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Index to  the Report  of the Secretary's
Ccr^mission -on Pesticides  and Their
r::s!afionshlp  f© Environmental  Health
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Ivefionsl Ubrary of Medicine, BefRejdis, Mt
r.^vironmeiit8i  Pirotection Agency, Washington,  D C  Offks of Pesticide
Programs

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          TOXICOLOGY INFORMATION PROGRAM

    U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE
                   Public Health Service
                 National Institutes of Health

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                       '?" •< **^l***>""7*
                        [WO
                                 TUT
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         TOXICOLOGY INFORMATION PROGRAM
m
                 Index to the Report
                         of the
       Secretary's Commission  on  Pesticides
                          and

                 Their Relationship

                           to

                Environmental Health
        by Sharon L. Valley, Ph. D.

      Toxicology Information Program

        National Library of Medicine
R."
v-1
U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE
             Public Health Service
           National Institutes of Health

         NATIONAL LIBRARY OF MEDICINE
              8600 Rockville Pike
           Bethesda, Maryland 2C014

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     DHEW  Publication  No.(NIH)72-269
Tor ilk by the Superintendent of Documents, U.8. Qonrmnent Printing OBta
              WMhlnfton,D.C.:

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               TABLE OF CONTENTS
                                              Page
 INTRODUCTION  	«
•'- CHEMICAL SUBSTANCE INDEX	1-72
 SUBJECT INDEX  	73-205
•-- BIBLIOGRAPHY  	207-310
                            II

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u
                                                                                                           1

                                      INTRODUCTION                                              .-'
                                                                                                           Y

       The indexes in this publication were designed to assist users in rapidly finding Information in
       The  Report  of the  Secretary's Commission  on  Pesticides arj Their Relationship to
       Environmental Health,  published by the U.S. Government Printing Office, December 1969.               •
       This publication consists of three indexes: a Chemical Substance Index; a Subject Index, and a               \
       KWogrcfhy.                                                                                        V
                                                                                                           J
       The Chemical Substance Index and the Subject Index are arranged alphabetically by main
       terms. Free text entries under each main term are arranged in increasing page number sequence.
       Therefore, the user is encouraged to browse  through these entries (under one or more main
       terms) to assure that all concepts have been located.

       The Bibliography is arranged alphabetically by first author; citations are presented as they were
       published in the original Report.  Duplicate citations were removed but annotated as follows:
       number(s) in parenthesis after the citation indicate  the Report page(s) on which the reference
       was specifically cited and/or discussed within the text. Numbers following the citation.' at not
       in parenthesis, indicate the Report poge(s) on which the reference was listed.

       In order 'o prepare these indexes, the entire text of The Report of the Secretary's Commission
       on Pesticides and Their Relationship to Environmental Health, including the references,  was
       entered into an on-line, whole  text computer search system (Mead Data Central, Mead Data
       Corporation). On-line, interactive indexing was performed using color cathode ray tube r- .riev U
       equipment. The entire Report is still in an on-line system for search purposes.

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                    CHEMICAL SUBSTANCE INDEX
Subject

AATREX
   Sec ATR/.ZINE
ABATE
   Use in control of mosquito larvae    60
   Replacement for DDT, selective     60
   New pesticides                   60

   Organic phosphates               64
   Importance in public health         64
   Organic phosphate phenyl
      derivatives                   64
   Use rates                       64

   Resistance, mosquitoes            127

ACARABEN
   See CHLOROBENZILAIE

ACARALATE
   See CHLORPROPYLATE

ACETYLCHOLINE
   Effects of cholinestcrase
      inhibitors                    411

   Behavioral effects                412

   Effects on schizophrenics          418

   Synergism, mechanisms            524

ACETYLETHYLENEIMINE
   Chromosome aberrations in
      higher plants                 583

PIN-ACETYL-METHYL-
   PIIOSPHONOFLUORIDATE
   SeeSEMAN

ACRITET
   See ACRYLONITRILE

ACROLEIN
   Herbicides, Miscellaneous          70
   Toxicity                        70
   Uses                           70

   Tentative guidelines for
      herbicides                   124
   Tentative guidelines for crops       1 24
   Subject                       Page

   Other reactive compounds         609
   May affect DNA    :..           609

ACRYLONITRILE
   Other reactive compounds         609
   May affect DNA                609

   Organism, dose, effect            639

   Products, producers              645
   Application                    645
   Chemical name, formula          645
   Physical properties              645
   Product form                   645
   Oral toxicity LD-SO              645
   Major end uses                  645

ACTIDONE
   See CYCLOHEXIMIDE

ADENINE
   Chromosome abci-at ions          591
   Mutagenic effect                591

   Mutagenic DNA alterations        605
   DNA bases                     60S

ADEMNE ARABINOSIDE
   Chromosome aberrations in
      higher plants                583

ADENINE XYLOSIDE
   Chromosome abet rations in
      higher plants                583

AFLATOXIN
   Carcinogen                     251

AGRIMYC1N
   Antibiotics used as fungicides      66
   Bactcricide                     66
   Use rate                       66

   Ancillary methods, bacterial       572

   Methods, based on resistance       573

ALANAP
   See NAPTALAM

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                            CHEMICAL SUBSTANCE IN )EX
ALAR
   Growth retatdants
   UK in agriculture
   Replacement of, by new
      soil insecticides
   Worldwide usage, 1966

   Rice crops
   Use to control pests

   Cereal crops
   Use to control pests

   Sugar beet crops
   Use to control pests

   Sugarcane crops
   Use to control pests
74
74
ALCOHOL
   Use as wash for parathion,
      decontamination of
      human skin                    400

   Behavioral effects of solvents        417
   Solvents in air, resembling
      alcohol effects                  417

   Influence upon behavior            419

ALDRIN
   Persistence                         9
   Environmental contamination        9

   Needed knowledge of sample
      composition, purity             11

   Decrease usage over next 2 years     26

   Blood level, rncssurc of exposure     33

   Controlled human studies           35

   Use in agriculture, crops            48

   Uses                             51

   Sates                             52

   Use for teti.-.'te control             S3

   Use, foreign countr.c.              SS
60
   Chlorinated aryl hydrocarbons      63
   Uses                             63
84

85
85

86
86

88
88

89
89
Termi'es                          90
Use to control pests                 90

Use as soil insecticide              104
Control of com rootworm          104

Atmospheifc contamination         113

Concentration in lakes             119

Potable water supply               121

Standards, limits                  122

Fate of, in rice puddles             124

Water concentrations              128

Examination of estuaries           129
           Cucumbers grown on treated
              soil residues in

           Residues, in seed crops
           Conversion in plant cells

           Acceptable daily intake,
              FAO-WHO
Effect on phytoplankton

Effect on crab larvae

Mortality of wild-life
Controlled human volunteer
   studies
Occupational exposure,
   blood levels
                                 132
                                 133
                                 133
                                 137

Dietary intake                    138

Uptake by f bnts                  144

Decrease usage o\ :r next 2 years     180

Deaths to wild-life, from
   treated cereal seed dressing*      200
                                 207

                                 209

                                 213
Blood level, measure of exposure     232


                                 233
Actions to improve protection
   of public health                239
No extension of present uses        239
                                 268
Acute oral toxicity, LD-50          313
Acute dermal toxicity. LD-50       313

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                           CHEMICAL SUBSTANCE INDEX
   U.S. pesticide production, annual

   Occupational exposure

   Occupational exposure, results

   Occupationally related
      skin conditions

   U.S. pesticide production, 1966

   HEOD, residue of aldrin
      and dicldrin

   Occupational exposure, results
   Effects on conditioned
      reflexes, cats

   Polypeuropalhy, humans

   Method of analysis, blood

   Tumohgenicity testing, results
   Registered for use on food crops

   Enzyme induction studies
      in progress

   Effect of feeding, rats, on
      effect of subsequent
      parathion poisoning

   Effect on tissue storage
      of DDT

   Blood levels, occupational
      exposure

   Effect on tissue storage

   Metabolism of

   May affect DNA

   Use in agriculture
   Insecticide

ALLETHRIN
   Botanicals, insecticides
   Synthetic "pyrethrin"
   Formulation as dusts, sprays
      and aerosols
   Formulation with syrergists
   Toxicity to mammals
   Use around livestock
   Use around homes
315

349
351

366

382


386
409

409
417

448

470
470

520


ALLYL ALCOHOL
Other reactive compounds
May affect DNA
ALPHA-BHC
Sec after BHC
AMIBEN
Benzoic acid herbicides
Persistence in soil
Toxicity to mammals
Use in agriculture
Use rates
U.S. sales
Herbicides, preemergence
Widely used in agriculture
AMINOCARE
See MATACIL

6-AMINO-NICOTINAMIDE
Testing for increase anomalies

Testing for increase anomalies
2-AM1NOPURINE
Mutations in higher plants
DNA alterations

609
609



68
68
68
68
68
610
610
610




669

672

584
605
524


528


538

539

559

609

610
610
 62
 62

 62
 62
 62
 62
 62
AMINOPTERIN
   Mutations, chromosome aberrations
      in higher plants                583

4-AMINOPYRIDINE
   Use in bird control                 73

AMITROL
   Needed knowledge of sample
      composition, purity             11

   Heterocyclic nitrogen derivatives     69
   Herbicides                        69
   Use in agriculture                  69
   Toxicity to mammals              69
   Use rate                          69
   Persistence in soil                  69

   Mode of action                   604
   Inhibitor of potphyrin,
      chlorophyll synthesis           604

   No significant increase of
      anomalies, as tested            674

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                         CHEMICAL SUBSTANCE INDEX
ANISYLACETONE
   Synthetic insect ^ttractar.*
   Use in controlling fruit
      and melon (lies

ANTHRAQUINONE
   I'se for bird control

   Inhibition of DNA synthesis,
      possibly

ANTIMYCIN
   Antin.ycin, use as fish toxicant

   Antibiotic, synthesized by fungi
   Toxicity to invertebrates
   Toxicity to fish
   Degradation rate in water

ANTU
   Rodenticides, selectivity
      for rats
   Use for Norway rat control

   Judged not positive,
      tumorigenicity study
   Registered but not for use
      on food crops

APHOLATE
   Ethyleneimincs
   Compounds known to affect DNA

AQLAL1N
   See ACROLEIN

ARAMITE
   Needed knowledge of sample
      composition, purity

   Judged positive, tumor induction
   Registered for use on food crops

   Tumor incidence, raring

   Sulphates
   Known to affect DNA

ARASAN
   SecTHIRAM

ARSENIC
   Salts of, persistence in soil

   Salts of, inorganic rodcnticides

   Residues in food samples
   Daily intake

75

75

73

609
11
13
213
*> 1 1
21 y
213
213

•71
12.
72

475
475

606
606





11
470
470

489

606
606



45

71

137
137
Use in orchards
Persistence
Effects of, on plants

Use, domestic
Accidents, by industry.
by occupation
Poisonings, humans
Compounds use as plant growth
regulators, toxicity
Sodium KI senile-containing
herbicide, accidents, human
Chronic poisoning, phnses
Dermatitis
Occupational^ related
skin conditions
Urine, indicator of exposure
Poisoning, treatment of
ARSENIC SULFIDE
Inorganic rodentictde*
ARSENIC TRIOXIDE
Inorganic rodcnticides
ATRATRONE
Products, producers
Application
Chemical name, formula
Physical properties
Oral toxicity, LD-50
Major end-uses
ATRAZINE
Heterocyclic nitrogen derivatives
Herbicides
Use in agriculture
Toxicity to mammals
Use rate
Persistence in soil
Persistence
Use in agriculture

Urine, indicator of exposure

Tumorigenicity testing
Registered for use on food crops

145
145
145

147

154
158

205

362
362
365

366
448
451

72

72

645
645
645
645
645
645

69
69
69
69
69
69
104
104

448

475
475


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                          CHEMICAL SUBSTANCE INDEX
   Tumorigenicity testing, rating       490

   Pesticides mutations in bailey       584

   Picemcrg :ncc herbicide             610
   Use                             610
   Herbicide                        610
   Use in agriculture                  610

   Organism tested, dose, effect        639

ATROPINE
   Treatment for organophosphorus
      compounds                    412

   Atiopine, ovcrtrcatment
      of poisoning                   416

   Antidote in humans, animals        426

   Treatment in pesticide poisonings    450

   Mechanism of action               *S2
   Antagonist in pesticide poisoning    452

   Treatment in pesticide poisoning     •  -

   Treatment of carbamate
      poisoning in mice              454

   Antidote for effects in
      pesticide poisoning             534
   Radiation, organophosphate,
      exposure to                   534

AVADEX
   Needed knowledge of sample
      composition, purity             11

   Carbamates                       70
   Prccmergent herbicides             70
   Persistence in soil                  70
   Toxicity to humans               70
   Toxicity to warm-blooded animals   70

   Judged positive,
      tumor induction               470
   Registered but not for use
      on food crops                  470

   Tumor incidence,  rating            489

   Carbamatcs                       491
   Tumorigcnic activity, rating         491

AVITROL
   See 4-AMINOPYRIDINE
AZASERINE
   Chromosome aberrations           591
   Mutagenic effects                 591

AZINPHOSMETHYL
   See GUTHION

AZOBENZENE
   Tumor incidence, priority
      for testing                     473
   Registered but not for use
      on food crops                 473

AZODRIN
   Grasshopper control               92
   Poor or lack of
      grasshopper control             92

BAL
   dictating agent for heavy
      metal poisoiur g                451
   Mcchan ism of action               451
   Effectiveness in arsenic
      poisoning                     451
   Effectiveness in mercury
      poisoning                     451
   Effectiveness in lead poisonm?      451

BALAN
   Dinitroaniline herbicides            70
   Preemcrgcnt herbicides             70
   Use in Held and crop
      weed control                   70
   Use rates                        70
   Persistence                       70
   Toxicity to humans                70
   Toxicity to warm-blooded animals   70

BANOL
   Low protein diets, rats             532
   Toxicity                         532
   Anticholinesterase insecticide       532

BANVEL D
   See DICAMBA

BARBAN
   SeeCARBYNE

BARIUM CARBONATE
   Inorganic rodcnticides             72
   Use rates                        72

BARTHR1N
   Botanical insecticide               63

   Ester hydrolysis, oral
      administration                 547
   Metabolism in rats, rabbits         547

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                          CHEMICAL SUBSTANCE INDEX
BAYCON
   Carbain.'te insecticide              53
   Resi;!vtcc to other pesticides       S3
   Res)Stai<--e '.n termites              S3

   Carbamatts                      65
   Mcxle of action                   65
   Major use                        65
   Use rate                         65
   Restricted use, for cockroaches
      and other pests                65

   Insecticides for household use       151
   Use in controlling chlorinated
      hydrocarbon resistant
      cockroaches    •               151

   Toxicity symptoms in !iumans       348
   Duration of action                 348
   Poisoning by carbamates            348
   Reversible cholinesterase
      inhibition                     348
   Useof2-PAM                    348

   t-'ield tests in Nygeria and Iran       361
   Poisoning of humans               361
   Clinical symptoms                 361

   Ophthalmic effects, topical          367

   Effects or fibers, residents        369
   Signs and syi.jp. •• it»               369

   Experimental carbamale pesticide,
      related to Baygon. effect
      in rats                        410

   Effects on sprayers, residents        417
   Effects on cholinesterase            417
   Effects from prior spraying          417

   Urine, indicator of exposure         448

   Metabolism in housefUes.
      effect of MDP compounds       S5S

   Chemical structure                5S7

   Detoxification product             558

   MDP compounds, synergixts         SS9

BAYLUSCIDE
   Use in snail control                72
   Use in lamprey control             72
BAYTEX
   See FENTHiON

BF.NEFIN
   SeeBALAN

BENLATE
   Converted to epoxide,
      found in tady fat             609
   May affect UNA                 60?
   Base analog                     CD9

BENS*.-IDE
   See BETASAN

BENZAC
   Benzoic acid compound            68
   Herbicides                        63
   Persistence in soil                 68
   Toxicity to mammals              68
   Use in agriculture                 68
   Use rates                        68

BENZENE HEXACHLORIDE
   SeeBHC

3,4-BENZPYRENE
   Sesamin coctrcinogenic
     . with 3,4-benzpyrene           543

   Administration with MDP
      synergist, liver damage          S *4

   F.ihancemem of toxicity with
      otlier chemicals               546

BETASAN
   Amide derivatives                 70
   Use as herbicides                  70
   Us; in agriculture                 70
   Use in home and garden products    70
   Preemergent herbicides             70
   Persistence in soil                 70
   Use rates                        70
   Toxicity                .         70

N6-BENZYLADENINE
   Cytokinins                       74
   Uses                            74
   Use rate                          74

N6-BENZYL-9-TETRA-
   HYDROPYRANADENINE
   Cytokinins                       74
   Uses                            74
   Use rate                          74

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                           CHEMICAL SUBSTANCE tt'DEX
BHC
   Persistence, contamination
      of environment                  9

   Insccticidal properties
      recognized, 1940               45

   Chlorinated aryl hydrocarbons       63
   Use in agriculture                  63

   Use on world crops                 84
   Use on fruit crops
      in foreign countries             84

   Rice crops                        85
   Cereal crops                       85
   Use of BHC to control pests         85

   Vegetable crops                    87
   Use of BHC to control pests         87
   Potato crops                       87
   Limited use of BHC                87

   Sugar beets                       88
   Use of BHC to control pests         88

   Sugarcane                         89
   Use of BHC to control pests         89
   Tobacco                          89
   Use of BHC to control pests         89

   Oilseeds                          90
   Use of BHC to control pests         90
   Locusts, control of with BHC        90
   Grasshopper control
   Losses of cattle products due to
      grasshopper infestations
                                 91

                                 91

Drift from aerial spraying           108

Efficiency of mode of application    1C'9

Atmospheric contamination studies  114
   Pesticides in rain water,
      alpha BHC
                                 116
   Removal of, from water treatment   123
   Concentrations in treated
      and untreated water            123

   Foods of animal origin             138
   Source of BHC intake in diet       138

   Residue retention in cow's milk     140
                                            Actions to improve protection
                                               or public health                239
                                            No extension of present
                                               uivsofBHC                   239

                                            Residues in human adipose tissue    269
                                            Further information on kinetics
                                               of beta BHC in mail, animals
                                               desirable                      269

                                            Human pesticide residues           320

                                            BHC concentrations,
                                               negroes vs whites               322

                                            Levels in Great Britain              328

                                            Morbidity effects of
                                               cccupational exposure           347

                                            U.S. ptsticide production. I966     382

                                            S"nagc of beta BHC by females
                                               vs males
   Effect of fat diet, effect on
      toxkity. storage
                                               Use in household formulations
                                            Human adipose residues
                                                                             429
   Concentration of, in human milk
      relationship to other chemicals   449

   Ingcstion of flour
      contaminated with BHC        450
   Toxkity. effects from             450

   Residues                        525

   Twecn 20, effect on tissue levels
      ofbeta-BHC.rats              526
                                                                                532
                                               Concentration in tissues, humans    538
                                               Household use of pesticide*         538
                                    611
alpha-BHC
   The water route                   116
   Rainwater, containing alpha BHC    116
   Concentrations in rainwater         116
                                    331
                                         beta-BHC
                                            Residues in human adipose tissue    269
                                            Desirability of additional
                                               information on kinetics         269

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                         CHEMICAL SUBSTANCE INDEX
   liu;nan adij'-ose re jdues           331

   Storage of. in females vs mates      429

   Effect of increased tat in
     diet on storage                526
   Twcen 20, effect on tissue levels    S26

GAMMA BIIC
   See LINDANE

BIDRIN
   Organophosphorous compounds    64
   Al'phatic derivatives              64
   t«e rates                       64

   Acute oral toxkity. LD-SO         312
   Acute dermal toxicity, LD-SO      312

   Reports of occupationally
     related skin conditions         366

   Accidental exposure, human       367
   Orpanophosphorous compounds    367
   Effects on eye                   367

   Metabolism in houscflics           555
   Effect of M DP compounds on      555

   Organophosphates                665
   Qtolincstcrasc inhibiting
     insecticides                   665
   Teratogenic in chick embryos      665

BINAPACRYL
   See MOROC1DE

BIPHENYL
   Tumor incidence, testing          473
   Registered for use on food crops    473

   Piperonyl butoxide. inducer of
     biphenyl metabolism           554
   Effects of pipcronyl butoxide
     on hydroxylation of biph^nyl
     in liver microsomes of mice      554

BIS1SOPROPYLAMIDO
   FLUOROPHOSPHATE
   SeeMIPAFOX

BISMUTH
   DITHiOCARBAMATE
   Tumorigenicily testing, rating      491

BOMBYKOL
   Insect attra rtants                 ?$
BORDEAUX MIXTURE
   Inorganic fungicides               66
   Use in agriculture                 66
   Use rates                        66

BOTRAN
   SccDICIIl.ORAN

BROMAC1L
   Herbicides, mi«cellaneous
      category                      70

   Base analogs                    609
   Converted into epoxides,
      in body fat                  609
   May affect DNA                 609

BROMINE
   Fumigants containing bromine     198
   Bromide residue in soil            198
   Bromide residues in milk          198

   Atoms on Frcons                 545

   Chromosome aberrations in
      higher plants                 583

5-BROMODEOXYCYTIDINE
   Mutations in higher plants         583

5-BROMODEOXYl'RIDINE
   Mutations in higher plants         583

   Chromosome aberrations          591
   Muu^-mc effects                 591

BROMOMETHANE
   Bromides and chlorides            606
   Affect DNA                     606
   Mutations, chromosome alterations  606

BROMOPROPANF.
   Bromides and chlorides            606
   Affsct DNA                     606
   Mutations, chromosome alterations  606
5-BROMOURACIl.
   DNA alterations


BROMOXYNIL
   See BUCTRIL

BUCTRIL
   Nitrite herbicides
   Toxicity to mammals
   Us« rates
605
 70
 70
 70

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                        CHEMICAL SUBSTANCE INDEX
BUdR
   Reasttnce to 9UdR              588
   Treatment of Chinese hamster
      cells with BUdR              S88

BUTACIDE
   Tumor testing                   475
   Registered Tor use on Toed crops    475
   Cbripare with piperonyl buloxide   475

   Tumorigenicity testing, rating      492
   Piperonyl buloxide tested
      as Butacide                  492
   Development of lymphomas       492

BUTOXY PROPYLENE
   GLYCOL
   Insect repellents                  75

3UTYLATE
   See SUTAN

BUTYLATED
   HYDROXYANiSOLE
   I'ood Additive                   583
   Chromosome aberration in
      higher plants                 583

BUTYIATED HYDROXY
   TOLUENE
   Food additive                   583
   Chromosome aberrations in
      higher plants                 583

N-BUTYL METHANE
   SULIONATE
   Mutations in higher plants         584

   Mutations                      585

BUTYLSORBATE
   Insect attraction                 75

BUX-TEN
   Carbamate insecticides             65
   Mode of action                  65
   Use in agriculture                65
   Use rates                       65

   Carbamates                     607
   May affect DNA                 607

   VS. safes, use in agriculture        610
   Insecticide                      610

CACODYLIC ADD
   Metal-organic compounds         68
   Used to control crabgnss.
      weeds                      68
   Tumorigenicity testing, rating      475
   Registered but not for use
      on food crops                475

CADMIUM CHM3RIDE
   Inorganic fungicides               66
   Use in agriculture                 66
   Use rates                        66

CADMIUM. DIETHYL
   DrrmOCARBAMATE
   Tumorigcnicity testing, rating      491

CAFFEINE
   Chromosome aberrations in
      higher p'ants                 584

   Chroniosnrrc aberrations          591
   Mutagenic effects                591

   Study of synergistk effect
      with X-fjys                  598
   Results of dominant lethal
      mutation testing              598

CALCIUM ARSENATE
   Inorganic insecticides             62
   Use restricted, toxicity,
      persistence                   62

   Inorganic herbicides              68
   Use rales                       68

   Possible inclusion in slug
      and snail baits                73

   U.S. pesticide production, 1966     382

CALCIUM CYANlDt
   Inorganic rodenticides            72
   Use rates                       72

CALCIUM DISODIUM
   EDETATE
 SeeEDTA

CAPTAN
   Needed knowledge of sample
      composition, purity            11
   Chlorine-containing fungicide       67
   Uses                           67
   Use rate                        67

   VS. Pesticide production, annual    315

   Occupational dermatitis           36S

   Occupational exposure,
      allergic dermatitis             399

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                       CHEMICAL SUBSTANCE INDEX
   Mutagenic effects
438
Spsaying of farm animals.

Tumorigenicity testing, results
Registered for use on food crops
Tumorigenicity testing, results
Diet, effect on acute toxkity
Half -life in serum
Mutagenic hazard
Fungicide
Use in agriculture

Organism tested, dose, effect

Products, producers
Application
U.S. patent numbers
Chemical names, structure
Physical properties
Oral toxicity. LD-50
Major end uses
Tcratogenk
Teratosenic in chicken embryos
Production of abnormal fetuses

Testing for increase anomalies

CAPTAX
See 2-MERCAPTO-
BENZOTHIAZOLE

CARBARYL
Needed knowledge of sample
composition, purity

New pesticides, rarbamatei
Uses, insect control
Non-persistence
Grasshopper control
Non-persistent pesticides
mm 	
Usage
Persistence, in comparison with
malathion, parathion
Residues on cabbage, eggplants

Residues
Calculated daily intake

Acceptable daily intake,
FAO-WHO

473
473
490
532
603
603
610
610

639

645
645
645
645
645
645
MS
658
664
666

673







11

59
59
59
92
104
1 /U
IIM
104
134

136
136


137
residues

Home canning, removal of residue
Susceptibility of bees to
Effect on crab larvae
Morbidity effects of
occupational exposure
Exposure, symptoms, usage

Occupational exposure, poisonings

Penetration of

Sample skin matrix

Effect on self-protective
responses, rats

Effect on rats, adult vs weanling
Urino, indicator of exposure
Treatment of poisoning
Tumorigenicity testing, results
Registered for use on food crops

Tumorigenicity testing, rating

Synergism with MDP compounds

Mutations in barley

May affect DNA

Use in agriculture
Insecticide
Organism tested, dose, effect

Products, producers
Application
U.S. patent number
Chemical name, formula
Physical properties
Product foims
Oral toxicity. LD-50
Major end uses

Teratogenidty testing, results

Teratogenic studies, results
139

141
208
209

345
348

361

403

405


410

427
448
452
469
469

491

542

584

607

610
610
639

646
646
646
646
646
646
646
646

658

664
10

-------
                        CHEMICAL SUBSTANCE INDEX
   Increase in abnormal fetuses       666
   Cystic kidneys, with
     pipcronyl butoxide            666

   Testing for increase anomalies      673

   Testing for increase anomalies.
     with nicotinamide             674

CARBOFURAN
   See FURADAN

CARBON DISULFIDE
   Use early as pesticide             45

CARBON TETRACHLORIDE
   Eff.-cl on methoxychlor toxkity    430
   Liver damage, rats                430

   Effect on EEC patterns           4SI
   Chlorinated solvent*              451

CARBOPHENOTH1ON
   Set- TRITHION

CARBYNE
   rarbamatcs                     70
   Pro-emergent herbindrj           70
   Use ntes                       70
   Toxicity to humans               70
   Toxicity to warm-blooded animals   70

   Carbamates and thiocarbamates     607
   May affect CNA                 607

CARZOL
   Carbamates and thtocaibamatcs     607
   May affect DNA                 607
CASORON
   Nitrile herbkides                70
   Use in weed control              70
   Persistence in soil                70
   Use rates                       70

CCC
   Tumor incidence, priority
     for testing                   473
   Registered but not for use
     on food crops                473

   Tumorigenkity testing, rating      489

CDAA
   Amide derivatives                70
   Use as herbicides                70
   Persistence in soil                70
   Use rates                       70
   Dermal  toxkity                 70
   Toxkity                       70
   Carbamates and thiocarbamates     607
   May affect DNA                 607

   U.S. sales, use in agriculture        610
   Herbicide                       610

CDEC
   See VEGEDEX

CEEPRYN
   Chromosome aberrations in
      higher plants                  583

CERESAN M
   See ETHYLMERCURY
   CHLORIDE

CERTRCL
   Sec IONXYNIL

CHARCOAL
   Use of charcoal dinted runways
      in studying DDT effect on
      locomotion                   409

   Use in poisoning cases             450

   Treatment of cows, with
     phenobarbital, effect on
     dicldrin levels                529


CHIPCOTE 25
   Organic mercury compounds       66
   Uses                           66
   Use ntes                        66

CHLONITRAI.ID
   See BAYLUSCIDE

CHLORANIL
   Chlorine-containing fungicides       67
   Use rate                         67
   Uses                    ,       67

   Tumorigcnicity testing, priority
      for testing                   473
   Registered but not for use on
     Tood crops                   473

   Tumorigenicity testing, rating      490


CHLORDANE
   Persistence                       9
   Environmental contamination       9

   Persistence                       26
   Decrease usage over next 2 years     26
                                                                           11

-------
                    CHEMICAL SUBSTANCE INDEX
Replacement by diazinon
Rcastcncc to
Use in termite control

Usage, foreign countries

Chlorinated aryl hydrocarbons
Uses

Worldwide usage

Persistence

Air contamination, analysis or

Ground waters, analysis of

Potable water supply
Standards, limits

Usage, domestic
Use against ants, cockroaches
Insecticides for household use

Accidents, by industry, by
occupation

Persistence
Decrease usage over next 2 years
Effect on phyioplanktcn
Acute oral toxicity. LD-50
Acute dermal toxicity, LD-50

U.S. pesticide production, annual
Effect on excitability of
nervous system

Occupational^ related skin
conditions
/
Henutotogical disorders

Occupational exposure, results
Accidental ingestion of

Blood dyscnsias

Liver changes, rats

Enzyme induction

Enzyme induction, measurements
in progress
53
53
53

55

63
63

84

104

113

117

121
122

147
151
151


154

ISO
180
207
313
313

315
360


366

372

312
312

389

435

S18


520
Effect of feeding, rats, on
subsequent parathion poisoning

Diet, effect on acute toxicity

Use in agriculture
Insecticide

Use in household formulations

Embryotoxicity in rats, dogs

GAMMA CHLORDANE
Enzyne induction by other
chlorinated hydrocarbons, rats

CHLORIENSON
See C VEX
CHLOROBENZILATE
Needed knowledge of sample
composition, purity
Compounds related to DDT
Use rates
Use as insecticide
Use as miticide

Acute oral toxicity, LD-50
Acute dermal toxicity
Tumorigcnicity testing, results
Registered for use on food crops
Compounds related to DDT,
structurally
Tumorigcnicity testing, rating
2-CHLORCM.6-bis
(ETHYLAMINO)-S-
TRIAZINE
See SIMAZ1NE

2-CHLOR >N-DIALLYL
ACET/.MIDE
Allergic contact sensitization to
Occupational exposure, humans

2-CHLORO-2-DIETHYL-
CARBAMOYL-1-METHYL
VINYL DIMETHYL
PHOSPHATE
See PHOSPHAMIDON

CHLORODIMETHYLAMINE
Nitrogen •nustards
Mutation* in Neurospora

524

532

610
610

611

664



S2C





11
63
63
63
63

313
313
470
470

489
489







399
399








S85
585
12

-------
                        CHEMICAL SUBSTANCE INDEX
BIS (2-CHLOROETHYL)
   ETHER
   Needed knowledge of sample
      composition, purity            11

   Judged positive tumor induction     470
   Registered but not for use
      on food crops                 470

   Tumor incidence, rating           489
CHLOROETHYL METHANE
   SULFONATE
   Mutations in higher plants         584

   Mutations in Ncurospora           585

2-(CHLOSOETHYL)
   TRTMETHYLAMMONIUM
   CHLORIDE
   See CCC

CHLOROFORM
   Use as solvent for extraction        174

   Organism tested, dose, effect        639

   Products, producers               646
   Applications                    646
   Chemic al name, formula           646
   Physical properties                646
   Major end uses                   646

CHLORO IPC
   Sec CHLORPROPHAM

CHLOROPHENOTKANE
   See DDT

3-(p-CHLOROPHENYL)-
   l.I-DIMETHYLUREA
   Sec MONURON

2-CHLOROPHENYLPHENATE
   Chlorinated phenols               370
   Nasal, bronchial irritation          370

CHLORO-2 PHENYLPHENOL
   Conjunctivitis in apple sorters       368
   Dermatitis, humans               368

CHLOROP1CRIN
   Halogcnated hydrocarbon
    ,  nematocides                  71
   Dowfume MC-33 (mixture of
      methyl dibromide plus
      chloropicrin)                  71
   Chlorinated aliphalics             367
   Eye irritation                    367

   Chlorinated aliphatics             369

   Respiratory irritation             370
   Use as nematocide                370

6-CHLOROPIPERONYL
   CHRYSANTHEMUMATE
   See BARTHR1N

CHLOROPROPYLATE
   Organochlorincs                 63
   Compounds related to DDT        63
   Use rates as insecticides            63
   Use rates as miticidcs             63

2-CHLOROTRIETHYL AMINE
   Mutations in higher plants          583

   Mutations                       585

CHLOROXURON
   Substituted urea.,                 69
   Herbicides                      69
   Persistence in soil                 69
   Use rates                       69
   Toxicity to warm-blooded animals   69
   Toxicity to fish                  69

   Ureas                          608
   May affect DNA                 608

CHLORPROMAZINE
   Effect on cortical activating
      system                       418
   Effect on attention test            418

   Induction of microsomal enzymes   528

CHLORPROPHAM
   Carbamates                     69
   Use in agriculture                 69
   Use rates                       69

   Persistence in soil                 70
   Toxicity to humans               70
   Toxicity to warm-blooded animals   70

   Judged not positive, tumor
      inducuon                    469
   Registered for use on food crops     469

   Tumorigenicity testing, rating       490

   Tumorigenicity testing, rating       491
                                                                         13

-------
                          CHEMICAL SUBSIANCfi INDEX
   Products, producers               646
   Application                      646
   Chemical name, structure          646
   Physical properties                646
   Product forms                    646
   Oral toxicity, LD-50               646
   Major end uses                    646

   No significant increase in
      anomalies                     674

CHLORTHION
   Acute oral toxicity. LD-50          312
   Acute dermal toxicity, LD-50       312

   Aerosolization of, cutaneous
      contamination                 445

   Inhibition of hepatic metabolism
      ofdcsoxycorticosterone         533
CIODRIN
   New pesticides                    59
   Use in control of flics              59

   Organophosphatcs, phcnyl
      derivatives                     64
   Use rates                        64

   Urine, indicator of exposure        448

CIPC
   See CHLORPROPHAM

CLOBBER
   Sec CYPROMID

CLOROX
   Inorganic fungicides               66
   Use in agriculture                 66
   Use rates                        66

COAL TAR
   Fungicides                       202
   Wood preservatives                202

COLCHICINE
   Mutations in higher plants          583

   Pretreatment, cell studies           593

   Effect on spindle formation         604

COMPOUND 1080
   Development by U.S. Fish and
      Wildlife Service                45
   Use as rodcnticide                 45
    Fluoride rodenticides              72
    Toxicity to warm-blooded animals   72
    Properties                        72

    Rodenticides                     214
    Toxicity to man                   214
    Toxicity to domestic animals        214

    Production of ventricular
      fibrillation                     371
    Production of cardiac arrest         371
    Death from                       371

CONTRATH1ON
    Antagonize muscle paralysis of
      cholincsterase inhibitors         453


COPPER
    Salts of, use as pesticides            45

   Inorganic fungicides                66
   Metal organic fungicides             66
   Uses                              66
   Use rates                         66

   Contained in fungicides            202

   Sulfatc, U.S. pesticide
      production, annual             315

   Sulfatc, U.S. pesticide
      pioduction, 1966               382

   Poisoning, treatment of            451

   8-hydroxyquinolinc, tumorigcn-
      fcity testing, results             475

COPPER DfTHIOCARBAMATE
   Tumorigenicity testing, rating       491

COPPER 8-
   HYDROXYQUINOLINE
   Tumorigenicity testing, priority
      testing                        475
   Registered but not for use on
      food crops                    475

COPPER NAPHTHENATE
   Metal organic fungicides             66
   Used in treatment of handling,
      harvesting and storage
      equipment                     66
   Use rites                         66
   Used to prevent rot and mildew      66
 14

-------
                         CHEMICAL SUBSTANCE INDEX
COPPER OXID3
   Inorganic fungicides              66
   Uses                           66
   Use rates                       66

COPPER OXIr'ATE
   Metal organic fungicides           66
   Uses                           66
   Use rates                       66

COPPER SULFATE
   Inorganic fungicides              66
   Uses                           66
   Use rates                       66

   U.S. pesticide production, annual    315

   U.S. pesticide production. 1966     382

COPPER ZINCCHROMATE
   Inorganic fungicides               66
   Uses                           66
   Use rates                        66

CORAL
   Organophosphates                64
   Use in agriculture                 64
   Use rates                        64

   Acute oral toxicity, LD-50         31 ?.
   Acute derm.J toxicity. LD-50       312

COTORAN
   See FLUOMETURON

COUMAFURYI.
   See FUMARIN

COUMAPHENE
   See WARFARIN

COUMAPHOS
   SeeCO-RAL

COUMARIN     /
   Food Additive                    583
   Chromosome aberrations in
      higher plants                  583

CREOSOTE
   Pesticides before 1945             44
   Introduction as insecticide
      in 18th century                44

   Miscellaneous insecticides          65
   Used to prevent termite damage     65

   Miscellaneous fungicides           67
   Uses                           67
   Use rates                        67
    Wood preservative                202

    Toxicity to non-target organisms    203

 CRYOLITE
    So: SODIUM
    FLUOALUMINATE

 CUELURE
    Synthetic insect attractants        75
    Use to control flies               75

 CYANAMIDE
   Tumorigenicity testing, priority
      for testing                    473
   Registered but not for use on
      food crops                    473

 CYANIDE
   Hydrogen cyanide, development of
      resistence to                  45

   Fumigants, hydrogen cyanide       65
   Use rates                        65

   Inorganic rodcntirides             71

   Calcium cyanide                  72
   Sodium fluorosilicate plus
      zinc cyanide                  72

   Toxicity                        €05
   Mutagenic study                  60S

   Hydrogen cyanide, products,
      producers                     649
   Application                     649
   Chemical name, formula           649
   Physical properties                649
   Oral toxicity, LD-50               649
   Major end uses                   649

CYCASIN
   Plant toxin                      594
   Formation of muUfenic
      metabolic products from        594

CYCLOHEXIM1DE
   Use rates                        66
   Use as fungicides                  66

CYCOCEL
   Growth retardants                74

CYGON
   See DMETHOATE

CYOLANE
   Organophosphates                608
   May affect DNA                  608
                                                                            IS

-------
                    CHEMICAL SUBSTANCE IKDEX
CYPREX
See DOOINE
CYPROMID
Amide derivatives
Preemcrgent herbicides
Persistence in soil
Use rates
Toxicity

CYTOSINE ARABINOSIDE
Chromosome aberrations in
higher plants

Chromosome aberrations in
mammalian cells, tissue culture
•TYTROL
Mutagenic in plants

?.4-D
Needed knowledge of sample
composition, purity

Introduction in 1930's

Phenoxy herbicides
Uses
Toxic
-------
                         CHEMICAL SUBSTANCE INDEX
2.4-D BUTOXY ETHANCL
   ESTER
   Amount applied in reservoir areas   126
   Herbicide                       126
   Toxicity to aquatic fauna          126
   Toxicity to mosquito larvae        126
   Determination 10 months after
      treatment with 2,4-D           126

2.4-D BUTYL ESTER
   Tumorigcnicity testing,
      judged not positive             475
   Registered for use on food crops    475

   Testing for increase anomalies      673

2.4- D ETHYL £STER
   Testing for increase anomalies      673

2.4-D ISOOCTYL ESTER
   Tumorigcnicity testing, results      475
   Registered for use on food crops    475

   Production ov* abnormal fetuses
      in litters                     666

   Testing for increase anomalies      673

2,4-D ISOPROPYL ESTER
   Tumorigenicity testing, results      474
   Registered for use on food crops    474

   Production of abnormal fetuses
      in liners                     666

   Testing for increase anomalies      673

2,4-D METHYL ESTER
   Testing for increase anomalies      673

DACONIL 2787
   Chlorine-containing fungicides      67
   Uses                           67
   Use rates                        67

DACTHAL
   Phthalic acid herbicides           68
   Preemergence compounds         68
   Persistence in soil                68
   Toxicity to mammals             68
   Use rates                        68

DALAPON
   SeeDOWPON

DCNA
   See DICHLORAN
 DCPA
   See DACTHAL

 DCU
   Ureas                           608
   May affect DNA                  608

 DDA
   Concentration in urine, excreta,
      monkeys, human.-              268
   Relation to DDT intke            263

   Concentration of DDA in excreta.
      monkey, vs daily dose DDT     289

   p,p'-DDA in urne, humans, vs
      time of treatment with
      p,p'-DDT                     290

   Concentration of p.p'-DDA in
      urine, humans, vs
      concentration of p,p'-DDT
      in body fat                    291

   Ingcstion of DDT, excretion of
      metabolite, humans, effect       298

   Urinary excretion, humans          299

   Principal metabolite of DDT        388
   Concentration in urine,
      indicator of exposure            388

   Excretion of in urine,
      monkeys, humans             427

p.p'-DDA
   Concentration in urine, humans,
      treatment with p,p'-DDT        290

   Concentration in urine, humans,
      vs concentration of p,p'-DDT
      in fat                        291

DDD
   Uses, restricted to use for
      which no alternative available     8

   Concentration in lakes              119

   Applied to lake for gnat control     126

   Water concentrations              128

   Examination of estuaries            129

   Ren- ues in cow's milk              140
                                                                             17

-------
                          CHEMICAL SUBSTANCE INDEX
   Persistent chlorinated
      hydrocarbons                  180
   Decrease usage over next 2 years     180

   Nerve poison in insects             189

   Effect on reproduction in birds      212

   Studies in volunteers               296

   Experimental oral exposure         300

   Acute oral toxicity. LD-50          313

   Concentration in human milk        449

   Eliminate use in food production     472

   Effect on dieldrin storage            S27

o.o'-DDD
   Tumorigenicity testing, rating        489

o,p'-DDD
   Attophy of adrenals in dogs         300

   Effect on adrenals in man           301
   Signs and symptoms, humans        301

   Taatogenicity testing, rating        489

   Testing for increase anomalies        673

p,p'-DDD
   Residues of, human adipose tissue    269

   Teratogenicity testing, results        473
   Registered for use on food crops     473

   Residues in human tissues           S2S

   Testing for increase anomalies        674

DDE
   Metabolite of DDT                  9
   Distribution in environment          9

   In blood, long term exposure        33

   Atmospheric contamination         113
   Transport by storms                113

   Concentration in lakes              119
   Water concentrations               128

   Examination of estuaries            129

   Dietary intake. FAO-WHO          137
Residues ii. cow's milk             140

Blood leveU, hunrms               148

Action as nerve poison in insects     189
Effect in buds, on reproduction     189

Contained in fish                  209

Effect on reproduction in birds      212

In blood, long term exposure        232

In human tissues                  245

Paper chromatography of           257

Blood and adipose residues.
   human.-.                       321

Occupational differences,
   residue; in                     322

Age relationship, residues           323

Residues, Iskimo adipose tissues     326

Concentration in home
   environments                  327

Residues, levels and disease          328

In blood, c'tildren                  336

In adipose, humans, by age
   and race                       337

Storage, in comparison with
   DDT. volunteers                349

Levels, association with age          357 ~'

Annual intake                     384

Dietary intake                     385

In tissues, humans                 386

Conversion of DDT to DDE
   by man, rats                   424

Conversion of DDT,
   various rpecies                 427

Influence of sex hormones
   on storage, rats                 428

Conversion of DDT in humans      429
18

-------
                          CHEMICAL SUBSTANCE INDEX
   Storage of. r.ts, infestation
      with Trichina                   430

   Blood levels of, effect on
      patients taking phenobaibital
      and dilar.tin                    436

   In blood, humans, occupational
      groups, whites vs non-whites      449

   Effect on dkldrin storage           527

   Effect of aldrin administration,
      dogs, humans                   528

   In blood, humans                  529

   In adipose tissues, humans,
      exposure to household
      pesticides                      537

   In adipose ussue,
      occupational exposure           538

   Converaor of DDT to DDE by
      houseflys, effect of MDP
      compounds en                  559

   Transplacental passage of
      DDT and DDE, humans          675

pj'DDE
   Residues of in human
      adipose tissue                   269

   In adipose, humans                340

   In adipose, humans                341

   Residues, humans                  525

DDMU
   Effect on c'ieldrin storage           527

DDT
   Eliminator of use of DDT within
      two years, conditions            8

   Distribution in man, animals,
      environment                    9
   Use in developing nations           9
   Persistence                        9

   Environmental contamination        12
   Development of standards           12

   DDT contamination lakes, rivers      13
   In Coho salmon                    13
 Contained in foods                 14
 Effect of Delaney clause            14

 Distribution in global
   environment                    19

 Use in domestic pest
   control programs                21
 Use in malarial control
   programs                      21

 Persistence                        25
 Effect on reproduction, survival
   of nontarget species             25
 Effect on egg shells in
   ducks, falcons                  25

 Use reduction during next 2 years    26

 In blood, relation to
   recent exposure                 33

 Safety, acute intoxication           34
 In general population, effects        34

 Industrial exposure                 35
 Need for limit in blood              35
 Human residues, donates            35

 Enzyme induction, liver             36

 Use in domestic pest
   control programs                43
 Use in malarial control programs      43

 Insecticidal properties.
   discovery of in 1939             44

 Insecticidal properties,
   Switzerland. 1939                45
 Military use of. World War II         45
 Use of, typhus epidemic             45

 Use of after 1945                   46
 Resistance to                      46

 Exports in 1967                    47
 Usage in agriculture, survey          47

Usage of in agriculture. 1966         48
Production, exports                 48
Usage                             48
Uses                              48

Production, exports                 49
Use in malarial programs            49
Persistence                         49
                                                                                19

-------
                    CHEMICAL SUBSTANCE INDEX
" J'ety to nan
Banning of use in U.S.

Methoxychlor usag:,
comparison with DDT

Uses, commercial pest
control operators

Foreign, countries.
insecticide uses
Resistance in housefly,
1946, Sweden

Gypsy moth control, replacement
of DDT by Sevin (carbaryl)
Mosquito larvae control.
replacement of DDT by Abate
Most wide!;- un,^ organochlorine
Reduced incentives for industry
industry *o develop new
compound*
Cost per pound

Cost per pound, 1968
World crop usage of insecticides
Use on fruit, foreign countries

Rice crops
Use of DDT to control pests

Vegetables
Use of DDT to control pests
Potatoes

Use of DDT to control pests
Sugar beet
Use of DDT to control pests

Tobacco
Use of DDT to control pests

Oil seeds
Use of DDT to control pests

Yritow fever and malaria
Use against Aedcs Aegypti
Sleeping sickness
Use of DDT in foreign countries
River blindness

Persistent pesticides
Uses, exports
50
SO


51


54


55

59


60

60
63


79
79

80
S4
84

85
85

87
87
87

88
88
88

89
89

90
90

91
91
91
91
91

104
104
Drift after aerial spraying
Drift of spray and dust
fotirula Jons

Toxicity to budworm
Comparison with Zectran

Drift in storms
Atmospheric contamination

Daily intake, food, air
Water supplied, ground water

Levels in oysters, seasonal
changes

Levels in lakes
In Coho salmon
Fate in aquatic systems
Inhibition of marine
algal photosynthesis
Effect on phytoplankton

Mosquito control
Resistance
Water concentrations

Monitoring of estuaries
Shellfish shampling for
pesticides
Concentrations in river basins

Wheat, residues in

Residues, in diet

Dietary intake

Dietary intake, FAO-WHO

Foods of animal origin '
Sources of residue

Fed to cows, concentration
in milk
Residues in cow's milk
Removal of residues from
tomatoes by canning methods
Removal of residues from potatoes
Residue after storage

Domestic usage, pounds
108

109

111
111

113
113

114
117


118

119
119
120

121
121

127
127
128

129

129
129

133

135

136

137

138
138

• <• n
139
140
141
141
141

147
20

-------
                        CHEMICAL SUBSTANCE INDEX
Use of DDT in homes
Blood levels
148
148
Mothproofing chemicals            ISO
Humin exposure, mothproofing     ISO

Household use                    1S1
Control of mice                   1S1
Control of cockroaches             151

Exposure of workers               1S3
Residues in adipose tissue
   vs general population            153
Accident1;, by industry, by
   occupation
Syndrome in bird poisoning
1S4
Hazard from indoor house spraying
   vs other applications            1SS

Persistence                       179
Effect on reproduction, survival
   of nontarget species             179
Effect on egg shells
   ducks, falcons                  179

Use reduced over next 2 years       180

Persistence                       187
Concentration in food chain        187

Food web, residues of DDT         188

Effect on target, nontarget
   organisms                     189
Mechanism of action in insects      189

Use of, to save trees                195

Mode of death in insects            206

Effect on phytop!ankton            207
Effect on beneficial insects          207

Concentration by molluscs          208

Effect on crabs-                   209
Effect on lake trout                209
Effect on issh reproduction          209

Effect on bird reproduction, in
   companion with DDE           210
Mortality in fsh fry
   and fingerlings                  210
                                 211
 In fat of wild mammals             213
 Composition of commercial DDT    213

 Use of, in U.S.                     221

 In blood, relation to recent
    exposure                       232

 Safety, acute intoxication           233

 Limit in blood, need to establish     234
 Residues in humans                234
                                             Enzyme induction
                                             235
Actions to improve protection
   of public health                239
La filiation of uses essential for
   public health purposes          239

Storage in tissues, humans          245

Effects in humans                 246
Enzyme induction                 246

Use, ease of identification          255
Presence in human adipose tissue    255
Gaps in knowledge regarding
   DDT                          255

Source of error in
   analysis of DDT                257
Polychlorinated biphenyls (PCS)
   in gas chromatographic analysis  257
Concentrations in tissues vs
   level in diet                    264

Duration of exposure vs
   concentrations in tissues         265

Relationship between
   concentrations in various
   tissues                        267
Concentration in tissues vs
   time since exposure ceased       267

Storage in Rhesus monkeys         268

Organochlorines in human adipose   269

Metabolites in excreta              270
            In body fat, comparison with
               HEOD
                                                                              272
Birds, effect of DDT treatment      212
Effects of DDE on reproduction     212
            Results of studies, implications      273

            Storage in rat tissues               27S
                                                                               21

-------
                           CHEMICAL SUBSTANCE INDEX
   Stooge in adipose tissues

   Concentration in body fat vs
      concentrations in diet

   Concentration in fat, humans,
      vs daily dose

   Concentration in fat.
      inale rats, vs diet

   Concentration in fat, monkey,
      with continuing exposure

   Concentration in fat, monkey.
      after exposure terminated

   Concentration in fat, male rats,
      during post-exposure period

   Concentration in excreta,
      monkey, vs daily dost

   Studies in volunteers
   Experimental respratory exposure   296
   Experimental dermal exposure

   Experimental OK! exposure

   Properties of solutions of
   Human exposure, oral, inhalation
   Storage and excretion studies

   Concentration in  fat after
      exposure terminated
   Use, in selected jaundiced
      prtients

   Storage, dynamics of

   Acute oral toxicity, LD-SO
   Acute dermal toxicity. LD-SO

   U.S. pesticide production

   Human pesticide residues

   Studies

   Pathologies, residue of DDT

   Adipose, blood levels of

   Effect of personal variables
      on adipose, blood levels
   Sex differences, effect on DDT
   Ethnic differences, effect
      on DDT
276


277

278


281

282

286


287


289

296
296
296
297
?OQ
4,70
298
299

300
300

302

313
313

315

319

320

321

321


322
322
322
Age differences, effect on DDT
Socio-economic differences.
effect on DDT
Effect of drugs on metabolism of
Place \ viable effect on DDT
OccupationaUy exposed.
residues in
Time variable

Discussion of residue data
Dietary soirees
Non-dietary sources

Secular changes
Levels and disease

Use in treatment of
unconjugatcd bilirubinemia
Occupational exposure, plasma
levels

Effect of age on residues
in adipose
In blood, children
Concentration in adipose.
human, vj age, race
Concentration in adipose, humans.
in U.S. general population
Residues in general population
Morbidity effects of
occupational exposure

Occupational exposure
Concentration in fat of
occupationally exposed vs
general population

Human volunteers

Enzyme induction
Blood level limits
Occupational exposure

Enzyme induction

Effects on th - nervous system
Acute DDT poisoning
Search for chronic DDT
effects
Effects on skin
323

323
323
324

324
324

325
326
327

328
328


329

329


335
336

338

340
341

347

348


348

349

356
356
356

357

359
359

359
363
22

-------
                        CHEMICAL SUBSTANCE INDiJC
 Occupationally related
    skin conditions                 366

 Mixture of chemicals used for
    treating furniture               367
 Monocular retrobubular
    neuritis, mixtures               367

 Effects on cardiovascular system     370

 Henutologic*l disorders            372
 Effects on gastrointestinal tract      372

 Residue in human milk             374
 Ingestion of, by
    breast-fed children              374

 VS. pesticide production, 1966      382

 Occupational exposure             383

 General population exposure        384

 Dietary intake                     385

 In body tissues                    386

 Storage in human fat              387

 Me tabolite DDA in urine           388
 Toxicity studies, rats              388

 Human volunteers                 390

 Occupational exposure            391

 Discussion on exposures           392

 Exposure of popuh 'Ion            393
 Clinical effects, exposures doses     393

 Tissue levels, time trends           394

 Percutaneous penetration,
   route of excretion              402

 In formulation Fekcma ES-30-9     405

 Action in nervous system           408

 Behavioral changes,
   occupational exposure          409
 Effect on locomotion, rats         409

 Effects on nervous system          413

Effects of repeated exposures,
   (Draymen, Baygon              416
Effects on liver, rodents            424

Acute effects on nervous system    425
Effects cf DDT poisoning          425
Effects on liver                   425
Storage in fat                     425

Goats, refractory to DDT
   toxicity                       426
Insects, mammals, differences in
   susceptibility, absorption        426

Fed to rats                        427
Fed to monkeys                   427
Residurs, metabolites              427

Acute oral toxicity, sex effect       428
Storage, sex effect                 428
Effect of sex hormones on
   storage, toxicity               428

Sex dil Terences, storage, humans    429

Interaction of DDT and
   trichinosis, rats                 429

Toxicity, in carbor-tctrachloride
   induced liver damage            430
Ingestion, human                  430
Storage of in persons dying
   of cancer, diseases              430

Mammals, fish, healthy, fat
   effect on DDT poisoning        431
Effect of fat in diet on toxicity      431
Storage, excretion, rats,
   starvation                     431
Exaction of metabolites,
   starvation                     431

Effect on utilization
   of Vitamin A                   432
Effect of temperature on toxicity    432

Temperature, effect on
   performance, rats               433

Histological changes,
   livers, rats                     434
Liver changes                     434

Liver changes, monkeys             435
Effect on adrenal ccitex,
   o,p'DDT isomer                435
Rate of storage, loss               435

Effect on liver enzyme
   system, histology               436
                                                                               23

-------
                          CHEMICAL SUBSTANCE INDEX
   Effect on dieldrin storage           436

   . reatment of unconjugated
      nonhemolytic jaundice           437
   Excretion in human milk            437
   Estrogcnic effect, isomers           437
   Effect on reproduction             437

   Industrial, agricultural exposure      44S

   Excretion of metabolite DDA,
      in urine, humans, occupational
      exposure, volunteers             447

   In blood, whites vs nonwhites,
      occupational groups             449

   Health benefit; vs carcinogenicity
      for man                        463

   Use, benefits                      470
   Carcinogenicity, discussion          471
   Chronic human exposure            471

   Benefits, uses                      472

   Effect of imposing zero tolerance    480

   Chemicals structurally related
      to DDT, carcinogenicity
      raring                         489

   Correlation between exposure and
      tiswc concentration             495

   Enzyme induction                 518

   No-effect dietary level studied        519
   Enzyme induction                 519

   Interaction with other chemicals     521
   Enzyme induction, discussion        521

   Persistent pesticides in tissues        525
   Residues in consumer products       525

   Surface active agents, effect
      on oral toxicity, rats             526

   Simultaneous administration with
      dieldrin, effect on storage        527
   Enzyme induction                 527
   Effect on metabolism of lindane     527
   Effect on metabolism of DDT        527

   Inhibitors of protein synthesis,
      effect on DDT enzyme induction  528
   Aldrin, effect on storage             528
    Phcnobsrbital, use in acute
       DDT poisoning                 529
    Effect of starvation                 529

    Effect of diet, low protein, rats      532

    Factors determining storage         537

    Residues, environmental exposure    538
    Residues, occupational exposure     538
    Residues time of exposure          538
    Residues, after exposure
      terminated
   Bibliography

   Organism tested, dose.
      biological effect

   Products, producer
   Physical properties
   Product forms
   Oral toxicity. LD-50
   Major end uses

   Reproductive effects
539
   Combined effects of DDT.
      pyre thrum and piperonyl
      butoxidc, rat liver               544

   Chemical structure                  556

   Conversion to DDE, houseflics       559

   Not suspected to produce
      genetic mutations               606

   Usage, insecticides                  610
   Use in agriculture                   610

   Use in household formulations       611

   Organization of bibliography,
      MEDLARS or manually
      obtained                       613
635
640

647
647
647
647
647

665
   Study, human reproductive effects  674
   Residues in human placentas        674

   Study maternal blend levels vs
      first trimester spontaneous
      abortion                      675

o.p'-DDT
   Composition in commercial DDT    213
   Estrogenic-iike effect in rats
      and some birds                213
24

-------
                         CHEMICAL SUBSTANCE INDEX
  Concentrations in humans         429

  Atrophy of adrenal gland with
     DDT                        435
  Concentrations of DDT in adrenal
     gland in comparison with
     other tissues                  435
  Effect on adrenal due to o,p'-DDT
     in technical product            435

  Estrogenic effects in rat            437

   Residues in human tissues         525

p,p'-DDT
   Needed knowledge of sample
     composition, purity             11

   Effect of isomers of DDT          213
   Nonestiogcn-likc action in rats,
     birds: unlike o.p'-DDT         213

   Residues in human adipose tissue   269

   Decline of residues after
     exposure terminated           270

   Concentration in fat, humans,
     with continuing intake         283

   Concentration in fat, steers,
     after exposure terminated       288

   Concentration of p,p'-DDA in urine,
     humans, time of treatment with
     p.p'-DDT                    290

   Concentration of p,p'-DDA in
     urine, humans, vs concentration
     ofp4>'-DDTinfat             291

   Human*, concentration in fat       299
   Excretion in urine of DDA         299

   Plasma levels                    300

   Concentration in tissues,
     males vs females               429

   Non-estrogenic activity in rats      437
   Estrogenic effects in-tats
     Welch                        437

   Judged  positive for tumor
     indue Ion                    470
   Registered for use on food crops    470

   Chlorine-containing compounds,
     tutnorigenic                  489
   Tumorigenktty, rating             489

   Residues, human tissues            525

DDVP
   See DICHLORVOS

DEF
   SeeFOLEX
DEFEROXAMISE
   Iron Chdatii.g agent               451

DEHYDROACETIC ACID
   Tumorigenkity testing,
      priority for testing              475
   Registered for use on food crops     475

DEI.NAV
   Acute oral toxkity, Lb-50          312
   Acute dermal toxkity, LD-50       312

DEMETON
   Organophosphorus compounds.
      aliphatic derivatives             64
   Use rates                         64

   Controlled exposure, humans       296

   Acute oral ioxkity, LD-50          312
   Acute denral toxicity, LD-50       312

   Occupational exposure,
      health effects                  345

   Effects, exposure                  364

   Occupational!/ related
      skin conditions                 366

   Handling, precautions for use       444

   Organophosphates                 608
   May affect DNA            '       608

   Methyl-demeton, systemic
      insecticide                    610

DEMOSAN
   Chlorine-containing fungicides       67
   Uses                            67
   Use rates                         67

DEOXYADENOSINE
   Chromosome aberrations
      in higher plants                 583

   Chromosome aberrations           591
                                                                               25

-------
                          CHEMICAL SUBSTANCE INDEX
                                    67
                                    67
                                    67
                                    67

                                   608
                                   608
                                   608
                                   413

                                   418
DEXON
   Miscellaneous fungicides
   Used in agriculture
   Uses
   Use rale

   May affect DNA
   Mutagenicity, possible
   Diazo compound

DFP
   Reactivation of florid
      psychotic attacks

   Reactivation of psychosis

DIALLATE
   See AVADEX
 2.6-D1AMINOPURINE
    Chromosome aberrations
      in plants                     591
    Chromosome aberrations in
      mammalian tissue culture cells   S91
    Mutagenic effects                 S91

 D1AZINON
    Replacement for chlordanc          S3
    Pest resistance to                  53

    Organo-phosphate                 64
    Use rate in agriculture              64

    Organic phosphate                 71
    Use rate                          71
    Insecticides, nemaiocide            71

    Grasshopper (Turura) control in
      Argentina                     91
    Animals, precaution with           91

    Household use                    151
    Cockroach control                151
    Persistence                      IS I
    Used with DOVP                 1S1

    Epidemics of poisoning by         310

'    Acute oral toxicity. LD-50         312
    Acute dermal toxicity. LD-50       312

 DIBROM
    See NALED

 DIBROMOCHLOROPANE
    SecNEMAGON

 DIBUTYL SUCCINATE
    Insect repellent                    75
 D.'CAMBA
    Benzoic acid compound            68
    Herbicide                        68
    Persistence in soil                  68
    Toxicity to mammals               68
    Use in agriculture                  68

    Mutations in barley               584

    Use in agriculture                 610
    Herbicide                       610

    Products, producers               647
    Application                      647
    U.S. patent number               647
    Chemical name, structure          647
    Physical properties                647
    Product forms                    647
    Oral  toxicity. LD-SO               647
    Major end uses                    647

 DiCHLOBENIL
    SeeCASORON

DICHLONE
   Chlorine containing fungicides      67
   Use in agriculture                  67
   Use rate                         67

   Tumorigcnicity  testing, results      475
   Registered for use on food crops     475

   Tumorigenicrty  testing, rating       490

DICHLORAN
   Chlorine containing fungicides      67
   Use in agriculture                  67
   Use rates                         67

   2,6-DichJoro-4-nitroanilinc.
      active ingredient in
      formulation, Botran            473
   Tumorigenicity testing              473

   Tumorigenicity testing,
      judged not positive              475
   Registered for use on food crops     475
   Compare with
      2,6-dichloro-4-nitroaniline       475

   Tumorigenicity testing, rating       490

   Tumorigenicity testing, results      492
   Amines and anilides                492

   Mutations in barley                584

   Organism tested, dose, effects       640
 26

-------
                         CHEMICAL SUBSTANCE INDEX
   Products, producers               647
   Application                      647
   Chemical i.ame, structure          647
   Physical properties                647
   Product forms                   647
   Oral toxicity. LD-30              647
   Major end uses                   647

3.6-DICHLORO-O-ANISIC
   ACID
   See DICAMBA

p-DICHLOROBENZENE
   See PARADICHLOROBENZENE

DICHLOROETHANE
   Occupational exposure,
      health effects                 345

   Effects on UNA. possible          606

2.6-DICHLOR&4-
   NITROANIL1NE
   Sec DICHLORAN

2.4-DICHLOKOPHENOXY-
   ACETIC ACID
   See 2,4-D

a-<2,4-DICHLOROPHENOXY)
   PROPIONICACID
   Tumorigenicity testing, results      474
   Registered for use on food crops     474

DICHLOROPKOP
   Phenoxy herbicides               68
   Use                            68
   Systemic herbicide                68
   Persistence                      68
   Toxicity to man                  68
   Toxicity to animals               68
   Use rate                         68

DICHLOROPROPANE
   NcmatocMes, halogenated
      hydrocarbon                  71
   Persistence, residual activity        71
   Toxicity to humans               71
   Used with dkhloropropenc         71
   Toxicity to plants                71
   Use rate                         71

   Pest control, nematocides          198
   Application methods              198
   Toxicity to non-target organisms    198
   Fumigant                       198
DICHLOROPROPENE
   Nematocide, halogenated
      hydrocarbon                  71
   Persistence                      71
   Residual activity                  71
   Toxicity to humans               71
   Toxicity to plants                71
   Application methods              71
   Used with dichloropropane         71
   Use rate                 .       71

   Nematocide                     198
   Pest control                     198
   Toxicity to non-target organisms    198
   Application methods              198
   Fumigant                        198

   Chlorinated aliphatic nematocide    367
   Eye irritation                    367
   Fumigant                        3*/
   Use in agriculture                 367

   Respiratory irritation              370

2,2-DICHLOROVlNYJ.
   DIMETHYL PHOSi HATE
   See DICHLORVOS

DICHtORVOS
   Fly control for livestock           59
   Fly control for dairy barns         59
   Organophosphate                 59

   Organaphosphorous compound      64
   Use rate                        64

   Quantities used, domestic          147

   Insecticides, household use         151
   Used with diazinon and chlordane    151

   Acute oral toxicity, LD-50         312
   Acute dermal toxicity, LD-50       312

   Dermatitis, contact, allergic         364

   Mutagenicity in higher plants        576

   Chromosome aberrations in
      nigher plants                   583

   Household use                    611

   Effects on onion chromosomes      640
   Producers                        f*l
   Application                      647
                                                                            27

-------
                          CHEMICAL SUBSTANCE INDEX
   Patent number
   Chemical name, structure
   Physical properties
   Product form
   Oral toxicity, LD-50
   Major end uses

DICOFOL
   See KELTHANE

DICROTOPHOS
   See BIDRIN

DICRYL
   Herbicides, pre-emergent
   Persistence
   Toxicity
   Use rate
   Herbicides, amides
   Use in agriculture
   Use in home and garden

   Tumorigenkity testing, results
   Registered but not for use
      on food crops

   Tumorigericity testing, rating

   Tumorigenicity testing, results

   Testing for increase anomalies

DIELDR1N
   Persistence
   Environmental contamination

   Needed knowledge of sample
      composition, purity

   Persistence
   Decrease usage over next 2 years

   Blood levels, measure of exposure

   Toxicity, poisoning

   Controlled human studies, results

   Uses, usage

   Use for termite control

   Use, insect control

   Usage, foreign countries

   Replacement by, of new soil
      insecticides
647
647
647
647
647
647





70
70
70
70
70
70
73
475

475

490

492
674

9
9

11

26
26
33
34
35
52
53

54
55

60
Chlorirated aryl hydrocarbons
Use

Effect of DDT upon storage of

Usage, .vorid crops
Cereal (.rops
Seed dressings, use to
control pests
Sugarcane crops
Use to control pests
Control of pests, resistant
to other pesticides

Locusts
Use to control insects
Termites
Use to control pests
Yellow fever and malaria
Use to control pests
{Tiaras disease
**••• 'Ufm * ' • '
Use to control pests
Sleeping sickness
Use to control pests
Grasshopper control
Persistence
Air transport of. analysis
in air

Atmospheric contamination
Ground waters
Transport through soil

Water samples, analysis
Potable water supply
Standards, limits
Concentrations in rice paddies
Water concentrations, analysis
Most frequently found pesticide
Examination of estuaries.
shellfish
Cucumbers grown on treated
soil, residues in
Residues in seed crops
63
63

81

84
85

86
89
89

89

90
90
90
90
91
91
91
91
91
91
91
104

113

114
116
116

117
121
122
125
128
129

129

132
133
28

-------
                         CHEMICAL SUBSTANCE INDEX
 Dietary intake                     136

 Acceptable daL'y intake. FAO-WHO  137

 Foods of aninuJ origin, source
   of pesticides                   138
 Intake, human t                    138

 Residues in cow's milk              140

 In runoff water                    145
 Leaching of pesticides from
   soil by water                   14S

 Occupational exposure, workers,
   health hazard                   155

 Persistence                        180
 Decrease usage over next 2 years     180

 Deaths to wildlife                  200

 Effect on phytoplankton            207

 In marine invertebrates              208

 Mortality in crabs, feeding upon
   fish killed by dieldrin            209

 Effect on marine life                210
 Fish kills                         210

 Bird poisoning                     211

 Exposure of biids to                212

 Effect on mammals, occasional
   mass mortalities                 213

 Blood levels, measure of c xposure    232

Toxicity, poisonings                233
Controlled human exposure         233

Actions to improve protection
   of public health                 239
 No extension of present uses         239

Concentrations of residues in
   tissues, rats, dogs               265

Concentrations in tissues           266

Concentrations of HEOD in blood
   and other tissues, rats, dogs      267

Exposure of workmen, HEOD in
   blood                         268
 Concentration in body fat of
    animals vs concentration
    indict                         280

 Studies in human volunteers         296

 Experimental oral exposure         301

 Concentration in adipose tissue      302
 Estimated half-life, blood,
    humans                        302

 Epidemics of poisoning             310

 Acute oral toxicity, LD-50          313
 Acute dermal toxicity, LD-50        313

 U.S. pesticide production, annual    315

 Adipose residues                   ."71

 Personal variables, effect on         322
 Sex differences, effect on            322

 Age differences, effect on            323

 Place variables, effect on            324

 Secular changes, effect on           328

 Comparison of human adipose
    residues, DDT, dicSdrin           338

 Comparison of human adipose
    residues, DDT, dieldrin           339

 Adipose residues, human            340

 Adipose residues, human            341

 Occupational exposure, humans      349

 Occupational exposure, humans      351

Occupational!/ related skin
   conditions                     366

Bilateral retrobulbar ni-uritis
   from mixture of chemicals       368

In human milk                    374

U.S. pesticide production           382

Occupational exposure, humans,
   residues in fat                  383

In autopsy tissue                  386
                                                                               29

-------
                          CHEMICAL St'BST . NCE INDEX
  Excretion of, residues of           388

  Time trends of hazard              395

  Penetration of                    403

  Sample skin matrix                405

  Occupational exposure, results       409

  Behavioral effects                  413

  Oral toxicity, rats, age effects       427

  Concentrations in adipose tissue,
     males vs females, humans        429

  Dermal exposure, partially
     hepatcctomized rats, toxicity     430

  Nutrition, starvation, effect
     on toxicity                    431

  Dietary protein, effect on
     toxicity                       432

  Rats, effect on liver, duration
     of exposure                    43S
  Liver changes, rats                 435

  Excretion in urine, occupationally
     exposed vs general population    447

  Occupational exposure, analysis
     of blood                      448

  Tumorigenicity testing, results       470
  Registered for use on food crops     470

  Enzyme induction studies in
     progress                       520

  Residues in consumer products      525

  Storage, interaction of DDT.
     dieldrin                       527

  Effect of chemicals on
     dieldrin storage                528

  Treatment of cows exposed to
     aldrin-contaminated feed,
     effect on dieldrin               529

  Effect of surgical stress,
     starvation on blood levels        530
  Vitamin-A deficient rats.
     effect on storage               530
   Diet, effect on                    532

   Measurement in blood, body
      burden of                     537
   Total daily intake                 537

   Occupational exposure, blood
      levels, vs general population      538
   H'jman volunteers, results          538

   Effect of termination of exposure    539

   Metabolism of                    559

   Effect on DNA                    606

   Organism tested, dose, effect        640

   Products, producers                648
   Application                       648
   U.S. patent number                648
   Chemical name, formula            648
   Physical properties                 648
   Product forms                     648
   Oral toxicity, LD-50               648
   Major end-uses                    648

   Embryotoxicity in rats, dogs        664

   Flacental transfer of                665
   Study of stillbirths in cows          665

DIEPOXYBUTANE
   Mutations in higher plants          583
   Epoxidcs                         583

   Mutations in neurospora            585
   Mutations                         585
   Chromosome aberrations in olants    591
   Chromosome aberrations in
      mammalian tissue culture cells    591
   Mutagcnic effect                   591
BIS (DIEThYLCARBAMOYL)
   D1SULFIDE
   DITHIOCARBAMATES
   Tumorigenicity testing, rating
DIETHYL FUMARATE
   Dermatitis

   Intermediate product of malalhion
   Scnsitization in humans

0.0-DIETHYL o.p-NFTRO-
   PHENYL PHOSPHORO-
   THIOATE
   See PARATHION
491
364

399
399
30

-------
                        CHEMICAL SUBSTANCE INDEX
DIETHYLNTTROSAMINE
   Carcinogen                     261

DIETHYL 1,3-PROPANE-
   DISULFCNATE
   Mutations in higher plants         584

DIETHYLST1LBESTROL
   Effect on DDT storage in rats      428
   Cnzyme activity, rats             428

DIETHYL SULFATE
   Mutations in higher plants         583

   Mutations in barley              585
   Mutations in neurospora           585
   Mutations                      585

DIETHYLSUCCINATE
   Inhibition of aliesterase enzymes
     by organophosphates          513

   Human blood aliesterase activity
     for substrates                514

DIETHYLTOLUAMIDE
   Insect repellent                  75

   Insect repellent                 611
   Recommended for mutagenic
     evaluation                   611

D1FOLATAN
   Teratogenic activity, chick
     embryo                     438

U-DIHYDRO-3,6-
   PYRIDAZINEDIONE
   See MALEIC HYDRAZIDE

DIHYDROSAFROLE
   Use in preparation ot
      piperonyl butoxide            541

   Cancer of the esophagos, rats       543

   Liver tumon in mice              544

   Thin layer cinematography of
      metabolites of               547
   In rat bile, urine                 547

   Metabolism                     548
   Major metabolic pathway, in mice   548

DDSOPROPYL
   FLUROPHOSPHATE
   SeeDFP
DILANTIN
   See DIPHENYLHYDANTOIN

DIMECRON
   See PHOSPHAM1DON

DIMEFOX
   Oiganophosphoms < ompound      444
   Precautions for application        444

   Organophosphorus compound      608
   May affect DNA                 608

DIMERCAPROL
   SecBAL

D1METHOATE
   Oiganophosphorous compounds    64
   Use rate                       64

   Grasshopper control              91

   Poor or lack of grasshopper
      control                     92

   Action of EPN upon degradation of  513

   Degradation of human liver        514
   Amidase activity, humans, animals   514

   May affect DNA                 608
   Organophosphate                608
   Systemic insecticide              610
   Use in agriculture                610

DIMETHRIN
   Botanical insecticide              63

DIMETHYLAMMONIUM
   DITH1OCARBAMATE
   Tumorigenicity testing, rating      491

BIS (DIMETHYLCARBAMOYL)
   DISULFIDE
   DITHIOCARBAMATE
   Tumorigenicity testing, rating      491
DrMETHYLNlTROSAMINE
   Carcinogenic studies, mice
484
   Formation of mutagenic metabolic
     products from                594

DIMETHYLSULFOXIDE
   SeeDMSO
DIMETILAN
   Chemical structure
                                                                       557
                                                                        31

-------
                          CHEMICAL SUBSTANCE INDEX
   Effects on DNA, Possible           607
   Carbamates and thiocaibamates     607

DIMITE
   Compound related to DDT         63
   Uses                            63
   Use rate                         63

DINITROBUTYLPHENOL
   Miscellaneous insecticide           65
   Limited use in agriculture           65
   Use rate                         65

DINITROCRESOL
   Miscellaneous insecticides           65
   Use in control of termites           65
   Use rate                         65
   Nitrophenol compounds            65

   Skin staining                      370
   Nitrophenois                      370
   Fatal cases                       370

DINITROPHENOL
   Dinitrophcnols, use in Germany     45

   2,4-dinrtrophenol. use in
      treatment of obeaty            368
   Nitrophenois                      368
   Cataract development in U.S.        368

   Nitrophenois                      370
   Respiratory iiritation              370
   Skin staining                      370

   Treatment for poisoning, humans    450

   Inhibition of oxidattve
      phosphorybtion               604

DINITRO-O-PHENOL
   Toxicity to rats, effect
      of temperature                 433

2,4. DINITROPHENOL
   Oral agent, treatment of obesity     368
   Cataracts from                    368

2-SEC.-BUTYL-4.6-
   DIMTROPHENOL
   Tumongenicity testing, results       475
   Registered but not for use on
      food crops                    475

DINOCAP
   See KARATHANE
DINOSEB
   Substituted phenolic nerbicides      69
   Uses                             69
   Persistence in soil                  69
   Non-transloiation in plants          69
   Toxicity to mammals               69

   Herbicides                       203
   Hazard:- to non-target organisms     203
   Toxicity to aquatic animals         203
   Toxicity to terrestial animals        203
   Degradation                      203
   Contamination of lakes, streams     203

   Toxicity to non-target organisms    205
   Plant growth regulators            205
   Toxicit/to fish                   205
   Degradation of                   205
   Precautions, water contamination    205

DIPHACIN
   Anticoagulant rodenticides          72
   Properties                        72
   Action                           72
   Symptoms of death                 72
   Precai tions for use                 72

DIPHACINONE
   See DI?HACIN

DIPHENAMID
   Amide:                           70
   Herbicide                         70
   Uses                             70
   Persistence in sofl                  70
   Use rates                          70
   Toxicity                          70

DIPHENATRILE
   Tumongenicity testing, results       475
   Registered but not for use on
      food crops                    475

DIPHENYL
   Miscellaneous fungicides            67
   Uses                            67
   Use rate                         67

DIPHENYLHYDANTOIN
   Effect on residues of DDT
      and metabolites, humans         323

   Effect on DDE blood
      levels, humans                 436

   Use in controlling convulsions       451
32

-------
                          CHEMICAL SUBSTANCE INDEX
   Effect on DDE blood levels         529

DIPTEREX
   Acute oral toxicity, LD-SO         312
   Acute dermal toxicity. LD-SO       312

DIQUAT
   Herbicides                       70
   Mammalian toxicity               70
   Use in agriculture                 70
   Use in industry                   70

   Herbicide, aquatic                 205
   Toxicity to fish, wildlife           205

   Nitrogen compounds              365
   Effects on skin and nails, humans    365

   Effects of paraquat/diquat
      mixtuii in humans             368
   Effects on eye, human             368

   Effects on fingernails              405
   Mechanisrt of action, possible       405

   Effects on DNA, possible           607
   Bipyridiu n quaternary salts         607
   Effects or, plants                  607

DISODIUM METHANE
   ARSONATE
   Metal organic compounds          68
   Uses                            68

DISULFOTON
   Plant systemic insecticides          60
   Replacement for aldrin, dkldrin     60

   Organophosphorus compounds      364
   Cholinesterase inhibitors           364
   Effects                          364

   Systemic insecticide               610
   Use in agriculture                 610

Di-SYSTON
   Acute otal toxicity, LD-SO         312
   Acute dermal toxicity LD-SO       312
   Phosphate ester pesticide           312

DITHANE Z-78
   SeeZINEB

DfTRANIL
   See DICHLORAN
 DIURON
    Substituted ureas                  69
    Absorption plant through roots      69
    Persistence                        69

    Tumorigenicity testing, results      475
    Registered for use on food crops    475

    Tumorigenicity testing, rating       490

    Ureas                            492
    Tumorigenicity testing             492

    May affect DNA                   608

    Testing for increase anomalies       673

 D1ZANE
    Diphenyl aliphatic chlorinated
      hydrocarbons                  63
    Compounds related to DDT         63
    Use rates                         63
    Uses                             63

 DMBA
    Persistence in mice, age groups       484

DMSO
   Effect on percutaneous
      penetration of Seman           403 .,
   Effect on potency ratio of Seman   403
   Effect on LD-SO                  403

   Effect on spontaneous
      motor activity .rats             417
   Effect on hexobarbital
      steeping time, rats              417
   Effect on conditioned avoidance
      response, rats                  417

   Solvent for 2,4,5-T studies         666

   Effect on Utters, mice             667
   Effect on fetal abnormalities        667

   Solvent for increase
      abnormality testing             670

DNOC
   Toxicity to rats,
      effect of temperature           433

   Urine, indicator of exposure        448
   Method, blood analysis             448

DNPB
   SeeDINOSEB
                                                                              33

-------
                          CHEMICAL SUBSTANCE INDEX
 DODINE
    Fungicides, niiscellaneous
      group                        67
    Uses                            67
    Use rates                        67

    Tumorigenicity testing, judged
      not positive                   475
    Registered for use on ibod crops     475

    U.S. sales, use in agriculture         610
    Fungicide                       610

 DOWCIDE A
    Miscellaneous fungicides            67
    Uses                            67
    Use rates                        67

 DOWCIDE-7
    Tumorigenicity testing, results      475
    Registered but not for uje
      on food crops                  475
    Use in food containers
      and packaging materials         475
 DOWFUME MC-33
    Halogenalcd hydrocarbon
      nematocides                   71
    Persistence                       71
   Toxic:ty to plants                 71
   Toxicity to humans                71
   Mixtures of compounds            71
   Application rates                  71

 DCWPON
   Aliphatic acid herbicides            69
   Toxicity to broad leaf plants         69
   Toxicity to grass                  69
   Use rates                         69
   Use in agriculture                  69
   Use as soil sterilants                69
   Toxicity to humans                69
   Toxicity to warm-blooded animals   _ 69

 2-(2.4-DP)
   Tumoiigenicity testing, results      474
   Registered for use on food crops     474

 DURSBAN
   Organophosphates                 64
   Heterocyclic derivatives            64
   Use in agriculture                  64
   Use rate                         64

   Use in mosquito control            127

 DU-TER
   Kstal organic fungicides            66
   Uses                            66
    Use rules                         *6

 DYBAR
    See FENURON

 DYLOX
    See TRICHLORFON

 DYM1D
    See DiPHENAMID

 DYREN>-
    Chlorine containing fungicides      67
    Uses                            67
    Use rates                        67

 E-605
    See PARATHION

 ECHOTHIOPHATE IODIDE
    Use in glaucoma                  412
    Effect on human red blood
      cell cholir.esterase              412
    Symptoms in humans              412

 EDTA
    Use in heavy metal poisoning        452
    Routes of administration           452
   delation of copper, lead,
      manganese, mercury and zinc     452
   Mechanism of action               452

 ELCIDE
   May sffect DNA                  60S
   Mercurial                        608

 EMBUTOX E
   Mutation! in barley                584

 EMMI
   Organic mercury compounds        66
   Use as fungicides for
      «ed treatment                 66
   Use a fungicides for bulb
      and corm treatment             66
   Use in agriculture     -            66
   Use rates                         66

   Mercurials                       608
   May affect DNA                  608

 ENDOSULFAN
   Tumorigenicity testing,; .suits       475
   Registered for use on fc id crops     475

   Tumorigenicity testing, rating        490

ENDOTHALL
   Phthalic acid compounds           68
34

-------
                            CHEMICAL SUBSTANCE INDEX
   Herbicides, preerr.ergence
   Persistence in soil
   Toxicity-to mammals
   Use in agriculture
   Use rates

   Organism tested, dose, effect

   Products, producers
   Application
   Chemical name, structure
   Physical properties
   Product forms
   Oral toxicity, LD-50
   Major end uses

ENDRIN
   Persistence

   Persistent chlorinated
      hydrocarbons
   Recommended decrease usage
      over next 2 yean

   Poisoning cases

   Usage, U.S. Dept. of Agriculture
      survey

   Usage

   Chlorinated aryl hydrocarbons
   Use in agriculture

   Use on crops in the world

   Rice crops
   Use to control insects

   Sugarcane
   Use to control insects

   Cyclodiene organuchlorines

   Pesticide pollution of
      ground waters

   Water pollution from spraying,
      persistence

   Limits, potable water supply

   Spraying field, concentration
      in water

   Concentrations in water

   Concentrations in shellfish
   Concentrations in river basins
 68
 68
 68
 68
 68

640
Concentrations in cow's milk        140

Health hazards associated
   with agriculture use             155

Exposure of workers                156

Accidental exposure.
648
64ft
648
648
648
648
648


26
26
34

47
52

63
63
84

85
85

89
89

104


117


120

121

125


129
129
flour contamination

Persistent chlorinated
hydrocarbons
Recommended decrease usage
over next 2 years
Effect on phytoplankton
Concentiation by marine
organisms
Effect or. shrimp
Toxicity to mammals
Poisoning cases
Epidemics of poisoning
by pesticides
Acute oral toxicity
Acute dermal toxicity
Chlorinated h>^ocarbon
pesticides
U.S. pesticide production.
annual

Diene group
Effect on workers

Study of workers exposed
to pesticides

Effect on excitability
of nervous system

Reports of occupationally
related skin conditions

Analysts of tissues

Effect on monkeys
Poryn
-------
CHEMICAL SUBSTANCE INDEX
Induction of mutations

U.S. sales, use in agriculture

Effect on bailey

Products
Patent number
Chemical name, formula
Physical properties
Product form
Oral toxicity LD-50
Major end uses

ENT-50612
Mutations in barley

EPN
Behavioral changes reported
Human exposure

Acute oral toxicity to
adult rats
Acute oral toxicity to
weanling rats
Toxicity in young malr rats
Toxicity in aJult male rats

Conversion to anticholinesterase
agents in rat liven

Urine, indicator of exposure
Urine, indicator of exposure
p-nitrophenol in urine,
indicator

Potentiatfofi, administered
with malathion
Acute toxicity, in combination
with mala thion
Metabolite of EPN, inhibitory
effect on aliestrrase
In combination with malathion
Mechanism of action
Mechanism of EPN potenbation
of malathion

Synergism with malathion
Mechanism of action
Organophosphates
Tentogenic. chick embryo
EFTAM
Carbamates
Agricultural herbicide
606

610

640

648
648
648
648
648
648
648


584


413
413


427

427
427
427


428

447
448
448


512

512
513
513
513
513

523
523
665
665

70
70
Use rate
Persistence in soil
Toxicity to humans
Toxicity to warm-blooded animals

EPTC
Sc-rEPTAM

ER3ON
Phenoxy herbicides
Used for broadleaf werd control
Used for woody plant control
Systemic herbicide
Persistence in soil
Toxkity to humans
Toxicity to other animals
Use rates

8-ETHOXYCAFFEINE
Purine
Chromosome aberrations in
higher plants

Chromosome effects
Mutagcnic effect

ETHYL CARBAMATE
Rate of metabolism
Carcinogenesis
Catabolic rate in adult mice
Catabolic rate in newborn mice
Carcinogenic action
Tumorigenicity testing, rating
Tumorigenk

Effect on DNA, possible
Production of chromosome breaks

ETHYL ETHANESULFONATE
Mutations
ETHYL FENTHION
Toxicity in young male rats
Toxicity in adult mate rats
Toxicity to female rats, male
and female mice, male
guinea pigs
Toxicity to mate rats
ETHYL HEXANEDIOL(6-12)
Insect repellents
Human exposure
Recommended for mutagenic
testing
70
70
70
70





68
68
68
68
68
68
68
68


5S4

584

591
591


484
484
484
484
484
491
491

606
606


585
427
427


429
429

75
611

611
36

-------
                         CHEMICAL SUBSTANCE INDEX
ETHYL MERCURY
   Organic mercury compounds        66
   Use as fungicide                  66
   Use ntes                        66

   Ethyi mercury chloride,
      organism, dose, effect           640

   Products, producers               649
   Application                      649
   Chemical name, formula            649
   Physical properties                649
   Product form                    649
   Major end uses                   649

ETHYL MERCURIC
   PHOSPHATE
   Mercury compound               S83
   Chromosome aberrations in
      higher plants                  583

ETHYL METHANESULFONATE
   Induction of mutations            578

   Mutations in higher plants          584

   Mutations                       585

   Testing for mutagcnicity            595

ETHYL PARATHION
   See I'ARATHION

ETHYLENE CHLOROHYDRIN
   Fumigants                       612
   Formation of                    612
   Persistence in marketed
      materials                     612
   Induction of mutations
      inNeurospora                 612

ETHYLENE DIBROMIDK
   Halogen? ted hydrocarbon
      ncmatocides                  71
   Persistence                       71
   Toxkity to plants                 71
   Toxkity to humans               71
   Use ntes                        71

   Volatile fumigants                198
   Persistence in soil                 198
   Effect on soil organisms            198
   Residue in soil                   198
   Bromide absorption from sofl
      by certain plants               198
   Method of application to soil        198

   Effect on DNA                   606
   Fumigant
   Mutagcnic at"ion in Neurospora

ETHYLENEIMINE
   Mutations in higher plants

   Mutations

   Effect on DNA
   Etliyleneimincs

   Testing for abnormal fetviss

ETHYLENE OXIDE
   Mutations in higher plants
   Chromosome aberrations in
      higher plants

   Mutations

   Effect on DNA
   Epoxides

   Fumigants
   Breakdown
   Alkylating agent
   Muftgenic action

   Organism tested, dose, tffcct

   Products, producers
   Application
   Chemical name, formula
   Physical properties
   Product form
   Major end uses

ETHYLENE TH10UREA
   Ureas
   Oxidation product of nabam
   Tumorigenicity

FEKEMA ES-30-9
   Effect on human hair follicles
   Ingredients of

FENITROTHION
   Morbidity surveys of workers
   Occupational exposure
   Organophosphate compoun A
   Health effects of workers

FENTHION
   Organic phosphates,
      phenyl derivatives
   Use rates

   Queletox. formulation of Baytex,
      use in bird control
 612
 612


 583

 585

 606
 606

 669


 583

 583

 585

 606
 606

 612
 612
 612
 612

 640

 649
 649
 649
 649
 649
 649
492
492
492
405
405
345
345
345
345
 64
 64


 73


 37

-------
                         CHEMICAL SUBSTANCE INDEX
   Mosquito control                127

   Effect on crab larvae              209

   Morbidity effects of
      occupational exposure         345
   Morbidity surveys                345
   Occupational exposure            345
   Health effects of
      occupational exposure         345

FENURON
   Substituted urea herbicides        69
   Absorption through plant roots     69
   Persistence in soil                69
   Use rates                       69
   Toxicity to warm-blooded animals  69
   Toxicity to fish                  69

   Ureas                          608
   May affect DNA                 6CS

FERBAM
   Dithiocarbamate fungicide        66
   Used as soil drench               66
   Use rates                       66

   U.S. pesticide annual
      production                   315

   U.S. pesticide production, 1966     382

   Poisoning prevention and
      treatment                    452
   Use of deferoxamine in
      poisoning treatment            452
   Treatment of acute intoxication     452
   Fungicide                       452

   Tnmorigenicity testing, results      475
   Registered for use on food crops    475

   Organism tested, dose, effect       640

   Products, producers              649
   Application                     649
   US. patent number              649
   Chemical name, formula           649
   Physical properties               649
   Product form                    649
   Oral toxh-.ty. LD-50              649
   Major end uses                   649

   Testing for increase anomalies      673

FERMATE
   See FERBAM
FERRIC DIMETHYL
   DITHIOCARBAMATE
   See FERBAM

FLUOMETURON
   Substituted ureas herbicides         69
   Soil persistence                   69
   Absorption through plant roots      69
   Use rates                         69
   Toxicity to warm-blooded animals    69
   Toxicity to fish                   69

FLUORIDE
   Fluoride rodenticides              72
   Toxicity to warm-blooded animals    72
   Application restricted to
      licensed operators              72
   Properties                        72

   Insecticides for household use      151
   Sodium fluoride, use as
      insecticide                   151
   Sodium fluoride, mixed with
      pyrethrum for dusting          151

   Deaths from ingestion             158.

FLUOROACETAM1DE
   Fluoride rodenticides              72
   Toxicity to warm-blooded animals    72
   Restricted use                    72
   Properties                        72
   Organs affected                   72

FLUOROAKIL 100
   See FLUOROACETAMIDE

5-FLUORODEOXYURIDINE
   Chromosome aberrations in
      higher plants                  584

   Chromosome effects               591

FLUOROOROTIC ACID
   Effect on DNA                   607

S-FLUOROURACIL
   Effect on DNA                   607

FOLEX
   Acute toxicity to rats             427
   Toxicity to weanling rats           427
   Toxicity to adult rats             427
FOLPET
   Needed knowledge of sample
      composition, purity             11
38

-------
                          CHEMICAL SUBSTANCE INDEX
   Chlorine-containing fungicides       67
   Use                             67
   Use rate                         67
   Dermatitis in agricultural
      workers                      399

   Teratogenic activity, developing
      chick embryo                 438

   Tumorigcnicity testing, results      475
   Registered for use on food crops    475

   Tumorigenicity testing, rating      490

   Recommendation for
      teratogenicity testing           658
   Teratogcnicity                    658

   Teratogenic in chicken embryo     66*
   Teratogenicity  in mice            664

   Incidence of abnormal fetuses      666

   Testing for increase anomalies      673

FORMALDEHYDE
   Fumigants                      612
   Mutagenic action                 612

   Organism tested, dose, effect       640

   Products, producers              649
   Application                      649
   Chemical name, formula           649
   Physical properties                649
   Product form                    649
   Toxkity to plant j, animals         649
   Major end uses                   649

FORMALIN
   See FORMALDEHYDE

FREON112
   In combination with piperonyl
      butoxide                     545
   Hepatomas >n mice                545
   Acute toxicity in combination
      with piperonyl butoxide

FREONI13
   Acute toxicity in combination
      with 3,4 benzpyrene

FUdR
   See 5-FLUORODEOXY-
   URIDINE
546
546
        FUMARIN
           Anticoagulant rodenticides          72
           PK t~T»ies                        72
           Ac ac.->                          72
           Death, *- -m internal hemorrhage     72
           Frrcautioas i - use                 72

           Poisoning in hum-. <.<              158

        FUR/DAN
           Ca/bamates, mechanitm of action    65
           Use in agriculture                  65
           Use rates                        65

           Effects on DNA, possible          606

           Systemic insecticide               610
           Use                            610
        GAMMA BENZENE
           HEXACHLORIDE
           See LINDANE

        GARDONA
           Control of grasshoppers (Tucura)
              in Argentina                  92
           Poor or lack of grasshopper
              control                       92

        GEN1TE R-99
           Tumorigenicity testing, results      473
           Registered but not for use on
              food crops                    473

           Tumorigenicity testing, rating       490

        GENTIAN VIOLET
           Rosanfline dyes                  364
           Skin irritation, low
              concentrations        •        364
           Hemorrhages in skin,
              high concentrations            364
           Hemorrhages in mucous membranes 364
           Occupational exposure            364
           Accidental exposure              364
   Conjunctivitis
   Exposure to dust in air
   Symptom from exposure

GESATAMIN
   See ATRATRONE

GIBBERELUC ACID
   GibbereQins
   Responses in plants
   Use rate, application
                                          368
                                          368
                                          368
                                          74
                                          74
                                          74
                                                                             39

-------
                          CHEMICAL SUBSTANCE INDEX
   Tumorigencity testing, results      473
   Registered for use on food crops    473

 GIBBERELLIN A3
   See GIBBERELLIC ACID

 GLYCIDOL
   Epoxides                        58?
   Mutations In higher plants         283

   Mutation* in barley               S8S
   Mutations in Neurospon           585
   Mutations                       585

 GLYODIN
   Miscellaneous fungicides            67
   Use in agriculture                  67
   Uses                             67
   Use rate                          67

   Tumorigeiucity testing, rating      475
   Registered for use on food crops    475

 GRANOSAN
   See ETHYLMERCURY
   CHLORIDE

 GR1SEOFULV1N
   Hepatocarcinogenicity             485

   Interactions   .•                  546
   Interaction with
      piperonyl butoxide             546
   Mortality effects                  546
   Effects on weight in mice           546

   May affect DNA                  609

GUTHION
   Organic phosphate pesticides       64
   Use in home                     64
   Use in garden                     64
   Use rate                         64

   Residues in milk                  140
   Feeding of contaminated forage     140
   Metabolites                       140
  I
   Half-life values on fruits            142
   Residues, affected by rainfaO
      or wishing                    142
   Persistence on fruits               142

   Persistence of granular
      applications                   143

   Acute oral toxsrity. LD-SO          312
   Acute dermal toxkity. LD-50       312
   Occupational!/ related skin
      conditions                    366

   Psychiatric disorders               413

   M-tjbolism, by various animals     426

   Conversion in rats                 428

   Toxicity to rats,
      temperature effects             432

   Enzyme induction, effects on
      toxkity                       518

   May affect DNA                  608

   Us>; in agriculture, insecticide       610

   Te/atogenk in chick embryos       665
   Teratogenic in mice                665

GYPLURE
   Synthetic attractants               75
   U-c in control of fruit flies         75
HCN
   Set HYDROGEN CYANIDE

HEOD
   Concentrations in tissues of
      Tits, dogs                     265
   Relation of concentrations in
      tissues to dietar> intake         265

   Concentrations in tissues
      of rats, dogs                   266

   Administered to volunteers         267
   Concentrations in blood            267
   Correlation with other tissues       267

   Concentrations in tissues of rats     268
   Concentrations in blood of
      volunteers                     268

   Concentration in tissues vs
      exposure                      269
   Studies of, in cow's milk
      and eggs                      269

   Concentrations in tissue*           270

   Model, experimental results         272

   Studies in animals, implications     273
40

-------
                           CHEMICAL SUBSTANCE INDEX
   Tissue concentrations vs
      daily intake                    279

   Concentration in tissues vs
      time of ings' on               284

   Concentration h body fat
      vs liver                        285

   Concentration in adipose tissue
      dui jig post exposure            292

   Concentration in blood, liver
      during post exposure            293

   Concentration in human blood
      industrial exposure
      terminated                    294

   Residues, no sr.x differences
      in U.S.                        322

   Levels in Great Britain             328

   Readues in human tissues          386
   Reidue of aldrin and dieldrin       386

HEPTACHLOR
   Persistence                         9
   Contamination of environment       9

   Persistence       '                26
   Decrease usage over next  2 years     26

   Insecticides, use in U.S.            48
   Uses                             48

   Uses                             52
   Residues                         52
   MetaKilite heptachlor epoxide      52

   Residues fa milk                   S3
   Use for termite control             53

   Usage of insecticides,
      foreign countries                55

   Chlorinated aryl hydrocarbons       63
   Use in agriculture                  63

   Usage, world crops                 84

   Cereals, use to control pests         86

   Sugar beet, use to control pests      88

   Sugarcane, use to control  pests      89
Grasshopper control                91
Use banned, residues               91

Persistence                        104

Ground waters, contamination of    116

Ground water, analysis of           117

Potable water supply               122
Standards, limits                   122

Water concentrations               128

Examination of estuaries            129

Transport from soil to plants        132

Residues in soil, seeds              133
Plants, conversion of heptachlor
   to heptachlor epoxide            133

Dietary intake                     136

Dietary intake. FAO-WHO          137

Cows, grazing on treated fields,
   residues in meat                 139

Uptake by plants                   144

Persistence                        180
Decrease usage over next 2 years     180

Deaths of wild animals, birds        200

Effect on phytopbnkton            207
Effect on shrimp                   209

Effect on quail population          211

Actions to improve public Iicalth     239
No extension of present uses        239

Acute oral toxicity, LD-50          313
Acute dermal toxicity, LD-50        313

U.S. pesticide production,
   annual                         315

Effect on excitability of the
   nervous system                  360

Examination of autopsy tissues
   for                            386
Tumorigenicity testing, ratin-
   of heptachlor epoxide           470
Registered for use on food crops    470
                                                                                  41

-------
                          CHEMICAL SUBSTANCE I1IDEX
   Enzyme induction measurements
      in progress

   Rats, in combination with DDT,
      residues in adipose tissue

   May affect DNA

   Insecticides, use in
      agriculture

HEPTACHLOR EPOXIDE
   Needed knowledge of sample
      composition, purity

   Metabolite of hcplachlor
   Residues, concern of

   Found in dust from storm
   Transport in air

   Concentrations in lakes, plan's

   Potable water supply
   Standards, limits

   Water concentrations

   Examination of shellfish for
      estuary contamination

   Concentrations of, in alfalfa,
      in field containing
      heptachlor
   Residues in seed crops
   Conversion to in  plants.
      from heptachlcr
   Vapor pressure
   Half-life

   Acceptable daily  intake,
      FAO-WHO

   Foods of animal origin
   Source of, in diet

   Residues of, in fatty tissue
      of cattle

   Detection of, FDA Pesticide
      Analytical Manual

   Actions to improve protection
      of public health
   No extension of present uses

   Residues in human adipose tissue

   Human pesticide residues
520


527

609


610



 11
Residues, human adipose tissue     331

Efff ot on excitability of CNS       360

Detection in human tissues         387

Storage of, in males vs females      429

Concentration of, in human milk    449
Relationship to other chemicals     449

Judged positive for tumor
   induction                      470

Enzyme induction studies
52
52

113
113

119
122
122

128

129


133
133
1 1^
133
101
133
133

137
138
1 tO
138

139


239
239
269

320
in progress

Residues in human tissues

Residues in human tissues
Not commonly used in
household formulations
DELTA-HEPTACHLORO-
CYCLOHEXANE
Occupational exposure to lindane
Dermatitis from impurity in
lindane, humans
HERBAN
See NOREA
HERCULES 7531
See NOREA
HEXACHLOROBENZENE
Chlorine containing fungicides
Use in agriculture
Use rates
Epidemics of poisoning
Porphyria following ingestion of
Contaminated grain, human
ingestion
Effects of ingestion by humans
Effects of exposure, occupational
Contaminated grain.
human ingestion
Photoscnsitivity in rats
Induced porphyria
1,2,3,4,5.6-HEXACHLORO-
CYCLOHEXANE
Sec UNDANE
520

525

538

538


363

363





67
67
67
311
350

364
364
365

372
433
433



42

-------
                        CHEMICAL SUBSTANCE INDEX
HEXOBARBITAL
   Rat sleeping time,
      effect of DMSO

   Sleeping time, effect of
      organic phosphates

   Metabolism by liver
      microsomal enzymes
   Enzyme induction
417
518
520
520
   Sleeping time, effect of
      pipcronyl butoxide and sesamex  546

   Mouse liver mioosomes           554

HMPA
   Se; PHORATE

HYDRAZIKE
   Hydrazine derivatives             492
   Hydiazine, hepatomas iii mice      492
   Free hydrazine liberation          492

   Mutations in higher-plants         583

   Effect on DNA                  606

HYDROCYANIC ACID
   See HYDROGEN CYANIDE

HYDROGEN CYANIDE
   Inorganic compounds,
      u:e as pesticides               45
   Introduction in 1886              45
   Cont:ol of scale insects
      in California                  45
   Resistance of insects to chemical    45
   Use before World War II
      as insecticide                  45

   Funujants                      65
   Use in agriculture                65
   Use in public health               65
   Use rates                       65

   Effect on mammalian embryo cells   640
   Products, producers
   Application
   Chemical name, formula
   Physical properties
   Oral toxicity. LD-50
   Major end uses
649
649
649
649
649
649
NX2-HYDROXYETHYL)-
   HYDRAZINE
   Needed knowledge of sample
     composition, purity            11
   Tumorigenicuy testing, results
   Registered b-Jt not for use
      on food crops

   Hydiazine derivatives
   Tumorigeniciiy in mice

 BETA-HYDPOXYETHYL
   METHANE SULFONATE
   Mutations in higher plants

 HYDROXYLAMINE
   Chromosome effects
   Mutagenk effect

   DNA alterations

 HYDROXYUREA
   Chromosome aberrations in
      higher plaits
 HYVAR
   Mutagenic in plants

 BETA-INDOLEaUTYRIC
   ACID
   Auxins
   Auxins
   Use rates
   Uses

 IOXYNIL
   Nitrite herbicides
   Preemergence herbicide
   Toxicity to mammals
   SoD persistence
   Use rates

   Effect on DNA, possible

IPC
   See PROPHAM

IPECAC, SYRUP of
   Emetic
   Use in poisoning cases
IRON DITHIOCARBAMATE
   Tumorigenicity testing, raring

ISOCIL
   Base analogs
   May affect DNA

   Organism tested, dose, effect

ISODRIN
   Chlorinated cydodienes
 470

 470

 492
 492



 584
                                         591
                                         591

                                         604
                                         583

                                         576
                                         74
                                         74
                                         74
                                         74
                                         70
                                         70
                                         70
                                         70
                                         70

                                        607
                                        450
                                        450
491
609
609

640
                                        609

                                         43

-------
                         CHEMICAL SUBSTANCE INDEX
   May affect DNA                 609

I SOLAN
   Tumorigenicity testing, results      475
   Registered but not for use
     on food crops                475

   Tumorigenicity testing, rating      491

ISOPESTOX
   See MIPAFOX
2-ISOPROPOXYPHENYL
   N-METHYL CARBAMATE
   See BAYGON

ISOPROPYL
   m-CHLOROCARBANILATE
   See CHLORPROPHAM

ISOPROPYL METHANE
   Sl'LFONATE
   M itations in higher plants          584

   Mutations in barley               585

   Potential mutagenic compounds     595
   Mutagcnic testing                 595

ISOPROPYL
   N-PHENYLCARBAMATE
   See PROPHAM

ISOPROPYLPHENYL
   CARBAMATE
   Chromosome aberrations in
      higher plants                  583

1SOSAFROLE
   MDP synergists, prepared from
      isosafrole                     542

   Study of liver tumorigenicity        544

   Metabolites, use of thin-layer
      chromatography               547

   Metabolites                      548

2-ISOVALOYL-13-
   INOANEDIONE
   Sec VALONE

KAPATHANE
   Related to DDT                  63
   Use rates as insecticides            63
   Use rate as miticidcs               63
   Miscellaneous fungicides           67
   Use in agriculture                 67
   Uses                            67
   Use rate                         67

   Turaorigcnicity testing, results      475
   Registered but not for use on
      food crops                   475

KARMEX
   See DIURON

KELTHANE
   Compounds related to DDT         63
   Use rates as insecticides            63
   Use rates as miticidcs              63

   Accidents, by industry,
      by occupation                 154

   Acute oral toxicity, LD-50          313
   Acute dermal toxicity. LD-50       313

   OccupationaUy related
      skin conditions                366

   U.S. sales, use in agriculture         610
   fcisectjc'de                      610

   Organochlorine                   664
   Teratogenicity in mice             664

KEPONE
   Insecticides for household use       151
   Pellets us baits                    151
   Onset of action                   151
   Anticoagulants                   151
   Use in rodent control              151
   Toxicity                        151
   Resistance of some rodents         151

   Embryotoxicity in rats            664
   Embryo toxicity in dogs           664
   Organochlorines                 664

KEROSENE
   Pesticides before 1945             45
   Introduction in 18th century        45
   Toxicity to plants                 45
   Toxicity to insects                45
   Use as larvicidcs for mosquitoes      45

   Behavioral effects of solvents       417
   Signs and symptoms              417

KOCN
   Organism tested, dose, effect        640
44

-------
                          CHEMICAL SUBSTANCE INDEX
   Produc ts, producers                650
   Application                       650
   Oiemicil name, formula            650
   Physic?.! properties                 650
   Product form                      650
   Oral toxicity. LD-50               650
   Major end uses                    650

KURON
   I 'rine, indicator of exposure         448

LAMPRICIDE L-30-F
   Use in control of stream lampreys    73

LANNATE
   Carbamates                       65
   Action                           65
   Major use in agriculture             65
   Use rate:                         65

   Treatment of poisoning with
      TEAC, in mice                 454

LANS! AN
   Chlorine-containing fungicides       67
   Use in agriculture                  67
   Use rate-.                         67

LASSO
   Amides                          70
   Use as herbicides                   70
   Use as precmergent herbicide        70
   Persistence in soil                  70
   Use rates                         70
   Toxicity                         70

LAVOZIL
   Base analogs                      609
   Conversion into cpoxide            609
   May affect DNA                   609

LEAD
   Persistence                         9
   Environmental contamination        9

   Lead arsenate, introduction
      as insecticide against
      gypsy moth, 1892              45

   Persistent pesticides                105
   Toxic elements                    105
   Water solubility                   105

   Persistent pesticides                145

   Accidents, by industry.
      by occupation                 154
   Lead arsenate. U.S.
      pesticide production, 1966      315

   Occupational^ related skin
      conditions                     366

   Lead arsenate, U.S. pesticide
      production, 1966               382

   Urine, indicate, of exposure        448

   Treatment of pc isoning             451

   Lead dithiocartxunate              491
   Tumorigenicity, rating             491

LEAD ARSENATE
   Inorganic compounds              45
   Use as insecticide against
      gypsy moth                    45
   Introduction in 1892               45

   Inorganic insecticides              62
   Use on trees and shrubs to
      control chewing insects          62
   Use in baits for control of
      ants and cockroaches           62

   U.S. pesticide production           315

   U.S. pesticide production, 1966      382
   Case of damage to nervous system   413


                                   491
LEAD DiTHlOCARBAMATE
   Tumorigenicity testing, rating
LENOCIL
   Base analogs
   Conversion into rpoxidcs
   May affect DNA

LETHANF.
   Fumigants
   Use in agriculture
   Use in public health
   Use rate
   Ingredient in fly sprays

UME SULFUR
   Inorganic pesticides
   Use against scale insects

   Pest resistence, 1908
   Resistance by San Jose
      scale insect
                                   609
                                   609
                                   609
                                    65
                                    65
                                    65
                                    65
                                    65
                                    45
                                    45

                                    59

                                    59
                                                                                45

-------
                          CHEMICAL SUBSTANCE INDEX
   Inorganic fungicides                66
   Use in cgriculture                  66
   Use rates                         66

LINDANE
   Persistence                         9
   Contamination of environment       9

   Evaporation of, toxicity            23
   Discontinue use, human exposure    23

   Hematological disorders            34

   Use on world crops                 84

   Sugarcane                         89
   Use of lindane to control pests       89

   Chagas disease                     91
   Spraying of homes with gamma
      BHC                          91

   Evaporation "f, toxicity            102
   Discontinue use, human exposure    102

   Pesticides in rainwater,
      gamma BHC                    116

   Termite control, label
      including lindane                117

   Concentration in lakes,  plants       119

   Potable water supply                122
   Standards, limiting
      concentrations                  122

   Water concentrations               128
   Most frequently found pesticide      128

   Examination of shellfish for
      estuary contamination           129

   Intake in diet                     136

   Diet-r ' intake. FAO-WHO          137

   Residue retention in cow's mflk      140

   Exposure to, from home
    ,  vaporizers                     149
   Concentration in homes,
      manufacturing plants            149

   Accidents, by industry,
      by occupation                  1S4

   Effect on phytoplankton            207
 Effect on shrimp                  209

 H^.natological disorders            233

 Actions to improve protection
    of public health                 239
 No extension of present uses
    of lindane                      239

 Residues in human adipose tissue    269

 Anite oral toxicity, LD-50          313
 Acute dermal toxicity, LD-50        313

 Human pesticide residues            320

 Human adipose residues            331

 Blood dyscraaas                   350

 Effects, human population          352

 Dermatitis in workers, impurity
    in lindane                      363

 Occupationally related skin
    conditions                      366

 Ef'ect of thermal decomposition
    products of lindane on
   rcspintory tract                 369

 Hematological disorders            372

 Detected in body tissues            386

 Blood dyscrasias                    388

Prociuc lion of liver changes, rats     435

Enzyme induction studies, in
   progress                       520

Feeding to rats, effect on
   subsequent parathion
   poisoning                     524

Residues                          525

Stoiage of. effect of fat
   in diet                        526

DDT, effect on metabolism of
   lindane                       528

Storage of, by rats, on
   fat diets                       530
46

-------
                           CHEMICAL SUBSTANCE INDEX
   Etfrct oflow protein diets
      on acute toxic effects

   Daily intake of, actual vs
      calculated levels

   Mutagenic in plants

   Organisms tested, dose,
      biological effect

   Products, producers
   Chemical name, formula
   Physical properties
   Product forms
   Oraltoxicity
   Major end uses

L1NURON
   Substituted ureas
   Absorption through plant roots
   Persistence in soil
   Toxicity to warm-blooded animals
   ToxJchy to fish

   Mutitions in barley

   Organism tested, dose, effects

   May affect DNA

   Products, producers
   Application
   Chemical name, structure
   Physical properties
   Prod, ict form
   Oral toxicity, LD-50
   Major end uses

LOROX
   SeeUNURON

MALATHION
   Mosquito control

   Insect control, non-persistent

532

537
576

641
650
650
650
650
650
fen
650
69
69
69
69
69
584
642
608

650
650
650
650
650
650
650

Mosquito control

Daily intake
Acceptable daily intake.
WHO-FAO
Contribution to dietary intake
Effect of storage on residue?
Use, domestic
Effect on crab larvae
Acute oral U ijcity, LD-50
Acute dermal toxicity, LD-50
U.S. pesticide production, annual
Morbidity eifccts of
occupational exposure
Peripheral neuropathy
Effect on gastrointestinal tract
Sensitizcr in humans
Occupational^ related
skin conditions

Occupational exposure, effects
Intermediary product, diethyl
fumarate, sensitization

Penetration of

Sample skin matrix, effects of
127

136

137
138
141
147
209
312
312
315

345
360
361
364

366

399

399

403

405
54

59
   Aliphatic derivatives.
      organophosphorus compounds    64
   Uses                             64
   Use rate                          64

   Use in grasshopper control          91

   Non-persistent pesticide            104
   Uses                             104

   Atmospheric contamination         114
Behavioral changes,
   chemicals suspected             413

Oral toxicity to rats,
   comparative                   427

Effect of temperature on
   toxicity, rats                   432

Urine, indicator of exposure        448
Urinary exaction of               448

Administration with EPN,
   effect on toxicity               512
Potentiators of malathion
   toxicity                       S12
                                                                                 47

-------
                          CHEMICAL SUBSTANCE INDEX
   Hydrolysis of                    513

   Toxicity io rats                   514
   Toxicity to humans               514

   Interaction with EPN              523

   Effect of temperature on
      toxicity. MIS                  533

   Use in agriculture                 610
   Insecticide                       610

   Need for mutagcnic testing         611

MALEICHYDRAZIDE
   Growth retaidant                 74
   Uses                            74

   Tumorigenicity testing, results       475
   Registered for use on food crcps     475

   Non-tumorigenic in mice           492

   Mutations in higher plants          583
   Chromosome aberrations
      in higher plants                583

   Chromosome aberrations in plants   591

   Structure-activity-relationships      604

   Chromosome breakage             607

   Chromosome breakage in pLi ^ts     612

   Organism tested, dose, effect        642

   Products, producers               651
   U.S. patent number                651
   Chemical name, structure           651
   Physical properties                651
   Product form                     651
   Oral toxicity, LD-SO               651
   Major end uses                    651

MANEB
   Stability                         66
   Dithiocarbamate fungicides         66
   Use in agriculture                  66
   Use rates                         66

   Tumorigenicity testing, results       475
   Registered for use on food oops     475

MANGANESE
   Poisonings by heavy metal,
      derivatives of                  451
   dictation with EDTA              452

MANGANESE FTHYLENE
   (BISI DITHIOCARBAMATE
   Tumorigenicity testing, rating       491

MANZATE
   Sec MANEB

MARLATE
   Sec METHOXYCHLOR

M/TACIL
   Carbamate insecticide              72
   {.'-. in control of garden snails       72
   Use in control of slugs             72

   Toxicity                         454
   Production of death in mice        454
   Effect of tctraethylammonium
      chloride on                   454

MCPA
   °henoxy herbicides                68
   Uses                            68
   Systemic herbic'de                68
   Persistence in soil                  68
   Toxicity to humans                68
   Toxicity to animals                68
   Use rate                         68

   Disappearance in soil              203
   Effect of soil microorganism:       203

   Effect on earthworm population     204

MECLURE
   Synthetic attractants              75
   Use in control of fruit flies          75
   Use in control of melon flies        75
   Use in control of
      Mediterranean fruit fly          75

MEMMI
   Organic mercury compounds        66
   Use as fungicides for
      reed treatment                 66
   Use in L Jb and corm treatment      66
   Use in agriculture                  66
   Use rates          '.              66

2-MERCAPTOBENZO-
   THIAZOLE
   Tumorigenicity testing, results       473
   Registered for use on food crops     473

MERCURIC CHLORIDE
   Inorganic fungicide                66
48

-------
                         CHEMICAL SUBST. NCE INDEX
   Uses                            66
   Use rate                         66

MERCURY
   Salts of heavy metals, other
      than mercury, use review
      periodically                    10

   Persistence of in soil, salts of        45
   Volatilization in air                45

   Persistence                       105
   Toxicity                         105

   Persistence                       145

   Fungicides                       202

   Organic mercury, epidemics
      of poisoning                  311

   Organic mercury compounds
      occupationally related
      skin conditions                366

   Urine, indicator of exposure         44 8
   Saliva, appearance in              448
   Diagnostic use in poisoning         448

   Treatment of poisonings           451

   Mercury compounds              583
   Mutagenic effects in plants          583
   Chromosome effects in plants       583

   Pesticides containing mercury       612
   Production of, uses                612
   Deaths, tcrotological effects
      in Japan, seafoods              612

   Minamata disease                 661

   Mercury containing pesticides,
      results of studies               664

MESURAL
   Chemical structure of              557

META-SYSTOX-R
   Aliphatic derivative of
      organophosphorus compound    64
   Use in agriculture                  64
   Use rate                          64
METAISOSYSTOX
   Cases of human poisoning         414
   Signs and symptoms              414
METALDEHYDE
   Use in snail baits                   73
   Use- in slug baits                   73
   Action as attractant and toxicant     73
   Formulation with or without
      calcium arsenate                73

METEPA
   Mutations in barley                584

   Mutagenic threshold               598
   Use as chemoslcrilant pesticides     598
   Testing for mutagenicity            598

   Effect on DNA                   606
   Ethylcncimines                   606

METHAM
   Carbamates and thiocarbamates     607
   May affect DNA                  607

METHANE SULFONATE-
   BROMOETHYL
   Sulfonic acid derivative            584
   Mu.itions in higher plants          584

bcti-METHANE SULFONYL
   OXYBUTANE
   See MYLERAN

METHOMYL
   See LANNATE

METHOXYCHLOR
   Increase in usage                  51
   Uses, currently accepted            51
   Effectiveness against pests          51
   Effect of restricting usage of
      persistent pesticides            51
   Production and usage,
      comparison with DDT           51
   Use in fly control                 51

   Compounds related to  DDT         63
   Use rates                         63
   Potable water supply               121

   Standards, limits                  122

   Residues in cow's niilk             140

   Effect on phytopbnkton           207

   Studies in volunteers               296

   Experimental oral exposure,'
      humans                      301
   Safety levels 01 methoxychlor       301
                                                                              49

-------
                         CHEMICAL SUBSTANCE ISDEX
   Chlorinated hydrocarbon pesticide   313
   Acute oral toxicity, LD-50         313

   U.S. pesticide production, annual    315

   Toxicity to rats                  430
   Tendency to accumulation
      in fat and tissues              430
   Effect of carbon tetrachloride
      damage to liver, toxicity        430
   Eifcct of liver microsomct          430

   Estrogenic effects in rats           437

   Tumorigenicity testing, results      475
   Registered for use on food crops    475

   Enzyme induction, measurements
      in progress                    520

oeta-METHOXYETHYL
   METHANr SULFONATE
   Sulfonic acid derivative            584
   Mutations in higher plants          584

METHYL BROMIDE
   Use before World War II           45

   Fumigants                      65
   Use in agriculture                 65
   Use in public health               65
   Use rate                        65

   Accidents, by industry,
      by occupation                 154

   Fumigants                      198
   Residue remaining in soil           198
   Absorption by plints              198
   Control of pests in soil            198
   Volatility                       198

   U.S. pesticide production, annual    315

   U.S. pesticide production, 1966     382

   Use in agriculture                 611
   Fumigant                       611


3-ME fH YLCHOLANTHRENE
   Enzyme induction                518
   Effect on toxkity of Guthion      518

   Effect on drug metabolism
      in rats                       554
   Piperonyl butoxide effects.
      prior treatment with
      3-methj kholanthrene          554
 METH Vl-DEMETON
   Occupational exposure,
      morbidity effects              345
   Organophosphorous compounds    345

   Sysr.emic insecticides              610
   Use in apiculture                610

 3,4-METHYLENEDIOXY-
   C1NNAMIC ACID
   Excretion in rats                 547

 METHYLEUGENOL
   Synthetic attractants              75
   Use in contiol of fruit flies         75
   Use in control of melon flies       75
   Use in control of
      Mediterranean fruit flies        75

 N-METHYL.2-FORMYL
   PYR1DINIUM OXIME
   See 7.-PAM

 METHY1 LINOLATE
   Synthetic attractants              75
   Use in control of fruit flies         75
   Use in control of melon flies       75
   Use in control of
      Mediterranean fruit flies        75

 MtTH* T MERCURIC
   HYOROXIDF.
   Chromosome aberrations
      in higher plants               583

 METHYL METHANE
   SUIFONATE
   Mutations in higher plants          584

   Mutations                       585

   Potent mutagenic compound       595
   Testing for mutagenicity           595

 l-METHYL-3-NITRO.l-
   NTTROSO-GUANIDiNE
   Chromosome aberrations in
      higher plants                  584
   Nudeosides                      584

N-METHYL-N'-
   N1TROSOGUANADINE
   Mutations in higher plants          584

METHYL PARATtaON
   Use in U.S., use on cotton           47

   Organophosphates, phenyl
      derivatives                    64
   U«e rates                        64
SO

-------
                         CHEMICAL SUBSTANCE INDEX
   Non-persistent pesticide
   Uses

   Human exposure

   Poisonir.g, in comparison
      with parathion

   Pc/oonipg cases
                                  104
                                  104

                                  296
                                  307

                                  308
   Acute oral toxicity. LD-50         312
   Acute dermal toxicity, LD-50      312

   U.S. pesticide production, annual    3 IS

   U.S. pesticide production. 1966     382

   Urine, indicator of exposure        448

   May affect DNA                  608

   !ns:cticides, use in agriculture      610

METHYL ZIMATE
   &c ZIRAM

METlKAM
   Sti POLYRAM

MEV-NPHOS
   See PHOSDRIN

MGK264
   Use as pyrethrin syner&ist          65
   In combination with carbamates    65
                                  S42
                                  S42
                                  150
   Synergists for pyreihroids
   Use commercially

MH
   See MALEICIIYDRAZIDF

MILO
   Mothproofing chemical

M1LOGARD
   SeePROPAZINE
MPAFOX
   Organophosphate pesticide         360
   Demylination of nerve fibers       360
   Non-use in U.S.                  360

   Production of poryneuritis,
      humans                      413
   Non-use in US.                  413

   Organophosphorus poisoning       416
   Production of peripheral neuritis     416

   Fluorine containing organic
      phosphorus pesticide           419
   Damage to nervous system          419
   Non-use in U.S.                   419

M1REX
   Needed knowledge of sample
      composition, purity             1 1

   Use in fire-ant control              54

   Effect on r-hytoplankton           207

   Tumorigenicity testing, results       470
   Registered for use on food crops     470
   Tumorigenicity testing, rating

MITOMYCIN C
   Chumo^iTieabtfi
   Mutagenk effects

MOBAM
   May affect DNA

MOLINATE
   Carbamatct
   Use in agriculture
   Use rates
                                                                            489
                                                                            591
                                                                            591
                                                                            606
                                                                             69
                                                                             69
                                                                             69
   Toxicity to humans                70
   Toxicity to warm-blooded anirr Us    70
   Persistence in soil                  70

MONITOR
   Organophosphate                 60S
   May affect DNA                  60S

MONURON
   Substituted ureas                  69
   Absorption through roots           69
   Persistenc: in soil                  69
   Use rate, pteemergence             69
   Toxicity to warm-blooded animals    69
   Toxicity to fish                   69
   Use rate, soil steriiants              69

   Tumorigenicity testing, results      473
   Registered for use on food crops    473

   Tumorigenicity testing, rating      490

   Tumorigenicity testing, results      492

   Mutations in barley               584

   Organism tested, dose, effect       642
                                                                             SI

-------
                         CHEMICAL SUBSTANCL INDEX
   Products, producers              651
   Application                     651
   U.S. patent number              651
   Chemical name structure          651
   Physical properties               651
   Product form                    651
   Oral toxicity, LD-50              651

   Testing for increase anomalies      673

MORESTAN
   Fungicide                        67
   Use raw                         67
   Uses                             67

   Chlorinated carbamates            364
   Dermatitis in workers             364
   Occupational exposure            364

   May inhibit DNA synthesis         609

MOROCIDE
   Miscellaneous fungicides            67
   Uses                             67
   Use rate                         67

MORPHINE
   In treatment of poisoning          451

   Chromosome aberrations in
      higher plants                 533

MORPHOTHION
   Oximes, effect on toxicity         453

MOTOCIL
   Chemical structure               557

MYLERAN
   Mutations in higher plants         584
   Chromosome aberrations in
      higher plants                 584

MYRISTICIN
   Fatty livers, animals              543

   Metabolism in mice              543
NABAM
   Dithiocarbamate fungicides         66

   Use in agriculture                 67
   Use rates                        67

   VS. pesticide production, annual   315

   U.S. pesticide production. 1966     382
   Tumorigcnicity testing, results       475
   Registered for use on food crops     475

   Oxidation product of nabam,
      tumorigcnic in mice             492

   Testing for increase anomalies       674

NA1.ED
   Use in mosquito control            54
   Use by Department of Defense       54

   Organophosphorus compounds,
      aliphatic derivatives             64
   Use rates                         64
   Use in agriculture                  64

   Use in mosquito con trol            127

   Dermatitis in female
      chrysanthemum workers         364

NAPHTHALENE
   Use in 20th century                45

   Metabolism by house fly
      microsome enzymes             555
   Lffect of MDP compounds on       555

1-NAPHTHALENE
   ACETAMIDE
   Tumorigemcity testing, results       474
   Registered but not for use
      on food crops                  474

m-NArTHALENEACETIC
   ACID
   Auxins                          74
   Uses                            74
   Use rate                         74

ALPHA-NAPHTHOL
   Increase in abnoiniai fetuses         666

NAPTALAM
   Phthalamic aud herbicides          69
   Preemergent herbicide              69
   Use rate                         69
   Toxicity to humans                69
   Toxicity to warm-blooded animals    69

   AIanap-3, mutations in barley        584

   Organism, dose, effect              643

   Products, producers                651
   U.S. patents                      651
   Chemical name, structure           651
52

-------
                        CHEMICAL SUBSTANCE INDEX
   Physical properties               651
   Product form                    651
   Oral toxicity. LD-50              651
   Major end uses                  651

BETA-NAPTHOXYACETIC
   ACID
   Auxins                          74
   Uses                           74
   Use rate                         74

1-NAPHTHYL N-METHYL-
   CARBAMATE
   See CARBARYL

N-1-NAPHTHYLPHTHALAMIC
   ACID
   Sec NAPTALAM

2-N/ PTHYLTHIOUREA
   SecANTU

NEBIXARINE
   Mutations iii higher plants         583

NEMAGON
   Halogenated hydrocarbon
      nematoctdes                   71
   Persistence                       71
   Use rates                        71

NIA-10242
   Treatment of single oral
      LD-50 doses                  454
   Use of tetraethylaramonium
      chloride for treatment
      f»f poisoning                  454
   Carbamate                      454

NICOTrNAMIDE
   Testing for increase iriomalie*      674

NICOTINE
   Pesticides before 1945              44
   Discovery of, in 1809              44
   Use of tobacco to kill iphids        44

   Botanical insecticides,
      of lesser importance            63

   Use a* pesticide                   83

   Epidemics of poisoning*           311

   Chemical structure of             5S6

NTTRAUN
   Dinitroaniline herbicides           70
   Use in agricultuie                 70
   Use rates                       70
   Persistence                      70
   Toxicity to humans              70
   Toxicity to warm-blooded animals   70

   Use in agrculture                610
   Herbicide                       610

NITROGEN MUSTARD
   Mutations in higher plants         583
   Chromoso.ne aberrations in
      higher plants                 583

   Mutations                       585

   Chromosome aberrations          591
   Mutagenk effect                 591

p-NITROPHENOL
   Sec PARAN1TROPHENCL

NITROSOAMJNES
   Mutations in higher plants         583

N-NTTROSO-N-MEfHYL
   URETHANE
   Chromosome aberrations in
      higher plants                 584

NITROX
   See METHYL PARATHION

NORBORMIDE
   Rodenticide                     72
   Toxicity tc rats                  72
   Toxicity to other
      warm-blooded animals          72

   Specific toxicant for Norway rat    426
   Use as rat poison                 426

NOREA
   Substituted urea herbicide '       69
   Absorption through roots          69
   Persistence in soil                69
   Use rates                       69
   Toxicity to warm-blooded animals   69
   Toxicity to fish                  69

   Tumorigentcity testing, results      475
   Registered but not for use
      on food crops                 475

   May affect DNA                 608

OCTAMETHYLPYRO-
   PHOSPHORAMIDE
   See SCHRADAN
                                                                          53

-------
                         CHEMICAL SUBSTANCE 1NL EX
OCTYL, ROPYI. SULFOXIDE
   Insect repellent                   75

OMPA
   See SCHRADAN

OKDRAM
   See MOL1NATE

ORTHOCIDE
   Sec CAPTAK

O3THOPHENYLPHENOL
   May affect DNA                 606

OVEX
   Tumorigenicity testing, results      473
   Registered for use on food crops    473

   Tumorigenicity testing, rating      490

   Testing for increase anomalies      674

7-OXABICYCLO (2.2.1)
   HEPTANE-2,3-
   DICARBOXYL1CACID
   See ENDOTHALL

OXYDEMETOMETHYL
   See MET/VSYSTOX-R

2-1 AM
   Oiganophosphate poisoning,
      treatment with 2-PAM          348
   Carbamate poisoning, 2-PAM .-nay
      produce worse clinical signs     34 S

   Antidote, cholinesterase
      inhibitors                    453

PANOGEN
   Organic mercury compounds       66
   Use as fungicides for
      seed treatment                66
   Use in agriculture                 66
   Use ra.-es                        66

   May affect DNA                  t08

PARADICHLOROBENZENE
   Use in early 20th century          45

   Fumigants                      65
   Use in agriculture                 65
   Use for public health              65
   Use rate                        65

   Morbidity effects of
      occupational exposure          347
   Urine, indicator of exposure        448

   Organi- -.r. tested, dose, effects       642

   Products, produt •'s               651
   Applit Jtion                      651
   Chemical name, ••tructurr           651
   Physical proper res                651
   Product form                     651
   Oral toxicity. Li>50               651
   Major end use*                    651

PARANITROF.fENOL
   Metabolite of organophosphates     347
   Renal tubular damage from
      orcanophosphates              347

   Use of, as indicator of
      pari> thion absorption in man     403

   Metabolism of parathion. me
      of Miitrophenol cxoe'ion
      levels                        430
   Humaris, metabolism of parathion   430
   Influence of intcuurrcnt
      disease, skin and kidney
      pathology                    430

   Effect of ambient temperature
      or. excretion of p-nitrophenol,
      humans exposed to parathion    433
   Exposure of workers to
      parathion                    433
   Effect of temperature on
      excretion of p-nitrophenol      433

   Use of urine as indicator
      of poisoning                  448
   Use of urine as indicator
      in treatment of parathion
      poisoning                    448

PARAOXON
   Dermal absorption in rabbits       402

   Conversion of parathion by
      ultraviolet tight               433
   Toxicitv                        433

PARAQUAT
   Herbicides                       70
   Miscellaneous category             70
   Toxicity to mammals              70

   Postemergent herbicide             205
   Dessicant                        205
   Toxicity to fish and wildlife         205

   Effect of exposure of hands         365
54

-------
                        CHEMICAL SUBSTANCE INDEX
Effect on fingernails

Injury to lungs
Effect on eyes

Human exposure, effect
   on kidney, liver
Absorption from intestine
Lxcretion in urine
Symptoms of poisoning

Poisoning, effect on heart

Esophagcal casts, humans
Fatal cases, effects

L'ffect on fingernails

Personal indicators of
   over exposure
365         Disposal of containers.
              rinse water
159
Effect on DNA
Effect on plants
Use in agriculture
Herbicide
PARATHION
Absorption through skin
Humans, adverse effects on
Non-persistent pesticide
l)ses
Dermal, respiratory exposure,
humans
Atmospheric contamination
Ground waters
Potable water supply
Standards, limits
Water, contamination of
Daily intake, FAO-WHO
Leaching from soil by water
Accidents, by industry,
by occupation
Exposure of spray men
Spraying, exposure
Accidents, poisonings, deaths
607
607
610
610
81
81
104
104
112
114
116
121
122
124
137
144
154
155
156
157
368
368


370
370
370
370

371

373
373

405

446

607
607

610
610

81
81

104
104

112
114

116

121
122
124
137
144


154
155
156
157


Inhibition of cholinester-se
enzymes of ncuromuscular
system
Uses
Toxicity

Controlled human exposure

Acute poisonings, epidemiology

Poisoning, in comparison
with methyl paralhion
Dermal toxicity
Human ingestion, cliildicn

Epidemics of poisoning

Acute oral toxicity. LD-50
Acute dermal toxicity, LD-50

Epidemiology of poisoning cases
U.S. pesticide production, annual

Morbidity effects of
occupational exposure
Health hazards

Exposure of population
Peripheral neuropathy
Scnsitizer, humans
Occupational dermatitis

Occupational^ related
skin conditions
Hematological disorders
Dysuria, human exposure
VS. pesticide production. 1966
Paranitrophenol in urine.
major metabolite of
para th ion
Blood dyscrasias
Skin, decontamination of
Cutaneous metabolism
Dermal absorption in rabbits




206
263
263

296

306


307
307
308

311

312
312

314
315


347
347

352
360
364
364


366
372
373
382


388
388
400
401
402
55

-------
                   CHEMICAL SUBSTANCE INDEX
Respiratory exposure
Excretion in man

Penetration of

Sample skin matrix

Rats, treatment of.
effect on cholinestcrasc

Behavioral effects,
suspected chemicals

Behavioral changes

Species susceptibility

Death in children

Sex hormones, effect on
susceptibility to
parathion

Metabolism in mar.
Excretion of p-nitroplicnol
in urine

Temperature, effect on toxicity
Humans, temperature.
effect on toxicity
Ultraviolet tight, effect on
Conversion to paraoxon
Toxicity of paraoxon

Dermal vj inhalation
contamination

Urine, indicate; of exposure

TEA chloride, use as an
antago- ist

Prior feeding of rats with
aldrin, chlordanc or
lindane, effect on
poisoning
Effect of diet on

Temperature, effect on
toxicity, rats

May affect DNA

Insecticides, use in agriculture

Organism tested, dose, effects
402
402

403

405


411


413

417

427

428



429

430

430

432

433
433
433
433


445

448


454




524
532


533

608

610

643
Products, producers
Application
U.S. patent number
Chemical name, structure
Physical properties
Product form
Oral toxicity, LD-50
Major end uses

Tmtogcnic in chick embryo

P.SRISGREEN
Use of as pesticide in 1865
Inorganic compounds
Use against potato beetle

Restriction of use
Toxicity to humans
Persistence

Mosquito control
Application of pellets
Us* of dursban, comparison
with Paris Green
Economy of usage

PARZATE
See NABAM
PBA
Se? BENZAC

PCB
Error in analysis of DDT,
due to presence of PCB
Spread in environment since 1929
Analytical errors in analysis
of chlorinated hydrocarbons
Noted in British since 1966
Identified in fish.
wildlife and environment

Contained in human milk
Results of interpretation of data
Possible effects of storage
of samples in plastic
containers
Human pesticide residues
Interpretation of results of
human pesticide residues

PCNB
Needed knowledge of sample
composition purity

Chlorine-containing fungicides
Use in agriculture
652
652
652
652
652
652
652
652

665


45
45
45

62
62
62

127
127

127
127








257
257

257
257

257

258
258


258
319

319



11

67
67
56

-------
                           CHEMICAL SUBSTANCE INDEX
   Use rates

   Uiine, indicatoi of exposure

   Tumorigenicity testing, results
   Registered but not for use
      on food crops

   Tumoiigenicity testing, rating

   Recommendation  for tcratogenicity
      testing                        658
   Production of increased
      renal agenesis, mice
   Production of abnormal fetuses

   Testing for increase anomalies

PCP
   Miscellaneous insecticide
      compounds
   Use in preventing
      termite damage

   Chlorine-containing fungicides
   Use in agriculture
   Use rates

   Substituted phenol herbicides
   Use foi weed control
   Use as preemergence herbicides
   Persist :nce in soil
   Translocation in plants
   Toxicity to mammals

   Herbicides
   Residues in fooos
   Environmental contamination

   Epidemics of poisoning

   Chlorinated phenols
   Dermatitis in industry
   Excretion in urine

   Chlorinated phenols
   Neuritis from treating
      furniture
   Mixtures of
   Qdorinated phenols
   IrriUtio.n of respiratory tract

   Analysis of blood; diagnosis
      of intoxication

   Therapy
67

448

470

470

489


Atropine. use in poisoning
treatment
Poisoning symptoms, resembling
cltolinesterase inhibitors

Tumorigenicity testing, rating

May affect DNA

Use in agriculture
Fungicide

450

450

489

606

610
610
666
666

673
65
Organism tested, dose, effect        642

Products, producers                652
Application                        652
Chemical name, stricture           652
Physical properties                 652
Product for.n                      652
Oral toxicity, LD-50                652
Major end usej                     652

65
67
67
67

69
69
69
69
69
69

136
136
136

311
364
364
364
367

367
367


370
370

448
450
PEBULATE
See TILLAM
PENICILLAMINE
Antidote for htavy metal
poisoning
Chrlating agent for copper, lead
and possibly mercury

PENPHENE
Thiophene nematocides
Use for pest control on tobacco
Fumigant action
Use rates
Precautions before planting


PENTACHLOROPHENOL
See PCP
PENTA (PCP)
See PENTACHLOROPHENOL

PERTHANE
Acute oral toxicity, LD-50
Effects on respiratory system
Thermal decomposition products
Irritation to respiratory tract

Tumorigenicity testing, results
Registered for use on food crops
Tumorigenicity testing, rating
Testing for increase anomalies




452

452


71
71
71
71
71








313
369
369
369

473
473
489
674
                                                                                  57

-------
                         CHEMICAL SUBSTANCE INDEX
1'ETROLEUM
   Pesticides before 1945             45
   Use in insecticides in
      18th century                  45
   Toxicity to plants                 45
   Toxicity to insects                45
   Use as larvicides for mosquitoes     45

   Poisoning in children from
      petroleum products             157

   Human volunteers, DDT in
      petroleum, skin exposure        297

PHALTAN
   SeeFOLPET

PHENOBARBITAL
   Effect on DDT residues, humans     323

   Histologies! changes               434
   Enzyme induction                 434

   Effect on DDE blood levels,
      humans                       436

   Use in controlling convulsions       451

   Pretreatmcnt, effect on organic
      phosphate toxicity              518

   Effect on dicldrin                 528
   Enzyme induction                 528
   Effect OD dicldrin storage           528

   Enzyme induction                 529
   Effect on chlorinated hydrocarbon
      levels in humans               529
   Effect on DDE blood levels,
      humans                       529
   Antidote for acute DDT
      poisonings                    529

   Effect on piperonyl butoxide        555

PKENOTHIAZINE
   Use in treatment of phosdrin
      and parathion poisoning         41 /
   Potentiation of organophosphorous
      compounds                   417

   Tumorigenicity testing, results       475
   Registered for use on food crops     475


   Possible inhibition of DNA
      synthesis                      609
 PHENYI. MERCURIC
    ACETATE
    Organic mercury compounds        66
    Use as fungicides for seed
       treatment                     66
    Use in agriculture                  66
    Use rates                         66

    Metal-organic compounds           68
    Use in weed control                68
    Use in crabgrass control             68

    Tumorigenicity ttsting, results      475
    Registered but not for use on
       food crops                    475

    Mercurials                       664
    Fetal malformations in mice        664

 PHENYl MERCURIC
    HYDROXIDE
    Mutations in higher plants          583
    Chromosome aberrations in
       higher plants                  583

 PHENYTOIN
    See DiPHENYLHYDANTOIN

 PHOKATfi
    Organic phosphate compounds      60
    Plant systemic insecticides          60

    Organophosphorous compounds     64
    Use rates                        64

    Acute oral toxicity. LD-50         312
    Acute dermattoxlcily, LD-50       312

    Occupational^ related skin
      conditions                    366

    May affect DNA                  608

    Systemic insecticide               610
    Use in agriculture                 610

PHOSDRIN
   Organophosphorous compounds,
      aliphatic derivatives             64
   Use rate                          64

   Metabolism of pesticides
      by plants                      133
   Systemic insecticides               133
   Application, before harvest         133

   Toxicity to crab larvae             209
58

-------
                    CHEMICAL SUBSTANCE INDEX
Pesticides poisonings

Epidemics of poisoning
308
310
PHYTONADIONE
   See VITAMIN Kl

Acute orai toxicity, LD-50
Acute dermal toxicity, LD-50

Organophosphatcs
Health hazards
Toxicity
Routes of exposure
Direct cholinesterasc
inhibitors
Organophosphorous compounds
Topical effects

Occupationally related
skin conditions
Organophosphorous compounds
Contamination of eyes

Human poisoning by phosdrin
and/or p~:athion

Acute oral toxicity to rats
Toxicity to weanling rats
Toxicity 10 adult rats
PHOSPHAMIDON
Acute oral toxicity, LD-50
Acute dermal toxicity, LD-50

Mutat-'ons in barley
Organophosphate
May affect DNA
Systemic insecticide
Organism tested, dose, effects

Products, producers
Application
U.S. patent number
Chemical name, structure
Physical properties
Product form
Oral toxicity, LD-SO
Major end uses

PHOSPHON
Growth retardants
Uses

PHYGON
See DICHLONE

312
312

347
M7
347
347

364
364
3o4


366
367
367


417

427
427
427

3i2
312

584
608
608
610
642

6S3
653
653
653
653
653
653
653


74
74



PICLORAM
Herbicides, miscet'-inccu;,
category
Toxicity
Use in agriculture
Use in industry

Degradation in soils
Use in agriculture
Herbicide

PIPERONAL
MDP synergists, prepared
from pipcronal
Use of materials, limitations
Excretion by rat jits

Oxidation -
-------
                        CHEMICAL SUBSTANCE INDEX
   Malignant tumors of lymphatic
      system                      544
   Cocarcinogenic potential          544

-•-. In aerosol spray, animal
      experiment                  545
   Effect with freon administration    545

   Synergistic toxicity, Freons,
      other chemicals               546
   Effect on hexobarbital
      sleeping time, rats             546

   Excretion by dogs               547
   Excretion in rats                 547

   Metabolism, excretion in bile       548

   Metabolism of                  549

   Tentative metabolic fate
      in mam-nab                  552

   Inhibitor of Jrug
      metabolism, Mts              555
   Effect of phenobaibital or
      3-methylcholanthrene on       556

   Chemical structure               557

   Pyrethioid sy ncrgists             611
   Household applications           611

   Carbuyl phis pipetonyl
      butoxide, effects              666

   No significant increase in
      anomalies, as tested           674

PffERONYL SULFOXIDE
   Tumorigenicity testing, results      473
   Registered for use on food oops    473

   Tumorigenicity testing, rating      492

PfPERONYUCACID
   Metabolite in urine, dogs          547
'   Metabolites of chemicals          547

PTVAL
   Anticoagulant rodenticides         72
   Uses                           72
   Usente                        72

2-PTVALYL-l>
   INDANEDIONF
   SecPIVAL
 PLANAVIN
    See NITRALIN

 PLANOnX
    Tumorigenicity testing, results      475
    Registered for use on food crops    475

 PMA
    See PHENYLMERCURIC
    ACETATE

 POLYCHLORINATED
    BIPHENYLS
    SeePCB

 POLYRAM
    Dithiocerbamate fungicides        66
    Uses                           66
    Use rate                        66
    Stability                        66

 POTASSIUM. BIS
    (2-HYDROXYETHYL)
    DrrmOCARBAMATE
    Tumorigenicity testing, rating       491

 POTASSIUM CYANATE
    SeeKOCN

 PPJNCEP
    See SIMAZINE

 PROGESTERONE
    Enzyme activity, liver, rats         428
PROMETONE
   Heterocyclic nitrogen dcrr  dves     69
   Toxicity to mammals              69
   Uses                            69
   Use rate                         69
   Persistence                      69

PROPACHLOR
   Miscellaneous herbicide            70
   Toxicity                        70
   Uses                            70

   Oarbamates and thiocarbamates     607
   May affect DNA                 607

   Herbicide                      610
   Use in agriculture                610

PROPAN1L
   Amide derivatives                 70
   Herbicides                       70
   Persistence in soil                 70
   Toxicity                        70
60

-------
                         CHEMICAL SUBSTANCE INDEX
PROPAZINE
   Htterocyclic nitrogen derivatives
   Herbicide
   Toxicity to mammals
   Persistence in soil
   Uses
   Use rate

   Tumorigenicity testing, results
   Registered for use on food crops

   Testing for increase anomalies

PROPHAM
   Tumorigenicity testing, results
   Registered but not for use on
      food crops

   Tumorigenicity testing, rating

   Organism tested, dose, effects

   Products, producers
   Application
   Qiemical name, structure
   Physical properties
   Product form
   Oral toxicity, LD-SO
   Major end uses

   Recommended for further
      tetatogenicity testing

   Production of abnormal fetuses

   Testing for increase anomalies

beta-PROPIOLACTONE
   Chromosome aberrations in
      higher plants

n-PROPYL ISOMER
   Tumorigenicity testing, rating

PROPYLMETHANESULFONATE
   Mutations in higher plants

   Mutations

   Potent mutagenic compound

PRUSSICACID
   See HYDROGEN CYANIDE

PURINERIBOSIDE
   Chromosome aberrations in
      mammalian cells in tissue
      culture
                                          PYRAMIN
69
69
69
69
69
69
475
475

674


473

473
491
643

653
653
653
653
653
653
653

658
666
673
Miscellaneous herbicides
Toxicity
U**s

PYRAZON
See PYRAMIN
PYRETHRIN
Formulation varieties
Synerfist added

Tumorigenicity testing, results
Registered for use on food crops

PYRETHRIN I
Metabolism of
Chemical structure of
PYRETHRUM
Pesticides before 1945

Attempt to synthesize, 1920

Use against anopheles gambiae

Botanical insecticides

Mixed with sodium fluoride
Synergists to enhance action
Use of sy nergist with
Combined effects, with DDT
70
70
70




62
62

474
474


555
556

44

45

46

83

151
526
541

584


492


584

585

S95
S91
      and piperonyl butoxide,
      rats, liver                     544

QUELETOX
   A formulation of-Baytex
      insecticid-                    73
   Use in bird control                73

QUINOLINOLATE
   Metal organic fungicides           66
   Use for treatment of equipment     66
   Use to prevent rot and mildew      66
   Use rate                         66

RATICATE
   See NORBORMIDE

RED SQUILL
   History of use                   44

   World War II supply problems      45
                                                                             61

-------
                          CHEMICAL SUBSTANCE INDEX
   Botanical rodcnticide               72
   Toxicity to other
      warm-blooded animals           72
   Use rate                          72

   Toxicity to cats                   214

9-beta-D-RIBOFURANO-
   SYLPURINE
   See NEBULA RINE

RODANNITROB ENZENE
   Allergic dermatitis in
      agriculture workers             399

RONNEL
   Organic phosphate phcnyl
      derivative                     64
   Use rate                         64

   Air transport of, dust storm         113

   Phosp.ate ester pesticide           312
   Acute oral LO-SO toxkity value     312

ROTENONE
   Plant materials containing,
      used in 1848                   44

   Botanical insecticide               62

   Kills by inhibiting
      oxygen utilization by insect      63
   Toxicity to animals                63
   Swine, toxicity to                 63
   Uses                            63

   Plant extract as pesticide           83

   Water treatment processes,
      removal of                     122

   Use as piscicide for fish             213
   Effects on aquatic, insect life        213

   Toxicity to fish                   426
   Toxicity to certain mammals        426
   Toxicity to birds                  426

   SynergisU used to enhance
      toxicity of                    541

   Chemical structure of              556
ROTHANE
   SeeTDE
 RUELENE
    Organophosphate                  608
    May affect DNA                  608

 RYANIA
    Botanical insecticide               63

 SABADILLA
    History of use                     44
    Use as louse powders by
      South American natives          44

    Botanical insecticide               63

 SACCHARIN
    Chromosome aberrations in
      higher plants                  584

 SAFROLE
    Natural product                  542
    Used in preparation of
      pesticidal syncrgists            542
    Annual production per year         542

    Effect on bile acid or
      cholic acid concentration in
      male rats after injection         543
    Rat hcpatocarcinogen              543
    Hepatic damage and nodular
      degeneration, led with a
      riboflavin-deficient
      diet, rats                      543
    F brosis and deposits of
      ccroid pigment when fed
      to rats                        543

    Liver tumors in mice              544

    Metabolites in rat bile and
      urine after intravenous
      administration                 548
   Analysis for metabolites            548
   Metabolic pathway in mice         548

   Metabolic pathway in houscflies     549

SANEX
   Mothproofing product used
      in dry cleaning                 150
   Contains DDT                    ISO
   Exposure of employees
      and customers to DDT          ISO

SANITONE
   Mothproofing product used
      in dry cleaning                 150
62

-------
                         CHEMICAL SUBSTANCE INDEX
   Contains 100% DDT              150
   Exposure of cmplo) ees
      and customers to DDT          ISO

SARIN
   Toxkity to monkeys at
      different environmental
      temperature                  432
   Toxicity to hibernating and
      non-hibernating hamsters        432

   Toxkity to monkeys, effect
      of temperature                533

SAROLEX
   Organic phosphate nematicide      71
   DUzinon containing product        71
   Use rate                        71
   Uses                            71

SCHRADAN
   Controlled human exposure        296

   Contamination of eye             367
   Signs and symptoms of eye
      exposure                     367

   Acute oral toxicity                427
   Organophosphorous insecticides     427
   Toxicity to adult rats              427
   Toxicity to weanling rats           427

   Alteration of toxicity
      by enzyme induction           518
   Toxicity in nvce                  518

   Chemical structure of              556

SCOPOLAMINE
   Chromosome aberrations in
      higher plants                  583

SECONAL
   Behavioral effect of               418
   Effect on brain                   418
   Effect on continuous
      performance test              418

SELENIUM, DIETHYL-
   DITHIOCARBAMATE
   Tumongenicity testing, ra ting      491

SELENIUM DITH1O-
   CARBAMATE
   Tumorigenicity testing, rating      491

SEMAN
   Effect of DMSO on skin
      penetration                   403
 SEMESAN
   Organic mercury fungicide         66
   Use rate                         6C
   Uses                            66

,S£SAME OIL
   Source of methylenedioxyphenyl
      (MDP) derivatives              543
   Food use                        543
   Lipid vehicle for other agents
      in cancer research              543
   Co-carcinogenic activity in
      sarcoma production            543
   Sesamin obtained from            543
   Heated oil, effect on
      subcutaneous injection, mice     543
   Co-cr.rcinogcnic fractions of        543

 SESAMFX
   Synergist with carbamate
      insecticides                   65

   Synergist                        546
   Effect on hexobarbital
      deeping time, mice             546

 SESAMIN
   Isolstcd from sesame oil            543
   Methylenedioxyphenyl (MDP)
      derivative                     543
   Co-carcinogenic with
      3,4-benzpyrcne (bcnzo [a]
      pyrene)                       543

SESONE
   Phcnoxy herbicide                 68
   Use rate                         68
   Uses                             68

SEVIN
   See CARBARYL

SIDURON
   Sec TUPERSAN

SIGLURE
   Insect attractant, synthetic         75
   Use in control of fruit flies
      and melon flies                 75

SILVEX
   Phcnox> herbicide                 68
   Persistence in soil                  68
   Toxicity to man and other
      animals                       68
   Use rate                         68
   Uses                             68
                                                                             63

-------
                        CHEUICAL SUBSTAjtCE INDEX
Synthetic auxin for
agricultural use
Use rate
Uses
Water concentrations
Analysis of streams
74
74
74
128
128
   Urine indicator of exposure,
      human                     448

SIMAZINE
   Heterocycltc nitrogen derivative     69
   Uses                          69
   Use rate                        69
   Toxicity to mammals             69
   Persistence in soil                69

   Urine, indicator of exposure       448

   Tumorigenicity testing, results     47S
   Registered for use on food crops    475

   Tumorigenicity testing, rating      490

   Mutations in barley              584

   Organism tested, dose, effect       643

   Taken up by plant roots          645

   Products, producers              653
   Application                    653
   U.S. patent number              653
   Chemical name, structure         653
   Physical properties               653
   Product forms                  653
   Oral toxicity, LD-50             653
   Major end uses                 653

SINBAR
   SeeTERBACIL

SIX-TWELVE (6-12)
   See ETHYL HEXANEDIOL

SMDS
   SeeVAPAM

SODIUM ARSEN1TE
   Use as insecticide, weed killer      45

   Inorganic herbicides              67

   Use rates                       68

   Plant growth regulators           205

   Rodenticides, hazard to humans    214
   Poisoning, humans               362

 SODIUM BORATE
   Inorganic herbicides              67

   Use rates                      68

 SODIUM CHLOROPHENYL-
   PHENATE
   Chlorophenols                  373
   Occupational exposure.
      workers effects on             373

 SDDIUM.DIETHYL
   DITHIOCARBAMATE
   Tumorigenicity testing, rating      491

 SODIUM ETHYLENE(bij)
   DITHIOCARBAMATE
   Tumorigenicity testing, rating      491

 SODIUM FLUOALUMINATE
   Metallic salt<                    45
   Persistence in soil?               45
   Use as pesticide                  45

 SODIUM FLUORIDE
   Insecticides for household use      151
   Use with pyrethrum              151

 SODIUM FLUOROACETAft
   See COMPOUND 1080

 SODIUM FLUOROSILICATE
   Inorganic rodenticides             72
   In combination with zinc cyanide    72

 SODIUM ORTHOPHENYL-
   PHENATE
   Dusts containing, nasal and
      bronchial irritation             370

 SODIUM SULFATE
   Treatment of poisoning            450

   Treatment of poisoning            451
               i
 SPERGON
   See CHLORANIL

 STAM
   See PROPANIL

STREPTOMYCIN
   See AGRIMYCIN

STREPTONIGRIN
   Chromosome aberrations in
      higher plants                  583
64

-------
                         CHEMICAL SUBSTANCE INDEX
STROtANE
   Residues in meat, cow's milk

   Tumorigenicity testing, results
   Registered for use on food crops

   Tumorigenicity testing, rating

STRYCHNINE
   Botanical rodenticides
   Uses

   Rodenticides
   Hazards to humans,
      domestic animals

SUGARYL
   Chromosome aberrations in
      higher plants

o-SULFOBENZOICIMIDE
   See SACCHARIN

SULFUR
   Lime sulfur washes, 1886

   Lime sulfur sprays,
      resistance to

   Inorganic insecticides,
      sulfur derivatives

   Inorganic fungicides

   Accidents, by industry,
      by occupation

   Fungicides, production, volume

   Occupational^ related skin
      conditions

   Lime-sulfur mixtures, fungicides

   Dermatitis, conjunctivitis

   Pentavalent sulfur, plus
      chlorine atoms,
      non-tuntorigenic

   Sulfur mustard, chromosome
      effects in plants

   Unknown mechanism of action
SULFUR MUSTARD
   Chromosome aberrations in
      higher plants
SUMITHION
140

470
470

489


72
72
714
Alt
214

cot
583




45

59


62

66

154

202

366
368
«Q
JO7

490
583

604



583
Grasshopper control
Trial studier with; poor
control Li practice

SUTAN
Carbamates
Uses
Use rate

Persistence m soil
Toxicity to humans
Toxicity to v arm-Wooded animals
SYSTOX
Sec DEMETON
2.4,5-T
Needed knowledge of sample
composition, purity
Phenoxy heit.icido
Uses
Persistence in soil
Toxicity to humans
Toxicity to f nimals
Auxins
Uses
Use rates

Drift in storms

Potable water supply
Standards, limits
Water concentrations

Use, domestic, pounds
Disappearance in soil
Persistence
Study of soil microorganisms
after application
Chloracne
US. pesticidf production, 1966
Urine, indicator of exposure
Judged not positive
for tumoiigenichy
Registered but not for use
on food crops
Structure-activity relations
Hormone (auxin) analogs
91

91


69
69
69

70
70
70




11
68
68
68
68
68
74
74
74

113

122
122
128

147
203
204

204
365
382
448

475

475
604
604
                                                                             65

-------
                          CHEMICAL SUBSTANCE INDEX
   Us: in agriculture, herbicides       610
   Postemergcnce herbicides          610

   Organism tested, dose, effect       643
   Products, producers              653
   Application                     653
   Chemical name, structure          653
   Physical properties               653
   Product forms                   653
   Oral toxicity, LD-SO              653
   Major end uses                   653

   Teratogenic, restrict usage         658

   Tcratogcnic                     665

   Eflects in rats                   666
   Increase in abnormal fetuses       666

2,3,6-TBA
   See TRYSBEN

TCA
   Sec TRICHLOROACETIC
   ACID

TCTP
   Sec PENPHENE

TDE
   Diphcnyl aliphatic
      chlorinated hydrocarbon        63
   Used as insecticide and miticids      63
   Use rate                         63

   Acceptable daily intake,
      FAO-WHO                   137
   Expended dietary  intake
      (1965-1968)                 137

   Analytical  interference by
      Norwegian cod liver oil,
      gas chronvtography           257

   US. pesticide production, annual   315

TEDION
   Testing for increase anomalies      674

TULLURfUM. D1ETHYL
   DITHIOCARBAMATE
   Turr.origcnicity tc sting, rating      491

TELODRIN
   Effects on  industrial workers       409
   Occupational exposure            409
TF-LONE
   Halogenated hydrocjrbon
      nematocidcs                    71
   Persistence                        71
   Toxicity to humans                71
   Use as soil nematocides             71
   Toxicity to plants                  71
   Use rates                         71

TELVAR
   Sec MONURON

TEMIK
   Human intoxication               362

   May affect DNA                   607
   Carbamates and thiocarbamatcs     607

TtNORAN
   See CHLOROXURON

TEPA
   Mutagenic threshold, in mice        598

   Effect on DNA                   606

TEPP
   Aerial application of               110
   Conditions, effect on
      humans and wildlife            110
   Precautions for spraying            110

   Metabolism by plants              133
   Preharvest interval                 133

   Exposure of workers               156

   Acute oral toxicity, LD-SO          312
   Acute dermal toxicity, LD-50       312

   Occupational exposure, workers     347
   Organophosphates                 347
   Health hazards                    347
   Toxicity                         347
   Routes ci absorption              347
   Cholincsterase inhibition            347

   Organophosphorus compounds      364
   Direct cholinesterase inhibitors      364
   Effects of exposure                364
   Dermatitis                       364

   Organophosphorus compounds      367
   Effects on eye                    367

   Bronchoconstriction               369
66

-------
                         CHEMICAL SUBSTANCE INDEX
  Direct cholinestcrase inhibitors     406
  Effects on eyes                  406

TERBACIL
   Herbicides, miscellaneous
      category                      70
   Toxicity                        70
   Use in agriculture                 70
   Use in industry                   70

   May affect DNA                 609
   Conversion to epoxides            609

TERRACHLOR
   SeePCNB

TERRAZOLE
   CMorinc-containing
      fungicides                    67
   Use rate                         67
   Uses                            67

1,1,2,2-TETRACHLOSO-
   U-DIFI.UOROETHANE
   SceFRFONIia

TETRACHLORETHYLENE
   Effect on EEC                   451
   EEC similar to chlorinated
      hydrocarbon insecticides        451

TETRACHLOROMETHYLENE
   DIOXYBENZENE
   Metabolism in microsomal
      preparations                 548

TETRACHLOROTHIOPHENE
   See PENPHENE

TETRADIFON
   Tumorigenicity testing, results      475
   Registered for use on food crops    475

   Tumorigenicity testing, rating      490

TETRAETHYLAMMONIUM
   CHLORIDE
   Use in treatment of carbamate
      poisoning, mice               454

TETRAETHYLPYRO-
   PHOSPHATE
   SeeTEPP

U.J.9-TETRAMETHYL-
   URIC ACID
   Purinc                         584
   Chromosome aberrations in
      higher plants                 584
THALIDOMIDE
   Need for s; stem to recognize
      teratogrnic agents             601

   Disaster, need for
      teratogt-nicity testing          658

   Tcratogenfcity of                659
   Pregnant women.
      effects   children             659

   Malformat.:  s produced by        661

THALLIUM SI LFATE
   Salts of, use as pesticides          45

   Inorganic rodenticides             72
   Use rates                       72

   Use in starting control             73
   Restricted uses                   73
   Poisonous properties              73
   Cumulation                     73

   Use as insecticide                 363
   Use as rodcnticide                363
   Poisoning it children in U.S.        363

   Hair loss, chronic poisoning        365

THANITE
   Fumigant                       65
   Use in agriculture                 65
   Use in public health              65
   Use rate                        65
   Use in fly sprays                 65

THIMET
   Sec PHORATE
2,2-THIOBIS
   (4,6-DICHLOROPHENOL)
   Tumorigenicity testing, rating      489

thio-TEPA
   Effect on DNA                  606
   Ethytenetmincs                  606

THIODAN
   Acute oral toxicity, LD-50         313
   Acute dermal toxicity, LD-50      313
   Chlorinated hydrocarbon
      pesticides                    313

TH1OMETON
   Morbidity effects,
      occupational exposure         347


                                  67

-------
                        CHEMICAL SUBSTANCE INDEX
THIRAM
   Dithiocarbamate fungicides
          Psradichlorobenzene.
66          use to control mold
Uses
Use rates
Use in bird control
Tumorigenicity testing, results
67
67
73
475
TOCP
See TRIORTHOCRESYL
PHOSPHATE
TORPON
See PICLORAM
   Registered for use on food crops     475
   May affect DNA
607
                                        651
       TOXAPHENE
          Use of, with decreased DDT usage    9
Teratogeiu'city in hamsters
Non-teratogenicity, results

Testing for increase anomalies
TILLAM-6-E
Carbamates
Use as herbicide
Use rates
Preemergence herbicide
Persistence in soil
Toxicity to humans
Toxicity to warm-blooded animals
Tumorigcnicity testing, results
Registered for use on food crops

Tumorigcnicity testing, rating
TOBACCO
Pesticides before 1945
Use in France to kill
aphids, 1763

Agricultural crops,
pest control economics
Penphene, use to control
nematode pests
Insecticide usage, crops

Pests, use of DDT. BHC,
( cyclodfenrs to control
Losses due to insects

Development of resistant plants

Light traps, insect control
Acrytonitrile, use as
f umigant for stored crops
Ferbam, use to control
fungus diseases
665
665

673

69
69
69
69
69
69
69
475
475

491

44

44


58

71
84


89
89

162

166 •

645

649
Toxicity to fish

Recommended decrease usage
next 2 years
Us?.ge, Dept. of Agriculture
survey

CHorinated aryl hydrocarbons
Ur« in agriculture

Vie in controlling
undesirable fish
UK on crops in the world
1
Rice crops
Use to control cutworms
Oilseeds
Us*1 in foreign countries.
insect control

Cyclodiene organochlorines

Spraying field, drift, residue
Atmospheric contamination by
pesticides
In lakes, effect on
Gsh population

Limits, potable water supply
Wster treatment processes
tor removing toxaphene

Removal of toxaphene at
municipal water plant
Fed to cattle, residues in fat
Concentration in cow's mik
Spraying of cattle, residues
in tissues, milk
18


26

47

63
63


73
84

85
85
90

90

104

109

114

119

122

122


123
139
140

140

-------
                         CHEMICAL SUBSTANCE INDEX
   Recommended decrease usage
      next 2 years                  180

   Effect on phytophnkton           207

   Effect on crab larvae              209

   Effect on mortality
      of fish-eating birds             211

   Use as piscicide to control
      carp, catfish                  213
   Persistence                       213

   Epidemics of poisoning
      by pesticides                  311

   Acute oral toxicity                313
   Acute dermal toxicity             313
   Chlorinated hydrocarbon
      pesticides                    313

   U S. pesticide production, annual    31S

   Effect on excitability
      of nervous system              360

   Reports of occupationally
      related skin conditions          366

   VS. pesticide production           382

   liver changes in rats              43S

   Effect on microsoma! enzymes      519

   VS. sales, use in agriculture         610

TOXOGONIN
   Use in Europe                    453
   Antagonism of cholinesterase
      inhibitors                    453
   Mechanism of action              453

TREFLAN
   See TRIFLURALIN

TRIBUTYRIN
   Inhibition of enzymes by
      organophosphates              513

TRICHLORACETIC ACID
   Aliphatic acid herbicides           69
   Uses                            69
   Toxicity to humans               69
   Toxicity to warm-blooded animals   69
   Health hazard, discussion           69
TRICHLORFON
   Organophosphorus compounds,
      aliphatic derivatives            64
   Use rate                        64
   Use in agriculture                 64

   Toxicity to rats                  427
   Effect of age                     427

l,l.l-TRIC»LORO-2,2-
   bis(p
-------
                         CHEMICAL SUBSTANCE INDEX
   Use in control of melon flier        75
   Use in control of
      Mediterranean fruit fly          75

U.7-TRIMETHYL
   XANTHINE
   See CAFFEINE

TRIORTHOCRESYL
   PHOSPHATE
   Neuronal lesions, polyneuritis      413

   Delayed neurutoxitiiy            424
   Production in chickens, calves      424

TRIPHENYLTIN ACETATE
   Tumorigenicity testing            474
   Not registered as pesticide          474

TRIPHENYLTIN HYDROXIDE
   Registered for use on food crops    474
   Registered for use on
      non-food items                474
   Pesticide                        474
   Not tested for carcinogenicity      474

TR1PRUF
   Mothproofing chemical            150

TRTTHION
   Acute oral toxicity, LD-50         312
   Acute dermal toxicity, LD-50      312

   Occupational]/ related
      skin conditions                366

   Occupational exposure,
      suspected chemicals  '         413

   Effect on rats, weanling vs adult     427

   Organophosphates                665
   Cholinesterase inhibitors           665
   Teratogenic to chick embryos      665

TROPITAL
   Preparation of                   542

   Effect on bDe acids and
      cholesterol levels, rats          543

   Effect on hexobarbital
      metabolism, sleeping time, rats   546
   Metabolism of
   Metabolism of
548
549
   Tentative metabolic fate of
      in mammals                   553

TRYi'AN BLUE
   Testing for increase in
      abnormalities                  669

   Increase in anomalies, mice         670

TRYSBEN
   Benzoic acid herbicides             68
   Persistence in soil                  68
   Toxicity to mammals              68
   Use in agriculture                  68
   Use rates                         68

   May affect DNA                  606

TUPERSAN
   Substituted ureas                  69
   Absorption through root system     69
   Persistence in soil                  69
   Toxicity to warm-blooded animals   69
   Toxicity to fish                   69
   Use rates                         69

TURPENTINE
   Pesticides before 1945              45
   Use in 18th century                45

UC 10854
   Giemical structure of              557

URETHAN
   See ETHYL CARBAMATE

VALONE
   Anticoagulant rodenticides          72
   Use, precautions                  72
   Properties                       72

VANCIDE BL
   Tumorigenicity testing, results       473
   Registered but not for use
      on food crops   <               473

VANCIDE PB
   Tumorigenicity testing, rating       489

VAPAM
   Dithiocarbamate fungicides         66
   Use in agriculture                  66
   Use rates                         66

   Stability                         67
   Control of target organism          67

   Effect on DNA, possible            607
70

-------
                         CHEMICAL SUBSTANCE INDEX
VAPONA
   See DICHLORVOS

VEGEDEX
   Carbamales
   Use as herbicides

   Use rate
   Persistence in soil
   Toxicity to humans
   Toxicity to warm-blooded animals

VERNAM
   Caibamaies
   Use as herbicides
   Use in agriculture

   Use rate
   Persistence in soil
   Toxicity to humans
   Toxicity to warm-blooded animals

VERNOLATE
   See VERNAM

VITAMIN Kl
   Antidote for indancdione
      derivatives

VORLEX
   Cyanate ncmatocides
   Soil furrigant
   Formulation
   Use rate
   Precautions for planting

WARFARIN
   Anticoagulant rodenticides
   Properties
   Uses

   Poisoning cases, human

   Epidemics of poisoning

   Temperature, effect on toxicity

XYLENE
   Behavioral effects of solvent
   Effects of intoxication

YELLOW PHOSPHORUS
   Miscellaneous pesticides
   Ingestion, poisoning signs
      and symptoms

ZEATIN
   Cytokinins



69
69

70
70
70
70

69
69
69
70
70
70
70



451

71
71
71
71
71

72
72
72

158

311

432

417
417

371

371


74
Uses
Use rate
ZECTRAN
Carbamate insecticides
Uses
Use rate
Toxicity to bud worm, in
comparison with DDT
Effect of sunlight on
Urine, indicator of exposure

TEAC, atropine, treatment
of poisoning
Tumorigenicity esting, results

Registered but i>ot for use on
food crops
Tumorigenicity testing, rating
Testing for increase anomalies
ZERLATE
Sec ZIRAM
ZINC
Metallic salts, use as
pesticides

Inorganic rodenticides,
zinc phosphide
Fungicides, heavy metals
Heavy metal derivatives.
treatment of poisoning

ZINC, DIETHYL
DITHIOCARBAMATE
Tumorigenicity testing, rating

ZINC DITHIOCAPBAMATE
Tumorigenicity testing, rating
ZINC ETHYLENE ibis)
DITHIOCARBAMATE
Tumorigenicity testing, rating
ZINC PHOSPHIDE
Inorganic rodenticides
Uses

Rodenticides
Hazard to humans, domestic
animals
74
74

65
65
65

111
111
448


454
473


473
491
673




45


71
202

451



491


491


491

72
72

214

214
                                                                             71

-------
                          CHEMICAL SUBSTANCE INDEX
ZINEB
   Dithtocaibamate fungicides         66
   Uses                             66
   Use rates                         66
   Stability                          66
   U.S. pesticide production, annual    315

   U.S. pesticide production, 1966      382

   Tumorigenicity testing, results       474
   Registered for use on food crops     474

ZIRAM
   Dithiocarbate fungicides            66
   Use in agriculture                  66
   Use rates                         66
   Stability                          66
   Control of target organisms         66

   Dithiocarbamates                 364
   Dermatitis                       364

   Occupational exposure, effects      369
   Respiratory irritation, humans      369
   Dithiocarbamates                 369

   Tumorigenicity testing, results      475
   Registered for use on food crops    475

   May affect DNA                  606

ZOXAZOLAMINE
   Effect of piperonyl butoxide
      on paralysis time, mice         546
72

-------
                                SUBJECT  INDEX
Subject                             Page

ABORTION
   Abortion, spontaneous             570
   Chromosome aberrations           570

   Mutation induction by seed
      treatment                     576
   Measurement of responses to
      mutagen treatment, pollen
      abortion                      576

   Pollen abortion in mature
      flowers                        578

   Abortions, captan, animals         664

   Chlorinated hydrocarbons          674

   Abortion, spontaneous, humans     675

   Discussion of conclusion of
      results                        675

ABSORPTION
   Study of, in man                   33

   Metal salts, absorption from
      •oil by plants                   45

   Stomach poison*, absorption
      from digestive system            61

   Chemical repeUuits, loss by
      absorption through skin          75

   Modes of entry of pesticides
      into body, skin absorption       112

   Analysis of 2.4-D in water
      samples activated by
      carbon absorption              126

   Persistent pesticides, toxic
      by skin absorption             135

   Paratrdon exposure, humans,
      absorption from skin            155
Subject                           Page


  Pesticide exposure, humans,
     absorption cf                  156

  Accidental poisoning, skin
     absorption of pesticides         158

  Of X-rays and gamma rays          167

  Extraction of pesticides
     from water using carbon
     absorption method             174

  Analysis of 2,4,5-T in soil
     by ultraviolet absorption        203

  Of yolk sac of Hsh, DDT
     effect on mortality             209

  Of pesticides in humans,
     studies                        232

  Research needs,  absorption of
     pesticides in humans            240

  Surveillance of occupationaUy
     exposed persons, blood
     studies to determine
     hazardous absorption           242

  Route of entry of pesticides         263
  Percutaneous absorption,
     occupational exposure           263

  Route of entry of
     organochlorine insecticides       264

  Controlled human exposure         295

  DDT, effects; differences not
     associated with absorption       298

  Experimental oral exposure
     to dkldrin, relationship
     between absorption and
     accumulation                  3C1
                                                                                 73

-------
                                   SUBJECT INDEX
   Calculations of levels of
       intake, absorption, storage
       of dicldrin
   Modes of interactions
   Organochlorines, effect of fat
      diets on absorption

   Benzene hexachloride toxicity,
      rats, effect of high fat diet
ABNORMAL
   Pesticides, effects on fish.
      seeking of abnormally warm
      waten
                                  302
   Health hazards of parathion,
       phosdrin, TEPP, ease of
       absorption                     347

   Systemic effects,
       organophospliatcs, dependent
       upon rate of absorption         360

   Organophosphorus compounds,
       gastrointestinal absorption'of    361

   Systemic poisoning, routes of
       absorption, skin,
       respiratory tract                383

   Study, Parathion, Paraoxon
       penetration                    402

   Acute, chronic poisoning           407

   Organophosphorus agent,
       rapid skin absorption            411

   Effect of fat diet on DDT
       toxicity, animals, effect on
       absorption  of DDT              < 31

   Temperature effects on toxicity
       of parathion. mice, rate of
       absorption                      432

   EDTA, use in chelation of
       metals, oral administration,
       absorption  of metal             452
                                 Sll
   Interactions of pesticide
      residues with detergents,
      absorption of materials
      from alimentary tract           526
                                 530
                                 533

Human exposure to pesticides       611

Human exposures to pesticides      657
Pesticide 'cvcls and disease,
   comparison of normal and
   abnormal tissues, DDT, DDE     328

Organophosphatcs, occupational
   exposure, EEC abnormalities     348

Diene groups, EEC abnormalities     34?

Occupational exposure, abnormal
   chemistry, from Community
   Studies Surveillance Programs     357

Occupational exposure, abnormal
   distribution of serum and
   urine amino acids               388

Occupational exposure, neurologic
   abnormalities                   389

Occupational exposure to DDT,
   abnormalities of physical
   examinations and laboratory
   tests                           391

Paraquat, diquat, production
   of abnormal fingernail*           405

Occupational exposure,
   abnormalities in behavior        407

DDT poisoning, animals,
   abnormal susceptibility
   to fear                         425
                                             Mutagenicity, results of
                                             Mutz'ions, abnormalities
                                 567
Mutations, physical
   abnormalities                  570
Mutations, chromosome
   aberrations, abnormalities       570
                                 571
                                 210
Mammalian methods, of testing
   for mutagenicity,
   abnormalities                  587

Correlation between mutation
   production and chromosome
   abnormalities                  588

Children, abnormal at birth
   recording of anomalies          600

Monitoring of gross
   abnormalities             .     601

Carbnyl;ebnonnal mitosis         639
74

-------
                                   SUBJECT INDEX
   2,4-D; abnormal mitosis
   DCNA; abnormal meiosis
   Dicamba; abnormal meiosis

   Isocil; abnormal meiosis

   Monuroa; abnormal meiosis

   Naptalam; abnormal meiosis
   Paradichlorobenzene:
      abnormal mitosis

   Congenital malformations,
      definition

   Exposure to teratogen; induction
      of congenital abnormalities

   Birth certificates, recording
      of abnormalities

   Production of abnormal fetuses;
      2,4,5-T.mice
   2.4D; production of abnormal
      litters

   Production of abnormal litters,
      Dr ISO solvent

   Production of abnormal
      fetuses, mice

   Production of abnormal fetuses

   Production of abnormal fetuses

   Production of abnormal fetuses

ACARIC1DES
   Sulfur, polysulphides, and
      related compounds
   Conjunctivitis in humans

ACCIDENTS
   Regulations needed to control
      disposal of pesticides.
      containers, sources of
      accidental poisonings

   Accidents from use

   Needed safe methods of disposal
      of pesticides, containers, to
      prevent accidents

   Evidence of human exposure,
      ax reports, accidental
   Case reports, accidental
      poisoning by organochlorines,
      effect*
640
640
640
641
642

643
643

657


659

662

666

666

66?

668
670
671

672


368
368


18
22

24

33


33
Manufacturer, need for label
information on procedures
in accidents
In use of pesticides
Needed methods of disposal of
pesticides, containers, to
prevent accidents
TEPP, poisoning, conditions
Potential danger to operators

Private wells contaminated
by accidental spills
2,4-D; accidental contami-
nation of well water
Potential effects of spillage
on water, transportation
Household uses, increased
danger of accidental
poisoning
Preventative mc.'juies, workers
Agricultural use of chemicals.
accidents in
Accidents, by chemical, by
industry, by occupation
In U.S., poisoning
Accidental ingestion, by
children
Accidental ingestion, by
children

Accidental incorporation of
insecticides in animal feed
Prevention of
Accidental spills
Package design, to minimize
accidents
Fumigation, effects on
non-target organisms

Seed treatment, accidental
ingestion of seeds by farm
animals, poultry


77
101


103
110
113


117

117

122


145
153

153

154
157

157

158


159
160
192

193

I9S



200
                                                                                  75

-------
                                     SUBJECT INDEX
    Dinoseb. accidental
       contamination of lakes,
       streams, effect on
       aquatic organisms               203

    Case reports, accidental
       poisonings                      231

    Developing countries, accidents
       from improper storage of
       pesticides                       234

    Pesticide protection teams, to
       set-up reporting system,
       accidents, misuse of
       pesticides                       241

    Effects on humans, accidental
       Digestions                       251

    Studies of groups exposed,
       occupational^, accidental        256

    Home poisonings, children           263

    DDT, accidental ingestjon of         296

    DDT, accidental Digestion of         297

    Mortality rates, accidental
       poisonings                      305

    Accidental Digestion of
       pesticides, children              306

    Accidental Digestion, children        308

    Epidentics of poisonings,
       accidents, pesticides              310

    Pesticide poisonings, accidents        314

    DDT. dieldrin, comparison with
       persons accidentally killed        322

    DDT residues, hunrns, killed
       accidentally                    329

    Accidental poisoning of adults        356

    Gentian violet, accidental
       exposure, effects                364

    Occupational accidents.
       pesticides                      366

    Bsdrin accidental occupational
       exposure of human, eye         367
   Dinitrophenolic pesticides,
      accidental exposure to           368

   CUordane. accidental
      Digestion of                    372

   Accidental exposure, humans       383

   Aviation accidents, pilots           406

  . Study of DDT, DDE storage in
      various population*             430

   Protection of eyes from
      accidental contact of
      pesticides                       443

   Accident rate for aerial sprayers
      vs commercial pilots             446

   Accidental discovery that
      chtordane causes enzyme
      induction, animals              517

   Dairy herd, accidentally
      exposed to aldrin-contaminatcd
      feed                           529

   Population monitoring.
      accidental ingestion             661

ACCUMULATION
   Of pesticides in the environment     22

   Needed studies on rates of
      accumulation of pesticides
      in the environment              23

   Carbarn? te insecticides, not
      accumulated in fats             64

   Phenylacetk add, not expected
      to accumulate in soil from
      year to year                     68

   Of pesticides in the environ-
      ment              '            101

   Spray appb-jtkm for spruce
      budworm, not accumulate in
      pbnt and animal systems         111

   Shellfish, accumulators,
      proposed as monitors of water
      quality for pesticides             118

   Pesticides in water, increased
      biological accumulation in
      food chain                      120
76

-------
                                    SUBJECT It JEX
   Fate, influence on irrigated
      agriculture                     124

   Arsenic, accumulation in soil        145

   Of persistent pesticides in
      adipose tissue, occupational
      exposure vs general population   153

   Studies on accumulation of
      pesticides in environment        169

   Need for assessment of rates
      of accumulation in environment  174

   Ammonium ion, accumulation in
      soil                            206
  Oysters,'accumulation of DDT       208


                                     210
Residue accumulation in fat,
   fishes
   Wild mammals, accumulation
      of pesticides                    213

   Of pesticides in environment         245

   Of DDT ditldrin in fat of
      workers                        383

   Methoxychtor, little tendency
      to accumulate in fat, normal
      conditions                      430

   DDT, storage in fat, animals,
      humans                        435
     .' •*.
   Acetylcholine, at NMJ, in
      pesticide poisoning              452

   Effects over extended periods
      of exposure, carcinogens         464
  Interaction, effect on - • •>«
      storage of pesticides
                                  526
  Residue accumulation in body _
      tissue, time of exposure   ' "•
      to material       -            538

ICUTE
  Organochlorines, potential for
      •cute toricity           "        34
  Organophosphates, acute toxicity    34

  Effect of dietary protein on
      •cute toxicity                   36
                                             Toxich) of DDT substitutes         48

                                             Co. ^c; herbicides, acute
                                                effects                         67

                                             Zectraii, acute oral toxicity,
                                                in comparison with DDT         111

                                             Effects of pesticides on fish          210

                                             Human exposure, acute poisonings   231
                                             Organochlorines, potential for
                                                acute toxicity
                                      233
     Organophosphates, acute poisoning  234
     Improper storage of pesticides,
        acute poisoning                 234

     Influence of diet on acute
        toxicity                        235

     DDT, acute effects of              246

     Poisoning                         251

     Toxicity, terminology,
        definition                      259

     Epidemiology of acute
        pesticide poisonings             305

     Agent factors, contribution to
        acute pesticide intoxication      307

     Acute oral toxicities, LD-50         312
     Acute dermal toxicities, LD-50      312
     Phosphate ester pesticides           312

     Acute oial toxicities, LD-50         313
     Acute dermal toxicities, LD-50      313
     Chlorinated  hydrocarbon
        pesticides                      313

, ,   Organophosphates, occupational
        exposure, acute poisoning        347

     Acute pesticide exposures.
        Organophosphates               355

     Oinical signs of acute
        pesticide intoxication            358

     Acute effects of chlorinated
        insecticides, Organophosphates,
        and carbamates on mammals     359
     Chlorinated hydrocarbons, acute
        eiTecti                         !<9
                                                                                  77

-------
                                    SUBJECT INDEX
    DDT poisoning, effects
359
   Organic mercurial compounds,
      acute human poisoning          362
   Inorganic arsenical poisoning,
      acute                          362

   Chlorinated phenols
      pentachlorophenol, acute
      dermatitis                      364

   Organophosphatcs, acute
      poisoning, humans              367

   Organophosplioms compounds,
      production of acute toxic
      myocarditis                    371
   Yellow phosphorus ingestion,
      cirrhosis of the liver,
      acute poisoning                 371

   Organophosphorus compounds,
      effects on genito-urinary
      system                         373
   Toxicity of pesticides

   Poisoning, humans
382

383
   Organophosphates, acute
      toxicity, plasma cholinesterase    388

   Organophosphates, effect on
      alertness, acute poisoning        389

   Exposure, humans                 392

   Needed population studies on
      persons with acute toxicity
      episodes                       396

   Techniques of observation,
      LD-SO in skin vs parcnteral       402

   Poisonings of humans through skin   404

   Behavioral effects of pesticides       406

   Poisoning, terminology              407

   Behavioral effects of pesticides       408

   Studies needed  to measure
      behavioral effects, doses
      below acute toxicity             409

   Orbaryl, acute  doses, behavior
      vs catechohmines               410
 Chlorinated Hydrocarbons,
    occupational exix>suies          4i 1

 Echothiophate iodide, effect on
    red cell cholinesterase,
    compa-uon with pesticide
    exposure                       412

 Metaisosystox, acute symptoms
    of organophosphate poisoning   414

 Occupational exposure, signs and
    symptoms of acute poisoning    415
           Pesticide poisoning, brain
              anoxia, acute intoxication
                                  416
Baygon, ac>;'. .*. effects, humans      417
Studies in children after
   acute CNS poisoning            417

Organophosp  *te poisoning,
   behavioral fleets               418

Oganophosph. <•$, behavioral
   effects, acute poisoning          419

Correlation between acute
   toxicity, animals, occupational
   hazards, humans                423

Toxicity of Organophosphates
   vs acute toxicity of
   chlorinated hydrocarbons        424

DDT, acute effects of               425

Oral toxicity of 16
   antichofinesterase                   •
   insecticides, rats                427

Oral toxicity of DDT, rate           428

Toxicity, DDT, rats, carbon-
   tetractiloridc induced liver
   damage                        430

Diagnosis of poisonings, phenols
   vs cholinesterase inhibitors       450

Poisonings by pesticides             454

Toxic effects of EPN and
   malathion                      512

Organophosphates, administered
   to mice at 1/5 acute LD-SO,
   effect on enzyme induction      518
78

-------
                                    SUBJECT INDEX
   ODT poisoning, use of
      phenobaibital in                529

   Low protein diets, rats, effect
      on acute toxic effects of
      pesticides                     532

   Toxicity, pipetonyl butoxide       542

   Toxicity, Freons                  545

   Toxicity. Freons, effect of
      pipeionyl butoxide on          546

   Studies, chromosome effects        590

   Study, mutagenic thresholds
      of TEPA, METEPA             598

   Toxicity of captan, effect
      of protein on                   664

ADI
   Acceptable daily intake,
      pesticides                     137

   Acceptable daily intake,
      organochlorines                374
   DDT in human milk                374

ADiPOSE
   Accumulation of persistent
      pesticides in, occupational
      exposure vs general
      population                     153

   Present in adipose tissue.
      in comparison with other
      foreign material                248

   Organochlorines in general
      population                     255
   DDT, presence in human adipose
      tissue                         255

   Terminology, "persistence"         260

   HEOD in adipose tissue, humans,
      vs. daily intake                 265

   Concentrations in adipose tissue,
      use as indices of total body
      burden, exposure               273


   Storage of DDT in, vs daily dose    276
   Decline of HEOD in, rats, during
      post exposure period
292
 Dieldrin concentrations in,
    hununs                       301

 Relationship to daily dose and
    concentration in adipose
    tissue                          302

 Surveys of pesticides in             320

 DDT. DDE levels in                321

 DDT residues in, sex
    differences                     322
 DDT residues in. ethnic studies      322

 DDT residues in. age differences     323

 DDT residues in, place
    variables                       324

 DDT, DDE residues in Alaskan
    eskirnos                        326

 DDT in adipose, diseases            329

 Human monitoring survey, levels
    in adipose tissues                331

 Adipose residues, VJS., human
    monitoring data   '"            332

 Total DDT in, effects of age         335

 DDE levels in, by age, race          337

Total DDT, dicldrin in, humans      338

Total DDT. dieldrin in. humans      339

Residues of p,p'-DDE, diddrin,
   total DDT, humans              340

Residues of p,p '-DDE, diddrin,
   total DDT. humans              341

DDE, fed to-rats, monkeys,
   storage of in adipose tissue      427

DDT, DDR, dieldrin storage in
   males,  i females               429

Cachexia, effect on levels of
   pesticides in                  . 496

DDT. diddrin, heptachlor. rats,
   effect on storage               527

DDT in retarded, non-ambulant
   patients                       529
                                                                                 79

-------
                                   SUBJECT INDEX
   Levels in other tissue? in
      comparison with adipose         536

   DDT, exposure, storage of in        537
   DDT, residues of DDT, DDE in
      humans, household exposure     537

   DDT. DDE residues in,
      occupational exposure vs.
      general population              538

   Dieidiin levels in, rats              539
   DDT residues in, beef steers         539
   DDT residues in, dogs              539

ADRENAL
   Use of DDD to control adrenal
      overproduction                 300
   o.p'-DDD, atrophy of adrenals in
      dogs                          300
   Effect of DDD on man,
      other species                   300
   O.p'-DDD, effect on adrenals
      tn roan
301

435
   DDT, atrophy of adrenal cortex
   DDT, storage in adrenal gland,
      «titm«U                       435

   Need for more studies on
      enzyme induction              510

   Need for studies on enzyme
      induction in various species      520

ADSORPTION
   Reduction of pesticide levels
      in water by adsorption on
      activated carbon               123
   Removal of toxaphene and BHC
      from water by adsorption
      on carbon                     123
   Removal of pesticides fron water   123

   Pesticides analyzed from water
      samples adsorbed by carbon     129

   Factors to consider in reducing
      hazard of soil contamination     143
   Pesticide adsorption and
      sofltype                      143

   Soil moisture and temperature,
      effect  on adsorption of
      pesticides in sofl               144

   Pollution  hazard; reduction of      192
            Skin adsorption annual intake
               of DDT plus DDE               384

         ADULT
            Mosquito control, use of
               malathion, naled       ..        54

            Insect development, relationship
               of "juvenile hormone" to        83
            DDE Mood levels, humans,
              adults vs children
                                  148
Humans, accidents, occupational
   exposure                      157

Poisonings, humans, etiology        158

Insect control, injection of
   adults with juvenile hormones    165

Mosquito control, approaches to    196

Lake trout, DDT. DDE in          209

Insect control, developmental
   phcromones                   219

Volunteers, humans, information
   on pesticide*                   260

Poisoning cases, occupational
   exposure       '              306

Population groups, pesticide
   poisonings                     308

Population groups involved in
   poisonings                     356

Exposure to pesticides             395

Behavioral effects of
   pesticides                      407

Acute oral toxjcity of 16
   antichofinesterasr
   insecticides, weanling
   vs adult rats                    427

Parathion, administration to
   volunteers                     428

Mouse, newtocm, young vs adult     484

Radiation exposure, rats,
   young vs adult                 533
80

-------
                                    SUBJECT INDEX
ADULTICIDE
   Persistent insecticide use
      patterns                        48
   Mosquito control programs          48

   Mosquito control                   127
   Adulticiding operations,
      equipment used                 127

ADVERSE
   Develop regulations for
      collection and disposal of
      pesticides, containers, to
      protect public                   18

   Effects on environmental
      processes                       25

   DDT studies, not produce
      adverse effects                   34

   Effects in animals, humans,
      minimize exposure to            36

   Reporting of effects on humans,
      animals, wildlife                 51
   Population densities, effects of
71
   Effects on biological controi,
      from widespread use of broad
      spectrum pesticides              82

   Accidents, adverse effects          113

   2,4 D; effect on mosquito
      larvae, aquatic fauna            126

   Effects on environmental
      processes                      179

   Herbicides, persistence,
      effect on crops                 204

   Wild mammals, effects of
      pesticides on                   213

   Fertilizers, effects on spider
      mites                          218

   DDT, exposure of human population
      to, not produced adverse effects
      in volunteers                   233

   Minimize exposure of humans,
      while testing undertaken         235

   Registration of new pesticides       238
Acceptable daily intake,
   safety factor                   249

"No effect" level                  260

DDT, studies in volunteers          296

Lor.g term exposure to
   pesticides                      345

DDT exposure, occupational, no
   adverse effects, humans          348

Chlorinated hydrocarbons           350

Biochemical parameters             351

Recommendations for prevention
   of advene effects               355

Behavioral toxicity                 407

Psychiatric drug literature           408

DDT. long-term exposure,
   little effect                     471

Genetic effects                    598

Embryotoxicity, reproductive
   effects equated with
   tcratogenicity                  663
           Tes'ingfor
        AERIAL
           Sprtying, conditions, needs
           Dispersal of particles during
              aerial application
                                  668
           Chlorinated hydrocarbons, study
              on reproductive effects of
              DDT. humans                  674
                                  23
           Research and development needs,
              conditions suitable for
              spraying                        24

           Oils, use in aerial applications        62

           Spraying, conditions, needs          102

           Research and development needs,
              pesticides, aerial treatment        105
                                  107
           BHC, DDT. aerial vg surface
              application of                  108
                                                                                  81

-------
                                    SUBJECT INDEX
   Application of TEPP. effects of      110

   Application of endrin,
       concentration in pond           120

   Pesticides in human populations,
       aerial spray pilots               172

   Farm use of pesticides, aerial
       application, effectiveness        195

   Application of pesticides,
       commercial applicators          197

   Granules, application of by
       aerial or ground equipment      199

   Equipment available, need for
       further research                201

   Licensing of commercial
       operators                      221

   Accident rate for aerial
       appliers vs commerciiJ pilots     445

AEROSOLS
   Pyrethrin and allethrin
       formulations                    62

   Aircraft*, use of to apply            105

   Formulations of  pesticides          108

   Shelf paper, impregnated with
       pesticides, hazards              146

   Household aerosols, inhalation
       by humans                     201

   Ingestion of pesticides, routes
       of entry                       263

   Exposure to DDT,  inhalation,
       effects, humans                296

   Chktrthkm, aerosolized, routes
       of exposure, humans            445

   Protection of respiratory system
       from pesticide aerosols          446

   Information needed on
       inhalation of  aerosols            511
   Pyrethrum sprays, effect on
      liver, rats                      545
   Testing, need for reflecting
      routes of human exposure,
      aerosols                        567

   Testing needed for human
      exposure to aerosols             602

   Household pesticides, aerosols,
      need for testing                 611

   Product form, aerosol(A)            645

   Need for testing, inhalation
      of aerosols                      657

AGRANULOCYTOSIS
   Lindane, implicated in
      henutologic disorders            372
   Agranutocytoss, ucith rates
      1949-1958                      372

AIR
   Distribution of DDT and
      metabolites in                   9
   Residues of persistent
      pesticides in                     9

   Pesticide Advisory Committee,
      provide advice on standards and
      tolerances of pesticides in air      12

   Prevention of residues in vt          13

   Route of application,
      distribution                     22

   Dispersal of pesticides by            25

   Exposure to, of chemicals in         32

   Mercury, escape into air by
      volatilization                    45

   Interest in air pollution,
      persistence                      79

   Route of application.
      distribution                     101

   Movement of pesticides in            105

   Microdimatology effect             107

   Pesticide formulation, particle
      size, concentrations of
      DDT.BHCin                   108

   Drift of pesticides in                109
82

-------
                                 SUBJECT INDEX
TEPP, application of. air
    conditions
                                  110
Pesticides in. from
    agricultural use                 113
Transportation of pesticides in      113

Inhalation of DDT in, humans      114

Persistence of pesticides in          US

Drift of pesticides in               132

Exposure of humans to pesticides,
    foods vs air or water routes      .38

Volatilization of, into air            143

Wind erosion, residues in,
    transportation of               145

Concentrations of ttndane in
    home vs. manufacturing plants   149

Compressed air for occupational
    exposure, facemasks            151

DDT, hazard from indoor vs
 .   outdoor exposure               1SS
Concentrations of parathion
    over crops                     156

Air-radiation produced
    sterility, insects                 164

National Air Pollution Control
    Administration,
    responsibilities                 168

Monitoring program needed to
    study levels of pesticides
    in air                          169
Pesticides in
172
Techniques for measuring
   pesticide levels in, vs.
   food, water                    173

Sensitivity of method, limited
   by amount of air sampled        174

Movement of pesticides in           175

Diagram, movement of
   pesticides in                    176

Dispersal of pesticides by            179
            Leakage of pesticides into          192

            Application of pesticides by,
               amount reaching soil            195

            Adult nosquito control,
               con:amination of air            197

            Drift cf small particles in           201

            Exposure of humans to other
               chemicals in                    231

            Data needed for specific media      237

            Absence of data on natural
               carcinogens, mutagens,
               tcratcgens in                    262
           Effluents, improved technology      308


                                             326
   Sampling techniques for
      residues
           Gentian violet dust in,
              conjunctivitis, nosebleeds
                                    368
   Agricultural application of
      pesticides                      384
   Annual intake DDT, DDE
      estimates for                   384

   Parathion in, exposure to,
      humans                       402

   Kerosene, Xylene in,
      effects from                   417

   Accidents, agricultural
      applicators vs airplane
      pilots, commercial              445

   Simultaneous exposure to many
      chemicals, including air
      pollutants                      525

   Needed study, piperonyl butoxide
      interaction with air pollutants    541

   Chemicals in, tested for
      mutagenicity in mice            598

   Ethylene oxide in, tested for
      mutagenic effects,
      chromosome effects            640

AIRCRAFT
   Application of pesticides by
      aircraft                        105
                                                                               83

-------
                                     SUBJECT INDEX
    U«e in applying pesticides           105
    Aircraft, effect on pesticide
       spraying                       105
    Effect of aircraft on
       dispersal of pesticide            105

    Use of, for pesticide spraying        106
    Effect of aircraft on
       pesticide distribution            106
    Pesticide application, airplane
       vs helicopter                    106
    Helicopter, advantages over
       other aircraft                   106

    Drift potential                     109

    Mosquito control, application
       of oils                          127
    Adutticiding operations             127

 AIRPLANE
    Use of, in application of
       pesticides                       105
    Type of plane vs efficiency
       of application                   105

    Airplane, spray pattern from
       vs that from helicopter           106

    Hazard fiom DDT, household
       vs airplane dusting              155

    Potential exposure for
       workers, airplane containing
       TEPPdust                      156

    Behavioral effects of pesticides       406
    Pilots, complaints from
       application of pesticides         406

 ALBUMIN
    Serum albumin, in occupational!/
       exposed persons                 351

    Albuminuria, present during
      • poisoning, organophosphates     373

 ALERT
    Concern, ilerted by reports
       of robin mortalities              210

    Neurological abnormalities           389
    Mental alertness, occupationaHy
      exposed persons vs controls       389
    Mental alertness, in acute
      poisoning                       389

    Mental alertness, occupational
      exposure                       414
    In poisoning cases                  414

    Hazard to an plane pilots            445
    Pesticide intoxication               445

    Alertness by medical
       practitioner in recognizing
       cases of poisonings              661

ALFALFA
    Methoxychlor, use in alfalfa
       weevil control                   51

    Heptachtor, control of
       alfalfa weevil                    52

    Cotton pests, preferentially
       attracted to alfalfa               83

    Residues in alfalfa of aldrin,
       heptachlor                      132
    Residues in alfalfa of dieldrin        132

    DDT in alfalfa, residues in
       cowtmOk                      139

    Alfalfa, strains resistant
       to insects                       162
    ^mported parasites and predator?
       to control alfalfa wcivil          162
    Alfalfa, resistant to diseases          162

    Control of alfalfa caterpillar         163

    Control of alfalfa aphkl             168

    Endothall, pre and post
      emergence herbicide            648

ALGAE
    Need for more studies, pesticide
      residues on algal
      photosynthesis                   25

    Need for studies, residues on
      algal photosynthesis            103

   Marine algal •• ho tosyn thesis,
      inhibition by DDT              121

   Pesticides, use in swimming
      pools for algae control           146

   Need for observation of effects
      on algae                        205
   Indicator of ecological changes      205

   PhytopUnlcton                     207
   DDT, effect on algae               207
84

-------
                                    SUBJECT INDEX
ALKALOID
   Strychnine alkaloid, use as
      rodenticide                     72

   Alkaloids, tested for
      mutagenic effects               583
   Alkaloid* tested for chromosome
      abemtioru                    583

AL!ERGEN
   Patch testing                      398
   Patch testing with pesticides         398

ALLERGIC
   Allergic dermatitis, caused
      by pesticides, TEPP             364

   Allergic dermatitis in workers        365
   Phenolic derivatives                365
   Dermatosis, from organic
      mercurials                      365

   Allergic dermatitis in workers
      from pesticides                 399
   Specialists reports on
      potential health effects          399
   Allergic contact dermatitis,
      diagnosis                       399
   Allergic contact Jensitizzticn,
      due to 2-chk>to-N-diaDyl
      acetmide                      399
   Allergic contact sensitization
      in man                         399
   Interpretation of information        399
   Allergic contact dermatitis,
      information                    399
   Allergic serialization potential,
      information needed             399

ALLERGY
   Natal allergy, exposure to
      pesticides                      149

ALOPECIA
   Hexachlorobenzene ingestion.
      from contaminated gain        364
   Permanent alopecia                3f 4

ALUM
   Water treatment                    122
   Arum coagulation, for removal
      ofpestkides                    122

   Water featment                    123
   Ahim coagulation, for
      removal of pesticides (2,44))     123

ALUMINUM
   UK of aluminum foil in aphid
      control                        219
   Light reflections, physical
      methods of control     •        219

AMIDASE
   Studies needed to evaluate liver
      afiesteiase and amidase
      in nun                         510

   Degradation of dimethoate          514

ANALYSIS
   Continuous system for analysis
      of pesticides in environment
      needed                         23

   Of proposed pesticide
      characteristics, before
      application to tarpt  area         24

   Of food, for monitoring             36

   Of selected alternative methods
      of pen control                  57

   Systems analysis of pesticides
      in the  environment               101

   Of proposed pesticide
      characteristics, before
      application to target  area         103

   Of well water, chlordane in          117

   Problems of sampling, analysis       118

   Of proposed pesticide
      characteristics, before
      application                     126

   Crops, study of residues,
      dafly intake                     135

   Continuous analysis of data,
      benefits                        170
   Soil samples analyzed               170

   Analytical methods,
      interpretation of results          172

   Of pesticide residues in food         173

   Systems analysis of pesticides
      in the  environment               174

   Establish  priorities for
      research, methods of sampling
      and analysts                    238

   Pesticide protection teams,
      collection of appropriate
      samples for chemical analysis     241
                                                                                  85

-------
                                    SUBJECT INDEX
    Analysis of tissues for DDT,
       humans                       2SS

    Source of error in analysis
       of DDT and related materials     257

    Of environmental samples          258

    Pesticide poisonings,
       unsuspected, until chemical
       analysis performed             306

    Of human milk for DDT            373

    Errors in data analysis              387

    Standards for food sampling and
       pesticide analysis needed         395

    Of accidents, aerial
       applicators w airplane pilots      445

    Of urine, for chemicals             448

    Statistical analysis of results         481

    Statistical analysis of data,
       humans, interpretations          536

    Of bile, metabolites of MDP
       compounds                    547


    Genetic analysis of Neurospora
       mutants                       573
    Chromosome aberrations, analysis    577


                                     578
Specific-locus method
   (waxy locus) in pollen
   Data analysis, need for
      piompt reporting and analysis   601

   Statistical analysis                667

 ANALYTICAL
   Methods, need for further
      development                   24


   Methods, need for further
      development                  102


   Needed improvement in
      analytical methods for
      monitoring pesticides           170

   Methods                         172
                                            Procedures, to detect
                                               contamination of treated seed
                                               grab with untreated             200

                                            Complexities, sources of error
                                               in analysis                      257

                                            Methods for various. chemicals       319

                                            DDT in human milk, differences
                                               in analytical methods            374

                                            Methods for chlorinated
                                               hydrocarbons, blood,
                                               development of                 448

                                            Methods, detection of DDT
                                               in diet                         472

                                        ANAPHYLAXIS
                                            Need for determination of
                                               effects, direct toxicity,
                                               allergy or anaphylaxis            455
   Aplastic anemia hazards,
      consideration of                261

   Aplastic anemia, lindane           352

   Aplastic anemia, deaths
      1949-1958                     372
   Discussion of results               372

   Aplastic anemia from
      chlordane, gamma benzene
      hexachloride, parathion         388

ANESTHESIA
   Barbiturates, short acting for
      anesthesia                     425
   Control of CNS hyperactrvity       425

ANOMALY
   Congenital, recording of
      at birth                       6UO

   Ousters of. interpretation of        663

   2,4,5-T in DMSO, production of
      anomalies                     666
   2,4,5-T; incidence of
      kidney anomalies               666
   Cubaryl plus piperonyl
      butoxide, incidence of cystic
      kidneys                       666

   Fetal anomalies, statistical
      analysts                       667
86

-------
                                     SUBJECT INDEX
    Pesticides yielding anomalies,
       mice                          668

    Increase of anomalies, mice,
       compounds tested              670

    Increase of anomalies, mice,
       compounds tested              671

    Increase of anomalies, mice,
       compounds tested              672

    No increase of anomalies, mice,
       compounds tested              673

    No increase of anomalies, mice,
       compounds tested              674

 ANOXEMIA
    Uve of oxygen or artificial
       ventflation in                  450

 ANOXIA
    Organophosphatej, health
       hazards                       347
    Anoxic sequelae                   347

    Oiganophosphorus compounds      372
    Liver damage vs anoxia             372

    Brain anoxia from respiratory
       failure                         416
    Acute poisoning                   416

    Ingest ion of piperonyl butoxide,
       production of anoxia            542

 ANTS
    Use of aldrin for                   51

    Control by commercial pest
       control industry                53

   Ants, use of DDT for               54
   Fire-ants, use of Mirex for           54

   Fire-ants, use of organochlorine
      pesticides in quarantine
      programs                       55

   Use of lead arsenate as baft for       62

   Use of chlordane for               151

   Control by commercial pest
      control industry                195

ANTAGONIZE
   Antagonistic interactions,
      lack of knowledge of             81
    Antagonistic interactions,
       between dieldrin and DDT
       in fatty tissue storage            81

    Antagonistic interactions,
       between pesticide residues
       and drug response               82

    Antagonism mechanisms, use of
       dimeraprol (BAL) for dictation
       and removal of arsenic and
       mercury from body tissues      452
    Antagonism mechanism, v  • of EDTA
       and pcmcQlamine in he. try
       metal poisonings               452
    Antagonist of poisoning, use v '
       atropine for cholinesterasc
       inhibftoii, such as carbaryl      452
    Antagonist, competitive,
       atropine and acetylcnoline      452

    Antagonizing muscle paralysis
       caused by cholinesterase
       inhibitors, use of oximes for,
       such as 2-PAM Cl, or Toxogonin  453

    Antagonists, use of oximes for
      organophosphonis insecticides
      and miticides                   454
   Antagonizing by
      tetraethylammonium chloride
      in caitwmate poisonings         454

    Antagonism in the action of
      one enzyme upon two substrates 524

   > itagonistic effects on
       autagenesis                    598

ANTIBIOTIC
   For controlling plant diseases       66

    Antimycin as a fish toxicant        73

   For controlling plant diseases       203

   Antimycin A as a pisicide   ;        213

   Resistance to antibiotics.
      mutations                     572

   Antibiotics, tested for
      mutagenk effects               583
   Antibiotics, tested for
      chromosome aberrations         583

   Griseofulvin, may inhibit DNA
      synthesis                      609
                                                                                 87

-------
                                   SUBJECT INDEX
ANTIBODY
   Pesticides, potential health
      effects                        398
   Allergic contact dermatitis          398

ANTICHOLINESTERASE
   Effects of anticholinesterase
      on the nervous system           3S9

   Behavioral effects of
      anticholincsterase compounds    408

   Altered behavior due to
      anticholinesterase               410

   Behavioral changes, humans, from
      anticholinestense
      administration                 411

   Insecticide poisoning, human,
      signs                          412

   OccupationaLexposure, Baygon,
      anticholinestense poisoning      417

   Oximes, use in treating
      poisoning by anticholinesterase
      compounds                    453

   Tetraethytammonium chloride,
      not used to treat
      anticholinesterise poisoning,
      humans                       454

   Needed studies on inhibitory
      action of anticholinesterase
      pesticides on ahesttrases         510

   Needed studies on inhibition of
      plasma and liver
      atiesterases                     513

   Needed information on effect of
      all anticholinesterase pesticides
      on aliesterase  activity           515

   Enzyme induction, effect on
      toxicity of
      intkholinesterases              518

 ' Malathion, in vitro
      anticholinesterase activity       524

   Insecticides, banol, parathion,
      effect of low protein diet
      on toxicity                    532

ANTICOAGULANT
   Anticoagulant rodenticides         72
   Uv- in controlling rodents           72

   Us? as rodenticides                181

   Rodenticides                      214
   Toxicity to cats                   214

   Pesticides in use                   446

   Rodenticides                      451
   Therapy for poisoning              451

ANTICONVULSANT
   Effect of anticonvulsant drugs
      (phenobarbital and
      diphenylhydantoin) on DDE
      blood levels, humans            436

   Effect of repeated administration
      on body burden of chlorinated
      hydrocarbon insecticides         451

   Effect of phenobarbital and
      diphenylhydantoin on DDE
      blood levels                    529

ANTIDOTE
   Antidotes for organophosphorus
      compounds                    361

   Use of atropine, oximes in
      humans, animals                426

   Vitamin Kl.antLote
      for hemorrhagic effects          451

   Phenobarbital, antidote for
      »cute DDT poisoning            529

   Radiation                         533
   Effect of x-irradiation
      and organophosphate
      insecticides                    533
   Use of atropine in poisoning         533


ANT1FOULANTS
   Use in paints and  coatings          197


ANT1IUNGAL
   Grfeeofuhrin, antifungal
      antibiotic                      546
   Enchancement of toxicity
      with other compounds          546


ANTntALARIAL
   Antimalarial spraying               356
   Organochlorines                   356
88

-------
                                    SUBJECT INDEX
ANTIMICROBIAL
   Antimicrobial action, related
      to molecular composition        66
   Classification, based on
      chemistry                      66

ANTIMITOTIC
   Effects, bibliography on            613

   2,4,5-T; slight effect               642

ANXIETY
   Experimental dermal
      exposure to DDT              296

   Effects of organophosphoroiis
      insecticides on pilots            414

APHID
   Pesticides before 1945              44
   Ground tobacco used in France,
      in 1763 to kill aphids            44

   03s, used to control aphids          62

   Cotton oops, use of chlorinated
      hydrocarbons to control          84

   Control of spotted Mphalfa
      tphid                         168

   Central of aphids with light,
      aluminum foil                 219

   Endrin, control of pests            648

   Parathion, control of pests          652

   Phospharaidon, control of pests     653

APLASIA
   Marrow apUsia. radiation
      exposure                  -^  255

APLASTIC
   Aplastic anemia                    261
   Hazards                          261

   Lindane                          3S2
   Apbstic anemia                    352

   Lindane                          372
   National death rates,
      aplastk anemia                 372

   Blood dyscrasias                   388
   Aplastic anemia aoodated
      with chlordane, gamma
      benzene hexachloride and
      parathkm                      388
 APNEA
   Use of oxygen or artiflcial
       respiration                    450

 APPETITE
   Chronic exposure, pesticides,
       fish                           210

   Chronic arsenical poisoning,
       effects hu.itans                 362

 APPLE
   Use of insecticides on              47

   Carbaryl, use on                   104

   Malathion residues on,
       food processing                141

   Synthetic juvenile hormone,
      control of codling moths in
      apple trees                    165

   DDT, for control of apple
      pests, effects on beneficial
      insects                        207

   Red mites, cfuct on apple trees     208

   CapUa, occupational dermatitis
      apple spraying                  365

   Chloro-2 phcnylphenol, sodium
      orthophenyl phenate,
      dermatitis, conjunctivitis
      in apple sorters                 368

   Sodium chtorophenylphenate,
      effects in apple sorters          373

   Leucopenia in apple growers        389

   Hazards of current pesticide
      use. If ucopcnia in apple
      growers                       392

   Occupational exposure, in
      apple orchards                  415

   DDT exposure, humans,
      spraying apple trees             445

   Lindane, use fot apples             650

APRICOT
   2,4,5-T; tested on. effects          642

AQUATIC
   Distribution of DDT in
      aquatic organisms               9
                                                                                 89

-------
                                   SUBJECT INDEX
   Use of in aquatic areas,
      precautions

   Fenac, use of in aquatic
      weed control

   Use of in aquatic areas,
      precautions
   DDT, fate in aquatic systems
   2,4-D application, effects on
      aquatic fauna
   Dinoseb. hazardous to aquatic
      organisms

   Diquat, aquatic herbicide.
      toxicity

   Dkt of aquatic species

   Toxaphene. toxicity to aquatic
      buna

   Mictofomal enzyme activity.
      Differences between aquatic
      and terrestrial animals
                                  24
                                  68
                                  103
   Treatment of lakes with
      toxaphene, effect on
      aquatic life                    119
   Possible buildup of pesticides
      in lakes, effects on
      aquatic organisms              119
                                  120
   Endrin, spraying of fields,
      concentration in aquatic biota    125
                                  126
   Municipal and industrial
      waste discharges, treatment
      to reduce toxicity to
      aquatic systems                127

   Program to determine
      pesticide levels in
      aquatic animals  "             170

   Minimizing hazards to aquatic
      environment                   196
                                    200
Application of pesticide
   granules, exposure of
   non-target organisms    -

Pesticide surplus, routes of
   entry into aquatic
   environment                   202
                                 203


                                 205

                                 208

                                 s
                                 213



                                 436
   2,4-D; use to control aquatic
      weeds                        646

   EmlothaU, aquatic herbicide        648

   2,4,5-T; use to control
      aquatic weeds                 6»3

ARMYWORM
   Cotton pests, chlorinated
      hydrocarbons                  84

   Rice                             85
   BHC, to control armyworms         85
   DDT, to control armyworms         85

   BHC, control of armyworms         87
   Potatoes                          87
   DDT, control of armyworms         87

   Sugar beet                        88
   BHC, to control armyworms         88

   Oilseeds                          90
   Toxaphen->. control of
      armyw..rms                     90

   Endiin, to control pests            648

ARREST
   Organophosphorous compounds,
      cardiac arrest                   371
   Cardiac arrest after paraquat
      ingestion                      371
   CarJac arrest, sodium
      Ouoroacetate (1080)            371

ARRHYTHMIAS
   Cardiac arrhythmias               360
   Poisoning due to organopnosphatcs  360

ARSENICAL
   Arsenical, Paris Green, use
      V 1865 against potato beetle     45

   Inorganic .useni^als, effects
      on nervous system             362
   Acute inorganic arsenical
      poisoning                      362

   Arsenical insecticide*.
      occi' national expos ire         363
   EKG changes from                363

ARTHROPP"                        m
   Marine it.'. rtebrates              208
   Shrimp, crabs, zooplantton
      sen jtive to chemical poisons     208
90

-------
                                  SUBJECT INDEX
   Juvenile hormone of arthropods     219
ASBESTOSIS
   Mesothdioma, complication of
      pulmonary atbestoib

ASPARAGUS
   Monuron; for control of weed
      aecdttngs in asparagus

   Simazine, control of pines
      and broadleaf weeds in
ASSAY
   Quality control assays, needed
      for pathogens in control
      programs

   No a: Jay of interim effects
      of materials on tissues

   Of importance of MDP synergists

   Mutation testing. Neurospora

   Reverse mutation induction

   Specif c-locus method (waxy
      locus) in pollen

   In vivo assays, advantages

   Host-mediated assay, for
      detecting mutagcnic
      compounds

   Induction of dominant lethal
      mutations in animals

   Domi tant lethal assay
                                    253



                                    65 1



                                    653




                                    61


                                    487

                                    554

                                    573

                                    574


                                    578

                                    589



                                    594


                                    596

                                    597
   Mammalian tests for evaluating
      potential mutagenic compounds 602

   Assay system, mutagrnicity
      testing                       639

ASTHMA
   Asthma, household pesticides       149

   Asthma, pesticide exposure        352
   Parathion. asthmatics,
      discussion of results            352

   Organophosphorus compounds,
      cause or exacerbate bronchial
      asthma             .         369
   Asthma, exposure to
      houKhola insecticides

ATMOSPHERE
   Survival of pesticides,
      photochemical reactions
   Atmospheric contamination by
      pesticides

   Pesticides in atmosphere as
      partkulates
   Presence in air, dependence
      uponfactou

   Persistent pesticides in Marine
      environmef.t, long-term
      impact on atmosphere-

   Insect fungus disease*, effect
      of moisture, temperature on

   Presence of many compounds in
      air. analysis

   Environment

   Fumigantj, escape into
      atmosphere

   Aerosols, contamination of
      the atmosphere

   Fhytopbnkton, production
      of oxygen

   Agricultural areas, population
      exposure from spraying

ATROPHY
   Atrophy of adrenals, o.p'-DDD

   Skin atrophy, hexachlorobenzene

   Atrophy of adrenal cortex. DDT

ATTRACTANTS
   Chemical attractants

   Pherornones, other insect
      attractants

   Metaldehyde, use as slug
      attractant

   Chemical attractants, uses

   Pest control

   Use of infrared light sources
 370



 113

 113


 114

 114



 121


 163


 173

 186


198


201


207


538


300

364

435


 60


 61


 73

 75

164

166
                                                                               91

-------
                                     SUBJECT 'NDEX
 AUTONOMIC
    Autonomic dystonia, DDT worken  409

 AUTOPSY
    Pesticide deaths, diagnosed at        306

    DDT, dieldrin, analysis of
       samples, ethnic differences       322

    Cases, tissue residues,
       pathology                      328

    Pesticides in body tissues            385

    HepUchtor. dieldrin in
       autopsy tissues                 386

    Pesticide levels, pathology,
       autopsy tissues                 391

    Studies, negative evidence,
       hazards of                      392

    Malignancies, autopsy
       material                        394

    Malignancy, pesticides, autopsy
       material                        395
   Oiganochlorincs in humans,
       vs controls
   Dominant lethal assay

AUXINS
   Synthetic auxins
   Use rates
   Uses
AVICIDE
   Avicides, uses

   Aricidcs, uses
   Avicides, hazard to desirable
      species of birds

AXON
   Axonic agent, e.g. chlorinated
      hydrocarbons
   Hyperexcitability of axon
495
   Pesticide monitoring program,
       samples obtained by            496
597
 74
 74
 74
   Hormone (auxin) analogs           604
   Presumed major mode of action     604
   Not suspected to produce
      genetic alterations
605


 73

214

214
524
524
         riACTERIA
            Pesticide, definition,
               exclusion of                    24

            Microbtal control cf insect
               pests, use of                    60

            Bactericides, toxicrty to             65

            Antibiotics, use of                  66

            Diseases, precautions, effects on
               non-target, beneficial species      82

            Breakdown of chlorinated
               hydrocarbons vs
               organophosphates. by bacteria    143

            Insect pathogens                   163
            Use for control of Japanese
               beetle                         163

            Concentration of pesticides by       169


                                             186
   Breakdown processes of
      environment
   Application of pesticides to
      final products to prevent
      attack by                       197

   Antibiotics, use in control
      of plant diseases                 203

   Pathogens, use of, to control
      insects                         216
   Control of Japanese beetle           216

   Control of pest caterpillars           217
   Specificity of pathogens             217

   Captan, mutagenic effects in
      bacteria                       438

   Bacterial methods, point
      mutations                     572

   Phagc and transformation          574

   Plant chromosomes vs virus,
      bacteru                       575

   Host-mediated assay, use  of
      bacteria                       589

   Host-mediated assay                594

BACTF.RICIDE
   Bactericides, discussion of           65
92

-------
                                     SUBJECT INDEX
    Development of antibiotics as
       bactericides                     66
    Agrimytin, use as bacteritiJe         66

 BACTF.RIOPHAGE
    Pha^e and tiansfonnation phages    S74
    Baaeriophage T-4                  574
    Characterization of mutagenfc
       agents
    Lead arsenate, use in baits
       for ants, cockroaches
601
 BAITS
    Use of, for chemical attractants,
       chemosterilante                 60
62

72
   Inorganic rodenticides, use in
   Botanical rodenticides. use of
      strychnine in                    72
   Anticoagulant rodenticide:,
      use in                          72

   Metoldehyde in slug, snail baits      73

   Chemical attiactants, use in          75

   Kepone pellets, use to control
      rodents                        151

   Chemical attractants               164

   Use of light, to attract
      insects to chemical bait         168

   UK of chemical bait as avicide,
      effects                         214

   Actions to improve protection
      of public health                239
   Improve design and development
      of household bahs              239

   Warfarin bah. epidemics of
      poisonings                     311

   Uoach baits, substitution of
      equally effective, less
      toxic substances                356

   Thallium bait, poisoning
      of child                        363

   Application types (B)              645

BALD
   Bald cypress, planting of Uees
      on shorelines                   168
   Bald eagle, Decrease in numbers      211

   Bald eagle, decrease in numbers      437

BAN
   Grade IV pesticides, ban of
      nonessential uses               13

   DDT, banning of UK in U.S.         50
   Use in malarial control overseas      50

   Persistent insecticides, if
      banned, use of other compounds  51
   Dieldrin. heptachlor, banned
      in 1968
   Grasshopper control

   DDT, banning of all uses,
      discussion
              of or banning of

        BARLEY
           Losses due to insects
           Parathion in, epidemics of
              poisoning

           Mutation induction by seed
              treatment

           Specific-locus method (waxy
              locus) in pollen

           Pesticides known to produce
              mutations in
           Mutagenicity testing, atrazine.
             carbaryl

           Mutagenicity testing. DCNA,
             dicamba, endrin
91
91
                                            472

                                            478
  Carcinogenic pesticide, ban of
  Potential carcinogenic pesticide,
      considerations for banning of    478

  Discussion of banning pesticides     488

  Mutagenk pesticides, restriction
                                   567
                                    86
           Heptachlor, heptachlor epoxide
              residues in seeds, soil            133
           Aldrin. dieldrin, residues in
              seeds, soil                      133

           Development of resistant plants      162
                                   310
                                   576
                                   578
                                   584
           Pesticides producing mutations in   585
                                   639
                                   640
                                                                                  93

-------
    tiutagenicity testing. Isocfl

    Mutagenichy testing, tinuron,
       monuton

    Mutagcnictty testing. photpharaidon,
       simazine

 BATS
    Bats, control of, use of DDT

    Bats, control of, use of DDT

 BEAGLE
    Beagle dogs, fed carbaryl.
       effects

BEANS
   Red Mexican beans,
      2,4-D application to
   Tentative guidelines, Acrolein,
      furrow, beans
   Tentative guidelines, Acrolein,
      soybeans

   Beans, development of strains
      resistant to diseases

   Lindane, use on beans

BEDS
   Use of flolystream to control
      predatory snail in oyster beds

BEES
   Toxicity to bees, substitute
      chemicals
   Substitute chemicals, effects
      on wildlife, fish

   Juvenile hormone, effect on
      bees

   Carbaryl, effect  on bees

BEEF
   DDT-type residues in beef steers

BEER
   Beer cans, environmental
      poDution

BEETS
   Sugar beets
   Total insecticide usage
   Chlorinated hydrocarbons,
      usage on

   Sugar beets, chemicals to
      control pests
SUBJECT
641
642
643
48
54
664
124
124
124
162
650
72
49
49
83
208
539
220
84
84
INDEX
Sugar beets, lotses due to
insects
Tentative guidelines, Acrolein,
sugar beets
BEETLES
Paris Green, use against
potato bee tie
Aldrin, UK to control beetles
Organochlorines, use to
control beetles
Biological control, of
Japanese bcetk
Blister beetles, hazardous
compounds in
3HC, use to control rice pests
Vegetables, DDT to control
beetles
Potatoes, DDT to control beetles
Sugar beets, BHC to control
beetles
Sugar cane, BHC/Lindane to
control beetles
Tobacco, DDT to control beetles
Bacteria, for control of
Japanese beetle
Lady bird beetles, susceptibility
to DDT
Effects of pesticides on
beneficial insects
Control of Japanese beetle
Paradtchlorobenzene, use to
control beetles
Parathion, use to control
beetles
Phosphamidon, use to control
beetles

88
124
45
51
55
82
83
85
87
87
88
89
89
163
207
207
216
651
652
653
        BEHAVIOR
84        Organochlorines, effect on          33

          Uses of pheromones, insect
88           attractants                     61
94

-------
                                 SUBJECT INDEX
Chemical attractants,
   quantities needed for those
   associated with sexual
   behavior                       75

Induced sexual sterility             164

Radiant energy, effects on
   behavior, insects                167

Research directed toward
   bchaviur of persistent
   pesticides                      175

insecticides, effe cts in birds         212

.Repellents, effects on behavior
   of mammals                    215

Organochlorines, effect on          232

Research needs, studies on
   behavioral effects               240

Effects of pesticides                243

Dynamic.; of behavior of DDT,
   HEOD                         269

Model of behavior
   of organoihiorines               272

Behavioral effects of
   pesticides                      406
Behavior, definition                406

Behavioral toxicity                 407

Clinical behavioral toxicity          408

Behavioral changes,
   occupational exposure, DDT     409
Behavioral changes, cats, aldrin       409

Behavioral changes, monkeys,
   endrin                         410
Behavioral changes, rats,
   carbamates                     410

Behavioral changes,
   anticholinesterascs               411

Behavioral changes,
   organophosphates               412

Behavioral changes,
   organophosphates               413
Behavioral changes, DFP            413
   Behavioral changes,
      orgauophosphates               414

   Behavioral changes
      orgar.0 phosphates, chlorinated
      hydrocarbons                  415

   Behavior il chz.igcs, Baygon         417
   Behavioril changes,
      phosdrin/parathion              417
   Behavioral effects of solvents        417
   Behavioral tests                    417

   Behavioral changes,
      organophosphates               418

   Behavioral changes,
      organophosphates               419

BENIGN
   Benign tumors, evaluation of        4>i6

   Benign tumors, results of tests       4o7

   Benign and iraU^nant tumors        462
   Definition of "tumor" for study     482

   Benign tumors, induction of by
      chemical  agents                 488

BERRY
   Berry boxes, Dowcide-7 on          475

BEVERAGES
   Chlorinate 1 hydrocarbon
      pesticides                      136
   Dietary intake from beverages       136

   Chlorinated hydrocarbon
      pesticides in diet                138
   Residues, not in beverages    ,       138

   Chlorinated organic pesticides
      in diet                         385
   Not found in beverages              385

BILE
   Effect of pesticidal syrwrgists
      on bile acids                    543

   Determination of metabolites
      in rat bile                      547

BILIRUBIN
   DDT, use to  decrease serum
      bflirubin                        300

   DDT, used to treat biiruuiremia.     329
                                                                                95

-------
                                   SUBJECT INDEX
   Decreased plasma bilirubin. DDT
      admmistntion

BIOASSAY
   Bioassay of 2.4.5-T

   Bioassay, number of animals
   Discussion of result i

   Bioassays, interpretation
      of results
   Bioassays, extrapolation of
      animal data to humans
   Evaluation of carcinogenic
      hazard

   Food additives and contaminants
   Bioassay for carcinogenic hazard

   Bioassays, review of data
      by Panel
   Data elements acceptable to
      Panel

B1OCIDAL
   Biocidal materials, release into
      environment, need for reduction
      of

   Effects of biocides in ecosystem

   Mammalian biocides, and
      rodenticides

   Biocidal materials, release
      into environment.tieed for
      reduction of

   Effects of biocides in ecosystems

   Mammalian biocides and
,      tudentiddes

BIODEGRADAT1ON
   Biodegradatjkui, removal of
      contaminants from water

   Bfodegradation of carbonates
   Bxxlegradaiion of
      organophosphates

   Biodegradable compounds, use of

BIOMAGN1FICATION
   Registration of pesticides
   Bfomagiification, information
      needed

BIOPSY
   Biopsy of Mood or fat samples

329

204
465
465

466
466

466

467
467

468
A£O
468

26

29


71


ISO
183

214


192

525
525
542

238
238
Biopsy, analysis for
inethoxychlor
Pesticides in body tissues
Pesticides in fat
Biopsy, analysis for DDT,
dieldrin
BIOSPHERE
Pesticides distributed in
Needed studies to determine
pesticides in

rtsticides distributed in

Needed information on
pesticides in
Needed continuous assessment
of storage and rates of
accumulation in
influence of man on
Phytoplankton, effect on
BIOSYNTHESIS
Effects of pesticides on
biosynthetic processes,
needed studies

Biosynthesis of brain amines
BIOTA
Normal biotk community
Recycling of pesticides in
btotic systems
Spraying of pesticides.
effects on ronUrget biota
Pesticide concentration in
aquatu biota
Assessment of pesticide levels
in biota
Normal Motic community
Urban areas, damage of
pesticides
Pest control
Application by trained operators

301
385
385

430

22

23

101


16«


174
186
207



2<0

410

29

120

126

126

169
183

194
195
195
           Recovery of biota, between
255           applcatton*
196

-------
                                   SUBJLCT INDEX
   Decomposition of pesticides
      by soft biota
   Exposures to DDT, effect*
   Deaths in. from treated
      cereal seed dressings

   Deaths in

   Lady bird beetles, effect
      of DDT on
201
BIRDS
   DDT, metabolities distributed in     9
 25
   Avicides                           73
   Avitrol, to control                  73
   Quele'ox. to control                73
   Anthraquinone, to control           73
   Thiram, to control                  73
   Thallium sulfate, to control          73

   Mongoose, effect on                82

   Ultrasound, proposed use to
      control                         83

   ODD in                           127

   Exposure to DDT. effects           179

   DDE, effects on egg shell,
      reproduction                   189

   Pest control, effects on             194

   Control of pests of shade.
      ornamental trees, effects on      196
200

206


207
   DDE. effects on reproduction of    210
   DDT, cffecu on reproduction of    210
   Pesticides, effects on               210

   DDT poisoning in                  211
   Effects of insecticide
      residues in                     211

   Dieldrin. DDT in diet of,
      effects                        212

   Avicides                          214
   Hazards to nontarget
      organisms                     214

   Repellents, use to control           215

   Mongoose, efl cts on               216

   Organochlorines in eggs of          269
Ecological signals from             305

Adverse effects of pesticides
   in ptedator birds               357

Chlorinated hydrocarbons.
   effects in                      373

Rotenone, toxkity  to              426

DDT poisoning in, effects of
   starvation                     431

Chkninated hydrocarbons,
   effect on eggshell thickness      437
Decline in population of            437
           o,p'-Dt>T, effects in
           Birth defects, need for
              awareness

           DDT, effect on race and sex
              differences
           Physical abnormalities at birth
                                               Congenital malformations
        BLACKFLY
           Methoxychlcr, to control
              bbrkfiies
                                 665
        BIRTH
           Dieldrin, effect on birth weight
              fa deer                         213
                                 261


                                 386

                                 481
           Carcinogenic potential
           Administration of chemical
              after birth                     431
                                 570
Birth, reporting of abnormalities
   by physicians, specialists         600
Proportion of, with anomalies       600
                                            657
           Occurrence of malformations
              among births                  662
           Birth certificates, congenital
              malformations                 662

        BITTER
           Bitter taste, carbamates and
              dithiocarbamates               369
           Bxygon, bitter taste in mouth.
              occupational exposure,
              residents                      369

        BLACKBIRDS
           Avicides, use to control             73
           Troublesome species to control       73
                                 51
                                                                                 97

-------
    Blackflies, biting of humans

BLADDER
    Bladder carcirogenicity of
      aromatic amines

    Pathologic evaluation
    Urinary bladder, special
      techniques required for
      histological examination

    Pesticide concentrations in
      persons with carcinoma of

    Bladder cancer, increased
      incidence

BLIGHT
    Pesticides, use to prevent
      Nigtt
   Crop application

    Blight-resistant crop strains

BLINDNESS
    River blindness
   Spread by simulium fly
    Use of DDT to control

   Behavioral effects of
      pesticides
   Night blindness, airpbne
      pilots

   Pesticides, effects on eye

BLISTER
   Blister beetles, cantharidin from
    Hazardous compounds

   Blister beetles, control of
   Use of DDT, on potatoes to
      control

BLOOD
   DDT in, related to recent
      exposure
   DDE in, related to long term
      exposure

   Testing, preventive measures
   DDT, organochlorines in, limits

   DDE in, children
   DDT. DDE in. kittens

   Undane in, humans

   Composition changes in flsh,
      exposure to pesticides
SUBJECT
81



465

466

466

495

498



132
132

162

91
91
91

406

406

406


83
83
88

88


33
33
35
35
1 JtO
148
148
149

210
INDEX
DDT in, related to recent
exposure
DD£ in, related to long term
exposure

Tesring, preventive measures
DDY, organochiorines in, limits
Research need*, towering of
blood cbolinestense
Withdrawal of workers, blood
levels
Chemistry differences

Samples, obtaining, analysis
for DDT
Organophosphates in

Levels of pesticides in.
indicator of exposure

Levels in
HEODin

HECO in, rats, dogs
.HEODin

HEODin

HEODin

Model, transfer between
blood, tissues

p,p'-DDE in, humans
HEOD in body fat, rats,'
vs blood

HEOD in blood, liver, rats.
post exposure
HEOD in workmen, after
exposure terminated
Experimental oral exposure to
dieldrin, concentrations in
Dieldrin hi
Estimated half-life of
dieldrin in

Pestic&e levels in
DDT, DDE in. humans


232

232

234
2?4

240

242
254


255
255


260

254
265

266
267

258

270


272

273

.,285


293

294

301
302

302

320
321
98

-------
                                 SUBJECT IND> X
Persona) variables, effect on
   DDV, DDE, not dicldrin leveb   322
Ethnic differences, effect
   on Itfveb                      322

Socioeconomic differences,
   effect on leveb                 323

DDE re.idues in, humans           327
DDE, DDT levels in, cats           327
DDT, DDE in, humans             327

Organochlorines in, need for
   surveillance                    329

DDT, DDE in. children             336

Measurement of chants in
   protein metabolism             348

Dieldrin in, humans               349
Dieldrin in, humans, occupational
   exposure vs general
   population                    349

Lindane, blood dyscrasias           350

Occupational exposure, effects on
   white blood count              351
Effects on blood uric acid          351

Occupational exposure, DDT
   blood leveb                    3S6
                                            End/in, monkeys, effect on
                                                white blood cell count
                                 410
DDT, effects on blood pressure      359


                                 361
Baygon testing, red blood cell
   cholinesterase leveb
Chlorinated hydrocarbons,
   animal deaths, dilated blood
   vesseb                        370

Henutological effects of
   pesticides                     371

Pesticides in body tissues           385

DDT in newborni                 386

Blood dyscnsiu                  388

Studies needed, pesticide* in
   blood, general population       395

Allergic contact dermatitis         398
                                             Parathion. effect on blood
                                                cholinesterase, rats             411
                                             Organophosphate, effect on
                                                blood cholinestcf asc            411

                                             Organophosphates, blood
                                                cholinesterase                 414

                                             Parathion, blood cholinesterase,
                                                humans                       428

                                             Organochlorine* in, males vs
                                                females                       429

                                             DDE leveb in, humans, with
                                                administration of
                                                anticonvubint drugs            436

                                             Ofganophospluces, blood
                                                cholinesteraM, pilots            446

                                             Samples, indication of leveb        447

                                             Urine analysis, in comparison
                                                with blood                    448
                                             Mercury in                       448

                                             Chlorinated insecticides,
                                                analysis in                     449

                                             Use of agents for anticoagulant
                                                rodenticide poisoning, loss
                                                of blood                       451
Cholinesterase inhibitors,
   acetycholine in blood
                                                                              452
                                             Illnesses due to pesticides.
                                                need for blood examinations    455

                                             Human Monitoring Survey,
                                                analysis of                    496

                                             Aliesterasc in                     514

                                             Needed methodology for measuring
                                                enzyme induction, appearances of
                                                metabolites in blood            521

                                             DDE in, humans, Jicldrin
                                                administration                 528

                                             DDE in, humans, taking
                                                anticunvulsants                529
                                                                               99

-------
                                   SUBJECT INDEX
   Dicldrin in, studies on stress,
      starvation                     530

   Dieldrin levels in                   536

   Factors determining storage         537
   Dieldrin levels in                   537

   Dieldrin in humans, occupational
      exposure vs general population    538

   Monitoring mutation rates in
      blood cells                     601
   Pcntacfubrophenol, use in
      schistose minis ax
      mollusckide
   DDT in, humans, vs daily
      dose DDT

   Dieldrin in. animals, vs
      dieldrin in diet
   DDT to. rats, during
      post-exposure
                                652
   DDE. DDT in, human pregnant
      females vs spontaneous
      abortion                      675

BLURRED
   Blurred vision, airplane pilot        446
   Blurred vision, chofinesterase
      inhibitors                     446
   Chlorinated hydrocarbons,
      effects                       446

BODYFAT
   DDT in, monkeys, vs DDT in diet   277
                                278
                                280

DDT in, rats, vs DDT in diet        281

DDT in, monkeys, vs continuous
   exposure                      282

pj> -DDT in, humans, vs intake    283

HEOD in, rats, n concentration
   in blood                      285

DDT in, monkeys, after exposure
   terminated                    286
                                287
   p,p -DDT to, steers, after exposure
      terminated                    288

   P4> -DDA in urine,!. jmans vs
      p4>'-DDTinbodyfat           291
BOLLWORMS
   Cotton, pests                     84
   Pink boflworm                    84
   Spii.y boUworm                   84
   Use of chlorinated
      hydrocarbons to control         84

   Vegetables                        87
   DDT, control of bollworms         87

   Tobacco                          89
   Control of boDworms, use of POT   89

BONE
   o,p '-ODD, effect on bone marrow   301
   Methoxychlor. effect on bone
      narrow                       301

   Bone marrow, in vivo assays        589

BOWEL
   dass.ficd organophosphorous
      ag*nt. effect on bowel          412

BRADYCARD1A
   Organophosphonis compounds      371
   Effects oti cardiovascular
      system                        371

BRAIN
   Sevin (carharyl) residues in
      goats after spraying            139

   Diazinon poisoning, vascular
      pathology of                  367

   Pesticides in body tissues           385

   Behavioral effects                 407

   Studies on pesticide effects
      on indicators of brain
      function                      408

   Carbaryl, Baygon, effect on
      brain chofinesterase            410

   Parathion, effect on brain
      chclinesterase, rats             411

   Occupational poisoning, use of
      phenothiazines in, brain
      damage                       416

   Sleep deprivation, chlorpromazine.
      effects on                     418
                                           DDT in, rats, starvation
                                   431
100

-------
                                    SUBJECT INDEX
   Blood, urine, equilibration
      with brain levels
447
   Organcchlorine concentrations in    49S

   Residues of chlorinated
      hydrocarbons in                536

BRAINSTEM
   Chlorinated hydrocarbons          359
   Detection in bninstem             359

   Chlorinated hydrocarbon
      insecticides, DDT, effect
      on bninstem                   408

BREAL
   Bread, contaminated with endrin    158
BREAKDOWN
   Of insecticide uoge, world
      a ops
   Piperonyl butorJde, effect
      on breast
 83
   Spray insecticides, need to be
      amenable to breakdown in
      forest ecosystem                11!

   Of chlorinated hydrocarbons vs
      organophosphates. by bacteria    143

   Temperature, effect on
      biological breakdown           144

   Bacteria, participation in
      processes                      186

   Arsenic poisoning, tissue
      breakdown                    206

   Products, testing of in vivo
      •>ssays                         S89

   Fumigants, breakdown products
      of, exposure of general
      population                    612

BREAST
   Human breast milk, analysis
      for DDT                       374
   Breast-fed children, ingestion
      of DDT                       374
542
BREATH
   Dust of homes treated with
      Baygon, effects from
      breathing                     369
    Breath, shortness of, from
       inhibitor* of cholinestersse      446

 BRED
    breeding, for pest resistant
       oops                         60

    Breeding, us. d with other methods
       for disease resistance crops      161

    Breeding populations of birds       211
      Chlorinated hydrocarbons       211

    DDT, dieldrin in diet of birds
      bred in captivity, effects         212

    Cabbage yellows, control of         217

    Breeding for quantitative
      mutation                      S86

    Animal breeding, standardization
      needed                        660

BROADLEAF
    PI tnoxy herbicides, use for
      broadleaf weed control          68

    Aliphatic acid herbicides.
      toxicity to                     69

   Dinitroaniline herbicides, use
      for broadleaf weed control       70
   Nitrite herbicides, use for
      preemergence broadleaf weed
      control                        70

BRONCHIAL
   Pulmonary effects of
      organophosphorus compounds    361

   Effects of organophorus
      compoi ads on respiratory tract   369
   Bronchial asth'-'a from
      organophosphates               369

   Nasal and bronchial irritation
      caused by chlorinated phenols    3VO

BRONCHITIS
   Bronchitis, associated with
      greater pesticide exposure        352
   Parathioo, effects on general
      population and asthmatics       3S2


   Bronchitis, from exposure to
      inorganic arscnicals             363
                                                                                101

-------
                                   SUBJECT INDEX
r.RONCHOCONSTRICTION
   From topical application of TEPP    369

IttJGS
   Aldrin, use against corn
      bill bugs                       51

   Chlorinated hydrocarbon
      insecticides                    84
   Cotton pests; lace bugs,
      stink bugs                     84

   Rice bugs, endrin control of         85

   Tobacco pests, stink bugs           89
   Use of DDT to control             89

   Mealy bugs, parasites
      used against                    162

   Cinch bugs, insect pathogens
      to control                     163

   Bug bombs, use to control pests     263
   Inhalation of sprays in homes        263

   Endrin, control of plant bugs,
      lygus bugs                     648

EULBS
   Bulbs, regulation of imports         55

   Organic mercury compounds,
      bulb treatment                 66

   Ethylmercury rhlorir.', use to
      control basal rot of
      narcissus bulbs                 649

BULLAE
   Hexachlorobenzene, bullae
   '   formation from exposure to,
      humans                        364

   Bullae, from paraquat, diquat,
      humans                        365

BURN
   Inorganic herbicides, burning
      effect from                     67

   Organophosphorus compounds,
      burning of eyelids               367

   Ocular burns, paraquat/diquat
      exposure                       368

   Occupational toxicity.
      chemical bums                383
   Economic poisons, chemical
      bums                         442

   Chemical bums from
      organomercurials               443

BUTTER
   Dairy products, effect of
      enforcement oi Dt'aney clause   14

   DDT dissolved in butter,
      inf.estion by human, effect
      on lice                        298

   Effect of DDT and fat in diet,
      toxicity                       431

CABBAGE
   Vegetables                       87
   DDT, control of cabbage moth       87

   Caiboiyl reader* on cabbage        1^4
   Carburyl, half-life on cabbaje        134

   Polyhedral virus of cabbage
      looper                        217
   Virus control of pest insects         217
   Brecd-ig ot resistant cabbage        217
   Control of cabbage yellows         217

   Endrin, control of cabbage
      iooper                        648

CACTUS
   Biological control                  P2
   Control of prickly pear cactus
      by moth                       82


CANCER
   Dclarey clause                    14

   Possib'e effects of pesticides,
      increase incidence of             36

   Possible effects of pesticides,
      increase incidence of             235
   Need for perspective in,            261

   liver cancer in humans            262

   Pesticide levels and disease          328

   Organochloride pesticides in
      humans with                   391

   DDT, DDE storage in humar,   ith  430
102

-------
                                    SUBJECT INDEX
   Interaction among pesticides.                  Uses
      chemicals, suspected factors                Use rates
      in cancer causation              463
                                            69
                                            69
   "Spontaneous",  in humans, animals 464
   Objective in cancer prevention       464

   Animal testing, production of.
      consideration of for humans      467

   DDT, incidence of cancer in mice    471

   Tumorigenicity testing              477

   Results of toxic responses to
      chemicals

   Legislative needs

   Pathological evaluation

   Liver cancer

   Sesame oil, use in cancer
      research

   Dihydrosafrole, rats, cancer
      of the esophagus                 54 3

   Genetic alterations, possible
      effects                         S67

   Effects of DNA alterations,
      chromosome breaks             60S

   Ethylcarbamate, production of      607

CARBAMATES
   Pesticides, cholinesterase
      inhibitors                       34

   Pesticides after 1945                46

   Substitution for DDT               49

   Restriction  on persistcm
      pesticides, use of                51

   Baygon, use of, for diazinon
      resistant pests                   53

   Pest resistance, development of
      new compounds                 59
   Oarbamate insecticides
   Mode of action

   Synergistic action with
      other chemicals
64
64
65
           Persistence                        70
           Effects                           /O
           Toxicity to humans                70
           Toxicity to warm-blooded animals   70
           Examples of                      70

           Matacil, use in slug and snail
              control                        72

           Carbaryl, use in US.               104

           Zcctran, use for budwonn control    111
478

480

488

497

543

Potable water supply

Standards, limits

Daily intake
Residues in foods
Residues in food
Calculated daily intake

121

122

135
135
136
136
           Residues in foods, diet

           House and garden use,
             agricultural use, 1968
                                 138
                                 147
           Baygon, use to control resistant
              cockroaches                    151

           Accidents, by chemical, by
              industry, by occupation          154

           Mode of action in insects           206

           Cholinesterase inhibitors, toxic
              potential of.                    233

           Poisonings, humans                307

           Morbidity effects of
              occupational exposure           347

           Exposure, occupational             348

           Acute effects, on central
              nervous system                 359
Cholinesterase inhibitors,
   effects on eyes,
   mucous membranes             361

Gilorinatcd carbamates, MorcMan,
   effects, occupational exposure   364
                                                                                 103

-------
                                    SUBJECT INDEX
    Occupational^ related skin
       condition                     366

    Baygon, efiects                    367

    Baygon, effects                    369

    LD-50 of, with varying solvents      403

    Carbaryl, Baygon, effects
       in rats                         410

    Poisonings from                   442

    Economic poisons, effects on
       skin, general intoxication        443

    Cholinesterase inhibitors in use      446

    Cholinesterase inhibitors            4S2

    Use of oximes in treatment
       of poisonings                   453

    Tetraethylammonhim chloride,
       use to treat poisoning           454

    Ethyl carbamate, metabolism
       and carcinogenesjs              484

    QPC, tumorigerucity testing.
       rating                          490

    Ethylcarbamate, tumorigenicity
       testing, rating                  491
    Carbamates. tumorigerucity
       testing                         491

    Exposure to, studies on
       alfesterase activity              510

    Cholinesterase inhibition,
       interactions                    512

    Inhibition of aliesterases            513

    Levels in diet of nun from
       agricultural use                 514

    Toxicity, effect of enzyme
       inducing agents on              518

    Residues of, degradation of         525

    Synergists, effect on
       toxicity of                     541

    Synergists with                    542
    Isopropylphenyl carbamate,
      chromosome aberrations in
      higher plants                   583

    Mode of action, inhibition of
      oxidative phosphorylation        604

    May affect DNA                   607

    Carbaryl, usage, major
      insecticide                      610

CARCINOGENS
    Responses in testing for, dose
      related                        14

    Chemicals proposed for insect
      sterilization, effects              83

    Diethylnitrosamine, aflatoxin        261

    Weak carcinogen, discussion of       262

    Effects of on target tissues          464
    No safe levels in foods
      determinabie                  464

    Animals, selection of strains        465

    Production of tumors              466

   Interpretation of results            467

   DDT. carcinogen in mice,
      possibly humans               471

   Testing of chemicals, establishment
      of priorities                    473

   In animals, vs humans              482

   Pathological evaluation             488

   Biological alkylating agents          490

   Induction of microsomal enzyme
      activity                       517

   MDP compounds, animals           543

   3,4-Benzpyrenc                    544

CARCINOGENESIS
   Recommended, modification of
      Debney clause                  14

   Justification for modification
      of Delaney clause                15
104

-------
                                  SUBJECT INDEX
 Needed studies on, support for

 increasing incidence of

 Increasing incidence of

 Research needs, studies,
    procedures

 Areas of special study interests

 Cyclamates, concern of

 Determination of in animals,
    humans

 Potential of DDT, other
    insecticides, in mice

 In experimental animals, fish

 Of pesticides

 Panel on, responsibilities

 DDT. health benefits vs
    cartinogenicity hazard

 Evaluation of carcinogenic
    hazards
 Substances in food
 Reduction of exposure to
 Factors influencing
 Principles, criteria for
    evaluation of carcinogenic
    hazards

 Route of administration
 Number of animals
 Pathologic evaluation,
    classification

 Tumorigenicity, index of
    potential carcinogenicity

 Summary

 Pesticides tested, criteria
    for evaluation

 Category B, results

 DDT, carcinogenicity in animals

Category C, results

Triphenyltin hydroxide not
   tested for carcinogenicity
16

36

235

241
243
245


261

357
395

461

462

463


464
464
464
464

464

465
465
465

466
467

468

470
471

473
•

474
Recommen&tions for priority
testi.ig

Use practices, regulation with
respect to potential hazards,
recommendations
Recommendations
Methods, to determine
Oral intubation, conversion
into less carcinogenic
metabolite

Testing with neonates
Pathologic evaluation
Carcinogenic, mutagenic
interactions

No search for carcinogenic
effects of interaction at
target level
Piperonyl butoxide, not
carcinogenic for liver.
animals

Sesame oil, use in
carcinogenesis studies
Co-carcinogenicity
Co-carcinogenicity activity of
piperonyl butoxide. MDP
synergists

Freons and piperonyl butoxide
Synergistic toxkity,
carcinogenicity
Chromosome breakage, mutations
Mutagenicity, carcinogenicity
in animals, testing
CARCINOMA
DDT residues, association with
carcinoma
Aldrin, dieldrin. carcinoma
of the stomach
Organochlorine levels in
patients with carcinoma
Hazards of pesticide use.
carcinoma

476



478
479
481



-------
                                   SUBJECT INDEX
   Concentration of pesticides in
      patients with carcinoma         495

   Mammary carcinoma, Freon 112,
      piperonyl butoxide             545

CARDIAC
   Cardiac arrhythmias, symptoms in
      moderate to severe poisoning
      cases, organophosphates         360

   Cardiac damage in wine growers
      exposure to arsenical
      insecticides                    362

   Organophosphorus compounds,
      cardiac arrest                  371
   Compound 1080, cardiac arrest     371
   Paraquat, cardiac arrest             371
   Yellow phosphorus ingestion,
      cardiac enlargement             371

CARDIORESPIRATORY
   Dieldrin, cardiorespiratory
      functions recorded, humans     301

   Organophosphate poisoning,
      cardiorespiratory complaints in
      patients                       415

CARDIOVASCULAR
   Needed studies to  assess
      toxic effects of pesticides         16

   Cardiovascular diseases in
      persons exposed to
      organochlorine pesticides        349

   Chlorinated hydrocarbons,
      effects on cardiovascular
      system, animals, humans        370

   Organophosphorus compounds,
      effect on cardiovascular
      system                        371

   Cardiovascular diseases,
      comparison in persons exposed
      to pesticides                   430
                                         CARNIVOROUS
                                            DDD in carnivorous fish
                                    127
Cardiovascular system, physical
   exams
                                    444
   Employees of pest control
      companies, cardiovascular
      disturbances                  449
                                            Solar energy, use by carnivores      186

                                            Food chain, carnivores             188
                                            Population decline among
                                               carnivores
                                            Species commonly tested,
                                               teratogenicity studies
                                    211
                                         CARP
                                            Toxaphene, use to control carp     213

                                         CARROT
                                            Aldrin, uptake by plants, carrots    144

                                            Lmuron, for weed control in
                                               carrots                        650

                                         CASTRATION
                                            Liver enzyme activity,
                                               decreased by castration, rats     428

                                         CASTS
                                            Nitrogen compounds, esophageal
                                               casts, paraquat ingestion         373

                                         CATS
                                            DDT, bloo I DDE, cats in homes    148

                                            Anticoagulants, effects on cats      214
                                            Rodenticides, effects on cats        214

                                            DDT, DDE, cat* in homes          327

                                            Aldrin, effect on conditioned
                                               reflexes in cats                 409

                                            Arinphosmethyl metabolite,
                                               metabolism in cats             426

                                            Malathion, EPN effects in cats      523
                                   659
CATALYZE
   Effects of exposure of pesticides
      to air, sunlight                  115

   Ultraviolet light, catalyze
      oxidation of organophosphorus
      pesticides                      433
   Conversion of parathion to
      paraoxon                      433

   Alteration of liver microsoma!
      enzymes, which catalyze
      metabolism of chemicals         516
106

-------
                                    SUBJECT INDEX
CATARACT
    2,4-dinitrophenol, cataract
      production                    368

CATERPILLARS
    Botanical insecticides,
      effective against certain
      caterpillars                     62

    Control of alfalfa caterpillars       163

    Bacillus thuringieniis, control
      of caterpillars                 217

CATFISH
    Toxaphene, use to control catfish   213

CATTLE
    Methoxychlor usage, cattle,
      farm buildings                  51
    Methoxychlor, for fly control
      on cattle                       SI

    Rotenone, control of cattle grubs    63

    Cattle, acreage in Africa,
      grasshopper effects              91
    Annual losses of cattle products
      prior to dicldrin usage           91

    Water contaminated by 2,4-D,
      cattle area                     117

    Pesticide residues in cattle          138

    Excretion of pesticides in
      cow s milk                    139
    Toxaphene, fed to cattle,
      residues                       139
    Sevin, sprayed on cattle,
      residues                       139

    Spraying of cattle with
  i    insecticides                    140
    Residues in meat, milk             140

    Avkidrt, pest control without
      contaminating cattle feed       214

CAVITY
    Host-mediated assay, injection
      into intraperitoneal cavity       S94

CEREALS
   Cereal leaf beetle                  SS
   Quarantined pests                 SS

   Use of chemicals on                SB
   Cereal leaf beetle, pests             58
   Development of resistant crops      81
   Stem rusts                        81

   Crops, insecticide usage             84

   Chlorinated hydrocarbon
      L-jecticides for insect
      control                        85

   Organophosphate insecticides.
      found in                       136

   Bromide residues in                137

   2.4-?), weed control in              646

CEREPELLUM
   Chlorinated hydrocarbons,
      detection in                    359

   Chlorinated hydrocarbon
      insecticides, act in              408

CERE'jRAL
   Chlorinated hydrocarbons.
      detection in cerebrum           359

   Methylmercury, production of
      infamile cerebral palsy           675
   Fish consumption by pregnant
      women                        675

CHEESE
   Possible effect of enfoicement
      of Delaney clause               14
   Effect on dairy products           14

CHELATING
   Treatment of poisoning by
      heavy metal derivatives          452
   delating agents                   452

CHEMOSTERILANTS
   To:.icity to mammals              60

   Use for insect population
      control                        61

   Control of pests                   83

   Control of species                 164

   In combination with light traps      166

   For pest control                   219

   Compounds used for               519

   TEPA.METATEPA                598
                                                                                107

-------
                            SUBJECT INDEX
Prediction of mutagenicity
Not registered for use as
pesticides in U.S.

CHEST
Cholinesterinase inhibitors.
tightness in

CHICKENS
Concentrations of organochlorine
insecticides in eggs
Tri-orthocresyl phosphate.
neurotoxicity in

Studies in developing chick
embryos
Teratogenicity studies
Screening tests using chick
embryos
Teratogenicity testing

Captan, Folpet, teratogenic
in embryos
Organophosphates, teratofenic
in chick embryo
o.p'-DDT, reproductive
effect in

CH1CKWEED
Potassium cyanate, control of
CHILDREN
DDE blood levels in
Poisonings in

Poisonings in
Incorrect disposal of
containers, effects on
Storage of pesticides,
effects on

Rodenticides, effects in
Exposure to pesticides
Home poisonings in
Deaths in

Deaths in

Poisonings in
602

604



447



269

424


438
438

659
659


664

665

665


650

148
157

158

159
160

214
259
263
306

307

308
Pesticide poisonings in
DDT residues in

DDT, DDE in blood of

Carbamates, exposure of

Population groups involved
in poisonings

Arsenic poisoning in
Thallium sulfate ingestion by

Breast-fed, ingestion of
DDT-dcrived materials

DDT concentrations in
Diseases, survey by
questionnaire

Poisoning in

Parathion ingesuon by
Dental caries

Inheritance of mutant genes

Search for malformations

Thalidomide, effects in
Congenital malformations.
reporting of
CHLORACNE
2,4-D; 2,4,5-T; exposure of
workers
2,4-D; 2,43-T; exposure of
workers
CHLOROPHYLL
Chlorophyll-deficient mutations
Chlorophyll mutation frequency
Mutations in barley
Amitrol, inhibitor of
chlorophyll synthesis
Mode of action of pesticides
CHOLESTEROL
DDT, fat in diet, addition of

Trop'tal, piperonyl butoxide.
effect on level in bile
314
323

336

348


356

362
363


374

386

390

417

428
485

570

600

659

662


365

450
576
576
585

604
604

431


543
108

-------
                                     SUBJECT INDEX
CHOLIC
   Effect of pesticidal synergists
      on cholic acid excretion

CHOLINESTERASE
   Organophosphates, effect on
   Carbamates, effect on

   Carbamates, mode of action

   Organophosphates, effects on

   Organophosphates, effects on

   Pesticides, effects on

   Organophosphates, effects on
   Carbamates, effects on

   Research needs, significance
      of blood cholinesterase
      lowering

   Surveillance of by pesticide
      protection teams

   Surveillance of

   Lowering of levels

   Parathion, effect on

   Dieldrin, effect on

   Organophosphates, effect on

   Carbamates, effect on

   Dieldrin, effect on

   Testing, detection of toxicity

   Organophosphates, effect on

   Organophosphates. effect on

   Organophosphates, effect on

   Organophosphates, effect on

   Orsanophosphates, effect on

   TEPP, effect on

   Carbamates, effect on

   Parathion, effect on

   Echothiophate iodide, effect on

543

34
34
64
1S3
206
210
233
233


240


241

242

260

296
301
347

348

349
3S6
360
361

364
367
388

406

410
411

412
Pesticide effects on
Orgar.ophosphates, effect on
Paia.hion, effect on

Levels, airplane pilots
Deteirnination of levels of
Diagnosis of poisonings
EEC recordings
Inhibitors
Poisonings by pesticides.
treatment
Tolerances for inhibiting
chemicals

Potentiators of toxicity.
effects on

Organic phosphates, effect on

Mode of action of EPN, malatbion

Parathion, effect on, effect of
low protein diet
Organophosphates, effect on
CHROMATID
Characteristics used to classify
chromosome breaks
Characteristics used to classify
chromatic! breaks
Breaks
Breaks
CHROMATOGRAPHY
Gas-liquid, analysis of
pesticides
Pesticide analysis, gas liquid
DDT analysis, gas
Sources of error in analysis

Thin layer
Pesticide analysis
Thin layer
Determination of metabolites.
safrole, and other chemicals
414
425
428

446
449
450
451
452

453

512


513

514

524


532
665


590

590
592
593


170
173
257
75?

447
447
547

547
                                                                                 109

-------
                                    SUBJECT INDEX
CHROMOSOME
   Mutations                         570

   Bacterial methods for testing        572

   Neurospora                        573

   Phage. transformation              574

   Plants, use in mutagenic
      testing                         575

   Mutation induction by seed
      treatment                      576

   Root tip method, aberrations        577
   Somatic mutation methods         577

   Aberrations in higher plants,
      chemicals producing             583

   Aberrations in higher pUnts,
      chemicals producing             584

   Crosophila, screening of            586
   Break studies                      586

   Break studies                      587

   Mutations, aberrations              588

   Chinese hamster, uses               589

   Classification of breakage           590

   Chemicals producing breakage.
      mutagenic effects               591

   Characteristics in breakage           592

   Specific locus test                  595

   Dominant lethal test                596

   Monitoring of                      601

   Mice, testing                       602

   Breaks. DNA alterations             605

   Phenols, effects on                 607

   Captan, aberrations                 639
   Carbaryl, aberrations               639
   2,4-D; aberrations                  639

   Dkhlorvos, breakage               640
   Endothall. aberrations              640
   Ethytene oxide, breakage           640

   Ferbam, aberrations               641
   HCN, breakage                    641
   KOCN. breakage                  641
   Ltndane, aberrations               641

   Linuron, breakage                 642
   Maleic hydrazide, breakage         642

   Pandichlurobenzene, breakage      643
   2,4,5-T; aberrations                643

CHRONIC
   Organophosphates, toxicity          34

   Systemic herbicides, effect
      on plants                       67

   DOD poisoning, effects on birds     127

   Sinusitis, exposure to
      pesticides                      149

   Pesticides, effects on fish           210

   Toxicity, discussion of             259

   Pesticides, effect: on health         345

   Organophosphates, exposure,
      effects                        347

   Occupational surveillance           357

   Organochlorines, serum levels       358

   Organic mercurials, poisoning       362
   Arsenical poisoning                362

   Thallium  sulfate poisoning,
      hair loss                       365

   Organic mercurial derivatives,
      occupational exposure           368

   Household exposure to pesticides,
      bronchitis                     370

   Occupational exposure, workers     384

   Organophosphates, effect on
      cholinesterase                  388

   Pesticide exposure, diseases         394

   Skin penetration, toxicity           403

   Behavioral effects                 406
110

-------
                                    SUBJECT INDEX
    Carbaryl, tats, brain amines         410

    Oiganophosphates, exposure of
       pilots                         414

    Behavioral effects,
       Oiganophosphates              419

    Toxicity                          424

    DDT, fed to rats, effects            434

    DDT, exposure, humans            471

    Enzyme induction measurements
       needed                        510

    Enzyme induction measurements
       needed                        5 '.9

    P-peronyl butoxide. toxicity
       studies                        542

    Ffeons, toxicity, inhalation         545

    Mutagenicity testing               602

 CHUBS
    Er.drin in                         125

 CIGARETTES
    Precautions for pesticide
       operators                      445

CIRRHOSIS
   Of liver, DDT                     300

   Of liver, association with DDT
      residues                       329

   Of liver, recovery from
      acute poisoning, yellow
      phosphorus                    371

   Of liver, increased pesticide
      concentrations                 391

CITRUS
   Chlorinated hydrocarbon
      insecticides, use on fruit          84

   Insect pathogens                  163
   Studies on flies                   163
   Fruits, gamma irradiation           163

   Fruit, control of nematodes
      use of barriers                 199

   Crop, damage to                  216
   Monuron, weed seedling control in  651

CLAMS
   Endrin concentration in            125

   Chlorinated hydrocarbons in        129

   Monitoring of pesticides in          171

   Organochlorine insecticides in       208

CLAY
   Particle size, pesticide
      adsorption                    144

   Penetration of pesticides
      in soU                         199

   Movement of pesticides in sofl       204

CLOTHING
   Protective, precaution              77

   Cleaning of, dry cleaning
      exposure to DDT               150

   Protective, for workers             153

   Exposure to pesticides             155
   Orchard spraymen, protective       155
   Protective, exposure to
      pesticides                     156

   Purchase of, by consumers          221
   Pesticides, effect on cost
      of fiber                        221

   Protective                         250

   Controlled human exposure,
      effect of protective             295

   DDT-impregnated, effect of         297

   Protective                         308

   Protective                         356

   DDT, applied to, effects            363

   Protective                         444

CNS
   Research needs                    241
   Detection of CNS effects of
      pesticides in man               241
                                                                                111

-------
SUBJECT INDEX
OOCARQNOGEN
Sesame oil
Safrofe, rat hepatogen
Piperonyl butoxidc
MDP synergists

COCKROACHES
Pest control
Humans, exposure to chemicals
Commercial pest control
industry

Pest control, use of DDT for
Inorganic insecticides
Lead arseiiate, use to control
Baygon, use to control

Diazinon, for resistant
Chlordane, for
DDT dust for
German cockroach, treatment for

Disease vectors
Control of
Metabolism of phosphorothionates
COCONUT
DDT, effect of fat in diet
COFFEE
Total insecticide usage

COHO
DDT in salmon fat
Salmon, effect of wastes on
Concentration of residues in
salmon
Effects of pesticides on salmon
COLLAPSE
Organophosphate insecticides,
effect on thermo-regulation
in animals
rnirtN

543
543
544
544


53
53

53

54
62
62
65

151
151
151
151

164
263
555

431

84

13
119

220
357


533

Stain of pollen grains

Specific locus test
Endrin, light colored

CQRLESS
Acrylonitrile, liquid
Atratone, crystalline solid
Captan, to buff powder

Carbaryl. crystalline solid
Chloroform, liquid
2.4-D; powder
DDT, or cream colored
Dichlorvos, to amber
Ethylmcrcury chloride,
crystalline solid
Formaldehyde, gas

Potassium cyanate, crystalline
needles
Lindane, odorless crystals
Linuron, crystalline solid
Monuron. crystalline solid
Maleic hydrazide
Faradichloiobenzene, crystals
t hosphamidon, oil
Propham, crystals
Simazine, crystalline solid

COMA
Signs and symptoms of
pesticide intoxication
Effects on the nervous system
Miscellaneous pesticides, effects
Behavioral effects of solvents
Effects of kerosene or xylene
in air

CONGENITAL
Reporting of abnormalities
Malformations, effects of
Malformations, definition
578

595
648


645
645
645

646
646
646
647
647

649
649


650
650
650
651
651
651
653
653
653



360
362
371
417
417

600
657
657
   Cancer of. possibly related
      to pesticides                   498

COLOR
   Plants heterozygous for
      flower color                   577
Human exposure, abnormalities     659
Need for standardizing
   procedures in handling and
   categorizing malformations
660
112

-------
                                   SUBJECT INDEX
   Population monitoring             661
   Induction of malformations
      in animals by pesticides          661

   Recording and reporting of
      malformations                 662
   Surveillance program               662
   Use of information on
      birth certificates                662
   the of data from foreign
      countries
663
CONJUNCTIVITIS
   Effects of pesticides on the eye      366

   Caused by chloro-2-phenylphenol    368
   Caused by sodium orthophcnyl
      phenate                       368
   Caused by Gentian Violet dust       363
   Caused by sulfur, sulfur
      compounds                    368
   Caused by lime-sulfur mixtures      368

CONTAINERS
   Needed instructions for
   PCB analysis, sources of
      erroi, storaf in plastic          258

   Parathtan, poisonings              306

   Safety, children                  308

   Poisonings, improper
      disposal of                    356

   Dowcide-7, use on                475

CONTAMINANT
   Phenoxy acid herbicides,
      irrigation water                124

   Organop:tosphates, manufacture of  153
   in air, exposure of workers         153

   Steps for removal of from water     192

   Graded actions                   240

   Study of environmental
      contaminants                  463
disposal of
Needed regulations for
disposal of
Needed safe methods of
disposal of
Purpose of labels on
Needed methods of collection
and disposal of
Needed safe methods of
disposal of
Design of, needed to prevent
accidents
Disposal of used
Corrosion of. environmental
pollution
Disposal of
Disposal of

Accidents, improper storage
of pesticides in
Needed standards, labeling of
Disposal of
18
18

24
76

78

103
157
159
193
194
201

234
242
242
rood additives and contaminants
Use permitted if non-o>rcino«enic
In foodstuffs
Persistent pesticides
Levels of exposure to MDP
compounds
In foodstuffs
CONVULSION
Endrin, effect on dogs
DDT. effect on birds
Diene group, studies in
patients
Chlorinated hydrocarbons
Signs and symptoms of poisoning
Chlorinated hydrocarbons,
effect on animals

Miscellaneous pesticides, effects
Effects in children, poisonings
DDT poisoning, animals
Therapy, to control
467
467
472
472

560
611

158
211
349
359
360
370

371
417
425
425
                                                                               113

-------
                                   SUBJECT INDEX
   Poisoning by dinitrophenol and
      pentachlorophenol             450
   Use of diphenylhydantoin to
      control
   Fats in diet, effect on DDT
      toxicity
451
COOKED
   Heptachlor epoxide residue in
      raw and cooked meat ftom
      cattle                         138

   Use of lime-sulfur mixtures,
      cooked or uncooked, on fruits    368

CORN
   Use of peiucides on                47

   Aldrin, use on                     51

   DieldriR, use to control pests        52

   Use of organophosphates on         104

   Acrolein. use on                   124

   Dieldrin, use on                   133

   Resistant strains                   162

   Avicides, use around               214

   Crop rotation                     218
  1
   2,4-D; use for weed control on      646

   Dicamba, use in                  647

   Endrin, use to control pests

   Linuron, use for weed control in    650

   Parathion. use to control
      bisects

CORNBORER
   Resistant plants
   Imported predators and
      parasites to control

CORNEAL
   Paraquat, effects on epithelium     368
   Nitrogen compounds, effects on    368
   Effects of propellants on

CORNEUM
   Enzymes in stratum corneum
CORROSION
   Packing materials               159

   Failure of container, from          193

   Industrial cooperation             242
   Design of containers to prevent      242
        CORTEX
           o,p '-DDD, effect on adrenal
              enzymes
                                   300


                                   418
           Seconal. effect on corturj
              activating system
           Chlorpromazine. effect on cortical
              activating system              418
           DDT, effect on adrenal            435

           EEC recordings in pesticide
              poisonings                    451

           Induction of enzymes in adrenal     50

           Need for study of induction of
                                           520
COSMETIC
   Food, Drug and Cosmetic Act        14

   Effects on skin                   363

   Delaney clause of Food
      Additives Amendment          480

   Food, Drug and Cosmetic Act       486

   Exposure to, interactions          5?S

648
650

652

162
162

368
368
368

401
COITON
DDT, use on
DDT, use on
Endrin. use on

Insecticide usage on
Carbaryl, use on
Acrolein
Resistant varieties

2,4-D; tested on

Carbaryl, use on
DDT, use on

43
47
52

84
104
124
162

639

646
647
114

-------
   Endrin, use to control pests

   Ethyl'.ne oxide, use on

   Linuron, -X on

   Paralhion, use on

COTTONSEED
   In animal feed

   Monuion. control of weed
      seed lings in

COUGHING
   Baygon treatment of houses,
      effects

   Cholinejtcrase inhibitors, signs
      and symptoms of poisoning

COWS
   Grasshopper control, cows,
      acreage

   Heptachlor, residues in

   DDT, fed to

   Spraying of, with toxaphenc
   Chlorinated hydrocarbons in milk

   Bromide in peanut hay, fed to

   Dieldnn, concentration in

   DDT, concentrations in

   Concentrations of organochlorines
      in milk

   DDT in cow's milk, human milk

   Pesticide in milk

   Treatment with activated
      charcoal and phenobarbital,
      dieldrin residues

   Dieldnn, incidence of
      stillbirths in
   DDT. incidence of stillbirths in

COYOTE
   Chemical control measures for

CRABS
   Concentrations of DDT. DDD.
      DDE in
SUBJECT INDEX
648

649

650

652

138

651


369

447


91
138

139

140
140

198

265

268

269

385

484


528

665
665

71

129
Marine invertebrates
Susceptibility i.> chemicals

Exposure of. to DDT
Dieldrin, effect on mortality
Effect of ' atinj: DDT containing
organisms
Developmental pheronx-nes
Dangers to non target organisms
CRABGRASS
Metal organic compounds, use to
control
Potassium ryanate. use to
control
CRANBERRY
Movement of parathion in bogs
CREAM
Ice cream, effect of Delaney
amendment on residues in
Difobtan, dennadtis, use of
barrier creams in

DDT, colorless or cream soli J

CRICKETS
Aldrin, for con'rol of

BHC. for control of

CRUSTACEA
Exposure to pesticides.
effects on
CUCUMBER
Grown on soil treated with
aldrin. dwldrin and
heptachlor
Residues of pesticides in
CUCURBITS •
Lindane. use for

Naptalam, use for
CUMULATION
Thallium sulfzte, properties
10 year death rate bom
pesticides
DDT, in environment
DDT, metabolites, data
208
208

209
209

109
219
219


68

650

124


14

365

647


52

86



209



132
132

650

651

73

158
245
321
                                                                               115

-------
                                    SUBJECT INDEX
    Compounds, stored in fat

    Effects of anticholinestense
       insecticides on enzyme
       activity in wildlife

    Organophosphates, effects on
       esterase activity in wildlife

    Mammalian toxicity of MDP
       compounds

CUTWORMS
    Aldrin, used to control

    Chlorinated hydrocarbon
       insecticides, used to
       control cotton pests
    Cyclodienes. used to control

    Rice, use of DDT to control
    Toxaphenc, used to control
    Cereals, BHC .o control
    Cyclodienes, used to control

    Vegetables, DDT to control

    Tobacco, use of DDT to conf )I

    Endrin, use to control

CYSTIC
    2,4,5-T, cystic kidneys

    Carb»ryl plus piperonyl butoxide,
      I Auction of cystic kidneys

CYTOGENETICS
    Mammalian methods, testing

    Chromosome b. eats, indicator
      for «wne mutation

    Studies

   Testing

    Dominant lethal test

    Mammalian tests

   Recommended protocol, testing
      of compounds

CYTOLOGICAL
   Pyrethrum, effects on uc liver
   DDT, pyrethrum, piperonyl
      butoxid:. effect on rat liver
425
Freons, pipcionyl butoxide.


510

514

542

51



84
84

85
85
85
85

87

89
6*8

665

666

587

588
589
590

596
601

603

544
544
effect on liver
Methods

Studies, flower buds
Dominant lethal test
In rats, dominant lethal assay

Monitoring human population
DEAD
ODD, toxicity to fish.
aquatic organism*
Analysis of Western grebes
for HDD

DDT, effect on worms

Human skin, effect of enzymes
on chemicals

Examinition for fetuses

Pesticides, effect on fctus
mortality and fetus resorption
DEATH
Pesticide, use
Anticoagulant rodcntkides.
mode of
Parathion, humans
Pesticide usage

Occupational, agricultural
Radiant energy, effects
Birds, seed treatment effects
DDT. eiTects on nervous system.
insects

Pesticides, effects in fish
DDT, poisonLig in birds

Acute toxicity, discussion of
Mortality, pesticide poisorin;^
Mortalities
545
577

578
596
597

601


176

126

208


401

667


668

44

72
81
157

158
167
200

206

210
211

259
305
306
 116

-------
                                 SUBJECT INDEX
 Occupational poisonings            307

 White phosphorous paste            309

 Epidemics of poisoning by
    pesticides                      310

 Epidemics of poisoning by
    pesticides                      311

 Mortality studies                  345

 DDT, effects from solutions of      359

Organophosphates, effects          360

Organophosphates, effects          361

Organic mercurial compounds,
   effects                        362
Inorganic arsenicals, effects         362

Organophosphoms compounds      369

Paraqua:, mgcstion of              370

Yellow phosphorus, ingestion of     371

Rates, general population,
   pesticides, aplastic anemia       372

Pesticides, skin contact             404

From pesticides                   424

DDT, effects                      425

Parathion. effects                 428

DDT, DDE storage  in               430

Matacil, effects                    454

Rates, liver cancer                 497

National Death Index              498

Mutations, effects on cell           569

Chromosome aberrations, effects    588

Dominant lethal mutations,
   effects                        597

Adverse genetic effects             598

Teratogenicity testing              659

Statistical analysis                 667
 DECOMPOSITION
   Fungicides, properties of            65

   Disposal of wastes, risks of          128

   Dithiocarbamates, during
      harvesting and processing of     136

   Steps in processing,
      manufacturing of pesticides      192

   Of pesticides by soil biota           202

   2,4-D; effect of soQ
      microorganisms on              203

   Of herbicides in soil                204

   Of chlorinated hydrocarbons        366

   Lindanc, thermal effects on         369

DECONTAMINATION
   Of skin, in Parathion
      exposure                      400

DESK
   Effect of dicldrin on
      reproduction                   213

   Mammalian repellents              215

DEFECTIVE
   Packaging of pesticides             159

   Packaging and transportation
      of pesticides                   193

   Cholincstcrase inhibitors,
      effect on eye                   367

   Effects of phosdrin and/or
      parathion poisoning in humans    417

   Thalidomide, effects on
      children                       659

DEFOLIANTS
   Usage, number of chemicals         67

   Usage patterns                    147

DEGENERATION
   Juvenile hormones                 165

   Experimental  oral exposure
      to DDD                       300
   Effect on adrenals in dogs           300
                                                                             117

-------
                                    SUBJECT INDEX
   Neurologic degenerative
      conditions                     394

   Safrote, effect on liver in rats       543

DEGRADE
   Needed research on degradation
      of pesticides                    16

   Needed studies on degradation
      of pesticides                    23

   Needed studies on degradation
      of pesticides                   101

   Survival of degradation by
      photochemical reactions         113

   Ail, sunlight, reactive
      compounds, effect on
      degradation of pesticides        1 IS

   Persistent chlorinated
      hydrocarbons, metabolism by
      plants                         133
   Time factor, effect on

   On foods

   Soil contamination
134

141

143
   Moisture, effect on degradation      144

   Packaging materials, need for
      resistance to degradation        1S9

   Need for evaluation of
      degradation of pesticides        169

   Factors considered in policy
      decisions                      174

   Cumulation in food chain           192

   Release of pesticide from
      granules, fate of                200

   Of 2,4-D, related compounds
      by soil microorganisms          203

   Toxicological complexities          246

   Persistence                        248

   Factors affecting compounds        249

   Organophosphorus compounds,
      effects on genito-urinary
      system                        373
   DDE. degradation product of DDT,
      exposure estimates, humans     384

   DDE, degradation product of DDT  386

   DDA, degradation product of DDT  388

   Degradablc pesticides, hazards,
      carcinogenicity vs persistent
      pesticides                     478

   Ordimethoate                    513

   EPN, malathion administration      523

   Piperonyl butoxide metabolites     548

   Piperony! butoxide, exposure
      to environmental conditions     560

DELETERIOUS
   Education and training to
      reduce deleterious effects
      of pesticides                   11

   Withdrawal of organochlorines       49
   Effect on world food production    49

   Organochlorincs, effects on
      molluscs                       208

   DDE, effect on mallard ducks,
      reproduction                   209
   DDT, effects on mallard ducks,
      reproduction                   209
           Mutations in fruit flies
                                    571
        DEMYEUNATION
           Organophosphorus poisoning,
              paralysis with demyelination     416

        DEPRESSANT
           Treatment of poisoning             451
           Use of phcnobarbital and
              pentobarbital                  451

        DEPRESSED
           Cholincjterases, poisoning by
              pesticides                      450

        DEPRESSION
           Of cholincstcrase levels,
              pesticide poisoning             153

           o,p '-DDD, effects in humans        301

           Of cholinesterase levels,
              pesticide exposure              389
118

-------
                                   SUBJECT INDEX
   Aldrin, effects in monkeys          410

   Organophosphorus poisoning,
      effects                        413

   Organophosphorus insecticides,
      FAX workers                  414

   DMSO, effects on spontaneous
      motor activity, rats             417

   Psychosis, organophosphonis
      •gents                        420

   Baibituntes. use in DDT
      poisoning         •             42S

   Chlorinated hydrocarbons, effects    447

   Organophosphate poisoning,
      effects on respiration            S34

DERMAL
   Needed schem: for denoting
      dermal toxicity                 17

   Carbanuies, irritation              70
   CDAA, toxic                      70

   Needed scheme for denoting
      dermal toxicity                 77

   Parathion, potential dermal
      exposure, humans              112

   DDT, DDD, DDE residues in
      cows milk                     140

   Pesticides, exposure                155

   Exposure, work  situations          156
   Parathion exposure                 156

   Parathion exposure                 296

   DDT exposure                     297

   Exposure of humans               307
   Parathion exposure                 307

   Parathion, methyl parathion
      exposure                      308

   Acute dermal toxicity. LD-50       312
   Phosphate ester pesticides          312

   Acute dermal toxicity, LD-50       313
   Chlorin.itcd hydrocarbon
      pesticides                      313
   Orgarophosphates, toxicity,
      route of exposure              347

   Diene group, studies               349

   Paratliion, paraoxon studies        '02

   Acute dermal LD-50 values.
      correlation with occupational
      poisoning                     423

   Dteldrin, LD-50, rats               430

   Parathion exposure, humans        433

   DDT exposure, humans            445

   2.4-D;2,4,S-T. effects on skin      450

DERMATITIS
   Persistent pesticides,
      production of                 135

   Chlorinated hydrocarbons          363

   Effect on absorption of organic
      phosphorus compounds     .    364
   TEPV, production of               364
   Parathion                        364
   Naled, production of              364
   Dithiocarbamates, production of    364
   Chlorinated earbamates,
      production of                 364
   Pentachlorophenol. production of   364

   Phenolic derivatives,
      production of                 365
   Nitrogen compounds,
      production of                 365
   Captan, production of             365
   Difolatan, production of           365
   Sulfur, production of              365
   Metallic derivatives,
      production of                 365
   Chloro-2-phcnyIphenol,
      production of                 368
   Sodium onhophcnyl phenatc,
      production of                 368

   Allergic contact                   398
   From pesticides                   398

   Rodannitrobenzcnc, production of  399
   Captan, production of             399
   Phaltan, production of             399
   4-chloro-2-methyl-
      phenoxyacetic acid,
      production of                 399
   Difolatan, production of           399
                                                                               119

-------
                                    SUBJECT INDEX
   Chlorinated hydrocarbons,
      effects                        447

   Pesticides, occupational
      exposure                      449

DESSICANT
   Usage pattern, defoliants and
      dessicants                     147

DETECTION
   Constituents in foodstuffs           14

   Of pesticides in air                114

   Of DDT in water                  120
   Of endrin in water                120

   Of 2,4-D in water                  124

   Of 2,4-D in water                  126

   Of residues, chlorinated
      hydrocarbons                  128

   Of arsenic residues in food
      samples                       137

   Of residues in cow's milk           139

   Of residues of toxaphene,
      strobane                       140

   Of parathion in water from soil      144

   Of dieldrin in runoff water         145

   Use of light traps                  166

   Of pesticides in sur/acc waters      171

   Of treated seed, contamination of   200

   Compounds interfering with
      detection of p,p-DDT,
      p,p'-TDE                     257

   Of DDT in air, water               326

   Of pesticides in autopsy tissues      386

   EEC recordings, use                451

   Tissue storage of pesticides         536

DETERGENT
   Effect on persistence of
      organophosphates               82
        for further work on
      effect of detergents on
      pesticides                      511
   interaction of pesticides
      and detergents                 526

   Heed for further work on
      pesticides and detergent
      combinations                  530
   Pesticide-detergent
      combinations                  530

DETOXIFICATION
   Carbamates, rate of                64

   Fungicides, bactericides            65

   Of2.44-T                        204

   Evaluation of results,
      epidemiological studies          329

   Organophosphates, metabolite
      p-nitrophenol                  348

   EOTA, use in heavy metal
      poisoning                      452

   Koutr of administration, possible
      effect on substance              487

   Organic phosphate insecticides,
      effect on esterases               511

   Aiiesterases, effect on
      malathion                      513

   Role of aliesterases in, humans       514

   Organophosphates, effect on
      enzymes        ,               515

   Enzyme induction, effect on        517

   Effect of 3-methylcholanthrene
      on Guthion toxicity             518

   Storage of pesticides, effect
      of chemicals on                 525

   MDP synergists, effects             526

   Dietary effects on pesticides        532

   Pesticide interactions with
      synergists                      540

   Of 3,4-benzpyreiv                 544
120

-------
                                    SUBJECT INDEX
   Mode of action of MDP compounds  554

   MDP compounds, effects           555

   MDP compounds, effects           559

   Host-mediated assty               594

DIARRHEA
   Chlorinated hydrocarbons,
      effects of                      359

   Castro-intestinal effects
      of pesticides

   Inorganic arsenicals, effects

   Poisoning by pesticides, signs
      and symptoms

DIED
   Contact herbicides, effects
      on plants

   Analysis of birds for DDD

   DDT, DDE concentration* in
      persons dying from other
      diseases

   Morbidity and mortality survey      390

   Phosdrin and/or parathion
      exposure, human

   DDT, DDE in persons dying from
      cancer, other diseases

   POots, exposure to pesticides        445

   Ni'ional death index

DISPOSAL
   Obsolete products, disposal of       77

   Disposal of pesticide containers      159
   Disposal of animals exposed
      to pesticides                   159

   Disposal of pesticide containers      194

   Disposal of pesticides, wastes        201

   Metabolism of foreign compounds
      by animals

DIZZINESS
   DDT. effects
426


298
            Chlorinated hydrocarbons,
               effects of                     359
            Acute DDT poisoning             359

            Oiganophosphate exposure, chronic 414
            Metaisosystox poisoning           414

            Behavioral effects of solvents       417

            Symptoms of poisoning with
               economic poisonings
         DOG
                                    449
361
362
450
67
126

328
390
417
430
445
498

77
159
Pests, Brown dog tick
End in, convulsion? in
Ralenticides, poisoning in
DieMrin, concentrations of
HEOD in
Dieidrin, HEOD in
DDT.HEODin
Organochlorines in
HEOD in. vs daily intake
DDF, effects in
Testing procedures,
carcinagenicity
Aramite, tumorigenicity
testing in
Dieidrin, effect on metabolism
of 6-chloro- 1 7-acetoxy
progesterone in
EPN, malathion, effects in
AMiin, DDT. storage in
DDT, residues in
151
158
214
265
266
267
269
279
300
465
470
520
523
528
539
   Piperonyl butoxide, toxitity in      542

   Piperonyl butoxide, excretion in    547
   Teratogenitity testing in           659

   Carbaryt, teratogenic studies in      664
   Organochlorines,
      embryotoxicity in             664
DRIFT
   Aerial spraying, conditions
23
                                                                               121

-------
                                    SUBJECT INDEX
   Application methods, to reduce      60

   Aerial spraying, conditions          102

   Pesticides in air                    10S

   Microdimatology effect             107

   Weather conditions for
      appticttion of pesticides         108
   Pesticide formulation, particle
      size                            108

   After DDT application              109
   Climatic conditions, particle
      size                            109

   Particle size, effect on              110

   Pers&snce of pesticides in air       115

   Applications by airplane            132

   Parathion. node of application       155

   Of herbicides in air                 195

   Forest treatment                   196

   Granules, pellets, control of         199

   Small particles                     201

   Non-target effects from
      herbicides                      203

   Phytoplankton                    207

   Precautions, pesticide
      operators                       445

DRINK
   Standards, drinking water           24

   Repellants, used to protect
      food and drink containers        75

   Standards, drinking water           103

   2,4-D contamination of water       117
   Cattle, contaminated wa ter          117

   Standards, drinking water           121

   Guidelines, drinking u ater          122

   Water quality for food products      123

   Spraying, precautions               126
   Contamination of water supply,
      devices                         146

   Containers, disposal of, uss of        159

   Carcinogens in water,
      information needed              262

   Precautions, pesticide operation      444

DROSOPHILA
   Mutagcnicity testing                585

DUCK
   DDT, effects on egg shells in
      ducks                          25

   Specks for  monitoring
      pesticides in wildlife             171

   DDT, effects on egg shells
      in ducks                       179

   DDE, effects on reproduction
      in ducks                       209

   DDE, effects on reproduction
      in ducks                       212

DUSTS
   Pyrethrin, allethrin.
      formulation as                  62

   Aircraft, use to apply               105

   Spraying equipment, aircraft         106

   Pesticide formulations,
      particle size                     108

   Drift of DDT formulations           109

   Particle size                       110

   Major pesticide formulations         112

   Storm, transport of pesticides        113

   Pesticides in air                    115

   Large scale  of operations            132

   Pesticide levels, correlation
      with dust levels                 148

   Insecticides, household use, DDT     151
   Sodium fluoride, pyrcthrum,
      use for dusting                  151

   Occupational exposure to           152
122

-------
                                   SUBJECT INDEX
   Exposure to endrin, humans        1S5

   TEPP, exposure to                1S6

   Development of resistant crops     161

   Control of Japanese beetle         163

   Protection of employees against     192

   Incorporation during planting       199

   Transport by air                  201

   Surveillance of dusters             242

   Inhalation of                     263

   Controlled human exposures        29S

   DDT. inhalation of                298

   Dust vs pesticide levels             327

   Gent-an violet, effects             364

   Inhalation of, homes treated
      with Baygon                  369
   Dhhiocarbamate exposure,
      effects                        369

   2-chlorophenyIphenate. sodium
      orthophenylphenate. effects     370

   Personal protective equipment      444
   Organophosphates, protection
      from                         444

   Application form(D)               645

DYSCRASIAS
   Chlorinated hydrocarbons          350
   Undane, blood dyscrasias          350

   Blood dyscnsis. pesticides         388

DYSFUNCTION
   Occupational exposure to
      pesticides                     351
   Neurologic dysfunctions           351

   Chlorinated hydrocarbons         372
   Gastrointestinal tract              372
   DDT. effect on liver               372

   DDT-induced histological changes   434
   Hepatic dysfunction               434
   EEC recordings, cortical
      dysfunction                   451
   Chlorinated hydrocarbon
      poisoning                     451

DYSPNEA
   Organopho5<>hates. moderate to
      severe poisoning               360
   Signs and sy mptoms               360

DYSTONIA
   Autonomic Jystonia               409
   Behavioral cnanges in workers
      exposed to DDT and related
      chemicals                     409

DYSTROPH1C
   Dystrophic hair follicles,
      human, use of Fekema ES-30-9   405
   Sample skin matrix                405
   Nail dystrophy                   405
   Hair dystrophy                   405

EAGLE
   Monitoring of pesticides in         171

   Eagles, failure to reproduce         210

   Carnivores, decline in
      population                    211

   Bald eagle, reduction in numbers    437

EARTHWORMS
   Robin mortality, feeding upon
      earthworms                   210

ECG
   Dieldrin, effects on                349

ECOLOGY
   Research needed on persistent
      chemicals, effect on             9

   Eradication of pests                28

   Concern of pesticide residues on     80

   Less persistent pesticides,
      effect on                      161

   Insect control, parasites and
      predators                     162

   Cultural  or environmental
      control                       164

   Integrated control techniques       167
                                                                              123

-------
   Eradication of pests

   Food web

  . Herbicides, persistence in
      soil

   Chlorinated hydrocarbons

   Surveillance system, information

   Registration and review of
      pesticides

   Pesticide protection teams

   Manufacturer, concern for

   Epidemiology of pesticides
   Signals from fish, birds

   Effect of pesticides on birds,
      fish

   Chlorinated hydrocarbons,
      potential hazards, u»e of
      other chemicals

ECOSYSTEM
   Needed increase support for
      research of pesticides on

   Application of pesticides,
      knowledge of

   Insecticides, breakdown in
      forest

   Integrated control techniques

   Application of pesticides,
      knowledge of

  ' Chemicals in, movement in

   Changes in, costs and value
      to society

EDEMA
   Organophosphorus compounds
   Effects on eyes

   Nitrophenols, effects

   Urganophosphorus compounds
   Systemic poisoning, effects

   Dieldrin, effect oc cells
      and liver
SUBJECT INDEX
«
182

188

205

212
237


238

241

245
305
305

357

610


16


29


111

167


183

187

220

361
361

370

369
369
EEC
Dieldrin, effects on

Dkldrin. effects on
Organophosphorus compounds.
effects

Diagnosis of poisonings
EGGS
Delaney clause, effect on

DDT, effect on egg shells, birds

Inject control, residue at
various stages of life
OQs, effect on mites, aphids
Sterility, effect on
Radiation, effect on fruit fly
DDT, effect on egg shells, birds
DDE, effect on egg production.
shell thickness
DDT in fish

Bird population decline, egg
breakage

DDE, effeu on egg shell
thickiv.-ss

Exaction of organochlorines in

Mutation, chromosome changes
transmission of

DDT, dieldrin, effects on
shell thickness
EGGPLANT
Carbaryl residues on
Residues, half-life in
EGGSHELL
Weight of, effects of
pesticides on

Thickness in birds fed
chlorinated hydrocarbon
pesticides

301

349

443

451

14

25


S3
62
164
167
179

189
209


211


212

269


569


665

134
134


211



437
432
DDT, dieldrin, effects on
   eggshell
                                             665
124

-------
                                  SUBJECT INDEX
   Reproductive effects               665

EGRET
   Toxaphene. mortality in fish
      eating birds                    211

ELMS
   Dutch elm disease, use of
      mcthoxychlor in               SI

   • •   h elm disease control          211
   7 .cct of pesticides on
      robin population               211

   Dutch elm disease, control of       218

EMBRYO
   Need for knowledge, effect
      of chemicals on embryos        455

   Embryo homopcnates, tests         589

   Captan. human embryo, effects on   639
   HCN, mammalian embryo.
      effects on
640
   Chick embryo, screening method    659

   Testing of non-human primates     661

   Captari, folpet, teratogenk in
      chick embryo                 664

EMBRYOLOGICALLY
   Organochlorines, effect on
      development of molluscs       208

   Death, embryonic stage            569

   Dominant lethal test              596

EMBRYOTOXIOTY
   Use of lower mammalian species,
      donge. effects                659
   Organochlorines, dieldrin.
      chtordane, kepone toricity in
      rats, dogs                    664

   Organophosphates, effects         665

EMOTIONAL
   AUrin, effects in monkeys         410

   Organopbosphate exposure.
      humans                      414

   Behavioral changes, pesticides      418
        ENCEPHALITIS
           Encephalitis, control of

        ENCEPHALOPATHY
           Thattoto.xicosu, effects
           DDT, induction of, humans
                                             Species differences to
                                                chemicals

                                             Activity of, sewage
                                                differences'
                                196


                                363
        ENZYMES
           Organophosphates, inhibition of
              cholinesterase                  34
           Carbamates, inhibition of
              cholinesterase                  34
                                36
Organophosphates, inhibitor of      64
Carbamates, ini libition of           64

Organophosphates, effects "-.        81

Effect of plant characteristics
   on residue                    134

OrganophosphatRS, parathion,
   effect on                      206

Organophosphates, inhibition of     233

DDT, induction of. humans         235

DDT, induction of, humans         246

DDT, effect in selected jaundiced
   patients                      300

DDT, induction of, humans         329

Induction                        347

DDT, induction of, humans         356

DDT, induction of, humans         357

Organophosphates, inhibition
   of, humans                   360

Organophosphates, effects on       361

Induction                       388

In stratum comeum, hydrolysis
   of chemicals                  401

Organophnsphates, effect on       425
                                          426


                                          428
                                                                            125

-------
                                    SUBJECT INDEX
   DOT, methoxychtor               430

   Liver. DDT effects                432

   Induction                        434

   •;.-faction of. liver microsomal      43S

   Liver microsomal, infrastructure
      changes                       436

   DDT, chlorinated hydrocarbons,
      effect on, reproduction         437

   Liver, activity, newborn vs
      adult mice                     484

   Microsomal activity, induction
      01, need for study              510

   Induction of                     SI I

   Aliesterases, activity               513

   Malathion toxicity                514

   Activity, pesticide interactions
      through alteration of           516

   Induction                        517

   Organophosphates, effect on        518
   Induction                        518

   Induction                        519

   Induction, need for information,
      studies in progress              520

   Induction, research needed         521

   Induction, chlorinated
      hydrocarbons                  524

   Detoxification of pesticides         526

   Induction, storage interactions      527

   Induction by drugs                528

   Induction, effect on blood
      levels                         529

   Induction, humans, need foi
      information                    530

   Detoxifying, diet, effect on
      toxicity                        532
   Activity, effect of
      Organophosphates,
      irritants, cold stress

   Physical factors, effect on

   fiperonyl butoxide, MDP
      compounds, effect on

   Effect of 3,4-benzpyrene,
      piperonyl butoxide en
533

534


540


544

548
   Fate of MDP compounds

   Mode of action of MDP compounds  554

   Mode of action of MDP compounds  560

   Compounds which may affect DNA  606

   Induction, testing                 660

EPIDEMICS
   Organophosphate insecticides       34
   Spillage of concentrated
      chemical into bulk food,
      water sources                  34

   UDT, halting of typhus epidemic    46

   Bacillus thuringiensis, use
      against caterpillars              217

   Organophosphate pesticides         234
   Spillage into bulk food,
      water suppl-                   234

   Or pesticide poisoning              307

   Legislation to handle pesticides,
      foods, separate in
      transportation                  308

   Of poisoning by pesticides          310

   Accidents, human environment      383

   Due to Naled, occupational
      exposure                      399
EPIDIDYMAL
   Dominant lethal test, mice          597
   Duration of spermatogenesis,
      mice                          597

EHLEPTIFORM
   Diene group pesticides              349
126

-------
                                 SUBJECT INDEX
  Occupational exposure, human.
effects, convulsions
DDT poisoning, animals
EQUirMENT
• Meal organic fungicides, uses
Costs of introduction of new
pesticides
Spr tying
Selection of spray
Spray, drift
Mosquito control
Spraying, drift
Occupational exposure, reduction
of
Transportation
Analysis of residues in food
Cleaning of
Act-on to improve protection of
public health
Improvement of
PCB s, uses
Sprav. parathion exposure
349
425
66
78
106
107
110
127
132
153
157
173
201
239
239
257
402
Programs to control pests
197
   Personal protecUon against
      exposure

ERECTION
   Organophosphates, skin
      contamination
   Hair erection

   Organophosphates, hair erection

ERADICATE
   DDT, pesticides after 1945

   DDT, malaria programs

   DDT, malaria programs

   Screw worm fly, programs

   Flies, programs
349

425


66

78
106

107

110

127
132

153

157

173

201


239
239

257

402

444


360
360

364


46

49

50

S2
164

EROSION
Metal salts removal of in soil
Factors affecting soil
persistence, wind erosion

Parathion, analysis in water, mud
Wind erosion, hazard to public
Termite control, possible
hazards
Needed information on pesticides
in air

Surface erosion, possible hazard
to aquatic environment
Dispersal of pesticide
ERYTHEMA
Morestan. production of
crythematous dermatitis
Chlorinated phenols
Dermatitis i'rom mixture of
paint cleaner and
pentachlorophenoi

Nitrogen compound?
Contact dermatitis, erythema

ERYTHROCYTE
Experimental oral exposure
to dieldrin
Effect on erythrocyte and
plasma chotinesterase
Experimental carbamate pesticide
Cholinesterase inhibition.
brain and erythrocytcs
Benzene hexachloride, effect of
fat diet on erythrocyte
cholincs Tase inhibiting
ability of parathion

ESTUARINE
Pesticides in

Waters

Waters, pesticides in

Chlorinated hydrocarbon
pesticides in
Pesticides in


45

143

144
145

195

195


196
202


364
364


364

365
365



301

301
410

410



532


118

120

121


129
171
                                                                            127

-------
                                   St'EIECT INDEX
   Pesticides in

   Recreational areas

ETHNIC
   Studies on pesticide* in blood,
      humans

   Ethnic differences, pesticide
      levels

EUTROPHICATION
   Lakes, eutrophkation of

   Lakes, eutrophic

EXCRETION
   Carbamate'. not in milk

   Of pesticides in cow's milk

   Of organochlorines in milk.
   DDT ingestion, DDA metabolite

   DDT ingestion, DDA metabolite

   Panthion, urinr

   Panthion exposure,
      patanitrophenol in usine

   Panthion, p-nitrophenol,
      humans

   DDT. rats

   Panthion exposure. p-.iitrophenol,
      humans

   Chlorinated hydrocarbons, DDT,
     m milk

   Panthion exposure, p-nitrophcnol
      in urine

   Temperature, effect on

   Storage of pesticides

   Of MDP compounds

   Piperonyl butoxide,
      3-4 benzpyrene

   Of MDP compounds

   Of MDP compounds
 208

 220



 148


 322


 118

 119


 64

 139


 269

 298

 299

 370


 373


 430

 431


433


437


448

533

S36

543


544

547

549
EXPLOSION
   Population explosion,
      reduction of

   Population explosion

   Beneficial insects,
      population explosion

   Organophosphatcs
   Gastrointestinal effects,
      diarrhea

EYES
   DDT, respiratory exposure,
      effects

   Organophosphates, effects

   Chemical compounds,
      uviution of

   Pesticides, effects on

   Organophosphates, effects on
   Diazii on poisoning, effects
   Bidrin, effects
   Caibamates, effects
   Chlorinated aliphatics, effects

   Paraquat, effects

   Occupational exposure, effects

   TEPP, effects

   Metaisosystox

   Organophosphates, effects

   Economic poisons, effects

   Preemploymcnt examinations

   Mercurials, effects in mice

FACE
   Occupational exposure, reduction
      of hazards, facemasks

   DDT, effect on sensitivity of

   Acute DDT poisoning.
      paresthesiasof face

   Organophosphates, face mask
   Protective equipment
   Personal protection against
      exposure
 25

179


207

361

361



296

361


365

366

367
367
367
367
367

368

383

406

414

415

442

443

664



153

298


359
128

-------
                                   SUBJECT INDEX
FALCON
   DDT, egg shell thinning in

   DDT. egg shell thinning in

   Faiiure to reproduce young

   Observations on

   Exposure to mixture of DDT.
      dieldrin

   Decline in population
   Implication of chlorinated
      hydrocarbon pesticides


FASCICULATION
   Organophosphosphorus compounds  369
   Early phase of poisoning,
      muscle fatcicuUtion

FATS
   DDT in salmon

   Carbamates, not cumulated in

   Pesticides in seeds

   Pesticide residues, diet

   Heptachlor epoxide in cows

   Chlorinated hydrocarbons in

   Chlorinated hydrocarbons in

   Pesticides in fish

   DDT in mammals

   Organophosphates in

   General population studies

   DDT in. rats

   DDT in, monkey*

   Dieldrin hi, dogs

   Dieldrin in

   DDT in

   DDT in. animals

   DDT. DDA in

25

179

210

211

212
437
437


369

369

13
64

133

136
139

155

156

210

213

234

255

264

265

266

267

268

272
299
DDT in

Methoxychlvr in

Dieldrin in

DOT, DDE i i. personal
variables
DDT in, socioeconomic
differences
DDT, place variables
Residues in
DDE, DDT, hcxachlorocyclohexanc
residues, humans

DDT in, humans

DDE in
DDT in
Paraquat poisoning, effect on
liver

DDT, dieldrin ir humans.
occupational exposure
Pesticides in, invironmental
exposure

DDT in

DDT in

DDT in

DDT, storage in

DDT in, rats

DDT storage, effect of sex ?

Pesticides in

Methoxychlor in

DDT in

DDT, storage in. animals

Chlorinated hydrocarbons,
storage, humans
Gamma BHC. rats
300

301

302


322

323
324
326

328

348

349
371

373


383

384

387

388

402

425

427

428

429

430

431

435


447
530
                                                                             129

-------
                                    SUBJECT INDEX
   Dfeldrin, DDT, effect of
      fats in diet
532
   MDP compounds, mode of action    555

FATAL
   Accidents, pesticide poisonings,
      children                       157

   Ingestion of poisons               251

   Pesticide poisonings, humans        305

   Pesticide poisonings, humans        306

   Host, pesticide poisonings
      humans                       308

   Statistics on, needed
      information                   309

   Clinical case reports               358

   Temik, effects, human             362

   Paraquat, effects, humans          370

   Paraquat poisoning, humans        373

   Occupational exposure             474

   Occupational exposure,
      airplane pilots                  445

   Cholinesterase inhibitors,
      effects                        450

FATIGUE
   Experimental dermal
      exposure to DDT               296

   DDT. effects                      298

   2,4-D, occupational exposure        350

   Anticholinesterase
      administration, effects          411

   Pilot, occupational exposure        445

   Cholinesterase inhibitors           446
   Symptoms of early effects          446

   Poisoning sy -ptoms, duiitrophenol,
      penuchlorophenol              450
    DDT, effect on dietdrir excrrtion    527

    Piperonyl butoxiJe, excretion
       in dogs                        547

 FETAL
    Deaths, dominant lethal test        59?

    Deaths                           598

    Mortality, methodologies for
       teratogenkity testing            658

    Laboratory techniques,
       needed to measure body burden  663

    Malformation, phenylmercurk
       acetate                        664

    Mortality                         667

    Mortality, trypan b'.ue in DMSO     669

    Blood levels. DD^, DDK            675
         FETUSES
            Examination for fetal
               malformations

            2.4,5-T; Affects in rats
                                    660

                                    666
FECES
   Excretion of Parathkm,
      metabolite in
403
   Methods, tentogenicity testing     667

FIBROSIS
   Paraquat exposure, pulmonary
      fibiosu                       370

   Safrole. effects in liver, rats        543

FIFRA
   Registration of pesticides           7
   Regulations of                    7

   Need to amend                    8

FINFISH
   Pesticides, industry concern        120
   Organochlorine-                  120

HNGER
   Organic mercurial compounds      362
   Paresthesias of fingers             ?62

   Chlorpronuzine. effect on
      finger pulse amplitude          418
   Sleep deprivation, effect on        418

FINGERNAIL
   Paraquat, diquat, effect on         365
130

-------
                                    SUBJECT INDEX
   Paraquat, diquat, effect on          405

FIRE
   Miiex, control of fire-ant            54

   Organochlorines, use for
      fire-ant control                  55

   Polychlorinated biphenyls,
      use in fire retardants            257

FISH
   DDT, metabolites in                9

   DDT in salmon                     13

   Dclaney clause, effects              14

   Toxaphene, effect on               18

   Persistent pesticides, effects on       49

   Substituted ureas, effect on          69

   MoDuscicides, nontoxk to           72

   Piscicides, effects                   73

   Pesticides in                      120

   Endrinin                         125

   2,4-Din                          126

   Chlorinated hydrocarbons in        136

   Pesticides in                      171

   Diquat, effects on                 205

   Lake trout, DDT effects            209

   Kills                             210
   Effects of pesticides in             210

   Piscicides. effects                  213

   Hazards to, organophosphates       234

   PCBiin                          257

   Pesticides, effects on, DDT in       357

   Pesticides in diet                  385

   Carcinogenesis in                  395

   Organochloiines, toxirity to         426
   Toxicity to, DDT, effect of
      nutrition                      431

   Enzymes in                       436

   Dirt, humans, residues in           537

   Methylmercury in, consumption
      by pregnant women             675

FLEAS
   Aldrin, use to control
      flea beetles                    51

   Commercial insect controllers       53

   Guinea pigs, infestation of          83

   Rice, DDT, control of fleas         85

   Potatoes, DDT, control of
      flea beetles                     87
   Vegetables, DDT, control of
      flea beetles                     87

   Tobacco, DDT, control of
      flea beetles                     ?9

   Pests, controlled by commercial
      pest control operators           150

FLOUR
   Contamination of grain, flour        157

   Endrin, contamination of flour      158

   Epidemics of poisoning             310

   BHC contamination of wheat,
      flour                          450

FLUKE
   POP, molluscicide to control
      snail carriers of larval
      human blood flukes             652


FOOD
   Chain, pesticides in                 8

   DDT, use in production of           9

   Residues in                       10

   Residues in                       11

   Standards needed, to reduce
      residues in                     12
                                                                                131

-------
                              SUBJECT INDEX
Containing chemicals,
carcinogenicity, Delaney
clause
Cooperative efforts needed to
develop pesticides for
production of
Lindane, use of near
Production programs, use of
pesticides in

DDT, use in production of

DDT, effect on production

Pest control

Factors influencing changing
use patterns

Repellents, uses

Toxicity testing, values, costs

Pesticides in

Accumulation in chains
Estuarine areas, production of

Water quality required for
products
Chain. DDD in

Pesticides from soil to plants

Transfer of pesticides from
soil to crops
Residues in
Survey of products
Bromide residues in
Of animal origin, source of
chlorinated hydrocarbon
residues

Exposure to pesticides
Pyrethrins, use
Contamination with pesticides
Contamination, accidents


14


19
23

46

48

49

S3


58

75

78

114

119
121


123
127

132


133
134
135
137

138

141
151
157
158
Containers, reuse of

Insect pathogens, ingestion of
Pesticides in

Chain, fish, wildlife in
Exposures, population
Measurements of pesticides in

Nontaiget organisms, use as

Chain, DDT in

Web, DDT in

Chain, accumulation of
materials in

Fish, pesticides in

Insecticides in

Loss of, residues in

Pesticides in, accidents
Contamination, control of

Residues

Epidemiological complexities
Carcinogens, teratogens,
mutagens in

Residues on, ingestion of

DDT in, ingestion of, human
Dieldrin ingestion
Epidemics of poisoning by
pesticides
DDT intake, dietary
Monitoring of residues
Pesticide spilled in.
accidental

Agricultural application of
pesticides
Pesticides in
DDT in, consumed by humans
159

163
170

171
172
173

180

187

188


192

210

212

220

234
239

2*0

250

262

263

298
301
310
326
357

383

384
385
394
132

-------
                                  SUBJECT INDEX
Pesticides in, needed studies
395
Contaminated with parathion,
   ingestion. human                428

DDT in, rats, effects                434

Presence of carcinogenic
   substance in                    464

Additives, route of
   administration                  465

Additives, use, conditions           467
Chemicals registered for use
   on food crops
Residues on
Effects of interaction on
   pesticide storage
Additives, mutagenic effect*.
   chromosome aberrations
469


470
Chemicals registered for use
   on food crops
Chemicals registered but not
   for use on food crops            470
Chemicals registered for use
   on food crops                  473
Chemicals registered but not
   for use on food crops            473

Chemicals registered for use on
   food crops                     474
Chemicals registered but not
   for use on food crops            474

Chemicals registered for use on
   food crops                     475
Chemicals registered but not
   for use on food crops            475

Residue, potential carcinogen        478

Needed information on human
   intake, synergists               511
512
Enzyme induction, needed studies
   on levels in food                519
525
Residues in, ingcstion. humans      537

Plperonyl butoxide, tolerances      543

Freons, use as propellants          545
   Additives, testing for
      irutagenicity in mice
            Ethylene oxide, fumigant
            Organophosphates
                                                                              598
            Recommended program for
               nutagenesis testing,
               pesticides used on crops         602
                                    649
   Pesticide residues in,
      organomercury compounds      664

FORAGE
   Methoxychlor, use on
      forage crops                    51

   Excretion of pesticides in
      cows milk                     139
   Resu'.ues, forage crops fed
      to cows                       139
            Arsenic, effect on forage crops      145

            Carbziyi. control of insects
               or. forage crops
                                    646


                                    200
         FOXES
            S;ath from pesticides
            Cereal seed dressings
               containing aldrin, dieldrin,
               heptachlor                     200

         FUMIGANTS
            Entrance into respiratory system    62
            Effects on insects                  62
                                             64
583
   Methyl bromide, hydrogen
      cyanide, para-dichlorobenzene,
      uses                           65

   Nematocides, action                70

   Hafogenated hydrocarbon
      nematocides                    71

   Volatile liquids, gases               198

   Soa                             205

   Soil                             206

   VS. pesticide production,
      annual                        315

   Chlorinated aliphatics               367

   Methyl bromide                   611

-------
                                    SUBJECT INDEX
   Application form
   Aciylonitrile, use

   Chloroform, use

   Ethylene oxide, use

   Paradichlorobenzenc, use

FUNGICIDES
   Pesticides after 1945

   Production, usage

   And bacteritides

   Inorganic
   Antibiotics
   Organic mercury compounds
   Metal organic
   Di'hiocarbamite

   Chlorine containing
   Miscellaneous

   Usage patterns

   Accidents, by industry,
      by occupation

   Seed furrow treatment

   Heavy metals in

   US. pesticide production,
      annual

   Organic mercury compounds,
      poisoning

   Cap tan, occupational dermatitis
   Difolatan, occupational
      dermatitis

   Occupationally related skin
      conditions

   Sulfur,  polysulfides and
      related compounds

   Used for seed treatment,
      poisoning

   Difolatan, occupational
      dermatitis

   Captan, folpet, difolatan
      teratogenic activity
645
645
646
649
651
46
47
65
66
66
66
66
66
67
67
147
155
199
202

315
362
365
365
366
368

383
399
438
Poisonings, occupational
exposure
Effects
Organic mercurial, mercury in
body fluids, diagnosis and
treatment of poisoning
Fcrbam, use of deferoxamine
in treatment of poisoning
Tested for tumorigenicity
Structure-activity-relations
Use in agriculture
Application form(F)
Captan, use
DCNA.use
FUNGISTATIC
Phenolic derivatives,
dermatitis
GARDENER
Educational efforts needed
Accidents, by occupation,
by industry
Educational efforts needed
Classes of applicators.
amateur gardeners
Inhalation of pesticides by
GARLIC
Herbicide for, economics of
Limited markets .
GASTRIC
Paraquat, ulcers
Gastric lavage, for poisoning
Intubation of mice
Papillomas, incidence of
GASTROINTESTINAL
Occupational exposure,
pesticides, effects
Organophospnates, effects
 442

 443



 448


 452

 490

 604

 610

 645
 645

 647



 365


 27


 154

 181


 194

480
 80
 80
373

450

484

486



351

361
134

-------
                                   SUBJECT INDEX
   Ttallhirn sulfate, effects           363

   Yellow phosphorus ingestion,
      effects                        371

   Chlorinated hydrocarbons, effects   372

   Crganophosphate, effects          411

   Ciganophosphates, occupational
      poisoning, effects              415

   Fteemptoyment examinations       443

   Occupational exposure, effects      449

   Needed research, enzyme
      induction                     S10

   Needed research, enzyme
      induction                     520

   Fat in diet, effect on storage
      of gamma BHC                526

GAVAGE
   Administration of compounds      667

GENETIC
   Giberellins, uses                   74

   Manipulation of pest
      populations                   219

   Need for perspective              261

   Kutagenicity of pesticides         567

   Importance of mutagenicity as a
      public health hazard           568

   Mutations                       569

   Defects                          570

   Mutations                       571

   Nettrospora, studies of
      attentions                    573

   Pnage and transformation          574

   Mutation induction by seed
      treatment                     576

   DraophOa testing in              SSS

   Cytogenetics and somatic cell       587
   Testing, systems                  589

   Classification of chromosome
      breakage                      590

   Host-mediated assay               594

   Dominant lethal test               596

   Adverse effects                   598

GENITOURINARY
   Diazinon poisoning, pathology      367

GESTATIOK
   Teratogcn icity. related to           658

   Tentogcnicity. period of           659

   Timing of cycles                  661
   Administration of chemicals
      during                        661

   Carbaryl. beagle dogs,
      teratogcnic effect               664
   Mercurials                       664
   Pheny! mercuric acetate,
      fetal abnormalities in mice       664

   2,4,5-T; rets, abnormalities         666

   Methods of study, mice            667


GIDDINESS
   Organophosphates, chronic
      exposure                      414
   Humans, effects                  414


GLAUCOMA
   Echothiophate iodide, use in        412

GLIOMA
   AWrin.dicldrin,
      occupational exposure          351

GLOMERULONEPHRITIS
   Aldrin, dieldrin, occupational
      exposure                      351

GLOVES
   Protective equipment              77

   Exposure, conditons               148

   Personal protective equipment      444
   Protective eoutpment              444
                                                                              135

-------
                                   SUBJECT IHDEX
GLUCOCORTICOSTEROID
   Organic phosphate insecticides,
      chemical irritants, and cold
      stress, increase plasma
      level of

GLYCOSURIA
   Occurrence during late acute
      and early convalescent
      stages of poisoning,
      organophosphates

GNAT
   Use of ODD against in
      lake water

GOATS
   Spraying of, with Sevin
   Sevin in tissue residues of
   Sevin in brain fat of

   Refractoriness to DDT

   Piperonyl butoxide toxicity to

GOGGLES
   Infonnation on product
      package labels

   Personal protective equipment
   Use while applying pesticides

GONAD
   Residue levels of chlorinated
      hydrocarbon insecticides in

GONADECTOMY
   Effect on storage of DDT, DDE
      in the rat

GOOSEBERRIES
   Residue reduction of malathion
      during food processing of

GOPHER
   Strychnine (alkaloid and sulfate)
      used in poison baits for

GRAIN
   Methoxychlor, uses

   Nitrite herbicides, use*

   Avicide*,uae

   Chtorinzted hydrocarbons

   Organophosphates in
533
373



126


139
139
139

426

542
 77

444
444
536
   Inorganic bromides in

   Contamination of

   Resistant plants

   Contamination of grain

   Avicides, hazards

   Epidemics of poisoning
      by pesticides
   Hexashlorobcnzene contamination
      of, human ingestion
 137

 157

 162

 200

 214


 311
   Hexachlorobenzene contamination
      of, human ingestion             364
372
   Piperonyl butoxide. tolerances on    543

   Pollen                           578

   Acrylonitrile, fumigant for         645

   Chloroform, fumigant for          646

   Dicamba, use for weeds in          647

   Hydrogen cyanide, fumigant for     649

   Linuron, use for weeds in           650

GRASS
   Use of benzoic add herbicides
      against                        68

   Use of aliphatic acid herbicides
428

141
72
51
70
73
135
136
against
Useofdinitroaniline
herbicides against
Use of organic phosphate nematitide
against soil insects and
nematodes in
Grasshoppers n. cattle in
Argentina
Bacteria spores used against
Japanese beet.es feeding on
Use of Dicamba on
Use of MH (maleic hydrczide) on
Use of Propham on
Useof Simazineon
69
70
71
91
163
647
651
653
653
 136

-------
                                    SUBJECT INDEX
GRASSHOPPERS
   Pests

   Rice pests
   Aldrin, use in control of
58

85
85
   Control of, by chemicals            91

   Insect pathogens, to control         163

   Endrin. use to control              648
GRAPES
   Monuron, control of weed
      seed lings in
651
GREKNHOUSE
   Occupational^ exposed workers     172

   DFP, behavioral changes in
      workers                       413

   Precautions for applying
      pesticides in                   444

   Plants grown in, mutagcnicity
      testing                        576

GROUNDNUT
   Oil seeds, use of chlorinated
      hydrocarbons                  90

GROUNDWATER
   Pesticides in                      144
   Leaching from soil                 144

   Study of pesticide levels in          169

GROVES
   Barriers to prevent pesticide
      movement                     199

   Workers it tangerine groves         365
   Difolatan dermatitis               365

GRUBS
   Aldrin, use to control               51

   Rotenone. use to control
      cattle grubs    '                63

   Cotton crops                      84
   Chlorinated hydrocarbon
      insecticides                    84
   Cydodtenes, use to control          84

   Cereal oops                       85
   BHC, use to control                85

   Bacteria, use to control             163
 GUERNSEY
   DDT. residue in cow s mill         139

 GUINEA
   Pigs, use to collect fleas             83

   Pig, use for allergy studies           399

   Rotenone, toxicity to
      guinea pig                    426
   Pig, metabolism of azinphosmethyl  426

   Ethyl fenthion, toxicity to
      guinea pig                    429

   Malcic hydrazide, tested in
      guinea pig, effects              642

GULLS
   Avicides, use to control             73
   Avitrol. use to control              73

   Toxaphene, mortalities in          211

GYPSY
   Moth, lead arsenate used to
      control                        45

   Moth, enforcement of quarantine     55

   Moth, insert pest                   58

   Moth, DDT use to control           60
   Moth, Sevin use to control           60

   Moth, imported parasites to
      control                       162

   Moth, DDT use to control          209

HAIR
   Organophosphates, topical
      effects                 ;       360

   Organophosplutes, effects          36*

   Chlorinated acW derivatives,
      2,4-D;2,44-T; effect on
      growth of                     365
   Thallium sulfate, loss of            365

   Sample skin matrix                405
   Hair dystrophy                    405
   Pesticides, effects  on keratin
      producing structures            405

   Chromosome aberrations, studies
      in stamen hair                  577
                                                                               137

-------
                                   SUBJECT INDEX
   Stamen hairs, studies              578

HALF-LIFE
   Of heptachlor epoxide, vs
      parent impound              133

   Of carbaiyl on cabbage and
      eggplant                      134

   Of Guthion on lemons and oranges  142

   Of dieldrin in blood of man         302

   Of captan in serum                603

   Determination of, need for in
      test animals                   660

HANDS
   Exposure to pesticides             112

   Exposure to pesticides             148

   Organic mercurial compounds,
      tremors of                    362

   Paraquat, diquat exposure          36S

   Chlorinated acid derivaties,
      2.4-D;2.4,5-T;
      hyperpigmentation of          365

   Persona] protective equipment      444

   Mercury poisoning, tremors of      448

HAPLOID
   Neurospora crassa as               573

   Pollen tubes used for chromosome
      analysis                      S78
   Pollen grain in somatic
      mutation  and chemical
      mutagen studies               578

HARES
   Killed by cereal seed dressings
      containing aldrin, dieldrin,
      heptachlor in England          200

HARVEST
   Residues of orgapochtorincs        63

   Metal organic fungicide*.
      treatment of harvesting
      equipment                    66

   TEPP, Phosdrin, Mevinphos,
      we on fruits, vegetable*         133
   Time factor
 134
   Dithiocarbamates, decomposition
      during                        137

   Fate of malathion residues          141

   Prperonyl butoxide, tolerances      543

   EndothaU, use                    648

HATCH
   Hatcnerics, protection of           121

   DDT suspected in fish
      population reduction           209

   Fish testing, contained DDT        210

   I»DE, cflect on egg hatch-ability.
      birds                         212
   DDE, effect on egg shells           212
HAWKS
   Population decline of

   Effect of DDT and dieldrin in
   Eye contamination,
      organophcjphates
211

212

665
   Effect of DDT on population
   Effect of Diddrin on
      population                    665

HAY
   Fumigants, bromide residue in       198
   Fed to cows, bromide in milk       198

HEADACHE
   DDT, effects on humans            298

   Acute pesticide intoxication         358
   Organochlorinc intoxication         358

   Acute DDT poisoning              359

   Signs and symptoms of
      intoxication, organophosphates   360
361
   Acute inorganic arsenical
      poisoning                     362
   Organic mercurial compounds       362
   Poisoning symptoms               362

   Oiganophosphonis compounds      367
   Eye contamination                367
   Poisoning with metaisosystox
414
138

-------
                                    SUBJECT INDEX
   Organc phosphorus poisoning

   Cholinesteraie inhibitors

   Mercury poisoning

   Poisoning, symptoms

HEART
   Fluoride rodenticides,
      effect on

   Occupational exposure to aldrin,
      dieldrin, effect on

   Diazinan poisoning, autopsy of

   Yellov/ phosphorus ingestion.
      effect on

   Pesticides, poisoning

   Hydr >gen cyanide, organism
      tested, dose, effect

HEAT
   Bacterial spores, resistant to

   Physical pest control methods,
      radiofrequency

   Radiant energy, pest control

   PCB s, in heat transfer agents

   DDT, testing for sensations

   Elemental pesticides, irritation

   Nitrophenols, effect on heat
      production mechanisms

   Temperature effects, parathion,
      sailn toxicity

HELICOPTER
   Aerial spraying from
   Needed engineering development

   Needed engineering development
   Aerial spraying

   Application of pesticides from

   Advantages, for applying
      pesticides
   Use for application of pesticides
   Particle movement from
415
446

448

449


72


3S1

367

371
446

641


163

165
167

257
297

369

Mosquito control, use in
HEMATEMESIS
Yellow phosphorus, ingestion

HEMATOCRIT
Occupational exposure to
pesticides
Pesticide usage, correlations

HEMATOLOGIC
Studies to assess pesticide
effects
Needed support for research

Lindane, disorders
Lindane, disorders
Effects of pesticides
Exposure to pesticides

HEME
Research needs
Studies on hrme synthesis
HEMOGLOBIN
Pesticide usage
HEMOLYTIC
DDT, use in non-hemolytic
jaundice
HEMOPOIESIS
Research needs
Effects on, exposure to
pesticides
127

371



351
361



16
16

34
233
371
392


240
240

35!


245

240

240
433
533
 23
 23

102
102

105
106
106
106
   Blood disorders, population
      comparisons                  372

HEMORRHAGE
   Anticoagulant rodenticides,
      death from                    72

   Gentian violet, effects             364

   Nitrophenols, effects              370
   Chlorinated hydrocarbons,
      animal deaths                  370

   Organophosphorus compounds,
      effects                        371
   Yellow- phosphorus ingestion       371

   Paraquat, poisoning               373
                                                                                139

-------
                                    SUBJECT INDEX
   Vitamin Kl.antidote

HEMOTOXICITY
   Biood dyscrasias, chlordane,
      gamma benzene hexachloride,
      parathion

   Pesticide exposure, discussion
      of findings

HEPATIC
   Research needs, detection of
effects of pesticides
Dieldrin, studies
DDT. effects on liver
microsomes
Paraquat poisoning
DDT, histological changes
Preemployment examinations
BHC ingestion, hepatic porphyria
Enzyme induction extra-hepatic
tissues, research needs
Enzyme induction
Research needs, enzyme induction,
extra-epatic tissues
Safrole, effects
3,4-benzpyrene. piperonyl
butoxide
HEPATOCARCINOGEN
Griseofuhrin
Safrole, tat
Freons, piperonyl butoxide
HEPATOMA
Griseofulvin, litter influence
Hydrazine, production of
hepatonus in mice
Mice, Freons, piperonyl
butoxide
HERBIODES
2,4-D, history
Pesticides after 1945
241
302
329
370
434
444
450
510
517
520
543
54*
485
543
545
485
492
545
44
46
4S1



388


392


241

302


329
370

434

444

450

510
517

520

543

54*

Number of chemicals, types
Contact
Systemic
Inorganic
Car joxylic aromatic
Phcnoxy
Betizoic acid
Phthalic acid
Phtiialamic acid
Aliphatic acid
Substituted phenol
Heterocyclic nitrogen
derivatives
Aliphatic organic nitrogen
Substituted ureas
Carbamates
Other amides
Dinitroaniline
Nitrite
Miscellaneous

Limited markets

Usage of, 1964
2,4-D; removal from water
Tentative guidelines
2,4-D; study

Water concentrations

Daily intake

In diet; 2,4-D; PCP
67
67
67
67
68
68
68
68
68
69
69

69
69
69
69
70
70
70
70

ao

104
123
124
126

128

135

136
                                               Acceptable daily intake,
                                                  FAO-WHO                     137

                                               Usage, 1968, house and garden,
                                                  agriculture        !             147

                                               Accidents, by industry,
                                                  by occupation                  154

                                               Drift of, in air                     195

                                               Granules, pellets, use of             199

                                               Drift, reduction of                 201

                                               Effects on target, non-target
                                                  organisms                     203
                                               2,4-D                            203

                                               2,4,5-T, persistence                204
140

-------
                                SUBJECT INDEX
Use of
Paraquat
Diqutt
Poisonings, humans
Morbidity effects of
occupational exposure
Phenoxy chemicals, 2,4-D;
2,4.5-T
Nitrogen compounds, effects
Occupationally-related skin
conditions
Occupational exposure,
California
Effects of
Paraquat, effects
Tumorigenicity testing, ratings
Substituted urea . induction
of hepatic microsomal
erzymes
S true lure-activity-relation
Use in agriculture
Atratrone, experimental
Application form (H)
Chlorpropham
Endothall
Naptalam
PCP
Fkophftin
IRBTVORES
Solar energy, use by
Food web
DDT residues in
205
205
205
307
347
350
365
366
442
443
446
490
518
604
610
645
645
646
648
651
652
653
186
188
188
HERBS
   Chemicals applied to              381

HISTOLOGIC
   o,p'-DDD, effects, humans         301
   Endrin studir, monkeys           410

   DDT, DDE, effects in rats, sex
      differences                   428

   DDT, effects                     434

   Changes, DDT, chlorinated
      hydrocarbons                 436

   Pathologic evaluation             466

H1STOPATHOLOGY
   DDT, rod-nts, liver               424

   DDT, rats, liwr                   434

   DDT, monkeys, liver              435

HOARSENESS
   Chronic arsenical poisoning         363

HOGS
   Examination rf, for Sevin
      residues                      139

   Storage of dieldnn in fat           265

   HEOD in vs intake                279

HONEY
   Bees, susceptibility to
      carbaryl                      208

   Solvent for 2,4,5-T               666

   Solvents for compounds           667

   Solvent for compounds            674

HORMONES
   Plant, research on                 44

   Juvenile                         83

   Juvenile                         165

   Developmental pheromones         219

   Sex, effect on toxicity             428

   Auxin analogs                    604

HORNWORM
   Tobacco pests, DDT control         89

   Ught traps, effect on tobacco
     hornwonn population           166
                                                                           141

-------
                              SUBJECT INDEX
HORSE
   Africa, Und, use of
91
Inhalation of pesticides

DDT, DDE in serum, comparison
                                       263
HOUSEFLY
Resi?»i;ice to DDT, 1946

Disease vectors
Sterilization
Fate of MDP chemicals in
Metabolism of MDP compounds in
Metabolism of piperonyl
butoxide, tropital in
Metabolism of chemicals in
Metabolism in

HOUSEHOLD
Needed information on
exposure from UiS
Mcthoxychlor, use*.

Dieldrin, uses

Commercial pest control industry
Pyrcthrin. allethrin uses

Needed information on exposure
from use
DDT in meals

Excessive use, pesticides

Use of pesticides
Materials, to reduce pests

Usage

Safety precautions ignored

Use of, population groups

Commercial pest control

Insecticides for use

Incorrect disposal of containers
Storage of, protection of
children

Aerosols, inhalation of

59

164
164
548
549
549
555
560



23
51

52

53
63


102
114

132

145
146

147

148

149

150

151

159

160

201
with household dust

Pesticides, effects on skin

Insecticides, studies on
asthma, bronchitis,
sinusitis
Annual DDT plus DDE intake
DDT, DDE in diets
Haz.irdous Substances Act
Detergents, interaction with
pesticides, need for study

Enzyme induction studies
needed
Formulations, contain MDP
compounds

Detergents, interaction with
pesticides, need for study
Exposure to pesticides, tissue
residues

Exposure to pesticides
Use, synergist with pyrethrum,
control of pests

Use, need for mutagenic
evaluation
DDT, use
Dichlorvos, use

Lindane, use
^,
Paradichlorobenzene, u«

HUMAN
DDT, DDD, uses, evaluate for
health hazard

Body burden, residues, need
for surveillance of
Need for clearinghouse of data

Research support needed to assess
toxic effects
327

363


370
384
385
480

511


519

526


531

537

538

541


611
647
647

650

651



8


13
15


16
142

-------
                               SUBJECT INDEX
Needed regulations to protect
   health                          IS

Lindane, need to discontinue
   exposure                        23

Controlled exposure                 34

Organophosphates, residues          35

Control of diseases                  SO

Organochlorines, effects             56

Phthalamic acid cr npounds,
   safety in                         69

Carbamates, safety in                70

Rodrnticides, effects                71

Plant growth regulators.
   toMcity                         74

Parathion, deaths                   81

Lindane, need to discontinue
   exposure                       102

Potential exposure hazards          112

Water route, exposure              123

Direct spraying                     126

Systemic vs surface-type
   pesticides, exposure             132

Time factor, residues in food        134

Residues in beef, consumption of    138

Endrin contaminated bread,
   effects                         158

Accidental incorporation of
   pesticides in animal feed,
   effects                         159

Pesticides in food and feed          170

Pesticides in people                 172

Antibiotics, effects                 203

Viruses, pathogens, insect
   control                        217

Controlled exposure                233
 Residues, disease                  234

 DDT, enzyme induction            235

 Needed information, effects on
    health                         238

 Action to improve protection
    of public Health                 239
 Development of baits, reduction
    of hazard                      239

 Pesticide protection teams,
    reporting system for
    poisonings                     241

 Epidemk>!ogjcal complexities       251

 Single pesticide-single disease        254

 General population studies          2SS

 Case reports                       256

PCB i, r.eed to examine tissues.
    fluids                          257

DDT administration                 264

HEOD in                          265

HEOD in                          266

Organochlorites, adipose            269

p,p'-DDE in blood                 273

Controlled exposures               295

Agent factors, pesticides
   in poisonings                   307

Host, pesticide poisonings           308

Pesticide residues                  319

PCB s. adipose                     320

DDT. DDE, adipose, blood          321

Djeldrin, DDT, residues,
   sex differences                  322

Socioeconomic differences,
   residues                        323

Time variable. DDT residues         325

Dietary sources, body
   burden DDT                    326
                                                                               143

-------
                            SUBJECT INDEX
Monitoring survey, pesticide
residues in adipose

Monitoring data, pesticide
residues in adipose

Monitoring data, pesticide
residues in adipose

Monitoring data, DDE in adipose

DDT, dieldrin, adipose

DDT, dieldrin, adipose

p,p '-DDE, dieldrin.
DDT, adipose

p.p '-DDE, dieldrin, DDT,
adipose

Dieldrin, effects

Poisoning by pesticides
Residues, monitoring

Clinical case reports
Chlorinated hydrocarbon,
liver effects
Pesticides in milk
DDT in milk
DDT in milk
DDT in fat
DDT exposure, effects
DDT. foods, consumption

Paathion exposure,
decontamination of skin
Panthion hydrolysis
Percutaneous penetration studies

Radfolabekd materials, studies

Hair follicles, effect of
Fekema ES-30-9

DDT, DDE stoats

Captan, rnutagenicity

331


332


335

337

S38

339


340


341

349

356
357

358
372
373
374
385
387
390
39


400
401
402

404


405

429

438
Oir.'cal diagnostic techniques

Milk, pesticides in

Evaluation of carcinogenic
hazards

DDT carcinogenicity, need for
:nore research

Legislative needs

Monitoring survey

Intake of syncrgists, need for
further studies

Studies, organophosphates.
interactions

Dimetli^dtc degradation

Eiuyme induction methodology
needed
Residues of persistent
pesticides
Orfttnochlorines in tissues
Dieldrin, in diet
Phenobatbital, effect on
levels of •.hlorinated
'.ydrocarbons
Enzyme inducing agents, effect
on renducs
Factors determinun- storage
DDT in
Piperonyl butoxide. safe
toleruice for ingestion

MDP compounds metabolism
Dominant lethal test
Recommended program for
mutagenesis testing

Chemosterilants, exposure

Compounds known to alter DNA,
exposure to

Chlorinated hydrocarbons.
exposure
447

449


464


471

•180

496


511


512

514


520

525
526
528

529
530
537
538

542

547
596

603

604


605


610
144

-------
                           SUBJECT INDEX
Captan, embryo, mutagenicity
   testing
       HYDROXYLATION
639       Organophosphates in rats.

PCP, use in schistosomiasis
control
Expotuie to teratogen
Population monitoring
Studies
Chlorinated hydrocarbons in
mflk

Organophosphates, teratogenic
studies

HUMIDITY
Residues in environment

Fungi, conditions required for
insect pathogens

Environmental factors
Effect on toxicity, therapeutic
effect of chemicals

HUNGER
Pesticides, use to improve food
technology, production

DDT ingestion, condition of
human

HYBRID
Barley seeds

Strain of mice, effect of
2.4,5-Tin

Mice;2,4,5-Tin

HYDROLYSIS
Of orsanophosphites, on plants
Of pesticides, soil moisture
Of ndkriabded materials
Product of orguophosphates,
pwtropncnol
Of phospborylated oximes
Of bBrthrio, nta, rabbits
Of onanooh.>SDhates


652
€59
661
674

674


675


145


163

249

534



304


430


577


666

667


133
144
401
448
453
547
608
inhibition of testosterone

Metabolism of MDP compounds
Metabolism of MDP compounds
Metabolism of MD? compounds
HYGIENE
In industrial plants

Occupational exposure,
industrial hygiene

HYPERAcnvrrY
Barbiturates, to control

HYPERBARIC
Microsomal enzymes, effect of
oxygen exposure
Organophosphate poisoning.
use of hyperbaric oxygen
HYPEREMIA
Contamination of eye by
organophosphorus pesticides

HYPEREXCITABIIJTY
Chlorinated hydrocarbons,
poisoning symptoms

HYPERGLYCEM1A
Organophosphorus compounds,
changes found

HYPERPIGMENTATION
Phenoxy herbicides, 2.4-D,
2,4,5-T, occupational
exposure

Chlorinated acid derivatives.
occupational exposure
HYPERPYREHA <
Chlorophenols
HYPERSECRETION
Organophosphorus compounds,
poisoning, effect on
bronchial fluid secretion
HYPERSENSmVITY
Single pesticide, single
disease
DDT, fleets on
533

549
554
560

153


252


425



534

534


361



446



371




350


365

450

369

254
298
                                                                     145

-------
                                SUBJECT INDF.X
   Uncertainty in poisoning
      diagnosis                     449

HYPERTENSION
   DDT residues, association with      329

   Chlorinated hydrocarbons, effects
      on cardiovascular system        370

   Organophosphonis compounds,
      effects                       371
   Pesticide residues in
   Hazards to use
HYPOTHALAMUS
   Brain centerf stress changes
      in behavior
IMPURITY
   feticides, technical grades
      contain impurities
391
391
   Poisoning, signs and symptoms      449

HYPERTHERMIA
   Treatment of poisonings, use of
      cold water                    451

HYPERTROPHY
   DDT, liver changes               434

HYPERBARIC
   Mkrtsomal drug metabolism,
      inhibited by hypoxia           534

HYPOPLASIA
   Blood dyscrasia                  388

HYPOTENSION
   Organophosphorus compounds,
      effects on cardiovascular
      system                       371
409
HYPOXIA
   Mfcrosomal drug metabolism,
      inhibition by hypobaric
      hypoxia                      534
249
   Lindane. occupational exposure
      to impurity in
      (delta-heptachlnro-
      cyclobexane)                 363
   Malathion sample, impure.
      effects on cats, dogs
523
INCOORDINATION
   Organic mercurial poisoning,
      signs                        362

   Mercury poisoning, signs           448

INDUCTION
   Of enzymes                      305

   Of enzymes, DDT, phenobarbital    329

   Of enzymes, organophosptutes      348

   Of enzymes, DDT                 356

   Of enzymes, DDT                 357

   Of enzymes, DDT, phenobarbital    434

   Of enzymes, chlorinated
     hydrocarbon pesticides          435

   Of enzymes, chlordane             43*

   Of tumors, judged positive,
     judged negative                468

   Of rumors, compounds judged
     not positive                   469

   Of tumors, compounds judged
     positive                      47C

   Of enzymes, needed tests for
     pesticide studies               S10

   Of enzymes, pesticide
     interactions                   516

   Of enzymes, types of chemicals
     producing                     517

   Of enzymes, organophosphates      518

   Of enzymes, tests for new
     pesticides                     519

   Of enzymes, need for data          520

   Of enzymes, chlorinated
     hydrocarbons                  521

   Of enzymes, storage interactions     527

   Of enzymes, DDT                 528

   Of enzymes DDT, phenobarbital    529
146

-------
                                SUBJECT INDEX
   Of enzymes, effect on storage
   Of enzymes, MDP compounds
   Of enzymes
   Of chromosome changes
   Of dominant lethals, negatke,
     captan
   Of dominant lethals.
     negative, DDT
   Forward mutation, linuron
   Recessive lethal, maleic
     hydnzide
INFANTS
   Pesticide poisonings in
   Parathion ingestion by
   DDT ingestton of, breast fed
   DDT in
   Age at start of experiments
   Chlorinated hydrocarbons in
   Mercurials, production of
     infantile cerebral palsy
INFRARED
   Use to control insects
INGESTION
   By insects, stomach poisons
   Modes of entry of pesticides
     into body
   Potable water supply
   Limits, standards, pesticides
   DDT, ODD, DDE, residues in
     cow i milk
   Accidents in children,
     pesticides
   Of pesticides, accidents in
     children
   Insect pathogens, ingestion
     in food, water
S30

541

554

596


639

640
642
642

158
308
374
386
484
674

675

166

61


112

122
122


140

157


158

163
Of pesticides, epidemiologica!
complexities

Of pesticides, accidental

Case reports

Of chemicals, humans, in food,
dsinks

Of pesticides, routes of entry
Of organochlorines
OfHEOD
OfDDT.HEOD
OfHEOD, rats, concentration
m tissues
Controlled human exposures
Of DDT, experimental, humans
Of DDT, J.vmans, effect on lice
Of DDT, humans, effects
Of dieldrin, humans
Of pesticides, children, deaths

Of parathion, child
Of DDT, humans, time variable
Of organophosphates, effects

Of hexachlorobenzene. production
ofporphyria

Clinical case reports

Of organophosphorus compounds.
effect on gastrointestinal
system

Of inorganic anemcals, effects
Of thallium sulfate, children
Of hexachlorobenzene, humans.
effects

Of nitrophenols, effects
Of Paraquat, effects

250

251

256


262

263
264
265
267

284
296
297
298
299
302
306

308
324
347


350

358



361

362
363

364

368
370
                                                                             147

-------
    Of yellow phosphorus, effects
    Of Paraquat, effects
    Of chlordane, effects
    Of Paraquat, effects
    Of DDT, breast-fed children
    Of pesticides, poisonings
    Of DDT
    Of aldrin, monkeys
    Of poisons, children
    Of DDT, humans, effects
    Of pesticides, need for
       protection
    Of DDT. humans
    Of BHC, humans
    Of household detergents,
       interaction with pesticides
    Of pesticide residues
    Of other chemicals, possible
       interaction with piperonyl
       butoxide
    Of piperonyl butoxide, effects
    Of pesticides, terting
    Of pesticides, humans
    Of pesticides, testing
 INHALATION
    Of pesticides, routes of entry
    Of ak. DDT in
    Of pesticides, occupational
       exposure
    Of pesticides, accidents
    Of household pesticides
    Of pesticides, case reports
    Of pesticides, routes of entry
SUBJECT
37!
371
372
373
374
383
390
410
417
430
443
'47
450
526
537
541
542
567
611
657

112
114
153
158
201
256
263
INDEX
Of DOT. humans
Of DDT, humans
Of pesticides, clinical case
reports
Of nitrophcnols
Of pesticides, protection
Of DDT, humans
Of chemicals, evaluation of
carcinogenic rraards
Of pesticides, home owners,
need for legislation
Of synergists, effects,
information needed
Of MDP compounds
OfFreons
Of household pesticides, need
for mutagerucity studies
Of household pesticides,
need for mutagenic
evaluation of
INTERACTIONS
Little knowledge of
Need for study of
Of DDT and trichinosis, rats
Need for evaluation of DDT
with or by other materials
Summary of
Conclusions of
Definition of
Of pesticides, through
inhibition of esterases
Summary of
Of pesticides, through alteratii
nffi^miitf* micvo^nmst £iizi
w( ncjmiit* iiuuujwiiuu viicj
activity
Summary of
296
298

358
370
443
445

464

480

511
541
545
602

611

 81
419
429

471
509
510
511

512
515

516
521
148

-------
                                 SUBJECT INDEX
   Of pesticides at target level         523

   Summary of                     S24

   Relation to tissue storage of
      persistent pesticides            S2S

   Summary of                     530

   Exogenous physical factors
      influencing pesticide
      toxicity                      531

   Effect of diet                    532

   Effect of temperature             533
   Effect of radiation                533

   Other physical factors             534

   Of pesticides with synergists        540

   Of MDP compounds              546

   Testing for, recommendations
      for mutagenkity testing         603

   Statistical analyses                668

INTESTINE
   Experimental oral exposure
      to methoxyrhlor              301
   lUopsy of small intestine           301

   Castro-intestinal effects of
      organophosphorus compounds   361

  'Paraquat, absorption from
      intestine                      370

   EDTA. treatment of heavy
      metal poisoning                451
   delation in intestinal lumen,
      oral administration             451

   Interactions, by interference
      with intestinal absorption        511

   Organochlorine compounds,
      effect of fat diet on
      absorption from intestines       530

   Effect of fat diet on toxicity
      of benzene hexachkmde,
      absorption from intestines,
      rats                          532
INTRAMUSCULAR
   Poisoning by heavy metal
      derivatives                    4S1

   Dimercaprol, IM. in treatment
      of poisonings                 452
   EDTA, IM. in treatment
      of poisonings                 452

INTRAPERITONEALLY
   Treatment of carbamite
      poisoning                    410

   MDP compounds, route? of
      administration                544

   Mutaton studies, host
      mrdiated assay                594

INTRAUTERINE
   Tests for; malformations           600

INTRAVENOUS
   Study of chemicals, metabolites     403

   Injec'ion of acety Icholine,
      we in schizophrenics           413

   Injection of parathion, effect
      of temperature on toxicity.
      mite                         432

   Of EDTA, treatment of heavy
      n> - tal poisonings              452

   Injection of MDP synergists,
      rats                         543

   Injection of MDP compounds,
      with 3,4-benzypyreiie          544

   Injection of MDP compounds,
      metabolites in urine,
      rats                         547

INTUBATION
   Route of administration           483

   Oral intubation, repeated doses     484

   Oral route, maternal metabolism    486

IRRADIATION
   Sterility induced by              164

   Sterilization, induced by           166
                                                                              149

-------
                                  SUBJECT INDEX
    Exposure of rats to
       X-inadution                   533

    Chromosome studies               587

    Dominant lethal test               596

 JAUNDICE
    DDT, use in treatment of
       unconjugated
       non-hemolytic jaundice          24S

    DDT, use in                       300

    Yellow phosphorus ingestion,
       effects                        371

    DDT, use of in treatment of
       unconjugated nonhemolytic
       jaundice                       436

 JUVENILE
    Hormone, effect on insect
       reproduction                   83

    Hormone, sterilization of
       insects                        165
    Precautions for use                 16S

    Hormone, uses, precaution*         219

 KERATIN
    Propellants in pesticide
       aero«ol dispensers.
       cornea! injury                  368

    Pesticides, effect on                405

 KIDNEY
    Pesticides, effect on fish             210

    Function, pesticide exposure         351

    Ingestion of yellow phosphorus      371

    Chlorinated hydrocarbons,
       effects                        373

    Panthion metabolism, humans      430

    DDT in, starvation                 431

    Captan. effects on                 438

    Chlorinated hydrocarbons,
       effects                        447
   Research needed, enzyme
      induction                     510

   Research needed, enzyme
      induction                     520

   Chlorinated hydrocarbons in        536

   2,4,5-T; production of
      cystic kidneys, mice, rats        666

KILLS
   Pyrethrum, use against insects       44

   HCN, effect on red scale insect      45

   Stomach poisons, effect
      on insects                     61

   Rotenone, mode of action          63

   Contact herbicides, mode of
      action                        67

   Aliphatic acid herbicides, uses       69

   Nematocides                     70

   Thiophcne nematocides, mode
      of action          .           71

   Rotenone, effect on fish           73
   Toxaphenc, effect on fish           73

   Labeling of pesticides              76

   Biological control, scale
      insects                        82

   Residues in animal tissues           138

   Commercial pest control           152

   Endrin contaminated bread,
      effect on rat                   158

   Pesticide treatment, goals           161

   Insect pathogens                  163

   Juvenile hormone, rffects           165
   Radiofrequcncy electromagnetic
      energy                        165

   High intensity «?nic, ultrasonic
      energy, effect on pests          167
150

-------
                                 SUBJECT INDEX
   Repellants, toxicants, effect
      on mice                        200

   Herbicides, effect on i.ontarget
      organisms                      203

   Plant growth regulators             205

   Insecticides and miticides           206

   Dieldrin, effect on fish, crabs        209
   DDT, effect on crabs               209
   Baytex, endrin. effect on
      crab larvae                     209

   Fish                             210

   Rodenticides, effect on cats         214
   Avicides                          214

   Soil preparation, effect on
      insects                        218

   DDT ingcstion, human, effect
      on lice                        298

   Accidental deaths, residues in
      humans, ethnic differences       322

   DDT residues in humans            329

   Chlorinated hydrocarbons,
      animals, symptoms, effects       370

   Parathion ingestion, children        428

   BUdR, effect on Chinese
      hamster cells                   S88

   Bipyridylium quaternary salts,
      effect on plants                607

KITTENS
   DDT. DDE blood lewis in         1'8

LACRIMATION
   Organophosphates, signs and
      symptoms of intoxication        360

LAKES
   DDT. DDE  metabolites in           9

   Contamination by DDT            13

   Use of rotenone to kill
      undesirable fish                73

   Pesticides, run-off into              116
   Pesticides in Lake Michigan         119

   Pesticides in, endrin in             125

   ODD application to               126

   Needed studies of pesticides in      169

   Need for monitoring of            171

   Application of pesticides,
      avoidance of                  196

   Contamination of by Dinoseb,
      effects on aquatic organisms     203

   Trout in, effect of DDT on         209

   Toxaphene, use in, effects          213

LAMBS
   Dieldrin, residues in               265

   Concentration of dieldrin in
      fat, vs concentration in diet     279

LAMPREY
   Baytuscide, to control              72

   Lampricide L-30-F, to control
      lamprey populations            73

LAPAROTOMY
   Embryo's obtained by      ...      661

LARVAE
   Aldrin, use to control com
      rootworm larvae               52

   Control, Department of Defense     54

   Mosquito, use of Abate as
      replacement for DDT           60
                       f
   Coiton crops, use of
      cyclodiencs to control          84

   Cereal crops, use of BHC           86

   Oil seeds, use of toxaphene         90

   Bndworm; particle axe. effects     111

   Mosquito; 2,4-D effect on         126

   Control of alfalfa caterpillar        163

   X-rays, gamma rays, effect on       167
                                                                              1S1

-------
                                  SUBJECT I\OEX
    Organochlorines, effect on
        marine invertebrates            208

    Blue crabs, effect of DDT on        209

    Trichina, effect olDDT. rats        430
  LARVICIDE
     Pesticides before 1945               44
     Petroleum oils, use as               44

     DDT, use as                        48

  LAWNS
     Needed information on exposure
        to pesticides used for             23

     Dieldrin, use foi insect
control on
Chlordane, uses on
Herbicides, uses on
Metal-organic compounds, uses
Needed information on exposure
Commercial services, use on
Granules, use of by homeowners
2,4-D, use on
LD-50
Acute, definition of
Dermal, indicative of human
poisoning
Acute oral, phosphate ester
pesticides
Acute dermal, phosphate ester
pesticides
Acute oral, chlorinated
hvdnwfann twcficufec
iijrtH^AiviiMjit I^BUVMBO
Acute dermal, chlorinated
Hydrocarbon pesticides
Of pesticides
SJrfo
Effect of DMSO on Seman
Carbamates
52
53
67
68
102
197
199
646
259
307
312
312
313
313
382
402
403
410
   Acute dermal, occupational
      poisoning vs acute oral          423

   Of pesticides                     425

   Acute oral. DDT, rats              428

   Hale vs female rats                 429

   Dermal, dieldrin, rats              430

   Useof atropinc in
      cholinesterase poisoning         452

   Use of oximes in poisonings         453

   Use of tetraethylammonium
      chloride in carbamate
      poisonings                    454

   Organoptiosphates                 518

   Effect of 1'iet on                   532

   Oral toxicity of pesticides          645

   Oral toxicity of pesticide \          M6

   Oral toxicity of pesticides          647

   Oral toxicity of pesticides          648

   Oral loxitity of pesticides          649

   Oral toxicity of pesticides          650

   Oral toxicity of pesticides          651

   Oral toxicity of pesticides          65 2

   Oral toxicity of pesticides          653

   Teratogenicity testing              660

LEGUMES
   Chlorinated hydrocarbon
      pesticides, dietary
      intake from                    135

   Residues of herbicides in           137

   Crop rotation                     218

LESIONS
   Difolatan, occupational
      exposure                      365

   lOpafbx, neuron*!                 413
   Pesticides, neurological             413
152

-------
                                  SUBJECT INDEX
   Liver, DDT. chlorinated
      hydrocarbons                  435

   Testing procedures.
      carcinogenic hazards            465

   Characteristics of
      carcinogenicity                 478

   Piperonyl butoxide, effects in
      livers, animals                  S42

   Chromosome effects               592

LETHAL
   Pesticides, effects on humans       113

   Use of radiofrequency, effects
      on insects                      166

   Effects on marine life              210

   Dieldrin, DDT, studies in
      birds                          212

   Genetic manipulation of
      pest populations                219

   LD-SO definition                  2S9

   Warfarin, effect of temperature
      on toxicity                    433

   Mutations, effects                  569

   Plants, effects, detection
      in microspores or pollen         575

   Mutation induction by
      seed treatment                 576

   Drosophila, testing for
      mutations                      586

   Dominant lethal test               596

   Summary of mutagenicity
      testing                        601

   Recommended program for
      mutagenicity testing            602

   Captan, negative induction
      of dominant lethals             639

   DDT. negative induction of
      dominant lethals                640
   Formaldehyde, low incidence
      of recessive lethals             641

   Maleic hydnzide (MH), no
      recessive lethal induction        642


 LETHARGY
   o,p -ODD, effects in humans        301

 LEUKEMIA
   Radiation exposure, effects        255

   National Death Index,
      etiologies of                  498

 LEUKOPENIA
   Blood dyscrasias, pesticides
      associated with                388

 LICE
   DDT ingestion, human, effect
      on Ike                       298

   Parathio^, use as treatment for      311

   Chlorinated hydrocarbons         363
   Lklane, use for control of         363

 LIPID
   Model, use of in study of
      dynamics                     271

   Metabolism of, in fat cell,
      interpretation of               272

   Metabolism of fipid-soluble
      compounds, different animals    426

   DDT, toxicity, effxt of fat
      in diet                        431

   Dieldrin, effect of dietary
      protein                       432

   DPT, formation of inclusion
      bodies                        434

   Sesame oil, use as lipid
      vehicle in cancer research        543

LIVER
   Orgmochlorines, effect on         33

   Enzyme induction, DDT           36

   Effect on, pesticides, fish           210
                                                                               153

-------
                                  SUBJECT INDEX
     Enzyme induction. DDT            235

     Enzyme induction, DDT            246

     Presence of pesticides in            248

     Cod liver ofl, analy sis               25 7


    Cancer, occurrence                262

    Dieldrin in correlation with
       blood levels                   267

    HEOD in. rats                     269

    HEOD in, rats vs concentration
       in blood                       285

    HEOD in, rats, during
       post exposure period           293

    Function tests. DDT exposure.
       humans                       299

    DDT, use to decrease scrum
       bilirubin                       300

    o.p-DDD exposure, humans        301
    Mcthoxychlor exposure, humans    301

    Pesticide levels and disease          329
    Residues of DDT                  329

    Organophosphates, chronic
       exposure                      348

    Function tests, pesticide
       exposure                      351

    Ingcstion of yellow phosphorus.
       effects                        371

    Chlorinated hydrocarbons. DDT.
       effects                        372

    Organophosphorus compounds,
       effects                        373

    Pesticides in body tissues           385

    Enzyme induction, pesticide
       exposures                     388

    Cirrhosis of. pesticide levelt         391
    Disease, organochloride
       pesticides in                   391
 PesticiJe exposure, behavioral
    changes                       409

 DDT, effects on, rodents           424

 Chlorinated hydrocarbons, DDT.
    effects on, rodents             425

 Azinphosmethyl metabolism        426

 Microsomal activity, neonates       427

 Cell morphology, DDT, sex
    differences                    428
 Metabolism of Azinphosmethyl
    and EPN. sex differences,
    rodents                       428

 Damage by carbon tetrachloridc,
    effect on methoxychlor
    toxicity                       430

 Microscmal activity, starvation      431
 Storage of DDT, rats, starvation      431

 DDT, effect on storage of
    Vitamin A                     432

 Chlorinated hydrocarbons,
    effect on                      434

 Chlorinated hydrocarbons, DDT.
    effect on, rats                  435
 Chlorinated hydrocarbons,
    effect on weight, fat
    content                       435
 Induction of microsomal
    enzymes                      435

 Microsomal enzyme changes.
    structural changes              436

Chlorinated hydrocarbons,
    effects                        447
                /
 2.4-D; 2.4.5-T effects on            450

Anticoagulant rodentitides,
   effect on                      451

 Enzymes, newborn mice vs
   adult mice                     484

Organochlorines in, disease
   vs controls                     495

Cancer                           497
154

-------
SUBJECT INDEX
Enzyme induction

Alicstcrase, studies needed
for anticholincsterase
pesticides
Aliesterase, metabolism of
parathion
Aliesterase. need for studies

Enzyme induction

Enzyme induction
Enzyme induction, chlorinated
hydrocarbons

Chlorinated hydrocarbons.
enzyme induction

Enzyme induction

Enzyme induction
Enzyme induction, MDP compounds
Pyrethrum, effects on, rats

Microsomcs, metabolism of
MDP compounds

Microsomal mixed function
oxidases

Microsomal enzymes, metabolism
of MDP compounds
MDP compounds, tffec: on
microsomes
LIVESTOCK
New pesticides, uses
Botanical insecticides.
rotenonc, uses
i
Miscellaneous insecticide
compounds, fly sprays, uses
TEPP, spraying, effect on

Accidental incorporation of
pestkides in animal feed
Pesticides in food and feed

Use of pesticides
S09



S13

514
514

517

520

524


527

530

533
541
544


548


554


555

560

59

63

65
110


159
170

196
Hazard to. cereal seed
dressuigs. treated

DicMorvos, u
-------
                                 SUBJECT INDEX
    Population studies, comparison      372

    MOP compounds, tumors of        543

 LYMPHOMA
    Piperonyl butoxide, mice           492

    National Death Index              498
 MAGGOT
    Aldrin for control of              651

 MAIZE
    Cereals                          85
    BHC for control of pests           85

    Losses due to insects              87

    Mutation induction by
       seed treatment                 577

    Locus in. determination of         578

 MALAISE
    DDT, effects                     298

    DDT, in treatment of jaundice      300

    Organochlorines, chronic
       poisoning                     358

    Chlorinated hydrocarbons          359
    DDT poisoning, symptoms         359

    Anticholinestenses, effects
       in humans                     411

 MALARIA
    DDT, use in control of             9

    DDT, use in control of             21

    DDT, use in control of             43

    DDT, persistence, use in
       control of                     49

    DDT. use in control of             91
    Dieldrin, use in                    91

    DDT, use in control of             104

    DDT, use in control of             296

    Baygon, use to control, effects     416

    DDT. use to control               472
MALLARD
   Residues in ducks                 171

   DDE, effect on reproduction in
      ducks                        209

   DDE. effects on reproduction in
      ducks                        212

MAMMARY
   Freons. piperonyl butoxide,
      carcinoma                     545

MANIA
   Organophosphates, behavioral
      changes                      410

MARINE
   Inhibition of algal
      photosynthesis, DDT           121

   Monitoring of pesticides in,
      organisms                     129

   Application of pesticide to
      prevent attack by               197

   Invertebrates, pesticides in          208

   Life, effects of pesticides on        210

   Environment, production
      of seafood                     220

MARROW
   Population studies                 255

   o,p'DDD, examination of
      bone marrow                   301
   Oral exposure to methoxychlor,
      humans                       301
   Biopsy of bone marrow             301

   Bone marrow, useful for in
      vivo testing                   589

MATERNAL
   Metabolism, offer i of oral
      intubation route              484

   Metabolism, oral intubation
      route                        487

   Methodologies for
      teratogenicity testing           659

   Use of techniques to measure
      body burden of
      suspected chemicals            663
156

-------
   Methods, statistical analysis

   Chlorinated hydrocarbons, DDT,
      DDE, transplacental
      passage of, study of
      spontaneous abortion

MATING
   Environmental control, insects

   Juvenile hormones, effects

   Dominant lethal test, rodents

   Methods, teratogenicity testing

MATURE
   Drug metabolizing enzyme
      system in animals

   Pollen abortion in flowers

   Cytogenetics, somatic cell
      genetics

MAYFLY
   2,4-D. effects on

MEAT
   Delaney clause, effect on

   Chlorinated hydrocarbon
      pesticide n.-sidues in
   Herbicides, residues in

   Residues in

   Accidental incorporation of
      pesticides in animal
      feed, residues in

   Pesticides in food and feed

   Residues in  humans,
      consumption of

   Pesticide residues from

   Pesticide residues from

MEIOSIS
   Atrazine, effect on
   Carbaryl, effect on

   DCNA, effect on
   Dicamba, effect on
   Endrin, effect on

   tsocil, effect on
SUBJECT
667


675

164

165
5%

667



426

578

587

126

14

136
136
138


159
170

320

385

537

639
639
640
640
640
£A 1
INDEX
Linuton, effect on
Monuron, effect on
Naptalam, effect on
Phosphamidon, effect on
Simazine, effect on
MELANOGASTER
Formaldehyde, effect on
Drosopbila
Maleic hyUrazide, effect on
Drosophila

MELLITUS
Diabetes, DDT exposure.
humans

MELON
Insect attractants, use to
control melon flies
Eradication programs for
melon flies
.MENTAL
Organophcsphatcs, effects
Behavioral toxicity,
definition
Anticholistrose compounds.
effects
FAA workers, exposure to
pesticides, effects
Phosdrin and/or Parathion
exposure, human, effects
Organophosphorus compounds.
effects
MESOTHEUOMA
Asbestos, complication of

METABOLISM
DDT. metabolitics, distribution
in environment
Needed support for research
Of heptachlor. heptachlor
epoxide
Fungicides and bactericides
Reeulators of plant growth

642
642
643
643
643


641

642



391



75

164

389

407

411

414

417

419

254



9
16

52
65
74
                                                                               157

-------
                            SUBJrCT INDEX
Of Zectran, by sunlight,
plants, animals
.
Of pesticides by plants

Of Guthion, metabolites in
cow s milk

Products, detection of

Pesticides, effects in fish

Of steroids, effect on
reproduction

Research needs „

Toxicological complexities

Needed knowledge in

Of DDT
Of DDT, measurement of DDA

Of DDT, ODD

Of DDT

Of DDT

Of DDT, adipose levels
Of DDT, sex differences

Of DDT, levels, effect of
phenobarbital.
phenytoin on
Of parathion, paranilrophuiol
Organophosphorus compounds.
effects on genito-urinary
system
Of paratliion, paranitrophenol
Of DDT. humans
Of pesticides, skin, needed
information

Of pesticides
Sample skin matrix
Of Guthion

111

133


140

172

210


211

. 240

246

255

268
298

300

319

320

321
322



323
347

373
388
390

401

402
405
426
In newborn animals

Of DDT, storage of, metabolites

Dicldrin, interaction.
unsaturated fatty acids

Of DDT, DDA formation

Of parathion

Of hcptachlor, heptachlor
epoxide

Of chemicals, effect of dosage

Of cL.ylcarbamate (uret>.an)

Need for studies on drug
metabolism, different
species

Drug metabolizing enzymes
Chemicals, effect on

Pesticides, effect on

Enzymes, effect of chlordane on

Enzymes, effect of
hcxot rbitalon
Research needed, drug
metabolism, various species
Research needed, toxicity.
metabc'
-------
                                 SUBJECT INDEX
   Of chemicals, effect of other
      physical factors                534

   Of chemicals, effect on storage      536
   Residues, effects on               S39

   Enzyme induction                 540

   MDP compounds, effect on         541

   Oi 3,4-benzpyrene                 544

   Of MDP compounds               547

   Of MDP compounds               548

   Of MDP compounds               549

   Of piperonyl butoxMe, mammals    552

   Of tiopital, mammals              553

   Of MDP compounds               555

   Mutagenicity testing,
      Neuiospora                    573

   Mutagenicity testing.
      metabolic products             589

   Host-mediated assay               594

   Metabolic inhibitors,
      structure activity
      relationship                    604

   Of chemicals, tentogenicity         658

METAMORPHOSING
   Juvenile hormones, production
      of during                      165

   Organochlorine insecticides,
      effects                        208

METAPHASE
   Preparations, for testing            589

   Examination of ce!b during         593

METASTASIZE
   Malignant tumors                  466
   Animal tumors                    466

MICE
   DDT, pest control                 54
 Inorganic rodenticides             71

 Miscellaneous rodenticides          72

 Pests                            150

 Repellents, use                    200

 DDT, carcinogenic in               357

 Norbormide, effects in             426

 Ethyl fenthion, toxicity            429

 Parathior., toxicity, effect
   of mice                       432

 Testing procedures, animals         465

 DDT, carcinogenicily in mice        471

 Tumorigcnicity testing in •          473

 Tumorigenicity testing in           474

 Tumorigcnicity testing in           475

 Testing in                        481

 Testing in, carcinogenkity           483

 Persistence of DMBA in            484

 Piperonyl jutoxidc in              492

 Organic phosphates in              518

 Sesame oil, effects in               543

 Freons, effects in                  545

 Coumaphos, effects in              546

 Myristicin, metabolism in           548

 Inhibition of enzyme
   systems in                     554

 Host-mediated assay                594

 Specific locus test                  595

 Dominant lethal test               597

TEPA. METEPA, mutagenic
   threshold in                   598

Captaa, mutagenicity testing in      639
DDT, mutagenicity testing in       639
                                                                              159

-------

MH mutagenicity testing iir

Tumorigcnieity testing, species
Captan, folpct
Organophosphates, effects in
2.4,5-T. effects in
Testing for increase anomalies
Testing for increase anomalies
Testing for increase anomalies
MICROBIAL
Control of insect pests
Fungicides and bactericides

Soil moisture, effects

Insect pathogens
2,4-D; effects

2.4.5T; effects

Mutagenicity testing

Mutagenic activity in

MICROORGANISM
Definition of pesticide

Sofl moisture, effect on
degradation by

2,4-D; decomposition by
soil microorganisms
Degradation of 2,4-D. MCPA.
and2,4,5-Tbysofl
microorganisms

2,4,5-T application to soil,
effect on microorganisms

Nematocide, effects on
Mil microorganisms

Host mediated assay

MILK
DeUney clause, effects on
Heptachlor, residues in milk
Carbamates, excretion in
SUBJECT
642

6S9
664
665
666
670
671
672
60
65

144

163
203

204

572

595


44


144


203


203


204


205

594


14
53
64
\KDEX
Milky disease, biological
control

DDT residues in, cow's milk
Residues in cow's milk
Bromide residues in cow's milk
Milky disease
Food additive, hydrogen
peroxide, used for
preservation of
Human milk, PCB in
Organochlorines in
Pesticides in human mflk

Human milk, DDT-derhred
materials in
DDT ingestion, infants
DDT in, human, cows

DDT in, human milk

Human milk, residues in

Pesticides in human milk

MINAMATA
Disease, malformations induced
by

Mercurials
Disease, production of

MISCARRIAGE
Mutagenicity

MITES
Oils, use to control

Cotton crops, chlorinated
hydrocarbons, use to control

2,4-D; effect on

Insecticides and miticides

Beneficial insects
Fertilizers, spider mite:
Parathion, use to control


82

139
140
198
217

244
258
269
373


374
374
385

437

449

674



661

675
675


569


62


84

204

206

207
218
652
160

-------
   Phosphamidon, use to control


MTTIC1DES
   Insecticides and miticides

   Synthetic organic insecticides
      and miticides

   Insecticides and miticides

   Application (M) miticide

MITOSIS
   Mammalian methods

   Examination of cells

   Carbaryl. effect on
   Chloroform, effect on
   2,4-D, effect on

   DDT, effect on
   Dieldrin. effect on

   Lindane, effect on

   Maleic hydrazide, effect on

   Paradichlorobenzene, effect on
   Parathion, effect on


MOISTURE
   Factors influencing changing
      use patterns

   Factors, soil contamination

   SoO moisture and temperature

   Wind erosion

   Bacteria, resistance to

   Persistence of 2,4-D

   Nematocides and so!l fumigants

MOLLUSCICIDE
   Invertebrate poisons, used to
      control moJhisc*
   Toxicity to fish
   Toxicity to warm-blooded
      animals

   Pentachlorophenol. used to
      control molluscs
SUBJECT
653
61
63
206
645
587
593
639
639
639
640
640
641
642
643
643
58
143
144
145
163
203
205
72
72
72
6S2
INDEX
MONGOOSE
Biological control,
introduction to control tats
Use for rat control
MONKEYS
DDT administration to
DDT excretion
DDT residues in
DDT in body fat vs diet
DDT in bodyfat vs
continuous exposure
DDT in bodyfat after exposure
terminated
DDT. DDA in vs daily dose
Endrin in, effects
Metabolism of DDT. DDE
Metabolism of pesticides in
DDT storage
Sarin toxicity, effect of
temperature
DDT, liver effects
Sarin toxicity, effect of
temperature
Piperonyl butoxide toxicity
Captan. tentogenic studies
MORBIDITY
Pesticide related
Studiss
Epidemiologic studies
Pesticides, diseases
Epidemiological approach.
human effects
Tata extrapolation
Studies, case reports
 82

216

 264

 268

 272

 277


 282


 286

 289

410

424

427

423


432

435


533

542

664


237

251

252

253


295

307

344
                                                                               161

-------
                                  SUBJECT INDEX
    Effects of occupational
       exposure                      345

    Specific conditions, blood
       dyscrasias                     388

    General measures of               390


 MOTHPROOFING
   Exposure, humans                  ISO
    Wearing of clothing treated
       with pesticides                 ISO
    Study of dry-cleaning firms         ISO
    Chemicals used                    ISO
    Exposure to DDT                  ISO

 MUCOSA
    Organophosphorus compounds,
       effect on intestinal mucovj       361

    Nitrogen-containing pesticides       370
    Paraquat ingestion. effects          370

 MUSCULAR
    Inorganic arsenical:, muscular
       cramping, symptoms of
       poisoning                      362

    Anticholinesterases,
       administration, humans         411
    Muscular aches and pains           411
    Organophosphorus agent           411
    Low doses, effects                411

    Metaisosyctox, symptoms of
       poisoning                     414

    Organophosphorus compounds,
       effects                        416
 MUTAGENS
    Chemicals proposed for insect
       sterilization                    83

    Chemosterilants                  164

    Research studies needed,
       animals, mutagcnesis           241

    Alkylating agents                 261

    Captan. effects in bacteria          438

    Interactions                      515

    Mutagenicity of pesticides          567
 Mutagenicity as public
   health hazard                 568

 Ejects                          570

 Information needed on
   mutagenicity                  571

 Methodologies for mutagenicity
   testing                       572

 Bacterial                        572

 Neurospora, mutations in          573

 Phage and transformation          574

 Plants, mutations in               575

 Mutation induction by seed
   treatment                     576

 Root tip method for
   chromosome aberrations        577
 Somatic mutation methods         577

 Specific-locus method (waxy
   locus) in poDen                578

 Summary, methods used for
   detecting                     582

 Mutations, chemicals producing     583

 Mutations, chemicals producing    . 584
 Mutations in barley               584

 Mutations, chemicals producing     585
 Drosophila, mutations in           585

 Cytogenctics and somatic ceQ
   genetics                      587

 Chemicals producing              591

 Host-mediated assay               594

 Specific ltx.-us test                 595
Potent mutagenic compounds       595

 Dominant lethal test               596

Population monitoring             599

Summary, mutations'              601

Recommended program for
   testing                        602
162

-------
   Smicture-tctivhy-relations

   Aticylating agents, effects

   Mercurials, effects

   Testing

 MYOCARDITIS
   Organophosphonis compounds,
      acute toxic myocarditis

 Paraquat ingestion, myocarditis

 NAILS
   Paraquat, diquat, effects on

   Paraquat, diquat, effects on
   Needed observations on, as
      index of toxicity
   Sample skin matrix

 NARCISSUS
   2.4-D. effect on

   Ethylmercury chloride, use
      to treat bulbs

 NARCOLEPTIC
   Sleep patterns

NASAL
   Allergy, pesticide exposure

   DDT. effect on nasal vibrissae

   Congestion

   Perforation of nasal septum
      chronic arsenical poisoning

   Irritation from
   2-chlorophenylphenate and
      sodium orthophenyl phenate
      /
NAUSEA
   Organochlorines, effects

   Organophosphates, effects

   Organophosphates

   Arsenical poisoning

   Yellow phosphorus
SUBJECT
604

606

608

639


371

371

365
405
405
405

639


649

416

148
296
361

363

370
370

301

358

360

361

362

371
INDEX
Chlorinated hydrocarbons,
effects

Poisoning symptoms

Cholinesterasc inhibitors.
effect*
NECK
Chlorinated acid derivatives,
2.4-D; 2,4,5-T occupational
exposure, hyperpigmentation
Organophosphorus compounds.
precautions
NECROSIS
Paraquat, over effects
DDT. lim effects
DDT. livir effects
NEMATOCIOE
Halogens :ed hydrocarbons
Organic phosphates
Oyanates
Thiophenes
Volatile liquids, gases

And soil famiganls
Chlorinated aliphatics, effects
Chlorinated aliphatics
Mode of action
Application form(N)

NEMATODE
Biological control
Nematocides
Kalogeiu*ed hydrocarbons.
effects
Organic phosphates, effects
Cyanates, effects
Thiophenes, effects

Insect pats, predators

Insect pathogens

Volatile liquids, gases,
control of


446

449


450



365

444

373
434
435

71
71
71
71
198

205
367
369
604
645


60
70

71
71
71
71

162

163


198
                                                                             163

-------
   Barriers, application of

   Pathogens

   Water management, effect on

NEONATAL
   Toxicity testing and
      carcinogeniciiy testing
      using

   Non-human primates,
      teratogenicity testing

   Body burden, need for study

NEOPLASM
   Lindane, effects, comparison
      with other populations

   Storage of DDT, DDE in humans

   Tumors, as end points of study
   Testing of chemicals for
      benign, malignant neoplasms

NERVE
   Pyrcthrin, allethrin.
      effects on

   Chlorinated hydrocarbons,
      effect on

   Isopestox. effect on

   Organophosphates, effect on

   DDT, effect on

   Classified oiganophosphorus
      agent, effect on

   Organophosphates, effect on

   Otolinesterase agents, effects

NEURITIS
   Chronic arsenical poisoning,
      signs and symptoms of

   Thallotoxicosii, signs.
      symptoms

   Chlorinated phenols, effects

   Metallic derivatives
   Organic mercurial pesticides.
      effects
SUBJECT
199

216

213



485

661

V663

372

430

482

482

63


359

360

369
408


411

419

452


362

363

367

368

368

INDEX
2,4-D, production of
peripheral neuritis

Mipafox, production of
peripheral neuritis
NEUROLOGIC
Experimental respiratory
exposure to DDT

DDT, exposure, humans
Occupational exposure.
pesticides
Thallotoxicosis, symptoms
Abnormalities

DDT exposure, humans
i
'•Occupational exposure

Chlorinated hydrocarbons,
effects
Pesticide, effects
NEUROMUSCULAR
Parathion effect on
ncuromuscular system
Organophosphates, effect on
nervous system

Organophosphorus compounds
Effects on respiration
DDT, effects on ncuromuscular
system
Chlorinated hydrocarbons.
effecb on ncuromuscular
system

Attopine, effect on NMJ

EPN, malathion, effects on NMJ
Structure-activity
relationships
Inhibitors of NMJ
NEUROPATHY
Hazards from exposure

Mipafox, peripheral neuropathy

Chlorinated phcnoxy acid
compounds
2,4-D, peripheral neuropathy


406


416


296

299

351
363
389

391

394


408
413


206

206

369
369

425


425

452

523

604
604

261

360


362
362
164

-------
                                 SUBJECT INDEX
NEUROSPORA
   Crassa, metabolism, different
      from mammals                 573

   Testing for mutations in            S8S

   Use in tests                       594

   Fumigants, mu tations in            611

   Ethylene chlorohydrin,
      mutations in                   611
   Organophosphate insecticides,
      mutations in                   611

   Ethylene oxide, mutations in        640

NEUROTOXIC
   Parathion. malathion, isopestox      360

   Pathology, exposure to
      pesticides                      433

NONCARC1NOGENIC
   Substitutes for agents              478

NONTOXIC
   Phthalic acid herbicides,
      effect on mammals              68

   Botanical rodenticides,
      effects  on other
      warm-blooded animals           72
   Miscellaneous rodenticides          72
   Norbormide, effects on other
      warmblooded animals           72
   Molluscicides, effects on fish,
      effects  on warm blooded
      animals                       72

   Plant growth regulators, effects
      on humans, other warm-blooded
      animals                       73

   Repellents, effects of               215

NOSE
   Respiratory exposure to DDT,
      humans, experimental           296

   Carbamates and dithiocarbamates,
      irritation of nose                369

   Areas of exposure                  407

   Cholinesterase inhibitors,
      effects  on                      446
NOSEBLEED
   Gentian violet, effects             368

   2-chlorophenylphcnate and
      scdium orthophcnylphenate,
      effects                       370

NURSERY
   Orga,iochlorines, uses              55

   Nitrite herbicides, uses              70

   Estuarinc areas, marine food
      production                    121

   Pentachlorophcnol, linens          311

NUTRITION
   Fertilizers, host plant, effects       218

   Research needs, states, effects
      on pesticide responses          240

   Infants, DDT ingestion             374

   Effect on DDT residues            388

   FacUxs affecting responses         426

   Effcc. on pesticides               431

   Effect on storage                  530

   Diet, effect on toxicity             532

NUTS
   Fumigants containing bromine,
      residue entering crops          198

   Piperonyl butoxide, uses           542

   Acrytonitrile, uses      '          645

   Ferbam, uses                     649

   Simazine, uses                    653

NYSTAGMUS
   Organophosphorus compounds,
      chronic exposure of pilots to     414

OAK
   Poison oak, contact dermatitis      398

OATS
   Losses due to insects                86
                                                                              165

-------
                                 SUBJECT INDEX
    Heptachlor and heptachlor
      epoxide, residues in
    Aldiin and dielctiin, residues in

    Resistant strains of plants

    Propham, uses

 OBESITY
    Occupational exposure to
      pesticides, effects

    2,4-dimtrophenoI, use to
      treat
    Cataracts from 2,4-dinitrophenol

 OCCUPATIONAL
    Lindane, exposure vs home
      exposure

    Exposure, pesticides,
      accidents

    Exposure, accidents, pesticides

    Exposure, accidents

    Exposure, humans

    Exposure, pesticides

    Exposure, needed surveillance.
      clinical testing

    Exposure, studies of

    Exposure, studies of

    Exposure, diseases

    Exposure, diseases

    Exposure, general population
      studies

    Exposure, case reports
    Exposure, studies of groups

    Exposure

    Exposure, routes of entry

    Exposure, dktdrin

    Exposure, adults

    Exposure, reporting of
Exposure, epidemiology of
133
133

162
653

351

368
368


149

152
157
158
172
234

242

251

252

253

254

255
256
256
260
263
302
306
307
pesticide poisoning

Exposure, epidimiological
studies
Exposure, DDT residues
Exposure
Exposure, mortality studies
Exposure, morbidity effects
Exposure, carbamates

Exposure, diene group
Exposure, chlorinated
hydrocarbons
Exposure, phenoxy chemicals
Exposure, effects
Exposure
Exposure, skin effects
Exposure, dermatitis
Exposure, dermatitis, captan
Exposure, skin conditions

Exposure, chlorinated
hydrocarbons, effect on
cardiovascular system

Exposure

Exposure

Exposure, DDT
Exposure
Exposure, hazards of current
pesticide use
Exposure, DDT
Exposure
Exposure, needed studies
Health specialists, survey
Exposure, poisonings, effects
314


319
324
327
344
345
348

349

3:0
350
351
356
363
364
365
366



370

383

385

386
389

392
393
394
395
415
416
166

-------
                                 SUBJECT INDEX
   Exposure, poisoning, relationship
      to, acute dermal LD-50          423

   Exposure, effects

   Exposure, DDT

   Exposure, surveillance of

   Exposure, evaluation of
      carcinogenic hazards

   Exposure, legislative needs

   Exposure

   Exposure, interactions

   Exposure, cholinestcrasc
      inhibition

   Exposure, chlorinated
      hydrocarbons

   Exposure, interactions

   Exposure

   Exposure. DDT

OCEANS
   DDT in

   DDT contamination of

   Pesticides in, need for data

   Pesticides in

   Need to study pesticides in

   Pesticides in surface waters

CDOR
   Chlordanc, low odor, properties     151

   DDT, solutions of

   Intolerance of pesticides

   Psychogenic odor

ODORLLSS
   Anticoagulant rodcnticidcs,
      properties
   Fluorine rodcnticidcs.
      properties

   Suspensions of DDT, properties     298
   Lindane, crystals, properties        650
OIL
442
447
454

464
480
496
509

514

521

526

527

538


9

13

23

101

169
171

151

298
415
418


72
72

298

Use before 1945
Insecticides, uses
Of poison ivy, effects
Seeds, use of BHC, chlorinated
hydrocarbons
Mosquito control
Dietary intake, residues in
Toxaph-:ne, stiobane in,
spraying of cows
Cod livsr oil, analysis
DDT in olive oil, effects

DDT in, effects

Fats, effect on DDT toxicity

Sesame, use in cancer research

Application form (OS) oil
solution

Phosphamidon, colorless oil

OLIGURIA
Poisoning, effects, chlorinated
hydrocarbons

OLIVE
Chlorinated hydrocarbons, uses
Scale insect
DDT, in olive oil, effects

ORGANOMERCURIAL
Poisoning by
Economic poisons, chemical bums
Compounds, testing for
teratogenicity
OSPREY
Population declines in
OVA
Residues of pesticides in
salmon

45
62
83
•
90
127
136

140
257
297

298

431

543


645

653



373


84
216
297


442
443

664

211


129
167

-------
                                SUBJECT INDEX
 OVARIECTOM1ZED
    pjp'-DDT, nonestrogenic activity

 OVERDOSAGE
    Spraying

    Application of water soluble
       materials

    Toxaphene, effect on lake

 OVEREXPOSURE
    Limits of pesticides in blood
       to prevent

    Limits of pesticides in
       blood to prevent

    Abnormalities in EEC,
       dienc group

    Acute toxicity

    Personal indicators of

 OVULATION
    Effects of insecticide on birds

    Testing in animals
 OWLS
    Effect of pesticides in

 OXIDASES
    Microsomal enzymes

    MDP compounds, effect on

    Effect on MDP compounds

    Metabolism of MDP compounds by  554

    Metabolism of MDP compounds by  559

    Effect of chemicals on

OXIDATION
   Removal of 2,4-D from water

   Nirrophenols, effect on
      metabolism

   Ethylene thiourea, product of
      Nabam

   Drag metabolizing enzymes,
      effect of chemicals on

437

107

198

213


35

234

349
382

446

211
661





516

541

548
554

559

560


123'


433

492

517
Of MDP compounds

Of MDP compounds
Reactions
Reactions of chemicals

Oxidative phosphorylation.
inhibitor) of
OXIMES
Tcmik, effect in human

Carbamoyl oximes, effects

Antidotes in animals, humans
Antidotes
OYSTERS
Polystream, use to control
snails in oyster beds
Cumulation of chlorinated
hydrocarbons
Pesticides in
Chlorinittd hydrocarbons in
Pesticides in

Pesticides in, use as
indicators

• Pesticides in, use as monitors

PACKAGING
Need improvements in
Need for more suitable
materials used in

Materials

Need for more suitable
materials used in

Materials, prevention of
accidents

Materials
Materials, accidents
Materials, design, prevention
of accidents •
548

549
554
555


640

362

367

426
453


72

118
121
129
171


185

208


18

24

77


103


159

192
193

356
168

-------
    Materials, use of Dowcide-7 on

 PAIN
    DDT, effect on sensation of

    2,4-D; epigastric effects

    Oiganophosphates, effects

    Organophosphates, eye
       contamination, effects

    inorganic a-ienicals, acute
       effects

    Yellow phosphorus ingestion,
       effects

    Anticholincstcrascs. effects

    Economic poisons, effects

 PAINT
    Incorporation of pesticide^ into

    Use of pesticides in

    Dermatitis from mixture of
       paint cleaner and
       pcntachlorophcnol

 PALATE
    Carbaryl. case of cleft palate

    Production of cleft pilate

 PAISY
    Mercurials, infantile
       cerebral palsy
    Fish and shellfish contaminated
       with methybnercury


 PANCREAS
    Carcinomas of, pesticide
       concentrations in, humans

    Cancer of

 PANTS
    Epidemics of poisonings,
       mevinphos

    Pesticide spilled on

PAPILLOMA
   Gastric papillomas, incidence of
SUBJECT
475


297

350

360


361

362

371
411

449


146

197



364


664

665


675
675


495

497



310
tot
383

486
INDEX
PARALYSIS
Motor, chronic arsenical
poisoning

Organophosphates, effects

TEPP, effects

Organophosphates, chronic
* exposure, FAA. workers

Organophosphates. effects
Orpine-phosphates, triorthocresyl
phosphates, effects
Oxures, a.itidotcs
Zoxazolai-iinc, effects of
prpercnyl butoxide on
PARASYMPATHETIC
Organophosphonis compounds.
stimulation of
para-sympathetic nervous
system

Organic phosphate pesticides.
effects OR parasyrnpathctic
nervous system

PARENTERAL
LD-50 studies

Administration, enzyme
induction
Administration, induction of
dominant lethal mutations
Administration, TEPA, METCPA,
effects, mice
Administration, testing for
teratrgenicity
PARESTHESIA
Acute DOT poisoning, effects

Occupational exposure.
organophosphorus
insecticides, effects
PAROTID
lietak. concentration in
saliva
r-UlSNlP
Linuron, uses



363

369

406


414

416

424
453

546




369



425


402


519

596

598

660

359



414


448

650
                                                                                169

-------
                                 SUBJECT INDEX
 PEACH
    Paradichlorobenzene. i-scs

 PEANUT
    Residues of pesticides in

    Bromide residues in hay
    Fumigants containing bromine

    Effects of fats on DDT toxicity

    Ethylmercury chloride, uses

    Naptalam, uses


 PEAR
    Biological control of
       prickly pear cactus

    Spraying of dieldrin, orchards
    Exposure of humans

 PEAS
    Lindane, uses

 PELICAN
    Toxaphene, mortalities in
       fish-eating birds

 PEPTIC
    Ulcer, pesticide exposure,
       population study, exposure to
       aldiin, dieldrin

 PERCEPTION
    Organophosphonis compounds,
       effect on depth perception

    Organophosphonis compounds,
       effect on light, depth
       perception

    Pesticides, effects on depth
       perception
    Occupational exposure, effects
    TEPP, effects on depth
       perception

 PERCUTANEOUS
    Absorption, route of entry

    Absorption

    Absorption, washing of skin
       tc reduce

    Penetration
Penetration, parathion,
051

133

198
198
431

649

651


82

155
155

650


211


351



361

367

406
406

406

263

264

400

401
paraoxon
Effect of vehicles on

Sample skin matrix

Temperature, effect on
PERINATAL
Chlorinated hydrocarbons.
residues in human milk.
not related to perinatal
toxicity
PERITONEAL
Injection, host-mediated assay

PERMISSIBLE
Limit, mcthoxychor
Levels
Levels, enzyme induction
PERS'STENT
Residues of, in air, soil,
water
Use of, need for review
Pesticides, residues

Chemicals, provide incentives
to industry to develop
specific, less-persistent
chemicals
Chemicals, use of
Pesticides, decline in use
since 1957
Pesticides, need to replace

Need for development of
less-persistent pesticides
Pesticides, exposure to

Pesticides, salts of heavy
metals
Insecticide use patterns

DDT. use in malarial
eradication
402
403

405

432




674

594


301
495
519


9
10
12




17
19

21
23


24
35


45
48


49
170

-------
                               SUBJECT INDEX
Restrictions in use of,
   methoxychlor usage              51

Use of, in pest control
   industry                        53

Use in insect contiol                54

Use of, insecticides                  55

Pesticides, residue problem,
   new pesticides                   59

Organochlorincs, chlorinated
   hydrocarbons                    63

Phenoxy herbicides, soil             68
Phenylacetic acid, soil               68
Bcnzoic acid compounds, scQ        68

Phthalic acid compounds, soil        68

Substituted phenol herbicides,
   soil                             69
Heterocyclic nitrogen
   derivatives, soil                  69
Substituted ureas, soil               69

Carbamates, soil                    70
Other amides, soil                  70
DinitroanUinc herbicides, soil        70
Nitrite herbicides, soil               70

Plant growth regulators              73

Interest in                          79

Toxicity to humans                 102

Pesticides                          103

Gradations of, chemicals            104

Of pesticides in air                  105

Of pesticides in atmosphere.
   effect of formulation, size        108

Of pesticides in air                  114

Of pesticides in air                  US

Pesticides in marine environment     121

Water quality                       122

Endrin, in water, fish, plants         125
Metabolism of pesticides by
   plants                         133

Chlorinated hydrocarbons           136

Guthion, on fruit                  142

Pesticide type and formulation       143

Use of DDVP with Diazinon,
   chlordane                      151

Commercial pest control            152

Pesticides, DDT, occupational
   exposure, residues in adipose
   tissue                          153

Development of nonpersistent
   pesticides                      161

Chlorinated hydrocarbons, use
   reduced over next 2 yeurs        180

Effects on biological systems        187

Tree preservation, use of DDT       196

2.4-D. in soil                       203

Herbicides                         204

Plant growth regulators              205
Arsenic acid, sodium arsenitc        205

Pesticides, effect on
   nontarget organisms             206

Insecticides, effect on
   nontargct fish                   210
DDT.cflecUinfish                 210

Chlorinated hydrocarbons           211

Chlorinated hydrocarbons,
   effects                         212

Toxaphenc, effects on
   aquatic fauna                   213

Pesticides, exposure to              234

New pesticides                     238

Action to improve protection
   of public health                 239
Discourage home use of
   persistent pesticides             239
                                                                               171

-------
                                  SUBJECT INL'EX
    Of pesticides

    Role of dietary sources of
       pesticides

    Exposure to pesticides

    Thallotoxicosis, neurological
       damage

    Effects, pesticide exposure

    Pesticides, DDT

    Pesticides, interactions,
       tissue storage

    Pesticides, needed information
       on enzyme induction

    Pesticides, need for
       mutagcnicity testing

    Fumigants. effects on humans

 PHARYNGITIS
    Paraquat ingcstion

 PHEASANT
    DDT, egg shell thinning in
       ducks, not pheasants

    DDT. egg shell thinning in
       ducks, not pheasants

    Deaths in, from seed dressings
       containing pesticides

 PHEROMONES
    Potential uses of

    Advantages, disadvantages of

    Sex phcromones. uses
    Developmental phcromones

 PHOTOLYSIS
    Exposure of pest:cul« to air

 PHOTOSYNTHESIS
    Pesticides, effect on

    DDT, effect on marine algal

    Pesticides, effect on

    Solar energy, use in
248        DDT, effects on

           Structure-activity-relations,
207
326
357

363
415
472

525

530

603

611

373


25


179

200


61
81
219
219

114

25

121

179
186
inhibition of
PHYTC'rt-ANKTON
Production of oxygen by
DDT, effects on
Pioduction of oxygen by
Ncodcd observations on
Effects of pesticides on
Need for investigation of
effects of pesticides on
PHYTOTOXIC
Fungicides, problems of
Cereals
Aldrin, dieldrin as seed
dressings without
phytotoxicity
Volatile liquids, less
•* phytotoxic
Residues in soil, effects

PIGEON
Avicidcs, use to control
\vitrol, use to control
Consideration of pest probl-m

PICS
Guinea, isco to collect fleas
in buildings
Oui.-vM, allergic sensitization
Guinea, metabolism of Guthfon

DDT storage in, sex difference*
Guinea, ethyl fenthion toxicfty
in, sex differences
Guinea, malcic hydrazide.
mutagenicity testing

PINEAPPLE
Auxins, uses
Monuron, uses
604

28
121
182
205
207

207

66
85


85

198
214


73
7?
214



83
399
426

428

429

642


74
651
172

-------
                                 SUBJECT INDEX
 PISC1C1DE
    Use of

 PLACENTAL
    Transfer of dieldrin and
       incidence of stillbirths,
       cows

    DDT, DDE, passage of through

 PLAGUE
    Use of BHC, dieldrin

    Materials used for control of

    DDT, control of vectors, of

 PLASMA
    Cholinesterase levels

    Parathion exposure

    DDT, effect on bilirubin levels •

    Dieldrin exposure, humans

    DDT levels, humans

    Dieldrin exposure, humans

    Baygon, effect on cholinesterase
    DDT levels, rats

    DDT in. human

    Aliesterascs

    AUesterascs, needed studies

    Glucocorticosteroid level,
      effect on

PLASTIC
    Polychloiinated biphenyls,
      use in
    Storage of samples in plastic
      containers, source of error
      in analysis

PLUMS
    Fate of malathion residues on

PNEUMONIA
   Intoxicatioi by economic
      poisons, effects
       POISONINGS
73        Need for regulations, collection
             and disposal of pesticides,


665

674

90

214

296


260

296

300

301

329
349
361
431
449

510

S13

533

257

257

141

449
containers
Dieldrin, endrin

Poisonous, Compound 1080
(sodium monofluorcacetate)
New methods of application

Stomach poisons
Contact poisons
Fumigant poisons

Pyrcthrin, allcthrin, nerve
poison, insects

Organophosphatcs, exposure to

Contact, stomach, carbamatcs

Nematocides

Strychnine baits
Invertebrates, molluscicides
Thallium sulfate
Attractants, incorporation
into poison baits
Toxicity scheme, need for
education of consumers

Parathion, humans

TEPP, humans, livestock
ODD, fish, birds
Household use of pesticides
Occupational exposure
Parathion

Parathion
Accidents
Accidents
Nerve poison, DDT. DDE, ODD
18
34


45
60

61
61
61


63

64

65

70

72
72
73

75

77

81

83
127
145
153
155

156
157
158
189
                                                                             173

-------
     Arsenic

     Birds, DDT

     Avicides

     Organochlorine

     Acute, organophosphates in
       bulk food, water sources

     Pesticide protection teams,
       investigation, reporting

     Occupational exposure

     Acute

     Acute, animal, vs human

     In homes

     Experimental oral exposure
       to DDT, humans

     Acute, epidemiology of

     Humans

     Occupational

     Children, adults

     Epidemics of, by pesticides

     Epidemics of, by pesticides

     Pesticides, humans

     Acute

     Occupational, acute,
       organophosphates

     Carbamate

     Organophosphates

     Clinical case reports

     DDT, acute, effects on the
       nervous system

    Organophosphates, symptoms

     Baygon, humans
SUBJECT
206

211

214

233

234

241
250
251
259
263

297
305

306
307

308

310

311
314
319

347

348

356

358

359
360
361
INDEX
Organic mercurials
Inorganic arsenical*

Thallium

Thallium sulfate, chronic,
effects
Effect* on the eye

Diazinon, effects
Organophosphorus compounds
Paraquat, effects
Yellow phosphorus ingcstion
Chlorinated hydrocarbons, humans
Chlorinated hydrocarbons, humans
Organophosphatcs, humans
Systemic
Organophosphatcs, neurologic
abnormalities
Acute, humans
Behavioral effects of
pesticides

Acute, chronic

Chlorinated insecticides, acute.
effect on nervous system
Organorihosphatc
Organophosphale
Occupational exposure

Organophosphate

Phosdrin and/or Parathkm

Acute, organophosphates,
behavioral changes
Fatal, human, animal
experiments
DDT. animals, effects
Norbormidc, effect in rats

362
362

363


365
366

367
369
370
371
372
373
373
383

389
434

406

407


408
412
414
415

416

417


418

424
425
426
174

-------
                                 SUBJECT INDEX
Parathion. humans
Organophosphates, sex
differences

Diseases, effect on
DDT, humans
428
429

430
430
Of estuaries
Of sir, water
Environmental

Soil
   Nutrition, effect on                431

   Organophosphates, effect of
      temperature on                 433

   Chlorinated hydrocarbons, rats      435

   Chlorinated hydrocarbons in rrulk    437

   Humans, reported by Poison
      Control Centers                 442

   Economic poisons, effects           443

   Personal protective equipment       444

   Airplane pilots                    445

   Characteristics of                  446

   Diagnosis of                      447

   Parathion, use of
      p-nitrophenol as indicator
      in treatment of                 448

   Cholinesterasc inhibitors            449
   Pesticides, symptoms               449
   Diagnosis, hypersensitivity          449

   Atropine. use in                   450

   Chemicals, use to treat             451

   Atropine, UK in                   452

   Organophosphorus compounds      453

   Useofatropine,
      tetraethylammonium chloride    454

   Atropine, use in                   534

POLLUTION
   Early warning system, use of        31

   Air, interest in                    79

   Of ground waters                  H6

   Of water by pesticides              118
   Of environment

   Environmental

   In aquatic environment

   Hazard, pesticides

   Environmental

   Environmental

   Air pollutants, interaction
      with pesticides

   Air pollutants, interaction
      with piperonyl butoxide

   Environmental pollutants,
      effect on piperonyl butoxide

   Water pollutants, tested for
      mutagenicity, mice

POLYMORPHONUCLEAR
   Lindane, effects   ,

POLYNEURITIS
   Mipafox, production of

   Organophosphates occupational
      exposure, effects

   Aldrin, dieldrin, suspected
      human cases of


PONDS
   DDT, applied to, concentration
      in water
   Contamination by endrin

   Parathion in

   Transport of chemicals in
PORPKYRIA
   Occupational exposure to
      phenoxy herbicides (2.4-D;
      2.4,5-T). effects
                                    121

                                    192

                                    193

                                    195

                                    196

                                    197

                                    202

                                    215

                                    220

                                   409


                                   525


                                   541


                                   546


                                    598


                                    350


                                    413


                                    414


                                   417
                                   120
                                   120

                                   144

                                   187
                                   350


                                   175

-------
                                  SUBJECT INDEX
     Hexachlorobenzcne,
        contamination of grain,
        effects in humans

     Hexachlorobenzcne,
        contamination of grain,
        effects on humans

     Hexachlorophenc-induced,
        rats, photosensitivity in

     Structurc-activity-rclations
     Mode of action; inhibitor
        of porphy rin

 POSTEMERGENCE
     Heterocyclic nitrogen
        derivatives
     Postemcrgence activity

     Herbicide, paraquat, diquat

     Herbicides; 2,4-D; 2.4,5-T

 POTABLE
     Water supply
     Standards, limits

 POTATO
    Paris Green, use against beetle

    Organochlorincs, uses

    Growth rctardants, uses

    Total insecticide usage,
       chlorinated hydrocarbon usage

    Crops, including sweet potatoes

    Chlorinated hydrocarbon residues

    DDT residues in

    Aldrin, trandocation in

    Endrin, occupational exposure

    Resistant plants

    Sodium anenitc, use as
       potato vine killer

    Linurcu, use on

    hhptalam, use on
    Maletc hydrazide, use on
POTENT1ATOR

364


372

433

604
604

69
69

205

610

121
121

45

55

74

84

87
136
141
144
155

162

205
650
651
651
Drugs, potentiate poisoning

Of malathion toxicity
Of malathion toxicity

POULTRY
Mongoose, effect on
Chlorinated hydrocarbons.
dietary residues
Raisers, use of pesticides
Seed treatment, hazards to
Mongoose, effect on

Pesticides, residues in

Pesticides, residues in

Caibaryl, uses
PREEMERGENCE
Phthalic acid herbicides
Phthalamic acid compounds

Substituted phenol herbicides
Heterocyclic nitrogen
derivative herbicides
Substituted ureas
Carbamates
Other amides
Dinitroanilinc herbicides
Nitrite herbicides
Herbicides
Chlorpropham, herbicide
Naptalam, herbicide
PREGNANCY
Losses, need for increased
Federal support of research
Information needed.
interpretation
Dominant lethal assay
Methodologies for
teratogenicity testing
418

512
513


82

136
1%
200
216

385

537

646

68
68

69

69
69
69
70
70
70
610
646
651


16

260
597

658
176

-------
SUBJECT 1NJ >EX
Thalidomidc, effects in humans

Testing of compounds, animals
Animals during, handling of
PCNB administration, mice

Methods of testing

Chlorinated hydrocarbons in.
humans
Mercurials, consumption of fish '
by Japanese, effects in

PREHARVEST
Auxins
Uses
Arscric acid, use as dcssicant

PREIMPLANTATION
Dominant lethal mutation
measurements

Losses
ISFNATAL
Teratology

PRETREATMENT
Organochlorincs
DDT

Organophosphatcs
Of cells

PROTHROMBIN
Pesticide usage, effects on

Anticoagulant rodenticides,
effects
PROTOZOA
History of pesticides
Alternate control techniques
Insect pathogens
Pathogens
PSYCHIATRIC
Symptoms. DDT ingestion
Drue literature
659

660
661
666

667


674

675


74
74
205



597

598

657


55
120

518
593


351

451

44
60
163
216

391
408
Symptoms, organophosphatcs
DFP exposure, humans

Oiganophosphate poisoning,
effects
PSYCHOGENIC
Odor

Odor, pesticides

PSYCHOLOGIC
Organophosphate, effects
Evaluations in children,
poisoning cases

PSYCIfONEUROSIS
Of non-pesticide origin

PSYCHOSIS
Miscellaneous pesticides,
ingestion, effects

Behavioral changes
Of non-pesticide origin
Reactivation by DFP
Pesticides, not established
as causing
PSYCHOTIC
Symptoms, pesticide exposure
Symptoms, reactivated by DFP
Organophosphate poisonings.
effects
PULSE
Chlorpromazinc, effect on

PUPAE
Insecticides, control of
Sterilization of
PUPS
Group size
PYREXIA
Organophosphates, exposure
of pilots to, effects
PYROLYSIS
Disposal methods

QUAIL
DDT, no production of egg
shell thinning in
413
413

416

415

419


411

417


418



371

413
418
418

419

413
413

415

418


53
83

484

414
159


25
                                      177

-------
                                 SUBJECT INDEX
   DDT, no production of egg shell
      thinning in

   Heptachlor, effect on quail
      population

   Estrogenic activity of
      oj> '-DDT in

RABBITS
   Botanical rodenticides,
      effect on

   Fate of cyclodienes in

   ADcrgic sensitization

   Parathion, paraoxon dermal
      absorption in

   DDT poisoning in. effect of
      liver damage

   Metabolism of MDP compounds
   Rperonal excretion in

   Teratogenicity testing, use of
      lower mammalian species

   Cap tan, teratogenic in

RACCOON
   Chemical control measures for

RADISHES
   Aldrin, trandocation of
      from soil

RAGWEED
   Pest problem

RAIN
   Pesticides, precipitation from
   Pesticides in air. decrease
      levels after

   Pesticides in

   Endrin in runoff water

   Effect on Guthkm residues

   Leaching of pesticides from
      soU by

   Diddrin in runoff water
                                    179


                                    211


                                    665



                                    72

                                    268

                                    399


                                    402


                                    430

                                    547
                                    S47


                                    659

                                    664


                                    71
                                     58
                                    "4

                                    H*

                                    125

                                    142


                                    144
   Resistant crops, effects of
      rainfall on                    161

   Effect on granule formulations
      of pesticides                  200

RATS
   Pesticides before 1945             44
   Red squill, use                   44

   Red squill, use. supply             45

   Inorganic rodenticides             71

   Botanical rodenticides             72
   Red squill, use                   72
   Miscellaneous rodenticides         72
   ANTU, use                      72
   Raticate, use                     72

   Mongoose, use to control          82

   Pests, controlled by pest
      control operators              150

   Endrin contaminated bread,
      effect on                     158

   o,p ;-DDT, effect in               213

   Mongoose, use to control          216

   DDT in                         264

   HEOD in                        265

   HEOD in                        266

   HEOD in                        267

   HEOD in                        268

   DDT in                          269

   HEOD in. model                 272

   DDT storage in, vs concentration
      in diet                       275

   HEOD in. vs daily intake           279

   DDT in, concentration in diet       281

   HEOD in, concentration in diet     284

   HEOD in bodyfatvs blood         285

   DDT in. during post-exposure       287
178

-------
                               SUBJECT INDEX
HEOD in adipose, during
   post-exposure

HEOD in blood, liver, during
   post-exposure

Yellow phosphorus, use

DDT, effect on locomotion

Carbaryl, Baygon, effect on
   self-protective responses

Parathion. effects in

DMSO, effect on spontaneous
   motor activity

Metabolism of DDT to DDE

Nofbofinide, use


EPN. ethyl fenthion, toxicity
Malathion, DDT, dieldrin.
   toxicity
Cholinesterase insecticides,
   toxicity

DDT, acute oral toxicity
Hormones, effect on
   storage of DDT, DDE

Ethyl ferthion, toxicity.
   sex differences
Pesticides, LD-50
DDT, tricliinosis interaction

Carbon tetrachloride damaged
   fivers, effect on
   methoxychlor toxicity

DDT toxicity, effect of fat
   indict
DDT storage, excretion, effect
   of starvation

Dieldrin. effect of dietary
   protein on toxicity
Nutrition, effect on dieldrin
   toxicity
Malathion, effect of
   temperature on toxicity
DDT, Warfarin, Azinphosntethyl,
   effect of temperature
   oo toxicity
292


293

371

409


410

411


417

424

426


427

427

427

428

428
429
429
429
430


431

431


432

432

432
           DDT, temperature, effect on
              physical performance           433
           DNOC. dinitro-o-phcnol,
              toxicity, effect of
              temperature                   433
           Hexachlorobenzcne-induced
              porphyria, photosensitivity      433

           DDT, liver changes                434

           Diekuin, liver changes             435
           Chlo'inatcd hydrocarbons, liver
              ciianges                       435

           Enzyme induction, phenobarbital   436
Technical DDT; p.p '-DDT;
   o,p '-DDT; methoxychlor,
   effects, estrogenic

Chlorprophara, tumorigenicity
   testing

Pyrethrin, tumorigcnicity
   testing

Endosulfan, Clyodin,
   methoxychlor, tumorigcnicity
Metabolism of chemicals

Mali thion, toxicity

Phenobarbital prctreatment,
   cfTict on toxicity

DDT, toxaphene, intake,
   enzyme induction

Enzyme induction measurements
   in progress

Aldrin, Chlordanc, Lindane,
   effect on subsequent
   Parathion poisoning

Tween 20. effect on Beta BHC
   levels

Storage interactions

Aldrin, Dieldrin, interactions

DDT, effect of starvation
                                           437


                                           469


                                           474



                                           475

                                           513

                                           514


                                           518


                                           519


                                           520



                                           524


                                           526

                                           527

                                           528

                                           529
432        Gamma BHC. effect of fat in diet    530
                                                                            179

-------
SUBJECT INDEX
Low protein diet, efccts
Temperature, effects
Radiation, effects

Pipcronyl butoxide, effect on
MDP compounds
Pipcronyl butoxide toxkity
Safrole, effects
DDT, pyrcthrum, pipeionyl
butoxide, liver effects
Piperonyl butoxide, effect
on hexobarbital sleeping time
Metabolism of MDP compounds
Mode of action of MDP
compounds

Host-mediated assay
Dominant lethal test
Teratogenicity testing, use of
tower mammalian species

Organochlorines, embryotoxicity

Thiram, teratogenicity testing

2,4,5-T; effects

RECTUM
Cold water, use in treatment
of poisonings
Pesticide concentrations.
carcinoma of

RENAL
Needed development of methods
for detection of effects
of pesticides
Organophosphatcs, effects
Paraquat poisoning, effects
Occupational exposure, effects

Prcemployrnent examinations
VCNB. renal agenesis
532
533
533


541
542
543
544

546
547

554

594
597

659

664

665

666



451

495




244
347
370
388

443
666
REPELLANT
Avicidcs. anthraquinone,
tliiram

Insect

Development of
Use against mice
Uses
Application form (R)
REPOPULATE
Soil organisms
REPRODUCE
Inhibition of insect reproduction
Cultural or environmental
control

Pesticides, effects in birds
DDT, effect in lake trout

Pesticides, effects in fish

Birds, effects

Dicldrin, DDT. effects in birds

Dicldrin, effects in deer

Chlorinated hydrocarbons.
effects
Effect of pesticides on

Piperonyl butoxide. effects

Somatic mutation methods

Agents which interfere with
ability, mutagenic
Methodologies for teratogenicity
testing
Miscellaneous reproductive
effects
Chlorinated hydrocarbons.
effects

73

75

83
200
215
645

205

83

164

179
209

210

211

212

213


373
437

542

578

602

658

665

674
180

-------
                                 SUBJECT INDEX
RESIDUES
   Of persistent pesticide* in
      environment

   In food, water, restriction of
      exposure

   Consideration of, development
11
of standards
DDT, in fish, environment
Pesticides, Delaney clause
Organophosphatcs
Dieldrin
Persistent pesticides,
development of new pesticides
Organochlorines
Organophosphatcs
Effects on enzyme systems
Spraying of houses with
gamma BHC. use in Chagas
diwa*^
2,4-D in water, effects
Binding to soil particles
2,4-D in water
In water, use of pesticides
In estuaries, levels
In soil, from soil to plants
In seed crops, soil content,
fat content of seeds
Effect of plant
characteristics on
Chlorinated hydrocarbons in diet
Herbicides
Inorganic
Chlorinated hydrocarbons
Toxaphene, in cattle
12
13
14
35
52
59
63
64
81
91
117
118
126
128
129
132
133
134
135
136
137
138
139
 Spraying, cattle                   140

 Mala'.hion in foods                141

 Cuthion                          142

 Alton, soil                       143

 HeptachJor, soil                   144

 In soil                           145

 Resistant crops                    161

 Insect parasites and predators        162

 In food, feed                      170

 Pesticides in soil                   171

 Measurement in foods              173

 Methods for extracting             174

 DDT in food web                  188

 Bromide, fumigants                198

 Bods, effects on                   211

 Ovmical in soil, phytotoxicity      214

 Orpnophosphates                 234

 Tolerances, registration.
   recommended practices          238

 >n foods, cpidcmiological
   complexities                   250

 General population studies          255

 Ingestion, on foods                263

 Of HEOD in tissues                269

Organochlorincs in human
   population                     273

Human, pesticides                  319

Polychlorinatcd biphcnyls           320

Adipose, blood. DDT, DDE          321

DDT, humans, sex differences        322
                                                                               181

-------
                                 SUBJECT INDFX
    DDT. humans, age differences
    DDT, metabolites, effect
       of drugs on

    DDT, place variable

    DDT, time variable
    DDT, discussion

    DDT, dietary source

    DDE, patients

    Secular changes

    DDT, pathologies

    Adipose, humans

    Adipose, humans

    Adipose, humans

    Adipose, humans

    DDT, adipose, effect of age

    Human, DDT, Dieldiin

    Human, DDT, dieldrin

    Human, p.p'-DDE; dieldrin; DDT  340

    Human; p.p'-DDE; dieldrin; DDT  341

    Mortality and morbidity
       studies

    Organophosphates

    DDT. humans

    Chlorinated hydrocarbons,
       effects, birds

    Chlorinated hydrocarbons,
       humans

    Food additive

    Foods, reduction of. DDT, DDD
       in food production

    Pesticides in foods, testing for
       tumorigenicity

    Combined, pesticides
323
323

324

325
325
326
327
328

329

331

332

333

334
335

338

339

340

341

344
347

357


437

447

464

472

478

512
Persistent pesticides
Interactions, pesticides.
detergents

DDT, physiological interactions

Organochlorines
Tissue storage of pesticides
l-'actors determining storage
HOT, DDE, environmental
exposure

Organochlorines

DDT, human placentas

RESISTANCE
To pesticides, factors
influencing changing patterns

Hydrogen cyanide, insecticide
To DDT

To DDT

Rootworms, Organochlorines

Cf pests, chlordane

Of pests
Development of plants
To insecticides, Organochlorines
Need for development of crops

Soldier fly (Australia),
controlled by dieldrin

Frequency of application, effects
Mosquito control, use of
chemicals

Diazinon. use for roaches
Crops
Plants

Bacteria spores, resistant
to conditions
525

526

529

530
536
537

538

539

674



22

45
46

50

52

S3

59
60
63
81


89

108

127

151
161
162


163
182

-------
   Planting of resistant strains

   To diseases, pesticides, effect
      on fish

   Hosi, to pests

   Guinea pig, Guthion

   Ethyl fenthion, rats

   To DDT, fish

   Syncrgists

   Chinese hamster cells

RESPIRATORY
   Fumigants, entrance in body

   Exposure, parathion

   Occupational exposure

   Occupational exposure,
      parathion

   Occupational exposure

   Pesticides, effects in fish

   Exposure, parathion. human*
   Exposure, DDT, humans

   DDT exposure, humans

   Organophosphates, effects

   2,4-D; effects

   Diseases, pesticide exposure

   Organophosphates, effects

   Pesticides, effect on
       I
   Chlorinated phenols.
      effect on

   Occupational exposure

   Signs and symptoms

   Symptoms, occupational
      exposure

   Exposure, parathion

   Failure, acute poisoning
SUBJECT INDEX
167

210
217
426
429

431

542
588

62

112

153
155
itjtj
156
210
£1U
296
296

298
347

350

352

361

369
17ft
JIV
383
389

394
402
416
Satin toxicity, effect of
tempera tine
Condition, pesticide exposure
DDT exposure, humans
Organophosphates, effects

RESTAURANT
Use of lindane, evaporation
materials in
Discontinuance of needed
Use of lindane in.
discontinuation of
Analysis of meals, for DDT
conten:

DDT, DDE, in meals

RETROBULBAR
Thallotoxicosis, production
of neuritis
Chlorinated phenols, neuritis
from

RHINORRHEA
Organophosphorus compounds.
effects of eye contamination
Organophorus compounds, effects
of eye contamination

RHIZOBIUM
Linuron, mutagcnicity
testing in

RHIZOPUS
DCNA. uses
RICE
Endrin, use of insecticides
for posts
Insecticide usage
Rfce crops, use of
insecticides on
Fate of aldrin in
Specific-locus method in pollen

432
443
445
534



23
23

102

114

385



363

367



361

367



642


647


52
84

85
124
578
                                                                             183

-------
                           SUBJECT INDEX
RIVER
DDT, DDE in

DDT contamination of

Ptscicides, uses

Blindness, DDT in
Pesticide pollution of

Aldrin, dicldiin in

Pesticides in
Pesticides in
Pesticides in

Pesticides, effects on fish in

RNA
Enzymes in stratum corneum.
hydrolysis of

Acrylonitrilc, assay system

ROACHES
In households
i
Pests, commercial pest control

Pests, commercial pest control

Chemicals for control
Baits for, need for protection
of household members

ROBIN
Mortality of

Mortality of

RODENTS
Pests
Inorganic rodentitides for
Botanical rodcnticides for
Kepone pellets, use to control
Pesticides, application to
•control

Thaliiuir., as*
Pests

9

13

. 73

91
118

125

128
129
171

210



401

639


147

150

151

309

356


210

211


71
71
72
151

197

309
381
Carcinogcnesis in

DDT, effects in

DDT, effects in

Recommended observation
period in
Enzyme induction in
Dominant lethal test

RODENTICIDES
Compound 1080
And mammalian biocidcs
Botanical
Anticoagulant
Flue ride
Miscellaneous

Need for more toxic

And other mammal biorides

U.S. pesticide production.
annual

Thallium suUatc, uw

Poisoning cases, humans

Anticoagulant, therapy for
poisonings
Application form (Ro)

Endrin, use

RUBBER
Protective clothing, gloves

Protective clothing, gloves

RUST
Fungi
Resistant plants
RYE
Losses due to insects

SABADILLA
Use as louse powders
Botanical insecticides
395

424

425


468
528
596


45
71
72
72
72
72

151

214


315

363

442


451
645

648


77

444


81
162

86


44
62
184

-------
                                SUBJECT INDEX
SALIVA
   Organophosphatcs, effect on

   Mercury in.

   Pesticides, effect on

SALMON
   DDT in

   Pestic'-des in

   Pesticides in

   Pesticides in, effect on food

   Pes»:ades in

SALMONELLA
   Reverse mutation system in

   Host-mediated assay

SARCOMA
   Cocarcinogenic activity of
      sesame oil in production of

SCALP
   Chlorinated acid derivatives,
      effects

SCHISTOSOMIASIS
   PCP, use to control carriers of

SCHIZOPHRENICS
   Improvement by injection of
      acetylchotinc

   Organophosphates, exposure,
      FAA workers

   Improvement of injection by
      acctylcholine

   Preexisting, pesticide exposure

SCREWWORM
   Eradication program

SEAFOOD
   Estuaries, producfon of

SEIZURE
   Organophosphates. halogenatcd
      hydrocarbons, patterns in EEC

SERUM
   DDT, use to decrease bilirubin
      levels, humans
           DDT. DDE in. humans
                               327
360

448
449


118
129

220

357
572

594


543


365


652


413

414

s'18
419

164

220


443

Amino acids in, enzyme
induction
Occupational exposure, albumin
Occupational exposure, amino
acids
Human Monitoring Survey
Teratogenicity testing.
metabolitrs

SEWAGE
DDT, metabolites in
Pesticide;!, treatment
SCOT
Oral exposure to dicldrin.
humans
Occupational exposure to
pesticides
SHEEP
C'asshopper control

Spraying of, with Sevin,
residue study

Storage of dieldrin in
Use of mammalian species for
te-Jng
SHELLFISH
Accumulation of pesticides
Pesticides in
Pesticides in
Marine invertebrates
Consumption of, contamination by
mcthylmeuury, humans, effects
SHOCK
3igns and symptoms of
intoxication
Ingestion of yellow phosphorus.
effects


348
351

388
496

660


9
201


301

351

91


139

265

659

118
120
129
208

675


360

371
300
Experimental carbamatc
   pesticide, effect on rats,
   conditioned avoidance
                                        410
                                                                          185

-------
                                   SUBJECT INDEX
 SHRIMP
    Marine invertebrates                208
    Susceptible to chemicals in
       water                          208

    Heptachlor, cndrin, lindane.
       effect on                       209

    Developmental pheromones         219
    Danger to non-target
       organisms                      219

 SHRUB
    Inorganic insectici Jcs               62
    Lead arsenale, us? on, to
       control chewing insects          62

    Herbicides, effects on nontai;rct     203

 SINUSITIS
    Correlation studies,
       occupational exposure,
       effects                         148

    Association with pesticide
       usage                          3S2

    Correlation studies, effects of
       household exposure to
       pesticides and effects            370

 SKELETAL
    Carbaryl. skeletal
       malalignmcnt in mice            661

 SKIN
    Penetration of, organochlorines     33

    Penetration of, or^anophosphatcs    34

    Absorption through, repellents      75

    Penetration, para t Won              81

    Potential exposure hazards          112

    Penetration, persistent
       pesticides                      135

    Contact, lindane                   149

    Occupational exposure             152

    Penetration, paratnion              155

    Absorption, accidents              158

    Contact. Paraquat,  Dtquat          205
Routes of entry of pesticides        263

Diseases, occupational exposure     307

Serialization reactions,
   dicne group                    349

Hypcrpigmentatioii, freiriUty,
   phenoxy herbicides             350

Topical effects, organophosp^iates   360

Chronic arsenical poisoning,
   effects                        363
Effects on. pesticides               363

Gentian Violet, effects on          364

Nitrogen compounds, herbicides,
   effects on                     365

OccupationaUy related
   conditions                     366

Paraquat, effects on               370

Absorption, poisoning             383

Adsorption, annual intake
   DDT plus DDE                 384

Exposure, decontamination of      400

Cuuneous metabolism             401

LD-50                           402

Parathion exposuic                403

Vehicles, penetration               404

MTtrix                           405
Paraquat, diquat effects            405

Orgauophotphate. effect on         411

Parathion, metabolism in
   humans, effect of pathology     430

Condition, pesticides               443

2,4-D; 2,4,5-T effects on          4SC

Atropinc effects                  43*

Absorption, routes of exposure
   of pesticides, need for
   tciatogenicity testing           657
186

-------
                                 SUBJECT INDEX
SKUNK
   Rodcnticides and mammalian
      bioctdes                        71

SLEEP
   SfcepLig sickness, i x of
      pesticides in                     ?1

   Patterns, organophosptialc
      exposure                       415

   Patterns                          416

   HexobarbiUl steeping time,
      DMSO effects                  417

   Loss, effect r*i Continuous
      Performance Test               418

   fbolinestersse inhibitors.
      effects                         447

   Hexobarbital steeping time.
      effects of orgiqophosphaies on   518

   Hexobarbital steeping time,
      piperonyl butoxide on           546

SLUGS
   Matacfl, use in controlling            72

   Meuidehyde. component of bait*     73

SMOKE
   Sources of pesticides,
      effluents                       242
   Environmental source* of
      pesticides                      242

   Precautions during pesticide
      application                     444

SNAIL
   MataciLuses                        72
   Bayhiscide.uses                     72
   Polystream, utw                    72

   MetaMehyde.use*                   73

   Use of pesticide* for,
      precautions                     103

   DOT in                           120

   Pesticides to cofi'rol,
      precautions                     125

   fCP.utes                         652
SOAP
   Wash for decontamination
      ofskin                        4oo

   Use. to remove pesticide skin
      contamination                 450

SOIL
   Contamination                    22

   Pesticides in, concentration
      in organisms                   25

   Persistence in                     45

   Insects, methoxychlor use          51

   Heptachtor, use                   52

   Chlordane, use                    53

   New methods of application         60

   Organochtorines                   63

   Dithiocarbamate fungicides         66

   Slerilants                         67

   Carboxylic aromatic                68
   Phenoxy herbicides                68
   Benzoic acid herbicide?.             68
   Phthalic acid compounds           68
   Phthalamic acid compounds         68

   Aliphatic acid herbicides            69
   Substituted phenol herbicides        69
   Heterocyclic nitrogen
      derivative herbicides             69
   Substituted ureas                  69
   Carbamates                       69

   Amides                           70
   Dinitroaniline herbicides            70
   Nitrite herbicides                   70

   Cytnate nematocides               71
   Organic phosphate nematocides      71
   Halogenated hydrocarbon
      nematocides                   71

   Plant growth regulators             V4

   Cotton crop*, cyctedienes. a*e       84

   Cereal crops, cyclodienes, use        86
                                 v
   Potato crops, cydodtenej, use        87
                                                                                18?

-------
    Sugar beet oops, cyclodiene, use
    Sugarcane crops, aldrin,
       heptachlor use
    Contamination
    Dieldrinin
    Particles, pesticide adherence to
    Pesticides in, to plants
    Residues, heptachlor, heptachlor
       epoxide, aldrin, dieldrin
    DOT in, residues in potatoes
    Contamination
    Moisture, temperature
    Leaching of pesticides from
    Condition, effect on crop
       resistance
    Pesticide levels in
    Pesticides in
    Storage of pesticides
    Pollution
    Application of pesticides to
    Granules, pellets in
    Pesticides in
    2,4-D; breakdown in
    2,4.5-T; MCPA, breakdown in
    2,4-D; effect on organisms
    Fumigants
    Residue, phytotoxicity
    Spores, milky disease
       bacterium, viability
    Picpatation
    Degradation in
    Pertiddeiin
SUBJECT INDEX
88

89

101

116

118
132
133

141

143

144
144


161

170

171

175

195

198

199

201
203
203
204

205

214

216

218

249

328
DCNA,uses
Dieldrin, uses

Formaldehyde, uses

Panthion, uses

SONIC
Physical pest control methods
Pest control
SORGHUM
Losses due to insects

Cereals

Linuron. use

SOY
Oil seeds, use of chlorinated
hydrocarbons

Caibaryl, use on

Tentative guidelines, crop

Residues of pesticides in

Animal feed

Linuron, use on

Naptalam. use on

SPARROW
Hawk, population decline
Hawk, exposure to DDT,
dieldrin
Hawk, population reduction
from DDT

SPERM
Specific locus test
Captan. effects

DDT, effects

Malcic hydrazide

SPIDER
Mites, affected by fertilizers
647
648
649
652

165
167

 86
 95
650

 90
104
124
133
138
650
651

211

212

665

596
639
640
642

218
188

-------
                                 SUBJECT INDEX
SPINAL
Chlorinated hydrocarbons.
action in, found in

Diazinon poisoning.
pathology in spinal cord

Chlorinated hydrocarbons.
action i.i

SPLEEN
Tests, suitable for assays

HCN (hydrogen cyanide).
tested in

SPROUT
Growth retardunls, effects on
Dicldrin, testing for
mutagcnicity
Malcic hydrazidc, uses
SPRUCE
Spray application for budworms
SQUIRREL
Botanical rodcnticidcs.
strychnine use for



359


367


408


589


640


74

640
651

111


72

DDT, rats, effect of
starvation

Dicldrin, human bl-.od.
effect of starvation

STERILE
Male technique, pest control

Cultural or environmental
control

Injection of juvenile hormone.
effects

Radiation, effects

Induced sterilization
Pesticides, effects on pests
Mutations, effects
Dominant lethal tci.

Adverse genetic effects
STEROID
Effects of, on birds

Enzyme induction by

529


530


82


164


165

167

219
569
571
596

598

211

329
STAMEN
   Somatic mutation methods.
      detection of                   577

   Loss of reproductive
      integrity of                    578
   Use of specimens to detect
      chemical mutations             578

STARLINGS
   Avicides, use to control             73
   AviUol, use to control               73
   Thallium sutfate, use to
      control                         73

   Species rhoscn for monitoring
      of nesticides                   171

   Chemicals, use  to control           214

STARVATION
   Organochlorincs. effects in
      starved animals            .    431
   DDT poisoning in birds, effect
      of starvation                   431
   DDT storage, excretion, in
      rats, effect of starvation         431
   Paraquat poisoning, use of
      steroid therapy, effects of       -10

   Chlorinated hydrocarbons.         '
      alterations in steroid
      metabolism                   373

   DDT, effect on conversion of
      steroids to metabolites         437

STILLBIRTH
   Placenta! transfer of dicldrin
      incidence of stillbirths
      in coivs                       665
   Incidence of stillbirths in
      cows fed DDT                 W5
STOMACH
   Poisons, definition of              61

   Organochlorines, chlorinated
      hydrocarbons, effect from
      p. olongcd stomach action        63

   Carbimates, node of action         65

-------
                                  SUBJECT INDEX
    Altftin, dieldrin exposure.
       diseases, carcinoma of
       the stomach

    Therapy for poisoning

    Pesticide concentrations, in
       persons with carcinoma of
       the stomach

 STOOL
    Safely evaluations, softening
       of stools, high intake of
       cyclamates

    Excretion of pesticides in

 STRINGBEAN
    Fate of malathion residues in

 SUBACUTfc
    Experimental dermal exposure
       to DDT

    End'tin. administered to
       monkeys

    Need for enzyme induction
       studies

    EPN, malathion, feeding
       studies, effects

    Studies, rats

    Need for enzyme induction
       studies

   Toxkity of MOP compounds

    Induction of dominant lethal
       mutations

SUBCUTANEOUS
   Fat, DDT in

   Administration of
      dimethylnitrosmmine.
      carcinogencsii study, mice

   Administration, sesame o3.
      cncinogeiuc, mice

   Aammbaation, Frcon,
      piperonyl butoxidc. mice

   Host mediated assay
                                    3S1

                                    450



                                    495
   Administration, phcnylmcrcurk
      acetate, effects in mice          664

   Methods of testing,
      administration                667

SUBLETHAL
   Effect on nun-target specks,
      need for icv^w of
      pesticides                    29

   Effects on non-target species.
245
401

141

2%

410

510

512
513

519

542


596


264


484

543
545
594
I1CCU 1UI JCVICW Ot
pesticides
Crustacea, effects of
pesticides in
Effects of insecticides on birds
Enzyme induction, rats, mice
Radiation, rats, effects
SUGAR
Beet, crops, use of
insecticides OP.
Beets, use of cyclodienes on
Beet losses due lo insects
Beets, use of acrolcin
Readucs of chlorinated!
hydrocarbons
Cane, use of mongoose to
control rats

Epidemics of poisoning.
panthkm in

SUGARCANE
Aldrin, use to control beetles

Insecticide usage on
BHC/liadane, use to control
pests
Losses due to insects
Biological control, use of
mongoose to control rats
Pentachlorophenol. use on
Simazine, use or.
183

209
211
212
519


84
88
88
124

135

216


310


51

84

*9
89
216
652
653
190

-------
                                  SUBJECT INDEX
SUICIDE
   Pesticide poisonings

   Pesticide poisonings

   Pesticide poisonings

   Pesticide poisonings

   Pesticide poisonings

   Epidemiology of pesticide
      poisonings        :

   Attempted, Paraquat ingestion

SUNFISH
   DDT in

SURGERY
   Obta'ning of samples, for
      population studies

   Pesticides in body tissues,
      samples obtained in

   Specimens of tissues,
      obtained from

   Interactions, effects of
      surgical stress

   Stress, effect on dicldrin
      blood levels, humans

SURVIVE
   Pesticides, effects on birds

   Pesticides, effects on birds

   Transportation of pesticides,
      containers

   DDT, effect on lake trout

   Pesticides, effects on fish

   Single pesticides - all
      diseases

   Temperature, effect on
      pesticide toxicity

   Combined chemicals, effects on,
      mice

   2,4,5-T; effects in rets
157

158

251

306

30S


314

373


120
SWEATING
   Initial sigrr and symptoms of
      intoxication                   360
   Organophosphorus pesticides,
      effects                        360

   Oiganophosphorus compounds,
      effects                        364

   Signs and symptoms in poisoning
      cases                          449

   Cholinestcrasc inhibitors,
      effects of poisoning             450

SWEET
   Organochlorincs, use >o control
      sweet potato weevil             55

255
385
496
525
530
25
179
193
209
210
253
432
546
666
Potatoes, insecticide
usage on
Potatoes, use of cyclodiencs on
Potatoes, naptalam, use on
SWELLING
Nitrogen compounds, paraquat
ingrrtion, effects on liver
SWINE
Vyrethrin, allethrin,
toxicity to
Use of mammalian species for
testing
SYNAPSE
Chlorinated hydrocarbons,
acctylcholinc, effect at
SYNERGISM
Carbamatcs. combination with
pyrethrin synergists
Need for knowledge on
EPN, malathion
Chemicals used to enhance
toxicity
Chemicals used as synergists
for pyrcthroids
Pyrcthrum sprays, effects
Toxicity
84
87
651
373
62
659
524
65
81
523
541
542
545
546

-------
                                   SUBJECT INDEX
    Mode of action of MDP compounds 554
MDP compounds
MDP compounds
SYSTEMIC
Insecticides, phorate,
disulfoton
Organochlorines
Herbicides
Carboxylic aromatic herbicides
Phenoxy herbicides
559
560
60
63
67
68
68
    Vs surface-type pesticides           132

    Insecticides, metabolism by
       plants                         133

    Poisoning, pesticides               307

    Effects, organophosphates          360

    Effects, otganophosphates          361

    Effects, inorganic arsenicals         362

    Poisoning, effects on eye           366

    Absorption. Bidrin, effects          367

    Poisoning, organophosphates        369

    Pentachlotophenol effects          370

    Poisoning, pesticides               383

    Effects, organophosphates          389

    Percutaneous penetration           401

    Poisoning, occupational
       exposure        .              415

    Insecticides, ate in  agriculture       610

    Phosphairadon. use                653

 TACHYCARDIA
    Organophosphorus compounds.
       effects                        371

    Pesticide poisonings, signs
       and symptoms       .           449
 TAIL
    Brown-tail moth, predators
       to control                    152

    Defects, phenylmercuric
       acetate, effect in mice          664

 TAINT
    Vegetables, use of BHC in
       pest control                   87
    Potatoes, use of BHC,
       production of                 87

TANGERINE
    Difolatan, occupational
      dermatitis in groves            365

    Dermatitis, in orchards in
      Japan, due to Difolatan         399

TASTE
    2,4-D in watnr, effect on
      cattle water consumption        117

    Impairment, phenoxy chemicals,
      occupational exposure          350

    Bitter. Baygon exposure           369

TASTELESS
    Anticoagulant rodcnticides         72

    DDT colloidal aqueous
      suspensions                   298

TEA
   Crop, uage of insecticides          84

TEARING
   Organophosphorus compounds,
      effects                       367

   Precautions, pesticide
      operators                     444

   Cholincster.ise inhibitors,
      effects                       446

TERATOGENS
   Information needed on             262

   Search for. in environment          601

   Experimental factors to consider     658

   Circumstances, influence of,
      humans                       659
   Exposure to, humans,
      production of malformations     659
192

-------
                                 SUBJECT INDEX
   Recognition of                   661

   Need for recognition of,
      ways to recognize              662

TERATOGENESIS
   Pesticides                         10

   Needed additional studies on,
      Federal support for             16
   Needed studies                   241

   Captan, folpet, difolatan           438

   DNA alterations, chromosome
      breaks                        60S

   Need for restriction of human
      exposure                      6S7

   Methodologies'for tssting          653

   Methodologies for testing          659

   Testing                          660

   Need for monitoring of            662

   Need for testing,
      interactions in                 663

   Captan, fotpel, effect in
      chicken embryos               664
   Captan, effect in rabbits           664
   Captan, Folpet, effect in mice      664
   Caibary I, effect in beagle dogs      664
   Kelthane, effects in mice          664

   Oiganophosphatei, effects in
      yolk sacs of chick embryos      665
   Thiram, effect in hamsters         665
   2,44-T; effect in mice             665

   2,4-D esters                      666

   Need for studies, pesticides,
      humans                       674

   Organophosphates, humans,
      audits                        675

TERMITES
   Diddrifl.usefor                   52

   Qitordane, use for              _  53
   Aldrin, chlotdane, dieldrin,
      heptachlor, use for              53
   Persistent insecticides, use for       54

   Chlorinated hydrocarbons, use for   63

   Creosote, ptntachloropheno!, use    65

   Rice pests, use of aldrin            85

   Sugarcane, BHC/lindar.e, use
      to control                    89
   Damage from chemical to
      control

   Chlotdane, contamination of
      well water

   Pests, control by pest control
      operators

   Use of persistent pesticides
      for control of

   Fest control
TESTICULAR
   Birds, effects of pesticides on

   DDT, effect on growth of
      cockerels

   Dominant lethal test


THALLOTOXICOSIS
   Symptoms

THICKNESS
   DDE, effects on egg si «Us in
      birds

   DDT. effect on eggshell* in
      birds

   DDT, dieldrin, effects on
      eggshells in birds


THROAT
   Experimental respiratory
      exposure to DDT, effects

   Carbamates and carbamoyl
      oximes, effect on mucous
      membranes

   Inorganic arsenicah, early
      symptoms from ingestion
90


117


ISO


152

195



211


437

596



363



212


437


665



296



361


362


193

-------
                                 SUBJECT INDEX
 THROMBOCYTOPENIA
    Blood dyscrasias. associated
       with chlordane and gamma
       benzene hexachloride           388

 THYROID
    Occupational exposure, pesticides,
       radiation                      255

     lysfunctions, occupational
       exposure, pesticides            351
 TICKS
    Pesi control service, pests
       controlled                     53

    Pes!s, problems of                 58

    Repellents, use for
       protection from                75

    Important pests controlled
       by pesticides                   150

 TIMBER
    Regulation of commodities         55

    DDT, use on                      647

 TINNITUS
    FAA workers, occupational
       exposure to orsanophosphorus
       insecticides, pilots              414

 TOLERANCE
    Zero limits                       10

    Review of, adjustments to          11

    Establishment of                  12

    Organophosphatex                 64

    Natural, rodenticides               151

    Establishment, registration          238

    Levels, foods                      239

    Poisoning cases                    383

    Zero, effects of                    480

    Administration of combinations
       of pesticides                   512

    Theoretical DDT intake            519
   Dkddrin inteSce                   537

   For piperonyl l-utoxide            542

TOMATO
   Vegetable crops                   87
   Use of cyclodienes to control
      pests                         87

   Fate of malathion residues,
      food processing                141
   Residues of L>DT, malathion,
      carbaryl from, in food
      processing                    141

   Resistant straws of plants,
      development of                162

   Parathion sprzying, exposure
      of humans                    445

   Malcic hydrazidc, testing,
      effects                        642

   Lindane, use for crops             650

TONGUE
   DDT in oil, effect on humans       298
   DDT solutions, slightly
      anesthetic to                  298

   Acute DDT poisoning,
      paresthesias of                 359

   Organic mercurial compounds,
      poisoning by.
      paresthesias of                 362

   Paraquat ingestion, ulcers of        373

TOPICAL
   Effects, skin, organophosphatcs     360

   Effects, carbamates                361

   Effects, cholinestense
      inhibitors                     364

   Effects. Paraquat, Dtquat           365

   Contamination, effects on eye       366

   Ophthalmic effects, carbamates
      and carbamoyl oximes          367

   Application TEPP, effects          369

   Exposure, TEPP, effects            406
194

-------
                                  SUBJECT INDEX
TOXIC
   Assessment of, chemical

   Assessment of, needed research

   Needed replacements, pesticides

   Potential, organophosphates

   To plants, petroleum, kerosene,
      cresote, turpentine

   To fish, wildlife, DDT
      substitutes

   To mammals, chcmostcrilants

   To swine, rotenone

   Organophosphates

   Fungicides, bactericides

   To humans, animals, phcncxy
      herbicides

   To humans, warm-blooded
      animals, aliphatic acid
      herbicides

   Amides

   To rodents, humans, roilenticides
      and mammalian biocides

   To rodents, botanical
      rodenticides
   To warm-blooded animals,
      fluoride rodenticides

   To fish, rotenone

   Lindane

   Chemicals, effects on
      non-target organisms

   To budworm, zectran

   Chemical, route of entry

   Quantities, toxaphenc. effect
      on fish

   By skin absorption, pesticides

   Pesticides, residues, intake

   In soil, arsenic
Pesticides, introduction into
14
16
23
34

45

49
60

63

64
65

68


69
70

71

72

72

73
102

105

111
112

119
135

138

145
water system
Rodenticides
Levels, chlorinate*' hydrocarbons
Dose, exposure to TEPP,
endrin, parathion

Less persistent pesticides
Compound, approval of
Degradation products.
formation of

Materials, accumulation in
food chain
Sodium arsenite
Tofish, Dinoscb

Organochlorines, rffects on
molluscs
Antimycin A, effects
Potential, carbamates
Chemicals, use, education
needed
To animals, pesticides, LD-50

Effects, exposure to pesticides

Parathion. respiratory exposure,
humans
Effects, o,p '-DDD, humans
Thallium, effect*

Effect on liver, phenoxy
herbicides
Organophosphates
Acute myocarditis.
organophosphates
Effect on liver.
organophosphates

Administration of dose, time
period
146
151
155

156

161
173

174


192
203
205


208
213
233

237
259

260


296
301
309


350
356

371

373


393
                                                                                  195

-------
   Stria

   Agents, ingestion of,
      by children

   Effects, species variations

   Ncrbormide, effects in rats   -i

   To rats, DEF (Folex)

   Effects, DDT, fat in diet

   To mice, paratWon. effect
      of temperature
   To monkeys, Satin, effect
      of temperature
   To rats, DDT, warfarin.
      azinphosmethyt, effect of
      temperature

   Nitrophenols, effect of
      temperature
   To rats, DNOC, dinitro-o-phcnol
   Parathion, humans, effect
      of temperature
   Ultraviolet light, conversion
      of parathion to paiaoxon

   OUT effects on liver

   Protective equipment, humans

   Chemicals in urine, blood

   Photosensitive hepatic
      porphyria, BHC ingestion

   Responses to chemicals in food

   Effects. EPN, malathion

   Effects. EPN, malathion

   Effects, dieldrin, physiological
      interactions

   Diet, effect on pesticides

   Organophosphates, X-irradiation

   Physical factors, effects

   Piperonyl butoxide, effects

   Effect, piperonyl butoxide

   To plants, animals.
      formaldehyde
SUBJECT INDEX
409

417
424

426

427

431

432
432

432

433
433
433
433

434
444
448


450
478

512

523

529

532

533

534
542
546


649
TOXICANT
Fungicides, bacteiicides
Metaldehyde, use

Fumigants

Use against mice

Insecticides, miticides

DDT, effect on lake trout
Exposure, r umans
Bidrin expcsure. human,
effects
Norbormid:, effect on Norway rat
Effect of t>t in diet, DDT

Effect of MDP compounds
Pipeiony! butoxide, MOP
compounds, eifects
Route of administration.
effects
Synergistic action of

TOXICITY
Scheme for denoting, need for
establishment
Degree of, need to identify
for user

Acute, organochlorincs.
potential
Refined oil.-, effects on plants

Mammalian, DDT substitutes

Mammalian, DDT substitutes

Synergist to increase, formulation
with pyrethrin, aDethrin
Systemic herbicides
To mammals, benzok acid
compounds
In toil, phthalamic acid
compounds

65
73

197

200

206

209
262

367
426
431

542

544

546
554



17

23


34
45

48

49


62
67

68

68
196

-------
                                SUBJECT INDEX
To plants, humans, animals,
   aliphr.tic acid herbicides
To mammals substituted
   phenol herbicides
To mammals, heterocyclic
   nitrogen derivatives,
   herbicides

To humans, dinitroaniline
   herbicides
To mammals, miscellaneous
   herbicides

Scheme, need to devise new

Testing, costs

Oral, zc.-tian

To humans, pesticides, factors
   to consider

Health liazards

Of wastes, municipal and
   industrial waste discharges

Soil contamination

Anticoagulant rodcnticidcs

Data, route of entry

Herbicides, aquatic and
   terrestrial animals

Paraquat, Diquat

Dieldrin, crabs

To cats, anticoagulants

Acute, organochlorines,
   potential

Pesticide, effect of diet on

LD-SO definition

Organophosphates

Dermal, parathkm,
    methyl-parathion

Acute oral, dermal, phosphate
   ester pesticides, LD-SO

Acute oral, dermal, chlorinated,
   hydrocarbon pesticides. LD-SO   313

69

69


69

70
70
77
78

111

112


;?7
143
151
155

203

205
209
215

233
235
259
2%
307

312

313

Organophosphatcs, effects

Organochlorine

Pesticides, effects on
nervous system

Acute, species, LD-SO
Occupational
DDT, rats
Exposure, decontamination
Acute, techniques of
observations

Chronic, percutaneous
penetration
Hair, nail observations.
index of
Behavioral effects of pesticides
Behavioral
Clinical behavioral
Of pesticides, experimental
animals
Animals, humans
Pesticide, tissue culture
Acute, chronic
Acute, DDT
Pesticide, animals, factors
Species, effects on
Age. effect on
Sex, effect on
Disease, effect on
Nutrition, effect on
Temperature, effect on
Light, effect on

Pesticides selected for testing
Interactions, effects on

347

356


359

382
383
388
400

402


403

405
406
407
408

423
424
424
424
425
426
426
427
428
429
431
432
433

481
509
197

-------
                                 SUBJECT INDEX
    Research, enzyme induction.
metabolites
Interact ins. definition
Interactions
Of carboxy esters
Malathion
Malathion, rat
Of pesticides, effect of
enzyme induction
Research, enzyme induction
Exogenous physical factors
influencing
Diet, effect on
Temperature <*ffect on
Radiation., effect on
Insert, pesticide interaction
with synergists
Of synergists
Pipcrony' K xxide
Pipcronj'i butoxide, MDP
compounds
Synergistic, Freons, piperonyl
butoxide
&/-ergislic, p-'peronylb' toxidc
Oril. LD-50, pesticides
Oral. LD-50. pesticides
Oral, LD-50, pesticides
Oral, LD-50, pesticides
Oral, LD-50. pesticides
Oral. LD-50. pesticides
Oral. LD-50, pesticides
Oral, LD-50. pesticides
Oral, LD-50, pesticides
510
511
512
513
513
514
517
521
531
532
533
533
540
541
542
544
545
546
645
646
647
648
649
650
651
65*-*
653
    Perinatal, pesticides in
       human milk                   674

 TOXICOLOGY
    Environmental, need to
       compile and submit data         241

    Complexities                     246

    Epidcmiological approach     ,,-   251

    Animal, skin               .      401

    Industrial, toxic stress             409

    Pesticide, chlordane,
       enzyme induction              517

    Of synergists for pyrethroid
       insecticide chemicals            541

    Mammalian. MDP compounds       542

 TOXIN
    Effect on non-target
       organisms                     217

    Liver toxins, ingestkm by
       humans                       262

    Ingestion of. effects               358

    Thallotoxicosis. symptoms         363

    Organophosphorus compounds,
       effects of poisoning by          369

    Metabolism of. effects on           388

    Cycasin, plant toxin, formation
       of mutagenic metabolic
       products from               _  594

 TRACHEAL
    Fumigants, entrance into
       trachea or respiratory
       system, use against
       insects                       61

 TRANSFUSION
    In severe poisoning                C51

 TRANSMUTATION
    Environmental agents on
       genetics                       568

s-fRANSPLACENTAL
    Chlorinated hydrocarbons          674
    Passage of DDT. DDL              674
198

-------
                                 SUBJECT INDEX
TRANSPLANT
   Organochlorines                   55
   Regulation of imports of
      Irish potatoes and
      transplants                     55

   Studies of tumors                  466

TRAP
   Chemical attractants. use in         75

   Crops, for controlling
      insect pests                    83

   Light traps, use for insect
      control                        166

   Manufacture, precautions          192

   Light, use as insect traps            219
   Sex phcronones. intact traps       2!9

TRAUMA
   Obtaining tissue, blood samples
      from iiuman population         J85

   Miscellaneous behavioral
      changes, causes                418

   Pilot, death, from                  445

TRICHINOSIS
   Interaction of DDT with, rats       429
   Effect on storage of DDT.
      DDE. rats                     429

TF.OUT
   Toxaphene, effect on               119

   Effect of DDT  on eggs of          209
   DDT. effect on reproduction in     209
   DDE, metabolite of DDT, in        209

   DDT, metabolites, in               210

TSSTSE
   Fly, sleeping sickness,
      tranxmissixin                   91

TUBER
   Potato crops                     87
   Moth, DDT. for control of          87

TUMOR
   Screening studies for,
      induction      -               10

   Testing procedures, animals         465
Evaluation of animal               466
Interpretation of results            466

Benign                           467

Induction, judgement
   categories                     468

Induction, judgement
   categories                     469
Induction, compounds judged not
   posiuve                       4/>9
Chcmica'i registered for u«e
   on faxl crops                  469

Induction, compounds judged
   positite                       470
Chemicals registered for use
   on food crops                  470
Chemknk registered but not
   for use on food crops            470

incidence                         473
Chemicals registered for use
   on food crops                  473
Chemicals registered but not
   for use on food crops            473

Incidence                         474
Chemicals registered for use on
   food crops                     474
Chemicals registered but not
   for use on food crops            474

Incidence                         475
Chemicals registered for use
   on food crops                  475
Chemicals registered but not
   for use on food crops            4 /5

Benign, mice                      482

Induction                         483

Incidence, discussion of            486

Recording of, discussion of         487

Pathologic evaluation               488

Incidence, groups, chemicals         489

Animal studies, pesticide!           492
Expected percent of animals with    494


                                 544
MDP compounds, production of.
   lymi>hatic system
                                                                               199

-------
                                  SUBJECT INDEX
   Study. Frcors. piperonyl
      butoxkle                      545

TUMORICEN1CITV
   Categories for judging              461

   Repofts of. pesticides              462

   Index of potential
      carcinogenkity                 -166

   Animal data examined             468

   DDT studies, animals, needed
      research                       471

   Potential                         472

   Incidence of                      473
   Chemicals registered Tor tuc
      on food crops                  473
   Chemicals registered but not
      for use en food crops           473

   Testing needed                    476

   Testing needed, pesticides,
      food residues                  478

   Testing, need for                  479

   Reports of, pesticides              480
   Recommendation for information
      stonge, availability             480

   In animals                        482

   Study for                         488

   Chemical groups, chemicals         489

   Chemical groups, chemicah         490

   Diethylcarbamates                 491
   Ethyl carbamate. Avadex           491
   Chemical groups, chemicals         491

   Animal studies, pesticides           492

   Potential. MDP compounds         543

TURFGRASS
   Inorganic fungicides, use on         66

TURNIP
   Greens, limited markets for
      pesticides                      80
TYPHUS
   D!)T. use in developing
      nations, for control of           9

   DDT. use in halting ej kiemit of     45

   DI/r. use in control of             2%

   High priority uses of
      pesticides, for control of        472
   DDT, use to control, benefits
      from                         472


ULCER
   Peptic, occupational exposure
      to aldrin, dieldrin               351

   Paraquat Digestion, effect
      on tongue, and
      gastrointestinal tract            373

   Prcetnptoymecl examinations
      eyes                          443


ULTR \SOUN >
   Proposed for use against birds       83

   Physical pest control methods.
      ultrasonic energy               165

   Proposed for pest control           167
ULTRAVIOLET
   Light, use in traps for insects        166

   Lfeht; 2,4,5-T presence             203

   Light, environmental factors         249

   Light, effect on oxidation of
      organophosphoius pesticides     433
   Light, conversion of paralhion
      to paraoxon                    433


UNCONTAMINATED
   Estuaries, of importance for
      marine food production          121

   Compressed air, protection of
      workers, occupational
      exposure                      153

   Areas, barriers to prevent
      spread of pesticides              199
200

-------
                               SUBJECT INDEX
IINE
p p '-DDA in. humans, p,p '-DDT
trctment

pj> '-DDA in. human*. P4> '-DDT
in bodyfat

Occupational exposure.
dkldrinin
Panquat, exaction in
Organophosphates, effect on
fjeni to-urinary «y;tcra
DDA in. metabolite of DDT
Paranitrophenol in.
metabolite of panthion

P-mtrophenoi in, parathion
exposure

Carbarylin
DD£ in. monkeys
Biolt gical fluids.
equilibration with brain
DDA in. metabolite of DDT.
humans
Dieldrin in. occupational
exposure
Indicator of exposure
Index of exposure
BHC ingisf *>n.
delta-wninotevulinic acid in
Oximes, excretion
Excretion of ascorbic acid,
6-b-hydroxycortisol hi
Enzyme induction measurements
DieUrinin

Excretion of MDP compounds
Excretion of MDP compounds


?90


291


350
370

373
3*8
388


402

403
427

447
447

447
447
448
450
4S3
520
520
527

547
548
VAGINAL
Testing

Testing. j«tfgn*ncy
determinations

VASCULAR
Diazinon poisoning, deaths.
pathology of organs
VEGETATION
PeneUauon of, by spraying
Intercuanges of pesticides
between '.vater and vegetation
DDT. concet. '.rations in
Control, granule formulations,
use for

VENTILATION
Reduction o' hazards to
employees
Panquat poisoning
Behavioral effects of
solvents, pjed for
Artificial respntion. use in
poisoning cases
VENTRICULAR
Yellow phosphorus ingestion.
EEC pattern simulating
infarction of left
ventricle
Sodnm fluoroacetate, death
bom fibrillation or cardiac
attest
DDT poisoning, animals,
death frort fibrillation
VERTEBRATE
Dynamics of ot^tnochlonnc
insecticides in
Amidase. degradation of
dtaetlKMle. less active
in human !hwt thin other

661


667



367

111

120
120

199



153
370

417

450


371
371
425


263


URTICARIA
   Chlorinated hydrocarbons,
      effects                       446

17TERINE
   DDT, methoxychlor. effect on
      organ weight       •          437
      vertebrates                   514

VINES
   Chlorinated hydrocarbons,
      use on                        84

   Sodium anenite. use as
      potato vjae killer              205
                                                                            201

-------
                                  SUBJECT INDEX
VISIBLE
   Light, use to control insects

   Costs, of environmental
      manipulation

   Chromosome changes, visible
      by microscopy

   Chromosome break*, effects
      on cells
   Contamination of eye by
      organophosphoni i
      compounds, effects

   Or ;anophosphorous compounds,
      effects on

   Organic mcrcuiial pesticides,
      effects

   Airplane pilots, effects on

   Airplane pilot, effects on

   Che linctt erase inhibitors,
      effects on

   Poisoning by oi.vinic
      mercurial ft-.. gkidcs,
      effects

VOMITING
   DDT ingestion. human

   DDT poisoning

   Organophosphates, effects

   Orgknophosphates, eye
      con lamination .effects

   Inorganic arsenical poisoning

   Yellow phosphorus fatgcstion

   Pesticides

   ChlorLiated hydrocarbons

   Economic poisons, effects

   Dinitrophenot,
      pentachlorophenol poisoning
                                     166


                                     304


                                     569


                                     588




                                     361


                                     367


                                     368

                                     406

                                     445


                                     446



                                     448


                                     298

                                     359

                                     360


                                     36 1

                                     362

                                     371

                                     419

                                     446

                                     449


                                     450
 WASP
    Biological control, use of
       parasites against olive
       scale
21
 WASTEWATER
    Research and development needs     24
    Treatment processes for
       elimination of pesticides from     24
   Research and development needs     103
   Treatment processes for
      elimination of pesticide* from     103

WATER
   Persistent pesticides,
      residues ir                      9

   Pesticide residues in,
      restriction!                     1!

   Residues in. environmental
      contamination                  12

   DDT in                           13

   Ground, need for data in            23

   Need for standards                  74

   Dispersal of pesticides               25

   Wash, contamination, industry       27

   Oils on, for mosquito control        62

   Organochtorines. insoluble in         63

   Piscicides. use                      73

   Rice weevil, use of aldrin for         85

   Need for standards                 103

   Route                           116

   2,4-D; contamination of well        117
   Well, analysis for chemicals         117

   Pollution of, surface runoff         118

   Estuarine                         120

   Potable, supply                   111
202

-------
SUBJECT INDEX
Standards, limits
Quality critcru
Treatment processes for
   removing chemicals

2.44); removal from
Toxaphene, BHC. removal from
Removal of pesticides from

Irrigation, contamination of
Aldrin, dhtdrin in

Endrin in

2,4-D; analysis for efter
   application
ODD, analysis for after
   application

Municipal and industrial
Concentrations

Exposure of population

Malathion, removal by

Leaching of pesticides from
   soil by

Leaching of pesticides
   from soil by

Dieldrin in runoff

Introduction of pesticides in

Solutions of anticoagulants,
   use for rodent control

Transportation, contamination
   by accidental spills

Disposal of rinse water

Insect pathogens.
   transport of by

Need for studying pesticides in

Pesticide levels in, program
   to determine

Surface, pesticides in

Exposure of urbar population
   topesticidciin
    122
    122

    122

    123
    123
    123

    1 24
    1 24

    125
    126

    / 76


    127

    128

    138

    141


    143


    144

    145

    146


    151


    157

    1 59


    163

    169


    170

    171


    172
 v 'easurements of pesticides in        173

 Pesticides in, concentration
   in organism'.                    179

 Contaminated «ash, industry,
   needed improvements           181

 Leakage of pcricides in             192

 Disposal of pesticides,
   avoidance of                    194
Contamination of, agricultural      195

Mosquito control                  197

Transport vehicle for pesticides     198

Contamination. Dinoseb.
   effects on mirine life           205

Fhytoplankton in                  207

Marine invertebrates               208

Marine organisms, effect of
   pesticides oa                   210

Fish-eating buds, effect of
   toxaphenc                     211

Degradation of Antimycin A in     213

Management                      218

Organophospnates. accidental
   spills in                        234

Samples,  surveillance needed        242

DDT in, human exposure, effects    298

DDT in                          326

Estimates for annual intake,
   DDT plus DDE                 384

Parathion exposure, removal of     400

DDT in diet, rats, effect
   on ability to swi/.i in            433

Sodium sulfate in, therapy for
   poisoning                     450

Contamination, need to reduce      472
                                               203

-------
                                  SUBJECT INDEX
    Pesticides in. legislative
       needs

    Pollutants, exposure of humans

    Application form, (WML) water
       irascible  liquid. (WSO water
       soluble concentrate

    SoKibi; compounds, administration.
       teratogenkity testing
 WATERFOWL
    Pesticides, management of

 WATERSHED
    Crops in. pvathion applied to

    DDT. control of gypsy moth,
       flies in

 WEANLING
    Acute loxicity of
       anticholinesterasc
       insecticides, weanling vs.
       adult rats
    DEF (Folex) loxicity to rats
    Toxicity of DDT, effect of age

    Methodologies for
       teratogcniciry testing

 WEATHERING
    Metal salts, persistence in
       soil, removal of by

    Formulation and application
       method, effect on pesticide

 WHEAT
    Growth retardants, effects
     f
    Losses due to insects

    Grown in soils treated with
       DDT, dieldrin, residues in

    Resistant plants

    Integnted control techniques

    Avicides. growing of crops
       on soil, residues

    Pest. Hessian fly, host
       resistance to pests
Timing of planting
480
598


645



2!3

144

209



427
427
427

658


45

143

74

86


133
162

167

214


217
environmental manipulations
Parathion in, epidemics of
poisoning
BHC contamination of.
ingcstion, humans
Linuron, use
WILDLIFE
DDT. DDE in
Need :o augment efforts to
protect
DDT substitutes, hazards to
Repo>ting of adverse effect on

Organ ^chlorines, effect on
Rode Uicidcs did mammalian
biocidcs
Pesticides in

Pest control of structures.
precautions
Seed treatments, effects
Herbk*d'*s, effects on
Paraquat, diquat, effects on

Organophosphatcs, hazards to
Rep Kting of hazards to
Polyc'ilorobiphenyb in

Poisoning investigation, need for

Anticholinesterase insecticides.
cumulative effects on, need
for evaluation
Cumulative effect of pesticides
on cholinesterase and
aliesterase activity in.
need for evaluation
WINE
Growers, occupational exposure
to arsenical insecticides,
effects
218

310

450
650

9

15
49
51

56

71
171


195
200
205
205

234
241
257

356



510



514



363
204

-------
                                 SUBJECT INDEX
W1REWORMS
   Aldrin, use to control
   Methoxychlor, use

   Cotton crops, cyclodienes
      use to control

   Cereals, use of BHC to control

   Potatoes, use of cyclodiencs
      to control

   Tobacco, use of cyclodiencs to
      control

   2,4-D; effect on

WORMS
   Eradication program for
      screw worm

   Eradication program for
      screw worms

   Cereal crept, use of
      cyclodienes to control

   Tobacco, use of DDT to control
      foliagt pests

   Death, after treatment of
      ponds with DDT

   Control of screw-worm fly.
      induced sterilization

   Chloroform, use for screw
      worm control
51
51
84
85
87
89
204
82

83
85

89
208
219
e^At.
Parathion, use to control
YEAST
Acrylonitrilc, testing, effects
YOLK
DDT, effect on reproduction
in lake trout
Concentration of DDT in fish
eggs
Organophosphates, teratogcnic
when injected into yofk sac
of chick embryos
ZERO
Tolerance liruts
Tolerances, effect of
imposition of
DDT levels in pond
Robin population
Incidence, concept of
Incidence, testing procedures
Tolerance, effect of
imposition of
Dose spacing
ZYGOTE
Dominant lethal test
Dominant lethal test
652
639
209
209
665
10
11
120
211
393
465
480
493
596
597
                                                                               205

-------
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                                   BIBLICGRArHY


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310

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[BIBLIOGRAPHIC DATA i. KCj>ort NO. * 2.
SHEET BPA-540/9-69-Q02 (HEW)
4. Title nnJ Subtitle
Index to the Report of the Secretary's Commission on Pesticide
and Their Relationship to Environmental Health
7. Author(s) Sharon L. Valley, Ph.D., Toxicology Information Program
National Library of Medicine
9. Performing. Organization Name and Address
National Library of Medicine
8600 fockville Pike
Bethesda, Maryland 20014
12. Sponsoring Organization Name and Address
U.S. Department of Health, Education, and Welfare
Public Health Service
National Institutes of Health
3. Recipient's Accession No."
5. Report Date
! . 1969
6.
' No! rmmS r**n'™lon ePf'
10. Projcct/Taslc/Work Unit No.
11. Contract/Grant No.
13. Type of Report & Period
Covered
14.
15. Supplementary Notes
)6. Abstracts
The indexes in this publication were designed to assist users in' rapidly finding
information in "The Report of the Secretary's Commission on Pesticides and Their
% Relationship to Environmental Health", This publication consists of three indexes:
                                                                                                                       (•
                                                                                                                       •-'i
                                                      ,
    /} a Chemical Substances  Index;  a Subject Isii^^. nl

fe*
    "• Key ttfords and Dccuaieti. Analysis.   I7o. Descriptors


       Too numerous to list,
    7V. Uemifiers/Opea-Eoded Terns
    7c. COSATI Field/Croup
   ^on»« M1
                                   O BY ANM AND UNhSCt).
                                                                       19. Security Class (This
                                                                          Report)
                                                                             UNCLASSIFIf-n
                                                                        M  J  V  I v^^n.-..-.* *'•"
                                                                       20. >ccu.-s-y t'i.iss (This
21. No. of Pages
                                                                                                 32. Price
                                                                Tills «>KM MAV I1H Kt-IMUMHirKD     USCOMM-DC •'ei^T*

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