (*Sax 1979)
Vapor Density (AIR=1): 2.3 (*NFPA 1978)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Merck 1976); 10 g/liter at 25°C
(Verschueren 1983, p. 686)
-------
CAS Registry Number: 110-00-9
Page 2 of 4
FURAN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Clear colorless liquid turning brown upon
standing (Hawley 1981, p. 483)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Less than 32°F, less than 0°C (CC)
(*NFPA 1978)
Flammable Limits:
LEL: 2.3% (*NFPA 1978)
UEL: 14.3% (*NFPA 1978)
Extinguishing Methods: Water may be ineffective (*NFPA 1978). Small
fires: dry chemical, carbon dioxide, water spray, or alcohol foam. Large
fires: water spray, fog, or alcohol foam (DOT 1984, Guide 26).
Special Fire Fighting Procedures: Move container from fire area if
this can be accomplished without risk. Spray cooling water on containers
that are exposed to flames until well after fire is out. For massive
fires in cargo area, use unmanned hose holder or monitor nozzles; if this
is impossible withdraw from area and let fire burn. Withdraw immediately
in case of rising sound from venting safety device or any discoloration of
tank due to fire. Isolate for 1/2 mile in all directions if a tank car or
truck is involved (DOT 1984, Guide 26).
Unusual Fire and Explosion Hazards: Very dangerous, upon exposure to
heat or flame. It may form unstable peroxides on exposure to air.
Contact with acids can initiate a violent, heat producing reaction (*Sax
1979).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Sax 1979)
Stable:
Conditions to Avoid: Upon standing in air, it may form unstable
peroxides (*Sax 1979).
Incompatibility (Materials to Avoid): Acids, oxidizing agents (*Sax
1979).
Hazardous Decomposition or Byproducts: Formation of unstable peroxides
upon standing in air (*Sax 1979).
-------
CAS Registry Number: 110-00-9
Page 3 of 4
FURAN
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V. -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (''•Sax 1975)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): The vapors are narcotic
(Merck 1983, p. 613). Acute exposure to furan by inhalation may involve
both reversible and irreversible changes. Acute exposure by ingestion or
skin absorption, as well as chronic exposure, are associated with high
toxicity (*Sax 1975).
Signs and Symptoms of Exposure: Vapors are a central nervous system
depressant (*Merck 1976). Irritation and burning eyes and skin,
dizziness, suffocation (DOT 1984, Guide 26).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; if not
breathing give artificial respiration or if breathing is difficult give
oxygen. In case of contact with the material, immediately flush eyes with
running water for at least 15 minutes. Wash skin with soap and water.
Remove and isolate contaminated clothing and shoes at the site (DOT 1984,
Guide 26).
SECTION VI -- USE INFORMATION
Chemical intermediate for tetrahydrofuran (*SRI); formation of lacquers,
solvent for resins (^Browning 1965); organic synthesis, especially for
pyrrole, thiophene (*Hawley 1981).
-------
CAS Registry Number: 110-00-9
Page 4 of 4
FURAN
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Avoid
breathing vapors; wear a positive pressure self-contained breathing
apparatus. Keep upwind. Wear boots, protective gloves and goggles. Do
not handle broken packages without protective equipment. Wash away any
material which may have contacted the body with copious amounts of water
or soap and water. Shut off ignition sources; no flares, smoking, or
flames in hazard area. Stop leak if you can do so without risk. Use
water spray to reduce vapors. Small spills: absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal
(Student 1984, p. 259; DOT 1984, Guide 26). The exposure concentration
limit of 10 ppm together with the low boiling point of furan requires that
adequate ventilation be provided in areas handling this chemical. Contact
with liquid must be avoided since this chemical can be absorbed through
the skin. Thorough washing with soap and water followed by prolonged
rinsing should be done immediately after accidental contact (Sax 1984, p.
1462).
-------
CAS Registry Number: 110-57-6
Page 1 of 3
ENI CPHHIHCAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- fiflit$-1,4-DICHLOROBUTENE
CAS Registry Number: 110-57-6
Synonyms: l,4-Dichloro-tr«ns-2-Butene; l,4-Dichloro-2-Butene;
1,4-Dichlorobutene; 1,4-Di«fclor
-------
CAS Registry Number: 110-57-6
Page 2 of 3
TRANS-1,4-DICHLOROBUTENE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: 1.5% (Weiss 1980, p. 330)
DEL: 4% (Weiss 1980, p. 330)
Extinguishing Methods: For small fires, use dry chemical, carbon
dioxide, spray or foam. For large fires, use water spray, fog, or foam
(DOT 1984, Guide 29).
Special Fire Fighting Procedures: Wear positive pressure breathing
apparatus and full protective clothing. Move containers from fire area if
you can do so without risk. Spray containers with cooling water until
well after fire is out. Isolate for one-half mile in all directions if
tank car or truck is involved in a fire (DOT 1984, Guide 29).
Unusual Fire and Explosion Hazards: The material will burn, though it
may require some effort to ignite (Student 1981, p. 184). Fire produces
irritating and poisonous gases (DOT 1984, Guide 29). When heated to
decomposition, it emits toxic fumes of chlorine-containing compounds (Sax
1984, p. 583).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 322)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of chlorine-containing compounds (Sax 1984, p. 583).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*IARC 1972-85)
Skin: Yes (*Grant 1974)
Ingestion: Yes (*Rumack 1975 to Present)
-------
CAS Registry Number: 110-57-6
Page 3 of 3
TRANS-1,4-DICHLOROBUTENE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): (Non-Specific --
Dichlorobutene) Liquid and vapors from the material are highly corrosive
and may damage skin, eyes, lungs, and internal organs (*IARC 1972-85).
Signs and Symptoms of Exposure: Respiratory distress and burns to skin
and eyes (DOT 1984, Guide 29). Inhalation of vapor irritates nose and
throat. Contact with eyes causes intense irritation and tears. Contact
of1liquid with skin causes severe blistering. Ingestion causes severe
irritation of mouth and stomach (Weiss 1980, p. 322).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air. If not
breathing, give artificial respiration. If breathing is. difficult, give
oxygen. Remove and isolate contaminated clothing. In case of contact,
immediately flush skin and eyes with running water for 15 minutes. Keep
victim quiet and maintain normal body temperature (DOT 1984, Guide 29).
SECTION VI -- USE INFORMATION
It is a chemical intermediate for hexamethylenediamine and chloroprene
(-SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area. Stay upwind; keep out
of low areas. Wear positive pressure breathing apparatus. Shut off
ignition sources. Do not touch spilled material. Use water spray to
reduce vapors, but do not get water inside containers. For small spills,
absorb with sand or other non-combustible absorbent material. For large
spills, dike far ahead of spill for later disposal (DOT 1984, Guide 29).
-------
CAS Registry Number: 110-89-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- PIPERIDINE
CAS Registry Number: 110-89-4
Synonyms: Azacyclohexane; Cyclopentimine; Cypentil; Hexahydropyridine;
Hexazane; Pentamethyleneimine; Pentamethylenimine; Pyridine, Hexahydro-
Chemical Formula: crHnN
Molecular Weight: 85.15
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat)
1985)
(rat) 13.9 mg/liter/4 hours; LD5Q oral (mammal) 22.4 mg/kg (*NIOSH/RTECS
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 223°F, 106°C (*Merck 1976)
Specific Gravity (H 0=1): 0.8622 at 20°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 40 at 29.2°C ('''Patty 1963)
Melting Point: 19°F, -7°C (*Merck 1976), 16°F, -9°C (Weast 1980, p.
C-441)
Vapor Density (AIR=1): 3.0 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in all proportions (*Weast 1979)
-------
CAS Registry Number: 110-89-4
Page 2 of 4
PIPERIDINE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Piperidine is a clear colorless liquid with an
amine-like odor (Sax 1984, p. 2236). A pepper-like odor has also been
reported (Hawley 1981, p. 819).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 61°F (no method given) (*Patty 1963);
37.4°F (no method given) (Sax 1984, p. 2236)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray, or alcohol foam. Large fires: water spray, fog, or alcohol
foam. Move container from fire area if you can do it without risk. Do
not get water inside container. Cool containers that are exposed to
flames with water from the side until well after fire is out. Withdraw
immediately in case of rising sound from venting safety device or any
discoloration of tank due to fire (DOT 1984, Guide 29).
Special Fire Fighting Procedures: Keep unnecesary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low area. Wear
self-contained (positive pressure if available) breathing apparatus and
full protective clothing. Isolate for 1/2 mile in all directions if tank
car or truck is involved in fire (DOT 1984, Guide 29).
Unusual Fire and Explosion Hazards: Piperidine evolves explosive
concentrations of vapor at normal room temperatures (*Encyc Occupat Health
and Safety 1971). When heated to decomposition, it emits highly toxic
fumes of nitrogen oxides (*Sax 1979). Dangerous, when exposed to heat,
flame, or oxidizers (Sax 1984, p. 2236).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: It evolves explosive concentrations of vapor
at normal room temperatures (*Encyc Occupat Health and Safety 1971).
Keep away from igniting sources and heat (*NFPA 1978).
-------
CAS Registry Number: 110-89-4
Page 3 of 4
PIPERIDINE
SECTION IV -- REACTIVITY DATA Continued)
Incompatibility (Materials to Avoid): Avoid 1-Perchlorylpiperidine
(Sax 1984, p. 2236) and oxidizing materials (-Sax 1979). Piperidine is a
reactive compound and forms complexes with the salts of heavy metals
(Merck 1983, p. 1077).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes of nitrogen oxides (Sax 1984, p. 2236).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Encyc Occupat Health and
Safety 1971)
Skin: Yes (*Encyc Occupat Health and Safety 1971)
Ingestion: Yes (*Encyc Occupat Health and
Safety 1971)
Health Hazards (Acute, Delayed, and Chronic): Strong local irritant
and may cause permanent injury after short exposure to small amounts.
Ingestion may involve both irreversible and reversible changes (*Sax
1975). 30 to 60 mg/kg may cause symptoms in humans (Clayton and Clayton
1981, pp. 2689-90).
Signs and Symptoms of Exposure: Symptoms upon oral administration
include weakness, nausea, vomiting, salivation, labored respiration,
muscular paralysis, and asphyxiation (Clayton and Clayton 1981, pp.
2689-90). Redness, pain, and burns occur upon contact with skin.
Corrosive effects seen when contact is made with the eyes. Sore throat,
coughing, labored breathing, and dizziness occur after inhalation (DASE
1980, p. 757).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Keep victim quiet and maintain normal body temperature (DOT
1984, Guide 29).
-------
CAS Registry Number: 110-89-4
Page 4 of 4
PIPERIDINE
SECTION VI -- USE INFORMATION
Solvent and intermediate; curing agent for rubber and epoxy resins;
catalyst for condensation reactions; ingredient in oils and fuels;
complexing agent (Hawley 1981, p. 818); manufacture of local anesthetics,
analgesics, Pharmaceuticals, wetting agents, and germicides (*Encyc
Occupat Health and Safety 1971); synthetic flavoring (-Fenaroli 1975).
Not registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985).
SECTION Vll -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation (see Section V). Shut off ignition sources; no flares,
smoking, or flames in hazard area. Do not touch spilled material; stop
leak if you can do so without risk. Wear positive pressure breathing
apparatus and full protective clothing. Use water spray to reduce vapors;
do not get water inside container. Small spills: absorb with sand or
other noncombustible absorbent material and place into containers for
later disposal. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 29).
-------
CAS Registry Number: 111-34-2
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- BUTYL VINYL ETHER
CAS Registry Number: 111-34-2
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, page 263):
Butoxyethene; Butane, l-(Ethenyloxy)-; Vinyl Butyl Ether; Ether, Butyl Vinyl;
Vinyl n-Butyl Ether
Chemical Formula: C,H100
o iz
Molecular Weight: 100.18
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(mouse) 0.062 mg/liter/2 hours (^NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 201°F, 94.1°C (Hawley 1981, p. 1084)
Specific Gravity (H20=l): 0.7803 at 20°C (Hawley 1981, p. 1084)
Vapor Pressure (mmHg): Not Found
Melting Point: -171°F, -113°C (Hawley 1981, p. 1084)
Vapor Density (AIR=1): 3.45 (Sax 1984, p. 2727)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (Hawley 1981, p. 1084)
Appearance and Odor: Liquid (Hawley 1981, p. 1084)
-------
CAS Registry Number: 111-34-2
Page 2 of 3
BUTYL VINYL ETHER
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 15°F, -9.4°C (OC) (Hawley 1981, p. 1084)
Flammable Limits: Flammable liquid (Hawley 1981, p. 1084)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Dangerous fire risk (Hawley 1981, p. 1084).
Small fires: dry chemical, carbon dioxide, water spray, or alcohol foam.
Large fires: water spray, fog, or alcohol foam. Move container from fire
area if you can do so without risk. Spray cooling water on containers
that are exposed to flames until well after fire is out. For massive fire
in cargo area, use unmanned hose holder and monitor nozzles; if this is
impossible, withdraw from area and let fire burn. Withdraw immediately in
case of rising sound from venting safety device or any discoloration of
tank due to fire (DOT 1984, Guide 26).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Wear self-contained (positive pressure if available) breathing apparatus
and full protective clothing. Isolate for 1/2 mile in all directions if
tank car or truck is involved in fire (DOT 1984, Guide 26).
Unusual Fire and Explosion Hazards: Flammable/combustible material;
may be ignited by heat, sparks or flames. Vapors may travel to a source
of ignition and flash back. Container may explode in heat of fire. Vapor
explosion hazard indoors, outdoors, or in sewers. Runoff to sewer may
create fire or explosion hazard (DOT 1984, Guide 26).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Heat or flame (Sax 1984, p. 2727)
Incompatibility (Materials to Avoid): Oxidizing materials (Sax 1984,
p. 2727).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 111-34-2
Page 3 of 3
BUTYL VINYL ETHER
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (DOT 1984, Guide 26)
Skin: Yes (Sax 1984, p. 2727)
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): May be poisonous if
inhaled or absorbed through skin (DOT 1984, Guide 26).
Signs and Symptoms of Exposure: Vapors may cause dizziness or
suffocation. Contact may irritate or burn skin and eyes (DOT 1984, Guide
26).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush eyes with running water for at least 15 minutes. Wash
skin with soap and water. Remove and isolate contaminated clothing and
shoes at the site (DOT 1984, Guide 26).
SECTION VI -- USE INFORMATION
Synthesis; copolymerization (Hawley 1981, p. 1084)
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material and avoid breathing vapors (see Section V
above). Stay upwind. Wear self-contained (positive pressure if
available) breathing apparatus and full protective clothing. Shut off
ignition sources; no flares, smoking, or flames in hazard area. Stop leak
if you can do so without risk. Use water spray to reduce vapors. Small
spills: absorb with sand or other noncombustible absorbent material and
place into containers for later disposal. Large spills: dike far ahead
of spill for later disposal (DOT 1984, Guide 26).
COMMENTS:
Sources searched but no information found:
Weast 1979
Merck 1983
NFPA 1984
Student 1981
Weiss 1980
Doull 1980
Gosselin 1984
-------
CAS Registry Number: 111-44-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DICHLOROETHYL ETHER
CAS Registry Number: 111-44-4
Synonyms: «Bis(2-Chloroethyl) Ether; 1,1*-Oxybis(2-Chloroethane);
1,5-Dichloro-3-Oxapentane; l-Chloro-2-(beta-Chloroethoxy)Ethane;
2,2'-Dichloroethyl Ether; 2,2*-Dichlorodiethyl Ether; 2,2'-Dichlorethyl Ether;
2-Chloroethyl Ether; beta,beta1-Dichlorodiethyl Ether; beta,beta'-Dichloroethyl
Ether; beta.beta-Dichlorodiethyl Ether; bis(2-Chloroethyl)Ether;
bis(beta-Chloroethyl) Ether; bis(Chloro-2-Ethyl) Oxide; Chlorex; Chloroethyl
Ether; Clorex; DCEE; Di(2-Chloroethyl) Ether; Di(beta-Chloroethyl)Ether;
Dichloroether; Dichloroethyl Oxide; ENT 4,504; Ether, bis(2-Chloroethyl);
sym-Dichloroethyl Ether
Chemical Formula: C.H0C100
'f O 2.
Molecular Weight: 143.02
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Ceiling concentration: 15 ppm (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 5 ppm (30 mg/m3); STEL 10 ppm (60 mg/m3) (skin)
(-ACGIH 1982)
IDLH: 250 ppm (NIOSH/OSHA 1978, p. 82)
Other Limits Recommended: Maximum air concentration (USSR) 2 mg/m3
(Encyc Occupat Health and Safety 1983, p. 122)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 352°F, 178°C (*Merck 1976)
Specific Gravity (H20=l): 1.22 at 20°/20°C (*Merck 1976)
Vapor Pressure (mmHg): 0.7 at 20°C (-Sax 1979)
Melting Point: -58°F, -50°C (Merck 1983, p. 445)
-------
CAS Registry Number: 111-44-4
Page 2 of 4
DICHLOROETHYL ETHER
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Density (AIR=1): 4.93 (-Browning 1965)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble in hot water (-Weast 1979)
Appearance and Odor: Colorless, clear liquid with pungent (*Merck
1976) or nauseating (-ACGIH 1980) or sweet, pleasant odor (-CHRIS 1978).
At the vapor concentration necessary to cause respiratory tract damage,
the odor is easily detectable and usually intolerable (*Patty 1963)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 180°F, 82°C (OC); 131°F, 55°C (CC) (Weiss
1980, p. 325)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Use water, foam, mist, fog, spray, or dry
chemical (*Sax 1979). Use water in flooding quantities as fog (Student
1981, p. 185). Small fires: dry chemical, carbon dioxide, water spray,
or foam. Large fires: water spray, fog, or foam. Move container from
fire area if you can do so without risk. Spray cooling water on
containers that are exposed to flames until well after fire is out. Fight
fire from maximum distance. Dike fire control water for later disposal;
do not scatter the material (DOT 1984, Guide 57).
Special Fire Fighting Procedures: Wear full protective clothing (*NFPA
1978). Do not extinguish fire unless flow can be stopped. Cool all
affected containers with flooding quantities of water. Apply water from
as far a distance as possible (Student 1981, p. 185).
Unusual Fire and Explosion Hazards: May form phosgene or hydrogen
chloride in fires ("CHRIS 1978). There is danger of explosion when ethers
are heated or exposed to flames or sparks. Ethers tend to form peroxides;
when ethers containing peroxides are heated, they can detonate (*Sax
1979). May be ignited by heat, sparks, or flames. Container may explode
in heat of fire. Vapor explosion and poison hazard indoors, outdoors or
in sewers (DOT 1984, Guide 57).
-------
CAS Registry Number: 111-44-4
Page 3 of 4
DICHLOROETHYL ETHER
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 325)
Conditions to Avoid: Ethers tend to form peroxides upon standing.
Heating peroxide-containing ethers can cause detonation (''"Sax 1979).
Incompatibility (Materials to Avoid): Reacts vigorously with oleum and
chlorosulfonic acid ("'Sax 1979) .
Hazardous Decomposition or Byproducts: Decomposes in the presence of
moisture to form hydrochloric acid (*Martin 1974). Emits toxic fumes when
heated to decomposition ("Sax 1979); may form phosgene or hydrochloric
acid in fires (*CHRIS 1978).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Browning 1965)
Skin: Yes ("Encyc Occupat Health and Safety 1971)
Ingestion: Yes (-Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): This material is very
toxic; the probable oral lethal dose is 50-500 mg/kg, or between 1
teaspoonful and 1 ounce for a 150 pound person ("Gosselin 1976) . It can
be a central nervous system depressant in high concentrations. It is
extremely irritating to the eyes, nose, and respiratory passages
(''•Browning 1965). It can penetrate the skin to cause serious and even
fatal poisoning (*Encyc Occupat Health and Safety 1971). Poisonous; may
be fatal if inhaled, swallowed or absorbed through skin (DOT 1984, Guide
57).
Signs and Symptoms of Exposure: At concentrations above 500 ppm,
coughing, retching, and vomiting may occur (*Browning 1965), as well as
profuse tearing ("Grant 1974). There can be irritation at lower
concentrations (^Browning 1965). Contact may cause burns to skin and eyes
(DOT 1984, Guide 57).
Medical Conditions Generally Aggravated by Exposure: Not Found
-------
CAS Registry Number: 111-44-4
Page 4 of 4
DICHLOROETHYL ETHER
SECTION V -- HEALTH HAZARD DATA (Continued)
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 57).
SECTION VI -- USE INFORMATION
This material is used as a chemical intermediate for organic compounds and
polymers ("SRI), in the treatment of textiles (*Merck 1976) and in dry
cleaning (-Hawley 1977), as a pesticide (*NRC 1977; *Farm Chemicals
Handbook 1977), as an anesthetic (*IARC 1972-1985), and for various other
applications.
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Remove all ignition sources. Ventilate area of spill or leak. "Do not
allow this material to enter a confined space, such as a sewer, because of
the possibility of an explosion. Absorb spills in vermiculite, dry sand,
earth, or similar material ("NIOSH/OSHA 1981). Keep material out of water
sources and sewers. Build dikes to contain flow as necessary. Use water
spray to knock down vapors (Student 1981, p. 185). Spill or leak: shut
off ignition sources; no flares, smoking or flames in hazard area. Do not
touch spilled material; stop leak if you can do so without risk. Use
water spray to reduce vapors. Small spills: absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal.
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Wear positive pressure breathing apparatus and special protective
clothing (DOT 1984, Guide 57).
-------
CAS Registry Number: 111-69-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- ADIPONITRILE
CAS Registry Number: 111-69-3
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 287): Adipic Acid
Dinitrile; Adipic Acid Nitrile; Adipodinitrile; 1,4-Dicyanobutane;
Hexanedinitrile; Hexanedioic Acid, Dinitrile; Tetramethylene Cyanide
Chemical Formula: C,H0N0
D O Z
Molecular Weight: 108.16
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Occupational exposure to nitriles,
recommended standard air: TWA 18 mg/m3. Toxicity information: LC,.-
inhalation (rat) 1.7 mg/liter/4 hours (NIOSH/RTECS 1983, Volume 1, p. 287)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 563°F, 295°C (Sax 1984, p. 143)
Specific Gravity (H20=l): 0.965 at 20°/4°C (Sax 1984, p. 143)
Vapor Pressure (mmHg): Not Found
Melting Point: 36.1°F, 2.3°C (Sax 1984, p. 143)
Vapor Density (AIR=1): 3.73 (Sax 1984, p. 143)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (Hawley 1981, p. 21)
Appearance and Odor: Water white liquid, practically odorless (Sax
1984, p. 143).
-------
CAS Registry Number: 111-69-3
Page 2 of 3
ADIPONITRILE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 199.4°F (OC) (Sax 1984.,,,p. 143)
Flammable Limits:
LEL: 1.0% at 200°C (Weiss 1980, p. 60)
UEL: Not Found
Extinguishing Methods: Dry chemical, carbon dioxide, water spray, fog
or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Wear chemical protective suit with
self-contained breathing apparatus. Cool exposed containers with water
(Weiss 1980, p. 60).
Unusual Fire and Explosion Hazards: Combustion products may contain
hydrocyanic acid (HCN) (Sax 1984, p. 143). Vapor may explode if ignited
in an enclosed area (Weiss 1980, p. 60).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 60)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Oxidizing material (Sax 1984, p.
143).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes (Sax 1984, p. 143).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 60)
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 143)
Skin: Yes (DOT 1984, Guide 55)
Ingestion: Yes (Sax 1984, p. 143)
Health Hazards (Acute, Delayed, and Chronic): This material is toxic
by ingestion and inhalation (Hawley 1981, p. 21). It produces
disturbances of the respiration and circulation, irritation of the stomach
and intestine, and loss of weight (Sax 1984, p. 143). It is irritating to
skin and eyes (Weiss 1980, p. 60).
-------
CAS Registry Number: 111-69-3
Page 3 of 3
ADIPONITRILE
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Ingestion of a few milliliters may
cause weakness, mental confusion, vomiting, rapid respiration, fast heart-
beat, and convulsions. Exposure to vapor may cause headache and
convulsions (Weiss 1980, p. 60).
Medical Conditions Generally Aggravated by Exposure:
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
This material is used as an intermediate in the manufacture of nylon and
in organic synthesis (Hawley 1981, p. 21).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Wear positive pressure breathing apparatus and special protective
clothing. Remove and isolate contaminated clothing at the site. Do not
touch spilled material; stop leak if you can do it without risk. Use
water spray to reduce vapors. Small spills: take up with sand or other
non-combustible absorbent materal and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 55).
-------
CAS Registry Number: 115-21-9
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY - TRICHLOROETHYLSILANE
CAS Registry Number: 115-21-9
Synonyms: Silane, Ethyltrichloro-; Ethyl Silicon Trichloride;
Ethyltrichlorosilane; Silane, Ethyl(Trichloro)-; Silane, Trichloroethyl-;
Silicane, Trichloroethyl-; Trichloroethylsilicane; Trichloroethylsilicon
Chemical Formula: C2H5Cl3Si
Molecular Weight: 163.51
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(rat) 3.34 mg/liter/4 hours (-NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 208°F, 97.9°C (--Weast 1979)
Specific Gravity (H20=l): 1.2381 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: -158°F, -105.6°C ('''Weast 1979)
Vapor Density (AIR=1): 5.6 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Decomposes in water (*Weast 1979)
Appearance and Odor: Trichloroethylsilane is a colorless liquid
(*Hawley 1981).
-------
CAS Registry Number: 115-21-9
Page 2 of 3
TRICHLOROETHYLSILANE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 72°F, 22.2°C (OC) (*Sax 1979)
Flammable Limits: May be ignited under almost all normal temperature
conditions (*NFPA 1978)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Caution: reacts with water to produce heat
and toxic and corrosive fumes -- see Section IV below.) Use dry chemical,
alcohol foam, or carbon dioxide; water may be ineffective, but water
should be used to keep fire-exposed containers cool. If a leak or spill
has not ignited, use water spray to disperse the vapors and to protect men
attempting to stop a leak. Water spray may be used to flush spills away
from exposure and to dilute spills to non-flammable mixtures (*NFPA 1978).
Special Fire Fighting Procedures: Enter fire areas with extreme care.
Full protective clothing must be worn including self-contained breathing
apparatus, rubber gloves, boots, and bands around arms, legs, and waist.
No skin surface should be exposed (*NFPA 1978). Isolate for 1/2 mile in
all directions if tank car or truck is involved in fire (*DOT 1984).
Unusual Fire and Explosion Hazards: Trichloroethylsilane may form
explosive mixtures with air (*Hawley 1981). Its vapors are heavier than
air and may travel a considerable distance to a source of ignition and
flash back (»NFPA 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Sax 1979)
Stable:
Conditions to Avoid: Decomposing heat (*Sax 1979)
Incompatibility (Materials to Avoid): Will react with water or steam
to produce heat and toxic and corrosive fumes. Will react vigorously with
oxidizing materials (*Sax 1979).
Hazardous Decomposition or Byproducts: Toxic and corrosive fumes
including phosgene when heated to decomposition (*Sax 1979); hydrochloric
acid in presence of water (*Hawley 1981).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 115-21-9
Page 3 of 3
TRiCHLOROETHYLSILANE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Vapor and liquid cause
burns. Do not inhale or expose eyes to vapor. Vapor may damage eyes even
if not immediately painful (NFPA 1984, pp. 49-89).
Signs and Symptoms of Exposure: By mouth (oral) -- corrosion of
membranes (grayish-white to black areas of discoloration) of mouth,
throat, and esophagus; abdominal pain, difficulty in swallowing; nausea
and vomiting; intense thirst; shock with cold skin, rapid pulse, shallow
respiration leading to death. By inhalation -- severe difficulty in
breathing with swelling of larynx (throat); skin burns on exposed skin
(*Rumack 1975 to Present); eyes -- irritation, pain and tearing (*Grant
1974).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at site, being careful not to get corrosive material on
your skin. In case of skin contact, immediately flush skin or eyes with
running water for at least 15 minutes (*DOT 1984). If chemical has been
taken by mouth (oral), do not induce vomiting. Give victim copious
amounts of water to rinse out mouth and esophagus and dilute stomach by
having victim drink 1-2 large glassfuls of water or milk (*Rumack 1975 to
Present).
SECTION VI -- USE INFORMATION
Chemical intermediate for silicones ("SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors or contact with eyes or skin (see Section V
above). Wear self-contained (positive pressure if available) breathing
apparatus and full protective clothing. Shut off ignition sources; no
flares, flames, or smoking. Do not touch spilled material; stop leak if
you can do it without risk. Use water spray to reduce vapor but do not
get water inside container. Small spills: take up with sand or other
noncombustible absorbent material and containerize. Large spills: dike
ahead of spill for later disposal (*DOT 1984).
-------
CAS Registry Number: 115-26-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -•- DIMEFOX
CAS Registry Number: 115-26-4
Synonyms: Phosphorodiamidic Fluoride, Tetramethyl-; BFP; BFPO;
bis(Dimethylamido)Phosphoryl Fluoride; N,N,N',N'- Tetramethylphosphorodiamidic
Fluoride; Dimefox; Tetramethylphosphorodiamidic Fluoride;
bis(Dimethylamido)Fluorophosphate; bis(Dimethylamino)Fluorophosphate;
Bisdimethylaminofluorophosphine Oxide; CR 409; DIFO; DMF; Fluophosphoric acid
Di(Dimethylamide); Hanane; Pestox 14; Pestox IV; Pestox XIV; Phosphine Oxide,
bis(Dimethylamino)Fluoro-; Phosphorodiamidic Fluoride, Tetramethyl-; S-14;
T-2002; Terra-sytam; Terrasytum; Tetrasytam; Tetramethyldiamidophosphoric
Fluoride; TL 792; Wacker S 14/10
Chemical Formula: C.H FN-OP
Molecular Weight: 154.13
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LDcn oral (rat) 1.0
mg/kg (-'-NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 187°F, 86°C at 15 mmHg (*Merck 1976)
Specific Gravity (H 0=1): 1.115 at 20°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 0.36 at 25°C (-Martin 1974)
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 115-26-4
Page 2 of 4
DIMEFOX
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Freely soluble (*Merck 1976)
Appearance and Odor: Colorless liquid (*Martin 1974) with a fishy odor
(-Merck 1976)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Insecticide, Liquid,
Poisonous, n.o.s.) Extinguish with dry chemical, carbon dioxide, water
spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Insecticide,
Liquid, Poisonous, n.o.s.) Stay upwind; keep out of low areas. Wear
positive pressure breathing apparatus and special protective clothing.
Ventilate closed spaces before entering them. Move container from fire
area if you can do so without risk. Dike fire control water for later
disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Highly toxic fumes are given off
upon decomposition with heat (*Sax 1975). (Non-Specific -- Insecticide,
Liquid, Poisonous, n.o.s.) Container may explode in heat of fire (DOT
1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-Sunshine 1969)
Conditions to Avoid: Decomposing heat ("Sax 1975); contact with
chlorine (^Sunshine 1969).
Incompatibility (Materials to Avoid): Decomposes rapidly in the
presence of chlorine. Oxidizes slowly in strong oxidizing agents
(^Sunshine 1969).
Hazardous Decomposition or Byproducts: Highly toxic fumes are given
off when material is heated to decomposition ("Sax 1975).
-------
CAS Registry Number: 115-26-4
Page 3 of 4
DIMEFOX
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION y -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Martin 1974)
Skin: Yes (-Rumack 1975 to Present)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): This material is
extremely toxic; the probable oral lethal dose (human) is 5-50 mg/kg, or 7
drops to 1 teaspoonful for a 150-Ib. person. Death may occur from
respiratory arrest (*Gosselin 1976). Hazards of vapor toxicity are high
(•-Martin 1974).
Signs and Symptoms of Exposure: Symptoms include headache, blurred
vision, nausea, cramps, difficulty in breathing, slurring of speech, and
excessive salivation (-'-Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Insecticide,
Liquid, Poisonous, n.o.s.) Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from the skin is of extreme
importance. Remove and isolate contaminated clothing and shoes at the
site. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
This material is used as an insecticide; it is neither produced nor used
in the U.S. (*SRI). Not registered as a pesticide in the U.S. (USEPA/
Pesticide Index 1985).
-------
CAS Registry Number: 115-26-4
Page 4 of 4
DIMEFOX
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation (see Section V above). (Non-Specific -- Insecticide,
Liquid, Poisonous, n.o.s.) Do not touch spilled material; stop leak if
you can do so without risk. Wear positive pressure breathing apparatus
and special protective clothing. Use water spray to reduce vapors. Small
spills: absorb with sand or other noncombustible absorbent material and
place into containers for later disposal. Large spills: dike far ahead
of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 115-29-7
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ENDOSULFAN
CAS Registry Number: 115-29-7
Synonyms: 5-Norbornene-2,3-Dimethanol, 1,4,5,6,7,7-Hexachloro-, Cyclic
Sulfite; 1,2,3,4,7,7-Hexachlorobicyclo[2.2.l]Hepten-5,6-Bioxymethylenesulfite;
1,2,3,4,7,7-Hexachlorobicyclo-[2.2.1]-Hepten-5,6-Bisoxymethylene Sulfite;
1,2,3,4,7,7-Hexachlorobicyclo[2.2.1]-2-Heptene-5,6-Bisoxymethylene Sulfite;
1,4,5,6,7,7-Hexachloro-5-Norbornene-2,3-Dimethanol Cyclic Sulfite;
1,4,5,6,7,7-Hexachloro-8,9,10-Trinorborn-5-en-2,3-ylenedimethyl Sulphite;
6,7,8,9,10,10-Hexachloro-1,5,5A,6,9,9A-Hexahydro-6,9-Methano-2,4,3-
Benzo[e]dioxathiepin-3-Oxide; 6,9-Methano-2,4,3-Benzodioxathiepin,
6,7,8,9,10,10-Hexachloro-1,5,5A,6,9,9A-Hexahydro-, 3-Oxide; alpha,
beta-1,2,3,4,7,7-Hexachlorobicyclo[2.2.1]-2-Heptene-5,6-Bisoxymethylene
Sulfite; AS 4314; Benzoepin; Beosit; BIO 5,462; Chlorthiepin; Crisulfan;
Cyclodan; Devisulphan; Endocel; Endosol; Endosulphan; Ensure; ENT 23,979; FMC
5462; Hexachlorohexahydromethano-2,4,3-Benzodioxathiepin-3-Oxide; Hildan; HOE
2,671; Insectophene; Kop-Thiodan; Malix; NCI C00566; NIA 5462; Niagara 5,462;
QMS 570; Sulfurous Acid, Cyclic Ester with 1,4,5,6,7,7-Hexachloro-5-
Norbornene-2,3-Dimethanol; Thifor; Thimul; Thiodan; Thiofor; Thiomul Thionex;
Thiosulfan; Thiosulfan Tionel; Thiotox [Insecticide]; Tionex; Tiovel; 6,7,8,9
10,10-Hexachloro-1,5,5a,6,9,9a-Hexahydro-6,9-Methano-2,4,3-Benzodioxathiepin-
3-Oxide
Chemical Formula: CnH,Cl,00S
y b o o
Molecular Weight: 406.95
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.1 mg/m3; STEL 0.3 mg/m3 (skin) (-ACGIH 1983)
IDLH: Not Found
Other Limits Recommended: Maximum air concentration (USSR) 0.1 mg/m3
(Encyc Occupat Health and Safety 1983, p. 1634). Toxicity information:
LC inhalation (rat) 0.08 mg/liter for 4 hours (*NIOSH/RTECS 1985).
-------
CAS Registry Number: 115-29-7
Page 2 of 4
ENDOSULFAN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Boiling Point: Not Found
Specific Gravity (H 0=1): 1.745 at 20°C (Farm Chemicals Handbook
1984, p. C-92)
Vapor Pressure (mmHg): 1 x 10"5 at 77°F, 25°C (^Worthing 1979)
Melting Point: a isomer 228.7°F, 109.2°C; 3 isomer 415.9°F,
213.3°C (Farm Chemicals Handbook 1984, p. C-92). Mixture 158-212°F,
70-100°C (Buchel 1983, p. 47; Hayes 1982, p. 252)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (Merck 1983, p. 516)
Appearance and Odor: Brown crystals (-Merck 1983); colorless crystals
(''"Spencer 1982); smells like sulfur dioxide (Hayes 1982, p. 252)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish fire using agent suitable for type
of surrounding fire. (Material itself does not burn or burns with
difficulty.) Use water in flooding quantities as fog. Use alcohol foam,
carbon dioxide or dry chemical (Student 1981, p. 220).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Container may explode in heat of
fire. Fire or run off from fire control water may release irritating or
poisonous gases (DOT 1984, Guide 55).
-------
CAS Registry Number: 115-29-7
Page 3 of 4
ENDOSULFAN
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (^White-Stevens 1971)
Conditions to Avoid: Slowly oxidizes in air (*White-Stevens
1971). Do not store at temperature below 20°F (Farm Chemicals
Handbook 1984, p. C-92).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Hawley 1984, p. 410)
Skin: Yes (Sax 1984, p. 377)
Ingestion: Yes (Sax 1984, p. 377)
Health Hazards (Acute, Delayed, and Chronic): It is very toxic. The
probable oral lethal dose is 50 to 500 rag/kg, or 1 teaspoonful to 1 ounce
for a 150 Ib. person ("Gosselin 1976).
Signs and Symptoms of Exposure: Can cause death. Symptoms include
gagging, vomiting, diarrhea, agitation, convulsions, foaming at the mouth,
dyspnea, apnea, bluing of skin and loss of consciousness (Hayes 1982, p.
253).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Speed in removing material
from skin is of extreme importance. Remove and isolate contaminated
clothing and shoes at the site. Keep victim quiet and maintain normal
body temperature. Effects may be delayed; keep victim under observation
(DOT 1984, Guide 55).
-------
CAS Registry Number: 115-29-7
Page 4 of 4
ENDOSULFAN
SECTION VI -- USE INFORMATION
This material is used as an insecticide for vegetable crops, fruits, and
nuts (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
In case of spills, stay upwind; stay out of low areas. Use water spray to
reduce vapors. Ventilate closed spaces before entering them. Wear
positive pressure breathing apparatus and special protective clothing. Do
not touch spilled material; stop leak if you can do it without risk.
Small spills: take up with sand or other noncombustible absorbent
material and place into containers for later disposal. Small dry spills:
with clean shovel place material into clean, dry container and cover; move
containers from spill area. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 115-90-2
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- FENSULFOTHION
CAS Registry Number: 115-90-2
Synonyms: Phosphorothioic Acid, 0,0-Diethyl 0-(p-(Methysulfinyl)Phenyl)
Ester; Agricur; B 25141; Bay 25141; Bayer 25141; Bayer S767; Chemagro 25141;
Daconit; Dasanit; Dazanit; Desanit; Diethyl p-Methylsulfinylphenyl
Thiophosphate; DMSP; ENT 24,945; 0,0-Diethyl 0-(4-(Methylsulfinyl)Phenyl)
Phosphorothioate; 0,0-Diethyl 0-(p-(Methylsulfinyl)Phenyl) Phosphorothioate;
Phenol, p-(Methylsulfinyl)-, 0-Ester With 0,0-Diethyl Phosphorothioate;
Phosphorothioic Acid, 0,0-Diethyl-0-(4-(Methylsulfinyl)Phenyl) Ester; S 767;
Terracur P; VUAGT; VUAGT 108; VUAGT 96
Chemical Formula: C,,H,_O.PS.
11 17 4 2
Molecular Weight: 308.35
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.1 mg/m3 (*ACGIH 1980)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD. oral (guinea
pig) 9 mg/kg (-'-NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 280-286°F, 138-141°C at 0.01 mmHg ('-Merck 1976)
Specific Gravity (H20=l): 1.202 (*Spencer 1973)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 115-90-2
Page 2 of 3
FENSULFOTHION
Solubility in Water: 1.54 g/liter (^Worthing 1979)
Appearance and Odor: Oily yellow liquid (^Worthing 1979); brown liquid
(*Spencer 1973)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphorus Pesticide,
Liquid, n.o.s.) Extinguish with dry chemical, carbon dioxide, water
spray, fog or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) Wear positive pressure breathing apparatus and
special protective clothing. Move container from fire area. Fight fire
from maximum distance. Dike fire control water for later disposal; do not
scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) This material may burn but may not ignite
readily. Containers may. explode in heat of fire (DOT 1984, Guide 55).
When heated highly toxic fumes of phosphorus and sulfur oxides are emitted
(*Sax 1979).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Menzie 1969)
Conditions to Avoid: Hydrolyzes in alkali, isomerizes in air
(-Menzie 1969).
Incompatibility (Materials to Avoid): Incompatible with alkali
chemicals ("Menzie 1969).
Hazardous Decomposition or Byproducts: Sulfur oxides and phosphorous
oxides are formed when heated to decomposition (*Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 115-90-2
Page 3 of 3
FENSULFOTHION
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Non-Specific -- Organic Phosphorus
Pesticides) (Hayes 1982, p. 301)
Skin: Yes (Non-Specific -- Organic Phosphorus
Pesticides) (Hayes 1982, p. 301)
Ingestion: Yes (Non-Specific -- Organic Phosphorus
Pesticides) (Hayes 1982, p. 301)
HealtK Hazards (Acute, Delayed, and Chronic): It displays
cholinesterase inhibiting properties (*ACGIH 1980). Death results
primarily from respiratory arrest stemming from failure of the respiratory
center, paralysis of respiratory muscles and intense bronchoconstriction
(*Gosselin 1976).
Signs and Symptoms of Exposure: This material may cause nausea,
vomiting, abdominal cramps, diarrhea, headache, giddiness, vertigo,
weakness, lack of muscle control, tearing, slurring of speech, difficult
breathing, convulsions, excessive salivation, tightness in chest, and
death from respiratory arrest (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) Move victim to fresh air; call emergency
medical ca're. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with the
material, immediately flush skin or eyes with running water for at least
15 minutes. Speed in removing material from skin is of extreme
importance. Remove and isolate contaminated clothing and shoes at the
site. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 55).
t
SECTION VI -- USE INFORMATION
This material is used as an insecticide, nematocide (>VSRI), and mosquito
larvicide (-Spencer 1973).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Wear
self-contained breathing apparatus and special protective clothing.. Keep
unnecessary people away; stay upwind. Do not touch spilled material; stop
leak if possible. Use water spray to reduce vapors. Take up with
noncombustible absorbent material. For large spills, dike far ahead of
spill (DOT 1984, Guide 55).
-------
CAS Registry Number: 116-06-3
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ALDICARB
CAS Registry Number: 116-06-3
Synonyms: Propionaldehyde, 2-Methyl-2-(Methylthio)-, 0-(Methyl-
carbamoyl)0xime; 2-Methyl-2-(Methylthio)Propanal, 0-((Methylamino)Carbonyl)
Oxime; 2-Methyl-2-(Methylthio)Propionaldehyde 0-(Methylcarbamoyl)Oxime;
Aldecarb; Carbamic Acid, Methyl-, 0-((2- Methyl-2-(Methylthio)Propylidene)
Araino) Derivative; Carbamyl; Carbanolate; ENT 27,093; NCI-C08640; QMS 771;
Propanal, 2-Methyl-2-(Methylthio)-, 0-((Methylamino)Carbonyl)Oxime;
Propionaldehyde, 2-Methyl-2-(Methylthio)-, 0-(Methylcarbamoyl)Oxime; UC 21149;
Union Carbide 21149; Union Carbide UC-21149; Temik TSK; Sulfone aldoxycarb;
Temic; Ambush; Propanal, 2-Methyl-2-(Methylthio)-, 0-((Methylamino)Carbonyl)
Oxime; Temic; Temik; Temik 10 G; Temik G 10
Chemical Formula: C-.H-.N.O.S
7 14 2 2
Molecular Weight: 190.23
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: T<->xicity information: LD,.- oral (mouse)
0.3 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 1.1950 at 25°C (*Farm Chemicals Handbook
1983)
Vapor Pressure (mmHg): Less than 0.5 at 20°C (*Sunshine 1969)
Melting Point: 210-214°F, 99-101°C (*Merck 1983)
-------
CAS Registry Number: 116-06-3
Page 2 of 4
ALDICARB
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 6 g/liter at 25°C (*Merck 1983)
Appearance and Odor: White crystals, slightly sulfurous odor ("Spencer
1982); commercial formulations are granular (*Farm Chemicals Handbook 1985)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Carbamate Pesticide, Solid)
Some of these materials may burn but none of them ignite readily. Small
fires: dry chemical, carbon dioxide, water spray, or foam. Large fires:
water spray, fog or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Carbamate
Pesticide, Solid) Stay upwind; keep out of low areas. Ventilate closed
spaces before entering them. Wear positive pressure breathing apparatus
and special protective clothing. Move container from fire area if you can
do it without risk. Fight fire from maximum distance. Dike fire control
water for later disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of nitrogen oxides and sulfur oxides (*Sax 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NIH 1979)
Conditions to Avoid: Unstable in alkali; poor stability at 122°F,
50°C (^Sunshine 1969).
-------
CAS Registry Number: 116-06-3
Page 3 of 4
ALDICARB
SECTION IV -- REACTIVITY DATA
Incompatibility (Materials to Avoid): Incompatible with highly
alkaline substances (*Farm Chemicals Handbook 1983).
Hazardous Decomposition or Byproducts: When heated, aldicarb emits
very toxic fumes of nitrogen oxides and sulfur oxides (*Sax 1984).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Yes (*Doull 1980)
Ingestion: Yes (*Doull 1980)
Health Hazards (Acute, Delayed, and Chronic): Aldicarb is a carbamate
pesticide (Hayes 1981, p. 447). This material is super toxic; the
probable oral lethal dose for humans is less than 5 rag/kg, or a taste
(less than 7 drops) for a 150-lb. person (*Gosselin 1976); it is extremely
toxic by both oral and dermal routes (*Doull 1980).
Signs and Symptoms of Exposure: Symptoms include headache, blurred
vision, nausea, vomiting, diarrhea, and abdominal pain. In severe cases,
unconsciousness and convulsions may occur (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Carbamate
Pesticide, Solid) Move victim to fresh air; call emergency medical care.
If not breathing, give artificial respiration. If breathing is difficult,
give oxygen. In case of contact with material, immediately flush skin or
eyes with running water for at least 15 minutes. Speed in removing
material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
This material is used as an insecticide, acaricide, and nematocide (*SRI).
-------
CAS Registry Number: 116-06-3
Page 4 of 4
ALDICARB
SECTION VII '-- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Carbamate Pesticide, solid) Keep unnecessary people
away; isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Ventilate closed spaces before entering them. Wear positive
pressure breathing apparatus and special protective clothing. Remove and
isolate contaminated clothing at the site. Do not touch spilled material;
stop leak if you can do it without risk. Use water spray to reduce
vapors. Small spills: take up with sand or other noncombustible
absorbent material and place into containers for later disposal. Small
dry spills: with clean shovel place material into clean, dry container
and cover; move containers from spill area. Large spills: dike far ahead
of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 117-52-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- COUMAFURYL
CAS Registry Number: 117-52-2
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 964) Coumarin,
3-(alpha-Acetonylfurfuryl)-4-Hydroxy-; 3-(alpha-Acetonylfurfuryl)-4-
Hydroxycoumarin; 2H-1-Benzopyran-2-one, 3-(1-(2-Furany1)-3-Oxobuty1)-
4-Hydroxy- (9CI); Foumarin; Fumarin; Fumasol; Furmarin; 3-(l-Furyl-3-
Acetylethyl)-4-Hydroxycoumarin; Krumkil; Lurat; Ratafin; Rat-A-Way; Tomarin
Chemical Formula: C H 0
Molecular Weight: 298.31
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (mouse)
14.7 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H.0=l): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 255°F, 124°C (Hayes 1982, p. 512; Merck 1983, p. 366)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Crystalline substance (Encyc Occupat Health and
Safety 1983, p. 560)
-------
CAS Registry Number: 117-52-2
Page 2 of 4
COUMAFURYL
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Coumarin Pesticide, Solid,
n.o.s.) Small fires: dry chemical, carbon dioxide, water spray or foam.
Large fires: water spray, fog or foam. Move container from fire area if
you can do so without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (DOT 1984,
Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Coumarin Pesticide,
Solid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny
entry. Stay upwind; keep out of low areas. Ventilate closed spaces
before entering them. Wear positive pressure breathing apparatus and
special protective clothing. Remove and isolate contaminated clothing at
the site. If water pollution occurs, notify the appropriate authorities
(DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 117-52-2
Page 3 of 4
COUMAFURYL
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: No (Encyc Occupat Health and Safety 1983,
p. 560)
Skin: Yes (Non-Specific Warfarin) (Hayes 1982,
p. 511)
Ingestion: Yes (Encyc Occupat Health and Safety
1983, P. 560)
Health Hazards (Acute, Delayed, and Chronic): Coumafuryl is very
similar to warfarin (Hayes 1982, p. 512). With a single large ingested
dose or chronic exposure, may cause hemorrhagic accidents (Encyc Occupat
Health and Safety 1983, p. 560).
Signs and Symptoms of Exposure: (Non-Specific -- Warfarins) May cause
death by hemorrhagic shock. After a few days or few weeks of repeated
ingestion, may cause nose bleeds and bleeding gums, small reddish spots
like a rash, bruises of the elbows, knees and buttocks, blood in urine and
stools, occasional paralysis due to a stroke (Gosselin 1984, p. III-395).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Treatment is as for warfarin
(Hayes 1982, p. 512). (Non-Specific -- Coumarin) Move victim to fresh
air; call emergency medical care. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. In case of contact
with material, immediately flush skin or eyes with running water for at
least 15 minutes. Speed in removing material from skin is of extreme
importance. Remove and isolate contaminated clothing and shoes at the
site. Keep victim quiet and maintain normal body temperature. Effects
may be delayed, keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Anticoagulant rodenticide (Farm Chemicals Handbook 1984, p. C-108).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Coumarin Pesticide, Solid, n.o.s.) Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. For small spills, absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. For
small dry spills, with clean shovel place material into clean, dry
container and cover; move containers from spill area. For large spills,
dike far ahead of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 117-52-2
Page 4 of 4
COUMAFURYL
COMMENTS
Sources searched but no information found:
Weast 1979
Hawley 1981
Sax 1984
DASE 1980
Oilman 1985
NIOSH/OSHA 1978
ACGIH 1984
-------
CAS Registry Number: 117-84-0
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DIOCTYL PHTHALATE
CAS Registry Number: 117-84-0
Synonyms: Di-n-Octyl Phthalate; 1,2-Benzenedicarboxylic Acid Dioctyl
Ester; 1,2-Benzenedicarboxylic Acid, Dioctyl Ester; Celluflex DOP; Dinopol
NOP; Dioctyl 0-Benzenedicarboxylate; DNOP; n-Dioctyl Phthalate; n-Octyl
Phthalate; 0-Benzenedicarboxylic Acid, Dioctyl Ester; Octyl Phthalate;
Phthalic Acid Dioctyl Ester; Phthalic Acid, Dioctyl Ester; Polycizer 162;
PX-138; Vinicizer 85; Benzenedicarboxylic Acid Di-n-Octylester; Dinopol NOP
Chemical Formula: C..H000.
24 38 4
Molecular Weight: 390.62
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC,... inhalation
(mouse) 0.005 mg/liter (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 446°F, 230°C at 5 mmHg (-Clayton and Clayton 1981-82)
Specific Gravity (H20=l): 0.9861 (*Clayton and Clayton 1981-82)
Vapor Pressure (mmHg): <0.2 at 150°C (-Clayton and Clayton 1981-82)
Melting Point: -22°F, -30°C (*Clayton and Clayton 1981-82)
Vapor Density (AIR=1): 16.0 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 117-84-0
Page 2 of 3
DIOCTYL PHTHALATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Insoluble ("Clayton and Clayton 1981-82)
Appearance and Odor: Liquid (-USEPA/ECAO 1980)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 426°F, 219°C (*Clayton and Clayton 1981-82)
Flammable Limits:
LEL: 0.3% (NFPA 1984, p. 325M-44)
UEL: Not Found
Extinguishing Methods: Water or foam may cause frothing. Water spray
carefully applied has been successful in extinguishing fires (NFPA 1984,
p. 325M-6).
Special Fire Fighting Procedures: Normal firefighting procedures.
When on fire, these materials offer no health hazard beyond that presented
by ordinary combustible materials ("NFPA 1978).
Unusual Fire and Explosion Hazards: Normal firefighting procedures
(*NFPA 1978)
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits acrid smoke and fumes (Sax 1984, p. 1224).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 117-84-0
Page 3 of 3
DIOCTYL PHTHALATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: No (-Patty 1963)
Skin: No (Clayton and Clayton 1981-82, p. 2349)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): This chemical is rated
as slightly to moderately toxic, with a probable oral lethal dose for
humans of 0.5-15 g/kg body weight, or between 1 ounce and 1 quart dose for
a 70 kg (150 Ib) person ("Gosselin 1976). This chemical rarely causes
skin difficulties and its low vapor pressure precludes the inhalation of
any significant amounts (*Encyc Occupat Health and Safety 1971).
Signs and Symptoms of Exposure: The chemical might cause mucous
membrane irritation and central nervous system depression if absorbed
(*Gosselin 1976). Human dermal patch testing showed no irritation and
sensitization (*Clayton and Clayton 1981-82).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Procedures are those for general
poisoning. After oral exposure, establish respiration and prevent
absorption. After skin exposure, the skin should be washed thoroughly
with soap and water. After eye exposure, eyes should be irrigated with
tap water (*Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
It is used as a plasticizer for plastics; rubber materials (*Clayton and
Clayton 1981-82); cellulose ester resins; polystyrene resins; and vinyl
resins (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
The synthesis of phthalates requires good ventilation in order to prevent
contamination of air with phthalic anhydride or alcohols. There maybe
some need for skin protection (*Encyc Occupat Health and Safety 1971).
-------
CAS Registry Number: 119-38-0
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ISOPROPYLMETHYLPYRAZOLYL DIMETHYLCARBAMATE
CAS Registry Number: 119-38-0
Synonyms:. Carbamic Acid, Dimethyl-, l-Isopropyl-3-Methylpyrazol-5-yl
Ester; l-Isopropyl-3-Methyl-5-Pyrazolyl Dimethylcarbaraate; 5-Methyl-2-
Isopropyl-3-Pyrazolyl Dimethylcarbamate; Carbamic Acid, Dimethyl-, 1-Isopropyl-
3-Methylpyrazol-5-yl Ester; Carbamic Acid, Dimethyl-, 3-Methyl-l-(l-
Methylethyl)-lH-Pyrazol-5-yl Ester; Dimethyl-5-(l-Isopropyl-3-Methyl-
Pyrazolyl)-Carbamate; Dimethylcarbamic Acid l-Isopropyl-3-Methylpyrazol-5-yl
Ester; Dimethylcarbamic Acid 3-Methyl-l-(l-Methylethyl)-lH-Pyrazol-5-yl Ester;
ENT 19,060; G 23611; Primin; Pyrazol-5-ol, l-Isopropyl-3-Methyl-,
Dimethylcarbamate; Saolan; Isolan
Chemical Formula: ci0Hi7N302
Molecular Weight: 211.27
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD. oral (mouse)
9.8 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 217°F, 103°C at 0.7 mm (*Sax 1979)
Specific Gravity (H20=l): 1.07 at 20°C (*Sax 1979)
Vapor Pressure (mmHg): 0.001 at 20°C (*Sunshine 1969)
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 119-38-0
Page 2 of 3
ISOPROPYLMETHYLPYRAZOLYL DIMETHYLCARBAMATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Miscible in water (*Hawley 1977)
Appearance and Odor: Colorless liquid (Hayes 1982, p. 454)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Use methods for liquid carbamate pesticides
(Hayes 1982, p. 454). Small fires: dry chemical, carbon dioxide, water
spray, or foam. Large fires: water spray, fog, or foam. Move container
from fire area if you can do it without risk. Fight fire from maximum
distance. Dike fire control water for later disposal; do not scatter the
material (DOT 1984, Guide 55).
Special Fire Fighting Procedures: As with other liquid carbamate
pesticides (Hayes 1982, p. 454), keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of nitrogen oxides (Sax 1984, p. 1170).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of nitrogen oxides (Sax 1984, p. 1170).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 119-38-0
Page 3 of 3
ISOPROPYLMETHYLPYRAZOLYL DIMETHYLCARBAMATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Gosselin 1984, p. 11-306)
Skin: Yes (Sax 1984, p. 1170)
Ingestion: Yes (Sax 1984, p. 1170)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
extremely toxic. Probable oral lethal dose in humans is 5-50 mg/kg or
between 7 drops and 1 teaspoonful for a 150-lb. person (*Gosselin 1976).
A cholinesterase inhibitor; although it is not an organic phosphate, it
resembles that group in action (*Sax 1979).
Signs and Symptoms of Exposure: Can cause death due to respiratory
arrest. Symptoms include cool extremities; trembling; fixed pinpoint
pupils; nausea; vomiting; slight bluing of skin; lips and nailbeds;
tearing; diarrhea; excessive salivation; sweating; slurring of speech;
jerky movements; loss of bladder control; convulsions; coma and death
(*Gosselin 1976, Gosselin 1984, p. 11-306).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: A liquid carbamate pesticide
(Hayes 1982, p. 454). Move victim to fresh air; call emergency medical
care. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Systemic aphicide used in Europe (Buchel 1983, p. 128); insecticide (Merck
1983, p. 744). Currently of little commercial interest (-Worthing 1979).
Not registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors (see Section V above). Treat as a liquid carbamate
pesticide (Hayes 1982, p. 454). Do not touch spilled material; stop leak
if you can do it without risk. Use water spray to reduce vapors. Small
spills: take up with sand or other noncombustible absorbent material and
place into containers for later disposal. Large spills: dike far ahead
of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 122-14-5
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- FENITROTHION
CAS Registry Number: 122-14-5
Synonyms: 8057HC; 80557HC; AC 47,300; Accothion; Aceothion; Agrothion;
Akotion; Bay 41831; Bayer 41831; Bayer S 5660; CL 47300; CP 47114; Cyfen;
Cytel; ENT 25,715; Falithion; Fentrothione; Folithion; m-Cresol, 4-Nitro-,
0-Ester with 0,0-Dimethyl Phosphorothioate; MEP (Pesticide); Metathio E-50;
Metathion; Metathione; Metathionine; Metathionine E50; Metation; Methathion;
Methylnitrophos; Nitrophos; Novathion; Nuvanol; 0,0-Dimethyl 0-(3-Methyl)
Phosphorothioate; 0,0-Dimethyl 0-(3-Methyl-4-Nitrophenyl) Thiophosphate;
0,0-Dimethyl 0-(4-Nitro-3-Methylphenyl)Thiophosphate; 0,0-Dimethyl
0-4-Nitro-m-Tolyl Phosphorothioate; Oleosumifene; OMS 43; Ovadofos;
Phenitrothion; Phosphorothioic Acid, 0,0-Dimethyl 0-(3-Methyl-4-Nitrophenyl)
Ester; Phosphorothioic Acid, 0,0-Dimethyl 0-(4-Nitro-m-Tolyl) Ester; S 112A; S
5660; S-1102A; Sumithian; Sumithion
Chemical Formula: C H NO PS
Molecular Weight: 277.25
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC,... inhalation
(rat) 0.378 mg/liter/4 hours (-NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 244°F, 118°C at 0.05 mmHg (*Merck 1976)
Specific Gravity (H20=l): 1.32 at 25°/4°C (-Martin 1974)
Vapor Pressure (mmHg): 6 x 10"6 at 20°C (-Martin 1974)
-------
CAS Registry Number: 122-14-5
Page 2 of 4
FENITROTHION
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (*Merck 1976)
0
Appearance and Odor: Brownish-yellow oil (*Martin 1974; *Merck 1976)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This compound is an organophosphate insecticide
(Encyc Occupat Health and Safety 1983, p. 1623). Small fires: dry
chemical, carbon dioxide, water spray, or foam. Large fires: water
spray, fog or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Organophosphate
Pesticide n.o.s.) Move containers from fire area if you can do so without
risk. Fight fire from maximum distance. Dike fire control water for
later disposal; do not scatter the material. Wear positive pressure
breathing apparatus and special protective clothing (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes, for 2 years if stored at 20-25°C (Hayes 1982,
p. 365)
Conditions to Avoid: Unstable in alkaline media. Do not store
above 40°C (Hayes 1982, p. 365).
Incompatibility (Materials to Avoid): Unstable in alkaline media
(Hayes 1982, p. 365)
-------
CAS Registry Number: 122-14-5
Page 3 of 4
FENITROTHION
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of oxides of nitrogen, phosphorus and sulfur
(Sax 1984, p. 1174). Decomposition at 100-140°C produces a mixture of
organophosphorus polymers (*Menzie 1969).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Yes (Sax 1984, p. 1174)
Ingestion: Yes (Sax 1984, p. 1174)
Health Hazards (Acute, Delayed, and Chronic): This compound is an
organophosphate insecticide. It is a highly toxic cholinesterase
inhibitor (Hawley 1981, p. 452) that acts on the nervous system (Doull
1980, p. 367). Does not cause delayed neurotoxicity and contact produces
little irritation (Hayes 1982, p. 365).
Signs and Symptoms of Exposure: Nausea is often the first symptom,
followed by vomiting; abdominal cramps; diarrhea; excessive salivation;
headache; giddiness; dizziness; weakness; tightness in the chest; loss of
muscle coordination; slurring of speech, muscle twitching (particularly
the tongue and eyelid); respiratory difficulty; blurring or dimness of
vision; pinpoint pupils; profound weakness; mental confusion;
disorientation and drowsiness ("Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Organophosphate
Pesticide n.o.s) Move victim to fresh air; call emergency medical care.
If not breathing, give artificial respiration. If breathing is difficult,
give oxygen. In case of contact with material, immediately flush skin or
eyes with running water for at least 15 minutes. Speed in removing
material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature (DOT 1984, Guide 55).
-------
CAS Registry Number: 122-14-5
Page 4 of 4
FENITROTHION
SECTION VI -- USE INFORMATION
It is a selective acaricide ("Martin 1974) and a contact and stomach
insecticide (*Spencer 1973). Used to control chewing and sucking insects
on rice, orchard fruits, vegetables, cereals, cotton and forest. Also
protects against flies, mosquitoes, and cockroaches (Farm Chemicals
Handbook 1984, p. C-101).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Organophosphate Pesticide n.o.s.) Keep unnecessary
people away; isolate hazard area and deny entry. Stay upwind; keep out of
low areas. Ventilate closed spaces before entering them. Wear positive
pressure breathing apparatus and special protective clothing. Remove and
isolate contaminated clothing at the site. Do not touch spilled material;
stop leak if you can do so without risk. Use water spray to reduce
vapors. Small spills: absorb with sand or other noncombustible absorbent
material and place into containers for later disposal. Large spills:
dike far ahead of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 123-31-9
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- HYDROQUINONE
CAS Registry Number: 123-31-9
Synonyms: 1,4-Benzenediol; 1,4-Dihydroxybenzene; 4-Hydroxyphenol;
Alpha-Hydroquinone; Arctuvin; Benzohydroquinone; Benzoquinol; Beta-Quinol;
Black and White Bleaching Cream; Diak 5; Dihydroxybenzene; Eldopaque;
Eldoquin; HE 5; Hydroquinol; Hydroquinole; NCI-C55834; p-Benzenediol;
p-Dihydroxybenzene; p-Dioxobenzene; p-Hydroquinone; p-Hydroxyphenol;
para-Dihydroxybenzene; para-Dioxybenzene; para-Hydroquinone; Phiaquin; Quinol;
Tecquinol; Tenox HQ; Tequinol; USAF EK-356
Chemical Formula: C,H,0_
o b /
Molecular Weight: 110.11
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 2 mg/m3 (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 2 mg/m3; STEL 4 mg/m3 (*ACGIH 1980)
IDLH.: 200 mg/m3 (NIOSH/OSHA 1978, p. 114)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 545-549°F, 285-287°C (*Merck 1976)
Specific Gravity (H20=l): 1.332 at 15°C (Merck 1983, p. 699)
Vapor Pressure (mmHg): 4 at 150°C (*Clayton and Clayton 1981-82)
Melting Point: 338-340°F, 170-171°C (*Merck 1976)
Vapor Density (AIR=1): 3.81 (*Sax 1975)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in 14 parts water (*Merck 1976)
-------
CAS Registry Number: 123-31-9
Page 2 of 3
HYDROQUINONE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless (*Sax 1975) to white crystals (*IARC
1972-1985).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Pojnt (Method Used): 329°F (CC) (''"Sax 1975)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: For small fires use dry chemical, carbon
dioxide, water spray or foam. Move container from fire area if you can do
so without risk (*DOT 1984). This compound is a slight fire or explosion
hazard (*NFPA 1978).
Special Fire Fighting Procedures: Wear self-contained (positive
pressure if available) breathing apparatus and full protective clothing
(*DOT 1984).
Unusual Fire and Explosion Hazards: Dust cloud may explode if ignited
in an enclosed area (*CHRIS 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*NFPA 1978)
Conditions to Avoid: Oxidizes in air (Merck 1983, p. 699)
Incompatibility (Materials to Avoid): It can react with oxidizing
materials (*Sax 1975) and is rapidly oxidized in the presence of alkaline
materials (*Merck 1976).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-DOT 1984)
Skin: Yes (*IARC 1972-1985)
Ingestion: Yes (*IARC 1972-1985)
-------
CAS Registry Number: 123-31-9
Page 3 of 3
HYDROQUINONE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): This material is very
toxic; the probable oral lethal dose for humans is 50-500 mg/kg, or
between 1 teaspoon and 1 ounce for a 150 Ib. person. It is irritating but
not corrosive. Fatal human doses have ranged from 5-12 grams, but 300-500
mg have been ingested daily for 3-5 months without ill effects (*Gosselin
1976). Death is apparently initiated by respiratory failure or anoxia
("Encyc Occupat Health and Safety 1971).
Signs and Symptoms of Exposure: Ingestion has caused dizziness, a
sense of suffocation, increased rate of respiration, vomiting, pallor,
muscular twitching, headache, labored breathing, cyanosis and collapse.
Urine is usually green or brownish-green in color ("Encyc Occupat Health
and Safety 1971). Vapors produce irritation, tearing and corneal
ulceration of the eyes (*Grant 1974).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. Remove and isolate contaminated clothing and
shoes at the site. In case of contact with material, immediately flush
skin or eyes with running water for at least 15 minutes ("DOT 1984).
SECTION VI -- USE INFORMATION
Photographic developer and reducer; antioxidant for fats and oils;
polymerization inhibitor; stabilizer in paints, varnishes, motor fuels,
and oils; in human medicine for skin blemishes; chemical intermediate for
dyes; reagent in phosphate analysis ("SRI; "Merck 1976).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Wear self-contained (positive pressure if
available) breathing apparatus and full protective clothing. Do not touch
spilled material; stop leak if you can do it without risk. Small spills:
take up with sand or other non-combustible absorbent material and place
into containers for later disposal. Small dry spills: with clean shovel
place material into clean, dry container and cover; move containers from
spill area. Large spills: dike far ahead of spill for later disposal
(-DOT 1984).
-------
CAS Registry Number: 123-73-9
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- CROTONALDEHYDE
CAS Registry Number: 123-73-9
Synonyms: (E)-Crotonaldehyde; 2-Butenal (trans); 2-Butenal, (E)-;
beta-Methyl Acrolein; Crotenaldehyde; Crotonal; Crotonaldehyde, (E)-; Crotonic
Aldehyde; E-2-Butenal; NCI-C56279; Propylene Aldehyde; Topanel; Topanel CA;
trans-2-Butenal; trans-Crotonaldehyde
Chemical Formula: C.H.O
4 6
Molecular Weight: 70.10
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 2 ppm (NIOSH/OSHA 1978, p. 72)
ACGIH TLV: TWA 2 ppm (6 mg/m3); STEL 6 ppm (18 mg/m3) (ACGIH 1983,
p. 16)
IDLH: 400 mg/m3 (NIOSH/OSHA 1978, p. 72)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 219.2°F, 104°C (*Sunshine 1969)
Specific Gravity (H20=l): 0.853 at 20°C/20°C (Merck 1983, p. 372)
Vapor Pressure (mmHg): 19 at 20°C (^Sunshine 1969)
Melting Point: -101°F, -74°C (*Weast 1979)
Vapor Density (AIR=1): 2.41 (Merck 1983, p. 372)
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 123-73-9
Page 2 of 4
CROTONALDEHYDE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: 18.1 g/100 mL at 20°C (Merck 1983, p. 372)
Appearance and Odor: Crotonaldehyde is a water-white to straw-colored
liquid (*NFPA 1978) with a pungent, suffocating odor (ACGIH 1980, p. 107),
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 13°C (OC) (Merck 1983, p. 372)
Flammable Limits:
LEL: 2.1% (*Sunshine 1969)
DEL: 15.5% (*Sunshine 1969)
Extinguishing Methods: Use dry chemical, foam, or carbon dioxide;
water may be ineffective but should be used to keep fire-exposed
containers cool. If leak or spill has not ignited, use water spray to
disperse vapors. Water spray may be used to flush spills away from
exposures (*NFPA 1978).
Special Fire Fighting Procedures: All exposed skin surfaces should be
covered. Wear protective clothing including self-contained breathing
apparatus, coat, pants, gloves, boots, and bands around arms, wrists,
legs, and waist. Massive or advanced fires should be fought from a safe
distance or protected location (*NFPA 1978). Isolate area for one-half
mile in all directions if tank car or truck involved in fire (DOT 1984,
Guide 28).
Unusual Fire and Explosion Hazards: Vapors form explosive mixtures in
air (-NFPA 1978) or in sewers (*NIOSH/OSHA 1981).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: Oxygen, heat, elevated pressures (-NFPA 1978)
Incompatibility (Materials to Avoid): Nitric acid (Sax 1984, p. 817).
Hazardous Decomposition or Byproducts: Hazardous peroxides and acids
(*NFPA 1978).
-------
CAS Registry Number: 123-73-9
Page 3 of 4
CROTONALDEHYDE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Yes (*NFPA 1978)
May Not Occur:
Conditions to Avoid: Contact with alkaline materials such as
caustic ammonia or amines, or at elevated temperatures (*NFPA 1978).
SECTION"v -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*NFPA 1978)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Although slightly less
toxic, crotonaldehyde is similar chemically and toxicologically to
acrolein (*Gosselin 1976) which is rated as extremely toxic (Gosselin
1984, p. VI-186). Toxic concentrations for human inhalation have been
reported at 12 mg/m3/10 minutes. Irritant dose to human eye is 45 ppm
(*NIOSH/RTECS 1985). As with acrolein, vapor exposures cause severe and
painful eye irritation, damage to cornea, lacrimation (tearing),
irritation of nasal membranes, pulmonary edema (filling of lungs with
fluid) (*NFPA 1978, *Rumack 1975 to Present) and gastrointestinal distress
when ingested (*Rumack 1975 to Present).
Signs and Symptoms of Exposure: Irritation of eyes causes reddening
and intense lacrimation (tearing) and pain, irritation to nasal membranes
and difficulty in breathing ("Rumack 1975 to Present, *ACGIH 1980);
abdominal distress when ingested (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration; if
breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at site if possible. In case of contact with liquid
material, immediately flush skin or eyes with running water for at least
15 minutes (DOT 1984, Guide 28).
SECTION VI -- USE INFORMATION
Chemical intermediate for several compounds in a variety of industrial
processes (surfactants, textiles, paper, fuels, insecticides, leather
tanning, etc.) (-SRI). Used in chemical warfare (Merck 1983, p. 372).
-------
CAS Registry Number: 123-73-9
Page 4 of 4
CROTONALDEHYDE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Remove all ignition sources and ventilate area of spill (*NIOSH/OSHA
1981). No flares, smoking, or flames in hazard area. Do not touch
spilled material; stop leak if you can do so without risk. Wear positive
pressure breathing apparatus and special protective clothing (DOT 1984,
Guide 28).
-------
CAS Registry Number: 124-65-2
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- SODIUM CACODYLATE
CAS Registry Number: 124-65-2
Synonyms: Arsine Oxide, Dimethylhydroxy-, Sodium Salt; Alkarsodyl; Ansar
160; Ansar 560; Arsecodile; Arsicodile; Arsine Oxide, Hydroxydimethyl-, Sodium
Salt; Arsinic Acid, Dimethyl-, Sodium Salt; Arsycodile; Arsysodila; Cacodylic
Acid Sodium Salt; Cacodylic Acid, Sodium Salt; Chemaid; Hydroxydimethylarsine
Oxide, Sodium Salt; Rad-E-Cate; Silvisar; Sodium Dimethylarsinate; Sodium
Dimethylarsonate; Sodium Salt of Cacodylic Acid; [(Dimethylarsino)oxy]Sodium
As-Oxide
Chemical Formula: C H.AsO Na
Molecular Weight: 159.98
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 500 ug (As)/m3 (NIOSH/RTECS 1983, Volume 1, p. 444)
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD_ oral (mouse) 4
mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 140°F, 60°C for trihydrate (*Weast 1979); liquifies in
water of hydration at 140°F, 60°C and becomes anhydrous at 284°F, 120°C
for trihydrate (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 124-65-2
Page 2 of 3
SODIUM CACODYLATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Soluble; 2000 g/liter at 15-20°C for trihydrate
(*Weast 1979)
Appearance and Odor: White, amorphous crystals or powder (*Hawley
1977) with a slight odor (*Merck 1976)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Pesticide, Solid, n.o.s.)
Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam
(DOT 1984, Guide 53).
Special Fire Fighting Procedures: (Non-Specific -- Pesticide, Solid,
n.o.s.) Keep unnecessary people away; isolate hazard area. Stay upwind;
keep out of low areas. Wear self-contained breathing apparatus and full
protective clothing. Move container from fire area, if you can do so
without risk (DOT 1984, Guide 53).
Unusual Fire and Explosion Hazards: Poisoning potential is high when
heated to decomposition (-"Sax 1979).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Water solution in contact with
active metals (iron, aluminum, zinc) (*Sax 1979)
Hazardous Decomposition or Byproducts: Dangerous when heated to
decomposition or on contact with acids or acid fumes, because it emits
highly toxic fumes of arsenic (*Sax 1975).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 124-65-2
Page 3 of 3
SODIUM CACODYLATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Hayes 1982, p. 42)
Health Hazards (Acute, Delayed, and Chronic): Moderately toxic;
probable oral lethal dose in humans is 0.5-5 g/kg or between 1 ounce and 1
pint°(or 1 Ib.) for a 70 kg (150 Ib.) person (-Gosselin 1976). It may
cause disturbances of the blood, kidneys, and nervous system (*Sax 1975).
Signs and Symptoms of Exposure: Exposure results in marked irritation
of the stomach and intestines with nausea, vomiting, and diarrhea. In
severe cases, patient goes into collapse and shock with weak, rapid pulse,
cold sweat, coma, and death (*Sax 1975).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Pesticide, Solid,
n.o.s.) Move'victim to fresh air; call emergency medical care. Remove
and isolate contaminated clothing and shoes at the site. In case of
contact with material, immediately flush skin or eyes with running water
for at least 15 minutes (DOT 1984, Guide 53).
SECTION VI -- USE INFORMATION
This material has been used as a nonselective herbicide and for general
weed control (*Farm Chemicals Handbook 1961).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Pesticide, Solid, n.o.s.) Wear self-contained breathing
apparatus and full protective clothing. Do not touch spilled material;
stop leak if you can do so without risk. Small spills: absorb with sand
or other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53).
-------
CAS Registry Number: 124-87-8
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PICROTOXIN
CAS Registry Number: 124-87-8
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 3, p. 175) Cocculin;
Cocculus; Cocculus Solid; Fish Berry; Indian Berry; Oriental Berry; Picrotin,
compound with Picrotoxinin (1:1); Picrotoxine; 3,6-Methano-8H-l,5,7-
Trioxacyclopenta[ij]Cycloprop[a]Azulene-4,8(3H)-Dione, Hexahydro-2a-Hydroxy-
9-(l-Hydroxy-l-Methylethyl)-8b-Methyl-, [laR-(la.alpha.,2a. beta.,3.beta.,
6.beta.,6a.beta.,8aS*,8b.beta.,9S*)]-, compound with [laR-(la.alpha.,2a.beta.,
3.beta.,6.beta.,6a.beta.,8aS*,8b.beta,9R*)]-Hexahydro-2a-Hydroxy-8b-Methy1-9 -
(1-Methylethenyl)-3,6-Methano-8H-1,5,7-Trioxacyclopenta[ij] Cycloprop[a]
Azulene-4,8(3H)-Dione(l:l)
Chemical Formula: c3oH340i3 (Weast 1983, p. C456)
Molecular Weight: 602.60 (Weast 1983, p. C456)
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD. oral (cat)
low
1.75 mg/kg (^NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 397°F, 203°C (Merck 1983, p. 1069)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 124-87-8
Page 2 of 3
PICROTOXIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: 1 g/350 mL (Merck 1983, p. 1069)
Appearance and Odor: Shiny leaflets with intensely bitter taste (Merck
1983, p. 1069); micro-crystalline powder. Odorless (Hawley 1981, p. 816)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Alkaloid) Use dry chemical,
carbon dioxide, water spray, or foam for small fires. Use water spray,
fog, or foam for large fires. Move container from fire area if this can
be done without risk (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Alkaloid) Isolate
hazard area and deny entry. Wear positive pressure breathing apparatus
and special protective clothing (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition it
emits acrid smoke and fumes (Sax 1984, p. 2231).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Hawley 1981, p. 816)
Conditions to Avoid: Decomposing heat (Sax 1984, p. 2231)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Acrid smoke and fumes when
heated to decomposition (Sax 1984, p. 2231)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 124-87-8
Page 3 of 3
PICROTOXIN
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Oilman 1985, p. 585)
Skin: Yes (Oilman 1985, p. 585)
Ingestion: Yes (Sax 1984, p. 2231)
Health Hazards (Acute, Delayed, and Chronic): Highly toxic and a dose
of 20 mg may produce symptoms of severe poisoning (Oilman 1985, p. 585).
A human lethal dose of 1.5 mg/kg has been reported (NIOSH/RTECS 1983,
Volume 3, p. 175). It is an alkaloid convulsant poison (Sax 1984,
p. 2231).
Signs and Symptoms of Exposure: Picrotoxin is a powerful stimulant and
affects all portions of the central nervous system. At doses approaching
convulsant levels, signs and symptoms include salivation, elevated blood
pressure, frequent vomiting, rapid breathing (Oilman 1985, p. 584).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Alkaloid) Move
victim to fresh air; call emergency medical care. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. If case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Speed in removing material from skin is of
extreme importance. Remove and isolate contaminated clothing and shoes at
the site. Keep victim quiet and maintain normal body temperature.
Effects may be delayed, keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Used in medicine as a central nervous system stimulant and antidote for
barbiturate poisoning (Hawley 1981, p. 816). Reportedly, this material is
not currently regarded as a useful therapeutic agent since it is not a
selective respiratory stimulant (Oilman 1985, p. 585).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Alkaloid) Keep unnecessary people away; isolate hazard
area and deny entry. Stay upwind; keep out of low areas. Ventilate
closed spaces before entering them. Wear positive pressure breathing
apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site. If water pollution occurs, notify
appropriate authorities. Do not touch spilled material; stop leak if you
can do it without risk. Use water spray to reduce vapors. Small spills:
take up with sand or other noncombustible absorbent material and place
into containers for later disposal. Small dry spills: with clean shovel
place material into clean, dry container and cover; move containers from
spill area. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 55).
-------
CAS Registry Number: 126-98-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- METHACRYLONITRILE
CAS Registry Number: 126-98-7
Synonyms: 2-Cyano-l-Propene; 2-Cyanopropene; 2-Cyanopropene-l; 2-Methyl-2-
Propenenitrile; 2-Methylacrylonitrile; 2-Methylpropenenitrile; 2-Propene-
nitrile, 2-Methyl-; alpha-Methacrylonitrile; alpha-Methylacrylonitrile;
Isopropene Cyanide; Isopropenylnitrile; USAF ST-40
Chemical Formula: C.H N
Molecular Weight: 67.10
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 1 ppm (3 mg/m3) (skin); STEL 2 ppm (6 tng/m3) (skin)
(*ACGIH 1980)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD. oral (mouse)
15 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 194°F, 90.3°C (*Merck 1976)
Specific Gravity (H20=l): 0.8001 at 20/4°C (*Merck 1976)
Vapor Pressure (mmHg): 40 at 12.8°C (*Clayton and Clayton 1981-82)
Melting Point: -32.4°F, -35.8°C (Merck 1983, p. 850)
Vapor Density (AIR=1): 2.31 (-Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 2.57% by weight in water at 20°C; 2.69% by weight
in water at 50°C (*Merck 1976)
-------
CAS Registry Number: 126-98-7
Page 2 of 3
METHACRYLONITRILE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless liquid with an odor similar to bitter
almond (*Clayton and Clayton 1981-82; -Encyc Occupat Safety and Health
1971)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 55°F, 13°C (*Merck 1976)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Usual precautions for flammable liquid should
be applied (*Encyc Occupat Health and Safety 1971).
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Methacrylonitrile evolves
flammable concentrations of vapor at temperatures down to 12.8°C. Thus,
at room temperatures, flammable concentrations are liable to be present.
Toxic fumes are released when the material burns. Also, the chemical will
explode due to its tendency to polymerize violently (*Encyc Occupat Health
and Safety 1971).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Encyc Occupat Health and Safety 1971)
Stable:
Conditions to Avoid: Heat (Sax 1984, p. 1795)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Toxic fumes of nitrogen oxides
are formed upon heating to decomposition (Sax 1984, p. 1795).
Hazardous Polymerization: May Occur: Yes (*Encyc Occupat Health and
Safety 1971)
May Not Occur:
Conditions to Avoid: Not Found
-------
CAS Registry Number: 126-98-7
Page 3 of 3
METHACRYLONITRILE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Hawley 1977)
Skin: Yes (*Hawley 1977)
Ingestion: Yes (*Hawley 1977)
Health Hazards (Acute, Delayed, and Chronic): A lacrimator (causes
tearing); an insidious poison which causes delayed skin reactions (*Merck
1976). Very readily absorbed through skin (-ACGIH 1980). Highly toxic
(*Hawley 1977).
Signs and Symptoms of Exposure: Intense lacrimation (tearing) with
reddening of eyes and pain, difficulty in breathing; choking sensation;
pain and reddening of exposed skin (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Establish respiration. Prevent
absorption. Remove people from contaminated atmosphere as rapidly as
possible. Remove contaminated clothing. Wash exposed areas of the body
with soap and water. Warn emergency room personnel that there is possible
exposure to lacrimators and they should wear masks, aprons and gloves to
avoid contamination ('vRumack 1975 to Present).
SECTION VI -- USE INFORMATION
Used in the preparation of homopolymers and copolymers; as intermediate in
preparation of acids, amides, amines, nitriles (*Merck 1976). Also used
in the manufacture of elastomers, coatings, plastics ("Hawley 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Wear eye protection (see Section V above). Methacrylonitrile cannot be
detected by its smell even at concentrations which are already dangerous
for humans. Hence, special attention must be given to ventilation and
estimations of the amount of poison present must be carried out frequently
("Lefaux 1968). Suitable respiratory protective equipment (positive
pressure) and clothing should be used (*Encyc Occupat Health and Safety
1971).
-------
CAS Registry Number: 128-56-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- SODIUM ANTHRAQUINONE-1-SULFONATE
CAS Registry Number: 128-56-3
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 407) 1-Arithracen-
sulfonic Acid, 9,10-Dihydro-9,10-Dioxo-, Sodium Salt
Chemical Formula: C1/H^OcS»Na
14 7 5
Molecular Weight: 310.26
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD,_n oral (rabbit)
14 mg/kg (''-NIOSH/RTECS 1985) (SUSPECT)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Not Found
-------
CAS Registry Number: 128-56-3
Page 2 of 3
SODIUM ANTHRAQUINONE-1-SULFONATE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Not Found
Speciaf Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Not Found
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Not Found
-------
CAS Registry Number: 128-56-3
Page 3 of 3
SODIUM ANTHRAQUINONE-1-SULFONATE
SECTION VI -- USE INFORMATION
Not Found
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Not Found
COMMENTS
Sources searched but no information found:
Sax 1984
DOT 1984
NFPA 1984
Student 1981
Weiss 1980
Merck 1983
CHRIS 1978
Doull 1980
Clayton and Clayton 1981-82
ACGIH 1983
NIOSH/OSHA 1978
Hawley 1981
Weast 1979
Gosselin 1984
Farm Chemicals Handbook 1984
Encyc Occupat Health and Safety 1983
-------
CAS Registry Number: 129-00-0
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PYRENE
CAS Registry Number: 129-00-0
Synonyms: Benzo[d,e,f]Phenanthrene; Benzo[def]Phenanthrene; beta-Pyrene
Chemical Formula: C,,.Hiri
lo 1U
Molecular Weight: 202.26
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: TLV for coal tar pitch volatiles, as benzene
solubles: TWA 0.2 mg/m3. Coal tar pitch volatiles are suspected human
carcinogens (ACGIH 1985, p. 41). Toxicity information: ^C,.,. inhalation
(rat) 0.17 mg/liter (*NIOSH/RTECS 1985) (SUSPECT)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 759°F, 404°C (*Merck 1976) (SUSPECT)
Specific Gravity (H20=l): 1.27 at 23°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: 313°F, 156°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.135 mg/liter in water (-MacKay 1977)
Appearance and Odor: Colorless solid (Sax 1984,. p. 2324); solid and
solutions have a slight blue fluorescence (Merck 1983, p. 1149)
-------
CAS Registry Number: 129-00-0
Page 2 of 3
PYRENE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits acrid smoke and fumes (Sax 1984, p. 2324).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits acrid smoke and fumes (Sax 1984, p. 2324)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Clayton and Clayton 1981-82,
p. 3361)
Skin: Yes (Hawley 1981, p. 872)
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Pyrene is a carcinogenic
agent and is absorbed by the skin (Hawley 1981, p. 872). It is a skin
irritant, a suspected mutagen, and an equivocal tumor-causing agent (Sax
1984, p. 2324). Workers exposed to 3 to 5 mg/m3 of pyrene exhibited
some teratogenic effects (Clayton and Clayton 1981-82, p. 3361). Pyrene
is a polycyclic aromatic hydrocarbon (PAH). The acute toxicity of pure
PAHs appears low when administered orally or dermally to rats or mice
(Encyc Occupat Health and Safety 1983, p. 1758). Human exposure to PAHs
-------
CAS Registry Number: 129-00-0
Page 3 of 3
PYRENE
SECTION V -- HEALTH HAZARD DATA (Continued)
is almost exclusively via the gastrointestinal and respiratory tracts, and
approximately 99 percent is ingested in the diet. Despite the high
concentrations of pyrene to which humans may be exposed through food,
there is currently little information available to implicate diet-derived
PAHs as the cause of serious health effects (NRC 1983, p. ES-6) .
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Establish open airway and
respiration. If conscious, induce vomiting with syrup of ipecac. Dermal
exposure should be minimized by washing the exposed surface with soap and
water. Irrigate the eyes with plain tap water ("Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
Biochemical research (Hawley 1981, p. 872).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact. Wear self-contained breathing
apparatus and full protective clothing (see Section V).
COMMENTS
Sources searched but no information found:
ACGIH 1983
NIOSH/OSHA 1978
DOT 1984
NFPA 1984
Student 1981
Weiss 1980
CHRIS 1978
Arena 1979
Gosselin 1984
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
Physicians' Desk Reference 1985
Oilman 1985
-------
CAS Registry Number: 129-06-6
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- WARFARIN SODIUM
CAS Registry Number: 129-06-6
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 964) Coumarin,
3-(alpha-Acetonylbenzyl)-4-Hydroxy-, Sodium Salt; 3-(alpha-Acetonylbenzyl)-4-
HydroxyCoumarin Sodium Salt; Athrombin; 2H-l-Benzopyran-2-one, 4-Hydroxy-3-
(3-Oxo-l-Phenylbutyl)-, Sodium Salt; Coumadin Sodium; Coumafene Sodium;
Cumadin; Marevan; Marevan (Sodium Salt); Panivarfin; Panwarfin; Prothromadin;
Ratsul Soluble; Sodium, ((3-(alpha-Acetonylbenzyl)-2-Oxo-2H-l-Benzopyran-4-yl)
oxy)-; Sodium Coumadin; Sodium Warfarin; Tintorane; Varfine; Waran; Warcoumin;
Warfarin, Sodium deriv.; Warfarin, Sodium Salt; Warfilone
Chemical Formula: C H _04Na
Molecular Weight: 330.33
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD, oral (human)
15 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=l): Not Found
-------
CAS Registry Number: 129-06-6
Page 2 of 4
WARFARIN SODIUM
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Freely soluble (Merck 1983, p. 1441)
Appearance and Odor: Slightly bitter crystalline powder (Merck 1983,
p. 1441)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Coumarin Derivative Pesticide,
Solid, n.o.s.) Extinguish fires with dry chemical, carbon dioxide, water
spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Coumarin Derivative
Pesticide, Solid, n.o.s.) Keep unnecessary people away; isolate hazard
area and deny entry. Stay upwind; keep out of low areas. Ventilate
closed spaces before entering them. Wear positive pressure breathing
apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site. Move container from fire area if you
can do it without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (DOT 1984,
Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of sodium oxide (Sax 1984, p. 813).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of sodium oxide (Sax 1984, p. 812).
-------
CAS Registry Number: 129-06-6
Page 3 of 4
WARFARIN SODIUM
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 812)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic orally in humans (Sax 1984, p. 812).
Signs and Symptoms of Exposure: (Non-Specific -- Warfarins) May cause
death by hemorrhagic shock. Onset of symptoms occur after a few days or
weeks of repeated ingestion which may cause nose bleeds, bleeding gums,
small reddish spots like a rash, easy bruising, especially of the elbows,
knees, and buttocks, blood in urine and stools, and occasional paralysis
due to a stroke (Gosselin 1984, p. III-395).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Coumarin
Derivative Pesticide, Solid, n.o.s.) Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed, keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
(Non-Specific -- Coumarins) Anticoagulants used as rodenticides (Encyc
Occupat Health and Safety 1983, p. 560)
-------
CAS Registry Number: 129-06-6
Page 4 of 4
WARFARIN SODIUM
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Do not
touch spilled material; stop leak if you can do it without risk. Use
water spray to reduce vapors. For small spills, take up with sand or
other noncombustible absorbent material and place into containers for
later disposal. For small dry spills, with clean shovel place material
into clean, dry container and cover; move containers from spill area. For
large s°pills, dike far ahead of spill for later disposal (DOT 1984, Guide
55).
COMMENTS
Sources searched but no information found:
Weast 1979
Hawley 1981
Hayes 1980
Merck 1983
Farm Chemicals Handbook 1984
NIOSH/OSHA 1978
ACGIH 1983
Oilman 1985
-------
CAS Registry Number: 131-11-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- DIMETHYL PHTHALATE
CAS Registry Number: 131-11-3
Synonyms: 1,2-Benzenedicarboxylic Acid Dimethyl Ester;
1,2-Benzenedicarboxylic Acid, Dimethyl Ester; Avolin; Dimethyl
1,2-Benzenedicarboxylate; Dimethyl Benzeneorthodicarboxylate; Dimethyl-
phthalate; DMF (Insect Repellent); DMP; ENT 262; Fermine; Methyl Phthalate;
Mipax; NTM; Palatinol M; Phthalic Acid Methyl Ester; Phthalic Acid, Dimethyl
Ester; Repeftal; Solvanom; Solvarone; Unimoll DM
Chemical Formula: C..H.-0.
10 10 4
Molecular Weight: 194.19
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 5 mg/m1 (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 5 mg/m3; STEL 10 mg/m3 (*ACGIH 1982)
IDLH: 9,300 mg/m3 (*NIOSH/OSHA 1981)
Other Limits Recommended: Toxicity information: LCj.. inhalation
(mouse) 0.0043 mg/liter (*NIOSH/RTECS 1985) (SUSPECT)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 543°F, 283.7°C (*Merck 1976)
Specific Gravity (H20=l): 1.196 at 15.6°C/15.6°C (*Merck 1976)
Vapor Pressure (mmHg): Less than 0.01 at 20°C (*Merck 1976)
Melting Point: 42°F, 5.5°C (*Merck 1976); 32°F-36°F, 0-2°C for the
commercial product ("Merck 1983)
Vapor Density (AIR=1): 6.69 (*Merck 1976)
Evaporation Rate (Butyl acetate=l): Compared to methyl acetate:
almost zero (-NIOSH/OSHA 1981)
-------
CAS Registry Number: 131-11-3
Page 2 of 3
DIMETHYL PHTHALATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: 0.43 g/100 ml (*Merck 1976)
Appearance and Odor: It is an oily liquid, with slightly aromatic odor
(*Merck 1976) or colorless to pale yellow, viscous liquid, with slight
ester odor (*NIOSH/OSHA 1981).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 295°F (*Merck 1976)
Flammable Limits:
LEL: 1.2% at 295°F (-NIOSH 1981)
DEL: Not Found
Extinguishing Methods: Extinguish with dry chemicals, foam, or carbon
dioxide (*NIOSH/OSHA 1981).
Special Fire Fighting Procedures: Use water to cool fire-exposed
containers (--General Electric Co. 1980, MSDS #430).
Unusual Fire and Explosion Hazards: Water or foam may cause frothing
(*NFPA 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (»0sol 1975)
Conditions to Avoid: Slowly affected by light (»0sol 1975).
Incompatibility (Materials to Avoid): Incompatible with nitrates,
strong oxidizers, strong alkalies, and strong acids (*NIOSH/OSHA 1981).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits acrid smoke and fumes (Sax 1984, p. 1194).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (^General Electric Co.
1980, MSDS #430)
Conditions to Avoid: Not Found
-------
CAS Registry Number: 131-11-3
Page 3 of 3
DIMETHYL PHTHALATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: No (*Merck 1976)
Ingestion: Yes (*Dreisbach 1977)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
slightly toxic. Probable oral lethal dose for humans is 5-15 g/kg, or
between one pint and one quart for a 70 kg (150-lb) person (*Gosselin
1976). It is an eye and gastrointestinal irritant (*Grant 1974, *Rumack
1975 to Present).
Signs and Symptoms of Exposure: Symptoms include burning sensation of
the lips, tongue, and mouth; vomiting; diarrhea; coughing; conjunctivitis;
paralysis and coma (*Dreisbach 1977, *Merck 1976, *Rumack 1975 to
Present). Irritating to mucous membranes; may cause central nervous
system depression after ingestion (*Merck 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Treat as for insect repellants.
Establish respiration. Prevent absorption. Wash exposed areas twice with
soap and water (*Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
Solvent and plasticizer ('"Merck 1976); in solid rocket propellants,
lacquers, coating agents, safety glass, molding powders, perfumes (*Hawley
1977); in chemical lights (*Rumack 1975 to Present); dispersing medium,
plasticizer, hair spray ingredient, insect repellent (*SRI); cosmetic
ingredient (*NIOSH; Current Awareness Listing 1984).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spill material. Avoid inhalation. Wear proper respiratory
protection and eye protection (see Section V above). Remove all ignition
sources; ventilate area of spill or leak. Take up spills by absorbing in
vermiculite, dry sand, earth or a similar material and disposing of in a
secured landfill, or atomizing in a suitable combustion chamber
(-NIOSH/OSHA 1981).
-------
CAS Registry Number: 131-52-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- SODIUM PENTACHLOROPHENATE
CAS Registry Number: 131-52-2
Synonyms: Dow Dormant Fungicide; Dowicide G; Dowicide G-ST; Mystox D;
Napclor-G; J?CP Sodium Salt; PCP-Sodium; Pentachlorophenate Sodium;
Pentachlorophenol Sodium Salt; Pentachlorophenol, Sodium Salt;
Pentachlorophenoxy Sodium; Pentaphenate; Phenol, Pentachloro-, Sodium Salt;
PKHFN; Santobrite; SAPCO 25; Sodium PCP; Sodium Pentachlorophenol; Sodium
Pentachlorophenolate; Sodium Pentachlorophenoxide; Sodium Pentachlorphenate;
Sodium, (Pentachlorophenoxy)-; Weedbeads
Chemical Formula: C.ClcO*Na
O J
Molecular Weight: 288.30
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD, oral (mouse)
164 mj
1985)
164 mg/kg; LC inhalation (mouse) 0.24 mg/liter/2 hours (*NIOSH/RTECS
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 131-52-2
Page 2 of 4
SODIUM PENTACHLOROPHENATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Solubility in Water: 330 g/L at 25°C (''-Worthing 1979); 21.0 % wt/vol
at 5°C; 29.0% wt/vol at 40°C (''-Clayton and Clayton 1981-82)
Appearance and Odor: Tan powder ("Sax 1975); powder, pellets, and
briquettes (*Hawley 1977) with a phenolic odor ("Worthing 1979)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: It is noncombustible (Student 1981, p. 394).
For small fires, use dry chemical, carbon dioxide, water spray, or foam.
For large fires, use water spray, fog, or foam (DOT 1984, Guide 53).
Special Fire Fighting Procedures: Wear self-contained (positive
pressure) breathing apparatus and full protective clothing. Move
container from fire area if possible. Runoff from fire control or
dilution water may cause pollution (DOT 1984, Guide 53).
Unusual Fire and Explosion Hazards: Fire may produce irritating or
poisonous gases (DOT 1984, Guide 53).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of chlorides and sodium oxide (Sax 1984, p. 2446).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 131-52-2
Page 3 of 4
SODIUM PENTACHLOROPHENATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Clayton and Clayton 1981-82)
Skin: Yes (-Clayton and Clayton 1981-82)
Ingestion: Yes ("Clayton and Clayton 1981-82)
Health Hazards (Acute, Delayed, and Chronic): Fine dusts and sprays
are irritating to the eyes and upper respiratory tract. Severe
intoxications, including fatalities, have been reported from uncontrolled
use. This compound causes inflamed gastric mucosa, congestion of the
lungs, edema in the brain, cardiac dilatation, degeneration of the liver
and kidneys (*Encyc Occupat Health and Safety 1971).
Signs and Symptoms of Exposure: Exposure to fine dusts or sprays cause
burning in eyes and painful irritation in upper respiratory tract. If
inhaled, it will induce violent coughing and sneezing. Skin irritation
results from brief exposures ("Clayton and Clayton 1981-82). Symptoms of
. severe systemic intoxication include loss of appetite, respiratory
difficulties, anesthesia, fever, sweating, difficulty in breathing and
rapidly progressive coma (*Encyc Occupat Health and Safety 1971).
Medical Conditions Generally Aggravated by Exposure: Individuals
suffering from kidney and liver diseases have a lowered resistance and
should not be exposed (^Clayton and Clayton 1981-82).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. Remove and isolate contaminated clothing and
shoes at the site (DOT 1984, Guide 53). Bathe and shampoo with soap and
water. Flush chemicals from eyes with copious amounts of water. Prevent
absorption. If the material is ingested, the stomach must be emptied
(-Morgan 1976) .
SECTION VI -- USE INFORMATION
Wood preservative ("'SRI); preservation of cellulose products, textiles,
paints, adhesives, leather, pulp, paper and industrial waste systems
("'Clayton and Clayton 1981-82); contact and pre-emergence herbicide (*Farm
Chemicals Handbook 1981); general disinfectant ("Worthing 1979) and
control of the intermediate snail host of schistosomiasis (Buchel 1983, p.
220)
-------
CAS Registry Number: 131-52-2
Page 4 of 4
SODIUM PENTACHLOROPHENATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Ventilate area of spill. Collect spilled material in most convenient
manner and deposit in sealed containers for later disposal. Liquids
should be absorbed in vermiculite, dry sand, earth, or similar material
(*NIOSH/OSHA 1981). Protective clothing and rubber gloves should be
worn. Nose and mouth must be protected with respirator. Protect eyes
with tight-fitting goggles ("Clayton and Clayton 1981-82). Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Wear self-contained (positive pressure if
available) breathing apparatus and full protective clothing. Do not touch
spilled material; stop leak if you can do so without risk. Small spills:
absorb with sand or other noncombustible absorbent material and place into
containers for later disposal. Small dry spills: with clean shovel,
place material into clean, dry container and cover; move containers from
spill area. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 53).
-------
CAS Registry Number: 140-29-4
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- BENZYL CYANIDE
CAS Registry Number: 140-29-4
Synonyms: (Cyanomethyl)Benzene; 2-Phenylacetonitrile; Acetic acid,
Phenyl-Nitrile; Acetonitrile, Phenyl-; alpha-Cyanotoluene; alpha-Tolunitrile;
Benzeneacetonitrile; Benzyl Nitrile; omega-Cyanotoluene; Phenylacetonitrile;
Toluene, alpha-Cyano; USAF KF-21
Chemical Formula: C0H_N
o /
Molecular Weight: 117.14
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(mouse) 0.10 mg/liter (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 451.4°F, 233.5°C (*Merck 1976)
Specific Gravity (H20=l): 1.0214 at 15°C (*Merck 1976)
Vapor Pressure (mmHg): 1 at 60°C (*Sax 1979)
Melting Point: -10.8°F, -23.8°C (*Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Weast 1979)
Appearance and Odor: Benzyl cyanide is a colorless, oily liquid with
an aromatic odor (-Hawley 1977; *Merck 1976)
-------
CAS Registry Number: 140-29-4
Page 2 of 3
BENZYL CYANIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray, or foam. Large fires: water spray, fog, or foam. Move
container from fire area if you can do it without risk. Fight fire from
maximum distance. Dike fire control water for later disposal; do not
scatter the material (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of cyanide and nitrogen oxides (Sax 1984, p.
2171). Container may explode in heat of fire. Runoff from fire control
water may give off poisonous gases (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Sodium hypochlorite (Sax 1984,
p. 2171)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of cyanide and nitrogen oxides (Sax 1984, p.
2171).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 140-29-4
Page 3 of 3
BENZYL CYANIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 2171)
Skin: Yes (Hawley 1981, p. 122)
Ingestion: Yes (Sax 1984, p. 2171)
Health Hazards (Acute, Delayed, and Chronic): Poisonous. May be fatal
if inhaled, swallowed, or absorbed through skin. Contact may cause burns
to skin and eyes (DOT 1984, Guide 55).
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Organic synthesis, especially penicillin precursors ("Hawley 1977).
Chemical intermediate for amphetamines, phenobarbital, the stimulant,
methyl phenidylacetate, esters as perfumes and flavors (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors. Wear protective clothing (see Section V above).
Do not touch spilled materials; stop leak if you can do it without risk.
Use water spray to reduce vapors. Small spills: take up with sand or
other noncombustible absorbent material and place into containers for
later disposal. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 55).
-------
CAS Registry Number: 140-76-1
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PYRIDINE, 2-METHYL-5-VINYL-
CAS Registry Number: 140-76-1
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 3, p. 423): 2-Methyl-
5-Ethenylpyridine; Pyridine, 5-Etheny1-2-Methyl-; 2-Methyl-5-Vinylpyridine;
2-Picoline, 5-Vinyl-
Chemical Formula: C0H_N
o y
Molecular Weight: 119.18
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC^n inhalation
(rat) 0.189 mg/liter/2 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 358°F, 181°C (Hawley 1981, p. 692)
Specific Gravity (H 0=1): 0.978-0.982 20°C/20°C (Hawley 1981, p. 692)
Vapor Pressure (mmHg): Not Found
Melting Point: Freezing point: 6.3°F, -14.3°C (anhydrous) (Hawley
1981, p. 692)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): .Not Found
Solubility in Water: Not Found
Appearance and Odor: Clear to faintly opalescent liquid (Hawley 1981,
p. 692)
-------
CAS Registry Number: 140-76-1
Page 2 of 4
PYRIDINE, 2-METHYL-5-VINYL-
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 165°F, 73.9°C (TOG) (Hawley 1981, p. 692)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: It is combustible (Hawley 1981, p. 692).
(Non-Specific -- Combustible Liquid, n.o.s.) Extinguish with dry
chemical, carbon dioxide, water spray, fog, or foam (DOT 1984, Guide 27).
Special Fire Fighting Procedures: (Non-Specific -- Combustible Liquid,
n.o.s.) Wear self-contained (positive pressure if available) breathing
apparatus and full protective clothing. Isolate for 1/2 mile in all
directions if tank car or truck is involved in fire. Move container from
fire area if you can do so without risk. Spray cooling water on
containers that are exposed to flames until well after fire is out. For
massive fire in cargo area, use unmanned hose holder or monitor nozzles;
if this is impossible, withdraw from area and let fire burn. Withdraw
immediately in case of rising sound from venting safety device or any
discoloration of tank due to fire (DOT 1984, Guide 27).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of nitrogen oxides (Sax 1984, p. 1944). (Non-Specific
-- Combustible Liquid, n.o.s.) Flammable/combustible material; may be
ignited by heat, sparks, or flames. Vapors may travel to a source of
ignition and flash back. Container may explode in heat of fire (DOT 1984,
Guide 27).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of nitrogen oxide (Sax 1984, p. 1944).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 140-76-1
Page 3 of 4
PYRIDINE, 2-METHYL-5-VINYL-
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1944)
Skin: Yes (Sax 1984, p. 1944)
Ingestion: Yes (Sax 1984, p. 1944)
Health Hazards (Acute, Delayed, and Chronic): This material is
moderately toxic by ingestion, inhalation, and absorption through the skin
(Sax 1984, p. 1944).
Signs and Symptoms of Exposure: (Non-Specific -- Combustible Liquid,
n.o.s.) Vapors may cause dizziness or suffocation (DOT 1984, Guide 27).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Combustible
Liquid, n.o.s.) Move victim to fresh air; call emergency medical care.
If not breathing, give artificial respiration. If breathing is difficult,
give oxygen. In case of contact with material, immediately flush eyes
with running water for at least 15 minutes. Wash skin with soap and
water. Remove and isolate contaminated clothing and shoes at the site
(DOT 1984, Guide 27).
SECTION VI -- USE INFORMATION
Used as a monomer for resins; oil additive, ore flotation agent; and dye
acceptor (Hawley 1981, p. 692).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Combustible Liquid, n.o.s.) Keep unnecessary people
away; isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Wear self-contained breathing apparatus and full protective
clothing. Shut off ignition sources; no flares, smoking, or flames in
hazard area. Stop leak if you can do so without risk. Use water spray to
reduce vapors. Absorb spills with sand or noncombustible absorbent
material. For large spills dike far ahead (DOT 1984, Guide 27).
-------
CAS Registry Number: 140-76-1
Page 4 of 4
PYRIDINE, 2-METHYL-5-VINYL-
COMMENTS
Sources searched but no information found:
ACGIH 1983
NIOSH/OSHA 1978
Weast 1979
Merck 1983
Student 1981
CHRIS 1978
Doull 1980
Arena 1979
Gosselin 1984
Encyc Occupat Health and Safety 1983
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
Physicians' Desk Reference 1985
Gilman 1985
Clayton and Clayton 1981-82
NFPA 1984
Weiss 1980
-------
CAS Registry Number: 141-66-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DICROTOPHOS
CAS Registry Number: 141-66-2
Synonyms: 3-(Dimethoxyphosphinyloxy)-N,N-Dimethyl-cis-Crotonamide;
3-(Dimethylamino)-l-Methyl-3-Oxo-l-Propenyl Dimethyl Phosphate (E)-Isomer;
3-Dimethoxyphosphinyloxy-N,N-Dimethylisocrotonamide; 3-Hydroxy-N,N-
Dimethyl-cis-Crotonamide Dimethyl Phosphate; 3-Hydroxydimethyl Crotonamide
Dimethyl Phosphate; Bidrin; C 709; Carbicron; Carbomicron; Ciba 709,
Cis-2-Dimethylcarbamoyl-l-Methylvinyl Dimethylphosphate; Crotonamide,
3-Hydroxy-N,N-Dimethyl-, cis-, Dimethyl Phosphate; Dimethyl (E)-Z-Dimethyl-
Carbamoyl-1-Methylvinyl Phosphate; Dimethyl l-Dimethylcarbamoyl-l-Propen-2-yl
Phosphate; Dimethyl 2-Dimethylcarbamoyl-l-Methylvinyl Phosphate; Phosphoric
Acid, Dimethyl Ester, Ester with cis-3-Hydroxy-N,N-Dimethylcrotonamide;
Dimethyl Phosphate Ester with 3-Hydroxy-N,N-Dimethylcrotonamide; Dimethyl
Phosphate of 3-Hydroxy-NsN-Dimethyl-cis-Crotonamide; Ektafos; ENT 24,482;
Karbicron; 0,0-Dimethyl 0-(N,N-Dimethylcarbamoyl-l-Methylvinyl) Phosphate;
0,0-Dimethyl 0-(l,4-Dimethyl-3-Oxo-4-Azapent-l-enyl) Phosphate; Oleobidrin;
Phosphoric acid, Dimethyl Ester, Ester with (E)-3-Hydroxy-N,N-Dimethyl-
crotonamide; SD 3562; Shell SD-3562; Phosphoric Acid, 3-(Dimethylamino)-l-
Methyl-3-oxo-l- Propenyl Dimethyl Ester, (E)-; Crotonamide, 3-Hydroxy-N,N-
Dimethyl-, Dimethyl Phosphate, cis-; Crotonamide, 3-Hydroxy-N,N-Dimethyl-,
Dimethyl Phosphate, (E)-
Chemical Formula: C-H.^NO..?
o lb o
Molecular Weight: 237.21
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.25 mg/m3 (skin) (*ACGIH 1980)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat) 0.09 mg/liter/4 hours (*NIOSH/RTECS 1985)
-------
CAS Registry Number: 141-66-2
Page 2 of 4
DICROTOPHOS
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 752°F, 400°C (*Merck 1976)
Specific Gravity (H20=l): 1,216 at 15°C/15°C (*Merck 1976)
Vapor Pressure (mmHg): 1 x 10"5 at 20°C (Worthing 1983, p. 190)
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (*Sax 1979)
Appearance and Odor: Dicrotophos is a yellow to brown liquid with a
mild ester odor (*Spencer 1973; '''Worthing 1979).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Above 175°F (*Farm Chemicals Handbook 1981)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphorus Pesticide,
Liquid, n.o.s.) Extinguish with dry chemical, carbon dioxide, water
spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) Move container from fire area if you can do so
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material. Wear positive pressure
breathing apparatus and special protective clothing (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) This material may burn but does not ignite
readily. Container may explode in heat of fire. Fire and runoff from
fire control water may produce irritating or poisonous gases (DOT 1984,
Guide 55).
-------
CAS Registry Number: 141-66-2
Page 3 of 4
DICROTOPHOS
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Keep away from heat and open flame (*Farm
Chemicals Handbook 1981).
Incompatibility (Materials to Avoid): Rapidly hydrolyzes in acid or
alkali (*Sunshine 1969).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Hayes 1982, pp. 361-362)
Skin: Yes (Hayes 1982, pp. 361-362)
Ingestion: Yes (Hayes 1982, pp. 361-362)
Health Hazards (Acute, Delayed, and Chronic): It is extremely toxic.
Probable human oral lethal dose is 5 to 50 tng/kg, 7 drops to one
teaspoonful for a 70 kg (150 Ib.) person. Closely related in toxicity to
azodrin (-Gosselin 1976).
Signs and Symptoms of Exposure: Typical symptoms of organophosphate
poisoning include nausea, vomiting, abdominal cramps, diarrhea, excessive
salivation, headache, giddiness, blurring and dimness of vision, loss of
muscle coordination, weakness, difficulty breathing, convulsion, coma, and
death (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 141-66-2
Page 4 of 4
DICROTOPHOS
SECTION VI -- USE INFORMATION
Used to control sucking, boring, and chewing pests on rice, cotton,
coffee, apples, and other crops. Effective on ornamentals, trees, and
shrubs for aphids, leaf hoppers, and scale insects (^Worthing 1979;
*Spencer 1973; *SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Do not touch
spilled material; stop leak if you can do so without risk. Use water
spray to reduce vapors. Small spills: absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. Small dry spills: with clean shovel place material into clean,
dry container and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal. Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site (DOT 1984, Guide 55).
-------
CAS Registry Number: 143-33-9
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- SODIUM CYANIDE (Na(CN))
CAS Registry Number: 143-33-9
Synonyms: Cyanide of Sodium; Cyanogran; Cymag; Hydrocyanic Acid, Sodium
salt; Sodium Cyanide, Solid (DOT)
Chemical Formula: NaCN
Molecular Weight: 49.01
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 5 mg (Cyanide)/m3 (Skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 5 mg (Cyanide)/m3 (*ACGIH 1983)
IDLH: 50 mg/m3 (NIOSH/OSHA 1978, p. 74)
Other Limits Recommended: The recommended upper limit for occupational
exposure to cyanide salts is 5 mg (Cyanide)/m3/10 min (*NIOSH/RTECS
1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 2725°F, 1496°C (-Weast 1979)
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): 1 at 817°C (*Clayton and Clayton 1981-82)
Melting Point: 1047°F, 564°C (*Weast 1979)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 82 g/100 cc at 35°C (*Weast 1979)
Appearance and Odor: White solid in form of granules, flakes, or eggs
(resembling chicken eggs) (*NFPA 1978); colorless cubes ("Weast 1979);
odorless when perfectly dry but emits odor of hydrogen cyanide when damp
(•''Merck 1983)
-------
CAS Registry Number: 143-33-9
Page 2 of 4
SODIUM CYANIDE (Na(CN))
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not combustible (NFPA 1984, p. 49-81)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Use water ("NFPA 1978). Use dry chemical,
carbon dioxide, water spray, or foam for small fires, water spray, fog, or
foam for large fires (*DOT 1984).
Special Fire Fighting Procedures: Full protective clothing including
self-contained breathing apparatus, rubber gloves, boots, and bands around
legs, arms, and waist should be provided. No skin surface should be
exposed. Normal fire fighting procedures may be used ("NFPA 1978). Fight
fire from maximum distance. Move container from area if you can do it
without risk. Dike fire control water for later disposal. Do not scatter
the material ('''DOT 1984) .
Unusual Fire and Explosion Hazards: Sodium cyanide is not combustible
itself, but contact with acids releases highly flammable hydrogen cyanide
gas (""NFPA 1978). Fire may produce irritating or poisonous gases. Runoff
from fire control water may give off poisonous gases. Container may
explode in the heat of fire (*DOT 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (-NFPA 1978)
Conditions to Avoid: Avoid contact with acids ("NFPA 1978).
Aqueous solutions rapidly decompose (*Hawley 1977).
Incompatibility (Materials to Avoid): Strong oxidizers such as
nitrates and chlorates; acids and acid salts (NIOSH/OSHA 1978, p. 74)
Hazardous Decomposition or Byproducts: Hydrogen cyanide (*NFPA 1978)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 143-33-9
Page 3 of 4
SODIUM CYANIDE (Na(CN))
SECTION V -- HEALTH HAZARD DATA (Continued)
Routes of Entry: Inhalation: Yes (-Clayton and Clayton 1981-82)
Skin: Yes (*Clayton and Clayton 1981-82)
Ingestion: Yes (-Clayton and Clayton 1981-82)
Health Hazards (Acute, Delayed, and Chronic): Super toxic; probable
oral lethal dose in humans is less than 5 rag/kg or a taste (less than 7
drops) for a 70 kg (150 Ib.) person (-'Gosselin 1976). Sodium cyanide is
poisonous and may be fatal if inhaled, swallowed or absorbed through the
skin. Contact with sodium cyanide may cause burns to skin and eyes (''"DOT
1984).
Signs and Symptoms of Exposure: Sodium cyanide produces all typical
symptoms of other sources of cyanide ion. Acute symptoms can be produced
by inhalation, skin absorption, and ingestion ("Clayton and Clayton
1981-82). Massive doses may produce sudden loss of consciousness and
prompt death from respiratory arrest. Smaller doses may still be lethal
but illness may be prolonged for 1-2 hours. Upon ingestion, a bitter,
acrid, burning taste is sometimes noted, followed by a feeling of
constriction or numbness in the throat ('-Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Individuals with
chronic diseases of the kidneys, respiratory tract, skin, or thyroid are
at greater risk of developing toxic cyanide effects (*Encyc Occupat Health
and Safety 1983).
Emergency and First Aid Procedures: Avoid mouth-to-mouth resuscitation
(*Rumack 1975 to Present). Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (-DOT 1984).
SECTION VI -- USE INFORMATION
Sodium cyanide is used as a fumigant (-Merck 1983), a rodenticide (^Morgan
1982), in cleaning metals, and in the manufacturing of dyes and pigments,
as a chelating compound ("-Hawley 1977), as a component of electroplating
solutions, as a component of salts for case hardening steel, and as an
agent for extraction of gold and silver from ores (-SRI).
-------
CAS Registry Number: 143-33-9
Page 4 of 4
SODIUM CYANIDE (Na(CN))
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Evacuate the area immediately. Impervious protective clothing as well as
suitable respiratory protective equipment are required to enter spill .
areas (*Encyc Occupat Health and Safety 1983). Do not touch spilled
material; stop leak if you can do it without risk. Use water spray to
reduce vapors. Small spills: take up with sand or other noncombustible
absorbent material and place into containers for later disposal. Small
dry spills: with clean shovel place material into clean, dry container
and cover; move containers from spill area, Large spills: dike far ahead
of spill for later disposal (*DOT 1984).
-------
CAS Registry Number: 144-49-0
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- FLUOROACETIC ACID
CAS Registry Number: 144-49-0
Synonyms: Acetic Acid, Fluoro-; 2-Fluoroacetic Acid; alpha-Fluoroacetic
Acid; Cymonic Acid; FAA; Fluoroethanoic Acid; Gifblaar Poison; HFA; MFA;
Monofluoroacetic Acid
Chemical Formula: C H FO
£ J t*
Molecular Weight: 78.04
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 0.05 mg/m3 (for sodium salt) (OSHA 1984, p. 663)
ACGIH TLV: TWA 0.05 mg/m3; STEL 0.15 mg/m3 (for sodium salt)
(*ACGIH 1980)
IDLH: Not Found
Other Limits Recommended: IDLH for sodium salt: 5 mg/m3 (NIOSH/OSHA
1978, p. 166). Toxicity :
mg/kg (*NIOSH/RTECS 1985)
1978, p. 166). Toxicity information: ^cn °ral (guinea pig) 0.468
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 329°F, 165°C (*Weast 1979)
Specific Gravity (H 0=1): 1.3693 at 97°F, 36°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: 95.4°F, 35.2°C (*Weast 1979)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (Weast 1983, p. 597)
Appearance and Odor: Colorless crystals (*Hawley 1977)
-------
CAS Registry Number: 144-49-0
Page 2 of 3
FLUOROACETIC ACID
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Burns (*Merck 1976)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Small fires: use dry chemical, carbon dioxide,
water spray, or foam. For large fires, use water spray, fog, or foam (DOT
1984, Guide 59).
Special Fire Fighting Procedures: Stay upwind; keep out of low areas.
Wear self-contained, positive pressure breathing apparatus and full
protective clothing. Move container from fire area. Cool containers that
are exposed to flames with water from the side until well after fire is
out (DOT 1984, Guide 59).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits highly toxic fumes of fluorine containing compounds (*Sax 1979).
Some of these materials may burn but none ignite readily. These materials
may ignite combustibles (wood, paper, oil, etc.) (DOT 1984, Guide 59).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Encyc Occupat Health and Safety 1971)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes of fluorine containing compounds (*Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Sax 1975)
-------
CAS Registry Number: 144-49-0
Page 3 of 3
FLUOROACETIC ACID
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): This material is very
toxic; ingestion of small quantities may cause death (*Sax 1975).
Signs and Symptoms of Exposure: The major symptoms of fluoroacetic
acid poisoning include severe epileptiform convulsions alternating with
coma and depression; death may result from asphyxia during convulsion or
from respiratory failure. Cardiac irregularities, such as ventricular
fibrillation and sudden cardiac arrest, nausea, vomiting, excessive
salivation, numbness, tingling sensations, epigastric pain, mental
apprehension, muscular twitching, low blood pressure, and blurred vision
may also occur ("Encyc Occupat Health and Safety 1971).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush" skin or eyes with running water for at least 15
minutes. Remove and isolate contaminated clothing and shoes at the site.
Keep victim quiet and maintain normal body temperature (DOT 1984, Guide
59).
SECTION VI -- USE INFORMATION
Rodenticide (Hawley 1981, p. 470). The sodium salt of this material is
used as a rodent poison (*Patty 1963).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material. Stop leak if you can do so without risk.
Stay upwind; keep out of low areas. Use water spray to reduce vapors.
Wear self-contained, positive pressure breathing apparatus and full
protective clothing. For small spills, take up with sand or other
noncombustible absorbent material and place into containers for later
disposal. For large spills, dike spill for later disposal (DOT 1984,
Guide 59).
-------
CAS Registry Number: 149-74-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- DJCHLOROMETHYLPHENYLSILANE
CAS Registry Number: 149-74-6
Synonyms: Methylphenyldichlorosilane; Phenylmethyldichlorosilane; Silane,
Dichloromethylphenyl-
Chemical Formula: C_H0Cl.Si
/ o 2
Molecular Weight: 191.14
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(mouse) 0.2 mg/liter/2 hours (-NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 401°F, 205°C (Hawley 1981, p. 688)
Specific Gravity (H20=l): 1.19 (*Hawley 1977)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Colorless liquid (*Hawley 1977)
-------
CAS Registry Number: 149-74-6
Page 2 of 3
DICHLOROMETHYLPHENYLSILANE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 83°F (28°C) (*Hawley 1977) (SUSPECT)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: For small fires, use dry chemical, carbon
dioxide, water spray or foam. For large fires, use water spray, fog, or
foam (DOT 1984, Guide 29).
Special Fire Fighting Procedures: Isolate for 1/2 mile in all
directions if tank car or truck is involved in a fire. Wear
self-contained (positive pressure) breathing apparatus with full
protective clothing. Do not get water inside container (DOT 1984, Guide
29).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of chlorine-containing compounds (Sax 1984, p. 951).
Flammable/combustible material; may be ignited by heat, sparks, or
flames. Vapors may travel to a source of ignition and flash back.
Container may explode in heat of fire. Vapor explosion hazard indoors,
outdoors or in sewers. Runoff to sewer may create fire or explosion
hazard. Fire may produce irritating or poisonous gases (DOT 1984, Guide
29).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Reacts strongly with oxidizing
materials (*Hawley 1977)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of chlorine-containing compounds (Sax 1984, p. 951)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 149-74-6
Page 3 of 3
DICHLOROMETHYLPHENYLSILANE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): The chemical is toxic
and is an irritant (*Hawley 1977). Contact may cause burns to the skin
and eyes.(DOT 1984, Guide 29).
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material;
immediately flush skin or eyes with running water for at least 15
minutes. Keep victim quiet and maintain normal body temperature (DOT
1984, Guide 29).
SECTION VI -- USE INFORMATION
Used in the manufacture of silicones ("Hawley 1977); and as a chemical
intermediate for silicone fluids, resins and elastomers ("SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away. Stay upwind. Stay out of low areas. Wear
self-contained (positive pressure if available) breathing apparatus and
full protective clothing. Shut off ignition sources; no flares, smoking
or flames in hazard area. Do not touch spilled material; stop leak if you
can do so without risk. Use water spray to reduce vapors; do not get
water inside container. Small spills: absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 29).
-------
CAS Registry Number: 151-38-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- METHOXYETHYLMERCURIC ACETATE
CAS Registry Number: 151-38-2
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 657) Mercury,
(Acetato)(2-Methoxyethyl)-; Acetato(2-Methoxyethyl)Mercury; Landisan; MeEHg;
MEMA; Mercuran; Mercury, Acetoxy(2-Methoxyethyl)-; Radosan; Methoxyethyl
Mercuric Acetate
(Farm Chemicals Handbook 1984, p. CHS) Panogen
Chemical Formula: C H HgO
Molecular Weight: 318.74
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 10 vig (Hg)/m3; Ceiling 40 yg (Hg)/m3
(NIOSH/RTECS 1983, p. 657)
ACGIH TLV: TWA 10 yg (Hg)/m3; STEL 30 vg (Hg)/m3 (skin)
(NIOSH/RTECS 1983, p. 657)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (rat) 16
mg/kg (^NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 151-38-2
Page 2 of 4
METHOXYETHYLMERCURIC ACETATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Soluble (Sax 1984, p. 1776)
Appearance and Odor: Crystals (Sax 1984, p. 1776)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This is an alky 1 mercury pesticide (Hayes 1982,
p. 20). Small fires: dry chemical, carbon dioxide, water spray, or
foam. Large fires: water spray, fog, or foam. Move container from fire
area if you can do so without risk. Fight fire from maximum distance.
Dike fire control water for later disposal; do not scatter the material.
Fire may produce irritating or poisonous gases. Runoff from fire control
water may give off poisonous gases. Runoff from fire control or dilution
water may cause pollution (DOT 1984, Guide 55).
Special Fire Fighting Procedures: This is an alky 1 mercury pesticide
(Hayes 1982, p. 20). Keep unnecessary people away; isolate hazard area
and deny entry. Stay upwind; keep out of low areas. Ventilate closed
spaces before entering them. Wear positive pressure breathing apparatus
and special protective clothing. Remove and isolate contaminated clothing
at the site. If water pollution occurs, notify appropriate authorites
(DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of mercury (Sax 1984, p. 1776). This material may burn
but does not ignite readily. Container may explode in heat of fire (DOT
1984, Guide 55). <•
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
-------
CAS Registry Number: 151-38-2
Page 3 of 4
METHOXYETHYLMERCURIC ACETATE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits toxic fumes of mercury (Sax 1984, p. 1776).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Encyc Occupat Health and Safety
1983, p. 1337)
Skin: Yes (Non-Specific -- Mercury Compounds)
(Hayes 1982, pp. 15-16)
Ingestion: Yes (Encyc Occupat Health and Safety
1983, p. 1337)
Health Hazards (Acute, Delayed, and Chronic): Highly toxic (Hawley
1981, p. 664). Target.organs are brain and central nervous system (Hayes
1982, pp. 18-19). Inhalation can cause lung damage; ingestion can cause
kidney damage. Women of childbearing age should avoid exposure (Encyc
Occupat Health and Safety 1983, p. 1337).
Signs and Symptoms of Exposure: This is an alkyl mercury pesticide.
Patients complain of headache, paresthesia of tongue, lips, fingers, and
toes, a metallic taste in mouth, gastrointestinal disturbances, gas, and
diarrhea. Nervous system symptoms may appear first after a relatively
slight exposure or have a latency period of several weeks. These symptoms
include fine tremors of extended hands, loss of side vision, slight loss
of coordination, loss of coordination of speech, writing and gait.
Uncoordination may progress to loss of ability to control voluntary
movements. Irritability and bad temper may progress to mania. Stupor or
coma may develop. Blisters or dermatitis may be present on skin.
Symptoms persist for years even in cases of mild exposure (Hayes 1982, pp.
20-21).
Medical Conditions Generally Aggravated by Exposure: Women of
childbearing age and persons with eczema, renal or neurological disorders
should not be exposed to mercurials (Encyc Occupat Health and Safety,
1983, p. 1337).
-------
CAS Registry Number: 151-38-2
Page 4 of 4
METHOXYETHYLMERCURIC ACETATE
SECTION V -- HEALTH HAZARD DATA (Continued)
Emergency and First Aid Procedures: This is an alkyl mercury pesticide
(Hayes 1982, p. 20). Move victim to fresh air; call emergency medical
care. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Used as a pesticide in seed treatment for cotton and small grains. It is
no longer approved for this use (Farm Chemicals Handbook 1984, pp.
C144-148). It exhibits high fungicidal activity against leaf stripe of
barley, stinking smut of wheat, snow mold of rye; against seedling
diseases in beets and legumes, and for dressing "seed" potatoes, bulbs,
and tubers (Buchel 1983, pp. 250-51). Not registered as a pesticide in
the U.S. (USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
This is an alkyl mercury pesticide (Hayes 1982, p. 20). Wear protective
clothing and positive pressure breathing apparatus. Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. Small
dry spills: with clean shovel place material into clean, dry container
and cover; move containers from spill area. Large spills: dike far ahead
of spill for later disposal (DOT 1984, Guide 55).
COMMENTS
Sources searched but no information found:
Weast 1979
ACGIH 1983
NIOSH/OSHA 1978
Weiss 1980
Merck 1983
Clayton and Clayton 1981-82
Student 1981
-------
CAS Registry Number: 151-50-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- POTASSIUM CYANIDE
CAS Registry Number: 151-50-8
Synonyms: Cyanide of Potassium; Hydrocyanic Acid, Potassium Salt;
Potassium Cyanide (KCN)
Chemical Formula: KCN
Molecular Weight: 65.11
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 5 mg/m3 as cyanide (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 5 mg/m3 as cyanide (skin) (*ACGIH 1980)
IDLH: 50 mg/m3 (NIOSH/OSHA 1978, p. 74)
Other Limits Recommended: NIOSH Occupational Exposure Recommended
Standard -- Air Ceiling 5 mg/m3 as cyanide, 10 minutes (*NIOSH/RTECS
1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 1.52 at 16°C (Weast 1978, p. B150)
Vapor Pressure (mmHg): Not Found
Melting Point: 1173°F, 634°C (-Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble in 2 parts cold water or 1 part boiling
water (-Merck 1976)
Appearance and Odor: White granular powder or lumps with faint odor of
bitter almonds (-Merck 1976,* Hawley 1977)
-------
CAS Registry Number: 151-50-8
Page 2 of 4
POTASSIUM CYANIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not flammable (*NFPA 1978)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Water may be used on fire in an area containing
potassium cyanide (*NFPA 1978). Extinguish with dry chemical, carbon
dioxide, water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Wear full protective clothing (-NFPA
1978). Wear positive pressure breathing apparatus and special protective
clothing. Move container from fire area if you can do it without risk.
Fight fire from maximum distance. Dike fire control water for later
disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Contact with acid releases highly
flammable hydrogen cyanide gas (*NFPA 1978) . Moisture may cause this
material to volatilize as hydrogen cyanide (*Peer Review Committee).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 766)
Conditions to Avoid: Avoid contact with acids (see Section III
above)
Incompatibility (Materials to Avoid): Reacts with acids to produce
hydrogen cyanide gas (*NFPA 1978). Reacts with strong oxidizers such as
nitrates and chlorates (NIOSH/OSHA 1978, p. 74); nitrogen trichloride;
perchloryl fluoride; sodium nitrate; acids; alkaloids; chloral hydrate;
iodine (Sax 1984, p. 2273).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of cyanide and nitrogen oxides (Sax 1984, p.
2273).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 151-50-8
Page 3 of 4
POTASSIUM CYANIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Yes (--Merck 1976)
Ingestion: Yes (*Merck 1976)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or
less than a taste (7 drops) for a 150 Ib. person (*Gosselin 1976). It is
an eye and skin irritant (*Grant 1974, *Encyc Occupat Health and Safety
1971). Poisonous in very small quantities; a taste is lethal (*Gosselin
1984).
Signs and Symptoms of Exposure: Exposure to potassium cyanide can
cause weakness, headache, confusion, nausea, vomiting, increased rate of
respiration or slow, gasping respiration, scarlet rash, itching,
blindness, odor of bitter almonds, rise in blood pressure, irregular
pulse, giddiness, and anxiety (^Clayton and Clayton 1981-82, "Gosselin
1976, *Encyc Occupat Health and Safety 1971, *Grant 1979).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Potassium cyanide is used for electroplating, steel hardening, extraction
of gold and silver from ores, manufacture of some chemicals, and
fumigation (*Encyc Occupat Health and Safety 1971).
-------
CAS Registry Number: 151-50-8
Page 4 of 4
POTASSIUM CYANIDE
SECTION VII'-- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid water. Cover spilled material with alkali or sodium thiosulfate
(-Rumack 1975 to Present). Wear full protective clothing (*NFPA 1978).
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Ventilate closed spaces before entering
them. Wear positive pressure breathing apparatus. Do not touch spilled
material; stop leak if you can do it without risk. Use water spray to
reduce vapors. Small spills: take up with sand or other noncombustible
absorbent material' and place into containers for later disposal. Small
dry spills: with clean shovel place materials into clean, dry container
and cover; move containers from spill area. Large spills: dike far ahead
of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 151-56-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -~ ETHYLENEIMINE
CAS Registry Number: 151-56-4
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 291) Aminoethylene;
Azacyclopropane; Azirane; Aziridine; IH-Azirine, dihydro-; Dihydroazirene;
Dimethyleneimine; Dimethylenimine; El; Ethylenimine; ENT-50324, Ethylimine.
Chemical Formula: C2H5N
Molecular Weight: 43.07
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 1 mg/m3 (skin) (NIOSH 1983, p. 292)
ACGIH TLV: TWA 1.0 mg/m3 (skin) (ACGIH 1983, p. 20)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC, inhalation
low
(guinea pig) 0.044 mg/liter/8 hours ('''NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 131-133°F, 55-56°C (Clayton and Clayton 1981-82,
p. 2673)
Specific Gravity (H 0=1): 0.8321 at 20°C (Clayton and Clayton
1981-82, p. 2673)
Vapor Pressure (mmHg): 160 at 20°C (Clayton and Clayton 1981-82,
p. 2673)
Melting Point: -98°F, -72°C (Freezing Point) (Clayton and Clayton
1981-82, p. 2673)
Vapor Density (AIR=1): 1.48 (Clayton and Clayton 1981-82, p. 2673)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (Merck 1983, p. 3744)
-------
CAS Registry Number: 151-56-4
Page 2 of 4
ETHYLENEIMINE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless, mobile fluid with a strong ammoniacal
odor (Clayton and Clayton 1981-82, p. 2673; Merck 1983, p. 3744)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 12°F (CC) (NFPA 1984, p. 325M-51)
Flammable Limits:
LEL: 3.6% (NFPA 1984, p. 325M-51)
UEL: 46% (NFPA 1984, p. 325M-51)
Extinguishing Methods: Dry chemical, alcohol foam, or carbon dioxide
are useful for small fires. For large fires: water spray, fog or foam
(DOT 1984, Guide 30).
Special Fire Fighting Procedures: Do not extinguish fire unless flow
can be stopped; use water in flooding quantities as a fog. Solid streams
of water may be ineffective. Apply water from as far a distance as
possible (Student 1981, p. 236). If tank car or truck is involved in
fire, isolate the surrounding area in a 1/2 mile radius (DOT 1984, Guide
30).
Unusual Fire and Explosion Hazards: Irritating vapors are generated
when heated. Vapor is heavier than air and may travel a considerable
distance to a source of ignition and flash back. May polymerize in fires
with evolution of heat and container rupture (Weiss 1980, p. 443). Runoff
to sewer may create fire or explosion hazard (DOT 1984, Guide 30).
Ethyleneimine vapors are not inhibited and may form polymers in vents or
flame arresters, resulting in stopping of the vents (*NFPA 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 443)
Conditions to Avoid: If heated under pressure, instability may
result (Weiss 1980, p. 443).
Incompatibility (Materials to Avoid): Acids (Weiss 1980, p. 443);
sodium hypochlorite (*Bretherick 1979).
Hazardous Decomposition or Byproducts: Toxic oxides of nitrogen are
produced during combustion (Student 1981, p. 236). Upon treatment with
sodium hypochlorite, it gives off the explosive compound 1-chloroazidine
(*Bretherick 1979).
-------
CAS Registry Number: 151-56-4
Page 3 of 4
ETHYLENEIMINE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Yes (Merck 1983, p. 551)
May Not Occur:
Conditions to Avoid: Avoid contact with silver or aluminum.
Explosive polymerization may occur upon contact with acids (Weiss
1980, p. 443). Polymerization is catalyzed by carbon dioxide
(-Bretherick 1979).
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Weiss 1980, p. 443)
Skin: Yes (Weiss 1980, p. 443)
Ingestion: Yes (Weiss 1980, p. 443)
Health Hazards (Acute, Delayed, and Chronic): Ethyleneimine is
classified as extremely toxic with a probable oral lethal dose of 5-50
mg/kg which is approximately 7 drops to 1 teaspoonful for a 70 kg (150
Ib.) person ("Gosselin 1976). Ethyleneimine gives inadequate warning when
over-exposure is by inhalation or skin absorption. It is a severe
blistering agent, causing third degree chemical burns of the skin. Also,
it has a corrosive effect on mucous membranes and may cause scarring of
the esophagus. It is corrosive to eye tissue and may cause permanent
corneal opacity and conjunctival scarring (Weiss 1980, p. 443). Severe
exposure may result in overwhelming pulmonary edema. Renal damage has
been described (Gosselin 1984, p. 11-207). Hemorrhagic congestion of all
internal organs has been observed (Clayton and Clayton 1981-82, p. 2674).
Signs and Symptoms of Exposure: Symptoms include tearing and burning
of the eyes, sore throat, nausea, vomiting, coughing (may persist for
weeks or months) and a slow healing dermatitis due to severe blistering
(Gosselin 1984, p. 11-207; Weiss 1980, p. 443).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. Remove and isolate contaminated clothing and shoes at the site.
In case of contact with ethyleneimine, immediately flush skin or eyes with
running water for at least 15 minutes (DOT 1984, Guide 30).
-------
CAS Registry Number: 151-56-4
Page 4 of 4
ETHYLENEIMINE
SECTION VI -- USE INFORMATION
Products of polymerization of ethyleneimine are used in the paper industry
and as flocculation aids (*Encyc Occupat Health and Safety 1971). Used in
textile chemicals, adhesives, binders, petroleum refining chemicals, fuels
and lubricants, coating resins, varnishes, lacquers, agricultural
chemicals, cosmetics, ion exchange resins, photographic chemicals and
surfactants (*Clayton and Clayton 1981-82).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Wear full protective clothing (NFPA 1984, p. 325M-48). Avoid breathing
vapors. Keep upwind. Avoid bodily contact with the material. Do not
handle broken packages without protective equipment. Wash away any
material which may have contacted the body with copious amounts of water
or soap and water (Student 1981, p. 237). Keep unnecessary people away,
isolate hazard area and deny entry. Stay upwind, keep out of low areas.
Wear positive pressure breathing apparatus and full protecting clothing
(DOT 1984, Guide'30).
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CAS Registry Number: 152-16-9
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DIPHOSPHORAMIDE, OCTAMETHYL-
CAS Registry Number: 152-16-9
Synonyms: Pyrophosphoramide, Octamethyl-; Bis(bisdimethylaminophosphonous)
anhydride; Bis(dimethylamino)phosphoric anhydride; Bis-N,N,N',N*-tetramethyl-
phosphorodiamidic anhydride; Lethalaire G-59; Octamethyl pyrophosphortetramide;
Octamethyl tetramido pyrophosphate; Octamethyldiphosphoramide; Octamethyl-
pyrophosphoramide; Octamethylpyrophosphoric acid tetramide; OMPA; Ompacide;
Ompatox; Ompax; Pestox III; Schradan; Pyrophosphoric acid
octamethyltetraamide; Pyrophosphoryltetrakisdimethylamide; Scharadan; Systam;
Systophos; Sytam; Tetrakisdimethylaminophosphonous anhydride
Chemical Formula: C0H0/N.P000
8 24 4 2 3
Molecular Weight: 286.26
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Maximum permissible atmospheric
concentration of this compound in work places is estimated 'to be 0.5
mg/m3 (*Clarke 1975). Toxicitv information: LC.. inhalation (rat)
0.008 mg/liter for 4 hours (*NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 248-257°F, 120-125°C at 0.5 mmHg (*Merck 1976)
y
Specific Gravity (H 0=1): 1.09 at 25°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 0.001 at 25°C (^Worthing 1979)
Melting Point: 57-68°F, 14-20°C (-Worthing 1979)
Vapor Density (AIR=1): Not Found
-------
CAS Registry Number: 152-16-9
Page 2 of 4
DIPHOSPHORAMIDE, OCTAMETHYL-
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (*Merck 1976)
Appearance and Odor: Viscous liquid (*Merck 1976); dark brown viscous
liquid (^Worthing 1979). Odor information was not found.
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphorous Liquid
Pesticides) Do not extinguish fire unless flow can be stopped. Use water
in flooding quantities as fog. Solid streams of water may be
ineffective. Cool all affected containers with flooding quantities of
water. Apply water from as far a distance as possible. Use alcohol foam,
carbon dioxide, or dry chemical (*Student 1981).
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: When heated to decomposition, it
can emit highly toxic fumes of oxides of phosphorous (*Sax 1979).
SECTION IV -.- REACTIVITY DATA
Stability: Unstable:
Stable: Yes ('^Worthing 1979)
Conditions to Avoid: Hydrolyzed under acid conditions to
dimethylamine and orthophosphoric acid (^Worthing 1979)
Incompatibility (Materials to Avoid): Decomposes when mixed with acid
(^Worthing 1979).
Hazardous Decomposition or Byproducts: Decomposes when mixed with acid
(^Worthing 1979). Emits highly toxic fumes of oxides of phosphorous when
heated to decomposition (*Sax 1979).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 152-16-9
Page 3 of 4
DIPHOSPHORAMIDE, OCTAMETHYL-
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Encyc Occupat Health and Safety
1971)
Skin: Yes (*Sax 1975)
Ingestion: Yes (*Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic;
probable oral lethal dose in humans is 5-50 mg/kg, between 7 drops and 1
teaspoonful for a 150 Ib. person (*Gosselin 1976). It is highly toxic
when inhaled (*Encyc Occupat Health and Safety 1971). Material is a
cholinesterase inhibitor (*Hayes, 1975). It is similar in action to other
organophosphorous pesticides in its toxicity. It is slightly less toxic
than parathion (*Gosselin 1976). Gastrointestinal, neurologic and
respiratory symptoms may accompany poisoning with this material. High
doses may cause a toxic psychosis similar to acute alcoholism (*Rumack
1975 to Present).
Signs and Symptoms of Exposure: Clinical signs and symptoms of
poisoning by this material are similar to that of poisoning by other
organophosphorous pesticides, but damage to the central nervous system is
appreciably less (*Encyc Occupat Health and Safety 1971). Poisoning
victims may display the following symptoms: reduction in cholinesterase
levels ("Hayes 1975); neurologic signs: headache, dizziness, chest pain,
muscle twitching and spasms, profound weakness, psychotic behavior,
incoordination, unconsciousness; gastrointestinal signs: nausea,
vomiting, diarrhea, abdominal pain, increased salivation, incontinence of
feces; and cardiovascular signs: chest pain, slow heart beat, dyspnea
(difficulty in breathing) (-Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Persons taking
phenobarbital and phenaglycodol together, glutethimide, chlorpromazine
hydrochloride, or meprobamate may be at greater risk. These drugs appear
to enhance the toxicity of the material markedly (*Kato 1967).
Emergency and First Aid Procedures: (Non-Specific -- Organophosphorous
Liquid Pesticides) Move patient to fresh air. Monitor for respiratory
distress. Establish respiration using artificial respiration if
necessary. If patient is dermally exposed remove contaminated clothing
and wash skin and hair 3 times (initially soap, then alcohol and soap
again). If the eyes are exposed, flush with copious amounts of water for
at least 15 minutes (*Rumack 1975 to Present).
-------
CAS Registry Number: 152-16-9
Page 4 of 4
DIPHOSPHORAMIDE, OCTAMETHYL-
SECTION VI -- USE INFORMATION
Material is used as a systemic insecticide for plants and as an acaricide
("Merck 1976). Not registered as a pesticide in the U.S. (USEPA/Pesticide
Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Organophosphorus Liquid Pesticides) Use water spray to
knock down vapors. Attempt to stop leak if it can be done without
hazard. Avoid breathing vapors. Keep upwind. Wear self-contained
breathing apparatus. Avoid bodily contact with material. Wear full
protective clothing. Do not handle broken packages without protective
equipment. Wash away any material which may have contacted the body with
copious amounts'of water or soap and water (^Student 1981).
-------
CAS Registry Number: 287-92-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- CYCLOPENTANE
CAS Registry Number: 287-92-3
Synonyms: Pentamethylene
Chemical Formula: C5H10
Molecular Weight: 70.13
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 600 ppm (1,720 mg/m3); STEL 900 ppm (2,580 mg/m3)
(ACGIH 1983, p. 16)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC, inhalation
low
(mouse) 0.00011 mg/liter (*NIOSH/RTECS 1985); LC, inhalation (mouse)
110,000 mg/m3 (NIOSH/RTECS 1983, Volume 1, p. 1018). (SUSPECT)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 120.7°F, 49.26°C (*Weast 1979)
Specific Gravity (H 0=1): 0.7457 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): 400 at 31°C (*Sax 1979)
Melting Point: -137°F, -93.9°C (*Weast 1979)
Vapor Density (AIR=1): 2.42 (»Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Merck 1976)
Appearance and Odor: Colorless liquid (*Hawley 1977) with a mild,
sweet odor like gasoline (Weiss 1980, p. 5)
-------
CAS Registry Number: 287-92-3
Page 2 of 3
CYCLOPENTANE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): -35°F (*Hawley 1977)
Flammable Limits:
LEL: 1.5% (NFPA 1984, p. 325M-30)
UEL: 8.7% (Weiss 1980, p. 295)
Extinguishing Methods: This chemical is flammable and a dangerous fire
risk (*Hawley 1977). Use dry chemical, foam or carbon dioxide. Water may
be ineffective because of low flash point, but should be used to keep
fire-exposed containers cool (NFPA 1984, p. 49-95). Apply water from as
far a distance as possible. Do not extinguish fire unless flow of
chemical can be stopped (Student 1981, p. 162).
Special Fire Fighting Procedures: Water may be ineffective because of
low flash point (*NFPA 1978). Isolate for one-half mile in all directions
if tank car or truck is involved in fire (DOT 1984, Guide 27).
Unusual Fire and Explosion Hazards: Flammable and a dangerous fire
risk (*Hawley 1977). Flashback along vapor trail may occur (Weiss 1980,
p. 295).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 295)
Conditions to Avoid: Heat (*NFPA 1978)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Weiss 1980, p. 295)
Skin: Not Found
Ingestion: Yes (Weiss 1980, p. 295)
-------
CAS Registry Number: 287-92-3
Page 3 of 3
CYCLOPENTANE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): This compound is
moderately toxic by ingestion and inhalation (*Hawley 1977). Ingestion
causes irritation of the stomach, and aspiration produces severe lung
irritation and rapidly developing pulmonary edema. Contact with liquid
irritates eyes and skin. Cyclopentane is a nervous system depressant
(Weiss 1980, p. 295).
Signs and Symptoms of Exposure: Vapors are irritating to eyes, nose
and throat. If inhaled, will cause dizziness, nausea, vomiting, difficult
breathing or loss of consciousness. Ingestion irritates the stomach.
Contact with the liquid is irritating to eyes and skin (Weiss 1980, p.
295).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush eyes with running water for at least 15 minutes. Wash
skin with soap and water. Remove and isolate contaminated clothing and
shoes at site (DOT 1984, Guide 27). Do not induce vomiting, guard against
aspiration (Weiss 1980, p. 295).
SECTION VI -- USE INFORMATION
Used as a solvent; starting material for synthesis in the chemical
industry; solvent for cellulose ethers, motor fuel and azeotropic
distillation agent; and a chemical intermediate in production of
cyclopentadiene (*SRI; *Hawley 1977; *Patty 1963).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep out of low areas. Wear self-contained (positive pressure if
available) breathing apparatus and full protective clothing. Shut off
ignition sources; no flares, smoking or flames in hazard area. Stop leak
if you can do so without risk. Use water spray to reduce vapors. Small
spills: absorb with sand or other noncombustible absorbent material and
place into containers for later disposal. Large spills: dike far ahead
of spill for later disposal (DOT 1984, Guide 27).
-------
CAS Registry Number: 297-78-9
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- ISOBENZAN
CAS Registry Number: 297-78-9
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 697)
4,7-Methanoisobenzofuran, 1,3,4,5,6,7,8,8-Octachloro-1,3,3a,4,7,7a-Hexahydro-;
CP 14,957; ENT 25,545; ENT 25,545-X; 1,3,4,5,6,7,8,8-Octachloro-l,3,3a,4,7,7a-
hexahydro-4,7-methanoisobenzofuran; l,3,4,5,6,7,8,8-Octachloro-2-oxa-3a,4,7,7a-
tetrahydro-4,7-methanoindene; 1,3,4,5,6,7,10,10-Octachloro-4,7-endo-methylene-
4,7,8,9-tetrahydrophthalan; Omtan; SD 4402; Shell 4402; Shell WL 1650;
Telodrin; WL 1650
Chemical Formula: C H.C1 0
Molecular Weight: 411.73
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD _ oral (dog) 1
rag/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): 1.87 (Hayes 1982, p. 251)
Vapor Pressure (mmHg): 1 x 10"5 at 77°F, 25°C (Hayes 1982, p. 251)
Melting Point: 248-252°F, 120-122°C (Merck 1983, pp. 738-739)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 297-78-9
Page 2 of 3
ISOBENZAN
Solubility in Water: Insoluble (Hayes 1982, p. 251)
Appearance and Odor: Crystals (Merck 1983, pp. 738-739). The.
technical product is a whitish to light-brown crystalline powder with a
mild chemical odor (Hayes 1982, p. 251)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Non-flammable and non-explosive (Hayes 1982, p. 251)
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Dry Insecticide) Use agent
suitable for type of surrounding fire. Use water in flooding quantities
as fog. Use alcohol foam, carbon dioxide, or dry chemical (Student 1981,
p. 290).
Special Fire Fighting Procedures: (Non-Specific -- Dry Insecticide)
Avoid breathing dusts and fumes from burning material. Keep upwind.
Avoid bodily contact with the material. Wear full protective clothing
including boots, protective gloves, goggles, and wear self-contained
breathing apparatus (Student 1981, p.290).
Unusual Fire and Explosion Hazards: Chlorine is evolved when this
material is heated above 410°F, 210°C (Hayes 1982, 251).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Acids, certain metal salts, and
catalytically active carriers (Hayes 1982, p. 251)
Hazardous Decomposition or Byproducts: Chlorine is evolved if material
is heated above 410°F, 210°C (Hayes 1982, p. 251).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 297-78-9
Page 3 of 3
ISOBENZAN
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Hayes 1982, p. 251)
Skin: Yes (Hayes 1982, p. 251)
Ingestion: Yes (Hayes 1982, p. 251)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic. It is absorbed by the skin as well as by the respiratory and
gastrointestinal tract. Symptoms may last for a long time because the
material is eliminated slowly; its half-life in human blood is 2.77 years
(Hayes 1982, p. 251).
Signs and Symptoms of Exposure: Symptoms of exposure include headache,
dizziness, drowsiness, irritability, and numbness of the legs.
Convulsions may occur (Hayes 1982, p. 251).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-specific -- Insecticide, Dry,
n.o.s.) Move victim to fresh air; call emergency medical care. Remove
and isolate contaminated clothing and shoes at the site. In case of
contact with material, immediately flush skin or eyes with running water
for at least 15 minutes (DOT 1984, Guide 53).
SECTION VI -- USE INFORMATION
This material is used as an insecticide (Merck 1983, pp. 738-739). Not
registered as a pesticide in the U.S. (USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Dry Insecticide) Keep upwind. Avoid bodily contact with
the material. Wear boots, protective gloves, and goggles (Student 1981,
p. 290). (Non-Specific -- Insecticide, Dry, n.o.s.) Keep unnecessary
people away; isolate hazard area and deny entry. Wear self-contained
(positive pressure if available) breathing apparatus. Small spills:
absorb with sand or other noncombustible absorbent material and place into
containers for later disposal. Small dry spills: with clean shovel place
material into clean, dry container and cover; move containers from spill
area. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 53).
-------
CAS Registry Number: 297-97-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- THIONAZIN
CAS Registry Number: 297-97-2
Synonyms: Phosphorothioic Acid, 0,0-Diethyl 0-Pyrazinyl Ester; AC 18133;
ACC 18133; American Cyanamid 18133; CL 18133; Cynem; 0,0-Diethyl 0-2-Pyrazinyl
Phosphorothioate; Diethyl 0-2-Pyrazinyl Phosphorothionate; 0,0-Diethyl
0-2-Pyrazinyl Phosphothionate; 0,0-Diethyl 0-Pyrazinyl Thiophosphate; EN
18133; ENT 26,680; Ethyl Pyrazinyl Phosphorothioate; Experimental Nematocide
18,133; Nemafos; Nemaphos; Nematocide; Phosphorothioic Acid, 0,0-Diethyl
0-2-Pyrazinyl Ester; Pyrazinol, 0-Ester with 0,0-Diethyl Phosphorothioate;
Zinophos
Chemical Formula: C0H.0N00,PS
O 1.3 / J
Molecular Weight: 248.26
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (rat) 3.5
mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 176°F, 80°C at 0.001 mmHg (Hawley 1981, p. 1019)
Specific Gravity (HJD=1): Not Found
Vapor Pressure (mmHg): 3 x 10"3 at 30°C (Merck 1983, p. 1338)
Melting Point: 29°F, -1.7°C (Hawley 1981, p. 1019)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 297-97-2
Page 2 of 4
THIONAZIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Slightly soluble (Hawley 1981, p. 1019), 1140 ppm
at 24.8°C (*Spencer 1982)
Appearance and Odor: Amber liquid (Hawley 1981, p. 1019); pure
compound is almost colorless liquid and technical product is light brown
to tan mobile liquid ("Spencer 1982)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Organic Phosphate Compound,
Liquid, Poison B). Extinguish with dry chemical, carbon dioxide, water
spray, or foam. Fight fire from maximum distance. Dike fire control
water for later disposal; do not scatter the material (DOT 1984, Guide
55). (Non-Specific -- Parathion) Extinguish fire using agent suitable
for type of surrounding fire. Use water in flooding quantities as fog.
Use foam, carbon dioxide, or dry chemicals (Student 1981, p. 392).
Special Fire Fighting Procedures: (Non-specific -- Organic Phosphate
Compound, Liquid, Poison B). Keep unnecessary people away; stay upwind;
wear positive pressure breathing apparatus and special protective
clothing; remove and isolate contaminated clothing (DOT 1984, Guide 55).
(Non-Specific -- Organic Phosphate Mixture, Liquid, Poison B). Do not
extinguish fire unless flow can be stopped (Student 1981, p. 392).
(Non-Specific -- Parathion) Avoid breathing dusts, and fumes from burning
materials. Avoid body contact with materials. Wear full protective
clothing (Student 1981, p. 392).
Unusual Fire and Explosion Hazards: (Non-Specific -- Organic Phosphate
Compound, Liquid, Poison B). This material may burn but does not ignite
readily (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
-------
CAS Registry Number: 297-97-2
Page 3 of 4
THIONAZIN
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: (Non-Specific -- Organic
Phosphate Compound, Liquid, Poison B). Fire may produce irritating or
poisonous gases (DOT 1984, Guide 55).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Hawley 1981, p. 1019)
Skin: Yes (Hawley 1981, p. 1019)
Ingestion: Yes (Hawley 1981, p. 1019)
Health Hazards (Acute, Delayed, and Chronic): Cholinesterase inhibitor
(Hawley 1981, p. 1019). (Non-Specific -- Organic Phosphate Compound,
Liquid, Poison B). Poisonous; may be fatal if inhaled, swallowed or
absorbed through skin. Contact may cause burns to skin and eyes (DOT
1984, Guide 55).
Signs and Symptoms of Exposure: (Non-Specific -- Parathion). Acute
effects include loss of appetite, nausea, vomiting, diarrhea, excessive
salivation, pupillary constriction, bronchoconstriction, muscle twitching,
convulsions, and coma (Merck 1983, p. 1010).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Organic Phosphate
Compound, Liquid, Poison B). Move victim to fresh air; call emergency
medical care. If not breathing give artificial respiration; if breathing
is difficult give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes; speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site (DOT 1984, Guide 55).
(Non-Specific -- Organic Phosphate Mixture, Liquid, Poison B). Wash away
any material which may have contacted the body with copious amounts of
water or soap and water (Student 1981, p. 381).
SECTION VI -- USE INFORMATION
It is used in insecticides, fungicides, and nematocides (Hawley 1981, p.
1019). Not registered as a pesticide in the U.S. (USEPA/Pesticide Index
1985).
-------
CAS Registry Number: 297-97-2
Page 4 of 4
THIONAZIN
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Organic Phosphate Compound, Liquid, Poison B). Do not
touch spilled material; stop leak if possible; use water spray to reduce
vapors. Small spill: take up with sand or other noncombustible absorbent
material and place into container for later disposal. Large spills: dike
far ahead of spill for later disposal (DOT 1984, Guide 55). (Non-Specific
-- Parathion) Avoid breathing vapors. Avoid bodily contact with
materials. Do not handle broken packages without protective equipment.
Wash away any material which may have contacted the body with copious
amounts of water or soap and water (Student 1981, p. 392).
COMMENTS:
Sources searched and no information found:
Hayes 1982
Weast 1979
Sax 1984
Clayton and Clayton 1981-82
NFPA 1984
NIOSH/OSHA 1978
-------
CAS Registry Number: 298-00-0
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PARATHION-METHYL
CAS Registry Number: 298-00-0
Synonyms: Phosphorothioic Acid, 0,0-Dimethyl 0-(p-Nitrophenyl) Ester (Dry
Mixture); Methyl Parathion; Azofos;. Azophos; BAY 11405; Bladan-M; Dalf;
Dimethylfenitrothion; Dimethyl 4-Nitrophenyl Phosphorothionate; Dimethyl
p-Nitrophenyl Phosphorothionate; Dimethyl p-Nitrophenyl Thiophosphate;
Dimethyl Parathion; E 601; ENT 17,292; Folidol M; Folidol M-40; Gearphos;
M-Parathion; Meptox; Metacid 50; Metacide; Metafos; Metafos (Pesticide);
Metaphos; Methyl-E 605; Methylthiophos; Metron; Metron (Pesticide);
NCI-C02971; Nitrox; Nitrox 80; 0,0-Dimethyl 0-(p-Nitrophenyl)
Phosphorothioate; 0,0-Dimethyl 0-(p-Nitrophenyl) Thionophosphate; 0,0-Dimethyl
0-(p-Nitrophenyl) Thiophosphate; Oleovofotox; Parathion Methyl Homolog;
Partron M; Penncap M; Penncap MLS; Phenol, p-Nitro-, 0-Ester with 0,0-Dimethyl
Phosphorothioate; Phosphorothioic Acid, 0,0-Dimethyl 0-(4-Nitrophenyl) Ester;
Quinophos; Sinafid M-48; Thiophenit; Vofatox; Wofatox; Wofotox; 8056 HC
Chemical Formula: C0H,.NOrPS
o 1U j
Molecular Weight: 263.23
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 0.2 mg/m3 (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.2 mg/m3; STEL 0.6 mg/m3 (skin) (*ACGIH 1983)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat) 0.034 mg/liter/4 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 1.358 at 20°C (*Merck 1983)
Vapor Pressure (mmHg): 9.7 x 10"6 at 20°C ('^Worthing 1979)
-------
CAS Registry Number: 298-00-0
Page 2 of 4
PARATHION-METHYL
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Melting Point: 99-100°F, 37-38°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 50 mg/liter (''-Merck 1983)
Appearance and Odor: White crystalline solid or powder (*NFPA 1978);
odor like rotten eggs or garlic (*CHRIS 1978). Commercial product is a
liquid consisting of 80 percent methyl parathion and 20 percent xylene
(NFPA 1984, pp. 49-64); light to dark tan ("Worthing 1979).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not flammable at normal temperatures
(*Clayton and Clayton 1982); commercial product, containing xylene, has
flashpoint of 115°F (OC) (NFPA 1984, pp. 49-64).
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: For small fires, use dry chemical, carbon
dioxide, water spray, or foam. For large fires, use water spray, fog, or
foam (*DOT 1984).
Special Fire Fighting Procedures: Fight fire from maximum distance.
Dike fire control water for later disposal; do not scatter the material
(*DOT 1984). Wear special protective clothing (-NFPA 1978).
Unusual Fire and Explosion Hazards: Poisonous gases are produced in
fire and when heated (*CHRIS 1978). Decomposition may lead to sufficient
internal pressure to cause the container to rupture violently (NFPA 1984,
pp. 49-64).
t
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: High temperatures (120°F) cause decomposition
(NFPA 1984, pp. 49-64).
-------
CAS Registry Number: 298-00-0
Page 3 of 4
PARATH ION-METHYL
SECTION IV -- REACTIVITY DATA (Continued)
Incompatibility (Materials to Avoid): Oxidizing materials (NFPA 1984,
pp. 49-64).
Hazardous Decomposition or Byproducts: Decomposition may lead to
rupture of containers (NFPA 1984, pp. 49-64).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-DOT 1984)
Skin: Yes (-DOT 1984)
Ingestion: Yes (*DOT 1984)
Health Hazards (Acute, Delayed, and Chronic): This material is
extremely toxic; the probable oral lethal dose is 5-50 mg/kg, or between 7
drops and 1 teaspoonful for a 150-lb. person ("Gosselin 1984). Chronic
toxicity does not appear to be a major consideration (*NRC 1977).
Signs and Symptoms of Exposure: Symptoms may include nausea, vomiting,
abdominal cramps, diarrhea, excessive salivation, headache, giddiness,
dizziness, weakness, muscle twitching, difficult breathing, blurring or
dimness of vision, and loss of muscle coordination. Death may occur from
failure of the respiratory center, paralysis of the respiratory muscles,
intense bronchoconstriction, or all three ("Gosselin 1984).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (*DOT 1984).
-------
CAS Registry Number: 298-00-0
Page 4 of 4
PARATHION-METHYL
SECTION VI -- USE INFORMATION
This material is used as an insecticide on over 50 crops, primarily
cotton, and on several ornamentals (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material; stop leak if you can do it without risk.
Use water spray to reduce vapors. Small spills: take up with sand or
other non-combustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry containers and cover; move containers.from spill area. Large
spills: dike far ahead of spill for later disposal. Wear positive
pressure breathing apparatus and special protective clothing (*DOT 1984).
-------
CAS Registry Number: 298-02-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PHORATE
CAS Registry Number: 298-02-2
Synonyms: Phosphorodithioic Acid, 0,0-Diethyl S-(Ethylthio)Methyl Ester;
Methanethiol, (Ethylthio)-, S-Ester with 0,0-Diethylphosphorodithioate;
0,0-Diethyl S-Ethylmercaptomethyl Dithiophosphonate; 0,0-Diethyl
S-Ethylthiomethyl Dithiophosphonate; 0,0-Diethyl S-(Ethylthio)methyl
Dithiophosphonate; Experimental Insecticide 3911; L 11/6; Thimet; American
Cyanamid 3,911; AC 3911; American Cyanamid 3911; El 3911; ENT 24,042, ENT
24042; Granutox; 0,0-Diethyl Ethylthiomethyl Phosphorodithioate; 0,0-Diethyl
S-Ethylmercaptomethyl Dithiophosphate; 0,0-Diethyl S-Ethylthiomethyl
Thiothionophosphate; Phorate 10G; Rampart; Thimet 10G; Timet; Vegfru; Vergfru
Foratox; VUAgT 182
Chemical Formula: C_H_0 PS-
Molecular Weight: 260.39
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.05 mg/m3 (skin); STEL 0.2 mg/m3 (skin) (*ACGIH
1983)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC inhalation
(rat) 0.011 mg/liter for 1 hour (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 257-261°F, 125-127°C at 2 mmHg (*Merck 1983)
Specific Gravity (H20=l): 1.156 at 25°C (*Merck 1983)
Vapor Pressure (mmHg): 8.4 x 10"4 at 20°C (*Merck 1983)
Melting Point: -45°F, -42.9°C (*Spencer 1982)
-------
CAS Registry Number: 298-02-2
Page 2 of 4
PHORATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 50 rag/liter ("Merck 1983)
Appearance and Odor: Clear liquid (*Merck 1983); objectionable odor
(*0sol 1980)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphorous Pesticide)
Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam
(DOT 1984, Guide 55)
Special Fire Fighting Procedures: (Non-Specific -- Organophosphorous
Pesticide) Wear positive pressure self-contained breathing apparatus.
Move container from fire area if you can do it without risk. Fight fire
from maximum distance. Dike fire control water for later disposal; do not
scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Shock can shatter containers,
releasing the contents. When heated to decomposition, toxic fumes of
sulfur oxides, phosphorus oxides, and nitrogen oxides are emitted (Sax
1984, p. 2208).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Merck 1983)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Hydrolyzed in water and alkalies
(*Merck 1983).
Hazardous Decomposition or Byproducts: When heated to decomposition,
sulfur oxides, phosphorus oxides, and nitrogen oxides are emitted (Sax
1984, p. 2208)
-------
CAS Registry Number: 298-02-2
Page 3 of 4
PHORATE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*ACGIH 1980)
Skin: Yes (*ACGIH 1980)
Ingestion: Yes (*ACGIH 1980)
Health Hazards (Acute, Delayed, and Chronic): This material is one of
the more toxic organophosphorus insecticides (*0sol 1980). It is a
cholinesterase inhibitor that acts on the nervous system, and produces
toxicity similar to Parathion. The probable oral lethal dose for humans
is less than 5 tug/kg, i.e. a taste (less than 7 drops) for a 70 kg (150
Ib.) person (*Gosselin 1976).
Signs and Symptoms of Exposure: Exposure results in tension; anxiety;
restlessness; insomnia; headache; emotional instability; excessive
dreaming and nightmares; apathy and confusion ("Doull 1980); nausea;
vomiting; diarrhea; pinpoint pupils and sensation of tightness in the
chest ("Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Establish clear airway. Wash
thoroughly in case of skin contamination ('"Morgan 1982). (Non-Specific --
Organophosphorous Pesticide) Move victim to fresh air; call emergency.
medical care. If not breathing, give artificial respiration; if breathing
is difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes; speed in
removing material fr^om skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
This material is used as an insecticide and acaricide; it is applied to
plants and soil («SRI).
-------
CAS Registry Number: 298-02-2
Page 4 of 4
PHORATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Organophosphorus Pesticide) Keep unnecessary people
away; isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Ventilate closed spaces before entering them. Wear positive
pressure breathing apparatus and special protective clothing. Remove and
isolate contaminated clothing at the site. Do not touch spilled material;
stop leak if you can do it without risk. Use water spray to reduce
vapors. Small spills: take up with sand or other noncombustible
absorbent material and place into containers for later disposal. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 298-04-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- DISULFOTON
CAS Registry Number: 298-04-4
Synonyms: Phosphorodithioic Acid, 0,0-Diethyl S-(2-(Ethylthio)Ethyl) Ester;
Bay 19639; Bayer 19639; Di-syston; Di-syston G; Dimaz; Disulfaton; Disystox;
Dithiodemeton; Dithiosystox; Dution; Ekatin TD; ENT 23,437; ENT-23437; Ethyl
Thiometon; Ethylthiometon B; Frumin; Frumin AL; Frumin G; Glebofos; M 74
(Pesticide); M-74; 0,0-Diethyl 2-Ethylthioethyl Phosphorodithioate;
0,0-Diethyl S-(2-(Ethylthio)Ethyl) Phosphorodithioate; 0,0-Diethyl
S-(2-Eththioethyl) Phosphorodithioate; 0,0-Diethyl
S-(2-Eththioethyl)Thiothionophosphate; 0,0-Diethyl S-(2-Ethylmercaptoethyl)
Dithiophosphate; 0,0-Diethyl S-2-(Ethylthio)Ethyl Phosphorodithioate;
0,0-Ethyl S-2(Ethylthio)Ethyl Phosphorodithioate; Phosphorodithioic Acid,
0,0-Diethyl S-(2-(Ethylthio)Ethyl) Ester; Phosphorodithionic Acid,
S-2-(Ethylthio)Ethyl 0,0-Diethyl Ester; S 276; S-2-(Ethylthio)Ethyl
0,0-Diethyl Ester of Phosphorodithioic Acid; Solvirex; Thiodemeton;
Thiodemetron; Vuagt 1-4; Vuagt 1964
Chemical Formula: C0H1000PS0
o ly 2 j
Molecular Weight: 274.38
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.1 mg/m3; STEL 0.3 mg/m3 (skin) (*ACGIH 1980)
IDLH: Not Found
Other Limits Recommended: An airborne limit of 0.1 mg/m3 should
serve to limit general room contamination (*ACGIH 1980). Toxicity
information: LD5Q oral (rat) 2 mg/kg (*NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 270-271°F, 132-133°C at 1.5 mmHg (*Merck 1976)
Specific Gravity (H 0=1): 1.144 (*Merck 1976)
Vapor Pressure (mmHg): 1.8 x 10"4 at 20°C (*Spencer 1973)
-------
CAS Registry Number: 298-04-4
Page 2 of 4
DISULFOTON
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Melting Point: Greater than -13°F, -25°C (*Sunshine 1969)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 25 mg/liter at 23°C (*NRC 1977)
Appearance and Odor: Oily, colorless liquid when pure; technical
product is dark yellowish oil (*Spencer 1973). It has a characteristic
sulfur odor (*Sax 1975).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Extinguish with dry chemical, carbon dioxide,
water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Fight fire from maximum distance.
Dike fire control water for later disposal; do not scatter the material.
Wear positive pressure breathing apparatus and special protective clothing
(DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Material may burn but does not
ignite easily. Cylinder may explode in the heat of fire. Poisonous gases
may be generated from the fire or runoff water (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Oxidizable in air (*Sunshine 1969).
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated poisonous gases may
be given off (DOT 1984, Guide 55).
-------
CAS Registry Number: 298-04-4
Page 3 of 4
DISULFOTON
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-DOT 1984)
Skin: Yes (*DOT 1984)
Ingestion: Yes (*DOT 1984)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or
a taste (less than 7 drops) for a 70 kg (150 Ib.) person (*Gosselin
1976). It is poisonous and may be fatal if inhaled, swallowed, or
absorbed through the skin. Contact may cause burns to skin and eyes ("DOT
1984).
Signs and Symptoms of Exposure: Similar to parathion. Exposure can
cause nausea, vomiting, abdominal cramps, diarrhea, excessive salivation,
headache, giddiness, vertigo, and weakness. Death occurs primarily due to
respiratory failure (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Major uses include insecticide for mites and aphids on small grains, corn,
sorghum, cotton, and other field crops, fruits, nuts, and ornamentals
(*SRI).
-------
CAS Registry Number: 298-04-4
Page 4 of 4
DISULFOTON
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spill material. Exposure by skin contact is likely to be
more significant than inhalation (*ACGIH 1980). Small spills: take up
with sand or other noncombustible absorbent materials and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 300-62-9
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- AMPHETAMINE
CAS Registry Number: 300-62-9
Synonyms: Phenethylamine, alpha-Methyl; (+-)-alpha-Methylbenzene-
ethanamine; (+-)-alpha-Methyl Phenethylamine; (+-)-alpha-Methylphenyl
ethylamine; (+-)-beta-Pheny1isopropylamine; (+-)-Desoxynorephedrine;
(Phenylisopropyl)amine; l-Phenyl-2-aminopropane; Acetedron; Adipan; Allodene;
Anorexide; Anorexine; Benzebar; Benzedrine; Benzeneethanamine, alpha-Methyl-,
(+-); Benzolone; beta-Aminopropylbenzene; DL-l-Phenyl-2-Aminopropane;
DL-alpha-Methylphenethylamine; DL-Amphetamine; DL-Benzedrine; Elastonon;
Finam; Isoamyne; Isomyn; Mecodrin; Norephedrane; Norephedrine, deoxy-;
Novydrine; Oktedrin; Ortedrine; Percomon; Phenedrine; Profamina; Propisamine;
Psychedrine; Racemic desoxy-nor-ephedrine; Raphetamine; Rhinalator;
Simpatedrin; Simpatina; Sympamine; Sympatedrine; Weckamine
Chemical Formula: C9H13N
Molecular Weight: 135.20
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD.. oral (rat) 5
mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 392-397°F, 200-203°C (*Merck 1976)
Specific Gravity (H20=l): 0.913 at 25°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): 4.65 (Sax 1984, p. 271)
-------
CAS Registry Number: 300-62-9
Page 2 of 3
AMPHETAMINE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Evaporation Rate (Butyl acetate=l): Evaporates slowly at room
temperature (*Merck 1976).
Solubility in Water: Slightly soluble (-Merck 1976).
Appearance and Odor: Colored liquid; amine odor ("Merck 1976).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 80°F, 26.6°C (no method given) (Hawley
1981, p. 65)
Flammable Limits: It is flammable (Hawley 1981, p. 65)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Extinguish with carbon dioxide or dry chemical
(*Sax 1975).
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Dangerous when exposed to heat or
flames (*Sax 1975).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Can react with oxidizing
materials (*Sax 1975).
Hazardous Decomposition or Byproducts: Upon decomposition, nitrogen
oxides are emitted (*Sax 1975).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 300-62-9
Page 3 of 3
AMPHETAMINE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Not Found
Ingestion: Yes (''-Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
extremely hazardous. Probable lethal dose in humans is 5-50 mg/kg or 7
drops to 1 teaspoon for a 70 kg (150 Ib.) person (-Gosselin 1976). Habit
forming drug which affects the central nervous system (Hawley 1981, p. 65).
Signs and Symptoms of Exposure: Dry mouth, metallic taste, loss of
appetite, nausea, vomiting, diarrhea, abdominal cramps, headache,
chilliness, flushing or pallor, palpitation, restlessness, dizziness,
tremor, hyperactive reflexes, talkativeness, tenseness, irritability,
weakness, insomnia, fever, confusion. With large doses, irregular
heartbeat, pain and difficulty in urination ("Goodman 1975). Convulsions,
coma, circulatory collapse (Gosselin 1976, p. 11-369).
Medical Conditions Generally Aggravated by Exposure: Excessive use may
lead to tolerance and physical dependence ("Merck 1976). Death is
possible (Gosselin 1976, p. 11-369).
Emergency and First Aid Procedures: (Non-Specific -- Drugs, n.o.s.)
Move victim to fresh air; call emergency medical care. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen. In
case of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Remove and isolate contaminated clothing
and shoes at the site. Keep victim quiet and maintain normal body
temperature (DOT 1984, Guide 11).
SECTION VI -- USE INFORMATION
Amphetamine is used as a pharmaceutical (Hawley 1981, p. 65). It is a
central nervous system stimulant (*Rossoff 1974).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
s
(Non-Specific -- Drugs, n.o.s.) Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas. Wear
self-contained (positive pressure if available) breathing apparatus and
full protective clothing. Shut off ignition sources; no flares, smoking .
or flames in hazard area. Keep combustibles (wood, paper, oil, etc.) away
from spilled material. Do not touch spilled material. Small spills:
absorb with sand or other noncombustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 11).
-------
CAS Registry Number: 302-01-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- HYDRAZINE
CAS Registry Number: 302-01-2
Synonyms: Diamine; Hydrazine Anhydrous; Hydrazine Base; Hydrazine,
Anhydrous; Levoxine
Chemical Formula: H.N.
4 2
Molecular Weight: 32.05
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 1 ppm (skin) (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.1 ppm (skin) (*ACGIH 1983)
IDLH: 80 ppm (*Encyc Occupat Health and Safety 1983)
Other Limits Recommended: Short-term inhalation limits - 1 ppm for 30
minutes (Weiss 1980, p. 509); Occupational Exposure to Hydrazines
Recommended Standard Air Ceiling 0.04 mg/m3/2 hours (*NIOSH/RTECS
1985). Industrial Substance Suspect of Carcinogenic Potential for Humans
-- Recommended TLV 0.1 ppm (skin) (ACGIH 1984, p. 42).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 236.3°F, 113.5°C (*Merck 1983)
Specific Gravity (H 0=1): 1.011 at 15°C/4°C (-Merck 1983)
Vapor Pressure (mmHg): 14.4 at 25°C (*Sunshine 1969)
Melting Point: 36°F, 2.0°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (*Merck 1983)
-------
CAS Registry Number: 302-01-2
Page 2 of 4
HYDRAZINE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Colorless, oily liquid with penetrating
ammonia-like odor (*Merck 1983).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 52°C (*Merck 1983)
Flammable Limits:
LEL: 4.7% (*NFPA 1978)
DEL: 100% (*NFPA 1978)
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray or foam. Large fires: water spray, fog, or foam (DOT 1984,
Guide 28).
Special Fire Fighting Procedures: Stay upwind; keep out of low areas.
Wear positive pressure breathing apparatus and protective clothing.
Isolate for one-half mile in all directions if tank car or truck is
involved in fire. Move container from fire area if you can do so without
risk. Dike fire control water for later disposal; do.not scatter
material. Spray cooling water on containers that are exposed to flames
until well after fire is out (DOT 1984, Guide 28).
Unusual Fire and Explosion Hazards: It is a flammable/combustible
material and may be ignited by heat, sparks, or flames. Vapor may travel
to a source of ignition and flash back. Container may explode in heat of
fire. Vapor explosion and poison hazard indoors, outdoors, or in sewers.
Runoff to sewer may create fire or explosion hazard (DOT 1984, Guide 28).
Vapors form explosive mixtures with air (NFPA 1984, pp. 49-52). May
continue to burn in the absence of air (*Bretherick 1979).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*NFPA 1978)
Stable:
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Can catch fire when in contact
with porous materials such as wood, asbestos, cloth, earth, and rusty
metals (Weiss 1980, p. 509). Incompatible with oxidizers, hydrogen
peroxide, nitric acid, metal oxides, and strong acids (NIOSH/OSHA 1978,
p. 110).
-------
CAS Registry Number: 302-01-2
Page 3 of 4
HYDRAZINE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: Decomposition gives off toxic
nitrogen compound fumes (*Rumack 1975 to Present).
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 509)
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (NIOSH/OSHA 1978, p. 110)
Skin: Yes (NIOSH/OSHA 1978, p. 110)
Ingestion: Yes (NIOSH/OSHA 1978, p. 110)
Health Hazards (Acute, Delayed, and Chronic): Target organs affected
include central nervous system; respiratory system; skin and eyes
(NIOSH/OSHA 1978, p. 110). Chronic exposure in humans may cause
pneumonia, liver and kidney damage. Liver damage may be more severe than
kidney damage (Gosselin 1976, p. 11-247). It is a suspected human
carcinogen (ACGIH 1984, p. 42).
Signs and Symptoms of Exposure: Symptoms include irritation of eyes,
nose, and throat; temporary blindness; dizziness; nausea; dermatitis and
burning skin (NIOSH/OSHA 1978, p. 110). Inhalation may cause nausea,
headache, facial numbness, twitching, sore throat, and pulmonary edema.
Acute exposure may cause seizures and coma, and increased blood sugar
levels (*Rumack 1975 to Present). Chemical burns result from skin contact
(*ACGIH 1980).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Remove and isolate contaminated
clothing and shoes at the site. In case of contact with material
immediately flush skin or eyes with running water for at least 15
minutes. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 28).
-------
CAS Registry Number: 302-01-2
Page 4 of 4
HYDRAZINE
SECTION VI -- USE INFORMATION
Chemical intermediate for pesticides, blowing agents, photography
chemicals, Pharmaceuticals, antituberculants, textile dyes ("SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation of vapors (see Section V above). Shut off ignition
sources; no flares, smoking or flames in hazard area. Do not touch
spilled material; stop leak if you can do so without risk. Use water
spray to reduce vapors. Small spills: absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal.
Keep unnecessary people away; isolate hazard area and deny entry. Stay
upwind; keep but of low areas. Wear positive pressure breathing apparatus
and special protective clothing. In case of contact with material,
immediately flush skin or eyes with running water for at least 15 minutes
(DOT 1984, Guide 28).
-------
CAS Registry Number: 309-00-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ALDRIN
CAS Registry Number: 309-00-2
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 113) 1,4:5,8-
Dimethanonaphthalene, 1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-Hexahydro-;
Aldrex; Aldrite; Aldrosol; Aldrin, Cast Solid; Aldrin Mixture, Dry; Aldrin
Mixture, Liquid; Compound 118; Drinox; ENT 15,949; Hexachlorohexahydro-
endo-exo-Dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-
Hexahydro-1,4,5,8-Dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-
Hexahydro-exo-l,4-endo-5,8-Dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-
1,4,4a,5,8,8a-Hexahydro-l,4-endo-exo-5,8-Dimethanonaphthalene; HHDN;
NCI-C00044; Octalene; Seedrin; 1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-
Hexachloro- 1,4,4a,5,8,8a-Hexahydro-, (1 alpha, 4 alpha, 4a beta, 5 alpha, 8
alpha, 8a beta)-
Chemical Formula: C--H..C1-
1Z O D
Molecular Weight: 364.90
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: 0.25 mg/m3 (NIOSH/OSHA 1978, p. 42)
ACGIH TLV: 0.25 mg/m3 (ACGIH 1984, p. 11)
IDLH: 100 mg/m3 (NIOSH/OSHA 1978, p. 42)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 293°F, 145°C at 2 mmHg (Hayes 1982, p. 234); decomposes
(NIOSH/OSHA 1978, p. 42)
Specific Gravity (H20=l): 1.70 at 20°C (Hayes 1982, p. 234)
Vapor Pressure (mmHg): 6 x 10"6 at 25°C (Hayes 1982, p. 234)
Melting Point: (Pure) 219°F, 104°C; (Technical) 120-140°F, 49-60°C
(Hayes 1982, p. 234)
-------
CAS Registry Number: 309-00-2
Page 2 of 4
ALDRIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.027 rag/liter (Hayes 1982, p. 234)
Appearance and Odor: (Pure) Odorless, white solid. (Technical) Tan to
dark brown solid with a mild "chemical" odor (Hayes 1982, p. 234).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Approximately 150°F or higher (no method
given) (NFPA 1984, p. 49-13)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Not Flammable (Hayes 1982, p. 234). Extinguish
by using water spray, dry chemical, foam, or carbon dioxide. Use water to
keep fire-exposed containers cool. Use water spray to disperse the vapors
(NFPA 1984, p. 49-13).
Special Fire Fighting Procedures: Wear full protective clothing (NFPA
1984, p. 49-13) including positive pressure breathing apparatus. Small
fires: dry chemical, carbon dioxide, water spray, or foam. Large fires:
water spray, fog, or foam. Move container from fire area if you can do so
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of chlorine containing compounds (Sax 1984, p. 153).
Commercial solutions may contain flammable or combustible liquids. The
dry powder will not burn (NFPA 1984, p. 49-13). Container may explode in
heat of fire (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Avoid concentrated mineral
acids, acid catalysts, acid oxidizing agents, phenols, or active metals
(Hayes 1982, p. 234).
-------
CAS Registry Number: 309-00-2
Page 3 of 4
ALDRIN
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits toxic fumes of chlorine containing compounds (Sax 1984, p. 153).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (NIOSH 1978, p. 42)
Skin: Yes (NIOSH 1978, p. 42)
Ingestion: Yes (NIOSH 1978, p. 42)
Health Hazards (Acute, Delayed, and Chronic): Poisoning by aldrin
usually involves convulsions due to its effects on the central nervous
system. Reproductive effects and liver effects have also been reported
(Doull 1980, p. 383; Hayes 1982, p. 235). It is classified as an
extremely toxic chemical. Probable oral lethal dose for humans is
between 7 drops and one oz. for a 150 Ib. adult human (Gosselin 1976, p.
186). Conflicting reports of carcinogenicity of this compound remain an
area of controversy (Doull 1980, p. 383). Similar chemically and
toxicologically to dieldrin (Gosselin 1984, p. 11-285).
Signs and Symptoms of Exposure: Aldrin tends to produce convulsions
before other, less serious signs of illness have appeared. Victims have
reported headache, nausea, vomiting, dizziness, and mild clonic jerking.
Some victims have convulsions without warning. Aldrin can burn the skin
and eyes (Oilman 1985, p. 1640; Hayes 1982, p. 234).
Medical Conditions Generally Aggravated by Exposure: Not Found
o
Emergency and First Aid Procedures: Treatment is symptomatic (Hayes,
1982, p. 237). Move victim to fresh air; call emergency medical care. If
not breathing, give artificial respiration. If breathing is difficult,
give oxygen. In case of contact with material, immediately flush skin or
eyes with running water for at least 15 minutes. Speed in removing
material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 309-00-2
Page 4 of 4
ALDRIN
SECTION VI -- USE INFORMATION
Formerly used as an insecticide; manufacture and use have been
discontinued in the USA (Merck 1983, p. 36). Registered as a termicide in
the U.S. (USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation (see Section V). Do not touch spilled material; stop
leak if you can do so without risk. Wear positive pressure breathing
apparatus and special protective clothing. Use water spray to reduce
vapors. Small spills: absorb with sand or other noncombustible absorbent
material and place into containers for later disposal. Small dry spills:
with clean shovel place material into clean, dry container and cover; move
containers from spill area. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 315-18-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- MEXACARBATE
CAS Registry Number: 315-18-4
Synonyms: Carbamic Acid, Methyl-, 4-Dimethylamino-3,5-xylyl Ester;
Zectran; 3,5-Dimethyl-4-(Dimethylamino)Phenyl Methylcarbamate; 3,5-Xylenol,
4-(Dimethylamino)-, Methylcarbamate; 4-(Dimethylamino)-3,5-Xylyl
N-Methylcarbamate; 4-(Dimethylamino)-3,5-Dimethylphenol Methylcarbamate
(Ester); 4-(Dimethylamino)-3,5-Dimethylphenyl N-Methylcarbamate;
4-(Dimethylamino)-3,5-Xylenol, Methylcarbamate (Ester); 4-(N,N-Dimethylamino)•
3,5-Xylyl N-Methylcarbamate; 4-Dimethylamino-3,5-Dimethylphenyl
Methylcarbamate; 4-Dimethylamino-3,5-Dimethylphenyl N-Methylcarbamate;
4-Dimethylamino-3,5-Xylenyl N-Methylcarbamate; 4-Dimethylamino-3,5-Xylyl
Methylcarbamate; 4-Dimethylamino-3,5-Xylyl N-Methylcarbamate; Carbamate,
4-Dimethylamino-3,5-Xylyl, N-Methyl-; Carbamic Acid, Methyl-,
4-(Dimethylamino)-3,5-Dimethylphenyl Ester; Carbamic Acid, Methyl-,
4-(Dimethylamino)-3,5-Xylyl Ester; Dowco 139; Dowco-139; ENT 25,766; ENT
25766; ENT-25,766; MAZ; Methyl-4- Dimethylamino-3,5-Xylyl Carbamate;
Methyl-4-Dimethylamino-3,5-Xylyl Ester of Carbamic Acid; Methylcarbamic Acid
4-(Dimethylamino)-3,5-Xylyl Ester; Methylcarbamic Acid,
4-(Dimethylamino)-3,5-Xylyl Ester; Mexicarbate; NCI-C00544; OMS-47; Phenol,
4-(Dimethylamino)-3,5-Dimethyl-, Methylcarbamate (Ester); Zactran; Zectane;
Zextran; Phenol, 4-(Dimethylamino)- 3,5-Dimethyl-, Methylcarbamate (Ester)
Chemical Formula: C,0H10N00.
lz lo A. L
Molecular Weight: 222.29
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD oral (rat) 14
mg/kg (*NIOSH/RTECS 1985)
-------
CAS Registry Number: 315-18-4
Page 2 of 4
MEXACARBATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Less than 0.1 at 139°C ('''Merck 1983)
Melting Point: 185°F, 85°C (*Merck 1983)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.01% at 25°C (*Merck 1983)
Appearance and Odor: White crystalline solid, odorless (*Martin 1974)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Carbamate Pesticide, Solid,
n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or
foam. Large fires: water spray, fog, or foam. Dike fire control water
for later disposal; do not scatter the material (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: (Non-Specific -- Carbamate
Pesticide, Solid, n.o.s.) Fire may produce irritating or poisonous
gases. This material may burn but does not ignite readily. Container may
explode in heat of fire (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Martin 1974)
Conditions to Avoid: Subject to photo-decomposition in the solid
state (*IARC 1972-1985).
-------
CAS Registry Number: 315-18-4
Page 3 of 4
MEXACARBATE
SECTION IV -- REACTIVITY DATA (Continued)
Incompatibility (Materials to Avoid): Decomposition in highly alkaline
media (*Martin 1974).
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits toxic fumes of nitrogen oxides (Sax 1984, p. 1108).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Non-Specific -- Carbamate Pesticide,
Solid, n.o.s) (DOT 1984, Guide 55)
Skin: Yes (Non-Specific -- Carbamate Pesticide,
Solid, n.o.s.) (DOT 1984, Guide 55)
Ingestion: Yes (-Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic:
probable oral lethal dose for humans is 5-50 mg/kg; between 7 drops and 1
teaspoonful for 70 kg person (150 Ib.) (*Gosselin 1976). (Non-Specific --
Carbamate Pesticide, Solid, n.o.s.) Poisonous; may be fatal if inhaled,
swallowed, or absorbed through skin. Contact may cause burns to skin and
eyes (DOT 1984, Guide 55).
Signs and Symptoms of Exposure: Symptoms of carbamate poisoning
resemble those of parathion. This material is similar to carbaryl;
symptoms of carbaryl exposure include nausea, vomiting, abdominal cramps,
diarrhea, excessive salivation, sweating, lassitude and weakness. Runny
nose and sensation of tightness in chest may occur with inhalation
exposures. Blurring or dimness of vision, tearing, eye muscle spasm, loss
of muscle coordination, slurring of speech, and twitching of muscles may
also occur (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
-------
CAS Registry Number: 315-18-4
Page 4 of 4
MEXACARBATE
SECTION V -- HEALTH HAZARD DATA (Continued)
Emergency and First Aid Procedures: (Non-Specific -- Carbamate
Pesticide, Solid, n.o.s.) Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
It is an insecticide for non-agricultural uses, e.g., lawn and turf,
flowers, gardens, vines, forest lands, woody shrubs and trees and also a
molluscicide. It is not produced commercially in the United States (*SRI)
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Carbamate Pesticide) Keep sparks, flames, and other
sources of ignition away. Keep material out of water sources and sewer.
Avoid bodily contact with the material. If contact with material is
anticipated, wear full protective clothing including boots, protective
gloves, and goggles (Student 1981, p. 104).
-------
CAS Registry Number: 316-42-7
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- EMETINE, DIHYDROCHLORIDE
CAS Registry Number: 316-42-7
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 192) Amebicide;
(-)-Emetine Dihydrochloride; 1-Emetine Dihydrochloride; Emetine,
Hydrochloride; NSC-33669
Chemical Formula: C.-H.-N-O, »2HC1
29 40 2 4
Molecular Weight: 553.63
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD, oral (cat,
rabbit) 15 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 455-491°F, 235-255°C decomposes (Merck 1983, p. 514)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Contains water of hydration varying from 3 to 8
molecules of water; 1 g of hydrated salt dissolves in 7 mL (Merck 1983,
p. 514)
-------
CAS Registry Number: 316-42-7
Page 2 of 4
EMETINE, DIHYDROCHLORIDE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Clusters of needles after drying at 221°F, 105°C;
turns yellow on exposure to light or heat ((Merck 1983, p. 514)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Emetine is an alkaloid (Merck 1983, p. 513).
Extinguishing methods for alkaloid salts are as follows. Small fires:
dry chemical, carbon dioxide, water spray, or foam. Large fires: water
spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Procedures for alkaloid salts
include the following. Move container from fire area if you can do so
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material. Keep unnecessary people
away; isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Ventilate closed spaces before entering them. Wear positive
pressure breathing apparatus and special protective clothing (DOT 1984,
Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of chlorides, hydrogen chloride and oxides of
nitrogen (Sax 1984, p. 1275).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Turns yellow on exposure to light or heat
(Merck 1983, p. 514)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of chlorides, hydrogen chloride, and oxides of
nitrogen (Sax 1984, p. 1275).
-------
CAS Registry Number: 316-42-7
Page 3 of 4
EMETINE, DIHYDROCHLORIDE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 1275)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic orally. It is an eye irritant (Sax 1984, p. 1275). (Non-Specific
-- Emetine) Emetine is classified as extremely toxic. Probable oral
lethal dose for humans is 5-50 mg/kg, or between 7 drops and one teaspoon
for a 150-lb person (Gosselin 1984, p. 11-244).
Signs and Symptoms of Exposure: (Non-Specific -- Emetine) Symptoms
include nausea, vomiting, diarrhea, muscle weakness, pain, tenderness,
hypotension, precordial pain and rapid heartbeat (Gosselin 1984, p.
11-244).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Emetine is an alkaloid (Merck
1983, p. 513). Procedures for alkaloid salts are as follows. Move victim
to fresh air; call emergency medical care. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. In case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Speed in removing material from skin is of
extreme importance. Remove and isolate contaminated clothing and shores
at the site. Keep victim quiet and maintain normal body temperature.
Effects may be delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Emetine, dihydrochloride is an injectable form of emetine (Oilman 1984, p.
1051). It is an antiamebic (Merck 1983, p. 514). Emetine is the active
ingredient of ipecac (Gosselin 1984, p. 11-244).
-------
CAS Registry Number: 316-42-7
Page 4 of 4
EMETINE, DIHYDROCHLORIDE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
The following procedures should be used for alkaloid salts. Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Ventilate closed spaces before entering them.
Wear positive pressure breathing apparatus and special protective
clothing. Remove and isolate contaminated clothing at the site. Do not
touch spilled material; stop leak if you can do it without risk. Use
water spray to reduce vapors. Small spills: take up with sand or other
noncombustible absorbent material and place into containers for later
disposal. Small dry spills: with clean shovel place material into clean,
dry container and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal (DOT 1984, Guide 55).
COMMENTS:
Sources searched but no information found:
NFPA 1984
Weiss 1980
ACGIH 1983
NIOSH/OSHA 1978
Encyc Occupat Health and Safety 1983
Weast 1979
Physicians' Desk Reference 1985
Farm Chemicals Handbook 1984
-------
CAS Registry Number: 327-98-0
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- TRICHLORONATE
CAS Registry Number: 327-98-0
Synonyms: 5082A; Agrisil; Agritox; Bay 37289; Bayer 37289; Bayer 5081;
Bayer S 4400; Chemagro 37289; ENT 25,712; ENT-25712; Ethyl
Trichlorophenylethylphosphonothioate; Fenophosphon; Fitosol; 0-Ethyl
0-2,4,5-Trichlorophenyl Ethylphosphonothioate; Phenol, 2,4,5-Trichloro-,
0-Ester with 0-Ethyl Ethylphosphonothioate; Phosphonothioic Acid, Ethyl-,
0-Ethyl 0-(2,4,5-Trichlorophenyl) Ester; Phytosol; Richloronate; S 4400;
Trichloronat
Chemical Formula: C H Cl 0 PS
Molecular Weight: 333.60
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: I^c0 oral (cat) 10
mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 226°F, 108°C at 0.01 mmHg (^Worthing 1979)
Specific Gravity (H 0=1): 1.365 at 20°C/4°C (^Worthing 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 50 mg/liter at 20°C (^Worthing 1979)
Appearance and Odor: Amber colored liquid (*Worthing 1979)
-------
CAS Registry Number: 327-98-0
Page 2 of 4
TRICHLORONATE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphate Pesticide,
Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray,
or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Organophosphate
Pesticide, Liquid, n.o.s.) Move container from fire area if you can do it
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material. Wear positive pressure
breathing apparatus and special protective clothing (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of chlorine containing compounds, phosphorus
oxides, and sulfur oxides (Sax 1984, p. 1397).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits very toxic fumes of chlorine containing compounds, phosphorus
oxides, and sulfur oxides (Sax 1984, p. 1397).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Non-Specific -- Organic Phosphorus
Pesticides) (Hayes 1982, p. 301)
Skin: Yes (Non-Specific -- Organic Phosphorus
Pesticides) (Hayes 1982, p. 301)
Ingestion: Yes (Sax 1984, p. 1397)
-------
CAS Registry Number: 327-98-0
Page 3 of 4
TRICHLORONATE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Material is an
organophosphate (*Rumack 1975 to Present) and toxic effects are due to
action on the nervous system (Hayes 1982, p. 301). It has high oral
toxicity (Sax 1984, p. 1397) and death can occur in acute poisonings
(*DeReuch 1979). Delayed neurotoxicity has been reported (*Rumack 1975 to
Present).
Signs and Symptoms of Exposure: Headache, dizziness, nausea,
salivation, vomiting, abdominal pain, diarrhea, chest pain, decreased
heart rate, excessive discharge of mucous from the air passages, difficult
breathing, contraction of the pupil, blurred vision, profuse perspiration,
muscle twitching and spasms, profound weakness, psychotic behavior,
uncoordination, unconsciousness, rarely convulsions. Low level absorption
syndrome is similar to influenza. High dosage may cause toxic psychosis
similar to alcoholism. Exposures may be misdiagnosed as asthma and heart
failure (*Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Organophosphate
Pesticide, Liquid, n.o.s.) Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Non-systemic insecticide ('"'Worthing 1979). Not marketed in the U.S.A. or
Canada (Farm Chemicals Handbook 1984, p. C-7). Not registered as a
pesticide in the U.S. (USEPA/Pesticide Index 1985).
-------
CAS Registry Number: 327-98-0
Page 4 of 4
TRICHLORONATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation (see Section V above). (Non-Specific -- Organophosphate
Pesticide, Liquid, n.o.s.) Do not touch spilled material; stop leak if
you can do so without risk. Use water spray to reduce vapors. Small
spills: absorb with sand or other noncombustible absorbent material and
place into containers for later disposal. Large spills: dike far ahead
of spill for later disposal. Keep unnecessary people away; isolate hazard
area and deny entry. Stay upwind; keep out of low areas. Ventilate
closed spaces before entering them. Wear positive pressure breathing
apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site (DOT 1984, Guide 55).
-------
CAS Registry Number: 353-42-4
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- BORON TRIFLUORIDE COMPOUND WITH
METHYL ETHER (1:1)
CAS Registry Number: 353-42-4
Synonyms: (NIOSH/RTECS 1983 Synonym, Volume 1, p. 741) Boron,
Trifluoro(0xybis(methane))-,(T-4)-; Boron Trifluoride-Dimethyl Ether; (SANSS
1983 Synonyms): Methyl Ether, compound with Boron Fluoride (1:1); Boron
Fluoride Complex with Dimethyl Ether; Boron Trifluoride Compound with Methyl
Ether; Boron Trifluoride Dimethyl Ether Addition Compound; Boron Trifluoride
Dimethyl Etherate; Boron Trifluoride Dimethyl Ether Complex
Chemical Formula: C0H-0«BF.
/ b j
Molecular Weight: 113.89
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(guinea pig) 0.233 mg/liter/4 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
-------
CAS Registry Number: 353-42-4
Page 2 of 4
BORON TRIFLUORIDE COMPOUND WITH
METHYL ETHER (1:1)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Not Found
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This material may react violently with water.
For small fires, use dry chemical, carbon dioxide, water spray, or foam.
For large fires, use water spray, fog, or foam (DOT 1984, Guide 29).
Special Fire Fighting Procedures: Wear self-contained, positive-
pressure breathing apparatus and full protective clothing. Move
containers from fire area if possible. Do not get water inside
containers. Spray cooling water on containers that are exposed to flame
until well after fire is out. Withdraw immediately in case of rising
sound from venting safety device or any discoloration of tank due to
fire. Isolate for 1/2 mile in all directions if tank car or truck is
involved in fire (DOT 1984, Guide 29).
Unusual Fire and Explosion Hazards: Fire may produce irritating or
poisonous gases. Flammable/combustible material which may be ignited by
heat spark or flame. Vapors may travel to a source of ignition and flash
back. Container may explode in heat of fire. Vapor explosion hazard
indoors, outdoors, or in sewer. Runoff to sewer may create fire or
explosion hazard (DOT 1984, Guide 29).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): This material may react
violently with water (DOT 1984, Guide 29).
-------
CAS Registry Number: 353-42-4
Page 3 of 4
BORON TRIFLUORIDE COMPOUND WITH
METHYL ETHER (1:1)
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of fluorides (Sax 1984, p. 515).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 515)
Skin: Yes (DOT 1984, Guide 29)
Ingestion: Yes (Non-Specific -- Boron Compounds)
(Sax 1984, p. 513)
Health Hazards. (Acute, Delayed, and Chronic): This material is highly
toxic by inhalation (Sax 1984, p. 515).
Signs and Symptoms of Exposure: Contact may cause burns to skin and
eyes (DOT 1984, Guide 29).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. Remove and isolate contaminated clothing at site. In case of
contact with material, immediately flush skin or eyes with running water
for at least 15 minutes. Keep victim quiet and maintain normal body
temperature (DOT 1984, Guide 29).
SECTION VI -- USE INFORMATION
Not Found
-------
CAS Registry Number: 353-42-4
Page 4 of 4
BORON TRIFLUORIDE COMPOUND WITH
METHYL ETHER (1:1)
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away and isolate hazard area. Stay upwind and
keep out of low areas. Wear self-contained, positive-pressure breathing
apparatus and full protective clothing. Shut off ignition sources. Do
not touch spilled material. Use water spray to reduce vapors, but do not
get water inside containers. For small spills, absorb with sand or other
noncombustible absorbent material and place into containers. For large
spills, dike far ahead of spill for later disposal (DOT 1984, Guide 29).
COMMENTS
Sources searched but no information found:
ACGIH 1983
NIOSH/OSHA 1978
Hawley 1981
Weast 1979
Merck 1983
NFPA 1984
Student 1981
Weiss 1980
CHRIS 1978
Doull 1980
Clayton and Clayton 1981-82
Arena 1979
Gosselin 1984
Encyc Occupat Health and Safety 1983
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
Physicians' Desk Reference 1985
Oilman 1985
-------
CAS Registry Number: 359-06-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- FLUOROACETYL CHLORIDE
CAS Registry Number: 359-06-8
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 252): Acetyl Chloride,
Fluoro-; TL 670
Chemical Formula: C H C1FO
Molecular Weight: 96.49
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC, inhalation
(guinea pig) 0.1 mg/liter/10 minutes (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Not Found
-------
CAS Registry Number: 359-06-8
Page 2 of 4
FLUOROACETYL CHLORIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Chloroacetyl Chloride and
Fluoroacetic Acid) Extinguish with dry chemical, carbon dioxide, water
spray, fog, or foam (DOT 1984, Guide 59).
Special Fire Fighting Procedures: (Non-specific -- Chloroacetyl
Chloride and Fluoroacetic Acid) Spray cooling water on containers that
are exposed to flames until well after fire is out. Move container from
fire area if you can do so without risk. Do not get water in container,
as material may react violently with water (DOT 1984, Guide 59).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of chlorine and fluorine-containing compounds (Sax
1984, p. 1430). (Non-Specific -- Chloroacetyl Chloride and Fluoroacetic
Acid) Some of these materials may ignite combustibles (i.e., wood, paper,
oil, etc.) or react violently with water (DOT 1984, Guide 59).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of chlorine and fluorine-containing compounds
(Sax 1984, p. 1430).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 359-06-8
Page 3 of 4
FLUOROACETYL CHLORIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1430)
Skin: Not Found
Ingestion: Yes (Non-Specific -- Chloroacetyl
Chloride) (NFPA 1984, p. 49-29) .
Health Hazards (Acute, Delayed, and Chronic): Highly toxic by
inhalation (Sax 1984, p. 1430). (Non-Specific -- Chloroacetyl Chloride)
Corros°ive to skin and irritating to eyes (NFPA 1984, p. 49-29).
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Chloroacetyl
Chloride and Fluoroacetic Acid) Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Remove and isolate contaminated clothing and shoes at site.
Keep victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 59).
SECTION VI -- USE INFORMATION
Not Found
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Chloroacetyl Chloride and Fluoroacetic Acid) Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Wear self-contained, breathing apparatus (positive
pressure if available) and full protective clothing. Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors (may react violently with water). Small spills: absorb
with sand or other non-combustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 59).
-------
CAS Registry Number: 359-06-8
Page 4 of 4
FLUOROACETYL CHLORIDE
COMMENTS:
Sources searched but no information found:
Weast 1979
Hawley 1981
Hayes 1982
BASE 1980
ACGIH 1983
NIOSH/OSHA 1978
Merck 1983
Oilman 1985
Gosselin 1984
Weiss 1980
Clayton and Clayton 1981-82
Farm Chemicals Handbook 1984
Doull 1980
Buchel 1983
-------
CAS Registry Number: 371-62-0
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ETHYLENE FLUOROHYDRIN
CAS Registry Number: 371-62-0
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 252): Ethanol,
2-Fluoro-; beta-Fluoroethanol; 2-Fluoroethanol; TL 741
Chemical Formula: C H FO
Molecular Weight: 64.07
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LCL inhalation
(rat) 0.14 mg/liter/4 hours (-NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 218.3°F, 103.5°C (Weast 1979, p. C-297)
Specific Gravity (H20=l): 1.1040 at 20°C/4°C (Weast 1979, p. C-297)
Vapor Pressure (mmHg): Not Found
Melting Point: -15.61°F, -26.45°C (Weast 1979, p. C-297)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Miscible (Weast 1979, p. C-297)
Appearance and Odor: Liquid (Hayes 1983, p. 500)
-------
CAS Registry Number: 371-62-0
Page 2 of 3
ETHYLENE FLUOROHYDRIN
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 31°C (Hayes 1982, p. 500)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Toxic fluoride fumes may be
emitted in a fire (Sax 1984, p. 1437).
SECTION IV --REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of fluorides (Sax 1984, p. 1437).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1437)
Skin: Yes (Sax 1984, p. 1437)
Ingestion: Yes (Hayes 1982, p. 500)
Health Hazards (Acute, Delayed, and Chronic): Toxicity rating is the
same as for fluoroacetate, super toxic. The probable'oral lethal dose in
humans is a taste (less than 7 drops) for a 70 kg (150 Ib.) person
(Gosselin 1984, p. 11-198). The chemical is highly toxic when inhaled or
absorbed through the skin (Sax 1984, p. 1437). Toxicity depends on its
oxidation to fluoroacetate by tissue alcohol dehydrogenase (Hayes 1982, p.
500).
-------
CAS Registry Number: 371-62-0
Page 3 of 3
ETHYLENE FLUOROHYDRIN
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Symptoms include tremors, severe
muscular weakness, nausea, headache, and slight swelling of the liver
(Hayes 1982, p. 500). Delayed convulsant (Gosselin 1984, p. 11-198).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Acute poisoning should be treated
like poisoning by fluoroacetate. Ethylene fluorohydrin (2-fluoroethanol)
is listed among the organic fluorine derivatives of fluoroacetic acid
(Hayes 1982, p. 501). The emergency procedures for fluoroacetic acid
are: move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 59).
SECTION VI -- USE INFORMATION
Ethylene Fluorohydrin is used as a rodenticide (Hayes 1982, p. 500)
insectide (Gosselin 1984, p. III-193), and acaricide (Buchel 1983, p. 177).
Not registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact; wear proper respiratory protection and
protective clothing (see Section V above). (Non-Specific -- Fluoroacetic
Acid) Do not touch spilled material; stop leak if you can do so without
risk. Use water spray to reduce vapors. Small spills: absorb with sand
or other noncombustible absorbent material and place into containers for
later disposal. Large spills: dike far ahead of spill for later disposal
(DOT 1984, Guide 59).
COMMENTS:
Sources searched but no information found:
Student 1981
DASE 1980
Hawley 1981
NFPA 1984
Weiss 1980
Merck 1983
CHRIS 1978
Farm Chemicals Handbook 1984
-------
CAS Registry Number: 379-79-3
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ERGOTAMINE TARTRATE
CAS Registry Number: 379-79-3
Synonyms: (SANSS 1983 Synonyms) Ergotamine Bitartrate; Gotamine
Tartrate; Gynergen; Neo-ergotin; Ergotaman-31,6',18-Trione,
12'-Hydroxy-2'-Methyl-5'-(PhenyImethy1)-, (5 ' .alpha.)-, [R-(R*,R*)]-
2,3-Dihydroxybutanedioate (2:1) (Salt); Ergam; Ergate; Ergomar; Etin; Exmigra;
Rigetamin; Secagyn; Secupan; Ergotamine, Tartrate (2:1)(Salt); Component of
Cafergot
Chemical Formula: C^N^O^.C^
Molecular Weight: 1313.56
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD.. oral (rat,
rabbit) 1 mg/kg (»NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 397°F, 203°C, decomposes (Merck 1983, p. 529)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 379-79-3
Page 2 of 3
ERGOTAMINE TARTRATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: 1 g/500 mL (Merck 1983, p. 529)
Appearance and Odor: Powder or liquid forms available as drugs (Gilman
1985, p. 938).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Protect from light and heat
(Merck 1983, p. 529)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of nitrogen oxides (Sax 1984, p. 1295).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Oilman 1985, p. 938)
Skin: Not Found
Ingestion: Yes (NIOSH/RTECS 1983, p. 209)
-------
CAS Registry Number: 379-79-3
Page 3 of 3
ERGOTAMINE TARTRATE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): High oral toxicity and a
convulsant in humans (Sax 1984, p. 1295).
Signs and Symptoms of Exposure: Nausea and vomiting occur in some
patients after oral administration. Weakness in the legs is common and
muscle pains in the extremities may occur. Numbness and tingling of the
fingers and toes may also occur (Gilman 1985, p. 938).
Medical Conditions Generally Aggravated by Exposure: People with liver
damage are at a greater risk (Gilman 1985, p. 937).
Emergency and First Aid Procedures: (Non-Specific -- Alkaloid,
n.o.s.) Move victim to fresh air; call emergency medical care. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Speed in removing material
from skin is of extreme importance. Remove and isolate contaminated
clothing and shoes at the site. Keep victim quiet and maintain normal
body temperature. Effects may be delayed; keep victim under observation
(DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
The major uses of the ergot alkaloids fall into two categories:
applications in obstetrics and treatment of migraine headaches (Gilman
1985, p. 937).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Alkaloid, n.o.s.) Keep unnecessary people away; isolate
hazard area and deny entry. Stay upwind; keep out of low areas. Wear
positive pressure breathing apparatus and special protective clothing. Do not
touch spilled material; stop leak if you can do so without risk. Use water
vapor to reduce vapors. Absorb spills with sand or other nonconibustible
absorbent material. Small dry spills: with clean shovel place material into
clean, dry container and cover; move containers from spill area. For large
spills, dike far ahead of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 465-73-6
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ISODRIN
CAS Registry Number: 465-73-6
Synonyms: 1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-Hexachloro-
l,4,4a,5,8,°8a-Hexahydro-, endo,endo-; Compound 711; ENT 19,244; Experimental
Insecticide 711; 1,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-Hexahydro-l,4; 5,8-
endo,endo-Dimethanonaphthalene; 1,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-
Hexahydro-endo,endo-1,4:5,8-Dimethanonaphthalene; 1,4:5,8-Dimethanonaphthalene,
1,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-Hexahydro-, (1 alpha, 4 alpha, 4a beta,
5 beta, 8 beta, 8a beta)-; SD 3418
Chemical Formula: C,.H0C1,
lz ci o
Molecular Weight: 364.90
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: ID oral (rat) 7
mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): Not Found
Vapor Pressure (mraHg): Not Found
Melting Point: 464-468°F, 240-242°C (Sax 1984, p. 1641)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 465-73-6
Page 2 of 3
ISODRIN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Not Found
Appearance and Odor: Solid (*Hawley 1977)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Material is related to aldrin (*Gosselin
1976). (Non-Specific -- Aldrin) Extinguish by using water spray, dry
chemical, foam, or carbon dioxide. Use water to keep fire exposed
containers cool (NFPA 1984, p. 49-13).
Special Fire Fighting Procedures: (Non-Specific -- Aldrin) Wear full
protective clothing (NFPA 1984, p. 49-13) including positive pressure
breathing apparatus. Move container from fire area if you can do so
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: (Non-Specific -- Aldrin) This
material may burn but may not ignite readily. Container may explode in
heat of fire. Fire and runoff from fire control water may produce
.irritating or poisonous gases (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*White-Stevens 1971)
Stable:
Conditions to Avoid: Reactions induced by light or acid
("White-Stevens 1971)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Material is related to aldrin
(*Gosselin 1976). (Non-Specific -- Aldrin) When heated to decomposition
it emits toxic fumes of chlorine (Sax 1984, p. 153).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 465-73-6
Page 3 of 3
ISODRIN
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Non-Specific -- Aldrin)
(Sax 1984, p. 153)
Skin: Yes (Sax 1984, p. 1641)
Ingestion: Yes (Sax 1984, p. 1641)
Health Hazards (Acute, Delayed, and Chronic): It is classified as
extremely toxic. Probable oral lethal dose for humans is 5-50 mg/kg or
between 7 drops and 1 teaspoonful for a 70 kg (150 Ib.) person. It causes
renal damage and hyperactivity of sympathetic nervous system (*Gosselin
1976).
Signs and Symptoms of Exposure: Symptoms experienced are similar to
poisoning by dieldrin and aldrin, including overall discomfort, headache,
nausea, vomiting, dizziness, tremors, convulsions, rise in blood pressure,
fever, disturbances in sleep and behavior, and rapid heartbeat. Death
from respiratory arrest may occur in coma (*Gosselin 1976, *Merck 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Procedures are similar to those
for dieldrin and aldrin poisoning (*Gosselin 1976). Move victim to fresh
air; call emergency medical care. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. In case of contact
with material, immediately flush skin or eyes with running water for at
least 15 minutes. Speed in removing material from skin is of extreme
importance. Remove and isolate contaminated clothing and shoes at the
site. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
No longer used as a pesticide (*NIOSH/RTECS 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Material is related to aldrin (*Gosselin 1976). (Non-Specific -- Aldrin)
Stay upwind; keep out of low areas. Ventilate closed spaces before
entering them. Wear positive pressure breathing apparatus and special
protective clothing. Remove and isolate contaminated clothing at the
site. Do not touch spilled material; stop leak if you can do it without
risk. Use water spray to reduce vapors. Small spills: take up with sand
or other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry containers and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 470-90-6
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CHLORFENVINFOS
CAS Registry Number: 470-90-6
Synonyms: Supona; 2,4-Dichloro-alpha-(Chloromethylene)Benzyl Diethyl
Phosphate; 2-Chloro-l-(2,4-Dichlorophenyl)Ethenyl Diethyl Ester Phosphoric
Acid; 2-Chloro-l-(2,4-Dichlorophenyl)Vinyl Diethyl Phosphate; 4072; Benzyl
Alcohol, 2,4-Dichloro-alpha-(Chloromethylene)-, Diethyl Phosphate;
beta-2-Chloro-l-(2',4'-Dichlorophenyl)Vinyl Diethyl Phosphate; Birlan;
Birlane; C8949; Chlofenvinphos; Chlorofenvinphos; Chlorphenvinfos;
Chlorphenvinphos; Compund 4072; CVP; CVP (Pesticide); Dermaton; Diethyl
l-(2,4-Dichlorophenyl)-2-Chlorovinyl Phosphate; Diethyl 2-Chloro-l-
(2,4-Dichlorophenyl)Vinyl Phosphate; ENT 24969; GC 4072; GS 4072; QMS 1328;
Phosphoric Acid, 2-Chloro-l-(2,4-Dichlorophenyl)Ethenyl Diethyl Ester;
Phosphoric Acid, 2-Chloro-l-(2,4-Dichlorophenyl)Vinyl Diethyl Ester; Sapecron;
SD 4072; Shell 4072; Supone; Vinyphate
Chemical Formula: C H .CUO.P
Molecular Weight: 359.56
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LDcn oral (rat) 10
mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 333-338°F, 167-170°C at 0.5 mmHg (^Worthing 1979)
Specific Gravity (H 0=1): 1.36 at 15.5°C/16.5°C (^Worthing 1979)
Vapor Pressure (mmHg): 4.0 x 10"6 at 20°C (^Worthing 1979)
Melting Point: -2 to -9°F; -19 to -23°C (^Worthing 1979)
-------
CAS Registry Number: 470-90-6
Page 2 of 4
CHLORFENVINFOS
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 145 mg/liter at 23°C (^Worthing 1979).
Appeacance and Odor: Amber-colored liquid with mild chemical odor
(^Worthing 1979; *Spencer 1973).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Organophosphorus Pesticide,
Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray,
or foam. Large fires: water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) Move container from fire area if you can do it
without risk. Fight fire from maximum distance. Dike fire control water
for later disposal; do not scatter the material. Wear positive pressure
breathing apparatus and special protective clothing (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) This material may burn but does not ignite
readily. Container may explode in heat of fire. Fire and runoff from
fire control water may produce irritating or poisonous gases (DOT 1984,
Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes, when stored in glass or polyethylene lined
containers (^Worthing 1979)
Conditions to Avoid: Alkaline aqueous solutions (*Merck 1976)
Incompatibility (Materials to Avoid): Iron, steel, and brass
(^Worthing 1979).
-------
CAS Registry Number: 470-90-6
Page 3 of 4
CHLORFENVINFOS
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) (DOT 1984,
Guide 55)
Skin: Yes (Hayes 1982, p. 396)
Ingestion: Yes (Hayes 1982, pp. 396-97)
Health Hazards (Acute, Delayed, and Chronic): Acute: cholinesterase
inhibitor which affects central nervous system. Severe illness or death
possible (Hayes 1982, pp. 396-397). Convulsions or coma and death
(-Gosselin 1976).
Signs and Symptoms of Exposure: Symptoms typical of cholinesterase
poisoning. Nausea is often first symptom, with vomiting, abdominal
cramps, diarrhea, and excessive salivation. Headache, giddiness,
weakness, tightness in chest, blurring of vision, pinpoint pupils, loss of
muscle coordination, and difficulty breathing. Convulsions and coma
precede death (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Organophosphorus
Pesticide, Liquid, n.o.s.) Move victim to fresh air; call emergency
medical care. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 470-90-6
Page 4 of 4
CHLORFENVINFOS
SECTION VI -- USE INFORMATION
Used for control of ticks, flies, lice, and mites on cattle and for
blowfly, lice, ked, and itchmite on sheep ("Farm Chemicals Handbook
1980). Controls fleas and mites on dog; do not use on cats. Used on
organic wastes and breeding places of fly larvae, including diary barns
(*Rossoff 1974; Hayes 1982, p. 396). Also used as a foliage insecticide
for potatoes, rice, maize, and sugar cane. Used to control soil insects,
i.e., rootflies, rootworms, and cutworms (^Spencer 1973).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) In case of
spill or leak, do not touch spilled material; stop leak if you can do it
without risk. Use water spray to reduce vapors. Small spills: take up
with sand or other non-combustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal. Keep unnecesary people away; isolate hazard area and deny
entry. Stay upwind; keep out of low areas. Ventilate closed spaces
before entering them. Wear positive pressure breathing apparatus and
special protective clothing. Remove and isolate contaminated clothing at
the site (DOT 1984, Guide 55).
-------
CAS Registry Number: 502-39-6
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- METHYLMERCURIC DICYANAMIDE
CAS Registry Number: 502-39-6
Synonyms: (Cyanoguanidino)Methylmercury; Agrosol; Cyano(Methylmercuri)
Guanidine; Guanidine, Cyano(Methylmercurio)-; Guanidine, Cyano-, Methylmercury
Deriv; Mercury, (3-Cyanoguanidino)Methyl-; Mercury, (Cyanoguanidinato)Methyl-;
Mercury, (Cyanoguanidinato-N1)Methyl-; Methyl Mercuric Dicyandiamide;
Methylmercuric Cyanoguanidine; Methylmercuric Dicyanamide; MMD; Morsodren;
Morton EP-227; Morton Soil Drench; Morton Soil-Drench-C; N-Cyano-N1-(Methyl-
mercury) Guanidine; Pano-Drench; Panp-Drench 4; Panodrin A-13; Panogen; Panogen
15; Panogen 43; Panogen 8; Panogen PX; Panogen Turf Spray; Panogen (Old);
Panospray 30; R 8; R 8 (Fungicide); MEMA; Methylmercuric Dicyandiamide;
Methylmercury dicyandiamide; Panogen Turf Fungicide
Chemical Formula: C0H,HgN.
JO H
Molecular Weight: 298.72
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Air: TWA 0.01 mg/m3; ceiling concentration 0.04 mg/m3
(NIOSH/RTECS 1983, Volume 2, p. 662)
ACGIH TLV: TWA 0.01 mg (Hg)/m3; STEL (ceiling) 0.03 mg (Hg)/m3
(skin) (NIOSH/RTECS 1983, Volume 2, p. 662)
IDLH: Not Found
Other Limits Recommended: IDLH for organo (alkyl) mercury compounds is
10 mg/m3 (NIOSH/OSHA 1978, p. 144). Toxicity information: LD5Q oral
(mouse) 20 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): 6.5 x 10"5 at 35°C (*Martin and Worthing 1974)
Melting Point: 313°F, 156°C (*Hawley 1981)
-------
CAS Registry Number: 502-39-6
Page 2 of 4
METHYLMERCURIC DICYANAMIDE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 2.17 g/100 ml at room temperature (*Martin and
Worthing 1974); soluble (Hawley 1981, p. 295)
Appearance and Odor: Crystals (-Hawley 1981)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Mercury-Based Pesticide,
n.o.s.) This material may burn but will not ignite readily. For small
fires, use dry chemical, carbon dioxide, water spray, or foam. For large
fires, use water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Mercury-Based
Pesticide, n.o.s.) Fight fire from maximum distance. Dike fire control
water for later disposal. Wear positive pressure breathing apparatus and
special protective clothing (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: (Non-Specific -- Mercury-Based
Pesticide, n.o.s.) This material may burn but does not ignite readily.
Container may explode in heat of fire. Fire and runoff from fire control
water may produce irritating or poisonous gases (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Martin and Worthing 1974)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of mercury and nitrogen oxides (Sax 1984, p.
1868).
-------
CAS Registry Number: 502-39-6
Page 3 of 4
METHYLMERCURIC DICYANAMIDE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Gosselin 1984, p. 11-137)
Skin: Yes (Gosselin 1984, p. 11-137)
Ingestion: Yes (Sax 1984, p. 1868)
Health Hazards (Acute, Delayed, and Chronic): Methylmercuric
dicyanamide is extremely toxic to humans. The probable lethal dose for
humans is 5-50 mg/kg of body weight (between 7 drops and one teaspoon for
a 150 Ib. person) (*Gosselin 1984). Humans may be poisoned by feeding on
the flesh of animals which have ingested this fungicide ("Clark 1981).
Eating treated seeds may also cause poisoning. The poisoning may show
• delayed manifestations on the nervous system. Patients frequently become
gradually worse after their illness is recognized and exposure is stopped
(Hayes, 1982, p. 21). This 'compound is a strong skin irritant and
produces blisters and other dermatitis ("Gosselin 1976).
Signs and Symptoms of Exposure: Prolonged exposure to skin may produce
blisters ("Gosselin 1984). In the case of ingestion there is nausea and
abdominal pain. Vomiting and diarrhea may occur. Burning or prickling of
the lips, tongue, and extremities. The patient may be confused,
hallucinate, be irritable, have disturbed sleep, lose muscular
coordination and lose memory. Visual fields may narrow concentrically;
emotional instability may occur as well as inability to concentrate, with
stupor and coma ("Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Mercury-Based
Pesticide, n.o.s.) Move victim to fresh air; call emergency medical
care. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 502-39-6
Page 4 of 4
METHYLMERCURIC DICYANAMIDE
SECTION VI -- USE INFORMATION
Fungicide; a seed, soil, and turf treatment (Buchel 1983, p. 249)
especially for cereals, sorghum, sugar beets, cotton, and flax (Hayes
1982, p. 20). Not registered as a pesticide in the U.S. (USEPA/Pesticide
Index 1985).
SECTION VII --PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Mercury-Based Pesticide n.o.s.) Keep unnecessary people
away; isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Ventilate closed spaces before entering. Wear positive pressure
breathing apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site. Do not touch spilled material. Use
water to reduce vapors. In event of spill or leak: take up with
absorbent material and. place in containers with covers. Small dry spill:
with clean shovel place material into clean, dry container and cover; move
containers from spill area. Dike far ahead of spill if large (DOT 1984,
Guide 55).
-------
CAS Registry Number: 504-24-5
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PYRIDINE, 4-AMINO-
CAS Registry Number: 504-24-5
Synonyms: 4-Aminopyridine; 4-AP; 4-Pyridinarhine; 4-Pyridylamine; Amino-4
Pyridine; Avitrol; gamma-Arainopyridine; MI-W-3; p-Arainopyridine; Phillips
1861; Pyridine, 4-Amino-; VMI 10-3
Chemical Formula: CCH,N0
3 D /
Molecular Weight: 94.13
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD. oral (man)
0.59 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 524.3°F, 273.5°C (*Hawley 1977)
Specific Gravity (H20=l): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 318.0°F, 158.9°C (*Hawley 1977)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Moderately soluble (*Farm Chemicals Handbook 1981)
Appearance and Odor: White crystalline material with no odor (*Farm
Chemicals Handbook 1981).
-------
CAS Registry Number: 504-24-5
Page 2 of 3
PYRIDINE, 4-AMINO-
SECTION 111 -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: The material may burn but will not ignite
easily. To extinguish use dry chemical, carbon dioxide, water spray, fog,
or foam.(DOT 1984, Guide 55).
Special Fire Fighting Procedures: Wear positive pressure self-
contained breathing apparatus and special protective clothing. Move
container from fire area if you can do so without risk. Fight fire from
maximum distance possible. Control runoff water with dikes and prevent
material from scattering (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Material may produce irritating or
poisonous gases in fire. Runoff from fire control water may give off
poisonous gases (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (*Farm Chemicals Handbook 1981)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: It may emit irritating or
poisonous gases in fire conditions (DOT 1984, Guide 55).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Yes (*DOT 1984)
Ingestion: Yes (Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Material may be fatal if
inhaled, swallowed or absorbed through skin. Contact may cause burns to
skin and eyes (*DOT 1984). Material affects neural transmission. In
sufficient concentrations, material may cause metabolic acidosis,
respiratory arrest, and cardiac arrhythmias (*Rumack 1975 to Present).
-------
CAS Registry Number: 504-24-5
Page 3 of 3
PYRIDINE, 4-AMINO-
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Rapid onset of disagreeable taste,
immediate burning of throat, and abdominal discomfort, in addition to
weakness, dizziness, disorientation, and seizures may occur. Delayed
symptoms of oral ingestion include elevated liver enzymes, and respiratory
arrest (-Rumack 1975 to Present).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If breathing is difficult, give oxygen. In case
of contact with material, immediately flush skin or eyes with running
water for at least fifteen minutes (-DOT 1984).
SECTION VI -- USE INFORMATION
Material is used as an avicide (bird repellant), an intermediate and as a
fixer in some textile dyes ("Rumack 1975 to Present, *Hawley 1977).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Keep unnecessary people away; isolate the hazardous area and deny entry.
Stay'upwind. Wear positive pressure breathing apparatus and special
protective clothing. Do not touch spilled material; stop leak if possible
without risk. Use water spray to reduce vapors. Small spills: absorb
with sand or other noncombustible absorbent material and place into
containers for later disposal. Small dry spills: with clean shovel place
material into clean, dry container and cover; move containers from spill
area. Large spills: dike far ahead of spill for later disposal (*DOT
1984).
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CAS Registry Number: 505-60-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- MUSTARD GAS
CAS Registry Number: 505-60-2
Synonyms: Sulfide, bis(2-Chloroethyl); 1,I1-Thiobis(2-Chloroethane);
l-Chloro-2-(beta-Chloroethylthio)Ethane; 2,2*-Dichlorodiethyl Sulfide;
2,2'-Dichlorodiethyl Sulphide; 2,2'-Dichloroethyl Sulfide; 2,2'-Dichloroethyl
Sulphide; beta, beta1-Dichloroethyl Sulfide; beta, beta'rDichloroethyl
Sulphide; beta,beta-Dichlor-Ethyl-Sulphide; Bis(2-Chloroethyl) Sulfide;
Bis(2-Chloroethyl) Sulphide; Bis(beta-Chloroethyl) Sulfide;
Bis(beta-Chloroethyl) Sulphide; Di-2-Chloroethyl Sulfide; Di-2-Chloroethyl
Sulphide; Distilled Mustard; Ethane, 1,l'-Thiobis(2-Chloro-; H; HD; Kampfstoff
"Lost"; Mustard HD; Mustard Vapor; Mustard, Sulfur; S Mustard; S-Lost;
S-Yperite; Schwefel-Lost; Sulfur Mustard; Sulfur Mustard Gas; Sulphur Mustard;
Sulphur Mustard Gas; Yellow Cross Liquid; Yperite
Chemical Formula: C.H.C1.S
40 /
Molecular Weight: 159.08
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC.. inhalation
(human) 0.149 mg/liter for 10 minutes (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 419-423°F, 215-217°C (*Merck 1976)
Specific Gravity (H20=l): 1.274 at 20°C/4°C (liquid) (*Merck 1976)
Vapor Pressure (mmHg): 0.090 at 30°C (''-Merck 1976)
Melting Point: 55-57°F, 13-14°C (*Merck 1976)
Vapor Density (AIR=1): 5.4 (*Sax 1975)
-------
CAS Registry Number: 505-60-2
Page 2 of 4
MUSTARD GAS
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.68 g/liter at 25°C (-IARC 1972-1985); very
sparingly soluble in water (Merck 1983, p. 904).
Appearance and Odor: Colorless oily liquid (-IARC 1972-1985) with a
weak, sweet odor (*Merck 1976) or garlic-like odor (U.S. Army 1975, p.
3-8).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 221°F, 105°C (*Sax 1975)
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Extinguish with water, foam, dry chemical, or
carbon dioxide ("Sax 1975).
Special Fire Fighting Procedures: Protective clothing and
self-contained breathing apparatus required in presence of mustard gas
("Sax 1975). Cool all affected containers with flooding quantities of
water. Apply water from as far a distance as possible (Student 1981, p.
358).
Unusual Fire and Explosion Hazards: Can be ignited by large explosive
charge. When heated to decomposition, emits highly toxic fumes of oxides
of sulfur and chlorine containing compounds. Reacts with water or steam
to produce toxic and corrosive fumes (*Sax 1975). Containers may rupture
violently in a fire (Student 1981, p. 358).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes; hydrolyzed in aqueous solution (*IARC
1972-1985)
Stable:
Conditions to Avoid: High heat; contact with acid or acid fumes
(••Sax 1984, p. 482).
Incompatibility (Materials to Avoid): Incompatible with bleaching
powder (Sax 1984, p. 482). Reacts violently with oxidizing materials.
Reacts with water or steam to produce toxic and corrosive fumes (*Sax
1975).
-------
CAS Registry Number: 505-60-2
Page 3 of 4
MUSTARD GAS
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Decomposition or Byproducts: Emits highly toxic fumes of
oxides of sulfur and chlorine containing compounds when heated to
decomposition or on contact with acid or acid fumes (*Sax 1974)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Sax 1975)
Skin: Yes (--Sax 1975)
Ingestion: Yes (-Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): The median lethal dosage
is 1500 mg-minute/m3 for inhalation and 10,000 mg-minute/m3 for skin
absorption (masked personnel). The median incapacitating dosage is 200
mg-minute/m3 for eye injury and 2000 mg-minute/m3 for skin absorption
(masked personnel). Wet skin absorbs more material than dry skin (U.S.
Army 1975, p. 3-8). May cause death or permanent injury after very short
exposure to small quantities (*Sax 1975). It is a blistering gas and is
highly irritating to eyes, skin, and lungs. Pulmonary lesions are often
fatal (Sax 1984, pp. 461-462). Permanent eye damage and severe
respiratory impairment. It is a carcinogen (Merck 1983, p. 904).
Signs and Symptoms of Exposure: May cause conjunctivitis and
blindness. In 1-12 hours there may be coughing, swollen eyelids, reddened
skin, and severe itching. There may be swelling and destruction of tissue
in the respiratory tract and exposed skin. Ingestion may cause nausea and
vomiting ("Merck 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Remove patient from contaminated
atmosphere as rapidly as possible. Irrigate exposed eyes with water for
at least 15 minutes. Wash exposed areas of the skin twice with soap and
water. Local lesions should be cleaned and treated similarly to burns
with emollients ("Rumack 1975 to Present).
-------
CAS Registry Number: 505-60-2
Page 4 of 4
MUSTARD GAS
SECTION VI -- USE INFORMATION
It has been used as a chemical warfare agent (*IARC 1972-1985) and as a
chemical intermediate. It is not produced commercially in the U.S. (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
To clean up a spill, cover with up to 15 percent calcium hypochloride.
Place in container; neutralize after 12 hours if necessary ("Rumack 1975
to Present). Keep sparks, flames, and other sources of ignition away.
Keep material out of water sources and sewers. Attempt to stop leak if
without hazard. Use water spray to knock down vapors. Avoid breathing
vapors and bodily contact with the material. Keep upwind. Wear self-
contained breathing apparatus and full protective clothing. Wash away any
material which may have contacted the body with copious amounts of soap
and water. Downwind evacuation must be considered (Student 1981, p. 358).
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CAS Registry Number: 506-61-6
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- POTASSIUM SILVER CYANIDE
CAS Registry Number: 506-61-6
Synonyms: Argentate(l-), bis(Cyano-C)-, Potassium; Argentate(l-),
Dicyano-, Potassium; Argentates(I) (Sol), Dicyano-; Potassium Argentocyanide;
Potassium bis(Cyano-C)Argentate(l-); Potassium Dicyanoargentate; Potassium
Dicyanoargentate (KAg(CN) ); Potassium Dicyanoargentate(1-); Potassium
Dicyanoargentate(I); Potassium Silver Cyanide (KAg(CN).); Silver Potassium
Cyanide [AgK(CN)2]
Chemical Formula: C AgN »K
Molecular Weight: 199.01
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: TWA 0.01 mg/m3 as Ag (soluble silver
salts) (-ACGIH 1980); TWA 5.0 mg/m3 as CN (skin; cyanides) (ACGIH 1985,
p. 14). Toxicity information: LD oral (rat) 21 mg/kg (*NIOSH/RTECS
1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): 2.36 at 25°C (*Hawley 1977)
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 506-61-6
Page 2 of 4
POTASSIUM SILVER CYANIDE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Soluble (*Merck 1976)
Appearance and Odor: White crystals (*Merck 1976)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Cyanide, Inorganic, n.o.s.)
Use dry chemical, carbon dioxide, water spray, or foam for small fire, and
water spray, fog, or foam for large fires. Move containers of this
material away from fire area if this can be done without risk (DOT 1984,
Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Cyanide, Inorganic,
n.o.s.) Isolate hazard area and deny entry. Stay upwind; keep out of low
areas. Ventilate closed spaces before entering them. Wear positive
pressure breathing apparatus and special protective clothing. Fight fire
from maximum distance. Dike fire control water for later disposal. Do
not scatter the material (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition,
potassium silver cyanide emits very toxic fumes of cyanide and nitrogen
oxides (Sax 1984, p. 2282).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Light (*Merck 1976)
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
potassium silver cyanide emits very toxic fumes of cyanide and nitrogen
oxides (Sax 1984, p. 2282).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 506-61-6
Page 3 of 4
POTASSIUM SILVER CYANIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Rumack 1975 to Present)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (-Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): The primary health
hazard is as a cyanide (*Gosselin 1976). (Non-specific -- Cyanide,
Inorganic, n.o.s.). It is poisonous and may be fatal if inhaled,
swallowed or absorbed through the skin. Fire may produce irritating or
poisonous gases (DOT 1984, Guide 55).
Signs and Symptoms of Exposure: As a cyanide, massive doses may
produce, without warning, sudden loss of consciousness and prompt death
from respiratory arrest. Smaller but still lethal doses result in illness
that may be prolonged for 1 or more hours. Other symptoms may include
numbness in throat, salivation, nausea, anxiety, dizziness, irregular
breathing, odor of bitter almonds may be noted on breath, blood pressure
may rise, slowing of the heart beat, sensation of constriction in the
chest, unconsciousness followed by violent convulsions and paralysis
(*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Cyanide,
Inorganic, n.o.s.) Move victim to fresh air; call emergency medical
care. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Potassium silver cyanide is used in silver plating, as a bactericide
(*Merck 1976), and in the manufacture of antiseptics (*Hawley 1977). Not
registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985).
-------
CAS Registry Number: 506-61-6
Page 4 of 4
POTASSIUM SILVER CYANIDE
SECTION VH -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation or skin contact (see Section V above). (Non-Specific --
Cyanide, Inorganic, n.o.s.) Wear positive pressure breathing apparatus
and protective clothing. Do not touch spilled materials; stop leak if you
can do so without risk. Use water spray to reduce vapors. Small spills:
absorb with sand or other noncombustible absorbent material and place into
containers for later disposal. Small dry spills: with clean shovel place
material into clean, dry container and cover; move containers from spill
area. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 55).
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CAS Registry Number: 506-68-3
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CYANOGEN BROMIDE
CAS Registry Number: 506-68-3
Synonyms: Bromine Cyanide; Bromocyan; Bromocyanide; Bromocyanogen;
Campilit; Cyanobromide; Cyanogen Monobromide; TL 822
Chemical Formula: CBrN
Molecular Weight: 105.93
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Suggested TLV less than 0.5 ppm (-Patty
1963). Toxicity information: LC. inhalation (human)
0.398 mg/liter/10 minutes (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 142°F, 61.4°C (*Weast 1979)
<2
Specific Gravity (H 0=1): 2.015 at 20°C/4°C (*Merck 1976)
Vapor Pressure (mmHg): 92 at 20°C (*Patty 1963)
Melting Point: 126°F, 52°C (*Merck 1976)
Vapor Density (AIR=1): 3.62 (*Patty 1963)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (*Weast 1979)
Appearance and Odor: Colorless to white cubes or needle-like crystals
with a penetrating odor (*Merck 1976; *Sax 1979; *NFPA 1978; *Patty 1963)
-------
CAS Registry Number: 506-68-3
Page 2 of 4
CYANOGEN BROMIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Noncombustible (NFPA 1978, p. 49-34)
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Extinguish fire using agent suitable for type
of surrounding fire. Material itself does not burn or burns with
difficulty. Use foam, carbon dioxide, or dry chemical. Cool all affected
containers with flooding quantities of water. Do not use water on
material itself. If large quantities of combustibles are involved, use
water in flooding quantities as spray and fog. Use water spray to absorb
vapors. Keep material out of water sources and sewers. Use water spray
to knock down vapors (Student 1981, p. 158).
Special Fire Fighting Procedures: Wear full protective clothing.
Avoid direct water contact as it will cause cyanogen bromide to decompose,
releasing toxic gases (*NFPA 1978). Avoid breathing vapors or dusts; keep
upwind; wear self-contained breathing apparatus (Student 1981, p. 158).
Unusual Fire and Explosion Hazards: Cyanogen bromide is not
combustible itself, but impure cyanogen bromide decomposes rapidly and
tends to explode (*Merck 1976). A violent reaction may take place on
contact with large quantities of acid (*NFPA 1978) . Vapors are highly
irritating (-Merck 1976).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes, impure material decomposes rapidly and tends
to explode (*Merck 1976)
Stable:
Conditions to Avoid: Avoid physical damage, contact with acids or
water, and store away from a location where water may be needed for
fire control (*NFPA 1978).
Incompatibility (Materials to Avoid): Water, acids (-NFPA 1978)
Hazardous Decomposition or Byproducts: When material is heated to
decomposition, it emits very toxic fumes of cyanide and bromide (Sax 1984,
p. 825).
-------
CAS Registry Number: 506-68-3
Page 3 of 4
CYANOGEN BROMIDE
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*NIOSH 1979)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): Super toxic; probable
oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7
drops) for a 70 kg (150 Ib.) person (*Gosselin 1976). Vapors are highly
irritant and very poisonous (''"Merck 1976).
Signs and Symptoms of Exposure: Cyanogen bromide's toxic action
resembles that of hydrocyanic acid; it has a pronounced irritant effect
and high concentrations may cause pulmonary edema (*Encyc Occupat Health
and Safety 1971). High concentrations produce excessive respiration
(causing increased uptake of cyanide), then labored breathing, paralysis,
unconsciousness, convulsions and respiratory arrest. Headache, dizziness,
nausea, and vomiting may occur with lesser concentrations. Chronic
exposure may cause fatigue and weakness (*Merck 1976). Patients may
experience confusion, anxiety, an initial rise in blood pressure with a
decreased heart beat followed by an increased heart beat; cyanosis is not
a consistent finding, in fact, the patient may be reddish. An odor of
bitter almonds on the patient's breath may be present (*Rumack 1975 to
Present).
Medical Conditions Generally Aggravated by Exposure: Individuals with
chronic diseases of the kidneys, respiratory tract, skin, or thyroid are
at greater risk of developing toxic cyanide effects (*Encyc Occupat Health
and Safety 1983).
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
-------
CAS Registry Number: 506-68-3
Page 4 of 4
CYANOGEN BROMIDE
SECTION VI -- USE INFORMATION
Cyanogen bromide is used in organic synthesis, as a fumigant, a pesticide,
in cellulose technology, and in gold-extraction (*Patty 1963). Not
registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Protective clothing including impervious hand protection should be worn
(*Encyc Occupat Health and Safety 1971). Wear positive pressure breathing
apparatus. Do not touch spilled material; stop leak if you can do it
without risk. Use water spray to reduce vapors. Small spills: take up
with sand or other noncombustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 506-78-5
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CYANOGEN IODIDE
CAS Registry Number: 506-78-5
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 545): Iodine
Cyanide; Jodcyan
Chemical Formula: CIN
Molecular Weight: 152.92
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 5.0 mg (cyanide)/ra3 (skin) (ACGIH 1983, p. 16)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD.. oral (cat) 18
mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 2.84 (Hawley 1981, p. 295)
Vapor Pressure (mmHg): 1 at 25.2°C (Sax 1984, p. 826)
Melting Point: 295.7°F, 146.5°C (Hawley 1981, p. 295)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly (Weast 1980, p. C-259)
Appearance and Odor: White needles with a very pungent odor (Merck
1983, p. 385).
-------
CAS Registry Number: 506-78-5
Page 2 of 4
CYANOGEN IODIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Cyanide or Cyanide Mixture,
Dry) Small fires: dry chemical, carbon dioxide, water spray, or foam.
Large fires: water spray, fog, or foam. Move container from fire area if
you can do so without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (DOT 1984,
Guide 55).
I
Special Fire Fighting Procedures: (Non-Specific -- Cyanide or Cyanide
Mixture, Dry) Keep unnecessary people away; isolate hazard area and deny
entry. Stay upwind; keep out of low areas. Ventilate closed spaces
before entering them. Wear positive pressure breathing apparatus and
special protective clothing. Remove and isolate contaminated clothing at
the site (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of nitrogen oxides, cyanide, and iodide (Sax 1984,
p. 826).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Phosphorus (Sax 1984, p. 826)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of nitrogen oxides, cyanide, and iodide (Sax
1984, p. 826).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 506-78-5
Page 3 of 4
CYANOGEN IODIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: No (Merck 1983, p. 385)
Skin: Yes (Sax 1984, p. 826, p. 822)
Ingestion: Yes (Sax 1984, p. 826, p. 822)
Health Hazards (Acute, Delayed, and Chronic): Causes convulsions,
paralysis and death from respiratory failure (Merck 1983, p. 385). Highly
toxic; strong irritant to eyes and skin (Hawley 1981, p. 295).
(Non-Specific -- Cyanide or Cyanide Mixture, Dry): Poisonous, may be
fatal if swallowed or absorbed through skin. Contact may cause burns to
the skin and eyes. Fire may produce irritating or poisonous gases (DOT
1984, Guide 55).
Signs and Symptoms of Exposure: Can cause death due to respiratory
failure (Merck 1983, p. 385). Health effects are similar to cyanides and
iodides (Sax 1984, p. 826). Upon ingestion, a bitter, acrid, burning
taste is sometimes noted. Other symptoms are anxiety, confusion,
dizziness, giddiness, rapid and difficult breathing, palpitations,
tightness in chest, unconsciousness, violent convulsions and death
(Gosselin 1984, p. III-127).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Cyanide or
Cyanide Mixture, Dry) Move victim to fresh air; call emergency medical
care. If not breathing, give artificial,respiration. If breathing is
difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Taxidermists' preservatives (Hawley 1981, p. 295). Generally for
destroying all lower forms of life (Merck 1983, p. 385).
-------
CAS Registry Number: 506-78-5
Page 4 of 4
CYANOGEN IODIDE
SECTION VII --PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Cyanide or Cyanide Mixture, Dry) Wear positive pressure
breathing apparatus and special protective clothing. Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. Small
dry spills: with clean shovel, place material into clean, dry container
and cover; move containers from spill area. Large spills: dike far ahead
of spill for later disposal (DOT 1984, Guide 55).
COMMENTS
Sources searched but no information found:
NIOSH/OSHA 1978
NFPA 1984
Student 1981
Weiss 1980
CHRIS 1978
Doull 1980
Clayton and Clayton 1981-82
Arena 1979
Encyc Occupat Health and Safety 1983
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
-------
CAS Registry Number: 509-14-8
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- TETRANITROMETHANE
CAS Registry Number: 509-14-8
Synonyms: Methane, Tetranitro; NCI-C55947; Tetan; TNM
Chemical Formula: CN.CL
4 8
Molecular Weight: 196.04
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 1 ppm (*NIOSH/RTECS 1985)
ACGIH TLV: 1 ppm, 8 mg/ra3 (*ACGIH 1980)
IDLH: 5 ppm (NIOSH/OSHA 1978, p. 178)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 259°F, 126°C (*Merck 1976)
Specific Gravity (H20=l): 1.6380 at 20°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): 13 at 25°C (*Patty 1963)
Melting Point: 57.6°F, 14.2°C (*Weast 1979)
Vapor Density (AIR=1): 6.8 (*Patty 1963)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*Weast 1979)
Appearance and Odor: Pale yellow liquid (*Merck 1976) or colorless
oily fluid with acrid biting odor (*Patty 1963), causes tears (NIOSH/OSHA
1978, p. 178).
-------
CAS Registry Number: 509-14-8
Page 2 of 3
TETRANITROMETHANE
SECTION 111 -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Non-combustible (NIOSH/OSHA 1978, p. 178)
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Extinguish small fires with water only, no dry
chemicals or carbon dioxide. For large fires, flood the fire area with
water (DOT 1984, Guide 47).
Special Fire Fighting Procedures: Do not move cargo or vehicle if
cargo has been exposed to heat. Cool containers that are exposed to
flames with water from the side until well after fire is out. For massive
fire, use unmanned hose holder or monitor nozzles; if this is impossible,
withdraw from area and let fire burn (DOT 1984, Guide 47).
Unusual Fire and Explosion Hazards: Spontaneous chemical reaction may
produce fire. Material is a strong oxidizer. The potential for explosion
is severe, especially when exposed to heat or to powerful oxidizing or
reducing agents; or when shocked or heated ("Sax 1975). It is more easily
detonated than TNT (*Patty 1963). Impurities can also cause explosion
("Merck 1976). The material is highly sensitive; hydrocarbons exposed to
it form exceedingly sensitive explosives (*NFPA 1978).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Sax 1975)
Stable:
Conditions to Avoid: Impurities, shock, heat, and reducing agents
(*Sax 1975)
Incompatibility (Materials to Avoid): Hydrocarbons, aluminum, toluene,
cotton, aromatic nitro compounds (Sax 1984, p. 2550); alkalis, metals
(NIOSH/OSHA 1978, p. 178); and rubber (Merck 1983, p. 1321).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes of oxides of nitrogen. Shock will explode it
(*Sax 1975).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 509-14-8
Page 3 of 3
TETRANITROMETHANE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Patty 1963)
Skin: Yes (*Rumack 1975 to Present)
Ingestion: Yes (-Patty 1963)
Health Hazards (Acute, Delayed, and Chronic): Acute effects include
irritation of the eyes and respiratory passages and mild burns to the skin
(*Sax 1975). After more prolonged inhalation, headache and respiratory
distress may occur (*Patty 1963). After prolonged exposure, central
nervous system, heart, liver, and kidney damage can occur as well as
pulmonary edema (*ACGIH 1980; "Sax 1975).
Signs and Symptoms of Exposure: Symptoms include burning eyes, skin,
and mucous membranes (*Sax 1975); headache, difficulty in breathing, and
dizziness. Skin contact results in bluish discoloration of skin and
raucous membranes (cyanosis), and skin burns (NIOSH/OSHA 1978, p. 179).
Chronic signs and symptoms included weariness, and pneumonia (*ACGIH 1980).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Exposed skin should be washed
twice with soap and water. Flush eyes with water at least 15 minutes
(*Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
It is proposed as an irritant war gas ('"Merck 1976). It is used as an
oxidizing agent in rocket propellants; explosives; diesel fuel additives;
and a reagent for detecting double bonds (*SRI).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Remove all ignition sources. Ventilate area of spill or leak. Collect
for reclamation or absorb in vermiculite, dry sand, earth or a similar
material. Avoid shock and friction if liquid spills on combustible
material such as wood, or paper (*NIOSH/OSHA 1981). Use water spray to
reduce vapors. Flush area with flooding amounts of water and dike spill
for later disposal. Keep unnecessary people away; isolate hazard area and
deny entry. Stay upwind; keep out of low areas. Wear positive pressure,
self-contained breathing apparatus and full protective clothing (DOT 1984,
Guide 47).
-------
CAS Registry Number: 514-73-8
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- DITHIAZANINE IODIDE
CAS Registry Number: 514-73-8
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 1, p. 664): Benzothiazolium,
3-Ethyl-2-(5-(3-Ethyl-2-Benzothiazolinylidene)-l,3-Pentadienyl)-, Iodide;
Abminthic; Anelmid; Delvex; 3,3'-Diethylpentamethinethiacyanine Iodide;
Dilombrin; 3,3'-Diethylthiadicarbocyanine Iodide; L-01748; Omni-Passin;
Partel; Telmid; Vercidon; 3-Ethyl-2-(5-(3-Ethyl-2-Benzothiazolylidene)-
l,3-Pentadienyl)benzothiazolium Iodide; Anguifugan; Dejo; Deselmine; Dizan;
Nectocyd; Telmicid (Merck 1983, p. 492)
Chemical Formula: C0,H0/N.S0I
23 24 2 2
Molecular Weight: 519.51
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD,.0 oral (mouse)
20 mg/kg (^NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Decomposes at 248°C (Merck 1983, p. 492)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 514-73-8
Page 2 of 3
DITHIAZANINE IODIDE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Insoluble (Merck 1983, p. 492)
Appearance and Odor: Green, needle-like crystals (Merck 1983, p. 492).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Pesticide, Solid, n.o.s.)
Small fires: dry chemical, carbon dioxide, water spray or foam. Large
fires: water spray, fog, or foam. Move container from fire area if you
can do it .without risk (DOT 1984, Guide 53).
Special Fire Fighting Procedures: (Non-Specific -- Pesticide, Solid,
n.o.s.) This material may burn but does not ignite readily. Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Wear self-contained, postive pressure if
available, breathing apparatus and full protective clothing (DOT 1984,
Guide 53).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits toxic fumes of iodine, sulfur oxides, and nitrogen oxides (Sax 1984,
p. 1024).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits toxic fumes of iodine, sulfur oxides, and nitrogen oxides (Sax
1984, p. 1024).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 514-73-8
Page 3 of 3
DITHIAZANINE IODIDE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 1024)
Health Hazards (Acute, Delayed, and Chronic): Highly toxic by mouth
(Sax 1984, p. 1024). (Non-Specific -- Pesticide, Solid, n.o.s.)
Poisonous if swallowed, or if dust is inhaled (DOT 1984, Guide 53).
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Pesticide, Solid,
n.o.s.) Move victim to fresh air; call emergency medical care. Remove
and isolate contaminated clothing and shoes at the site. In case of
contact with material, immediately flush skin or eyes with running water
for at least 15 minutes (DOT 1984, Guide 53).
SECTION VI -- USE INFORMATION
Veterinary anthelmintic, sensitizer for photographic emulsions (Merck
1983, p. 492) and for insecticides (Farm Chemicals Handbook 1984, p. C-85)
Not registered as a pesticide in the U.S. (USEPA/Active Ingredients 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Pesticide, Solid, n.o.s.) Do not touch spilled material;
stop leak if you can do so without risk. Small spills: absorb with sand
or other non-combustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal (DOT 1984, Guide 53).
COMMENTS:
Sources searched but no information found:
Weast 1979
Hawley 1981
ACGIH 1984
NIOSH/OSHA 1978
Weiss 1980
Gosselin 1984
Hayes 1982
Buchel 1983
Encyc Occupat Health and Safety 1983
-------
CAS Registry Number: 534-07-6
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- BIS(CHLOROMETHYL) KETONE
CAS Registry Number: 534-07-6
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 3, p. 325) 2-Propanone,
1,3-Dichloro-; sym-Dichloroacetone; alpha,alpha1-Dichloroacetone;
alpha,gamma-Dichloroacetone; 1,3-Dichloroacetone; l,3-Dichloro-2-Propanone
Chemical Formula: CJ^Cl.O
Molecular Weight: 126.97
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(mouse) 0.027 mg/liter/2 hours (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 343°F, 173°C (Merck 1983, p. 443)
Specific Gravity (H20=l): 1.3826 at 46°C/4°C (Merck 1983, p. 443)
Vapor Pressure (mmHg): Not Found
Melting Point: 113°F, 45°C (Merck 1983, p. 443)
Vapor Density (AIR=1): 4.38 (Sax 1984, p. 464)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Soluble (Merck 1983, p. 443)
Appearance and Odor: Crystalline solid (Merck 1983, p. 443)
-------
CAS Registry Number: 534-07-6
Page 2 of 4
BIS(CHLOROMETHYL) KETONE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: For small fires, use dry chemical, carbon
dioxide, water spray, or foam. For large fires, use water spray, fog, or
foam. Move container from fire area if you can do so without risk. Fight
fire from maximum distance. Dike fire control water for later disposal;
do not scatter the material (DOT 1984, Guide 55).
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site. If water pollution occurs, notify
appropriate authorities (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits highly toxic fumes of chlorides (Sax 1984, p. 464). This material
may burn but does not ignite readily. Container may explode in heat of
fire (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits highly toxic fumes of chlorides (Sax 1984, p. 464).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 464)
Skin: Yes (DOT 1984, Guide 55)
Ingestion: Yes (Sax 1984, p. 464)
-------
CAS Registry Number: 534-07-6
Page 3 of 4
BIS(CHLOROMETHYL) KETONE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): It may be fatal if
inhaled, swallowed or absorbed through skin. Contact may cause burns to
skin and eyes. Fire may produce irritating or poisonous gases. Runoff
from fire control water may give off poisonous gases. Runoff from fire
control or dilution water may cause pollution (DOT 1984, Guide 55).
Signs and Symptoms of Exposure: It causes tearing and blistering
(Merck 1983, p. 443).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Formerly extensively used in textiles (especially polyester fabrics) and
still employed in polyurethane foams, textile backcoating and adhesives
(Gosselin 1984, p. 11-303).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation. Wear respiratory protection, eye protection and
protective clothing. In case of contact, immediately flush skin or eyes
with water (see Section V above). Do not touch spilled material; stop
leak if you can do so without risk. Use water spray to reduce vapors.
For small spills, absorb with sand or other noncombustible absorbent
material and place into containers for later disposal. Small dry spills:
with clean shovel place material into clean, dry container and cover; move
containers from spill area. For large spills, dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 534-07-6
Page 4 of 4
BIS(CHLOROMETHYL) KETONE
COMMENTS
Sources searched but no information found:
ACGIH 1983
NIOSH/OSHA 1978
Hawley 1981
Weast 1979
NFPA 1984
Student 1981
Weiss 1980
CHRIS 1978
Doull 1980
Clayton and Clayton 1981-82
Arena 1979
Encyc Occupat Health and Safety 1983
Buchel 1983
Farm Chemicals Handbook 1984
Hayes 1982
Physicians' Desk Reference 1985
-------
CAS Registry Number: 534-52-1
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- DINITROCRESOL
CAS Registry Number: 534-52-1
Synonyms? 4,6-Dinitro-o-Cresol; 2,4-Dinitro-6-Methylphenol;
2-Methyl-4,6-Dinitrophenol; 3,5-Dinitro-2-Hydroxytoluene;
6-Methyl-2,4-Dinitrocresol; Antinonin; Antinonnin; Arborol; Capsine; Chemsect
DNOC; Degrassan; Dekrysil; Detal; Dillex; Dinitro; Dinitro-o-Cresol;
Dinitrodendtroxal; Dinitrol; Dinitromethyl Cyclohexyltrienol; Dinitrosol;
Dinoc; Dinurania; Ditrosol; DN; DN-Dry Mix No. 2; DNC; DNOC; Effusan 3436;
Elgetol; Elgetol 30; Elipol; ENT 154; Extrar; Hedolit; K III; K IV; Krenite;
Kreozan; Kresamone; Krezotol 50; Sandolin A; Selinon; Toluene,
3,5-Dinitro-2-Hydroxy; Phenol, 2-methyl-4,6-dinitro
Chemical Formula: C,H,N-0C
/ o 2 o
Molecular Weight: 198.13
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 200 ug/m3 (skin) (-NIOSH 1977 to Present)
ACGIH TLV: TWA 0.2 mg/m3; STEL 0.6 mg/m3 (skin) (-ACGIH 1982)
IDLH: 5 mg/m3 (NIOSH/OSH 1980, p. 90)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 594°F, 312°C (ACGIH 1980, p. 152)
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): 5 x 10"5 (NIOSH/OSHA 1978, p. 90)
Melting Point: 190°F, 87.5°C (*Merck 1976)
Vapor Density (AIR=1): 6.82 (Sax 1984, p. 1212)
-------
CAS Registry Number: 534-52-1
Page 2 of 3
DINITROCRESOL
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.01 g in 100 ml (NIOSH/OSHA 1978, p. 90)
Appearance and Odor: Yellow odorless solid (NIOSH/OSHA 1978, p. 90;
*Spencer 1982)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): None (NIOSH/OSHA 1978, p. 90)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Water, foam, dry chemical, carbon dioxide
(-CHRIS 1980)
Special Fire Fighting Procedures: Keep unnecessary people away;
isolate hazard area. Stay upwind and keep out of low areas. Wear
self-contained breathing apparatus and full protective clothing. Move
container from fire area if you can do so without risk (DOT 1984, Guide
53).
Unusual Fire and Explosion Hazards: It is explosive and is usually
moistened with up to 10 percent water to reduce the hazard (*Spencer 1982)
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 534-52-1
Page 3 of 3
DINITROCRESOL
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (ACGIH 1980, p. 152)
Skin: Yes (*Gosselin 1976)
Ingestion: Yes (*Gosselin 1976)
Health Hazards (Acute, Delayed, and Chronic): Extremely toxic
material; probable oral lethal dose is 5-50 mg/kg in humans or between 7
drops and 1 teaspoonful for a 70 kg (150 Ib.) person (*Gosselin 1976).
Signs and Symptoms of Exposure: Symptoms of acute poisoning include
nausea, gastric upset, restlessness, sensation of heat, flushed skin,
sweating, rapid respiration and heart beat, fever, blue coloration of
skin, collapse, and coma (*Doull 1980). Chief symptoms after inhalation
were reported to include fever, rapid pulse and respiration, shortness of
breath, and cough (ACGIH 1980, p. 152). Chronic exposure may produce
fatigue, restlessness, anxiety, sweating, and thirst (*Doull 1980).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air and call
emergency medical care. Remove and isolate contaminated clothing and
shoes at the site. Immediately flush skin or eyes with running water for
at least 15 minutes if contact with material occurs (DOT 1984, Guide 53).
Wash contaminated skin and hair promptly with soap and water, or with
water alone if soap is not available; flush chemical from eyes with
copious amounts of clean water; in systemic poisoning reduce elevated body
temperature by physical means; administer sponge baths and cover victim
with light blankets. Administer oxygen to minimize tissue anoxia (^Morgan
1982).
SECTION VI -- USE INFORMATION
4,6-Dinitro-o-cresol is used as a spray to kill insect eggs on fruit
trees, as an herbicide, and as an insecticide (Hawley 1981, p. 374).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material; stop leak if it can be done without risk.
Take up small spills with sand or other noncombustible absorbent material;
place into containers for later disposal. Small dry spills may be
shoveled into clean, dry containers and covered. Larger spills should be
diked for later disposal (DOT 1984, Guide 53). Respiratory protective
equipment, hand protection, and eye protection should be used when
handling this material. Clothing and equipment should be cleaned after
use (*Encyc Occupat Health and Safety 1971).
-------
CAS Registry Number: 535-89-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CRIMIDINE
CAS Registry Number: 535-89-7
Synonyms: Pyrimidine, 2-Chloro-4-(Dimethylamino)-6-Methyl-; 2-Chloro-4-
Dimethylamino-6-Methyl-Pyrimidine; 2-Chloro-4-Methyl-6-Dimethylaminopyrimidine;
2-Chloro-N,N-6-Trimethyl-4-Pyrimidinamine; 4-Pyrimidinamine, 2-Chloro-N,N,6-
trimethyl-; Castrix; W 491
Chemical Formula: C H N.C1
Molecular Weight: 171.65
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LDc0 oral (mouse)
1.2 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 284-297°F, 140-147°C at 4 mmHg (*Weast 1974)
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Less than 10" at 20°C (^Hartley 1983)
Melting Point: 189°F, 87°C (*Weast 1974)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.936 g/100 mL at 20°C (^Hartley 1983)
Appearance and Odor: Brown waxy solid (*Weast 1974); colorless
crystals (-Hartley 1983)
-------
CAS Registry Number: 535-89-7
Page 2 of 3
CRIMIDINE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Pesticide, Solid, n.o.s.)
Small fires: dry chemical, carbon dioxide, water spray, or foam. Large
fires:" water spray, fog, or foam (DOT 1984, Guide 53).
Special Fire Fighting Procedures: Wear self-contained breathing
apparatus for fumes (^Hartley 1983).
Unusual Fire and Explosion Hazards: It emits highly toxic fumes when
heated to decomposition (*Sax 1975).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes, very stable in neutral medium (^Hartley 1983)
Conditions to Avoid: Decomposing heat (*Sax 1975)
Incompatibility (Materials to Avoid): Acids and acid fumes (*Sax 1975)
Hazardous Decomposition or Byproducts: It emits highly toxic chloride
fumes when heated to decomposition ("Sax 1975)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (*Gosselin 1984)
Health Hazards (Acute, Delayed, and Chronic): Super toxic; probable
oral lethal dose in humans is less than 5 mg/kg or less than 7 drops for a
70 kg (150 Ib.) person ("Gosselin 1984). May cause serious central
nervous system damage leading to convulsions (*Merck 1983).
-------
CAS Registry Number: 535-89-7
Page 3 of 3
CRIMIDINE
SECTION V -- HEALTH HAZARD DATA (Continued)
Signs and Symptoms of Exposure: Exposure may result in serious central
nervous system damage leading to convulsions that may be fatal (*Merck
1976). Symptoms include restlessness; apprehension; muscular stiffness;
sensitivity to light, noises, and contact; and cold sweat. If patient
survives 5 to 6 hours there may not be serious problems ("Gosselin 1984).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Pesticide, Solid,
n.o.s.) Move victim to fresh air; call emergency medical care. Remove
and isolate contaminated clothing and shoes at the site. In case of
contact with material, immediately flush skin or eyes with running water
for at least 15 minutes (DOT 1984, Guide 53).
SECTION VI -- USE INFORMATION
It is used as a rodenticide ("vMerck 1983). Not registered as a pesticide
in the U.S. (USEPA/Pesticide Index 1985).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Use organic vapor respiratory protection ("Hartley 1983). (Non-Specific
-- Pesticide, Solid, n.o.s.) Keep unnecessary people away; isolate hazard
area and deny entry. Stay upwind; keep out of low areas. Wear
self-contained (positive pressure if available) breathing apparatus and
full protective clothing. Do not touch spilled material; stop leak if you
can do so without risk. Small spills: absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. Small dry spills: with clean shovel place material into clean,
dry container and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal. If water pollution occurs,
notify appropriate authorities (DOT 1984, Guide 53).
-------
CAS Registry Number: 538-07-8
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ETHYLBIS(2-CHLOROETHYL)AMINE
CAS Registry Number: 538-07-8
Synonyms (NIOSH/RTECS 1983 Synonyms, Volume 3, p. 818): Triethylamine,
2,2'-Dichloro-; bis(2-Chloroethyl)Ethylamine; Ethylbis(beta-Chloroethyl)Amine;
Ethyl-S; HN1; TL 329
(U.S. Army 1975 Synonyms, p. 3-9): Nitrogen Mustard; HN-1
Chemical Formula: C,,H,,C10N
o 1 j 2.
Molecular Weight: 170.10
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD, dermal (dog)
40 mg/kg (-^NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 185°F, 85°C at 12 mmHg (Merck 1983, p. 683)
Specific Gravity (H20=l): 1.0861 at 23°C/4°C (Merck 1983, p. 683)
Vapor Pressure (mmHg): 0.24 at 25°C (U.S. Army 1975, p. 3-9)
Melting Point: -29°F, -34°C (Merck 1983, p. 683)
Vapor Density (AIR=1): 5.9 (U.S. Army 1975, p. 3-9)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Practically insoluble (Merck 1983, p. 683)
Appearance and Odor: Liquid with a faint, fishy amine odor (Merck
1983, p. 683).
-------
CAS Registry Number: 538-07-8
Page 2 of 4
ETHYLBIS(2-CHLOROETHYL)AMINE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): High enough not to interfere with military
use of the agent (U.S. Army 1975, p. 3-9).
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of nitrogen oxides and chlorides (Sax 1984, p. 458)
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (U.S. Army 1975, p. 3-9)
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of nitrogen oxides and chlorine (Sax 1984, p.
458).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Polymerizes slowly (U.S. Army 1975, p.
3-10). (Hazard not specified.)
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 458)
Skin: Yes (Sax 1984, p. 458)
Ingestion: Yes (Sax 1984, p. 458)
-------
CAS Registry Number: 538-07-8
Page 3 of 4
ETHYLBIS(2-CHLOROETHYL)AMINE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): This compound is a
nitrogen mustard. It is highly irritating to skin, eyes, and mucous
membranes (Merck 1983, p. 683). Nitrogen mustards have preferential
toxicity for rapidly dividing cells. Workers exposed briefly to estimated
concentrations of 10-100 ppm by inhalation became severely ill (Encyc
Occupat Health and Safety 1983, p. 462). The median lethal dosage is
1,500 mg/minute/m3 (U.S. Army 1975, p. 3-9).
Signs and Symptoms of Exposure: Irritates the eyes in quantities which
do not significantly damage the skin or respiratory tract, insofar as
single exposures are concerned. After mild vapor exposure, there may be
no skin lesions. After severe vapor exposures, or after exposure to the
liquid, erythema may appear. Irritation and itching may occur. Later,
blisters may appear in the erythematous areas. Effects on the respiratory
tract include irritation of the nose and throat, hoarseness progressing to
loss of voice, and a persistent cough. Fever, labored respiration, and
moist rales develop. Bronchial pneumonia may appear after the first 24
hours. Following ingestion or systemic absorption, material causes
inhibition of cell mitosis, resulting in depression of the blood-forming
mechanism and injury to other tissues. Severe diarrhea, which may be
hemorrhagic, occurs. Lesions are most marked in the small intestine and
consist of degenerative changes and necrosis in the mucous membranes.
Ingestion of 2 to 6 milligrams causes nausea and vomiting (U.S. Army 1975,
p. 3-9).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Nitrogen
Mustards) Stop exposure and treat symptomatically (Gilman 1985, p.
1257). (Non-Specific -- Poisonous Liquid, n.o.s.) Move victim to fresh
air; call emergency medical pare. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. In case of contact
with material, immediately flush skin or eyes with running water for at
least 15 minutes. Speed in removing material from skin is of extreme
importance. Remove and isolate contaminated clothing and shoes at the
site. Keep victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Delayed-action, military casualty agent (U.S. Army 1975, p. 3-10)
-------
CAS Registry Number: 538-07-8
Page 4 of 4
ETHYLBIS(2-CHLOROETHYL)AMINE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact; wear proper respiratory protection and
protective clothing (see Section V above). (Non-Specific -- Poisonous
Liquid, n.o.s.) Do not touch spilled material; stop leak if you can do so
without risk. Use water spray to reduce vapors. Small spills: absorb
with sand or other noncombustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
COMMENTS:
Sources searched but no information found:
Weast 1979
Hawley 1981
-------
CAS Registry Number: 541-25-3
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- LEWISITE
CAS Registry Number: 541-25-3
Synonyms: Arsine, Dichloro(2-Chlorovinyl)-; Arsine, (2-Chlorovinyl)
Dichloro-; Arsonous Bichloride, (2-Chloroethenyl)- (90); Chlorovinylarsine
Bichloride; beta-Chlorovinylbichloroarsine; 2-Chlorovinyldichloroarsine;
Dichloro(2-Chlorovinyl)Arsine
Chemical Formula: C H AsCl
Molecular Weight: 207.31
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 500 ug/m3 as arsenic (NIOSH/RTECS 1982, p. 442)
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC1 inhalation
(human) 0.051 mg/liter/30 minutes (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 374°F, 190°C (decomposes) (Merck 1983, p. 445)
{2
Specific Gravity (H,0=l): 1.888 at 20°C/4°C (Merck 1983, p. 445)
Vapor Pressure (mmHg): 0.395 at 20°C (Merck 1983, p. 445)
Melting Point: 32°F, 0.1°C (Merck 1983, p. 445)
Vapor Density (AIR=1): 7.1 (U.S. Army 1975, pp. 3-11, 3-12)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (Merck 1983, p. 445)
Appearance and Odor: Liquid with odor of geraniums (Merck 1983, p.
445).
-------
CAS Registry Number: 541-25-3
Page 2 of 4
LEWISITE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): None (U.S. Army 1975, pp. 3-11, 3-12)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Arsenic Compound, Liquid,
n.o.s.) Extinguish with dry chemical, carbon dioxide, water spray, or
foam. Use water spray, fog, or foam for large fires (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Arsenic Compound,
Liquid, n.o.s.) Wear special protective clothing and positive pressure
breathing apparatus (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: (Non-Specific -- Arsenic Compound,
Liquid, n.o.s.) Container may explode in heat of fire. Fire may produce
irritating and poisonous gases (DOT 1984, Guide 55).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Hydrolyzed by alkalies;
neutralized by sodium hypochlorite (Merck 1983, p. 445).
Hazardous Decomposition or Byproducts: Not Found
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 783)
Skin: Yes (Sax 1984, p. 783)
Ingestion: Yes (Sax 1984, p. 783)
-------
CAS Registry Number: 541-25-3
Page 3 of 4
LEWISITE
SECTION V -- HEALTH HAZARD DATA (Continued)
Heaith Hazards (Acute, Delayed, and Chronic): Highly toxic by all
routes of exposure, lethal dose in humans is 6 ppm (inhalation), 20 mg/kg
(.skin) (Sax 1984, p. 783). Eye injury below 300 mg-min./m3. It is a
blister agent, cell irritant, and systemic poison (U.S. Army 1975, pp.
3-11, 3-12).
Signs and Symptoms of Exposure: This material causes pulmonary edema,
diarrhea, restlessness, weakness, subnormal temperature and low blood
pressure. It produces an immediate searing sensation in the eye, and
permanent loss of sight if not decontaminated within 1 minute. It
produces an immediate and strong stinging sensation to the skin, followed
by reddening within 30 minutes and blistering after about 13 hours.
Inhalation of high concentrations may be fatal in as short a time as 10
minutes (U.S. Army 1975, pp. 3-11, 3-12).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Arsenic Compound,
Liquid, n.o.s.) Move victim to fresh air; call emergency medical care.
If not breathing, give artificial respiration. If breathing is difficult,
give oxygen. Remove and isolate contaminated clothing and shoes at the
site. In case of contact with material, immediately flush skin or eyes
with running water for at least 15 minutes. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation. Speed in removing material from skin is of extreme
importance (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Vesicant war gas; chemical warfare agent (Doull 1980, p. 279).
-------
CAS Registry Number: 541-25-3
Page 4 of 4
LEWISITE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid contact with eyes and skin; avoid breathing vapors (see Section V
above). (Non-Specific -- Arsenic Compound, Liquid, n.o.s.) Keep
unnecessary people away; isolate hazard area and deny entry. Stay upwind;
keep out of low areas. Ventilate closed spaces before entering them.
Wear positive pressure breathing apparatus and special protective
clothing. Remove and isolate contaminated clothing at the site. Do not
touch spilled material; stop leak if you can do so without risk. Use
water spray to reduce vapors. Small spills: absorb with sand or other
noncombustible absorbent material and place into containers for later
disposal. Large spills: dike far ahead of spill for later disposal (DOT
1984, Guide 55). Can be decontaminated by supertropical bleach, DS2, or
caustic soda (U.S. Army 1975, pp. 3-11, 3-12).
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CAS Registry Number: 541-53-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:.
CHEMICAL IDENTITY -- DITHIOBIURET
CAS Registry Number: 541-53-7
Synonyms: Biuret, 2,4-Dithio-; Imidodicarbonimidothioic Diaraide;
Imidodicarbonodithioic Diamide; Thioimidodicarbonic Diamide; DTB; Urea,
2-thio-l-(thiocarbamoyl)-
Chemical Formula: C H N S-
Molecular Weight: 135.22
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDL.H: Not Found
Other Limits Recommended: Toxicity information: ID oral (rat) 5
mg/kg ("NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): 1.522 at 30°C (Merck 1983, p. 493)
Vapor Pressure (mraHg): Not Found
Melting Point: 358°F, 181°C (decomposes) (Merck 1983, p. 493)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: 0.27 g/100 mL at 27°C (Merck 1983, p. 493)
Appearance and Odor: Crystalline solid (Merck 1983, p. 493); odor not
found
-------
CAS Registry Number: 541-53-7
Page 2 of 3
DITHIOBIURET
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Dithiocarbamate Pesticide,
Solid, n.o.s.) Extinguish fire using agent suitable for type of
surrounding fire. (Material itself does not burn or burns with
difficulty.) Use water in flooding quantities as fog. Use alcohol foam,
carbon dioxide or dry chemical (Student 1981, p. 213).
Special Fire Fighting Procedures: (Non-Specific -- Dithiocarbamate
Pesticide, Solid, n.o.s.) Wear boots, protective gloves, goggles and
self-contained breathing apparatus (Student 1981, p. 213).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits highly toxic fumes of oxides of sulfur and nitrogen (Sax 1984, p.
1257).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: Sulfur oxides and nitrogen
oxides are formed when the material is heated to decomposition (Sax 1984,
p. 1257).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1257)
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 1257)
-------
CAS Registry Number: 541-53-7
Page 3 of 3
DITHIOBIURET
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): The material is highly
toxic. It may cause respiratory failure (Merck 1983, p. 493).
Signs and Symptoms of Exposure: Symptoms include respiratory paralysis
(Merck 1983, p. 493).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Dithiocarbamate
Pesticide, n.o.s.) Move victim to fresh air; call emergency medical
care. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed; keep victim
under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
This material is used as a plasticizer, as a rubber accelerator, and as an
intermediate in manufacturing of pesticides (Merck 1983, p. 493).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Dithiocarbamate Pesticide, Solid, n.o.s.) Keep sparks,
flames and other sources of ignition away. Keep material out of water
sources and sewers. Avoid breathing dusts and fumes from burning
material. Keep upwind; avoid bodily contact with the material. Wear
boots, protective gloves, and goggles. Do not handle broken packages
without protective equipment. Wash away any material which may have
contacted the body with copious amounts of water or soap and water. Wear
self-contained breathing apparatus. If contact with material is
anticipated wear full protective clothing (Student 1981, p. 213).
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CAS Registry Number: 542-76-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PROPIONITRILE, 3-CHLORO-
CAS Registry Number: 542-76-7
Synonyms: 3-Chloropropanonitrile; l-Chloro-2-Cyanoethane;
3-Chloropropanenitrile; 3-Chloropropionitrile; beta-Chloropropionitrile;
Propanenitrile, 3-Chloro-; USAF A-8798
Chemical Formula: C.H.C1N
3 4
Molecular Weight: 89.53
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD
-------
CAS Registry Number: 542-76-7
Page 2 of 3
PROPIONITRILE, 3-CHLORO-
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 168°F (CC) (*Hawley 1977; Sax 1984, p. 769)
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: Alcohol foam is recommended, but water spray
can be used because the material can be cooled below its flash point (NFPA
1984, p. 325M-26).
Special Fire Fighting Procedures: (Non-Specific -- Propionitrile)
Wear positive pressure breathing apparatus and special protective
clothing. Isolate for 1/2 mile in all directions if tank car or truck is
involved in fire (DOT 1984, Guide 28).
Unusual Fire and Explosion Hazards: Toxic gas (hydrogen chloride) is
released when the compound is heated above 130°C (266°F) (*Merck 1976).
When heated to decomposition, it emits very toxic fumes of chlorine-
containing compounds and nitrogen oxides (Sax 1984, p. 769).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Heat (-Merck 1976).
Hazardous Decomposition or Byproducts: Hydrogen chloride is a
by-product (*Merck 1976). Also, when heated to decomposition, it emits
very toxic fumes of chlorine-containing compounds and nitrogen oxides (Sax
1984, p. 769).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Hawley 1977)
Skin: Yes (*Hawley 1977)
Ingestion: Yes (*Hawley 1977)
-------
CAS Registry Number: 542-76-7
Page 3 of 3
PROPIONITRILE, 3-CHLORO-
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Toxic effects are a
result of systemic cyanide poisoning (*Merck 1976). (Non-Specific --
Cyanide) Few poisons are more rapidly lethal. Average oral lethal dose
for hydrogen cyanide is approximately 60-90 mg (corresponds to 200 mg of
potassium cyanide). Cause of death is lack of oxygen to the body's cells
(especially the brain and heart) as a result of the chemical inhibiting
cell enzymes (Gosselin 1984, pp. III-124-125).
Signs and Symptoms of Exposure: (Non-Specific -- Cyanide) Symptoms
include rapid and irregular breathing, anxiety, confusion, odor of bitter
almonds (on breath or vomitus), nausea, vomiting (if oral exposure),
irregular heart beat, a feeling of tightness in the chest, bright pink
coloration of the skin, sweating, protruding eyeballs, dilated pupils,
unconsciousness followed by convulsions, involuntary urination and
defecation, paralysis and respiratory arrest (heart will beat after
breathing stops) (Gosselin 1984, p. III-126-127).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Cyanide) Get
emergency medical treatment immediately. If victim has taken the
substance by ingestion (orally) and is not showing symptoms, give syrup of
ipecac. If there is exposure through skin contact, wash immediately with
soap and water. If severe skin contact, treat patient for oral or
inhalation exposure. Exposed eyes should be flushed copiously with water
for at least 15 minutes. If the victim stops breathing before emergency
medical treatment is available, give artificial respiration or oxygen, but
avoid mouth to mouth respiration; also avoid contact with contaminated
skin (Gosselin 1984, p. III-127; *Rumack 1975 to Present).
SECTION VI -- USE INFORMATION
Used in pharmaceutical and polymer synthesis (*Merck 1976).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Propionitrile) Do not touch spilled material; stop leak
if you can do so without risk. Use water spray to reduce vapors. Absorb
small spills with sand or other noncombustible absorbent material. Dike
far ahead of spill for later disposal. Isolate hazard area and deny
entry. Stay upwind. Wear positive pressure breathing apparatus and
special protective clothing (DOT 1984, Guide 28).
-------
CAS Registry Number: 542-88-1
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- CHLOROMETHYL ETHER
CAS Registry Number: 542-88-1
Synonyms-: Bis(Chloromethyl) Ether; 1,1' -Dichlorodimethyl Ether;
alpha,alpha'-Dichlorodimethyl Ether; BCME; bis-CME; Chloro(chloromethoxy)
Methane; Dichlorinated Methyl Oxide; Dichlorodimethyl Ether; Dichloromethyl
Ether; Dimethyl-1,1'-Dichloroether; Ether, bis(Chloromethyl); Monochloromethyl
Ether; Oxybis(Chloromethane); Sym-Dichloro-Dimethyl Ether; Sym-Dichloromethyl
Ether; Methane, Oxybis(chloro-
Chemical Formula: C0H.Cl.O
242
Molecular Weight: 114.97
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.001 ppm (0.005 mg/m3) (*ACGIH 1980)
IDLH: Not Found
Other Limits Recommended: Human carcinogen -- recommended TLV 0.001
ppm (ACGIH 1984, p. 40). Toxicity information: LC.. inhalation (man)
0.469 mg/liter/3 hours (*NIOSH/RTECS 1985).
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 223°F, 106°C (-Merck 1976)
Specific Gravity (H 0=1): 1.315 at 20°C (-Merck 1976)
Vapor Pressure (mmHg): 30 at 22°C (-Callahan 1979)
Melting Point: -42.7°F, -41.5°C (*Weast 1979)
Vapor Density (AIR=1): 4.0 (*Sax 1968)
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 542-88-1
Page 2 of 4
CHLOROMETHYL ETHER
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Not soluble; decomposes (Weast 1979, p. C-300)
Appearance and Odor: Colorless liquid ("Merck 1976) with extremely
suffocating odor (*Sittig, 1981).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Less than 19°C (-Bretherick 1979)
Flammable Limits:
LEL: Dangerously explosive (*Sax 1985)
UEL: Not Found
Extinguishing Methods: Small fires: dry chemical, carbon dioxide,
water spray, or foam. Large fires: water spray, fog, or foam (*DOT 1984)
Special Fire Fighting Procedures: Move container from fire area if you
can do so without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material ('"DOT 1984).
Unusual Fire and Explosion Hazards: This material may burn but will
not ignite easily. Container may explode in heat of fire (*DOT 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Merck 1976)
Stable:
Conditions to Avoid: Avoid decomposing heat (Sax 1985, p. 63);
powerful oxidizers areas, of high fire hazard (*Sax 1975) and moist
air (*Merck 1976).
Incompatibility (Materials to Avoid): Water: hydrolyzes very rapidly
(half life 10-40 seconds) on contact with water ("Callahan 1979).
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of chlorides (Sax 1985, p. 463). Decomposed by
water to hydrochloric acid and formaldehyde ("Merck 1976) .
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 542-88-1
Page 3 of 4
CHLOROMETHYL ETHER
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1985, p. 463)
Skin: Yes (Sax 1985, p. 463)
Ingestion: Yes (Sax 1985, p. 463)
Health Hazards (Acute, Delayed, and Chronic): Acute toxicity is high
by ingestion, inhalation, and skin irritation. Small quantities may cause
death or permanent injury after very short exposure (*Sax 1968).
Chloromethyl ether is an alkylating agent which is a recognized human
carcinogen. There is a strong association between industrial exposure and
excess lung cancer (*Sittig 1981; -NIOSH 1984; *IARC 1972-85).
Signs and Symptoms of Exposure: Vapor is severly irritating to the
skin and mucous membranes and may cause cornea damage which may heal
slowly ("Sittig 1981).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal .body temperature. Effects may be
delayed. Keep victim under observation ("DOT 1984).
SECTION VI -- USE INFORMATION
Used as a research chemical and lab reagent (*Hawley 1977; ""SRI). Not
used commercially in the U.S. (*SRI), but was formerly used for
chloromethylation in industry (*ACGIH 1980). Has been used as an
alkylating agent in the manufacture of polymers (*Sittig 1981).
-------
CAS Registry Number: 542-88-1
Page 4 of 4
CHLOROMETHYL ETHER
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Full body protective clothing and gloves should be used on entering areas
of potential exposure. Those employed in handling operations should be
provided with full-face, supplied air respirators of continuous flow or
pressure demand type (*Sittig 1981). Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing. Remove and isolate
contaminated clothing at the site. Spill or leak: do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Small spills: absorb with sand or other noncombustible
absorbent material and place into containers for later disposal. Large
spills: dike far ahead of spills for later disposal (*DOT 1984).
-------
CAS Registry Number: 542-90-5
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ETHYL THIOCYANATE
CAS Registry Number: 542-90-5
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 743) Thiocyanic
Acid, Ethyl Ester; Ethane, Thiocyanato-; Ethyl Rhodanate; Ethyl Sulfocyanate
Chemical Formula: C H NS
Molecular Weight: 87.15
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD.. oral (cat) 10
mg/kg ("NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 295°F, 146°C (Merck 1983, p. 1336)
Specific Gravity (H20=l): 1.007 at 23°C/4°C (Merck 1983, p. 1336)
Vapor Pressure (mmHg): Not Found
Melting Point: -122°F, -85.5°C (Weast 1983, p. C-515)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (Merck 1983, p. 1336)
Appearance and Odor: Liquid (Merck 1983, p. 1336).
-------
CAS Registry Number: 542-90-5
Page 2 of 4
ETHYL THIOCYANATE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Pesticide, Liquid, n.o.s.)
Small fires: dry chemical, carbon dioxide, water spray, or foam. Large
fires: water spray, fog, or foam (DOT 1984, Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Pesticide, Liquid,
n.o.s.) Keep unnecessary people away; isolate hazard area and deny
entry. Stay upwind; keep out of low areas. Ventilate closed spaces
before entering them. Wear positive pressure breathing apparatus and
special protective clothing. Move container from fire area if you can do
it without risk. Fight fire from maximum distance. Dike fire control
water for later disposal; do not scatter the material (DOT 1984, Guide 55)
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of oxides of nitrogen and sulfur (Sax 1984, p.
1394).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of oxides of nitrogen and sulfur (Sax 1984, p.
1394).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Sax 1984, p. 1394)
-------
CAS Registry Number: 542-90-5
Page 3 of 4
ETHYL THIOCYANATE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic if ingested (Sax 1984, p. 1394).
Signs and Symptoms of Exposure: Toxicity hazard similar to thiocyanate
(Sax 1984, p. 1394). Prolonged absorption may produce various skin
eruptions, runny nose, and occasionally dizziness, cramps, nausea,
vomiting and mild or severe disturbances of the nervous system (Sax 1984,
p. 2568). Ethyl thiocyanate is an aliphatic thiocyanate (Gosselin 1981,
p. 11-288). Aliphatic thiocyanates have the following signs and
symptoms. The ingestion of a concentrated solution may lead to vomiting.
The principal systemic reaction is probably one of central nervous
depression, interrupted by periods of restlessness, abnormally fast and
deep respiratory movements and convulsions. Death is usually due to
respiratory arrest from paralysis of the medullary centers. In nonfatal
cases injuries to the liver and kidneys may appear (Gosselin 1981, p.
111-16).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Treatment is as for aliphatic
thiocyanates (Gosselin 1981, p. 11-288). Because cyanide is probably
largely responsible for poisonings, antidotal measures against cyanide
should be instituted promptly (Gosselin 1981, p. 111-16). First aid for
cyanide includes moving the victim to fresh air. Call emergency medical
care. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact with material, immediately
flush skin or eyes with running water for at least 15 minutes. Speed in
removing material from skin is of extreme importance. Remove and isolate
contaminated clothing and shoes at the site. Keep victim quiet and
maintain normal body temperature. Effects may be delayed, keep victim
under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
It is an agricultural insecticide (Gosselin 1981, p. 11-288).
-------
CAS Registry Number: 542-90-5
Page 4 of 4
ETHYL THIOCYANATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Pesticide, Liquid, n.o.s.) Do not touch spilled
material; stop leak if you can do so without risk. Use water spray to
reduce vapors. Fox small spills, absorb with sand or other noncorabustible
absorbent material and place into containers for later disposal. For
large spills, dike far ahead of spill for later disposal. Wear
self-contained breathing apparatus and full protective clothing (DOT 1984,
Guide 55).
COMMENTS
Sources searched but no information found:
Hayes 1982
NFPA 1984
Farm Chemicals Handbook 1984
Buchel 1983
Hawley 1981
DASE 1980
Verschueren 1983
-------
CAS Registry Number: 555-77-1
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- TRIS(2-CHLOROETHYL)AMINE
CAS Registry Number: 555-77-1
Synonyms: (SANSS 1983 SYNONYMS) Triethylamine, 2,2',2"-Trichloro-;
Trichlormethine; Tri-(2-Chloroethyl)Amine; 2,2',2"-Trichlorotriethylamine;
Tris(beta-chloroethyl)amine; TS 160; Ethanamine, 2-Chloro-N,N-bis
(2-Chloroethyl)-; HN 3; TL 145; 2-Chloro-N,N-bis(2-Chloroethyl)
Ethanamine
Chemical Formula: C-H^Cl-N
D lZ J
Molecular Weight: 204.54
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(mouse) 0.35 mg/liter/10 minutes (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 493°F, 256°C calculated, decomposes (U.S. Army 1975, p.
3-10)
Specific Gravity (H20=l): 1.2347 (Merck 1979, p. 1379)
Vapor Pressure (mmHg): 0.0109 at 25°C (U.S. Army 1975, p. 3-10)
Melting Point: 25°F, -4°C (Weast 1979, p. C-110)
Vapor Density (AIR=1): 7.1 (U.S. Army 1975, p. 3-10)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (Weast 1979, p. C-110)
-------
CAS Registry Number: 555-77-1
Page 2 of 4
TRIS(2-CHLOROETHYL)AMINE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Liquid with faint odor of fish and soap (Merck
1983, p. 1379); none when pure (U.S. Army 1975, p. 3-10)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): High enough not to interfere with military
use of the agent (U.S. Army 1975, p. 3-10).
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: Not Found
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (U.S. Army 1975, p. 3-10)
Conditions to Avoid: Decomposing heat (Sax 1984, p. 2691)
Incompatibility (Materials to Avoid): No action on metals or other
materials if material is kept dry (U.S. Army 1975, p. 3-10); otherwise, no
information found.
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits chloride and nitrogen oxides (Sax 1984, p. 2691).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 2691)
Skin: Yes (Sax 1984, p. 2691)
Ingestion: Yes (Sax 1984, p. 2691)
-------
CAS Registry Number: 555-77-1
Page 3 of 4
TRIS(2-CHLOROETHYL)AMINE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Most toxic of the
nitrogen mustards. The median lethal dose for inhalation is
1,500 mg-min/m3; for skin absorption (masked personnel) is
10,000 mg-min/m3. The medium incapacitating dose for eye injury is
200 mg-min/m3; for skin absorption is 2,500 mg-min/m3 (U.S. Army 1975,
p. 3-10).
Signs and Symptoms of Exposure: Irritates the eyes in quantities which
do not significantly damage the skin or respiratory tract, insofar as
single exposures are concerned. After mild vapor exposure, there may be
no skin lesions. After severe vapor exposures, or after exposure to the
liquid, erythema may appear. Irritation and itching may occur. Later,
blisters may appear in the erythematous areas. Effects on the respiratory
tract include irritation of the nose and throat, hoarseness progressing to
loss of voice, and a persistent cough. Fever, labored respiration, and
moist rales develop. Bronchial pneumonia may appear after the first 24
hours. Following ingestion or systemic absorption, material causes
inhibition of cell mitosis, resulting in depression of the blood-forming
mechanism and injury to other tissues. Severe diarrhea, which may be
hemorrhagic, occurs. Lesions are most marked in the small intestine and
consist of degenerative changes and necrosis in the mucous membranes.
Ingestion of 2 to 6 milligrams causes nausea and vomiting (U.S. Army 1975,
p. 3-11).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Nitrogen
Mustards) Stop exposure and treat symptomatically (Gilman 1985, p.
1257). (Non-Specific -- Poisonous Liquid, n.o.s.) Move victim to fresh
air; call emergency medical care. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. In case of contact
with material, immediately flush skin or eyes with running water for at
least 15 minutes. Speed in removing material from skin is of extreme
importance. Remove and isolate contaminated clothing and shoes at the
site. Keep victim quiet and maintain normal body temperature. Effects
may be delayed;, keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
Delayed-action casualty military agent (U.S. Army 1975, p. 3-10).
-------
CAS Registry Number: 555-77-1
Page 4 of 4
TRIS(2-CHLOROETHYL)AMINE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact (see Section V above). (Non-Specific --
Poisonous Liquid, n.o.s.) Do not touch spilled material; stop leak if you
can do so without risk. Use water spray to reduce vapors. Small spills:
absorb with sand or other noncombustible absorbent material and place into
containers for later disposal. Large spills: dike far ahead of spill for
later disposal (DOT 1984, Guide 55).
COMMENTS
Sources searched but no information found:
NFPA 1984
Hawley 1981
Student 1981
-------
CAS Registry Number: 556-61-6
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- METHYL ISOTHIOCYANATE
CAS Registry Number: 556-61-6
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 676) Methane,
Isothiocyahato-; Isothiocyanatomethane; Isothiocyanic Acid, Methyl Ester;
Methyl Mustard Oil; MIC; MIT; MITC; Morton EP-161E; Trapex; Trapexide; Vorlex;
Vortex; WN 12
Chemical Formula: C.H.NS
Molecular Weight: 73.12
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD. oral (woman)
low
1000 mg/kg; LD5Q dermal (rabbit) 33 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 246°F, 119°C (Sax 1984, p. 1866)
Specific Gravity (H20=l): 1.069 at 37°C/4°C (Weast 1983, p. C-376)
Vapor Pressure (mmHg): Not Found
Melting Point: 95-97°F, 35-36°C (Sax 1984, p. 1866)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
-------
CAS Registry Number: 556-61-6
Page 2 of 4
METHYL ISOTHIOCYANATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Solubility in Water: Slightly soluble (Sax 1984, p. 1866)
Appearance and Odor: Crystalline (Sax 1984, p. 1866)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Pesticide, Solid, n.o.s.)
Small fires: dry chemical, carbon dioxide, water spray, or foam. Large
fires: water spray, fog, or foam (DOT 1984, Guide 53).
Special Fire Fighting Procedures: (Non-Specific -- Pesticide, Solid,
n.o.s.) Move container from area if you can do so without risk. Wear
self-contained (positive pressure if available) breathing apparatus and
full protective clothing (DOT 1984, Guide 53).
Unusual Fire and Explosion Hazards: (Non-Specific -- Pesticide, Solid,
n.o.s.) This material may burn, but does not ignite readily. Fire may
produce irritating or poisonous gases (DOT 1984, Guide 53).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Do not store below -20°C or at elevated
temperatures. Keep away from sparks (Farm Chemicals Handbook 1984, p.
C-242).
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated it emits very
dangerous cyanides and sulfur compounds (Sax 1984, p. 1866).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 556-61-6
Page 3 of 4
METHYL ISOTHIOCYANATE
SEC! ION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Farm Chemicals Handbook 1984,
p. C-242)
Skin: Yes (Farm Chemicals Handbook 1984, p. C-242)
Ingestion: Yes (NIOSH/RTECS 1983, p. 676)
Health Hazards (Acute, Delayed, and Chronic): Very toxic; probable
human oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz.
for a 70 kg (150 Ib.) person (Gosselin 1984, p. 11-352). Highly
irritating to skin, mucous membrances, and eyes (Sax 1984, p. 1866).
Human oral minimum lethal dose: approximately 1 g/kg (NIOSH/RTECS 1983,
Volume 2, p. 676).
Signs and Symptoms of Exposure: Extreme irritation of eyes, mucous
membranes, and skin. Coughing and other symptoms of extreme pulmonary
irritation would be expected if vapors are inhaled (Sax 1984, p. 1866).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Pesticide, Solid,
n.o.s.) Move victim to fresh air; call emergency medical care. In case
of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Remove and isolate contaminated clothing
and shoes at the site (DOT 1984, Guide 53).
SECTION VI -- USE INFORMATION
It is used as a soil fumigant. A mixture of methyl isothiocyanate and
chlorinated C, hydrocarbons is used as a soil fumigant for control of
weeds, fungi, insects, and nematodes (Farm Chemicals Handbook 1984,
pp. C230, C242).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Protective clothing: common protective clothing such as rubber gloves and
boots may be penetrated by methyl isothiocyanate mixtures (Vorlex).
Polyethylene gloves and footwear are recommended. For short-term exposure
when small spills occur, during repair of equipment, transfer of liquid,
etc. use half-face respirator with chemical worker's goggles or full-face
respirators. Cartridges such as Willson R-21 are adequate for short-term
exposure. For large spills in poorly ventilated areas, use a
self-contained or air-supplied respirator (Farm Chemicals Handbook 1984,
p. C-242).
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CAS Registry Number: 556-61-6
Page 4 of 4
METHYL ISOTHIOCYANATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE (Continued)
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Pesticide, Solid, n.o.s.) Do not touch spilled material;
stop leak if you can do so without risk. Small spills: absorb with sand
or other noncombustible absorbent material and place into containers for
later disposal. Small dry spills: with clean shovel place material into
clean, dry container and cover; move containers from spill area. Large
spills: dike far ahead of spill for later disposal. Keep unnecessary
people away; isolate hazard area and deny entry. Stay upwind; keep out of
low areas. Wear self-contained (positive pressure if available) breathing
apparatus and full protective clothing (DOT 1984, Guide 53).
-------
CAS Registry Number: 556-64-9
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- METHYL THIOCYANATE
CAS Registry Number: 556-64-9
Synonyms: Thiocyanic Acid, Methyl Ester; Thiocyanatomethane; Methyl
Rhodanate; Methyl Sulfocyanate
Chemical Formula: C2H3NS
Molecular Weight: 73.12
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: ID, oral (cat)
8.5 mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 266-271°F, 130-133°C (Sax 1984, p. 1934)
Specific Gravity (H 0=1): 1.068 at 25°C/4°C (*Weast 1979)
Vapor Pressure (mmHg): Not Found
Melting Point: -60°F, -51°C (-Merck 1976)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Very slight (-Merck 1976)
Appearance and Odor: Colorless liquid, onion odor (*Merck 1976)
-------
CAS Registry Number: 556-64-9
Page 2 of 4
METHYL THIOCYANATE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: (Non-Specific -- Pesticide, Liquid, n.o.s.)
Small fires: dry chemical, carbon dioxide, water spray, or foam. Large
fires: water spray, fog, or foam. Move container from fire area if you
can do so without risk. Fight fire from maximum distance. Dike fire
control water for later disposal; do not scatter the material (DOT 1984,
Guide 55).
Special Fire Fighting Procedures: (Non-Specific -- Pesticide, Liquid,
n.o.s.) Keep unnecessary people away; isolate hazard area and deny
entry. Stay upwind; keep out of low areas. Ventilate closed spaces
before entering them. Wear positive pressure breathing apparatus and
special protective clothing. Remove and isolate contaminated clothing at
the site. If water pollution occurs, notify appropriate authorities (DOT
1984, Guide 55).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of oxides of nitrogen and sulfur (Sax 1984, p.
1934).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not. Found
Conditions to Avoid: This material is volatile (-Gosselin 1976)
Incompatibility (Materials to Avoid): (Non-Specific -- Thiocyanates)
Incompatible with nitric acid. Violent reactions have occurred when mixed
with chlorates, nitrates, nitric acid, organic peroxides, peroxides,
potassium chlorate, and sodium chlorate (Sax 1984, p. 2568).
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits very toxic fumes of oxides of nitrogen and sulfur (Sax 1984, p.
1934).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
-------
CAS Registry Number: 556-64^-9
Page 3 of 4
METHYL THIOCYANATE
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (-Rumack 1975 to Present)
Skin: Yes (-Gosselin 1976)
Ingestion: Yes (*Rumack 1975 to Present)
Health Hazards (Acute, Delayed, and Chronic): This material is highly
toxic if ingested (Sax 1984, p. 1934). It is a rapidly acting poison
(-Gosselin 1976).
Signs and Symptoms of Exposure: (Non-Specific -- Thiocyanates)
Prolonged absorption may produce various skin eruptions, runny nose, and
occasionally, dizziness, cramps, nausea, vomiting and mild or severe
disturbances of the nervous system (Sax 1984, p. 2568). (Non-Specific --
Aliphatic Thiocyanates) The ingestion of a concentrated solution may lead
to vomiting. The principal systemic reaction is probably one of central
nervous system depression, interrupted by periods of restlessness,
abnormally fast and deep respiratory movements and convulsions. Death is
usually due to respiratory arrest from paralysis of the medullary
centers. In nonfatal cases injuries to the liver and kidneys may appear
(Gosselin 1981, p. 111-16).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Aliphatic
Thiocyanates) Because cyanide is probably largely responsible for
poisonings, antidotal measures against cyanide should be instituted
promptly (Gosselin 1981, p. 111-16). (Non-Specific -- Cyanide Solution)
Move victim to fresh air; call emergency medical care. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen. In
case of contact with material, immediately flush skin or eyes with running
water for at least 15 minutes. Speed in removing material from skin is of
extreme importance. Remove and isolate contaminated clothing and shoes at
the site. Keep victim quiet and maintain normal body temperature.
Effects may be delayed, keep victim under observation (DOT 1984, Guide 55).
SECTION VI -- USE INFORMATION
It is used as an agricultural insecticide, a fumigant ("Gosselin 1976),
and as a research chemical. No evidence of commercial production in the
U.S. (*SRI).
-------
CAS Registry Number: 556-64-9
Page 4 of 4
METHYL THIOCYANATE
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation and skin contact. Wear proper protective clothing and
respiratory protection (see Section V above). (Non-Specific -- Pesticide,
Liquid, n.o.s.) Do not touch spilled material; stop leak if you can do so
without risk. Use water spray to reduce vapors. For small spills, absorb
with sand or other noncombustible absorbent material and place into
containers for later disposal. For large spills, dike far ahead of spill
for later disposal (DOT 1984, Guide 55).
-------
CAS Registry Number: 558-25-8
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- METHANESULFONYL FLUORIDE
CAS Registry Number: 558-25-8
Synonyms: (NIOSH/RTECS 1983 Synonyms, Volume 2, p. 684) Fumette;
Methanesulphonyl Fluoride; MSF
Chemical Formula. CH FO S
Molecular Weight: 98.10
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LC. inhalation
(rat) 0.14 mg/liter (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H 0=1): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: Not Found
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Not Found
Appearance and Odor: Not Found
-------
CAS Registry Number: 558-25-8
Page 2 of 3
METHANESULFONYL FLUORIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: Not Found
Special Fire Fighting Procedures: Not Found
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of fluorides and sulfur oxides (Sax 1984, p. 1764),
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of fluorides and sulfur oxides (Sax 1984, p.
1764).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (Sax 1984, p. 1764)
Skin: Not Found
Ingestion: Not Found
Health Hazards (Acute, Delayed, and Chronic): Highly toxic when
inhaled (Sax 1984, p. 1764).
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Not Found
-------
CAS Registry Number: 558-25-8
Page 3 of 3
METHANESULFONYL FLUORIDE
SECTION VI -- USE INFORMATION
Not Found
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid inhalation. Wear proper respiratory protection (see Section V
above).
COMMENTS
Sources searched but no information found:
Weast 1979
DOT 1984
ACGIH 1984
NIOSH/OSHA 1978
Weiss 1980
Merck 1983
Buchel 1983
Encyc Occupat Health and Safety 1983
Farm Chemicals Handbook 1984
Hawley 1981
Clayton and Clayton 1981-82
Verschueren 1983
Student 1981
NFPA 1984
Gosselin 1984
-------
CAS Registry Number: 563-12-2
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- ETHION
CAS Registry Number: 563-12-2
Synonyms: Phosphorodithioic Acid, S,S*-Methylene 0,0,0',0*-Tetraethyl
Ester; AC 3422; Bis(S-(Diethoxyphosphinothioyl)Mercapto)Methane; Bladan;
Diethion; Embathion; ENT 24,105; Ethanox; Ethiol; Ethiol 100; Ethodan;
Ethopaz; Ethyl Methylene Phosphorodithioate; FMC-1240; Fosfatox E; Fosfono 50;
Hylemax; Hylemox; Itopaz; KWIT; NIA 1240; Niagara 1240; Nialate; 0,0,0',0'-
Tetraethyl S,S'-Methylene Di(Phosphorodithioate); 0,0,0',0'-Tetraethyl S,S*-
Methylenebisphosphordithioate; 0,0,0*,0*-Tetraethyl S,S'-Methylenebisphos-
phorodithioate; 0,0,0,0-Tetraethyl S,S*-Methylenebis (Dithiophosphate);
Phosphorodithioic Acid, 0,0-Diethyl Ester, S,S-Diester with Methanedithiol;
Phosphorodithioic Acid, S,S*-Methylene 0,0,0',0'-Tetraethyl Ester;
Phosphotox E; Rhodiacide; Rhodocide; Rodocid; Rodocide; RP 8167;
S,S*-Methylene 0,0,0*,0*-Tetraethyl Phosphorodithioate; Soprathion; Tetraethyl
S,S*-Methylene Bis(Phosphorothiolothionate); Vegfru Fosmite
Chemical Formula: C0H-0O.P0S.
9 22 4 2 4
Molecular Weight: 384.48
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: TWA 0.4 mg/m3 (skin) (*ACGIH 1984)
IDLH: Not Found
Other Limits Recommended: Toxicity information: LD5Q oral (rat) 13
mg/kg (*NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): 1.215-1.230 at 20°C/4°C (^Worthing 1979)
Vapor Pressure (mmHg): l.Sxlo"6 at 77°F, 25°C (^Worthing 1979)
Melting Point: 9-10°F, -12 - -13°C (*Merck 1983)
-------
CAS Registry Number: 563-12-2
Page 2 of 4
ETHION
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Slightly soluble (*Merck 1983)
Appearance and Odor: Colorless to amber-colored liquid (*Worthing
1979)°; odorless (*Farm Chemicals Handbook 1984) or very disagreeable odor
(*ACGIH 1980)
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits: Does not ignite easily (-DOT 1984)
LEL: Not Found
UEL: Not Found
Extinguishing Methods: For small fires, use dry chemical, carbon
dioxide, water spray, or foam. For large fires, use water spray, fog, or
foam (*DOT 1984).
Special Fire Fighting Procedures: Move containers from fire area if it
can be done without risk. Dike fire control water for later disposal, do
not scatter the material. Fight fire from maximum distance. Wear
positive pressure breathing apparatus and protective clothing (*DOT 1984).
Unusual Fire and Explosion Hazards: Shock can shatter the container,
releasing the contents (*Sax 1979). Fire may produce irritating or
poisonous gases (*DOT 1984).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Yes (*Worthing 1979)
Stable:
Conditions to Avoid: Slowly oxidized in air (^Worthing 1979)
Incompatibility (Materials to Avoid): Hydrolyzed by acids and alkalies
(^Worthing 1979)
Hazardous Decomposition or Byproducts: Decomposes above 302°F, 150°C
(^Sunshine 1969). When heated to decomposition it emits highly toxic
fumes of oxides of sulfur and phosphorus (Sax 1984, p. 1372).
-------
CAS Registry Number: 563-12-2
Page 3 of 4
ETHION
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*DOT 1984)
Skin: Yes (*DOT 1984)
Ingestion: Yes (*DOT 1984)
Health Hazards (Acute, Delayed, and Chronic): This material is very
toxic; the probable oral lethal dose for humans is 50-500 rag/kg, which is
between one teaspoonful and one ounce for a 150-lb person (*Gosse'lin 1976).
Signs and Symptoms of Exposure: Symptoms may include nausea, vomiting,
abdominal cramps, diarrhea, excessive salivation, headache, giddiness,
weakness, muscle twitching, difficult breathing, blurring or dimness of
vision, and loss of muscle coordination. Death may occur from failure of
the respiratory center, paralysis of the respiratory muscles, intense
bronchoconstriction, or all three (*Gosselin 1976).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin and eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (*DOT 1984).
SECTION VI -- USE INFORMATION
Insecticide and acaricide for citrus fruit, apples, nuts, other fruit, and
cotton (*SRI).
-------
CAS Registry Number: 563-12-2
Page 4 of 4
ETHION
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Avoid breathing vapors. Wear proper respiratory protection and protective
clothing (see Section V above). Do not touch spilled material. Use water
spray to reduce vapors. Take up small spills with sand or other
noncombustible absorbent material. Large spills should be diked far ahead
of the spill for later disposal (*DOT 1984).
-------
CAS Registry Number: 563-41-7
Page 1 of 3
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- SEMICARBAZIDE HYDROCHLORIDE
CAS Registry Number: 563-41-7
Synonyms: Amidourea Hydrochloride; Aminourea Hydrochloride;
Carbamylhydrazine Hydrochloride; Hydrazinecarboxamide Monohydrochloride;
Hydrazinecarboxamide, Hydrochloride; Hydrazinecarboxamide, Monohydrochloride;
Semicarbazide Chloride; Semicarbazide, Monohydrochloride
Chemical Formula: CH^O'HCl
Molecular Weight: 111.54
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Not Found
ACGIH TLV: Not Found
IDLH: Not Found
Other Limits Recommended: Toxicity information: LDlo oral (rat)
10 mg/kg (-NIOSH/RTECS 1985)
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: Not Found
Specific Gravity (H20=l): Not Found
Vapor Pressure (mmHg): Not Found
Melting Point: 342-347°F, 172-175°C (Hawley 1981, p. 914); decomposes
at 347-365°F, 175-185°C (Merck 1983, p. 1214)
Vapor Density (AIR=1): Not Found
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Freely soluble in water with acid reaction
(*Merck 1976)
Appearance and Odor: Snow white crystals (*Hawley 1977)
-------
CAS Registry Number: 563-41-7
Page 2 of 3
SEMICARBAZIDE HYDROCHLORIDE
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
DEL: Not Found
Extinguishing Methods: (Non-Specific -- Poisonous Solid, n.o.s.) This
material may burn, but does not ignite readily. For small fires use dry
chemical, carbon dioxide, water spray, or foam. For large fires, use
water spray, fog, or foam (DOT 1984, Guide 53).
Special Fire Fighting Procedures: (Non-Specific -- Poisonous Solid,
n.o.s.) Wear self-contained (positive pressure if available) breathing
apparatus and full protective clothing (DOT 1984, Guide 53).
Unusual Fire and Explosion Hazards: When heated to decomposition, it
emits very toxic fumes of nitrogen oxides and hydrogen chloride (Sax 1984,
p. 2392).
SECTION IV -- REACTIVITY DATA
Stability: Unstable: Not Found
Stable: Not Found
Conditions to Avoid: Not Found
Incompatibility (Materials to Avoid): Not Found
Hazardous Decomposition or Byproducts: When heated to decomposition it
emits very toxic fumes of nitrogen oxides and hydrogen chloride (Sax 1984,
p. 2392).
Hazardous Polymerization: May Occur: Not Found
May Not Occur: Not Found
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Not Found
Skin: Not Found
Ingestion: Yes (Hawley 1981, p. 914)
-------
CAS Registry Number: 563-41-7
Page 3 of 3
SEMICARBAZIDE HYDROCHLORIDE
SECTION V -- HEALTH HAZARD DATA (Continued)
Health Hazards (Acute, Delayed, and Chronic): Toxic by ingestion
(Hawley 1981, p. 914).
Signs and Symptoms of Exposure: Not Found
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: (Non-Specific -- Poisonous Solid,
n.o.s.) Move victim to fresh air; call emergency medical care. Remove and
isolate contaminated clothing and shoes at site. In case of contact with
material, immediately flush skin or eyes with running water for at least
15 minutes (DOT 198^, Guide 53).
SECTION VI -- USE INFORMATION
As a reagent for ketones and aldehydes with which it affords crystalline
compounds having characteristic melting points (Merck 1983, p. 1214).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
(Non-Specific -- Poisonous Solid, n.o.s.) Isolate hazard area. Stay
upwind; keep out of low areas. Wear self-contained (positive pressure if
available) breathing apparatus and full protective clothing. Do not touch
spilled material. Absorb small spills with sand or other noncombustible
absorbent material and place into containers for later disposal. Take up
small, dry spills with clean shovel; place material into clean, dry
container and cover; move containers from spill area. Dike far ahead of
large spills for later disposal (DOT 1984, Guide 53).
-------
CAS Registry Number: 584-84-9
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31. 1985
Revision:
CHEMICAL IDENTITY -- TOLUENE 2,4-DIISOCYANATE
CAS Registry Number: 584-84-9
Synonyms: 2,4-Dicyanato-l-Methylphenylene; 2,4-Diisocyanato-l-Methyl-
benzene; 2,4-Diisocyanatotoluene; 2,4-TDI; 2,4-Toluene Diisocyanate;
2,4-Toluenediisocyanate; 2,4-Toluylene Diisocyanate; 2,4-Tolylene
Diisocyanate; 2,4-Tolylenediisocyanate; 4-Methyl-m-Phenylene Diisocyanate;
4-Methyl-m-Phenylene Isocyanate; 4-Methyl-Phenylene Diisocyanate;
4-Methyl-Phenylene Isocyanate; Benzene, 2,4-Diisocyanato-l-Methyl; Desmodur
T80; Di-Iso-Cyanatoluene; Hylene T; Hylene TCPA; Hylene TLC; Hylene TM; Hylene
TM-65; Hylene TRF; Isocyanic Acid, 4-Methyl-m-Phenylene Ester; Isocyanic Acid,
Methylphenylene Ester; Meta-Toluene Diisocyanate; Mondur TD; Mondur TD-80;
Mondur IDS; Nacconate 100; NCI-C50533; Niax TDI; Niax TDI-P; Rubinate TDI
80/20; TDI; TDI-80; Toluene Diisocyanate; Toluene, 2,4-Diisocyanato-;
Toluene-2,4-Diisocyanate; Toluylene-2,4-Diisocyanate; Tolyene 2,4-Diisocyanate;
Tolyene-2,4-Diisocyanate; Tolylene Diisocyanate; Tolylene-2,4-Diisocyanate
Chemical Formula: C_H.N 0
Molecular Weight: 174.15
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: Ceiling 0.02 ppm (0.14 mg/m3) (NIOSH/OSHA 1978, p. 180)
ACGIH TLV: TWA 0.005 ppm (0.04 mg/m3); STEL 0.02 ppm (0.15 mg/m3)
(*ACGIH 1984)
IDLH: 10 ppm (*Encyc Occupat Health and Safety 1983)
Other Limits Recommended: Occupational exposure to diisocyanates
recommended standard: TWA 0.005 ppm; Ceiling 0.02 ppm/10 minutes
(NIOSH/OSHA 1978, p. 180)
SECTION il -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 484°F, 251°C (*Merck 1983)
Specific Gravity (H20=l): 1.2244 at 20°C/4°C (*Merck 1983)
Vapor Pressure (mmHg): 1 at 80°C (*Clayton and Clayton 1981-82)
-------
CAS Registry Number: 584-84-9
Page 2 of 4
TOLUENE 2,4-DIISOCYANATE
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Melting Point: 67.1-70.7°F, 19.5-21.5°C .(*Merck 1983)
Vapor Density (AIR=1): 6.0 (*Clayton and Clayton 1981-82)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Reacts with water evolving carbon dioxide (Merck
1983, p. 1364).
Appearance and Odor: Colorless, yellow or dark liquid or solid with a
sweet, fruity, pungent odor (NIOSH/OSHA 1978, p. 180).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): 270°F, 132°C (*Merck 1983)
Flammable Limits:
LEL: 0.9% (*NFPA 1978)
UEL: 9.5% (*NFPA 1978)
Extinguishing Methods: Water gently applied to surface or foam may
cause frothing which will extinguish the fire (*NFPA 1978). If material
is on fire or involved in fire do not extinguish fire unless flow can be
stopped. Use water in flooding quantities as fog. Solid streams of water
may be ineffective. Cool all affected containers with flooding quantities
of water. Apply water from as far a distance as possible. Use "alcohol"
foam, carbon dioxide or dry chemical. Use water spray to absorb vapor
(Student 1981, p. 503).
Special Fire Fighting Procedures: If water gets below the surface of
the liquid, it will turn to steam and cause frothing. Full protective
clothing, including self-contained breathing apparatus, rubber gloves,
boots and bands around legs, arms, and waist should be provided. No skin
surface should be exposed (*NFPA 1978). Move container from fire area if
you can do it without risk. Cool containers that are exposed to flames
with water from the side until well after fire is out. Dike fire control
water for later disposal; do not scatter the material (DOT 1984, Guide 57)
Unusual Fire and Explosion Hazards: When heated to decomposition it
emits very toxic fumes of cyanide and nitrogen oxides (Sax 1984, p.
2590). Reacts violently with amines, alcohol, bases and warm water
causing fire and explosion hazards (DASE 1980, p. 907).
-------
CAS Registry Number: 584-84-9
Page 3 of 4
TOLUENE 2,4-DIISOCYANATE
SECTION IV — REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 871)
Conditions to Avoid: Avoid heating (*NFPA 1978).
Incompatibility (Materials to Avoid): Strong oxidizers, water, acids,
bases,0 amines, etc., cause foam and splatter (NIOSH/OSHA 1978, p. 180)
Hazardous Decomposition or Byproducts: When heated to decomposition,
it emits very toxic fumes of cyanide and nitrogen oxide (Sax 1984, p.
2590).
Hazardous Polymerization: May Occur: Yes (*Merck 1983)
May Not Occur:
Conditions to Avoid: Concentrated alkaline compound such as sodium
hydroxide or tertiary amines may cause run-away polymerization (*Merck
1983). Slow, not hazardous polymerization may occur above 113°C
(*CHRIS 1978).
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (NIOSH/OSHA 1978, p. 180)
Skin: Yes (NIOSH/OSHA 1978, p. 180)
Ingestion: Yes (NIOSH/OSHA 1978, p. 180)
Health Hazards (Acute, Delayed, and Chronic): Can cause death.
Contact with skin may cause allergic eczema. Substance is very corrosive
to eyes. Chronic exposure may cause chronic lung disease (*Gosselin 1976,
Weiss 1980, p. 871, DASE 1980, p. 907). As a vapor TDI is a powerful .
irritant to the respiratory tract. Chronic loss of respiratory function
may occur (*Gosselin 1976). Acute asthmatic bronchitis or frank asthma
may occur (*IARC 1972-85). A splash in the eyes of workmen has caused
keratitis and conjunctivitis (*Grant 1974). This compound causes
inflammation of the skin, also chemical pneumonitis and pulmonary edema
(*ACGIH 1980).
Signs and Symptoms of Exposure: Contact with skin causes redness and
pain. Contact with eyes causes redness, pain and blurred vision.
Inhalation causes shortness of breath, coughing, bronchospasm, and labored
breathing. Ingestion causes sore throat, abdominal pain, nausea,
vomiting, and diarrhea (*Merck 1983; *Gosselin 1976; *Grant 1974; *ACGIH
1980; Weiss 1980, p. 871, DASE 1980, p. 907). Neurological symptoms
include euphoria, loss of conciousness, headache, difficulty in
concentration, poor memory, confusion, irritability, and depression (*BR J
IND MED 33(2):65-71 1976).
-------
CAS Registry Number: 584-84-9
Page 4 of 4
TOLUENE 2,4-DIISOCYANATE
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air; call
emergency medical care. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. In case of contact with material,
immediately flush skin or eyes with running water for at least 15
minutes. Speed in removing material from skin is of extreme importance.
Remove and isolate contaminated clothing and shoes at the site. Keep
victim quiet and maintain normal body temperature. Effects may be
delayed; keep victim under observation (DOT 1984, Guide 57).
SECTION VI -- USE INFORMATION
Pol.yurethane foams; coatings in floor and wood finishes; sealers; paints;
concrete sealers for aircraft and tank trucks; elastomers in clay pipe
seals (*IARC 1972-1985); elastomers and coatings; and cross-linking agent
for nylon (Hawley 1981, p. 1030).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Shut off ignition sources; no smoking or flames in hazard area. Do not
touch spilled material; stop leak if you can do so without risk. Use
water spray to reduce vapors. Small spills: absorb with sand or other
non-combustible absorbent material and place into containers for later
disposal. Small dry spills: with clean shovel place material into clean, .
dry container and cover; move containers from spill area. Large spills:
dike far ahead of spill for later disposal. Keep unnecessary people away;
isolate hazard area and deny entry. Stay upwind; keep out of low areas.
Ventilate closed spaces before entering them. Wear positive pressure
breathing apparatus and special protective clothing (DOT 1984, Guide 57).
If material is not on fire and not involved in fire; keep sparks, flames,
and other sources of ignition away. Keep material out of water sources
and sewers. Build dikes to contain flow as necessary; attempt to stop
leak if without hazard. Use water spray to knock down vapors. If
material is leaking (not on fire), downwind evacuation must be considered
(Student 1981, p. 503).
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CAS Registry Number: 594-42-3
Page 1 of 4
EPA CHEMICAL PROFILE
INTERIM
Date: October 31, 1985
Revision:
CHEMICAL IDENTITY -- PERCHLOROMETHYLMERCAPTAN
CAS Registry Number: 594-42-3
Synonyms: Trichloromethanesulfenyl Chloride; (Trichloromethyl)Sulfenyl
Chloride; Clairsit; Methanesulfenic Acid, Trichloro-, Chloride;
Methanesulfenyl Chloride, Trichloro-; PCM; Perchloro-Methyl-Mercaptan;
Perchloromethanethiol; Perchloromethyl Mercaptan; PMM; Thiocarbonyl
Tetrachloride; Trichloromethanesulphenyl Chloride; Trichloromethylsulfenyl
Chloride; Trichloromethylsulphenyl Chloride
Chemical Formula: CC1.S
4
Molecular Weight: 185.87
SECTION I -- HAZARDOUS INGREDIENTS/IDENTITY INFORMATION
OSHA PEL: TWA 0.8 mg/m3 (*NIOSH/RTECS 1985)
ACGIH TLV: TWA 0.1 ppm, 0.8 mg/m3 (*ACGIH 1980)
IDLH: 10 ppm (NIOSH/OSHA 1978, p. 150)
Other Limits Recommended: Not Found
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS
Boiling Point: 297-298°F, 147-148°C (*Weast 1979)
Specific Gravity (H20=l): 1.6947 at 20°C (*ACGIH 1980)
Vapor Pressure (mmHg): 25 at 51°C (Weast 1984, p. C-374)
Melting Point: Not Found
Vapor Density (AIR=1): 6.414 (*Sax 1979)
Evaporation Rate (Butyl acetate=l): Not Found
Solubility in Water: Insoluble (*ACGIH 1980)
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CAS Registry Number: 594-42-3
Page 2 of 4
PERCHLOROMETHYLMERCAPTAN
SECTION II -- PHYSICAL/CHEMICAL CHARACTERISTICS (Continued)
Appearance and Odor: Oily, yellow (*ACGIH 1980) to orange-red liquid
(*CHRIS 1978). Odor is intensely unpleasant; strong, unbearable, acrid
(*CHRIS 1978).
SECTION III -- FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Found
Flammable Limits:
LEL: Not Found
UEL: Not Found
Extinguishing Methods: This compound is neither flammable nor a
serious fire hazard, although it will support combustion (*ACGIH 1980).
Fight small fires with dry chemical, carbon dioxide, water spray, or foam,
and large fires with water spray, fog, or foam. Move containers
containing this compound away from fire area if possible (DOT 1984, Guide
55).
Special Fire Fighting Procedures: Fight fire from maximum distance.
Dike fire control water for later disposal; do not scatter the material.
Positive pressure breathing apparatus and special protective clothing
should be worn (DOT 1984, Guide 55).
Unusual Fire and Explosion Hazards: Very irritating vapors formed from
hot material; may form phosgene gas, hydrogen chloride, and sulfur dioxide
(Weiss 1980, p. 739).
SECTION IV -- REACTIVITY DATA
Stability: Unstable:
Stable: Yes (Weiss 1980, p. 739)
Conditions to Avoid: Reacts with water only when hot to give
carbon dioxide, hydrochloric acid, and sulfur (Weiss 1980, p. 739).
Incompatibility (Materials to Avoid): Reacts with iron or steel,
evolving carbon tetrachloride. Corrosive to most metals (Weiss 1980, p.
739).
Hazardous Decomposition or Byproducts: At high temperatures this
compound will decompose to carbon tetrachloride, sulfur chloride, heavy
oil polymers, phosgene gas, hydrogen chloride, and sulfur dioxide (Weiss
1980, p. 739).
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CAS Registry Number: 594-42-3
Page 3 of 4
PERCHLOROMETHYLMERCAPTAN
SECTION IV -- REACTIVITY DATA (Continued)
Hazardous Polymerization: May Occur:
May Not Occur: Yes (Weiss 1980, p. 739)
Conditions to Avoid: Not Found
SECTION V -- HEALTH HAZARD DATA
Routes of Entry: Inhalation: Yes (*Sax 1975)
Skin: Yes (*CHRIS 1978)
Ingestion: Yes (»Sax 1975)
Health Hazards (Acute, Delayed, and Chronic): May cause death or
permanent injury after short exposure to small quantities (*Sax 1975);
strong irritant to eyes and skin (*Hawley 1977). Inhalation may cause
severe irritation of the upper respiratory tract. It also is a strong
irritant to the eyes and skin. Brief exposure to lower concentrations may
produce central nervous system depression and lung, liver, and heart
congestion. Severe exposures may be fatal. Exposure of eyes may lead to
severe conjunctivitis or corneal damage. The liquid is irritating to the
skin, and may be absorbed through the skin in quantities sufficient to
cause general toxic effects. Ingestion may cause damage to mucous
membranes and result in pain and burning of the mouth and throat, nausea,
vomiting, cramps, and diarrhea. In severe cases, tissue ulceration and
CNS depression may occur (-CHRIS 1980).
Signs and Symptoms of Exposure: Symptoms of exposure include eye
irritation, conjunctivitis, and skin irritation. Ingestion causes burning
of mouth and throat, nausea, vomiting, cramps, and diarrhea ("CHRIS 1978,
1980). Persons exposed at less than 45 ppm noted strong eye, throat, and
chest irritation, as well as nausea (*ACGIH 1980).
Medical Conditions Generally Aggravated by Exposure: Not Found
Emergency and First Aid Procedures: Move victim to fresh air and call
for emergency medical care. Give artificial respiration if necessary. If
breathing is difficult, give oxygen. If skin or eyes are exposed, flush
with running water for at least 15 minutes. It is extremely important to
remove this material from skin as quickly as possible. Remove and isolate
contaminated clothing and shoes. Keep victim quiet and maintain normal
body temperature. Effects may be delayed; keep victim under observation
(DOT 1984, Guide 55).
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CAS Registry Number: 594-42-3
Page 4 of 4
PERCHLOROMETHYLMERCAPTAN
SECTION VI -- USE INFORMATION
This compound is used as a fumigant, dye intermediate, and in other
organic syntheses (*ACGIH 1980).
SECTION VII -- PRECAUTIONS FOR SAFE HANDLING AND USE
(Steps to be Taken in Case Material is Released or Spilled)
Do not touch spilled material; stop leak if this can be done without
risk. Use water spray to reduce vapors. For a relatively small spill or
leak, isolate the area in all directions for 220 feet. For a larger spill
(e.g., from a tank) first isolate the area for 450 feet in all directions,
and then evacuate in a downwind direction an area 1.1 miles in width and
1.6 miles in length (DOT 1984, Guide 55 and Table of Isolation and
Evacuation Distances).
Wear positive pressure breathing apparatus and special protective
clothing. Take up small spills with sand or other noncombustible
absorbent material and place into containers for later disposal. For
large spills dike far ahead of spill for later disposal. It may be
necessary to seek emergency assistance (DOT 1984, Guide 55).
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