GUIDANCE FOR THE
REREGISTRATION OF PESTICIDE PRODUCTS
CONTAINING AS THE ACTIVE INGREDIENT
METOLACHLOR
(108801)
CASE NUMBER 0001
CAS 51218-45-2
U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20460
JANUARY 1987
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TABLE OP CONTENTS
Page
I. Introduction ...................... 1
II. Chemical (s) Covered by this Standard .......... 2
A. Description of Chemical
B. Use Profile
III. Agency Assessment . . ................. 6
A. Summary
B. Preliminary Risk Assessment
C. Other Science Findings
D. Tolerance Reassessment
IV. Regulatory Position and Rationale ............ 15
A. Regulatory Positions
B. Criteria for Registration
C. Acceptable Ranges and Limits
D. Required Labeling
V. Products Subject to this Standard ........... 23
VI.. Requirement for Submission of Generic Data ....... 24
':A.. What are generic data?
B. Who must submit generic data?
C. What generic data must be submitted?
D. How to comply with DCI requirements
E. Procedures for requesting a change in protocol
P. Procedures for requesting extensions of time
G. Existing stocks provisions upon suspension or
cancellation
VII. Requirement for Submission of Product-Specific Data . . 29
VIII. Requirement for Submission of Revised Labeling ..... 30
IX. Instructions for Submission ............... 31
A. Manufacturing use products (sole active)
B. End use products
C. Addresses
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APPENDICES
I. DATA APPENDICES
Guide to Tables
Table A
Table P
II. LABELING APPENDICES
Summary of label requirements and table
40 CFR 162.10 Labeling Requirements
Physical/Chemical Hazards Labeling Statements
Storage Instructions
Pesticide Disposal Instructions
Container Disposal Instructions
III. USE INDEX APPENDIX
IV. BIBLIOGRAPHY APPENDICES
Guide to Bibliography
Bibliography
Addendum to the Bibliography
;V. FORMS APPENDICES
EPA Form 8580-1 FIFRA §3(c)(2)(B) Summary Sheet
EPA Form 8580-6 Certification of Attempt to Enter Into an
Agreement with Other Registrants for Development
of Data
EPA Form 8580- Formulator's Exemption Statement
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I. INTRODUCTION
The Registration Standards Program
EPA has established the Registration Standards program
in order to provide an orderly mechanism by which pesticide
products containing the same active ingredient can be reviewed
and standards set for compliance with PIPRA. The standards
are applicable to reregistration and future applications for
registration of products containing the same active Ingredient.
Each registrant of a product containing an active ingredient
subject to this Standard who wishes to continue to sell or
distribute that product must bring his product and labeling
into compliance with FIFRA, as instructed by this Standard.
Pesticides have been grouped into use clusters and will be
reviewed on the basis of a ranking scheme giving higher
priority to (1) pesticides in clusters used on food and feed
crops; and (2) pesticides produced in large volumes.
The Registration Standards program involves a thorough
review of the scientific data base underlying a pesticide's
registration. The purpose of the Agency's review is to
reassess the potential hazards arising from the currently
registered uses of the pesticide; to determine the need for
additional data on health and environmental effects; and to
de'termine whether the pesticide meets the "no unreasonable
adverse effects" criteria of PIPRA. In its review EPA identifies
1. Studies that are acceptable to support the data
requirements for the currently registered uses of the
pesticide.
2. Additional studies necessary to support continued
registration. The additional studies may not have been
required when the product was initially registered or may be
needed to replace studies that are now considered Inadequate.
3. Labeling revisions needed to ensure that the product
is not misbranded and that the labeling is adequate to protect
man and the environment.
The detailed scientific review, which is not contained
in this document, but is available upon request, focuses on
the pesticide active ingredient. The scientific review
primarily discusses the Agency's evaluation of and conclusions
from available data in its files pertaining to the pesticide
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active ingredient. However, during the review of these data
the Agency is also looking for potential hazards that may be
associated with the end use products that contain the active
ingredient. The Agency will apply the provisions of this
Registration Standard to end use products if necessary to
protect man and the environment.
EPA's reassessment results in the development of a
regulatory position, contained in this Registration Standard,
on the pesticide and each of its registered uses. See
Section IV - Regulatory Position and Rationale. Based on its
regulatory position, the Agency may prescribe a variety of
steps to be taken by registrants to maintain their registrations
in compliance with PIFRA. These steps may include:
1. Submission of data in support of product registration;
2. Modification of product labels;
3. Modifications to the manufacturing process of the
pesticide to reduce the levels of impurities or contaminants;
4. Restriction of the use of the pesticide to certified
applicators or other specially trained individuals;
• -,. 5. "'Modification of uses or formulation types; or
6. Specification of packaging limitations.
Failure to comply with these requirements may result in
the issuance of a Notice of Intent to Cancel or a Notice of
Intent to Suspend (in the case of failure to submit data).
In addition, in cases in which hazards to man or the
environment are identified, the Agency may initiate a special
review of the pesticide in accordance with *JO CFR Part 151*
to examine in depth the risks and benefits of use of the
pesticide. If the Agency determines that the risks of the
pesticide's use outweigh the benefits of use, the Agency
may propose additional regulatory actions, such as cancellation
of uses of the pesticide which have been determined to cause
unreasonable adverse effects on the environment.
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EPA has authority under the Data Call-in (DCI) provisions
of PIFRA sec. 3(c)(2)(B) to require that registrants submit
data to answer our questions regarding the chemical, toxicological,
and environmental characteristics and fate of a pesticide.
This Registration Standard lists the data EPA believes are
necessary to resolve our concerns about this pesticide.
These data are listed in the Tables A and B in Appendix I.
Failure to comply with the DCI requirements enumerated in
this Registration Standard may result in issuance by EPA of a
Notice of Intent to Suspend the affected product registrations.
Registrants are reminded that FIFRA sec. 6(a)(2) requires
them to submit factual information concerning possible unreason-
able adverse effects of a pesticide at any time that they
become aware of such information. You should notify the
Agency of any information, including interim or preliminary
results of studies, if those results suggest possible adverse
effects on man or the environment. This requirement continues
as long as your products are registered by the Agency.
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II. CHEMICAL COVERED BY THIS STANDARD
A. Description of Chemical
The following chemical is covered by the Registration
Standard:
Common Name: Metolachlor
Chemical Name: 2-chloro-N-( 2-ethyl-5-methylphenyl)-
N- (2-methoxy-l-methylethyl) ace t amide
Chemical Family: Chloroacetanllide
CAS Number: 51218-U5-2
OPP (Shaughnessy) Number: 108801
Empirical Formula: CicjHjpClNC^
Trade Names: Dual, CGA-24705; Ontrack, Pennant
Physical characteristics: White to tan; Liquid; M.W. :
238.8; Boiling Point: 100 °C at 0.001 mmHg;
Odorless; Solubility: 530 ppm in water at 20 °C;
Miscible with xylene, toluene, dimethyl formamide,
methyl cellosolve, butyl cellosolve, ethylene
dichlorlde, and cyclohexanone; insoluble in ethylene
glycol and propylene glycol; Vapor Pressure:
about 10~5 mmHg at 20 °C.
B. .Use Profile
Metolachlor is a selective herbicide registered
for the control of annual grasses and broadleaf weeds in
terrestrial crop areas including corn (field, sweet, and pop),
sorghum, cotton, potatoes, peanuts, soybeans, green beans,
kidney and other beans, blackeye and other peas, stone fruits,
and tree nuts; and terrestrial noncrop areas including ornamental
nursery plants and along railroads and highways. Metolachlor
may be applied by conventional ground sprayer equipment and
incorporated before planting, or as a preemergence herbicide
applied during or after planting but before weeds or crops emerge.
Applications can also be made through center pivot irrigation
systems or by aircraft. Metolachlor is in a class of herbicides
which are general growth inhibitors, especially of root elongation
It may also disrupt the integrity of plant cell membranes,
and inhibit lipid synthesis.
Estimated total current amount of metolachlor applied
in the United States is 50,000,000 pounds of active ingredient
(ai) per year. Agriculture accounts for 99 percent of the
usage. The major use sites and percent of crop treated are
field corn (19%), soybeans (1155), sorghum (13%), and peanuts
Metolachlor was first registered for use in 1976 and
is produced solely by Ciba-Geigy Corporation, Agricultural
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Division, Greensboro, North Carolina from active ingredient
manufactured outside the United States. Metolachlor is available
as a Technical Grade Manufacturing-Use Product; an 86.^% (ai)
Emulsifiable Concentrate; 5, 15, and 25% Granulars; 27.5?,
31.855, and 36.155 Plowable Concentrates with atrazine, a 36.3/6
Plowable Concentrate with propazine, and a 73.655 Emulsifiable
Concentrate with metribuzin.
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III. AGENCY ASSESSMENT
A. Summary
The Agency issued the orginal registration standard
for metolachlor in 1980. The data required by that standard
have been submitted and evaluated. Because of changes in
the data requirements since 1980 and the finding of metolachlor
in surface and ground water, new data gaps have been identified.
Based on available data the Agency has reached the following
conclusions. A detailed discussion of the points summarized
below appears in Section B.
1. Metolachlor chronic toxicity data indicate
weak evidence of oncogenicity, and is tenatively classified
as showing limited evidence of carcinogenicity in animals.
2. Metolachlor has been found in several surface
water surveys, some tap water samples, and in ground water in
two States. Monitoring studies are required to determine the
extent of contamination on a national scale.
As a result of this review, the Agency has identified
additional data necessary to evaluate the environmental and
humane-risks associated with the use of metolachlor. These data
must be 'developed in order to maintain registration of products
or to register new products containing metolachlor. A summary
of these data gaps appears in Table 1. Please note that
this is only a summary and complete details can be obtained
by referring to the tables in Appendix I.
The Agency has also determined that certain label
restrictions or revisions are necesary. These include:
Ground Water and Surface Water Advisory Statements
Crop Rotation Restriction
Endangered Species Precautionary Statements
The Regulatory Position and Rationale Section
discusses the Agency's position on these restrictions and the
Required Labeling section contains the specific wording
required for each of the labeling revisions.
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Table 1
Metolachlor - Data Gaps
(Please refer to the tables in Appendix I for
detailed information regarding these requirements.)
Toxicology
Mutagenicity Studies
General Metabolism
Effects on Coagulation
Environmental Pate
Hydrolysis
Photodegradation Studies
Metabolism Studies
Mobility Studies
Accumulation Studies
Ground and Surface Water Monitoring
Product Chemistry/Residue Chemistry
Product Chemistry
Plant Metabolism
.Storage Stability
Selected Residue Studies
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B. Preliminary Risk Assessment
Certain data gaps exist for raetolachlor and definitive
conclusions cannot be made until the required data are received.
The following assessment Is based on the data available and
is, therefore, subject to change.
1. Chronic Peeding/Oncogenicity Data. Metolachlor
is considered adequately tested for chronic feeding and
oncogenic effects in laboratory animals. It is considered an
oncogen In rats but not in mice, as described below.
A 2-year chronic feeding/oncogenlcity study
with Sprague-Dawley rats was performed at Industrial Biotest
Laboratories (I3T). Although validated, the study is
supplementary because of several deficiencies in protocol,
including dose levels which could not be verified. Conducted
at dietary doses of 0, 30, 300, and 3000 ppm, the study
had a statistically significant increase In primary liver
neoplasms in females of the high-dose group.
A repeat chronic feeding/oncogenicity study In
Sprague-Dawley rats conducted at the same dietary doses as •
the original study with 60 animals of each sex at each dose
level had a systemic NOEL of 30 ppm (1.5 mg/kg), a systemic
"LEL o'f-:300 ppra {testicular atrophy), and a statistically
significant Increased Incidence of neoplastic liver nodules
and proliferative hepatic lesions in females of the high-do^se
group (3000 ppm).
A valid IBT oncogenicity study conducted with
Charles River CD-I mice had no observed oncogenic potential
at 30, 1000, and 3000 (429 mg/kg). A repeat oncogenicity
study with Charles River CD-I albino mice with 52 animals of
each sex and at each dose level had no observed oncogenic potential
at the same dose level as the original study. A decrease in
body weight gain at the highest dose tested In males and
females indicated that 3000 ppm was a Maximally Tolerated Dose.
2. Mutagenicity Data. Available mutagenicity
information is negative.
A bacterial (Salmonella) system (Ames Assay)
was tested for base substitutions and point mutations at 10,
100, 1000 and 10,000 ug/plate and no increase over background
mutation rates was observed.
In a mouse dominant lethal test no effects were
noted on fertility rates, or on zygote or embryo survivals,
after single oral doses of 100 and 300 mg/kg. No malformations
of resulting embryos were reported. However, additional
testing is required because of the relative Insensitivity of
the test.
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Additional testing is required for in vitro
gene mutation in a mammalian cell system, chromosomal aberration,
and direct DNA damage.
3. Metabolism Data. Animal metabolism testing is
needed to satisfy current requirements.
4. Subchronic Feeding Data. A 6-month subchronic
study was conducted with beagle dogs in which equal numbers of
males and females were dosed with metolachlor at 0 (8/8),
100 (6/6), 300 (6/6), and 1000 (8/8) ppm in the diet. Possible
compound-related effects consisted of a decreased gain in
body weight in males and fema-les and a failure of the serum
alkaline phosphatase to decrease with increasing age in both
sexes. The NOEL in the study was 100 ppm. A reevaluation
of this study indicated statistically significant decreases
in activated partial thromboplastin time (APTT) in males and
females at 300 and 1000 ppm. Rather than the reported error
in methodology, this may be a compound-related effect.
Therefore, a special study on effects of metolachlor on the
blood clotting system in the dog is required. The requirement
for this additional study does not impact on the NOEL of 100
ppm which has been established from the subchronic study.
5. Reproduction and Teratology Data. Metolachlor
i's considered to be adequately tested for teratogenic and
reproductive effects. It is not considered to be either
teratogenic in rats or rabbits or to cause adverse reproductive
effects in rats, as discussed below.
A teratology study conducted with Sprague-Dawley
rats given oral doses of 0, 60, 180, or 360 mg/kg/day of
metolachlor did not affect the offspring. The only possible
effect on the rats was a decrease in food consumption at the
highest dose during the first one-third of the experiment which
may indicate that this was the beginning of toxic maternal
doses.
In a teratology study conducted with New Zealand
White rabbits given oral doses of 0, 36, 120, and 360 mg/kg/day
of metolachlor, no evidence of compound-induced fetoxocity or
teratogenicity was observed. Maternal toxicity was observed
at the high dose.
In a two-generation reproduction study conducted
with Charles River rats given oral doses of 0, 30, 300, or
1000 ppm of metolachlor, no direct effects on reproduction
were shown including the highest dose. The NOEL for reproductive
effects is 300 ppm based on reduced pup weights and reduced
parental food consumption at 1000 ppm. Other effects that
may be related to treatment were increased liver to body
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weight and thyroid to body weight ratios in the 1000 pptn Fj
parents. The effects on pup weights at 1000 ppm can be considered
secondary to the reduced food consumption of the dams.
6. Oncogenic Risks: The Agency has concluded that
the data available constitutes limited evidence of oncogenicity
under the EPA Proposed Guidelines for Carcinogen Risk Assessment
(November 23, 1984, 49 FR 46294). Therefore, metolachlor is
tentatively classified as a Category C carcinogen (limited evidence
of carcinogenicity in animals) for the reasons given below:
a. The oncogenic resonses observed with
metolachlor were confined solely to the
high dose females at one site (liver)
in Sprague-Dawley rats.
b. The proliferative liver lesions were primarily
benign (neoplastic nodules - 6 in 60 animals)
rather than hepatocellular carcinomas (1 in 60
animals). There was no apparent difference
in the time-to-occurrence of the lesions
(almost all liver tumors were observed -at
terminal sacrifice).
c. Metolachlor is not oncogenic in Charles River
CD-I mice.
d. Metolachlor is not mutagenic in available
assays (an Ames test and a mouse dominant
lethal test).
The Agency previously made a tentative risk
assessment based on the IBT rat oncogenicity study. Assuming
a Q* = 2.1 x 10~3 (rag/kg/day)-I and using a Theoretical
Maximum Residue Contribution (TMRC) of 0.0755 mg/kg (1.5 kg diet),
the "worst case" dietary risk was calculated to be 3 incidences
in a million (3 x 10~°). Using the TMRC provides a conservative
estimate since it does not consider the effect of processing
on residue levels in the raw agricultural commodity, that actual
residue levels may be lower than the established tolerance, and
that less than 100 percent of the crop is treated.
Based on preliminary exposure estimates for use
of metolachlor on corn, and the Q* from the IBT rat study,
the following ranges in risk numbers were calculated:
mixer/loader (farmer): (10~7 - 10~8)
mixer/loader (custom applicator): (10~° - 10~7)
applicator (farmer): (10~5 - 10-°)
custom applicator: (10"1* - 10~5)
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7. Ground Water and Surface Water Contamination.
Metolachlor has been found in several surface water surveys.
Transient peaks of 1.2 to 4.4 ppb are reported in river
water possibly as a result of runoff during spring and summer.
Detectable levels of metolachlor were found in some tap water
samples. Metolachlor has the potential to leach and has
been found in ground water in two States. Since the extent
of contamination is unknown on a national scale, monitoring
studies are required. A ground water advisory statement
will be required on the label.
C. Other Science Findings
Environmental Pate. Available environmental fate
studies provide only limited information. Although the
Metolachlor Registration Standard issued in September 1980
discusses certain studies, the previously submitted data
are not adequate by current standards and procedures.
Ecological Effects. Data indicate that metolachlor
is practically nontoxic to birds. It is slightly toxic to
aquatic invertebrates, and moderately toxic to fish.
-D. Tolerance Reassessment
Tolerances have been established for residues of
metolachlor and its metabolites in raw agricultural commodities,
milk, eggs, meat, fat, and meat byproducts (mbyp) [40 CFR
§l80.368(a)] as follows:
Commodities Parts Per Million
Almond hulls 0.3
Cattle, fat 0.02
Cattle, kidney 0.2
Cattle, liver 0.05
Cattle, meat 0.02
Cattle, mbyp (except kidney
and liver) 0.02
Corn, fresh (inc. sweet,
kernel plus cob with
husk removed) 0.1
Corn, forage and fodder 8.0
Corn, grain 0.1
Cottonseed 0.1
Eggs 0.02
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Commodities Parts Per Million
Goats, fat 0.02
Goats, kidney 0.2
Goats, liver 0.05
Goats, meat 0.02
Goats, mbyp (except
kidney and liver) 0.02
Hogs, fat 0.02
Hogs, kidney 0.2
Hogs, liver 0.05
Hogs, meat 0.02
Hogs, mbyp (except
kidney and liver) 0.02
Horses, fat 0.0?
Horses, kidney 0.2
Horses, liver 0.05
Horses, meat 0.02
Horses, rabyp (except
kidney and liver) 0.02
Legume vegetables group
foliage (except soybean
forage and soybean hay) 15.0
Milk. 0.02
Peanuts . '-0.5
Peanut, forage and hay 30.0
Peanut, hulls 6.0
Peppers, chili 0.5
Potatoes 0.2
Poultry, fat 0.02
Poultry, liver 0.05
Poultry, meat 0.02
Poultry, mbyp (except
liver) 0.02
Safflower seed 0.1
Seed and pod vegetables (except
soybeans) 0.3
Sheep, fat 0.02
Sheep, kidney 0.2
Sheep, liver 0.05
Sheep, meat 0.02
Sheep, mbyp (except
kidney and liver) 0.02
Sorghum, forage and fodder 2.0
Sorghum, grain 0.3
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Commodities Parts Per Million
Soybeans 0.2
Soybeans, forage and hay 8.0
Stone fruits group 0.1
Tree nuts group 0.1
Tolerances have been established [40 CPR §l80.368(b)]
for indirect or inadvertent residues of raetolachlor as a
result of application of metolachlor to the growing crops
listed in §l80.368(a), as follows:
Commodities Part Per Million
Barley, fodder 0.5
Barley, forage 0.5
Barley, grain 0.1
Buckwheat, fodder 0.5
Buckwheat, forage 0.5
Buckwheat, grain 0.1
Millet, fodder 0.5
Millet, forage 0.5
Millet, grain 0.1
Milo,. fodder 0.5
Milo, forage 0.5
Milo, grain 0.1
Oats, fodder 0.5
Oats, forage 0.5
Oats, grain 0.1
Rice, fodder 0.5
Rice, forage 0.5
Rice, grain 0.1
Rye, fodder 0.5
Rye, forage 0.5
Rye, grain 0.1
Wheat, fodder 0.5
Wheat, forage 0.5
Wheat, grain 0.1
Canadian tolerances of 0.1 ppm have been established
for residues of raetolachlor in or on beans, corn, peas,
potatoes and soybeans. No Mexican tolerances or Codex
Alimentarius Commission Maximum Residue Limits have been
established for residues of metolachlor.
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EPA has evaluated the residue and toxicology data
supporting these tolerances and reviewed all uses of metolachlonJ
Based on available data, the following conclusions have been
made regarding residues of metolachlor:
o The metabolism of metolachlor in root crops is
not adequately understood. A potato metabolism
study is required.
o Storage stability data are required.
o Processing studies ar° required for potatoes,
soybeans, field corn, cottonseed, and peanuts.
o Residue data are required for succulent and dried
beans treated with the 25% granular formulation
of metolachlor.
o The present seed and pod vegetables commodity
expression which includes okra is now obsolete.
40 CFR SlB0.368(a) will be editorially corrected to
read beans (succulent and dry) and peas (succulent
and dry).
o All other tolerances are supported with adequate
residue data.
Pending receipt of the additional studies, the
Agency will evaluate new uses and new tolerances on a case-by-
case basis. If the incremental risks are not significant the
Agency will continue to establish new tolerances. However,
the Agency does not intend to establish food additive tolerances
under Section 409 of the Federal Food, Drug and Cosmetic Act due
to the Delaney Clause which bars establishment of food additive
regulations for substances which induce cancer in man or test
animals. Comments will be solicited on this issue regarding
metolachlor and other pesticides which have produced a positive
oncogenic response in animal studies.
The acceptable daily intake (ADI) for metolachlor
is based on the rat chronic feeding study with a NOEL of 30 ppm
and a systemic LEL of 300 ppm (testicular atrophy). Using
the NOEL of 30 ppm (1.5 mg/kg/day) and a safety factor of 100,
the ADI is 0.015 mg/kg/day, and the maximum permissible intake
(MPI) is 0.9 mg/day for a 60 kg person. The established
tolerances result in a total theoretical maximum residue concen-
tration (TMRC) of 0.0755 mg/day (1.5 kg diet) which corresponds
to 8.38 percent of the MPI for a 60 kg person.
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IV. REGULATORY POSITION AND RATIONALE
A. Regulatory Positions and Rationales
Based on review and evaluation of all data available
on metol.achlor, the Agency has made the determinations below.
Refer to Section IV. D. for specific language for label
revisions.
1. None of the risk criteria listed in 40 CPR 154.7
for initiating a Special Review have been met. Therefore,
metolachlor is not being placed in Special Review at this
t ime.
Rationale; After considering available toxicology
data, the Agency has determined that no reason exists for
placement of metolachlor in Special Review at this time.
Metolachlor has tentatively been classified as a Group C
carcinogen (limited evidence of carcinogenicity in animals) and
appears to pose minimal risk of causing cancer in humans.
2. The Agency does not intend to establish new
food additive regulations pursuant to Section 409 of the
Federal Pood, Drug, and Cosmetic Act (PFDCA)
''..."-:-;- Rationale; The Delaney Clause in Section 409
of the FPDCA bars the establishment of food additive regulations
for substances which induce cancer in man or test animals,
with exceptions that do not apply here. Metolachlor has been
found to produce an oncogenic response in test animals. The
Agency will be soliciting comments on Delaney Clause issues
regarding metolachlor and other pesticides or metabolites
which have produced positive oncogenic responses in chronic
animal studies.
3. The Agency will continue to approve new uses
for Section 3 or 24(c) registrations for metolachlor on a case-
by-case basis.
Rationale; While data gaps exist in the areas
of environmental fate, residue chemistry and toxicological
effects, these gaps do not preclude the Agency from determining
that a new use will not result in unreasonable adverse effects
to humans and the environment. The Agency will review and where
appropriate may approve such applications for new uses of
metolachlor.
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4. The Agency is requiring monitoring studies for
ground water and surface water contamination.
Rationale; Metolachlor has been found in
several surface water surveys and in ground water in two
States. Monitoring studies are required to assess on a
national scale the extent of contamination.
5. The Agency is requiring a ground water and a
surface water advisory statement to appear on all end-use
products with metolachlor.
Rationale; Metolachlor has been found in
surface and ground water apparently as a result of its
agricultural use. The label advisory statements will
emphasize to users the need to exercise care when mixing and
applying metolachlor in order to limit the possibility of
leaching to ground water, and runoff to surface water.
6. The Agency will not require a restricted use
classification for metolachlor end use products.
Rationale; Metolachlor is not acutely toxic
(toxicity category III) when tested via dermal, inhalation,
•oral and occular routes in rats and rabbits. Some liquid
•formulations containing metolachlor have been assigned
toxicity II on the -basis of more acutely toxic inert
ingredients. Metolachlor therefore does not met the aoute
toxicity criteria (40 CPR 162.11) for a restricted use
classification.
7. The Agency is not requiring a reentry interval
for currently registered uses of metolachlor.
Rationale; Exposure of metolachlor to field
workers is not expected to be significant since metolachlor
is incorporated prior to planting or applied after planting
to bare ground well before growth of the crop would require
entry into the treated field. Therefore, no reentry interval
is required.
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8. The Agency is imposing labeling restrictions
on rotational crops. The extent of the restrictions will be
reconsidered when additional data are submitted and reviewed.
Rationale; The Agency lacks sufficient data at
the present time to determine whether planting a crop without
existing tolerances in metolachlor-treated soil would result
in illegal residues. Existing data indicates possible uptake
into rotated crops. A 12 month planting restriction will serve
to protect the public from impermissible residues in food and
feed during the time necessary to generate and assess the data.
9. The Agency is requiring a full range of
environmental fate studies (see data tables in Appendix I).
Rationale; Available data are insufficient to
fully assess the environmental fate and transport of metolachlor.
Therefore, additional data are required.
10. The Agency is requiring the following studies
to support existing tolerances in agricultural commodities:
potato metabolism study; storage stability data; processing
studies for potatoes, soybeans, field corn, cottonseed and
peanuts; residue data on succulent and dried beans treated
-with the 25% granular metolachlor formulation.
Rationale; Metabolism in potatoes has not
been adequately defined. Storage stability has not been
completely characterized. Adequate data are not available to
describe residues in processed products. Residue data are
required with the 25% granular product to assure that applica-
tion will not exceed established tolerances in beans (dry and
succulent) and peas (dry and succulent).
11. The Agency is requiring label statements
regarding endangered species for all metolachlor products
registered for crop uses.
Rationale; Since metolachlor is a herbicide
and has crop use patterns that overlap Federally designated
endangered plant habitats, label restrictions are needed to
to afford protection to these endangered species.
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12. While data gaps are being filled, currently
registered manufacturing-use and end-use products containing
metolachlor as the sole active ingredient may be sold,
distributed, formulated, and used in the United States.
Registrants must provide or agree to develop additional data,
as specified in Tables A and B of the Data Appendix. The
Agency will issue registrations for substantially similar
products and will consider new uses on a case-by-case basis.
Rationale: Under the Federal Insecticide,
Fungicide, and Rodenticide Act (FIFRA), the Agency may determine
not to cancel or withhold registration if data are missing or
are inadequate [see FIFRA sections 3(c)(2)(B) and 3(c)(7)].
Issuance of this Standard provides a mechanism
for identifying data needs. These data will be reviewed and
evaluated and the Agency will determine if the data will
affect the registration of metolachlor.
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B. Criteria for Registration
To be registered or reregistered under this Standard,
products must contain raetolachlor as the sole active ingredient,
bear required labeling, and conform to the product composition,
acute toxicity limits, and use pattern requirements listed in
this section.
C. Acceptable Ranges and Limits
1. Product Composition Standard
To be registered or reregistered under this
Standard, manufacturing-use products (MP) must contain
metolachlor as the sole active ingredient. Each MP formulation
proposed for registration must be fully described with an
appropriate certification of limits, stating maximum and
minimum amounts of the active ingredient and inert ingredients
which are present in products, as well as impurities found at
greater than 0.1 percent.
2. Acute Toxicity Limits
The Agency will consider registration of
'technical grade and manufacturing-use products containing
'metolachlor provided that the product labeling bears appropriate
precautionary statements for the acute toxicity category in
which each product is placed.
3. Use Patterns
To be registered under this Standard,
manufacturing-use products may be labeled for formulation
into end-use herbicide products only for the commodities listed
below. The Use Index lists all registered uses, as well as
approved maximum application rates and frequencies.
- Terrestrial, nondomestic, food uses on:
beans (succulent and dry), fresh corn, grain
corn, cotton, peanuts, peas (succulent and
dry), chili peppers, potatoes, safflower,
sorghum, soybeans, stone fruits, and tree
nuts.
- Terrestrial, nondomestic, nonfood uses on:
ornamental plants, highway and railroad rights-
of-way.
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D. Required Labeling
All manufacturing-use products (and end-use products,
if covered by Standard) must bear appropriate labeling as
specified in 40 CFR 162.10. Appendix II contains information
on label requirements.
No pesticide product containing metolachlor may be
released for shipment by the registrant after 12 months after
receipt of the Standard unless the product bears an amended
label which complies with the requirements of this Standard
No pesticide product containing metolachlor may be
distributed, sold, offered for sale, held for sale, shipped,
delivered for shipment, or received and (having so received)
delivered or offered to be delivered by any person after
24 months after receipt of the Standard unless the product
bears an amended label which complies with the requirements
of this Standard
In addition to the above, the following information
must appear on the labeling:
•1. Ingredients Statement
The ingredient statement for each MP must list the
active ingredient as:
Metolachlor
2. Use Pattern Statements
All manufacturing-use products must state that
they are intended for formulation into end-use herbicide products
for acceptable use patterns. Labeling must specify sites, which
are listed in Use Patterns, Section IV.C.3. However, no use
may be included on the label where the registrant fails to agree
to comply with the data requirements in Table A for that use
pattern.
3. Precautionary Statements
Manufacturing-Use Products
Environmental Hazards
Do not discharge effluent containing
this product into lakes, streams,
ponds, estuaries, oceans, or public
water unless this product is specifi-
20
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cally identified and addressed in an
NPDES* permit. Do not discharge effluent
containing this product to sewer
systems without previously notifying
the sewage treatment plant authority.
For guidance contact your State Water
Board or Regional Office of the EPA.
End-Use Products
a. Environmental_HaZi a. rds J:j3r Emu1si fi ab 1 e
Concentrates and Flowable Concentrates
Do not apply directly to water or
wetlands (swamps, bogs, marshes, and
potholes). Do not contaminate water by
cleaning of equipment or disposal of
wastes.
b. Environmental jiazards for _Granules
Cover or incorporate granules that are
spilled during loading or are visible on
soil surface in turn areas. Do not
contaminate water by cleaning of equipment
or disposal of wastes.
c. Ground Water and Surface Water^Advisory
Metolachlor has been identified in limited
sampling of ground water and there is the
possibility that it may leach through the
soil to ground water, especially where
soils are coarse and ground water is near
the surface. "Following application and
during rainfall events that cause runoff,
metolachlor may reach surface water bodies
including streams, rivers and reservoirs.
Care must be taken when using this product
to prevent back siphoning into wells, spills
or improper disposal of excess pesticide,
spray mixtures or rinsates.
Check valves or antisiphoning devices 'nu.st
be used on all mixing and/or irrigation
equipment.
•National Pollution Discharge Elimination System
21
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<1, CVop Rotation Statement
Crops other than beans (succulent and dry),
fresh corn, grain corn, cotton, peanuts,
peas (succulent and dry), chili peppers,
potatoes, safflower, sorghum, soybeans,
stone fruits, tree nuts and barley,
buckwheat, millet, milo, oats, r'.ce, rye,
and wheat may not be planted In metolachlor-
treated soil until 12 months after application.
e. Endangered Species Statements for Products
Registered for CropJJses
It is a violation of Federal laws to use any
pesticide in a manner thai; results in the
death of endangered species or adverse
modification of their habitat.
The use of this product may pose a hazard to
certain Federally designated endangered species
known to occur in specific areas within the
CALIFORNIA counties oF Merced, Sacramento and
Solano. Before using this product in these
counties you must obtain the EPA Endangered
Species Crop Bulletin. The bulletin Is
available from either your County Agricultural
Extension Agent, the Endangered Species
Specialist in your State Wildlife Agency
Headquarters, or the Regional Office of either
the U.S. Fish and Wildlife Service (Portland,
Oregon) or the U.S. Environmental Protection
Agency (San Francisco, California). THIS
BULLETIN MUST BE REVIEWED PRIOR TO PESTICIDE
USE. THE USE OF THIS PRODUCT IS PROHIBITED
IN THESE COUNTIES UNLESS SPECIFIED OTHERWISE
IN THE BULLETIN.
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V. PRODUCTS SUBJECT TO THIS STANDARD
All products containing the pesticide identified in
Section II.A. are subject to certain requirements for data
submission or changes in composition, labeling or packaging
of the product. The applicable requirements depend on whether
the product is a manufacturing or end use product and whether
the pesticide is the sole active ingredient or one of multiple
active ingredients.
Products are subject to this Registration Standard as
follows:
A. Manufacturing use products containing this pesticide as
the sole active ingredient are subject to: 1) The restrictions
upon use, composition, or packaging listed in Section IV;
2) The data requirements listed in Tables A and B; 3) The
labeling requirements specified for manufacturing-use products
in Section IV; 4) Administrative requirements (application
forme, Confidential Statement of Formula, data compensation
provisions) associated with reregistration.!
B. End-use products containing this pesticide are subject to:
1) The labeling requirements specified for end-use products
in. Section IV; 2) If not eligible for the formulator's exemption,
the data requirements listed in Table A.2
1 Data requirements are listed in the Tables in Appendix I
of this Registration Standard. The Guide to Tables in that
Appendix explains how to read the Tables. Table A lists
generic data requirements applicable to all products containing
the pesticide subject to this Registration Standard. Table
B lists product-specific data applicable to manufacturing-use
products. The data in Tables A and B need not be submitted
by a producer who is eligible for the formulator's exemption.
2 If you purchase from another producer and use as the
source of your active ingredient only EPA-registered products,
you are eligible for the formulator's exemption for generic
data concerning that active ingredient (Table A) and product-
specific data for the registered manufacturing use product
you purchase (Table B). Two circumstances nullify this
exemption: 1) If you change sources of active ingredient to
an unregistered product, formulate your own active ingredient,
or acquire your active ingredient from a firm with ownership
in common with yours, you individually lose the exemption
and become subject to the data requirements in Table A.
2) If no producer subject to the generic data requirements
in Table A agrees to submit the required data, all end use
producers lose the exemption, and become subject to those
data requirements.
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VI. REQUIREMENT FOR SUBMISSION OF GENERIC DATA
This portion of the Registration Standard is a notice
issued under the authority of FIFRA sec. 3(c)(2)(B). It
refers to the data listed in Table A, which are required to
be submitted by registrants to maintain in effect the regis-
tration of products containing this active ingredient.3
A. What are generic data?
Generic data pertain to the properties or effects of a
particular active ingredient. Such data are relevant to an
evaluation of all products containing that active ingredient
regardless of whether the product contains other ingredients.
(unless the product bears labeling that would make the data
requirement inapplicable).
Generic data may also be data on a "typical formulation"
of a product. "Typical formulation" testing is often required
for ecological effects studies and applies to all products
having that formulation type. These are classed as generic
data, and are contained in Table A.
B. Who must submit generic data?
All current registrants are responsible for submitting
generic data in response to a data request under PIFRA sec.
3(c)(2)(B) (DCI Notice). EPA has decided, however, not to
require a registrant who qualifies for the formulator's
exemption (PIFRA sec. 3(c)(2)(D) and § 152.85) to submit
generic data in response to a DCI notice if the registrant
who supplies the active ingredient in his product is complying
with the data request.
If you are not now eligible for a forraulator's exemption,
you may qualify for one if you change your source of supply
to a registered source that does not share ownership in
common with your firm. If you choose to change sources of
supply, the Confidential Statement of Formula must Identify
the new source(s) and you must submit a Pormulator's Exemption
Statement form.
If you apply for a new registration for products containing
this active ingredient after the issuance of this Registration
Standard, you will be required to submit or cite generic
data relevant to the uses of your product if, at the time
3 Registrations granted after issuance of this Standard
will be conditioned upon submission or citation of the data
listed in this Registration Standard.
24
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the application is submitted, the data have been submitted
to the Agency by current registrants. If the required data
have not yet been submitted, any new registration will be
conditioned upon the new registrant's submission or citation
of the required data not later than the date upon which
current registrants of similar products are required to provide
such data. See PIPRA sec. 3(c)(7)(A). If you thereafter fail
to comply with the condition of that registration to provide
data, the registration may be cancelled (PIPRA sec. 6(e)).
C. What generic data must be submitted?
You may determine which generic data you must submit by
consulting Table A. That table lists the generic data needed
to evaluate current uses of all products containing this
active Ingredient, the uses for which such data are required,
and the dates by which the data must be submitted to the
Agency.
D. How to comply with PCI requirements.
Within 90 days of your receipt of this Registration
Standard, you must submit to EPA a completed copy of the form
entitled "PIPRA Section 3(c)(2)(B) Summary Sheet" (EPA Form
8580-1,.. enclosed) for each of your products. On that form
you must state which of the following six methods you will
use to comply with the DCI requirements:
1. You will submit the data, and either —
(a) Submit the existing data that you believe will
satisfy the data requirements, or
(b) State that you will secure the data or have
made a contract to have any necessary studies completed
within the applicable time period.
2. You have entered into an agreement with one or more
registrants to Jointly develop (or share In the cost of
developing) the data, but will not be submitting the data
yourself. If you use this method, you must state who will
submit the data on which you will rely. You must also provide
EPA with documentary evidence that an agreement has been
formed which allows you to rely upon the data to be submitted.
Such evidence may be: (1) your letter offering to Join in
an agreement and the other registrant's acceptance of your
offer, (2) a written statement by the parties that an agreement
exists, or (3) a written statement by the person who will be
submitting the data that you may rely upon its submission.
The Agency will also require adequate assurance that the
person whom you state will provide the data is taking appropriate
steps to secure it. The agreement to produce the data need
not specify all of the terras of the final arrangement between
the parties or a mechanism to resolve the terms.
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3. You have attempted to enter into an agreement to
Jointly develop data, but no other registrant has accepted
your offer. You request that EPA not suspend your registration
for non-compliance with the PCI. EPA has determined that,
as a general policy, it will not suspend the registration of
a product when the registrant has in good faith sought and
continues to seek to enter into a data development/cost
sharing program, but the other registrants developing the
data have refused to accept its offer. [If your offer is
accepted, you may qualify for Option 2 above by entering
into an agreement to supply the data.]
In order to qualify for this method, you must:
1. File with EPA a completed "Certification of Attempt
to Enter into an Agreement with other Registrants for Develop-
ment of Data" (EPA Form 8580-6, enclosed).
2. Provide us with a copy of your offer to the other
registrant and proof of the other registrant's receipt of your
offer (such as a certified mail receipt). Your offer must,
at a minimum, conta'ln the following language or its equivalent:
[Your company name] offers to share in the burden of
•- • producing the data required pursuant to FIFRA sec.
3(c)(2)(3) in the [name of active ingredient] Registration
Standard upon terms to be agreed or failing agreement
to be bound by binding arbitration as provided by FIFRA
section 3(c)(2)(B)(iii).
The remainder of.your offer may not in any way attempt to
limit this commitment. If the other registrant to whom your
offer is made does not accept your offer, and if the other
registrant informs us on a DCI Summary Sheet that he will
develop and submit the data required under the DCI, then you
may qualify for this option. In order for you to avoid
suspension under this method, you may not later withdraw or
limit your offer to share in the burden of developing the
data. In addition, the other registrant must fulfill its
commitment to develop and submit the data.
H. You request a waiver of the data requirement. If
you believe that a data requirement does not (or should not)
apply to your product or its uses, you must provide EPA with
a statement of the reasons why you believe this is so. Your
statement must address the specific composition or use factors
that lead you to believe that a requirement does not apply.
Since the Agency has carefully considered the composition and
uses of pesticide products In determining that a data require-
ment applies, EPA does not anticipate that many waivers will
be granted. A request for waiver does not extend the time-
frames for developing required data, and if your waiver
request is denied, your registration may be suspended If you
fail to submit the data.
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5. You request that EPA amend your registration by deleting
the uses for which the data are needed. You are not required
to submit data for uses which are no longer on your label.
6. You request voluntary cancellation of the registration
of your product(s) for which the data are needed.
E. Procedures for requesting a change in testing protocol.
If you will generate the required data and plan to use
test procedures which deviate from (or are not specified in)
either EPA's Pesticide Assessment Guidelines or the Reports
of Expert Groups to the Chemicals Group, Organization for
Economic Cooperation and Development (OECD) Chemicals Testing
Programme, you must submit for EPA approval the protocols
you propose to use.
You should submit your protocols before beginning testing
and await EPA approval, because the Agency will not ordinarily
accept as sufficient studies using unapproved protocols.
A request for protocol approval will not extend the timeframe
for submission of the data, nor will extensions generally be
given to conduct studies due to subraittal of inappropriate
protocols.
F. Procedures for requesting extensions of time.
If you think that you will need more time to generate
the data than is allowed by EPA's schedule, you may submit a
request for an extension of time. Any request for a time
extension which is made as an initial response to a section
3(c)(2)(B) request notice must be submitted in writing to
the Product Manager listed at the end of this section and
must be made before the deadline for response. Once dates
have been committed to and EPA has accepted these commitments,
any subsequent requests for a time extension must be submitted
in writing to the Office of Compliance Monitoring.
EPA will view failure to request an extension before
the response deadline as a waiver of any future claim that
there was insufficient time to submit the data. While EPA
considers your request, you must strive to meet the deadline
for submitting the data.
The extension request should state the reasons why you
believe that an extension is necessary and the steps you
have taken to meet the testing deadline. Time extensions
normally will not be granted due to problems with laboratory
capacity or adequacy of funding, since the Agency believes
that with proper planning these can be overcome. Time extensions
may be considered when Joint data development is planned,
27
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or when the Agency must approve a new or modified protocol
before the study can be begun.
A request for an extension does not automatically extend
the timefrarne for submission of the data. If EPA denies
your request for a time extension and you do not submit the
data as requested, EPA may begin proceedings to suspend the
registrations of your products.
G. Existing stocks provision upon suspension or cancellation.
The Agency has determined that if a registration is
suspended for failure to respond to a DCI request under
PIFRA sec. 3(c)(2)(B), an existing stocks provision is not
consistent with the Act. Accordingly, the Agency does not
anticipate granting permission to sell or distribute existing
stocks of suspended product except in rare circumstances.
If you believe that your product will be suspended or cancelled
and that an existing stocks provision should be granted, you
have the burden of clearly demonstrating to EPA that granting
such permission would be consistent- with the Act. The following
information must be included in any request for an existing
stocks provision:
. .... .l.vExplanation of why an existing stocks provision Is
necessary, including a statement of the quantity of
existing stocks and your estimate of the time required
for their sale or distribution; and
2. Demonstration that such a provision would be consis-
tent with the provisions of PIPRA.
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VII. REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA
Under Its DCI authority, EPA has determined that certain
product-specific data are required to maintain your registrations
in effect. Product-specific data are derived from testing
using a specific formulated product, and, unlike generic
data, generally support only the registration of that product.
All such data must be submitted by the dates specified in
this Registration Standard.
If you have a manufacturing-use product, these data are
listed In Table B. As noted earlier, the Agency has decided
that it will not routinely require product-specific data for
end use products at this time.
In order to comply with the product specific data require-
ments, you must follow the same procedures as for generic data.
See Section VI.D, E, F, and G. You should note, however, that
product chemistry data are required for every product, and the
only acceptable responses are options VI.D.I. (submit data)
or VI.D.6.(cancellation of registration).
Failure to comply with the product-specific data require-
ments for your products will result In suspension of the
product's registration.
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VIII. REQUIREMENT FOR SUBMISSION OF REVISED LABELING
PIPRA requires each product to be labeled with accurate,
complete and sufficient instructions and precautions, reflecting
the Agency's assessment of the data supporting the product
and Its uses. General labeling requirements are set out In
40 CVR 162.10 (see Appendix II - LABELING and SUMMARY). In
addition, labeling requirements specific to products containing
this pesticide are specified In Section IV.D of this Registra-
tion Standard. Applications submitted In response to this
notice must include draft labeling for Agency review.
If you fail to submit revised labeling as required,
which complies with 40 CPR 162.10 and the specific instructions
in Section IV.D., EPA may seek to cancel or suspend the
registration of your product under PIFRA sec. 6(b)(l).
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IX. INSTRUCTIONS FOR SUBMISSION
A. Manufacturing Use Products (MUPs) containing Metolachlor
as sole active ingredient.
1. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division
for each product subject to this Registration Standard:
a. The "PIPRA Section 3(c)(2)(B) Summary Sheet" (EPA
Form 8580-1), with appropriate attachments. >d
b. Confidential Statement of Formula (EPA Form 8570-4).
c. Pormulator's Exemption Statement (EPA Form ),
Jf applicable.
d. Evidence of compliance with data compensation
requirements of FIFRA sec. 3(c)(l)(D). Refer to 40 CFR
152.80-152.99.
2. Within 9 months from receipt of this document you
must submit to the Product Manager:
a. Two copies of any required product-specific data
" .(See-Table B).
b. Three copies of draft labeling, including the
container label and any associated supplemental labeling.
Labeling should be either typewritten text on 8-1/2 x 11
inch paper or a mockup of the labeling suitable for
storage in 8-1/2 x 11 files. The draft label must indicate
the intended colors of the final label, clear indication
of the front panel of the label, and the intended type
sizes of the text.
4 If on the Summary Sheet, you commit to develop the data,
present arguments that a data requirement is not applicable
or should be waived, or submit protocols or modified protocols
for Agency review, you must submit a copy of the Summary
sheet (and any supporting information) to the Office of
Compliance Monitoring (OCM), which will be monitoring the data
generated in response to this notice. This submission is in
addition to responding to the Product Manager, and should be
submitted to the OCM's Laboratory Data Integrity Program at the
address given at the end of this section. (Actual studies
are not to be submitted to OCM.) Within 90 days of a commitment
to generate data, you must submit to OCM the name and location
of the laboratory carrying out each required test, along with
the estimated starting date for testing. Additionally, you are
to send to OCM a copy of the transmittal or cover letter for each
final report submitted to the Agency. After the intial response
and the dates or protocols have been committed to and accepted
by the Agency, you must submit any subsequent request for time
extension or protocol modification to OCM.
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3. Within the times set forth in Table A, you must
submit to the Registration Division all generic data, unless
you are eligible for the formulator's exemption. If for any
reason any test is delayed or aborted so that the schedule
cannot be met, immediately notify the Product Manager and
the Office of Compliance Monitoring of the problem, the
reasons for the problem, and your proposed course of action.
B. End Use Products containing Metolachl'or alone or in
combination with other active ingredients.
1. Within 90 days from receipt of this document, you
•must submit to the Product Manager in the Registration Division:
a. PIFRA Section 3(c)(2)(B) Summary Sheet, with
appropriate attachments^ (EPA Form 8580-1).
b. Confidential Statement of Formula (EPA Form 8570-4).
c. Formulator's Exemption Statement (EPA Form ),
. if applicable.
2. Within 9 months from receipt of this document you must
submit to the Product Manager:
•• ' ..-a.. Three copies of draft labeling, including the
container label and any associated supplemental labeling.
Labeling should be either typewritten text on 8-1/2 x 11
inch paper or a mockup of the labeling suitable for
storage in 8-1/2 x 11 files. The draft labeling must
indicate the intended colors of the final label, clear
indication of the front panel of the label, and the
intended type sizes of the text. End use product labeling
must comply specifically with the instructions in Section IV
(Regulatory Position and Rationale).
C. Addresses
The required information must be submitted to the following
address:
Richard F. Mountfort, PM-23
Registration Division (TS-767C)
Office of Pesticide Programs
Environmental Protection Agency
401 M St., SW
Washington, D.C. 20460
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The address for submissions to the Office of Compliance
Monitoring is:
Laboratory Data Integrity Program
Office of Compliance Monitoring (EN-342)
Environmental Protection Agency
401 M St., SW
Washington, D.C. 20460.
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APPENDIX I
DATA APPENDICES
34
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TGUIDE-1
GUIDE TO TABLES
Tables A, B, and C contain listings of data requirements
for the pesticides covered by this Registration Standard.
Table A contains generic data requirements that apply to
the pesticide in all products, including data requirements
for which a "typical formulation" is the test substance.
Table B contains product-specific data requirements that
apply only to a manufacturing use product.
Table C contains product-specific data requirements that
apply only to an end use product.
The data tables are generally organized according to the
following format:
1. Data Requirement (Column 1). The data requirements are
listed in the order in which they appear in 40 CFR Part 158.
The reference numbers accompanying each test refer to the
test protocols set out in the Pesticide Assessment Guidelines,
which are available from the National Technical Information
Service, 5285 Port Royal Road, Springfield, VA 22161.
2. . Test Substance (Column 2). This column lists the composition
of the test substance required to be used for the test, as
follows:
TGAI = Technical grade of the active ingredient
PAI = Pure active ingredient
PAIRA = Pure active ingredient, radio labeled
TEP = Typical end use formulation
MP = Manufacturing use product
EP = End use product
Any other test substances, such as metabolites, will be
specifically named in Column 2 or in footnotes to the table.
3. Use pattern (Column 3). This column indicates the use
patterns to which the data requirement applies. Use patterns
are the same as those given in 40 CFR Part 158. The following
letter designations are used for the given use patterns:
A = Terrestrial, food
B = Terrestrial, non-food
C = Aquatic, food
D = Aquatic, non-food
E = Greenhouse, food
F = Greenhouse, non-food
G = Forestry
H = Domestic outdoor
I = Indoor
Any other designations will be defined in a footnote to the table.
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TGUIDfi-2
4. Does EPA have data? (Column 4). This column indicates one
of three answers:
YES - EPA has data in its files that completely satisfy
this data requirement. These data may be cited by
other registrants in accordance with data compensation
requirements of Part 152, Subpart E.
PARTIALLY - EPA has some data in its files, but such data
do not fully satisfy the data requirement. In some cases,
the Agency may possess data on one of two required species,
or may possess data on one. test substance but not all.
The term may also indicate: that the data available to
EPA are incomplete. In this case, when the data are
clarified, or additional details of the testing submitted
by the original data submitter, the data may be determined
to be acceptable. If this is the case, a footnote to
the table will usually say so.
NO - EPA either possesses no data which are sufficient
to fulfill the data requirement, or the data which EPA
does possess ara flawed scientifically in a manner that
cannot be remedied by clarification or additional infor-
mation.
-5. Bibliographic citation (Column 5). If the Agency has
acceptable data in its files, this column lists the identifying
number of each study. This normally is the Master Record
Identification (MRID) number, but may be a GS number if no
MRID number has been assigned. Refer to the Bibliography
Appendices for a complete citation of the study.
6. Must additional data be submitted? (Column 6). This
column indicates whether the data must be submitted to the
Agency. If column 3 indicates that the Agency already has
data, this column will usually indicate NO. If column 3
indicates that the Agency has only partial data or no data,
this column will usually indicate YES. In some cases, even
though the Agency does not have the data, EPA will not require
its submission because of the unique characteristics of the
chemical; because data on another chemical can be used to
fulfill the data requirement; or because the data requirement
has been waived or reserved. Any such unusual situations
will be explained in a footnote to the table.
7. Timeframe for submission (Column 7). If column 5 requires
that data be submitted, this column indicates when the data
are to be submitted, based on the issuance date of the Regis-
tration Standard. The timeframes are those established either
as a result of a previous Data Call-in letter, or standardized
timeframes established by PR Notice 85-5 (August 22, 1985).
3. Footnotes (at the end of each table). Self-explanatory.
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TABLE A
GENERIC DATA REQUIREMENTS; FOR METOLACHLOR
Test Use
Data Requirement Substance Pattern
§158.120 Product Chemistry
Product Identity
61-2 - Description of Beginning TGAI All
Materials and Manufacturing
Process
61-3 - Discussion of Formation of TGAI All
Impurities
Analysis and Certification of
Product Ingredients
62-1 - Preliminary Analysis TGAI All
Physical and Chemical
Characteristics
Must Additional Timeframe
Does EPA Bibliographic Data be for
Have Data?1/ Citation1/ Submitted? Submission2/
N/A N/A Yes 6 Months
N/A N/A Yes 6 Months
N/A N/A Yes 12 Months
63-2 - Color
63-3 - Physical State
63-4 - Odor
63-5 - Melting Point
63-6 - Boiling Point
TGAI
TGAI
TGAI
TGAI
TGAI
All
All
All
All
All
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Yes
Yes
Yes
No3/
Yes
6 Months
6 Months
6 Months
6 Months
37
-------
TABLE A •
GENERIC DATA REQUIREMENTS FT>R METOLACHFOR
Must Additional Timeframe
Test "se Does EPA Bibliographic Data be for
Substance Pattern Have Data?l/ Citation!/ Submitted? Submission?/
Data Requirement
S158.120 Product Chemistry (cont'd)
Physical and Chemical
Characteristics (cont'd)
63-7 - Density, Bulk Density, or
Specific Gravity
TGAI
All
N/A
N/A
Yes
6 Months
63-8
63-9
63-10
63-11
63-12
63-13
Other
64-1
- Solubility
- Vapor Pressure
- Dissociation Constant
- Octanol/Water Partition
Coefficient
- PH
- Stability
Requirements
- Submittal of Samples
TGAI or PA I
PAI
PAI
PAI
TGAI
TGAI
TGAI, PAI
All
All
All
All
All
All
all
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Yes
Yes
Yes
Yes
No*/
Yes
No
6 Months
6 Months
6 Months
6 Months
15 Months
_!/ Not applicable. Although product chemistry data have may been submitted in the past, the Agency has determined
that these data must be resubmitted for each pesticide. New requirements have been introduced and previously
submitted data must he updated. Therefore bibliographic citations for the old data are not applicable.
2/ Data must be submitted within the indicated timeframe, based on the date of the Guidance Document:
~ 6-Month Due Date August 1, 19B7.
12-Month Due Date February 1, 1988.
Due Date May 1, 1988.
_3/ Data a^pt required since technical is a liquid at rooperature. ~z p
required since technical cannot be dis™-^ —••— J
4/ Data
h water.
-------
§158.125 Residue Chemistry
171-4 - Nature of Residue
(Metabolism)
- Plants
- Livestock
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
Test
Substance
;
Does EPA ;
Have Data?
Bibliographic
Citation
Must Additional
Data be
Submitted?
Timeframe
for
Submission!/
PAIRA
Partially
00015423 00022874
00015424 00022879
00015652 00022880
00015653 00074898
00022872 00074900
00022873
PAIRA and Plant
Metabolites
Yes
00015413
00015425
00015695
00015696
00015697
00022885
00022886
00022887
00039181
00039192
00039193
171-4 - Residue Analytical Method
- Plant and Animal
Residues
TGAI & Metabolites
Yes
00015432 00016306
00015543 00039176
00015466 00111693
00015698 00125227
171-4 - Storage Stability
PAI
Partially 00015469
Yes2/
18 Months
No
No
Yes3/
24 Months
39
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
Test
Substance
Does EPA-'
Have Data?
Bibliographic
Citation
Must Additional Tlmeframe
Data be for
Submitted? Submission1/
§158.125 Residue Chemistry - (cont'd)
171-4 - Magnitude of the Residue -
Residue Studies for Each
Pood Use
- Crop Group #1 - Root and
Tuber Vegetable GroupV
o Crop 1 - Potatoes
- Crop Field Trials TEP
- Processed Food/Feed EP
- Crop Group #2 - Legume
Vegetables Group£/
o Crop 1 - Beans
(Succulent and Dried)
- Crop Field Trials TEP
o Crop 2 - Peas
(Succulent and Dried)
- Crop Field Trials TEP
Yes 00105957 00109613 No
00106191
No
Partially 00064182 00128731
Partially 00064182 00128731
Yes5/
24 Months
YesV
Yes8/
18 Months
18 Months
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
Test
Substance
Does EPA .'1
Have Data?
Bibliographic
Citation
Must Additional Timeframe
Data be for
Submitted? Submission*/
§158.125 Residue Chemistry - (cont'd)
171-4 - Magnitude of the Residue -
Residue Studies for Each
Pood Use (cont'd)
o Crop 3 - Soybeans
- Crop Field Trials
TEP
Yes
00015399
00015^00
00015401
00015402
00015403
00015404
00015405
00015406
00015407
00015408
00015409
00015410
00015411
00015540
00015541
00015542
00015706
00015719
00015721
00015722
00015723
00015725
00015735
00015736
00015737
00015760
00015761
00015762
00015763
00015764
00015765
00015766
00015767
00015768
00015769
00015770
00015771
00015772
00015773
00015774
00015777
00015778
00015779
00015780
No
41
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
Test
Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional Tlmeframe
Data be for
Submitted? Submission1/
§158.125 Residue Chemistry - (cont'd)
o Crop 3 - Soybeans - (cont'd)
- Crop Field Trials - (cont'd)
00015726
0001572?
00015728
00015729
00016248
00016427
00016604
00039174
- Processed Food/Feed EP
Crop Group #3 - Foliage of
Legume Vegetables Group
(Except Soybean Forage,
Hay and Straw)
- Crop Field Trials TEP
o Crop 1 - Soybean Forage,
Hay and Straw
- Crop Field Trials TEP
No
Yes
Yes
42
00128731
00015399
00015400
00015401
00015402
00015403
00015408
00015540
00015541
00015542
00015706
00015719
00015734
00015736
00015737
00015760
00015761
00015762
00015763
00015764
00015765
00015766
00015767
Yes9/
24 Months
No
No
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
Test
Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional Timeframe
Data be for
Submitted? Submission1/
§158.125 Residue Chemistry - (cont'd)
o Crop 1 - Soybean Forage,
Hay and Straw - (cont'd)
- Crop Field Trials - (cont'd)
- Crop Group #4 - Fruiting Vegetables
(Except Cucurbits) GrouplO/
o Crop 1 - Chili Peppers
- Crop Field Trials
TEP
Yes
00015721
00015722
00015725
00015726
00015727
00015728
00015729
00015731
00015732
00015733
00150180
00015768
00015769
00015770
00015771
00015772
00015773
00015774
00015775
00015777
00039174
No
43
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
Test
Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional Timeframe
Data be for
Submitted? Submission1/
§158.125 Residue Chemistry - (cont'd)
171-4 - Magnitude of the Residue -
Residue Studies for Each
Pood Use
- Crop Group #5 - Cereal Grains
Group11/
o Crop 1 - Corn, Field and
Fresh
- Crop Field Trials
TEP
Yes
00015*128
00015429
00015^30
00015570
00015571
00015572
00015586
00015587
00015588
00015589
00015590
00015591
00015592
00015593
00015594
00015595
00015597
00015598
00015599
00015600
00015601
00015602
00015718
00015739
00015740
00015741
00015742
00015743
00015744
00015745
00015746
00015747
00015748
00015749
00015750
00015751
00015752
00015753
00015754
00015755
00015756
00015757
00015786
00015787
No
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
Test
Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional Tlmeframe
Data be for
Submitted? Submission1/
§158.125 Residue Chemistry - (cont'd)
o Crop 1 - Corn, Field and
Fresh - (cont'd)
- Crop Field Trials - (cont'd)
00015676
00015677
00015678
00015679
00015680
00015681
00015682
00015683
00015684
00015685
00015686
00015687
00015688
00015689
00015690
00015691
00015692
00015693
00015694
00015704
00015705
00015707
00015708
00015709
00015710
000157H
00015712
00015713
00015714
00015715
00015716
00015717
00015950
00015954
00015955
00016392
00016393
00016394
00016395
00016396
00016397
00016398
00016399
00016435
00016436
00016437
00016438
00016440
00016441
00016442
00016443
00016444
00016445
00016596
00016598
00017699
00017700
00078942
00105956
00109612
00115206
00125227
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
Test
Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional Timeframe
Data be for
Submitted? Submisslonl/
§158.125 Residue Chemistry - (cont'd)
o Crop 1 - Corn, Field and
Fresh - (cont'd)
- Processed Food/Feed
o Crop 2 - Sorghum
- Crop Field Trials
- Crop Group #6 - Forage,
Fodder, Straw of Cereal
Grains Groupl3/
o Crop 1 - Com, Forage,
and Silage
- Crop Field Trials
o Crop 2 - Sorghum Forage,
Fodder, Hay, and Silage
- Crop Field Trials
Miscellaneous Commodities .
1 - Cotton
FCroo Field Trials
EP
TEP
No
Yes
TEP
Yes
TEP
Yes
TEP
xes
00015548
000155^9
00015550
00015551
00015552
00016607
00016608
00016609
00016610
00016990
00016991
00016992
00111693
.IV
-15/
00065047 OOI29G58
00065048
24 Months
No
No
No
46'
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
Test
Substance
Does EPA
Have Data?
Bibliographic
Citation
Must Additional Timeframe
Data be for
Submitted? Submission3
§158.125 Residue Chemistry - (cont'd)
o Crop 1 - Cotton - (cont'd)
- Processed Food/Feed EP
o Crop 2 - Okra
- Crop Field Trials TEP
o Crop 3 - Peanuts
- Crop Field Trials TEP
- Processed Food/Feed
o Crop 4 - Safflower
- Crop Field Trials
EP
TfiP
No
No
Yes
No
Yes
00015553 00015556
00015554 00015557
00015555
Yesl7/
00084006
No
Yesl9/
No
24 Months
Months
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
Test
Substance
Does EPA •
Have Data?
Bibliographic
Citation
Must Additional Timeframe
Data be for
Submitted? Submission1/
§158.125 Residue Chemistry - (cont'd)
171-4 - Magnitude of the Residue
- Indirect and Inadvertent
Tolerances
o Crops - Barley and Barley Fodder
and Forage, Buckwheat and Buck-
wheat Fodder and Forage, Millet
and Millet Fodder and Forage,
Milo and Mllo Fodder and Forage,
Oat and Oat Fodder and Forage,
Rice and Rice Fodder and Forage,
Rye and Rye Fodder and Forage,
and Wheat and Wheat Fodder and
.Forage
- Crop Field Trials
171-4 - Magnitude of the Residues In
Meat, Milk, Poultry, and
Eggs
TEP
TGAI or
Plant
Metabolites
Yes
Yes
00078297 No
00015'413 00022887 No
00022885 00106041
48
-------
TAB!
GENERIC DATA REQUIREMENTS FOR METOLACHTjOR
$158.125 Residue Chemistry
NOTE: All residue data requested in this Standard must he accompanied by information on the duration and
conditions of sample storage prior to residue analysis, and by data depicting the stability of
metolachlor residues under the conditions and for the time intervals specified, with the exception
of corn stored at 15 °C for up to 13 months. Exaggerated application rates may he required to obtain
detectable measurable weathered residues in or on raw agricultural commodities used for the processing
studies.
I/ Data must be submitted within the indicated timeframe, based on the date of the Guidance Document:
18-Month Due Date August 1, 1988.
24-Month Due Date February 1, 1989.
For Nature of the Residue in Plants and Magnitude of the Residue in Crops, the tijneframes for submitting
data are 18 or 24 months, as appropriate, commencing the first planting season following issuance of the
Standard. These timeframes will begin with the Spring 1987 planting season and data are due no later than
April 1989.
2/ Data must he submitted depicting the uptake, distribution, and metabolism of metolachlor in potatoes
following foliar application. Sampling intervals through at least 21 days must be included. The identities
and quantities of residue in or on mature plant parts must he determined in order to elucidate the terminal
residues. Residue identities nust be confirmed by a method such as GT, HPLC and/or mass spectrometry. Data
must also be presented that reflect the extraction efficiency of the solvent(s) used to remove residues
following application of metolachlor to living plants.
3/ Data must be submitted depicting decline over time (longer than 13 months) of levels of residues during
storage of treated commodities, under conditions (other than frozen storage at - 15 °C) used in residue tests
submitted in support of established tolerances on these commodities. Data must he submitted depicting the
stability of metolachlor in animal products (tissues, milk, and eggs). 5^>iked samples should be stored at
subfreezing temperatures for intervals approximating the storage intervals associated with treated samples
used to determine the magnitude of the residue.
4/ If food uses are sought on other members of this crop group, residue data will be required for carrot, radish,
~ and sugar beets.
5/ Data must be submitted depicting residues of concern in granules, chips, and dried potatoes processed from
~~ potato tubers bearing measurable weathered residues.
6/ If food uses are sought on other members of this crop group, residue data will he required for succulent beans,
~~ dry beans, succulent peas, and dry peas.
7/ Data must be submitted depicting residues of concern in or on succulent and dry beans following a single preplant
~~ incorporation or preemergence application of the 25% Granular (G) formulation at 3 lb active ingredient (ai)
per Acre (A). Snap bean tests must h=> conducted in MI, NY, OR, and WI. Dry bean tests must be conducted in
MI, CA, NEf CO, and ND.
49
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOI.ACHLOR
TOOTNOTES (cont'd)
§158.125 Residue Chemistry
8/ Data must be submitted depleting residues of concern- In or on succulent and dry peas from application of the
25/6 0 formulation. If submitted, data conducted with succulent and dry beans may be translated to satisfy
this requirement.
£/ Data must be submitted depleting residues of concern In meal, hulls, soapstock, crude oil, and refined oil
prepared from soybeans bearing measurable weathered residues.
10/ If food uses are sought on other members of this crop group, residue data will he required for tomatoes and
peppers.
ll/ If food uses are sought on other members of this crop group, residue data will he required for rice and wheat.
12/ Data must be submitted depleting residues of concern In crude oil, refined oil, and milled products processed
from field corn bearing measurable weathered residues.
13/ If food uses are sought on other members of this crop group, residue data will be required for wheat forage,
hay, and straw.
IV Bibliographic citation Is identical to Crop Croup #5, Crop 1 - Corn, Field and Fresh.
157 Bibliographic citation is identical to Crop Group #5, Crop 2 - Sorghum.
To7 No tolerances have been established for the raw agricultural commodity cotton forage. Cotton use directions
must continue to include feeding and grazing restrictions.
17/ Data must be submitted depicting residues of concern in hulls, meal, crude oil, refined oil, and soapstock
processed from cottonseed bearing measurable weathered residues.
18/ Okra was removed from the last accepted label for the 25% G formulation. Before it can be reinstated on the
labeling, data must be submitted depicting residues of concern In or on okra harvested at maturity following
preplant incorporation within 14 days of planting and preemergence application of this formulation at 3 lb
ai/A. Tests must be conducted in TX, GA, PL, AL, and LA , and tolerances proposed for this crop.
19/ Data must be submitted depicting residues of concern In meal, crude oil, refined oil, and soapstock processed
from peanuts bearing measurable weathered residues.
50
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOIACHLOR
Te.st Use
Data Requirement Substance Pattern
§158.130 Environmental Pate
DEGRADATION STUDIES-LAB
161-1- Hydrolysis TGAI or PAIRA
Photodegradation
161-2 - In Water TGAI or PAIRA
161-3 - On Soil TGAI or PAIRA
161-4 - In Air TGAI or PAIRA
METABOLISM STUDIES-LAB
162-1 - Aerobic Soil TGAI or PAIRA
162-2 - Anaerobic Soil TGAI or PAIRA
162-3 ~ Anaerobic Aquatic TGAI or PAIRA
162-4 - Aerobic Aquatic TGAI or PAIRA
MOBILITY STUDIES
163-1 - Leaching and TGAI or PAIRA
Adsorpt ion/Desorpt ion
163-2 - Volatility (Lab) TEP
163-3 - Volatility (Field) TEP
A,B
A,B
A
A,B
A,B
A,B
A,B
A,B
A,B
A
A
i
Does .EPA
Have Data?
No
No
Partially
No
Partially
Partially
No
No
Partially
No
No
Must Additional Timeframe
Bibliographic Data be for
Citation Submitted? Submission1/
Yes
Yes
00016301 Yes
Reserved^/
00016296 Yes
00015656 Yes
Reserved3/
YesV
00015676 00078291 Yes
00015659
Yes
Reserved^/
9 Months
9 Months
9 Months
27 Months
27 Months
27 Months
12 Months
12 Months
51
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
§158.130 Environmental Pate -
164-1 - Soil
164-2 - Aquatic (Sediment)
164-3 - Forestry
164-4 - Combination and
Test
Substance
(cont'd)
TEP
TEP
TEP
—
Use
Pattern
A
A,B
—
—
i
Does EPA Bibliographic
Have Data? Citation
No
No
N/A
N/A
Must Additional
Data be
Submitted?
Yes
Reserved3/
Tlmeframe
for
Submission!/
27 Months
Tank Mixes
164-5 - Soil, Long-Term
ACCUMULATION STUDIES
165-1 - Rotational Crops
(Confined)
165-2 - Rotational Crops
(Field)
165-3 - Irrigated Crops
165-4 - In Fish
165-5 - In Aquatic Nontarget
Organisms
ADDITIONAL STUDIES
- Ground and Surface Water
Mjg^torlng
TEP
PAIRA
TEP
TEP
TGAI or PAIRA
TEP
TfiP
A No
A Partially
A No
A,B No
A,B No
A,B No
A,B Partially 00154870
52
00015538 00022882
00022878 00022883
00022881
Reserved^/
Yes
Reserved^/
Reserved^/
Yes
Reserved^/
Yes7/
39 Months
12 Months
— Months8/
-------
TABf.F. A
GFNFRIC DATA PROUIREMtflMTS FDR MRTOLACHLDR
FOOTNOTRS
S158.130 Environmental Fate
_!/ Data must be submitted within the indicated timeframe, based on the date of the Guidance Document:
90-Day Due Date May 2, 1987.
9-Month Due Date November 1, 1987.
12-Month Dje Date February 1, 1988.
27-Month Due Date May 1, 1989.
39-Month Due Date May 1, 1990.
2/ Data will he required based on results of the lab volatility study.
3/ Data will be required hased on results of aquatic inpact studies.
4/ Required since metolachlor has been found to run off and contaminate surface water systems.
J5/ Data will be required based on results of soil metabolism and soil dissipation studies.
6/ Data will be required based on results of confined accumulation study.
7/ Studies nust be designed and conducted to determine the means and extent of metolachlor's potential to leach
to ground water and of metolachlor's potential to run off to surface water bodies and to contaminate drinking
water drawn from surface sources.
8/ Protocols must be submitted within 90 days of the date of the Guidance Document. The Agency will provide the
timeframe for submission of the final report.
53
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data
§158.
Requirement
135 Toxicology
Test Use
Substance Pattern
1
Does EPA Bibliographic
Have Data? Citation
Must Additional
Data be
Submitted?
Time frame
for
Submisslonl/
ACUTE TESTING:
81-1
81-2
81-3
81-7
- Acute Oral Toxiclty - Rat
- Acute Dermal Toxiclty
- Rabbit
- Acute Inhalation Toxiclty
- Rat
- Delayed Neurotoxlclty
- Hen
TGAI A,B
TGAI A,B
TGAI A,B
TGAI A,B
Yes 00015523
Yes 00015526
Yes 00015535
No
No
No
No
No£/
SUBCHRONIC TESTING
82-1
82-2
82-4
82-5
- 90-Day Feeding:
- Rodent, and
- Nonrodent (Dog)
- 21-Day Dermal - Rabbit
- 90-Day Inhalation - Rat
- 90-Day Neurotoxlelty
TGAI
A,B
A,B
TGAI A,B
TGAI A,B
TGAI A,B
No
Yes 00017690
00016632
No
No
No
NoV
No
NoV
No5/
No£/
54
-------
TABLE. A
GENERIC DATA REQUIREMENTS TOR METOLACHLOR
Data
§158
83-1
83-2
83-3
83-1
Requirement
.135 Toxicology - (cont'd)
- Chronic Toxlclty -
2 Species:
- Rodent, and
- Nonrodent (Dog)
- Oncogenlclty -
2 Species:
- Rat (preferred), and
- Mouse (preferred)
- Teratogenlclty -
2 Species:
- Rat
- Rabbit
- Reproduction - Rat
2-Generatlon
Test Use Does EPA Bibliographic
Substance Pattern Have Data? Citation
TGAI
A Yes 00063398
N/A
TGAI
A Yes 00015118
00063398
A Yes 00084003
00039191
TGAI
A,B Yes 00015396
A,B Yes 00011283
TGAI
A Yes 00080897
Must Additional Timeframe
Data be for
Submitted? Submissionl/
No
No
No
No
No
No
MUTAGENICITY TESTING
81-2 - Gene Mutation (Ames Test)
TGAI
A,B
Partially 00015397
Yes6/
9 Months
55
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR METOLACHLOR
Data Requirement
Test Use
Substance Pattern
noes EPA Bibliographic
Have Data? Citation
Must Additional Time frame
Data be for
Submitted? Submission!/
§158.135 Toxicology - (cont'd)
84-2 - Structural Chromosomal
Aberration
84-4 - Other Genotoxic Effects
SPECIAL TESTING
TGAI
TGAI
A,B
A,B
Partially 00015630
No
YesZ/
Yes
12 Months
12 Months
85-1
- General Metabolism
- Effects on Coagulation
PAI or PAIRA
TGAI
A
A
No
No
Yes
Yesj?/
24 Months
— Months9./
I/ Data must be submitted within the indicated tijneframe, based on the date of the Guidance Document:
6-Month Dae Date August 1, 1987.
9-Month Due Date November 1, 1987.
12-Month Due Date Feburary 1, 1988.
24-Month Due Date February 1, 1989.
2/ Data are not required since metolachlor is not an organophosphate.
V Although there is no 90-day feeding study with rodents, there is available a 2-year chronic feeding study
with rats which fills this requirement.
$/ Data are not required since existing registered uses of metolachlor should not result in repeated skin contact.
J5/ Data are not required since existing registered uses of metolachlor should not result in repeated inhalation
exposure.
6/ Additional testing is required in an j.n_ vitro mammalian cell system.
7/ Additional testing is required in a more sensitive test, system than the mouse dominant lethal test.
8/ Evaluation of the effects of metolachlor on the clotting system of the dog is required to asses the decrease
in activated partial throboplasin time (APTT) observed in the 6-month dog study.
9/ Protocols must be submitted within 6 months of the dabo of the Guidance Document. The Agency will provide
~~ the timeframft for submission of the final report.
56
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
Test Use
Substance Pattern
Does EPA Bibliographic
Have Data? Citation
Must Additional Timeframe
Data be for
Submitted? Submission
§158.1*10 Reentry Protection
132-1 - Foliar Dissipation
132-1 - Soil Dissipation
133-3 - Dermal Exposure
133-4 - Inhalation Exposure
TEP
TEP
TEP
TEP
A,B
A,B
A,B
A,B
No
No
No
No
NoV
NoV
NoV
No1/
_!/ Data are not required since the existing registered uses of metolachlor are such that no human exposure of
~ farmworkers to residues is anticipated.
57
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METOIACHLOR
Data Requirement
Test Use
Substance Pattern
Does EPA Bibliographic
Have Data? CltatIon
Must Additional Tlmeframe
Data be for
Submitted? Submission
§158.115 Wildlife and Aquatic
Organisms
AVIAN AND MAMMALIAN TESTING
71-1 - Acute Avian Oral Toxiclty TGAI A,B Yes 00062465
71-2 - Avian Subacute Dietary TGAI
Toxiclty
- Upland Game Bird, and A Yes 00016H25
- Waterfowl A Yes 00016M26
71-3 - Wild Mammal Toxlcity TGAI — N/A
71-4 - Avian Reproduction TGAI
- Upland Game Bird, and A,B Yes GS0001-001
- Waterfowl A,B Yes GS0001-002
71-5 - Slmula'jed Field Testing TEP — N/A
- Mammals, and
- Birds
- Actual Field Testing TEP ~ N/A
- Mammals, and
- Birds
No
No
No
No
No
58
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TABLE .A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data Requirement
§158.145 Wildlife and Aquatic
Organisms - (cont'd)
Test Use Does EPA Bibliographic
Substance Pattern Have Data? Citation
Must Additional
Data be
Submitted?
Timeframe
for
Submission
AQUATIC ORGANISM TESTING
72-1 - Freshwater Fish Toxicity TGAI
- Coldwater Fish Species, and
- Warmwater Fish Species
72-2 - Acute Toxicity to Freshwater TGAI
Invertebrates
72-3 - Acute Toxicity to Estuarine TGAI
and Marine Organisms
- Fish
- Mollusk
- ShrJ"ip
72-4 - Fish Early Life Stage, and TGAI
- Aquatic Invertebrate
Life Cycle
72-5 - Fish Life-Cycle TGAI
A,B
A,B
A,B
Yes
Yes
Yes
N/A
N/A
00018722
00018723
00015546
No
No
No
B
Yea
GS0001-003
No
59
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TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Data RequlrotKint
Test
Substance
Use
Pattern
i
Does EPA
Have Data?
Bibliographic
Citation
Must Additional
Data be
Submitted?
Timeframe
for
Submission
§158.145 Wildlife and Aquatic
Organisms - (cont'd)
72-6 - Aquatic Organism
Accumulation
- Crustacean
- Pish
- Insect ffymph
- Mollusk
72-7 - Simulated Field Testing
- Aquatic Organisms
Actual Field Testing
- Aquatic Organisms
TQAI, PAI or
Degradation
Product
N/A
TEP
N/A
60
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TABLE A
GENERIC DATA REQUIREMENTS FOR METOLACHLOR
Must Additional Tlmeframe
Test Use Does EPA Bibliographic Data be for
Data Requirement Substance Pattern Have Data? Citation Submitted? Submission
§158.145 Plant Protection
121-1 - TARGET AREA PHYTOTOXICITY EP — No
NONTARGET AREA PHYTOTOXICITY
TIER I
122-1 - Seed Germination/Seedling TGAI — No
Emergence
122-1 - Vegetative Vigor TGAI — No
122-2 - Aquatic Plant Growth TGAI — No
TIER II
123-1 - Seed Germination/Seedling TGAI — No
Emergence
123-1 - Vegetative Vigor TGAI — No
123-2 - Aquatic Plant Growth TGAI — No
TIER III
124-1 - Terrestrial Field TEP — No
124-2 - Aquatic Field TEP — No
NoV
NoV
NoV
NoV
NoV
NoV
NoV
NoV
NoV
_!/ These data are not required in accordance with §158.150.
61
-------
TABLE A
GENERIC DATA REQUIREMENTS;FOR METOLACHLOR
Data Requireipent
Test
Substance
Use
Pattern
Does EPA
Have Data?
Bibliographic
Citation
Must Additional
Data be
Submitted?
Timeframe
for
Submission
§158.155 Nontarget Insect
NONTARGET INSECT TESTING POLLINATORS
l - Honeybee Acute Contact TGAI — No NoV
Toxicity
- Honeybee - Toxicity of TEP — No NoV
Residues on Foliage
- Honeybee Subacute Feeding (Reserved)
Study
141-5 - Field Testing for TEP — No NoV
Pollinators
_!/ Data are not required since the registered uses of metolachlor will not result in exposure to honeybees.
62
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TABLE. B
PRODUCT-SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING METOLACHLOR
Test
Data Requirement Substance
§158.120 Product Chemistry
Product Identity
61-1 - Product Identity and MP
Disclosure of Ingredients
61-2 - Description of Beginning MP
Materials and Manufacturing
Process
61-3 - Discussion of Formation of MP
Impurities
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis MP
62-2 - Certification of Limits MP
62-3 - Analytical Methods to Verify MP
Certified Limit
Physical and Chemical Characteristics
63-2 - Color MP
63-3 - Physical State MP
63-4 - Odor MP
Use
Pattern
All
All
All
All
All
All
All
All
All
Must Additional 2/Tlmeframe
Does. EPA Bibliographic Data be for
Have Data?1/ Citation1/ Submitted? Submission
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
6 Months
6 Months
6 Months
12 Months
12 Months
12 Months
6 Months
6 Months
6 Months
63
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TABLE B
PRODUCT-SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING METOLACHLOR
Test
Data Requirement Substance
§158.
120 Product Chemistry - (cont'd)
Use
Pattern
Must Additional 2/Time frame
Does EPA Bibliographic Data be for
Have Data?!/ Citationl/ Submitted? Submission
Physical and Chemical Characteristics
(cont
63-7
63-12
63-14
63-15
63-16
63-17
63-18
63-19
63-20
Other
61-1
'd)
- Density, Bulk Density, or
Specific Gravity
- pH
- Oxidizing or Reducing Action
- Flamnability
- Explodability
- Storage Stability
- Viscosity
- Miscibility
- Corrosion Characteristics
Requirements
- Submit tal of Samples
MP -
MP
MP
MP
MP
MP
MP
MP
MP
MP
All
All
All
All
All
All
All
All
All
All
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Yes
No3/
Yes
Yes
Yes
Yes
Yes
NqV
Yes
No
6 Months
6 Months
6 Months
6 Months
15 Months
6 Months
6 Months
64
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TABLE R
PRODUCT-SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONrAINING METOLACHLOR
FOOTNOTES •
l
§158.120 Product Chemistry '\
I/ Not applicable. Although product chemistry data may have been submitted in the past, the Agency has determined
that these data must he resuhmitted for each manufacturing-use product. New requirements have been introduced and
previously submitted data must be updated. Therefore bibliographic citations for the old data are not applicable.
2/ Data must be submitted within the indicated timeframe, based on the date of the Guidance Document:
6-Month Due Date August 1, 19R7.
12-MDnth Due Date February 1, 1988.
15-Month Due Date May I, 1988.
3/ Data are not required since technical grade Manufacturing-Use Product cannot he dispersed with water.
j4/ Data are not required since technical grade Manufacturing-rise Product is not an emulsifiable concentrate.
65
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TABLE B ,
PRODUCT-SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING METOLACHLOR
Data Requirement
Test Use Does EPA Bibliographic
Substance Pattern Have Data? Citation
Must Additional Tlmeframe
Data be for
Submitted? Submission
§158.135 Toxicology
ACUTE TESTING
81-1 - Acute Oral Toxiclty - Rat
81-2 - Acute Dermal Toxicity
- Rabbit
81-3 - Acute Inhalation Toxicity
- Rat
8l-4 - Primary Eye
- Irritation - Rabbit
8l-5 - Primary Dermal
- Irritation - Rabbit
8l-6 - Dermal Sensitization -
Guinea Pig
MP
MP
All
All
Yes
Yes
00015523
00015526
No
No
MP
MP
MP
MP
All
All
All
All
Yes
Yes
Yes
Yes
00015535
00015526
00015530
00015631
No
No
No
No
66
-------
APPENDIX II
LABELING APPENDICES
67
-------
SUMMARY-1
LABEL CONTENTS
40 CFR 162.10 requires that certain specific labeling
statements appear at certain locations on the label. This
is referred to as format labeling. Specific label items listed
below are keyed to the table at the end of this Appendix.
Item 1. PRODUCT NAME - The name, brand or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading.
Item 2. COMPANY NAME AND ADDRESS - The name and address
of the registrant or distributor is required on the label.
The name and address should preferably be located at the
bottom of the front panel or at the end of the label text.
Item 3. NET CONTENTS - A net contents statement is
required on all labels or on the container of the pesticide.
The preferred location is the bottom of the front panel
immediately above the company name and address, or at the end
of the label text. The net contents must be expressed in the
largest suitable unit, e.g., "1 pound 10 ounces" rather than
."2.6. ounces." In addition to English units, net contents may
be expressed in metric units. [40 CFR 162.10(d)]
Item 4. EPA REGISTRATION NUMBER - The registration
number assigned to the pesticide product must appear.on the
label, preceded by the phrase "EPA Registration No.," or "EPA
Reg. No." The registration number must be set in type of a
size and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
registration number and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency.
[40 CFR 162.10(e)]
Item 5. EPA ESTABLISHMENT NUMBER - The EPA establishment
number, preceded by the phrase "EPA Est." is the final estab-
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment number on the immediate
container cannot be clearly read through such wrapper or container.
[40 CFR 162.10(f)]
Item 6A. INGREDIENTS STATEMENT - An ingredients statement
is required on the front panel. The ingredients statement must
contain the name and percentage by weight of each active ingredient
and the total percentage by weight of all inert ingredients.
The preferred location is immediately below the product name.
The ingredients statement must run parallel with, and be clearly
distinguished from, other text on the panel. It must not be
placed in the body of other te$tr» r [40 CFR 162.10(g)]
-------
SUMMARY-2
Item 6B. POUNDS PER GALLON STATEMENT - For liquid agricul-
tural formulations, the pounds per gallon of active ingredient
must be indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS - Front panel
precautionary statements must be grouped together, preferably
within a block outline. The table below shows the minimum type
size requirements for various size labels.
Size of Label Signal Word "Keep Out of Reach
on Front Panel Minimum Type Size of Children"
in Square Inches All Capitals Minimum Type Size
5 and under 6 point 6 point
above 5 to 10 10 point 6 point
above 10 to 15 12 point 8 point
above 15 to 30 14 point 10 point
over 30 18 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT - The statement
"Keep Out of Reach of Children" must be located on the front
panel above the signal word except where contact with children
during distribution or use is unlikely. [40 CFR 162 ,10(h)(1)(ii)
-- - Item 7B. SIGNAL WORD - The signal word (DANGER, WARNING, '
or CAUTION) is required on the front panel immediately below
the child hazard warning statement. [40 CFR 162.10 (h)(l)(i)]
Item 7C. SKULL & CROSSBONES AND WORD "POISON" - On products
assigned a toxicity Category I on the basis of oral, dermal,
or inhalation toxicity, the word "Poison" shall appear on the
label in red on a background of distinctly contrasting color and
the skull and crossbones shall appear in immediate proximity to
the word POISON. [40 CFR 162.10 (h) (1) ( i)]
Item 7D. STATEMENT OF PRACTICAL TREATMENT - A Statement
of practical treatment (first aid or other) shall appear on
the label of pesticide products in toxicity Categories I,
II, and ill. [40 CFR 162.10(h)(1)(iii) ]
Item 7E. REFERRAL STATEMENT - The statement "See Side
(or Back) Panel for Additional Precautionary Statements" is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
[40 CFR 162.10(h)(l)(iii)]
Item 8 . SIDE/BACK PANEL PRECAUTIONARY LABELING - The
precautionary statements listed below must appear together
on the label under the heading "PRECAUTIONARY STATEMENTS."
The preferred location is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline. Each
of the three hazard warning statements must be headed by the
appropriate hazard title. [40 CFR 162.10(h) ( 2) ] .
69
-------
SUMMARY-3
Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS - Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions to be taken to avoid
accident, injury or damage. [40 CFR 162 ,10(h)(2)(i)]
Item 8B. ENVIRONMENTAL HAZARD - Where a hazard exists to
non-target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage. [40 CFR 162.10(h)(2)(ii)]
Item 8C. PHYSICAL OR CHEMICAL HAZARD - FLAMMABILITY
Precautionary statements relating to flammability of a product
are required to appear on the label if it meets the criteria
in the PHYS/CHEM Labeling Appendix. The requirement is
based on the results of the flashpoint determinations and
flame extension tests required to be submitted for all products.
These statements are to be located in the side/back panel
precautionary statements section, preceded by the heading
"Physical/Chemical Hazards." Note that no signal word is
used in conjunction with the flammability statements.
Item 9A. RESTRICTED USE CLASSIFICATION - FIFRA sec. 3(d)
•requir.e.s that all pesticide formulations/uses be classified
for' either 'general or restricted use. Products classified
for restricted use may be limited to use by> certified applicators
or persons under their direct supervision (or may be subject
to other restrictions that may be imposed by regulation).
In the Registration Standard, the Agency has (1) indicated
certain formulations/uses are to be restricted (Section III
indicates why the product has been classified for restricted
use); or (2) reserved any classification decision until
appropriate data are submitted.
The Regulatory Position and Rationale states whether
products containing this active ingredient are classified
for restricted use. If they are restricted the draft label(s)
submitted to the Agency as part of your application must
reflect this determination (see below).
If you do not believe that your product should be classified
for restricted use, you must submit any information and
rationale with your application for reregistration. During
the Agency's review of your application, your proposed classi-
fication determination will be evaluated in accordance with
the provisions of 40 CFR 162.11(c). You will be notified of
the Agency's classification decision.
70
-------
SUMMARY-4
Classification Labeling Requirements
If your product has been classified for restricted use,
the following label requirements apply:
1. All uses restricted.
a. The statement "Restricted Use Pesticide" must
appear at the top of the front panel of the label. The
statement must be set in type of the same minimum size
as required for human hazard signal word (see table in 40
CFR 162.10(h)(1)(iv)
b. Directly below this statement on the front panel,
a summary statement of the terms of restriction must
appear (including the reasons for restriction if specified
in Section I). If use is restricted to certified applicators,
the following statement is required: "For retail sale
to and use only by Certified Applicators or persons
under their direct supervision and only for those uses
covered by the Certified Applicator's Certification."
2. Some but not all uses restricted. If the Regulatory
position and Rationale states that some uses are classified
for restricted use, and some are unclassified, several courses
•of action are available:
a. You may label the product for Restricted use.
If you do so, you may include on the label uses that
are unrestricted, but you may not distinguish them
on the label as being unrestricted.
b. You may delete all restricted uses from your
label and submit draft labeling bearing only unrestricted
uses.
c. You may "split" your registration, i.e., register
two separate products with identical formulations, one
bearing only unrestricted uses, and the other bearing
restricted uses. To do so, submit two applications for
reregistration, each containing all forms and necessary
labels. Both applications should be submitted simul-
taneously. Note that the products will be assigned
separate registration numbers.
Item 9B [There is no Item 9B].
Item 9C. MISUSE STATEMENT - All products must bear the
misuse statement, "It is a violation of Federal law to use
this product in a manner inconsistent with its labeling."
This statement appears at the beginning of the directions
for use, directly beneath the heading of that section.
71
-------
SUMMARY-5
Item 10A. REENTRY STATEMENT - If a reentry interval
has been established by the Agency, it must be included on
the label. Additional worker protection statements may be
required in accordance with PR Notice 83-2, March 29, 1983.
Item 10B [There is no Item 10B].
Item IOC. STORAGE AND DISPOSAL BLOCK - All labels are
required to bear storage and disposal statements. These
statements are developed for specific containers, sizes, and
chemical content. These instructions must be grouped and
appear under the heading "Storage and Disposal" in the directions
for use. This heading must be set in the same type sizes as
required for the child hazard warning. Refer to Appendix II,
STOR, PEST/DIS, and CONT/DIS to determine the storage and
disposal instructions appropriate for your products.
Item 10D. DIRECTIONS FOR USE - Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. When followed, directions must be adequate to
protect the public from fraud and from personal injury and to
prevent unreasonable adverse effects on the environment.
[40 CFR 162.10]
COLLATERAL LABELING
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, or other written or graphic printed matter which is
referred to on the label or which is to accompany the product
are termed collateral labeling. Such labeling may not bear
claims or representations that differ in substance from those
accepted in connection with registration of the product. It
should be made part of the response.to this notice and submitted
for review.
72
-------
SUMMARY-6
LABELING REQUIREMENTS OF THE PIFRA, A3 AMENDED
ITEM
1
2
3
4
5
6A
6B
7
7A
7B
LABEL ELEMENT
Product name
Company name
and address
Net contents
EPA Reg. No.
EPA Est. No.
Ingredients
statement
Pounds/gallon
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where dosage
given as Ibs.
ai/unit area
All products
All products
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
None
None
None
None
Front panel
Front panel
Front panel
Front panel
Front panel
PREFERRED
Center front
panel
Bottom front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel,
immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the main
ingredients
statement
Above signal
word
Immediii to ly
below child
hazard
warning
COMMENTS
If registrant is not the producer, must
be qualified by "Packed for . . . ,"
"Distributed by. . .," etc.
May be in metric units in addition to
U.S. units
Must be in similar type size and run
parallel to other type.
May appear on the container instead of
the lahol.
Text must run parallel with other text
on the panel.
All front panel precautionary statements
must l>3 grouped together, preferably
blocked.
Note type size requirements.
Note type size requirements.
73
-------
SUMMARY-7
ITEM
7C
7D
7E
8
8A
SB
LABEL ELEMENT
Skull & cross-
bones and word
POISON (in red)
Statement of
practical
treatment
Referral
statement
Side/back panel
precautionary
statements
Hazards to
humans ami
domestic
animals
Environmental
hazards
APPLICABILITY
OF REQUIREMENT
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxic ity
All products
in Categories
I, II, and III
All products
where pre-
cautionary
late ling
appears on
other than
front panel.
All products
All products
in Categories
I, il, and in
All products
PLACEMENT ONI LABEL
REQUIRED
Front panel
Category I:
Front panel
unless refer-
ral statement
is used.
Others :
Grouped with
side panel
precautionary
statements.
Front panel
None
None
None
PREFERRED
Both in close
proximity to
signal word
Front panel
for all.
Top or side
of back panel
preced i ng
directions
for use
Same as above
Same as aliovo
COMMENTS
Must be grouped under the headings in
8A, 8B, and 8C; preferably blocked.
Must be preceded by appropriate signal
word .
Environmental hazards include bee
caution where applicable. ^^
74
-------
SUMMARY-8
ITEM
8C
9A
9C
10A
IOC
10D
LABEL ELEMENT
Physical or
chemical
hazards
Restricted
block
Misuse
statement
Reentry
statement
Storage and
disposal block
Directions
for use
APPLICABILITY
OF REQUIREMENT
All pressurized
products, others
with flash
points under
150°F
All restricted
products
All products
All
chol inesterase
inhibitors
All products
All products
PLACEMENT ON LABEL
REQUIRED
None
Top center
of front
panel
Immediately
following
heading of
directions
for use
In the
directions
for use
In the
directions
for use
None
PREFERRED
Same as above
Preferably
blocked
Immediately
after misuse
statement
fmmed lately
before
specific
directions
for use or
at the end of
directions
for use
None
COMMENTS
Includes a statement of the terms of
restriction. The words "RESTRICTED USE
PESTICIDE" must be same type size as
signal word.
Must be sot apart and clearly distin-
guishable from from other directions
for use.
May be in metric as well as U.S. units
75
-------
Criteria
PHYS/CHEM-1
PHYSICAL/CHEMICAL HAZARDS
Required Label Statement
II
Pressurized Containers
A. Flashpoint at or below
208F; or if there is a
flashback at any valve
opening.
B. Flashpoint above 20°F
and not over 80°F; or
if the flame extension
is more than 18 inches
long at a distance of
• 6 inches from the
valve opening.
C. All Other Pressurized
. -.....-Containers
Non-Pressurized Containers
. Flashpoint at or below
20°F.
B. Flashpoint above 20°F
and not over 80°F.
C. Flashpoint over 80°F
and not over 150°F.
D. Flashpoint above
150°F.
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame. Do
not puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
76
-------
STOR-1
STORAGE INSTRUCTIONS FOR PESTICIDES
Heading;
All products are required to bear specific label instructions
about storage and disposal. Storage and disposal instructions
must be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need not include the heading
"STORAGE AND DISPOSAL."
Storage Instructions;
All product labels are required to have appropriate storage
instructions. Specific storage instructions are not prescribed.
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors;
1. Conditions of storage that might alter the composition or
usefulness of the pesticide. Examples could be temperature
extremes, excessive moisture or humidity, heat, sunlight,
friction, or contaminating substances .or media.
2. Physical requirements of storage which might adversely
affect the container of the product and its ability to
continue to function properly. Requirements might include
positioning of the container in storage, storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
3. Specifications for handling the pesticide container,
including movement of container within the storage area,
proper opening and closing procedures (particularly for
opened containers), and measures to minimize exposure
while opening or closing container.
4. Instructions on what to do if the container is damaged in
any way, or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs
5. General precautions concerning locked storage, storage in
original container only, and separation of pesticides
during storage to prevent cross-contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original container and placement in
locked storage areas.
77
-------
CONT/DIS-1
CONTAINER DISPOSAL INSTRUCTIONS
The label of each product must bear container disposal
instructions appropriate to the type of container.
1. Domestic use products must bear one of the following
container disposal statements:
Container Type
Statement
Non-aerosol products
(bottles, cans, jars)
Non-aerosol products
(bags)
Aerosol products
Do not reuse container (bottle, can, jar). j
Rinse thoroughly before discarding in trash.
Do not reuse bag. Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or puncture.
2. All other products must bear container disposal instructions,
based on container type, listed below:
Container Type
Statement
Metal
containers
(non-aerosol)
Plastic containers
Triple rinse (or
for recycling or
and dispose of in
other procedures
authorities.
equivalent) . Then offer
reconditioning, or puncture
a sanitary landfill, or by
approved by state and local
Triple rinse (or
for recycling or
and dispose of in
incineration, or,
local authorities
stay out of smoke
equivalent). Then offer
reconditioning, or punctu!
a sanitary landfill, or
if allowed by state and
by burning. If burned,
Glass containers
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved state and local procedures.
Fiber drums
with liners
Completely empty liner by shaking and
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reused1, dispose of in the same manner.
Paper and
plastic bags
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out of smoke.
Compressed gas
cylinders
Return empty cylinder for reuse (or
similar wording)
I/ Manufacturer may replace this phrase with one indicating
whether and how fiber drum may be reused.
78
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PEST/DIS-1
PESTICIDE DISPOSAL INSTRUCTIONS
The label of all products, except those intended solely for domestic
use, must bear explicit instructions about pesticide disposal. The
statements listed below contain the exact wording that must appear on
the label of these products:
1. The labels of all products, except domestic use, must contain the
statement, "Do not contaminate water, food, or feed by storage or disposal."
2. Except those products intended solely for domestic use, the labels
of all products that contain active ingredients that are Acute Hazardous
Wastes (see list in this Appendix) or are assigned to Toxicity-Category
I on the basis of oral or dermal toxicity, skin or eye irritation potential,
or Toxicity Category I or II on the basis of acute inhalation toxicity
must bear the following pesticide disposal statement:
"Pesticide wastes are acutely hazardous. Improper disposal of
excess pesticide, spray mixture, or rinsate is a violation of Federal
Law. If these wastes cannot be disposed of by use according to
label instructions, contact your State Pesticide or Environmental
Control Agency, or the Hazardous Waste representative at the nearest
EPA Regional Office for guidance."
-3.- The labels of all products; except those intended for domestic use,
•containing, active or inert ingredients that are Toxic Hazardous Wastes
(see list in this Appendix) or meet any of the criteria in 40 CFR 261,
Subpart C for a hazardous waste must bear the following pesticide disposal
statement:
"Pesticide wastes are toxic. Improper disposal of excess pesticide,
spray mixture, or rinsate is a violation of Federal Law. if these
wastes cannot be disposed of by use according to label instructions,
contact your State Pesticide or Environmental Control Agency, or the
Hazardous Waste representative at the nearest EPA Regional Office
for guidance."
4. Labels for all other products, except those intended for domestic
use, must bear the following pesticide disposal statement:
"Wastes resulting from the use of this product may be disposed of on
site or at an approved waste disposal facility."
5. Products intended for domestic use only must bear the following
disposal statement: "Securely wrap original container in several layers
of newspaper and discard in trash."
79
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PEST/DIS-2
P003
P070
P004
POOS
P006
POOS
P010
P011
P012
P021
P022
P024
P030
P031
P037
P039
P040
107-13-1
116-06-3
309-00-2
107-18-6
1302-45-0
504-24-5
7778-39-4
1303-28-2
1327-53-3
592-01-8
75-15-0
106-47-8
506-77-4
60-57-1
298-04-4
297-97-2
PESTICIDE ACTIVE INGREDIENTS THAT ARE ACUTE HAZARDOUS WASTES
I. PESTICIDES ON THE "E" LIST (with RCRA t and CAS »
[40 CFR 261.33(e)]
Acrolein
Aldicarb
Aldrin
Allyl alcohol
Aluminum phosphide
4-Aninopyridine (Avitrol)
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p-Chloroaniline
Cyanides (soluble cyanide salts
not otherwise specified)
Cyanogen chloride
Dieldrin
0,0-Diethyl S-[2-ethyIthio)ethyl]
phosphorodithioate (disulfoton)
0,0-Diethyl O-pyrazinyl
phosphorothioate (Z inophos®)
Di-Tiethpate:- ••-
0,6-Dimethyi 0-p-nitrophenyl
phosphorothioate (methyl parathion)
4,6-Dinitro-o-cresol and salts
4,6-Dinitro-o-cyclohexylphenol
Dinoseb
Endosulfan
Endothall
Endrin
Famphur
Fluoroacetamide
Heptachlor
Hexachlorohexahydro-exo,exo-
d imethanonaphthalene (Isodrin)
Hydrocyanic acid
Methonyl
alpha-Naphthylthiourea (ANTU)
Nicotine and salts
Oc tame thylpyrophosphoramide
(OMPA, schradan)
Parathion
phenylmercuric acetate (PMA)
Phorate
Potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
P044
P071
P047
P034
P020
P050
P088
P051
P097
P057
P059
P069
P063
P066
P072
P075
P085
P089
P092
P094
P098
P102
P105
P106
P058
60-51-5
298-00-0
534-52-1
131-89-5
88-85-7
115-29-7
129-67-9
72-20-8
52-85-7
640-19-7
76-48-8
465-73-6
74-90-8
16752-77-5
86-88-41
54-11-5
152-16-9
56-38-2
62-38-4
298-02-2
151-50-8
107-19-7
26628-22-8
143-33-9
62-74-8
-------
PEST/DIS-3
Strychnine and salts P108 57-24-9
60-41-3
0,0,0,0-Tetraethyl P109 3689-24-5
dithiopyrophosphate (sulfotepp)
Tetraethyl pyrophosphate Pill 107-49-3
Thallium sulfate P115 7446-18-6
Thiofanox P045 39196-18-4
Toxaphene P123 8001-35-2
Warfarin (>0.3%) P001 81-81-2
Zinc phosphide (>10%) P122 1314-84-7
50 ACTIVES
F027
F027
F027
F027
F027
5324-22-1
35109-57-0
136-25-4
327-98-0
70-30-4
II. PESTICIDES DERIVED FROM TRI-, TETRA-, AND PENTACHLOROPHENOLS
[40 CFR 261.31]
2-Chloroethyl 2-(2,4,6-trichloro-
phenoxy) ethyl ether
Dehydroabietylannnoniun
pentachlorophenoxide
Erbon
O-ethyl O-(2,4 ,5-trichlorophenyl)
- -ethylphpsphonothioate
2,2l-Methyienebis
(3,4,6-trichlorophenol)
{Hexachlorophene)
—Potassium salt of
—Sodium salt of
—Disodium salt of
Pentachlorophenol
—Potassium salt of
—Sodium salt of
—Zinc salt of
—Zinc salt of N-alkyl
(Cig-Cis)-l,3-propanediamine
—Pentachlorophenyl laurate
Potassium trichlorophenate (2,4,6)
Potassium trichlorophenate (2,4,5)
Silvex
—2-Butoxyethyl ester
—Butoxypolypropoxypropyl ester
—Butoxypropyl ester
—Diethanolamine salt
—Diisopropanolamine salt
—Dimethylamine salt
—Dipropylene glycol isobutyl
ether ester
—Ethanolamine salt
—2-Ethylhexyl ester
—Isooctyl ester
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
F027
67923-62-0
3247-34-5
5736-15-2
87-86-5
7778-73-6
131-52-2
2917-32-0
3772-94-9
2591-21-1
35471-43-3
93-72-1
19398-13-1
53404-07-2
25537-26-2
51170-59-3
53404-09-4
55617-85-1
53535-26-5
7374-47-2
53404-76-5
53404-14-1
81
-------
PEST/DIS-4
—Isopropanolamine salt F027 53404-13-0
—Monohydroxylaluminum salt F027 69622-82-8
—Polypropoxypropyl ester F027 83562-66-7
—Potassium salt F027 2818-16-8
—Propylene glycol isobutyl F027 53466-84-5
ether ester
—Sodium salt F027 37913-89-6
—Triethanolamine salt F027 17369-89-0
—Triethylamine salt F027 53404-74-3
—Triisopropanolamine salt F027 53404-75-4
—Tripropylene glycol isobutyl F027 53535-30-1
ether ester
Sodium 2-(2,4,5-trichlorophenoxy) F027 3570-61-4
ethyl sulfate
Tetrachlorophenols F027 25167-83-3
—Alkylamine*amine salt (as in F027
fatty acids of coconut oil)
—Potassium salt F027 53535-27-6
—Sodium salt F027 25567-55-9
2,4,5-Trichlorophenol . F027 95-95-4
2,4,6-Trichlorcphenol F027 88-06-2
2,4,5-Trichlorophenol salt of F027 53404-83-4
" 2,6.-bis[(dimethylamino)methyl]
'."' cyclohexanone
2,4,5-Trichlorophenol, sodium salt F027 136-32-3
2,4,6-Trichlorophenol, sodium salt F027 3784-03-0
2,4,5-Trichlorophenoxyacetic acid F027 93-79-8
—Alkyl C-12 amine salt F027 53404-84-5
—Alkyl C-13 amine salt F027 53404-85-6
—Alkyl C-14 amine salt F027 53535-37-8
—N,N-diethylethanolamine salt F027 53404-86-7
—Dimethylamine salt F027 6369-97-7
—N,N-dimethyllinoleylamine salt F027 53404-88-9
—N,N-dimethyloleylamine salt F027 53404-89-0
—N-oleyl-l,3-propylene F027 53404-87-8
diamine salt
—Sodium salt F027 13560-99-1
—Triethanolamine salt F027 3813-14-7
—Triethylamine salt F027 2008-46-0
—Alkyl (C3H7 - C7H9) ester F027
—Amyl ester F027 120-39-8
—Butoxyethoxypropyl ester F027 1928-58-1
—2-Butoxyethyl ester F027 2545-59-7
—Butoxypropyl ester F027 1928-48-9
—Butyl ester F027 93-79-8
—Dipropylene glycol isobutyl F027 53535-31-2
ether ester
—2-Ethylhexyl ester F027 1928-47-8
—Isobutyl ester F027 4938-72-1
82
-------
PEST/DIS-5
—Isopropyl ester F027 93-78-7
—Propylene glycol isobutyl F027 53466-86-7
ether ester
—Tripropylene glycol isobutyl F027 53535-32-3
ether ester
4-(2,4,5-Trichlorophenoxy)butyric F027 93-80-1
acid [2,4,5-TB]
2-(2,4,5-Trichlorophenoxy)ethyl F027 69633-04-1
hydrogen sulfate [2,4,5-TES]
1,4',5'-Trichloro-2'-(2,4,5- F027 69462-14-2
trichlorophenoxy)
methanesulfonanilide [Edolan U]
83
-------
PEST/DIS-6
PESTICIDES THAT ARE TOXIC HAZARDOUS WASTES
PESTICIDES ON THE "F" LIST (with
[40 CFR 261.33(f)]
Acetone •
Acrylonitrile*
Amitrole
Benzene*
Bis( 2-ethylhexyl ) phthalate
Cacodylic acid
Carbon tetrachloride*
Chloral (hydrate)
( chloroacetaldehyde )
Chlordane, technical*
Chlorobenzene*
4 -Chi oro-m-c reso 1
Chloroform*
o-Chlorophenol
Creosote
Cresylic. acid (cresols)*
Cyclohexane
Cyclohexanone
Decachlorooctahydro-1 ,3 ,4-metheno-
2H-cyclobuta[c ,d] -pentalen-2-one
(Kepone, chlordecone)
1 , 2-Dibromo-3-chloropropane ( DBCP )
Dibutyl phthalate
S-2 ,3-( Dichloroallyl diisopropyl-
thiocarbamate ) (diallate,Avadex)
o-Dichlorobenzene*
p-Dichlorobenzene*
Di chlorod i fluorcme thane
(Freon 12®)
3 ,5-Dichloro-N-( 1 , l-dimethyl-2-
propynyl) benzamide
(pronamide, Kerb8)
Dichloro diphenyl dichloroethane
(DDD)
Dichloro diphenyl trichloroe thane
(DDT)
Dichloroethyl ether
2 ,4-Dichlorophenoxyacet ic ,
salts and esters (2,4-D)*
1 ,2-Dichlorqpropane
1 , 3-Dichloropropene ( Telone )
Dimethyl phthalate
Epichlorohydrin
( l-chloro-2 , 3-epoxypropane )
Ethyl acetate
Ethyl 4,4'-dichlorobenzilate
( chlorobenzilate )
RCRA #,
U002
U009
U011
U019
U028
U136
U211
U034
U036
U037
U039
U044
U048
U051
U052
U056
U057
U142
U066
U069
U062
U070
U072
U075
U192
U060
U061
U025
U240
U083
U084
U102
U041
U112
U038
and CAS #
67-64-1
107-13-1
61-82-5
71-43-2
117-81-7
75-60-5
56-23-5
302-17-0
57-74-9
108-90-7
59-50-7
67-66-3
95-57-8
8021-39-4
1319-77-3
110-82-7
108-94-1
143-50-0
96-12-8
84-74-2
2303-16-4
95-50-1
106-46-7
75-71-8
23950-58-5
72-54-8
50-29-3
1191-17-9
94-75-7
8003-19-8
542-75-6
131-11-3
106-89-8
141-78-6
510-15-6
*Proposed for deletion by TCLP proposal
84
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PEST/DIS-7
Ethylene dibromide (EDB)
Ethylene dichloride*
Ethylene oxide
Formaldehyde
Furfural
Hexachlorobenzene*
Hexachlorocyclopentadiene
Hexachloroethane*
Hydrofluoric acid
Isobutyl alcohol*
Lead acetate
Lindane*
Maleic hydrazide
Mercury
Methoxychlor*
Methyl alcohol (methanol)
Methyl bromide
Methyl chloride
2,2' -Methylenebis
(3,4,6-trichlorophenol)
(hexachlorophene)
[acute waste per 261.31]
Methylene chloride*
Methyl ethyl ketone*
4-Methyl-2-pentanone
.- - (methyl isobutyl ketone)
•Naphthalene
Nitrobenzene*
p-Nitrophenol
Pentachloroethane
Pentachloronitrobenzene (PCNB)
Pentachlorophenol*
[acute waste per 261.31]
Phenol*
Pyridine*
Resorcinol
Safrole
Selenium disulfide
Silvex [acute waste per 261.31]
1,1,2,2-Tetrachloroethane*
Tetrachloroethylene*
2,3,4,6-Tetrachlorophenol*
[acute waste per 261.31]
Thiram
Toluene*
1,1,1-Trichloroethane*
(methyl chloroform)
Trichloroethylene*
Trichloromonofluoromethane
(Freon 11®)
2,4,5-Trichlorophenol*
[acute waste per 261.31]
2,4,6-Trichlorophenol*
[acute waste per 261.31]
U067
U077
U115
U122
U125
U127
U130
U131
U134
U140
U144
U129
U148
U151
U247
U154
U029
U045
U132
106-93-4
107-06-2
75-21-8
50-00-0
98-01-1
118-74-1
77-47-4
67-72-1
7664-39-3
78-83-1
301-04-2
5d-39-9
123-33-1
7439-97-6
72-43-5
67-56-1
74-83-9
74-37-3
70-30-4
U080
U159
U161
U165
U169
U170
U184
U185
U242
U188
U196
U201
U203
U205
U233
U209
U210
U212
U244
U220
U226
U228
U121
U230
U23L
75-09-2
78-93-3
108-10-1
91-20-3
98-95-3
100-02-7
76-01-7
82-68-8
87-86-5
108-95-2
110-86-1
108-46-3
94-59-7
7488-56-4
93-72-1
79-34-5
127-18-4
137-26-8
108-88-3
71-55-6
79-01-6
75-69-4
95-95-4
88-06-2
85
-------
PEST/DIS-8
2,4,5-Trichlorophenoxyacetic acid U232 93-76-5
(2,4,5-T)*
[acute waste per 261.31]
Warfarin «0.3%) U240 81-81-2
Xylene U239 1330-20-7
Zinc phosphide «10%) ' U249 1314-84-7
83 ACTIVES
86
-------
§ 162.10 Labeling requirements.
(a) General—<1) Contents of the
label Every pesticide products shall
bear a label containing the Informa-
tion specified by the Act and the regu-
lations in this Part. The contents of a
label must show clearly and promi-
nently the following:
-& The name, brand, or trademark
under which the product is sold as pre-.
scribed in paragraph (b) of this sec-
tion;
(11) The name and address of the
producer, registrant, or person for
whom produced as prescribed in para-
graph (c) of this section:
(111) The net contents as prescribed
in paragraph (d) of this section:
(iv) The product registration
number as prescribed in paragraph (e)
of this section:
87
-------
Environmental Protection Agency
§ 162.10
(v) The producing establishment
number as prescribed in paragraph (f)
of this section;
(vi) An ingredient statement as pre-
scribed in paragraph (g) of this sec-
tion;
(vii) Warning or precautionary state-
ments as prescribed in paragraph (h)
of this section;
(viii) The directions for use as pre-
scribed in paragraph (i) of this section;
and
(ix) The use classification(s) as pre-
scribed in paragraph (j) of this section.
(2) Prominence and legibility, (i) All
words, statements, graphic representa-
tions, designs or other information re-
quired on the labeling by the Act or
the regulations in this part must be
clearly legible to a person with normal
vision, and must be placed with such
conspicuousness (as compared with
other words, statements, designs, or
graphic matter on the labeling) and
expressed in such terms as to render it
likely to be read and understood by
the ordinary individual under custom-
ary conditions of purchase and use.
(11) All required label text must:
(A) Be set in 6-point or larger type;
(B) Appear on a clear contrasting
background; and
(C) Not be obscured or crowded.
(3) Language to be used. All required
label or labeling text shall appear in
the English language. However, the
Agency may require or the applicant
may propose additional text in other
languages as is considered necessary to
protect the public. When additional
text in another language is necessary,
all labeling-requirements will be ap-
plied equally to both the English and
other-language versions of the label-
ing.
(4) Placement of LooeZ-ti) General
The label shall appear on or be secure-
ly attached to the immediate contain-
er of the pesticide product. For pur-
poses of this Section, and the mis-
branding provisions of the Act, "se-
curely attached" shall mean that a
label can reasonably be expected to
remain affixed during the foreseeable
conditions and period of use. If the im-
mediate container is enclosed within a
wrapper or outside container through
which the label cannot be clearly read.
the label tnust also be securely at-
tached to such outside wrapper or con-
tainer, if it is a part of the package as
customarily distributed or sold.
(ii) Tank cars and other bulk con-
tainers—(A) Transportation. While a
pesticide product is in transit, the ap-
propriate provisions of 49 CFR Parts
170-189, concerning the transportation
of hazardous materials, and specifical-
ly those provisions concerning the la-
beling, marking and placarding of haz-
ardous materials and the vehicles car-
rying them, define the basic Federal
requirements. In addition, when any
registered pesticide product is trans-
ported in a tank car. tank truck or
other mobile or portable bulk contain-
er, a copy of the accepted label must
be attached to the shipping papers,
and left with the consignee at the time
of delivery.
(B) Storage. When pesticide prod-
ucts are stored in bulk containers,
whether mobile or stationary, which
remain in the custody of the user, a
copy of the label of labeling, including
all appropriate directions for use, shall
be securely attached to the container
in the immediate vicinity of the dis-
charge control valve.
(5) False or misleading statements.
Pursuant to section 2(qXlXA) of the
Act. a pesticide or a device declared
subject to the Act pursuant to
§ 162.15. is misbranded if its labeling is
false or rpfgjAa/iing in any particular
including both pesticidal and non-pes-
ticidal claims. Examples of statements
or representations in the labeling
which constitute misbranding include:
(i) A false or m<^^«^<"g statement
concerning the composition of the
product;
(ii) A false or misleading-statement
concerning the effectiveness of the
product as a pesticide or device;
(ili) A false or «
-------
§ 162.10
40 CFR Ch. I (7-1-85 Edition)
ingredients if the name suggests one
or more but not all such principal
active ingredients even though the
names of the other ingredients are
stated elsewhere in the labeling:
(vii) A true statement used in such a
way as to give a false or misleading im-
pression to the purchaser;
(viii) Label disclaimers which negate
or detract from labeling statements re-
quired under the Act and these regula-
tions:
(ix) Claims as to the safety of the
pesticide or its ingredients, including
statements such as "safe," "nonpoison-
ous," "noninjurious," "harmless" or
"nontoxic to humans and pets" with
or without sudfi aTqualifying phrase as
"when used as directed": and
(x) Non-numerical and/or compara-
tive statements on the safety of the
product, including but not limited to:
(A) "Contains all natural ingredi-
ents";
(B) "Among the least toxic chemi-
cals known"
-------
Environmental Protection Agency
§ 162.10
or endorsement of the product by the
Agency.
(f) Producing establishments regis-
tration number. The producing estab-
lishment registration number preced-
ed by the phrase "EPA EsL". of the
final establishment at which the prod-
uct was produced may appear in any
suitable location on the label or imme-
diate container. It must appear on the
wrapper or outside container of the
package if the EPA establishment reg-
istration number on the immediate
container cannot be clearly read
through such wrapper or container.
(g) Ingredient statement— <1) Gener-
al The label of each pesticide product
must bear a statement which contains
the name and percentage by weight of
each active ingredient, the total per-
centage by weight of all inert ingredi-
ents; and if the pesticide contains ar-
senic in any form, a statement of the
percentages of total and water-soluble
arsenic calculated as elemental ar-
senic. The active ingredients must be
designated by the term "active ingredi-
ents" and the inert ingredients by the
term ."inert ingredients," or the singu-
lar forms of these terms when appro-
priate. Both terms shall be in the
same type size, be aligned to the same
margin and be equally prominent. The
statement "Inert Ingredients, none" is
not required for pesticides which con-
tain 100 percent active ingredients.
Unless the ingredient statement is a
complete analysis of the pesticide, the
term "analysis" shall not be used as a
heading for the ingredient statement.
(2) Position of ingredient statement.
(i) The Ingredient statement is nor-
mally required on the front panel of
the label. If there Is an outside con-
tainer or wrapper through which the
ingredient statement cannot be clearly
the frigrEKltent statement must
also appear on such outside container
or wrapper. If the size or form of the
package makes it impracticable to
place the ingredient statement on the
front panel of the label, permission
may be granted for the ingredient
statement to appear elsewhere.
(ii) The text of the Ingredient state-
ment must run parallel with other
text on the panel on which it appears,
and must be clearly
from and must not be placed in the
body of other text.
(3) Names to be used in ingredient
statement. The name used for each in-
gredient shall be the accepted
common name, if there is one. fol-
lowed by the chemical name. The
common name may be used alone only
if it is well known. If no common name
has been established, the chemical
name alone shall be used. In no case
will the use of a trademark or proprie-
tary name be permitted unless such
name has been accepted as a common
name by the Administrator under the
authority of Section 2S(cX6).
(4) Statements of percentages. The
percentages of ingredients shall be
stated in terms of weight-to-weight. •
The sum of percentages of the active
and the inert ingredients shall be 100.
Percentages shall not be expressed by
a range of values such as "22-25%." If
the uses of the pesticide product are
expressed as weight of active ingredi-
ent per unit area, a statement of the
weight of active ingredient per unit
volume of the pesticide formulation
shall also appear in the ingredient
statement.
(5) Accuracy of stated percentages.
The percentages given shall be as pre-
cise as possible reflecting good manu-
facturing practice. If there may be un-
avoidable variation between manufac-
turing batches, the value stated for
each active ingredient shall be the
lowest percentage which may be
present.
(6) Dstcricrzticx. Pesticides which
change in chemical composition sig-
nificantly must meet the following la-
beling requirements:
(i) In cases where It-is determined
that a pesticide formulation changes
chemical composition significantly.
the product must bear the following
statement in a prominent position on
the label: "Not for sale or use after
Cdatel."
(ii) The product must meet all label
rfflimg up to the expiration time indi-
cated on the labeL
(7) Inert ingredient*. The Adminis-
trator may require the name of any
Inert Ingredlentfe) to be listed In the
Ingredient statement If he determines
that such ingredlentts) may pose a
hazard to man or the environment.
90
-------
§ 162.10
40 CFR Ch. I (7-1-85 Edition)
(h) Warnings and precautionary
statements. Required warnings and
precautionary statements concerning
the general areas of toxicological
hazard including hazard to children,
environmental hazard, and physical or
chemical hazard fall into two groups;
those required on the front panel of
the labeling and those which may
appear elsewhere. Specific require-
ments concerning content, placement.
type size, and prominence are given
below.
(1) Required front panel statements.
With the exception of the child
hazard warning statement, the text re-,
quired on the front panel of the label
is determined by the Toxicity CategOr
ry of the pesticide. The category is as-
signed on the basis of the highest
hazard shown by any of the indicators
in the table below:
Huwd Mteiton
o~"'n. .
fymaHm^
ffrfa tfftcto
1
Up to «id kidudmg SO
mg/kQ.
mg/itor.
mg/kg.
Corrosfcv; oomMl
within 7 ocySk
Toxfcftyc
N
ftom 60 tfvu 500 mg/kg.
Awn 9 tfvu 9 nvi/Wjv
finm 9Afl Mmi 9ATV1
day* Mtaflon
pmiiUnj lor 7 dcyv.
hours.
wtogorie*
m
From 500 tfwu 6000 mo/
KB.
Prrvn 9 tfwii flfl •wr/fif^*
No oomMl opMtty;
wWihi7d^i.
MotfMrtt tnWlon it 72
hour*.
IV
GfMtar ttun 5000 mo/
-ka.
fSf^«tv than ^A HM/M^
Mid or tight bfttttion at
72 hour*.
(i) Human hazard signal word— (A)
Toxicity Category L All pesticide prod-
ucts meeting the criteria of Toxicity
^Category T shall bear on the front
panel the signal word "Danger." In ad-
dition if the product was assigned to
Toxicity Category I on the basis of its
oral, inhalation or dermal toxicity (as
distinct from gfcin and eye local ef-
fects) the word "Poison" shall appear
in red on a background of distinctly
contrasting color and the skull and
crossbones shall appear In Immediate
proximity to the word "poison."
(B) Toxicity Category IL All pesti-
cide products meeting the criteria of
Toxicity Category n shall bear on the
front panel the signal word "Warn-
ing."
(C) Toxicity Category HL AH pesti-
cide products meeting the criteria of
Toxicity Category in shall bear on
the front panel the signal word "Cau-
tion."
nt may "the Administra-
tor waive this requirement.
(iii) Statement of practical treat-
numt-CA) Toxicity Category 'L A
statement of practical treatment {first
aid or other) shall appear on the front
panel of the label of all pesticides fall-
ing into Toxicity Category I on the
baste of oral« tahftlfltfrrn or dermal tox-
icity. Tne Agency may, 'however,
permit reasonable variations In the
placement of the gtrMfro^nt of practi-
cal treatment is some reference such
as "See statement of practical treat-
ment on back panel" appears on the
91
-------
Environmental Protection Agency
§ 162.10
front panel near the word "Poison"
and the skull and crossbones.
(B) Other toxicity categories. The
statement of practical treatment is not
required on the front panel except as
described in paragraph (hXIXiiiXA) of
this section. The applicant may. how-
ever, include such a front panel state-
ment at his option. Statements of
practical treatment are. however, re-
quired elsewhere on the label in
accord with paragraph (h)<2) of this
section if they do not appear on the
front paneL
(iv) Placement and prominence. All
the require front panel warning state*
ments shall 6e grouped together on
the label, and shall appear with suffi-
cient prominence relative to other
front panel text and graphic material
to make them unlikely to be over-
looked under customary conditions of
purchase and use. The following table
shows the minimum type size require-
ments for the front panel warning
statements on various sizes of labels:
Six* of label from panel in square
inches
5 end under
Ahnu. « In 10
AhTMl 10 to «*
Ahnu. 1«! In Trt
rt>^,tfi
Points
Acquired
Signal
word, afl
capiuts
6
10
12
14
18
-Kflepoui
o< roach o<
ch*dreo-
6
6
6
10
12
(2) Other required warnings and pre-
cautionary statements. The warnings
and precautionary statements as re-
quired below shall appear together on
the label under the general heading
"Precautionary Statements" and
under appropriate subheadings of
"Hazard to Humans and Domestic Ani-
mals," "Environmental Hazard" and
"Physical or Chemical Hazard."
(i) Hazard to humans and domestic
animals. (A) Where a hazard exists to
humans or domestic animals, precau-
tionary statements are required indi-
cating the particular hazard, the
route
-------
§ 162.10
40 CFR Ch. I (7-1-85 Edition)
stances under which they are required
follow:
(A) If a pesticide intended for out-
door use contains an active ingredient
with a mammalian acute oral LDM of
100 or less, the statement "This Pesti-
cide is Toxic to Wildlife" is required.
(B) If a pesticide intended for out-
door use contains an active ingredient
with a fish acute LCM of 1 ppm or less.
the statement "This Pesticide is Toxic
to Fish" is required.
If required by the Agency, such
printed or graphic matter Is securely
attached to each package of the pesti-
cide, or placed within the outside
wrapper or bag;
03) The label bears a reference to
the directions for use in accompanying
leaflets or circulars, such as "See di-
rections In the enclosed circular:'' and
(C) The Administrator determines
that it is not necessary for such direc-
tions to appear on the labeL
(lii) Exception* to requirement for
direction for «se-(A) Detailed direc-
tions for use may be omitted from la-
beling of pesticides which are intended
93
-------
Environmental Protection Agency
§ 162.10
for use only by manufacturers of prod-
ucts other than pesticide products in
their regular manufacturing processes.
provided that:
(/) The label clearly shows that the
product is intended for use only in
manufacturing processes and specifies
the type
-------
APPENDIX III
USE INDEX APPENDICES
95
-------
EPA Index to Pesticide Chemicals
METOLACHLOR ' ' *A L-
TABLE OF CONTENTS
Site Name Page
TERRESTRIAL FOOD-CROP 3
(Agricultural Crops) 3
Beans (garbanzo, great northern, kidney, lima, mung, navy,
pinto, snap, white, and English and southern peas) 4
Corn 5
Cotton 7
Okra 8
Peanuts 8
Potato ' 9
Safflower 9
Sorghum, Forage 10
Sorghum, Grain 10
Soybeans 11
TERRESTRIAL NON-FOOD CROP 13
(Ornamental Plants and Forest Trees) 13
American Holly 14
Andorra Juniper 14
Arborvitae . 14
Aucuba 13
14
Azalea (Hershey Red, Herbert, Purple Splendor) 14
Bar Harbor Juniper 14
Boxwood 14
Cotoneaster 14
Crabapple 14
Creeping Juniper 14
Dwarf Japanese Yew 14
English Ivy 14
Euonymus 14
Firethorn 14
Forsythia 14
Hicks Yew 14
Holly 13
Honeysuckle 14
Hybrid Tea Roses 14
Japanese Andromeda 14
Japanese Holly 14
Japanese Maples 14
Juniper 13
Leucothoe 14
Lilac (James McFarland) 14
Liriope (Silver Sunproof) 13
14
Maple 14
Mentor Barberry 14
Mountain-Laurel 14
Osmanthus 14
Pachysandra 14
Issued: 2/21/86 I-108801-i
96
-------
EPA Index to Pesticide Chemicals
METOLACHLOR
TABLE OF CONTENTS
Site Name • Page
Privet 14
Purpleleaf Wintercreeper 14
Red Oak 14
Red Osier Dogwood 14
Rhododendron 14
Rose (miniature) 14
Rosebay Rhododendron 14
Shore Juniper 14
Spirea 14
Spring Glory Forsythia 14
Viburnum 14
Warty Barberry 14
Weigela 14
Wintergreen Barberry 14
(Noncrop^ Wide Area; and General-Indoor/Outdoor Treatments) 15
Highway Rights-of-Way 15
Railroad Rights-of-Way 15
Issued: 2/21/86 I-108801-ii
97
-------
EPA Index to Pesticide Chemicals
*
h'108801 METOLACHLOR*
TYPE PESTICIDE; Herbicide
FORMULATIONS;
Tech (95%)
G (15%, 25%)
EC (8 Ib/gal)
F1C (27.5% (2.5 Ib/gal), 31.8% (2.9 Ib/gal), 36.1% (3.3 Ib/gal), 36.3%
3.3 Ib/gal))
GENERAL WARMINGS AND LIMITATIONS; A selective herbicide recommended as a
preplant surface-applied, preplant incorporated, or preemergence treatment
for controlling annual grasses and certain broadleaf weeds. Dry weather
following preemergence applications may reduce effectiveness. Where a
dosage range is given, use lower rate on coarse-textured soils or those
low in organic matter; use higher rate on fine-textured soils or those
high in organic matter. Apply alone or in tank mixtures by ground equip-
ment in a minimum of.10 gallons of spray mixture per acre unless otherwise
specified. Apply in water alone or in tank mixtures with listed herbi-
cides in a minimum total volume of 2 gallons per acre by aircraft.
Agricultural Crop Tolerances (other than those listed in the text):
Peppers, chili
Indirect -or Inadvertent
Barley, fodder
Barley, forage
Barley, grain
Buckwheat, fodder
Buckwheat, forage
Buckwheat, grain
Millet, fodder
Millet, forage
Millet, grain
Milo, fodder
Milo, forage
Milo, grain
Oats, fodder
Oats , forage
Oats, grain
Rice, fodder
Rice, forage
Rice, grain
Rye, fodder
Rye , forage
Rye, grain
Wheat, fodder
Wheat, forage
Wheat, grain
Livestock Tolerances :
Cattle, fat
Cattle, meat
Cattle, mbyp
Eggs
0.5 ppm
Tolerances
0.5 ppm
0.5 ppm
0.1 ppm
0.5 ppm
0.5 ppm
0.1 ppm
0.5 ppm
0.5 ppm
0.1 ppm
0.5 ppm
0.5 ppm
0 . 1 ppm
0.5 ppm
0.5 ppm
0.1 ppm
0.5 ppm
0.5 ppm
0.1 ppm
0.5 ppm
0.5 ppm
0.1 ppm
0.5 ppm
0.5 ppm
0.1 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
*2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-l-methylethyl)acetamide
Issued: 2/21/86 1-108801-1
98
-------
EPA Index to Pesticide Chemicals
METOLACHLOR
GENERAL WARNINGS AND LIMITATIONS (continued)
Goats, fat
Goats, meat
Goats, mbyp
Hogs, fat
Hogs, meat
Hogs, mbyp
Horses, fat
Horses, meat
Horses, mbyp
Milk
Poultry, fat
Poultry, meat
Poultry, mbyp
Sheep, fat
Sheep, meat
Sheep, mbyp
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
0.02 ppm
TIME REQUIRED FOR CONTROL; Not located.
PHYTOTOXICITY-TO TARGET WEEDS; Not located.
PHYTOTOXICITY TO CROPS; Injury may occur following use of product under
abnormally high soil moisture conditions during early development of the
•crop.
MODE OF ACTION: The chloracetamide herbicides are general growth inhibi-
tors, especially of root elongation. Metolachlor may disrupt the integri-
ty of plant cell membranes, and inhibit lipid synthesis.
BROADLEAF WEEDS CONTROLLED;
PEWAIBE Black nightshade
PADABBA Carpetweed
PEDADBA Common purslane (a)
PCQAUBC • Florida beggarweed (b), -
PEMAEBB Florida pusley
PBFBOAA Galinsoga
PEWAIBG Hairy nightshade (a)
PAAAABI Pigweed
(a) Weeds partially controlled.
(b) Partially controlled with a minimum of 2 Ib a.i./A, applied pre-
emergence.
Issued: 2/21/86
1-108801-2
99
-------
PCABHBB
PCABFAA
PCABCBA
PCACHED
PCACUBC
PCACUBA
PCABIBA
PCACUBF
PCACWBC
PCABLBC
PCACCBA
PCAAWAA
PCACWBB
PCAARAA
PCABLBA
PCACEBL
PCACEBC
PCACUSD
PBMADBI
EPA Index to Pesticide Chemicals
METOLACHLOR
GRASSES AND OTHER MONOCOTS CONTROLLED:
Barnyardgrass
Crabgrass
Crovfootgrass
Fall panicum
Foxtail millet
Giant foxtail
Goosegrass
Green foxtail
Johnsongrass (seedling)
Prairie cupgrass
Rice
Sandbur
Shattercane
Signalgrass
Southwestern cupgrass
Texas panicum
Witchgrass
Yellow foxtail
Yellow nutsedge
(a)
(a)
(a)
(c)
(a) Weeds partially controlled.
(c) Partially controlled with a minimum of 2 Ib a.i./A, applied
through a center pivot irrigation system.
Site,"Dosage Tolerance, Use, Limitations
and Formulation
(Ib a.i./A)
TERRESTRIAL FOOD CROP
(Agricultural Crops)
General-Warnings and Limitations;
PrepIant Surface-Applied; This is for minimum or no-tillage system
only. Treated soil should not be:moved out of the row or untreated soil
should not be moved to the surface during planting, as weed control will
be diminished.
Preplant Incorporated; Apply to soil and incorporate into top 2 inches
of soil within 14 days before planting. Use preplant incorporated ap-
plication if furrow irrigation is used or when a period of dry weather
after application is expected. If crop will be planted on beds, apply
and incorporate after bed formation unless otherwise specified
Preemergence: Apply during planting (behind the planter) or after
planting, but before weeds or crops emerge.
Center Pivot Irrigation Application; Apply alone or with tank mixtures
of atrazine, or others which are registered for center pivot
application. Apply in irrigation water preemergence (after planting
but before weeds or crops emerge). Mixture is prepared with minimum of
Issued: 2/21/86
1-108801-3
100
-------
EPA Index to Pesticide Chemicals
ite, Dosage
and Formulation
(lb a.i./A)
METOLACHLOR
Tolerance; Use, Limitations
General Warnings-and Limitations (continued)
1 part water to 1 part herbicide(s). Inject mixture into center pivot
system using positive displacement pump. Apply in 0.5 to 1 inch of
water, using lower volume of water on coarse textured soils. More than
1 inch of water at application may reduce weed control by moving herbi-
cide(s) below the effective zone in the soil.
Beans (garbanzo,
great northern,
kidney, lima, mung,
navy, pinto, snap,
white, and English
and southern peas)
1.5-3
(25% G)
(8 Ib/gal EC)
1.25r2.5
(8 Ib/gal EC)
1.5-3
(25Z G)
(8 Ib/gal EC)
1.25-2.5
(8 Ib/gal EC)
1.25-2.5
(8 Ib/gal EC)
0.3 ppm (seed and pod vegetables)
General Information; Use only preemergence appli-
cations on English peas. Do not use on English
peas in northeastern United States.
Preplant incorporated. The emulsifiable concen-
trate formulation may be tank mixed witn triflura-
lin in dry, lima, and snap beans; or with chloram-
ben in white, navy, kidney, pinto, and lima beans.
Preplant incorporated.
Tank mix with EPIC in green or dry beans; or apply
prior to a preemergence or at emergence applica-
tion of dinoseb in field, lima, or snap beans.
Preemergence. The EC formulation may be tank
mixed with chloramben in white, navy, kidney,
pinto, and lima beans.
Preemergence.
Tank mix with dinoseb in field, lima, or snap
beans; or-apply prior to an at emergence applica-
tion of ditiofi'eb in field, lima, or snap beans; or
apply after a preplant incorporated application
of EPTC in green or-dry beans.
Early postemergence. Apply during early emergence
when beans are in, but not beyond the crook stage.
Tank mix with dinoseb in field, lima, or snap
beans.
Issued: 2/21/86
1-108801-4
101
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EPA Index to Pesticide Chemicals
/15005AA
Site, Dosage
and Formulation
(Ib a.i./A)
Corn
1.5-4
(25Z G)
or
2-4
(8 Ib/gal EC)
[MAI]
1.98-3.13
(2.5 Ib/gal, 3.3
Ib/gal F1C)
2-3
(8 Ib/gal EC)
1.49-2.5
(8 Ib/gal EC)
[MAI]
1.49-2.5
(2.5 Ib/gal, 3.3
Ib/gal F1C)
or
1.81-2.54
(2.9 Ib/gal F1C)
1.5-4
(252 G)
(8 Ib/gal EC)
METOLACHLOR
Tolerance, Use, Limitations
0.1 ppm (fresh (including sweet, kernel plus cob
with husk removed))
0.1 ppm (grain)
1.0 ppm (fodder and forage)
Use limited to CO, DE, IN, IL, IA, KS, KY, MD, MI,
MN, MO, MT, NE, NY, ND, OH, PA, SD, VA, WV, WI,
and WY. Preplant. Broadcast to soil surface in
minimum or no-till systems only. Apply two-thirds
the rate as a split treatment 30 to 45 days prior
to planting, and the remaining one-third at plant-
ing. Treatments less than 30 days prior to plant-
ing may be made either as a split or single appli-
cation. Apply the lowest rate (for coarse soils)
not more than 2 weeks prior to planting.
May be formulated with atrazine.
The granular formulation may be followed with a
treatment with paraquat; or glyphosate, if weeds
are present at the time of application.
.May be followed by a postemergence application of
atrazine; or atrazine and metolachlor; or 2,4-D;
or dicamba; or bromoxynil.
Use limited to CO, DE, IN, IL, IA, KS, KY, MD, MI,
MN, MO, MT, NE, NY, ND, OH, PA, SD, VA, WV, WI,
and WY. Preplant. Broadcast to soil surface in
minimum or no-till systems only.
Tank mix with atrazine; or simazine; or atrazine
and simazine.
Preplant. Broadcast to soil surface in minimum
or no-tifcl. systems only.
Tank mix with atrazine; or cyanazine; or metola-
chlor; or simazine; or atrazine and cyanazine; or
atrazine and simazrne; or atrazine and 2,4-D; or
atrazine and 2,4-D and dicamba; or cyanazine and
2,4-D; or cyanazine and 2,4-D and dicamba; or
atrazine and cyanazine and 2,4-D and dicamba; and
to each of these, may be added paraquat or glypho-
sate.
May be formulated with atrazine.
Preplant incorporated. Apply and incorporate into
the top 2 inches (4 to 6 inches in CA) of soil
within 14 days before planting. The granular
formulation may be followed by sequential applica-
tions of ryanazine; or dicamba.
Issued: 2/21/86
1-108801-5
102
-------
Site, Dosage
and Formulation
(Ib a.i./A)
Corn (continued)
1.25-3.5
(8 Ib/gal EC)
[MAI]
1.24-2.5
(2.5 Ib/gal, 3.3
Ib/gal F1C)
or
1.45-2.54
(2.9 Ib/gal F1C)
1.25-2.5
(8 Ib/gal EC)
1.5-4
(25% G)
(8 Ib/gal EC)
[MAI]
1,24-2.5
(2.5 Ib/gal, 3.3
Ib/gal F1C)
or
1.45-2.54
(2.9 Ib/gal F1C)
1.25-2.5
(8 Ib/gal EC)
1.25-3.5
(8 Ib/gal EC)
2-2.5
(8 Ib/gal EC)
1.25-3.5
(8 Ib/gal EC)
EPA Index to Pesticide Chemicals
METOLACHLOR
Tolerance; Use,"Limitations
Preplant incorporated.
Tank mix the EC formulation with atrazine; or
simazine; or atrazine and simazine.
The flovable concentrate formulations are formu-
lated with atrazine, and may be tank mixed with
more atrazine; or more metolachlor; or simazine;
or cyanazine.
Preplant incorporated.
Tank mix with cyanazine; or atrazine and cyanazine
in field corn or silage corn only.
Preemergence.
The granular formulation may be followed by se-
quential applications of cyanazine; or dicamba.
The flowable concentrate formulations are formu-
lated with atrazine, and may be tank mixed with
more atrazine; or more metolachlor; or simazine;
or cyanazine.
Preemergence.
Tank mix with cyanazine; or atrazine and cyanazine
in field corn or silage corn only.
Preemergence.
Tank mix with atrazine; or simazine; or atrazine
and simazine.
Use limited to flat-planted corn in IL, IN, LA,
MN, NE, OH, SD, and WI. Preemergence.
Tank mix with dicamba.
Preemergence.
Tank mix with atrazine and linuron; or in the
northeast United States (including HI, IN, and
KY), tank mix with atrazine and pendimethalin; or
simazine and pendimethalin.
Issued: 2/21/86
1-108801-6
103
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EPA Index to Pesticide Chemicals
/23005AA
Site, Dosage
and Formulation
(Ib a.i./A)
Corn (continued)
1.5-2.5
(8 Ib/gal EC)
[MAI]
1.49-2.5
(2.5 Ib/gal, 3.3
Ib/gal F1C)
or
1.81-2.54
(2.9 Ib/gal F1C)
1.49-2.5
(8 Ib/gal EC)
IMAI]
1.49-2.5
(2.5 Ib/gal, 3.3
Ib/gal FLC)
".or
1.81-2.54
(2.9 Ib/gal F1C)
Cotton
1.5-2
(8 Ib/gal EC)
METOLACHLOR
Tolerance, Use, Limitations
1.25-2
(8 Ib/gal EC)
1.5-2
(8 Ib/gal EC)
1.25-2
(8 Ib/gal EC)
Preemergence. For use in minimum or no-till sys-
tems only.
Tank mix with atrazine; or cyanazine; or linuron;
or metolachlor; or simazine; or atrazine and cyan-
azine; or atrazine and simazine; or atrazine and
2,4-D; or atrazine and 2,4-D and dicamba; or cyan-
azine and 2,4-D; or cyanazine and 2,4-D and dicam-
ba; or atrazine and cyanazine and 2,4-D and dicam-
ba; and to each of these, may be added paraquat
or glypnosate.
Hay be formulated with atrazine.
Postemergence. Apply before weeds pass the 2-leaf
stage, and before corn exceeds 5 inches in height.
Do not apply in fluid fertilizer, or severe crop
injury may occur.
Tank mix the emulsifiable concentrate formulation
with atrazine.
0.1 ppm (cottonseed)
Use limited to AR, LA, MS, NM, OK, TN, TX, and
Bootheel of MO. Preplant incorporated. Incorpo-
rate into top 1 inch of soil immediately before
planting, at planting, or after planting. Plant
cotton be.low.zone of incorporation. Use on sandy
loam soils only in NM, OK, and TX.
Use limited to NMK't)K, and TX (Blacklands, Gulf
Coast, Rio Grande Valley, High Plains, Rolling
Plains, Edwards Plateau, and Southwest). Preplant
incorporated.
Tank mix with prometryn.
Use limited to AR, LA, MS, NM, OK, TN, TX, and
Bootheel of MO. Preemergence.
Use limited to NM, OK, and TX (Blacklands, Gulf
Coast, Rio Grande Valley, High Plains, Rolling
Plains, Edwards Plateau, and Southwest). Pre-
emergence.
Tank, mix with prometryn.
Issued: 2/21/86
1-108801-7
104
-------
/15015AA
/15006AA
Site, Dosage
and Formulation
(Ib a.i./A)
Okra
1.5-3
(25% G)
1.5-3
(25% G)
Peanuts
1.5-2
(8 Ib/gal EC)
or
1.5-3
(25% G)
1.25-2
(8 Ib/gal EC)
or
1.5-3
(25% G)
1.5-2
(8 Ib/gal EC)
1.5-3
(25% G)
(8 Ib/gal EC)
1.25-2
(8 Ib/gal EC)
or
1.5-3
(25% G)
1.5-3
(8 Ib/gal EC)
EPA Index to Pesticide Chemicals
METOLACHLOR
Tolerance, Use, Limitations
0.3 ppm (seed and pod vegetables)
Preplant incorporated. Apply and incorporate
within the surface 1 to 2 inches of soil vithin
14 days before planting.
Preemergence.
0.1 ppm (peanuts)
3.0 ppm (forage and hay)
1.0 ppm (hulls)
General Information; Metolachlor alone may be
applied after preplant incorporated applications
of benfluralin; or trifluralin; or vernam.
Use limited to southeast United States. Preplant
or postplant incorporated. Hay be followed by a
sequential, cracking time treatment with sodium
salt of dinoseb and sodium N-1-naphthyIphthala-
mate.
Use limited to NM, OK, and TX. Preplant or post-
plant incorporated. Hay be followed by a sequen-
tial, cracking time treatment with sodium salt of
dinoseb and sodium N-1-naphthylphthalamate.
Preplant incorporated. Apply and incorporate up
to 14 days prior to planting.
Tank mix with benfluralin.
Use limited to southeast United States. Pre-
emergence. Use the highest dosage only for par-
tial control of Florida beggarweed.
Use limited to NM, OK, and IX. Preemergence.
Early postemergence. Apply at cracking time. Use
the highest dosage in the southeast United States
only for heavy weed infestations and better con-
trol of Florida beggarweed.
Tank mix with sodium salt of dinoseb and sodium
N-1-naphthylphthalamate.
Issued: 2/21/86
1-108801-8
105
-------
/14013AA
/08034AA
Site, Dosage
and Formulation
(Ib a.i./A)
Peas (English and
Southern)
Potato .
EPA Index to Pesticide Chemicals
METOLACHLOR
Tolerance, Use, Limitations
1.5-3
(25X G)
(8 Ib/gal EC)
1.5-4
(25% G)
(8 Ib/gal EC)
1.5-3
(8 Ib/gal EC)
1.5-3
(8 Ib/gal EC)
2.5
(8 Ib/gal EC)
Safflower
1.5-3
(8 Ib/gal EC)
Refer to Beans.
0.2 pptn
Do not harvest within 60 days after a planting to
drag-off application, or within 40 days after a
layby application. Do not exceed 5.5 pounds ac-
tive ingredient per acre per season.
General Information; Do not use on muck or peat
soils. If cool, wet soil conditions occur after
application, maturity may be delayed and/or yield
reduced with Superior and other early maturing
varieties. Do not apply both preemergence and
preplant or postplant incorporated treatments.
Do not use in Kern County, CA.
Preplaut or postplant incorporated. Apply and in-
corporate into the top 3 inches of soil preplant,
or top 2 inches of soil postplant up to dragoff.
Do not damage potato seed pieces or sprouts with
incorporation equipment. May be followed by a
preemergent application of metribuzin; or a layby
application of metolachlor (see use, below).
Preemergence. The highest dosage is only used
when metolachlor is applied alone where soil or-
ganic matter is between 6 to 20 percent.
Preemergence.
Tank mix with metribuzin; or dinoseb; or with
linuron (east of the Rocky Mountains).
Postemergency. Directed spray. Apply up until
after the last hilling.
Tank mix with metribuzin.
Layby application. Apply after hilling, at layby.
This may follow an earlier incorporated or pre-
emergence application of metolachlor, as long as
a total of 5.5 pounds active ingredient per acre
is not exceeded in a single crop season.
0.1 ppm (safflower seed)
Preplant incorporated. Incorporated into top 2
inches of soil (4 to 6 inches in CA) within 14
days before planting.
Issued: 2/21/86
1-108801-9
106
-------
/22004AA
/24006AA
Site; Dosage
and Formulation
Ub a.i./A)
EPA Index to Pesticide Chemicals
METOLACHLOR
Tolerance, Use; Limitations
Safflower (continued)
1.5-3
(8 Ib/gal EC)
Sorghum, Forage
Sorghum, Grain
2-2.5
(8 Ib/gal EC)
[MAI]
2-2.5
(2.5 Ib/gal F1C)
or
1.98-2.48
(3.3 Ib/gal F1C)
1.5-2.5
(8 Ib/gal EC)
1.49-2
(8 Ib/gal EC)
or
Preemergence.
0.3 ppm (grain)
2.0 ppm (forage and fodder)
Do not exceed one application per year.
General Information; If sorghum seed has not been
properly treated witn a safener such as N-(l,3-
dioxolan-2-yl-methoxy)-iminobenzene acetonitrile,
severe crop injury will result. Under high soil
moisture conditions prior to sorghum emergence,
injury may occur following use of metolachlor.
The crop will normally outgrow this effect. Do
not use on sorghum grown under dry mulch tillage
or crop injury may occur. Under dry conditions,
irrigate after application.
Use limited to CO, IL, IA, KS, MO, NE, and SD.
Preplant. Broadcast to soil surface in minimum-
tillage or no-tillage systems only. May be ap-
plied up to 45 days before planting. Use only
split applications for treatments made 30 to 45
days prior to planting with two-thirds of the rate
applied initially and the remaining one-third at
planting. Treatments less than 30 days prior to
planting may be made either as a split or single
application. Apply the lowest rate (for coarse
soils) not more than 2 weeks prior to planting.
May be formulated with atrazine, or tank mixed
with atrarihe,for use on medium and fine soils in
all of the above areas except CO.
May be tank mixed with propazine in eastern CO,
and central and western KS.
If weeds are present at the time of treatment,
metolachlor alone, formulated with or tank mixed
with atrazine may be tank mixed with glyphosate;
or paraquat.
Preplant incorporated. Apply and incorporate into
the top 2 inches of soil within 14 days prior to
planting.
Preplant incorporated.
Tank mix with, or formulated with atrazine.
Issued: 2/21/86
I-108801-IO
107
-------
EPA Index to Pesticide Cnemicals
/28023AA
Site, Dosage
and Formulation
(Ib a.i./A)
METOLACHLOR
Tolerance, Use, Limitations
Sorghum, Forage cluster (continued)
[MAI]
1.49-2
(2.5 Ib/gal, 3.3
Ib/gal F1C)
1.25-2.1
(8 Ib/gal EC)
[MAI]
1.24-2.06
(3.3 Ib/gal F1C).
1.5-2.5
(8 Ib/gal EC)
1.5-2
(8 Ib/gal EC)
[MAI]
1.49-2
(2.5 Ib/gal, 3.3
Ib/gal F1C)
1.25-2.1
(8 Ib/gal EC)
[MAI]
1.24-2.1
(3.3 Ib/gal F1C)
Soybeans
2-3
(252 G)
(8 Ib/gal EC)
Preplant incorporated.
Tank mix with, or formulated with propazine; or
tank mix with terbutryn.
Preemergence. If weeds are present at the time
of treatment, may be tank mixed with glyphosate;
or paraquat in minimum or no-till systems.
Preemergence.
Tank mix with, or formulated with atrazine. If
weeds are present at the time of treatment, may
be tank mixed with glyphosate; or paraquat in
minimum or no-till systems.
Preemergence.
Tank mix with, or formulated with propazine; or
tank mix with terbutryn.
0.1 ppm (soybeans)
2.0 ppm (forage and *f odder)
Use limited to CO, IL, IN, IA, KS, KY, MN, MO, MT,
NE, ND, SD, HI, and WY. Preplant. Broadcast to
soil surface in minimum-tillage or no-tillage sys-
tems only. Apply two-thirds the rate as a split
treatment 30 to 45 days prior to planting, and the
remaining one-third at planting. Treatments less
than 30 days prior to planting may be made either
as a split or single application. Apply the low-
est rate (for coarse soils) no't more than 2 weeks
prior to planting.
Issued: 2/21/86
I-108801-I1
108
-------
EPA Index to Pesticide Chemicals
Site, Dosage
and Formulation
(Ib a.i./A)
Soybeans (continued)
1.5-2.5
(8 Ib/gal EC)
METOLACHLOR
Tolerance, Use, Limitations
1.5-3
(25% G)
(8 Ib/gal EC)
1.25-2.5
(8 Ib/gal EC)
1.5-2.5
(8 Ib/gal EC)
1.5-3
(25% G)
(8 Ib/gal EC)
1.5-2.5
(8 Ib/gal EC)
1.25-2.5
(8 Ib/gal EC)
Preplant. Broadcast to soil surface in minimum-
tillage or no-tillage systems only.
Tank mix with linuron and paraquat; or linuron and
glyphosate; or metribuzin and paraquat; or metri-
buzin and glyphosate.
Preplant incorporated. Apply and incorporate into
the top 2 inches of soil within 14 days prior to
planting.
The emulsifiable concentration formulation may be
tank mixed with chloramben and metribuzin; or
trifluralin.
The granular formulation may be followed by pre-
emergent, sequential applications of chloramben;
or dinoseb; or dinoseb and sodium N-1-naphthyl-
phthalamate; or linuron; or metribuzin.
Preplant incorporated.
Tank mix with metribuzin; or follow with a sequen-
tial preemergence application of metribuzin.
Preplant incorporated.
Tank mix with chloramben; or follow with a sequen-
tial preemergence application of chloramben; or
follow with a sequential preemergence or ground
crack application of dinoseb.
Preemergence.
The emulsifiable concentrate formulation may be
tank mixed^ with chloramben and metribuzin.
*\. ^
Preemergence.
Tank mix with chloramben; or dinoseb; or follow
with a sequential application at ground crack of
dinoseb in conventional tillage systems.
Tank mix with linuron and paraquat; or linuron and
glyphosate; or metribuzin and paraquat; or metri-
buzin and glyphosate in minimum or no-till sys-
tems .
Preemergence.
Tank mix with metribuzin; or linuron; or dinoseb
and sodium N-1-naphthylphthalamate.
Issued: 2/21/86
1-108801-12
109
-------
Site, Dosage
and Formulation
(16 a.i./A)
Soybeans (continued)
1.5-3
(8 Ib/gal EC)
1.5-2.5
(8 Ib/gal EC)
1.25-2.5
(8 Ib/gal EC)
EPA Index to Pesticide Chemicals
METOLACHLOR
Tolerance, Use, Limitations
Early postemergence. Apply when soybeans are
still in the cotyledon stage, before leaves open
to expose the terminal bud.
Tank mix with dinoseb.
Early postemergence. Apply as late as ground
cracking.
Tank mix with dinoseb.
Early postemergence. Apply through the crook
stage, anytime from soil cracking to before the
soybean true leaves open.
Tank mix with dinoseb and sodium N-1-naphthyl-
phthalamate.
/34149DA
/34070DA
/35073DA
/31458DA
TERRESTRIAL NON-FOOD CROP
(Ornamental Plants and Forest Trees)
General Warnings and Limitations: Do not use on seedbeds, on unrooted
cuttings, or prior to transplanting. Do not apply granules to wet or-
namental foliage. Do not use in greenhouses or other enclosed struc-
tures. Do not make more than 2 applications per year.
Aucuba
Holly
Juniper
Liriope (Silver . .li??
Sunproof) '•*'• ^«
1.95-4.05
(15%, 25% G)
Broadcast, using a cyclone or similar type appli-
cator. Apply to established ornamentals or to
ornamentals transplanted for at least 5 days.
Simazine may be applied just before or after
metolachlor treatment for control of annual broad-
leaf weeds.
Issued: 2/21/86
1-108801-13
110
-------
EPA Index to Pesticide Chemicals
METOLACHLOR
Site, Dosage
and Formulation
(Ib a.i./A)
/35142DA American Holly
/35315DA Andorra Juniper
/35021DA Arborvitae*
/-34149DA Aucuba*
/34500DA Azalea (Hershey Red,
Herbert, Purple
Splendor)
/35342DA Bar Harbor Juniper
/3403 IDA Boxwood
/34045DA Cotoneaster*
/35056DA Crabapple*
/35160DA Creeping Juniper
/34537DA Dwarf Japanese Yew*
/34052DA English Ivy
/34053DA Euonymus
/34058DA Firethorn
/34062DA Forsythia
/35338DA Hicks Yew
/34072DA Honeysuckle
/34238DA Hybrid Tea Roses
. /34078DA Japanese Andromeda*
i /34080DA Japanese Holly*
«187DA " Japanese Maples
087DA Leucothoe*
089DA Lilac (James McFar-
land)
/31458DA Liriope* (Silver Sun-
proof)
/35083DA Maple*
/34245DA Mentor Barberry
/34097DA Mountain-Laurel
/34199DA Osmanthus*
/34106DA Pachysandra
/34088DA Privet
/33117DA Purpleleaf Winter-
creeper
/35105DA Red Oak
/34277DA Red Osier Dogwood
/34118DA Rhododendron*
/34120DA Rose (miniature)
/34314DA Rosebay Rhododendron
/35209DA Shore Juniper
/34130DA Spirea
/34453DA Spring Glory For-
sythia
/34137DA Viburnum
/34536DA Warty Barberry
J4140DA Weigela*
p4291DA Wintergreen Barberry
Issued: 2/21/86
Tolerance, Use, Limitations
1-108801-14
1 11
-------
/67004AA
/67005AA
Site, Dosage
and Formulation
(Ib a.i./A)
EPA Index to Pesticide Chemicals
METOLACHLOR
Tolerance, Use, Limitations
American Holly cluster (continued)
1.95-4.05
(151, 25% G)
or
2-3
(8 Ib/gal EC)
Broadcast to established ornamentals or to orna-
mentals at least 5 days after transplanting. Ap-
ply the granular formulation with a cyclone or
similar type applicator.
The EC formulation may be tank mixed with sima-
zine; or simazine may be applied just before or
after any metolachlor treatment to those field and
liner grown ornamentals marked with an asterisk.
(Noncrop,- Wide Area, and General Indoor/Outdoor Treatments)
Highway Rights-of-Way N.F.
[MAI]
1.25
(2.5 Ib/gal, 3.3
Ib/gal F1C)
.Railroad Rights-of-
Way
(8 Ib/gal EC)
Use limited to CO, KS, MT, NE, ND, SD, and WY.
Broadcast for weed control in established peren-
nial grasses along roadsides. Apply in the fall
before ground freezes, or after thawing in the
spring. Apply only once per year.
Formulated with atrazine.
N.F.
Broadcast. Apply immediately prior to weed emer-
gence in 50 to 100 gallons of water per acre. The
tank mix with atrazine may be applied after weeds
emerge, but before they reach 6 inches in height.
Tank mix with atrazine; or simazine.
Issued: 2/21/86
1-108801-15
1 12
-------
EPA Index to Pesticide Chemicals
METOLACHLOR
Listing of Registered Pesticide Products by Formulation
095.0001 95% technical chemical
metolachlor U0880U
000100-00587
&015.0004
&025.0004
4286.4012
&227.5014
231.8014
15% granular
metolachlor (108801)
000100-00627
25% granular
metolachlor (108801)
000100-00638
86.4% (8 Ib/gal) emulsiftable concentrate
metolachlor 1108801)
000100-00597 000100-00610
(000100-00597)
A283000500
MD79001000
IA79000500
NM85000400
IA83000100
TX83001100
27.5% (2.5 Ib/gal) flowable concentrate
metolachlor (108801) plus atrazine (080803)
000100-00590
(000100-00590)
IA83000200 OK82002900
31.8% (2.9 Ib/gal) flowable concentrate
metolachlor (108801) plus atrazine (080803)
000100-00623
&236.1014 36.IX • (3:3 - Ib/gal)-flowable concentrate
&236.3014
metolachlor (108801) plus atrazine (080803)
000100-00645
36.3% (3.3 Ib/gal) flowable concentrate
metolachlor (108801) plus propazine (080808)
000100-00604
Issued: 2/21/86
1-108801-16
113
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EPA Index to Pesticide Chemicals
METOLACHLOK
Appendix A-l
Listing of Active Ingredient(s) Found in Combination With the Report Chemic;
Chemical Common Name EPA Acceptable
Code (source) Common/Chemical Name
080803 — atrazine
080808 — propazine
— Use EPA Acceptable Common/Chemical Name
Issued: 2/21/86 1-108801-17
114
-------
Listing of
Chemical
Code
101101
080803
084301
029901
100101
029801
030001
037505
037512
041401
108501
103601
035506
061601
080805
080808
041404
080807
030703
080813
EPA Index to Pesticide Chemicals
METOLACHLOK
Appendix A-2
Active Ingredient(s) Which May Be Included in Tank Mixes
Common Name
(source)
metribuzin
benfluralin (ISO)
cyanazine (ISO)
2,4-D
EPIC
EPA Acceptable
Common/Chemical Name
4-amino-6-(l,l-dimethylethyl)-3-(methyl-
thio)-l,2,4-triazin-5(4H)-one
atrazine
N-buty1-N-ethy1-alpha,alpha,alpha-tri-
fluoro-2,6-dinitro-p-toluidine
chloramben
2-[[4-chloro-6-(ethylamino)-S-triazin-2-
yl]-amino]-2-methyl propionitrile
dicamba
2,4-dichlorophenoxyacetic acid
dinoseb
dinoseb, sodium salt
S-ethyl dipropylthiocarbamate
pendimethalin (ANSI) N-(l-ethylpropyl)-3,4-dimethyl-2,6-dini-
trobenzenamine
glyphosate
paraquat
vernam
glyphosate, isopropylamine, salt of
tlinuron
•»
paraquat dichloride
prometryn
propazine
S-propyl dipropylthiocarbamate
simazine
sodium N-1-naphthylphthalamate. .
terbutryn
Issued: 2/21/86
1-108801-18
115
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EPA Index to Pesticide Chemicals
METOLACHLOR
Appendix A-2
Listing of Active Ingredient(s) Which May Be Included in Tank Mixes
(continued)
Chemical Common Name EPA Acceptable
Code (source) Common/Chemical Name
036101 — trifluralin
— Use EPA Acceptable Common/Chemical Name
Issued: 2/21/66 1-108801-19
116
-------
EPA Index to Pesticide Chemicals
METOLACHLOR
Auxiliary Documentation
#100-645 (Bicep 6L) has a 2.64-3.55 Ib a.i.'/A dosage range for sorghum
(from table 5), which is much higher than the "normal" rate of 1.5-2 Ib
a.i./A. I did not extend the entry's dosages to reflect this rate.
#100-597 (dual 8E) in the paragraph dealing with soybean tank mix/sequen-
tial application with metribuzin, they refer to a table 5 for dosages. 1
assumed table 7 to be the correct one and used it for the dosage calcula-
tion.
#100-638 (dual 25G) in the soybean, reduced-till, preplant surface appli-
cation, does not give a dosage rate. The later mention of "2 Ib a.i./A"
on coarse soils not more than 2 weeks prior to planting" coincides with
the dual 8E label; it's the medium and fine texture soil dosages that were
lacking. I assumed 2-3 Ib a.i./A to be the complete coarse to fine dosage
range as was on the dual 8E label. Table 3 is not likely to be intended
for this use because the coarse soil rate of 2 Ib a.i./A is higher than
the lowest rate in table 3; this coincides with other no-till vs. conven-
tional till rates elsewhere in the labeling.
#100-597 (dual 8E) in final soybean use for no-till with metribuzin or
linuron and paraquat O£ glyphosate, does not specify application timing.
I assumed both preplant and preemergence.
117
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APPENDIX IV
BIBLIOGRAPHY APPENDICES
118
-------
APPENDIX IV
GUIDE TO USE OP THIS BIBLIOGRAPHY
1. CONTENT OP BIBLIOGRAPHY. This bibliography contains
citations of all studies considered relevant by EPA in
arriving at the positions and conclusions stated elsewhere
in the Standard. Primary sources for studies in this
bibliography have been the body of data submitted to EPA
and its predecessor agencies in support of past regulatory
decisions. Selections from other sources including the
published literature, in those instances where they have
been considered, will be included.
2. UNITS OP ENTRY. The unit of entry in this bibliography
is called a "study." In the case of published materials,
this corresponds closely to an article. In the case of
unpublished materials submitted to the Agency, the Agency
has sought to Identify documents at a level parallel to
the published article from within the typically larger
volumes In which they were submitted. The resulting
"studies" generally have a distinct title (or at least a
.single subject), can stand alone for purposes of review,
and c:an be described with a conventional bibliographic
citation. The Agency has attempted also.to unite basic
documents and commentaries upon them, treating them as a
single study.
3. IDENTIFICATION OP ENTRIES. The entries in this bibliography
are sorted numerically by "Master Record Identifier," or
MRID, number. This number is unique to the citation, and
should be used at any time specific reference is required.
It is not related to the six-digit "Accession Number"
which has been used to identify volumes of submitted
studies; see paragraph 4(d)(4) below.for a further explana-
tion. In a few cases, entries added to the bibliography
late in the review may be preceded by a nine-character
temporary identifier. These entries are listed after
all MRID entries. This temporary identifier number Is
also to be used whenever specific reference is needed.
H. FORM OP ENTRY. In addition to the Master Record Identifier
(MRID), each entry consists of a citation containing
standard elements followed, in the case of material
submitted to EPA, by a description of the earliest known
submission. Bibliographic conventions used reflect the
standards of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
119
-------
a. Author. Whenever the Agency could confidently identify
one, the Agency has chosen to show a personal author.
When no individual was Identified, the Agency has
shown an Identifiable laboratory or testing facility
as author. As a last resort, the Agency has shown
the first submitter as author.
b. Document Date. When the date appears as four digits
with no question marks, the Agency took it directly
from the document. When a four-digit date is followed
by a question mark, the bibliographer deduced the
date from evidence in the document. When the date
appears as (19??), the Agency was unable to determine
or estimate the date of the document.
c. Title. In some cases, it has been necessary for
Agency bibliographers to create or enhance a document
title. Any such editorial insertions are contained
between square brackets.
d. Trailing Parentheses. For studies submitted to the
Agency in the past, the trailing parentheses include
(in addition to any self-explanatory text) the fol-
lowing elements describing the earliest known submission:
(1) Submission Date. The date of the earliest known
submission appears immediately following the word
"received."
(2) Administrative Number. The next element,
immediately following the word "under," is the
registration number, experimental use permit
number, petition number, or other administrative
number associated with the earliest known submission.
(3) Submitter. The third element is the submitter,
following the phrase "submitted by." When
authorship is defaulted to the submitter, this
element is omitted.
(4) Volume Identification (Accession Numbers). The
final element in the trailing parentheses
identifies the EPA accession number of the volume
in which the original submission of the study
appears. The six-digit accession number follows
the symbol "CDL," standing for "Company Data
Library." This accession number is in turn
followed by an alphabetic suffix which shows the
relative position of the study within the volume.
For example, within accession number 123456, the
first study would be 123456-A; the second, 123456-
B; the 26th, 123456-Z; and the 27th, 123456-AA.
120
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015396 Fritz, H. (1976) Reproduction Study: CGA 24705 Tech.: Rat: Seg. II.
(Unpublished study including addendum, received Jan 19, 1977 un-
der 100-583; prepared by Ciba-Geigy, Ltd., submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:095768-E)
00015397 Ami, P.; Muller, D. (1976) Salmonella/Mammalian—Microsome Muta-
genicity Test. (Unpublished study received Jan 19, 1977 under
100-583; prepared by Ciba-Geigy, Ltd., submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:095768-F)
00015399 Seim, V. (1975) Residue Report: Soybeans: AG-A No. 3268 1,11,III.
(Unpublished study received Jan 19, 1977 under 100-583; submit-
ted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:095747-A)
00015400 Peek, J.; Stahlberg, L. (1975) Residue Report: Soybeans: AG-A
No. 3466 I,II. (Unpublished study received Jan 19, 1977 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
.095747-8)
00015401 Roper, J. (1975) Residue Report: Soybeans: AG-A No. 3523 I,II,III.
(Unpublished study received Jan 19, 1977 under 100-583; submit-
ted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:095747-C)
00015402 Juby, M. (1975) Residue Report: Soybeans: AG-A No. 3570 1,11,111.
(Unpublished study received Jan 19, 1977 under 100-583; submit-
ted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:095747-D)
00015403 Pruss, S.; Ross, R.H. (1976) Residue Report: Soybeans: AG-A
No. 3650 III. (Unpublished study received Jan 19, 1977 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
095747-E)
00015404 Peek, J.; Stahlberg, L. (1976) Residue Report: Soybeans: AG-A
No. 3702 III. (Unpublished study received Jan 19, 1977 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
095747-F)
00015405 Shriver, J.; Uendling, C. (1976) Residue Report: Soybeans: AG-A
No. 3724 III. (Unpublished study including AG-A nos. 3742 II,
3743 II and 3747 II, received Jan 19, 1977 under 100-583; pre-
pared in cooperation with Chemagro and E.I. du Pont de Nemours
and Co., submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
095747-G)
00015406 Gaspard, J. (1976) Residue Report: Soybeans: AG-A No. 3758 II.
(Unpublished study received Jan 19, 1977 under 100-583; prepared
in cooperation with Chemagro, submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:095747-K)
121
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015407 Westmoreland, VI.G. (1976) Residue Report: Soybeans: AG-A
No. 3764 II. (Unpublished study received Jan 19, 1977 under
100-583; prepared in cooperation with Chemagro, submitted by
Ciba-Geigy Corp., Greensboro, N.C.; CDL:095747-L)
00015408 Pruss, S.W.; Schnappinger, M.G. (1976) Residue Report: Soybeans:
AG-A No. 3775 II. (Unpublished study including AG-A no. 3776
II, received Jan 19, 1977 under 100-583; prepared in cooperation
with E.I. du Pont de Nemours and Co., submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:095747-M)
00015409 Peek, J.; Stahlberg, L. (1976) Residue Report: Soybeans: AG-A
No. 3778 II. (Unpublished study including AG-A nos. 3780 II and
3782 II, received Jan 19, 1977 under 100-583; prepared in co-
operation with Chemagro and E.I. du Pont de Nemours and Co.,
submitted by Ciba-Geigy Corp., breensboro, N.C.; CDL:095747-0)
00015410 Thomas, J.; Herman, D. (1976) Residue Report: Soybeans: AG-A
No. 3803 II. (Unpublished study including AG-A no. 3812 II, re-
ceived Jan 19, 1977 under 100-583; prepared in cooperation with
E.I. du Pont de Nemours & Co., submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:095747-R)
00015411 Pruss, S.W.; Luke, J.E. (1976) Residue Report: Soybeans: AG-A
No. 3885. (Unpublished study received Jan 19, 1977 under 100-
583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
095747-T)
00015413 Mattson, A.M. (1975) CGA-24705 Residues in Milk, Meat, Eggs and
Chickens (Three Level Feeding Studies): Report No. GAAC-75059.
(Unpublished study received Jan 19, 1977 under 100-583; submit-
ted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:095747-X)
00015418 Gordon, D.E. (1978) Two-Year Chronic Oral Toxicity Study—Albino
Rats: IBT No. 8532-07926. (Unpublished study received Jul 7,
1978 under 100-583; prepared by Industrial Bio-Test Laborato-
ries, Inc., submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:097168-D)
00015423 Sumner, D.D.; Thomas, R.D.; Cassidy, J.E. (1975) Structure Elucida-
tion of the Metabolites of CGA-24705 in Corn: M4-68-2Y: Report
No. GAAC-75012. (Unpublished study received Mar 26, 1975 under
5F1606; submitted by Ciba-Geigy torp.* Sreensboro, N.C.; CDL:
094378-F)
122
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015424 Gross, D. (1974) Uptake, Translocation annd Degradation of CGA
24 705 in Corn Grown Under Controlled Conditions: Project Report
No. 13/74: Addendum to Project Report No. 8/74. (Unpublished
study received Mar 26, 1975 under 5F1606; prepared by Ciba-
Geigy, Ltd., submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:094378-H)
00015425 Hambock, H. (1974) Metabolism of CGA 24 705 in the Rat: Project Re-
port 12/74: Addendum to Project Report 7/74, (Unpublished study
received Mar 26, 1975 under 5F1606; prepared by Ciba-Geigy,
Ltd., submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
094378-0)
00015428 Kincaid, L. (1975) Residue Report: Field Corn: AG-A No. 3383. (Un-
published study received Mar 26, 1975 under 5F1606; submitted by
Ciba-Geigy Corp., Greensboro, N.C.; CDL:094379-0)
00015429 Thomas, J.; Herman, 0. (1975) Residue Report: Field Corn: AG-A
'..."•: No. 3501 I,II. (Unpublished study received Mar 26, 1975 under
5F1606; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
094379-P)
00015430 Kincaid, L. (1975) Residue Report: Sweet Corn: AG-A No. 3446. (Un-
published study received Mar 26, 1975 under 5F1606; submitted by
Ciba-Geigy Corp., Greensboro, N.C.; CDL:094379-T)
00015432 Ramsteiner, K.; Karlhuber, B. (1975) CGA 24705: Determination of
Total Residue in Material of Animal Origin. Method no. REM 2/75
dated Feb 6, 1975. (Unpublished study received Mar 26, 1975
under 5F1606; prepared by Ciba-Geigy, Ltd., submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:094379-AJ)
00015466 Aziz, S.A.; Ross, J.A. (1975) Analytical Method for the Determina-
tion of Residues of CGA-24705 Soybean Metabolites as CGA-37913
and CGA-49751 by Acid Hydrolysis. Method no. AG-286 dated Jun
10, 1975. (Unpublished study received Nov 25, 1975 under
6G1708; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
094877-S)
00015469 Gold, B.; Kahrs, R.A. (1975) Freezer Storage Stability of CGA-24705
Residues in Corn Fodder and Grain: Report No. GAAC-75062. (Un-
published study received Nov 25, 1975 under 6G1708; submitted by
Ciba-Geigy Corp., Greensboro, N.C.; CDL:094877-X)
00015523 Bathe, R. (1973) Acute Oral LD50 of Technical CGA-24705 in the
Rat: Project No. Siss 2979. (Unpublished study received Mar 1,
1974 under 5G1553; prepared by Ciba-Geigy, Ltd., submitted by
Ciba-Geigy Corp., Greensboro, N.C.; CDL:094220-B)
123
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015526 Bach, K.J. (1974) Acute Dermal LD50 Test in Rabbits: Contract
No. 120-2255-34. (Unpublished study received on unknown date
under 5G1553; prepared by Affiliated Medical Research, Inc.,
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:094220-E)
00015530 Sachsse, K. (1973) Skin Irritation in the Rabbit after Single Ap-
plication of Technical CGA-24705: Project No. Siss 2979. (Un-
published study received Mar 1, 1974 under 5G1553; prepared by
Ciba-Geigy, Ltd., submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:094220-I)
00015535 Sachsse, K.; Ullmann, L. (1974) Acute Inhalation Toxicity of Tech-
nical CGA-24705 in the Rat: Project No. Siss 3516. (Unpublished
study received on unknown date under 5G1553; prepared by Ciba-
Geigy, Ltd., submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:094220-N)
0001553& Newby, L. (1979) Dual Rotational Studies: Additional Informa-
tion: Report No. ABR-79091. (Unpublished study received Aug 1,
1979 under 100-583; submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:238899-A)
00015540 Ross, R.H. (1979) Metolachlor (Dual 8E); Chloramben (Amiben
2E): AG-A No. 5173 I,II. (Unpublished study including letter
dated May 8, 1979 from S.L. Harrison to Warren A. Davis, re-
ceived Jun 20, 1979 under 100-583; prepared in cooperation with
AM-CHEM Products, Inc. and Union Carbide Agricultural Products
Co., Inc., submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:238677-B)
00015541 Kern, C.L. (1979) Metolachlor (Dual 8E); Chloramben (A-niben
2SL): AG-A No. 5218 1,11. (Unpublished study including letter
dated May 8, 1979 from S.L. Harrison to Warren A. Davis, re-
ceived Jun 20, 1979 under 100-583; prepared in cooperation with
AM-CHEM Products, Inc. and Union Carbide Agricultural Products
Co., Inc., submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
238677-C)
00015542 Rose, W.; Clapp, T.; Clapp, G. (1979) Metolachlor (Dual 8E);
Chloramben (Amiben 2E): AG-A No. 5341. (Unpublished study in-
cluding letter dated May 8, 1979 from S.L. Harrison to Warren A.
Davis, received Jun 20, 1979 under 100-583; prepared in coopera-
tion with AM-CHEM Products, Inc. and Union Carbide Agricultural
Products Co., Inc., submitted by Ciba-Geigy Corp., Greensboro,
N.C.; JCDL:238677-D)
124
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015543 Cargile, N.L.; Ross, J.A. (1979) Analytical Method for Residues of
Metolachlor Plant Metabolites Determined as CGA-37913 and CGA-
49751 after Acid Hydrolysis. Method no. AG-338 dated Apr 23,
1979. (Unpublished study received Jun 20, 1979 under 100-583;
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:238677-F)
00015546 Vilkas, A.G. (1976) Acute Toxicity of CGA-24705 Technical to the
Water Flea, Daphnia magna Straus. (Unpublished study received
Nov 24, 1976 under 100-587; prepared by Union Carbide Corp.,
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:226955-E)
00015548 Houseworth, L.D.; Rolla, H. (1977) Residues of Metolachlor in or on
Sorghum Resulting from Preplant Incorporated and Preemergence
Applications: Report No. ABR-77086. (Unpublished study received
Nov 14, 1977 under 8G2019; submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:096625-A)
00015549 Ragsdale, D.; Peek, J. (1977) Residue Report: Sorghum: AG-A
''..."•:-•- No. 4413 Third Report. (Unpublished study received Nov 14, 1977
under 8G2019; submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:096626-A)
00015550 Thomas, J.; Herman, D. (1977) Residue Report: Sorghum: AG-A
No. 4418 Third Report. (Unpublished study received Nov 14, 1977
under 8G2019; submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:096626-B)
00015551 Turner, W.E. (1977) Residue Report: Sorghum: AG-A No. 4503 Third
Report. (Unpublished study received Nov 14, 1977 under 8G2019;
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:096626-C)
00015552 Holt, B.E. (1977) Residue Report: AG-A No. 4753. (Unpublished
study received Nov 14, 1977 under 8G2019; submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:096626-D)
00015553 Kahrs, R.A. (1979) Residues of Metolachlor in Peanuts Resulting
from Preplant Incorporated or Preemergence Applications: Report
No. ABR-79059. Summary of studies 098298-B, 098298-C, 098298-F,
098298-1 and 098298-J. (Unpublished study received May 18, 1979
under 100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:098298-A)
00015554 Rose, W.; Coble, H. (1979) Metolachlor (Dual 8E), Naptalam + DNBP
(Dyanap 3E): AG-A No. 4715 1,11. (Unpublished study received
May 18, 1979 under 100-583; prepared in cooperation with IRDC,
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:098298-B)
125
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015555 Dill, R. (1979) Residue Report: Peanuts: AG-A No. 4742 II. (Unpub-
lished study received May 18, 1979 under 100-583; prepared in
cooperation with IRDC, submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:098298-C)
00015556 McMahon, A. (1979) Residue Report: Peanuts: AG-A No. 4840 II. (Un-
published study received May 18, 1979 under 100-583; submitted
by Ciba-Geigy Corp., Greensboro, N.C.*; CDL:098298-F)
00015557 McMahon, A. (1979) Metolachlor (Dual 8E): AG-A No. 4841 I,II.
(Unpublished study received May 18, 1979 under 100-583; submit-
ted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:098298-I)
00015570 Taylor, D.; Shriver, J.; Guthrie, C. (1976) Residue Report: Field
Corn: AG-A No. 3372 II. (Unpublished study received Jun 20,
1977 under 100-590; submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:230685-E)
.00015571 Seim, V. (1976) Residue Report: Field Corn: AG-A No. 3674 II,III.
(Unpublished study received Jun 20, 1977 under 100-590; submit-
ted by Ciba-Geigy Coorp., Greensboro, N.C.; COL:230685-G)
00015572 Chamberlain, E.; Shriver, J.; Wendling, C. (1976) Residue Report:
Field Corn: AG-A NO. 3745 I,II,III. (Unpublished study received
Jun 20, 1977 under 100-590; submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:230685-H)
00015586 Houseworth, L.D. (1978) Residues of Metolachlor and Atrazine in or
on Corn Resulting from the Application of Metolachlor, Metola-
chlor/ Atrazine Tank Mixes or a Metolachlor/Atrazine Pre-pack
through Center Pivot Irrigation Systems: Report No. ABR-78074.
Summary of studies 235358-B through 235358-J. (Unpublished
study received Oct 20, 1978 under 100-583; submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:235358-A)
00015587 Stahlberg, L. (1978) Metolachlor (Dual 8E): AG-A No. 4870 I,
II. (Unpublished study received Oct 20, 1978 under 100-583;
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:235358-B)
00015588 Turner, W.E.; Wiese, A.F. (1978) Metolachlor (Dual 8E): AG-A
No. 4908 I,II. (Unpublished study received Oct 20, 1978 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
235358-C)
00015589 Threewitt, T. (1978) Metolachlor (Dual 8E): AG-A No. 4929 I,
II. (Unpublished study received Oct 20, 1978 under 100-583;
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:235358-D)
126
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015590 Stahlberg, L. (1978) Metolachlor + Atrazine; Dual 8E + Aa-
trex 4L: AG-A No. 4871 I,II. (Unpublished study received
Oct 20, 1978 under 100-583; submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDU235358-E)
00015591 Stahlberg, L. (1978) Metolachlor + Atrazine (Bicep 4.5L): AG-A
No. 4872 I,II. (Unpublished study received Oct 20, 1978 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
235358-F)
00015592 Turner, W.E.; Wiese, A.F. (1978) Metolachlor + Atrazine, Dual
8E + Aatrex 4L: AG-A No. 4909 I.I I. (Unpublished study re-
ceived Oct 20, 1978 under 100-583; submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:235358-G)
00015593 Turner, W.E.; Wiese, A.F. (1978) Metolachlor + Atrazine (Bicep
4.5L): AG-A No. 4910 I,II. (Unpublished study received Oct 20,
1978 under 100-583; submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:235358-H)
00015594 Threewitt, T. (1978) Metolachlor + Atrazine (Dual 8E + Aa-
trex SOW): AG-A No. 4930 1,11. (Unpublished study received
Oct 20, 1978 under 100-583; submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:235358-I)
00015595 Threewitt, T. (1978) Metolachlor + Atrazine (Bicep 4.5L): AG-A
No. 4931 1,11. (Unpublished study received Oct 20, 1978 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
235358-J)
00015597 Buchholz, C. (1978) Metolachlor (Dual 8E); Cyanazine (Bla-
dex SOW): AG-A No. 4752 1,11. (Unpublished study received
Oct 20, 1978 under 100-583; prepared in cooperation with Shell
Chemical Co., submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:235359-B)
00015598 Rose, W.; Monaco, T. (1978) Metolachlor (Dual 8E); Cyanazine
(Bladex 4WDS): AG-A No. 4810. (Unpublished study received
Oct 20, 1978 under 100-583; prepared in cooperation with Shell
Chemical Co., submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:235359-C)
00015599 Turner, W. (1978) Metolachlor (Dual 8E); Cyanazine (Bladex
SOW); Cyanazine (Bladex 4WDS): AG-A No. 4864 1,11. (Unpublished
study received Oct 20, 1978 under 100-583; prepared in coopera-
tion with Shell Chemical Co., submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:235359-D)
127
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015600 Stahlberg, L. (1978) Metolachlor (Dual 8E); Cyanazine (Bladex SOW):
AG-A No. 4875 1,11. (Unpublished study received Oct 20, 1978
under 100-583; prepared in cooperation with Shell Chemical Co.,
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:235359-E)
00015601 Clarkson, V. (1978) Metolachlor (Dual 8E); Cyanazine (Bladex SOW):
AG-A No. 4972 I,II. (Unpublished study received Oct 20, 1978
under 100-583; prepared in cooperation with Shell Chemical Co.,
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:235359-F)
00015602 Wustner, D.A. (1978) Metolachlor (Dual 3E); Cyanazine (Bla-
dex 4L): AG-A No. 6013. (Unpublished study received Oct
20, 1978 under 100-583; prepared in cooperation with Shell Oil
Co., submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
235359-G)
00015630 Fritz, H. (1976) Dominant Lethal Study on CGA 24705 Technical:
- - Mouse: Test for Cytotoxic or Mutagenic Effects on Male Germinal
Cells. (Unpublished study including addendum, received Jan 18,
1978 under 100-583; prepared by Ciba-Geigy, Ltd., submitted by
Ciba-Geigy Corp., Greensboro, N.C.; .CDL:096717-E)
00015631 Sachsse, K.; Ullmann, L. (1977) Skin Sensitizing (Contact Allergen-
ic) Effect in Guinea Pigs of Technical CGA 24705: Project
No. Siss 5726. (Unpublished study received Jan 18, 1978 under
100-583; prepared by Ciba-Geigy, Ltd., submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:096717-F)
00015652 Sumner, D.D.; Cassidy, J.E. (1974) The Metabolism of CGA-24705 in
Corn: Report No. GAAC-74050. (Unpublished study received Sep
26, 1974 under 5G1553; submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:094217-D)
00015653 Gross, D. (1974) Uptake, Translocation and Degradation of CGA
24 705 in Corn Grown under Controlled Conditions: Project Report
No. 8/74. (Unpublished study received Sep 26, 1974 under
5G1553; prepared by Ciba-Geigy, Ltd., submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:094217-F)
00015656 Dupre, G.D. (1974) Abbreviated Anaerobic Metabolism of 14C-CGA-
24705 in Silt Loam Soil under Greenhouse Conditions: Report
No. 73019-3. (Unpublished study received Sep 26, 1974 under
5G1553; prepared by Bio/dynamics, Inc., submitted by C1ba-Geigy
Corp., Greensboro, N.C.; CDL:094222-B)
128
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015695 Mattson, A.M. (1974) CGA-24705 Residues in Milk, Meat, Eggs and
Chickens (Three Level Feeding Studies): Report No. GAAC-74064.
(Unpublished study received Sep 26, 1974 under 5G1553; submitted
by Ciba-Geigy Corp., Greensboro, N.C.; CDL:094216-W)
00015696 Schenker, M.; Holzhauer, ?; Merlini, ?; et al. (1974) CGA 24705:
Total Residues in Milk and Tissues of Swiss Cows: No. RVA 81/74.
(Unpublished study received Sep 26, 1974 under 5G1553; prepared
by Ciba-Geigy, Ltd., submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:094216-X)
00015697 Guth, J.; Arnet, M.; Imhof, P.; et al. (1974) CGA 24705: Total Res-
idues in Chicken Tissues and Eggs, 1974: No. RVA 88/74. (Unpub-
lished study including no. RVA 02/75, received Sep 26, 1974
under 5G1553; prepared by Ciba-Geigy, Ltd., submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:094216-Y)
00015698 Hermann, W.D.; Guth, J.A.; Formica, G.; et al. (1974) CGA 24705:
- Gas Chromatographic Determination of Total Residues in Material
of Animal Origin (Provisional). Method no. REM 5/74. dated Jun
26, 1974. (Unpublished study received Sep 26, 1974 under
5G1553; prepared by Ciba-Geigy, Ltd., submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:094216-Z)
00015704 Juby, M. (1974) Residue Report: Field Corn: AG^A No. 3328. (Unpub-
lished study received Sep 26, 1974 under 5G1553; submitted by
Ciba-Geigy Corp., Greensboro, N.C.; CDL:094216-AK)
00015705 Kern, C.L. (1974) Residue Report: Field Corn: AG-A No. 3326. (Un-
published study received Sep 26, 1974 under 5G1553; submitted by
Ciba-Geigy Corp., Greensboro, N.C.; CDL:094216-AL)
00015706 Kahrs, R.A. (1978) Summary: Residue Chemistry Data to Establish
Tolerances for Residues of Metolachlor in Corn Forage and
Fodder, Soybean Forage and Fodder, and Fresh Corn, including
Sweet Corn (Kernels plus Cobs, Husks Removed): Report No. ABR-
78028. Summary of studies 094216-B, 094216-C, 094216-E through
094216-K, 094216-M, 094216-N, 094216-P through 094216-V,
094216-AK, 094216-AL, 094379-D, 094379-0, 094379-P, 094379-T,
094379-AB, 097134-Q, 097134-S, 097134-X, 097134-AE through
097134-AI, 097134-AO through 097134-AT, 228126-E through
228126-H, 228126-J, 230685-G, and 230685-H. (Unpublished study
received May 11, 1978 under 100-583; submitted by Ciba-Geigy
Corp*, greensboro, N.C.j CDL:097133-A)
131
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015707 Snow, J.G.; Tinklepaugh, ? (1976) Residue Report: Field Corn: AG-A
No. 3799 II,III. (Unpublished study received May 11, 1978 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
097134-S)
00015708 Ross, R.H. (1978) Metolachlor (Dual 8E): AG-A No. 4855 I,II,
Second Report. (Unpublished study received May 11, 1978 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
097134-AE)
00015709 Turner, W.E. (1978) Metolachlor (Dual 8E): AG-A No. 4860 I,II
Second Report. (Unpublished study received May 11, 1978 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
097134-AF)
00015710 Stahlberg, L. (1978) Metolachlor (Dual 8E): AG-A No. 4873 I,
II, 2nd Report. (Unpublished study received May 11, 1978 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
097134-AG)
00015711 Turner, W.E. (1978) Metolachlor + Atrazine (Dual 8E + AA-
trex 4L): AG-A No. 4861 I,II Second Report. (Unpublished
study received May 11, 1978 under 100-583; submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:097134-AH)
00015712 Stahlberg, L. (1978) Metolachlor + Atrazine (Dual 8E + AA-
trex 4L): AG-A No. 4874 I,II Second Report. (Unpublished
study received May 11, 1978 under 100-583; submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:097134-AI)
00015713 Buchholz, C. (1978) Metolachlor (Dual 8E): AG-A No. 4749 I, II.
(Unpublished study received May 11, 1978 under 100-583; sub-
mitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:097134-AO)
00015714 Rose, W.E.; Monaco, T. (1978) Metolachlor (Dual 8E): AG-A
No. 4806. (Unpublished study received May 11, 1978 under 100-
583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
097134-AP)
00015715 Clarkson, V. (1978) Metolachlor (Dual 8E): AG-A No. 4974.
(Unpublished study received May 11, 1978 under 100-583; sub-
mitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:097134-AQ)
00015716 Buchholr, C. (1978) Metolachlor + Atrazine (Dual 8E) + (AA-
trex SOW): AG-A No. 4748 I, II. (Unpublished study re-
ceived May 11, 1978 under 100-583; submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:097134-AR)
132
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015717 Rose, W.; Monaco, T. (1978) Metolachlor + Atrazine (Dual 8E) +
(AAtrex 4L): AG-A No. 4807. (Unpublished study received
May 11, 1978 under 100-583; submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:097134-AS)
00015718 Clarkson, V. (1978) Metolachlor, Atrazine (Dual 8E, AA-
trey SOW): AG-A No. 4975. (Unpublished study received May
11, 1978 under 100-583; submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:097134-AT)
00015719 Ross, R.H.; Pruss, S. (1976) Residue Report: Soybeans: AG-A
No. 3650 1,11. (Unpublished study received May 11, 1978 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
097135-A)
00015721 Shriver, J.; Wendling, C. (1976) Residue Report: Soybeans: AG-A
No. 3747 II. 2nd Report. (Unpublished study received May 11,
1978 under 100-583; submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:097135-D)
00015722 Pruss, S.; Schnappinger, M.G. (1976) Residue Report: Soybeans: AG-A
No. 3775 II. 2nd report. (Unpublished study received May 11,
1978 under 100-583; submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:097135-E)
00015723 Peek, J.; Stahlberg, L. (1976) Residue Report: Soybeans: AG-A
No. 3782. (Unpublished study received May 11, 1978 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:097135-F)
00015725 Pruss, S.W.; Luke, J.E. (1976) Residue Report: Soybeans: AG-A
No. 3885. 2nd Report. (Unpublished study received May 11,
1978 under 100-583; submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:097135-H)
00015726 Richards, R.F. (1976) Residue Report: Soybeans: AG-A No. 3948. 2nd
Report. (Unpublished study received May 11, 1978 under 100-583;
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:097135-I)
00015727 Shriver, J.; Wendling, C. (1976) Residue Report: Soybeans: AG-A
No. 3743. (Unpublished study received May 11, 1978 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:097135-J)
00015728 Schnappinger, M.G.; Pruss, S.W. (1976) Residue Report: Soybeans:
AG-A No. 3776. (Unpublished study received May 11, 1978
.under 100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:097135-K)
133
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015729 Peek, J.; Stahlberg, L. (1976) Residue Report: Soybeans: AG-A
No. 3780. (Unpublished study received May 11, 1978 under 100-
583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
097135-L)
00015731 Shriver, J.; Wendling, C. (1977) Residue Report: Soybeans: AG-A
No. 3742. (Unpublished study received May 11, 1978 under 100-
583; prepared in cooperation with Mobay Chemical Corp. and Ana-
lytical Biochemistry Laboratories, submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:097135-0)
00015732 Gaspard, J.T. (1977) Residue Report: Soybeans: AG-A No. 3758. (Un-
published study received May 11, 1978 under 100-583; prepared in
cooperation with Mobay Chemical Corp. and Analytical Biochemis-
try Laboratories, submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:097135-P)
00015731 Westmoreland, W.G. (1977) Residue Report: Soybeans: AG-A No. 3764.
(Unpublished study received May 11, 1978 under 100-583; prepared
in cooperation with Mobay Chemical Corp. and Analytical Biochem-
istry Laboratories, submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:097135-Q)
00015734 Peek, J.; Stahlberg, L. (1977) Residue Report: Soybeans: AG-A
No. 3778. (Unpublished study received May 11, 1978 under 100-
583; prepared in cooperation with Mobay Chemical Corp. and Ana-
lytical Biochemistry Laboratories, submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:097135-R)
00015735 Luke, J. (1978).Metolachlor (Dual 8E): AG-A No. 4737 1,11.
(Unpublished study received May 11, 1978 under 100-583; sub-
mitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:097135-T)
00015736 Kern, C. (1978) Metolachlor (Dual 8E): AG-A No. 4781 I,II.
(Unpublished study received May 11, 1978 under 100-583; sub-
mitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:097135-U)
00015737 Herman, D. (1978) Metolachlor (Dual 8E): AG-A No. 4986 1,11.
(Unpublished study received May 11, 1978 under 100-583; sub-
mitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:097135-V)
00015739 Chamberlain, E.; Stahlberg, L. (1978) Metolachlor (Dual 8E); Atra-
zine (AAtrex SOW & 4L): AG-A No. 4790 1,11,1II. (Unpublished
study received Mar 16, 1979 under 100-583; prepared in coopera-
tion with EN-CAS Laboratories, submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:237817-B)
134
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015740 Luke, J.E. (1978) Metolachlor (Dual 8E); Atrazine (AAtrex SOW +
4L): AG-A No. 4811 I,II,III. (Unpublished study received Mar
16, 1979 under 100-583; prepared in cooperation with EN-CAS An-
alytical Laboratories, submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:237817-C)
00015741 Turner, W.E. (1978) Metolachlor (Dual 8E); Atrazine (AA-
trex 4L): AG-A No. 4862 1,11. (Unpublished study received
Mar 16, 1979 under 100-583; prepared in cooperation with Texas
Agricultural Experiment Station and EN-CAS Analytical Laborato-
ries, submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
237817-D)
00015742 Dorr, J.; Buchholz, C. (1978) Metolachlor (Dual 6E); Atrazine (AA-
.trex 4L): AG-A No. 4750 I,II. (Unpublished study received Mar
16, 1979 under 100-583; prepared in cooperation with EN-CAS An-
alytical Laboratories, submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:237817-E)
00015743 Chamberlain, E.; Stahlberg, L. (1978) Metolachlor (Dual 8E);
Atrazine (AAtrex SOW): AG-A No. 4791. (Unpublished study
received Mar 16, 1979 under 100-583; prepared in cooperation
with EN-CAS Analytical Laboratories, submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:237817-F)
00015744 Rose, W.; Monaco, T. (1978) Metolachlor (Dual 8E); Atrazine (AA-
trex 4L): AG-A No. 4808. (Unpublished study received Mar 16,
1979 under 100-583; prepared in cooperation with EN-CAS Analyti-
cal Laboratories, submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:237817-G)
00015745 Chamberlain, E.; Stahlberg, L. (1978) Metolachlor + Atrazine (Bi-
cep 4.5L): AG-A No. 4792 1,11,111. (Unpublished study received
Mar 16, 1979 under 100-583; prepared in cooperation with EN-CAS
Analytical Laboratories, submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:237817-H)
00015746 Luke, J.E. (1978) Metolachlor + Atrazine (Bicep 4.5L): AG-A
No. 4812 1,11,111. (Unpublished study received Mar 16, 1979
under 100-583; prepared in cooperation with EN-CAS Analytical
Laboratories, submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:237817-I)
00015747 Turner, W.E. (1978) Metolachlor + Atrazine (Bicep 4.5L): AG-A
No. 4863 1,11. (Unpublished study received Mar 16, 1979 under
100-583; prepared in cooperation with Texas Agricultural Experi-
ment Station and EN-CAS Analytical Laboratories, submitted by
Ciba-Geigy Corp., Greensboro, N.C.; CDL:237817-J)
135
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015748 Dorr, J.; Buchholz, C. (1978) Metolachlor + Atrazine (Bicep
4.5L): AG-A No. 4751 I,II. (Unpublished study received Mar 16,
1979 under 100-583; prepared in cooperation with EN-CAS Analyti-
cal Laboratories, submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:237817-K)
00015749 Chamberlain, E.; Stahlberg, L. (1979) Metolachlor + Atrazine (Bi-
cep 4.5L): AG-A No. 4793 A. (Unpublished study received
Mar 16, 1979 under 100-583; prepared in cooperation with EN-CAS
Analytical Laboratories, submitted by Ciba-Geigy Co"p., Greens-
boro, N.C.; CDL:237817-L)
00015750 Rose, W.; Monaco, T. (1978) Metolachlor + Atrazine (Bicep 4.5L):
AG-A No. 4809. (Unpublished study received Mar 16, 1979 under
.100-583; prepared in cooperation with EN-CAS Analytical Labora-
tories, submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
237817-M)
00015751 Rose, W.; Worsham, p.; Slagowski, J.L. (1978) Metolachlor
(Dual 8E); Atrazine (AAtrex SOW); Paraquat (Paraquat
CL): AG-A No. 4959 I,II. (Unpublished study received Mar 16,
1979 under 100-583; prepared in cooperation with EN-CAS Labora-
tories and Chevron Chemical Co., submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:237819-F)
00015752 Kern, C.L.; Staniforth, D.; Slagowski, J.L. (1978) Metolachlor
(Dual 8E); Atrazine (AAtrex SOW or 4L); Paraquat
(Paraquat CL): AG-A No. 5000 1,11. (Unpublished study received
Mar 16, 1979 under 100-583; prepared in cooperation with Iowa
State Univ., EN-CAS Laboratories and Chevron Chemical Co., sub-
mitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:237819-H)
00015753 Schnappinger, M.G. (1979) Metolachlor (Dual 8E); Atrazine
(AAtrex 80W); Glyphosate (Roundup 4E): AG-A No. 4888
1,11. (Unpublished study received Mar 16, 1979 under 100-583;
prepared in cooperation with EN-CAS Laboratories and ADC Labora-
tories, submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
237819-1)
00015754 Rose, W.; Worsham, D. (1979) Metolachlor (Dual 8E); Atrazine
(AAtrex SOW); Glyphosate (Roundup 4E): AG-A No. 4960 I,
II. (Unpublished study received Mar 16, 1979 under 100-583;
prepared in cooperation with EN-CAS Laboratories and ADC Labora-
tories, submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
237819-J)
136
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015755 Searcy, S.; Herman, D. (1979) Metolachlor (Dual 8E); Atrazine
(AAtrex 4L); Glyphosate (Roundup 4E): AG-A No. 4983 I,
II. (Unpublished study received Mar 16, 1979 under 100-583;
prepared in cooperation with EN-CAS Laboratories and ADC Labora-
tories, submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
237819-K)
00015756 Kern, C.L.; Staniforth, D. (1979) Metolachlor (Dual 3E); Atrazine
(AAtrex SOW or 4L); Glyphosate (Roundup 4E): AG-A No. 4999 I,
II. (Unpublished study received Mar 16, 1979 under 100-583;
prepared in cooperation with Iowa State Univ., EN-CAS Labora-
tories and ADC Laboratories, submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:237819-L)
00015757 Dorr, 0.; Buchholz, C. (1979) Metolachlor (Dual 8E); Atrazine
(AAtrex 4L); Glyphosate (Roundup 4E): AG-A No. 5004. (Unpub-
lished study received Mar 16, 1979 under 100-583; prepared in
cooperation with EN-CAS Laboratories and ADC Laboratories, sub-
mitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:237819-M)
00015760 Kincaid, L. (1979) Metolachlor + Glyphosate + Linuron; Dual 8E +
Roundup 4E + Lorox 50W: AG-A No. 4763 I,II. (Unpublished study
including letter dated May 23, 1978 from J.D. Riggleman to Rob-
ert A. Kahrs, received Mar 16, 1979 under 100-583; prepared in
cooperation with E.I. du Pont de Nemours & Co., Inc. and ADC
Laboratories, submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:237821-B)
00015761 Schnappinger, M.G. (1979) Metolachlor + Glyphosate + Linuron; Dual
8E + Roundup 4E + Lorox 50W: AG-A No. 4886 1,11. (Unpublished
study including letter dated May 23, 1978 from J.D. Riggleman to
Robert A. Kahrs, received Mar 16, 1979 under 100-583; prepared
in cooperation with E.I. du Pont de Nemours & Co., Inc. and ADC
Laboratories, submitted by Ciba-Geigy Corp., Greensboro, N.C.:
CDL:237821-C)
00015762 Searcy, V.; Herman, D. (1979) Metolachlor •»• Glyphosate + Linuron;
Dual 8E + Roundup 4E + Lorox 50W: AG-A No. 4893 I,II. (Unpub-
lished study including letter dated May 23, 1978 from J.D. Rig-
gleman to Robert A. Kahrs, received Mar 16, 1979 under 100-583;
prepared in cooperation with E.I. du Pont de Nemours & Co.,
Inc. and ADC Laboratories, submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:237821-D)
137
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MR ID CITATION
00015763 Rose, W.; Worsham, D. (1979) Metolachlor + Glyphosate + Linuron;
Dual 8E + Roundup 4E + Lorox SOW: AG-A No. 4956 I,11 A. (Unpub-
lished study including letter dated May 23, 1978 from J.D. Rig-
gleman to Robert A. Kahrs, received Mar 16, 1979 under 100-583;
prepared in cooperation with Rocky Mount Experiment Station, ADC
Laboratories and E.I. du Pont de Nemours & Co., Inc., submitted
by Ciba-Geigy Corp., Greensboro, N.C.; CDL:237821-E)
00015764 Kincaid, L. (1979) Metolachlor (Dual 8E); Glyphosate (Roundup
4E); Metrlbuzin (Sencor SOW): AG-A No. 4765 I,II. (Unpublished
study including letter dated May 23, 1973 from J.D. Riggleman to
Robert A. Kahrs, received Mar 16, 1979 under 100-533; prepared
in cooperation with ADC Laboratories and E.I. du Pont de Nemours
& Co., Inc., submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:237321-F)
00015765 Schnappinger, M.G. (1978) Metolachlor (Dual 8E); Glyphosate (Round-
. . up 4E); Metribuzin (Sencor SOW): AG-A No. 4887 I,II. (Unpub-
. •'-••".' lished study including letter dated May 23, 1978 from J.D.
Riggleman to Robert Kahrs, received Mar 16, 1979 under 100-583;
prepared in cooperation with ADC Laboratories and E.I. du Pont
de Nemours & Co., Inc., submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:237821-G)
00015766 Searcy, S.; Herman, D. (1979) Metolachlor (Dual 8E); Glyphos-
ate (Roundup 4E); Metribuzin (Sencor SOW): AG-A No. 4895 1,11.
(Unpublished study including letter dated May 23, 1978 from J.D.
Riggleman to Robert A. Kahrs, received Mar 16, 1979 under 100-
533; prepared in cooperation with ADC Laboratories and E.I. du
Pont de Nemours & Co., Inc., submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:237821-H)
00015767 Rose, W.; Worsham, D. (1979) Metolachlor (Dual 8E); Glyphos-
ate (Roundup 4E); Metribuzin (Sencor 50W): AG-A No. 4958 1,11 A.
(Unpublished study including letter dated May 23, 1978 from J.D.
Riggleman to Robert A. Kahrs, received Mar 16, 1979 under 100-
583; prepared in cooperation with ADC Laboratories and E.I. du
Pont de Nemours & Co., Inc., submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:237821-I)
00015768 Kincaid, L.; Slagowski, J.L. (1978) Metolachlor + Linuron + Para-
quat; Dual 8E + Lorox SOW + Paraquat 2CL: AG-A No. 4762 1,11.
(Unpublished study including letter dated May 23, 1978 from J.D.
Riggleman to Robert A. Kahrs, received Mar 16, 1979 under 100-
583; prepared in cooperation with Chevron Chemical Co. and E.I.
du Pont de Nemours & Co., Inc., submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:237821-J)
138
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MR ID CITATION
00015769 Searcy, V.; Herman, D.; Slagowski, J.L. (1978) Metolachlor + Linu-
ron + Paraquat: Dual 8E + Lorox 50W + Paraquat 2CL: AG-A
No. 4892 I,II. (Unpublished study including letter dated
May 23, 1978 from J.D. Riggleman to Robert A. Kahrs, received
Mar 16, 1979 under 100-583; prepared in cooperation with Chevron
Chemical Co. and E.I. du Pont de Nemours & Co., Inc., submitted
by Ciba-Geigy Corp., Greensboro, N.C.; CDL:237821-L)
00015770 Schnappinger, M.G.; Slagowski, J.L. (1978) Metolachlor + Linuron +
Paraquat (Dual 3E + Lorox SOW + Paraquat 2CL): AG-A No. 4915 I,
II. (Unpublished study including letter dated May 23, 1978 from
J.D. Riggleman to Robert A. Kahrs, received Mar 16, 1979 under
100-583; prepared in cooperation with Chevron Chemical Co. and
E.I. du Pont de Nemours & Co., Inc., submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL.-237821-L)
00015771 Rose, W.; Worsham, D.; Slagowski, J.L. (1978) Metolachlor + Linuron
+ Paraquat: Dual 8E + Lorox 50W + Paraquat 2CL: AG-A
No. 4955 I,II. (Unpublished study including letter dated May
23, 1978 from J.D. Riggleman to Robert A. Kahrs, received Mar
16, 1979 under 100-583; prepared in cooperation with Rocky Mount
Experiment Station, Chevron Chemical Co. and E.I. du Pont de
Nemours & Co., Inc., submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:237821-M)
00015772 Kincaid, L.; Slagowski, J.L. (1978) Metolachlor (Dual 8E);
Metribuzin (Sencor 50W); Paraquat (2C1): AG-A No. 4764 I,II.
(Unpublished study including letter dated May 23, 1978 from
J.D. Riggleman to Robert A. Kahrs, received Mar 16, 1979 under
100-583; prepared in cooperation with E.I. du Pont de Nemours &
Co., Inc. and Chevron Chemical Co., submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:237821-M)
00015773 Searcy, S.; Herman, D.; Slagowski, J.L. (1978) Metolachlor
(Dual 8E); Metribuzin (Sencor 50W); Paraquat (2C1): AG-A
No. 4894 1,11. (Unpublished study including letter dated
May 23, 1978 from J.D. Riggleman to Robert A. Kahrs, received
Mar 16, 1979 under 100-583; prepared in cooperation with E.I. du
Pont de Nemours & Co., Inc. and Chevron Chemical Co., submitted
by Ciba-Geigy Corp., Greensboro, N.C.; CDL:237821-0)
00015774 Schnappinger, M.G.; Slagowski, J.L. (1978) Metolachlor (Dual
8E); Metribuzin (Sencor 50W); Paraquat (2 Cl): AG-A No. 4916 I,
II. (Unpublished study including letter dated May 23, 1978 from
J.D. Riggleman to Robert A. Kahrs, received Mar 16, 1979 under
100-583; prepared in cooperation with E.I. du Pont de Nemours &
Co., Inc. and Chevron Chemical Co., submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:237821-P)
139
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015775 Rose, W.; Worsham, D.; Slagowski, J.L. (1978) Metolachlor (Du-
al 8E); Metribuzin (Sencor 50W); Paraquat (Cl): AG-A No.
4957 I,II. (Unpublished study including letter dated May 23,
1978 from J.D. Riggleman to Robert A. Kahrs, received Mar 16,
1979 under 100-583; prepared in cooperation with E.I. du Pont
de Nemours & Co., Inc. and Chevron Chemical Co., submitted by
Ciba-Geigy Corp., Greensboro, N.C.; CDL:237821-Q)
00015777 Stahlberg, L. (1978) Metolachlor (Dual 8E); Naptalam + DNBP (Dya-
nap 3E): AG-A No. 4728 1,11. (Unpublished study received Mar
16, 1979 under 100-533; prepared in cooperation with Biospher-
ics, Inc. for Uniroyal Chemical Co., submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:237822-B)
00015778 Herman, D. (1978) Metolachlor (Dual 8.E); Naptalam + DNBP (Dya-
nap 3E): AG-A No. 4896 1,11. (Unpublished study received
Mar 16, 1979 under 100-583; prepared in cooperation with Bio-
spherics, Inc. for Uniroyal Chemical Co., submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:237822-C)
00015779 Schnappinger, M.G. (1978) Metolachlor (Dual 8E); Naptalam +
DNBP (Dyanap 3E): AG-A No. 4934 I,II. (Unpublished study re-
ceived Mar 16, 1979 under 100-583; prepared in cooperation with
Biospherics, Inc. for Uniroyal Chemical Co., submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:237822-D)
00015780 Dill, R. (1978) Metolachlor (Dual -8E); Naptalam + DNBP (Dyanap 3E):
AG-A No. 5053. (Unpublished study received Mar 16, 1979 under
100-583; prepared in cooperation with Biospherics, Inc. for Uni-
royal Chemical Co., submitted by Ciba-Geigy Corp., Greensboro,-
N.C.; CDL:237822-E)
00015786 Chamberlain, E.; Taylor, T.D. (1978) Metolachlor, Dual 8E;
Dicamba, Banvel: AG-A No. 4865 I, II. (Unpublished study re-
ceived Mar 16, 1979 under 100-583; submitted by Ciba-Geigy
Corp., Greensboro, N.C.; CDL:237818-E)
00015787 Chamberlain, E.; Kern, C.L. (1978) Metolachlor, Dual 8E; Di-
camba, Banvel: AG-A No. 4948 1,11. (Unpublished study received
Mar 16, 1979 under 100-583; submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:237818-F)
00015950 Shriver, J.;. Guthrie, C. (1975) Residue Report: Field Corn: AG-A
No. 3406 II. (Unpublished study received Mar 26, 1975 under
5F1606; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
094379-AB)
140
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00015954 Turner, W.E. (1974) Residue Report: Field Corn: AG-A No. 3057.
(Unpublished study received Sep 26, 1974 under 5G1553; submitted
by Ciba-Geigy Corp., Greensboro, N.C.; CDL:094216-F)
00015955 Luke, J.E.; Slagowski, J.L. (1978) Metolachlor (Dual 8E);
Atrazine (AAtrex SOW); Paraquat (Paraquat CL): AG-A
No. 4964. (Unpublished study received Mar 16, 1979 under 100-
583; prepared in cooperation with EN-CAS Laboratories and Chev-
ron Chemical Co., submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:237819-G)
00016248 Richards, R.F. (1976) Residue Report: Soybeans: AG-A No. 3948.
(Unpublished study received Jan 19, 1977 under 100-583; submit-
ted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:095747-U)
00016296 Kaiser, F.E. (1974) Soil Degradation Study of Gba-Geigy 14C-
CGA-24705. (Unpublished study received Mar 27, 1975 under
5F1606; prepared by Analytical Biochemistry Laboratories, Inc.,
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:094376-N)
00016301 Aziz, S.A. (1974) Photolysis of CGA-24705 on Soil Slides under Nat-
ural and Artificial Sunlight Conditions: Report No. GAAC-74102.
(Unpublished study received on unknown date under 5F1606; sub-
mitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:094385-J)
00016306 Hermes, P. (1972) Biphasic Extraction of Radioactive Metabolites
from Treated Biological Material. Method no. AG-214 dated
Aug 15, 1972. (Unpublished study received Sep 26, 1974 under
5F1606; submitted by Ciba-Geigy Corp., Greensboro, N.C.; COL:
094385-Q)
00016392 Houseworth, L.D.; Roll a, H. (1977) Residues of Metolachlor and
Atrazine in or on Corn Grain Resulting from Tank Mix Applica-
tions with and without Liquid Fertilizer—Preplant Incorporated
and Preemergence Applications: Report No. ABR-77017. (Unpub-
lished study received Feb 18, 1977 under 100-583; submitted by
Ciba-Geigy Corp., Greensboro, N.C.; CDL:228126-A)
00016393 Seim, V. (1976) Residue Report: Field Corn: AG-A No. 3672 II-III.
(Unpublished study received Feb 18, 1977 under 100-583; sub-
mitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:228126-D)
00016394 Seim, V. (1976) Residue Report: Field Corn: AG-A No. 3673 1,11,111.
(Unpublished study received Feb 18, 1977 under 100-583; sub-
mitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:228126-E)
141
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00016395 Ragsdale, D.; Stahlberg, L. (1976) Residue Report: Field Corn:
AG-A No. 3704 1,11. (Unpublished study received Feb 18, 1977
under 100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:228126-F)
00016396 Taylor, T.D.; Shriver, J.; Wendling, C. (1976) Residue Report:
Field Corn: AG-A No. 3734 1,11,111. (Unpublished study received
Feb 18, 1977 under 100-583; submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:228126-G)
00016397 Shriver, J.; Wendling, C. (1976) Residue Report: Field Corn:
AG-A No. 3735 1,11,111. (Unpublished study received Feb 18,
1977 under 100-583; submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:228126-H)
00016398 Snow, J.G.; Tinklepaugh, ? (1976) Residue Report: Field Corn: AG-A
No. 3799 11,111. (Unpublished study received Feb 18, 1977 under
.- - 100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
: 228126-1)
00016399 Thetford, L.; Snow, J.G.; Tinklepaugh, ? (1976) Residue Report:
Sweet Corn: AG-A No. 3858. (Unpublished study received Feb 18,
1977 under 100-583; submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:228126-J)
00016425 Fink, R. (1974) Final Report: Eight-Day Dietary LC50—Mallard
Ducks: Project No. 108-111. (Unpublished study received on un-
known date under 5G1553; prepared by Truslow Farms, Inc. in co-
operation with Maryland, Dept. of Agriculture, Div. of Inspec-
tion and Regulation, submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:094220-0)
00016426 Fink, R. (1974) Final Report: Eight-Day Dietary LC50—Bobwhite
Quail: Project No. 108-110. (Unpublished study received on un-
known date under 5G1553; prepared by Truslow Farms, Inc. in co-
operation with Maryland, Dept. of Agriculture, Div. of Inspec-
tion and Regulation, submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:094220-P)
00016427 Kahrs, R.A. (1979) Residues of Metolachlor and Chloramben in Soy-
beans Resulting from Preemergence or Preplant Incorporated Ap-
plications: Report No. ABR-79068. Summary of studies 238677-B
through 238677-D. (Unpublished study received Jun 20, 1979 un-
der 100-583j submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:238677-A)
142
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00016435 Houseworth, L.D. (1977) Residues of Metolachlor and Dicamba in or
on Corn Grain Resulting from Preemergence Tank Mix Applications:
Report No. ABR-77071. Summary of studies 232192-B through
232192-D. (Unpublished study received Nov 10, 1977 under 100-
EX-59; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
.; 232192-A)
00016436 Chamberlain, E.; Coan, R.M. (1977) Residue Report: Field Corn: AG-A
No. 4253 II. (Unpublished study received Nov 10, 1977 under
100-EX-59; prepared in cooperation with Velsicol Chemical Corp.,
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:232192-B)
00016437 Chamberlain, E.; Kern, C.L. (1977) Residue Report: Field Corn: AG-A
No. 4264 II. (Unpublished study received Nov 10, 1977 under
100-EX-59; prepared in cooperation with Velsicol Chemical Corp.
and Craven Laboratories, submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:232192-C)
00016438.Chamberlain, E.; Taylor, T.D. (1977) Residue Report: Field Corn:
AG-A No. 4270 III. (Unpublished study received Nov 10, 1977 un-
der 100-EX-59; prepared in cooperation with Velsicol Chemical
Corp. and Craven Laboratories, submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:232192-D)
00016440 Kahrs, R.A. (1977) Tank Mixes of Metolachlor plus Atrazine plus
Paraquat—Corn: No and Minimum Tillage Applications: Report
No. ABR-77074. Summary of studies 232192-1 through 232192-M.
(Unpublished study received Nov 10, 1977 under 100-EX-59; sub-
mitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:232192-H)
00016441 Thomas, J.; Herman, D.; Slagowski, J.L. (1977) Residue Report:
Field Corn: AG-A No. 4167 II. (Unpublished study received Nov
10, 1977 under 100-EX-59; prepared in cooperation with Chevron
Chemical Co., submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:232192-I)
00016442 Coan, R.M.; Karusta, G.; Slagowski, J.L. (1977) Residue Report:
Field Corn: AG-A No. 4187 II,111. (Unpublished study received
Nov 10, 1977 under 100-EX-59; prepared in cooperation with
Chevron Chemical Co., submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:232192-J)
00016443 Schnappinger, M.G.; Slagowski, J.L. (1977) Residue Report: Field
Corn: AG-A No. 4198 11,111. (Unpublished study received Nov 10,
1977 under 100-EX-59; prepared in cooperation with Chevron Chem-
ical Co., submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
232192-K)
143
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MR ID CITATION
00016444 Westmoreland, W.G.; Slagowski, J.L. (1977) Residue Report: Field
Corn: AG-A No. 4247 II,111. (Unpublished study received Nov 10,
1977 under 100-EX-59; prepared in cooperation with Chevron Chem-
ical Co., submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
232192-L)
00016445 Davidson, W.E.; Slagowski, J.L. (1977) Residue Report: Field Corn:
AG-A No. 4288 1,11. (Unpublished study received Nov 10, 1977
under 100-EX-59; prepared in cooperation with Chevron Chemical
Co., submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
232192-M)
00016596 Kahrs, R.A. (1978) Residues in Field Corn Grain Resulting from the
Application of Dual 8E Alone and in Tank Mixture with Atra-
zine: Report No. ABR-78022. Summary of studies 232949-B through
232949-F. (Unpublished study received Mar 1, 1978 under 100-
597; submitted by Ciba-Geigy Corp., Greensboro, N.C.; COL:
232949-A)
00016598" Turner, W.E. (1978) Metolachlor (Dual 8E): AG-A No. 4860 II.
(Unpublished study received Mar 1, 1978 under 100-597; submitted
by Ciba-Geigy Corp., Greensboro, N.C.; CDL:232949-C)
00016604 Shriver, J.; Wendling, C. (1976) Residue Report: Soybeans: AG-A
No. 3724. (Unpublished study received May 11, 1978 under
100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
097135-C)
00016507 Cheung, M.W.; Kahrs, R.A. (1979) Residues in Sorghum Resulting from
Applications of Milocep 5L—Preplant Incorporated and Preemer-
gence Applications: Report No. ABR-79015. Summary of studies
237815-B through 237815-F. (Unpublished study received Mar 16,
1979 under 100-604; submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:237815-A)
00016608 Davidson, W.E. (1979) Metolachlor-Propazine (Milocep 5L): AG-A
No. 5159 I-11 A. (Unpublished study received Mar 16, 1979 under
100-604; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
237815-B)
00016609 Dill, R. (1978) Metolachlor + Propazine (Milocep 5L): AG-A
No. 5176 A. (Unpublished study received Mar 16, 1979 under 100-
604; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
237815-C)
144
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00016610 Dill, R. (1978) Metolachlor-Propazine (Milocep 5L): AG-A
No. 5176 II. (Unpublished study received Mar 16, 1979 under
100-604; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
237815-D)
00016632 Jessup, D.C.; Estes, F.L.; Jefferson, N.D.; et al. (1979) 6-Month
Chronic Oral Toxicity Study in Beagle Dogs: IRDC No. 332-054.
(Unpublished study including Addendum and AG-A No. 5358, re-
ceived Dec 11, 1979 under 100-597, prepared by International
Research and Development Corp., submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:099116-C)
00016990 Davidson, W.E. (1978) Metolachlor + Propazine; Dual 8E + Milo-
gard 4L: Grain Sorghum: AG-A No. 4883 II A. (Unpublished
study received Nov 24, 1978 under 100-EX-62; submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:235981-B)
00016991 Chamberlain, E.; Threewitt, T. (1978) Metolachlor + Propazine;
-- - _ Dual 8E + Milogard SOW: Grain Sorghum: AG-A No. 4926
II B. (Unpublished study received Nov 24, 1978 under 100-EX-62;
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:235981-C)
00016992 Turner, W.E. (1978) Metolachlor + Propazine; Dual 3E + Milo-
gard SOW: Grain Sorghum: AG-A No. 4995 A. (Unpublished
study received Nov 24, 1978 under 100-EX-62; submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:235981-D)
00017690 Coquet, B.; Galland, L.; Guyot, D.; et al. (1974) Essai de Toxicite
de 3 Mois chez le Chi en par Voie Orale du Produit CGA 24 705.
Three-Month Oral Toxicity Test of CGA 24 705 in Dog: IC-DREB-R
740119. (Unpublished study including translation, received Sep
26, 1974 under 5G1553; prepared by Oncins Research and Breeding
Center, submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
112842-A)
00017699 Schnappinger, H.G. (1979) Simazine (Princep 4L); Metolachlor
(Dual (R) 8E); Paraquat (Paraquart 2CL); Glyphosate (Roundup
4E): AG-A No. 5242 I-IIA- (Unpublished study received Jan 4,
1980 under 100-583; prepared in cooperation with En-Cas Labora-
tories, Chevron Chemical Co. and Analytical Development Corp.;
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:241543-B)
00017700 Rose, W.; Worsham, D. (1979) Simazine (Princep 4L); Metola-
chlor (Dual 8E); Paraquat (Paraquat 2CL); Glyphosate
Roundup 4E): AG-A No. 5354. (Unpublished study received Jan 4,
1980 under 100-583; submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:241543-D)
145
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00013722 Buccafusco, R.J.; Stiefel, C.; Sullivan, D.M.; et al. (1978) Acute
Toxicity of CGA-24705 to Rainbow Trout (Salmo gairdneri):
Report #BW-78-6-186. (Unpublished study received Jul 13, 1978
under 100-597; prepared by EG&G, Bionomics, submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:234396-B)
00018723 Buccafusco, R.J.; Stiefel, C.; Sullivan, D.M. (1978) Acute Toxicity
of CGA-24705 to Bluegill (Lepomis macrochirus): Report #BW-
78-6-181. (Unpublished study received Jul 13, 1978 under 100-
597; prepared by EG&G, Bionomics, submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:234396-C)
00022872 Sumner, D.D.; Cassidy, J.E. (1975) The Uptake and Distribution of
Phenyl-14C-CGA-24705 from Soil in Greenhouse Grown Soybeans:
Report No. GAAC 75039. (Unpublished study received Jan 19, 1977
under 100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:095750-F)
.0002.2373 Sumner, D.; Cassidy, J. (1974) The Uptake and Distribution of Phen-
yl-14C-CGA-24705 from Soil in Greenhouse Grown Corn: Report
No. GAAC-74015. (Unpublished study received Sep 26, 1974 under
5F1606; submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
094385-B)
00022374 Sumner, D.; Cassidy, J. (1974) The Uptake and Distribution of Phen-
yl-14C-CGA-24705 in Field Grown Corn: Report No. GAAC-74022.
(Unpublished study received Sep 26, 1974 under 5F1606; submitted
by Ciba-Geigy Corp., Greensboro, N.C.; CDL:093485-C)
00022878 Sumner, D.D.; Cassidy, J.E. (1974) The Uptake of Phenyl-14C-CGA-
24705 and Its Aged Soil Degradation Products in Rotation Wheat:
Report No. GAAC-74071. (Unpublished study received Sep 26, 1974
under 5F1606; submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:094385-H)
00022879 Szolics, I.M.; Cassidy, J.E. (1978) The Uptake and Balance of Phen-
yl-14C-Metolachlor in Field Rotation Lettuce Planted in the
Fall: Report No. ABR-78085. (Unpublished study received Aug 1,
1979 under 100-583; submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:238899-C)
00022880 Szolics, I.M.; Cassidy, J.E. (1978) The Uptake and Balance of Phen-
yl 14C-Metolachlor in Field Rotation Lettuce Planted in the
Spring: Report No. ABR-78086. (Unpublished study received Aug
1, 1979 under 100-583; submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:238899-D)
146
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OFFICE. OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00022881 Sumner, D.D.; Cassidy, J.E. (1974) The Uptake of Phenyl-14C-CGA-
24705 and Its Aged Soil Degradation Products in Rotation Soy-
beans: Report No. GAAC-74113. (Unpublished study received Jun
30, 1978 under 100-583; submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:234216-G)
00022882 Sumner, D.D.; Cassidy, J.E, (1974) The Uptake of Phenyl-14C-CGA-
24705 and Its Aged Soil Degradation Products in Rotation Car-
rots: Report No. GAAC-74112. (Unpublished study received Jun
30, 1978 under 100-583; submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:234216-H)
00022883 Sumner, D.D.; Cassidy, J.E. (1974) The Uptake of Phenyl-14C-CGA-
24705 and Its Aged Soil Degradation Products in Rotation Oats:
Report No. GAAC-74085. (Unpublished study received Jun 30, 1978
under 100-583; submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:234216-I)
00022885 Roger, J.C.; Cassidy, J.E. (1974) Metabolism and Balance Study of
Phenyl-14C-CGA-24705 in a Lactating Goat: Report No. GAAC-
74020. (Unpublished study received Sep 26, 1974 under 5G1553;
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:094217-G)
00022386 Goldhamer, R.E. (1973) Final Report: Metabolism of delta 14C-
CGA--24705 Corn Biosynthesized Metabolites in a Lactating Goat.
(Unpublished study received Sep 26, 1974 under 5G1553; prepared
by Biometric Testing, Inc., submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:094217-I)
00022887 Roger, J.C.; Cassidy, J.E. (1974) Metabolism and Balance Study of
Phenyl-14C-CGA-24705 Corn Biosynthesized Metabolites in a
Goat: Report No. GAAC-74046. (Unpublished study received Sep
26, 1974 under 5G1553; submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL:094217-L)
00039174 Seim, V.; Peek, J.; Stahlberg, L.; et al. (1975) Residue Report:
Soybeans: AG-A No. 3268 1,11,III. (Unpublished study including
AG-A nos. 3466 I,II, 3523 1,11,111, 3570 I,II,III..., received
Nov 25, 1975 under 6G1708; submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:094878-A)
00039176 Ciba-Geigy, Limited (19??) CGA 24 705 Feeding Study in Milk Cows:
Methods. (Unpublished study received Nov 25, 1975 under 6G1708;
submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:094878-D)
147
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MR3D CITATION
00039181 Schenker, M.; Wartenweller, B. (1975) CGA 24705: Determination of
the Degradation Product CGA 49751 in Chicken Liver: Switzerland
1973: No. RVA 02/75. (Unpublished study received Nov 25, 1975
under 6G1708; prepared by Ciba-Geigy, Ltd., submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:094878-J)
00039192 Hambock, H. (1974) Distribution, Degradation and Excretion of CGA
24 705 in the Rat: Project Report No. 1/74. (Unpublished study
received Nov 25, 1975 under 6G1708; prepared by Ciba-Geigy,
Ltd., submitted by Ciba-Geigy Corp., Greensboro, N.C.; CDL:
094984-N)
00039193 Hambock, H. (1974) Metabolism of CGA 24 705 in the Rat: Project
Report No. 7/74. (Unpublished study received Nov 25, 1975 un-
der 6G1708; prepared by Ciba-Geigy, Ltd., submitted by Ciba-
Geigy Corp., Greensboro, N.C.; CDL:094984-0)
00039194 Tisdel, M.; Balk, M.W.; .Jackson, T.; et al. (1980) Toxicity Study:
.... . Metolachlor on Mice. (Unpublished study including study no.
. •'•:• 79020, received Jul 25, 1980 under 100-587; prepared by Raltech
Scientific Services, Inc. and American College of Laboratory
Animal Medicine, submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:24294l-A)
00041283 Lightkep, G.E.; Christian, M.S.; Christian, G.D.; et al. (1980)
Teratogenic Potential of CGA-24705 in New Zealand White Rabbits:
Segment II Evaluation—Project 203-001. (Unpublished study re-
ceived Sep 15, 1980 under 100-597; prepared by Argus Research
Laboratories, Inc., submitted by Ciba-Geigy Corp., Greensboro,
N.C.; CDL:099630-A)
00062465 Fink, R.; Beavers, J.B.; Brown, R.; et al. (1981) Final Report:
Acute Oral LD50—Mallard Duck: Project No. 108-200. (Unpub-
lished study received Mar 31, 1981 under 100-587; prepared by
Wildlife International, Ltd. and Washington College, submitted
by Ciba-Geigy Corp., Greensboro, N.C.; CDL:244691-B)
00063398 Tisdel, M. (1981) Two-Year Chronic Oral Toxicity and Oncogenlcity
Study with Metolachlor Technical in Albino Rats: Raltech Study
No. 80030. (Unpublished study received Jan 28, 1981 under 100-
587; prepared by Ralston Purina Co., submitted by Clba-Gelgy
Corp., Greensboro, N.C.; CDL:244l66-A)
148
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00064182 Ciba-Geigy Corporation (1980) Residue of Dual 8E and Eptam 6E
on Kidney Beans and Various Other Beans. (Compilation; unpub-
lished study received Mar 31, 1981 under 100-597; CDL:099988-B)
00065047 Kahrs, R.A. (1981) Residues of Metolachlor In Cottonseed Resulting
from Applications Alone or in Tank Mixture with Prometryn or
Fluometuron: Report No. ABR-81012. (Unpublished study received
Apr 28, 1981 under 100-597; submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:070049-A)
00065048 Ciba-Geigy Corporation (1981) Residue Tests with Cotton. (Com-
pilation; unpublished study received Apr 28, 1931 under 100-597;
CDL:070049-B)
00074398 Szolics, I.M.; Simoneaux, B.J.; Cassidy, J.E. (1981) The Uptake and
Distribution of Pheny1-14C-metolachlor from Soil in Green-
house Grown Potatoes: ABR-81023. (Unpublished study received
Jul 15, 1981 under 100-597; submitted by Ciba-Geigy Corp.,
Greensboroi N.C.; CDL:070182-B)
00074900 Szolics, I.M.; Simoneaux, B.J.; Cassidy, J.E. (1981) The Uptake and
Distribution of Phenyl-14C-metolachlo" from Soil in Green-
house Grown Lettuce: ABR-81021. (Unpublished study received Jul
15, 1981 under 100-597; submitted by Ciba-Geigy Corp., Greens-
boro, N.C.; CDL.-070182-D)
00078291 Burkhard, N. (1978) Adsorption and Desorption of Metolachlor
(Dual) in Various Soil Types: Project Report 45/78. (Un-
published study received Jul 23, 1981 under 100-587; prepared by
Ciba-Geigy, Ltd., Switzerland, submitted by Ciba-Geigy Corp.,
Greensboro, N.C.; CDL:245627-D)
00078297 Ciba-Geigy Corporation (1981) Tests for Residues in Various Crops
and Soil. (Compilation; unpublished study received Jul 23,
1981 under 100-587; CDL:245628-A)
00078942 Mobay Chemical Corporation (1981) Addition to Synopsis of Sencor
Residue Chemistry on Various Crops: Addition No. 6. (Compila-
tion; unpublished study received Jul 13, 1981 under 3125-314;
CDL:245572-A)
149
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
00080897 Smith, S.H.; O'Loughlin, C.K.; Salamon, C.M.; et al. (1981) Two-
generation Reproduction Study in Albino Rats with Metolachlor
Technical: Study No. 450-0272. Final rept. (Unpublished
study received Sep 30, 1981 under 100-597; prepared by Whit-
taker Corp., submitted by Ciba-Geigy Corp., Greensboro, N.C.;
CDL:245959-A; 245960; 245961)
00084003 Marias, A.J.; Gesme, J.; Albanese, E.; et al. (1977) Revised Final
Report to Ciba-Geigy Corporation: Carcinogenicity Study with
CGA-24705 Technical in Albino Mice: IBT No. 622-07925 (8532-
07925). (Unpublished study received Jul 7, 1978 under 100-583;
prepared by Industrial Bio-Test Laboratories, Inc;, submitted
by Ciba-Geigy Corp., Greensboro, N.C.; CDL:097169-A; 097170)
00084006 Ciba-Geigy Corporation (1981) Residues of Metolachlor in Safflower
Seed Resulting from Preplant Incorporated or Preemergence Appli-
cations: Report No. ABR-81-47. (Compilation; unpublished study
".." ' '..-•"•=••:- received Nov 12, 1981 under 100-597; CDL:070458-A)
00105956 Ciba-Geigy Corp. (1981) Metolachlor Residues in Corn Resulting
from Preemergence and Preplant Incorporated Applications of
Dual 8E at a Maximum Use Rate of 4.0 Lbs. AI/A. (Compilation;
unpublished study received Jun 25, 1982 under 100-597; CDL:
247755-A)
00105957 Ciba-Geigy Corp. (1982) Residues in or on Potato Tubers Resulting
from 4.0 Lbs. AI/A Preemergence Applications of Dual 8E or Se-
quential Applications of Dual 8E + Sencor/Lexone Tank Mix Pre-
anergence Followed by Dual 8E at Layby. (Compilation; unpub-
lished study received Jun 25, 1982 under 100-597; CDL:247756-A)
00106041 Ciba-Geigy Corp. (1982) Metolachlor—Peanuts: Layby Applications:
Split Applications (Including at Cracking Mixtures with Nap-
talam/Dinoseb) at Cracking Applications with Dinoseb. (Compi-
lation; unpublished study received Jul 7, 1982 under 100-597;
CDL:070977-A)
00106191 Houseworth, L. (1979) Residues of Metolachlor and Metribuzin in
Potato Tubers Resulting from the Use of Metolachlor and Meto- .
lachlor/Metribuzin Tank Mixes for Weed Control in Potato Cul-
ture: Report No.: ABR-79040. (Unpublished study received Apr
25, 1979 under 100-583; submitted by Ciba-Geigy Corp., Greens-
boro, NC; CDL:098227-A)
150
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Metolachlor Standard
MRID CITATION
GS0001-001 Fink, R.; Beavers, J.; Grimes, J. et al. (1978) One-Generation
Reproduction Study—Bobwhite Quail: CGA-24705 Technical Metol-
achlor Final Report: Project No. 108-150. Unpublished study ;
prepared by Wildlife International Ltd. 24 p.
GS0001-002 Fink, R.; Beavers, J.; Grimes, J. et al. (1978) One-Generation
Reproduction Study—Mallard Duck, Metolachlor Technical
(CGA-24705): Final Report: Project No. 108-152. Unpublished
study prepared by Wildlife International Ltd. 26 p.
GS0001-003 Dionne, E. (1978) Chronic Toxicity of CGA-24705 to the Fathead
Minnow (Pimephales promelas): Report #BW-78-l1-341. Unpublished
study prepared by EG & G, Bionomics. 46 p.
151
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APPENDIX V
FORMS APPENDICES
152
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FIFRA SECTION 3(C)(2HS) SUMMARY SHEET
EPA REGISTRATION NO.
PRODUCT NAME
.NT'S NAME
DATE GUIDANCE DOCUMENT ISSUED
With respect to the requirement to submit "generic" data imposed by the FIFRA action 3(C)(2)(B) notice contained in the referenced
Guidance Document, I am responding in the following manner
O 1. I will submit data in a timely manner to satisfy the following requirements. If the test procedures I will use deviate from (or are not
specified in) the Registration Guidelines or the Protocols contained in the Reports of Expert Groups to the Chemicals Group, OECD
Chemicals Testing Programme, I enclose the protocols that I will use:
Q 2. I have entered into an agreement with one or more other registrants under FIFRA section 3(C)(2)(B)(ii) to satisfy the following data
requirements. The tests, and eny required protocols, will be submitted to EPA by:
NAME OF OTHHR REGISTRANT
D 3. I enclose a completed "Certification of Attempt to Enter Into an Agreement with Other Registrants for Development of Data" with
— respen to the following data requirements:
G 4. I request that you amend my registration by deleting the following uses (this option is not available to applicants for new products):
O 5. I request voluntary cancellation of the registration of this product (This option is not available to applicants for new products)
REGISTRANTS AUTHORIZED REPRESENTATIVE
SIGNATURE
DATE
EPA Form 85EO-1 (10-82)
153
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OMB Approval No. 2000-0458 .
(To Qualify, certify ALL four hems)
CcnTJrJCATJCN OF A775.VP77C SNT2R
INTO AN AGREEMENT WITH OTHER REGISTRANTS
FOR DEVELOPMENT OF DATA
1. I tm duly authorized to represent the following firm(s) who are subject to the require-
ments of a Notice under FIFRA Section 3(c)(2)(B) contained in a Guidance Document
to submit data concerning the active ingredient:
NAME OP FIRM
GUIDANCE DOCUMENT DATE
ACTIVE INGREDIENT
EPA COMPANY NUMBER
(This firm or group of firms is referred to below as "my firm".)
2. My firm is willing to develoe-ancLsubmit the data as required by that Notice, if necessary. However, my firm would prefer to eKer
into an agreement with one or more other registrants to develop jointly, or to share in the cost of developing, the following required
items or data:
3. My firm has offered in writing to enter into such an agreement Copies of the offers are attached. That offer was irrevocable and included an offer tr
bound by an arbitration decision under FIFRA Ssction-3(c)(2)(B)(iii) if final agreement on all terms could not be reached otherwise. This offer was<• :.
to the following firmU) on the following date(s): .
NAME OF FIRM
DATE OF OFFER
However, none of those firm(s) accepted my offer.
4. My firm requests that EPA not suspend the registration(s) of my firm's product(s), if any of the firms named in paragraph (3) rt:>vt
have agreed to submit the data listed in paragraph (2) above in accordance with the Notice. I understand EPA will promptly ir,fc.in<
me whether my firm must submit data to avoid suspension of its registration(s) under FIFRA Section 3(c)(2)(8). (This
does not apply to applicants for new products.) I give EPA permission to disclose this statement upon request.
TYPED NAME
SIGNATURE
DATE
-------
EPA Reg. No.
PRODUCT SPECIFIC DATA REPORT
Date
Guidance Document for
Registration
Guideline No.
§158.120
PRODUCT
CHEMISTRY
61-1
61-2
61-3
62-1
. ,.62^2 -••:
62-3
63-2
63-3
63-4
63-5
63-6
63-7
: 63-8
63-9
63-10
63-H
63-12
Name of Test
-=-.* —
Identity of
ingredients
Statement of
composition
Discussion of
formation of
ingredients
Preliminary
analysis
Certification of
limits
Analytical methods
for enforcement
limits
Color
Physical state
Odor
Melting point
Boillngjpoint
Density, bulk-
density, or
specific gravity
Solubility
Vapor pressure
Dissociation
constant
Octanol/water
partition
coefficient
PH
Test not
required
for my
product
listed
above
(check
below)
I am complying with
data requirements by
Citing MRID
Number or
EPA Accession
Number
Submit-
ting
Data
(At-
tached)
(For EPA Use Only)
Accession Numbers
Assigned
155
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Registration
Guideline No.
63-13
63-14
63-15
63-16
63-17
63-18
63-19
63-20
63-21
§158.135
TOXICOLOGY
; 81-1
81-2
81-3
81-4
81-5
81-6
Name of Test
Stability
Oxidizing/reducing
reaction
Flamnability
Explodabllity
Storage stability
Viscosity
Mlsclblllty
Corrosion
characteristics
Dielectric break-
down voltage
Acute oral
toxicity, rat
Acute dermal
toxicity, rabbit
Acute Inhalation,
toxicityj rat
Primary eye
irritation, rabbit
Primary dermal
Irritation
Dermal sensitlza-
tion
Test not
required
for my
product
listed
above
(check
below)
'
I am complying with
data requirements by
Citing MRID
Number or
EPA Accession
Number
Submit-
ting
Data
(At-
tached)
-^*
(For EPA Use Only)
Accession Numbers
Assigned
-
.
^
156
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