oEPA
Unit«d SUtN
Environmental Protection
Agwicy
Offkwof
Pwtieidw and Toxic SubttaneM
Washington DC 20460
January 1987
PanicidM
Guidance for the
Reregistration of
Pesticide Products
Containing PCNB
as the Active Ingredient
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GUIDANCE FOR THE
REREGISTRATION OF PESTICIDE PRODUCTS
CONTAINING
PENTACHLORONITROBENZENE (PCNB)
AS THE ACTIVE INGREDIENT
CHEMICAL CODE: (056502)
CAS NUMBER: 82-68-8
CASE NUMBER: 0128
JANUARY, 1987
ENVIRONMENTAL PROTECTION AGENCY
OFF-ICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20460
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TABLE OF CONTENTS
'I. Introduction 1
II. Chemical(s) Covered by this Standard 4
A. Description of Chemical
B. Use Profile
C. History of the Chemical
III. Agency Assessment 8
A. Summary
B. Preliminary Risk Assessment
C. Other Science Findings
D. Tolerance Reassessment
IV. Regulatory Position and Rationale 39
A. Regulatory Positions
R.' Criteria for Registration
C. Acceptable Ranges and Limits
D. Required Labeling
V. Products Subject to this Standard 47
VI. Requirement for Submission of Generic Data .... 49
A. What are generic data?
B. Who must submit generic data?
C. What generic data must be submitted?
D. How to comply with DCI requirements
K. Procedures for requesting a change in protocol
F. Procedures for requesting extensions of time
G. Existing stocks provisions upon suspension or
cancellation
VII. Requirement for Submission of Product-Specific Data 54
VIII. Requirement for Submission of Revised Labeling ... 55
IX. Instructions for Submission 56
A. Manufacturing use products (sole active)
B. Manufacturing use products (multiple active)
C. End use products
D. Intras.tate products
E. Addresses
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APPENDICES
Page
I. DATA APPENDICES
Guide to Tables 59
Table A 61
Table B 93
II. LABELING APPENDICES 96
Summary of label requirements and table 96
40 CFR 162.10 Labeling Requirements 104
Physical/Chemical Hazards Labeling Statements 113
Storage Instructions 114
Pesticide Disposal Instructions 115
Container Disposal Instructions 123
III. USE INDEX APPENDIX 124
IV. BIBLIOGRAPHY APPENDICES 168
Guide to Bibliography 169
Bibliography 171
V. FORMS APPENDICES 184
EPA Form 8580-1 FIFRA $3(c)(2)(B) Summary Sheet 185
EPA Form 8580-6 Certification of Attempt to 186
Enter 186 Into an Agreement
with Other Registrants for
Development of Data
EPA Form 8580-4 Product Specific Data Report 187
EPA Form 8570-27 Formulator's Exemption Statement 189
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GLOSSARY/ACRONYMS
1. The Agency: U.S. Environmental Protection Agency/EPA
2. A.I.: Active pesticide ingredient
3. DCl': Data Call-in Notice
4. EPs: End-Use pesticide products
5. EUP: Experimental Use Permit
6. FDA: U.S. Food & Drug Administration
7- FIFRA: Federal Insecticide, Fungicide, Rodenticide Act
(As amended)
8. 40 CFR: Title 40, Code of Federal Regulations
9. Interim tolerance: A temporary tolerance which is established until
such time as a registrant fulfills all of the residue data
requirements for his/her pesticide product(s).
10. MPs: Manufacturing-Use pesticide products
11. NPDES Permit: National Pollutant Discharge Elimination System
permit
12. OES: Office of Endangered Species, U.S. Dept. of the Interior
13. PADI: Interim acceptable daily intake of a chemical in mg/kg/day
by a 60 kg person.
14. RAC's: Raw agricultural commodities
111
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I. INTRODUCTION
EPA has established the Registration Standards program
in order to provide an orderly mechanism by which pesticide
products containing the same active ingredient can be reviewed
and standards set for compliance with FIFRA. The standards
are applicable to reregistration and future applications for
registration of products containing the same active ingredient.
Each registrant of a product containing an active ingredient
subject to this Standard who wishes to continue to sell or
distribute that product must bring his product and labeling
into compliance with FIFRA, as instructed by this Standard.
Pesticides have been grouped into use clusters and will be
reviewed on the basis of a ranking scheme giving higher
priority to (1) pesticides in clusters used on food and feed
crops; and (2) pesticides produced in large volumes.
The Registration Standards program involves a thorough
review of the scientific data base underlying a pesticide's
registration. The purpose of the Agency's review is to
reassess the potential hazards arising from the currently
registered uses of the pesticide; to determine the need for
additional data on health and environmental effects; and to
determine whether the pesticide meets the "no unreasonable
adverse effects" criteria of FIFRA. In its review EPA identifies:
1. Studies that are acceptable to support the data
requirements for the currently registered uses of the
pesticide.
2. Additional studies necessary to support continued
registration. The additional studies may not have been
required when the product was initially registered or may be
nee'ded to replace studies that are now considered inadequate.
3,. Labeling revisions needed to ensure that the product
is not misbranded and that the labeling is adequate to protect
man and the environment.
The detailed scientific review, which is not contained
in this document, but is available upon request^, focuses on
the pesticide active ingredient. The scientific review
•'•The scientific reviews may be requested from the Information
Services Section, Program Management and Support Division
(TS-757C), EPA, Room 236, Crystal Mall #2, 1921 Jefferson Davis
Highway, Arlington, Virginia, 22202 (Telephone (703) 557-4453).
In addition, reviews may be purchased from the National Technical
Information Services, 5285 Port Rdyal Road, Springfield, Virginia
22161, approximately 90 days after issuance of a Standard.
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primarily discusses the Agency's evaluation of and conclusions
from available data in its files pertaining to the pesticide
active ingredient. However, during the review of these data
the Agency is also looking for potential hazards that may be
associated with the end use products that contain the active
ingredient. The Agency will apply the provisions of this
Registration Standard to end use products if necessary to
protect man and the environment.
EPA's reassessment results in the development of a regulatory
position, contained in this Registration Standard, on the
pesticide and each of its registered uses. See Section IV -
Regulatory Position and Rationale. Based on its regulatory
position, the Agency may prescribe a variety of steps to be
taken by registrants to maintain their registrations in
compliance with FIFRA. These steps may include:
1. Submission of data in support of product registration;
2. Modification of product labels;
3. Modifications to the manufacturing process of the
pesticide to reduce the levels of impurities or contaminants;
4. Restriction of the use of the pesticide to certified
applicators or other specially trained individuals;
5. Modification of uses or formulation types; or
6. Specification of packaging limitations.
Failure to comply with these requirements may result in
the issuance of a Notice of Intent to Cancel or a Notice of
Intent to Suspend (in the case of failure to submit data).
In addition, in cases in which hazards to man or the environment
are identified, the Agency may initiate a special review of
the pesticide in accordance with 40 CFR Part 154 to examine
in depth the risks and benefits of use of the pesticide. If
the Agency determines that the risks of the pesticide's use
outweigh the benefits of use, the Agency may propose additional
regulatory actions, such as cancellation of uses of the
pesticide which have been determined to cause unreasonable
adverse effects on the environment.
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EPA has authority under the Data Call-in (DCI) provisions
of FIFRA sec. 3(c)(2)(B) to require that registrants submit
data to answer our questions regarding the chemical, toxicological
and environmental characteristics and fate of a pesticide.
This Registration Standard lists the data EPA believes are
necessary to resolve our concerns about this pesticide.
These data are listed in the Tables A, B, and C in Appendix I.
Failure to comply with the DCI requirements enumerated in
this Registration Standard may result in issuance by EPA of a
Notice of Intent to Suspend the affected product registrations.
Registrants are reminded that FIFRA sec. 6(a)(2) requires
them to submit factual information concerning possible unreason-
able adverse effects of a pesticide at any time that they
become aware of such information. Registrants should notify
the Agency of any information, including interim or preliminary
results of studies, if those results suggest possible adverse
effects on man or the environment. This requirement continues
as long as the products are registered by the Agency.
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II. CHEMICAL COVERED BY THIS STANDARD
Description of chemical
The following chemical is covered by this Registration
Standard:
Common name: PCNB
Chemical name: Pentachloronitrobenzene
CAS Number: 82-68-8
OPP (Shaughnessy) Number: 056502
Empirical Formula:
Trade names;
Cl
Avicol®, Botrilex®, Brassicol®, Earthcide®,
Folosan®, HOE O 26014, Kobu®, Kobutol®, Pentagen®,
Sanidor 30, Terraclor®, Tilcarex®, Tri-PCNB, and
Tritisan®.
Year of Initial
Registration: 1964
Registrants of Aceto Chemical Co, Amvac Chemical
Technical Products: Corp., Uniroyal Chemical, Monsanto
Chemical Co, Quimica Organica de
Mexico.
Description of physical characteristics of chemical:
PCNB is a pale yellow to cream crystalline solid at room
temperature, its melting point is 141-145° C, boiling point
is 328° C, and its molecular weight is 295.3. Its water
solubility is 0.44 mg/liter at 20° C.
Figure 1 presents the chemical structures of PCNB impurities
and various PCNB metabolites.
B. Use Profile
Type of Pesticide:
Pests Controlled:
Registered Uses:
Predominant Use(s):
Mode of Activity:
Single active ingredient
(a.i.) formulations:
Method(s) of Application:
Non-systemic fungicide for soil and
seed treatment.
Plant diseases.
Field crops, vegetables, turf,
ornamentals, seed treatment.
Cotton, turf, cabbage, seed treatments,
peanuts.
Strong suppression of growth of plant
pathogenic fungi
A 75% wettable powder, an emulsifiable
concentrate (23.4 - 26.5% a.i.), granu-
lars (2 - 30% a.i.), a flowable
(20% a.i.) & a liquid (24% a.i.). Two
dust formulations (10 & 20%) for certain
planter box uses; 80 & 90% dust for
manufacturing use. Technical grade
PCNB available at 95 to 99% a.i.
Primarily applied as spray or granular
preparations to soil.
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Cl
Cl
Cl
Cl
Cl
hcxachlorobcozent
(HCB)
"
Cl
Cl
Cl
2,3,4,5.6-p«ncachloroanilin«
(PCA)
H
2f3,4,2t6-?«neachlorob«aztnt
(PCB)
M02
2,3,4,5-ttcrachlorotii crabe:
(2.3,4,S-T01B.)
S-CB3
S-««chyl p«ne«chl9roph«nyl sulfid*
(MPCPS)
H
S-CH2-C-COOK
N-C-CH
ci -ei "6
M-acacyl-S-pancachlorophtnyL-L-cys::
Figurt 1. Chtmieal scrueeurts of PCNB lapuricits and various
PCfB a«cabolicc<
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Regulatory History
Pentachloronitrobenzene (PCtfB) is a non-systemic fungicide
primarily used to treat soil, seed, transplanted seedlings and
turf.
A Special Review (formerly known as Rebuttable Presumption
Against Registration [RPAR] process) of products containing PCNB
was initiated by the Agency on October 20, 1977 (42 FR 56072).
The Special Review was initiated based on the oncogenic potential
of PCNB, and the Agency subsequently included hexachlorobenzene
(HCB), a major contaminant of PCNB, in its consideration of the
fungicide's oncogenic potential in mice.
During the Special Review process, the Agency discussed with the
PCNB registrants various exposure and risk reduction measures.
As a result of these discussions several risk reduction measures
were identified and the registrants agreed-to implement these
measures.
The Agency agreed to terminate the Special Review on the condition
that the risk reduction measures identified were implemented. All
PCNB registrants agreed to implement the following: (1) to reduce
the level of HCB contaminant to 0.5% by April 1983, and to 0.1%
or less by April 1988, in technical grade PCNB (a progress report
was to be submitted at the end of each year summarizing efforts
to implement HCB reduction technology); (2) to perform a
residue study on processed potatoes; (3) to voluntarily cancel
the registrations of all end-use products containing dus.t-based
formulations with the exception of those used as planter box
seed treatments; (4) to submit data showing that remaining dust
based formulations for which there currently are no alternatives,
and all wettable powder formulations have been modified in such a
way that the formulations per se, packaging of the formulations,
and/or the use pattern will not result in unreasonable adverse
effects to the pesticide applicator; (5) to submit a worker
exposure study to demonstrate reduced exposure to PCNB; and,
(6) to amend labels to include directions that would reduce
exposure to humans.
On April 28, 1982, a Notice of Determination Concluding the Special
Review of PCNB (47 FR 18177) was published. The Notice announced
the Agency's regulatory decision on PCNB and the risk reduction
measures outlined above. The Agency's position on PCNB was that
the available evidence did not-clearly establish a correlation
between exposure to PCNB itself and oncogenicity. With regard
to the contaminant, HCB, the Agency described HCB as an animal
carcinogen that appeared likely to be responsible for any
potential oncogenic effect of commercial PCNB, and the Agency
concluded that reducing the level of this impurity in PCNB would
be essential to reducing any potential risks posed by PCNB
products.
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This decision was challenged in a lawsuit by the Natural
Resources Defense Council, Inc., (NRDC) for the following reasons
the lack of discussion in the Notice announcing the termination
of the Special Reivew on PCNB to support the safety of the
contaminant HCB at the present 0.5 percent level; and, that no
numerical risk assessments were completed for PCNB and HCB in
the Agency's Notice and the teratogenic and mutagenic potential
of PCNB and HCB. Subsequently, a settlement agreement was
reached with NRDC by which the Agency agreed to reassess its
regulatory decisions regarding PCNB by December 31, 1986.
On May 8, 1985 the Agency issued a PCNB Data Call-in Notice in
which the registrants of PCNB products were required to submit
the following: (1) a description of the new manufacturing
technology to attain the HCB level in PCNB to 0.5 percent;
(2) an annual progress report summarizing their efforts to
attain HCB reduction to 0.1%; (3) a residue study of
PCNB and HCB levels in potatoes after processing; and
(4) chronic feeding studies.
In response to the Data Call-in Notice, Ouimica Organica
submitted certain PCNB data which were reviewed by the Agency.
On March 31, 1986, the Agency notified the registrant that
certain data were found to be inadequate and the following
additional data had to be submitted by June 1986: manufacturing
process, formation of impurities, analysis of samples,
certification of limits, and analytical methods. These data
were submitted and reviewed by the Agency.
On September 15, 1986, the Agency notified the Ouimica Organica
that certain product chemistry data were found to be inadequate
arid additional data must be submitted: manufacturing process,
formation of impurities, preliminary analysis of product
samples, certification of ingredient limits, and analytical
methods to verify certified limits.
Uniroyal Chemical Co., Inc., and other companies cooperating
in the submission of the potato processing study have been
informed by the Agency that the study is inadequate and must
be redone. They have the options of submitting adequate
data, removing the potato use from the label, cancelling their
product, or requesting a hearing. If the registrants do not
accept any of these options, their products will be suspended.
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III. AGENCY ASSESSMENT
A. Summary
The Agency has reviewed all data submitted to support the
reregistration of pentachloronitrobenzene (PCNB). Based
on the review of these data, the Agency has reached the
following conclusions. Section B of this part includes a
detailed discussion of the reviews of specific data.
1. Hexachlorobenzene (HCB) is a contaminant of technical
grade PCNB. Prior to 1982, PCNB contained an impurity
level of 1.5% to as high as 11% HCB. By April 1983,
PCNB contained an impurity level of 0.5% HCB. Registrants
of PCNB have agreed as a condition of continued registration
to reduce the level of HCB to 0.1% or less by April 1988.
2. HCB has been classified by the Agency as a Group B2
carcinogen (a probable human carcinogen) on the basis
of increased incidences of hepatic' tumors in rats,
mice, and hamsters.
3. PCNB has been classified by the Agency as a Group D
carcinogen (an agent with inadequate animal and human
evidence of carcinogenicity). After evaluating previously
conducted chronic testing of PCNB in mice, the Agency
concluded that the observed oncogenic effects associated
with commercially produced PCNB were likely to have
been caused by the presence of the contaminant, HCB.
4. Historically, levels of HCB in technical PCNB ranged from
1.5% to 11%. Currently, levels must be no higher tha
0.5%. The Agency has calculated exposure- and risk
estimates for applicators of PCNB and the general
public exposed to PCNB in the diet assuming 0.5% and
0.1% levels of HCB. It was assumed that gloves were
worn during the mixing-loading operation as required
by the label.
a. The average exposures are the following:
1) Average dermal exposure of applicators to
PCNB (with a 0.5% HCB contaminant level)
is estimated to range from 7.4 x 10~5
to 1.7 x 10~6 mg/kg/day; and with a 0.1%
HCB contaminant level, is estimated to range
from 1.5 x 10~5 to 3.5 x iQ-7 mg/kg/day.
2) Dietary exposure to HCB from primary and
secondary residues is estimated at
4.6 x 10~5 mg/kg/day.
8
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b. The associated risks are the following:
1) The upper bound dermal oncogenic risks to
users during mixing and loading and/or
handling of PCNB with an HCB contaminant
level of 0.5% is estimated to range from
10~4 to 10~6; and with a 0.1% HCB contaminant
level is estimated to range from 10~^
to 10~7.
2) The 95% upper bound for increased oncogenic
risks in the human diet from residues of
PCNB with an HCB contaminant level of 0.5%
is estimated to be 10~5; and with an HCB
contaminant level of 0.1% is estimated to
be 10-6.
5. Since PCNB does not meet the Special Review criteria
for oncogenicity, the Agency will not place PCNB
into Special Review at this time. The. risk estimates
for PCNB, with 0.1% HCB contaminant level, for applicators
ranged from 10"^ to 10"^ and were based on 100% dermal
absorption (in the absence of data). Once the chronic
toxicity data required in this Standard are submitted and
reviewed, the Agency will determine if further regulatory
action is needed.
6. Review of the available FDA surveillance data on residues
indicates that HCB is not frequently found in the
presence of PCNB and vice versa, suggesting that
recent usage of PCNB may not be a major source of
dietary HCB.
7. Available data indicate that HCB may be associated
with developmental toxicity effects observed at high
doses in studies using PCNB contaminated with HCB.
8. Available data indicate that the No Observable Effect
Level (NOEL) for PCNB is greater than 500 ppm for
reproductive effects in rats.
9. While the data base is generally inadequate for under-
standing the environmental fate of PCNB, the available
information on leaching do not indicate that PCNB is
likely to contaminate groundwater.
10. The absence of appropriate environmental fate and non-
target data precludes an assessment of hazard to
endangered species. Label precautions required in
this Standard should be adequate to protect fish and
aquatic invertebrates while these data are being
generated.
11. Registrants must use PCNB with no higher than 0.1%
HCB for the toxicology and avian effects testing
required in this Standard.
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B. Preliminary Risk Analysis
To assess the risks associated with exposure to PCNB, the
Agency reviewed existing oncogenicity studies. Based
on the results of these studies and available exposure
information, dietary and applicator exposure and risk
estimates have been calculated. This section presents
a discussion of the toxicology studies for PCNB and
HCB, dietary exposure and risk estimates, and applicator
exposure and risk estimates.
There are numerous studies on the effects of PCNB contaminated
with HCB at varying concentrations showing both positive
and negative results. Although the presence of the contaminant
complicates interpretation of these results, it appears that
the HCB contaminant could be responsible for the oncogenic
results. However, additional data are needed to adequately
assess the oncogenicity of PCNB.
1. PCNB Oncogenicity Studies
a. Rats
There are two studies relating to the oncogenicity
of PCNB in rats. Male and female rats were
fed diets containing 0, 100, 400, or 1200 ppm
PCNB (2.7% HCB) for two years with no increased
incidence of tumors (114223)^- However,
mortality was greater than 50% in all groups
by the end of the study, only 20 of the 50
animals of each sex in each group were examined
microscopically, and many tumor diagnoses
were made grossly. No individual animal data
or historical control data were included in
the report. In addition to these limitations,
the reported results suggested that a NOEL
was not established in this study. The study,
classified as supplementary, cannot be used
by itself to support the NOEL or Lowest Effect
Level (LEL) for chronic toxicity in rodents,
and does not fulfill applicable Agency data
requirements.
In another study, male and female rats were given
diets containing PCNB (HCB content was specified
as <3%) for two years (114226). Dosages were
expressed as time-weighted averages because
of frequent changes in the dietary concentration
of PCNB during the course of the 78-week
The number in parentheses is a unique identification number
assigned to each study. This number aids in identifying the
bibliographic citation for a specific study.
10
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treatment period. For males those doses were
approximately 5000 and 10,000 ppm, and for
females they were 7875 and 14,635 ppm. The
treatment groups were maintained on control
diets for the last 33 to 35 weeks of the study.
There was an increase in pituitary chromophobe
adenomas in male rats. The study report described
the tumor as age-related, but no historical
data for untreated rats of the same age and
strain were presented. Removal of rats from
treatment for the 33 to 35 weeks of the study,
substantial dose changes throughout the study,
and the absence of individual animal results
restrict the use of this study in the assessment
of PCNB' s oncogenic potential in rats. This study
was also classified as supplementary and is
inadequate to fulfill applicable Agency data
requirements.
The Agency has concluded that available data are
inadequate to evaluate the oncogenic potential
of PCNB in rats. An additional oncogenicity
study in rats is required.
b. Mice
There are five studies relating to the oncogenicity
of PCNB in mice. In a 1969 oncogenicity study
(05010016), two strains of mice [(C57BL-6 x
C3H/Anf) Fl and (C57B1/6 X AKR) Fl] were given
464 mg/kg PCNB by stomach tube at seven to 28
days of age and there after in the diet at 1206
ppm up to necropsy at 78 weeks. A significantly
elevated incidence of liver tumors was found in
the treated C57B1/6 x AKR F^ males. Ten of 17
(59%) treated males compared to 1 of 17 (6%)
control males had hepatomas (p<0.002). The
purity of the PCNB sample was not reported.
In a 1978 mouse study (114226), the time weighted
average dietary levels for male B6C3F1 strain
mice in the low and high dose groups were approxi-
mately 2600 and 5200 ppm PCNB (<3% HCB), respectively
For female B6C3F1 strain mice the dietary levels
were 4100 and 8200 ppm in the low and high dose
groups, respectively. Six months after the
beginning of the study, 27% of the low dose group
males and 70% of the high dose group males exhibited
a hunched appearance which persisted in the
survivors until the end of the study. Body weight
decreased in treated female mice after week 35
of the study.
11
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The incidence of hepatocellular carcinomas in
female mice was 0/20, 0/14, and 3/20 in the
control, low dose group, and high dose group,
respectively. These results exhibited a
statistically significant linear trend (p=0.04;
Cochran-Armitage Trend Test), but the Fisher's
Exact Test showed no statistically significant
difference between the high dose and control
groups. The authors noted that historical
control data showed that female mice of the
same age exhibited a 1% incidence of hepatocellular
carcinoma (3/380) in the laboratory where the
test was conducted. They also pointed out
that there were a small number of animals examined
in this study. No other increases in tumor
incidence were observed in treated groups of
mice. Although there was an increase in
hepatocellular carcinomas (statistically
significant trend), mortality in treated mice
was considered excessive, and the study was
repeated.
In the repeat study (GS128-003) conducted by
the National Toxicology Program (NTP) in
1986, PCNB (<0.07% HCB) was given to male and
female B6C3F^ strain mice at dietary concentra-
tions of 0, 2500, or 5000 ppm for two years.
No increase in the incidence of neoplastic
lesions was observed in treated mice, but the
female mice of the high dose group contracted
bacterial infection which decreased survival
after the 86th week. No increased tumor
incidences were observed in treated mice
under the conditions of the experiment.
The results of a fourth study (1142J4) were used
to calculate the potency factor (Q^ ) used
in the risk assessment presented in the Special
Review document for PCNB (Position Document 1).
Diets containing 0, 100, 400, or 1200 ppm
PCNB (2.7% HCB) were fed to male and female
Swiss mice for 80 weeks. The incidences of
subcutaneous fibrosarcomas in female mice were
0/98, 2/100, 2/100, and 11/99 for the control,
low, mid, and high dose group females, respectively,
The tumors primarily occurred in the high
dose group females, and a few were diagnosed
earlier in that group than in any of the
other treated groups. The only other skin
lesions reported were abscesses. Fibromas were
not mentioned in the repprt.
12
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There were no individual data reported in this
study, and results in some cases were presented
as group means with no indication of the
variation observed in each group. Time-to-
diagnosis data were limited to general time
periods instead of individual times (days of
the study) of diagnosis. These limitations do
not permit a complete evaluation of observed
tumor incidences. However, the data as presented
suggest that subcutaneous fibrosarcomas are
likely to-be the result of treatment.
Finally, the Agency's Special Review considered
a tumor initiation study in mice (Searle,
1966) (42 FR 56072, October 20, 1977). PCNB
dissolved in acetone was applied to shaved
skin twice weekly for 12 weeks. The percentage
of HCB in the PCNB administered to the mice
is unknown. These mice then received appli-
cations of croton oil on the same skin area
for 20 weeks. During the 20 weeks of croton
oil treatment and for 20 weeks thereafter,
the total number of tumors and the number of
mice bearing visible tumors were noted.
Papillomas less than 1 mm in diameter or
persisting for less than three weeks were not
counted. Mice from treated and untreated groups
began to develop papillomas after 5-8 weeks
of croton oil treatment. Papillomas increased
in number until 5-10 weeks after the last croton
oil applications, and some papillomas regressed.
Seven treated males had tumors as compared to
only one in the control group. Also, 14 of
20 treated males and females (combined), compared
to 5 of 20 untreated males and females (combined)
had papillomas.
2. HCB Oncogenicity Studies
HCB has been shown to increase the incidence of liver
tumors in rats, mice, and hamsters. Data regarding
the carcinogenicity of hexachlorobenzrene in humans
could not be located in the available literature.
Animal data on HCB were evaluated by the Office of
Research and Development and Office of Emergency
and Remedial Response, U.S. .Environmental Protection
Agency. The results of this data evaluation were
published in the document entitled "Health Effects
13
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Assessment for Hexachlorobenzene", September
1984 (U.S.EPA)^/. The information presented on the
o~hcogenicity studies on HCB' in this Registration
Standard document is taken from that previously
published report.
a. Rats
Smith and Cabral (1980 ) Vexposed female MRC Wistar
and Agus rats to 100 ppm hexachlorobenzene in
their diets for 75 and 95 weeks, respectively.
There was an increased incidence of liver tumors
in both sexes of' rats, but an evaluation of the
statistical significance was not presented in
the literature. Among hexachlorobenzene-exposed
MRC Wistar rats, 4/6 developed liver cell
tumors, compared to 0/4 of the control group;
14/14 treated Agus rats developed liver cell
tumors, compared to 0/12 in the control group.
More recently, Lambrecht e_t al. (1983a,b)V fed
groups of 94 male and 94 female Sprague-Dawley
rats diets containing 0, 75, or 150 ppm
hexachlorobenzene. Interim sacrifices for
histopathological examination were performed
on 4 rats of each sex/group at 10 intervals
up to 64 weeks of treatment. The remaining 58
rats/group were allowed to continue to natural
death or until 2 years of treatment. The
number at risk was considered to be those survi-
ving at least 12 months, as this was the earliest
time to tumor observed.
Based on an average (weighted) food consumption
of 22.6 and 16.*5 g/rat/day for males and
females, respectively, with average adult
body weight of 400 and 265 g, the low dose was
determined to be 4-5 mg/kg/day and the high
dose, 8-9.5 mg/kg/day. The incidences of
tumors observed in this study are^presented in
Table 1. The most striking observations
were the high incidences and dose-related
incidences of hepatocellular carcinomas in female
rats and renal cell adenomas in male rats.
In an earlier study, Lambrecht e_t a_l (1982)V
exposed rats to dietary concentrations of 0,
200, or 400 ppm hexachlorobenzene for 90
days. The authors associated treatment with
an increased incidence of liver neoplasma,
generalized lymphatic leukemias and a variety
of renal lesions.
U.S. Environmental Protection Agency, Office of Research &
Development, Office of Emergency & Remedial Response (1984)
Health Effects Assessment for Hexachlorobenzene, (EPA/540/1
86-017, Contract No. 68-03-3112, Published study)
14
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Table 1
liver and Kidney TMMTS In Sprafve-Dawley Mats Given Hexachlorobenzene In the Dlelt for up to ? years*
Ixposure
level
0
Percentafe
7S ppm
Percentafe
ISOpp.
Percentafe
HepatoM
N f
0/S4 0/52
0 0
10/52 ?ft/Sft
19 4ft
11/Sft 35/55
20 ft4
Hepatocellnlar
Carcinoma
M f
0/54 0/52
0 0
3/52 36/56
ft 64
4/56 48/55
7 07
Renal Cell Renal Cell
Adenoma Care tnomi
N F N
7/54 1/5? 0/54
13 ? 0
41/52 7/56 0/5?
7$ 13 0
42/56 1S/S4 0/56
75 20 0
F
1/52
2
2/46
4
2/54
4
•Source: iMfcrecM et al.. 1983a.b
15
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,b. Mice
Ibid.
Cabral et al (1979)^/ exposed Swiss mice of both
sexes to dietary concentrations of 300, 200,
100, 50, or 0 ppm hexachlorobenzene for 15,
101, 106, 120, or 120 weeks, respectively.
An increased incidence of liver cell tumors
was observed at dietary concentrations >^ 100
ppm hexachlorobenzene. Liver cell tumor
incidences were 1/16 for males, 1/26 for
females; 7/44 for males, 14/41 females; 3/29
for males, 3/30 for females in groups exposed
to 300, 200, or 100 ppm hexachlorobenzene,
respectively. Liver cell tumors were not
observed in mice exposed to 0 or 50 ppm
hexachlorobenzene. No other tumors were
reported as having increased incidences in
either sex.
Cabral et al. (1977)3_/ fea diets containing 0,
50, 100, or 200 ppm hexachlorobenzene to
Syrian golden hamsters for life. These diets
resulted in increased rates of alveolar (sic)
adenomas of the thyroid, hepatomas of the
liver and hemangioendotheliomas of both the
liver and spleen in male and female hamsters.
The incidence of total tumor-bearing animals
appeared to be dose-related: 10% of the control
group, 56% of the low-dose group, and 75% of
the middle-dose group and 92% of the high-dose
group developed tumors. Tumor incidence data
were highly significant.
c. Other Relevant Data
3/
According to the U. S. EPA (1984), mutagenicity
has been observed in Saccharomyces cerevisiae
at a minimum concentration of 100 ppm. Lawlor
et al. (1979) tested the mutagenic activity of
hexachlorobenzene in Salmonella typhimurium
strains TA98, TA100, TA1535, TA1537, and
TA1538, with and without activation by Aroclor
1254, induced rat hepatic microsomes. Hexachlorobenzene
was associated with no detectable mutagenicity
in any of the strains tested, with or without
metabolic activatin. Dosage levels were unspecified.
16
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In a dominant lethal assay male rats were treated
with 0, 70 or 221 mg hexachlorobenzene/kg by
gavage for 5 consecutive days. A dose related
depression of male reproductive function occurred,
.but dominant lethal mutations were not observed
(Simon et al.. , 1979). Khera (1974) also reported
a lack of dominant lethal mutations in Wistar
rats following gavage administration of 0, 20,
40 or 60 mg hexachlorobenzene/kg for 10 consecutive
days.
Weight of Evidence: PCNB and HCB Oncogenic Potential
a. PCNB
Although there are a number of oncogenicity studies
using PCNB as the test substance in which oncogenic
effects were observed, the Agency believes
based on several mouse studies involving PCNB with
different levels of HCB that it is likely that
HCB, a contaminant in PCNB, is responsible for
the observed oncogenic effects. Some studies
with PCNB are reportedly negative, but all of
these studies, except for the new NTP study
(GS128-003), are limited in some way and thus
the Agency cannot rely on them to characterize
the oncogenic potential of PCNB. The Agency
has reviewed a negative mouse study conducted
with relatively pure PCNB (0.07% HCB) that is
considered valid and a number of valid mutagenicity
studies. A rat study and additional mutageni-
city data must be submitted to completely assess
the oncogenic potential of PCNB. For these
reasons, the Agency has classified PCNB in
Group D, not classifiable as to human carcinogenicity,
according to the Guidelines for Carcinogen Risk
Assessment (51 FR 33992).
These guidelines describe the general framework
to be used in developing an analysis of carcinogenic
risk with regard to assessing the weight of evidence
of carcinogenicity from human and animal studies.
Based on the weight-of-evidence analysis of available
data, chemicals are categorized with regard to their
potential human carcinogenicity. Under EPA's
classification system, Group A, "Human Carcinogen,"
17
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is reserved for those chemicals fro which there is
sufficient evidence of carcinogenicity from human
epidemiological studies. Group B, "Probable
Human Carcinogen," is divided into subgroups 1
and 2. Group BI requires some human epidemiological
evidence.
Under the carcinogen risk assessment guidelines,
chemicals are categorized as Group 82 carcinogens
if there is "sufficient evidence" of the chemical's
carcinogenicity from animal studies. By comparison,
Group C ("Possible Human Carcinogens") chemicals
are so classified if these is "limited evidence"
from animal studies. There is also a Group D
("Not Classified") and a Group E that is reserved
for chemicals shown to be non-carcinogenic in animal
and/or human studies.
Two of the four mouse feeding studies using PCNB
were positive for oncogenicity. One study
(5010016) utilized PCNB thought to contain 11%
HCB. The Agency has- noted (U. "S. EPA, 1984)V
that dietary levels of 100 ppm HCB or greater
increased the incidence of liver cell tumors
in mice. A dose level of approximately 1200
ppm PCNB (including approximately 130 ppm HCB)
was tested by Innes et al. (5010016), and the
investigators diagnosed liver tumors. Therefore,
the first positive study cannot be used to
associate an oncogenic response in mice with PCNB.
Another positive study (114224) was conducted
with PCNB containing 2.7% HCB (equivalent of
approximately 130 ppm), and fibrosarcomas
were the only tumors increased by PCNB treatment.
This study was reported in summary form, and
additional data (including historical control
data on the incidence of skin tumors in the
strain of mice tested, the incidence of fibromas
in this study, and individual animal body weights
and day of death during the study) have been
requested to support a more complete evaluation
of the results (Gardner, 1986).
Although two long-term rat feeding studies with
PCNB (containing approximately 3% HCB) were
negative (114223 and 114226) these data are of
limited value. There was excessive mortality
in all groups and microscopic examinations
were incomplete in the first study, and the
second study tested excessively toxic doses
which were substantially changed throughout
the experiment and withdrawn for the last 33
to 35 weeks of the two-year, study. Microscopic
examinations of test animals in the second
study were also limited.
3 Ibid.
18
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Ibid.
In addition, the level of HCB contamination in
both PCNB rat studies was greater than lowest-
observed-effect levels (LOEL) described by
the Agency (U. S. EPA, 1984)2/for HCB alone.
In one PCNB study (114223) the highest dietary
level of HCB was 2.7% of 1200 ppm or 32 ppnt,
and in the other PCNB study (114226), the
highest HCB level was approximately 300 ppm
for males and 440 ppm for females. However,
LOEL's in rats exposed to HCB ranged from 40
to 32 ppm with effects such as hepatic enzyme
induction, increased cytochrome P-450, body
weight loss, and mortality in female rats.
Increased incidences of hepatocellular carcinomas
in female rats-and renal cell adenomas in male
rats were seen after chronic feeding of diets
containing 75 ppm HCB or more (U. S. EPA, 1984).
In the National Cancer Institute's (NCI) mouse
study of PCNB containing <3.0% HCB (114226),
which was negative for oncogenicity, excessive
mortality was observed. Substantial dose changes
were made during the experiment. The study was
repeated by the National Toxicology Program
(NTP) in the same strain of mice (B6C3F1)
(NTP, 1986) with PCNB containing <0.07% HCB.
The test substance predisposed the female
mice of the high dose group (5000 ppm) to a
bacterial infection which decreased survival
significantly after the 86th week of the study.
No increased tumor incidences were observed
in treated mice under the conditions of the
experiment. This study is an acceptable study
for assessing the oncogenic potential of PCNB
in mice.
A tumor initiation study described in the
Agency's Notice of the Special Review for PCNB
(Searle, 1966) (42 FR 56072) suggested that
the test substance induced skin tumors (papillomas)
in male and female mice. The study did not
specify the purity of the PCNB tested, and it
was conducted at a time when available PCNB
was probably contaminated with considerable
amounts of HCB (2.7 to 111).
The Agency concluded in its Special Review of PCNB
that the majority of evidence on mutagenicity
was negative. In subsequent studies (NTP,
1986) a chromosomal aberration assay in CHO
cells suggested that the test substance has an
19
-------
effect on chromosome structure. Because there
were no genotoxlc effects other than chromosomal
aberrations and because those effects were not
clearly dose related, the NTP report concluded
that further cytogenetic studies, both iri vivo
and in vitro, would be required to characterize
the genetic toxicity of PCNB.
The following factors support the conclusion
that there are not sufficient data to assess
the oncogenic potential of PCNB.' Additional
oncogenic data Are required in the rat along
with further mutagenicity tests to complete
the oncogenicity assessment.
1. The PCNB used in many of the relevant studies was
contaminated with HCB which the Agency has classified
as a probable human carcinogen (Group 82) on the
basis of increased incidence of hepatic tumors in
rats, mice, and hamsters. The contaminant has a
potency factor (Q-^*) of 1.7 (mg/kg/dayJ'1.
2. Excessive toxicity or generally low survival of
test animals in the long-term rat feeding studies
makes them inadequate for use in an assessment of
PCNB's carcinogenic potential. (The Agency does not
expect to receive a new chronic rat toxicity study
until July 1991.)
3. A 2-year mouse feeding study with PCNB containing
<0.1/6 HCB was negative for oncogenicity.
4. Additional information (historical control data on
the incidence of skin tumors in the strain of mouse
tested and individual animal body weights and day
of death during the study) has been requested on
the mouse oncogenic-ity study demonstrating an
increased incidence of fibrosarcomas in females
given PCNB (2.7% HCB) to completely evaluate the
results of the study.
5. Most of the available mutagenicity studies on PCNB
suggest that it is not mutagenic. One study reported
by the NTP (1986) suggests that the test substance
has an effect on chromosome structure, but additional
studies are being done by the NTP to confirm those
results.
20
-------
Thus, according to the criteria for evaluating the
overall weight of evidence of carcinogenicity to humans
developed by the Carcinogen Assessment Group of the
U.S. EPA (51 FR 33992), PCNB is most appropriately
classified in Group D, not classifiable as to
human carcinogenicity. This classification group
is used for chemicals with inadequate human and
animal evidence of carcinogenicity or for which no
data are available.
b. HCB
Reports of carcinogenicity of hexachlorobenzene
in humans could not be located in the
available literature. Smith and Cabral
(1980) demonstrated a compound-related
increased incidence of liver cell tumors
in female MRC Wistar and Agus rats exposed to
dietary levels of 100 ppm hexachlorobenzene
for 75 or 95 weeks. Liver neoplasms were
observed in rats exposed to 200 or 400 ppm
hexachlorobenzene for 90 days (Lambrecht et
al. , 1982) and liver and kidney tumors
were noted in rats exposed to 75 or 150 ppm
in the diet for up to 2 years (Lambrecht
e_t a_l. , 1983a,b). At dietary levels of
XLOO ppm for 106 weeks, Swiss mice showed an
increased incidence of liver cell tumors
(Cabral et al., 1979). Finally, Cabral'et
al. (1977) demonstrated significant increases
in the incidences of alveolar adenomas of
the thyroid, hepatomas of the liver and
hemangioendotheliomas of both the liver
and spleen in Syrian golden hamsters exposed
to hexachlorobenzene. These animal studies
provide sufficient evidence that hexachlorobenzene
is an animal carcinogen.
Thus, according to the criteria for evaluating
the overall weight of evidence of carcinogenicity
to humans developed by the Carcinogen Assessment
Group of the U. S. EPA (51 FR 33992)
hexachlorobenzene is most appropriately
classified in Group B2, probable human
carcinogen.
4. PCNB - HCB Dietary Exposure and Risk Assessment
\
\ The Agency determined in 1982 that use of PCNB could
continue if registrations were amended to reflect
the lower HCB contamination levels, but a dietary
risk assessment was not performed at that time.
A dietary exposure and risk assessment was done for
21
-------
inclusion in this Registration'Standard but the
reliability of the estimates is limited by the quality
of data available.
At the time the Special Review on PCNB was terminated,
the PCNB registrants agreed to reduce the level of
HCB in technical PCNB. By reducing the HCB level
from 1.5% to 0.5%, the dietary burden is reduced three
fold. By subsequently reducing the HCB contamination to
0.1%, the dietary burden and risk is correspondingly
reduced further by a factor of 5.
The dietary exposure analysis summarized in Table B-2 is
based on the following assumptions:
0 The level .of HCB contamination is 0.5%, the current
maximum under the conditions for registration established
at the termination of the Special Review.
0 Primary residue values used for raw agricultural
commodities (RAC's) are the highest values expected
from available field trials.
0 In instances where current labels permit application
values higher that those used in the field trials,
it is assumed that the higher application rate is
generally used.
8 The recent history of use on crops is a predictor
of future usage (Torla, 1986).
0 In the case of bananas, the Agency has no residue
data, no estimate of percent of crop treated and
no bioconcentration data for HCB. From 1979 to
1985, however, the Food & Drug Administration
(FDA) did not detect either PCNB or HCB residues
in imported bananas (RGB Addendum, August 1, 1986).
For small grains, no residue data from field trials
were available, but the FDA detected res'idues in
12 samples of wheat from 1979 to 1985. (It should
be noted that no FDA data are presently available
regarding the total number of samples analyzed
using methods capable of determining residues of
PCNB. Therefore, the actual significance of the
monitoring data cannot be determined.) Thus, we
assume that residue contributions from these RAC's
will not have a substantial effect on the total
exposure.
o
It is assumed that cattle and poultry are fed maximum
dietary levels of RAC's contaminated with highest
expected residues of HCB, corrected for percent of
crop treated.
22
-------
The analysis in Table 2 suggests that 97% of the dietary
exposure is derived from secondary residues in meat,
milk, poultry and eggs, making the underlying assumptions
for this source critical. A comparison of the amount
of cottonseed required to feed cattle at the maximum
theoretical rate with that which is actually available
for use as a feed indicates that only about 4.0% of
the required seeds is available. A consideration of
other RAC's and livestock would yield similar results.
Therefore, in Table 2, the estimate of 4.4 x 10
for secondary residues is multiplied by 4% to give 2 x
10~6 mg/kg/day (Barbehenn, Dec. 12, 1986).
Combined with primary residues an^ multiplied by
the oncogenic potency for HCB [Qi is 1.7 (mg/kg/day)~^],
the 95% upper bound for increased oncogenic risk is 6 x
10~6 for PCNB contaminated with 0.5% HCB. At 0.1%
HCB contamination, exposure would be reduced 5-fold
and the risk would be 1 x 10~6. Prior to the 1982
decision, the risk would have been 2 x 10~5 with
an HCB contamination of 1.5%.
23
-------
Crops
Table 2. Dietary Exposure from 0.5% HCB i.n PCNB
Max. expected!/ % of crop Food^/ Exposure x 106
residue (ppm) treated Factor (%) (mg/kg/day)
Primary Residues
Cottonseed
Peanuts
Beans
Broccoli
Brussel
sprouts
Cabbage
Cauliflower
Garlic
Peppers
Potatoes
Tomatoes
SUBTOTAL
0.009
0.14
0.02
0.0021/
0.0021/
0.002
0.0021/
NA
0.001
0.07
0.001
11 0.15
<5 0.36
4 0.98
<1 0.10
13 0.03
11 0.74
8 0.07
14 0.03
12 0,12
<1, 5.43
1 2.87
0.04
0.6
0.2
0.0005
0.0002
0.04
0.003
NA
0.004
0.95
0.007
1.8 x 10"6 mg/kg/day
Secondary Residue!/
Cattle
Milk
Poultry
Eggs
SUBTOTAL
TOTAL
0.02
0.0008
0.003
0.0004
7.18
28.62
2.94
2.77
36
5.7
2
0.3
4.4 x 10-5 mg/kg/dai
4.6 x 10~5 mg/kg/dav
NA - Not Available
I/ - Derived from Hummel (August 8,1986) and corrected for maximum allowable
application rates as described in the text.
2/ - The food factor is the percentage of a 1.5kg .daily diet represented by a
given crop.
3/ - Assumed to be the same as cabbage.
4/ - Derived from Hummel (Dec.4,1986); assumes percent of crop treated for
feed RAC's.
24
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5. PCNB & HCB Applicator Exposure and Risk Assessment
a. The Agency has evaluated numerous publicly available
scientific articles on exposure monitoring for
pesticide work activities similar to those employed
in the application of PCNB (referred to as surrogate data)
These studies were used to estimate exposure
to HCB according to established exposure assessment
procedures. The results of an applicator exposure
study submitted by the registrant was reviewed
and found to be inadequate because there were
not enough replicate samples. However, the results
from this study, where comparable, are consistent
with the results obtained from the surrogate
data base used for this assessment.
b. Calculation Assumptions: The following assumptions
apply to the three major use patterns: planter
box, turf and transplant.
1) Respiratory exposure is insignificant compared
to dermal exposure for the three uses.£/
2) Gloves are worn by workers using PCNB during
mixing-loading operations only (required
on label); and gloves with long pants and a long
sleeve shirt reduce total dermal exposure
80%. V
3) Dermal absorption is assumed to be 100%.
4) Exposure is assumed to be amortized over
365 days for 40 working years of a 70 year
lifetime ([LADD] lifetime average daily
dose).
5) HCB contamination levels are assumed to be
0.5% and 0.1% (wt HCB per wt PCNB)as required
for continued registration.
f_/ Protection of this type is assumed to reduce exposure to covered
body areas about 80% because some pesticide will penetrate
the material or filter in around edges or hems of clothing.
Waldron, A.C. "Minimizing Pesticide Exposure Risk for the
Mixer-Loader, Applicator, and Field Worker", Dermal Exposure
related to Pesticide Use, ACJ Symposium Series 273, 1985, pp.413-415
\f Maddy et al., "Risk Assessment of Excess Pesticide Exposure to
Workers in California." ACS Symposium Series 273, 1985, pp.445-461.
25
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c. Surrogate Data Bases
1) Mixing and Loading Solid Formulations.
In the only study with sufficient information
for calculating mixing and loading exposures
there were eight replicates of exposure
during mixing and loading of a wettable
powder formulations averaged 1.1 mg/lb a.i.
Assuming 80% protection, exposure is 0.22
mg/lb a.i. with gloves.
2) Ground Boom Spraying
Six studies containing a total of 92 replicates
were evaluated and used as a surrogate
database for this assessment.
The geometric mean for exposure derived from
the studies described above was 6.3 mg/hr
normalized to 1 Ib a.i./A. (It is assumed
that exposure is proportional to application
rate. Therefore, for 2 Ib a.i./A, exposure
is 12.6 mg/hr, etc.)
d. Calculations
The exposure estimates presented below were calculated
for the three major use patterns and representative
formulations.
Sample Calculation (0.5% HCB contamination)
(Total amount of active ingredient (a.i.)) x
(number of boxes filled/yr) x (% a.i./lb. of formulation) x
(estimated exposure/lb. a.i.) x (%HCB in PCNB) x (70 kg/man) x
(365 days/year) x (40 years work life) = mg/kg/day HCB
(70 year lifetime)
1) Planter Box. 4.5 Ibs of a 20% dust is used
in each box. Eight boxes each are filled 10
times over the year. It is assumed that
exposure during the filling operation is
comparable to mixing and loading a wettable
powder (WP).
4.5 Ib form./box x 80 boxes/yr x 0.2 (a.i./form) x 0.22
mg exposure/lb a.i. x 5 x 10"3 HCB/PCNB x 1/70 kg-1bw x
1/365 yr/days x 4£ yrs work = 1.7 x 10~6 mg/kg/day HCB.
70 yr lifespan
26
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2) Turf. A 75% WP is applied at the rate of
0.75 Ib a.i./lOOO ft2 =32.67 Ib a.i./A.
Three acres are treated four times per
year for a total of 2.8 hrs. The same
individual does both the mixing and applying.
Sample Calculation (0.5% HCB contamination)
Applicator
6.3 mg exposure/hr x 2.8 hr/yr x 32.67 Ib (a.i./A correction
factor)
5 x 10-3 HCB x 1/70 kg-!bw x 1/365 yr/days x
PCNB
££ yrs working = 6.4 x 10~5 mg/kg/day HCB.
70 yr lifetime
Mixer/loader
32.67 Ib a.i./A x 12 A/yr = 392 Ib a.i./yr
0.22 mg exp./lb a.i. x 392 Ib a.i./yr x 1/70 kg bw x
5 x 10-3 HCB 1/365 days/yr x 40 yrs work =
PCNB 70 yr lifetime
9.6 x 10~6 mg/kg/day
Total Exposure = applicator plus mixer/loader exposure
6.4 x 10-5 + 9.6 x 10-6 = 7.4 x iQ-5 mg/kg/day.
3) Transplant. Assume that the bulk of total
exposure occurs during mixing/loading.
ISA is treated with a water suspension at
a rate of 7.5 Ib a.i./A once a year (total =
112.5 Ib a.i.'/yr.)
Sample Calculation (0.5% HCB contamination)
0.22 mg exp./lb a.i. x 112.5 Ib a.i./yr x 1/70 kg-1bw
x 5 x 10"3 HCB x 1/365 year/days x ^£ yrs work
PCNB 70 yr lifetime
2.7 x 10"6 mg/kg/day
27
-------
e-. Summary Table of Applicator Exposure & Risk
Lifetime Average Daily Dose (LADD) Exposure to HCB*(mg/kg/day)
0.5% contaminant 0.1% contaminant
Planter box 1.7 x 10~6 3.5 x 10-7
Turf 7.4 x 10~5 1.5 x 10~5
Transplant 2.7 x 10"6 5.5 x 10~7
Quantitative Rigk Assessment/HCB**
0.5% contaminant 0.1% contaminant
Planter box 1CT6 1CT6
Turf 10-4 10-5
Transplant 10~5 10~6
* unadjusted for dermal absorption
** 95% upper bound on the increased probability of cancer from
exposure to a probable human carcinogen [B2] with a potency
of Q! = 1.7 (mg/kg/day)'1 (U.S.EPA, 1984).
28
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C. Other Science Findings
1. Chronic Feeding Studies
In order to completely assess the data base for PCNB,
chronic feeding studies were evaluated to determine
the NOEL for PCNB' s toxicity in establishing an
acceptable daily intake (ADI) level for dietary
purposes.
a. Dogs
In a two-year- dog study (114232), males and females
were fed diets containing 0, 500, 1,000, or
5,000 ppm PCNB (purity not specified). Liver
changes occurred in all groups and the degree
of change was dose related. The 5,000 ppm level
produced fibrosis, narrowing of hepatic cells,
thick leukocytic infiltration, and increased
size of the periportal areas. At the 500 and
1,000 ppm levels, the changes were similar but
to a lesser degree. The highest level also
produced atrophy of bone marrow and reduced
hematopoiesis.
In a second two-year feeding study dogs were
administered 0, 30, 180, and 1080 ppm (114201).
The study results indicated that administration
of PCNB to dogs indicated that PCNB (1.4% HCB)
caused liver weight increases, increased liver-to-body
weight ratios, elevated serum alkaline phosphatase
levels, and microscopically observed cholestatic
hepatosis with secondary bile nephrosis at 1080
ppm (the highest dose tested). The cholestatic
changes were observed in all animals given
diets containing 180 and 1080 ppm PCNB, and one
of three male dogs in the 30 ppm dose group
exhibited the microscopic changes (no female
dogs were affected). These histopathologic
changes were moderate in the 1080 ppm group and
minimal in the 180 ppm group. - Based on these
results, 30 ppm was the NOEL and 180 ppm was
the LOEL in dogs (114201). This study satisfies
the requirement for chronic testing in a non-rodent
species.
b. Rats
In a two year rat feeding study (114223), males
and females were fed diets containing 0, 100,
400, or 1200 ppm PCNB (2.7% HCB). Mortality
was greater than 50% in all groups and only 5
to 10 animals were used to obtain group mean body
weights at the end of the study. Only 20 of
the 50 animals of each sex in each group were
examined microscopically, and many tumor
29
-------
diagnoses were made grossly. No individual
animal data or historical control data were
included in the report. In addition to these
limitations, reported results suggested that
a NOEL was not established in this study.
Therefore, this study can not be used by
itself to support the NOEL or LEL for chronic
toxicity in rodents which were suggested by
the results.
2. Developmental Toxicity
a. Rats
Ibid.
Courtney et al (114250) tested two grades of PCNB
that contained approximately 11% and 1% HCB.
Neither test substance affected maternal body
weight gain, liver-to-body weight ratio, or fetal
weights at the single dose level tested
(500 mg/kg/day). The average litter size for
dams given the PCNB containing 11% HCB was
reduced (8.2 per litter compared with 10 in
the controls) and malformations (enlarged
cerebral ventricles, umbilical hernias, and
slightly enlarged renal pelvises) occurred at a
slightly higher incidence than in control
animals. The sma-11 number of animals per
dose preclude definite conclusions.
In the Agency's health effects assessment
(U.S.EPA, 1984) of the contaminant HCB, Kher.a
(1974)3 found HCB to be toxic to pregnant
rats and their fetuses at doses of 80 and
120 mg/kg/day. A NOEL was established at 60
mg/kg/day.' This study and the marginal effects
observed by Courtney et al (114250) suggest that
HCB, an impurity of PCNB, may have a role in
the developmental toxicity of PCNB at high
doses. Deficiencies in the statistical analysis
and the apparent inconsistencies with respect
to the maternal and fetal weight data and
incidence of runts makes this rat study (114204)
unacceptable in an assessment of HCB's potential
developmental toxicity.
A third study (114199) did not include observations
such as maternal body weight and food consumption
during gestation, and there were no effects
noted at any dose (125 mg/kg highest dose
tested). The results reported by Courtney
et a_l. (114250) suggest that sufficiently
high doses were not evaluated, and this study
30
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cannot be used to assess the potential for
developmental toxicity of PCNB. Because of
the limitations associated With the three
studies above, an additional study in rats is needed.
b. Mice
The available mouse study (114250) used only
one dose and a small number of animals per dose
group. These test conditions, sufficient for a
preliminary test, preclude the use of this study
to fulfill the Agency's requirement for a teratology
test in a second species.
3. Reproductive Effects
A reproduction study (0001666) was conducted in rats
with PCNB which contained 1.4% HCB. Dietary concentrations
of up to 500 ppm (1.4% HCB) had no effect on reproduction.
Weights for parental animals were reported only at
mating and at weaning of offspring, ho food consumption
data were included, and pups were not weighed at
birth or during lactation. In addition, microscopic
examinations of test animals did not reveal effects,
but histopathological examinations were confined to
10 pups of each sex from each group in the third
generation. Despite these limitations, the study
suggests that the NOEL for reproductive effects in
rats is greater than 500 ppm. No further reproduction
data are required'.
4. Mutagenicity
The preponderance of the studies reviewed were negative
for mutagenic activity. Bacterial assays for reverse
or forward mutations, differential toxicity and DNA
repair were conducted in Salmonella typhimurium
(114206, 5009139, and 26358), Escherichia coli
(5009139, Mohn, 1971, Shirasu e_t jQ. , 1976, and Clark,
1971), and Bacillus subtilis (5009139). A mitotic
recombination assay was conducted in Saccharomyces
cerevisiae (5009139), and a recessive lethal assay
was done in Drosophila melanogaster (5003752). I_n
vitro unscheduled DNA synthesis in human fibroblast
cells (5009139); and dominant lethal assays with mice
(5009139 and 26358) were also conducted. The E_._
coli assay reported by Clark (1971) was the only
positive assay.
More recent studies were conducted in conjunction with
an oncogenicity study (NTP, 1986), and the reverse
mutation assay in Salmonella typhimurium, , an i_n
vitro assay in mouse lymphoma cells (point mutation
assay), and a sister chromatid exchange assay in
31
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Chinese hamster ovary (CHO) cells also did not show
Chat PCNB had mutagenic activity* However, a chromosomal
aberration assay in CHO cells suggest that the
fungicide has an effect on chromosome structure.
The effects were observed at doses of 7.5, 24.0, and
75,0 ug/ml both in the presence and absence of metabolic
activation. However, the authors noted that there
were no genotoxic effects other than chromosomal
aberrations, and those effects were not clearly dose
related. The NTP report concluded that further
cytogenetic studies, both ir\ vivo and ir\ vitro,
would be required to understand the genetic toxicity
of pentachloronitrobenzene.
5. Metabolism
a. Rats
The major route of excretion for PCNB and its
metabolites in rats is the feces (114207, 114208,
114209, and 114256). Eighty-five to 88% of the
administered radioactivity was recovered from
the excreta 6 days after treatment (10 to 12%
in the urine). Female rats have a more rapid
fecal excretion rate during the first 24 to 48
hours after dosing than the males.
The major metabolite in the feces was identified
as pentachloroaniline and its conjugates
(97800, 114208, and 114251). Similar metabolites
in the feces of rats treated orally and intravenously
suggested that biliary excretion occurs (114251),
but PCNB is also metabolized to pentachloroaniline
in the gastrointestinal tract as shown by in
vitro studies (114251) and in the feces without
absorption.
Analysis of tissues, feces, blood, bile, and urine
samples from rats fed PCNB for 7 months to 2
years indicated that the impurities (hexachlorobenzene
and pentachlorobenzene) and a metabolite
(pentachlorophenol) rather than PCNB accumulated
in the fat (60561).
Blood levels peaked 12 hours after oral administra-
tion of a single 5 mg/kg dose. The maximum
level observed was 0.62 ppm, and the halflife
for radiolabel in the blood was calculated to be
21.8 hours (114256). Residue concentrations in
the liver, kidney, and carcass six days after
dosage administration were reported to be
0.04, 0.16, and 0.01 ug/g of tissue respectively,
and the ratio of the residue concentrations in
plasma to those in red blood cells at 12, 60,
32
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and 144 hours after dosing were 3, 2, and 0.7,
respectively.
The overall metabolic pathway in rats (114256)
indicates that PCNB absorbed after an oral dose
is largely excreted in the form of N-acetyl-S-
pentachlorophenylcysteine (48%) or pentachloroaniline
and its conjugates (18%). Pentachlorophenol
accounted for approximately 4% of the administered
radiolabel, and methyl pentachlorophenyl sulfide
accounted for 0.2% of the administered radioactivity
(114256).
b. Dogs
Analysis of tissues, feces, blood, bile, and urine
from dogs fed PCNB for 2 years indicated that
the impurities rather than PCNB accumulated in
the fat (60561). Metabolites identified in the
feces and urine were similar to those found in
rats (60561).
c. Rhesus monkeys
Blood levels peaked first at 1.5 hours and later
at 7 hours after administration of a single 0.5
mg/kg dose of radiolabelled PCNB (114233).
Fecal and urine samples collected 24 hours after
dosing accounted for 28.5 and 21.8% of the admin-
istered activity, respectively. The respective
proportions of the dose recovered from urine
and fecal samples over the 5 days following
treatment were 39.9 and 41.5%, respectively.
The biological half-life for elimination of radio-
labelled residues of PCNB (after a single 2.0
mg/kg dose) was estimated to be 1.5 to 1.7
days, and after 14 days most of the recovered
radioactivity was found in the feces (47% of
label recovered as compared with 38% of the
administered dose). The highest concentration
of radioactive residues were found in the bile
(275.9 ppm 24 hours after dosing) indicating
that biliary excretion occurs in monkeys.
At a higher single dose (91 mg/kg), the half-life
for elimination was extended to 4 days (114233).
Approximately 60% of the administered dose was
accounted for in excreta within 20 days of the
treated-monkeys. The half-life of activity in
plasma was estimated to be 6 days.
33
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In an experiment using repeated daily doses
equivalent to 2 ppm in the diet, an equilibrium
between intake and excretion was reached after
30 to 40 doses (114233). Approximately 90% of
the administered radioactivity had been excreted
by the 71st day of the study (the day after
treatment was terminated). Ten days after
dosing was stopped (day 80 of the study) approxi-
mately 95% of the administered radioactivity
had been accounted for in the excreta. The
bile contained the highest concentrations of
PCNB residues (7.73 and 3.72 ppm in males and
females, respectively). Concentrations in the
liver, kidney, fat, bone marrow, and thymus
ranged from 0.1 to 0.2 ppm. Metabolites identified
in the urine and feces of treated monkeys are
reported in Table 1 along with the proportion of
the radioactivity they represent.
Table 3. Metabolites and the percentage radioactivity
presence in the urine and feces (118937)
14 days 20 days
after a single after a single
oral dose of oral dose of
2 mg/kg 91 mg/kg
Metabolite Urine Feces Urine Feces
Pentachloroaniline 55.2 66.0 36.0 66.2
Pentachlorobenzene 11.7 1.0 11.9 1.1
Pentachlorophenol 12.2 — 17.5
Pentachlorothioanisole 9.7 6.2 10.3 6.2
bis-methylmercaptotetra-
chlorobenzene 9.7 7.1 9.2 7.1
PCNB — 16.3 — 12.9
6. Dermal Absorption
The amount of radiolabelled PCNB excreted by rats
during a 5-day dermal exposure or during the 5 days
after a 4-hour dermal exposure was small (approximately
30% of the dose during the 5-day exposure and 1 to
2% after the 4-hour exposure) (129446). Approximately
5 times as much radioactivity was excreted in the
feces as was recovered from the urine, and there was
no significant differences with respect to the formulation
during the 5-day exposure. Animals treated with the
20% dust formulation showed an absorption rate which
was approximately twice that for the 75% Wettable
Powder after the 4-hour exposure.
34
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Presently, the Agency does not know of a definitive
test protocol to study dermal absorption of the PCNB
contaminant, HCB. The Agency also has no basis for
estimating the absorption rates of HCB.
7. Immunotoxicity
Hamsters were given a single dose of 6 gm/kg PCNB by
gavage to evaluate the effect of PCNB on cellular
and humoral immunity (Dandliker et al., 1980). The
fungicide was found to stimulate cellular immunity
and reduce the amount of antibody produced in response
to an immunogen. The binding affinity of antibody to
antigen was observed to increase two- to five-fold in
PCNB treated hamsters when they were compared with
untreated animals. However, the experiments described
by the investigators were not designed to evaluate
the toxicological significance of the immunological
effects of PCNB.
8. Acute Toxicity
PCNB has been classified as Toxicity Category III for
oral and dermal toxicity, and Category IV for inhalation
toxicity, primary eye and dermal irritation. No
data were available for dermal sensitization. Therefore,
a skin sensitization study is required.
The low acute toxicity of PCNB (TOX Categories III &
IV) does not warrant a reentry interval.
9. Environmental Fate Concerns
While the data base is generally inadequate for under-
standing the environmental fate of PCNB, the available
information on leaching do not indicate that PCNB is
likely to contaminate ground water. Preliminary
data indicate that peanuts may bear detectable residues
of PCNB when planted in- rotation with a broadcast
application made eight months earlier- An interim
prohibition against rotating root crops for 12 months
after broadcast and banding applications is appropriate.
We have no basis at this time to prohibit the rotation
of non-root crops following broadcast treatment or
root crops following either seed or transplant treatment
with PCNB. If significant residues are found in
crops planted more than one year after application,
a tolerance may be required for all such crops.
35
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10 . Ecological Effects
Limited data on PCNB indicate that it is toxic to
certain fish species (LC50 = 0.88 ppm for bluegill,
0.50 ppm for rainbow trout, in formulated product
tests) and to aquatic invertebrates (daphnid LC$Q = 0.77
ppm). Toxicity to terrestrial organisms is low (mallard
duck and bobwhite quail LC5Q values > 5000 ppm; rat
acute oral LD5Q approximately 2 g/kg). However,
the potential for chronic effects on avian species
resulting from certain use patterns for PCNB cannot
be assessed without additional data. Since this
compound is toxic to aquatic organisms in laboratory
studies, label precautions are required to alert the
user to the potential for adverse effects on aquatic
organisms.
Assessment of hazard to endangered species will be
deferred pending review of the required data.
D. Tolerance Reassessment
A tolerance has been established at 0.1 ppm for residues
of PCNB in or on cottonseed in 40 CFR §180.291. In addition,
the following interim tolerances for PCNB are established
in 40 CFR §180.319: 1 ppm in or on peanuts and 0.1 ppm in
or on bananas, beans, broccoli, brussels sprouts, cabbage.
cauliflower, garlic, peppers, potatoes, and tomatoes.
(See Table 4).
A two-year feeding study with dogs govern diets containing
0, 30, 180, or 1080 ppm (114201) indicated that PCNB (1.4% HCB)
caused liver weight increases, increased liver-to-body weight
ratios, elevated serum alkaline phosphatase levels, and
microscopically observed cholestatic hepatosis with secondary
bile nephrosis at 1080 ppm (the highest dose tested). The
cholestatic changes were observed in all animals given diets
containing 180 and 1080 ppm PCNB, and one of three males in the
30 ppm dose group exhibited the micorscopic changes (no female
dogs were affected). The authors noted that these histopathologic
changes were moderate in the 1080 ppm group and minimal in the
180 ppm group. Based on these results, 30 ppm was the NOEL and
180 p3m was the LOEL in dogs.
The dog was determined to be the most sensitive species for PCNB.
The NOEL for this study is 30 ppm which is the lowest NOEL
used for calculating a Provisional Acceptable Daily Intake
(PADI).
Because of the absence of a chronic feeding study in rats and
teratology studies in two species a provisional ADI (PADI)
is established. Based on the -NOEL of the dog study, 30
ppm (0.75 mg/kg/day), and applying a 1000 fold safety
factor provides a PADI of 0.00075 mg/kg/day. The Maximum
36
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Permissible Daily Intake (MPI).for a 60 kg person is
0.045 mg/day. Table 5 summarizes the Theoretical Maximum
Residue Contribution (TMRC) for each of the published
tolerances. The resulting percent of the PADI represented
by the TMRC is 55.3.
Table 4. Approved Tolerances for PCNB in or on Agricultural
Commodities
U.S. Mexipan Mexican Canadian Codex
Tolerance Tolerance Processed Tolerance Alimentarius
Crop (ppm) (ppm) Food (ppm)
Cottonseed 0.1 0.1 N/A N/A N/A
Peanuts 1.0 0.1 N/A N/A N/A
Bananas 0.1 N/A N/A N/A N/A
Beans 0.1 0.1 N/A N/A N/A
Broccoli 0.1 0.1 N/A N/A N/A
Brussels 0.1 N/A N/A N/A N/A
sprouts
Cabbage 0.1 0.1 N/A N/A N/A
Cauliflower 0.1 N/A N/A N/A N/A
Garlic 0.1 0.1 N/A N/A N/A
Peppers 0.1 0.1 N/A N/A N/A
Potatoes 0.1 0.1 N/A N/A N/A
Tomatoes 0.1 0.1 N/A N/A N/A
N/A = Not established
37
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Table 5.
Theoretical Maximum Residue Contribution of
Approved Tolerances for PCNB in or on
Raw Agricultural Comodities (CFR §180.291 and
Crop
Cottonseed
Peanuts
Bananas
Beans
Broccoli
Brussels sprouts
Cabbage
Cauliflower
Garlic
Peppers
Potatoes
Tomatoes
Tolerance
(ppm)
0.1
1.0
0.1
0,
0,
0,
0
0
0.1
0.1
0.1
0.1
Food
Factor*
0.15
0.36
1.42
2.04
0.10
0.03
0.74
0.07
0.03
0.12
5.43
2.87
ing/day
(1.5 kg
319)
diet)**
0.00022
0.00537
0.00213
0.00306
0.00015
0.00005
0.00110
0.00011
0.00015
0.00018
0.00314
0.00431
TMRC = 0.02487 mg/day
*The food factor is the percentage of a 1.5 kg daily
diet represented by a given crop.
**mg/day = 1.5 kg diet X food factor X tolerance (ppm).
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IV. REGULATORY POSITION AND RATIONALE.
i
A. Regulatory Positions
Based on the review and evaluation of available data and
other relevant information on Pentachloronitrobenzene (PCNB),
the Agency has made the following determinations:
1. Special Review
The Agency will not place PCNB and its major contaminant,
hexachlorobenzene (HCB) into Special Review at this time
[40 CFR, Section 154 . 7{a)(2)] .
Rationale; PCNB was previously placed in Special Review by
the Agency in October 1977, because of its oncogenic potential
in mice. The Agency subsequently included HCB in its
consideration of the pesticide's oncogenic potential.
Although the data base is inadequate to completely
assess the oncogenic potential of PCNB, the Agency
has concluded that the oncogenic effects associated
with commercially produced PCNB are likely to be due
to the presence of its contaminant, hexachlorobenzene
(HCB). PCNB has been classified as a Group D carcinogen
(inadequate evidence of carcinogenicity in animals).
HCR has been classified as a Group 82 carcinogen (probable
human carcinogen). /The registrants of PCNB agreed to
reduce the HCB levels in technical PCNB as a condition
of continued registration. Thus, if the level of HCB
contamination were reduced in commercially produced
PCNB, the risk associated with exposure to PCN-B would
also be reduced.
At the reduced HCB contamination levels, PCNB does not
meet any of the criteria for intiation of a Special Review
at this time. The risk estimates for PCNB, with 0.1%
HCB contaminant level, for applicators ranged from
10~5 to 10~6 and were based on 100% dermal absorption
(in the absence of data). Additional data are required
to completely assess the oncogenic potential of PCNB.
Upon receipt and review of these data, the Agency will
determine if additional regulatory action is needed.
2. Compliance with the Conditions in Notice of Determination
of April 28, 1982
Registrants are required to comply with the conditions
agreed to and published in the Notice of Determination
Concluding the Rebuttable Presumption Against Registration
of April 28, 1982.
39
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Rationale; Presented below are the risk reduction
measures the PCNB registrants agreed to adopt. These
measures were conditions to the continued registration of
PCNB products. These measures collectively will minimize
exposure to PCNB and HCB while additional data to completely
assess the risk associated with the continued use of PCNB
are generated.
a. Required for Manufacturing-Use Products
(1). Implement new technology to lower the HCB level in PCNB
to 0.1 percent or less by April, 1988.
(2). Complete a residue study of PCNB and HCB levels in
potatoes after processing to determine if PCNB and HCB
levels concentrate in processed foods and whether a
tolerance is needed under Section 409 of FFDCA.
The study was submitted and found to be inadequate by the
Agency. Therefore, the study must be repeated and submitted to
the Agency by January 1989.
b. Required for End-Use Products
(1). Amend labels on granular formulations registered for
use in parks and on golf courses to minimize contamination
of potable water supplies.
(2). Amend labels on homeowner products to include
a warning to avoid contact with skin by wearing protective
clothing and recommending washing hands after using the
product to minimize the user's exposure to PCNB.
(3). Amend labels for professional applicator products
to include protective clothing and respirator requirements
to minimize the user's exposure to PCNB during mixing/loading
procedures.
3. Interim Tolerances
The Agency does not at this time intend to establish new
food additive regulations for PCNB pursuant to Section 409
of the Federal, Food, Drug, and Cosmetic Act [FFDCA]. It
will defer action on established food additive regulations
until receipt and evaluation of residue data.
Rationale; Section 409 of the FFDCA bars the establishment
of food additive regulations for substances which induce
cancer in man or test animals. HCB, a contaminant of PCNB
induces oncogenic responses in test animals.
40
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4. Rotational Crop Restrictions
The-Agency has determined that in order to remain in
compliance with FIFRA, registrants must relabel their products
to impose a 12 month restriction on root crops which are
planted on a rotational basis. The extent of the restrictions
will be reconsidered when additional data are submitted and
reviewed.
Rationale; Preliminary data indicate that peanuts may bear
detectable residues of PCNB if planted in rotation where a
broadcast application was made eight months earlier. An interim
prohibition against rotating root crops for 12 months after
broadcast and banding applications will serve to protect the
public from impermissable residues in root crops. There are
no data available at this time to prohibit the rotation of
non-root crops following broadcast treatment or root crops
following either seed or transplant treatment with PCNB.
Data on rotational crops are required in this standard.
5. Non-Target Organisms
The Agency has determined that in order to remain in compliance
with FIFRA, registrants must relabel their products to
include precautions for hazards to fish and other aquatic
organisms in order to prevent unreasonable adverse effects
on the environment. These label requirements are specified
in Section D of this Part.
Rationale; PCNB is toxic to aquatic organisms in laboratory
studies. Label precautions are provided to alert the user
to the potential for adverse effects on aquatic organisms.
6. Reentry/Clothing Requirements
The Agency has determined that re-entry intervals or
protective clothing requirements for non-applicators are
not necessary.
Rationale: The toxicity of this compound does not warrant
concern about exposure of non-applicators, such as workers
re-entering a treated field, according to the criteria of
40 CFR Part 158.140. PCNB is in Toxicity Category
III for acute effects, and no chronic health concerns
of significance have been identified. In addition,
the Agency has concluded that the exposure likely to
result from the registered uses of this pesticide at
recommended label rates would not pose significant
risks of dermal or ocular irritation or sensitization
effects for agricultural workers or other persons not
applying or handling concentrated formulations of
these pesticides, because of the degree of dilution
involved in applied formulations.
41
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7. New Uses
The Agency will not register any significant new uses
for ,PCNB products until the chronic feeding and oncogenicity
studies required in the Registration Standard are submitted
and reviewed.
Rationale: The Agency has decided to allow the continued
registrations of currently registered PCNB products but
not register any additional significant new uses of PCNB
until the chronic data base is complete.
8. FIFRA Requirements
While the data gaps are being filled, currently registered
MPs and EPs containing PCNB as the sole active ingredient
may be sold, distributed, formulated and used in the
United States, subject to the terms and conditions
specified in this Standard. Registrants must provide
and agree to develop additional data, as specified in
the Data Appendices of this guidance document, in order
to maintain existing registrations.
Rationale: Under FIFRA, the Agency may elect not to
cancel or withhold registration simply because data
are missing or inadequate (see FIFRA sec. 3(c)(2)(B)
and 3(c)(7)). Issuance of this Standard provides a
mechanism for identifying data needs. These data will
be evaluated, after which the Agency will determine
if additional regulatory changes are necessary.
42
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B. Criteria For Registration Under This Document
To be registered or reregistered under this Standard, products must
contain PCNB as the sole active ingredient, bear required labeling,
and conform to the product composition, acute toxicity limits, and
use pattern requirements listed in this section.
C. Acceptable Ranges And Limits
1. Product Composition Standard
To be registered or reregistered under this Standard, manufacturing-
use products (MPs) must contain PCNB as the sole active ingredient and
HCB at a level <_ 0.1% by April, 1988. Each MP- formulation proposed
for registration must be fully described with an appropriate
certification of limits, sta.fcing maximum and minimum amounts of
the active ingredient and inert ingredients which are present in
products, as well as impurities found at greater than 0.1%.
2. Acute Toxicity Limits
The Agency will consider registration of technical grade and manu-
facturing-use products containing PCNB provided that the product
labeling bears appropriate precautionary statements for the acute
toxicity category in which each product is placed.
3. Use Patterns
To be registered under this Standard, manufacturing-use
products must be labeled for formulation into end-use products
only for the commodities listed below. The EPA Index to
Pesticide Chemicals lists all registered uses, as well as
approved maximum application rates and frequencies.
-Terrestrial, non-domestic, food uses on: field crops,
vegetable crops, and seed treatments;
-Terrestrial, non-domestic, non-food uses on: ornamentals
including rose bushes and turf.
43
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D. Required Labeling
To be registered under this standard, all manufacturing-use and
end-use PCNB products must bear appropriate labeling as specified
in 40 CFR 162.10, and below. Appendix II contains information on
label requirements.
Pesticide products containing PCNB released for shipment by a
registrant or producer of that product after January 30, 1988, are
required to bear an amended label which complies with the require-
ments of this Standard.
Pesticide products containing PCNB which are distributed, sold,
offered for sale, held for sale, shipped, delivered for shipment,
or received and (having been so received) delivered or offered to
be delivered by any person after January 30, 1989, are required to
bear an amended label which complies with the requirements of this
Standard.
The following information must appear on the labeling within the
time limits specified above:
1. Ingredient Statement
The ingredient statement for all MPs and EPs must list the active
ingredient in the following manner:
Pentachloronitrobenzene (PCNB) % •
2. Use Pattern Statements
All manufacturing-use products containing PCNB must state that
they are intended for formulation into end-use products for only
the aforementioned use patterns. Labeling must specify sites
for each registered use pattern. However, no use may be included
on the label if the registrant fails to comply with the data
requirements for that use pattern, as listed in Table A of the Data
Appendices of this document.
44
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2. Precautionary Statements
a. jlanufacturing-use Product Statements
All PCNB products intended for formulation into end-use
products must bear the following statements:
"This pesticide is toxic to fish and aquatic organisms. Do
not discharge effluent containing this product into lakes,
streams, ponds, estuaries, oceans, or public water unless
this product is specifically identified and addressed in an
NPDES permit. Do not discharge effluent containing this
product into sewer systems without previously notifying the
sewage treatment'plant authority. For guidance, contact
your State Water Board or Regional Office of the EPA."
b. End-use Product Statements
1) The precautionary statements must appear on the fol-
lowing EP labels:
0 Amend labels for granular formulations used in parks and
on golf courses to include the following precautionary
statement:
"Do not apply directly adjacent to potable water
supplies."
0 Amend labels for homeowner products to include the
following precautionary statement:
"Avoid contact with skin by wearing the following pro-
tective clothing: wear gloves, long-sleeved shirt, long
pants, socks and shoes. Wash hands thoroughly after
using."
0 Amend labels for professional applicator products to
include the following protective clothing requirements
during mixing/loading procedures:
"Granular formulations; wear gloves, long-sleeved shirt,
long pants, socks and shoes";
"Emulsifiable concentrate and liquid formulations:
wear respirator,gloves,long-sleeved shirt,long pants,
socks and shoes";
"Dust based formulations used as a planter box seed-
treatment; wear dust mask, gloves, long-sleeved shirt,
long pants, socks and shoes."
45
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2) The following environmental precautionary statements
must appear on all Non-seed Treatment and Non-granular
EP labels for Outdoor Uses:
"This pesticide is toxic to fish and aquatic organisms.
Drift and runoff from treated areas may be hazardous to
fish and aquatic organisms in adjacent aquatic sites.
Do not apply directly to water or wetlands (swamps,
bogs, marshes, and potholes). Do not contaminate
water or wetlands by cleaning of equipment or disposal
of wastes."
3) The following environmental precautionary statements
must appe.ar on all Seed Treatment or Granular EP labels
for Outdoor uses:
"This pesticide is toxic to fish and aquatic organisms.
Cover or incorporate treated seeds (granules). Do not
contaminate water or wetlands by cleaning of equipment
or disposal of wastes."
4) The following restriction on rotational crops must
appear on the label of all EPs:
"Do not plant root crops in PCNB treated fields within
12 months of broadcast and banding applications unless
PCNB is registered for use on those crops."
46
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V. PRODUCTS SUBJECT TO THIS STANDARD
All products containing one or more o-f the pesticides
identified in Section II.A. are subject to certain requirements
for data submission or changes in composition, labeling or
packaging of the product. The applicable requirements depend
on whether the product is a tianufacturlng or end use product
and whether the pesticide is the sole active Ingredient or
one of multiple active ingredients.
Products are subject to this Registration Standard as
follows:
A. Manufacturing use products containing this pesticide as
the sole active Ingredient are subject to:
1. The restrictions (if any) upon use, composition, or
packaging listed in Section IV, if they pertain to the
manufacturing use product.
2. The data requirements listed in Tables A and B2
3. The labeling requirements speciriea 1'or manufacturing
use products in Section IV.
4. Administrative requirements (application forms, Confiden-
tial Statement of Formula, data compensation provisions)
associated with rereglstration.
2 Data requirements are listed in the three Tables in
Appeudix I of this Registration Standard. The Guide to
Tables in that Appendix explains how to read the Tables.
Table A lists generic data requirements applicable to all
products containing the pesticide subject to this Registra-
tion Standard. Table B lists product-specific data applicable
to manufacturing use products. The data in Tables A and B
need not be submitted by a producer who Is eligible for the
formulator's exemption for that active Ingredient.
Table C lists product-specific data applicable to end use
products. The Agency has decided that, in most cases, it
will not require the submission of product-specific data for
end use products at this time. Therefore most Registration
Standards do not contain a Table C.
47
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B. Manufacturing use products containing this pesticide
as oi.e of- multiple active ingredients are subject to:
The data requirements listed in Table A.
C. End use .products containing this pesticide as the
sole active ingredient are subject to:
1. The restrictions (if any) upon use, composition, or
packaging listed in Section IV if they pertain to the
end use product.
2. If eligible for the formulator's exemption3, the
data requirements listed in Table C.
3. If not eligible for the formulator's exemption, the
data requirements listed in Table A and the data require-
ments listed in Table C.
4. The labeling requirements specified for end use
products in Section IV.
D. End use products containing this pesticide as one of
multiple active ingredients are subject to:
a. If not eligible for the formulator's exemption,
the date requirements listed in Tables A and C.
b. If eligible for the formulator's exemption, the
data requirements listed in Table C.
3 If you purchase from another producer and use as the
source of your active ingredient only EPA-registered products,
you are eligible for the formulator's exemption for generic
data concerning that active ingredient (Table A) and product-
specific data for the registered manufacturing use product
you purchase (Table B).
Two circumstances nullify this exemption:
1) If you change sources of active ingredient to an
unregistered product, formulate your own active ingredient,
or acquire your active ingredient from a firm with ownership
in common with yours, you individually lose the exemption
and become subject to the data requirements in Table A.
2) If no producer subject to the generic data requirements
in Table A agrees to submit the required data, all end use
producers lose the exemption, and become subject to those
data requirements.
48
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VI. REQUIREMENT FOR SUBMISSION OF GENERIC DATA
This portion of the Registration Standard is a notice
issued under the authority of PIFRA sec. 3(c)(2)(B). It
refers to the data listed in Table A, which are required to
be submitted by registrants to maintain in effect the regis-
tration of products containing this active ingredient.4
A. What are generic data?
Generic data pertain to the properties or effects of a
particular active ingredient. Such data are relevant to an
evaluation of all products containing that active ingredient
regardless of whether the product contains other ingredients.
(unless the product bears labeling that would make the data
requirement inapplicable).
Generic data may also be data on a "typical formulation"
of a product. "Typical formulation" testing is often required
for ecological effects studies and applies to all products
having that formulation type. These are classed as generic
data, and are contained in Table A.
B. Who must submit generic data?
All current registrants are responsible for submitting
generic data in response to a data request under PIPRA sec.
3(c)(2).(B) (DCI Notice). EPA has decided, however, not to
require a registrant who qualifies for the formulator's
exemption (FIPRA sec. 3(c)(2)(D) and § 152.85) to submit
generic data in response to a DCI notice if the registrant
who supplies the active ingredient in his product is complying
with the data request.
If you are not now eligible for a formulator's exemption,
you may qualify for one if you change your source of supply
to a registered source that does not share ownership in
common with your firm. If you choose to change sources of
supply, the Confidential Statement of Formula must identify
the new source(s) and you must submit a Formulator's Exemption
Statement form.
If you apply for a new registration for products containing
this active ingredient after the issuance of this Registration
Standard, you will be required to submit or cite generic
data relevant to the uses of your product if, at the time
** Registrations granted after issuance of this Standard
will be conditioned upon submission or citation of the data
listed in this Registration Standard.
49
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the application is submitted, the data have been submitted
to the Agency by current registrants. If the required jata
have not yet been submitted, any new registration will be
conditioned upon the new registrant's submission or citation
of the required data not later than the date upon which
current registrants of similar products are required to provide
such data. See PIFRA'sec. 3(c)(7)(A). If you thereafter fail
to comply with the condition of that registration to provide
data, the registration may be cancelled (PIPRA sec. 6(e)).
C. What generic data must be submitted?
You may determine which generic data you must submit by
consulting Table A. That table lists the generic data needed
to evaluate current uses of all products containing this
active Ingredient, the uses for which such data are required,
and the dates by which the data must be submitted to the
Agency.
D. How to comply with PCI requirements.
Within 90 days of your receipt of this Registration
Standard, you must submit to EPA a completed copy of the form
entitled "PIPRA Section 3(c)(2)(B) Summary Sheet" (EPA Form
8580-1, enclosed) for each of your products. On that form
you must state which of the following six methods you will
use to comply with the DCI requirements:
1. You will submit the data yourself.
2. You have entered into an agreement with one or more
registrants to Jointly develop (or share in the cost of
developing) the data, but will not be submitting the data
yourself. If you use this method, you must state who will
submit the iata on which you will rely. You must also provide
EPA with documentary evidence that an agreement has been
formed which allows you to rely upon the data to be submitted.
Such evidence may be: (1) your letter offering to Join in
an agreement and the other registrant's acceptance of your
offer, (2) a written statement by the parties that an agreement
exists, or (3) a written statement by the person who will be
submitting the data that you may rely upon its submission.
The Agency will also require adequate .assurance that the
person whom you state will provide the data is taking appropriate
steps to secure it. The agreement to produce the data need
not specify all of the terms of the final arrangement between
the parties or a mechanism to resolve the terms.
50
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3- -You have attempted to enter into an agreement to
Jointly develop data, but no other registrant has accepted
your offer. You request that EPA not suspend your registration
for non-compliance with the PCI. EPA has determined that,
as a general policy, it will not suspend the registration of
a product when the registrant has in good faith sought and
continues to seek to enter into a data development/cost
sharing program, but the other registrants developing the
data have refused to accept its offer. [If your offer is
accepted, you may qualify for Option 2 above by entering
intc an agreement to supply the data.]
In order to qualify for this method, you must:
1. Pile with EPA a completed "Certification of Attempt
to Enter into an Agreement with other Registrants for Develop-
ment of Data" (EPA Form 8580-6, enclosed).
2. Provide us with a copy of your offer to the other
registrant and proof of the other registrant's receipt of your
offer (such as a certified mail receipt). Your offer must,
at a minimum, contain the following language or its equivalent:
[Your company name] offers to share in the burden of
producing the data required pursuant to PIFRA sec.
3(c)(2)(B) in the [name of active ingredient] Registration
Standard upon terms to be agreed or failing agreement
to be bound by binding arbitration as provided by FIFRA
section 3(c)(2)(B)(iii).
The remainder of your offer may not in any way attempt to
limit this commitment. If the other registrant to whojn your
offer is made does not accept your offer, and if the o'ther
registrant informs us on a DCI Summary Sheet that he will
develop and submit the data required under the DCI, then you
may qualify for this option. In order for you to avoid
suspension under this method, you may not later withdraw or
limi* your offer to share in the burden of developing the
data. In addition, the other registrant must fulfill its
commitment to develop and submit the data.
**• You request a waiver of the data requirement. If
you believe that a data requirement does not (or should not)
apply to your product or its uses, you must provide EPA with
a statement of the reasons why you believe this is so. Your
statement must address the specific composition or use factors
that lead you to believe that a requirement does not apply.
Since the Agency has carefully considered the composition and
uses of pesticide products in determining that a data require-
ment applies, EPA does not anticipate that many waivers will
be granted. A request for waiver does not extend the time-
frames for developing required data-, and if your waiver
request is denied, your registration may be suspended if you
fail to submit the data.
51
-------
5- -You request that EPA amend your registration by deleting
the uses for which the data are needed. You are not required
to submit 3ata For uses which are no longer on your label.
6. You request voluntary cancellation of the registration
of your product(s) for which the data are needed
E. Procedures for requesting a change in testing protocol.
If you will generate the require! data and plan to use
test procedures which deviate from (or are not specified in)
either EPA's Pesticide Assessment Guidelines or the Reports
of Expert Groups to the Chemicals Group, Organization for
Economic Cooperation and Development (OECD) Chemicals Testing
Programme, you must submit for SPA approval the protocols
you propose to use.
You should submit your protocols before beginning testing
and c.wait EPA approval, because the Agency will not ordinarily
accept as sufficient studies using unapproved protocols.
A request for protocol approval will not extend the timeframe
for submission of the data, nor will extensions generally be
given to conduct studies due to submittal of inappropriate
protocols.
P. Procedures for requesting extensions of time.
If you think that you will need more time to generate
the data than is allowed by EPA's schedule, you may submit a
request for an extension of time. Any request for a time
extension which is made as an initial response to a section
3(c)(2)(B) request notice must be submitted in writing to
the Product Manager listed at the end of this section and .
must be made before the deadline for response. Once dates
have been committed to and EPA has accepted these commitments,
any subsequent requests for a -time extension must be submitted
in writing to the Office of Compliance Monitoring.
EPA will view failure to request an extension before
the response deadline as a waiver of any future claim that
there was insufficient time to submit the data. While EPA
considers your request, you must strive to meet the deadline
for submitting the data.
The extension request should state the reasons why you
believe that an extension is necessary and the steps you
have taken to meet the testing deadline. Time extensions
normally will not be granted due to ^problems with laboratory
capacity or adequacy of funding, since the Agency believes
that with proper planning these can be overcome. Time extensions
may be considered when Joint data development is planned,
52
-------
or when the Agency must approve a new or modified protocol
before the study can be begun.
A-request for an extension does not extend the tlmeframe
for submission of the data. If EPA denies your request for
a time extension and you do not submit the data as request?1,
EPA may begin proceedings to suspend the registrations of
your products.
3. Existing stocks provision upon suspension or cancellation.
The Agency has determined that if a registration is
suspended for failure to respond to a DCI request under
FIFRA sec. 3(c)(2)(B), an existing stocks provision is not
consistent with the Act. Accordingly, the Agency does not
anticipate granting permission to sell or -distribute existing
stocks of suspended product except in rare circumstances.
If you believe that your product will be suspended or cancelled
and that an existing stocks provision should be granted, you
have the burden of clearly demonstrating to EPA that granting
such permission would be consistent with the Act. The following
information must be included in any request for an existing
stocks provision:
1. Explanation of why an existing stocks provision is
necessary, including a statement of the quantity of
existing stocks and your estimate of the time required
for their sale or distribution; and
2. Demonstration that such a provision would be consis-
tent with the provisions of FIFRA.
53
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VII. REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA
Under its DCI authority, EPA has determined that certain
product-specific data are required to maintain your registrations
in effect. Product-specific data are derived from testing
using a specific formulated product, and, unlike generic
data, generally support only the registration of that product.
All such data must be submitted by the dates specified in
this Registration Standard.
If you have a manufacturing use product, these data are
listed in Table B. If you have an end use product, the data
are listed in Table C. As noted earlier, the Agency has
decided that it will not routinely require product-specific
data for end use products at this time. Therefore, Table C
may not be contained in this Registration Standard; if there
is no Table C, you are not required to submit the data at
this time.
In order to comply with the product specific data require-
ments, you must follow the same procedures as for generic data.
See Section VI.D, E, F, and G. You should note, however, that
product chemistry data are required for every product, and the
only acceptable responses are options VI.D.I. (submit data)
or VI.D.6.(cancellation of registration).
Failure to comply with the product-specific data require-
ments for your products will result in suspension of the
product's registration.
54
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VII'I. ~ REQUIREMENT FOR SUBMISSION OF REVISED LABELING
FIFRA requires each product to be labeled with accurate,
complete and sufficient instructions and precautions, reflecting
the Agency's assessment of the data supporting the product
and its uses. General labeling requirements are set out in
40 CFR 162.10 (see Appendix II - LABELING and SUMMARY). In
addition, labeling requirements specific to products containing
this pesticide are specified in Section VI.D of this Registra-
tion Standard. Applications submitted in response to this
notice must include draft labeling for Agency review.
If you fail to submit revised labeling as required,
which complies with 40 CFR 162.10 and the specific instructions
in Section VI.D., EPA may seek to cancel or suspend the
registration of your product under FIFRA sec. 6.
55
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IX. INSTRUCTIONS FOR SUBMISSION
A. Manufacturing Use Products (MUPs) containing PCNB
as sole active ingredient.
1. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division
for each product subject to this Registration Standard:
a. The "FIFRA Section 3(c)(2)(B) Summary Sheet" (EPA
Form 8580-1), with appropriate attachments.5
b. Confidential Statement of Formula (EPA Form 8570-4).
c. Formulator's Exemption Statement (EPA Form 8570-27),
if applicable.
d. Evidence of compliance with data compensation
requirements of FIFRA sec. 3(c)(l)(D). Refer to 40 CFR
152.80-152.99.
2. Within 9 months from receipt of this document you
must submit to the Product Manager:
a. Application for Pesticide Registration (EPA
Form 8570-1).
b. Two copies of any required product-specific data
(See Table B).
c. Three copies of draft labeling, including -the
container label and any associated supplemental labeling.
Labeling should be either typewritten text on 8-1/2 x 11
inch paper or a mockup of the labeling suitable for
storage in 8-1/2 x 11 files. The draft label must indicate
the intended colors of the final label, clear indication
of the front panel of the label, and the intended type
sizes of the text.
d. Product Specific Data Report (EPA Form 8580-4).
5 If on the Summary Sheet, you commit to develop the data,
present arguments that a data requirement is not applicable
or should be waived, or submit protocols or modified protocols
for Agency review, you must submit a copy of the Summary
Sheet (and any supporting information) to the Office of
Compliance Monitoring, which will be monitoring the data
generated in response to this notice. This submission is in
addition to responding to the Product Manager, and should be
submitted to the Office of Compliance Monitoring at the
address given at the end of this section. (Actual studies
are not to be submitted to the Office of Compliance Monitoring
56
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3. Within the times set forth in Table A, you must
submit to the Registration Division all generic data, unless
you are eligible for the formulator's exemption. If for any
reason any test is delayed or aborted so that the schedule
cannot be met, immediately notify the Product Manager and
the Office of Compliance Monitoring of the problem, the
reasons for the problem, and your proposed course of action.
B. Manufacturing Use Products containing PCNB
in combination with other active ingredients.
1. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division:
a. FIFRA sec. 3(c)(2)(B) Summary Sheet, with appropriate
attachments5 (EPA Form 8580-1).
b. Confidential Statement of; Formula (EPA Form 8570-4)
c. Formulator's Exemption Statement (EPA Form 8570-27),
if applicable.
2. Within the time frames set forth in Table A, you must
submit to the Registration Division all generic data, unless
you are eligible for the formulator's exemption. If for any
reason any test is delayed or aborted so that the schedule
cannot be met, immediately notify the Product Manager and
the Office of Compliance Monitoring of the problem, the
reasons for the problem, and your proposed course of action.
C. End Use Products containing PCNB as sole active ingredient.
1. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division:
a. FIFRA Section 3(c)(2)(B) Summary Sheet, with
appropriate attachments5 (EPA Form 8580-1).
b. Confidential Statement of Formula (EPA Form 8570-4).
c. Formulator's Exemption Statement (EPA Form 8570-27),
if applicable.
2. Within 9 months from receipt of this document you
must submit to the Product Manager:
a. Two copies of any product-specific data, if required
by Table C.
b. Product Specific Data Report (EPA Form 8580-4),
if Table C lists required product-specific data.
57
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c. Three copies of draft labeling, including the container
label and any associated supplemental labeling. Labeling should
be either typewritten text on 8-1/2 x 11 inch paper or a mockup
of the labeling suitable for storage in 8-1/2 x 11 files. The
draft labeling must indicate the intended colors of the final
label, clear indication of the front panel of the label, and
the intended type sizes of the text. End use product labeling
must comply specifically with the instructions in Section IV
(Regulatory Position and Rationale).
D. Intrastate Products containing PCNB either as sole active
ingredient or in combination with other active ingredients.
These products are being called in for full Federal regis-
tration. Producers of these products are being sent a letter
instructing them how to submit an application for registration.
E. Addresses
The required information must be submitted to-the following
address:
Lois Rossi, Product Manager 21
Registration Division (TS-767C)
Office of Pesticide Programs
Environmental Protection Agency
401 M St., SW
Washington, D.C. 20460
The address for submissions to the Office of Compliance
Monitoring is:
Laboratory Data Integrity Program
Office of Compliance Monitoring (EN-342)
Environmental Protection Agency
401 M St., SW
Washington, D.C. 20460.
58
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TGUIDR-1
GUIDE TO TABLES
Tables A, B, and C contain listings of data requirements
for the pesticides covered by this Registration Standard.
Table A contains generic data requirements that apply to
the pesticide in all products, including data requirements
for which a "typical formulation" is the test substance.
Table B contains product-specific data requirements that
apply only to a manufacturing use product.
Table C contains product-specific data requirements that
apply only to an end use product.
The data tables are generally organized according to the
following format:
1. Data Requirement (Column 1). The data requirements are
listed in the order in which they appear in 40 CFR Part 158.
The reference numbers accompanying each test refer to the
test protocols set out in the Pesticide Assessment Guidelines,
which are available from the National Technical Information
Service, 5285 Port Royal Road, Springfield, VA 22161.
2. Test Substance (Column 2). This column lists the composition
of the test substance required to be used for the test, as
follows:
TGAI = Technical grade of the active ingredient, PCNB, contain-
ing a HCB contaminant level of 0.07 percent.
PAI = Pure active ingredient
PAIRA = Pure active ingredient, radio labeled
TEP = Typical end use formulation
MP = Manufacturing use product
EP = End use product
Any other test substances, such as metabolites, will be
specifically named in Column 2 or in footnotes to the table.
3. Use pattern (Column 3). This column indicates the use
patterns to which the data requirement applies. Use patterns
are the same as those given in 40 CFR Part 158. The following
letter designations are used for the given use patterns:
A = Terrestrial, food
B = Terrestrial, non-food
C = Aquatic, food
n = Aquatic, non-food
R = Greenhouse, food
F = Greenhouse, non-food
G = Forestry'
H = Domestic outdoor
I = Indoor
Any other designations will be defined in a footnote to the table.
59
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TGUIDE-2
4. Does EPA have data? (Column 4). This column indicates one
of three answers:
YES - EPA has data in its files that completely satisfy
this data requirement. These data may be cited by
other registrants in accordance with data compensation
requirements of Part 152, Subpart E.
PARTIALLY - EPA has some, data in its files, but such data
do not fully satisfy the' data requirement. In some cases,
the Agency may possess data on one of two required species,
or may possess data on one test substance but not all.
The term may also indicate that the data available to
EPA are incomplete. In this case, when the data are
clarified, or additional details of the testing submitted
by the original data submitter, the data may be determined
to be acceptable. If this is the case, a footnote to
the table will usually say so.
NO - EPA either possesses no data which are sufficient
to fulfill the data requirement, or the data which EPA
does possess are flawed scientifically in a manner that
cannot be remedied by clarification or additional infor-
mation.
5. Bibliographic citation (Column 5). If the Agency has
acceptable data in its files, this column lists the identifying
number of each study. This normally is the Master Record
Identification (MRID) number, but may be a GS number if no
MRID number has been assigned. Refer to the Bibliography'
Appendices for a complete citation of the study.
6. Must additional data be submitted? (Column 6). This
column indicates whether the data- must be submitted to the
Agency. If column 3 indicates that the Agency already has
data, this column will usually indicate NO. If column 3
indicates that the Agency has only partial data or no data,
this column will usually indicate YES. In some cases, even
though the Agency does not have the data, EPA will not require
its submission because of the unique characteristics of the
chemical; because data on another chemical can be used to
fulfill the data requirement; or because the data requirement
has been waived or reserved. Any such unusual situations
will be explained in a footnote to ^he table.
7. Timeframe for submission (Column 7). if column 5 requires
that data be submitted, this column indicates when the data
are to be submitted, based on the issuance date of the Regis-
tration Standard. The timeframes are those established either
as a result of a previous Data Call-In letter, or standardized
timeframes established by PR Notice 85-5 (August 22, 1985).
8. Footnotes (at the end of each table). Self-explanatory.
60
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GENERIC DATA REQUIREMENTS FOR PTNB:
TARLR A
[97% TECHNICAL, RPA RRG. NO. 2749r9), 196% TECHNICAL, RPA REG. NO. 10H20-U
(96% TECHNICAL, RPA REG. NO. 400-401], f95% TECHNICAL, RPA REG. NO. 5481-197]
[94% TECHNICAL, RPA REG. NO. 524-1221
Data Requirement Test I/
Substance
SI 58. 120 Product Chemistry
Product Identity
61-1 —Product Identity & Dis-
closure of Ingredients
61-2 - Description of Beginning
Materials & Manufacturing
Process
61-3 - Discussion of Formation of
Inpurities
Analysis and Certification of
Product Ingredients
62-1 - Preliminary Analysis of
Product Samples
62-2 - Certification of Ingredjent
Limits
62-3 - Analytical Methods to
Verify Certified Limits
Physical and Chemical
Characterist ics
63-2 - Color
63-3 - Physical State
63-4 - Odor
63-5 - Melting Point
63-6 - Boi.ling Point
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
Use Does EPA Bibliographic Must Additional Time Frame
Patterns Have Data?!/ Citation2./ Data be for
Submitted? Submission
All
All
All
All
All
All
All
All
All
All
All
No
No
No
No
No
No
No
No
No
No
No
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Yes
Yes V
Yes V
Yes
Yes
Yes
Yes
Yes
Yes
Yes
YPS
6 Months
April 1988
April 1988
12 Months
12 Months
12 Months
6 Months
6 Months
6 Months
6 Months
6 Months
61
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TABLE A
GENERIC DATA REQUIREMENTS FOR PCNB: [97% TECHNICAL, EPA REG. NO. 2749-91, f96% TECHNICAL, EPA REG. NO. J0820-1I
(96% TECHNICAL, EPA RKG. NO. 400T401), |95% TECHNICAL, EPA RRC;. NO. 5481-197)
194% TECHNICAL, EPA REG. NO. 524-122]
Data Requirement
Tost Use Does EPA Bibliographic Must Additional Time Frame
Substance Patterns Have Data??/ Citation?/ Data he for
Submitted? Submission
Physical and Chemical Characteristics
(Continued)
63-7 '- Density, Bulk Density, or
Specific Gravity
63-8 - Solubility
63-9 - Vapor Pressure
63-10 - Dissociation constant
63-11 - Octanol/water partition
coefficient
63-12 - pH
63-13 - Stability
Other Requirements;
64-1 - Submittal of samples
TGAI
All
TCAI or PAI All
PAI
PAI
PAI
TCAI
TGAL
TGAI, PAI All
No
All
All
All
All
All
All
No
No
No
No
No
No
N/A
N/A
N/A
N/A
N/A
N/A
N/A
No
Yes
Yes
Yes
Yes
Yes
Yes
Yes
No!/
6 Months
6 Months
6 Months
6 Months
6 Months
6 Months
6 Months
I/ The PCNB test substance to be used as specified for each data requirement must be that substance which is currently
produced and marketed.
2/ Not applicable. Although product chemistry data may have been submitted in the past, the Agency has determined that
these data must be resubmitted for each pesticide. New requirements have been introduced and previously submitted
data must be updated. Therefore bibliographic citations for the old data are not applicable.
3/ In accordance with the agreement between PCNB registrants and the Agency of April 28, 1982, registrants are required
to submit an annual progress report summarizing efforts to implement HCB reduction measures. The registrants must
implement new technology to lower the HCB contaminant level in technical PCNB to 0.1% or less by ApriJ 1988.
4/ The compound does not require submittal of samples at this time.
62
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TABLE A
GENERIC DATA REQUIREMENTS FOR PCNB
— •—•
Date
SI 58,
Requirement
.135 Toxicology
Test Use Does EPA Bibliographic Must Additional Time Frame
Substance Patterns Have Data? Citation Data be for
Submitted Submission
ACUTE TESTING:
81-1
81-2
81-.3
81-4
81-5
81-6
81-7
- Acute Oral Toxicity - Rat
- Acute Dermal Toxicity
- Rabbit
- Acute Inhalation Toxicity
- Rat
- Eye Irritation - Rabbit
- Dermal Irritation - Rabbit
- Dermal Sensitization -
Guinea Pig
- Acute Delayed
Neurotoxicity - Hen
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
A,B Yes 00001555, No
A,B Yes 00001665, 00001668 No
00001870, 00114220
A,B Yes 00114203, No
A,B Yes 00114203, No
A,B Yes 00001668, 00114220 No
00114222
A,B No — Yes 9 Months
A,B No — No \J
SUBCHRONIC TESTING:
82-1
82-2
82-3
- 90-Day Feeding:
- Rodent, and
- Nonrrodent (Dog)
- 21-Day Dermal
- 90-Day Dermal - Rabbit
TGAI
TGAI
TGAI
TGAI
A,B Yes GS 128-003 No
A,B Yes 00114201 No 2/
A,B No ' — No 3/
A,B No — No 3/
63
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TABLE A
GENERIC DATA REQUIREMENTS FOR PCNB
Date Requirement
Test USP Does EPA Bibliographic
Substance Patterns Have Data? Citation
Must Additional Time Frame
Data be for
Submitted Submission
SUBCHRONIC TESTING:
82-4
82-5
- 90-Day Inhalation: TGAI A,B No
- Rat
- 90-Day Neurotoxicity: TGAI A,B No
No V
No I/
Hen/Mammal
CHRONIC TESTING;
83-1 - Chronic Toxicity -
2 species:
- Rodent,
- Non-rodent (Dog)
83-2 - Oncogenicity -
2 species:
- Rat (preferred),
- Mouse (preferred)
83-3 - Teratogenicity -
2 species:
83-4 - Reproduction - Rat
2-generation
TGAI lO/
TGAI
TGAT 10/
TGAI
A,B
A,B
A,B
A,B
No
Yes
No
Yes
TGAI 10/
TGAI
A,B
A,B
Yes 00114201, 00114232
00114224, 00114226
05010016,
GS128-003
Partially 00114199, 00114250
Yes
00001666
Yes 5/
No
Yes 6/
NO
Yes y
No
July 1991
July 1991
March 1988
64
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TABLE A
GENERIC DATA REQUIREMENTS FOR PCNB
Test
Data Requirement Substance
S158.135 Toxicology - Continued
MUTAGENICITY TESTING
84-2 - Gene Mutation (Ames Test) TGAI
84-2 - Structural Chromosomal TGAI
Aberration
84-2 - Other Mechanisms of TGAI
Mutagenicity
SPECIAL TESTING
85-1 - General Metabolism PAI or PAIRA
< .,':,%*
85-2 - Dermal .Penetration Choice
86-1 - Domestic Animal Choice
Use Does EPA Bibliographic Must Additional Time Frame
Patterns Have Data? Citation Data be for
Submitted? Submission
A,B Yes 00114206,
05009139,
A,B Partially 05009139,
A,B Yes 05009139,
A,B Yes 00060561,
00114207,
00114209,
00114250,
00114256,
No
NO
05003752 No
GS 128-003
GS128-003 Reserved 8/ 12 Months
GS128-003 No
00097800 No
00114208
00114233
00114251
00129446
No 9/
No 9/
Safety
-------
TABLR A
GFNRRIC DATA REQUIREMENTS FOR PCNB
SI58.135 Toxicology - Continued
I/ Technical PCNB is not an organophosphate or degradation product thereof, and it is not structurally related to a
~~ known acute delayed neurotoxic substance.
2/ The chronic feeding study in dogs (114201) satisfies the requirement for a subchronic study in a non-rodent.
3/ No direct application to the skin or prolonged dermal exposures are associated with uses of PCNB.
4/ Repeated inhalation exposure to toxic concentrations is not likely under normal use conditions.
V Generally low survival of test animals «50%) in the long-term rat feeding study makes it unaceptable. The Agency
expects to receive a new chronic toxicity study in July, 1991.
6/ Excessive toxicity or generally low survival of test animals in the long-term rat feeding studies makes the results
inadequate for use in an assessment of PCNB's carcinogenic potential.
7/ Courtney et al (114250) tested a single dose level in small groups (5 to 7 rats per group). In another study
(00114204), PCNB of unspecified purity was tested, and the results did not unequivocally support the conclusion that
the highest dose tested caused maternal toxicity. No maternal data were reported for the low and mid-dose groups so
a NOEL could not he established. In the third study (114199), no observations such as maternal body weight and food
consumption were reported. No effects were noted in the study, and therefore, sufficiently high doses were not
evaluated. Because of HCB's potential developmental toxicity (U.S. EPA, 1984) and the absence of any statement of
maternal or fetal effects, a study in rats is needed. The available mouse study (114250) tested a single toxic
cose, and therefore, cannot he used to establish a NOEL in a second species.
8/ Reserved: The chromosomal abberation study reported by NTP (1968) suggested that PCNB has an effect on chromosome
structure in Chinese hamster ovary cells in vitro. Because there were no other incications of genotoxocity, and
because the effects were not clearly dose-related, the NTP is conducting additional chromosomal abberation studies
to confiem the earlier findings. Additional data may be needed if the results of the new studies confirm those of
the first NTP chromosomal aberration study.
9_/ PCNB use patterns in conjunction with the Guidelines indicate that these data are not required.
10/ In the Toxicology data requirements under Chronic Testing, the technical grade (TGAI) of PCNB to be used for testing
laboratory animals must contain a HCB level equal to or less than 0.1 percent.
66
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TABLE A
GENERIC DATA REQUIREMENTS FOR PCNB
Data Requirement
$158.130 Environmental Fate
DEGRADATION STUDIES-LAB:
161-1 - Hydrolysis
Photodegradation
161-2 - In water
161-3 - On soil
161-4 - In Air
METABOLISM STUDIES-LAB:
162-1 - Aerobic Soil
162-2 - Anaerobic Soil
162-3 - Anaerobic Aquatic
162-4 - Aerobic Aquatic
Test
Substance
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
TGAI or PAIRA
Use Does EPA Bibliographic
Patterns Have Data? Citation
A,B No
A,B No
A,B No
No
A,B No
A No
No
No
Must Additional
Data be
Submitted?
Yes
Yes
Yes
No I/
Yes
Yes
No 2/
No 2/
Time Frame
for
Submission
9 Months
9 Months
9 Months
27 Months
27 Months
MOBILITY STUDIES;
163-1 - Leaching and
Adsorpt ion/Desorpt ion
163-2 - Volatility (Lab)
163-3 - Volatility (Field)
TGAI or PAIRA A,B
TEP A
TEP A
Yes
No
No
0011416B,
00114181,
No
Yes 12 Months
Reserved 3/
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR PCNB
Data Requirement Test
Substance
SI 58. 130 Environmental Fate - Continued
DISSIPATION STUDIES-FIELD:
164-1 - Soil TEP
164-2 - Aquatic (Sediment)
164-3 - Forestry
164-4 - Combination and
Use Does EPA
Patterns Have Data?
A,B No
No
No
No
Bibliographic Must Additional
Citation Data be
Submitted?
Yes
No 2/
No 4_/
No 5/
Time Frame
for
Submission
27 Months
Tank Mixes
164-5 - Soil, Long-term
ACCUMULATION STUDIEJS:
165-1 - Rotational Crops
(Confined)
165-2 - Rotational Crops
(Field)
165-3 - Irrigated Crops
165-4 - in Fish
165-5 - In Aquatic Non-Target
Organisms
TEP
PAIRA
TEP
TGAI or PAIRA
TEP
A,B
A,B
No
No
No
No
No
No
Reserved 6_/
Yes
Reserved 7_/
No 2/
Yes
Yes
39 Months
12 Months
12 Months
68
-------
TABLE A
GFNERIC DATA RFOUIRFMFNTS FOR PCNB
S158.130 Environmental Fate - Continued
_!/ Data are not required because PCNB has low volatility.
2/ Data are not required because PCNB does not have aquatic or aquatic impact uses.
3/ Data are deferred, depending upon the results of laboratory volatility studies.
4/ Data are not required because PCNB does not have forestry uses.
5/ Data for combination products and/or tank mixes are not required for this standard.
6/ Required if residues do not reach 50% dissipation (164-1) prior to recommended subsequent application of PCNB.
7/ Data are deferred, depending upon results of confined accumulation studies.
69
-------
TABUS A
GENERIC DATA REQUIREMENTS FOR PCNB
Data Requirement
Testi/
Substance
Use
Patterns
Does EPA
Have Data?
Bibliographic
t Citation
Must Additional
Data be
Submitted?
Time Frame
for
Submission
SI 58. 125 Residue Chemistry
171-2 - Chemical Identity
171-3 - Directions for Use
171-4 - Nature of Residue
(Metabolism)
- Plants
- Livestock
171-4 - Residue Analytical
Methods
- Plant residues
- Animal residues
TGAI
PAIRA
PAIRA & Plant
Metabolites
TGAI &
Metabolites
TGAI &
Metabolites
No
Partially
Partially
Partially
00001679, 00002827
00114183, 00114184
00114185, 00114186
00114187,
00114205, 00114966
00001678, 00097751
00001570,
00001670,
00001862,
00053075,
00071342,
00097734,
00097738,
00097740,
00097791,
00001669
00001707
00028428
00064197
00097719
00097735
00097739
00097741
00106632
Partially 00014327, 00109656
Yes
Yes 2/
Yes 3/
Yes 4/
Yes 4/
6 Months
18 Months
18 Months
15 months
15 months
70
-------
TABLR A
GENERIC DATA REQUIREMENTS FOR PCNR
Data Requirement
Test!/ Use Does EPA Bibliographic
Substance Patterns Have Data? Citation
Must Additional
Data be
Submitted?
Time Frame
for
Submission
$158.125 Residue Chemistry
171-4 - Storage Stability Data PAI
171-4 - Magnitude of the
Residue-
a. Root 6 Tuber Vegetable 7_/
o Potato
— Crop field trials TEP
Partially 00059120
Yes 5/
Partially 00001861,00097742 Yes 6a/
15 Months
18 Months
— Processed Food/Feed EP
b. Bulb Vegetable 8/
o Garlic
— Crop field trials TEP
Partially
00059933, 00129447
00156362, 00159016
Partially 00097786,
Yes 6b/
Yes 9/
August 198R
18 Months
c. Leafy Vegetables 10/
o Lettuce
—Crop field trials TEP
d. Brassica (Cole) Leafy
Vegetables 16/
o Broccoli
— Crop field trials TEP
Partially 00097715, 00097764 Yes ll/
Ace.115742
Partially 00097736,
Yes 12/
18 Months
18 Months
71
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TABLE A
GENERIC DATA REOUIRRMENTS FOR PCNB
Data Requirement
Test!/ Use Does FPA Bibliographic
Substance Patterns Have Data? Citation
Must Additional
Data be
Submitted?
Time Frame
for
Submission
SI58.125 Residue Chemistry
.171-4 - Magnitude of the
Residue-
d. Brassica (Cole) Leafy
Vegetables (continued)
o Brussels Sprouts
— Crop field trials TEP
o Cabbage
— Crop field trials TEP
o Cauliflower
— Crop field trials TEP
e. Legume Vegetable 19/
o Beans
— Crop field trials TEP
— Processed Food/Feed EP
f. Fruiting Vegetables 22/
(Except Cucurbits)
o Peppers
—Crop field trials TEP
o Tomatoes
— Crop field trials TEP
— Processed Food/Feed EP
Yes 13/
Partially 00001861, 00097720 Yes 14/
No
Partially
No
00001861, 00097734
00097764, GS128-001
Yes 15/
Yes IT/18/
Yes 17b/
Partially 00097801,
Yes 20/
Partially 00001861,00097743 Yes 21a/
No Yes 21 b/
18 Months
18 Months
18 Months
18 Months
18 Months
18 Months
18 Months
18 Months
72
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TABLE A
GENRRTC DATA REQUIREMENTS FOR PCNB
Data Requirement
Test!/ Use
Substance Pa t te rns
DORS EPA Bibliographic
Have Data? Citation
Must Additional
Data he
Submitted?
Time Frame
for
Submission
SI58.125 Residue Chemistry
171-4 - Magnitude of the
Residue-
g. Small Fruits & Berries 24/
o Strawberries
— Crop field trials TEP
h. Non-Grass Animal Feeds
(Forage, Fodder,
Straw & Hay) 27/
o Alfalfa
— Crop field trials TEP
o Clover
— Crop field trials TEP
i. Miscellaneous
Commodities
o Bananas
— Crop field trials TEP
o Cottonseed
'— Crop field trials, TEP
Processed Food/Feed
Partially 00097733,
GS128-002
Partially 00097738
Yes 23/
Partially 00001707, 00097738 Yes 25/
Yes 26/
Partially 00097749, 00106632 Yes 28/
Partially 00001704, 00002228 Yes 29/
00028427, 00064194
00097740, 00109402
18 Months
18 Months
18 Months
18 Months
18 Months
-------
TABLK A
GENERIC DATA REQUIREMENTS FOR PCNB
Data Requirement
•Testi/ Use
Substance Patterns
Does RPA Bibliographic
Have Data? Citation
Must Additional
Data be
Submitted?
Time Frame
tor
Submission
S158.125 Residue Chemistry
171-4 - Magnitude of the
Residue-
i. Miscellaneous
Commodities (continued)
o Peanuts
— Crop field trials
j. Seed Treatments
— Field trials
k. Fat,Meat,Meat By-
Products & Milk of
Cattle,Goats,Hogs,
Horses, & Sheep
TCP
— Processed Food/Feed EP
TCP
TGAI or Plant
Metabolites
1. Fat,Meat,Meat By- TGAI or Plant
' Products & Eggs of Metabolites
Poultry
Partially
Partially
Partially
00001704, 00001859
00001862, 00031296
00103131, 00125805
GS128-003
00059932, 00060784
00097741, GS128-003
00053075, 00059146
00059149, 00059155
Partially 00014326
Yes 30/31/
Yes 32/
Yes 33/34/
Reserved 35/
Partially 00097757, 00109656 Reserved 36/
18 Months
18 Months
18 Months
74
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TABLE A
GKNRRIC DATA REOUIRRMKNTS FOR PCNB
Data Requirement
Test!/
Substance
Use
Patterns
Does EPA
Have Data?
Bibliographic
Citation
Must Additional
Data be
Submitted?
Time Fra
for
Submission
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue -
Residue Studies
- Potable Water
- Fish
- Irrigated Crops
- Food Handling
171-5 - Reduction of Residue
171-6 - Proposed Tolerance
171-7 - Reasonable Grounds in
Support of Petition
EP
EP
EP
EP
Residue of
Concern
Residue of
Concern
No
No
No
No
No
No
No
Reserved 37/
Reserved 37/
Reserved 37_/
Reserved 37/
Reserved 38/
Reserved 38/
Reserved 38/
75
-------
If \Mlif, fS
GKNRIUC DATA RRQUIRRMENTS FOR PCNB
S 158.125 Residue Chemistry - Continued
\J The PCNB test substance to be used as specified for each data requirement must be that substance which is
currently produced and marketed.
2/ The nature of the residue in plants has not been adequately described. Therefore, the following data must
~ be provided: Data reflecting the distribution and metabolism of benzene-labeled ('^CJPCNB in mature peanuts
and peanut forage, cabbage, and potatoes following soil applications (timed according to registered uses) at
rates sufficiently high to permit complete characterization of ^C-residues. Analyses should include
hydrolysis and reextraction of extracted plant residues and aqueous fractions to determine conjugated 14C-
residues. l^ClPCNB-treated samples should also be analyzed by enforcement method(s) to ascertain that
all metabolites and impurities of concern are adequately determined.
3/ The nature of the residue in animals has not been adequately described. Therefore, the following data must
be submitted: Metabolism studies utilizing ruminants and poultry, dosed with benzene-labeled [^ClPCNB
for at least 3 days at a concentration in the total diet which will result in sufficient residues in the
tissues, milk and eggs for characterization. Animals must be sacrificed wjlthin 24 hours of the
final dose. Milk and eggs must be collected twice daily. The distribution and characterization of
PCNB residues must be determined and quantitated in milk, muscle, fat, kidney and liver of cows, and
in the eggs, muscle, fat, kidney and liver of poultry. Analyses should include hydrolysis and reextraction
of extracted samples and aqueous fraction to determine any conjugated l^C-residues. Samples from these
studies must also be analyzed by the enforcement method(s) to ascertain that all metabolites and impurities
of concern are adequately determined.
4_/ The registrant must submit the following data: Complete descriptions of analytical methods, including vali-
dation data and representative chromotograms, for the detection and quantitation of all residues and impurities
of concern in or on plant and animal commodities.
V No data have been submitted concerning the storage stability of PCNB in or on raw agricultural commodities
from crops treated with PCNB. The following data are required:
a. Storage intervals and conditions must be provided for plant samples used to generate data to support
the interim or established tolerances for residues of PCNB, per se, in or on the following commodities
and their processed products: potatoes, a brassica leafy vegetable, beans, peppers, tomatoes, cotton-
seed and peanuts. These data must be accompanied by data depicting the percent decline in residues
at the corresponding storage intervals under the reported conditions. On receipt of these data, the
sufficiency of the data regarding tolerance assessment will be reevaluated.
b. Similarly, sample storage information and residue storage stability data must be reported for residues
of PCNB, PCA, MPCPS, PCB and HCB (See page 5 of this Standard) in or on the crop and animal R.A.C.s for
which tolerances are currently proposed.
c. All residue data requested in this Standard must be accompanied by data regarding storage length and
conditions of storage of samples. These data must be accompanied by data depicting the stability
of the residues of concern under the conditions and for the time intervals specified.
76
-------
GKNRRFC DATA REQUIREMENTS FOR PCNB
S 158.125 Residue Chemistry
6/ The following data are required for potatoes:
a. Studies depicting residues of concern in or on potatoes treated with the 10 or 30% G, 75% WP, or 24% EC
formulation of PCNB applied (i) PPI (preplant incorporated) broadcast at 25 Ib ai/A; and (ii) in-
furrow at planting at a rate of 11.7 Ib ai/field A (separate tests). Studies must be conducted in the
following areas: CA, ID, OR/VIA, MI/VJI, MN/ND, ME and FL. This geographic distribution is representative
of ca. 95% of U.S. potato production (Agricultural Statistics, 1983).
b. Submit a potato processing study following the RGB approved protocol as follows: (i) use a ca. 5x
treatment rate (50 Ib ai/field A applied in-furrow) to produce potatoes bearing measurable weathered
• residues of PCNB; (ii) submit complete field sample and storage information; (iii) process 50 Ib each
of untreated and treated potatoes into chips, granules, and flakes; (iv) submit complete descriptions
of the processing procedures; (v) analyze samples for all residues of concern; (vi) submit complete
descriptions of the analytical methods and limits of detection; (vii) submit chromatrograms and raw
data for all analyses; and (viii) accurately report all raw and summary data, reflecting the reported
analytical limits of detection. Appropriate food/feed additive tolerances must be proposed should
residues concentrate in the processed products.
7/ To obtain a crop group tolerance, residue data would be required for potatoes (see footnotes 5a & 5b) as
well as the additional Root and Tuber Vegetable crops, carrots, radishes and sugarbeets.
8/ To obtain a crop group tolerance, residue data would be required for the additional Bulb Vegetable crop,
onions.
9/ The registrant must: clarify the current labeling for the in-furrow treatment by specifying the spray band
width as well as the number of row feet per field A.
10/ To obtain a crop group tolerance, the registrant would have to propose a tolerance for the combined residues
of concern in or on lettuce (leaf and head) and submit appropriate supportive data. Residue data would
also be required for the additional Leafy Vegetable crops, celery and spinach.
77
-------
TABLR A
GFNFRIC DATA REOUIRRMENTS FOR PCNB
§ 158.125 Residue Chemistry
ll/ The submitted data are insufficient for assessment of maximum expected residues of PCNB (per se) or the
combined residues of PCNB, its metabolites PCA and MPCPS, and its impurities PCB and HCB in or on lettuce
for the following reasons: (i) the data did not adequately represent the various registered formulations; (ii)
the treatment regimens did not reflect those currently labeled; (iii) sample histories were not adequately
reported; and (iv).much of the data did not represent the R.A.C.s because samples were routinely washed in
water before analysis. Therefore, the registrant must either;
a. Propose a tolerance for the combined residues of PCNB and its metabolites and impurities of concern in
or on lettuce and submit data to support that tolerance. Trials must be conducted in accordance with
the current intrastate labels on both leaf and head lettuce in AZ using the 2 lb/ gal EC, in CA
using the 40% D and 75% WP (in separate trials), and in TX using the 10% D. Samples must be collected
at crop maturity and, for head lettuce, must include both untrimmed and. f ieldtrimmed heads. The
manner and extent of trimming must be adequately described. Also, the registrant must propose label
restrictions specifying a minimum treatment-to-harvest interval, which must be reflected by data.
Finally, the registrant must clarify the current labeling for the banded treatments by specifying
the number of treated row feet/field A, in addition to the spray band width, or
b. Cancel the current intrastate registrations (AZ State Reg. No. N; CA State Reg. No. 10972-50043 AA and
10972-50199 AA; and TX State Reg. No. 74).
12/ Additional data are required for broccoli:
a. Data for the combined residues of ^PCNB and its metabolites and impurities of concern in or on broccoli
treated with 75% WP and 10% G formulations (in separate treatments) in a broadcast incorporated treatment
at ca. 60 lb ai/A before transplanting; and incorporated in a 12-15 inch band at 40 lb ai/field A (13,000
row feet) at transplanting. Data are also required from trials conducted with the 75% WP applied at ca.
60 lb ai/field A in a transplant solution according to the current label. Trials must be conducted at one
OR and two CA (one trial each in the central coast area and Imperial Valley) sites; or in one location
each in CA (central coast), OR and TX to adequately represent the commercial production areas of broccoli
in the U.S. (Agricultural Statistics, 1984).
b. The registrant must also propose a label restriction limiting the maximum annual application rate, which
must be reflected by the data.
78
-------
TABLE A
GENERIC DATA REOIIIREMKNTS FOR PCNB
S 158.125 Residue Chemistry
13/ No data were submitted regarding residues of PCNB, its metabolites or its impurities in or on brussels
sprouts. However, the tests are not required because data required for broccoli and/or cabbage will also he
used for brussel sprouts.
14/ Additional data are required for cabbage:
a. Data for the combined residues of PCNB and its metabolites and impurities of concern in or on cabbage
(with and without wrapper leaves) from trials conducted with 75% WP and 10% G formulations (in separate
treatments) broadcast at ca. 60 Ib ai/A and incorporated before transplanting; and incorporated in a
12-15 inch band at 40 Ib ai/ field A (13,000 row feet) at transplanting. Data are also required from
trials conducted with the 75% WP applied at ca. 60 Ib ai/ field A in a transplant solution according to
the current label. Trials must be conducted in CA, FL, NY, TX, and WI to adequately represent the
commercial production areas of cabbage in the U.S. (Agricultural Statistics, 1981).
b. The registrant must also propose a label restriction limiting the maximum annual rate, which must be
reflected by the data.
15/ No data were submitted regarding residues of PCNB, its metabolites or its impurities in or on cauliflower.
However, the tests are not required because data required for broccoli and/or cabbage will also
be used for cauliflower.
16/ To obtain a crop group tolerance, additional data would be required for broccoli and cabbage (see above) as
well as for one additional Brassica (Cole) Leafy Vegetable crop, mustard greens.
79
-------
TABLK A
GENERIC DATA Rh)OUIRFMRNTS FOR PTNR
S 158.125 Residue Chemistry
IT/ The available data are insufficient for assessing either the interim tolerance for residues of PCNB, per
se, or the proposed tolerance for the combined residues of PCNB, PCA, MFCPS, PCB and HCB in or on snap, lima
or dry beans. The data are insufficient because no data represented the treatment regimen of consequence:
a cummulative rate of 7.5 Ib ai/A/season directed in split applications to the soil, through first bloom.
Therefore, the registrant must submit:
a. Data depicting residues of. concern in or on snap, lima (succulent) and dry beans treated with the
10-75% D, 75% WP and 23-25% F,C formulations (in separate treatments) at a total of 7.5 Ib ai/A/season
applied in split applications of 1.5 + 2.0 + 2.0 + 2.0 Ib ai/field A at two-week intervals through
first bloom as a directed spray to the soil in a band at the base of the plants. To adequately represent
the geographic distribution of U.S. production (Agricultural Statistics, 1981) of snap beans, succulent
limas, and dry beans, geographical representation must include trials conducted in (i) FL, NC/VA, NY
and OR representing 65% of snap beans production; (ii) CA, DE/MD and WI representing 77% of lima
bean production and (iii) CA, CO, ID, MI and ND, representing 85% of dry bean production, including
navy, pinto and red kidney bean varieties.
b. Data from cannery residue from processed snap beans bearing measurable weathered residues of PCNB.
An appropriate feed additive tolerance must be proposed if PCNB residues concentrate in the cannery
residue.
c. Additionally, the registrant must (i) propose a label restriction specifying a minimum treatment-to-
harvest interval, which must be reflected in the required data; and (ii) propose separate tolerances
for snap, lima (succulent) and dry beans to reflect the current registered uses.
18/ To support the current registration for special local use on dry and snap beans in Michigan
(SLN MI-820007), the registrant must submit:
a. Data concerning residues of concern in or on dry and snap beans from MI treated with the 75% WP at a
cummulative rate of 7.5 Ib ai/A-resulting from split applications at 0.5 + 2.0 + 5.0 Ib ai/field A
applied at two-^week intervals through first bloom in a directed spray to the soil in a band at the
base of the plants.
b. Also, the registrant must propose a minimum treatment to harvest interval, which must be reflected by
the requested data.
19/ To obtain a crop group tolerance, additional data will be required for succulent and dry beans (see above)
and also for the additional Legume Vegetable crops, peas (succulent and dry) and soybeans.
-------
TABLE A
GF.NERIC DATA REQUIREMENTS FOR PCNB
S 158.125 Residue Chemistry
20/ The available data are insufficient for assessing the adequacy of either the interim tolerance for PCNB
(per se) or the proposed tolerance for the combined residues of PCNB, its metabolites PCA and MPCPS, and
its impurities PCB and HCB in or on peppers because (i) no data represented the labeled pretransplant in-
furrow treatment; (ii) the geographic representation of the data from the transplant solution treatment was
inadequate; and (iii) no data depicted residues of PCNB metabolites and/or impurities. The data submitted
for tomatoes are not appropriate for data translation. Therefore, the registrant must submit:
Data depicting residues of PCNB and its metabolites and impurities of concern in or on peppers treated
with the 75% WP formulation applied at 7.5 Ib ai/field A in-furrow at transplanting and at 34.0 Ib
ai/field A in a transplant solution. Studies must he conducted in CA, FL, NJ and TX ,to adequately
represent (ca. 64%) U.S. pepper production (1982 Census of Agriculture, Vol. 1).
21/ The available data are not sufficient to assess the adequacy of either the interim tolerance for PCNB (per
se) or the pending tolerance for the combined residues of PCNB, its metabolites PCA and MPCPS, and its
impurities PCB and HCB in or on tomatoes for the following reasons: (i) the application rates and methods
did not represent the labeled maximum rates and application methods; (ii) adequate sample histories were
not provided; and (iii) no data were provided for residues in processed tomato products. The data submitted
for peppers are not appropriate for translation to tomatoes. Therefore, the registrant must submit:
a. Residue data depicting the combined residues of PCNB and its metabolites and impurities of concern in or
on tomatoes treated with the 75% WP formulation applied at 7.5 Ib ai/field A infurrow at transplanting
and at 25.5 Ib ai/field A (staked tomatoes) in a transplant solution. Studies must be conducted in
CA(2), FL, IN/MI/OH, and DE/MD/NJ to adequately represent (ca. 82%) the commercial tomato production
in the U.S. (1982 Census of Agriculture, Vol. 1).
b. Residue data from the processed products of tomatoes, including wet and dried pomace, puree, catsup and
juice processed from tomatoes containing measurable weathered residues of PCNB. Appropriate food/feed
additive tolerances must be proposed should the residues concentrate in the processed products.
22/ To obtain a crop group tolerance, the data requirements for tomatoes and peppers outlined above in footnotes
;19 and 20 must be met.
81
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR PCNB
S 158.125 Residue Chemistry
23/ The submitted data are insufficient for assessment of maximum expected residues of PCNB (per se) or the com-
bined residues of PCNB, its metabolites PCA and MPCPS, and its impurities PCB and HCB in or on strawberries
for the following reasons: sample histories were not adequate; and/or application rates and methods did
not reflect the labeled use directions. The registrant must either:
a. Propose a tolerance for the combined residues of PCNB and its metabolites and impurities of concern in
or on strawberries and submit appropriate and sufficient data in support of that tolerance. Trials
must be conducted with the 75% WP in CA and reflect the currently labeled application methods and
maximum use rates. In the case of the of posttransplant bed spray (banded?), the registrant must
clarify the use rate by specifying the dose per application, the band width (if banded), the number
of treated row feet per field A, and the application volume per A. The required residue data must
reflect these clarified directions for use, or
b. Cancel the current intrastate registration (CA State Reg. No. 10972-50199 AA).
24/ To obtain a crop group tolerance, data will be required for strawberries (see footnote 22) and for the
additional Small Fruits & Berries crops: blueberries, cranberries and grapes.
25/ The submitted data are insufficient for determination of maximum expected residues of PCNB (per se) or the
combined residues of PCNB, its metabolites PCA and MPCPS, and its impurities PCB and HCB in or on alfalfa
forage and hay. The data were insufficient because they did not represent (i) forage and corresponding hay
samples; (ii) samples from crops treated with multiple applications to successive cuttings; and (iii) desert
conditions typical of AZ production areas. The available clover data are inappropriate for translation.
The registrant must either;
a. Propose tolerances for the combined residues of PCNB and its metabolites and impurities of concern in
or on alfalfa forage and hay, and submit data to support those tolerances. Trials must be conducted
with the 2 Ib/gal EC in AZ, and reflect multiple application treatments at 12 Ib ai/A in 100 gal of
water/A applied within 7 days after each of three successive cuttings. Samples of forage and hay
must be collected after the third application. The registrant must also propose label restrictions
limiting the maximum annual rate and specifying a minimum treatment-to-harvest interval, which must be
reflected in the requested data; or
b. Cancel the current intrastate registration (AZ State Reg. No. "N", EPA Ace. No. 05009).
82
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TABI.K A
OKNKRIC DATA RROIJIRF.MENTS FOR PCNB
S 158.125 Residue Chemistry
26/ The submitted data are insufficient for determination of maximum expected residues of PCNB (per se) or the
combined residues of PCNR, its metabolites PCA and MPCPS, and its impurities PCB and HCB in or on clover
forage or hay because the data did not represent (i) forage and corresponding hay samples; (ii) samples from
crops" treated with multiple applications to successive cuttings; and (iii) trials conducted at locations
representative of the desert production conditions in AZ. The data submitted for alfalfa were inappropiate
for translation. The registrant must either:
a. Propose tolerances for the combined residues of PCNB concern in or on clover forage and hay, and submit
data to support those tolerances. Data for alfalfa may be translated for this purpose. The registrant
must also propose label restrictions limiting the maximum cummulative annual rate and specifying a
minimum treatment-to-harvest interval, which must be reflected in the requested data; or
b. Cancel the current intrastate registration (AZ State Reg. No. "N", EPA Ace. No. 05009).
27/ To obtain a crop group tolerance, data will be required for alfalfa and clover (see footnotes 24 and 25).
For purposes of a crop group tolerance, actual residue data for clover (rather than data translated from
alfalfa) will be required.
28/ The submitted data are insufficient to assess the adequacy of either the interim.tolerance for PCNB, per
se, or the proposed tolerance for the combined residues of PCNB, its metabolites PCA and MPCPS, and its
impurities PCB and HCB in or on bananas because: (i) no data represented the treatment regimen most likely
to result in the highest residues; (ii) samples were not representative of the R.A.C.; (iii) residues of
PCNB in or on the control samples are considered unacceptably high; and/or (iv) no data were presented
fpr residues of pentachloroaniline (PCA), S-methyl pentachlorophenyl sulfide (MPCPS), and pentachlorobenzene
(HCB) in or on treated bananas. Therefore, the registrant must:
a. Submit data depicting residues of PCNB and its metabolites and impurities of concern in or on bananas
treated with the 1.63% RTU paste applied postharvest at 1 gallon product/700-800 stems by dipping
the butt and tipend of the stalk, and brushing the remainder of the dose onto cuts and scrapes along
the stems. Whole bananas (peels plus pulp, stem and crown tissue removed) shall be analyzed. Because
the data indicate that residues may concentrate in or on the fruit during shipment, bananas (from the
same bunch) must be analyzed immediately after treatment and again after arrival at the U.S. port of
entry following intercontinental shipment under representative transport conditions. The data must
depict minimum and maximum shipment intervals representative of those anticipated for transportation
to various U.S. ports of entry.
b. The registrant(s) must submit copies of the labels for all PCNB products presently used in countries
which export bananas to the U.S.
83
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TAHLR A
GFNRRTC DATA REQUIREMENTS FOR PTNR
S 158. 125 Residue Chemistry
29/ The submitted data indicate that the present tolerance for residues of PCNB, per se, in or on cottonseed
is inadequately low. Tolerance-exceeding residues (£0.78 ppm) have been detected in several samples from
0.5x treatment rates. However, the available data are not sufficient to determine an appropriate tolerance
level because (i) data from only two locations (or samples) represented the maximum labeled rate; (ii)
sample handling procedures may have removed or allowed deterioration of residues before analysis; and
(iii) sample histories were frequently deficient in one or more aspects.
Data for the processed products of cottonseed are inadequate because no data for cottonseed hulls, soapstock
or refined oil were submitted. However, the data show that residues of PCNB, per se, in or on cottonseed
do concentrate by ca. 6x factor in the crude oil. Therefore, additional data are required for cottonseed
and its processed products:
a. Data depicting residues of PCNB and its metabolites and impurities of concern in or on cottonseed treated
with a registered WP or EC, and a G formulation (in separate treatments) applied infurrow at 2 Ib
ai/field A. Treatments must also be conducted with a G at 2 Ih ai/field A applied in a surface band
over the row at planting. Studies must be conducted in AZ (9%), CA (25%), MS (12%), LA (7%), and TX
(31%), including the Rio Grande Valley, to adequately represent U.S. commercial cottonseed production
(values in parentheses represent % of total U.S. production according to Agricultural Statistics,
1984, p. 62). An appropriate tolerance revision must be proposed.
b. Although inadequate, the available processing study showed that the combined residues of PCNB and its
metabolites, PCA and MPCPS,'and impurities, PCB and HCB, did not concentrate in the meal. However, be-
cause the combined residues concentrated by a factor of 6x in the crude oil, and no data were submitted
for hulls, soapstock, or refined oil, the registrant must submit a cottonseed processing study depicting
the combined residues of concern in the hulls, meal, crude oil, soapstock and refined oil from cottonseed
bearing measurable, weathered residues. Should the combined residues concentrate in the meal, hulls,
soapstock or refined oil, appropriate food/feed additive tolerances must be proposed for those processed
commodities. If the only residues of concern are found to be PCNB, PCA, MPCPS, PCB, and HCB, no addi-
tional analyses of meal or crude oil are needed.
30/ The available data are insufficient to assess the adequacy of either the interim tolerance for residues of
PCNB, per se, in or on peanuts, or the proposed tolerances for the combined residues of PCNB, its metabolites
.PCA and MPCPS, and impurities PCB and HCB in or on peanuts and peanut hulls because (i) insufficient data
were submitted depicting residues resulting from at-pegging treatments at 10 Ib ai/A broadcast either
aerially or via overhead sprinkler, or 10 Ib ai/field A banded applied 45 days before harvest; (ii) the majo-
rity of the nutmeat samples did not represent the R.A.C. because they were washed before residue analysis;
and (iii) sample histories were frequently incomplete. Therefore, the following additional data are
required:
84
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TABLE A
GENERIC DATA REQUIREMENTS FOR PCNB
§ 158. 125 Residue Chemistry
Residue data depicting residues of concern in or on peanut nutmeats and hulls harvested 45 days after an
(at-pegging) surface-banded application of the 10 or 30% G, and 75% WP formulation (in separate trials)
applied at 10 Ih ai/field A. Tests must be conducted in AL, FL/GA, NC/VA, OK and TX to adequately
represent (>80%) U,S. commercial peanut production (Agricultural Statistics, 1984).
31/ To support the various intrastate labels and SLN registrations, the registrant must submit:
a. Data for the combined residues of PCNB and its metabolites and impurities of concern from peanut
nutmeats and hulls harvested 45 days after an at-pegging fungigation treatment (via overhead sprinkler)
at 10 Ib ai/A. Trials must be conducted with the 75% WP formulation in OK and TX, and appropriate 2
Ib/gal EC formulations in AL, GA and TX.
b. Submit residue data for peanuts and their hulls to support the registered special local use in TX for
(at-pegging) aerial broadcasts of the 10% G at 10 Ib ai/A. The registrant must also propose a label
restriction specifying a minimum treatment-to-harvest interval for this use, which must be reflected
in the requested data.
32/ None of the available processing studies is adequate to assess potential residue concentration during
fractionation into the processed products. Therefore, the registrant must submit a peanut processing
study depicting the combined residues of concern in the meal, crude oil, soapstock and refined oil
processed from raw peanuts bearing measurable, weathered residues. Should the combined residues concen-
trate in any of the processed commodities, appropriate food or feed additive tolerances must be proposed.
33/ Although no residues of PCNB, per se, were detected in or on the seed of sorghum, or the seedlings, roots
and foliage of sugar beets grown from PCNB-treated seed, residue accountability was not sufficient to
demonstrate no uptake and translocation of PCNB metabolities and/or impurities from the treated seed
into the aerial portions of these crops. Additionally, no data were submitted for barley, corn, oats,
peas, rice, saffl.ower and wheat. Therefore, in order to maintain the non-food use classification for
these seed treatment uses of PCNB, the registrant must submit radiotracer studies using benzene-labeled
[14C]PCNB to determine whether uptake and translocation of residues (radioactivity) into the food/feed
commodities of corn, peas, rice, safflower, sugar beets and wheat occurs (these are considered representa-
tive commodities). Studies must be conducted at the respective maximum labeled rates for the seed treatments
of these respective crops.
85
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TABLF A
GKNFRIC DATA REQUIREMENTS FOR PCNB
$ 158.125 Residue Chemistry
34/ For soybeans, finite residues of PCNB, per se, were £0.041 ppm in or on the leaves from a crop treated at
0.7x the maximum labeled rate. Consequently, this PCNB use must be considered to be a food use. Therefore,
the registrant must propose a tolerance for residues of concern in or on soybean forage and hay, and in or
on soybeans. The registrant must submit data to support that (tolerance. Studies must be conducted with
the 30% D, 25% BC and 17% FLC formulations applied at 0.75 Ib ai/bu as a seed treatment. The dose must be
verified by analysis. Trials must be conducted in AR/LA/MS, AL/GA, TL, posttreatment MN, MO, NC/VA, and
OH to represent >82% of U.S. soybean production (Agricultural Statistics, 1984).
35_/ There are no registered direct-animal treatments for PCNB formulations on cattle, goats, hogs, horses or
sheep. However, the available data indicate that PCNB residues (including its impurities) will transfer to
the tissues and milk of livestock. Therefore, when appropriate feeding levels of PCNB and its metabolites
and impurities of concern can he determined (based on required metabolism and residue data), appropriate
feeding studies will be required.
Since the metabolism of PCNB in animals is not adequately understood, the residues of concern will be
determined following receipt and evaluation of requested animal metabolism studies.
36/ There are no registered direct-animal treatments for PCNB formulations on poultry. When all established
and proposed PCNB tolerances for residues in or on commodities that are fed to poultry have been assessed
and found adequate, and the requested poultry metabolism data have been received and evaluated, the data
from the study conducted with Red Comet chickens will be assessed to determine its adequacy for setting
tolerances for the residues of PCNB and.its metabolites and impurities of concern in the meat, meat by-
products, and eggs of poultry.
37/ These requirements are reserved until such time as data indicate that the magnitude of PCNB residues at
these sites pose concerns.
38/ These requirements "are reserved until such time as the plant, animal and related residue data for PCNB
have been received and reviewed for regulatory considerations.
86
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TABLF. A
GKNFRIC DATA REQUIREMENTS FOR PCNB
Data
S158.
Requirement
145 Wildlife and
Test!!/ Use
Substance Pattern
Does RPA
Have Data?
Bibliographic - Must Additional
Citation Data be
Submitted?
Time Frame
for
Submimission
Aquatic Organisms
AVIAN
71-1
71-2
71-3
71-4
71-5
AND MAMMALIAN TESTING
- Acute Avian Oral Toxicity
- Avian Subacute Dietary
Toxicity
a. Upland gamebird
b. Waterfowl
- Wild Manmal Toxicity
- Avian Reproduction
a. Upland gamebird
b. Waterfowl
- Simulated and Actual
TGAI A,B
TGAI A,B
TGAI A,B
TGAI A,B
TGAI A,B
TGAI A,B
TGAI A,B
No
Partially
Partially
No
No
No
No
Yes
00114165 Yes I/
00114164 Yes I/
No y
Yes V
Yes V
Reserved 4/
9 Months
9 Months
9 Months
24 Months
24 Months
Field Testing for
a. Mammals
b. Birds
87
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TABLE A
GENERIC DATA REQUIREMENTS FOR PCNH
Data
$158
Requirement
.145 Wildlife and
Aquatic Organisms -
TestJJ/
Substance
Uso
Pattern
Does EPA Bibliographic
Have Data? Citation
Must Additional
Data be
Submitted?
Time Fr
for
Submission
AQUATIC ORGANISM TESTING
72-1
_-
72-2
72-3
72-4
- Freshwater Fish Toxicity
a. Warmwater
b. Coldwater
- Acute Toxicity to
Freshwater Invertebrates
- Acute Toxicity to
Estuarine and Marine
Organisms
- Fish Early Life Stage,
and
Aquatic Invertebrate
TGAI
TRP
TGAI
TEP
TGAI
TGAI
TGAI
TGAI
A,R
B
A,B
B
A,B
A
A,B
A,B
No
No
No
No
Yes 00114167
No
No
No
Yes
Yes 5/
Yes
Yes 5/
No
Yes 6/
Yes 7/
Yes 7/
9 Months
9 Months
9 Months
9 Months
12 Months
15 Months
15 Months
Life-Cycle
72-5 - Fish - Life-Cycle
TGAI
A,B
No
Reserved 8/
27 Months
88
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TABLK A
GFNFRIC DATA REOUIRFMENTS FOR PCNB
Data Requirement Te.st_!J/ Use D"655 RPA Bibliographic Must Additional Time Fr
Substance Pattern^/ Have Data? Citation Data be for
_ __ Submitted? __ Submission
S158.145 Wildlife and
Aquatic Organisms - Continued
72-6 - Aquatic Organism TGAI A,B No No 9/
Accumulation
a. Crustacean
b. Fish
c. Mollusk
' d. Insect Nymph
72-7 - Simulated or Actual Field TKP A,B No Reserved 10/
Testing for Aquatic
Organ i fans
I/ Available data indicate LCso > 5000 ppm for both species. However, in view of extremely high residue levels
expected following application at higher rates, these tests must be repeated at higher dose levels.
2/ Available data indicate PCNB is low in toxicity to mammals and its use patterns will not cause adverse effects
to wild mammals.
3/ Data from this test are required to support uses of turf and beans.
4/ Requirement is reserved pending receipt of avian dietary and acute oral data and appropriate fate data.
5/ Data are required for warmwater and coldwater spp. , using the 2.0 Ib/gal emulsifiable concentrate formualtion.
6/ Data from these tests are required to support uses on turf and peanuts.
7/ To support uses on turf, cotton, and peanuts, data from both studies are required.
8/ Reserved pending receipt of environmental fate data and data from fish early life-stage test.
9/ Requirements are deferred, pending upon the results of environmental accumulation studies in fish and aquatic
non-target organisms.
10/ Requirement is reserved pending receipt of acute LC5Q data for fish and environmental fate data.
ll/ The test "substance must contain an HCB level equal to or less than 0.1%.
89
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TABLR A
GFNRRIC DATA REOUIREMRNTS FOR PCNB
Data Requirement
Test Use Does RPA Bibliographic
Substance Pattern Have Data? Citation
Must Additional
Data be
Submitted?
Time Frame
for
Submission
§158.155 Nontarget Insect
NONTARGET INSECT TESTING -
POLLINATORS:
141-1 - Honey bee acute
contact toxicity
141-2 - Honey bee - toxicity
of residues on
foliage
141-4 - Honey bee subacute
feeding study
141-5 - Field testing for
pollinators
NONTARGET INSECT TESTING -
AQUATIC INSECTS;
142-1 - Acute toxicity to
aquatic insects
142-1 - Aquatic insect
life-cycle study
142-3 - Simulated or actual
field testing for
aquatic insects
143-1 - NONTARGET INSECT
thru TESTING - PREDATORS
143-3 AND PARASITES
TGAI A,B
TEP A,B
(Reserved) 2/
TEP A,B
(Reserved) 3/
(Reserved) 3_/
(Reserved) 3_/
(Reserved) 3/
No
No
Yes
Reserved I/
9 Months
15 Months
No
Reserved I/
15 Months
90
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TABLE A
GRNERIC DATA RRQUIRRMENTS FOR PCNB
Data Requirement
Test
Substance
Use
Pattern
Does FPA
Have Data?
Bibliographic
Citation
Must Additional
Data be
Submitted?
Time Frame
for
Submission
5158.155 Nontarget Insect con't
I/ Requirement reserved pending receipt of data from honey bee acute contact 1,050 study.
2/ Reserved pending development of test methodology.
3/ Reserved pending Agency decision as to whether the data requirement should be established.
91
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TABLE A
GENERIC DATA REQUIREMENTS FOR PCNB
Data Requirement
5158.140 Reentry Protection
132-1 - Foliar Dissipation
132-1 - Soil Dissipation
133-3 - Dermal Exposure
133-4 - Inhalation Exposure
§158.142 Spray Drift
201-1 - Droplet Size Spectrum
201-1 - Drift Field Evaluation
Special Tests
Test
Substance
TEP
TEP
TEP
TEP
TEP
TEP
Use Does EPA Bibliographic
Pattern Have Data? Citation
A,B,C,D No
A,B,C,D No
A,B,C,D No
A,B,C,D No
Reserved 2/
Reserved 2/
N/A I/
Must Addtl Time Frame
Data be for
Submitted? Submission
No I/
No I/
No I/
No I/
I/ Available data indicate that there are no toxicological concerns with regards to reentry exposure of PCNB
by workers.
2/ Data are not required because PCNB does not fall within Toxicity Category I for acute toxicity and because the
nonvolatile properties and methods of use should minimize exposure of workers reentering
treated fields.
92
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TABLR B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR PCNU: [90% FORMULATION INTERMEDIATE3, EPA REG. NO. 400-4141,
[80% FORMULATION INTERMEDIATEb , EPA REG. NO. 7501-451 ,
Date
SI 58,
Requirement Test .?/ use Does EPA Bibliographic Must Additional Time Frame
Substance Patterns Have Data? Citation Data be for
Submitted Submission
,135 Toxicology
ACUTE TESTING:
81-1
81-2
81-3
81-4
81-5
81-6
81-7
- Acute Oral Toxic ity - Rat MP
- Acute Dermal Toxicity MP
- Rabbit
- Acute Inhalation Toxicity MP
- Rat
- Eye Irritation - Rabbit MP
- Dermal Irritation - Rabbit MP
- Dermal Sensitization -
Guinea Pig MP
- Acute Delayed MP
Neurotoxicity - Hen
A,B Yes 00001555, No
Renner,1980
A,B Yes 00001665, 00001668 No
00001870, 00114220
A,B Yes 00114203, No
A,B Yes 00114203, No
A,B Yes 00001668, 00114220 No
00114222
A,B No — Yes 9 Months
A,B No — No I/
a/ The 90% formulation intermediate serves as a manufacturing use product.
b/ The 80% formulation intermediate serves as a manufacturing use product.
I/ Technical PCNB is not an organophosphate or degradation product thereof, and it is not structurally related to a
known acute delayed neurotoxic substance.
2/ The test substance must contain an HCB level equal to or less than 0.1%.
93
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TABLE B
PRODUCT SPBCIFIC DATA RROUIREMKNTS FOR PCNB: (90% FORMULATION INTERMEDIATE!/. F,PA REG. NO. 400-414),
(80% FORMULATION INTERMEDIATE^/, EPA REG. NO. 7501-451,
Data Requirement Test !/ use Does EPA
Substance Patterns Have Data?
SI 58. 120 Product Chemistry
Product Identity
61-1 - Product Identity & Dis- MP All No
closure of Ingredients
61-2 - Description of Beginning MP All No
Materials & Manufacturing
Process
61-3 - Discussion of Formation of MP All No
Impurities
Analysis and Certification of
Product Ingredients
62-1 - Preliminary Analysis of MP All No
Product Samples
62-2 - Certification of Ingredient MP All No
Limits
62-3 - Analytical Methods to MP All No
Verify Certified Limits
Other Requirements
64-1 - Submit tal of Samples N/A No
Bibliographic
Citation!/
N/A
N/A
N/A
N/A
N/A
N/A
Must Additional Time Frame
Data be for
Submitted? Submission
Yes 6 Months
Yes 6 Months
Yes 6 Months
Yes " 12 Months
Yes 12 Months
Yes 12 Months
No 3/
a/ The 90% formulation intermediate serves as a manufacturing use product.
b/ The 80% formulation intermediate serves as a manufacturing use product.
I/ The PCNB test substance to be used as specified for each data requirement must be that substance which is currently
produced and marketed.
2/ Not applicable. Although product chemistry data may been submitted in the past, the Agency has determined that
these data must be resubmittod for each pesticide. New requirements have been introduced and previously submitted
data must be updated. Therefore bibliographic citations for the old data are not applicable.
3_/ The compound does not require submittal of samples at this time.
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II. LABELING APPENDICES
Summary of Label Requirements and Table
40 CFR 162.10 Labeling Requirements
Physical/Chemical Hazards Labeling Statements
Storage Instructions
Pesticide Disposal Instructions
Container Disposal Instructions
95
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SUMMARY-1
LABEL CONTENTS
40 CFR 162.10 requires that certain specific labeling
statements appear at certain locations on the label. This
is referred to as format labeling. Specific label items listed
below are keyed to thetable atthe end of this Appendix.
Item 1. PRODUCT NAME - The name, brand or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading.
Item 2. COMPANY NAME AND ADDRESS - The name and address
of the registrant or distributor is required on the label.
The name and address should preferably be located at the
bottom of the front panel or at the end of the label text.
Item 3. NET CONTENTS - A net contents statement is
required on all labels or on the container of the pesticide.
The preferred location is the bottom of the front panel
immediately above the company name and address, or at the end
of the label text. The net contents must be expressed in the
largest suitable unit, e.g., "1 pound 10 ounces" rather than
"26 ounces." In addition to English units, net contents may
be expressed in metric units. [40 CFR 162.10(d)l
Item 4. EPA REGISTRATION NUMBER - The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase "EPA Registration No. ," or "EPA
Reg. No." The registration number must be set in type of a
size and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
registration number and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency.
[40 CFR 162.10(e)]
Item 5. EPA ESTABLISHMENT NUMBER - The EPA establishment
number, preceded by the phrase "EPA Est." is the final estab-
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment number on the immediate
container cannot be clearly read through such wrapper or container.
[40 CFR 162.10(f)]
Item 6A. INGREDIENTS STATEMENT - An ingredients statement
is required on the front panel. The ingredients statement must
contain the name and percentage by weight of each active ingredient
and the total percentage by weight of all inert ingredients.
The preferred location is immediately below the product name.
The ingredients statement must run parallel with, and be clearly
distinguished from, other text on the panel. It must not be
placed in the body of other text. [40 CFR 162.10(g)1
96
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SUMMARY-2
Iteih 6B. POUNDS PER GALLON STATEMENT - For liquid agricul-
tural formulations, the pounds per gallon of active ingredient
must be indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS - Front panel
precautionary statements must be grouped together, preferably
within a block outline. The table below shows the minimum type
size requirements for various size labels.
Size of Label Signal Word "Keep Out of Reach
on Front Panel Minimum Type Size of Children"
in Square Inches All Capitals Minimum Type size
5 and under 6 point 6 point
above 5 to 10 10 point 6 point
above 10 to 15 12 point 8 point
above 15 to 30 14 point 10 point
over 30 18 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT - The statement
"Keep Out of Reach of Children" must be located on the front
panel above the signal word except where contact with children
during distribution or use is unlikely. [40 CFR 162.10(h)(1)(ii)]
Item 7B. SIGNAL WORD - The signal word (DANGER, WARNING,
or CAUTION) is required on the front panel immediately below
the child hazard warning statement. [40 CFR 162.10 (h)(l)(i)]
Item 7C. SKULL & CROSSBONES AND WORD "POISON" - On products
assigned a toxicity Category I on the basis of oral, dermal,
or inhalation toxicity, the word "Poison" shall appear on the
label in red on a background of distinctly contrasting color and
the skull and crossbones shall appear in immediate proximity to
the word POISON. [40 CFR 162.10(h)(1)(i)]
Item 70. STATEMENT OF PRACTICAL TREATMENT - A Statement
of practical treatment (first aid or other) shall appear on
the label of pesticide products in toxicity Categories I,
II, and III. [40 CFR 162.10(h)(1)(iii)]
Item 7E. REFERRAL STATEMENT - The statement "See Side
(or Back) Panel for Additional Precautionary Statements" is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
[40 CFR 162.10(h)(l) (iii)]
Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING - The
precautionary statements listed below must appear together
on the label under the heading "PRECAUTIONARY STATEMENTS."
The preferred location is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline. Fach
of the three hazard warning statements must be headed by the
appropriate hazard title. [40 CFR 162.10(h)(2)1.
97
-------
SUMMARY-3
Item "8A. HAZARD TO HUMANS AND DOMESTLC ANIMALS - Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions to be taken to avoid
accident, injury or damage. [40. CFR 162.10(h)(2)(i)]
Item 8B. ENVIRONMENTAL HAZARD - Where a hazard exists to
non-target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage. [40 CFR 162.10(h)(2)(ii)]
Item 8C. PHYSICAL OR CHEMICAL HAZARD - FLAMMABILITY
Precautionary statements relating to flammability of a product
are required to appear on the label if it meets the criteria
in the PHYS/CHEM Labeling Appendix. The requirement is
based on the results of the flashpoint determinations and
flame extension tests required to be submitted for all products.
These statements are to be located in the side/back panel
precautionary statements section, preceded by the heading
"Physical/Chemical Hazards." Note that no signal word is
used in conjunction with the flammability statements.
Item 9A. RESTRICTED USE CLASSIFICATION - FIFRA sec. 3(d)
requires that all pesticide formulations/uses be classified
for either general or restricted use. Products classified
for restricted use may be limited to use by certified applicators
or persons under their direct supervision (or may be subject
to other restrictions that may be imposed by regulation).
In the Registration Standard, the Agency has (1) indicated
certain formulations/uses are to be restricted (Section IV
indicates why the product has been classified for restricted
use); or (2) reserved any classification decision until
appropriate data are submitted.
The Regulatory Position and Rationale states whether
products containing this active ingredient are classified
for restricted use. If they are restricted the draft label(s)
submitted to the Agency as part of your application must
reflect this determination (see below).
If you do not believe that your product should be classified
for restricted use, you must submit any information and
rationale with your application for reregistration. During
the Agency's review of your application, your proposed classi-
fication determination will be evaluated in accordance with
the provisions of 40 CFR 162.11(e). You will be notified of
the Agency's classification decision.
98
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SUMMARY-4
Claaslficatlon Labeling Requirements
If your product has been classified for restricted use,
the following label requirements apply:
1. All uses restricted.
a. The statement "Restricted Use Pesticide" must
appear at the top of the front panel of the label. The
statement must be set in type of the same minimum size
as required for human hazard signal word (see table in 4n
CFR 162.10(h)(1)(iv)
b. Directly below this statement on the front panel,
a summary statement of the terms of restriction must
appear (including the reasons for restriction if specified
in Section I). if use is restricted to certified applicators,
the following statement is required: "For retail sale
to and use only by Certified Applicators o'r persons
under their direct supervision and only for those uses
covered by the Certified Applicator's Certification."
2. Some but not all uses restricted. If the Regulatory
Position and Rationale states that some uses are classified
for restricted use, and some are unclassified, several courses
of action are available:
a. You may label the product for Restricted use.
If you do so, you may include on the label uses that
are unrestricted, but you may not distinguish them
on the label as being unrestricted.
b. You may delete all restricted uses from your
label and submit draft labeling bearing only unrestricted
uses.
c. You may "split" your registration, i.e. , register
two separate products with identical formulations, one
bearing only unrestricted uses, and the other bearing
restricted uses. To do so, submit two applications for
reregistration, each containing all forms and necessary
labels. Both applications should be submitted simul-
taneously. Note that the products will be assigned
separate registration numbers.
Item 9B. MISUSE STATEMENT - All products must bear the
misuse statement, "It is a violation of Federal law to use
this product in a manner inconsistent with its labeling."
This statement appears at the beginning of the directions
for use, directly beneath the heading of that section.
99
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SUMMARY-5
Item 10A. REENTRY STATEMENT - If a reentry interval
has been established by the Agency, it must be included on
the label. Additional worker protection statements may be
required in accordance with PR Notice 83-2, March 29, 1983.
Item 10B. STORAGE AND DISPOSAL BLOCK - All labels are
required to bear storage and disposal statements. These
statements are developed for specific containers, sizes, and
chemical content. These instructions must be grouped and
appear under the heading "Storage and Disposal" in the directions
for use. This heading must be set in the same type sizes as
required for the child hazard warning. Refer to Appendix II,
STOR, PEST/DIS, and CONT/DIS to determine the storage and
disposal instructions appropriate for your products.
Item IOC. DIRECTIONS FOR USE - Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. When followed, directions must be adequate to
protect the public from fraud and from personal injury and to
prevent unreasonable adverse effects on the environment.
UO CFR 162.10]
COLLATERAL LABELING
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, or other written or graphic printed matter which is
referred to on the label or which is to accompany the product
are termed collateral labeling. Such labeling may not bear
claims or representations that differ in substance from those
accepted in connection with registration of the product. It
should be made part of the response to this notice and submitted
for review.
100
-------
SLMMARY-6
LABELING REQUIREMENTS OF THE FIFRA, AS AMENDED
ITEM
1
2
j 3
4
5
l
| 6A
6B
' 7
! 7A
i
;
I 7B
LABEL ELEMENT
Product name
Company name
and address
Net .contents
EPA Reg. No.
EM Est. to.
Ingredients
statement
Pounds/gallon
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
APPLICABILITY
OP REQUIREMENT
products
products
products
All products
All products
All products
Liquid products
where dosage
given as Its.
ai/unit area
All products
All products
All products
PLACEMENT
REQUIRED
Front panel
None
None
None
None
Front- panel
Front panel
Front panel
Front panel
Front panel
ON LABEL
PREFERRED
Center front
panel
Bottom front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel,
immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the main
ingredients
statement
Above signal
word
Immediately
below child
hazard
warning
COMMENTS
If registrant is not the producer, must
be qualified by "Packed for . . . ,"
"Distributed by, . .," etc.
May be in metric units in addition to
U.S. units
Must be in simi lar type size and run
parallel to other type.
May appear on the container instead of
the label.
Text must run parallel with other text
on the panel.
All front panel precautionary statements
must he grouped together, preferably
blocked .
Note type size requirements.
Note type size requirements.
101
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SUMMARY-7
ITEM
7C
7D
7E
B
8A
flP
[ABEL ELEMENT
Skull 6 cross-
bones and word
POISON (in red)
Statement of
Practical
Treatment or
First Aid
Referral
statement
Side/back panel
precautionary
statements
Hazards to
humans and
domestic
animals
Environmental
hazards
APPLICABILITY
OP REQUIREMENT
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxicity
All products
in Categories
I, II, and III
All products
where pre-
cautionary
labeling
appears on
other than
front panel.
All products
All products
in Categories
I, II, and III
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
Category I:
Front panel
unless refer-
ral statement
is used.
Others:
Grouped with
side panel
precautionary
statements.
Front panel
None
None
None
PREFERRED
Both in close
proximity to
signal word
Front panel
for all.
Top or side
of back panel
preceding
directions
for use
Same as above
Same as above
COMMENTS
•<
Must he grouped under the headings in
8A, 8B, and 8C; preferably blocked.
Must he preceded by appropriate signal
word.
Environmental hazards include hee
caution where applicable.
102
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SUMMARY-8
ITEM
8C
9A
9B
10A
10B
IOC
LABEL ELEMENT
i . i
Physical or
chemical
hazards
Restricted
block
Misuse
statement
Reentry
statement
Storage and
disposal block
Directions
for use
APPLICABILITY
OF REQUIREMENT
All pressurized
products, others
with flash
points under
150*P
restricted
products
All products
PR Notice 83-2
or as determined
by the Agency
All products
All products
PLACEMENT ON LABEL
REQUIRED
None
Top center
of front
panel
Immediately
following
heading of
directions
for use
In the
directions
for use
In the
directions
for use
None
PREFERRED
Same as above
Preferably
blocked
Immediately
after misuse
statement
Immediately
before
specific
directions
for use or
at the end of
directions
for use
None
'COMMEOTS
Refer to Appendix II guide
PHYS/CHEM
Includes a statement of the terms of
restriction. The words "RESTRICTED USE
PESTICIDE" must be same type size as
signal word.
Required statement is:
"It is a violation of Federal law
to use this product in a manner
inconsistent with its labeling."
Must be set apart and clearly distin-
guishable from from other directions
for use.
Refer to Appendix II guides STOR,
CONT/DIS, and PEST/DIS for further
information and required statements.
May be in metric as well as U.S. units
103
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6 162.10 Labeling requirement*.
(a) General—<1) Contents of the
label Every pesticide products shall
bear a label containing the informa-
tion specified by the Act and the regu-
lation* In this Part. The contents of a
label must show clearly and promi-
nently the following:
.tO The name, brand, or trademark
under which the product is sold as pre-
scribed in paragraph (b) of this sec-
tion;
(il) The name and address of the
producer, registrant, or person for
whom produced as prescribed in para-
graph (c) of this section:
(ill) The net contents as prescribed
in paragraph (d) of this section:
(iv) The product registration
number as prescribed in paragraph (e)
of this section:
104
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Environmental Protection Agency
§ 162.10
(v) The producing establishment
number as prescribed in paragraph (f)
of this section;
(vi) An ingredient statement as pre-
scribed in paragraph (g) of this sec-
tion;
(vii) Warning or precautionary state-
ments as prescribed in paragraph (h)
of this section;
(viii) The directions for use as pre-
scribed in paragraph (i) of this section;
and
(ix) The use classificaUon(s) as pre-
scribed In paragraph (J) of this section.
(2) Prominence and legibility. (i) All
words, statements, graphic representa-
tions, designs or other information re-
quired on the lihfltng by the Act or
the regulations in this part must be
clearly legible to a person with normal
vision, and must be placed with such
conspicuousness (as compared with
other words, statements. draJgna, or
graphic matter on the l»fr*l*"g) and
expressed in such terms as to render it
likely to be read and understood by
the ordinary individual under custom-
ary conditions of purchase and use.
(ii) All required label text must
(A) Be set in 6-point or larger type;
(B) Appear on a clear contrasting
background: and
>«» a
label can reasonably be expected to
remain affixed during the foreseeable
conditions and period of use. If the im-
mediate container Is enclosed within a
wrapper or outside container through
which the label cannot be clearly read.
the label must also be securely at-
tached to such outside wrapper or con-
tainer, if it is a part of the package as
customarily distributed or sold.
(ii) Tank cars and other bulk con-
tainers—y particular
including both pesticidal and non-pes-
ticidsJ claims. Examples of statements
or representations In the labeling
which constitute misoranoing include:
(i) A false or iP1*1*****"!1 statement
concerning the composition of the
P"^*4i* •*•
AwQliw**
(ii) A fajse or »"<«1«**<"ff statement
irning the effectiveness of the
product as a pesticide or device;
(Hi) A false or **m**Mnf statement
about the value of the product for
purposes other than as a pestidde or
device;
(iv) A false or tntelttadlng comparison
with other pesticides or devices;
(v) Any ftttfin~!* directly or indi-
rectly implying that the pesticide or
device Is rrmtmmnvfa^ or endorsed by
any agency of the Federal Govern-
ment;
(vi) The name of a pestidde which
contains two or more principal active
105
-------
§ 162.10
40 CFR Ch. I (7-145 Edition)
ingredients if the name suggests one
or more but not all such principal
active ingredients even though the
names of the other ingredients are
stated elsewhere in the labeling:
(vii) A true statement used in such a
way as to give a false or misleading im-
pression to the purchaser;
(viii) Label disclaimers which negate
or detract from labeling statements re-
quired under the Act and these regula-
tions;
(ix) Claims as to the safety of the
pesticide or its ingredients, including
statements such as "safe." "nonpoison-
ous," "noninjurious," "harmless" or
"nontoxic to^humans and pets" with
or without such a~ qualifying phrase as
"when used as directed"; and
(x) Non-numerical and/or compara-
tive statements on the safety of the
product, including but not limited to:
(A) "Contains all natural ingredi-
ents":
(B) "Among the least toxic chemi-
cals known"
(C) "Pollution approved"
(6) Final printed labeling. (1) Except
as provided in paragraph (aX6)(ii) of
this section, final printed labeling
must be submitted and accepted prior
to registration. However, final printed
labeling need not be submitted until
draft label texts have been provision-
ally accepted by the Agency.
(11) Clearly legible reproductions or
photo reductions will be accepted for
unusual lab??s such as these cili-
screened directly onto glass or metal
containers or large bag or drum labels.
Such reproductions must be of micro-
film reproduction quality.
(b) .Vanvs, brand, or trademark. (1)
The name, brand, or trademark: under
which the pesticide product Is sold
shall appear on the front panel of the
label
(2) No name, brand, or trademark
may appear on the label which:
(1) T* false or tn*flifting, or
(11) Has not been approved by the
Administrator through registration or
supplemental registration as an addi*
tional name pursuant to f 16&6CbX4).
(c) Name and address of producer,
registrant, or person for whom pro-
duced. An unqualified name and ad-
dress given on the label shall be con-
sidered as the name and address of the
producer. If the registrant's name ap-
pears on the label and the registrant is
not the producer, or if the name of the
person for whom the pesticide was
produced appears on the label, it must
be qualified by appropriate wording
such as "Packed for • • •." "Distribut-
ed by • V or "Sold by to show
that the name is not that of the pro-
ducer.
(d) Net weight or measure of con-
tents. (1) The net weight or measure
of content shall be exclusive of wrap-
pers or other materials and shall be
the average content unless explicitly
stated as a minimum quantity.
(2) If the pesticide is a liquid, the
net content statement shall be in
terms of liquid measure at 68* F (20*C),
and shall be expressed in conventional
American units of fluid ounces, pints.
quarts, and gallons.
(3) If the pesticide is solid or semi-
solid, viscous or pressurized, or is a
mixture of liquid and solid, the net
content statement shall be In terms of
weight expressed as avoirdupois
pounds and ounces.
(4) In all cases, net content shall be
stated in terms of the largest suitable
units. Le.. "1 pound 10 ounces" rather
than "26 ounces."
(5) In addition to the required units
specified, net content may be ex-
pressed in metric units.
(6) Variation above minimum con-
tent or around an averse is pers*isji-
ble only to the extent that It repre-
sents deviation unavoidable in good
"^•*vifafffoir*ng practice. Variation
below a stated minimum is not permit-
ted. In no case shalkthe average con-
tent of the packages in a shipment fall
below ^h** stated average content.
(e) Product registration number.
The registration number assigned to
the pesticide product at the time of
registration shall appear on the label.
preceded by the phrase "EPA Regis-
tration NoV or the phrase "EPA Re*.
No." The mglstrafJno number shall be
set in type of a ate and style similar to
other print on that part of the label
on which It appears and shsU run par-
allel to it The registration number
and the required identifying phrase
shall not appear In such a «••»••«** as
to suggest or Imply recommendation
106
-------
Environmental Protection Agoncy
or endorsement of the product by the
Agency.
-------
§ 162.10
40 CFR Ch. I (7-1-85 Edition)
(h) Warnings and precautionary
statements. Required warnings and
precautionary statements concerning
the general areas of toxicological
hazard including hazard to children.
environmental hazard.'and physical or
chemical hazard fall into two groups;
those required on the front panel of
the labeling and those which may
appear elsewhere. Specific require-
ments concerning content, placement.
type size, and prominence are given
below.
(1) Required front panel statements.
With the exception of the child
hazard warning statement, the text re-
quired on the front panel of the label
Is determined by the Toxicity Catego-
ry of the pesticide. The category is as-
signed on the basis of the highest
hazard shown by any of the indicators
in the table below:
Heart
•tago
I
IV
Or*U>_.
Up «o and Muting SO
mo/**
end Mkxfcig .2
Fiwn 90 twj 900
Up to «* Mw*^ 200
«8^»
Figm 200 Mi 2000
SUn<
pmMng tor 7 *y».
[72
From 500 tra MOO
<«•
From 2, tm 20 mg/Nir-
From 2400 fmi 20.000.-
No
•ITS
ton.
fwiSOOOmg/
^
ton 20 me/tor.
ton 20400.
NoMaton.
MM or light HMbn «
72 tan.
(t) Hitman hazard signal word— (.A)
Toxicity Category L All pesticide prod-
ucts meeting the criteria of Toxidty
Category I shall bear on the front
panel the signal word "Danger." In ad-
dition If the product was assigned to
Toxidty Category I on the basis of ita
oral. Inhalation or dermal tozldty (as
distinct from akin and eye local ef-
fects) the word "Poison" shall appear
in red on a background of distinctly
contrasting coloi und the skull and
crossbones shall appear in *****•****+
proximity to the word "'poison."
(B) Toxidty Category IL An pesti-
dde product! meeting the criteria of
Toxidty Category n loan bear on the
front panel the slcnal word "Warn-
(C) Toxtdtv Category OL AH peed-
dde prodneti nunfliu the criteria of
Toxidty Category m shan bear on
the front panel the signal word *Can-
0» TastcU* CaUeont IV. AH pestf-
dde products meeting the criteria of
Toxidty Catecory 17 shan bear on the
that such libeling is necessary to pre-
vent unreasonable adverse effects on
man or the environment. In no ease
shall more than one human hazard
signal word appear on the front panel
of a label
(11) Child hazard warning. Every pes-
ticide product label shall bear on the
front panel the statement "keep out of
reach of children." Only in cases
where the likelihood of contact with
children during distribution, marfc^w-
ing. storage or use is demonstrated by
applicant to be f^li *iM*^y remote,
or if the nature of the pesticide is such
that it is approved for-use on infants
f nti
tor waive this
(Hi)
-------
Environmental Protection Agency
§ 162.10
front panel near the word "Poison"
and the skull and crossbones.
(B) Other toxicity categories. The
statement of practical treatment is not
required on the front panel except as
described in paragraph (hXIXiiiXA) of
this section. The applicant may. how-
ever, include such a front panel state-
ment at his option. Statements of
practical treatment are. however, re-
quired elsewhere on the label in
accord with paragraph (hX2) of this
section if they do not appear on the
front paneL
(iv) Placement and prominence. All
the require front panel warning state-
ments shall 51 grouped together on
the label, and thall appear with suffi-
cient prominence relative to other
front panel text and graphic material
to make them unlikely to be over-
looked under customary conditions of
purchase and use. The following table
shows the minimum type size require-
ments for the front panel warning
statements on various sizes of labels:
So* at lab* trot* panel in squOT
inchM
i**ov« 5 to ">
*4w— r «0 «o '5
A*P^ <5 *if ?0
Ot_ 1ft
Pomti
RaqurwJ
•gnat
•OHt*
eapftars
0
10
12
14
16
-KMpOUl
of r«actro<
cfcrfdrarT
6
6
6
10
12
(2) Other required warnings and pre-
cautionary statements. The warnings
and precautionary statements as re-
quired below shall appear together on
the label under the general heading
"Precautionary Statements" and
under appropriate subheadings o'f-
"Hazard to Humans and Domestic Ani-
mals." "Environmental Hazard" and
"Physical or Chemical Hazard."
(i) Hazard to humans and domestic
animals. (A) Where a hazard exists to
humans or domestic *n»m«r
-------
§ 162.10
40 O=R Ch. I (7-1 -85 Edition)
stances under which they are required
follow:
(A) If a pesticide intended for put-
door use contains an active ingredient
with a mammalian acute oral LDM of
100 or less, the statement "This Pesti-
cide is Toxic to Wildlife" is required.
(B) If a pesticide intended for out-
door use contains an active ingredient
with a fish acute LC*. of 1 ppm or less.
the statement "This Pesticide is Toxic
to Pish" is required.
(C) If a pesticide Intended for out-
door use contains an active ingredient
with an avlan acute oral LDM of 100
nag/kg or less, or a cubacute dietary
LC,. of 500 ppm or less, the statement
"This Pesticide is Toxic to Wildlife" is
required. -T
(D) If either accident history or field
studies demonstrate that use of the
pesticide may result in fatality to
birds, fish or mammals, the statement
"This pesticide is extremely toxic to
wildlife (fish)" is required.
(E) For uses involving foliar applica-
tion to agricultural crops, forests, or
shade trees, or for mosquito abate-
ment treatments, pesticides toxic to
pollinating insects must bear appropri-
ate label cautions.
(F) For all outdoor uses other than
aquatic applications the label must
bear the caution "Keep out of lakes.
ponds or streams. Do hot contaminate
water b'y cleaning of equipment or dis-
posal of wastes."
(iii) Physical or chemical hazards.
Warning statements on the flammabil-
ity or explosive characteristics of the
pesticide are required as follows:
RaahpoM
Required tart
(A)
COflV
poM at or Mow gr f-.t turn it •
20*Fandnoto*arKrForl(
la mora than IS in long at a 'J
Raan
any
Ftaah point
tama
ol 6 to from
Alotnar praai
or IneinanM
130* F may cama
and naatad aurfacaa. Oo not
to tamparaturaa
bunting.
Flammabla. Contents undar praaaura. Kaap away trom haat.
•pants, and opan tama. Do not punetura or tndnarata oontainar.
Gvpoaura to temparaturaa abova UO f may causa bunrtng.
Contents undar praaaura. Do not uaa or Mora naar haat or ican
iama. Do not punctura or ranartu oontainar. EJO^OSUV to
tamparaturaa abo»a 130* F may cauia bunting.
(8)
At or batow 20* F.
AAosw 20* F and not ow M* f.
•.-? - «••' ? wid not ov«, SO'F.
Extramafy flammabto. Kaap away Irom flra. aparks. and haaiad
nammabta. Kaap away from haat and opan tama.
Oo not uaa or atom naar haat or opan flama.
(i) Directions for U*e— <1) General
requircmer^a—m Adequacy and clar-
ity of direction*. Direction* for use
must be stated in terms which etn be
easily read and understood by the av-
enge penoo likely to use or to super-
vise the use of the pesddde. When fol-
lowed, direction* must be adequate to
protect the public from fraud and
from personal injury and to prevent
unreasonable advene effects on the
(li)
far use
of the label provided that they are
conspicuous enough to be easily read
by the user of the pesticide product.
Directions for use may appear on
printed or graphic matter which ac-
companies the pesticide provided that:
(A) If required by the Agency, such
printed or graphic matter Is securely
attached to each package of the pesti-
cide, or placed within the outside
wrapper or bag-
(B) The label bears a reference to
tft^ directions for use In *m*v****[>***• y^g
leaflets or circulars, such as "See di-
rections in the enclosed circular" and
CO The Administrator ifii
that it is not necessary for such direc-
tions to appear on the labeL
(111) Exception* to requirement for
direction for Kse-CA) Detailed direc-
tions for use may be omitted from la-
beling of pesticides which are intended
110
-------
Environmental Protection Agency
§ 162.10
for use only by manufacturers of prod-
ucts other than pesticide products in
their regular manufacturing processes.
provided that:.
(/) The label clearly shows that the
product is intended for use only in
manufacturing processes and specifies
the type
-------
§ 162.11
(E) For restricted use pesticides, a
statement that the pesticide may be
applied under the direct supervision of
a certified applicator who is not phys-
ically present at the site of application
but nonetheless available to the
person applying the pesticide, unless
the Agency has determined that the
pesticide may only be applied under
the direct supervision of a certified ap-
plicator who is physically present.
(F) Other pertinent information
which the Administrator determines
to be necessary for the protection of
man and the environment.
(j) Statement of Use Classification.
By October 22. 1976. all pesticide prod-
ucts must bear on their labels a state-
ment of use dissilicaUon as described
in paragraphs (J) (1) and (2) of this
section. Any pesticide product for
which some uses are classified for gen-
eral use and others for restricted use
shall be separately labeled according
to the l^^ltng standards set forth in
this subsection, and shall be marketed
as separate products . with differen-
registration numbers, one bearing di-
rections only for general use(s) and
the other bearing directions for re-
stricted use
-------
Criteria
PHYS/CHEM-1
PHYSICAL/CHEMICAL HAZARDS
Required Label Statement
I. Pressurized Containers
A. Flashpoint at or below
20°F; or if there is a
flashback at any valve
opening.
B. Flashpoint above 20°F
and not over 80°F; or
if the flame extension
is more than 18 inches
long at a distance of
6 inches from the
valve opening.
C. All Other Pressurized
Containers
II. Non-Pressurized Containers
A. Flashpoint at or below
20°P.
B. Flashpoint above 20*F
and not over 80°F.
C. Flashpoint over 80°F
and not over 150°F.
D. Flashpoint above
150°F.
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame. Do
not puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or _store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
113
-------
STOR-1
STORAGE INSTRUCTIONS FOR PESTICIDES
Heading;
All products are required to bear specific label instructions
about storage and disposal. Storage and disposal instructions
must be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need not include the heading
"STORAGE AND DISPOSAL."
Storage Instructions;
All product labels are required to have appropriate storage
instructions. Specific storage instructions are not prescribed.
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors;
1. Conditions of storage that might alter the composition or
usefulness of the pesticide. Examples could be temperature
extremes, excessive moisture or humidity, heat, sunlight,
friction, or contaminating substances or media.
2. Physical requirements of storage which might adversely
affect the container of the product and its ability to
continue to function properly. Requirements might include
positioning of the container in storage, storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
3. Specifications for handling the pesticide container,
including movement of container within the storage area,
proper opening and closing procedures (particularly for
opened containers), and measures to minimize exposure
while opening or closing container.
4. instructions on what to do if the container is damaged in
any way, or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs.
5. General precautions concerning locked storage, storage in
original container only, and separation of pesticides
during storage to prevent cross-contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original pontainer and placement in
locked storage areas.
114
-------
PEST/DIS-1
PESTICIDE DISPOSAL INSTRUCTIONS
The label of all products, except those intended solely for domestic
use, must bear explicit instructions about pesticide disposal. The
statements listed below contain the exact wording that must appear on
the label of these products:
1. The labels of all products, except domestic use, must contain the
statement, "Do not contaminate water, food, or feed by storage or disposa
2. Except those products intended solely for domestic use, the labels
of all products that contain active ingredients that are Acute Hazardous
Wastes (see list in this Appendix) or are assigned to Toxicity Category
I on the basis of oral or dermal toxicity, skin or eye irritation potent!
or Toxicity Category I or II on the basis of acute inhalation toxicity
must bear the following pesticide disposal statement:
"Pesticide wastes are acutely hazardous. Improper disposal of
excess pesticide, spray mixture, or rinsate is a violation of Federal
Law. If these wastes cannot be disposed of by use according to
label instructions, contact your State Pesticide or Environmental
Control Agency, or the Hazardous Waste representative at the nearest
EPA Regional Office for guidance."
3. The labels of all products, except those intended for domestic use,
containing active or inert ingredients that are Toxic Hazardous Wastes
(see list in this Appendix) or meet any of the criteria in 40 CFR 261,
Subpart C for a hazardous waste must bear the following pesticide disposa
statement:
"Pesticide wastes are toxic. Improper disposal of excess pesticide,
spray mixture, or rinsate is a violation of Federal Law. If these
wastes cannot be disposed of by use according to label instructions,
contact your State Pesticide or Environmental Control Agency, or the
Hazardous Waste representative at the nearest EPA Regional office
for guidance."
4. Labels for all other products, except those intended for domestic
use, must bear the following pesticide disposal statement:
"Wastes resulting from the use of this product may be disposed of on
site or at an approved waste disposal facility."
5. Products intended for domestic use only must bear the following
disposal statement: "Securely wrap original container in several layers
of newspaper and discard in trash.
"
115
-------
PEST/DIS-2
PESTICIDE ACTIVE INGREDIENTS THAT ARE ACUTE HAZARDOUS WASTES
I. PESTICIDES ON THE "E" LIST (with RCRA * and CAS #
[40 CFR 261.33(e)]
Ac role in
Aldicarb
Aldrin
Allyl alcohol
Aluminum phosphide
4-Aminopyridine (Avitrol)
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p-Chloroaniline
Cyanides (soluble cyanide salts
not otherwise specified)
Cyanogen chloride
Dieldrin
0,0-Diethyl S-[2-ethylthio)ethyll
phosphorodithioate (disulfoton)
0,O-Diethyl 0-pyrazinyl
phosphorothioate (Zinophos*)
Dimethoate
O,O-Dimethyl O-p-nitrophenyl
phosphorothioate (methyl parathion)
4,6-Dinitro-o-cresol and salts
4,6-Dinitro-o-cyclohexylphenol
Dinoseb
Endosulfan
Endothall
Endrin
Famphur
Fluoroacetamide
Heptachlor
He xachlorohexahydro-exo,e xo-
dimethanonaphthalene (Isodrin)
Hydrocyanic acid
Methomy1
alpha-Naphthylthiourea (ANTU)
Nicotine and salts
Octamethylpyrophosphoranft.de
(OMPA, schradan)
Parathion
Phenylmercuric acetate (PMA)
Phorate
Potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
P003 107-13-1
P070 llf-OP-3
P004 309-00-2
POOS 107-18-6
P006 1302-45-0
POOS 504-24-5
P010 7778-39-4
P011 1303-28-2
P012 1327-53-3
P021 592-01-8
P022 75-15-0
P024 106-47-8'
P030
P031 506-77-4
P037 60-57-1
P039 298-04-4
P040 297-97-2
P044
P071
P047
P034
P020
P050
P088
P051
P097
P057
P059
P069
P063
P066
P072
P075
P085
P08«U
P092
P094
P098
P102
P105
P106
P058
60-51-5
298-00-0
534-52-1
131-89-5
88-85-7
115-29-7
129-67-9
72-20-8
52-85-7
640-19-7
76-48-8
465-73-6
74-90-8
16752-77-5
86-88-41
54-11-5
152-16-9
56-38-2
62-38-4
298-02-2
151-50-8
107-19-7
26628-22-8
143-33-9
62-74-8
116
-------
PEST/DIS-3
Strychnine and salts PlOft
O,O,0,O-Tetraethyl . P109
dithiopyrophosphate (sulfotepp)
Tetraethyl pyrophosphate Pill
Thallium sulfate P115
Thiofanox P045
Toxaphene P123
Warfarin (>0.3%) P001
Zinc phosphide (>10%) P122
57-24-9
60-41-3
3689-24-5
107-49-3
7446-18-6
39196-18-4
8001-35-2
81-81-2
1314-84-7
50 ACTIVES
II. PESTICIDES DERIVED FROM
[40 CFR 261.31]
TRI-, TETRA-, AND PENTACHLOPOPHENOLS
2-Ohloroethyl 2-( 2, 4 ,6-trichloro-
phenoxy) Pthyl ether
De hyd roa bi e t y 1 ammon i um
pentachlorophenoxide
Er bon
0-ethyl O-( 2,4 ,5-t rich lorophenyl)
ethylphosphonothioate
2, 2'-Methylenebis
(3/4 , 6-trichlorophenol)
( Hexachlorophene)
--Potassium salt of
— Sodium salt of
--Disodium salt of
Pentachlorophenol
— Potassium salt of
--Sodium salt of
--Zinc salt of
--Zinc -salt of N-alkyl
--Pentachlorophenyl laurate
Potassium trichlorophenate (2,4,6)
Potassium trichlorophenate (2,4,5)
Silvex
--2-Butoxyethyl ester
--Butoxypolypropoxypropyl ester
--Butoxypropyl ester
--Diethanolamine salt
--Di isopropanolamine salt
--Dimethylamine salt
--Dipropylene glycol isobutyl
ether ester
--Ethanolamine salt
— 2-Ethylhexyl ester
--Isooctyl ester
F027 5324-22-1
F027 35109-57-0
F027 136-25-4
F027 327-98-0
F027 70-30-4
F027 67923-62-0
F027 3247-34-5
F027 5736-15-2
F027 87-86-5
F027 7778-73-6
F027 131-52-2
F027 2917-32-0
F027
F027 3772-94-9
F027 2591-21-1
F027 35471-43-3
F027 93-72-1
F027 19398-13-1
F027 53404-07-2
F027 25537-26-2
F027 51170-59-3
F027 53404-09-4
F027 55617-85-1
F027 53535-26-5
F027 7374-47-2
F027 53404-76-5
F027 53404-14-1
117
-------
PEST/DIS-4
--Isopropanolamine salt
—Monohydroxylaluminum salt
--Polypropoxypropyl ester
--Potassium salt
--Propylene glycol isobutyl
ether ester
--Sodium salt
--Triethanolamine salt
--Triethylamine salt
--Triisopropanolamine salt
--Tripropylene glycol isobutyl
ether ester
Sodium 2-(2,4,5-trichlorophenoxy)
ethyl sulfate
Tetrachlorophenols
--ALkylamine*amine salt (as in
fatty acids of coconut oil)
--Potassium salt
--Sodium salt
2,4,5-Trichlorophenol
2, 4,6-Trichlorophenol
2,4,5-Trichlorophenol salt of
2,6-bisf(dimethylami no)methyl]
cyclohexanone
2,4,5-Trichlorophenol, sodium salt
2,4,6-Trichlorophenol, sodium salt
2,4,5-TrichlorophenoxyacetLc acid
--Alkyl C-12 amine salt
--Alkyl C-13 amine salt
--Alkyl C-14 amine salt
--N,N-d.iethylethanolamine salt
--Dimethylamine salt
--N,N-dimethyllinoleylamine salt
--N,N-dimethyloleylamine salt
--N-oleyl-lf3-propylene
diamine salt
--Sodium salt
--Triethanolamine salt
--Triethylamine salt
—Alkyl (C3H7 - C7H9) ester
--Amyl ester
--Butoxyethoxypropyl ester
--2-Butoxyethyl ester
--Butoxypropyl ester
--Butyl ester
--Dipropylene glycol isobutyl
ether ester
--2-Ethylhexyl ester
--Isobutyl ester
F027 53404-13-0
F027 69622-82-8
F027 83562-66-7
F027 2818-16-8
F027 53466-84-5
F027 37913-89-6
F.027 17369-89-0
F027 53404-74-3
F027 53404-75-4
F027 53535-30-1
F027 3570-61-4
F027 25167-83-3
F027
F027 53535-27-6
F027 25567-55-9
F027 95-95-4
F027 88-06-2
F027 53404-83-4
F027 136-32-3
F027 3784-03-0
F027 93-79-8
F027 53404-84-5
F027 53404-85-6
F027 53535-37-8
F027 53404-86-7
F027 6369-97-7
F027 53404-88-9
F027 53404-8<»-0
F027 53404-87-8
F027 13560-99-1
F027 3813-14-7
F027 2008-46-0
F027
F027 120-39-8
F027 1928-58-1
F027 2545-59-7
F027 1928-48-9
F027 93-79-8
F027 53535-31-2
F027 1928-47-8
F027 4938-72-1
118
-------
PEST/DIS-5
--Isopropyl ester F027 93-78-7
--Propylerse glycol isobutyl F027 53466-86-7
ether ester
--Tripropylene glycol isobutyl F027 53535-32-3
ether ester
4-(2,4,5-Trichlorophenoxy)butyric F027 93-80-1
acid [2,4,5-TB]
2-(2,4,5-Trichlorophenoxy)ethyl F027 69633-04-1
hydrogen sulfate [2,4,5-TES]
1,4',5'-Trichloro-2I-(2,4f5- F027 69462-14-2
trichlorophenoxy)
methanesulfonanilide [Edolan U]
119
-------
PEST/DIS-6
PESTICIDES THAT ARE TOXIC HAZARDOUS WASTES
PESTICIDES ON THE " F" LIST (with
[40 CFR 261.33(f) ]
Acetone
Acrylonitri le*
Am it role
Benzene*
Ris( 2-ethylhexyl}phthalate
Cacodylic acid
Carbon tetrachloride*
Chloral (hydrate)
(chloroacet aldehyde)
Chlordane, technical*
Chloro benzene*
4-Chloro-m-cresol
Chloroform*
o-Ch loropheno 1
Creosote
Cresylic acid (cresols)*
Cyclohexane
Cyc lohexanone
Decachlorooctahydro-1 , 3 , 4-metheno-
2H-cyc lobuta[c,d] -pentalen-2-one
(Kepone, chlordecone)
1 , 2 -Di bromo- 3-c h loropropacte ( DBCP )
Dibutyl phthalate
S-2, 3-( Dichloroallyl diisopropyl-
thiocarbamate) (diallate,Avadex)
o-Di chloro benzene*
p-Dichloro benzene*
Di ch lorod i f luorome thane
(Freon 12*)
3,5-Dichloro-N-( l,l-dimethyl-2-
propynyl) benzamide
(pronamide, Kerb^)
Dichloro diphenyl dichloroethane
(ODD)
Dichloro diphenyl trichloroethane
(DDT)
Dichloroethyl ether
2 , 4 -Dich loropheno xyace t i c ,
salts and esters (2,4-D)*
1 , 2-Dichloropropane
1 , 3-Dichloropropene (Telone)
Dimethyl phthalate
Epichlorohydrin
( l-chloro-2,3-epoxypropane)
Ethyl acetate
Ethyl 4 ,4'-dichlorobenzilate
(chlorobenzilate)
RCRA t,
U002
U009
U011
U019
U028
U136
U211
U034
U036
U037
U039
U044
U048
U051
U052
U056
U057
U142
U066
U069
U062
U070
U072
U075
U192
U060
U061
U025
U240
U083
U084
U102
U041
U112
U038
_ *
and CAS t
67-64-1
107-13-1
61-82-5
71-43-2
117-81-7
75-60-5
56-23-5
302-17-0 ,
57-74-9
108-90-7
59-50-7
67-66-3
95-57-8
8021-39-4
1319-77-3
110-82-7
108-94-1
143-50-0
96-12-8
84-74-2
2303-16-4
95-50-1
106-46-7
75-71-8
23950-58-5
72-54-8
50-29-3
1191-17-9
94-75-7
8003-19-8
542-75-6
131-11-3
106-89-8
141-78-6
510-15-6
•Proposed for deletion by TCLP proposal
120
-------
PEST/DIS-7
Ethylene dibromide (EDB)
Ethylene dichloride*
Ethylene oxide
Formaldehyde
Furfural
Hexachlorobenzene*
Hexachlorocyclopentadiene
Hexachloroethane*
Hydrofluoric acid
Isobutyl alcohol*
Lead acetate
Lindane*
Maleic hydrazide
Mercury
Methoxychlor*
Methyl alcohol (methanol)
Methyl bromide
Methyl chloride
2,2'-Methylenebis
(3,4,6-trichlorophenol)
(hexachlorophene)
[acute waste per 261.31]
Methylene chloride*
Methyl ethyl ketone*
4-Methyl-2-pentanone
(methyl isobutyl ketone)
Naphthalene
Nitrobenzene*
p-Nitrophenol
Pentachloroethane
Pentachloronitrobenzene (PCNB)
Pentachloropheno1*
[acute waste per 261.31]
Phenol*
Pyridine*
Resorcinol
Saf-role
Selenium disulfide
Rilvex [acute waste per 261.31]
1,1,2,2-Tetrachloroethane*
Tetrachloroethylene*
2,3,4,6-Tetrachlorophenol*
[acute waste per 261.31]
Thiram
•Toluene*
1,1,1-Trichloroethane*
(methyl chloroform)
Trichloroethylene*
Trichloromonofluoromethane
(Freon 11«)
2,4,5-Trichlorophenol*
[acute waste per 261.31]
2,4,6-Tr i chloropheno1*
[acute waste per 261.31]
U067
U077
U115
U122
U125
U127
U130
U131
U134
U140
U144
U129
U148
U151
U247
U154
U029
U045
U132
106-93-4
107-06-2
75-21-8
50-00-0
98-01-1
118-74-1
77-47-4
67-72-1
7664-39-3
78-83-1
301-04-2
58-89-9
123-33-1
7439-97-6
72-43-5
67-56-1
74-83-9
74-87-3
70-30-4
unso
U159
U161
U165
U169
U170
U184
U185
U242
U188
U196
U201
U203
U205
U233
U209
U210
U212
U244
U220
U226
U228
U121
U230
U231
75-09-2
78-93-3
108-10-1
91-20-3
98-95-3
100-02-7
76-01-7
82-68-8
87-86-5
108-95-2
110-86-1
108-46-3
94-59-7
7488-56-4
93-72-1
79-34-5
127-18-4
137-26-8
108-88-3
71-55-6
79-01-6
75-69-4
95-95-4
88-06-2
121
-------
PEST/DIS-8
2,4,5-Trichlorophenoxyacetic acid U232 93-76-5
(2,4,5-T)*
[acute waste per 261.31]
Warfarin «0.3%) U248 81-81-2
Xylene U239 1330-20-7
Zinc phosphide (<10%) U249 1314-84-7
8'3 ACTIVES
122
-------
CONT/DIS-1
CONTAINER DISPOSAL INSTRUCTIONS
The label of each product must bear container disposal
instructions appropriate to the type of container.
1. Domestic use products must bear one of the following
container disposal statements:
Container Type
Statement
Non-aerosol products
(bottles, cans, jars)
Non-aerosol products
( bags )
Aerosol products
Do not reuse container (bottle, can, jar).
Rinse thoroughly before discarding in trash.
Do no't reuse bag. Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or puncture.
2. All other products must bear container disposal instructions,
based on container type, listed below:
Container Type
Statement
Metal
containers
(non-aerosol)
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or by
other procedures approved by state and local
authorities.
Plastic containers
Triple rinse (or equivalent).Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or
incineration, or, if allowed by state and
local authorities, by burning. If burned,
stay out of smoke.
Glass containers
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved state and local procedures.
Fiber drums
with liners
Completely empty liner by shaking and
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
Paper and
plastic bags
Compressed gas
cylinders
reused1, dispose of in the same manner.
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out of smoke.
Return empty cylinder for reuse (or
similar wording)
£/ Manufacturer may replace this phrase with one indicating
whether and how fiber drum may be reused.
123
-------
III. EPA INDEX TO PESTICIDE CHEMICALS
index to Pesticide Chemicals - Pentachloronitrobenzene
124
-------
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
TABLE OF CONTENTS
Site Name
TERRESTRIAL FOOD CROP
(Agricultural Crops)
Barley (seed)
Beans (dry)
Beans (green)
Beans (kidney)
Beans (lima)
Beans (seed)
Beans (snap)
Broccoli
Brussels Sprouts
Cabbage
Cauliflower
Corn (seed)
Cotton (acid delinted seed)
Cotton (fuzzy seed)
Cotton (reginned or mechanically delinted seed)
Cotton (seed)
Garlic (cloves)
Garlic ("seed" cloves)
Oats (seed)
Peanuts (seed)
Peas (seed)
Peppers
Potatoes (seed piece)
Rice (seed)
Saf flower (seed)
Sorghum (seed)
Soybeans (seed)
Sugar Beets (seed)
Tomatoes (bed grown)
Wheat (seed)
Page
2
2
2
2
3
3
3
2
3
2
3
4
5
4
5
4
5
5
6
9
10
10
6
11
11
11
12
13
14
14
15
15
16
16
13
14
16
14
17
TERRESTRIAL NON-FOOD CROP 18
(Ornamentals Plants ano Forest Trees)
African Violet "" 18
Azalea 18
Bedding Planes 18
Begonia 18
Calendula 19
Issued: 10-31-85 II-056502-i
125
-------
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
TABLE OF CONTENTS
Site Name Page
Camellia 19
Carnation 18
Chrysanthemum 18
Gladiolus 20
Hyacinth 20
Iris (bulbous) 20
Iris (Dutch) 22
Larkspur 19
Lilies (Easter) 21
Narcissus 20
Ornamental Flowering Plants 22
Ornamental Woody Shrubs 22
Pine (Southern-) (seedlings) 23
Poinsettia 18
Roses 23
Snapdragon 18
19
Southern Magnolia 23
Sweet Peas 19
Tulips 20
(Ornamental Lawns and Turf (including ground covers)) 24
Bahiagrass 24
25
Bentgrass 26
27
30
Bennudagrass 25
26
29
31
Bluegrass 24
27
2V
30
Centipedegrass 24
25
Dichondra 32
Fescue 24
29
Fescue (fine) 27
30
Fescue (fine leaf) 27
Kentucky Bluegrass 24
26
Kentucky Bluegrass (Marion and Windsor varieties) 28
Ornamental Lawns 29
30
Issued: 10-31-85 II-056502-ii
126
-------
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
TABLE OF CONTENTS
Site Name
Ornamental Lawns (cool season)
Ornamental Lawns (cool season) (bluegrass)
Ornamental Lawns (warm season)
Ornamental Turf
Ornamental Turf (golf fairways)
Ornamental Turf (golf tees)
Ornamental Turf (lawns)
Ornamental Turf (putting greens)
Ryegrass
Ryegrass (perennial)
St. Augustinegrass
Tall Fescue
Page
27
28
30
28
24
25
31
29
30
27
27
30
27
29
30
24
27
24
25
2b
2e
30
31
2<4
25
Issued: 10-31-85
II-056502-iii
127
-------
EPA Index to Pesticide Chemicals
C056502 ' PENTACHLORON1TROBENZENE*
TYPE PESTICIDE: Fungicide
FORMULATIONS:
Tech (94%, 952, 96%, 97%)
FI (80%, 90%)
D (10%, 20%, 25%, 30%, 40%)
G (2%, 2.25%, 2.5%, 3.75%, 4.67*. 5%, 6.5%, 9.95%, 10%, 12.5%, 13.57%,
15.4%, 16.9%, 302)
WP (14%, 30%, 35%, 75%)
EC (12.5%, 22.9%, 23.2%, 23.4%, 23.8%, 23.9Z, 24%, 24.7Z, 26.49%)
F1C (17%)
RTU (10Z, 17.68%, 20%, 22.6%, 23.1Z, 23.2%, 23.7%, 24%, 25Z)
GENERAL WARNINGS AND LIMITATIONS: The following proteccive clothing are
required during mixing/loading operations: gloves, long-sleeved shirt,
long pants, socks and shoes. Do not plant any root crops not registered
for Pentachloronitrobenzene (PCNB) in rotation on PCNB treated soil. Do
not feed or graze treated foliage. Do not use treated seed for food, feed
or oil purposes. Do not feed cotton gin waste to livestock. Do not allow
hogging down of peanuts. Consult State Agricultural Extension Service for
additional information, as the timing, number, and rate of applications
needed will vary with local conditions. Dosage rates are given in active
ingredient.
Definition of terms:
Tablespoons (this)/teaspoons (tsp) actual: A hypothetical quantity com-
puted by multiplying the number (or equivalent number) of tablespoons or
teaspoons of product by the concentration (percentage) of active ingredi-
ent in the formulation.
Agricultural Crop Tolerances (other than those listed in the report):
Interim tolerances: 0.1 ppm on bananas
Agricultural Seed Treatments: The Federal Seed Act requires that seed
treated with a pesticide must contain a dye whicn imparts an unnatural
color to the seed if the seed is intended to be moved in interstate com-
merce. Apply dust formulations in planter box.
*PCNB
Terraclor
Issued: 10-31-85 11-056502-1
128
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Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulation(s)
/08063AA
FLAEUAL
TERRESTRIAL FOOD CROP
(Agricultural crops)
Barley (seed)
Covered smut
(Ustilago)
/15003AA
/15001AA
FHANSAQ
Beans (snap)
Beans (dry)
White mold
(Sclerotinia)
/28001AA
FKACFAK
FKAGRAM
FKAGPES
Beans (seed)
Fusariun
Rhizoctonia
Pythium
0.03-0.064
Ib/bu
(202, 252 D)
(23.2-252 EC)
(23.1-23.72)
RTU)
or
0.039-0.136
lb/100 Ib
(172 FLO
(17.68% RTU)
(2.23 Ib/gal
or 242 RTU)
(1.72-1.8
Ib/gal or
202 RTU)
N.F.
Seed treatment. Apply as a dry mix
or as a slurry or liquid, mixed at
recommended dilutions. Use appro-
priate slurry or liquid treating e-
quipment.
May be formulated with lindane;5-
ethoxy-3-(trichloromethyl)-l,2,4-thia
diazole; xylene; or carboxin.
2.0-2.06
lb/8-10
gal/A
(14,500 ft of
row (bush)
or 8,430 ft
of row
(pole)]
(75* WP/D)
(2 Ib/gal
or
23.82-242
EC)
0.053 lb/100
Ib
(1.8 Ib/gal
or 202 RTU)
0.1 ppm (interim)
0.1 ppm (interim)
Apply a maximun of 7.5 pounds per
acre per season. Soil application
Row treatment. Apply as a spray in
8 inch band centered on row immedia-
tely after or at time of seeding.
If disease is severe, repeat appli-
cation at 2 to 3 week intervals.
Use 1 or 2 nozzles per row, direct-
ing spray at base of plant. Do not
apply after first bloom. Soil
should remain undisturbed after
treatment. Avoid applying directly
to seed as delayed emergence may oc-
cur.
0.1 ppm (interim)
Seed treatment. Apply product un-
diluted to seed or dilute 5 parts
product to 1 part water. Use appro-
priate liquid or slurry treating e-
quipment.
Formulated with 5-ethoxy3-(trichlor-
omethyD-1,2,4 thiadiazole.
Issued: 10-31-85
11-056502-2
129
-------
/28001AA
FKAGRAM
FKAGPES
FKAGFAK
FKAGTAK
/15002AA
/15001AA
FICBRAM
FICHPES
/15003AA
/15002AA
/15003AA
FKAGRAM
Site and Pest
Beans (seed)
Rhizoctonia
Pythium
Fusarium
Thielaviopsis
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Forraulation(s)
0.025-0.04
Ib/bu
(20°; D)
(24.7% EC)
(23.1-23.2%
RTU)
Beans (lima)
Beans (kidney)
Root rot 1.0-1.5 Ib/A
(Rhizoctonia) (102 G)
Stem roc
(Phythium)
Beans (green)
Beans (1ima)
Beans (snap)
Rhizoctonia solani 0.65-0.975
Ib/A
(6.5% G)
0.1 ppm (interim)
Planter-box seed treatment. Premix
with seed at specified rates direct-
ly in planter-box at planting time
or use other suitable premix equip-
ment. The ready-to-use formulation
may be applied undiluted to seed or
mixed with one part product to 2
parts water as required for seed
coverage.
May be formulated with 5-ethoxy-3-
trichloromethyl)-l,2,4-thiadiazole.
0.1 ppm (interim)
0.1 ppm (interim)
Soil application. Row treatment.
Apply at planting time. Use planter
and mixer attachment. Use appropri-
ate calibrations for seeding rates.
Hay be formulated with and captan.
0.1 ppm (interim)
0.1 ppm (interim)
0.1 ppm (interim)
Soil application. Row treatment.
Apply at planting time as a side
dress on each side of row. Do not
apply directly on seed. Do not ap-
ply more than once per season.
Plant injury may occur under such
conditions as extremely cool, wet
or extremely dry weather, or if
product is applied with certain pre-
emergent herbicides.
Formulated with 0,0-diethyl S-(2-
(ethyIthio)ethyl) phosphorodithio-
ate.
Issued: 10-31-85
II-056502-3
130
-------
Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulation(s)
Beans (green) cluster (continued)
FICBRAM
FICHRAM
Root rot
(Rhizoctonia)
Stem rot
(Rhizoctonia)
/13005AA
/13006AA
/13007AA
FEACPCU
Broccoli
Brussels Sprouts
Cabbage
Club root
(Plasmodiophora)
FIAGCEF
Wire stem or
Black root
(Corticium)
0.75-2.0 Ib/A
(14,500 ft of
row (bush),
or b,4iJO ft
of row
(pole)]
(102 G)
(302 G)
(752 WP)
(2 Ib/gal or
23.8-242 EC
20-40 Ib/A
[13,000 ft
or row]
(102 G)
(75% WP)
1.5-4.5
lb/100 gal
[transplant]
at 0.5-0.75
pt/plant
(75i WP)
7.5-11.25
Ib/A
[13,100 ft
of row]
(752 WP)
Soil application. Row treatment.
Apply at planting time as dry formu-
lation to planting furrow ana cover-
ing soil. Or mix with 8 to 10 gal-
lons of water per acre and apply as
a spray. In Arizona and California
apply 0.75 to 1.016 pounds per 8 to
10 gallons of water and apply in-
furrow at planting. Avoid applying
to bare seed. Use lower rates for
lighter soils.
0.1 ppm (interim)
0.1 ppm (interim)
0.1 ppm (interim)
Soil application. Row treatment.
Apply in 12 to 15 inch band and
rototill to depth of 4 to 6 inches
immediately prior to planting. Use
lower rate on light soils and
higher rates on heavy soils.
As transplant solution. Apply 0.5
to 0.75 pint per plant. Agitate to
hold powder in solution. May also
be used in transplanting water or
sprayed on soil surface and disced
in prior to planting.
Soil application. Row treatment.
Apply as a drench in 35 gallons of
water or more as above.
Issued: 10-31-85
II-056502-4
131
-------
EPA Index Co Pesticide Chemicals
/13005AA
/13006AA
/13007AA
/130U8AA
FEACPCU
Sice ana Pest
Broccoli
Brussels Sprouts
Cabbage
Cauliflower
Club root
(Plasmodiophora)
FIAGCEF
Wire seem or
Black root
(Corticium)
/13008AA
FEACPCD
Cauliflower
Club root
(Plasmodiophora)
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Fortnula'c ion (s)
0.1 ppm (interim)
0.1 ppm (interim)
0.1 ppm (interim)
0.1 ppm (interim)
30.0-bU.U
Ib/A
(broadcast)
(10% G)
(75* WP)
11.25-15.0
Ib in not
less than
50 gal/A
(drench)
(75% WP)
19.62-40.0
Ib/A
110,000 ft
of row]
(1UX G)
(75% WP)
1.4-4.5
lb/150 gal
ac 0.5-0.75
pt/plant
[transplant]
(75% WP)
Preplant soil application.
Broadcast application. Apply
produce to aoil surface prior to
transplanting. Disc or cross-disc
or rototill Co depth of 4 to 6
inches. Hix thoroughly with soil.
Use lower rate for lighter soils
and higher rate for heavier soils.
Soil application. Broadcast drench
treatment. Apply as soil drench im-
mediately after or at time of seed-
ing. Or for smaller areas use 0.75
tablespoon actual* per 1 gallon of
water as soil drench for 50 square
feet of seed bed with a watering
can.
0.1 ppm (interim)
Soil application. Row treatment.
Apply in 12 to 15 inch bano and
rototill to deptn of 4 to 6 inches
immediately prior to planting.
As transplant solution. Apply 0.5
to 0.75 pint per plant. Agitate to
hold powder in suspension.
FIAGCEF
Wire stem or
Black root
(Corticium)
5-15 Ib/A Soil application. Row treatment.
[10,900 ft Apply in 8 inch band, centered on
of row) row, immediately prior to seeding.
(102 G) Rototill to depth of 2 inches.
Issued: 10-31-85
11-056502-5
132
-------
/28005AA
FKAGRAM
FKAGPES
FKAGFAK
FKAGTAK
FLAMUAL
/28007AA
FKAAQBB
FKABQBB
FKAFQBB
FKAHRA.M
FKAGPES
FKAFFAK
FKANQBB
Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITRQBENZENE
Dosages and Tolerance, Use, Limitations
FormulaelotU s)
Cauliflower (continued)
Corn (seed)
Rhizoctonia
Pythiun
Fusariun
Thielaviopsis
Cotranon smut
(Ustilago raaydis)
Cotton (seed)
Damping off
Seed rot
Seedling rot
Rhizoctonia
Pythium
Fusarium
Seedling disease
complex
7.3-11.25
Ib/A
(1U,*00 ft
ot row]
(drench)
(752 WP)
0.025-0.046
lb/100 Ib
(202 D)
(23.2-24.7*
EC)
(1.8 Ib/gal
or 202 RTU)
23.1-23.22
RTU)
0.3-1.0 Ib/A
(102 D)
(202 D)
(1U2 G)
or
(JOi D)
or
0.2-0.3 Ib/A
(13,000 fc of
row or 40
in. row
spacing]
(202 D)
or
0.6-3.0
lb/100 Ib
(102 D)
(202 D)
(402 D)
Soil application. Row treatment.
Apply as a drencn using 35 gallons
of water per acre. Apply in an &
inch band centered on tne row, im-
mediately prior to seeding and roto-
cill to • depth of 2 inches.
N.F.
Seed treatment. Apply dust in plan-
/ter box . Liquid formulations may
be applied undiluted Co seed, or di-
lute 5 parts,-flovable liquid concen-
trate to one part water or one part
ready-to-use to 2 parts water and
apply using suitable treating equip-
ment.
May be formulated with 5-ethoxy-3-
(trichloromethyl)-l,2,4-thiadiazole.
0.1 ppm (negligible residue)
Seed application. Apply to seed at
planting time thru planter box. Mix
product with seea in planter box.
This is a supplementary treatment
which may be used in addition to
regular seed treatment. Recalibrate
planter to proper seeding rate after
adding Che suggested dosage of pro-
duce. Follow labelling recommenda-
tions.
Hay be formulated witn thirair.,
captan ana 5-ethoxy-3-(trichloro-
methyl)-l,2,4-thiadiazole.
Issued: 10-31-85
II-056502-6
133
-------
FKADQAB
FKAGRAX
FKAGPES
FKAGFAK
FKANQBB
FKAAQBB
FKAHRAM
FKANQBB
FiCAGPES
FKABQBB
FKAFQBb
xxxxxxx
Sice and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulat ionC s)
Cotton (seed) (continued)
Soilborne plant
diseases
Rhizoc coma
Pythium
Fusarium
Seedling disease
complex
0.25-O.b Ib/A Soil application. Seed application.
(5% G) For hill drop application, apply in
(lU-i G) seed furrow and cover wicn soil ac
depth of 2 inches or more at rates
shown below:
Damping off
Rnizoctonia
(soreshinj
Pythium
Seed rot
Seedling rot
Seedling disease
complex
0.3 Ib/A
(lOi GJ
Hill drop rates:
Hill
spacing
12 in.
20 in.
12 in.
20 in.
pounds/acre
52 G
0.20
0.125
10% G
0.85
0.65
ounces/1000
ft of row
none given
none given
1.05
0.7
Treatment is not intended as a sub-
stitute for regular fungicide treat-
ment. Do not drill this product if
seed is hill dropped.
May be formulated with captan,
5-ethoxy-3-(trichloromethyl)-l,2 ,4-th
iadiazole or aldicarb.
Soil application. Seed application.
For hill drop seeding rate apply to
planting furrow and covering soil.
Use planter box at rate of 0.3
pounds per acre which correspond to
the following hill drop rates.
row .spacing
Row Spacing
Ib in.
30 in.
1.5 pounds/acre
Hill Drop Rate
2.5 pounds/acre
1.5 pounds/acre
Mix in planter box or premix in
separate container and transfer to
planter box.
Formulated with captan.
Issued: 10-31-85
II-056502-7
134
-------
FKAQBB
FKAGRAM
FKAGPES
FKAGFAK
FKANQBB
FKAAQBB
FKABQBB
FKAFQBB
FKAGRAM
FKAGPES
FKAGFAK
FKANQBB
FKAGTAK
FKAAQBB
FKAGRAM
FKAGPES
FKAGTAK
FKAGFAK
FKAGPCN
Sice and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulat ion(s)
Cotton (seed) (continued)
Damping off
Rhizoctonia
Pythiuir,
Fusarium
Seedling disease
complex
Damping off
Seed rot
Seedling rot
Rhizoctonia
Pythiure
Fusarium
Seedling disease
complex
Thielaviopsis
Damping off
Rhizoctonia
Pythiun
Thielaviopsis
Fusarium
Phytophchora
0.325-0.975
Ib/A
[drill row]
(6.5% G)
0.5-5.0
(51 G)
(6.5X G)
UOX G)
Ib/A
0.188-0.263
lb/100 Ib
(75Z UP)
(23.2* RTU)
Soil application. Apply near seeds
and over covering soil in-furrow at
planting time with granular applica-
tor, based on 13,000 feet of row
with 40 inch row spacing. Use lower
dosage for hill drop application and
higher dosage for drill planting
application method. Use of systemic
insecticides can possibly result in
damage to seed germination or stunt-
ing of seedlings under adverse con-
ditions such as extremely cold or
wet or extremely dry weather. Such
damage may be more pronounced in
light, sandy soils or when used with
certain preemergence herbicides.
Hay be formulated with 0,0-diethyl
S-[2-(ethylthio)ethyl] phosphoro di-
thioate, phorate or 5-ethoxy-3-(tri-
chloromethyl)-l,2,4-thiadiazole.
Soil application. Seed application.
Apply at planting time to open fur-
row over seed and to covering soil
using appropriate equipment and
placement procedures. Product may
also be applied as a side dress in
a band, on each side of furrow, or
as seedbed treatment; or as a green-
house treatment.
May be formulated with 0,0-diethyl
S-[2-(ethylthio)ethyl] phosphorodi-
thioate, phorate, thiram, captan,
5-ethoxy-3(trichloromethyD-1,2,4-thi
adiazole or aldicarb.
Seed treatment. Apply undiluted
product to seed or dilute by adding
water. Use treating equipment.
Also product may be transferred to
a slurry tank equipped with a posi-
tive agitator. The dye phase is
contained on a micronized solid,
therefore, must be agitated prior
to use. It should be recirculated
through the pump system for at least
Issued: 10-31-85
II-056502-8
135
-------
FKAAQBB
FDABQBB
FKAFQBB
FKAHRAM
FKAGPES
FKAGFAK
/28007AA
FKABQBB
FKAGRAM
FKAAQBB
FKAGPES
FKAGFAK
FKANQBB
FKAAQBB
FKAGRAM
FKABQBB
FKAFQBB
Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZE.NE
Dosages and Tolerance, Use. Limitations
Formulation(s)
Cotton (seed) (continued)
Damping off
Seed rot
Seedling rot
Rhizoctonia
(soreshin)
Pythium
Fusarium
1.0-2.06 Ib/A
[mixed with
5-50 gal]
[13,000 ft of
row on 40
in. row
spacing]
(30% WP)
(75% WP)
(23.2-26.49%
EC)
Cotton (acid delinted seed)
Seed rot
Rhizoctonia
Damping off
Pythium
Fusarium
Soilborne seedling
diseases
Damping off
Rhizoctonia
Seed rot
Seedling rot
0.125-0.26
lb/100 Ib
(20% WP)
(1.72-1.89
Ib/gal or
20% RTU)
23.2-24.7i)
EC)
(2 Ib/gal or
22.6-25%)
RTU)
5 minutes before filling treater
reservoir.
May be formulated with 5-
ethoxy-3-(trichloromethy 1)-1,2,4-
thiadiazole.
Soil application. Seed application.
Apply in-furrow at planting time as
spray upon the seed and surrounding
soil. May be applied by using two
nozzles per furrow. The front noz-
zle is centered over the furrow to
spray the soil around the seed and
the rear nozzle to spray the cover-
ing soil as it fills the furrow.
May be formulated with captan or
5-ethoxy-3-(trichloromethyl)-l,2,4-
thiadiazole.
0.1 ppm (negligible residue)
Seed treatment. Apply by adding 5
parts product to 1 part water or add
equal parts of water to cover the
seed.
A subsequent soil application may
be necessary where Pythium is a
problem.
May be formulated with 5-ethox>—3-
(trichloromethyl)1,2,4-thiadiazole,
or xylene.
0.25-0.3 Ib/A Soil application. Seed application.
(10-30% D) Apply dust to seed through planter
box at planting.
May be used as a supplement to
regular seed treatment.
Formulated with captan.
Issued: 10-31-85
II-056502-9
136
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EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
/28007AA
FKAGRAM
FKAGPES
FKAGFAK
FKAGTAX
FKANQBB
FKABQBB
FKAFQBB
FKAGRAM
FKAGPES
FKAGFAK
FKAGTAX
/28007AA
Site and Pest
Cotton (fuzzy seed)
Rhizoctonia
Pythium
Fusarium
Thielaviopsis
Seedling disease
complex
Seed rot
Seedling rot
Rhizoctonia
Pythium
Fusarium
Thielaviopsis
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.25-0.45
Ib/A
(10* D)
(30% D)
or
0.037 lb/100
Ib
(2 Ib/gal or
23.22 EC)
0.25-0.45
Ib/A
(102 D)
(302 D)
Cotton (reginned or mechanically
delinted seed)
0.1 ppm (negligible residue)
Seed treatment. Apply as a dust as
undiluted ready-to-use formulation
and mix with the seed using suitable
treatment equipment.
Formulated with 5-ethoxy-3-(tri-
chloromethyl)-l,2,4-thiadiazole.
Soil application. Seed application.
Apply to seed at planting through a
drill or planter box. Mix dust
thoroughly with'seed.
Before seeding, calibrate planter.
May be formulated with captan.
0.1 ppm (negligible residue)
FKABQBB
FKAGRAM
FKAAQBB
FKAGPES
FKAGFAK
FKAFQBB
FKADQAB
Seea rot
Rhizoctonia
Damping "f€
(preemergence)
Pythium
Fusarium
Seedling diseases
Soilborne plant
diseases
0.1-0.25
lb/100 Ib
(102 D)
(202 WP)
(1.72-1.89
Ib/gal or
202 F1C)
(2-2.23
Ib/gal or
242 EC)
(2 Ib/gal or
22.6-242 RTU
Seed treatment.
May be applied in dry form through
planter box at planting. Thoroughly
mix product with seed prior to fill-
ing planter box. Apply to seed
either undiluted from drum or dilut-
ee in various ways such as, 1 part
water to 5 parts product or equal
parts of water to cover seed. Use
suitable liquid or slurry equipment.
A subsequent toil application may
be necessary where Pythium is a
problem.
May be formulated with p-(dimethy-
lamino)benzenediazo sodium
sulfonate, 5-ethoxy-3-(trichloro-
metnyl)-l,2,4-thiadizole; or xylene.
Issued: 10-31-85
11-056502-10
137
-------
/14007AA
•FICRSAS
Site and Pest
Garlic (cloves)
White rot
CSc lerot iuir.)
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formu lat ion( s)
20.63 lb/100
gal solution
Ulb ft of
row based on
24 in. row
spacing]
(75% WP)
or
20.0 lb/100
gal/A
121,800 ft of
row]
(23.8-26.49%
EC)
0.1 ppm (interim)
Soil application. Row treatment.
Apply in-furrow at planting. Mix
emuisifiable concentrate or wettaole
powder formulation with water and
apply as a spray at planting time.
Attach suitable spray rig to machine
planter. Use 2 nozzles per plant-
ing furrow and direct front nozzle
to spraybottom of open furrow and
"seed" as dropped. Direct rear noz-
zle to spray covering soil.
/14007EA
FICRSAS
Garlic ("seed" cloves)
White rot
(Sclerotium)
/24003AA
FLAAL'AL
Oats (seed)
Oat smut
(Ustilago)
10.125
lb/1,000 Ib
"seed"
cloves
(75% WP)
0.03-0.064
Ib/bu
(2 lo/gal
or
25'* D)
24-25X EC)
or
0.1-0.2
lb/100 Ib
(24-24.75,
EC)
(17% FLO
(20-23.7%
RTU)
N.F.
Seed (clove) treatment. Dust cloves
thoroughly and then mist-spray with
water containing a commercial stick-
er to moisten dusted cloves.
N.F.
Seed treatment. May be applied to
seed undiluted or dilute one part
emulsifiable concentrate to 1 par:
water or 5 parts emulsifiable or
ready to use to 1 part water, use
suitable liquid or slurry seed
treating equipment. Recalibrate
equipment prior to use. Agitate
slightly to mix material.
May be formulated with xylene, or
carooxin.
Issued: 10-31-85
11-056502-11
138
-------
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
/28015AA
FKAGRAM
FKACPES
FK.AGFAK
FKAGTAK
Site and Pest
Peanuts (seed)
Rhizoctonia
Pythium
Fusarium
Thielaviopsis
Dosages and Tolerance, Use, Limitations
Forraulation(s)
FBBCSAS
Southern blight
(Sclerotiuro)
0.025-0.075
lb/100 Ib
(10-20* D)
(1.8 Ib/gal
or 202 RTU)
or
0.03-0.06
Ib/bu
(23.1-23.2%
RTU)
9.75-10.2
Ib/A
[witn 38-42
in. row
spacing or
12,500-
14,000 ft of
row]
(102 G)
(30% G)
(75X WP)
1.0 ppm (interim)
Seed treatment. Preir.ix the wetta-
ble powder formulation with the
seed directly in planter box or mix
with sufficient water and apply us-
ing suitable
treating equipment. Liquid formula-
tions may be applied uniluted direc-
tly to the seed using suitable
liquid or slurry treating equipment.
Recalibrate equipmentprior to use.
Product may contain non-oil lubri-
cant.
May be Formulated with 5-ethoxy-3-
(tri-chloromethyl)-l,2,4-thiadiazole;
maneb, and captan
Soil application. Apply at planting
in a 12 to 14 inch band centered on
the row and mix to a depth of 1.5
to 2 inches or apply in an b to 12
inch band and mix to a deptn of 2
to 4 inches. Use suitable equipment
for in-furrow application. Avoid
techniques of application which will
allow direct contact of the granules
with the seed.
May be formulated with p-(dimethyl-
amino)-benzenediazo sodium
sulfonate.
FBBCSAS
Southern stem and
root rot
(Sclerotium)
3.0-3.4 Ib/A Soil application. Apply dry formu-
[12,500 ft of lations as soil mix during each of
row)
(10% G)
or
3.0 lb/8-10
gal/A
(75% WP)
3 cultivations. Attach 2 delivery
tubes per row ahead of inside culti-
vator sweeps (one on each side) and
adjust to treat a total band 12
inches wide, centered on row. Or,
mix wettable powder formulation in
8 to 10 gallons water and apply at
the per acre rate.
Issued: 10-31-85
11-056502-12
139
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Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
FormulationC s)
Peanuts (seed) (continued)
FBBCSAS
Southern stem and
root rot
(Sclerot iuir,
rolfsii)
/28016AA
/28023AA
FICBABI
FKAGRAM
FKAGFAK
FKAGPES
FKAGTAK
Peas (seed)
Soybeans (seed)
Aphanomyces
Rhizoctonia
Fusariuir.
Pythium
Thielaviopsis
9.75-10.2
Ib/A
112,500 ft of
row]
(10% G)
(30% G)
or,1
9.75
lb/12,400
ft row
or
9.7 lb/8-10
gal
(75% WP)
Soil application. Row treatment.
Surface band application. Apply at
pegging time in b to 12 inch band
centered on row or directed at plant
crown and soil pegging zone or, if
cultural practices permit may be
applied with land plaster. Or, may
be applied as side-dressing (at per
acre rate of 0.1 pounds per 124 feet
of row). Add to 10 gallons of water
per acre to the wettable powder and
direct the spray to center of row
in 12 inch band to cover crown of
plant and pegging zone. If middles
are cultivated at same time, attach
2 delivery tubes or nozzels, one to
eachside and ahead of cultivator
sweeps.Do not use more than one ap-
plication method during same plant-
ing season.
May be formulated with 0,0-diethyl
S-(2-(ethylthio)ethyl)
phosphorodithioate.
N.F.
N.F.
0.025-0.051
Ib/A
(lOi D)
(20% D)
or
0.03-0.06
Ib/bu/A
(23.2% EC)
(2 Ib/gal or
Seed treatment. Preraix dry formula-
tions with seed and apply at plant-
ing time through planter box at rate
of approximately 1 bushel per acre,
or mix 0.8 to 1.6 pounds with 1 gal-
lon of water and apply with slurry
treater. Product may contain a non-
oil lubricant. Premix undiluted
liquid formulations (RTU) with seed
10-23.2% RTU) just prior to planting. Ready-to-
use may be applied as a planter box
application but should be flushed
with water at end of each day's op-
eration and thoroughly cleaned at
end of planting season, (where
^molybdenum is required, the 4.5
ounce formulated rate is equivalent
to 0.25 ounce molybdenum as metal-
lic, per acre). The ready to use
formulation may be diluted by adding
Issued: 10-31-85
11-056502-13
140
-------
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Site and Pest
FKAGFAK
FKAGPES
FKAGRAM
FKAGTAK
Dosages and Tolerance, Use, Limitations
Formulation( s)
Peas (seed) (continued)
Fusarium
Pythium
Rhizoctonia
Thielaviopsis
0.026-0.75
Ib/bu
or
0.0525 lb/
100 lb
(30% D)
(24.7% EC)
17% FLC
1 part prpduct to 2 parts water and
applied using suitable treating
equipment.
Formulated with 5-ethoxy-3-(tri-
chloromethyl)-l,2,4-thiadiazole.
Seed treatment.
May be formulated captan; or
carboxin.
/28016AA Peas (seed)
/28023AA Soybeans (seed)
FKAGFAK Fusarium
FKAGPES Pythiura
FKAGRAM Rhizoctonia
FKAGTAK Thielaviopsis
/11003AA Peppers
/11005AA Tomatoes (bed grown)
FBBCSAS Southern blight
Issued: 10-31-85
N.F.
N.F.
0.053-0.105 Seed treatment. Apply undiluted to
Ib/lUO lb seed or dilute 1 part water to 5
(1.8 Ib/gal orparts formulation. Use suitable
20% RTU) liquid or slurry creating equipment.
Formulated with 5-ethoxy-3-(tri-
chloromethyD-1,2 ,4-thiadiazole.
0.1 ppm (interim)
0.1 ppm (interim)
7.5 Ib/A Soil application. Row treatment.
(75X WP) Apply as dust or spray (use 100 gal-
lon per acre for'wettable powder)
over open "V" trench prior to set-
ting transplants. Set plants in
bottom of trench then press walls
of trench against stems of young
transplants. Linear row feet per
acre for the various systems is
given as follows: 7,300 feet for
non-staked tomatoes, 10,900 feet
for staked tomatoes, 14,500 feet
for peppers.
2.25-3.75 For transplant solution mix 2.25-
lb/100 gal 3.75 pounds vettable powder in 100
[transplants] gallons of water and apply 1/2 pint
(752 WP) of mixture per plant at transplant-
ing time to cover soil at base of
plant.
11-056502-14
141
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EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Site and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
/14013AA
FKAGRAM
Potatoes (seed piece)
Rhizoctonia solani
/24006AA
FKAGRA.M
FKAGPES
FKAGFAK
FKAGTAK
FKADQAB
FKACQBB
FKAFQBB
Rice (seed)
Rhizoctonia
Pythiura
Fusarium
Thielaviopsis
Soilborne plant
diseases
Seedborne diseases
Seedling diseases
0.1 ppm (interim)
10*0 Ib/A soil application. Row treatment.
(30/4 G) Apply dry in-furrow in a 12 to 15
(75/. WPJ inch band -centered on row, and work
(2 Ib/gal. or product thoroughly into top 4 to 6
23.8-24% EC) inches of soil (tuber-forming zone
and soil that surrounds and covers
seed piece). Apply liquid formula-
tion at planting to tuber-forming
zone. Use in sufficient water to
total 20 gallons. Use 2 or 3 noz-
zles per row. It is desirable to
treat when soil is slightly moist.
18.0-25.0
Ib/A
(30% G)
(75% WP)
(2 Ib/gal or
Soil application. Broadcast appli-
cation. Apply dry or liquid formu-
lation mixed with water to the soil
surface prior to planting. Use 25
to 150 gallons per acre for wettable
23.8-24% EC) powder or eraulsifiable concentrate
formulations. Thoroughly mix (disc
and cross-disc) in soil to a depth
of 4 to 6 inches.
0.07-0.14
lb/100" Ib
(1.8 lt>/gal
or 20% RTU)
or
0.03-0.06
Ib/bu
(23.2% EC
23.1-23.2%
RTU)
N.F.
Seed treatment. Apply undiluted to
seed or mix either 5 parts ready-to-
use with 1 part water or one part
flowable to 2 parts water and apply
using suitable liquid or slurry
treating equipment.
Formulated with 5-ethoxy-3-tri-
chloromethyl)-l/2,4-thiadiazole.
Issued: 10-31-85
11-056502-15
142
-------
/27008AA
FKANQBB
FKACQ5B
FKAFQBB
FKADQAB
FKAGFAK
FKAGPES
FKAGRAM
FKAGTAK
/28019AA
FICBABI
FLAEUAL
FKAGRAM
FKAGPES
FKAGFAK
FKAGTAK
FKANQBB
/28020AA
FKAGABI
FKAGFAF
FKAGPES
FKAGRAM
Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENt
Dosages and Tolerance, Use, Limitations
Formulat ion(s)
Safflower (seed)
Seedling disease
complex
Seedborne disease
Seedling diseases
Soilborne diseases
Fusarium
Pythium
Rhizoctonia
Thielaviopsis
Sorghum (seed)
Aphanomyces
Coverea kernel smut
(Ustilago)
Rhizoctonia
Pythium
Fusarium
Thielaviopsis
Seedling disease
complex
N.F.
0.025-0.075
lb/100 lb
(20« D)
(23.2% EC)
20-23.2%
RTU)
or
0.032-0.064
Ib/bu
(24.72 EC)
0.025-0.041
lb/100 lb
(2U%,D)
(23.2i EC)
(20-23.22
RTU)
or
0.05(5 Ib/bu
(30* D)
Sugar Beets (sees) N.F.
Aphanooyas
Fusarium
Pythium
Rhizoctonia
0.075-0.19
lb/100 lb
(202 0)
(23.22 EC)
23.12 RTU)
Seed treatment. Dry formulations
may be applied after premixing (W?)
witn seed in planter box or mixing
(WP) with sufficient water or mix
0.8 to 1.6 pounds in 1 gallon of
water and apply through slurry
treater calibrated to deliver recom-
mended dosage. Liquid formulations
may be applied undiluted to seed or
add 1 part product to 2 parts water
or add 5 parts product to 1 part
water. Use suitable liquid or slur-
ry treating equipment.
May be formulated with 5-ethoxy-3-
trichloromethyl)-l,2,4-thiadiazole.
N.F.
Seed treatment. Apply liquid formu-
lations undiluted to seed,or mix
with sufficient water or mix O.b to
1.6 pounds per 1 gallon of water or
mix 1 part ready-to use with 2 parts
water or 5 parts (F1C) with 1 part
water. Use suitable treating equip-
ment such as liquid or'slurry
treater which has been calibrated
to deliver recommended rates.
Slight agitation may be required to
mix the materials.
May be formulated with p-(dimethy1-
amino)benzenediazo sodium sulfonate
and 5-ethoxy-3-trichloromethyl)-
1,2,4-thiadiazole.
Seed treatment. Apply in planter
box..
Formulated with 5-ethoxy-3-trichlo-
romethyl)-!,2,4-thiadiazole.
Issued: 10-31-85
11-056502-16
143
-------
/24007AA
FICBAB1
FKANQBB
FLATTAQ
Site and Pest
Wheat (seed)
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Fortnulat ion( s)
Aphanomyces
Seedling disease
complex
Common smut (bunt)
0.025-0.047
Ib/bu
(20-3CK 0)
(75* WP)
23.2- 242
EC)
23.1-252 RTU
or
0.05- lb/100
Ib
(2.23 Ib/gal
or 24% EC)
(172 F1C)
(17.68-202
RTU)
N.F.
Seed treatment. Apply dry product
by premixing with 1 bushel seed
directly in planter box or mix 0.8
to 1.6 pounds product per gallon
water and apply through slurry
treater or apply to seed after mix-
ing product with sufficient water.
Liquid formulations may be applied
undiluted to seed or diluted by ad-
ding 1 part water to 1 to 2 parts
product. Use suitable treating
equipment such as slurry or mist
seed treater. Or, liquid formula-
tions may be applied undiluted to
100 pounds seed after mixing 5 parts
product to 1 part water. Use suita-
ble liquid or slurry treating equip-
ment.
May be formulated with lindane; cap-
tan; 5-ethoxy-3-trichloromethyl)-
1,2,4-thiadiazole; xylene; or
carboxin.
Issued: 10-31-85
11-056502-17
144
-------
/31012AA
/31003AA
/31034AA
/31057AA
/31065AA
/31159AA
/31184AA
FICBQBB
FKAGRAM
FKAAQBB
Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulation(s)
TERRESTRIAL NON-FOOD CROP
Ornamentals Plants and Forest Trees
African Violet
Bedding Plants
Begonia
Carnation
Chrysanthemum
Poinsettia
Snapdragon
Stem rot
Rhizoctonia
Damping off
0.8-1.5
lb/1000
sq.ft
(10% G)
(75% WP)
or
1.875 lb/300
gal/1000
sq.ft of
bench or bed
(75% WP)
or
0.092 Ib/gal
in 30 gal/50
sq.ft
(2.05 Ib/gal
or 24% EC)
Soil application. .May be applied
in dry fora to soil surface and
mixed thoroughly into top 2 inches
of soil, or mixed with water and
apply to well prepared seedbed.
Also may be applied as soil drench
after mixing with water. May be
applied before planting to seed-
bed.
May be formulated with captan.
/34022AA
FBADOAV
Azalea
Ovulinia petal
blight
0.75 lb/150
sq.ft
(75X WP)
(2 Ib/gal
or
23.8-24% EC)
0.0469
Ib/sq.yd
[of azalea
bed]
(75% WP)
Soil application. Apply as dust to
ground beneath bushes and surround-
ing area beginning prior to opening
of buds and repeat every 3 to 4
weeks through bloom period.
Apply in sufficient water.
Soil application. Begin 4 to 6
weeks before bloom and apply as a
single spray to azalea beds, or ap-
ply as a dry mixture after blending
with sand, sawdust or vermiculite.
Issued: 10-31-85
11-056502-18
145
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Site and Pest
Azalea (continued)
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulation(s)
/34036AA
FBADSAQ
Camellia
Camellia flower
blight
(Sclerotinia)
/31050AA
/31129AA
/31184AA
/31197AA
FICHSAQ
Calendula
Larkspur
Snapdragon
Sweet Peas
Stem rot
(Sclerotinia)
0.422-0.562
lo/lOO gal
(75J, WP)
Foliar and soil applications. For
blossom spray, use higher dosage and
begin as first blossoms start to
open. Use fine mist and apply
lightly and thoroughly to all buds
and open flowers, also spray ground
surface beneath bushes until moist.
Repeat at 4 Co 5 day intervals or
as new blossoms appear. Use lower
dosage when new foliage appears and
continue as in blossom spray. Avoid
spraying interplanted species.
Formulated with cycloheximide.
200.0 Ib/A Soil application. May be applied
or during early winter to soil surface
0.25-0.5 or leaf litter beneath bushes. Con-
lb/100 sq.ft tinue applying at weekly or biweekly
.intervals prior to and during flo-
wering season, especially following
rains or damp weather. Or may be
applied prior to opening of buds and
repeated every 3 to 4 weeks through
bloom period.
(75% WP)
(23.8* EC)
100.0 Ib/A
or
0.2-0.25
lb/100 sq.ft
(10* G)
(75% WP)
or
0.12 lb/25
gal/50 sq.ft
(2.05 Ib/gal
or 242 EC)
Soil application. Product was de-
veloped for this use in Charleston,
SC. May be applied as broadcast 1
week before planting. Spread dry
product on soil surface and uniform-
ly mixed in soil to depth of 4
inches (6 inches for 10 percent of
dust). The emulsifiable concentrate
formulation may be applied as a soil
drench 1 week before planting. May
be formulated with captan.
Issued: 10-31-85
11-056502-19
146
-------
/31111AA
FIBQSEA
FLAPSEA
FIAPSAQ
/31123AA
/31044AA
/31142AA
/31025AA
FIAXQBB
FIBFQBB
Site and Pest
Gladiolus
Neck rot
(Scromacinia/
Sclerocinia)
Bulb roc
(Scromacinia)
Bulb rot
(Sclerocinia)
Hyacinth
Iris (bulbous)
Narcissus
Tulips
Crown rot
Black rot
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limications
Formulaeion(s)
120.0 Ib/A
or
0.15 To/100
sq. f c
[broadcasc]
(10% G)
or •
2.75 lb/1000
sq.ft
[broadcast]
(75% WP)
or
4.125 lb/1000
sq.ft row
(75% WP)
Soil application. Broadcasc or row
creacment. Apply at planting cirae
Co soil surface and mix choroughly
in upper 4 to 6 inches of soil using
suitable cultivation equipment. For
row treatment, apply in a two inch
band. Bulbs may be planted immedi-
ately.
100.0-200.0
Ib/A
or
0.2-0.4
lb/100 sq.ft
[broadcast ]
(10X G)
or
2.44-4.6-7
lb/1000
sq.ft
[broadcast]
(75% WP)
Soil application. For broadcast,
apply dry to soil prior to planting
and mix thoroughly in upper 6 to 7
inches of soil by double discing or
rotovating. For bulbous iris (0.5
pounds per 100 square feet), spread
product on soil surface and evenly
distribute in soil to depth of 4 to
6 inches. Best results follow
treatment in fall. For tulip beds,
apply at planting time on heavily
infested soils. Use digging fork
or rototiller and work product into
soil to depth of 6 to 10 inches.
For row treatment apply to row at
time bulbs are planted, dust sides
and edges of open furrow and bulbs,
then close furrow. Use high rate
for black rot control and for heavi-
er soils. Or bulbs may be dipped
for 5 minutes in 7.5 percent concen-
Issued: 10-31-85
11-056502-20
147
-------
Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Fornulat ion(s)
Hyacinth cluster (continued)
/31093AA Lilies (Easter)
FICBRAM Rhizoctonia root
rot
or
3.37-*.5
ID, 1UUL- ft
row
(75* WP)
or
2.25 lb/4.85
gal .water
[bulb dip]
(75% WP)
100.0-200.0
Ib/A
[broadcast]
or
0.2-0. A
lb/100 sq.ft
[broadcast]
G)
tration (2.25 pounds per 4.S5 gal-
lons water) to wnich has been aace.
1 percent sticker. Maintain gooc
agitation in dip tank.
May be formulated with captan.
or
2.44-4.875
lb/1000
sq.ft
or
[broadcast]
(75* WP;
or
3.375-^.675
Ib/lUUO ft
row
(75i WP)
or
3.0-4.5
10/100 gal
[bulb dip]
(75X WP)
Soil application. As broadcast, ap-
ply to soil surface prior to plant-
ing and mix thoroughly in upper b
to 7 inches by double discing or ro-
tovating. For furrow, apply at time
bulbs are planted. Use lowerrates
for light soils and higher rates for
heavier soils. For bulb dip, sus-
pend 3.0 to 4.5 pounds in 100 gal-
lons of water and dip bulbs for 5
to 15 minutes. A sticker may be ad-
dea to dip. Maintain good agita-
tion in dip tank.
Issued: 10-31-85
11-056502-21
148
-------
/31382AA
FIAPSAS
FIAASAS
/31003CA
/31003AA
34004AA
/34004CA
FICBPES
FICHPCN
FICHRAM
FICHPCN
FICHPES
FICHRAM
Site and Pest
Iris (Dutch)
Bulb rot
(Sclerotium
rolfsii)
Stem rot
(Sclerotium
rolfsii)
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulat ion(s)
100.0-150.0
Ib/A
or '
0.2-U.4
lb/100 sq.ff
[broadcast]
(102 G)
or
2.4-3.375
lb/1000
sq.ft
[broadcast]
(752 WP)
or
6.0 lb/14,500
ft row
[band]
(10% G)
0.375 16/1000
ft row
(75* WP)
Soil application. As broadcast, ap-
ply granules or spray prior to plan-
ting. Mix witn 2 to 3 inches
of soil by discing and rototilling.
May also be applied at planting time
•• a spray in 12 inch band centered
on row. Repeat 3 times at 15 day
interval.
Ornamental Flowering Plants
Ornamental Woody Shrubs
Root rot
(Pythiutn)
Root rot
(Phytophthora)
Root rot
(Rhizoctonia)
Stem rot
(Phytophthora)
Stem rot
(Pythium)
Stem rot
(Rhizoctonia}
0.05-0.075 Soil application. Broadcast over
oz/sq.ft of bench or bed area and thoroughly
bench or bed work product into top 6 inches of
area soil. Or thoroughly mix soil and
(52 G) product in container.
Formulated with p-(dimethy1amino)-
benzenediazo sodium sulfonate.
Issued: 10-31-85
11-056502-22
149
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Sice and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulation(s)
/35217AA
FDAFRAM
Pine (Southern) (seedlings)
Rhizoc tonia
blight
needle
37.5 Ib/A Soil application (in nursery beds).
(75?. WP) Apply in 100 gallons of water and
use an additional 1/2 inch of water
applied by irrigation. Seed may be
planted immediately after irrigation
or up to 1 week later.
/34120EA
FICJBAW
Roses
Botrytis storage
rot
/3S216AA
FMBCPCE
Southern Magnolia
Leaf spot
(Phyllosticta)
(10% D)
(20% D)
or
0.75-1.5
lb/100 gal
[dip/spray]
(752 WP)
Storage treatment. May be applied
by dusting bushes liberally immedi-
ately after stacking them root-to-
root. As dip, nix 0.75 to 1.5
pounds per 100 gallons of water and
dip dormant roses prior to storage.
Maintain good agitation in dip tank.
As spray, mix 1.5 pounds per 100
gallons of water and thoroughly
spray dormant roses prior to stor-
age.
1.5 lb/100 Foliar application. Add a spreader-
gal sticker at rate of 1 pint per 100
(75% WP) gallons of water. Apply at least 4
sprays at 2-week intervals to foli-
age beginning approximately 1 week
prior to time disease is likely to
occur. Do not use on Magnolia fus-
cata as injury may result.
Issued: 10-31-85
H-056502-23
150
-------
/33006AA
/ 3 3015AA
/33019AA
/33023AA
/33031AA
/33034AA
/33043AA
/33050AA
/33051AA
FBAHRAM
FMAQSAQ
FMBCQAB
FJAAQBB
FHAJTCB
FHAJFAK
Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulation(s)
(Ornamental lawns and turf (including ground covers))
Ornamental Lawns (warm season)
Bahiagrass
Bluegrass*
Centipedegrass
Fescue
Kentucky Bluegrass
Ryegrass (perennial)*
St. Augustinegrass
Tall fescue*
Brown patch
(Rhizoctonia)
Dollar spot
Leaf spot
Rust
Gray snowmold
(Typhula)
Pink snowmold
(Fusarium)
0.496-0.916
lb/1,000
sq.ft
(9.95-16.9%
G)
Foliar application. Apply when
foliage is dry. If temperature is
80 F or above, sprinkle to rinse
granular off grass blades. To pre-
vent dollar spot, leaf spot, rust
and stripe smut on Kentucky blue-
grass apply in fall and spring. To
prevent snowmold apply prior to
first snowfall. If dollar spot or
rust become active during summer,
apply at first indication of dis-
ease. As control for active dis-
ease, make a second application one
month later. In South Florida apply
in November and February as preven-
tive for brown patch on bahiagrass,
centipedegrass and St. Augustine-
grass. A winter application may be
needed if weather is favorable to
disease development.
Do not use product on;
1) bentgrass or zoysiagrass, or
2) mixed lawns of bluegrass and fine
fescue where fescue is the de-
sired variety, or
3) turf in California on other than
bluegrass and then only from late
fall through early spring.
Also, do not use any other control
product (such as weed control) for
one week after applying.
*Disease control for additional grasses claimed by certain formulations.
Issued: 10-31-85
11-056502-24
151
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Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulation(s)
/33006AA
/33015AA
/33017AA
/J3023AA
/33051AA
/3305UAA
FBAHRAM
FMAQSAQ
FMBCQAB
FJAAQBB
Ornamental Lawns (warm season)
Bahiagrass
Bermudagrass
Centipeoegrass
Tall fescue-
St. Augustinegrass
Brown patch
(Rhizoctonia)
Dollar spot
(Sclerotinia)
Leaf spot
Rust
(Puccinia)
0.49-0.994
lb/1,000
sq.ft
(13.57% G)
(15.4% G)
Foliar application. Apply when
foliage is dry. If temperature is
80 F or above, water lightly. Use
drop spreader (preferred). Rotary
spreader application should be made
with extreme caution. As a preven-
tive for brown patch control on ba-
hiagrass, centipedegrass, and St..
Augustinegrass apply higher rate in
early fall (September and October);
repeat in late winter or early
spring; or, for control of active
disease apply when symptoms are
first noticed. Repeat in one month
of disease persists. As a disease
preventive on bermudagrass, apply
lower rate to dry foliage in fall
and early spring for leaf spot; also
for dollar spot, apply in late
spring/summer when disease is usual-
ly expected. Also as control for
dollar spot, leaf spot and rust on
bermudagrass, apply lower rate at
first sign of disease. Repeat in 1
month if disease persists. For ber-
mudagrass and tall fescue, as pre-
ventive or control for brown patch,
apply lower rate during times of
disease activity and when disease
is expected. Repeat monthly as
needed.
Restrictions - do not use product
on;
1) dichondra or stands of predom-
inantly fine fescue, or
2) tall fescue during warm summer
months in Southern United States,
or
3) bermudagrass in Florida, Southern
Alabama, Southern Mississippi,
Louisiana, Southern Texas and
California, or
Issued: 10-31-85
11-056502-25
152
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Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulation(s)
/33016AA
/33017AA
/33050AA
FBAHRAM
FMAQSAQ
FBATCFH
FMAXPCR
FMAYPES
FMBCHAM
FBATHAM
FBAHRAM
FBATCFH
FMAXPCR
Ornamental Lawns (warm season) cluster (continued)
4) Poa annua where turf is desired
in Southern United States, or
5) winter overseeded bermudagrass
putting greens.
To prevent seedling damage do not
allow excessive growth to occur in
spring before first mowing. Product
contains a fertilizer.
Bentgrass
Bermudagrass
St. Augustinegrass
Brown patch
(Rhizoctonia)
Dollar spot
Fading out
(Curvularia)
Gray leaf spot
(Piricularia)
Grease spot (turf)
(Pythium)
Leaf spot
(Helrainthosporium)
Melting out
(Heltninthosporium)
0.056-0.075
lb/25-35
gal/1000
sq.ft
(75?. WP)
Brown patch
(Rhizoctonia)
Fading out
(Curvularia)
Gray leaf spot
(Piricularia)
0.035 lb/10
gal/1000
aq.ft
(14% UP)
Foliar application. For turf, add
product to water, agitate suspension
and apply as spray with band or
power sprayer or hose-on proportion-
er. Use spray mixture the same day
as it is prepared. Allow spray to
dry on grass. Do not "water in"
afterwards. Avoid mowing for 12
hours after applying. Avoid spray-
ing during periods of high tempera-
tures. For bentgrass, bermudagrass,
and St. Augustinegrass, as a preven-
tive apply lower rate in the spring
before disease symptoms appear, tnen
at 7 to 14 day intervals throughout
the season when conditions favor
disease development. As a curative
apply higher dose when disease is
already present or develops despite
preventive spray. Repeat at 3 to 5
day interval until disease is con-
trolled, then follow preventive
schedule.
Formulated with cycloheximide.
Foliar application. Special formu-
lation for Florida turf. Apply as
•pray every 3 to 7 days as preven-
tive when disease product ing condi-
tions are present.
Formulated with thiram and captan.
Issued: 10-31-85
11-056502-26
153
-------
/33005AA
/33019AA
/33043AA
/33005AA
/33007AA
/33007AA
/33007AA
/33019AA
/33113AA
/33049AA
/33025AA
FHAJQBB
Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
FortiiUlat ioru s)
Ornamental Lawns (cool season)
Bluegrass
Ryegr-ass (perennial)
Stripe smut
(Ustilago)
lb/1,000
sq.ft
(13.57% G)
(15.40% G)
Ornamental Lawns (cool season)
Ornamental Turf (golf fairways)
Ornamental Turf (putting greens)
Ornamental Turf (golf tees) -
Bluegrass
Fescue (fine)
Ryegrass (perennial)
Bentgrass
Snow mold
0.49-0.994
lb/1,000
sq.ft
(13.57% G)
(15.40% G)
Foliar application. Apply xn fall
and spring as preventive. For con-
trol apply when symptoms are first
noticed. Repeat in 1 month for se-
vere infections. In California, ap-
ply only on bluegrass turf in fall
through early spring. Product con-
tains a fertilizer.
Foliar application. Apply lower
rate as preventive for snow mold
prior to first heavy snowfall. Ap-
ply higher rate in areas where snow
cover is present the entire winter.
For putting greens and tees with
bentgrass apply in mid-fall through
early winter period. Product con-
tains a fertilizer.
/33019AA Bluegrass
/33113AA Fescue (fine leaf)
/33043AA Ryegrass (perennial)
FMBCQBB Leaf spot
FMAQSAQ Dollar spot
FJAAPEJ Rust (Puccinia)
0.49-0.499 Foliar application. Apply lower
lb/1,000 rate for control when disease symp-
sq.ft toms are first noticed. Repeat in
(13.57% G) 1 month if disease persists. Apply
(15.40% G) in fall and early spring to prevent
leaf spot. Use appropriate spreader
settings. For dollar spot apply
when disease is usually expected.
Apply higher rate for control at
first sign of rust. Repeat in 1
month for severe infections. In
California apply on bluegrass turf
only. Product contains a fertiliz-
er.
Issued: 10-31-85
11-056502-27
154
-------
/33005AA
/33034AA
FMBCHAM
FLAUUAL
FHAJTCB
/33050AA
FBAHRAM
/33005AA
/33034AA
FHAJFAK
FLAUUAL
FMBCRAD
FJAAQBB
FMAQSAQ
Sice and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
FormulationCs)
Ornamental Lawns (cool season)
(bluegrass)
Kentucky bluegrass (Merion and
Windsor varieties)
Leaf spot 0.935
((telminthosporium) lb/1,000
Stripe smut sq.ft
(Ustilago) (15.4.0% G)
Snow mold
(Typhula)
St. Augustinegrass
Brown patch
(Rhizoctonia)
Foliar application. Apply twice a
year. In spring apply in March,
April or May but at least before
temperatures are consistently in
80's. In fall apply in September
or October but at least before first
heavy snow. If temperatures are 80
F or above, apply when grass blades
are dry and water immediately to
wash granules off grass blades.
Product contains a fertilizer.
0.98 lb/1,000 Foliar application. Apply in late
sq.ft winter or early spring and again in
(15.40% G) early fall (September-October), or
if extreme weather makes it neces-
sary, treat after 1 month. Product
contains a fertilizer.
Ornamental Lawns (cool season)
Kentucky Bluegrass
Snow mold
(Fusarium)
Stripe smut
Leaf spot
Rust
Dollar spot
0.98 lb/1,000 Foliar application. Apply prior to
sq.ft first expected snow. Use appropri-
(15.40* G) ate spreader equipment. Product
contains a fertilizer.
0.98-0.96 Foliar application. Apply lower
lb/1,000 rate for control of all pests shown
sq.ft when symptoms are first noticed.
(15.40% G) Or, apply higher rate for control
of heavily infested areas, or repeac
lower rate in 1 month. Or, apply
lower rate for control of stripe
smut and leaf spot in spring and
fall each year. Use appropriate
spreader equipment. Product con-
tains a fertilizer.
Issued: 10-31-85
11-056502-28
155
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EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Site and Pest
Dosages and Tolerance, Use, Limitations
Forrnulat ion(. s)
/33019AA Bluegrass
/33031AA Fescue
/330«43AA Ryegrass
FJAA^BB Rust
FFACQBB Powdery mildew
FBATCFH Fading out
(Curvularia)
FBATHAM Melting out
(Helminthosporium)
FMBCHAM Leaf spot
(Helminthosporium)
FMAYPES Grease spot
(Pythium)
/33008AA Ornamental Turf
/33010AA Ornamental Lawns
FHAJTCB Snow mold
(Typhula)
FHAJFAK Snow mold
iFusarium)
0.02 j Ib/in
2.5-5
gal/1000
sq. ft
(75X1 WP)
Foliar application. As preventive,
apply in spring before disease symp-
toms appear then apply 7 to 14 day
intervals throughout season. As
eradicative, apply when disease is
already present or develops despite
preventive program. Repeat at 3 to
5 day intervals until disease is
controlled then follow preventive
schedule.
Formulated with cycloheximide.
0.5-0.75 Foliar application. Apply prior to
lD/1,000 first snowfall using a granular lawn
sq.ft spreader or comparable equipment.
(10-12.5i G)
or
0.375 lb/
1,000 sq.ft
WP)
/33010AA
FMBCHAM
/33017AA
/FBBLLAS
Ornamental Lawns
Helminthosporium
leaf spot
Bermudagrass
Spring dead spot
(Leptosphaeria)
0.5-0.75 Foliar application. As a preven-
lb/1,000 tive, apply in spring or fall of
sq.ft each year. For control of existing
(10-12/5%'G) infections, apply higher rate when
symptoms are noted and lightly water
treated area afterwards. Repeat 3
to 4 weeks later if treated area is
subjected to unusually heavy rain-
fall, or flooded or if disease is
severe or reappears.
1.0 lb/1,000 ., Foliar application. For suppression
sq.f c
(10% G)
of existing infection, apply in the
spring or fall of each year. Water
lightly following treatment.
Formulated with 5-ethoxy-3-(trichlo-
romethyl)-l,2,4-thiadiazole.
Issued: 10-31-85
11-056502-29
156
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EPA Index to Pesticide Chemicals
PENTACHLORON1TROBENZENE
Sice and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
/33010AA Ornamental Lawns
/33008AA Ornamental Turf
/FKAVQBB Damping-off
(including seed-
ling diseases
/FKAVFAK Fusarium
/FKAVHAM Helminthosporium
/FKAVPED Pythium
/FKAVRAM Rhizoctonia
1.0 ID/1,000
sq. ft
(10* G)
Foliar application. Apply to grow-
ing turf in the fall or spring at
the first indication of infection.
Water lightly. For areas to be
seeded, apply prior to seeding. Mix
in the Cop 1 or 2 inches of soil.
If any Created area is subject ot
unusually heavy rainfall, or flood-
ed, or if Che disease is several or
reappears, repeat treatment 3 to a
weeks later.
Formulated with 5-ethoxy-3-(trichlo-
rotnethy i)-l. 2.4-thiadiazole.
/33010AA Ornamental Lawns
/33050AA St. Augustinegrass
FBAHRAM Brown patch
(Rhizoctonia)
0.985 Foliar application. As preventive,
lb/1,000 apply 2 times per year (once in late
sq.ft winter or early spring and again in
(15.40% G) early fall, from September to Octo-
ber). Apply Co dry foliage using
appropriate spreader and settings.
May be used on established lawns or
at planting of new lawns. Sprinkle
created areas if temperature is 80
F or more.
/33005AA
/33010AA
/33019AA
/33031AA
/33040AA
/33016AA
FBAHRAM
Ornamental. Lawns (cool season)
Ornamental Turt (lawns)
Bluegrass
Fescue (fine)
Ryegrass
Bentgrass
Brown patch
(Rhizoctonia)
0.19-0.37 Foliar application. Apply before
lb/1,000 disease is expected Co appear and
sq.fc at first sign of disease ana water
(4.67% G) treated area afterwards. Repeat
(10-12.51 G) every 7 co 10 days during hot, damp
Issued: 10-31-85
11-056502-30
157
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Site and Pest
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages ana Tolerance, Use, Limitations
For-jlat ionts )
Ornamental Lawns (cool season) (continued)
or
U. li-0.Itil
ID j-t>
gai,10UU
sq.ft
(75% WP)
(2.05 Ib/gal
or 24% EC)
weather or apply as a spray (prepar-
ed by adding product to water).
Or, for i.b7 percent granular torT.u-
'lation, apply at time disease nor-
mally appears using appropriate
spreader settings and equipment and
water in lightly; repeat in 6 weeks
if disease conditions aresevere or
reappear. Labeling of 4.67 percent
granular formulation also claims as
cool season grasses: bentgrass,
creeping red fescue, Kentucky blue-
grass, Merion bluegrass, redtop and
ryegrass. Product contains a fer-
tilizer.
/33010AA
/33017AA
/33050AA
FBAKRAM
Ornamental Lawns (warm season)
Bermudagrass
St. Augustinegrass
Brown patch
(Fusarium)
0.5-0.6
ID/1,000
sq.ft
(2% G)
(2.25;i G)
(10-12. 5* G),
(75% WP)
(2 Ib/gal or
23.iS-2<»% EC)
U.Olo-2.05
Ib/gal or
24% EC)
or
0.37 lb/1,000
sq.ft
(4.67% G)
Foliar application. Apply in fall
or spring at first brown patch symp-
toms and moderately water treated
area. Repeat 3 to 4 weeks later if
treated area is subjected to heavy
rainfall or is flooded.or if disease
is severe or reappears. Or, for
4.67 percent granular formulation
apply once at time disease normally
appears using appropriate settings
and equipment and water it lightly.
Repeat in 6 weeks if disease condi-
tions are se vere and reappear. La-
beling of 4.b7 percent granular for-
mulation claims as Southern grasses:
bahiagrass, centipedegrass, common
bermudagraes, Kentuctcy 31 fescue,
Maryland bentgrass, ryegrass, Texas
turf 10, Tifgreen, Tifine, Tifway
and Snyder bermudagrass, Seaside
bentgrass, St.Augustinegrass and
zoysiagrass. Addeither 10 to 15
gallons or 15 to 20 gallons of water
to emulsifiable concentrate formula-
tion and apply. Product may contain
a fertilizer.
May be formulated with carbaryl.
Issued: 10-31-85
11-056502-31
158
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Site and Pest
/33028AA Dichondra
FBAHRAX Brown patch
(Rhizoctonia)
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Dosages and Tolerance, Use, Limitations
Formulat lonl. s)
0.75 lb/1,000 Foliar application. Apply in fall
sq. ft
U.'.37-12. 3'".
G;
or
0.75-0.768
lb/40
gal/1000
sq.fc
(75% WP)
(2 Ib/gal or
23.9-24% EC)
(2.05 Ib/gal
or 24% EC)
or
0.75 lb/10-15
gal/1000
sq.ft
(2 Ib/gal or
24% EC)
or spring (as in warm season
cluster) at first si^n of cisease
and water Created area lightly
after creating. Repeat 3 Co 4
weeks later.
Issued: 10-31-85
11-056502-32
159
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i-.-j-'.r ...i • EPA Index to Pesticide Chemicals
-;,•,;:.->• ;-!k ^PENTACHLORONITROBENZENE
Discing q'f Registered Pesticide Produc ts.-.by Formulation
&09-,.0u01 94!. technical chemical
pentachloronitrobenzene (056502)
000524-00122*
*currently unavailable for review
&9y5.0001 95-c technical chemical
pentachloronitrobenzene (03b5U2)
005481-00197
&096.0001 962 technical chemical
pentachloronitrobenzene (056502)
000400-00401
4097.0001 971 technical chemical
pentachloronitrobenzene (056502)
002749-00009
&080.0002 80% formulation intermediate
pentachloronitrobenzene (056502)
007501-00045
&090.0002 90% formulation intermediate
pentachloronitrobenzene (056502)
000400-00414
&010.0003 102 dust
pentachloronitrobenzene (056502) plus p-(dimethylaraino)benzenediazo
sodium sulfonate (034201)
003125-00145
pentachloronitrobenzene (056502) plus thiram (07y801)
0023*2-00786 0037*3-00303
pentachloronitrobenzene (056502) plus captan (081301)
000239-02382*
*currently unavailable for review
pentachloronicrobenzene (0565U2) plus 5-ethoxy-3-(trichloromethyl)-
1,2,4-thiadiazole (084701)
007501-000*7 007501-OOU52
pentachloronitrobenzene (056502), maneb (014505), captan (081301) plus
5-ethoxy-3-(trichloromethyl)-l,2,4-thiadiazole (084701)
- 050200-00002
&020.0003 20t dust
pentachloronitrobenzene (056502) plus 5-ethoxy-3-(trichloromethyl)-
1,2,4-thiadiazole (084701)
007501-00048 007501-00051 007501-00054
Issued: 10-31-85
11-056502-33
160
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&025.0003
EPA Index Co Pesticide Chemicals
PENTACHLORONITROBENZENE
Listing of Registered Pesticide Products by Formulation (continued)
25% dust
pentachloronitrobenzene (0565U2)
034704-00044
&030.0003 30% dust
pentachloronitrobenzene Cu5b502) plus thirarr. (0798U1)
0037*3-00300
pentachloronitrobenzene (056502) plus captan (081301)
000476-01977 002749-00289 010107-00081
4040.0003 40? dust
pentachloronitrobenzene (056502)
000279-01250
&002.0004 22 granular
pentachloronitrobenzene (056502)
000557-01856
4002.2504 2.252 granular
pentachloronitrobenzene (056502)
007001-00332
4002.5004 2.5% granular
pentachloronitrobenzene (056502) plus carbaryl (056801)
011489-00001
4003.7504 3.752 granular
pentachloronitrobenzene (056502)
004185-00229
4004.6704 4.67% granular
pentachloronitrobenzene (056502)
007401-00197 007401-00389
400 5'. 0004 51 granular
pentachloronitrobenzene (056502) plus p-(dimethylamino)benzenediazo
•odium sulfonate (034201)
003125-00109
4006.5004 6.53! granular
pentachloronitrobenzene (056502) plus 0,0-diethyl S-(2-(ethylthio)-
ethyl] phosphorodithioate (032501)
000400-00411* 001202-00203* 001526-00411 002935-00362
008434-00033 010226-00014*
^suspended
*currently unavailable for review
Issued: 10-31-85
11-056502-34
161
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EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Listing of Registered Pesticide Products by Formulation (continued)
6.5~ granular (continued)
pentachloronitrobenzene (056502) plus phorate (057201)
000279-02938 000^00-00^12 001526-00*92* 002935-00361
011656-00029
*currently unavailable for review
pentachloronitrobenzene (056502), 0,0-diethyl S-[2-(ethylthio)ethyl]
phosphorodithioate (032501) plus 5-ethoxy-3-(trichlorooethyl)-l,2,4-
thiadiazole (084701)
000400-00408*
*currently unavailable for review
pentachloronitrobenzene (056502), phorate (057201) plus 5-ethoxy-3-(tri-
chloromethyl)-l,2,4-thiadiazole (084701)
000241-00187 000279-02591 000400-00409
4009.9504 9.952 granular
pentachloronitrobenzene (056502)
000538-00116
4010.0004 10% granular
pentachloronitrobenzene (0565U2)
000400-00402 000400-00407 000^76-01739 001202-00193
001526-00439 002935-00357 010404-00038
pentachloronitrobenzene (056502) plus captan (081301)
000476-01881
pentachloronitrobenzene (056502) plus 5-ethoxy-3-(trichloromethyl)-
1,2,4-thiadiazole (084701)
000400-00406
pentachloronitrobenzene (056502), phorate (057201) plus 5-ethoxy-3-(tri-
chloromethyl)-l,2,4-thiadiazole (084701)
000241-00146
pentachloronitrobenzene (056502), 5-ethoxy-3-(trichloromethyl)-l,2,4-
thiadiazole (084701) plus aldicarb (098301)
000264-00319
4012.5004 12.51 granular
pentachloronitrobenzene (056502)
010404-00037
4013.5704 13.571 granular
pentachloronitrobenzene (056502)
000538-00170
Issued: 10-31-85 11-056502-35
162
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EPA-Index to Pesticide Chemicals
PENTACHLORON1TROBENZENE
Listing of Registered Pesticide Products by Formulation (continued)
&015.40CK 15.^?. granular
pentachloronitrobenzene (056502)
000538-00040 000538-00050 000538-00055 000538-00108
&016.9U04 16.9% granular
pentacnloronitrobenzene tU3o50.:)
000538-00070 000538-0009b
4030.0004 302 granular
pentachloronitrobenzene (056502)
000400-00415
4014.0006 142 vettable powder
pentachloronitrobenzene (056502), thirara (079801) plus captan (081301)
006720-00075
4030.0006 30% wet table powder
pentachloronitrobenzene (056502) plus captan (081301)
000476-01928
4035.0006 352 wet table powder
pentachloronitrobenzene (056502) plus p-(dimethylamino)benzenediazo
sodium sulfonate (034201)
005967-00055 003125-00070
4075.0006 752 wettable powder
pentachloronitrobenzene (056502)
000400-00399 003743-00251
pentachloronitrobenzene (056502) plus cycloheximide (043401)
045639-00103*
^currently unavailable for review
4212.5012 12.5& (1.056 Ib/gal) emulsifiable concentrate
pentachloronitrobenzene (056502) plus malathion (057701)
007401-00163
4222.9012 22.91 (2 Ib/gal) eaulsifiable concentrate
pentachloronitrobenzene (056502) plus 5-ethoxy-3-(trichlororoethyl)-
1,2,4-thiadiazole (084701)
007501-00046
4223.2012 23.21 (2 lb/g«l) cmulsifiable concentrate
pentachloronitrobenzene (056502) plus 5-ethoxy-3-(trichloromethy 1) -
1,2,4-thiadiazole (084701)
007501-00049 043789-00095
4223.4012 23.4* (2 Ib/gal) emul«ifiable concentrate
pentachloronitrobenzene (056502)
001339-00187
Issued: 10-31-85
11-056502-36
163
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EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Listing of Registered Pesticide Products by Formulation (continued)
6223.6012 23.8* (2 Ib.'gal) emulsifiable concentrate
pentachloronitrobenzene (056502)
000400-00400
&223.9012 23.9% emulsifiable concentrate
pentachloronitrobenzene(05o502)
010370-00070*
*currently unavailable for review
4224.0012
&224.0012
4224.7012
&226.4912
&217.001;
&210.0016
6217.6816
4220.0016
24Z (2 Ib/gal) emulsifiable concentrate
pentachloronitrobenzene (056502;
000400-00403 000400-00404 000550-00091
000557-01936 000728-00081 002935-00208
007001-00175 007401-00042 007501-00050
010820-00004 043789-00097 046946-00170
000554-00110
002935-00419
007501-00053
pentachloronitrobenzene (056502) plus xylene (086802)
043789-00096
24% (2.05 Ib/gal) emulsifiable concentrate
pentachloronitrobenzene(056502)
007u01-00084
24.7% (2.055 Ib/gal) emulsifiable concentrate
pentachloronitrobenzene (056502)
010820-00007
2J6.49% (2 Ib/gal) emulsif iable concentrate
pentachloronitrobenzene (056502)
010226-OOU32
17% (1.68 Ib/gal) flowable concentrate
pentachloronitrobenzene (05b502) plus carboxin (090201)
007501-00087
IQl (0.88 Ib/gal) liquid-ready to use
pentachloronitrobenzene (056502) plus 5-ethoxy-3-(trichloromethyl''-
1,2,4-thiadiazole (08-^701)
007501-00058
17.681 (1.68 Ib/gal) liquid-ready to use
pentachloronitrobenzene (056502) plus lindane (garana isomer of benzene
hexachloride (009001)
007501-00078
20% (1.72 lb/g«l) liquid-ready to use,
pentachloronitrobenzeae (056502)
007501-00061
Issued: 10-31-85
11-056502-37
164
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EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Listing of Registered Pesticide Products by Formulation (continued)
ili;O.OUlo 20/. (1.80 Ib/gal) liquid-ready to use
pentachloronitrobenzene (0565U2) plus 5-ethoxy-3-(trichloromethyl)-
1,2,4-thiadiazole (064701)
007501-00059
6 2 I U. 001& 2U'- (1. 8v Ib/gal) liquid-ready to use
pentachloronitrobenzene (03&502) plus 5-ethoxy-3-(trichloromethy!)•
1,2,4-thiadiazole (084701)
007501-00060
&222.6016 22.6Z (2 Ib/gal) liquid-ready to use
pentachloronitrobenzene (056502) plus 5-ethoxy-3-(trichloromethyl)-
1,2,4-thiadiazole (084701)
007501-00056
&223.1016 23". U (2 Ib/gal) liquid-ready to use
pentachloronitrobenzene (056502) plus 5-ethoxy-3-(trichloromethyl)-
1,2,4-thiadiazole (084701)
007501-00057
&223.2016 23.2% (2 Ib/gal) liquid-ready to use
pentachloronitrobenzene (056502) plus 5-ethoxy-3-(trichloromethyl)-
1,2,4-thiadiazole (084701)
000400-00^05
4223.7016 23.71 (2 Ib/gal) liquid-ready to use
pentachloronitrobenzene (056502)
007501-00055
&224.0016 24% (2.23 Ib/gal) liquid-ready to use
pentachloronitrobenzene (056502)
007501-00070
4225.0016 25% (2 Ib/gal) liquid-ready to use
pentachloronitrobenzene (056502)
010912-00024
Issued: 10-31-85
11-056502-38
165
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9999*99
EPA Index to Pesticide Chemicals
PENTACHLORONITROB.ENZENE
i
Listing of Registered Pesticide Products by Formulation (continued)
State Label Registrations
AL Reg. No.
000359-08633
A2 Reg. No.
001202-05009
CA Reg. No.
000239-08631
001202-05035
008434-07052
010972-06550
011093-07371
FL Reg. No.
000557-06962
006720-03357
021275-05364
GA Reg. No.
000359-0bo32
ID Reg No.
010258-08637
OK Reg. No.
001258-06634
OR Reg. No.
001871-08921
TX Reg. No.
001258-08636
001258-08639
001526-U3787
000909-08642
001202-05061
008434-07053
010972-10158
011656-05918
000829-09450
007478-08028
001202-05033
005967-08641
008434-07054
010972-10159
011656-07055
003122-07192
009859-10165
OU125b-08b3o 007413-010284
001258-08635 001258-08640
001202-05034
008278-10167
008434-08976
011017-08196
003122-07565
009859-10166
035994-06087 037854-08298
Issued: 10-31-85
11-056502-39
166
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Listing of
Chemical
Code
098301
081301
090201
043401
032501
057201
034201
084701
009001
057701
014505
079S01
086802
EPA Index to Pesticide Chemicals
PENTACHLORONITROBENZENE
Appendix A-l
the Active Ingredients) Found in Combination With the Report Che-
Common Name
(source)
cycloheximi.de
disulfoton (ISO)
phorate (ANSI)
fenaminosulf (ISO)
lindane
EPA Acceptable
Common/Chemical Name
aldicarb
captan
carboxin
cycloheximide
3-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyeth
yllglutarimide
o,o-diethyl s-[2-(ethylthio)ethyl]
phosphorodiathioate
o,o-diethyl •-((ethylthio)methylJ
phosphorodithioate
p-(dimethylamino)benzenediazo sodium sulfonate
5-ethoxy-3-(trichloromethyl)-l,2,4-thiodiazole
lindane
malathion
maneb
Chiram
xylene
— Use EPA Acceptable Cotnmon/Cheiuical Name
1
Issued: 10-31-85
11-056502-40
167
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IV. BIBLIOGRAPHY APPENDICES
Guide to Bibliography
Bibliography
168
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BIBGUIDE-1
GUIDE TO USE OP THIS BIBLIOGRAPHY
PCNB
CONTENT OP BIBLIOGRAPHY. This bibliography contains
citations of all studies considered relevant by EPA in
arriving at the positions and conclusions stated elsewhere
in the Standard. Primary sources for studies in this
bibliography have been the body of data submitted to EPA
and its predecessor agencies in support of past regulatory
decisions. Selections from other sources including the
published literature, in those instances where they have
been considered, will be included.
UNITS OP ENTRY. The unit of entry in this bibliography
is called a "study." In the case of published materials,
this corresponds closely to an article. In the case of
unpublished materials submitted to the Agency, the Agency
has sought to identify documents at a level parallel to
the published article from within the typically larger
volumes in which they were submitted. The resulting
"studies" generally have a distinct title (or at least a
single subject), can stand alone for purposes of review,
and can be described with a conventional bibliographic
citation. The Agency has attempted also to unite basic
documents and commentaries upon them, treating them as a
single study.
IDENTIFICATION OP ENTRIES. The entries in this bibliography
are sorted numerically by "Master Record Identifier," or
MRID, number. This number is unique to the citation, and
should be used at any time specific reference is required.
It is not related to the six-digit "Accession Number"
which has been used to identify volumes of submitted
studies; see paragraph Md)(4) below for a further explana-
tion. In a few cases, entries added to the bibliography
late in the review may be preceded by a nine-character
temporary identifier. These entries are listed after
all MRID entries. This temporary identifier number is
also to be used whenever specific reference is needed.
FORM OP ENTRY. In addition to the Master Record Identifier
(MRID), each entry consists of a citation containing
wtandard elements followed, In the case of material
submitted to EPA, by a description of the earliest known
submission. Bibliographic conventions used reflect the
standards of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
169
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BIBGUIDE-2
a. Author. Whenever the Agency could confidently identify
one, the Agency has chosen to show a personal author.
When no individual was identified, the Agency has
shown an identifiable laboratory or testing facility
as author. As a last resort, the Agency has shown
the first submitter as author.
b. Document Date. When the date appears as four digits
with no question marks, the Agency took it directly
from the document. When a four-digit date is followed
by a question mark, the bibliographer deduced the
date from evidence in the document. When the date
appears as (19??), the Agency was unable to determine
or estimate the date of the document.
c. Title. In some cases, it has been necessary for
Agency bibliographers to create or enhance a document
title. Any such editorial insertions are contained
between square brackets.
d. Trailing Parentheses. For studies submitted to the
Agency in the past, the trailing parentheses include
(in addition to any self-explanatory text) the fol-
lowing elements describing the earliest known submission:
(1) Submission Date. The date of the earliest known
submission appears immediately following the word
"received."
(2) Administrative Number. The next element,
immediately following the word "under," is the
registration number, experimental use permit
number, petition number, or other administrative
number associated with the earliest known submission.
(3) Submitter. The third element is the submitter,
following the phrase "submitted by." When
authorship is defaulted to the submitter, this
element is omitted.
(4) Volume Identification (Accession Numbers). The
final element in the trailing parentheses
identifies the EPA accession number of the volume
in which the original submission of the study
appears. The six-digit accession number follows
the symbol "CDL," standing for "Company Data
Library." This accession number is in turn
followed by an alphabetic suffix which shows the
relative position of the study within the volume.
For example, within accession number 123456, the
first study would be 123456-A; the second, 123456-
B; the 26th, 123456-Z; and the 27th, 123456-AA.
170
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCBN Standard
MRID CITATION
00001555 Larson, P.S.; Borzelleca, J.F. (1967) Acute Oral Toxicities and
Potentiation Studies of Terraclor and Terrazole in Male Albino
Rats. (Unpublished study received Nov 30, 1967 under 1258-Q;
prepared by Medical College of Virginia, Dept. of Pharmacology,
submitted by Olin Mathieson Chemical Corp., Stamford, Conn.;
CDL:110044-A)
00001570 Griffith, W.P. (1973) Determination of Terrazole (5-Ethoxy-3-
Trichloromethyl-l,2,4-Thiadiazole) and Terraclor (Penta-
chloronitrobenzene) and Allied Metabolites in Plant Tissues or
Harvest Samples. Method CAM-24-73 dated Jul 3, 1973. (Unpub-
lished study received Feb 4, 1977 under 1258-812; submitted by
Olin Corp., Agricultural Div., Little Rock, Ark.; CDL:095799-M)
00001665 Finnegan, J.K.; Larson, P.S.; Smith, R.B., Jr.; Haag, H.B.;
Hennigar, G.R. (1958) Acute and chronic toxicity studies on pen-
tachloronitrobenzene. Archives Internationales de Pharmacody-
namie et de Therapie CXIV(l):38-52. (Also in unpublished sub-
mission received Jan 26, 1969 under 9F0754; submitted by Olin
Mathieson Chemical Corp., New York, N.Y.; CDL:091301-A)
00001666 Larson, P.S.; Borzelleca, J.F. (1968) Three Generation Reproduction
Study on Rats Receiving Terraclor in Their Diet. (Unpublished
study including letter dated May 15, 1968 from G.R. Hennigar to
Paul Larson, received Jan. 26, 1969 under 9F0754; prepared by
Medical College of Virginia, Dept. of Pharmacology, Submitted by
Olin Mathieson Chemical Corp., New York, N.Y.; CDL:091301-B)
00001668 Larson, P.S.; Borzelleca, J.F. (1968) Acute Percutaneous Toxicity
of Terraclor in Male Albino Rabbits. (Unpublished study
including letter dated Aug 21, 1968 from P.S. Larson to
Richard F. Philpitt, received Jan 26, 1969 under 9F0754; pre-
pared by Medical College of Virginia, Dept. of Pharmacology,
submitted by Olin Mathieson Chemical Corp., New York, N.Y.;
CDL:091301-H)
00001669 Ackermann, H.J.; Baltrush, H.A.; Berges, H.H.; Brookover, D.O.;
Brown, B.B. (1958) Spectrophotometric determination of penta-
chloronitrobenzene on food £nd forage crops: Fungicide residues.
Agricultural and Food Chemistry 6(10):747-750. (Also in unpub-
lished submission received Jan 26, 1969 under 9F0754; submitted
by Olin Mathieson Chemical Corp., New York, N.Y. CDL:091301-I)
171
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MRID CITATION
00001670 Methratta, T.P.; Montagna, R.W.; Griffith, W.P. (1967) Determin-
ation of Terraclor in crops and soil by electron-capture gas
chromatography. Agricultural and Food Chemistry 15(4):648-650.
(Also in unpublished submission received Jan 26, 1969 under
9F0754; submitted by 01 in Mathieson Chemical Corp., New York,
N.Y.; CDL:091301-J-)'
00001678 Betts, J.J.; James, S.P.; Thorpe, W.V. (1955) The metabolism of
pentachloronitrobenzene and 2:3:4:6-tetrochloronitrobenzene and
the formation of mercapturic acids in the rabbit. Biochemical
Journal 61(?):611-617. (Also in unpublished submission received
Jan 26, 1969 under 9F0754; submitted by Olin Mathieson Chemical
Corp., New York, N.Y.; CDL:091301-S)
00001679 Lambe, R.C. (1973) Pyracantha (Pyracantha leylandii) Scab:
Fusicaldium pyracanthae. (Unpublished study including let-
ter dated Jul 3, 1973 from R.C. Lambe to W.A. Small, received
Oct 1, 1973 under 372-EX-9; prepared by Virginia Polytechnic
Institute and State Univ., Dept. of Plant Pathology and Physio-
logy, submitted by Mallinckrodt Chemical Works, St. Louis, Mo.;
CDL:123407-A)
00001704 Langston, R.; Van Schaik, B. (1968?) Residue Analyses of Some
Edible Crops Grown in Soils Treated with Carbon-14 Labeled
Pentachloronitrobenzene. Undated Method. (Journal Paper No.
972; unpublished study received Feb 16, 1968 under 1258-60(818);
prepared by Purdue Univ.—Layfayette, Agricultural Experiment
Station, submitted by Olin Mathieson Chemical Corp., New Haven,
Conn.; COL:101585-F)
00001707 Kuchar, E.J. (1969) Residues of Terraclor (Pentachloronitrobenzene-
PCNB) In Alfalfa: CASR-7-69. (Unpublished study that includes
Method CAM-14-69 dated Nov 25, 1969 entitled: Determination of
Pentachloronitrobenzene (PCNB, Olin 5275) in Alfalfa: Analytical
Method, received Mar 24, 1970 under 9F0754; submitted by Olin
Mathieson Chemical Corp., New Haven, Conn.; CDL:091299-C)
00001859 Kuchar, E.J. (1973) Miscellaneous Analytical Investigations Con-
cerned with Terraclor: CASR-3-73. (Unpublished study received
Jul 31, 1972 under 1F1083; submitted by Olin Corp., Stamford,
Conn.; CDL:090841-I)
00001861 Kuchar, E.J. (1973) Residues of Terraclor, Impurities and Metabo-
lites in Various Crops (1969-1972): CASR-2-73. (Unpublished
study that includes method CAM-12-70 dated Apr 28, 1970, re-
ceived Jul 31, 1972 under 1F1083; submitted by Olin Corp.,
Stamford, Conn.; CDL:090841-K)
172
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MRID CITATION
00001862 Kuchar, E.J. (1973) Residues of Terraclor, Terraclor-Super X in
Peanuts--1969, 70, 71 Crops: CASR-1-73. (Unpublished study that
includes method CAM-6-70 dated Mar 13, 1970, received Jul 31,
1972 under 1F1083; submitted by 01 in Corp., Stamford, Conn.;
CDL:090841-L)
00001870 Borzelleca, J.F.; Larson, P.S.; Crawford, E.M.; Hennigar,
G.R., Jr.; Kuchar, E.J.; Klein, H.H. (1971) Toxicologic and
metabolic studies on pentachloronitrobenzene. Toxicology and
Applied Pharmacology 18(3):522-534. (Also in unpublished sub-
mission received Jul 31, 1972 under 1F1083; submitted by Olin
Corp., Stamford, Conn.; CDL:090841-AD)
00002228 Kuchar, E.J. (1970) Residues of Terraclor-Super X in Cotton Seed:
CASR-6-70. (Unpublished study received May 28, 1970 under
OF0997; submitted by Olin Corp., Stamford, Conn.; CDL-.091717-H)
00002827 Gorbach, S.; Wagner, U. (1967) Pentachloronitrobenzene residues in
potatoes. Journal of Agriculture and Food Chemistry 15(4):654-
656. (Also in unpublished submission received Feb 16, 1968
under 1258-818; submitted by Olin Mathieson Chemical Corp.,
New Haven, Conn.; CDL:101585-G)
00014326 Kuchar, E.J.; Griffith, W.P.; Thomas, R.J. (1969) Analytical Inves-
tigations Concerned with Terraclor--Terrazole Cow Feeding Stud-
ies: CASR-4-69. (Unpublished study received on unknown date un-
der OF0997; submitted by Olin Corp., Stamford, Conn.; CDL:
098490-K)
00014327 Griffith, W.P. (1969) Determination of 5-Ethoxy-3-trichloromethyl-
1,2,4-thiadiazole (Olin 52424) and Pentachloronitrobenzene
(PCNB, 011n 5275) and Allied Metabolites in Cow's Milk. Method
CAM-1-69 dated Feb 1, 1969. (Unpublished study received on un-
known date under OF0997; submitted by Olin Corp., Stamford,
Conn.; COL:098490-L)
00028427 Thomas, R.J.; Venezia, P.M.; lacoviello, S.A. (1980) Residues of
Terrazole..., Terraclor..., Impurities and Metabolites in
Cotton Seed, 1979: CASR-4-80. (Unpublished study received
Feb 20, 1980 under 1258-EX-12; submitted by Olin Corp., Stam-
ford. Conn.; COL:241820-A)
00028428 Olin Corporation (1972) Determination of Terraclor...and Ter^a-
zole...in Cotton Seed. Method CAM-11-72 dated Apr 4, 1972.
(Unpublished study received Feb 20, 1980 under 1258-EX-12; CDL:
241820-B)
173
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MRID CITATION
00031296 Rushing, K.W.; Slagowski, J.L.; Westberg, G.L. (1977) Residue Chem-
istry Data To Support the Use of Ortho Difolatan-PCNB 45-25 Seed
Protectant for Peanuts: Summary. (Unpublished study received
Apr 8, 1980 under 239-2480; prepared in cooperation with Morse
Laboratories, Inc., submitted by Chevron Chemical Co., Richmond,
Calif.; CDL:242303-A)
00053075 Chemagro Corporation (1960) Synopsis of Pentachloronitrobenzene
(PCNB) Analytical and Residue Data (Sugar Beets). (Unpublished
study received Apr 4, 1960 under unknown admin, no.; prepared in
cooperation with 01 in Mathieson Chemical Corp.; CDL:119239-A)
00059120 Thomas, M.P. (1965) Letter sent to S.I. Cohen dated Jun 11, 1965:
Storage stability of Olin-2424 and Terraclor in cottonseed.
(Unpublished study received May 28, 1970 under OF0997; submitted
by 01 in Chemicals, Consumer Products, Div. of 01 in Corp., Stam-
ford, Conn.; CDL:091717-AF)
00059146 Kuchar, E.J. (1968) Letter sent to H.H. Klein dated Feb 2, 1968:
Residues—seed treatment samples. (Unpublished study received
Feb 16, 1968 under 1258-818; submitted by 01 in Corp., Stamford,
Conn.; CDL:101585-K)
00059149 Sisken, H.R. (1967).Letter sent to H.H. Klein dated'May 3, 1967:
PCNB and 2424 residue in green lima beans. (Unpublished study
received Feb 16, 1968 under 1258-818; submitted by 01 in Corp.,
Stamford, Conn.; CDL:101585-Q)
00059155 Kuchar, E.J. (1968) Letter sent to H.H. Klein dated Feb 7, 1968:
Residues—seed treatment. (Unpublished study received Feb 16,
1968 under 1258-818; submitted by 01 in Corp., Stamford, Conn.;
COL:101585-Z)
00059932 Kuchar, E.J. (1970) Letter sent to H.H. Klein dated Oct 14, 1970:
Terraclor experiments—peanut related material. (Unpublished
study received Jul 31, 1972 under 1F1083; submitted by 01 in
Chemicals, Consumer Products, Div. of 01 in Corp., Stamford,
Conn.; CDL:090841-F)
00059933 Kuchar, E.J. (1973) Letter sent to R.F. Philpitt dated Jan 23,
1973: Terraclor residues—Idaho potatoes. (Unpublished study
received Feb 5, 1973 under 1F1083; submitted by Olin Chemicals,
Consumer Products, Div. of Olin Corp., Stamford, Conn.; CDL:
090841-G)
174
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MRID CITATION
00060561 Shipp, M.J.; Young, J.A. (1975) Acute Toxicity and Irritation
Studies of Product PD-128: Report No. 75-671-21. (Unpublished
study received Feb 13, 1976 under 5741-15; prepared by Hill Top
Testing Services, Inc., submitted by Spartan Chemical Co., To-
ledo, Ohio; CDL:230163-A)
00060784 Kuchar, E.J. (1969) Letter sent to H.H. Klein dated Jul 29, 1969:
Planter's peanut oil--Terraclor content. (Unpublished study
received Mar 24, 1970 under 9F0754; submitted by 01 in Mathieson
Chen. Corp., New York, N.Y.; CDL:091299-M)
00064194 01 in Corporation (1972) Residues of Terraclor-Super X in Cotton
Seed--1971 Crop: CASR-7-72. (Unpublished study received Apr 19,
1972 under OF0997; CDL:111184-A)
00064197 Thomas, M.P. (1964) Determination of 5-Ethoxy-3-trichloromethyl-
1,2,4-thiadiazole (01 in 2424) and Pentachloronitrobenzene (PCNB,
01 in 275) in Cottonseed. Method no. CAM-18-64 dated Jun 12,
1964. (Unpublished study received Apr 19, 1972 under OF0997;
submitted by Olin Corp., Stamford, Conn.; CDL:111184-E)
00071342 Rittenhouse, J.R. (1980) The Eye Irritation Potential of Hornet &
Wasp Jet Killer (CC9628): SOCAL 1549/36:106 (S-1677). (Unpub-
lished study received Feb 2, 1981 under 239-2390; submitted by
Chevron Chemical Co., Richmond, Calif.; CDL:244218-E)
00097715 Olin Corporation (1965) Terraclor Residue Data on Celery and
Lettuce. (Compilation; unpublished study received Jun 28,
1965 under 1258-185; CDL:024655-A)
00097719 Thomas, M.P.; Geenty. F.O.; Griffith, W.P. (1964) Terraclor Res-
idues in 1964 Potatoes from 2-1b. EC Treatment: CASR-31-64.
(Unpublished study received Dec 16, 1964 under 1258-279; sub-
mitted by Olin Corp., Stamford, Conn.; CDL:024735-B)
00097720 Baltrush, H.A. (1956) Method of Analysis of Terraclor in Cabbage.
(Unpublished study received Feb 23, 1956 under 1258-279; sub-
mitted by Olin Corp., Stamford, Conn.; CDL:024737-A)
00097733 Olin Corporation (1965) Terraclor Residues on Strawberries.
(Compilation; unpublished study received Jan 26, 1969 under
9F0754; CDL:091300-B)
00097734 Olin Corporation (1967) PCNB and 2424 Residues on Various Crops.
(Compilation; unpublished study received Jan 26, 1969 under
9F0754; CDL:091300-C)
175
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MR ID CITATION
00097735 Ackermann, H.J.; Minnick, E.J. (1956) Traces of Pentachloronitro-
benzene Analyses in Bell Peppers. Interim analytical rept.
(Unpublished study received Jan 26, 1969 under 9F0754; submitted
by 01 in Corp., Stamford, Conn.; CDL:091300-E)
00097736 Baltrush, H.A. (1956) Analysis for Terraclor in Cabbage and Broc-
coli: Submitter Report No. ACD-21-56. (Unpublished study
received Jan 26, 1969 under 9F0754; prepared by Purdue Univ.,
Agricultural Experiment Station, submitted by Olin Corp.,
Stamford,'Conn.; CDL:091300-F)
00097738 Olin Corporation (1969) Residue Studies of Terraclor in Forage
Crops. (Compilation; unpublished study, including report nos.
ACD-15-56 and CASR-7-69, received Jan 26, 1969 under 9F0754;
CDL:091300-I)
00097739 Olin Corporation (1965) Celery: (Residue Studies of Terrachlor).
(Compilation; unpublished study received Jan 26, 1969 under
9F0754; CDL:091300-J)
00097740 Olin Corporation (1964) Residue Studies of Terraclor on Cotton.
(Compilation; unpublished study, including report nos. ACD-19-
56 and CASR-18-64, received Jan 26, 1969 under 9F0754; CDL:
091300-K)
00097741 Olin Corporation (1969) Residue Studies of Terraclor on Peanuts.
(Compilation; unpublished study, including report nos. ACD-54-
58 and CASR-4-65, received Jan 26, 1980 under 9F0754; CDL:
091300-L)
00097742 Olin Corporation (1967) Residue Studies of Terraclor on Potatoes.
(Compilation; unpublished study, including report nos. ACD-4-55,
ACD-14-56, CASR-17-64..., received Jan 26, 1969 under 9F0754;
CDL:091300-M)
00097743 Ackermann, H.J.; Brookover, D.O.; McTurck, M.A. (1956) Analysis
for Terraclor in Tomatoes: Report No. ACD-31-56. (Unpublished
study received Jan 26, 1969 under 9F0754; submitted by Olin
Corp., Stamford, Conn.; CDL:091300-N)
00097749 Olin Corporation (1961) Introduction: White Banana Paste 9362.
(Unpublished study received May 27, 1968 under 9F0754; CDL:
093066-A)
00097751 Kuchar, E.J.; Griffith, W.P.; (1968) Analytical Studies of the
Metabolism of Terraclor in Beagle Dogs and Rats: CASR-9-68.
(Unpublished study received Sep 25, 1968 under 9F0754; sub-
mitted by Olin Corp., Stamford, Conn.; COV.097472-A)
176
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MR ID CITATION
00097757 Kuchar, E.J.; Griffith, W.P. (1975) Analytical Investigations
Concerned with Feeding Terraclor to Chickens: CASR-8-75.
(Unpublished study received Nov 17, 1975 under OF1083; sub-
mitted by 01 in Corp., Stamford, Conn.; CDL:097596-A)
00097764 Ackermann, H.J.; Minnick, E.J.; Curtis, J.A. (1954) Pentachloroni-
trobenzene Residue Analysis: A-9.01 Interim Analytical Report.
(Unpublished study received Jul 20, 1954 under 1258-158; pre-
pared by Mathieson Chemical Corp., submitted by 01 in Corp.,
Stamford, Conn.; CDL:101581-A)
00097786 01 in Mathieson Chemical Corporation (1956) Method for Analysis of
Terraclor in Garlic. (Unpublished study received on unknown
date under unknown admin, no.; CDL:119241-A)
00097791 01 in Corporation (1958) Methods of Extraction, Clean-up and Analy-
ses of Terraclor Residues in Peanut Kernels, Shells and Hay.
(Compilation; unpublished study received Mar 14, 1958 under
unknown admin, no.; CDL:119260-A)
00097800 O'Grodnick, J.S. (1979) Identification of the Polar Metabolites of
14C-PCNB after Oral Administration to Rats: Report No. 78054.
(Unpublished study received Jul 6, 1979 under 1258-517; prepared
by Bio/dynamics, Inc., submitted by 01 in Corp., Stamford, Conn.;
CDL:238772-A)
00097801 01 in Corporation (1954) Analysis of Terraclor Residues in Bell
Peppers from Cockeysville, Maryland, Pleasant Hill Farm. (Un-
published study received Feb 14, 1957 under unknown admin, no.;
CDL:223052-B)
00103131 Thomas, R.; Burger, R.; lacoviello', S.; et al. (1980) Residues of
Terrazole ... and Metabolites ... in Peanut Kernals and Shells
(1975 and 1977 Crops): CASR-10-80. (Unpublished study received
Jun 8, 1982 under 1258-740; submitted by 01 in Corp., Stamford,
CT; CDL:070901-A)
00106632 MacBride, J. (1961) Banana Paste Blanco as a Fungicide for Treat-
ing Banana Stems: Report No. 1060. (Unpublished study received
Jan 11, 1961 under unknown admin, no.; submitted by W.R. Grace
& Co., Memphis, TN; COL:119357-A)
177
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MR ID CITATION
00109402 Ciba-Geigy Corp. (1981) Metalaxyl—Cotton In-furrow Applications of
Ridomil 2E and 5G Including Mixtures with PCNB: Report No. ABR-
81046. (Compilation; unpublished study received Jul 28, 1982
under 100-607; CDL:247934-A)
00109656 Dunn, J.; Bush, P.; Booth, N.; et al. (1979) Effect of pentachloro-
nitrobenzene upon egg production, hatchability, and residue
accumulation in the tissues of white leghorn hens. Toxicology
and Applied Pharmacology 48:425-433. (Submitter 3562; also in
unpublished submission received Aug 11, 1982 under 1258-517;
submitted by 01 in Corp., Stamford, CT; CDL:071045-D)
00114164 Fletcher, D. (1973) Report to 01 in Corporation: 8-day Dietary LC50
Study with Terraclor in Bobwhite Quail: IBT No. 651-02932; 3645.
(Unpublished study received Sep 7, 1982 under 1258-517; prepared
by Industrial Bio-Test Laboratories, Inc., submitted by Olin
Corp., Stamford, CT; CDL:248280-F)'
00114165 Fletcher, D. (1973) Report to Olin Corporation: 8-day Dietary LC50
Study with Terraclor in Mallard Ducklings: IBT No. 651-02931;
3646. (Unpublished study received Sep 7, 1982 under 1258-517;
prepared by Industrial Bio-Test Laboratories, Inc., submitted by
Olin Corp., Stamford, CT; CDL:248280-G)
00114167 EG & G Bionomics (1982) Acute Toxicity of Terraclor to the Water
Flea ...: Bionomics Report IBW-82-5-1170; 3761. (Unpublished
study received Sep 7, 1982 under 1258-517; submitted by Olin
Corp., Stamford, CT; CDL:248280-1)
00114168 lacoviello, S. (1978) Chemodynamic Parameter of Terraclor (Penta-
chloronitrobenzene) Soil Adsorption: 1414. (Unpublished study
received Sep 7, 1982 under 1258-517; submitted by Olin Corp.,
Stamford, CT; CDL:248281-A) '
00114181 Esposlto, A.; DeFelice, D.; Kuchar, E.; et al. (1977) Laboratory
Soil Leaching Studies Concerned with Terraclor (Pentachlor-
nitrobenzene): 3450. (Unpublished study received Sep 7, 1982
under 1258-517; submitted by Olin Corp., Stamford, CT; CDL:
248281-P)
00114183 Begum, S.; Scheunert, I.; Hague, A.; et al. (1979) Conversion of
14C pentachlorom'trobenzene in onions. Pesticide Biochemistry
and Physiology 11:189-200. (Submitter 3512; also in unpublished
submission received Sep 7, 1982 under 1258-517; submitted by
Olin Corp., Stamford, CT; COL:248282-B)
178
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MR ID CITATION
00114184 01 in Corp. (1980) PCNB Metabolism in Peanuts. (Compilation of
reports by U.S. Dept. of Agriculture, Science and Education
Administration, Agricultural Research, Metabolism and Radiation
Research Laboratory; unpublished study; CDL:248282-C)
00114185 Lamoureux, G.; Rusness/D. (1980?) In vitro Metabolism of Penta-
chloronitrobenzene to Pentachloromethylthiobenzene by Onion:
Characterization of Gluthione S-Transferase, Cysteine C-S Lyase,
and S-Adenosylmethionine Methyl Transferase Activities: 01 in
3549. (U.S. Dept. of Agriculture, Science and Education Ad-
ministration, Agricultural Research, Metabolism and Radiation
Research Laboratory; unpublished study; CDL:248282-D)
00114186 Lamoureux, G.; Rusness, D. (1979?) Catabolism of Glutathione Con-
jugates of Pesticides in Higher Plants: Olin 3550. (U.S.
Dept. of Agriculture, Science and Education Administration,
Agricultural Research, Metabolism and Radiation Research Labora-
tory; unpublished study; CDL:248282-E)
00114187 Okazaki, H. (1979) Formation of methyl pentachlorophenyl sulfoxide
and sulfone from pentachloronitrobenzene in soil and plants.
J. Pesticide Sci. 4:355-360. (Submitter 3577; also in unpub-
lished submission received Sep 7, 1982 under 1258-517; sub-
mitted by Olin Corp., Stamford, CT; CDL-.248282-F)
00114199 Medical College of Virginia, Dept. of Pharmacology (1965?) A Study
of the Potential Teratogenic Effects of Pentachloronitrobenzene
in Rats: Submitter 1856. (Unpublished study received Sep 7,
1982 under 1258-517; submitted by Olin Corp., Stamford, CT;
CDL:248283-F)
00114201 Larson, P.; Borzelleca, J.; Hennigar, G. (1968) Toxicologic Study
on the Effect of Adding Terraclor to the Diet of Beagle Dogs
for a Period of Two Years: Submitter 2490. (Unpublished
study received Sep 7, 1982 under 1258-517; prepared by Medical
College of Virginia, Dept. of Pharmacology and Medical College
of South Carolina, submitted by Olin Corp., Stamford, CT; CDL:
248283-1)
00114203 Pal anker, A.; Goldhamer, R. (1974) Acute Inhalation Toxicity (Rat);
Ocular Irritation (Rabbit): Experimental Reference No. A-1369;
2871. Final rept. (Unpublished study received Sep 7, 1982
under 1258-517; prepared by Blometric Testing, Inc., submitted
v" Olin Corp., Stamford, CT; CDL:248283-1)
179
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OFFICE OF PESTICIDE PROGRAMS
' REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MRID CITATION
00114205 Aschbacher, P.; Feil , V. (1976) Metabolism of Pentachloronitro-
benzene in the Goat: Olin 3139. (U.S. Agricultural Research
Service, Metabolism and Radiation Research Laboratory; unpub-
lished paper presented at the Symphosium on Fate of Pesticides
in Large Animals; 172nd American Chemical Society National
Meeting, Pesticide Div.; Aug 29-Sep 3, 1976; San Francisco, CA;
unpublished study; CDL:248283-N)
00114206 Ercegovich, C.; Rashid, K. (1977) Mutagenesis Induced in Mutant
Strains of Salmonella Typhimurium by Pesticides: Submitter
3517. (Unpublished paper presented at 174th American Chemical
Society National Meeting, Div. of Pesticide Chemistry; Aug 30,
1977; unpublished study received Sep 7, 1982 under 1258-517;
prepared by Pennsylvania State Univ., Pesticide Research Labora-
tory, submitted by Olin Corp., Stamford, CT; CDL:248283-P)
00114207 Dupre, G.; O'Grodnick, J. (1978) Absorption and Elimination Char-
acteristics of 14C-labeled Pentachloronitrobenzene in Rats—
Pilot Study: Report No. 77037; 3528. (Unpublished study re-
ceived Sep 7, 1982 under 1258-517; prepared by Bio/dynamics,
Inc., submitted by Olin Corp., Stamford, CT; CDL:248284-A)
00114208 Dupre, G.; O'Grodnick, J. (1978) Characterization and Identifi-
cation of 14C-PCNB Metabolites in Rat Urine and Feces: Report
No. 77037-2; 3528. (Unpublished study received Sep 7, 1982
under 1258-517; prepared by Bio/dynamics, Inc., submitted by
Olin Corp., Stamford, CT; CDL:248284-B)
00114209 O'Grodnick, J.; Adamovics, J. (1980) The Metabolic Fate of Penta-
chloronitrobenzene--Pilot Study: Report No. 79056; 3528. (Un-
published study received Sep 7, 1982 under 1258-517; prepared
by Bio/dynamics, Inc., submitted by Olin Corp., Stamford, CT;
CDL:248284-D)
00114220 Borzelleca, J. (1974) Acute Dermal Toxicity of Pentachloronitro-
benzene in Rabbits: Submitter 3565. (Unpublished study re-
ceived Sep 7, 1982 under 1258-517; prepared by Medical College
of Virginia, MCV Station, Div. of Toxicology, submitted by Olin
Corp., Stamford, CT; CDL:248285-E)
00144222 Lamb, D.; Matzkanin, C. (1976)nThe Eye Irritancy of Croneton 40%
Wettable Powder. Unpublished Mobay study 50865. 1 p.
180
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MRID CITATION
00114224 Van der Heijden, C.; Til, H. (1974) Pentachloronitrobenzene (PCNB),
Carcinogenicity Study in Mice: Rapport Nr. R 4365; 3570. (Un-
published study received Sep 7, 1982 under 1258-517; prepared
by Centraal Instituut voor Voedingsonderzoek TNO, Neth., sub-
mitted by 01 in Corp., Stamford, CT; CDL:248285-I)
00114226.Weisburger, J.; Weisburger, E.; Powers, M.; et al. (19??) Bioassay
of pentachloronitrobenzene for possible carcinogenicity. By
U.S. National Institutes of Health, National Cancer Institute,
Division of Cancer Cause and Prevention, Carcinogenesis Testing
Program; Hazleton Laboratories America, Inc. and Tracor Jitco,
Inc. S.1.:USNIH. (DHEW Publication No. (NIH) 78-1311;
Olin 3575; published study; CDL:248285-L)
00114232 Scholz; Brunk (1968) Chronic Oral Toxicity of Pentachloronitroben-
zene: Two-year Study with Dogs: Submitter 3587. (Unpublished
study received Sep 7, 1982 under 1258-517; prepared by Farbwerke
Hoechst AG, W. Ger., submitted by Olin Corp., Stamford, CT; CDL:
248286-B)
00114233 Kogel, W.; Muller, W.; Coulston, F.; et al. (1979) Uptake, body
distribution, storage, and excretion of pentachloronitrobenzene-
14C in Rhesus monkeys. Chemosphere (2):89-95. (Submitter 3589;
also in unpublished submission received Sep 7, 1982 under 1258-
517; submitted by Olin Corp., Stamford, CT; CDL:248286-C)
00114250 Courtney, K.; Copeland, M.; Robbins, A. (1976) The effects of pen-
tachloronitrobenzene, hexachlorobenzene, and related compounds
on fetal development. Toxicology and Applied Pharmacology 35:
239-256. (Also in unpublished submission received Sep 7, 1982
under 1258-517; submitted by Olin Corp., Stamford, CT; CDL:
248286-U)
00114251 O'Grodnlck. J; Adamovics, J.; Blake, S.; et al. (1981) The metabol-
ic fate of 14C-labeled pentachloronitrobenzene in Osborne-Men-
dell rats. Chemosphere 10:67-72. (Submitter 3673; also in un-
published submission received Sep 7, 1982 under 1258-517; sub-
mitted by Olin Corp., Stamford, CT; CDL:248286-W)
00114256 Renner, G. (1980) Metabolic studies on pentachloronitrobenzene
... in rats. Xenobiotica 10(7/8):537-550. (Submitter 3698;
also In unpublished submission received Sep 7, 1982 under 1258-
517; submitted by Olin Corp., Stamford, CT; CDL:248286-AC)
181
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MRID CITATION
00114966 Dow Chemical Co. (1967) The Results of Tests on the Amount of Res-
idue Remaining, Including a Description of the Analytical Method
Used. (Compilation; unpublished study received Apr 13, 1967
under 7F0593; CDL:090764-H)
00125805 Olin Corp. (1983) Residues of Etridiazol in Peanuts. (Compilation;
unpublished study received Mar 2, 1983 under 1258-555; CDL:
071421-A)
00129446 Mitoma, C.; .Steeger, T. ; Jackson, S. ; et al . (1983) Skin Penetra-
tion Study of Olin's Terraclor Formulations in Rats: SRI Project
LSC-4675-4. Final rept. (Unpublished study received Jul 7,
1983 under 1258-517; prepared by SRI International, submitted by
Olin Corp., Stamford, CT; CDL: 250698- A)
00129447 Olin Corp. (1977) Residue of PCNB on or in Potatoes. (Compila-
tion; unpublished study received Jul 7. 1983 under 1258-517;
CDL:250699-A)
00156362 Uni royal Chemical Co. (1986) Terrachlor and Its Metabolites and Im-
purities in Processed Potatoes. Unpublished study prepared in
cooperation with Michigan State Univ. and Morse Laboratories.
27 p.
00159016 Uni royal Chemical Co. (1986) Supplemental Data: Terraclor and Its
Metabolites and Impurities in Processed Potatoes. Unpublished
study. 36 p.
05003752 Vogel, E. ; Chandler, J.L.R. (1974) Mutagenicity testing of
cyclamate and some pesticides in Drosophila melanogaster.
Experientia 30(6) :621-623.
05009139 Simmon, V.F.; Mitchell, A.D.; Jorgenson, T.A. (1977) Evaluation of
Selected Pesticides as Chemical Mutagens: In Vitro and In Vivo
Studies. Research Triangle Park, N.C.: U.S. Environmental
Protection Agency, Health Effects Research Laboratory. (EPA
report no. EPA-600/1-77-028; available from: NTIS, Springfield,
VA: PB-268 647)
'Jei'.
05010016 Bionetics Research Laboratories (1968) Evaluation of Carcinogenic,
Teratogenic, and Mutagenic Activities of Selected Pesticides
and Industrial Chemicals. Vol. I: Carcinogenic Study.
Bethesda, Md.: National Cancer Institute, Division of Cance
Cause and Prevention. (National Cancer Institute report no.
NCI-DCCP-CG-1973-1-1; available from: NTIS, Springfield, VA;
PB-223 159)
182
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the PCNB Standard
MRID CITATION
GS0128-001 01 in Corporation (1983) Residues of PCNB in Beans and Peanuts.
Unpublished report dated Jan 14, 1983. 210 p.
GS0128-002 Ackermann, H. (1960) Terraclor Residues in Strawberries.
Unpublished Memorandum to K.B. Nash dated July 25, 1960.
8 p.
GS0128-003 Dunnick, J. (1986) Toxicology and Carcinogenesis Studies of
Pentachloronitrobenzene (CAS No. 82-68-8) in B6C3F1 Mice
(Feed Studies): Board Draft: NTP TR 325. Unpublished report
dated March 26, 1986, prepared by National Toxicology Program,
Research Triangle Park, NC. 145 p.
183
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APPENDIX V
FORMS APPENDICES
184
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QMS AaerrMl No. XOO-OtfS
FIFHA SECTION 3(C)(2)(BJ SUMMARY SHEET
IP* MIGISTRATIOM NO.
PRODUCT NAMt
APPLICANTS MAMI
OATf CUIOAMCS OOCUMCNT ISSUED
Witfc roogon co m« nMjuirwiont to wfemit -|onork" dm tmoeatf bir ttM FIFRA action 3(C1(2)(I1 netin cantom* ir me rt«*fwnj
Guidance Oocwmom. I *m rvpona'ini M fto taUowitf m«wnr
D 1. I Mil mibmn d«n m * um*» mMMtf m atafy m« fallewwi^ rtfluirtmwii. It tti* un gractdura I mU urn dni4tt from (or vt not
in) rti» fltfifintion Gutdtfrnt! or m« Pfotoeait eoniwfltd m flu Rttarti of Eioon Grouft to tn« Chwnicaii Grouo. OECQ
T«IM« Proanmmo. I Moat tn« proiocoii th« I will u»:
2. I IM*« onnrod iirra in Mjr»m
ontx Th» ton ond
»u •rm ow or mort otnor r^atnrtn undtr f If HA •crwn }(C)t2}(B)di) to utirtf tnt (oiiowing d«ti
wiy rvquirM orvtocoii. wil no wOflimod to £f A fcy:
NAMC or OTMtfl HCCISTMANT
1 I onaoa t comalffttd ~C«nrfici«on of Anttnpt to Cnttr Into
rvDon TO mo foilOMftf dra no,uir*n«ntc
Afroomont wrth Offlor Nffim*mt lor Ofvtfaamtfit ol 0«n ' «»
G 4.
UH (aw o*
On.
rtffto
•t dH «n«ML (TlBI MfMB • «•< «•!••>• • VfiiOMl««»
HfOISTfUNT) AUTMQMiaO HVMUCNTATIVf
StONAHMf
OATI
185
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INTO AN AGREEMENT WITH OTHER REGISTRANTS
(To *MUfy. art* ALL f**«*ml FOR DEVELOPMENT 0* DATA
1. 1 «n duly •utftoriud to reoroMnt tfM following firmU) wfw are subject to ftM require-
ments of a Notice under PIFRA Section 3(cH2)(B) eonumw in a Guidance Document
MAMf Of PIP4M
IP* COMPANY MUM«tN
(This firm Of grouO Of firmi .« referred to Selow *i "my firm" ) |
2. My firm ii willing to O«**IOO *nd JuOmit tfit 3»U 41 rtOui'Cd by tMat Notict. it ntettury. How«»«r. my firm would orctcr TO cnttr
into in »qrc«mcnt win on* or more otn«r registrants to dtvtioo (Omtly. or to trvart m tn« eatl ot developing, tne following required
items or oata.
3. M> firn rvM ottered m writing ta tnttr xitt wcfl »" agmmtut Caowi of tit* «Hen art intrtietf. T*it after wn *te»oe«oi* ind included an oHir to ae
Muno By an artrtration daemon untfer Hf*A SextiM Ke)l2)(l)(iii] if lint ^eenftti •• at) lerwi CMi* not M rticntd ef
-------
EPA Reg. No.
PRODUCT SPECIFIC DATA REPORT
Date
Guidance Document for
Registration
Guideline No.
§158.120
PRODUCT
CHEMISTRY
61-1
bl-2
61-3
62-1
62-2
62-3
63-2
63-3
63-"
63-5
63-6
63-7
63-8
63-9
63-10
63-H
63-12
Name of Test
Identity of
Irj5redler.rs
Statement of
COEDOSlticn
Discussion of
formation of
Ingredients
Preliminary
analysis
Certification of
limits
Analytical methods
for enforcement
limits
Color
Physical state
Odor
Melting point
Boiling point
Density, bulk-
density, or
specific gravity
Solubility
Vapor pressure
Dissociation
constant
Octanol/water
partition
coefficient
pH
Test not
required
for my
product
listed
above
(check
below)
I am complying with
data requirements by
Citing MRJD
Number or
EPA Accession
Number
Submit-
ting
Data
(At-
tached)
(For EPA Use Only)
Accession Numbers
Assigned
187
-------
Registration
Guideline No.
63-13
63-14
03-15
63-16
o3-17
63-ib
03-19
o3-20
63-21
$158.135
TOXICOLOGY
81-1
81-2
81-3
81-M
81-5
81-6
Name of Test
Stability
Oxidizing/ reducing
reaction
. Flamnablllty
Explodablllty
Storage stability
Viscosity
Mlscibllity
Corrosion
characteristics
Dielectric break-
down voltage
Acute oral
toxlclty, rat
Acute dermal
toxiclty, rabbit
Acute Inhalation,
toxlcltyj rat
Primary eye
irritation, rabbit
Primary dermal
irritation
Dermal sensltlza-
tlon
Test not
required
for my
product
listed
above
(check
below)
I am complying with
data requirements by
Citing HUD
Number or
EPA Accession
Number
Submit-
ting
Data
(At-
tached)
(For EPA Use Only)
Accession Numbers
Assigned
188
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FORHULATOR'S EXEMPTION STATEMENT
(40 CFR 152.85)
EPA File Symbol/Reg. No. _____ Product Name
Applicant's Name and Address
As an authorized representative of the applicant for registration of the
product identified above, I hereby certify that:
(1) This product contains the active ingredient(s):
(2) Each active ingredient listed in paranraph (1) is oresent solely
as the result of the incorporation into the product (during formulation or
packaging) of another product which contains that active ingredient, which
is registered under FIFRA sec. 3, and which is purchased bv us from another
producer.
(3) Indicate by circling (A) or (3) below which paragraph applies:
(A) An accurate Confidential Statement of Formula (£?A Form 8570-4) for
the above identified product is attached to this statement. That formula
statement indicates, by company name, registration number and Product
name, the source of. the active ingredient(s) listed in paragcaoh (1).
OR
(8) The Confidential Statement of Formula dated on file with
the EPA is complete, current and accurate and contains the information
required on the current CSF Form No. 8570-4. The registered source(s)
of the active ingredient(s) listed in paragraph (1) is/are listed below:
Active ingredient Source; Product name and Reg. No.
Signature
Hate Title
189
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