4>EPA
            United Sutw
            Environmental Protection
            Agency
            Office of
            PwticidM and Toxic SuMmcM
            WMhington DC 20460
                                      December 1987
            PMioMM
Guidance for the
Reregistration of
Pesticide Products
Containing
Chlorpropham
as the Active Ingredient


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                                 OMB Control No. 2070-005
                                 Expires 11/89
          GUIDANCE FOR THE
REREGISTRATION OF PESTICIDE PRODUCTS

             CONTAINING

            CHLORPROPHAM
      AS THE ACTIVE INGREDIENT


         OPP NUMBER 018301

        CAS NUMBER 101-21-3

          CASE NUMBER 0271


           December 1987
    ENVIRONMENTAL PROTECTION AGENCY

    OFFICE OF PESTICIDE PROGRAMS

      WASHINGTON, D.C.  20460

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                        TABLE OF CONTENTS

 I.      Introduction	1

 II.     Chemical(s) Covered by this Standard   	  4
       A.   Description of Chemical
       B.   Use Profile 	
       C.   Chemical Structure   .  .
 III.   Agency Assessment  	  7
       A.  Summary	
       B.  Preliminary Risk Assessment
       C.  Other Science Findings  . .
       D.  Tolerance Reassessment  . .
IV.    Regulatory Position and Rationale 	 17

       A.  Regulatory Positions and Rationales ....
       B.  Criteria for Registration 	
       C.  Acceptable Ranges and Limits  	
       D.  Required Labeling 	
V.     Products Subject to this Standard	24

VI.    Requirement for Submission of Generic Data  . . 26

       A.  What are Generic Data?  	
       B.  Who Must Submit Generic Data? 	
       C.  What Generic Data Must be Submitted?  ...
       D.  How to Comply with DCI Requirements   . . .
       E.  Procedures for Requesting a Change in Protocol
       F.  Procedures for Requesting Extensions of Time
       G.  Existing Stocks Provisions Upon Suspension or
           Cancellation  	

VII.   Requirement for Submission of Product-Specific
         Data	32

VIII.  Requirement for Submission of Revised Labeling  33

IX,,    Instructions for Submission	33

       A.  Manufacturing-Use Products (Sole Active)
       B.  Manufacturing-Use Products (Multiple Active)
       C.  End-Use Products  	
       D.  Intrastate Products ...  	
       E.  Addresses	

       Glossary of Terms and Abbreviations ..... . iii

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                            APPENDICES
 I.    DATA APPENDICES
      Guide to Tables
      Table A
      Table B
 II.   LABELING APPENDICES
      Summary of Label Requirements and Table
      40 CFR 162.10 Labeling Requirements
      Physical/Chemical Hazards Labeling Statements
      Storage Instructions
      Pesticide Disposal Instructions
      Container Disposal Instructions
III.  USE INDEX APPENDIX
IV.   BIBLIOGRAPHY APPENDICES
      Guide to Bibliography
      Bibliography
V.    FORMS APPENDICES
      EPA Form 8580-1   FIFRA S3(c)(2)(B) Summary Sheet
      EPA Form 8580-6   Certification of Attempt to Enter Into
                        an Agreement with Other Registrants  for
                        Development of Data
      EPA Form 8580-4   Product-Specific Data .Report
      EPA Form 8587-27  Generic Data Exemption Statement
                                 ii

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               GLOSSARY OF TERMS AND ABBREVIATIONS

ADI:  Acceptable' Daily Intake

ai:  Active Ingredient

CAS:  Chemical Abstract System (Number)

Core Classifications:  A general guide to the acceptability of
                       data for the purpose of supporting
                       registration (invalid, supplementary,
                       minimum, or guideline).

CSF:  Confidential Statement of Formula

DNA:  deoxyribonucleic acid

EP:  End-Use Product
                                                      .*

EPA:  The Environmental Protection Agency, also "the Agency"

Epicotyl - The growing point of the embryo, which gives rise to
           the shoot, or aboveground part of the plant.

FQ, FT:  Refers to the generations in a multigeneration study.

FIFRA:  The Federal Insecticide, Fungicide, and Rodenticide Act

HOT:  Highest Dose Tested

Interim Tolerance - As per 40 CFR 180.319, interim tolerances
were formerly established for residues of various pesticides
while petitions for tolerances for negligible residues were pending
Note that negligible residue tolerances are no longer established.

LC5Q:  (median lethal concentration) a statistically derived
       concentration of a substance that can be expected to cause
       death in 50% of test animals, expressed as weight or volume
       of test substance per volume of air or water (e.g., rag/L
       or ppm).

LD5Q:  (median lethal dose) a statistically derived single dose
       that can be expected to cause death in 50% of animals when
       administered by the route indicated, expressed as weight
       of substance per unit weight of test animal  (e.g., mg/kg).

LOT:  Lowest Dose Tested

LEL:  Lowest-Effect Level
                                iii

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 MDT:   Mid  dose  tested
 MP:   Manufacturing-Use Product
 MPI:   Maximum Permissible Intake
 MRID:  Master Record Identification (Number) - EPA's system of
       tracking studies used in support of registrations.
 NPDES:  National Pollution Discharge Elimination System
 NOEL:  No-Observed-Effect Level --the maximum dose used in a test
       which produces no observed effects.
 OPP:   The Office of Pesticide Programs
 OES:   Office of Endangered Species, U.S. Fish and Wildlife Service
 PADI:  Provisional Acceptable Daily Intake --an acceptable daily
       intake of pesticide residue based on a limited data base.
 PAI:   Pure Active Ingredient
 ppm:   parts per million
 RACs:  Raw Agricultural Commodities
 Technical:  Active ingredient as manufactured
 TGAI:  Technical Grade of the Active Ingredient
 TMRC:  Theoretical Maximum Residue Contribution --an estimate of
 dietary exposure obtained by multiplying residue tolerance levels
 for a given pesticide by the average daily per capita food
 consumption figure, then adding the exposure figures for  each
crop.  TMRC is usually expressed in terms of milligrams of active
 ingredient per kilogram body weight per day.
                                 IV

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                         I.  INTRODUCTION

     EPA has established the Registration Standards  program in
order to provide an orderly mechanism by which pesticide products
containing the same active ingredient can be reviewed and standards
set for compliance with FIFRA.  The standards are applicable to
reregistration and future applications for registration of products
containing the same active ingredient.  Each registrant of a
product containing an active ingredient subject to this Standard
who wishes to continue to sell or distribute that product must
bring his product and labeling into compliance with FIFRA, as
instructed by this Standard.

     The Registration Standards program involves a thorough review
of the scientific data base underlying a pesticide's registration.
The purpose of the Agency's review is to reasses the potential
hazards arising from the currently registered uses of the pesticide;
to determine the need for additional data on health an'd environ-
mental effects; and to determine whether the pesticide meets the
"no unreasonable adverse effects" criteria of FIFRA.  In its
review EPA identifies:

     1.  Studies that are acceptable to support the data requirements
for the currently registered uses of the pesticide.

     2.  Additional studies necessary to support continued
registration.  The additional studies may not have been required
when the product was initially registered or may be needed  to
replace studies that are now considered inadequate.

     3.  Labeling revisions needed to ensure that the product  is
not misbranded and that the labeling is adequate to protect man
and the environment.

     The detailed scientific review, which  is not contained  in
this document but is available upon request1, focuses on  the
pesticide active ingredient.  The scientific review primarily
discusses the Agency's evaluation of and conclusions  from  available
data in its files pertaining to the pesticide active  ingredient.
However, during the review of these data, the Agency  is  also
looking for potential hazards that may be associated  with  the  EPs
that contain Che active ingredient.  The Agency will  apply the
provisions of this Registration Standard to  EPs  if  necessary  to
protect man and the environment.
1The scientific reviews may be obtained  from  the  Information
 Services Section, Program Management  and  Support Division
(TS-757C), EPA, 401 M St., SW., Washington,  DC  20460.

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      EPA1s  reassessment results in the development of a regulatory
 position, contained in this Registration Standard, on the pesticide
 and  each  of its  registered uses.  See Section IV - Regulatory
 Postion and Rationale.  Based on its regulatory position, the
 Agency may  prescribe a variety of steps to be taken by registrants
 to maintain their registrations in compliance with FIFRA.  These
 steps may include:

      1.   Submission of data in support of product registration;

      2.  Modification of product labels;

      3.  Modifications to the manufacturing process of the
 pesticide to reduce the levels of impurities or contaminants;

      4.  Restriction of the use of the pesticide to certified
 applicators or other specially trained individuals;
                                                      «
      5.  Modification of uses or formulation types; or

     6.  Specification of packaging limitations.

     Failure to  comply with these, requirements may result in the
 issuance of a Notice of Intent to Cancel or a Notice of Intent to
 Suspend (in the  case of failure to submit data).

     In addition, in cases in which hazards to man or the
 environment are  identified, the Agency may initiate a Special
 Review of the pesticide in accordance with Part 154 of Title 40
 of the Code of Federal Regulations (40 CFR Part 154) to examine
 in depth, the risks and benefits of use of the pesticide.  If  the
 Agency determines that the risks of the pesticide's use outweigh
 the benefits of  use, the Agency may propose additional regulatory
 actions, such as cancellation of uses of the pesticide which have
 been determined  to cause unreasonable adverse effects on the
 environment.

     EPA has authority under the Data Call-In (DCI) provisions of
 FIFRA section 3(c)(2)(B) to require that registrants submit data
 to answer our questions regarding the chemical, toxicological,
and environmental characteristics and fate of a pesticide.  This
Registration Standard lists the data EPA believes  are necessary to
resolve our concerns about this pesticide.  These  data are listed
 in the Tables A  and B in Appendix I.  Failure to  comply  with
the DCI requirements enumerated in this Registration Standard  may
result in issuance by EPA of a Notice of Intent to Suspend the
affected product registrations.

     Registrants are reminded that FIFRA section  6(a)(2) requires
them to submit factual information concerning possible unreasonable
adverse effects  of a pesticide at any time  that they become  aware
of such information.  Registrants should notify the Agency of  any

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information, including interim or preliminary results of studies,
if those results suggest possible adverse effects on man or the
environment.  This requirement continues as long as the products
are registered by the Agency.

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              II.  CHEMICAL COVERED BY THIS STANDARD
A.   Description of Chemical
     The following chemical is covered by this Registration
Standard:
     Common Name:  Chlorpropham
     Chemical Name:  Isopropyl N-(3-chlorophenyl)  carbamate
     CAS Number:  101-21-3
     Office of Pesticide Program Shaughnessy Number:  018301
     Empirical Formula:  CIQ^I 2C1NC-2
     Trade Names:  Beet-Kleen, Furloe, Sprout Nip, Spud-Nic,
                   Taterpex, Triherbicide-CIPC, Unicrop CIPC,
                   Chloro IPC, Bud Nip
     Year of Initial Registration:  1962
     Chemical Family:   Carbamate
     Description of Physical Characteristics of Chemical:
                Off white to light brown fused solid with  a
                melting point of 37 to 40 °C.
                Density - ca. 1.2 gram/milliliter (g/ml)
                pH - 6.5 to 7.5 and 0.6 to 0.7 g/ml
B.   Use Profile
     Type of Pesticide:  Herbicide and plant regulator.
     Pests  Controlled:   Suckers on tobacco plants, sprouting in
       stored potatoes, broadleaf weeds, and grasses.
     Registered Uses:   Terrestrial food and nonfood crop and
       ornamentals.
     Predominant Uses:   Alfalfa and ladino clover crops, berry
       crops, and ornamentals.
     Mode of Activity:   Chlorpropham suppresses transpiration and
       respiration as  well as inhibits root growth and epicotyl
       growth.
     Formulation Types  Registered:  98% TGAI;  5%, 10.3%, and 20%
       ai granule (G);  11.9% ai; 15% ai, 22.2% ai, 25% ai, 36%
       ai and 47% ai eraulsifiabie concentrate  (EC); 46% ai,

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  46.5% ai, 49.65% ai, 78.4% ai and 78.5% ai liquid ready to
  use (RTU).

Methods of Application:  Chlorpropham is a selective preplant
  incorporated, preemergence and postemergence herbicide and
  plant growth regulator.  Chlorpropham may be applied by
  ground or by air.

Application Rates:  Alfalfa 1-6 Ib ai/A; beans (lima and
  snap) 4 Ib ai/A; perennial grasses (seed crop)  no rate
  given; flowers (annual, biennial, perennial (bulbs)) 4-6
  Ib ai/A; garlic 2-4 Ib ai/A; spinach (fall seeded) 1-2 Ib
  ai/A; clovers 2-4 Ib ai/A; onions 4-8 Ib ai/A;  ornamentals
  4-8 Ib ai/A; safflower. 3-6 Ib ai/A; blackberries, raspberries
  6 Ib ai/A; blueberries 8-12 Ib ai/A; cranberries 10-20 Ib
  ai/A; southern peas 4-6 Ib ai/A; soybeans 2-4 Ib ai/A;
  sugar beets (seed crop) 3-4 Ib ai/A; tomatoes 4 Ib ai/A.

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 C.   Chemical Structure

                                                   COMMON NAME  OR
 STRUCTURE                CHEMICAL NAME             ABBREVIATION


 ~          0   CH,
            it   '                                         .        -
          H-C-O-CH  isopropyl 3-chlorocarbanilate   Chlorpropham
                CH,                                    or CIPC
      Cl
        N H»C~Q-r CM
               i     1-hydroxy-2-propyl 3-chloro-    laopropyl-OH-
                    carbanilate                        CIPC
    Cl
j_/  Chemical  structure for the herbicide chlorpropham.

2_/  Chemical  structure for the metabolite  1-hydroxy-2-propyl
~~   3-chlorocarbanilate.

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                     III.  AGENCY ASSESSMENT
A.   Summary
     No acceptable data are available for acute oral,  dermal,  or
inhalation toxicity; primary eye or dermal irritation;  or  dermal
sensitization studies.  These studies are required.

     No data are available for subchronic oral, dermal or  inhalation
toxicity or subchronic neurotoxicity studies.  Subchronic  dermal
(21-day) and subchronic oral toxicity studies in the rodent  and
non-rodent are required.

     Chronic toxicity studies in the rodent and non-rodent are
required.

     Acceptable data include rat and rabbit teratology'Studies.
The No Observed Effect Level (NOEL) in the rat for maternal
toxicity is 100 mg/kg/day and for developmental toxicity 350
mg/kg/day.  The rabbit teratology study showed the NOEL for
developmental toxicity to be 125 mg/kg/day and for maternal
toxicity 250 mg/kg/day.  Sufficient data are available on  the
reproductive toxicity of chlorpropham.  Chlorpropham caused
little toxicity and virtually no effect on reproduction in rats
administered chlorpropham in their diets at doses of 1000, 3,000
and 10,000 parts per million (ppm).

     A complete toxicological assessment is not possible until
the additional toxicology data required in Tables A and B of this
document are submitted.

     Available data are insufficient to fully assess the
environmental fate of chlorpropham.  The data requirement for a
hydrolysis study has been satisfied.  Photodegradation in water
and soil, aerobic and anaerobic soil metabolism, leaching and
absorption/desorption, volatility  (lab), field dissipation,
irrigated crops and fish accumulation studies must be submitted.
Additional rotational crop studies (confined and field) are also
required.

     The Agency is concerned about the potential for ground water
contamination by chlorpropham.  The Agency has determined that
additonal data are needed to characterize the  potential for
chlorpropham to enter ground water; therefore  chlorpropham  is the
subject of a ground water DCI notification.

     Available data are insufficient to fully  assess  the  ecological
effects of chlorpropham.  Avian studies, aquatic studies  and
residue monitoring studies must be submitted.

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 B.    Preliminary Risk Assessment

      Toxicology Characteristics

      The  acute toxicity, primary eye irritation, primary dermal
 irritation, and dermal sensitization data available are unacceptable.
 These studies are required.

      Subchronic Toxicity Studies

      No acceptable data are available on the subchronic oral
 toxicity of chlorpropham.  Studies are required in the rodent and
 the nonrodent.  If adequate chronic rodent and nonrodent studies
 are submitted, these subchronic studies will not be required.  No
 data  are available on the 21-day subchronic dermal, subchronic
 inhalation and subchronic neurotoxicity studies.  The 21-day
 subchronic dermal toxicity study is required.

      In a 21-day smoke inhalation study, standard samples of
 tobacco were spiked with chlorpropham and the metabolites 2-
 hydroxychlorpropham and 4-hydroxychlorpropham.  Mice were exposed
 to smoke from these samples of tobacco in a head-only method, at
 nominal concentrations of chlorpropham at 0, 60, 180, and 600
 ppm.   Dose-related increases in kidney and spleen weights were
 reported to have occurred at all dose levels.  Although this
 study  was considered acceptable, it failed to demonstrate a NOEL.

      If chlorpropham residues on tobacco greater than 0.1 ppm
 are detected, an additional smoke inhalation study will be required„

     Chronic Toxicity and Oncogenicity Studies

     There are currently no acceptable oncogenicity studies
 available with chlorpropham.  Studies are required in two species.

      In a supplementary rat study, 25 rats/sex/group were dosed
at 0,   10, 100, and 1000 mg/kg/day for two years.  A decreased body
weight over control values was accompanied by an increase in food
consumption in the highest dose group.  A depressed hematocrit
and hemoglobin concentration first appeared in data analyses
conducted on the 3 month bleedings and continued to the end  of
the study in the highest dose group.  The hemoglobin concentration
was approximately 93% (not reported to be statistically significant)
                                      8

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of controls in the 2,000 ppm dose group.  Organ/body weight
ratios were increased for the liver (146% and 126%), and  spleen
(785% and 382%) in the males and females, respectively, dosed at
the 20,000 ppm highest dose tested (HDT); but with only  1  and 3
animals surviving to terminal sacrifice in males and females,
respectively.  Since most animals died before terminal sacrifice,
and autolysis was frequent, the failure to find histopathology at
the highest dose level is meaningless.  Survival at the  2,000 ppm
raid dose tested (MDT) dose level was only five males and  16
females.

     This study is unacceptable because of inadequate numbers of
study animals, histology, and other reasons including test
compound identification.

    In a supplementary dog study, 2 dogs/sex/group were dosed at
the same dietary levels as rats and demonstrated simil'ar  toxicity,
and at the same dietary level.  Reduced body weight, increased
spleen/body weight ratio, and reduced hematocrit and hemoglobin
concentration occurred in males and females in the high dose
group.  The NOEL was 2,000 ppm or 40.8-54.8 mg/kg/day.  This
study is unacceptable because only 2 animals/sex/group were used,
histology was inadequately reported, and other deficiencies,
including test material identification were noted.

     There are currently no acceptable chronic studies available.
Chronic studies in the rodent and non-rodent are required.

     Teratology

     The data requirement for a teratology study in the rat  and
rabbit have been satisfied.

     A teratology study was conducted on 20 rats/group using
chlorpropham technical at 0, 100, 350, and 1000 mg/kg/day.
Maternal toxicity was noted at 350 and  1000 mg/kg/day in  the  form
of body weight decrements and increased spleen weights.   No  terata
occurred, but developmental toxicity occurred at  1000 mg/kg/day
in the form of increased incidence of rudimentary  14th rib.   The
NOEL for maternal toxicity is 100 mg/kg/day  (dose  level that
produces no observable effects in pregnant rats) ,  and for
developmental toxicity, 350 mg/kg/day.

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     A teratology study was conducted on 16 rabbits/group using
 chlorpropham  technical at 0, 125, 250, and 500 mg/kg/day.
 Maternal  toxicity was noted at 500 mg/kg/day in the form of
 reduced weight gain, anorexia, reduced fecal output, and blood-
 stained urine.  No statistically significant increase in terata
 occurred,  but developmental toxicity occurred at 250 and 500
 mg/kg/day  in  the form of postimplantation loss.  The NOEL for
 developmental toxicity is 125 mg/kg/day (dose level that produces
 no observable effects in the embryo or fetuses of rabbits), and
 for maternal  toxicity 250 mg/kg/day.

     Reproduction

     Sufficient data are available on the reproductive toxicity
 of chlorpropham.  Chlorpropham administered in the diet to rats
 (15 males  and 30 females per group) at doses of 1000, 3000, and
 10,000  ppra caused little toxicity and virtually no effect on
 reproduction.  Mating and fertility indexes in the FQ and Fj rats
 were not significantly reduced.  Similarly, gestation length,
 litter  size, and survival of FQ and F^ pups were not affected.
 Body weight gain was slowed in FQ and F-| adult rats dosed at 300Q
 and 10,000 pptn, but no effect was seen at the 1000 ppm dose level.
 Dose-related effects were seen on histological examination of FQ
 and Fj  adults, where brown pigment granules were seen in the
 reticuliendothelial cells of the liver, and the convoluted tubular
 epithelial cells of the kidney in the 3000 and 10,000 ppm dose
 level groups.  Hypercellularity of the bone marrow was also seen
 in these two dose groups.  Body weight and organ weight changes
 in the  Fj pups (lactation day 21) were not significant; ?2
male pups had significant reductions  in absolute and relative
 splenic weights.  In F-j adults, a severe increase in absolute
and relative spleen weights was seen  in males (10,000 ppm) and
 females (3000 and 10,000 ppm).

     Measurements of cholinesterase levels in the brain,  plasma,
and erythrocytes of Fj rats failed to demonstrate any significant
changes.

     Mutagenicity

     The available data are acceptable  for demonstrating  no
mutagenic effects in this test system.  The test system  was
the Mouse Lytnphoma (L5178y+/-) and chlorpropham  technical.   The
concentrations of the test material used ranged  from 13  to 75
ug/ml (resulting in 100 to 41% growth)  in  the  nonactivated system,
and 13  to 100 ug/ml (resulting in 52  to 80% growth)  in  the activated
system; thus both systems demonstrated  toxicity  and  were negative
 for mutagenicity.
                                       10

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     Studies are required on tests for other genotoxic effects
and structural chromosome aberrations.

     Metabolism

     There  is currently no acceptable animal metabolism study
with chlorpropham.  Limited data is available from the literature.

     Special studies may be necessary on a metabolite of chlorpropham
(p-methoxy-chlorpropham) found in potatoes and possibly in
animals.  This metabolite has been found at levels as high as
0.17 ppm in treated raw potatoes and 0.063 ppm in french fried
potatoes.   If p-methoxy-chlorpropham is not a metabolic product
produced by chlorpropham dosed rats, then mammalian tesfing may
be required for this metabolite.  However, if p-methoxy-chlorpropham
is a metabolic product produced by chlorpropham dosed rats (i.e,
the required metabolism studies) then the required toxicology
studies will adequately assess the potential hazards of p-methoxy-
chlorpropham.  The acute oral (rat), teratology (rat) , and
mutagenicity studies may be required to depict the toxicity of
this metabolite.

     In addition, if the plant and livestock metabolism and residue
studies reveal metabolites which are present at significant
levels, additional studies depicting their toxicity may also
be required.

C.   Other Science Findings

     Environmental Characteristics

     Available data are insufficient to fully assess the
environmental fate of chlorpropham.  The data requirement for a
hydrolyis study has been satisfied.

     A hydrolysis study showed that chlorpropham is relatively
stable in sterile water in the dark.  After 32 days in aqueous
buffered solutions at pH 4-, 7, and 9 held in the dark at 40°C,
about 90% of the applied chlorpropham remained undegraded.

     The remaining environmental fate studies are inadequate, but
supplementary data indicated that chlorpropham dissipates with a
half-life of <14 days in the upper 3 inches (parent compound) of
silty clay loam and silt loam soils regardless of site or
application procedure (incorpoated or suface-applied).

     Fish accumulation data indicated that chlorpropham bioaccumulated
in the skinless fillet of a bluegill sunfish to <100  times the
                                11

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 levels  in water.

      Supplementary data  indicate that chlorpropham accumulated in
 rotational crops planted  12 months after treatment.

      Reentry data are not required because available toxicological
 data  do not indicate a need for reentry data.

      The Agency is concerned about pesticide residues reaching
 ground water.  The potential for chlorpropham to reach ground
 water cannot be assessed  since no leaching data are available.
 Taking into consideration chlorpropham's high solubility and its
 relative stability in water and the mobility of a related chemical,
 propham, chlorpropham can be expected to leach and thus might
 enter ground water.

      Chlorpropham is the  subject of a ground water DC? notification
 and additional data are needed to fully characterize the potential
 for it to enter ground water.

      Ecological Characteristics

      Available data are  insufficient to fully assess the ecological
 effects of chlorpropham.

         Toxicity to Birds

     A supplementary study indicates that chlorpropham is
 practically nontoxic to waterfowl (mallard LDsn is greater than
 2000  mg/kg).

      Avian acute toxicity studies must be submitted.

         Toxicity to Fish and Aquatic Invertebrates

     A core study indicates that chlorpropham is moderately
 toxic to coldwater and warmwater freshwater fishes (bluegill
 sunfish LCso • 6.3-6.8 ppm; rainbow trout LCso » 3.02-5.7 ppm).

     Aquatic toxicity studies are required.

         Special Testing

     Residue monitoring studies will be required to  support  reliable
ecological risk assessments.
                                      12

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      Product Chemistry

     The Agency has evaluated the available data which identify
the composition, beginning materials and manufacturing process
and discuss the physical and chemical properties of chlorpropham.
The Agency has determined that these data must be resubmitted  for
each pesticide.  New requirements have been introduced, and
previously submitted data must be updated.

      Residue Chemistry

         Metabolism

           The metabolism of chlorpropham (CIPC) in growing
plants has been adequately described.  Additional data are required
regarding the metabolism of chlorpropham in stored potato tubers
treated postharvest and in livestock (ruminants and poultry).
Although the available data for dairy animals are inadequate,  the
following metabolites have been identified in milk:  isbpropyl
3-chloro-4-hydroxycarbanilate and 3-chloro-4-hydroxyacetanilide.
Although tolerances for chlorpropham and. its metabolite isopropyl-
OH-CIPC and interim tolerances for chlorpropham per sje have been
established, the tolerance definition will be reassessed on
receipt of the required metabolism data.

D.   Tolerance Reassessment

     Tolerances have been established for residues of chlorpropham
in a variety of RACs, in meat, fat, and meat byproducts (40 CFR
180.181; 40 CFR 180.319 interim tolerances).  EPA has evaluated the
residue and toxicology data supporting tolerances, and has addressed
the following regulatory issues:

     o  Whether the current tolerances and food additive  regulations
        are sufficient to cover the actual residues resulting
        from use (including uses registered under  FIFRA section
        24(c)  and intrastate uses).

     o  Whether group tolerances can be established in accordance
        with 40 CFR 180.34(f).

     o  Whether, in the absence of tolerances,  restrictions on
        use, grazing, or feeding of treated commodities are
        necessary.

     o  Whether the tolerances are expressed  accurately and in
        current terminology.
                                       13"

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      The regulatory determinations resulting from EPA's review
 are set  out  in  Section IV.A., Regulatory Positions and Rationales.

      Tolerances have been established for residues of chlorpropham
 and isopropyl-OH-CIPC at 50  ppm in or on potatoes and at 0.2 ppm
 in or on soybeans.

      Interim  tolerances have been established for residues of
 chlorpropham  per se in the following RACs:

                                          Parts Per Million
                 Commodities              	(ppm)	

          Hay of alfalfa, clover,                50
            and grass

          Alfalfa, clover, and                   20
            grass

          Beans (dry and succulent),              0.3
            blackberries, blueberries,
            cranberries, peas (dry and
            succulent), raspberries,
            spinach, and sugar beet tops

          Carrots, garlic, onions, rice           0.1
            grain, safflower seed,
            sugar beet roots, and
            tomatoes

          Eggs; milk; and the meat, fat,          0.05
            and meat byproducts of
            cattle, goats, hogs, horses,
            poultry, and sheep


      1.  Residue Data

         The  residue data reviewed in support of these  tolerances
include  che following:

         a.   Data on the nature of the residue in both  plants and
animals, including identification of major metabolites  and
degradates of chlorpropham.  The established tolerances are  based
on occurrence of chlorpropham (CIPC) and  its metabolite isopropyl-
OH-CIPC.  The interim tolerances are based on occurrence  of
chlorpropham per se.

         b.  Radiolabeled studies on the  uptake, translocation,
and metabolism of chlorpropham in plants  which show that  residues
                                     14

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appear  in Che shoots of soybeans, alfalfa, and cucumber.

         c.  Radiolabeled studies on Che metabolism and Cranslocacion
of chlorpropham in cows and chickens, which show that ruminants
and poultry fed preconditioning diets of unlabeled chlorpropham,
followed by [J^C]chlorpropham will accumulate 1^C-residues in
milk and eggs, in fat, muscle, kidney and liver tissues and will
eliminate '^C-activity primarily in urine and in the "excreta" of
chickens.

         d»  Analytical methodology for determining the levels of
residues of chlorpropham in plants and animals.  Adequate
spectrophotometric and gas-liquid chromatographic methods exist
for collection of data on combined residues of chlorpropham and
its metabolite  isopropyl-OH-CIPC from plant and animal commodities.

         e.   Storage stability data demonstrating that ^residues
of chlorpropham plus isopropyl-OH-CIPC are stable in or on frozen
plant commodities for up to 21 months.  No data are available for
animal  tissues or milk.

         f.   Data on the magnitude and levels of residues of
chlorpropham in individual RACs, animal products, and processed
food and feed items.  The metabolism of chlorpropham in growing
plants has been adequately described.  The conclusions regarding
the adequacy of data for all commodities are subject Co change
uncil Che plane mecabolism issues are successfully resolved.

     2.  Toxicology Data

         The Coxicology data considered in support of  the  tolerances
include a rat teratology study with the NOEL for maternal  toxicity
of 100 mg/kg/day and for developmental toxicity 350 mg/kg/day, a
rabbic  ceraCology study wich Che NOEL for macemal toxicity
250 mg/kg/day and 125 mg/kg/day for developmental coxicicy;  and  a
rac reproduccion study with a reproductive NOEL > 500 mg/kg/day
(HOT) and a systemic NOEL - 50 mg/kg/day  (LOT). "Refer to  the
toxicology section (Section III B, Preliminary Risk Assessment )
for detailed information on available data and additional  require-
ments.  Also refer to data tables for specific requirements.
                                        15

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     3.  Tolerances Issued

         Tolerances are established for chlorpropham (CIPC)  and
its metabolite 1-hydroxy-2-propyl-3'-chlorocarbanilate (calculated
as CIPC) in or on potatoes and soybeans.   Interim  tolerances are
established for CIPC in or on the following RACs:   Hay of alfalfa,
clover, and grass; alfalfa, clover, and grass;  beans (dry and
succulent), blackberries,  blueberries,  cranberries,  peas  (dry and
succulent), raspberries, spinach, sugar beet tops,  carrots,
garlic, onions, rice grain, safflower seed, sugar  beet roots,
tomatoes, eggs, milk, and  the meat, fat,  and meat  byproducts of
cattle, goats, hogs, horses, poultry, and sheep.

Canadian tolerances have been established for residues
of chlorpropham in or on potatoes, snap beans,  soybeans,  and
cranberries.
                                                       *

         No Mexican tolerances or Codex Maximum Residue Limits
(MRLs)  have been established for chlorpropham.
                                        16

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              IV.  REGULATORY POSITION AND RATIONALE

A.   Regulatory Positions and Rationales

       1.  The Agency is not initiating a Special Review of
chlorpropham at this time.

          Rationale;  Since available data are limited, the Agencv
is not yet able to make a determination as to whether any of the
criteria specified in 40 CFR 154.7 have been met or exceeded.

       2.  The Agency is requiring submission of environmental
fate data. .
                                                       *
          Rationale;  Such data -is required by 40 CFR 158.130.  In
addition the Agency is concerned about the potential contamination
of ground water.  The Agency believes that chlorpropham has this
potential based on such factors as chemical structure, solubility,
and use patterns.  These concerns cannot be adequately addressed
until  sufficient data are submitted and evaluated.

       3.  The Agency will not approve any significant new food
uses*  of chlorpropham until additional residue chemistry data are
available to assess existing uses.

          Rationale;  It is Agency policy not to establish
significant new uses where major data gaps exist.  When additional
data are evaluated, the Agency will determine whether significant
new food uses may be established.

       4.  The Agency is requiring registrants to submit residue
monitoring studies.

          Rationale;  These studies will be required to quantitate
the residue levels resulting from terrestrial non-food, and aquatic
food crop uses of chlorpropham.  These field studies will be valuable
in supporting theoretical hazard assessments made from laboratory
acute  and chronic studies'.

       5.  The Agency is requiring supporting data for  the established
tolerance for residues of chlorpropham and isopropyl-OH-CIPC  in
or on  potatoes.
* Significant new use is defined in 44 FR 27934, May 11, 1979.
In the case of a new food or feed use, the Agency will consider
as significant an increase in Theoretical Maximum Residue Contribution
of greater than 1 percent.


                                17

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           Rationale!  The available data are insufficient to
 assess  the established tolerance.

      6.  The Agency is requiring that registrants propose an
 appropriate permanent tolerance for chlorpropham residues of
 concern in or on carrots, sugar beet roots, sugar beet tops, garlic,
 onions,  spinach, beans, tomatoes, blackberries, blueberries,
 cranberries, raspberries, alfalfa forage, alfalfa hay, grass
 forage,  grass hay, clover forage, clover hay and safflower.

          Rationale;  On submission and acceptance of all required
 data and/or tolerance proposals, the interim tolerances will be
 revoked  concomitant with the establishment of permanent tolerances
 for chlorpropham residues in or on these commodities by amendment
 to 40 CFR 180.181.

      7.  Additional supporting data for a group tolerance
 must be  submitted if the registrant seeks a crop group tolerance.

          Rationale!  The available data are insufficient to
 determine if a group tolerance is appropriate for bulb vegetables ,
 root and tuber vegetables, leafy vegetables (except Brassica),
 legume vegetables, fruiting vegetables (except cucurbits), small
 fruits  and berries, nongrass animal feeds  (forage, fodder, straw
 and hay).

      8.  The Agency is requiring additional data depicting the
 potential for concentration of chlorpropham residues of concern
 (a) in meal, hulls, soapstock, crude oil,  refined oil, and  the
 resulting "grain" dust processed from soybean seeds bearing
 measurable, weathered residues;  (b) in potato granules, potato
 chips, and potato peels (wet and dried) processed from raw  tubers
 bearing measurable weathered residues; (c)  in safflower meal
 and oil processed from safflower seed bearing measurable weathered
 residues; (d) in dried pulp, molasses, and  refined sugar processed
 from sugar beet roots bearing measurable weathered residues; and
 (e) in dry pomace, puree, catsup, and juice processed  from  tomatoes
bearing measurable weathered residues.

          Rationale;  Support for these positions are  respectively
as follows: (a) The data submitted from processing studies  do
not depict processed commodity samples derived  from soybean seed
bearing measurable weathered residues and  no data were submitted
depicting residues in "grain" dust from soybeans,   (b)   The
analysis of potato peels was not matched with corresponding
analysis of whole tubers to determine the  degree of concentration
of residues,  (c) No processing study was  submitted,   (d)   The
studies  failed to analyze molasses and refined  sugar,  and  did
                                        18

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not: use roots bearing measurable weathered residues,  (e)   No
data pertaining to the potential for residue concentration in
processed products of tomatoes were submitted.

      9.  A tolerance must be proposed and supporting data
submitted for birdsfoot trefoil forage and birdsfoot  trefoil hay.

          Rationale;  The registrant must either propose  appropriate
tolerances or remove this commodity from the pertinent product
labels.

     10.  The Agency will revoke interim tolerances for residues
of chlorpropham per jse_ in or on rice grain and peas (dry  and
succulent).

          Rationale;  Currently no registered uses exist  for
these commodities.                                    -

     11.  The Agency has identified certain data that will
receive immediate review when submitted.

          Rationale;  Certain data are essential to the Agency's
assessment of this pesticide and its uses and/or may trigger
the need for further studies which should be initiated as soon
as possible.  The following studies have been identified to
receive priority review as soon as they are received by the Agency:

   §158.125  Residue Chemistry

             171-4  Nature of the Residue of Plants
             171-4  Nature of the Residue of Animals

   §158.130  Environmental Fate

             161-2  Photodegradation (in water)
             161-3  Photodegradation (on soil)
             162-1  Aerobic Soil Metabolism
             162-2  Anaerobic Soil Metabolism
             163-1  Leaching and Adsorption/Desorption
             163-2  Volatility (lab)
             164-1  Dissipation (soil)
             165-1  Rotational Crops (confined)
             165-3  Irrigated Crops
             165-4  Accumulation (in fish)
                                    19-

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    §158.135  Toxicology

          81-1  Acute oral toxicicy (rat)
          81-2  Acute dermal toxicity (rabbit)
          81-3  Acute inhalation (rat)
          81-4  Primary eye irritation
          81-5  Primary dermal irritation
          81-6  Dermal sensitization
          82-2  21 day dermal (rabbit)
          83-1  Chronic toxicity (rodent and non-rodent)
          83-2  Oncogenicity (rat and mouse)
          84-2  Chromosomal aberration
                Other mechanisms of mutagenicity
          85-1  General metabolism


    §158.145  Wildlife and Aquatic Organisms

          70-1  Residue monitoring protocol and studies
          71-1  Avian acute oral
          71-2  Avian subacute dietary
          72-1  Acute freshwater fish
          72-2  Acute invertebrate acute
          72-3  Acute estuarine and marine organism
          72-4  Fish early life stage/aquatic invertebrate
                life cycle
          72-5  Fish life cycle

    §158.150  Plant Protection

          122-1  Seedling germination/seedling emergence
          122-1  Vegetative Vigor
          122-2  Aquatic plant growth

     12.  While data gaps are being filled, currently registered
MPs and EPs containing chlorpropham as the sole active ingredient
may be sold, distributed, formulated and used, subject to the
terms and conditions specified in this Standard.  Registrants
must provide or agree to develop additional data, as specified in
the Data Appendices, in order to maintain existing registrations.

          Rationale;  Under FIFRA, the Agency does not normally
cancel or withhold registration simply because data are missing
or are inadequate (see FIFRA sections 3(c)(2)(B) and 3(c)(7)).

          Issuance of this Standard provides a mechanism  for
identifying data needs.  These data will be reviewed and  evaluated,
after which the Agency will determine if additional regulatory
changes are necessary.
                                    20

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 B.   Criteria for Registration

      To be registered  or reregistered under  this Standard, products
 must contain chlorpropham as  the  sole active  ingredient, bear
 required labeling,  and conform  to the product  composition, acute
 toxicity limits,  and use pattern  requirements  listed  in this
 section.

 C.   Acceptable Ranges and Limits

      1 .  Product  Composition  Standard

          To be registered or  reregistered  under  this  Standard, MPs
 must contain chlorpropham as  the  sole active  ingredient.   Each MP
 formulation proposed for registration must be fully described
 with an appropriate certification of limits,  stating  maximum and
•minimum amounts of the active ingredient and  inert  ingredients
 which are present in products,  as well  as  impurities  found at
 greater than 0.1  percent.

      2.  Acute Toxicity Limits

          The Agency will consider registration of  technical grade
 and  MPs containing  chlorpropham provided that the  product  labeling
 bears appropriate precautionary statements for the  acute  toxicity
 category in which each product  is placed.

      3.  Use Patterns

          To be registered under this Standard, MPs  may be labeled
 for  formulation into EPs only for the commodities  listed  in
 Appendix III, EPA Compendium  of Acceptable Uses--Chlorpropham.
 The  EPA Compendium of  Acceptable Uses lists  all  acceptable uses,
 as well as approved maximum application rates and  frequencies.

 D.    Labeling

      All MPs (and EPs, if covered by this  Standard)  must bear
 appropriate labeling as specified in 40 CFR 162.10.   Appendix
 II contains information on label requirements.

      No pesticide product containing chlorpropham may be  released
 for  shipment by the registrant after January  1989, unless the
 product bears an  amended label which complies with the requirements
 of this Standard.
                                       21

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     No pesticide product containing chlorpropham may be distributed,
sold, offered for sale, held for sale, shipped,  delivered for
shipment, or received and (having been so received)  delivered  or
offered to be delivered by any person after January  1990 unless
the product bears an amended label which complies with the
requirements of this Standard.

     In addition to the above, the following information must
appear on the labeling:

     1.  Ingredients Statement

         The ingredient statement for MPs must list  the active
ingredient as:

         Isopropyl N-(3-chlorophenyl)carbamate ....   %
                                                      «
     2.  Use Pattern Statements

         All MPs must state that they are intended for formulation
into EPs for acceptable use patterns.  Labeling must specify
sites, which are listed in Use Patterns, Section C.3.  However,
no use may be included on the label where the registrant fails to
agree to comply with the data requirements in Table A for that
use pattern.

     3.  Precautionary Statements

         Statements for Manufacturing Use Products

              Do not discharge effluent containing this
              product into lakes, streams, ponds,
              estuaries, oceans, or public waters unless
              this product is specifically identified
              and addressed in an NPDES permit.  Do not
              discharge effluent containing this product
              to sewer systems without previously
              notifying the sewage treatment plant
              authority.  For guidance, contact your
              State Water Board or Regional Office of
              the EPA.

         Statement for End-Use Products

              Terrestrial Food and Nonfood Crop

              Do not apply directly  to water or wetlands
              (swamps, bogs, marshes, potholes).  Do
                                  22

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not apply where runoff is  likely to  occur,
Do not contaminate water by cleaning of
equipment or disposal of wastes.
                     23

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            V.  PRODUCTS SUBJECT TO THIS STANDARD

     All produces containing one or more of the pesticides
 identified  in Section II.A. are subject to certain requirements
 for data submission or changes in composition, labeling or
 packaging of the product.  The applicable requirements depend
 on whether.the product is a manufacturing or end use product
 and whether the pesticide is the sole active ingredient or
 one of multiple active ingredients.

    Products are subject to this Registration Standard as
 follows:

 A.  Manufacturing use products containing this pesticide as
 the sole active ingredient are subject to:

     1.  The restrictions (if any) upon use, composition, or
     packaging listed-in Section IV, if they pertain to the
     manufacturing use product.

     2.  The data requirements listed in Tables A and B?

     3.  The labeling requirements specified for manufacturing
     use products in Section IV.

     4.  Administrative requirements (application forms, Confiden-
     tial Statement of Formula, data compensation provisions)
     associated with reregistration.
2 Data requirements are listed in the three Tables in
Appendix I of this Registration Standard.  The Guide to
Tables in that Appendix explains how to read the Tables.

  Table A lists generic data requirements applicable to all
products containing the pesticide subject to this Registra-
tion Standard.  Table B lists product-specific data applicable
to manufacturing use products.  The data in Tables A and  B
need not be submitted by a producer who is eligible for the
fonnulator's exemption for that active ingredient.

  Table C lists product-specific data applicable to end use
products.  The Agency has decided that, in most cases,  it
will not require the submission of product-specific data  for
end use products at this time.  Therefore most Registration
Standards do not contain a Table C.


                                     24

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 B.   Manufacturing use products containing this pesticide
 as  one  of multiple active ingredients are subject to:

     1.   The  data requirements listed in Table A.

     2.   The  labeling requirements specified for manufacturing
     use products in Section IV.

 C.   End use  products containing this pesticide as the
 sole active  ingredient are subject to:

      1.   The restrictions (if any) upon use, composition, or
      packaging  listed in Section IV if they pertain to the
      end  use product.

      2.   If  eligible for the formulator's exemption^, the
      data requirements listed in Table C.
                                                      *
      3.   If  not eligible for the formulator's exemption, the
     _data requirements listed in Table A and the data require^
      ments listed in Table C.

      4.   The labeling requirements specified for end use
      products in Section IV.

 D.   End use  products containing this pesticide as one of
 multiple  active ingredients are subject to:

      1.   If  not eligible for the formulator's exemption,
      the  date requirements listed in Tables A and C.
3 If you purchase from another producer and use as the
source of your active ingredient only EPA-registered products,
you are eligible for the formulator's exemption for generic
data concerning that active  ingredient (Table A) and product-
specific data for the registered manufacturing use product
you purchase (Table B).

     Two circumstances nullify this  exemption:

     1)  If you change sources of active  ingredient to  an
unregistered product, formulate your own  active ingredient,
or acquire your active ingredient from a  firm with ownership
in common with yours, you  individually lose the exemption
and become subject to the  data requirements in Table A.

     2)  If no producer subject to  the generic data requirements
in Table A agrees to submit  the required  data, all end  use
producers lose the exemption, and become  subject  to those
data requirements.


                                     25

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      2.   If eligible for the forraulator's exemption,  the ,
      data requirements listed in Table C.

      3.   The labeling requirements specified for end  use
      products in Section IV.


       VI.  REQUIREMENT FOR SUBMISSION OF GENERIC DATA
                                                •
      This portion of the Registration Standard is a notice
 issued under the authority of FIFRA sec. 3(c)(2)(B).   It
 refers to the data listed in Table A, which are required to
 be submitted by registrants to maintain in effect the regis-
 tration of products containing this active ingredient.^

 A.  What  are generic data?

      Generic data pertain to the properties or effects'of a
 particular active ingredient.  Such data are relevant to an
 evaluation of all products containing that active ingredient
 regardless of whether the product contains other ingredients
 (unless the product bears labeling that would make the data
 requirement inapplicable).

      Generic data may also be data on a "typical formulation"
 of a  product.  "Typical formulation" testing is often required
 for ecological effects studies and applies to all products
 having that formulation type.  These are classed as generic
 data, and are contained in Table A.

 B.  Who must submit generic data?

      All  current registrants are responsible for submitting
 generic data in response to a data request under FIFRA sec.
 3(c)(2)(B) (DCI Notice).  EPA has decided, however, not  to
 require a registrant who qualifies for the formulator's
 exemption (FIFRA sec. 3(c)(2)(D) and § 152.85) to submit
generic data in response to a DCI notice if the  registrant
who supplies the active ingredient in his product is  complying
with  the data request.

      If you are granted a generic data exemption, you rely  on
 the efforts of other persons to provide  the Agency with  the
 required data.  If the registrants who have committed to
generate and submit the required data fail to take appropriate
 steps to meet the requirements or are no longer  in compliance
with  this data requirements notice,  the  Agency will consider
4 Registrations granted after  issuance  of  this  Standard  will
be conditioned upon submission or  citation of the data listed
in this Registration Standard.


                                    26

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 chat both  they and you are not in compliance and will normally
 initiate proceedings to suspend the registrations of both
 your product(s) and their product(s) unless you commit to submit
 and  submit  the required data in the specified timeframe.   In
 such cases,  the Agency generally will not grant a time extension
 for  submitting the data.

      If you  are not now eligible for a formulator's exemption,
 you  may qualify for one if you change your source of supply
 to a registered source that does not share ownership in
 common with  your firm.  If you choose to change sources of
 supply, the  Confidential Statement of Formula must identify
 the  new source(s) and you must submit a Formulator's Exemption
 Statement  form.

      If you  apply for a new registration for products containing
 this  active  ingredient after the issuance of this Registration
 Standard, you will be required to submit or cite generic
 data  relevant to the uses of your product if, at the time
 the  application is submitted, the_data have been submitted
 to the Agency by current registrants.  If the required data
 have  not yet been submitted, any new registration will be
 conditioned upon the new registrant's submission or citation
 of the required data not later than the date upon which
 current registrants of similar products are required to provide
 such  data.   See FIFRA sec. 3(c)(7)(A).  If you thereafter fail
 to comply with the condition of that registration to provide
 data, the registration may be cancelled (FIFRA sec. 6(e)>.

 C.  What generic data must be submitted?

      You may determine which generic data you must submit by
 consulting Table A.  That table lists the generic data needed
 to evaluate current uses of all products containing this
 active ingredient, the uses for which such data are required,
 and  the dates by which the data must be submitted to the
Agency.

 D.  How to comply with PCI requirements.

     Within 90 days of your receipt of this Registration
 Standard, you must submit to EPA a completed copy of the  form
entitled "FIFRA Section 3(c)(2)(B) Summary Sheet"  (EPA Form
8580-1, enclosed) for each of your products.  On that  form
you must state which of the following six methods you will
use to comply with the DCI requirements:

      1.  You will submit the data yourself.

     2.  You have entered into an agreement with one or more
registrants to jointly develop (or share  in the cost of~
developing) the data, but will not be submitting the data
yourself.   If you use this method, you must state who  will
submit the data on which you will rely.   You must  also  provide


                                      27

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 EPA with documentary  evidence  chat an agreement has been
 formed which  allows you to rely upon the data to be submitted.
 Such evidence may be:  (1) your letter offering to join in
 an  agreement  and the  other registrant's acceptance of your
 offer,  (2)  a  written  statement by the parties that an agreement
 exists,  or  (3)  a written statement by the person who will be
 submitting  the  data that you may rely upon its submission.
 The Agency  will also  require adequate assurance that the
 person whom you state will provide the data is taking appropriate
 steps  to secure it.   The agreement to produce the data need
 not specify all of the terms of the final arrangement between
 the parties or  a mechanism to resolve the terms.

      If  you and other registrants together are generating or
 submitting  requested  data as a task force or consortium, a
 representative  of the group should request a Joint Data
 Submitter Number from the Registration Support and Emergency
 Response Branch, Registration  Division.  The request must
 include  the following information:

     a.   A  list of the members of the consortium;
     b.   The  name and address of the designated representative
          of the consortium, with whom EPA will correspond
          concerning the data;
     c.   Identity of  the Registration Standard containing
          the  data requirement;
     d.   A  list of the products affected (from all members
          of the consortium); and
     e.   Identification of the specific data that the con-
          sortium will be generating or submitting.

     The  Agency will  assign a number to the consortium, which
should be used on all data submissions by the consortium.

     3.   You  have attempted to enter into an agreement  to
jointly develop data, but no other registrant Has accepted
 rour offer.   You request that EPA not suspend your registration
 or non-compliance with the PCI.EPA has determined that,
as  a general  policy,  it will not suspend the registration of
a product when  the registrant has in good faith sought  and
continues to  seek Co  enter into a data development/cost
sharing program, but  the other registrants developing the
data have refused to  accept its offer.  [If your  offer  is
accepted, you may qualify for Option 2 above by entering
into an agreement to  supply the data.]

     In order to qualify for this method, you must:

     1.   File with EPA a completed "Certification of Attempt
to  Enter  into an Agreement with other Registrants for Develop-
ment of Data" (EPA Form 8580-6, enclosed).
                                  28

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      2.   Provide us with a copy of your offer to the other
 registrant  and proof of the other registrant's receipt of your
 offer (such as a certified mail receipt).  Your offer must,
 at  a  minimum, contain the following language or its equivalent:

      [Your  company name] offers to share in the burden of
      producing the data required pursuant to FIFRA\sec.
      3(c)(2)(B) in the [name of active ingredient]  Registration
      Standard upon terms to be agreed or failing agreement
      to be  bound by binding arbitration as provided by FIFRA
      section 3(c)(2)(B)(lii).

 The remainder of your offer may not in any way attempt to
 limit  this  commitment.  If the other registrant to whom your
 offer  is made does not accept your offer, and if the other
 registrant  informs us on a DCI Summary Sheet that he will
 develop and submit the data required under the DCI, then you
 may qualify for this option.  In order for you to avoid
 suspension  under this method, you may not later withdraw or
 limit  your  offer to share in the burden of developing the
 data.

      In addition, the other registrant must fulfill its
 commitment  to develop and submit the data as required by this
 Notice in a timely manner.  If the other registrant fails to
 develop the data or for some other reason would be subject to
 suspension, your registration as well as that of the other
 registrant will normally be subject to initiation of suspension
 proceedings, unless you commit to submit and submit the required
 data  in the specified timeframe.  In such cases, the Agency
 generally will not grant a time extension for submitting the data.

     4.  You request a waiver of the data requirement.  If
 you believe that a data requirement does not (or should not)
 apply to your product or its uses, you must provide EPA with
 a statement of the reasons why you believe this is so.  Your
 statement must address the specific composition or use factors
 that lead you to believe that a requirement does not apply.
 Since the Agency has carefully considered the composition and
uses of pesticide products in determining that a data  require-
ment applies, EPA does not anticipate that many waivers will
be granted.  A request for waiver does not extend  the  time-
 frames for developing required data, and if your waiver
request is denied, your registration may be suspended  if you
 fail to submit the data.

     5.  You request that EPA amend your registration  by deleting
 the uses for which the data are needed.You are not required
 to submit data for uses which are no longer on your  label.

     6.  You request voluntary cancellation of the registration
of your product(s) for which the data are needed.


                              1      29

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 E.   Testing Protocols. Standards for Conducting Acceptable
     Testa. Guidance on Evaluating and Reporting Data.

     All  studies  required under this Notice must be conducted
 in  accordance with test standards outlined in the Pesticide
 Assessment Guidelines, unless other protocol or standards are
 approved  for use by the Agency in writing.

     As noted herein, these EPA Guidelines, which are referenced
 in  the Data Tables, are available from the National Technical
 Information Service (NTIS), Attn: Order Desk, 5285 Port Royal
 Road, Springfield, VA  22161 (tel: 703-487-4650).

     Protocols approved by the Organization for Economic
 Cooperation and  Development (OECD) are also acceptable if
 the  OECD-recommended test standards conform to those specified
 in  the Pesticide Data Requirements regulation (Part 158.70).
 Please note, however, that certain OECD standards (such as
 test duration, selection of test species, and degradate
 identification which are environmental fate requirements) are
 less restrictive than those in the EPA Assessment Guidelines
 listed above.  When using the OECD protocols, they should be
 be modified as appropriate so that the data generated by the
 study will satisfy the requirements of Part 158.  Normally,
 the Agency will not extend deadlines for complying with data
 requirements when the studies were not conducted in accord
 with acceptable standards.  The OECD protocols are available
 from OECD, 1750 Pennsylvania Avenue, N.W., Washington, D.C.
 20006.

 F.   Procedures for requesting a change in testing protocol.

     If you will generate the required data and plan to use
 test procedures which deviate from EPA's Pesticide Assessment
 Guidelines or the Reports of Expert Groups to the Chemicals
 Group, Organization for Economic Cooperation and Development
 (OECD) Chemicals Testing Programme, you must submit  for EPA
 approval  the protocols you propose to use.

     You should submit your protocols before beginning testing,
because the Agency will not ordinarily accept as sufficient
 studies uaing unapproved protocols.  A request  for protocol
 approval will not extend the timeframe for submission of  the
data, nor will extensions generally be given to  conduct
 studies due to submittal of inappropriate protocols.


G.  Procedures for requesting extensions of  time.

     If you think that you will need more time  to  generate
 the data than is allowed by EPA's schedule,  you may  submit a
 request for an extension of time.  Any request  for a time
                                      30

-------
 extension which is made as an initial response to a section
 3(c)(2)(B) request notice must be submitted in writing to
 the  Product Manager listed at the end of this section and
 must be made by the 90-day deadline for response.  Once
 dates have been committed to and EPA has accepted these
 commitments, any subsequent requests for a time extension
 must be submitted in writing to the Office of Compliance
 Monitoring at the address given in Section IX.E.

     EPA will view failure to request an extension before
 the data submission response deadline as a waiver of any
 future claim that there was insufficient time to submit the
 data.  While EPA considers your request, you must strive to
 meet the deadline for submitting the data.

     The extension request should state the reasons why you
 believe that an extension is necessary and the steps you
 have taken to meet the testing deadline.  Time extensions
 normally will not be granted due to problems with laboratory
 capacity or adequacy of funding, since the Agency believes
 that with proper planning these can be overcome.

     A request for an extension does not extend the timeframe
 for submission of the data.  If EPA denies your request for
 £i time extension and you do not submit the data as requested,
 EPA may begin proceedings to suspend the registrations of
 your products.

 H.  PR Notice 86-5 and Any Other Requirements Referenced or
    Included Within this Notice.

    All data submitted in response to this Notice must comply
 with EPA requirements regarding the reporting of data,
 including the manner of reporting, the completeness of results,
 and the adequacy of any required supporting  (or raw) data,
 including, but not limited to, requirements  referenced or
 included in this Notice or contained in PR Notice 86-5 (issued
 July 29, 1986).

 I.  Existing stocks provision upon suspension or cancellation.

     The Agency has determined that if a registration  is
 suspended for failure to respond to a DCI  request under
 FIFRA sec. 3(c)(2)(B), an existing stocks  provision  is not
 consistent with the Act.  Accordingly, the Agency does not
 anticipate granting permission to sell or  distribute  existing
 stocks of suspended product except  in rare circumstances.
 If you believe that your product will be suspended or cancelled
and that an existing stocks provision should be granted,  you
have the burden of clearly demonstrating to  EPA that  granting
                                     31

-------
 such permission would be consistent with the Act.  The following
 information must be  included  in any request for an existing
 stocks  provision:

      1.   Explanation of why an existing stocks provision is
      necessary, including a statement of the quantity of
      existing  stocks and your estimate of the time required
      for  their sale or distribution; and
                                              •
      2.   Demonstration that such a provision would be consis-
      tent with the provisions of FIFRA.


   VII. REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA

      Under its DCI authority, EPA has determined that certain
 product-specific data are required to maintain your registrations
 in effect.  Product-specific data are derived from testing
 using a specific formulated product, and, unlike generic
 data, generally support only  the registration of that product.
 All  such data must be submitted by the dates specified in
 this  Registration Standard.

      If you have a manufacturing use product, these data are
 listed in Table B.  If you have an end use product, the data
 are  listed in Table C.  As noted earlier, the Agency has
 decided that it will not routinely require product-specific
 data  for end use products at  this time.  Therefore, Table C
 may not be contained in this Registration Standard; if there
 is no Table C, you are not required to submit the data at
 this  time.

      In order  to comply with  the product specific data require-
 ments, you must follow the same procedures as for generic data.
 See Section VI.D, E, F, and G.  You should note,.however, that
 product chemistry data are required for every product, and  the
 only acceptable responses are options VI.D.1. (submit data)
 or VI.D.6.(cancellation of registration).

     Failure to comply with the product-specific data require-
ments for your products will  result in suspension of the
 product's registration.
                                      32

-------
    VIII.  REQUIREMENT FOR SUBMISSION OF REVISED LABELING

     FIFRA requires each product to be labeled  with  accurate,
complete and sufficient instructions and precautions,  reflecting
the Agency's assessment of the data supporting  the product
and its uses.  General labeling requirements are set out  in
40 CFR 162.10 (see Appendix II - LABELING and SUMMARY).   In
addition, labeling requirements specific to products containing
this pesticide are specified in Section IV.D of this Registra-
tion Standard.  Applications submitted in response to this
notice must include draft labeling for Agency review.

     If you fail to submit revised labeling as  required,
which complies with 40 CFR 162.10 and the specific instructions
in Section IV.D., EPA may seek to cancel or suspend  the
registration of your product under FIFRA sec. 6.


               IX.  INSTRUCTIONS FOR SUBMISSION

A.  Manufacturing Use Products (MUPs) containing the subject
    pesticide as sole active ingredientl

    1_.  Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division
for each product subject to this Registration Standard:

        a.  The "FIFRA Section 3(c)(2)(B) Summary Sheet" (EPA
    Form 8580-1), with appropriate attachments.5

        b.  Confidential Statement of Formula  (EPA Form 8570-4).

        c.  Formulator's Exemption Statement (EPA Form 8570-27),
    if applicable.

        d.  Evidence of compliance with data compensation
    requirements of FIFRA sec. 3(c)(1)(D).  Refer to 40 CFR
    152.80-152.99.
5 If on the Summary Sheet, you commit to develop  the data,
present arguments that a data requirement  is not  applicable
or should be waived, or submit protocols or modified protocols
for Agency review, you must submit a copy  of the  Summary
Sheet (and any supporting information)  to  the Office of
Compliance Monitoring, which will be monitoring the data
generated in response to this notice.   This submission  is  in
addition to responding to the Product Manager, and should  be
submitted to the Office of Compliance Monitoring  at the
address given at the end of this  section.   (Actual studies
are not to be submitted to the Office of Compliance Monitoring.)


                                    33

-------
     2.   Within 9 months from receipt of this document you
 must submit  to the Product Manager:

         a.   Application for Pesticide Registration (EPA
     Form 8570-1).

         b.   Two copies of any required product-specific data
     (See Table B).

         c.   Three copies of draft labeling, including the
     container label and any associated supplemental labeling.
     Labeling should be either typewritten text on 8-1/2 x 11
     inch paper or a mockup of the labeling suitable for
     storage  in 8-1/2 x 11  files.  The draft label must 'indicate
     the  intended colors of the final label, clear indication
     of the front panel of the label, and the intended type
     sizes of the text.

         d.   Product Specific Data Report (EPA Form 8580-4).

      3.  Within the times set forth in Table A. you must
submit to the Registration Division all generic data, unless
you  are  eligible for the formulator's exemption.  If for any
reason any test is delayed or aborted so that the schedule
cannot be met, immediately notify the Product Manager and
the  Office of Compliance Monitoring of the problem, the
reasons  for  the problem, and your proposed course of action.

B.   Manufacturing Use Products containing the subject pesticide
     in combination with other active ingredients.

     1.   Within 90 days from receipt of this document, you
must submit  to the Product Manager in the Registration Division:

         a.   FIFRA sec. 3(c)(2)(B) Summary Sheet, with appropriate
     attachments^ (EPA Form 8580-1).

         b.  Confidential Statement of Formula (EPA Form 8570-4)

        c.  Formulator's Exemption Statement (EPA Form 8570-27),
     if applicable.

     2.  Within 9 months of receipt of this document, you must
submit to the Product Manager:

        Three copies of draft labeling, including the container
     label and any associated supplemental labeling.  Labeling
     should be either typewritten text on 8-1/2  x  11  inch
    paper or a mockup of the labeling suitable  for storage
     in 8-1/2 x 11  files.  The draft label must  indicate  the
     intended colors of the final label, clear  indication of
     the  front panel of the label, and the  intended type
    sizes of the text.


                                      34

-------
     3.  Within the time frames set forth in Table A.  you must
 submit  to  che Registration Division all generic data,  unless
 you  are eligible for the forraulator1s exemption.  If  for any
 reason  any test is delayed or aborted so that the schedule
 cannot  be  met, immediately notify the Product Manager and
 the  Office of Compliance Monitoring of the problem,  the
 reasons for the problem, and your proposed course of  action.

 C.   End Use Products containing the subject pesticide as sole
     active ingredient.

     1.  Within 90 days from receipt of this document,  you
 must submit to the Product Manager in the Registration Division:

        a.  FIFRA Section 3(c)(2)(B) Summary Sheet,  with
     appropriate attachments* (EPA Form 8580-1).

        b.  Confidential Statement .of Formula (EPA Form 8570-4).

        c.  Formulator's Exemption Statement (EPA Form 8570-27),
     if  applicable.

     2.  Within 9 months from receipt of this document you
must submit to the Product Manager:

        a.  Two copies of any product-specific data,  if required
    by  Table C.

        b.  Product Specific Data Report (EPA Form 8580-4),
     if  Table C lists required product-specific data.

        c.  Three copies of draft labeling, including the
    container label and any associated supplemental labeling.
     Labeling should be either typewritten text on 8-1/2 x 11
     inch paper or a mockup of the labeling suitable for
    storage in 8-1/2 x 11 files.  The draft labeling must
     indicate the intended colors of the final label, clear
     indication of the front panel of the label, and the
     intended type sizes of the text.  End use product labeling
    must comply specifically with the instructions in Section IV
     (Regulatory Position and Rationale).

D.   End Use Products containing the subject active ingredient
    as  one of multiple active ingredients'

    Within 9 months from the receipt of this document,  you
must submit to the Product Manager:

        Three copies of draft labeling, including the  container
    label  and any associated supplemental labeling.  Labeling
    should be either typewritten text on 8-1/2  x  11  inch
    paper  or a mockup of the labeling suitable  for storage
    in  8-1/2 x 11 files.  The draft labeling must indicate
    the intended colors of the final label,  clear indication


                                    35

-------
    of Che front panel of the label, and the intended type
    sizes of the text.  End use product labeling must comply
    specifically with the instructions in Section IV (Regulatory
    Position and Rationale).

E.  Intrastate Products containing the subject pesticide either
    as sole active ingredient or in combination with other
    active ingredients.

    These products are being called in for full Federal regis-
tration.   Producers of these products are being sent a letter
instructing them how to submit an application for registration.

F.  Addresses

     The required information must be submitted to the following
address:

     Robert J. Taylor, PM 25
     Registration Division (TS-767C)
     Office of Pesticide Programs
     Environmental Protection Agency
     401  M St., SW
     Washington, D.C.  20460

     The address for submissions to the Office of Compliance
Monitoring is:

     Laboratory Data Integrity Assurance Division
     Office of Compliance Monitoring  (EN-342)
     Environmental Protection Agency
     401  M St., SW
     Washington, D.C. 20460.
                                    36

-------
       APPENDIX  I



      DATA TABLES
- 36-A -

-------
                           TGUIDE-1

                       GUIDE TO TABLES

     Tables A, B, and C contain listings of data requirements
 for  the pesticides covered by this Registration Standard.

     Table A contains generic data requirements that apply to
     the pesticide in all products, including data requirements
     for which a "typical formulation" is the test substance.

     Table B contains product-specific data requirements that
     apply only to a manufacturing use product.

     Table C contains product-specific data requirements that
     apply only to an end use product.

     The data tables are generally organized according to  the
 following format:
                                                     *
 1.   Data Requirement (Column 1).  The data requirements are
 listed in the order in which they appear in 40 CFR Part 158.
 The  reference.numbers accompanying each test refer to the
 test protocols set out in the Pesticide Assessment Guidelines,
 which are available from the National Technical Information
 Service, 5285 Port Royal Road, Springfield, VA  22161.

 2.   Test Substance (Column 2).  This column lists the composition
 of the test substance required to be used for the test, as
 follows:

     TGAI = Technical grade of the active ingredient
     PAI »  Pure active ingredient
     PAIRA » Pure active ingredient, radio labeled
     TEP «  Typical end use formulation
     MP -   Manufacturing use product
     EP -   End use product

Any other test substances, such as metabolites, will be
 specifically named in Column 2 or in footnotes to the table.

 3.  Use pattern (Column 3).  This column indicates the use
patterns Co which the data requirement applies.  Use patterns
are the same as those given in 40 CFR Part 158.  The following
 letter designations are used for the given use patterns:

     A - Terrestrial, food
     B - Terrestrial, non-food
     C » Aquatic, food
     D " Aquatic, non-food
     E - Greenhouse, food
     F • Greenhouse, non-food
     G - Forestry
     H - Domestic outdoor
     -I » Indoor

Any other designations will be  defined  in  a footnote to the table,

                                  37

-------
                            TGUIDE-2

 4.  Does EPA have data?  (Column 4).  This column indicates one
 of three answers:

      YES - EPA has data  in  its files that satisfy this data
      requirement.   These  data may be cited by other registrants
      in accordance with data compensation requirements of
      Part 152,  Subpart E.

      PARTIALLY -  EPA  has  some data in its files, but such data
      do not  fully  satisfy the data requirement.  In some cases,
      the Agency may possess data on one of two required species,
      or may  possess data  on one test substance but not all.
      The term may  also indicate that the data available to
      EPA are incomplete.  In this case, when the data are
      clarified, or  additional details of the testing submitted
      by the original  data submitter, the data may be determined
      to be acceptable.  If  this is the case, a footnote to
      the  table  will usually say so.

      NO -  EPA either  possesses no data which are sufficient
      to fulfill the data  requirement, or the data which EPA
      does  possess are flawed scientifically in a manner that
      cannot be  remedied by clarification or additional infor-
     mation.

5.  Bibliographic citation  (Column 5).   If the Agency has
acceptable data in  its tiles, this column lists the identifying
number  of  each  study.   This normally is the Master Record
Identification  (MRID)  number, but may be a GS number if no
MR{D  number has been  assigned.  Refer to the Bibliography
Appendices for  a complete citation of the study.

6.  Must additional data be submitted? (Column 6).  This
column  indicates whether  the data must be submitted to the
Agency.   If column  3  indicates that the Agency already has
data, this column will usually indicate NO.  If column 3
indicates  that  the  Agency has only partial data or no data,
this column will usually  indicate YES.  In some cases, even
though  the Agency does not have the data, EPA will not require
its submission because of the unique characteristics of the
chemical; because data on another chemical can be used to
fulfill the data requirement; or because the data requirement
has been waived or  reserved.  Any such unusual situations
will be explained in  a footnote to the table.

7.  Timeframe for submission (Column 7).  If column 5 requires
that data be submitted, this column indicates when the data
are to  be submitted,  based on the issuance date of the Regis-
tration Standard.   The timeframes are those established either
as a  result of  a previous Data Call-In letter, or standardized
timeframes established by PR Notice 85-5 (August 22,  1985).

8.  Footnotes (at the end of each table).  Self-explanatory.

                                  38

-------
                                                            TABLF. A



                                          GENERIC DATA REQUIREMENTS FDR CHLORPROFriAM
\G
Test
Data Requirement Substance
SI 58. 120 Product Chemistry
Product Identity and Composition
61-2 - Description of Beginning
Materials and Manufac-
turing Process TGAI
61-3 - Discussion of Formation
of Impurities TGAI
Analysis and Certification of
Product Ingredients
62-1 - Preliminary Analysis
of Product Samples TGAI
Physical and Chemical Characteristics
Does EPA Have Data
To Satisfy Require- Tiroeframe
ment? (Yes, No or Bibliographic Must Additional for
Partially) Citation fj Data Be Submitted? Submission^
No N/A Yes2/ 6 Months
No N/A YesV 6 Months
No N/A YesV 12 Months
63-2  - Color                     TGAI



63-3  - Physical State            TGAI



63-4  - Odor                      TGAI



63-5  - Melting Point             TGAI



63-6  - Boiling Point             TGAI
No



No



No



No



No
N/A



N/A



N/A



N/A



N/A
                                                                                              Yesfy



                                                                                              Yesfy
                                                                                                 ^/ , 8/
6 Months



6 Months



6 Months



6 Months



6 Months

-------
                                                         TABLE A



                                       GENERIC DATA REQUIREMENTS FDR CHLORPROPHAM

Test
Data Requirement Substance
Does EPA Have Data
To Satisfy Require-
ment? (Yes, No or Bibliographic
Partially) Citation */
Must Additional
Data Be Submitted?
Timeframe
for
Submission^/
$1 58. 120 Product Chemistry (continued)
63-7
63-8
63-9
-63-10
63-11
363-12
63-13
- Density, Bulk Density,
or Specific Gravity TGAI
- Solubility TGAI or PAI
- Vapor Pressure TGAI or PAI
- Dissociation Constant TGAI or PAI
- Octanol/Water Partition
Coefficient PAI
- pH TGAI
- Stability TGAI
No
No
No
No
No
No
No
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Yesfy
Yesfy
Yesfy
Yesfy
Yesfy ,9
Yesfy , JO/
Yesfy
6 Months
6 Months
6 Months
6 Months
6 Months
6 Months
6 Months
Other Requirements;



64-1  - Submittal of Samples
N/A
N/A
N/A
N/A

-------
                                                       TABLE A

                                      GENERIC DATA REQUIREMENTS FOR CKLDRPROFHAM
SI58.120 Product Chemistry Footnotes

\j  Data must be submitted within the Indicated timeframes, which begin on the date of the Guidance Document (see front
    cover for this date).

21  Not applicable.  Although product chemistry data may have been submitted in the past,  the Agency has determined
    that these data must be resubmitted for each pesticide.  New requirements have been introduced and previously
    submitted data must be updated.  Therefore, bibliographic citations for the old data are not applicable.

3/  Complete information must be provided regarding the nature of the process (batch or continuous), the relative
    amounts of the beginning materials and the order in which they are added, the chemical equations for each intended
    reaction, equipment used to produce each intermediate and final product, reaction conditions, the duration of
    each step of the process, purification procedures, and quality control measures.  In addition, the name and
    address of the manufacturer, producer, or supplier of each beginning material must be provided, along with
    information regarding the properties of each beginning material used to manufacture each product.

4/  A detailed discussion of all impurities that are or may be present at J> 0.1%, based on knowledge of the beginning
    materials, chemical reactions (intended and side) in the manufacturing process, and any contanination during and
    after production must be submitted.

5/  Five or more representative samples must be analyzed for the amount of active ingredient and each impurity for
    which a certified limit is required.  Complete validation data (accuracy, precision) must be submitted for each
    analytical method used.

6/  Physicochemical characteristics (color, physical state, odor, melting point,  boiling point,  specific gravity,
    solubility, vapor pressure, dissociation constant, KW pH» an^ stability)  as required in 40 CFR 158.120 and more
    fully described in*the Pesticide Assessment Guidelines, Subdivision D must be submitted.

l_l  Data needed if the technical chemical is a solid at roan temperature.

8/  Data needed if the technical chemical is a liquid at room temperature.

9/  Required if the technical chemical is organic and nonpolar.

10/ Required if the test substance is dispersible with water.

-------
                                                      TABLE A

                                     CENTO 1C DATA REQUIREMENTS FOR CHLORPROPHAM
      Data Requirement
  Test
Substance
Does EPA Have Data
To Satisfy Require-
ment?  (Yes, No or
Partially)
                                      Timefraroe
   Bibliographic  Must Additional        for
   Citation       Data Be Submitted?  Submission1/
SI58.125 Residue Chemistry

171-2 - Chemical Identity^/

171-3 - Directions for Use

171-4 - Nature of Residue
          (Metabolism)

      - Plants
    PAIRA
               (See product labels)
    Partially
      - Livestock
    PAIRA
    Partially
00035475
00035485
00035489
00035496
00035498
00036377
00036395
00036629
00036632
00036638
00036640
00037860
00037866
00114715
00139860
40378102
,00035480
,00035488
,00035490
,00035497
,00035505
,00036394
,00036628
,00036630
,00036635
,00036639
.00036644
,00037861
,00037881
,00114794
,40378101
00114700, 00114701,
00114739.
                                                             Yes/
                                                         6 Months

                                                          6 Months
YesV
18 Months
                YesV
               18 Months

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                                                       TABLE A

                                      GENERIC DATA REQUIREMENTS FOR CHLDRPROPHAri
      Data Requirement
  Test
Substance
Does EPA Have Data
To Satisfy Require-
ment?  (Yes, No or
Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted?
Timeframe
   for
Submission^ /
SI58.125 Residue Chemistry (continued)

171-4 - Residue Analytical
          Method
        - Plant Residues
        - Animal Residues
 TOM and
Metabolites
171-4 - Storage Stability
          Data
 PAI or TEP
Metabolites
    Partially     00035896,00036385.
                  00036626.00036636,
                  00036637.00036641,
                  00037032,00037033.
                  00037034.00037037,
                  00037046,00037863,
                  00039946,00045294,
                  00045295,00051807,
                  00051812,00051814.
                  00051822.00051824,
                  00051834,00051838,
                  00051845.00051856,
                  00051861,00083334,
                  00106293,00114710,
                  00114715,00114717,
                  00114718,00114739.
                  00114740,00114741,
                  00114743,00114751,
                  00114785,00114794,
                  00115388,05016141,
    Partially     00037031.00054672
                   Reserved7/
                                    15 Months
                     Yes£/9/
                   Reserved"'0/
                     18 Months

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                                                       TABLE A

                                      GENERIC DATA REQUIREMENTS FDR CHLORPROPHAM
      Data Requirement
  Test
Substance
Itoes EPA Have Data
To Satisfy Require-
ment?  (Yes, No or
Partially)
                                      Timeframe
   Bibliographic  Hist Additional        for
   Citation       Data Re Submitted?  Submission1/
§158.125 Residue Chemistry (continued)

171-4 - Magnitude of the
          Residue - Crop
          Field Trials

        - Root and Tuber
            Vegetable Group
          o Carrots

          o Potatoes
          o Sugar Beet Roots
          Leaves of Root and
            Tuber Vegetables
            Group

          o Sugar Beet Tops

          Bulb Vegetables
            Group

          o Garlic
    TEP

    TEP
    TEP
    TEP
    TEP
    Partially

    Partially
    Partially
    Partially
00114725,00115388

00083155,00114695
00114718,00114741,
00114747,00114750,
00114777,00114785,
00114795,

00051824,00114725,
00114794,00115388.
00051824,00114794,
00115388.
    Partially     00051834,00114725.
YesJJy

Yes12/,39/
Yes1*/
Yes16/
18 Months

18 Months
24 Months
18 Months
24 Months
                                                                            18 Months
                                                                            18 Months

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                                                         TABLE A

                                        GENERIC DATA REQUIREMENTS FOR CHLGRPROFriAM
        Data Requirement
                      Test
                    Substance
Does EPA Have Data
To Satisfy Require-
ment?  (Yes, No or
Partially)
                                   Timeframe
Bibliographic  Must Additional        for
Citation       Data Be Submitted?  Submission1/
  SI58.125 Residue Chemistry (continued)

  171-4 - Magnitude of the
            Residue - Crop Field
            Trials (cont'd)

            o Ghions                TEP
            Leafy Vegetables
              Group

            o Spinach               TEP
LH
Legume Vegetables
  Group

o Beans (Succulent
    and Dried)          TEP
            o Soybeans              TEP
                                           Partially
                                           Partially
    Partially


    Partially
                  00083158.00114725.
                  00115388.
                  00114710,00114715,
                  00114794.
                                                                     00051812,00051822,
                                                                     00114715.00115388.
                                                         00030995
                                                         00036642
                                                         00037037
                                                         00037042
                                                         00037045
                                                         00051817
                                                         00114715
                                                         00114778
     .00036382.
     ,00037035,
     ,0*0037038.
     .00037043,
     .00051815.
     .00106293.
     .00114717,
Yes18/,39/
                     Yes'*/
                                      Months
               18 Months
                     Yes20/        18 Months
                                   18 Months
Yes22/,39/    24 Months

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                                             TABLE A

                            GENERIC DATA REQUIREMENTS FOR CHLORPROPHAM
Test
Data Requirement Substance
SI 58. 125 Residue Chemistry (continued)
171-4 - Magnitude of the
Residue - Crop Field
Trials (cont'd)
- Fruiting Vegetables .
Group
o Tomatoes TEP
- Shall Fruits and
Berries Group
o Blackberries TEP
^
* o Blueberries TEP
o Cranberries TEP
Does EPA Have Data
To Satisfy Require- Tiroeframe
ment? (Yes, No or Bibliographic Must Additional for
Partially) Citation Data Be Submitted? Submission^


Partially 00114710,00114725, Yes23/
00051838. Yes^V

Partially 00051807 Yes££/
Partially 00114710 Yes£fy
Partially 00051 86 1 , 001 1 471 5 , Yes£7/


18 Months
24 Months

18 Months
18 Months
18 Months
                                                         00114725,00114737,
                                                         00114748.
o Raspberries
TEP
Partially     00114710
Yes28/
18 Months

-------
                                                       TABLE A

                                      GENERIC DATA REQUIREMENTS FDR CHLORPROPHAM
      Data Requirement
  Test
Substance
Does EPA Have Data
To Satisfy Require-
ment?  (Yes, No or
Partially)
                                       Timefrane
   Bibliographic  Must Additional         for
   Citation       Data Be Submitted?   Submission1/
SI58.125 Residue Chemistry (continued)

171-4 - Magnitude of the
          Residue - Crop Field
          Trials (cont'd)

        - Grass Forage, Fodder;
            and Hay Group
          o Grass Forage
              and Hay
          Nopgrass  Animal
            Feeds Group

          o Alfalfa Forage
              and Hay
          o Birdsfoot Trefoil
              Forage and Hay

          o Clover Forage
              and Hay
    TEP
    TEP
    TEP
    TEP
    Partially
    Partially
       No


    Partially
00114715,00114794,
00114737.
00051851,00051852,
00051853,00051854,
00051855,00114710,
00114725,00114737,
00114794.
00036390,00036392,
00037285,00058143,
00058147,00114725,
00114737.
Yes29/
18 Months
18 Months
Yes3!/._3?_/     18 Months
                        Yes32/
Yes33/
               18 Months
18 Months

-------
                                                       TABLE A

                                      GENERIC DATA REQUIREMENTS FOR CHLORPROPHAM
      Data Requirement
                                   Test
                                 Substance
Does EPA Have Data
To Satisfy Require-
ment?  (Yes, No or
Partially)
                                   Timeframe
Bibliographic  Must Additional        for
Citation       Data Be Submitted?  Submission1/
00
SI58.125 Residue Chemistry (continued)

171-4 - Magnitude of the
          Residue - Crop Field
          Trials (cont'd)

        - Miscellaneous
            Commodities

          o Safflower Seed        TEP
        - Tobacco

171-4 - Magnitude of the Residue
          in Meat/Milk/Poultry/Eggs

        - Fat,  Meat, and Meat
          Byproducts of Poultry,
          Cattle, Goats, Hogs,
          Horses, and Sheep,
          Eggs, and Milk

171-4 - Magnitude of the Residue
          in Drinking and Irrigation
          Water

171-4 - Nature and Magnitude
          of the Residue in
          Fish and Shellfish
                                                         Partially
                                                           Yes
                                                           No
                  00114710,00114715
                  00114725.

                  00094865.00094866
                  00094867
                     Yes34/,39/
18 Months
24 Months
                     No
                                                        Partially     00037029,00054669     Reserved^/
                                          Yes37/
                                    15 Months
                                                        Partially     00035995,00035998     Reserved3^/

-------
                                                       TABLE A

                                      GENERIC DATA REQUIREMENTS FOR CHIDRPROPHAM
5158.125 Residue Chanistry Footnotes

\J  Data must be submitted within the indicated tlraeframes, which begin on  the date of  the Guidance Document (see
    front cover for this date).

2J  Refer to Product Chemistry Data Requirement tables.

y  Refer to footnotes 14, 21, and 23 for details of required  product  label amendments.

4/  Data must be submitted depicting the uptake,  distribution, and metabolism of  ring-labeled  [^Cjchlorpropham £n
    stored potatoes following postharvest application at a rate sufficiently high to permit complete ^-residue
    characterization.   Representative samples from the required metabolism studies must also be analyzed using accepted
    enforcement methods to ascertain that these methods  will determine all possible metabolites of  concern including
    any bound/ conjugated residues of concern.

V  Metabolism studies must be submitted utilizing ruminants and poultry.  Animals must be dosed  for a minimum of 3
    days with ring-labeled [I^Cjchlorpropham at a level  sufficient to  make identification  and quantification of
    residues possible.  Milk and eggs must be collected  for analysis twice daily  during the dosing  period,  and
    animals must be sacrificed within 24 hours  after administration of the final  dose.  The distribution and identity
    of residues must be determined in milk, liver, kidney, muscle, and fat of ruminants, and in eggs, liver, kidney,
    muscle, and fat of poultry.   Samples from the requested animal metabolism studies must also be  analyzed using
    current enforcement methods  to determine the  usefulness of these methods for  analysis  of animal commodities.
    The enforcement method must  be capable of determining all  free and bound/conjugated residues of concern.

6/  Chlorpropham per se must be  subjected to Multiresidue Protocols II, III, and  IV and isopropyl-OH-CIPC must be
    subjected to analysis by Multiresidue Protocols I-IV available from National  Technical Information Service
    under order No. PB 203734/AS.   The registrant must select  the specific method(s) recommended for tolerance
    enforcement.  The method must include a hydrolysis step at the tissue stage to release bound/conjugated residues.
    Spiking may not produce conjugates.   Therefore, enforcement methods must be tested in  conjunction
    with plant and animal metabolism studies.   The efficiency  of extraction of bound/conjugated residues of concern
    must be determined for any or all residue data collection  methods  the registrant has used or will use  to support
    tolerances.   Residues must be "weathered" and not  simply spiked into samples  prior to  analysis.  This may best
    be conducted in conjunction  with plant and  animal  metabolism studies involving radiolabeled material.   This is
    required because conjugates  are expected to occur  with both soluble and insoluble plant constituents.   Such a

-------
                                                       TABLE A

                                      GENERIC DATA REQUIREMENTS  FOR CHLDRPHOPHAM
SI58.125 Residue Chemistry Footnotes (cont'd)

    hydrolysis step must be incorporated into all methods  to be used  for data collection in support of tolerances.
    The method(s) selected for 3-chloroaniline analysis must be validated by  submission of data relating to specificity,
    sensitivity, precision, and accuracy;  one approach may be to  spike  radiolabeled 3-chloroaniline prior to extraction
    and hydrolysis if one of the existing methods for chlorpropham analysis is used.

]_/  If the requested data regarding the nature of the residues in plants and  animals reveal the occurrence of additional
    metabolites of concern, additional  analytical methods  for data collection and  enforcement  is reserved pending
    results.

8/  Hie storage intervals and conditions of samples used to  support all established tolerances for residues of
    chlorpropham must be submitted.   These data must be accompanied by  data depicting the percent decline in residues
    of chlorpropham for all plant samples stored  frozen for  periods longer than  21  months.   Data for animal tissues
    and milk are also needed.  On receipt of these data, the adequacy of the  aforementioned tolerances will be
    reevaluated.  In laboratory tests using fortified samples, the pure active ingredient and  pure metabolite must
    be used.  However, if field-weathered samples are used,  the test  substance must be a typical end-use product.

9/  All residue data requested in this  Standard must be accompanied by  data regarding storage  length and conditions
    of sample storage.  The data must also be submitted depicting the stability  of residues of chlorpropham (including
    3-chloroaniline) under the conditions  and for the time intervals  specified,  if different than those discussed in
    footnote 8.  In laboratory tests using fortified samples,  the pure  active ingredient and pure metabolites must be
    used.  However, if field-weathered  samples are used, the test substance must be a typical  end-use product.

107 If the requested metabolism data indicate the presence of additional residues  of toxicological concern in plant
    and animal commodities, data depicting stability of such residues in storage will be required.

11/ Data depicting chlorpropham residues of concern in or  on mature carrots harvested ca. 65 days following a single
    preanergence application of the 20% G or 4 Ib/gal EC formulation  at 6 Ib  ai/A.   Tests must be conducted in TX
    (19%), WA (17%), and either MI (19%) or WI (17%); numbers  in  parentheses  are percentages of carrot production
    outside of CA.  Such data is necessary for establishment of a permanent tolerance for chlorpropham residues of
    concern in or on carrots.

-------
                                                       TABLE A

                                      GENERIC DATA REQUIR01EOTS FOR CHLDRPROPHAM
SI58.125 Residue Chemistry Footnotes (cont'd)


12/ Data depicting chlorpropham residues of concern (including 3-chloroaniline)  in potatoes analyzed immediately after
    treatment in commercial storage with, in separate tests,  an RTU formulation  at 0.033 Ib ai/1000 Ib of potatoes
    applied as an aerosol through forced air circulation systems,  and an EC formulation at 0.027 Ib ai/1000 Ib of
    potatoes applied as a dilute aqueous spray to potatoes moved along a conveyer belt.   Samples from each test must
    be taken from several positions in the storage pile.

1_3/ A processing study depicting chlorpropharo  residues of concern  (including 3-chloroaniline)
    in potato granules, potato chips,  and potato peels (wet and dried)  processed from raw tubers bearing measurable,
    weathered residues.  If residues concentrate in any of these processed  commodities,  the registrants must propose
    appropriate food/feed additive tolerances.

14/ Data depicting chlorpropharo residues of concern in or on  sugar beet roots harvested  following post emergence
    application of the 4 Ib/gal EC formulation at 4 Ib ai/A by ground equipment  and metered into irrigation water in
    separate tests.  Tests must be conducted in the State of  CA, the only State  in which these uses are registered.
    The registrants must propose a PHI that is  consistent with accepted cultural practices and the current use direc-
    tions and limitations and is reflected by  the requested data.   The registrants must  also propose an appropriate
    permanent tolerance for chlorpropharo residues of concern  in or on sugar beet roots.

15/ A processing study depicting chlorpropham  residues of concern  in dried  pulp, molasses, and refined sugar processed
    from sugar beet roots bearing measurable, weathered residues of chlorpropham.   If residues are shown to concentrate
    in any of these commodities, the registrants must propose appropriate food or feed additive tolerances.

16/ Data depicting chlorpropham residues of concern in or on  sugar beet tops harvested following postemergence
    application of the 4 Ib/gal EC formulation at 4 Ib ai/A  by ground  equipment and  metered into irrigation water.
    in separate tests.   Tests must be conducted in the State  of CA,  the only State in which these uses are registered.
    The registrants must propose a PHI that is  consistent with accepted cultural practices and the current use direc-
    tions and limitations.   The registrants must also propose an appropriate permanent tolerance for chlorpropham
    residues of concern in or on sugar beet tops.                             *

17/ The registrants must propose an appropriate permanent tolerance for chlorpropham  residues  of concern in or on
    garlic.

-------
                                                           TABLE A

                                          GENERIC DATA REQUIREMENTS FOR CHLORPROPHAM
    5158.125 Residue Chemistry Footnotes (cont'd)

    18/ Data depicting residues of chlorpropham (including 3-chloraniline)  in or on onions (including green onions)
        harvested 30 days after the postemergence application of 8 Ib ai/A.   The 4 Ih/gal EC and 20% C formulations
        must both be represented in the data submitted.   Tests must be conducted in the States of CA (27%), CO (13%).
        Ml (4%)/TX (4%). OR (18%) and MI (8%) or NY (9%)  representing ca. 90% of U.S.  bulb onion production.  Tests
        must be conducted in the states of CA (40%) and TX (49%) in the case.of green onions.  Such data is necessary
        for establishment of a permanent tolerance for chlorpropham residues of concern in or on onions.

    19/ Data must be submitted depicting chlorprophan residues of concern  in or on spinach harvested 30 days after
        postemergence application of the 4 Ib/gal EC formulation at 2 Ib ai/A at the six- to eight-leaf growth stage.
        Tests must be conducted in the States of AR, MD,  OK,  and VA where special local needs registrations are in
        effect.  Such data is necessary for establishment of  a permanent tolerance for chlorpropham residues of concern
        in or on spinach.

    20/ Data must be submitted depicting chlorpropham residues of concern  in or on succulent and dried beans harvested
        at maturity following a preemergence application  with the 4 Ib/gal  EC formulation at 4 and 6 Ib ai/A, respectively.
        Tests with succulent beans must be conducted in NY (13%), OR (18%),  and WI (35%), and tests with dried beans
        must be conducted in CA (16%), CO (13%) or NE (12%),  and MI (24%) or ND (14%).   Such data is necessary for
        establishment of a permanent tolerance for chlorpropham residues in or on beans (dry and succulent).

<~n  21/ Since bean vines and bean hay are raw agricultural commodities, the registrant must propose tolerances for
^      chlorpropham residues in or on bean vines and hay and submit appropriate supporting residue data.
        Alternatively, the registrants may propose amendments to the pertinent product labels that restrict feeding
        or grazing of treated bean vines and bean vine hay by livestock.

    22/ Data must be submitted depicting the potential for concentration of chlorpropham residues of concern (including
        3-chloroaniline) in meal, hulls, soapstock, crude oil, refined oil,  and the resulting grain "dust" processed
        from soybean seeds bearing measurable, weathered  residues.   If the  data indicate a potential for concentration
        of residues in any of these processed products, appropriate food/feed additive tolerances must be proposed.
                                                                                   t
    23/ Data must be submitted depicting chlorpropham residues of concern in or on tomatoes harvested at regular
        intervals after application according to the following treatment regimes with the 4 Ib/gal EC formulation:
        (i) a single preplant broadcast application in FL at  4 Ib ai/A; and (ii)  a single preplant treatment followed

-------
                                                       TABLE A

                                      GENERIC DATA REQUIREMENTS FOR CHtORPROPHAM
SI58.125 Residue Chemistry Footnotes (cont'd)

    by a single postemergence directed spray each at 4 Ib ai/A in CA.   Such data is necessary for establishment of
    a permanent tolerance for chlorpropham residues in or on tomatoes  and propose an appropriate PHI.

24/ Data must be submitted depicting chlorpropham residues of concern  in dry pomace, puree,  catsup, and juice
    processed from tomatoes bearing measurable weathered residues.   It may be necessary to use exaggerated rates
    to obtain measurable residues in or on the raw agricultural commodity.  If residues concentrate in any of
    these processed products, appropriate food/feed additive tolerances must be proposed.

25/ The registrant must propose an appropriate permanent tolerance for chlorpropham residues in or on blackberries.

26/ Data must be submitted depicting chlorpropham residues of concern  in or on blueberries following fall and spring
    application of the 20% G or 4 Ib/gal EC formulations at 12 Ib ai/A/application.  Tests must be conducted in NJ
    (34%), MI (41%), and OR (3%)/WA (6%) representing ca.  80 percent of U.S. blueberry acreage.   Such data is
    necessary for establishment of a permanent tolerance for chlorpropham residues in or on  blueberries.

27/ The registrants must propose a permanent tolerance of 0.3 ppm for  chlorpropham residues  in or on cranberries.

28/ Data must be submitted depicting chlorpropham residues of concern  in or on raspberries following early spring
    application of the 20% G or 4 Ib/gal EC formulations at 6 Ib ai/A.   Tests must be conducted in OR (38%)/WA (44%),
    and MI (3%) representing ca. 90 percent of U.S.  raspberry acreage.   Such data is necessary for establishment of
    a permanent tolerance for chlorpropham residues  in or on raspberries.

29/ The registrants must amend the federally-registered 4 Ib/gal EC label and specify a dosage rate for this use.
    Appropriate supporting residue data must be submitted.  Such data  is necessary for establishment of a permanent
    tolerances for chlorpropham residues of concern in or on grass  forage and grass hay.

30/ Data must be submitted depicting chlorpropham residues in or on Bermuda grass, bluegrass,  and bromegrass or
    fescue (as hay mixed with alfalfa)  harvested 40 days following  a single pqstemergence  broadcast soil application
    of the 4 Ib/gal EC formulation at 3 Ib ai/A.   Tests must be conducted in KY.   Alternatively,  the registrant may
    elect to cancel this use permitted under EPA SLN No. KY-780006.

31/ Data must be submitted depicting chlorpropham residues (including  3-chloroaniline)  in  or on  alfalfa and  alfalfa
    hay harvested 20 days following postemergence application of (in separate tests)  the 20% G and 4 Ib/gal  EC

-------
                                                         TABLE A

                                        GENERIC  DATA REQUIREMENTS FDR CHLORPROPHAM
   SI58.125 Residue Chantstry Footnotes  (cont'd)

       fotraulations at 6 Ib ai/A.   Ground application of the EC formulation must be made in 20 gal water/A and aerial
       applications must be made in 5 gal/A.  Tests must be conducted in CA (8%) or OR  (2%),  IA  (7%)  or IL (4%),
       KS (5%)  or NE (6%) or SD (2%), and MI  (6%) or MN (7%) or WI  (12%) which collectively produced  ca.  60 percent of
       the total U.S.  alfalfa crop in 1985 and represent the major  U.S. alfalfa production  regions.   Such data is
       necessary for establishment of a  permanent tolerances for chlorpropham residues  of concern in  or on alfalfa
       forage and alfalfa hay.

   32/ The registrants must propose permanent tolerances for chlorpropham residues in or on birdsfoot trefoil
       forage and birdsfoot trefoil hay, and  submit appropriate supporting residue data.  The 4  Ib/gal EC is to be
       applied  postemergence at 4  Ib ai/A in  MI  (46%) or WI (40%).  Numbers in parentheses  represent  percentages  of birds-
       foot trefoil acreage.   Residues must be determined in or on  forage and field-dried hay.

   337 Data must be submitted depicting  chlorpropham residues in or on clover hay harvested 40 days following
       a single postemergence application of  the 20% G and 4 Ib/gal EC formulations (in separate tests) at 4 Ib ai/A.
       Tests must be conducted in  CA which produced virtually all of the 1982 ladino clover  crop, MN  which produced 36
       percent  of the 1982 U.S. sweet clover  crop and 10 percent of the U.S. red clover crop,  and OR  which produced 24
       percent  of 1982 red clover, 95 percent of U.S. crimson clover, and 84 percent of 1982  U.S. white clover.
Ln     The registrants must propose appropriate tolerances for chlorpropham residues of concern  in or on  clover forage
•t*     and clover hay.

   34/ Data must be submitted depicting  chlorpropham residues of concern (including 3-chloroaniline)  in or on  samples of
       safflower seed harvested at normal crop maturity following preplant incorporated application of the 4 Ib/gal EC
       formulation at 6 Ib ai/A.   Tests must  be conducted in the States of CA (57%) and NV  (30%)  representing  ca. 90
       percent  of the 1982 U.S.  safflower acreage.  Such data is necessary for establishment  of a permanent
       tolerance for chlorpropham  residues in or on safflower seed.

   35/ A processing study must  be  submitted depicting chlorpropham  residues (including  3-chloroaniline) in safflower
       meal and oil processed from safflower  seed bearing measurable, weathered residues.   If  concentration of residues
       occurs in either of these commodities  during processing, the registrants must propose appropriate  food/feed
       additive tolerances.

   36/ Presently, the nature of the residue in animals is not adequatly understood.  Upon receipt of  the  data  requested

-------
                                                         TABLE A

                                        GENERIC DATA. REQUIREMENTS FOR CKLORFROFriAM
   SI58.125 Residue Chemistry Footnotes (cont'd)

       in  the section "Nature of the Residue in Animals," the need for, and the nature of tolerances for chlorprophan)
       residues in livestock will be assessed.

   37/  Data must be submitted depicting the nature and magnitude of chlorprophan residues in potable water
       following the registered treatment of cranberries.  Degradation products in water must be identified
       and quantified.  Should detectable residues of concern occur in water then the registrants must propose an
       Acceptable Residue Level in Drinking Water (ARLDW) and a tolerance for residues from irrigation water in all
       crops, or propose label amendments restricting the exposure to drinking or irrigation water.

   38/  The nature and magnitude of residues of chlorprophan in water resulting from aquatic use have not been identified,
       If detectable residues of concern are found in water (refer to footnote 37), then additional residue data for
       fish may be required.

   39/  A metabolite/degradate of chlorpropham, 3-chloroaniline, is a probable mutagen.  This compound was found to be a
       plant residue in a published metabolism study (James and Prendeville.  1969.  J.  Agric. Food Chan. 17(6):1257).
       To ascertain the magnitude of its presence in plant commodities and their processed products, residue data are
       required for the following representative commodities and any processed products:  alfalfa, potatoes, onions,
       safflower seed, and soybeans.  If 3-chloroaniline is detected in any of these RACs or their processed products,
       residue data on 3-chloroaniline will be required for all registered crops and their processed products.  Note
       that the method must specifically determine 3-chloroaniline present in the sample prior to any hydrolysis step
       associated with the analytical method used.  Refer to footnotes 9, 12, 13, 18, 22, 31, 34 and 35 (above) for
       specific deficiencies regarding 3-chloroaniline.
Ui

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                 TABLE A




GENERIC DATA REQUIREMENTS FOR CHLORPROPHAM
Test
Data Requirement Substance
$158
.135 Toxicology

Use
Patterns

Does EPA Have Data
To Satisfy This Timeframe
Requirement? (Yes. Bibliographic Must Additional for Sub-
No or Partially) Citation Data Be Submitted? mission1/



ACUTE TESTING:
81-1
81-2
81-3
81-4
Ln
ON 81-5
81-6
81-7
- Acute Oral Toxicity
- Rat
- Acute Dermal Toxicity
- Rabbit
- Acute Inhalation
Toxicity - Rat
- Primary Eye
Irritation
- Primary Dermal
Irritation
- Dermal Sensitization
- Acute Delayed
Neurotoxicity - Hen
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
A.B
A.B
A.B
A.B
A.B
A.B
A.B
No
No
No
No
No
No
Yes
Yes
Yes
Yes
Yes
Yes
Yes
0009391 5 No2/
9 Months
9 Months
9 Months
9 Months
9 Months
9 Months

SUBCHRONIC TESTING:
82-1
82-2
- 90-Day Feeding
- Rodent, and
- Nonrodent (Dog)
- 21 -Day Dermal - Rabbit
TGAI
TGAI
TGAI
A.B
A.B
A.B
No
to
No
Yes3/
Yes
15 Months
18 Months
12 Months

-------
                 TABLE A



GENERIC DATA REQUIREMENTS FOR CHLQRFRDFHAM

S158.
82-3
82-4
82-5
82-X
Data Requirement
Does EPA Have Data
To Satisfy This
Test Use Requirement? (Yes, Bibliographic
Substance Patterns No or Partially) Citation
Must Additional
Data Be Submitted Timeframe
Must Additional for Sub-
Data Be Submitted? mission)/
.135 Toxicology (continued)
- 90-Day Dermal
- Rabbit
- 90-Day Inhalation
- Rat
- 90-Day Neurotoxicity
- Hen/ Mammal
- Smoke Inhalation
TGAI A.B No
TGAI A.B No
TGAI A.B No
TGAI B Partially 00126737
NbV
NoV
•*/
Yes?/



15 Months
CHRONIC TESTING:
83-1
83-2

83-3
- Chronic Toxicity -
2 Species:
- Rodent, and
- Nonrodent (Dog)
- Oncogenicity
2 Species:
- Rat (Preferred).
and
- Mouse (Preferred)
- Teratogenicity
2 Species:
- Rat
- Rabbit
TGAI A.B No
TGAI A.B No
TGAI A.B No
TGAI A.B No ' *
TGAI A.B Yes 00093921
TGAI A.B Yes 00129940
Yes
Yes
Yes
Yes
No
No
50 Months
50 Months
50 Months
50 Months


-------
                                                       TABLE A

                                      GENERIC DATA REQUIREMENTS FOR CHLORFROPHAM
                                                    Does EPA Have Data
                                                    To Satisfy This                                          Timefrane
                               Test         Use     Requirement? (Yes,  Bibliographic  Must Additional       for Sub-
      Data Requirement       Substance    Patterns  No or Partially)    Citation       Data Be Submitted?    missionV
SI58.135 Toxicology (continued)

83-4 - Reproduction - Rat
         2-Generation

MUTAGEKICITY TESTING

84-2 - Gene Mutation
TCAI
A.B
Yes

84-2
84-2
(Ames Test)
- Structural Chromosomal
Aberration
- Other Mechanisms of
Mutagenicity
TGAI
TGAI
TGAI
A.B
A.B
A.B
Ye<
No
No
<-n SPECIAL TESTING
GO
85-1
85-2
86-1

- General
Metabolism PAI or PAIRA
- Dermal Absorption
- Domestic Animal
Safety
- Additional Test
Data
Choice
Choice
Choice
A.B
A.B
A.B
A.B
No
No
No
No
00129545
                                                                        00129938
No
                                                           No


                                                           Yes


                                                           Yes
                                                                                           Yes

                                                                                           Nofy
                                                                                                          12 Months


                                                                                                          12 Months
                                                                          24 Months

-------
                                                          TABLE A

                                         GENERIC DATA REQUIREMENTS FDR CHUORPRQPHAM
   S158.135 Toxicology Footnotes

   \J  Data must be submitted within the indicated t iroeframes, which begin on the date of the Guidance Document
       (See front cover for this date).

   2/  The  test is required only for organophosphates, metabolites, or other potential inhibitors of cholinesterase.
       Chlorpropham does not fit these criteria; therefore, a study is not required.

   y  This requirement is waived based on submission of an acceptable chronic feeding study in the rat/dog.

   4/  This study is not required because existing acceptable end uses should not result in repeated human skin
       contact.

   5/  This study is not required because existing acceptable end uses should not result in repeated human inhalation
       exposure.

   6/  Since an acute neurotoxicity study is not required for this compound, and there is not evidence of
       neurotoxicity in mammalian species, this study is not required.

   l_l  The requirements for smoke inhalation studies are included under "Special Testing" in these tables.
Ln
M)8/  No data are required under current use patterns.

   9/  If residues on tobacco greater than 0.1 ppm are detected, then an additional smoke inhalation study will be
       required.  However, since formal guidelines for such a study have not been developed, the registrant should
       consult with the Agency before performing the study.

   10/ If the required metabolism studies indicate that p-methoxy-chlorpropham (a metabolite of chlorpropham in
       potatoes) is not a metabolite in chlorprophara-dosed rats, then Guideline studies 81-1 (rat), 82-1  (rat only),
       83-3 (rat only), and 84-2 may be required on p-methoxy-chlorpropham.   However,  toxlcity studies on
       p-methoxy-chlorpropham are not required at this tine.

-------
                                                        TABLE A

                                       GENERIC DATA REQUIREMENTS FDR CHLORPROPHAM
Data Requirement
SI 58. 130 Environmental Fate
DEGRADATION STUDIES-LAB:
161-1 - Hydrolysis
Pho todegradat ion
161-2 - In Water
161-3 - On Soil
161-4 - In Air
METABOLISM STUDIES-LAB:
162-1 - Aerobic Soil
ON
0 162-2 - Anaerobic Soil
162-3 - Anaerobic Aquatic
163-4 - Aerobic Aquatic
MOBILITY STUDIES:
Test
Substance
PAIRA
•
PAIRA
PAIRA
PAIRA
PAIRA
PAIRA
PAIRA
PAIRA

Does EPA Have Data
To Satisfy This
Use Requirement? (Yes,
Patterns No or Partially)
A,B Yes

A.B No
A,B No
	
A,B No
A.B No
	
	

Bibliographic Must Additional
Citation Data Be Submitted?
00114729 No

Yes 9
Yes 9
No2/
Yes 27
Yes 27
No3/
Reserved^/

Timefraroe
for Sub-
mission^/


Months
Months

Months
Months



163-1 - Leaching and
          Adsorption/
          Desorption
PAIRA
A,B
No
Yes
7 Months

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                                                        TABLE A

                                       GENERIC DATA REQUIREMENTS FOR CHLORPROFHAM
Data Requirement
SI 58. 130 Environmental Fate
163-2 - Volatility (Lab)
163-3 - Vblatility (Field)
DISSIPATION STUDIES-FIELD:
164-1 - Soil
164-2 - Aquatic (Sediment)
164-3 - Forestry
164-5 - Soil, Long-Tern
ACCUMULATION STUDIES:
165-1 - Rotational Crops
(Confined)
165-2 - Rotational Crops
(Field)
165-3 - Irrigated Crops
165-4 - In Fish
Test
Substance
(continued)
TEP
TEP
TEP
TEP
TEP
TEP
PAIRA
TEP
TEP
PAIRA
Does EPA Have Data
To Satisfy This
Use Requirement? (Yes,
Patterns No or Partially)
A.B No
A,B N>
A.B No
	
	
A,B No
A No
A No
A No
A,B Partially
Bibliographic Must Additional
Citation Data Re Submitted?
Yes
Reserved^/
Yes
Nq3/
Nq3/
Reserved^/
Yes
Reserved 7 /
Yes§/
00035997 Yes
00035998
Timefraroe
for Sub-
mission^/
12 Months

27 Months


50 Months
39 Months
50 Months
39 Months
12 Months
165-5 - In Aquatic Nontarget
          Organisms
TEP
A,B
No
Reserved^/

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                                                           TABLE A

                                          GENERIC DATA REQUIREMENTS FOR CHLORFROPHAM
   SI58.130 Environmental Fate Footnotes

   ]_/  Data must be submitted within indicated tiroeframes,  which begin on the date of the Guidance Document
       (see front cover for this date).

   2J  Data are not normally requested unless this chemical has a high vapor pressure (>10~6 mmHg) and there are
       toxicological and rentry concerns.

   y  Data are not required for use pattern.

   4/  Reserved pending evaluation of acceptable aerobic metabolism data (cranberry use).

   V  Reserved pending results of laboratory volatility data and review of toxicological and reentry issues.

   6/  Reserved pending results of field dissipation study.

   TJ  Reserved pending results of confined rotational crop study.

   8/  Data are required for the registered cranberry use.

   9/  Reserved pending ecological issues  and fish accumulation data.
ON

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                                                        TABLE A

                                       GENERIC  DATA REQUIREMENTS FOR CHLORPROPHAM
    Data Requirement
  Test       Use
Substance  Patterns
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted?
Timeframe
    for   J/
Submission
SI 58. 140 Reentry Protection

132-1 - Foliar Dissipation TEP No

132-1 - Soil Dissipation TEP No

132-3 - Dermal Exposure ' TEP No
132-4 - Inhalation Exposure TEP No
$158.142 Spray Drift
201-1 - Droplet Size Spec t run A,B. No
201-1 - Drift Field Evaluation A,B. No

2/
No
2/
No
2/
No
No~

No~
No~
J_/ Data must be submitted within indicated timeframes, which begin on the date of  the Guidance  Document
   (see front cover for this date).

2J lexicological data do not indicate a need for reentry data.

3/ No apparent issues have been raised with present registered uses to require spray drift data.

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                  TABLE A




GENERIC DATA REQUIREMENTS FDR CHLORPROPHAM
Test
Data Requiranent Substance
$158
Does EPA Have Data
To Satisfy Require- Timeframe
Use ment? (Yes. No or Bibliographic Must Additional for Sub-
Patterns Partially) Citation Data Be Submitted? mission1/
.145 Wildlife and Aquatic Organisms
SPECIAL TESTING
70-1
- Residue Monitoring
TEP
A.B.C
No
2/
Yes"
9 Months
AVIAN AND MAMMALIAN TESTING
71-1

71-2
71-3
71-4
71-5


- Acute Avian Oral
Toxicity
- Avian Subacute Dietary
- upland Game Bird
- Waterfowl
- Wild Mammal Toxicity
- Avian reproduction
- upland Game Bird
- Waterfowl
- Simulated and Actual
Field Testing
- Mammals
- Birds
- Actual Field Testing
- Mammals
- Birds

TCAI
TGAI
TGAI
TGAI
TGAI
TGAI

TEP
TEP
TEP
TEP

A.B.C
A.B.C
A.B.C
A.B.C
A.B.C
A.B.C

A.B.C
A.B.C
A.B.C
A.B.C

No
No
No
No
No
No

No
No
No
No

Yes
Yes
Yes
No
Reserved^/
Reserved^/

Reserved4/
Reserved**/
Reserved^/
Reserved2*/

9 Months
9 Months
9 Months






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                                                              TABLE A

                                            GENERIC DATA REQUIREMENTS FDR CHLORFROFHAM
           Data Requirement
                       Does ERA Have Data
                       To Satisfy Require-
  Test          Use    merit?  (Yes, No or
Substance     Patterns Partially)
                Bibliographic
                Citation
                 Mist Additional
                 Data Be Submitted?
                Timeframe
                for Sub-
                mission^ /
     S158.145 Wildlife and Aquatic Organisms (continued)

     AQUATIC ORGANISM TESTING

     72-1  -  Freshwater Fish  Toxicity
            - Coldwater Fish Species,   TGAI        A,B,C
                                       TEP         A,B,C
                                       Degradation
                                         Product    A.B.C
O\
            - Warmwater  Fish
               Species
     72-2  - Acute Toxicity
              to Freshwater
              Invertebrates
     72-3  - Acute Toxicity  to
              Estuarine and
              Marine Organisms
              -  Fish
    TGAI        A.B.C
    TEP         A.B.C
    Degradation
      Product   A.B.C
    TGAI        A.B.C
    TEP         A.B.C
    Degradation
      Product   A.B.C
    TGAI        A.B.C
    TEP         A.B.C
    Degradat ion
      Product   A.B.C
                            Yes
                            No

                            No
Yes
No

No
No
No

No
No
No

No
              40208604
                      No
                      Yes
                                  Reserved^/
40208603
No
Yes
                                                                                                 Reserved^/
                      Yes
                      Yes
                                                                                                 Reserved^/
                      Yes
                      Yes

                    Reserved^/
                                                     9 Months
                                                                                                                   9 Months
                9 Months
                9 Months
               12 Months
               12 Months

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                                                         TABLE A

                                       GENERIC DATA REQUIREMENTS FOR CHLORPROPHAM
      Data Requirement
                       Does EPA Have Data
                       To Satisfy Require-
  Test          Use    ment?  (Yes, No or
Substance     Patterns Partially)
                                                                               Bibliographic
                                                                               Citation
                                Must Additional
                                Data Be Submitted?
                                                                                                               Timefrane
                                                                                                               for Sub-
S158.145 Wildlife and Aquatic Organisms (continued)

72-3 - Acute Tbxicity to
         Estuarine and
         Marine Organisms
         (cont'd)
         - Mollusk                TGAI        A.B.C
                                  TEP         A.B.C
                                  Degradation
                                    Product   A.B.C
         - Shrimp
    TGAI        A.B.C
    TEP         A.B.C
    Degradation
      Product   A.B.C
    72-4 - Fish and Early Life Stage
             and Aquatic Invertebrate
gs           Life Cycle
             - Freshwater Species
         - Estuarine/Marine
             Species
72-5 - Fish Life Cycle
    TGAI        A.B.C
    Degradation
      Product   A.B.C

    TGAI        A.B.C
    Degradation
      Product   A.B.C
                                                              No
                                                              No

                                                              No

                                                              ND
                                                              No

                                                              No
    TGAI
                                                  A.B.C
No

No

ND

No

No
                                                                 Yes
                                                                 Yes
                                                               Reserved^/
                                     Yes
                                     Yes
                                                                                             Reserved^/
  Yes

Reserved^/

  Yes

Reserved^/

  Yes
                                                    12 Months
                                                    12 Months
                 12 Months
                 12 Months
                                                                                                              15 Months
                                                                                                                  15 Months
27 Months

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                                                             TABLE A

                                           GENERIC DATA REQUIREMENTS FOR CHI/)RPROPHAM
ON
Does EPA Have Data
Tb Satisfy Require- Timeframe
Test Use ment? (Yes, No or Bibliographic Must Additional for Sub-
Data Requirement Substance Patterns Partially) Citation Data Be Submitted? mission1/
S158.
72-6





145 Wildlife and Aquatic Organisms (continued)
- Aquatic Organism
Accumulation TEP A.B.C
Degradation
Product A.B.C
- Crustacean No
- Fish No
- Insect Nymph No
- Mollusk No
- Shrimp No

Reserved**/
Reserved*^/
Reserved**/
Reserved**/
Reserved**/
                  Testing
  - Aquatic Organisms

- Actual Field Testing
  - Aquatic Organisms
TEP


TEP
                                                  A.B.C


                                                  A.B.C
No


No
Reserved^/


Reserved^/

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                                                          TABLE A

                                         GENERIC DATA REQUIR01ENTS FOR CHLORFROPHAM
   S158.145 Wildlife and Aquatic Organisms Footnotes

   jy  Data must be submitted within the indicated timeframes, which begin on the date of the Guidance Document
       (see front cover for this date).

   2J  Residue monitoring must be conducted on terrestrial food crop, and aquatic crop use
       sites using the highest registered rates for each.  The studies must be conducted on alfalfa, onion,
       blueberry, and cranberry crop sites.  Terrestrial and aquatic monitoring must be conducted on each crop in
       locations where climatic conditions are favorable to the type of monitoring.  A minimum of three terrestrial
       monitoring studies (five sites per crop) must be conducted on alfalfa, onions, and blueberries.  A minimum of six
       aquatic residue monitoring studies (five sites per crop) must be conducted on alfalfa, cranberries and blueberries.
       Terrestrial site selection rationale must include agricultural areas where limited rainfall conditions favor the
       persistence of residues in terrestrial environments.  Aquatic site selection rationale include be in those areas
       where rainfall conditions favor the movement of residues into aquatic environments in or near the test agricultural
       site.  Alfalfa and cranberry sites must include residue monitoring from aerial applications where drift to adjacent
       terrestrial and aquatic environments can be monitored.  Residue sampling parameters must include water, sediment,
       foliage, fish, insects, invertebrates, small mammals, birds, and pertinent feed and habitat items.  Residue
       monitoring study protocols must be submitted within 90 days.  Progress reports must be submitted at 6-month
       intervals.

   _3/  Avian reproduction studies are reserved pending the results of the avian acute toxicity, residue monitoring,
       and environmental fate studies.
CO
   4/  Field study requirements are reserved pending the results of acute avian oral, avian subacute dietary, freshwater
       fish toxicity, acute toxicity to freshwater invertebrates, acute toxicity to estuarine and marine organisms,
       avian reproduction, fish and early life stage and aquatic invertebrates, fish life cycle, residue monitoring, and
       environmental fate studies.

   5/  Degradation studies are reserved pending the results of environmental fate studies.
                                                                                 t
   61  Aquatic organism accumulation studies are reserved pending the results of the environmental fate and residue
       monitoring studies.

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                 TABLE A



GENERIC DATA REQUIREMENTS FOR CHLDRPPOPHAM

SI 58.
Test
Data Requirement Substance
150 Plant Protection
121-1 - TARGET AREA
PHYTOTOXICITY EP
NONTARGET AREA PHYTOTQXICITY
121-1
122-1
Ox 122-2
123-1
123-1
123-2
TIER I
- Seed Germination/
Seedling Emergence TGAI
- Vegetative Vigor TGAI
- Aquatic Plant Growth TGAI
TIER II
- Seed Germination/
Seedling Emergency TGAI
- Vegetative Vigor TGAI
- Aquatic Plant Growth TGAI
Does EPA Have Data
To Satisfy Requ ire-
Use ment? (Yes, No or Bibliographic Must Additional
Patterns Partially) Citation Data be Submitted?
A.B.C No NojV
A,B,C No Yes
A.B.C No Yes
A,B,C No Yes
A.B.C No Nq2/
A.B.C No Nb£/
A.B.C No » Nb2/
Timeframe
for Sub-
mission^/
9 Months
9 Months
9 Months

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                                                       TABLE A

                                      GENERIC DATA REQUIREMENTS FDR CHLORPROPHAM
      Data Requirement
                       Does EPA Have Data
                       To Satisfy Require-
  Test          Use    went?  (Yes, No or
Substance     Patterns Partially)
                 Bibliographic  Must Additional
                 Citation       Data Be Submitted?
                 Timeframe
                 for Sub-
                 miss ionl /
SI58.150  Plant Protection (continued)

         TIER III

124-1 - Terrestrial Field        TEP

124-2 - Aquatic Field            TEP
               A.B.C

               A.B.C
No

No
Nq£/

No2/
\J  Data must be submitted within the indicated timeframes, which begin on the date of  the Guidance Document
    (see front cover for this date).
2_/  These requirements are generally waived unless it is believed there is a phototoxicity  problem,

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                                                            TABLE A

                                          GENERIC DATA REQUIREMENTS FOR CHLORPROFHAM
         Data Requirement
                       Does EPA Have Data
                       To Satisfy This
  Test         Use     Requirement? (Yes,
Substance    Pattern   No or Partially)
              Bibliographic
              Citation
           Must Additional
           Data Be Submitted?
                Tiroeframe
                for Sub-
                mission^ /
   8158.155 Nontarget Insect
   NONTARGET INSECT TESTING -
   POLLINATORS;

   141-1  - Honey Bee Acute
             Contact Toxicity        TGAI

   141-2  - Honey Bee - Toxicity
             of Residues on
             Foliage                 TEP

   141-4  - Honey Bee Subacute
             Feeding Study

1^141-5  - Field Testing for
             Pollinators             TEP

   NONTARGET INSECT TESTING - AQUATIC INSECTS;

   142-1  - Acute Toxicity to
             Aquatic Insects

   142-2  - Aquatic Insect Life
             Cycle Study

   142-3  - Simulated or Actual
             Field Testing for
             Aquatic Insects
                 A.B.C.G
                 A.B.C.G
Yes
No
                 A.B.C.G
No
00018842
  No



  No?/


Reserved^/


  NojV




Reserved^/


Reserved^/



Reserved^/

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                                                         TABLE A

                                       GENERIC DATA REQUIREMENTS FDR CHLORPROPHAM
                                                    Does EPA Have Data
                                                    To Satisfy This                                         Tiraeframe
                               Test         Use     Requirement? (Yes,  Bibliographic  Must Additional      for  Sub-
      Data Requirement       Substance    Patterns  No or Partially)    Citation       Data Be Submitted?   mission]/


SI58.155 Nontarget Insect (continued)

143-1 - NONTARGET INSECT                                                                    Reserved*/
thru    TESTING - PREDATORS
143-3 - AND PARASITES
\J  Data roust be submitted within the indicated timeframes, which begin on the date of the Guidance Document
    (see front cover for this date).

21  As data from the acute contact test indicate low toxicity, no further testing is required.

_3/  Reserved pending development of test methodology.

4/  Reserved pending Agency decision as to whether the data requirement should be established.

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                                                           TABLE B

                  PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPROPHAM
CA!
Test
Data Requirement Substance
SI 58. 120 Product Chemistry
Product Identity and Composition
61-1 - Product Identity
and Disclosure of •
Ingredients MP
61-2 - Description of Beginning
Materials and Manufac-
turing Process MP
61-3 - Discussion of Formation
of Impurities MP
Analysis and Certification of
Product Ingredients
Does EPA Have Data
To Satisfy Require- Timeframe
ment? (Yes, No or Bibliographic Must Additional for
Partially) Citation £/ Data Be Submitted? Submission^/
No N/A YesJV 6 Months
No N/A YesV 6 Months
No N/A YesV 6 Months

    62-1  - Preliminary Analysis       MP
    62-2  - Certification of
              Limits                   MP

    62-3  - Analytical Methods
              to Verify Certified
              Limits                   MP
No
No
No
N/A
N/A
N/A
Yesfy
Yes?/
Yes8/
12 Months
12 Months
12 Months

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                                                       TABLE B

              PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE  PRODUCTS CONTAINING CHLORPROPHAM
Test
Data Requirement Substance
Does EPA Have Data
To Satisfy Require-
ment? (Yes, No or Bibliographic
Partially) Citation 2/
Timeframe
Must Additional for
Data Be Submitted? SubmissionV
$158.120 Product Chemistry (continued)
Physical and Chemical Characteristics
63-2
63-3
63-4
63-7
63-12
63-14
63-15
63-16
63-17
63-18
63-19
- Color
- Physical State
- Odor
- Density, Bulk Density,
or Specific Gravity
-pH
- Oxidizing or Reducing
Action
- Flanmability
- Explodability
- Storage Stability
- Viscosity
- MIscibility
MP
MP
MP
MP
MP
MP
MP
MP
MP
MP
MP
No
No
No
No
No
No
No
No
No
No
No
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Yes9/
Yes9/
YesjV
Yes9/
Yes?/, JO/
Yes9/.jMy
Yes£/,_[2/
YesjV J3/
YesjV
YesjV.JV
YesjV.Jjy
6 Months
6 Months
6 Months
6 Months
6 Months
6 Months
6 Months
6 Months
15 Months
6 Months
6 Months
63-20 - Corrosion
          Characteristics
MP
No
N/A
Yes9/
15 Months

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                                                       TABLE B

              PRODUCT SPECIFIC DATA REQUIREMENTS TOR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPROPHAM
      Data Requirement
  Test
Substance
Does EPA Have Data
To Satisfy Require-
ment?  (Yes. No or
Partially)
Bibliographic
Citation 2/
                    Timefrane
Must Additional        for
Data Be Submitted?  Submission1/
SI58.120 Product Chemistry (continued)

Other Requirements;

64-1  - Submittal of Samples       N/A
                       N/A
                       N/A
                     N/A

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                                                       TABLE B

              PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPROPHAM


SI58.120 Product Chemistry Footnotes

\J  Data must be submitted within the indicated timeframes,  which begin on the date of the Guidance Document
    (see front cover for this date).

21  Not applicable.  Although product chemistry data may have been  submitted  in the past,  the Agency has determined
    that these data must be resubmitted for each pesticide.   New requirements have  been introduced and previously
    submitted data must be updated.  Therefore, bibliographic citations for the old data are not applicable.

3/  The chemical name and nominal concentration of each impurity for which a  certified limit is required must be
    submitted.  In addition, the chemical name, nominal concentration,  Chemical Abstracts (CAS) Registry Number, and
    purpose of the active ingredient and each intentionally  added inert must  be provided.   For the active ingredient,
    the following must also be provided:  the product name,  trade name, and cannon  name;  the molecular, structural,
    and empirical formulas; die molecular weight or weight range; and  any experimental or internally assigned company
    code numbers.

4/  Complete information must be provided regarding the nature of the  process (batch or continuous), the relative
    amounts of beginning materials and the order in which they are  added,  die chemical equations for each intended
    reaction, equipment used to produce each intermediate and final product,  reaction  conditions,  the duration of
    each step of the process, purification procedures,  and quality  control measures.   In addition, the name and
    address of die manufacturer, producer, or supplier  of each beginning material must be provided, along with
    information regarding die properties of each beginning material used  to manufacture each product.

5/  A detailed discussion of all impurities diat are or may  be present at  *>_ 0.1%, based on knowledge of die beginning
    materials, chemical reactions (intended and side) in die manufacturing process, and any contamination during and
    after production must be submitted.
                                                                                    I
6/  Five or more representative samples must be analyzed for the amount of active ingredient and each impurity
    for which a certified limit is required.   Complete  validation data (accuracy, precision)  must  be submitted for
    each analytical method used.                                            *

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                                                       TABLE B

              PRODUCT SPECIFIC DATA RBQUIREnENTS FOR HftNUFACTLRING-USE PRODUCTS CONTAINING CHLORPROPHAM


SI58.120 Product Chemistry Footnotes (cont'd)

TJ  Upper and lower limits for the active ingredient and each intentionally added inert, and upper limits for each
    impurity present at ^ 0.1% (w/w) and each "toxicologically significant" impurity present at < 0.1% (w/w) must be
    provided, certified, and validated by sample analysis using analytical procedures for which accuracy and precision
    data have been provided.  Limits for impurities not associated with the active ingredient need be provided only
    if they are considered to be of toxicological significance, regardless of the concentration at which they are
    present.  Certifications must be submitted on EPA Form 8570 (Rev. 2-85).

J}/  Analytical methods must be provided to determine the active ingredient, and each toxicologically significant
~   impurity and intentionally added inert for which certified limits are required and each toxicologically significant
    impurity (unintentionally) added at > 0.1%.  Each method must be accompanied by validation studies indicating its
    accuracy and precision.  These method's must be suitable for enforcement of certified limits.
9/  Physicochanical characteristics (color, physical state, odor, specific gravity, pH, oxidizing or reducing action,
    flammability, explodability, storage stability, viscosity, miscibility, and corrosion characteristics) as required
    in 40 CFR 158.120 and more fully described in the Pesticide Assessment Guidelines, Subdivision D must be submitted.

_10/ Required if the test substance is dispersible with water.

11/ Required if the product contains an oxidizing or reducing agent.

J2/ Required if the product  contains combustible liquids.

13/ Required if the product is potentially explosive.

14/ Required if the product is a liquid.

15/ Required if the product is a liquid and is to be diluted with petroleum solvents.

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                                                      TABLE B

              PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE  PRODUCTS CONTAINING CHLORPROPHAM
Does EPA Have Data
To Satisfy Require- Timeframe
Test ment? (Yes, No or Bibliographic Must Additional for
Data Requirement Substance Partially) Citation Data Be Submitted? Submission^
SI 58. 135 Toxicology
ACUTE TESTING:
81-1 - Acute Oral - Rat MP No
81-2 - Acute Dermal MP No
81-3 - Acute Inhalation MP No
81 -A - Eye Irritation - Rabbit MP No
81-5 - Dermal Irritation -
Rabbit MP No
0° 81-6 - Dermal Sens itizat ion -
Guinea Pig MP No


Yes 6 Months
Yes 6 Months
Yes 6 Months
Yes 6 Months

Yes 6 Months

Yes 6 Months
\j  Data must be submitted within the  indicated timefraraes, uhich begin on the date of  the Guidance Document
    (see front cover for this date).

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APPENDIX II



  LABELING

-------
                          SUMMARY-1

                        LABEL CONTENTS

      40 CFR  162.10 requires that certain specific  labeling
 statements appear at certain locations on the label.   This
 is  referred  to as format labeling.  Specific label items  listed
 below are keyed to the table at the end of this Appendix.

      Item 1.  PRODUCT NAME - The name, brand or trademark is
 required to be located on the front panel, preferably centered
 in  the  upper part of the panel.  The name of a product will
 not be  accepted if it is false or misleading.

      Item 2.  COMPANY NAME AND ADDRESS - The name  and address
 of  the  registrant or distributor is required on the label.
 The name and address should preferably be located  at the
 bottom  of the front panel or at the end of the label text.

      Item 3.  NET CONTENTS - A net contents statement is
 required on all labels or on the container of the  pesticide.
 The preferred location is the bottom of the front  panel
 immediately above the company name and address, or at the end
 of  the  label text.  The net contents must be expressed in the
 largest suitable unit, e.g., "1 pound 10 ounces" rather than~
 "26 ounces." In addition to English units, net contents may
 be expressed in metric units.  [40 CFR 162.10(d)J

      Item 4.  EPA REGISTRATION NUMBER - The registration
 number  assigned to the pesticide product must appear on the
 label,  preceded by the phrase "EPA Registration No.," or "EPA
 Reg.  No."  The registration number must be set in type of a
 size  and style similar to other print on  that  part of the
 label on which it appears and must run parallel to it.  The
 registration number and the required  identifying  phrase must
 not appear in such a manner as to suggest or  imply recommendation
 or  endorsement of the product by  the Agency.
 [40 CFR 162.10(e)J

    Item 5.  EPA ESTABLISHMENT NUMBER  - The  EPA establishment
 number, preceded by Che phrase "EPA Est." is  the  final estab-
 lishment at which the product was  produced,  and may  appear
 in any  suitable location on the label  or  immediate  container.
 It must also appear on the wrapper or  outside container  of
 the package if the EPA establishment number  on the  immediate
container cannot be clearly read  through  such wrapper or container.
 [40 CFR 162.10(f)J

    Item 6A. INGREDIENTS STATEMENT - An  ingredients  statement
 is required on the front panel.   The  ingredients  statement must
contain the name and percentage by weight of each active ingredient
and the total percentage by weight of  ail inert ingredients.
The preferred location is immediately  below the product  name.
The ingredients statement muse run parallel with, and be clearly
distinguished from, other text on the panel.  It  must not be
placed  in the body of other text.   [40 CFR  162.10(g)]

                                       79

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                            SUMMARY-2

     Item 6B.  POUNDS PER GALLON STATEMENT -  For  liquid agricul-
 tural  formulations, the pounds per gallon of active  ingredient
 must be indicated on the label.

     Item 7.  FRONT LABEL PRECAUTIONARY STATEMENTS  -  Front panel
 precautionary statements must be grouped  together, preferably
 within a block outline.  The table below shows  the minimum  type
 size requirements for various size labels.

     Size of Label        Signal Word          "Keep  Out  of  Reach
     on Front Panel       Minimum Type Size       of  Children"
     in Square Inches     All Capitals          Minimum Type Size

    5  and under                6 point              6 point
    above 5 to 10             10 point              6 point
    above 10 to 15            12 point              8'point
    above 15 to 30            14 point             10 point
    over 30                   18 point             12 point

    Item 7A.  CHILD HAZARD WARNING STATEMENT -  The statement
"Keep  Out of Reach of Children" must be located on the  front
panel  above the signal word except where contact with children
during distribution or use is unlikely.  [40 CFR 162.10(h)(1)(li)]

    Item 7B.  SIGNAL WORD - The signal word (DANGER, WARNING,
or CAUTION)  is required on the front panel immediately  below
the child hazard warning statement.  [40 CFR 162.10 (h)(l)(i)]

    Item 7C.  SKULL & CROSSBONES AND WORD "POISON" - On products
assigned a toxicicy Category I on the basis of oral, dermal,
or inhalation toxicicy, the word "Poison" shall appear  on the
 label  in red on a background of distinctly contrasting color and
the skull and crossbones shall appear  in  immediate proximity to
 the word POISON.  [40 CFR 162.10(h)(1)(i)]

     Item 7D.  STATEMENT OF PRACTICAL TREATMENT  - A statement
of practical treatment (first  aid or  other)  shall appear on
the label of pesticide products in  toxicity  Categories  I,
II, and III.  [40 CFR 162.10(h)(1)(iii)]

     Itea 7E.  REFERRAL STATEMENT  -  The statement  "See Side
(or Back) Panel for Additional  Precautionary Statements"  is
required on the front panel  for all products,  unless all
required precautionary statements  appear on the front  panel.
 [40 CFR 162.10(h)(l)(iii)J

     Item 8.  SIDE/BACK PANEL PRECAUTIONARY  LABELING -  The
precautionary statements listed below must  appear together
on the label under the heading "PRECAUTIONARY  STATEMENTS."
The preferred location is at the  top of  the side or back
panel  preceding the directions for use,  and it is preferred
that these statements be surrounded by a block outline.  Each
of the three hazard warning  statements must be headed  by the
appropriate hazard title.   [40 CFR 162.10(h)(2)].

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                          SUMMARY-3

     Item 8A.  HAZARD TO HUMANS AND DOMESTIC ANIMALS  - Where a
 hazard  exists Co humans or domestic animals, precautionary
 statements are required indicating the particular hazard, the
 route(s) of exposure and the precautions to be taken to  avoid
 accident, injury or damage.  [40 CFR 162.10(h)(2)(i)]

     Item 8B.  ENVIRONMENTAL HAZARD - Where a hazard  exists  to
 non-target organisms excluding humans and domestic animals,
 precautionary statements are required stating the nature of
 the  hazard and the appropriate precautions to avoid  potential
 accident, injury, or damage.  [40 CFR 162.10(h)(2)(ii)]

     Item 8C.  PHYSICAL OR CHEMICAL HAZARD - FLAMMABILITY
 Precautionary statements relating to flammability of a product
 are  required to appear on the label if it meets the criteria
 in the  PHYS/CHEM Labeling Appendix. The requirement is
 based on the results of the flashpoint determinations and
 flame extension tests required to be submitted for all products.
 These statements are to be located in the side/back panel
 precautionary statements section, preceded by the heading
 "Physical/Chemical Hazards."  Note that no signal word is
 used in conjunction with the flammability statements.

     Item 9A.  RESTRICTED USE CLASSIFICATION - FIFRA sec. 3(d)
 requires that all pesticide formulations/uses be  classified
 for either general or restricted use.  Products classified
 for  restricted use may be limited to use by certified applicators
 or persons under their direct supervision (or may be subject
 to other restrictions that may be imposed by regulation).

     In the Registration Standard, the Agency has  (1) indicated
 certain formulations/uses are to be restricted (Section  IV
 indicates why the produce has been classified for restricted
 use); or (2) reserved any classification decision until
 appropriate data are submitted.

    The Regulatory Position and Rationale  states  whether
products containing this active ingredient  are classified
 for  restricted uae.  If they are restricted the  draft label(s)
submitted to Che Agency as part of your application must
 reflect this determination (see below).

     If you do noc believe that your  product  should  be  classified
 for  restricted use, you must submit  any  information and
rationale with your application for  reregistration.   During
 the Agency's review of your application,  your proposed  classi-
 fication determination will be  evaluated  in accordance  with
 the. provisions of 40 CFR 162.11(c).   You  will be notified  of
 the Agency's classification decision.
                                       81

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                          SUMMARY-5

     Icetn  10A.  REENTRY STATEMENT - If a reentry interval
 has  been  established by the Agency, it must be included on
 the  label.  Additional worker protection statements may be
 required  in accordance with PR Notice 83-2, March 29, 1983.

     Item  10B.  STORAGE AND DISPOSAL BLOCK -  All labels are
 required  to bear storage and disposal statements.  These
 statements are developed for specific containers, sizes, and
 chemical  content.  These instructions must be grouped and
 appear under the heading "Storage and Disposal" in the directions
 for  use.  This heading must be set in the same type sizes as
 required  for the child hazard warning.  Refer to Appendix II,
 STOR, PEST/DIS, and CONT/DIS to determine the storage and
 disposal  instructions appropriate for your products. '

     Item  IOC.  DIRECTIONS FOR USE - Directions for use must
be stated in terms which can be easily read and understood by
 the  average person likely to use or to supervise the use of
 the pesticide.  When followed,- directions must be adequate to
protect the public from fraud and from personal  injury and to
prevent unreasonable adverse effects on the environment.
 [40 CFR 162.10]


                     COLLATERAL LABELING

     Bulletins, leaflets, circulars, brochures, data  sheets,
flyers, or other written or graphic printed matter which  is
referred  to on the label or which is to accompany the  product
are  termed collateral labeling.  Such labeling may not bear
claims or representations chat differ in substance  from  those
accepted  in connection with registration of the  product.  It
should be made part of the response to this notice  and submitted
for review.
                                        82

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                  SIM1ARY-6
LABELING REQUIREMENTS OF THE FIFRA, AS AMENDED
ITEM
1
2
3
4
5
6A
6B
>
VA
>B
LABEL ELEMENT
Product name
Company name
and address
Net contents
EPA Reg. No.
EPA Est. No.
Ingredients
statement
Pounds/gallon
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where dosage
given as Ibs.
ai/unit area
All products
All products
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
None
None
None
None
Front panel
Front panel
Front panel
Front panel
Front panel
FKEKEKKKU
Center front
Bottom front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel,
immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the main
ingredients
statement
V
Above signal
word
i
Immediately
below child
hazard
warning
COMMENTS

If registrant is not the producer, roust
be qualified by "Packed for . .
"Distributed by. . .," etc.
May be in metric units in addition to
U.S. units
Must be in similar type size and run
parallel to other type.
May appear on the container instead of
the label.
Text must run parallel with other text
on the panel.

All front panel precautionary statements
must be grouped together, preferably
blocked.
Note type size requirements.
Note type size requirements.

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                                                           SIM1ARY-7
ITEM
1C
7D
7E
8
flA
8B
LABEL ELEMENT
Skull & cross-
bones and word
POISON (in red)
Statement of1
Practical
Treatment or
First Aid
Referral
statement
Side/back panel
precautionary
statements
Hazards to
humans and
domestic
animals
Environmental
hazards
APPLICABILITY
OF REQUIREMENT
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxicity
All products
in Categories
I. II. and III
All products
where pre-
cautionary
label ing
appears on
other than
front panel.
All products
All products
in Categories
I. II, and III
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
Category I:
Front panel
unless refer-
ral statement
is used.
Others:
Grouped with
side panel
precautionary
statements.
Front panel
None
None
None
PREFERRED
Both in close
proximity to
signal word
Front panel
for all.

Top or side
of back panel
preceding
directions
for use t
Same as above
Same as above
cortiEwrs

1

Must be grouped under the headings in
8A. 8B, and 8C; preferably blocked.
Mist be preceded by appropriate signal
word.
Environmental hazards include bee
caution where applicable.
00

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                                                        SUtlAKY-8
ITEM
sc
9A
9B
16A
10B
loc
LABEL ELEMENT
Physical or
chemical
hazards
Restricted
block
Misuse
statement
Reentry
statement
Storage and
disposal block
Directions
for use
APPLICABILITY
OF REQUIREMENT
All pressurized
products, others
with flash
points under
150°F
All restricted
products
All products
PR Notice 83-2
or as determined
by the Agency
All products
All products
PLACEMENT ON LABEL
REQUIRED
None
Top center
of front
panel
Immediately
following
heading of
directions
for use
In the
directions
for use
In the
directions
for use
None
PREFERRED
Same as above
Preferably
blocked

Immediately
after misuse
statement
Immediately
before
specific
directions
for use or
at the end of
directions
for use
None
COMMENTS
Refer to Appendix II guide
PHYS/CHEM
Includes a statement of the terms of
restriction. The words "RESTRICTED USE
PESTICIDE" must be sane type size as
signal word.
Required statement is:
"It is a violation of Federal law
to use this product in a manner
inconsistent with its labeling." .

Must be set apart and clearly distin-
guishable from from other directions
for use.
Refer to Appendix II guides STOR,
COOT/ D IS, and PEST/DIS for further
information and required statements.
May be in metric as well as U.S. units
00
tn

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 Chapter 1—Bavirouwntal Protection Agency
 5162.10  Lab*ling  requirements.

   (a)  General—(1)  Contents of the label.   Every pesticide
 product shall bear a label containing the information  specified by
 the Act and the regulations in this Part.  The contents of a
 label must show clearly and prominently the following:
   (i)  The name/ brand/ or trademark under which the'product is
 sold as prescribed in paragraph (b) of this section;
   (ii)   The name and address of the producer/ registrant/ or
 person for whom produced as prescribed in paragraph (c) of this
 section;
   (iii)   The-net contents as prescribed in paragraph (d) of this
 section;
   (iv)   The product registration number as prescribed  in paragraph
 (e)  of  this section;
   (v)   The producing establishment number as prescribed in para-
 graph (f)  of this  section;
   (vi)   An ingredient statement as prescribed in paragraph  (g)  of
 this  section;
   (vii) 'Warning or precautionary statements as prescribed  in'
 paragraph  (h)  of this section;
   (viii)   The  directions for use as prescribed in paragraph (i)
 of  this section; and
   (ix)  The use classification(s) as prescribed in paragraph (j)
 of  this section.
   (2)   Prominence  and legibility*  (i)  All words/ statements/
 graphic representations/ designs or other information required on
 the labeling by the Act or the regulations in this part must" be
 clearly legible to a person with normal vision/ and must be placed
 with  such  conspicuousness (as compared with other words/ state-
 ments/ designs/ or graphic matter on the labeling) and expressed
 in such terms  as to render it likely to be read and understood
 by the ordinary individual under customary conditions of purchase
 arid use.
  (ii)  All  required label text must:
  (A)  Be  set  in 6-point or larger type;
  (B)  Appear  on a clear contrasting background;  and
  (C)  Not be  obscured or crowded.
  (3)  Language to be used,.  All required  label or labeling text
shall appear in the English language.  However/ the Agency may
require or the applicant may propose additional text  in other
 languages  as is considered necessary to  protect the public,  when
additional  text in another language  is necessary* all labeling
 requirements will  be applied equally to  both the English and
other-language versions of the labeling.
  (4)  Placement of Label—(r)   General.   The label shall  appear
on or be securely  attached to  the  immediate container of  the
                                        86

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  pesticide product.  For purposes of this  Section, and the mis**
  branding provisions of the Act,  "securely attached" shall mean
  that a label can reasonably be expected to remain affixed during
  the foreseeable conditions and period  of  use.   If the immediate
  container is enclosed within a wrapper or outside container
  through which the label cannot be clearly read,  the label must
  also be securely attached to such outside wrapper or container,
  if it is a part of the package as customarily distributed or
  sold.
   (ii)   Tank cars and other bulk containers—(A)  Transportation.
 While a pesticide product is in  transit,  the appropriate
 provisions of 49 CPR Parts 170-189, concerning  the transportation
 of hazardous materials, and specifically  those  provisions con-
 cerning the labeling, marking and placarding of  hazardous materials
 and the vehicles carrying them,  define the basic Federal require-
 ments.   In addition, when any registered  pesticide product is
 transported in a tank car, tank  truck  or  other  mobile or portable
 bulk container,  a copy of the accepted label must be attached  to
 the shipping papers, and left with the consignee at the time of
 delivery.
   (B)   Storage.   When pesticide  products  are stored in bulk
 containers,  whether mobile or stationary, which remain  in the
 custody of  the user, a copy of the label  of labeling, including
 all appropriate  directions for use, shall be securely attached to
 the container in the immediate vicinity of the  discharge control
 valve.
   (5)   False or  misleading statements. Pursuant to section
 2(q)(l)(A)  of the Act, a pesticide or  a device  declared subject
 to the  Act  pursuant to S 162.15, is misbranded  if  its labeling is
 false or misleading in any particular  including both pesticidal
 and non-pesticidal claims.  Examples of statements or representations
 in  the  labeling  which constitute misbranding  includet
   (i)  A false or misleading statement concerning  the composition
 of the product;
   (ii)  A false  or misleading statement concerning  the  effectiveness
 of the product as a pesticide or device;
   (iii) . A  false or misleading statement  about  the  value  of  the
 product for  purposes other than  as a pesticide  or device;
   (iv)  A false  or misleading comparison  with other pesticides or
devices;
  (v)  Any statement directly or indirectly implying that the
pesticide or device is recommended or  endorsed by any agency of
 the Federal  GovernxMnt;
  (vi)   The  name of a pesticide  which  contains  two or more
principal active ingredients if  the name  suggests one or more but
not all such  principal active ingredients even though the names
of the other  ingredients are stated elsewhere in the labeling;
  (vii)  A true  statement used in such a  way as to give a falsa
or misleading  impression to the  purchaser;
  (viii)  Label  disclaimers which negate  or detract from labeling
statements required under the Act and these regulations;
                                         87

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   (ix)  Claims as to the safety of the pesticide or its ingredients,
 including statements such  as  "safe," "nonpoisonous," "noninjurious,"
 "harmless" or "nontoxic to humans and pets* with or without such
 a qualifying phrase as "when  used as directed"; and
   (x)  Non-numerical and/or comparative statements on the safety
 of the product, including  but not limited to:
   (A)  "Contains  all natural  ingredients";
   (B)  "Among the least toxic chemicals known"
   (C)  "Pollution approved"
   (6)  Final printed labeling,  (i)  Except as provided in
 paragraph (a)(6)(ii)  of this  section, final printed labeling must
 be submitted and  accepted  prior to registration.  However, final
 printed labeling  need not  be  submitted until draft label texts
 have  been provisionally accepted by the Agency.
   (ii)   Clearly legible reproductions or photo reductions will be
 accepted for unusual labels such as those silk-screened directly
 onco  glass or metal containers or large bag or drum labels.  Such
 reproductions must be of microfilm reproduction quality.
   (b)   Name, brand, or trademark.  (1)  The name, brand, or
 trademark under which the  pesticide product is sold shall appear
 on the  front panel of the  label.
   (2)   No name, brand, or  trademark may appear on the  label which:
   (i)   Is false or misleading, or
   (ii)   Has  not been approved by the Administrator  through
 registration or supplemental  registration as an additional  name
 pursuant to  $ 162.6(b)(4).
   (c)   Name  and address of producer, registrant, or person  for
 whom  produced.  An unqualified name and address given  on thj»
 label shall  be  considered  as  the name and address of the producer.
 If  the  registrant's name appears on the label  and  the  registrant
 is not  the producer,  or if the name of the person  for  whoa the
 pesticide was produced appears on the  label,  it must be qualified
 by appropriate  wording such as "Packed for ***,*  "Distributed by
 ***,"   or "Sold by •*•• to show that the  name  is  not  that of  the
 producer.
   (d)   Net weight or measure  of contents.   (1)  The net weight or
measure  of content shall be exclusive  of  wrappers or other
materials  and shall be the average content unless explicitly
 stated  as a  miniauai quantity.
   (2)   If the pesticide is a  liquid,  the  net content statement
shall be in  terms of liquid measure  at 68*P  (20*C) and shall be
expressed  in conventional  American units  of  fluid ounces, pints,
quarts,  and  gallons.       \
   (3)   If  the pesticide is solid  or  semisolid, viscous or
pressurized,  or is a mixture  of  liquid and solid, the  net content
statement  shall be in terms of weight  expressed as avoirdupois
pounds  and ounces.
   (4)   In  all cases,  net content  shall be stated in terms of the
largest  suitable  units, i.e... "1  pound 10 ounces*  rather than
"26 ounces."
                                       88

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    (5)  In addition  to  the required units specified,  net content
  nay be expressed  in metric units.
    (6)  Variation  above minimum content or around an  average  is
  permissible  only  to the extent that it represents deviation
  unavoidable  in  good manufacturing practice.  Variation below a
  stated minimum  is not  permitted.  In no case shall the average
  content of the  packages in a shipment fall below the stated
  average content.
    (e)   Product  registration number.  The registration number
  assigned to  the pesticide product at the time of registration
  shall  appear on the label, preceded by the phrase "EPA Registration
  No.,"  or the phrase "EPA Reg. No."  The registration number  shall
  be  set  in type  of a size and style similar to other print on that
  part  of the  label on which it appears and shall run parallel to
  it.   The  registration number and the required identifying phrase
  shall  not appear  in such a manner as to suggest or imply
  recommendation  or endorsement of the product by the Agency.
   (f)   Producing establishments registration number.  The producing
  establishment registration number preceded by the phrase "EPA
  Est.",  of the final establishment at which the product was produced
y  may appear in any suitable location on the label or immediate
  container.   It  must appear on the wrapper or outside container of
  the package  if  the  EPA establishment registration number on the
  immediate container cannot be clearly read through such wrapper
 or container.
   (g)   Ingredient statement-*(1)  General.  The label of each
 pesticide product must bear a statement which contains the name
 and percentage  by weight of each active ingredient, the total
 percentage by weight of all inert ingredients; and  if the pesticide
 contains arsenic in any form, a statement of the percentages.of
  total and water-soluble arsenic calculated as elemental arsenic.
 The active ingredients must be designated by the  term "active
 ingredients*  and the inert ingredients by  the term  "inert
 ingredients," or the singular forms of these terms  when appropriate.
 Both terms shall be in the same type size, be aligned to  the same
 margin and be equally prominent.  The statement  "Inert Ingredients,
 none" is not  required Cor pesticides which contain  100 percent
 active ingredient*.  Unless the ingredient statement  is a complete
 analysis of the pesticide, the terra "analysis"  shall  not  be used
 as a heading  for the ingredient statement.
   (2)   Position of  ingredient statement,   (i)   The  ingredient
 statement is  normally required on the front panel of  the  label.
 If there i« an outside conVainer or wrapper  through which the
 ingredient statement cannot be clearly  read,  the ingredient
 statement must also appear on such outside container or wrapper.
 If the size or font of the package makes  it  impracticable to place
 the  ingredient statement on the front panel  of  the label, permission
 may  be granted for  the ingredient statement  to  appear elsewhere.
   (ii)  The text of the ingredient statement «ust run parallel
 with other text on the panel on which  it  appears, and must be
 clearly distinguishable from and must  not be placed in the body
 of other text.
                                         89

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   (3)  Name* to be used in ingredient statement.  The name used
 foe each ingredient shall be the accepted common name, if there
 is one/ followed by the chemical name.  The common name may be
 used alone only if it is well known.  If no common name has been
 established/ the chemical name alone shall be used.  In no case
 will the use of a trademark or proprietary name be permitted unless
 such name has been accepted as a common name by the Administrator
 under the authority of Section 25(c)(6).
   (4)   Statements of percentages.   The percentages of ingredients
 shall  be stated in terms oC weight-to-weight.  The sum of per-
 centages of the active and the inert ingredients shall be 100.
 Percentages shall not be expressed  by a range of values such as
 "22-25%.*  If the uses of the pesticide product are expressed as
 weight of active ingredient per unit area/ a statement of the
 weight of active ingredient per unit volume of the pesticide
 formulation shall also appear in the ingredient statement.
   (5)   Accuracy of stated percentages.  The percentages' given
 shall  be as precise as possible reflecting good manufacturing
 practice.   If there may be unavoidable variation between manu-
 facturing batches/ the value stated for each active  ingredient
 shall  be  the lowest percentage which may be present.
   (6)   Deterioration.   Pesticides which change  in  chemical
 composition significantly must meet the following  labeling  re--
 quirements:
   (i)   In cases where  it is determined that a pesticide  formulation
 changes  chemical composition significantly/ the product  must  bear
 the following statement in a prominent position on the label:   "Not
 for sale  or use after  (date].*
   (ii)   The product must meet all label claims  up  to the expiration
 time indicated on the  label.
   (7)   Inert ingredients.  The Administrator may  require the'name
 of any  inert ingredient(s) to be listed  in  the  ingredient statement
 if he determines that  such ingredient(s) may pose  a hazard to man
 or the environment.
   (h)  Warnings and precautionary statements.   Required  warnings
 and precautionary statements concerning  the general areas of
 toxicological hazard including hazard  to  children/ environmental
 hazard/ and physical or chemical hazard  fall  into two groups; those
 required on the front'panel of the  labeling and those which may
appear elsewhere.   Specific requirements  concerning content/
placement/  type size/  and prominence are  given below.
  (1)  Required front  panel statements.   With the exception of  the
child hazard warning statement, the text  required on the front
panel of  the label is  determined by the  Toxicity Category  of the
pesticide.   The category is assigned on  the basis of the highest
hazard shown by any of the indicators in the table below:
                                      90

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Hazard Indicators

Oral lOjg
inhalation 1C
OanMl LO
Eya af facts
%
Skin affacts

I
Up to and
Including
90 «ag/kg
Up to and
Including
.2 «g/l Itar
Up to and
Including
200«g/kg
Corroslva;
cornoal opacity
not ravarslbla
•Ithln 7 days
Corrof lv«
Toatcltv c
II
Froa 30 thru
900 «g/kg
from .2 thru
2 ag/l Itar
Fro. 200
thru 2000
Cornaal opacity
ravarslbla
within 7 days;
Irritation
persisting for
7 days
Savara Irritation
at 72 tours
tatagorlas
III
from 900 thru
9000 «g/kg
-
Fro* 2 thru
20 ag/Mtar
from 2.000 thru
20.000
No cornaal opacity;
Irritation
ravarslbla
•Ithln 7 days
Mod«!°ata Irritation
at 72 heirs
•

IV
Graatar than
9000 «g/kg
Graatar than
20 •g/Mt«r
Graatar than
20.000
No Irritation
Mild or slight
Irritation at
*72 hours
   (i)  Human hazard signal word.--(A)  Toxicity Category I.   All
pesticide products m««ting th« crittria of Toxicity Category I
shall bear on  the front panel the signal word "Danger."  In
addition if the product was assigned to Toxieity Category I on
the basis of its ora^, inhalation or dermal toxicity (as distinct
from skin and eye local effects) the word "Poison* shall appear
in red on a background of distinctly contrasting color and the
skull and crossbones shall appear in immediate proximity to the
word "poison.*           \
  (B)  Toxicity Category  II.  All pesticide products meeting  the
criteria of Toxicity Category II shall bear on the front panel*
the signal word "Warning."
  (C)  Toxicity Category  III.  All pesticide products meeting  the
criteria of Toxicity Category III shall bear on the front panel-
the signal word "Caution.*
  (0)  Toxicity Category  IV."  All pesticide products meeting  the
criteria of Toxicity Category IV shall bear on the front panel
the signal word "Caution."
                                    91

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   (E)  Use) of signal words*   Use of any signal word(s) associated
 with a higner Toxicity category is not permitted except when the
 Agency determines that such  labeling  is necessary to prevent
 unreasonable adverse effects on man or the environment.  In no
 case shall more than one  human  hazard signal word appear on the
 front panel of a label.
   (ii)   Child hazard warning.   Every  pesticide product label shall
 bear on the front panel  the  statement "keep out of reach of
 children."  Only in  cases where the likelihood of contact with
 children during distribution, marketing,  storage or use is
 demonstrated by the  applicant to be extremely remote, or if the
 nature  of the pesticide  is such that  it is approved for use on
 infants or small children, may  the Administrator waive this
 requirement.
   (iii)  Statement of practical treatment—(A)  Toxicity
 Category I.   A statement  of  practical treatment (first aid or
 other)  shall appear  on the front panel of the label of all
 pesticides falling into Toxicity Category I on the basis of oral,
 inhalation or dermal toxicity.  The Agency may, however, permit
 reasonable variations in  the placement of the statement of
 practical  treatment  is some  reference such as "See statement of
 practical  treatment  on back  panel" appears on the  front panel
 near  the -word "Poison" and the  skull  and  crossbones.
   (B)   Other toxicity categories.  The statement of practical
 treatment  is not required on the front panel except as described
 in paragraph (h)(1)(iii)(A)  of  this section.  The  applicant may,
 however,  include  such a front panel statement at hit option.
 Statements of practical  treatment are, however, required elsewhere
on the  label  in  accord with  paragraph (h)(2) of this section  if
 they do not  appear on the front panel.
   (iv)  Placement  and prominence.  All the required front  partel
warning statements shall  be  grouped together on the  label, and
shall appear with  sufficient prominence relative to other  front
panel text and graphic material to make them unlikely  to  be  over-
looked under  customary conditions of  purchase and  use.  The
following  table  shows the minimum type size  requirements  for the
front panel  warning  statements  on various sizes of labels:
V
Size of label front panel
in square inches


Above 10 to 15 	
Above IS to 30 	
Over 30 .... % 	
Points
Required
signal word,
all capitals
6
10
12
14
18
"Keep out
of reach of
Children"
6
6
8"
10
12
                                       92

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     (2)   Other required warnings  and precautionary statements.   The
  warnings and precautionary statements  as required below shall  appear
  together on  the  label under the general  heading "Precautionary
  Statements"  and  under appropriate subheadings  of "Hazard to  Humans
  and Domestic Animals/" "Environmental  Hazard"  and "Physical  or
  Chemical Hazard."
    (i)   Hazard to humans and domestic animals.   (A)  Where a  hazard
  exists  to humans or domestic animals,  precautionary statements
  are required indicating the particular hazard, the route(s)  of
  exposure and the precautions to be taken to avoid accident/  injury
  or damage.   The precautionary paragraph  shall  be immediately
  preceded by  the appropriate hazard signal word.
    (B)   The following table depicts typical precautionary statements.
  These statements must be modified or expanded  to reflect specific
  hazards.
Tdxlclty
category
                          Precautionary statements by toxic I ty category
  Oral. Inhalation, or dermal to*lell>
                            Skin and eye local effects
  I
 it
III
 IV
Fatal (poisonous)  If svalloved (Inhaled or
 absorbed through  skin).  Do not breathe
 vapor Idust| or spray mistI.  Do not gat
 In eyes, on skin, or on clothing (Front
 panel statement of practical treatment
 reau'red.I.


May be fata' If s»ofloved I Innate* or
 abso-bed through  the sklnl.  Oo not breathe
 vapors (dust or spray mlstl.  Oo not get In
 eyes, on skin, or o* clothing. (Appropriate
 first aid statements required.I.
Harmful  I f tval fOMd I fnmtlad or abaorbed
 through the skin).  Avoid breothlng vapors
 .(dust or spr«y elstt.  Avoid contact with
 sk'n leyee or cletftlmfI. IAppropriate
 first aid stitsmantVequlred.l.
(NO
statements required.!,
                      Corrosive, causes eye and sktn da*ago lor
                       skin IrrltatlonI*  Oo not get In efes, on
                       skin, or on cloth'ng. Wear goggles or face
                       shield and rubber gloves when handling.
                       Hansfut or fatal If svalloved.
                      (Appropriate first aid statement required.)
                                              •
                      Causes eye land sktnl Irritation. Oo not
                       got la eyes, on skin, or on clothing.
                       Harmful If Ma Moved.  (Appropriate first
                       aid statement required.!.
                      Avoid contact vltti skin, eyes or clothing.
                       In caso of contact Immediately flush
                       eyes or skin v'th plenty of water.  Gat
                       medical attention If Irritation persists.
(No precautionary statements required.!.    |
   (ii)   Environmental  hazards.   Where a hazard  exists to  non-
target  organisms  excluding  humans and domestic  animals, precautionary
statements  are  required stating  the  nature of the hazard  and the
appropriate precautions to  avoid potential accident, injury or
                                                  93

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 damage.  Examples of the hazard  statements and the circumstances
 under which they are required  follow:
   (A)  If a pesticide intended for outdoor use contains an active
 ingredient with a mammalian acute oral LOso of 100 or less, the
 statement "This Pesticide  is Toxic to Wildlife* is required.
   (B)  if a pesticide intended for outdoor use contains an active
 ingredient with a fish  acute LCso of 1 ppm or less, the statement
 "This Pesticide is Toxic to Fish" is required.
   (C)  If a pesticide intended for outdoor use contains an active
 ingredient with an avian acute oral LOso °* 10° mg/kg or less, or
 a  subacute dietary LCso of 500 ppm or less, the statement "This
 Pesticide is Toxic to Wildlife*  is required.
   (D)  If either accident  history or field studies demonstrate
 that  use  of  the pesticide may  result in fatality to birds, fish
 or mammals,  the statement  "This  pesticide is extremely  toxic  to
 wildlife  (fish)*  is  required.
   (E)   For uses involving  foliar application to agricultural
 crops,  forests,  or shade trees,  or for mosquito abatement
 treatments,  pesticides  toxic to  pollinating insects must bear
 appropriate  label  cautions.
   (F)   For  all  outdoor  uses other than aquatic applications  the
 label must bear  the  caution "Keep out of lakes, ponds or streams.
 Do not  contaminate water by cleaning of equipment  or disposal of
wastes.*
   (iii)   Physical  or  chemical  hazards.  Warning statements on the
 flamenability or explosive characteristics of the pesticide are
 required  as  follows:
Masn point
(A) MCSSUNI2EO
'las* point at or bale* 20*P} If tuere !• •
flaSftbOCk at any «Olve OpMlng.
1
II
Hash point above 20*T «* flfe ever IO*F or If
rn« f l OM e*teM Ion Is MTO tHM.lt In. long
at • tfisteeae e» ft In. *rm t*e HMO.
.

CD NONM.CSSUII;



ftMulred tvvt
CONTAINCRS
CxtroMly flMMOle. Content* un««r pressure.
Keep e*ov fro» flro, sporiu, «nd n««t«4
turf KM. Oo not punetur* or Inelnorat*
eonttlnor* hooMiro to toaporaturM tbo»«
I30*F MY CMM bursting.
FlMMblo. Contoats wnoar prossura. Kaop a«ay
from noat, sparks, a** opon Mama. Oo not
punctvro or Inclnorata cental nor. bpotura to
taav«r«tvrM abovo 130*F MT eawsa bursting.
Contacts unoor prat sura. Oo not uso or ttora
naar no«t or opon flaao. Oo not pvnetur* or
Inelnorato cental nor* Cxposura to ta«para-
turas aoovo 130*f My causa bursting.
ECO CONTAINCMS
Cxtraaaly flaaMbla. Kaoe «••¥ fro* f Ira,

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    (i)   Direction* for Use—(1)  General  requirementa—(i)  Adequacy
  and clarity ot directions.  Directions Cor use muse be stated in
  terns whicn can be easily read and understood by  the average
  person  likely to use or to supervise the use of the pesticide.
  When followed, directions oust be adequate to protect the public
  from fraud and from personal injury and  to prevent unreasonable
  adverse effects on the environment.
    (ii)  Placement of directions for use.  Directions may appear
  on any portion of the label provided that they are conspicuous
  enough to be easily read by the user of  the pesticide product.
  Directions for use may appear on printed or graphic matter which
  accompanies the pesticide provided that:
   (A)   If required by the Agency, such printed or graphic matter
  is securely attached to each package of  the pesticide, or placed
 within the outside wrapper or bag;
   (B)   The label bears a reference to the directions  for use  in
 accompanying leaflets or circulars, such as "See  directions in
 the enclosed circular."  and
   (C)   The Administrator determines that it is not necessary  for
 such directions to appear on the label.
   (iii)   Exceptions to requirement for direction  for  use—(A)
 Detailed directions for use may be omitted from  labeling of
 pesticides which are intended for use only by manufacturers of-
 products other than pesticide products in their  regular manu-
 facturing processes, provided that:
   U)   The label clearly shows that the  product  is  intended  for
 use"~only in manufacturing processes and  specifies the type(s) of
 products involved.
   (2)   Adequate  information such as technical data  sheets  or
 bulletins, is  available to the trade specifying  the  type  of
 product  involved and its proper use in manufacturing  processes;
   (2)   The product will not come into the hands  of  the general
 public except  after incorporation into finished  products;  and
   (j4)  The Administrator determines that such directions are  not
 necessary to prevent unreasonable adverse effects on  man or the
 environment.
   (B)  Detailed  directions for use may be omitted from the labeling
 of  pesticide products Cor which sale is limited to physicians,
 veterinarians* or druggists, provided that:
   U)  The) label clearly states that the product is for use only
 by physicians  or veterinarians;
   (2)  The) Administrator determines that such directions are not
 necessary to prevent unreasonable adverse effects on man or  the
environment; and
   (2>  The product  is also a drug and regulated under the provisions
of The Federal  Food, Drug and Cosmetic Act.
   (C)  Detailed  directions for use may be omitted from the labeling
of pesticide products which are intended  for use only by fqrmulators
 in preparing pesticides for sale to the public,  provided that:
   (1)  There is  information readily available to the formulators
on the composition,  toxicity, methods of  use, applicable restrictions
or limitations,  and effectiveness of  the  product for pesticide
purposes;


                                       95

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    (£)  Tte label clearly states  that  the product is intended for
 use~"only in manufacturing,  formulating, mixing, or repacking for
 use as a pesticide and specifies  the  type(a) of pesticide products
 involved;
    (2)  The product as finally  manufactured, formulated, mixed, or
 repackaged is registered; and
    (_4)  The Administrator determines that such directions are not
 necessary to prevent unreasonable adverse effects on man or the
 environment.
    (2)  Contents of Directions  for Use.  The directions for use
 shall include the following, under the headings "Directions for
 Use":
   (i)  The statement of use classification as prescribed in
 162.10(j) immediately under the  heading "Directions for Use."
   (ii)   Immediately below the  statement of use classification,
 the statement "It is a violation  of Federal law to use this
 product in a  manner inconsistent  with its labeling."
   (iii)  The  site(s) of application,  as for example the crops,
 animals,  areas,  or objects  to  be  treated.
   (iv)   The target pest(s) associated with each site.
   (v)   The dosage rate associated with each site and pest.
   (vi)   The method of application, including  instructions  for
 dilution*, if  required, and  type(s) of application apparatus or*
 equipment requried.
   (vii)   The  frequency and  timing of  applications necessary to
 obtain  effective results without causing unreasonable  adverse
 effects on the environment.
   (viii)   Specific limitations on reentry  to  areas where  tht
 pesticide has been applied, meeting the  requirements concerning
 reentry provided by 40 CPR Part  170.
   (ix)   Specific direction* concerning  the  storage and disposal
 ol!  the  pesticide and its container, meeting  the  requirements  of
 40  CPR  Part 165.  These instructions  shall  be grouped  and appear
 under the heading "Storage and Disposal."   This  heading must  be
 set in  type of  the S«JM minimum  sizes as  required for  the child
 hazard  warning  (See Table in $ 162.10(h)(1)(iv).)
   (x)   Any limitations or restrictions  on  use required to prevent
 unreasonable  adverse effects,  such as:
   (A)   Required  internals between application and harvest of  food
 or  feed crops.
   (B)   Rotational crop restrictions.
   (C)   Warnings  as required against use on certain crops, animals,
 objects,  or in or adjacent\to  certain areas.
   (D)   [Reserved]
   (E)   Por  restricted use pesticides, a statement that the
 pesticide may be applied under the direct supervision of  a
 certified applicator who is not  physically present at the site  of.
 application but  nonetheless available to the person applying the
 pesticide,  unless the Agency -has determined that the pesticide
may only  be applied under the  direct supervision of a ctrtifisd
 applicator  who is physically present.
                                           96

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    (P)  Other pertinent information  which  the  Administrator
 determines to be necessary for the  protection of man and the
 environment.
    (j)  Statement of Use Classification.   By October 22, 1976, all
 pesticide products must bear on their  labels  a  statement of use
 classification as described in paragraphs  (j)(l) and (2) of this
 section.  Any pesticide product for which some  uses are classified
 for general use and others for restricted  use shall be separately
 labeled according to the labeling standards set forth in this
 subsection, and shall be marketed as separate products with
 different registration numbers, one bearing directions only for
 general use(s) and the other bearing directions for restricted
 use(s)  except that, if a product has both restricted use(s) and
 general use(s), both of these uses  may appear on a product labeled
 for restricted use.  Such products  shall  be subject to the
 provisions of $ 162.10(j)(2).
   (1)   General Use Classification.   Pesticide products'bearing
 directions for use(s)  classified general  shall  be  labeled with
 the exact words "General Classification"  immediately below the
 heading "Directions for Use."  And  reference  to the general
 classification that suggests  or implies that  the general utility
 of  the  pesticide extends beyond those  purposes  and uses contained
 in  the  Directions for Use  will be considered  a  false or misleading
 statement under the statutory definitions of  misbranding.
  (2)   Restricted Use  Classification.  Pesticide products bearing
 direction for use(s)  classified restricted shall bear  statements
 of  restricted use classification on the front panel as described
 below:
  (i)   Front  panel statement of restricted use  classification.
 (A)  At the  top of the front panel  of  the label, set  in  type  of
 the  same  minimum sizes as  required  for human  hazard signal  words
 (see table  in S 162.10(h)(1)(iv)),  and appearing with  sufficient
 prominence  relative to other text and  graphic material on  the
 front panel  to make it unlikely to  be  overlooked under customary
 conditions of  purchase and use, the statement "Restricted  Use
 Pesticide" shall appear*
  (B)   Directly below this statement on the  front  panel,  a summary
 statement of  the terms of  restriction  imposed as  a precondition
 to registration shall*appear.  If use  is  restricted to certified
applicators*  the following statement is  required!   "For retail
sale to and use  only by Certified Applicators or  persons under
 their direct  supervision and only  for  those  uses  covered by the
Certified Applicator's certification."  if,  however,  other
regulatory restrictions are imposed, the  Administrator will define
the  appropriate  wording Cor the terras  of  restriction by regulation
  (k)  Advertising.   [Reserved]

                                                           *
 (40  PR 28268,  July 3,  1975; 44 PR  32329,  Aug.  I,  1975; 40 PR
38S71, Aug. 21,  1975,  as amended at 43 PR 5786, Feb. 9, 1978]
                                      97

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Criteria
                           PHYS/CHEM-1

                    PHYSICAL/CHEMICAL HAZARDS

                                     Required Label Statement
I.   Pressurized  Containers

    A.   Flashpoint  at  or  below
        20°F;  or if there is  a
        flashback at any  valve
        .opening.
    B.   Flashpoint  above  20°F
        and  not  over  80°F;  or
        if the  flame  extension
        is more  than  18 inches
        long  at  a distance  of
        6 inches from the
        valve opening.

    C.   All Other Pressurized
        Containers~~
II.   Non-Pressurized Containers

    A.  Flashpoint at or below
        20°F.
    B.   Flashpoint above 20°F
        and noc over 80°F.

    C.   Flashpoint over 80°F
        and noc over 150°F.

    D.   Flashpoint above
        150°F.
                                      Extremely flammable.
                                      Contents  under  pressure.
                                      Keep away from  fire,  sparks,
                                      and heated surfaces.   Do  not
                                      puncture  or incinerate
                                      container.  Exposure  to
                                      temperatures above 130°F
                                      may cause bursting.

                                      Flammable.  Contents  under
                                      pressure.  Keep* away  from
                                      heat, sparks, and flames   Do
                                      not puncture or incinerate
                                      container.  Exposure  to
                                      temperatures above 130°F
                                      may cause bursting.

                                      Contents  under pressure.
                                      Do not use or store near
                                      heat or open flame.   Do not
                                      puncture  or incinerate
                                      container.  Exposure to
                                      temperatures above 130°F
                                      may cause bursting.
                                      Extremely flammable.  Keep
                                      away from fire, sparks, and
                                      heated surfaces.

                                      Flammable.  Keep away from
                                      heat and open flame.

                                      Do not use or store near
                                      heat and open flame.

                                      None required.
                                    98

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                            STOR-1

             STORAGE INSTRUCTIONS FOR PESTICIDES

 Heading;

 All  products are required co bear specific label  instructions
 about  storage and disposal.  Storage and disposal  instructions
 must be grouped together in the directions for use portion  of
 the  label under the heading STORAGE AND DISPOSAL.   Products
 intended solely for domestic use need not include  the heading
 "STORAGE AND DISPOSAL."

 Storage Instructions:

 All  product labels are required to have appropriate storage
 instructions.  Specific storage instructions are  not prescribed.
 Each registrant must develop his own storage instructions,
 considering, when applicable, the following factors: '

 1.   Conditions of storage that might alter the composition or
     usefulness of the pesticide.  Examples could  be temperature
     extremes, excessive moisture or humidity, heat, sunlight,
     friction, or contaminating substances or media.

 2.   Physical requirements of storage which might adversely
     affect the container of the product and its ability to
     continue to function properly.  Requirements might include
     positioning of the container in storage, storage or damage
     due to stacking, penetration of moisture, and ability  to
     withstand shock or friction.

 3.   Specifications for handling the pesticide container,
     including movement of container within the storage area,
     proper opening and closing procedures (particularly for
     opened containers), and measures to minimize exposure
     while opening or closing container.

4.   Instructions on what to do if the container Is damaged in
     any way, or if the pesticide is leaking or has been
     spilled, and precautions to minimize  exposure  if damage occurs

5.   General precautions concerning  locked storage,  storage in
    original container only, and separation of pesticides
     during storage to prevent cross-contamination of  other
     pesticides, fertilizer, food, and  feed.

6.   General storage instructions for household products  should
     emphasize storage in original container  and placement  in
     locked storage areas.
                                     99

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                                PEST/DIS-1

             PESTICIDE DISPOSAL INSTRUCTIONS

 The label  of all produces, except chose intended solely for domestic
 use, muse  bear explicit instructions about pesticide disposal.  The
 statements listed below contain the exact wording that must appear on
 the label  of these products:

 1.   The labels of all products, except domestic use, must contain the
 statement,  "Do not contaminate water, food, or feed by storage  or disposal."

 2.   Except those products intended solely for domestic use, the labels
 of  all  products that contain active ingredients that are Acute  Hazardous
 Wastes  or  are assigned to Toxicity Category I on the basis of oral or
 dermal  toxicity, or Toxicity Category I or II on the basis of acute
 inhalation toxicity must bear the following pesticide disposal  statement:

     "Pesticide wastes are acutely hazardous.  Improper disposal of
    excess  pesticide, spray mixture, or rinsate is a violation  of Federal
    Law.   If these wastes cannot be disposed of by use according to
    label  instructions, contact your State Pesticide or Environmental
    Control Agency, or the Hazardous Waste representative at  the nearest'
    EPA Regional Office for guidance."

 3.  The labels of all products, except those intended for domestic use,
 containing  active or inert ingredients that are Toxic Hazardous Wastes
 or meet any of the criteria in 40 CFR 261, Subpart C for a hazardous
 waste must bear the following pesticide disposal statement:

    "Pesticide wastes are toxic.  Improper disposal of excess pesticide,
    spray mixture, or rinsate is a violation of Federal Law.   If these
    wastes cannot be disposed of by use according to label instructions,
    contact your State Pesticide or Ehvironmental Control Agency, or the
    Hazardous Waste representative at the nearest EPA Regional Office
    for guidance."

4.  Labels  for all other products, except  those  intended  for domestic
use, must bear the following pesticide disposal statement:

    "Waste* resulting from the use of this product may be disposed of  on
    site or at an approved waste disposal  facility."

 5.  Products intended for domestic use only must bear the following
disposal statement:  "Securely wrap original  container in several layers
of newspaper and discard in trash."
                                        100

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                          CONT/DIS-1

               'CONTAINER DISPOSAL  INSTRUCTIONS

    The label of each produce  muse bear container disposal
instructions appropriate to  the  type of container.

    1.  Domestic use products  must bear one of the following
container disposal statements:
Container Type
                Statement
Non-aerosol products
(bottles, cans, iars)
Non-aerosol products
(bags)
Aerosol products
Do not reuse container (bottle, can, jar).
Rinse thoroughly before discarding in trash.
Do not reuse bag. Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or puncture.
    2.  All other products  must  bear-container disposal instructions,
based on container type,  listed  below:
 Container Type
                 Statement
 Metal
 containers
 (non-aerosol)
Triple rinse (or equivalent).   Then offer
for recycling or reconditioning,  or puncture
and dispose of in a sanitary landfill,  or  by
other procedures approved by state and  local
authorities.
 Plastic containers
Triple rinse (or equivalent).Then offer
for recycling or reconditioning,  or puncture
and dispose of in a sanitary landfill,  or
incineration, or, if allowed by state and
local authorities, by burning.  If burned,
stay out of smoke.	
 Glass containers
Triple rinse (or equivalent).  Then dispose
of in a sanitary landfill or by other
approved state and local procedures.	
 Fiber drums
 with liners
Completely empty liner by shaking and
capping sides and bottom to loosen clinging
particles.  Empty residue into application
equipment.  Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reused1. dispose of in the same manner.
 Paper and
 plastic bags
Completely empty bag into application
equipment.  Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning.  If burned, stay
out of smoke.             	
 Compressed  gas
 cylinders
Return empty cylinder  for reuse  (or
similar wording)               -	
 ]J  Manufacturer may replace this phrase with one indicating
 "   whether and how fiber drum may be reused.
                                    101

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APPENDIX  III



 USE INDEX
- 101-A -

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             EPA Compendium of Acceptable Uses

           ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

                     TABLE OF CONTENTS

S,ite Name                                                  Pane

TERRESTRIAL FOOD CROP                                        3
   (Agricultural Crops)                                       3
TERRESTRIAL NONFOOD CROP                                    16
   (Agricultural Crops)                                      16
   (Ornamental Plants and Forest Trees)                      1-7

  Ageratum                                                  17
  Alfalfa                                                    3
  Alfalfa (seed crop)                                        5
  Alfalfa-Grass Mixture                                      6
  Alyssum                                                   17
  Arborvitae                                                17
  Aster                                                     Id
  Astilbe                                           .        18
  Azalea                                                    17
  Balsam Fir                                                17
  Barberry                                                  17
  Beans (lima,  snap)                                         6
  Begonia                                                   17
  Birch                                                     17
  Blackberry                                                 6
  Bluebell                                                  18
  Blueberry                                                  6
  Boxwood                                                   17
  Camellia                                                  17
  Carnation                                                 18
  Carrots                                                    7
  Cedar                                                     17
  Cherry (ornamental)                                       17
  Chrysanthemum                                             17
  Clover                                                     7
  Coleus                                                    17
  Columbine                                                 18
  Coral Bel1m                                               18
  Cotoneaster                                               17
  Crabapple (ornamental)                                     17
  Cranberry                                                  7
  Creeping Juniper    '                                       18
  Daffodil* (bulbs)                                          18
  Dahlias (bulbs)                                            18
  Dianthus                                                   17
  Dogwood                                                    17
  Dutch Iris (bulbs)                                         18
  Easter Lilies                                              19
  English Ivy                                                1Q
  Enkianthus                                                 17
  Euonymus                                                   17
  Fir                                                        17
  Forget-Me-Not                                              IS
  Forsythia                                                  17

Issuedi  10-15-86       I-O183O1-1
Provisional Updates   11-1O-87
                                 102

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             EPA Compendium of  Acceptable Use*

           ISOPROPYL N-(3-CHLOROPHENYL)CARSAMATE

                     TABLE OF CONTENTS

Site Name	Page

  Fuchsia                                                  17
  Garden Balsam                                            17
  Garlic                                                    S
  Geranium                                                 17
  Ginkgo                                                   19
  Gladiolus (bulbs)                                         IB
  Grasses,  Perennial (seed crop)                             9
  Heather                                                  17
  Hemlock                                                  17
  Holly                                                    17
  Honeysuckle                                              17
  Hydrangea                                                17
  Iris                                                     19
  Juniper                                                  17
  Ladino Clover                                             9
  Larkspur                                                 IB
  Laurel                                                   17
  Leucothoe                                                17
  Ligustrum                                                17
  Lilac                                                    17
  Lilies (bulbs)                                           19
  Locust                                                   17
  Magnolia                                                 17
  Mahonia                                                   IB
  Maple                                                    IB
  Marigold                                                  17
  Mock-Orange                                               IB
  Myrtle                                                    IS
  Narcissus (bulbs)                                          19
  Onion                                                      9
  Ornamental Woody Plants                                  20
  Pachysandra                                               IS
  Pansies                                                   17
  Peonies                                                   18
  Petunias                                                  17
  Pieris                                                    IB
  Pine                                                      IB
  Plum (ornamental)                                          IB
  Poplar                                                    IS
  Potato                                                    10
  Raspberry                                                  6
  Red Clover                                                 3
  Rhododendron                                              IS
  Rose                                                      IS
  Safflower                                                 12
  Salvia                                                    17
  Snapdragon                                                17
  Southern Peas                                             12
  Soybeans                                                  1£
  Spinach (fall seeded)                                     14

Issued I  10-15-86       I-O18301-ii


                                103

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             EPA Compendium of Acceptable Uses

           ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

                     TABLE OF CONTENTS

Site Name                                                  Page

  Spirea                                                    IB
  Spruce                                                    18
  Sugar Beets                                               14
  Sugar Beets (seed crop)                                   15
  Sycamore                                                  18
  Tobacco, Flue-Cured                                       16
  Tomato                                                    IS
  Trefoil                                                    9
  Tulips  (bulbs)                                            19
  Viburnum                                                  18
  White Clover                                               9
  Wintercreeper                                             18
  Yew                                                       18
  Zinnia                                                    17
Issued!  10-15-86       X-018301-1n

                         •     104

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                       EPA Compendium of Acceptable Uses

hO18301             ISOPROPYL N-(3-CHLOROPHENYL)CARBAM«TE»

          TYPE PESTICIDES  Herbicide, PlantxRegulator

          FORMULATIONS;
          Tech OB*)
          G    (5*,  10.3%,  20*)
          EC   (1 Ib/gal "or 11.9* a. i. ,  1.33 Ib/gal or 15* a. i. ,  2 Ib/gal or
               ££. £* a. i.,  £5%,  3 Ib/gal or 36% a. i.,  4 Ib/gal or 47% a. i. )
          RTU  (4 Ib/gal or 46% a. i.  or 46.5* a. i. , 4.3 Ib/gal or 49.65*
               a. i., 7 Ib/gal or 78.4* a. i. or 78.5* a. i.)

          GENERAL WARNINGS AND LIMITATIONS;  A selective herbicide and plant
          regulator for use in agricultural and ornamental crops.  This chemi-
          cal is toxic to fish.   Do not apply directly to water or wetlands
          (swamps,  bogs,  marshes or potholes).   Do not apply where runoff is
          likely to occur.   Do not  contaminate water by cleaning of equipment
          or disposal  of wastes.  Adequate soil moisture  (rainfall or irriga-
          tion)  is necessary for effective weed control.  Do not cultivate or
          disturb soil after treatment.   For band and strip treatments,  re-
          duce dosages and water dilution rates proportionately.
          Interim Tolerances:  While petitions for tolerances for negligible
                                       1 action is completed,  interim toler-

                                       (other than those  listed  in the text)s
residues are pending and until «
ances are established.
Agricultural Crop Tolerances (o1
Rice, grain 0. 1
Livestock Tolerances:
Cattle, fat
Cattle, meat
Cattle, mbyp
Eggs
Goats, fat
Goats, meat
Goats, mbyp
Hogs, fat
Hogs, meat
Hogs, mbyp
Horses, fat
Horses, meat
Horses, mbyp
Milk
Poultry, fat
Poultry, meat
Sheep, fat
Sheep, m««t
Sheep, mbyp
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0. OS
0.05
0.05
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
(I)
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
ppm
         TIME  REQUIRED FOR CONTROL;  Not located.

         PHYTOTOXICITY TO TARGET WEEDS;  Not located.

         PHYTDTOXICITY TO CROPS:  Not located.



         *chlorpropham

         Issued!   10-15-86       1-018301-1
         Provisional  Updatei   11-10-87
                                       105

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                        EPA Compendium  of  Acceptable Uses

                      ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

           MODE OF ACTIONi   Suppresses  transpiration and respiration, inhibits
           root and epicotyl growth.
           BROADLEAF WEEDS CONTROLLED;

 PBKAIAA     Bittercress
 PEWAIBE     Black nightshade
 PADABBA     Carpetweed
 PAZAAAC     Chickweed
 PBGADAA     Dodder
 PBKAGAA     Falseflax
 PCOAFBA     Henbit
 PBTABAA     Horsetail
 PEAAGAC     Knotweed
 PEAA6BP     Ladysthumb
 PBKBDBB     London rocket                          (a)
 PCYAEAA     Loosestrife
 PDAAHAA .    Mallow
 PEAAGBO     Pennsylvania  smartweed
 PAAP.P.BP     Purslane
 PEAAHBB     Red sorrel
 PAFACBI      Redroot  pigweed
 PBKfiHBft     Sheperdspurse                          (a)
 PBKBCBft     Si bara
 PQPAAAV     Summer annual  weeds
 PEAAGAE     Tearthumb
 PEAAGBH     Wild  buckwheat
 PBKBKBB     Wild  mustard                           (a)
 PAAAAAW     Winter annual  weeds

              (a)   Controls  weeds when  treatment  is made in conjunction with
                    irrigation.
          GRASSES AND OTHER MONOCOTS  CONTROLLED;

PCACKBA     Annual bluegrass
PZAAAAD     Annual brome
PCAAAAB     Annual grasses
PCABHBB     Barnyardgrass
PCAADAA     Bentgrass
PCAAVBA     Bluejoint reedgrass
PCACHBB     Canarygrass
PCABRBA     Common velvet grass
PCABFAA     Crabgrass
PCAATBM     Downy brome
PCACUAA     Foxtail
PCAAAAF     Grain (volunteer)
PCABZBA     Italian ryegrass
PCABSBF     Little barley
PCACLBB     Rabbit foot polypogon
PCAEABE     Rattail fescue
          Issued:  10-15-86
I-O18301-£
                                      106

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PCLABAA
PCABKBC
PZAAAFX
PCAAOBB
PCAAAAM
PCACEBC
             EPA Compendium of Acceptable Uses

           ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

GRASSES AND OTHER MQNOCOTS CONTROLLED (continued)

  Rush
  St inkgrass
  Turkeyfoot grass
  Wild oats
  Winter annual grasses
  Witchgrass
          PLANT REGULATOR CLAIMS;

PZZZZZA     Plant regulator (fruit inhibitor)
PZZZZZA     Plant regulator (prevent sucker development)
PZZZZZA     Plant regulator (flower bud abscission)
PZZZZZA     Plant regulator (sprout inhibitor).
          Site. Dosaoe and
          Formulat ion
          (Ib a. i. /A)

          TERRESTRIAL FOOD CROP

            (Agricultural Crops)

/23001AA    Alfalfa
                         Tolerance.  Use.  Limitations
              (20% 3)
                         SO (I)  ppm (alfalfa)
                         50 (I)  ppm (alfalfa, hay)
                         2O day preharvest interval.
                         Do not graze or feed treated crop within
                         4O days of application.
                         Genera1 Informat i on 8  These uses will not
                         control attached dodder.  Use on alfalfa
                         planted no later than the spring or fall
                         of the previous year.  Do not apply to
                         alfalfa foliage that is wet or damp.
                         Seedling crops should have at least 4-true
                         leaves.  Do not use on grass-legume mixed
                         stands as grass may be injured.  Apply
                         when soil is moist.

                         Postemergence.  Broadcast.  Apply to  late
                         summer seeded or established alfalfa
                         plantings.
          Issuedi   10-15-66
                        1-018301-3
                                      107

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             EPA Compendium of Acceptable Uses

           ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE
Site. Dosage and
Formulation
(Ib a. i. /A)

  Alfalfa  (continued)

    4-6
    (4 Ib/gal EC)
    1-3
    (4 Ib/gal EC)
    2-4
    (4 Ib/gal EC)
    4-6
    <20X G)
    CSLN3
    4-6
    <2O* 6)
    CSLND
    2-3
    (4 Ib/gal EC)
 Tolerance. Use. Limitations
Issuedi  1O-13-86
 Postemergence.  Broadcast or  band.  For
 control  of dodder.  Apply in  20 or more
 gallons  of water  per  acre by  ground or 3
 or  more  gallons of water per  acre by air
 prior  to dodder germination.   Apply to the
 first  crop in  the early spring prior to
 alfalfa  breaking  dormancy or  at lay-by.
 Apply  to the second crop in early spring
 prior  to alfalfa  breaking dormancy and/or
 after  removal  of  first forage crop.
 Tank mix with  carbaryl.

 Use limited to areas  east of  the  Rocky
 Mountains.  Postemergence.  Broadcast or
 band.  For control of chickweed and downy
 brome.   Apply  in  20 to 40 gallons of water
 per acre to late  summer seeded or
 established alfalfa plantings.  Use the
 lower  dosage  from October through January
 and the  higher dosage after February  1.
 May be applied to actively  growing
 semi—dormant  or dormant alfalfa.

 Use limited to areas  west of  the  Rocky
 Mountains.  Postemergence.  Broadcast  or
 band.  Apply  in 20  to 40  gallons  of water
 per acre to summer  seeded or  established
 alfalfa  plantings.

 Use limited to CA,  ID,  NV,  OR, UT and  WA.
 Postemergence. Broadcast or  band.   For
 control  of dodder.   Apply in  the spring
 prior  to dodder germination.   Use the
 lower  dosage  for  repeat  applications and
 the higher dosage for single  applications.

 SLN -  Use limited to CA and UT.
 Postemergence. Broadcast or band.   For
 control  of  dodder.   Apply by ground or by
 air prior to  dodder germination.   Repeat
 application  in 4  to 6 weeks.

 SLN -  Use limited to Yuma County, AZ.
 Postemergence.  Broadcast.   Apply into the
 irrigation  water  system in the late fall
 or winter when alfalfa plants have at
 least  6-true  leaves and are 4 to 6 inches
 tall.

1-018301-4
                              108

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                       EPA Compendium of Acceptable  Uses

                     ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE
/23001BA
Site. Dosaoe and
Formulation
(Ib a. i. /A)

  A1 fa1 fa  (seed crop)
              4-6
              (4 Ib/gal EC)
              4-6
              (20X G)
              CSLN3
              4-6
              (20% G)
                                   Tolerance.  Use.  Limitations
20 (I) ppm (alfalfa)
50 (I) ppm (alfalfa,  hay)
£0 day preharvest interval.
Do not graze or feed treated crop within
40 days of application.
General Information;  These uses will not
control attached dodder.   Use on alfalfa
planted no later than the spring or fall
of the previous year.  Do not apply to
alfalfa foliage that is wet or damp.  Seed-
ling crops should have at least 4-true
leaves.  Do. not use on grass-legume mixed
stands as grass may be injured.
                           •»
Postemergence.  Broadcast or band.  For
control of dodder.  Apply in 20 or  more
gallons of water per acre by ground or 5
or more gallons of water per acre by air
prior to dodder germination.  Apply to the
first crop in the early spring prior to
alfalfa breaking dormancy or at  lay-by.
Apply to the second crop in early spring
prior to alfalfa breaking dormancy  and/or
after removal of first forage crop.
Tank mix with carbaryl.

Use limited to CAt  ID, NV,  OR, UT,  and  WA.
Postemergence.  Broadcast or band.   For
control of dodder.   Apply  in the spring
prior to dodder germination.  Use the  low-
•r dosage for repeat applications and  the
higher dosage for single applications.

SLN - Use limited to CA and UT.
Postemergence.  Broadcast  or band.   For
control of dodder.   Apply  by ground or by
air prior to  dgdder  germination.   Repeat
application  in 4  to  6  weeks.
          Issuedi   10-15-86
                         1-018301-5
                                       109

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                        EPA  Compendium of Acceptable Uses

                      ISOPROPYL N-(3-CHLORQPHENYL)CARBAMATE
 /28069AA
Site.  Dosage and
Formulation
(Ib a. i. /A)

  Alfalfa-Grass Mixture
               CSLND
               2-3
               (4 Ib/gal EC)
/15027AA
/O1002AA
/010060ft
/O1009AA
  Beans (lima,  snap)
              A
              (20* 6)
              (4  Ib/gal EC)
  Blackberry
  Raspberry

    6
    (20* G)
    (4 Ib/gal  EC)
  Blueberry

    8-12
    (20* Q)
    (4  Ib/gal  EC)
                                    Tolerance. Use. Limitations
20 (I) ppm (alfalfa,  grasses)
50 (I) ppm (alfalfa,  grasses,  hay)
Do not graze or harvest treated crop -For
forage within 40 days of treatment.
Genera1 Informat i on;   Includes mixed
stands of alfalfa and orchardgrass,  tall
fescue, or smooth bromegrass.

SUM - Use limited to KY.
Postemergence.  Broadcast.  For control of
chickweed.  Apply in 20 to 40 gallons of
water per acre to established stands.  Use
the lower dosage before chickweed emerges
until chickweed is 3 inches,tall and the
higher dosage when chickweed is over 3
inches tall and/or after February 1.

0.3 (I) ppm (beans, dried, succulent)
General Information!  Seeds should  be
planted at least 1 inch deep.

Preemergence.   Broadcast or band.   May  be
applied in 20 to 4O gallons of water per
acre after planting but before bean plants
emerge.

0.3 (I) ppm
Dormant application.  Directed spray  to
soil.  Apply in 40 gallons of water per
acre in late winter or early spring.
Avoid wetting canes.

0.3  (I) ppm

Dormant application.  Directed spray  to
base of blueberry plants.  Apply  in 40
gallons of water per acre  in the  fall.
Retreat in the spring before weed growth
begins.
          Issueds  10-15-86
                        I-O18301-6
                                      no

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                       EPA Compendium of Acceptable Uses

                      ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE
/14003AA
          Site. Dosage and
          Formulat ion
           (Ib a. i. /A)
Carrots
/23003AA
  4-6
  (2OX G)
  (4 Ib/gal EC)

Clover
              4
              (20* G)
              2-4
              (4 Ib/gal EC)
/OlOlOftA    Cranberry
              1O-2O
              (SOX G)
                       Tolerance.  Uao.  Limitat tons
0. 1 (I) ppm
General Information;  Do not use in CA.
Use the lower dosage on clay loam soils
and the higher dosage on heavy,  dark miner-
al  or muck-soils.

Preemergence.  Broadcast or band.  Apply
in 20 to 40 gallons of water per acre.
20 (I) ppm (clover)
SO (I) ppm (clover, hay)
40 day preharvest interval.
Do not graze or feed treated crop within
40 days of application.
General Information!  Seedling crops
•hould have at least 4-true leaves.  Do
not use on grass-clover stands as grass
may be injured.  Apply when soil is moist.

Postemergence.  Broadcast or band.  Apply
to the late summer seeded or established
clover plantings.

Postemergence.  Broadcast or band.  Apply
in 20 to 40 gallons of Mater per acre  to
late summer seeded or established dormant
plantings.

0.3 (I) ppm
Genera1 Informati oni  Apply when plants
are dry to avoid contact and possible  in-
jury to fruit  buds and  loss of yield.  Do
not allow chemical to contact sensitive
crops such as  beets, spinach, and  toma-
toes.

Dormant application to  established plant-
ings.  Broadcast.  Apply  in the  early  win-
ter after harvest  or  in early spring  be-
fore cranberry growth begins.
          Issued!  10-13-66
                      1-018301-7

                          111

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          Sit<
       EPA Compendium of Acceptable Uses

     ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

Dosaoe and         To1erance.  Use.  L i m i t at i ons
          Formulation
          (Ib a. i. /A)

            Cranberry (continued)

              CMAI3
              S
              (5* G)
/14007AA    Garlic
              (4 Ib/gal EC)
              (4 Ib/gal EC)
              CSLN:
              2-4
              (4 Ib/gal EC)
              CSLN]
              4
              (4 Ib/gal EC)
                   Use limited to MA.   Dormant  application  to
                   established cranberry plantings.   Broad-
                   cast.   Apply prior to bud break,  from
                   April  1 to May 10,  by ground or by air.
                   When using ground equipment,  it is sug-
                   gested that a piece of canvas or burlap  be
                   dragged behind the application (over the
                   plants) to brush any granules adhering to
                   the foliage onto the soil suface.
                   Formulated with sodium N-1-naphthylphthala-
                   mate.

                   0.1 (I) ppm
                   3O day preharvest interval.
                   General Information  Do not us* on light,
                   sandy soils or soils containing less than
                   1 percent organic matter.  Irrigate within
                   5 days of application.

                   Use limited to CA.   Preemergence.   Broad-
                   cast or band.  Apply in 20 to 70 gallons
                   of water per acre to fall seeded sets im-
                   mediately after planting.

                   Use limited to CA.   Postemergence.  Direct-
                   ed spray to the lower 1 to 2 inches of  gar-
                   lic plant.  Avoid wetting plant tops.   Ap-
                   ply in 20 to 70 gallons of water per acre.

                   SLN - Use limited to CA.
                   Preemergence.  Broadcast or band.  Apply
                   in 20 to 70 gallons of water per acre to
                   fall .seeded set immediately after  plant-
                   ing.  Use the lower dosage on  coarse-
                   textured soils or when soil temperatures
                   are below SO F  (15.5 C) and the'higher
                   dosage on medium/fine-textured soils  or
                   when soil temperatures are  above  60 F
                   (15.5 C).

                   SLN - Use limited to CA.
                   Postemergence.  Directed spray to the low-
                   er  1 to 2 inches of the  garlic plant.   Ap-
                   ply in 20 to 70 gallons  of  water  per  acre
                   when garlic plants  are 6 inches tall  and
                   have 3 or more  true leaves.   Avoid wetting
                   plant tops.
          Issuedt  10-15-86
                  I-O18301-8
                                        112

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                        EPA Compendium of Acceptable Uses

                      ISOPROPYL N-<3-CHLOROPHENYL)CARBAMATE
          Site.  Dosage and
          Formulation
          (Ib a. i. /A)

/28066BA    Grasses.  Perennial
             (seed  crop)
               (4 Ib/gal EC)
/23016AA
/23014AA
/23019AA
/23017Afli
            Ladino Clover
            Red Clover
            Trefoi1
            White Clover
              2-4
              <4 Ib/gal EC)
/14011AA
           Onion
              4-8
              (£0% 6)
              (4 Ib/gal EC)
          Issuedi  10-15-86
                                   Tolerance. Use. Limitations
 SO (I)  ppm  (grass)
 50 (I)  ppm  (grasses,  hay)
 30 day  preharvest  interval.
 General  Information;   Do  not  use  on  new
 varieties or selections without small  plot
 testing  to  determine  crop tolerance.   Only
 true perennial .varieties  are  tolerant.
 Crosses  with annual varieties may be sus-
 ceptible to crop injury.   Apply prior to
 October  20  for  fine fescue varieties.

 Use limited to  OR, west of the Cascade
 Mountains.   Postemergence.  Broadcast or
 band to  established grass stands  which
 have been harvested for seed  at least
 once.   Apply in the fall  after the rains
 have started but before November  1.   The
 dosage  for  this site  was  not  listed on the
 label.

 2O (I)  ppm  (clover)
 50 (I)  ppm  (clover, hay)
 40 day  preharvest  interval.
 Genera1  In format i on:   Seedling crops
 should  have at  least  4-true leaves.   Do
 not use on  grass-clover mixed stands as
 grass may be injured. Apply  when soil is
 moist.

 Postemergence.   Broadcast or  band.  Apply
 in 20 to 40 gallons  of water  per  acre to
 late summer seeded or established dormant
 plantings.

 O. 1 (I)  ppm
 3O day  preharvest interval.
 General  Information:   Do  not  use on sandy
 soils,  coarse-textured soils or  soils con-
 taining less than 4 percent organic mat-
 ter.  Do not apply during flag stage  as  in-
 jury to onions may occur.  Use the  lower
 dosage  on heavy, dark mineral soils  and
 the higher dosage on muck soils  or  when
 soil temperatures are above 6O F (15.5 C).

 Preemergence.  Broadcast  to sets or  seeded
 onions.   Apply up to the early loop stage
 of seeded onions.  The 4 pound per  gallon
 emulsifiable concentrate  formulation is
 not recommended for  use  in CA.

1-018301-9
                                         113

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/14013EA
          Site. Dosage and
          Formulation
          (Ib a. i./A)

            Onion (continued)

              4-8
              (20* G)
              (4 Ib/gal EC)
Potato
           EPA Compendium of Acceptable Uses

         ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

                       Tolerance.  Use.  Limitations
              0.09-0.13 gal
               diluted spray/
               1,000 Ib potatoes
              (25% EC)
              (3 Ib/gal EC)
              1.7-2.2 Ib a. i. /
               1,OOO Ib potatoes
              (4,  4.3,  7 Ib/gal
               RTU)

              CSLN3
              1.7 Ib a. i. /1,000
               Ib potatoes
              (7 Ib/gal RTU)
          Issued:   10-15-86
 Postemergence.   Broadcast  to  sets,  seeded
 or  transplanted  onions.  Apply  when onions
 are 6 inches tall  and  have 3  or more  true  «
 leaves.

 50  ppm
 General  Information;   Apply when potatoes
 enter storage bins or  at the  time of  grad-
 ing or sorting.
 Do  not apply in  fields or  on  seed pota-
 toes.  Apply after bruises and  cuts on
 potatoes have healed  (minimOm 2 weeks).
 Do  not allow vapors to come in  contact
 with,  or get near  storage  areas used  for
 seed  potatoes.   If entry  into the storage
 area  is  necessary  during  or immediately
 following application  (before the fog has
 settled),  protective clothing and respira-
 tors  must be worn.  Treated storage areas
 should be monitored to prevent  overheat-
 ing,  assure proper air flow,  and prevent
 excessive moisture build-up.

 Postharvest.  Plant regulator (sprout inhi-
 bitor).   Apply 1 gallon of product in 24
 to  35 gallons of water.   Apply  diluted
 spray using nozzles placed evenly across
 the rollers on which the potatoes are mov-
 ing.   Potatoes must be cured, washed and
 damp  dried before treatment.

 Postharvest.  Plant regulator  (sprout inhi-
 bitor).   Apply after  curing but before
 sprouting.  Forced air distribution:  In-
 sert  aerosol generator intake hose into
 product  container.  Set air ducts  for re-
 circulation.  Place exhaust end of aerosol*
 generator at center of air mixing  chamber
 (plenum) pointing it  in direction  of air
 flow.  Keep storage closed during  applica-*
 tion  and for 48 hours after treatment.
 Continue to recirculate air  in storage
 areas until fog has settled then resume
 norma1 vent i1at i on.
              OR
 Areas without recirculating  air  systems:
 Prior to placing potatoes  in treatment
 areas the following preparations  should be

I-O183O1-10
                                         114

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Site. Dosage and
Formulation
(Ib a. i./A)

  Potato (continued)
             EPA Compendium of Acceptable Uses

           ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

                         To1eranee. Urn*.  L imi t at ions
    CSLN3
    1.7-3.3 Ib a. i./
     1,000 Ib potatoes
    (4 Ib/gal RTU)
  Raspberry

  Red Clover
                         made.   On the floor,  install an air duct
                         (12 inches by IS inches)  running the
                         length or width of the potato pile.  Leave
                         a false Mall space at both ends for air
                         circulation.  At the end of each duct (in
                         the false wall space) where the fog is to
                         be introduced, place a squirrel cage fan
                         positioned to force air through the duct.
                         Block the exhaust end of the duct to force
                         air up through the piles of potatoes.
                         When potatoes are ready for treatment,
                         close off ventilating systems,  start squir-
                         rel cage fan and introduce fog as near as
                         possible to the bottom of the false wall
                         space containing the fans.  Keep the fans
                         operating until the fog has settled.  Re-
                         activate the ventilation system 48 hours
                         after treatment.

                         SLN - Use limited to ID, ND, OR and WA.
                         Postharvest.  Plant regulator  (sprout inhi-
                         bitor).  For treatment of potatoes  in
                         forced air or refrigerated storage areas.
                         Use the lower dosage when storing  potatoes
                         for 8 to 3 months at 45 F  (7.2 C)  to 50  F
                         (10.0 C) and the higher dosage when stor-
                         ing potatoes for 4 to & months at  50 F
                         (10.0 C).  Do not retreat storage  areas
                         until potatoes have  been analyzed  for resi-
                         dues.  When residue  levels decrease  to 4
                         parts per million, retreat at  a rate  of
                         1.7 pounds active ingredient per 1,000
                         pounds of potatoes.  A maximum of  3.3
                         pounds active  ingredient  per 1,OOO pounds
                         of potatoes may be applied within  any &
                         month period.

                         See Blackberry cluster.

                         See Ladino  Clover cluster.
Issuedi  10-15-86
                        1-018301-11
                               11.5

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                       EPA Compendium of Acceptable Uses

                     I30PROPYL N-(3-CHLOROPHENYL)CftREAMATE
/28076AA
          Sit a. Dosage and
          Formulation
           (Ib a. i./A)
Saf flower
              3-6
              (4 Ib/gal EC)
/I5008AA
Southern Peas
/28023AA
  4-6
  (20* G)

Soybeans
              2-3
              (20* G)
              (4 Ib/gal EC)
              2-3
              (4 Ib/gal EC)
              2-3
              (4 Ib/gal EC)
                       Tolerance. Use. Limitations
 0.1  (I)  ppm  (safflower  seed)
 General  Information;  Irrigate  following
 application.

 Preplant  incorporate.   Broadcast.   Apply
 in 35 to  50  gallons  of  water  per  acre  with-
 in 1  to  3 days  of  planting.   Shallow  incor-
 porate 1  to  2 inches.   Use 3  pounds active
 ingredient per  acre  on  sandy  soils, 4
 pounds active ingredient  per  acre on  clay
 soils,  and 6 pounds  active ingredient  per
 acre  on  peat soils.

 0.3 
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             EPA Compendium of Acceptable Uses

           ISOPROPYL N-<3-CHLOROPHENYL>CARBONATE
Site. Dosaoe and
Formulation
(Ib a. i. /A)

  Soybeans (continued)
    CMAI3
    2-4
    <5*, 10.3X G)
    (1.33 Ib/gal EC)
    CM ft 13
    3-4
    (a Ib/gal EC)
    CMAI3
    1. 3-a. S
    (2 Ib/gal EC)
To1erance. Use. L i m i t at i ons
of the  profluralin and trifluralin tank
mix application and within minutes after
the vernam tank mix application.

Preemergence.  Broadcast or band.  Apply
Mithin  48 hours of planting soybeans  and
before  weed emergence.   In the  black  soil
areas of western  IN,  southern MS, northern
IA and  IL the dosage  should be  reduced by
half.   Do not soil incorporate.
Formulated with sodium N-1-naphthylphthala-
mate.
             OR
Preemergence.  Broadcast or band.  Apply
in 30 to 40 gallons of water per acre with-
in 48 hours of planting  soybeans and  be-
fore weed emergence.  Do not use on  fine-
textured silt  loam soils.
Formulated with sodium N-1-napthylphthala-
mic acid.

Preemergence.  Broadcast or band.  Apply
in 3O to 40 gallons of water  per acre by
ground  or S or more gallons of  water per
acre by air within 48 hours of  planting
soybeans and before weed emergence.   Use
the  lower dosage  on  light  soils and  the
higher  dosage  on  black soils  with extreme-
ly high organic matter.
Formulated with sodium N-1-naphthylphthala-
mate.

Preemergence.   Broadcast.   Apply in 20 to
40 gallons of  water  per  acre.
Tank mix with  alachlor.
Formulated with sodium  N-1-naphthylphthala-
mate.
Issuedi  10-13-86
1-018301-13
                               117

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                       EPA Compendium of Acceptable Uses

                     ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE
                Dosaoj
           ind
          Formulation
           (Ib a. i.
/13024AA
Tolerance.  Use.  Limitations
Spinach (fall seeded)   0.3 (I)  ppm
                       30 day preharvest interval.
                       General  Informations   Not recommended for
                       use in CA.   Do not apply when air tempera-
                       ture is above 75 F (23.9 C).
              1-2
              (4 Ib/gal EC)
              CSLN:
              2
              (4 Ib/gal EC)
              CSLN3
              1-2
              (4 Ib/gal EC)
/280200A    Sugar Beet*
              4
              (4 Ib/gal EC)
              CSLN3
              3-4
              (4 Ib/gal EC)
          Issued!  10-13-86
                       Preemergence.   Broadcast or band.   Apply
                       in 4O gallons of water per acre after
                       planting.   Use the lower dosage when air
                       temperature is below 60 F (15.5 C)  and the
                       higher dosage when air temperatuVe is
                       above 60 F (15.5 C).

                       SLN - Use limited to AR and'OK.
                       Postemergence.  Broadcast or band.   For
                       control of bittercress, chickweed.  henbit.
                       and sibara.   Apply in 20 to 40 gallons of
                       water per acre,  between November 1 and
                       February 15,  when spinach plant has 6 to 8
                       leaves.

                       SLN - Use limited to MD and VA.
                       Postemergence.  Broadcast or band.   Apply
                       in 20 to 4O gallons of water per acre, be-
                       tween November 1 and February  1, when spin-
                       ach plant has 6 to 8 leaves.   Use the low-
                       er dosage on coarse-textured soils and the
                       higher dosage on all other soil textures.

                       0.1 (I) (beets,  sugar, roots)
                       0.3 (I) (beets,  sugar, tops)
                       General Informationi   Irrigate within 7
                       days of application.   Use the  lower dosage
                       on coarse-textured soils and the higher
                       dosage on fine—textured soils.

                       Use limited to Imperial Valley, CA.   Post-
                       emergence.  Broadcast  or band.  For con-
                       trol of grain (volunteer) and  winter  an-
                       nual grasses.  Apply  in  10 to  40 gallons
                       of water per acre when sugar beet  plants
                       have 2 to 6-true  leaves.

                       SLN - Use limited to  Imperial  Valley,  CA.
                       Postemergence.  Apply  into the irrigation
                       water system during the  entire irrigation
                       period when sugar beet plants  have at
                       least 8-true  leaves.   Do not  use runoff
                       water  for domestic  purposes  or to  irrigate
                       other crops.

                      I-O18301-14
                                         118

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                       EPA Compendium of Acceptable U»»s

                      ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE
          Site. Dosage and
          Formulation
           (Ib a. i./A)

            Suoar Beeta  (continued)

              CSLN:
              4
              (4 Ib/gal EC)
 Tolerance. Use. Limitations
/S8O2OBA    Sugar Beets  (seed
             crop)
              CSLN:
              3-4
              (4 Ib/gal EC)
/11005AA    Tomato
              (4 Ib/gal EC)
              CSLN3
              4
              (4 Ib/gal EC)
 SLN  -  Use  limited  to  CA.
 Broadcast  to  winter fallow  beds to  be
 spring planted  with sugar beets.  Apply  in
 20 to  40 gallons of water per  acre  by
 ground or  10  gallons  of  water  per acre by
 air  in late fall after bed-up.  Do  not
 plant  sugar beets  within SO days of appli-
 cation.

 O.I  (I)  (beets, sugar, roots)
 0.3  (I)  (beets, sugar, tops)
 Genera1  Informationi  Use the  higher dos-
 age  when heavier  infestation or more ma-
 ture weed  growth  is present.   Do not apply
 to fields  saturated from recent rainfall
 or to  sugar beet  plants  under  stress from
 insect,  disease,  or other environmental
 factors.   Irrigate after application.

 SLN  -  Use  limited  to  OR.
 Postemergence.   Broadcast.   For control  of
 ehickweed  and winter  annual weeds.   Apply
 in 10  or more gallons of water per  acre
 when sugar beet plants  have 8  or  more true
 leaves.
 0. 1  (I)  ppm
 General  Information!
 days of  application.
                                                          Irrigate within 5
 Postemergence.   Directed spray to the base
•of tomato plants.   Apply in 20 to 40 gal-
 lons of water per acre when crop is well
 established.   Avoid wetting plant foliage.

 SLN - Use limited to CA.
 Broadcast to winter fallow beds to be
 spring planted with tomatoes.  Apply in 20
 to 40 gallons of water per acre by ground
 or 10 gallons of water per acre by air in
 late fall after bed-up.  Do not plant toma-
 toes within 8O days of application.
          Issuedi  10-13-86
I-0183Q1-15
                                         119

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                       EPA Compendium of Acceptable Uses

                     ISOPROPYL N-< 3-CHLOROPHENYL)CARBAMATE

                                   Tolerance.  Use.  Limitations
Site.  Dosage and
Formulation
(Ib a. i. /A)

  Tomato  (continued)
                 (piug-pi anted tomatoes)
              CSLN]                SLN - Use limited to CO.
              £-4                  Prep1ant.  Broadcast or band to tomatoes
              (4 Ib/gal EC)        seeded in plugs of an artificial growing
                                   mix containing 60 ml to 120 ml of a SO:50
                                   mixture of peat and vermiculite and at
                                   least 5•percent volume activated charcoal.
                                   Apply in 20 to 60 gallons of water per
                                   acre to the bed tops prior to planting.
            Trefoi1

            White Clover
                         See Ladino Clover cluster.

                         See Ladino Clover cluster.
          TERRESTRIAL NONFOOD CROP
/26006AA
  (Agricultural  Crops)

  Tobacco.  Flue-Cured
              1.0-1.5
              (1 Ib/gal EC)
N.F.
General Information:  Do not apply if rain
is expected within 4 hours of application.
Do not use on tobacco grown for seed.  Do
not tank mix with other sucker control
agents.  Applications to immature plants
may result in leaf distortion on the upper
portion of the plant.  Do not apply to se-
verely wilted, drought stricken, or water
logged tobacco.   Apply in the mornings and
on cloudy days when tobacco is actively
growing and soil moisture is ample.  Make
application following the use of one or
more contact agents  (fatty alcohol)  plus  a
systemic agent (such as potassium salt of
maleic hydrazide) application.  Do not ap-
ply in less than 40 gallons of water per
acre.

Postemergence.  Broadcast.  Plant regula-
tor (prevent sucker development).  Apply
in 40 to 50 gallons of water  per acre  5  to
7 days after the systemic agent  is ap-
plied.  This dosage applies to  fields  with
a plant population of 5,000 to  7,000.
          Issued:  10-15-88
                        1-018301-16
                                     120

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                       EPA Compendium of Acceptable Ui

                      ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

                                   To1eranee. Use.  L im i t at ions
Site. Dosage and
Formulation
(Ib a. i./A)
             (Ornamental Plants and Forest Trees)
 /31013DA    flqeratum
 /31017DA    Alvssum
 /31034DA    Benonia
 /31065DA    Chrysanthemum
 /31071DA    Coleus
 /31087DA    Dianthus
 /31106DA    Garden Balsam
 /31108DA    Geranium
 /31137DA    Marigold
 /31149DA    Pansies
 /311S4DA    Petunias
 /31171DA    Salvia
 /31184DA    Snapdragon
 /31213DA    Zinnia

              4-6
              (20* 6)

 /3502IDA    Arborvitae
 /34022DA    Azalea
 /35O26DA    Balsam Fir
 /340250A    Barberry
 /3S028DA    Birch
 /34031DA    Boxwood
 /34036DA    Camellia
 /35O37DA    Cedar
 /3SO55DA    Cherry (ornamental)
 /34O45DA    Cotoneaster
 /3SOS60A    Crabaoole (ornamen-
             tal)
 /35043DA    Dogwood
 /34255DA    Enkianthus
 /34053DA    Euonvmum
 /3505IDA    Fir
 /34062DA    For«vthia
 /31104DA    Fuchmia
/34068DA    Heather
 /35068DA    Hemlock
 /34070DA    Hollv
 /34O72DA    Honeysuckle
 /34073DA    Hydrangea
 /35073DA    Junioer
 /34215DA    Laurel
 /34087DA    Leucothoe
/34088DA    Lioustrum
 /34089DA    Lilac
/35077DA    Locust
/35O82DA    Magnolia

          Issuedi  10-15-86
                         Genera1  In format i oni   Do not  use over 4
                         pounds active  ingredient per  acre on alys-
                         sum,  pansies,  petunias or salvia.  Use the
                         higher dosage  on medium/fine-textured
                         soils.
                         Posttransplant
                         transplants.
Broadcast to established
                         General  Informationi   Do not apply to nurs-
                         ery stock that is to be transplanted with-
                         in 30 days of treatment.   Use the higher
                         dosage on medium/fine-textured soils.
                        1-018301-17

                             121

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                        EPA Compendium of Acceptable Uses

                      ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE
 /34090DA
 /35083DO
 /34094DA
 /34111DA
 /35096DA
 /350600ft
 /35101DA
 /34555DA
 /34120DA
 /34130DA
 /33116Dfi
 /35119DA
 /341370ft
 /331300ft
 /320010ft
/31O26AA
/31O87AA
/31402ftft
/31037AA
/31074«ft
/31072AA
/33l60ftft
/33030flft
/31101flft
/311290ft
/33044AA
/33041AA
/31151AA
/34226ftft
/31063AA
/310S4AA
/31382flfl
/31111ftft
           Site.  Dosage  and
           Formulation
           (Ib a. i./A)
                         Tolerance. Use.  Limitations
  Arborvitae cluster  (continued)

  Mahonia
  Maole
  Mock-Orange
  P i er i s
  Pine
  Plum < ornament a1)
  Poplar
  Rhododendron
  Rose
  Soirea
  Spruce
  Sycamore
  Viburnum
  Yew
              4-8
              <20X G)
              (4 Ib/gal EC)
  Aster
  Ast i 1 be
  Bluebell
  Carnation
  Coral Bells
  Columbine
  Creeping Juniper
  English Ivv
  Foroet-Me-Not
  Larkspur
  Mvrtle
  Pachvsandra
  Peonies
  W i nt ercreeoer

    4-6
    (20* G)
  Daffodils (bulbs)
  Dahlias (bulbs)
  Dutch Iris (bulbs)
  Gladiolus (bulbs)

    4-6
    (20% G)

Issuedi  10-15-66
                         Dormant application to established trees
                         and shrubs.  Broadcast or directed spray«
                         Apply in late fall through early spring be-
                         fore new plant growth starts.  May be ap-
                         plied in 4O gallons of water per acre.
 Genera1  Informat i on:   Use the higher dos-
 age on medium/fine—textured soils.
                                   Dormant  application to established plant-
                                   ings.  Broadcast.   Apply in the spring be-
                                   fore  plant  growth  begins.
 General Information!  Use the higher dos-
 age on medium/fine-textured soils.


 At planting or prior to crop and weed emer-
 gence.  Broadcast.

1-016301-16

    122

-------
 /31093AA
/31126AA
/35O62AA
/31131AA
/31142AA
/31205Aft
Site. Dosage and
Formulation
(Ib a. i. /A)

  Easter Lilies
                        EPA  Compendium of Acceptab10 Uses

                      ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

                                   Tolerance. Use. Limitations
               CSLN3
               4
               (1, 4  Ib/gal EC)
  Iris
               CSLN3
               1
               (4  Ib/gal EC)
  Ginkao
               CSLND
              2 Ib «. 1. /100 gal-
               lons of water
               (4 Ib/gal EC)
Lilies (bulbs)
Narcissus (bulbs)
Tulios (bulbs)

  4-6
  (20X 8)

  CSLN3
  4
  (4 Ib/gal EC)
                         General  Information;   Some yellowing  may
                         occur and stem elongation will  be retard-
                         ed.

                         SLN - Use limited to  OR.
                         Postemergence.   Broadcast.   Plant regula-
                         tor (flower bud abscission).   Apply in 300
                         gallons  of water per  acre,  directly to
                         tops of  lilies,  when  lily buds are one-
                         eighth to one-half inch long.
                         SLN - Use limited to Santa Cruz County,
                         CA.
                         Preemegence.   Broadcast.   For control of
                         mallow.   Apply in 20 to 100 gallons of
                         water per acre after planting but no later
                         than 14 days before emergence of bulbs.
                         Genera1 Informati oni  Do not apply when
                         temperatures are above 60 F (26.& C).

                         SLN - Use limited to DC.
                         Postemergence.   Plant regulator (fruit in-
                         hibitor).  Apply within 3 weeks following
                         pollenation (third week in April).  Spray
                         with a mist blower to the near dripping
                         point.
                         General Informationi  Use the higher dos-
                         age on medium/fine-textured soils.

                         At planting or prior to crop and weed emer-
                         gence.  Broadcast.

                         SLN - Use limited to WA.
                         Preemergence.  Broadcast.  For control of
                         winter annual weeds.  Apply in 30 to 60
                         gallons of water per acre after planting
                         and final hilling but no later .than 2
                         weeks before bulb emergence.  Apply in
                         late September through October when soil
                         surface is moist but before soil  becomes
                         water-logged.
          Issued!  10-15-86
                        1-018301-19
                                      123

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           Sit(
             EPA Compendium of Acceptable Uses

            ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

      Dosaoe and         Tolerance. Use. Limitations
           Formulation
           (Ib a. i. /A)

             Li 1ies (bulbs)  cluster  (continued)
               CSLN3
               2
               (4  Ib/gal  EC)
                         Tank mix with dinoseb, triethanolamine
                         salt or dinoseb, alkanolamine salts or
                         dinoseb, diethanolamine salt.

                         SLN - Use limited to WA.
                         Postemergence.  Broadcast.  For control of
                         summer annual weeds.  Apply in 30 to 60
                         gallons of water per acre in the early
                         spring before weed seed germination.  Do
                         not apply later than April 15.
/32001DA
  Ornamental Woody
   Plants
                                    Refer to Arborvitae cluster for dose and
                                    use  information.
9001500
AAAAAAA
AERIAL AND TANK MIX APPLICATIONS

  Aerial Application

    —                   Refer to
9900300
AAAAAAA
  Tank Mix
                                    TERRESTRIAL FOOD CROP
                                     (Agricultural  Crops)
                                    Alfalfa,  Alfalfa (seed crop),  Soybean,
                                    Sugar Beets,  Tomato
                                    Refer to

                                    TERRESTRIAL FOOD CROP
                                     (Agricultural Crops)
                                    Alfalfa,  Alfalfa (seed crop), Soybean

                                    TERRESTRIAL NONFOOD CROP
                                     (Ornamental Plants and Forest Trees)
                                    Lilies (bulbs).  Narcissus (bulbs), Tulip
                                    (bulbs)
          Issuedi  10-15-66
                        1-018301-20
                                      124

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                        EPA Compendium of Acceptable Uses

                      ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

           Listing of Registered  Pesticide Products by Formulation

 4O98.OOO1  98* technical  chemical
             isopropyl  N-<3-chlorophenyl)carbamate  (018301)
               002743-00102   002749-00117

 &005.0004  5X  granular
             isopropyl  N- (3-chloropheriy 1) carbamate  <018301) plus sodium N-l-
              napthylphthalamic acid  (030703)
               000400-00065

 4010.3004  10.3%  granular
             isopropyl  N-(3-chlorophenyl)carbamate  (018301) plus sodium N-l-
              napthylphthalamic acid  (030703)
               000400-00087

 4020.0004  20* granular
             isopropyl  N-(3-chlorophenyl)carbamate  (018301)
               000748-00163

               (000748-00163)       COS10064  UTS10030     ,

 4211.90:12  11.9%  (1  Ib/gal)  emulsifiable concentrate
            isopropyl  N-(3-chlorophenyl)carbamate  (018301)
               OOO748-OO233

               (OOO748-OO233)       OR850001

 4215. 001L2  1SX (1.33  Ib/gal) emulsifiable concentrate
            isopropyl  N-(3-chlorophenyl)carbamate  (018301) plus sodium N-l-
              napthylphthalamic acid  (030703)
               000400-00071

 4222.2012 £2.2*  (2  Ib/gal)  emulsifiable concentrate
            isopropyl  N—(3-chlorophenyl)carbamate  (0183O1)
               0004OO-00083

 4225.0012 S3*  emulaifiable concentrate
            isopropyl  N-<3-chlorophenyl)carbamate  (018301)
               OO279a-OOO4O

4236.0012 36X  (3 jEk/nal) emulsifiable concentrate
            isopropyl  N—(3-chlorophenyl)carbamate  (0183O1)
               OOO748-O0188   002749-00070

4247.0012 47»  (4 Ib/oal) emulsifiable concentrate
            isopropyl  N-(3-chlorophenyl)carbamate  (01S3O1)
               000748-00161

               (000748-00161)       RR780025  AZ800O30   C«780103  C078O197
                                   CA790007  CA790054   CA860046  DC800001
                                   KY780006  MD780017   OK780O24  OR840042
                                   OR850001  VA780027   WA79OO12


          Issuedi  10-13-86      X-O18301-21

                                       125

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                        EPA Compendium  of Acceptable

                      ISOPROPYL N-(3-CHLOROPHENYL)CARBAMATE

           Listing of Registered  Pesticide  Product* by Formulation  (continued)

 4246.0016  4S*  (4  Ib/oal)  liquid-ready  to use
             isopropyl  N—(3-chlorophenyl)carbamate  (018301)
               OOO748-00178
               (000748-00178)
                       IDS10005  ND810023  OR810020  WAS00086
4246.5016 46.5*  (4  Ib/nal)  liquid-ready  to  use
             isopropyl N- (3-chlorophenyl) carbarnate  (018301)
              002749-00264
               (002749-00264)
                       ND820O21  OR850047  WA82O065
4249.6516 49.65%  (4.3  Ib/oal)  liquid-ready to  uaa
             isopropyl  N-(3-chloroph«nyl)carbamat«  (O18301)
              002792-00041

«278.4116 78.4*  (7  Ib/oal)  liquid-ready  to use
             isopropyl  N-(3-chlorophenyl)carbamate  (0183O1)
                                   ND850009

4278.5016 7S.5%  (7  Ib/oal)  liquid-ready  to use
             isopropyl  N-(3-chlorophenyl)carbamate  (0183O1)
              000748-00234
               (000748-00234)
                       XD830OO3  OR83OOO1
9999999   State Label Registrations


                             OO0748-1OS6O
CO Reg. No.
  OO0748-06OO8
            ID Reg. No.
              000748-06007

            NJ Reg. No.
              OOO4OO-O6436

            NY Reg. No.
              038695-10438

            OR Reg. No.
              000748-060O9

            TX Reg. No.
              000478-06005

            WO Reg. No.
              000748-06006
                 038655-10447
          Issuedi  10-15-66
                       1-018301-22
                          126

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             EPA Compendium of Acceptable Use*

           ISOPROPYL N-<3-CHLOROPHENYL>CARBAMATE

Listing of Registered Pesticide Products by Formulation  (continued)

  WI Reg?* No.
    000400-06300
Issuedi  10-15-86       I-018301-23
                              127

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             EPA Compendium or Acceptable U*e*

            ISOPROPYL N-<3-CHLOROPHENYL>CARBAMATE.

                       Appendix 0-1
       -,«Nr.
Listing^jfcf Active  Ingredient (a) Found  in Combination with the
  Report Chemical

Chemical    Common Name                            EPA Acceptable
  Code        (source)                          Common/Chemical Name

030703      sodium N-1-naphthylphthalamate     —


— Use Common Name
Z ssuedi  10-15-86        I-018301-24

                               128

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             EPA Compendium of Acceptable Ui

           I80PROPYL N-<3-CHLOROPHENYL>CftRBAItftTE

                       Appendix A-2

Listing- of Active Ingredient Which May Be Included in Tank Mixes
Chemical
  Code

090501

056801

037511
037514

037506

106601

041404


036101
Common Name
 (source)

alachlor

carbaryl

dinoseb, alkanolamine salt
dinoseb,  diethanolamine salt

dinoseb,  triethanolamine salt

profluralin

vernam


trifiuralin
    EPA Acceptable
Common/Chemical Name
dinoseb, alkanol-
amine salts of the
ethanol and iso—
propanol series
8-propyl dipropyl-
t h iocarbamate
— Use Common Name
Issuedi  10-15-66
            I-O18301-25
                              129

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                             BIBGUIDE-1-

               GUIDE TO  USE OF THIS BIBLIOGRAPHY


 1.   CONTENT OF BIBLIOGRAPHY.  This bibliography contains
     cicacions  of  all studies considered relevant by EPA in
     arriving at the positions and conclusions stated elsewhere
     in the Standard.  Primary sources for studies in this
     bibliography  have been the body of data submitted to EPA
     and  its  predecessor  agencies in support of past regulatory
     decisions.   Selections from other sources including the
     published  literature, in those instances where they have
     been considered,  will be included.

 2.   UNITS  OF ENTRY.   The unit of entry in this bibliography
     is called  a "study."  In the case of published materials,
     this corresponds  closely to an article.  In the case of
     unpublished materials submitted to the Agency, the. Agency
     has  sought  to  identify documents at a level parallel to
     the  published  article from within the typically larger
     volumes  in  which  they were submitted.  The resulting
     "studies"  generally  have a distinct title (or at least a
     single subject),  can stand alone for purposes of review,
     and  can  be  described with a conventional bibliographic
     citation.   The  Agency has attempted also to unite basic
     documents  and  commentaries upon them, treating them as a
     single study.

 3.   IDENTIFICATION  OF ENTRIES.  The entries in this bibliography
     are  sorted  numerically by "Master Record Identifier," or
     MRID, number.  This  number is unique to the citation, and
     should be used  at any time specific reference is required.
     It is not  related to the six-digit "Accession Number"
     which has been  used  to identify volumes of submitted
     studies; see paragraph 4(d)(4) below for a further  explana-
     tion.  In a few cases, entries added to the bibliography
     late  in  the review may be preceded by a nine-character
     temporary identifier.  These entries are listed after
     all  MRID entries.  This  temporary identifier number is
     also Co be  used whenever specific reference is needed.

4.   FORM OF  ENTRY.   In addition to the Master Record Identifier
     (MRID),  each entry consists of a citation containing
     standard elements followed, in the case of material
     submitted to EPA, by a description of  the earliest  known
     submission.  Bibliographic conventions used  reflect the
     standards of the  American National Standards  Institute
     (ANSI),  expanded  to  provide for certain  special  needs.
                                 130

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                        BIBGUIDE-2

 a.  Author.  Whenever the Agency could  confidencly identify
    one, che Agency has chosen to show  a  personal author.
    When no individual was identified,  the Agency has
    shown an identifiable laboratory or testing  facility
    as author.   As a last resort, the Agency has shown
    the first submitter as author.

b.  Document Date.  When the date appears as four digits
    with no question marks, the Agency  took  it directly
    from the document.  When a four-digit date is followed
    by a question mark, the bibliographer deduced the
    date from evidence in the document.   When  the date
    appears as  (19??), the Agency was unable to  determine
    or estimate the date of the document.

c.  Title.   In  some cases, it has been  necessary for
    Agency bibliographers to create  or  enhance a document
    title.   Any such editorial insertions are  contained
    between square brackets.

d.  Trailing Parentheses.  For studies  submitted to  the
    Agency in the past, the trailing parentheses include'
    (in addition to any self-explanatory text)  the  fol-
    lowing  elements describing the earliest  known submission:

    (1)  Submission Date.  The date of  the  earliest  known
         submission appears immediately following the  word
         "received."

    (2)  Administrative Number.  The next element,
         immediately following the word "under," is  the
         registration number, experimental  use permit
         number, petition number, or other  administrative
         number associated with the earliest known  submission.

    (3)  Submitter.  The third element  is the  submitter,
         following the phrase "submitted by."   When
         authorship is defaulted to the submitter,  this
         element is omitted.

    (4)  Volume Identification (Accession Numbers).  The
         final  element in the trailing  parentheses
         identifies the EPA accession number of the volume
         in which the original submission of the study
         appears.   The six-digit accession number follows
         the symbol "CDL," standing for "Company Data
         Library."  This accession number is in turn
         followed by an alphabetic suffix which shows the
         relative position of the study within  the volume.
         For example, within accession  number 123456, the
         first  study would be 123456-A; the second, 123456-
         B;  the 26th, 123456-Z; and the 27th, 123456-AA.
                                131

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                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered to be Part of the Data Base Supporting
              Registrations Under the Chloropropham Standard


    MRID            CITATION

00018842 Atkins, E.L., Jr.; Anderson,  L.D.; Greywood, E.A.  (1969) Effect of
            Pesticides on Apiculture:  Project No. 1499; Research Report CF-
            7501.  (Unpublished study  received May 8, 1971  under 1F1174;
            prepared  by Univ. of Call form'a--R1verside, Dept. of Entomology,
            submitted by Ciba Agrochenical Co.,  Summit, N.J.; CDL:090973-B)

00030995 Lane, J.R. (1974) Residue Summary.   (Unpublished study received Mar
            20, 1974  under 400-85; prepared  in  cooperation with State Univ.
            of New York--0swego, Lake Ontario Environmental Laboratory,
            submitted by Un1 royal Chemical,  Bethany,  Conn.; CDL:023356-8)

00035475 Dahmer, L. (1973) Liquid Scintillation  Analysis of Bligh-Byer and
            Soxhlet Fractions from Extractions  of  14C-CIPC-Treated Soybean
            Plants and Seeds Grown at Fargo,  North Dakota, Spring/Summer,
            1972: Research Report No. BR-18625.  Method dated Jun 12, 1973.
            (Unpublished study received on  unknown date under 4F1429; sub-
         .   mitted by PPG  Industries, Inc.,  Barberton,  Ohio; CDL:093808-F).

00035480 Ecke, G.G.;  Ferguson, C.E.; Mitten,  M.E.; et al.  (1973) Agricul-
            tural Chemicals: CCLXXXVII: Qualitative  Investigation of CIPC
            Metabolites in Soybean Shoots:  Research  Report No.  BR-18605.
            (Unpublished study received on  unknown date under 4F1429; sub-
            mitted by PPG Industries, Inc.,  Barberton,  Ohio; CDL:093808-K)

00035485 Gard, L.N.;  Oahmer, L.; Wledmann, J.L.; et  al. (1973)  Analysis of
            14C-CIPC Treated Soybean Plants  for 2- and 4-Hydroxy CIPC: First
            and Second Scheduled Samples Grown  at  Fargo, North  Dakota
            (1972):  Research Report No. 8TS-18580.  Methods  dated May 18,
            1973.  (Unpublished study received on  unknown  date under 4F1429;
            submitted by PPG Industries, Inc.,  Barberton,  Ohio; COL:
            093808-P)

00035488 Krochta, W.G. (1973) A Review of the Studies To Account for the
            Distribution of Radioactive Carbon in  Natural  Products  from
            Soybeans Grown In 14C-CIPC Treated Soils: Research Report
            No. BR-18649.  (Unpublished study received on  unknown date under
            4F1429; submitted by PPG  Industries, Inc., Barberton, Ohio;
            0)1:093808-5)

00035489 Mitten, M.E.; Wledman, J.L.  (1973)  An  Investigation of the Nature
            and Distribution of Radioactivity in  Soybean 011 Obtained from
            Soybeans  Grown  1n Soil Treated with 14C  Ring Labeled Isopropyl-
            N-(3-ch1oropheny1)carbamate at Fargo, North Dakota, 1972: Re-
            search Report No. BR-18591.  Method dated May 29, 1973.  (Unpub-
            lished study received on  unknown date under 4F1429; submitted by
            PPG Industries, Inc., Barberton, Ohio; CDL:093808-T)
                                         132

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                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered to be Part of the Data Base Supporting
              Registrations Under the Chloropropham Standard


    MRID           CITATION

00035490 Parker, J.R. (1973) The Presence of 14C in Ami no Acids from Fargo
            Soybean Seeds:  Anrino Acid Group Separation Using a Dowex 50W-X8
            Strong Acid Ion Exchange Column: Research Report No.  BR-18600.
            (Unpublished study received on unknown date under 4F1429; sub-
            mitted by PPG Industries, Inc., Barberton, Ohio; CDL:093808-U)

00035496 Strang, R.H. (1973) Agricultural Chemicals: CCLVII: Procedure for
            the Growing, Sampling, and Shipping  of Soybean Plants Grown in
            14C-CIPC at Boyce Thompson for CIPC  Plant  Metabolite Analysis:
            Research Report No. BAR-18470.   (Unpublished  study received on
            unknown date under 4F1429; submitted by PPG Industries,  Inc.,
            Barberton, Ohio; CDL:093808-AA)

00035497 Strang, R.H.; Kish, D. (1973) Agricultural Chemicals: CCLII: Pro-
            cedures Used for the Growing  of Turnips, Soybeans  and Orchard-
            grass in the Presence of 14C-CIPC  at Barberton: Research Report
            No. BR-18455.  (Unpublished study  Including letter dated Jan
            25, 1973 from R.H. Strang to  D.C.  Torgeson, received on  unknown
            date under 4F1429; submitted by  PPG  Industries,  Inc.,  Barberton,
            Ohio; CDL:093808-AB)

00035498 Strang, R.H.; K1sh, D. (1973) Agricultural Chemicals: CCLXXXYIII:
            Procedure for the Growing of Soybean Plants Hydroponlcally  1n
            the Presence of 14C-CIPC: Research Report No. BAR-18606.  (Un-
            published study received on unknown  date  under 4F1429;  submit-
            ted by PPG Industries, Inc.,  Barberton, Ohio; CDL:093808-AC)

00035505 Wiedmann, J.L. (1973) The Presence  of 14C in Anrino Adds from Fargo
            Soybean Seeds: Separation of Glutanrfc and Aspartic adds from
            Other Anrino acids: Research Report No. BR-18634.   Method dated
            Jun 15, 1973.   (Unpublished study received on unknown date
            under 4F1429; submitted  by PPG Industries, Inc.,  Barberton,
            Ohio; CDL:093808-AJ)

00035896 Wiedrann, J.L.; Pensyl, J.  (1975) Proposed Regulatory Method for
            CIPC Residue (CIPC + Metabolite III):  BR 19718.  Method dated
            May 2, 1975.  (Unpublished study received May 8, 1975 under
            4F1429; submitted  by PPG  Industries, Inc., Barberton, Ohio; CDL:
            093811-0)

00035995 Smith, K.S.  (1976) Report:  Catfish Tissue Residue Levels following
            Exposure to 14C-CIPC: Laboratory No. 5E-8033.  (Unpublished
            study received  Sep 21,  1976 under 748-161; prepared  by  Cannon
            Laboratories, Inc., submitted by PPG  Industries,  Inc.,  Barber-
            ton, Ohio; COL:095292-C)
                                         133

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                        OFFICE  OF PESTICIDE PROGRAMS
                     REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered to be Part of the Data Base Supporting
               Registrations Under the Chloropropham Standard


    MRID            CITATION

 00035997 Ecke, G.G.  (1976)  Qualitative Investigation of CIPC  Metabolites in
             81ueg11l  Sunflsh:  Final Report:  BR 20315A.   (Unpublished study
             received Sep 21, 1976 under 748-161;  submitted  by PPG Indus-
             tries,  Inc., Barberton, Ohio; CDL:095292-E)
      \
 00035998 Smith,  K.S.  (1976)  Report: Bluegill Sunfish Tissue Residue Levels
             following Exposure to 14C-CIPC:  Laboratory  No.  6E-1100A.  (Un-
             published study  received Sep 21, 1976 under 748-161; prepared by
             Cannon Laboratories, Inc., submitted  by PPG Industries, Inc.,
             Barberton, Ohio; CDL:095292-F)

 00036377 Dahmer, L.;  Coffman,  D.; Wledmann,  J.; et al.  (1973) Liquid Scin-
             tillation Analysis of 14C-CIPC-Treated Soybean  Plants  and Seeds
             Grown at  Fargo,  North Dakota, Spring/Summer, 1972:  Research Re-
             port No.  BR-18288.  Method dated Dec 29, 1972.   (Unpublished
             study Including  research report no. BAR-18127,  received on un-
             known date under 2F1276; submitted by PPG Industries,  Inc., Bar-
             berton, Ohio; CDL:092174-D)

 00036382 Ferguson, C.E.; Gard, L. (1971) Analysis of Soybean Plant Samples
             for  CIPC  Residue:  Sample Grown in Soil Treated  with Tank Mix-
             tures of  CIPC and  Treflan at 7 Locations In Iowa: 1971  Crop:  Re-
             search Report No.  BTS-17390.  (Unpublished study received  on  Oct
             12,  1972  under  2F1276;  submitted by PPG  Industries, Inc.,  Bar-
             berton, Ohio; CDL:092i74-I)

 00036385 Ferguson, C.E.; Gard, L. (1972) Re-confirmation of the Analytical
             Method for Determining CIPC Residues In Soybean Plants:  Minor
             Editorial  Revision and Up-dating of the Colorlmetrlc Analytical
             Procedure: Research Report No. BTS-17989.  Includes method dated
             Jul  24, 1972.   (Unpublished  study  received Oct 12, 1972 under
             2F1276; submitted  by PPG Industries, Inc., Barberton, Ohio;
             COL:092174-L)

00036390 Gard, L.; Holmes,  S.; Ferguson, C.E.  (1972) Analysis  of Ladlno Clo-
             ver  (Seed Crop)  for CIPC Residues: Research Report No. BTS-
             18082.  (Unpublished study received Oct  12, 1972 under 2F1276;
             submitted  by PPG Industries, Inc., Barberton, Ohio; COL:
             092174-Q)

00036392 Gard, L.; Holmes, A.S.; Ferguson, C.E. (1972) Analytical Results
             from  Dissipation of CIPC Applied as Granular Formulations of
             Furloe on Ladlno Clover: Research Report No. BTS-18169.  (Unpub-
             lished study received on unknown date  under 2F1216; submitted by
             PPG  Industries,  Inc., Barberton, Ohio;  CDL:092174-S)
                                          134

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                        OFFICE  OF PESTICIDE PROGRAMS
                     REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered  to be Part of the Data Base Supporting
               Registrations  Under the Chloropropham  Standard


    MRID            CITATION

 00036394 Hardies, D.E.  (1973)  Agricultural Chemicals.  CCXXXIII. Procedure
             for Growing,  Sampling and Shipping of Turnips Grown 1n the Pre-
             sence of 14C  CIPC. A Protocol submitted  to Boyce Thompson for
             CIPC Metabolite  Study: Research Report No. BAR-18316.  (Unpub-
             lished study  received on unknown date under 2F1276; submitted by
             PPG  Industries,  Inc., Barberton, Ohio; CDL:092174-U)

 00036395 Hardies, O.E.  (1973)  Agricultural Chemicals.  CCXXIV. Procedure  for
             Growing,  Sampling  and Shipping of Orchardgrass Grown in the
             Presence of 14C  CIPC. A Protocol Submitted to Boyce Thompson for
             CIPC  Metabolite  Study: Research Report No. BAR-18317. ' (Unpub-
             lished study  received on unknown date under 2F1276; submitted by
             PPG  Industries,  Inc., Barberton, Ohio; CDL:092174-V)

 00036626 Pensyl,  J.  (1973) A Gas Chromatographic Method for  the Determina-
             tion  of l-Hydroxy-2-propyl-3'-chlorocarbanilate in Soybean
             Plants and  Seeds:  Research Report No. BR-18717.  Method dated'
             Jul 27, 1973.  (Unpublished study received Jan 4, 1974 under
             2F1276; submitted  by PPG Industries, Inc., Barberton, Ohio; CDL:
             092175-V)

 00036628  Still, G.G.; Mansager, E.R. (1973)  Soybean  shoot metabolism of  Iso-
             propyl-3-chlorocarbanilate:  Ortho and para aryl hydroxylation.
             Pesticide Biochemistry and Physiology 3(l):87-95.  (Also 1n  un-
             published submission  received Jan 4, 1974  under 2F1276; submit-
             ted by PPG  Industries, Inc., Barberton,  Ohio; COL:092175-Y)

00036629 Still, G.G.; Mansager, E.R. (1973)  Metabolism of Isopropyl-3-
             chlorocarbanllate by  cucumber plants. Journal of Agricultural
            and Food Chemistry 21(5):787-791.  (Also 1n unpublished submis-
             sion  received Jan 4,  1974 under 2F1276;  submitted by PPG Indus-
            tries, Inc., Barberton, Ohio; CDL:092175-Z)

00036630 Strang, R.H. (1973)  Agricultural Chemicals. CCLXXII. Report on  the
            Growing, Sampling and Shipping of Turnips  and Orchardgrass Grown
             In 14C-CIPC Treated Soil at Boyce Thompson for CIPC  Metabolite
            Study: Research Report No.  BAR-18528.  (Unpublished  study  re-
            ceived Jan 4, 1974 under 2F1276; submitted by PPG  Industries,
            Inc,  Barberton, Ohio; COL:092175-AA)

00036632 Strang,  R.H.; Xish,  0. (1973)  Agricultural  Chemicals;  CCCXXXIX;
            Procedure for the Growing of Turnip and  Orchardgrass Plants Hy-
            droponlcally 1n  the Presence of 14C-CIPC: Research Report
            BAR-18936.  (Unpublished study received Jan 4,  1974 under
            2F1276; submitted  by PPG Industries,  Inc.; Barberton, Ohio; COL:
            092175-AC)


                                         135

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                       OFFICE OF PESTICIDE PROGRAMS
                   . REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered to be Part of the Data Base Supporting
               Registrations Under the Chloropropham Standard


    MRID           CITATION

 00036635 Wledmann, J.L.  (1973) Thin Layer Chromatograph-Autoradlogram Evalu-
             ation of the Polar Phase Soluble Metabolites of 14C-CIPC Treated
             Soybean Hay  and Seeds Grown at Fargo, North Dakota in 1972:  Re-
             search Report No. BR-18880.  Method dated Oct 26, 1973.  (Unpub-
             lished study received Jan 4, 1974 under 2F1276; submitted by PPG
             Industries, Inc., Barberton, Ohio; CDL:092175-AF)

 00036636 Wiedmann, J.L.; Mitten, M.E.; Pensyl, J.W. (1973) Tentative Regula-
             tory Methods for Separating and Determining CIPC and Its Metabo-
             lites in Turnip Roots: Research Report No. BR-18920.  Methods
             dated Nov 12, 1973.   (Unpublished study received Jan 4,' 1974 un-
             der 2F1276; submitted by PPG Industries, Inc., Barberton, Ohio;
             CDL:092175-AH)

 00036637 Wledmann, J.L.; Mitten, M.E.; Pensyl, J.W. (1973) Tentative Regula-
             tory Methods for Separating and Determining CIPC and Its Metabo-
             lites in Turnip Tops: Research Report No. BR-18931.  Methods
             dated Nov 29, 1973.   (Unpublished study received Jan 4,  1974 un-
             der 2F1276; submitted by PPG Industries, Inc., Barberton, Ohio;
             CDL:092175-AI)

 00036638 Wledmann, J.L.; Mitten, M.E.; Pensyl, J.W. (1973) Preliminary De-
             termination of CIPC and Metabolites  I, II, III, and IV  in Turnip
             Roots Grown In the Presence of 14C-CIPC at Boyce-Thompson in
             1973: Research Report No. BR-18942.   (Unpublished study  received
            Jan 4, 1974 under 2F1276; submitted  by PPG Industries,  Inc.,
             Barberton, Ohio;  CDL:092175-AJ)

00036639 Wledmann, J.L.; Mitten, M.E.; Pensyl, J.W. (1973) Preliminary De-
             termination of CIPC and Metabolites  I, II, III, and IV  1n Turnip
            Tops Grown In 14C-CIPC Treated Soil  at Boyce-Thompson  during
             1973: Research Report No. BR-18943.   (Unpublished study received
            Jan 4, 1974 under 2F1276; submitted  by PPG  Industries,  Inc.,
            Barberton, Ohio;  CDL:092175-AX)

00036640 WledMnn, J.L.; Mitten, M.E.; Pensyl, J.W.  (1973)  Preliminary  De-
            termination of CIPC and Metabolites  I, II, III,  and IV  1n Or-
            chard Grass Grown in 14C-CIPC Treated Soil at Boyce-Thompson
             during 1973: Research Report No. BR-18957.   (Unpublished study
             received Jan 4, 1974 under 2F1276; submitted by  PPG Industries,
            Inc., Barberton,  Ohio; CDL:092175-AL)
                                         136

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                        OFFICE  OF PESTICIDE PROGRAMS
                     REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered to be Part of the Data Base Supporting
               Registrations Under the Chloropropham  Standard


    MRID            CITATION

 00036641 Wiedmann,  J.L.; Mitten, M.E.; Pensyl, J.W.  (1973) Tentative Regula-
             tory Methods for Separating and Determining CIPC and Its Metabo-
             lites In Orchard Grass: Research Report  No. BR-18946.  Methods
             dated Dec 7, 1973.  (Unpublished study received Jan 4, 1974 un-
             der 2F1276;  submitted by PPG Industries, Inc., Barberton, Ohio;
             CDL:092175-AM)

 00036642 Wiedmann,  J.L.; Mitten, M.E.; Pensyl, J.; et al.  (1973) Analysis of
             1973 Crop Soybean  Plant Samples for CIPC, 2-Hydroxy-5-ch1oroiso-
             propyl  carbanllate, 4-Hydroxy-3-chloro1sopropyl carbanllate, and
             l-Hydroxy-2-1sopropy1-3'-chlorocarbanilate: BTS 18967.- (Unpub-
             lished  study received Jan 4, 1974 under  2F1276; submitted by PPG
             Industries, Inc.,  Barberton, Ohio; CDL:092175-AN)

 00036644 Wiedmann,  J.L.; Krochta, W.G. (1973) Determination of CIPC and Its
             Metabolites In  Soybeans at Fargo, North  Dakota during  1972: Re-
             search  Report No.  BR-18756.  (Unpublished study received Jan 4~,
             1974  under 2F1276;  submitted by PPG Industries, Inc.,  Barberton,
             Ohio; CDL:092175-AG)

00037029  Ware, G.W.; Brake!, W.J. (1963) Excretion of 3-Cl-aniHne and I-
             sopropy1-N-(3-Ch1oropheny1) carbamate (CIPC) 1n the milk and u-
             rine  of dairy cows fed CIPC.  Journal of Dairy Science XLYK2):
            120-123.  (Also 1n  unpublished submission received on  unknown
            date under 4F1429;  submitted by Pittsburgh Plate Glass Co.,
            Morristown, N.J.; CDl:093807-P)

00037031 Gard, L.; Ferguson, C.E. (1972) A Stability Evaluation of CIPC
            Residue  in Treated Soybean Plants and Ladino Clover Resulting
            from Periods of Frozen Storage: Research Report No. BTS-18024.
             (Unpublished study received on unknown date under 4F1429; sub-
            mitted  by Pittsburgh Plate Glass Co., Morris ton, N.J.; COL:
            093807-R)

00037032 Gard, L.; Hledwnn, J.; Mitten, M.E.; et al. (1973)  Tentative
            Regulatory Analytical Methods for Separating  and  Determining
            CIPC and Major Metabolites in Soybean Plants  and  Soybean Seeds:
            Research Report No. BR-18S99.  Methods dated  Jun  4,  1973.
            (Unpublished study received on unknown date under 4F1429;
            submitted by Pittsburgh Plate Glass Co., Morristown,  N.J.;  COL:
            093807-S)
                                        137

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                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
       Citations Considered to be Part of the Data Base Supporting
              Registrations Under the Chloropropham Standard


   MRID            CITATION

00037033 Pensyl, J.;  Mitten,  M.E.; Wiedmann, J.; et al. (1973)  A Gas Chro-
            matographlc Method for the Determination of l-Hydroxy-2-propyl
            3'-chlorocarbanilate (III) and Isopropyl 3-chloro-2-hydroxy-
            carbanilate (IV)  in Soybean Plants and Seeds:  Research  Report
            No. BR-18657.   Method dated Jun 29, 1973.  (Unpublished study
            received on unknown date under 4F1429; submitted by Pittsburgh
            Plate Glass Co., Morristown, N.J.; CDL:093807-T)

00037034 Pittsburgh Plate Glass Company  (19??) Determination of CIPC Residue
            1n Soybean Seeds: Hydroly sis/01stillatlon/Extractlon Colori-
            metric Method:  Research Report No. BTS 17689.  (Unpublished
            study received on unknown  date under 4F1429; CDL:0938d7-U)

00037035 Wiedmann, J.L. (1973) Analysis  of Soybean Shoot Dissipation Study
            Samples for CIPC Residue  and Metabolites  (Isopropyl 5-chloro-2-
            hydroxycarbanllate, Isopropyl  3-chloro-4-hydroxycarbanilate,
            l-hydroxy-2-propyl,3'-chlorocarban11ate):  Research Report
            No. BTS-18626.  (Unpublished study received on  unknown date
            under 4F1429; submitted by Pittsburgh  Plate Glass  Co., Morris-
            town, N.J.; CDL:093807-V)

00037037 Pittsburgh Plate Glass Company (19??) Analytical Method: Determi-
            nation of CIPC Residue  1n Soybean Plants:  (Hydrolysis/01 stilla-
            tlon/Extraction Colorimetrlc Procedure):  Research  Report
            No. BTS-16803.  Undated method.  (Excerpt; unpublished  study re-
            ceived on unknown  date under 4F1429;  CDU093807-Y)

00037038 Wiedmann, J.L. (1973) Analysis of Soybean Seed Samples for CIPC
            Residue and Metabolites (2-OH-CIPC, 4-OH-CIPC,  l-OH-2-propyl
            3'chlorocarban1late:  Research Report No.  BTS-18613.   (Unpub-
            lished study received on unknown date under 4F1429;  submitted by
            Pittsburgh Plate Glass Co., Morristown, N.J.; COL:093807-Z)

00037042 Ferguson, C.E.; Holmes,  A.S.; Gard, L. (1973) Analysis of Soybean
            Seed Samples for CIPC Residue by the Colorimetrlc Method:
            Research Report No. BR-18466.  (Unpublished study received on
            unknown date under 4F1429; submitted by Pittsburgh Plate Glass
            Co., Morristown, N.J.; CDL:093807-AD)

00037043 Ferguson, C.E.; Holmes," A.S.; Gard,  L. (1973) Analysis of Soybean
            Seed Samples for CIPC Residue by  the Colorimetrlc Method:
            Research Report  No. BR-18467.  (Unpublished study received on
            unknown date under 4F1429; submitted by Pittsburgh Plate Glass
            Co., Morristown,.N.J.; CDL:093807-AE)
                                         138

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                        OFFICE OF PESTICIDE PROGRAMS
                     REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered  to be Part of the Data Base Supporting
               Registrations  Under the Chloropropham Standard


    MRID            CITATION

 00037045 Weidmann,  J.L.;  Mitten, M.E.; Pensyl, J.; et al.  (1973) CIPC
             Residue and Metabolite Assay of Two Soybean Seed  Samples and of
             the Seed Fractions Separated from These Samples at the Oilseed
             Crops Laboratory, Peorla, 111.:  Research Report No. BR-18708.
             (Unpublished  study received on unknown date under 4F1429;  sub-
             mitted  by Pittsburgh Plate Glass Co.,  Morristown, N.J.; CDL:
             098307-AH)

 00037046 Mitten,  M.E.  (1973) A Gas Chromatographic Method for the Deter-
             mination  of CIPC 1n Soybean Seeds: Research Report No. BR-18747.
             (Unpublished  study received on unknown date under 4F1429;  sub-
             mitted  by Pittsburgh Plate Glass Co.,  Morristown, N.J.; CDL:
             093807-AI)

 00037285 Wledmann,  J.L.;  Mattle, O.M.; Chandler, C.M.;  et al. (1976) CIPC
             and PPG-124 Residues in Yuchi Arrow!eaf Clover, 1976 Crop:  BTS
             20352.   (Unpublished study received Sep 21, 1976  under 748-161;
             submitted  by  PPG Industries, Inc., Barberton, Ohio; CDL:
             095292-AG)

 00037860 Ecke,  G.G.  (1973) Agricultural Chemicals. CCXL and CCCL:  CIPC
             Metabolites in Turnips: Research Report No. BR-18407.   (Unpub-
             lished  study  received Jan 4, 1974 under 2F1276;  submitted  by PPG
             Industries, Inc., Barberton, Ohio; CDL:092175-M)

 00037861  Ecke, G.G. (1973) Synthesis of glucosides of Isopropyl 3-chlorocar-
             banllate metabolites.  Journal  of Agricultural  and Food Chemis-
             try 21(5):792-794.  (Also in unpublished submission received Jan
             4, 1974 under 2F1276; submitted by PPG Industries, Inc., Barber-
             ton, Ohio; COL:092175-N)

00037863 Ferguson,  C.E.; Holmes, A.S.; Gard, L. (1973)  Analytical  Method and
             Analysis of 14C Labeled CIPC Treated Turnip Plants and Roots for
             Unaltered CIPC Residue: Research Report No. BTS-18390.  Method
             dated Feb 12, 1973.  (Unpublished study received Jan 4,  1974 un-
             der 2F1 2 76; submitted by PPG Industries, Inc., Barberton,  Ohio;
             CDL:092175-P)

00037866 Gard, L.;  Holmes, S. (1973) Analysis of 14C-CIPC (Ring-Labeled)
             Treated Turnip Tops and Roots for Unaltered CIPC Residue  by the
            Colorimetric Method: Research Report No. BTS-18523.  (Unpub-
             lished  study  received Jan 4, 1974 under 2F1276;  submitted by PPG
             Industries, Inc., Barberton, Ohio; CDL:092175-S)
                                          139

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                        OFFICE OF PESTICIDE PROGRAMS
                     REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered  to be Part of the Data Base Supporting
               Registrations  Under the Chloroprophara Standard
   MRID            CITATION

00037881 Jensen,  D.J.; Miller, P.W.  (1973) Studies To Determine Possible
            Bound Residues of 6-Chloropicolinic acid (6-CPA) in Wheat: GH-C
            655.  (Unpublished study received Jun 6, 1973 under 2F1265; sub-
            mitted  by Dow Chemical U.S.A., Midland, Mich.; CDL:092164-P)

00039946 Ercegovich, C.D.; Witkonton, S.  (1972) An improved method for the
            analysis of residues of  Isopropyl N-(3-chlorophenyl)carbamate
            (Chlorpropham) in alfalfa.  Journal of Agricultural an4 Food
            Chemistry 20(2):344-347.  (Also in unpublished submission re-
            ceived  Feb 24, 1977 under 748-161; submitted by PPG Industries,
            Inc., Barberton, Ohio; CDL:096029-B)

00045294 PPG  Industries, Incorporated (1969) General Analytical Method for
            Determining CIPC Residues in  Crops Designated in the Summary  .
            Table as Being Analyzed  by MF (Ext.).  (Unpublished study re-
            ceived  Dec 31, 1970 under 1F1119; CDL:093430-D)

00045295 PPG  Industries, Incorporated (1968) General Analytical Method for
          -  Determining CIPC Residues in  Crops Designated in the Summary
            Table as Being Analyzed  by the MF (TCH-Dist) Method.   (Unpub-
            lished  study received Dec 31,  1970 under 1F1119; CDL.-093430-E)

00051807 Ferguson,  C.E. (1967) Analysis of Harvested Blackberries  for Resi-
            dues  of the Herbicide CIPC: Research Report No. BTS-14867.  (Un-
            published study received on unknown date under 1F1119; submitted
            by PPG  Industries, Inc., Barberton, Ohio; CDL:090890-B)

00051812 Ferguson,  C.E. (1968) Analysis of Dried Southern Peas for Residues
            of CIPC: Research Report No.  BTS-15245.  (Unpublished  study re-
            ceived  on unknown date under  1F1119; submitted by PPG  Indus-
            tries,  Inc., Barberton,  Ohio;  CDL.-090890-C)

00051814 Ferguson,  C.E. (1968) Analysis of Soybeans for Residues of CIPC:
            Research Report No. BTS-15132.   (Unpublished study received on
            unknown date under 1F1119; submitted by PPG Industries, Inc.,
            Barberton, Ohio; CDL.-090890-I)
                                          140

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                        OFFICE OF PESTICIDE PROGRAMS
                     REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered  to be Part of the Data Base Supporting
               Registrations  Under the Chloropropham  Standard


    MRID            CITATION

 00051815 Mitten,  M.E.;  Paul 1 In, J. (1970) Analysis of Treated Soybean Sam-
             ples  from the University of Minnesota for CIPC  Residue: Research
             Report No.  BTS-16278.  (Unpublished study received  on unknown
             date  under  1F1119; submitted by PPG Industries, Inc., Barberton,
             Ohio;  CDL:090890-J)

 00051817 Ferguson,  C.E.; Mitten, M.E. (1970) Analysis of Treated Soybean
             Samples  from the University of Arkansas  for CIPC Residue: Re-
             search Report No. BTS-16280.  (Unpublished  study received on un-
             known  date under 1F1119;  submitted by PPG Industries, Inc., Bar-
             berton, Ohio; CDL:090890-M)

00051822  Ferguson, C.E.; Gard, L. (1970) Analysis of Lima Beans for CIPC
             Residue: Samples Grown in California: Research  Report No. BTS-
             16488.   (Unpublished study received on unknown  date under
             1F1119;  submitted by PPG Industries, Inc.,  Barberton, Ohio; COL:
             090890-U)

00051824  Ferguson,  C.E.; Holmes, A.S.; Gard, L. (1970)  Analysis of  Sugar
             Beet Tops and Roots for CIPC Residue, and Roots Only  for I PC
             Residue: Samples Grown 1n California: Research  Report No.  BTS-
             16633.   (Unpublished study received on unknown  date under
             1F1119;  submitted by PPG Industries, Inc.,  Barberton,  Ohio; CDL:
             090890-W)

00051834  Ferguson,  C.E.; Gard, L. (1970) Analysis of Garlic Bulbs for CIPC
             Residue: Research Report No. BTS-16432.  (Unpublished study in-
             cluding letter dated Oct 21, 1970  from H. Agamalian to Warren
             H. Zlck, received on unknown date  under  1F1119; submitted by
             PPG  Industries,  Inc., Barberton, Ohio; COL:090890-AG)

00051838  Ferguson,  C.E.; Holmes, A.S.  (1969) Analysis of Tomatoes for CIPC
             Residues: Research Report  No. BTS-16198.   (Unpublished study
             received on unknown date under  1F1119;  submitted by PPG  Indus-
             tries,  Inc., Barberton, Ohio; CD L: 090890- AK)

00051845  Ferguson,  C.E.; Miller, 0.; Gard,  L.  (1970) Analysis  of Red Clover
             Samples for CIPC Residue:  Research Report  No.  BTS-16666.  (Un-
             published study  received on  unknown date under 1F1119; submit-
             ted  by PPG  Industries, Inc., Barberton,  Ohio;  COL:090890-AS)
                                       141

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                        OFFICE  OF PESTICIDE PROGRAMS
                     REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered  to be Part of the Data Base Supporting
               Registrations  Under the Chloropropham  Standard


    MRID            CITATION

 00051851 Ferguson,  C.E.; Miller, D.; Card, I.; et al.  (1970) Analysis of
             Alfalfa Samples  for CIPC Residue:  Research Report No. BTS-16657.
             (Unpublished study received on unknown date under 1F1119; pre-
             pared 1n cooperation with Univ. of California--Davis, Botany
             Dept.  and Baker  Brothers, submitted by PPG Industries, Inc.,
             Barberton,  Ohio; CDL:090890-AY)

 00051852 Wlnterlin,  W.; Archer, T.E. (1969) Determination of CIPC Residue
             in Alfalfa  (HydroIysis/D1stillat1on/Extraction Colorimetrlc
             Method.  (Unpublished study including ag.  tox. nos. 651 and 376,
             received on unknown date under 1F1119; prepared in cooperation
             with Univ.  of Cal1fornia--Davis,  submitted by PPG Industries,
             Inc., Barberton, Ohio; CDL:090890-AZ)

 00051853 Ferguson, C.E.; Gard, I. (1970)  Analysis of Alfalfa Samples  for
             CIPC  Residue:  Research Report No.  BTS-16804.  (Unpublished study
             received on unknown date under 1F1119; submitted by PPG  Indus-
             tries, Inc., Barberton, Ohio;  CDL:090890-BA)

 00051854  Ferguson, C.E.; Miller,  D.; Gard, L.  (1970) Analysis of Alfalfa
             Samples  for CIPC Residue: Research Report No. BTS-16664.  (Un-
             published study received on unknown date under 1F1119; submit-
             ted by PPG  Industries, Inc.,  Barberton,  Ohio; CDL:090890-BB)

 00051855  Ferguson, C.E.; Miller,  D.; Gard, L.  (1970) Analysis of Alfalfa
             Samples  for CIPC Residue: Research Report  No. BTS-16665.  (Un-
             published study received on unknown date under 1F1119; submit-
             ted by PPG  Industries, Inc.,  Barberton,  Ohio; CDL:090890-BC)

00051856  Ferguson, C.E.; Miller,  D.; Gard, L.  (1970) Analytical Method  and
             Results  for CIPC Dissipation  from Grasses  (Tall Fescue and Or-
             chard Grass):  Barberton Report No. BTS-16776.   (Unpublished
             study received on. unknown date under 1F1119;  submitted  by PPG
             Industries, Inc., Barberton,  Ohio; CDL:090890-BD)

00051861  Ferguson, C.E. (1968) Analysis of Treated Cranberries  for Residues
             of CIPC: Research Report No.  BTS-15107.  (Unpublished study
             received on unknown date under 1F1119; submitted by PPG  Indus-
             tries, Inc., Barberton, Ohio; COL:090890-BI)

00054669  Ware, G.H.; Brakel, H.J. (1963) Excretion of 3-Cl-an1l1ne and Iso-
             propyl-N-(3-chlorophenyl) carbamate (CIPC) In the milk and urine
             of dairy cows fed CIPC.  Journal  of Dairy Science 46:120-123.
             (Also in unpublished submission received Aug 26, 1977 under
             4581-EX-30; submitted by Pennwal t Corp., Philadelphia, Pa.; GDI:
             231831-1)


                                         142

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                        OFFICE OF PESTICIDE PROGRAMS
                     REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered to  be Part of the Data Base Supporting
               Registrations Under the Chloropropham Standard


    MRID            CITATION

 00054672 Dave,  B. (1977)  Residue Data of CIPC on Potatoes.  (Unpublished
             study received  Aug 26, 1977 under 4581-EX-30; submitted by Penn-
             waltCorp., Philadelphia, Pa.; CDL:231831-T)

 00058143 Norrls,  J.M.;  L1tchf1eld, N.; Dunn, F.L. (1969) Progress Report on
             the Toxlcologlcal Studies Being Conducted on Premerge 21
             Weed  Killer (M-3497).  (Unpublished study received Nov 21, 1969
             under 264-256;  prepared by Dow Chemical Co.,  submitted by Union
             Carbide Agricultural Products Co., Inc., Ambler, Pa.; CDL:
             002219-B)
                                                                *

 00058147 Raman, H.P.  (1969)  Tentative Method for the Determination of Ami ben
             1n Anrfben-ONBP  Liquid Formulations (Amchem 69-304).  (Unpub-
             lished study  received Nov 21, 1969 under 264-256; submitted by
             Union Carbide Agricultural Products Co., Inc., Ambler, Pa.; COL:
             002219-H)

 00083155 Gard, L.N.  (1959)  Determination of isopropy! N-(3-chlorophenyl)
             carbamate residues 1n potatoes treated for sprout Inhibition.
             Journal  of Agricultural and Food Chemistry 7(5):339-341.   (Also
             In unpublished  submission received Dec 1, 1959  under PP0234;
             submitted by  Columbia-Southern Chemical Corp.,  Pittsburgh, Pa.;
             COL:090262-G)

 00083158 Gard, L.N.; Pray,  B.O.; Rudd, N.G. (1954) Residues 1n  crops  receiv-
             ing pre-emergence treatment with Isopropyl  N-(3-ch1oropheny1)
             carbamate.  Journal of Agricultural and Food Chemistry 2(23):
             1174-1176.  (Also 1n unpublished submission received Dec  1,  1959
             under PP0234; submitted by Columbia-Sou them Chemical Corp.,
             Pittsburgh, Pa.; COL:090262-J)

00083334  PPG Industries,  Incorporated (1963) Residue of CIPC  on Sweetpota-
             toes.   Includes method no. BTS-11350 dated Jun 12,  1962.   (Com-
             pilation; unpublished study received Nov 21, 1965 under PP0409;
             CDL:090441-B)

00093915  Ross, D.B.; Roberts, N.L.; Phillips, C.N.K.; et al.  (1980)  The
             Acute Oral Toxldty (LD50) and the Neurotoxlc Effects  of CIPC
             on the Domestic Hen: PPG 4 NT/80188.   (Unpublished study re-
             ceived Jan 25,  1982 under 748-161; prepared by Huntingdon Re-
             search Centre,  England, submitted by PPG Industries, Inc.,
             Barberton, Ohio; COL:246648-A)
                                       143

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                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered to be Part of the Data Base Supporting
               Registrations Under the Chloropropham Standard


    MRID            CITATION

 00093921 Rodwell, D.E.; Krabbe, R.; Werchowskl,  K.M.  (1981) A Teratology
             Study  in  Rats with CIPC: WIL-81107.   (Unpublished study received
             Jan 25, 1982 under 748-161; prepared by WIL  Research Laborato-
             ries,  Inc., submitted by PPG Industries,  Inc., Barberton, Ohio;
             CDL:246650-A)

 00094865 Pensyl, J. (1982) Characterization of CIPC Residues  in Cured To-
             bacco  Field Treated with 14C-PPG-575:  BR  22524.   (Unpublished
             study  received Feb 11, 1982 under. 748-233; submitted by PPG
             Industries, Inc., Barberton, Ohio; CDL:246815-B)

 00094866 Pensyl, J. (1982) Characterization of CIPC Residues  in Smoke from
             Cigarettes Spiked with 14C-labelled CIPC: BR 22531.  (Unpub-
             lished  study received Feb 11, 1982 under  748-233; submitted by
             PPG  Industries, Inc., Barberton, Ohio; CDL:246815-C)

 00094867 Pensyl, J. (1982) Characterization of CIPC Residues  in Smoke from
             Cigarettes Manufactured with Carbon-14 Labeled PPG-575 Field  -
             Treated Tobacco: BR 22542.  (Unpublished  study received Feb
             11,  1982  under 748-233; submitted by PPG  Industries, Inc.,
             Barberton, Ohio; CDL:246815-0)

 00106293 Uniroyal Chemical (1971) Alanap and Other Insecticide Residues in
             Cranberries and Soybeans.  (Compilation;  unpublished  study
             received  on unknown date under 400-85; COL:023355-A)

 00114695 Fredenburg,  R. (1960) Letter sent to E. Plant dated Nov 8, 1960:
             Emulslflable sprout nip: Chloro-IPC.  (Unpublished study re-
             ceived  Feb 14, 1961 under 748-182; submitted by PPG  Industries,
             Inc., Barberton, OH; 0)1:024269-8)

 00114700 Kennedy, G.; Jenkins, 0. (1970) Report to PPG Industries, Inc.:
             Distribution of CIPC 1n Milk and Tissues of a Lactatlng Cow:  IBT
             No. J8629A.  (Unpublished study received on unknown  date under
             1F1119; prepared by Industrial Bib-Test Laboratories, Inc.,
             submitted by PPG Industries, Inc., Barberton, OH; CDL:090892-I)

00114701 Kennedy, G.  (1970) Report to PPG Industries, Inc.: Tissue and Egg
             Residue Study of CIPC in White Leghorn Chickens: IBT No. J8630A.
             (Unpublished study received on unknown date under 1F1119;  pre-
             pared by  Industrial B1o-Test Laboratories, Inc., submitted by
             PPG  Industries, Inc., Barberton, OH; CDL:090892-J)

00114710.Pittsburgh Plate Glass (1967) Study: CIPC Residue on Selected
             Crops.  (Compilation; unpublished study received Aug 23, 1967
             under 8F0690; COL:091198-A)
                                       144

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                        OFFICE OF PESTICIDE PROGRAMS
                     REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered to be Part of the Data Base Supporting
               Registrations Under the Chloropropham Standard


    MRID            CITATION

 00114715 PPG Industries,  Inc.  (1972) Petition of PPG Industries, Inc. Pur-
             suant to Section 408 (d)(l) of the Federal  Food, Drug and
             Cosmetic Act with Respect to the Pesticide  Chemical Chlorpro-
             pham.   (Compilation; unpublished study received Jun 1, 1972
             under 2F1276; CDL:092107-A)

 00114717 Anon.  (1972) Determination of CIPC Residues in Soybeans.  (Compi-
             lation;  unpublished study received Nov 20,  1972 under 3G1311;
             submitted by ?;  COL:092241-A)

 00114718 Columbia-Southern Chemical Corp.  (1960) Analyses for Residues of
             CIPC and Other Chemicals in Potatoes.  (Compilation; unpub-
             lished study received on unknown date under PP0234; COL:
             092511-A)

 00114725 PPG Industries, Inc.  (1977) Results of Tests on  the Nature  and
             Amount of Residue: PPG-124.  (Compilation;  unpublished study   .
             received Jun 9,  1977 under 7F1963; CDL:096152-A; 096153)

 00114729 Ecke, G.; Pensyl, 0.  (1978) Hydrolysis of Isopropyl 3-Chlorocarban-
             ilate  (CIPC): BR 20955.  (Unpublished study received Feb 3, 1978
             under 748-161; submitted by PPG Industries, Inc., Barberton, OH;
             CDL:096789-B)

 00114737 PPG Industries, Inc.  (1978) PPG-124 Residues 1n  Plants.  (Compila-
             tion;  unpublished study received Nov 15, 1978 under 7F1963; CDL:
            097609-B)

00114739 PPG Industries, Inc.  (1974) Analyses for Residues of CIPC
             Chemicals 1n Various Products.  (Compilation; unpublished study
             received on unknown date under 4F1429; CDL:098173-A)

00114740 Pittsburgh  Plate Glass Co. (1965) Analyses for Residues  of CIPC:
             in Sweet Potatoes.  (Compilation; unpublished study received on
             unknown  date under PP0409; CDL-.098548-A)

00114741 Columbia  Southern Chemical Corp. (1960) Analyses for Residues of
             CIPC Chemicals 1n  Potatoes.  (Compilation;  unpublished
             study  received on  unknown date under PP0234;  COL-.098745-A)

00114743 PPG  Industries, Inc.  (1970) Study: CIPC Residue on Soybeans.
             (Compilation; unpublished study received Dec 16, 1970 under 748-
            161; CDL:101498-A)

00114747 PPG  Industries, Inc.  (1961) Analyses for Residues of CIPC 1n
            Potatoes.  (Compilation; unpublished study received Mar 17,
            1961 under unknown admin, no.; COL-.120933-A)


                                    145

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                       OFFICE OF PESTICIDE PROGRAMS
                    REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered to be Part of the Data Base Supporting
               Registrations Under the Chloropropham Standard


    MRID           CITATION

 00114748  Freed, V. (1962) Analyses for Residues  of CIPC 1n Cranberries.
             (Compilation; unpublished study  received Mar 2, 1962;  Mar 19,
             1962 under unknown admin, no.;  submitted by ?; CDL:120934-A)

 00114750  Food  Machinery and Chemical  Corp.  (1956) Sprout Control  in Irish
             Potatoes.  (Unpublished study received on unknown date under
             unknown admin, no.; CDL:120940-A)

 00114751  Gard, L. (1957?) Determination of  ... (CIPC) Residues in Potatoes
             Treated for Sprout Inhibition.   (Unpublished study received Nov
             24, 1958 under unknown admin, no.; submitted by PPG Industries,
             Inc., Barberton, OH; CDL:120941-A)

 00114777 Agchem (1978) Analyses for Residues of  CIPC in Potatoes.  (Com-
            pilation; unpublished study received Aug 14, 1978 under 4581-EX-
            30; CDL:234638-A)

00114778 PPG Industries,  Inc. (1978)  Analyses  for Residues  of Furloe
            Chloro I PC 4EC and Furloe Chi or o I PC 10G in Soybeans.  (Compi-
            lation; unpublished study received Sep 13, 1978 under 748-161;
            COL:235138-A)

00114785 Agchen (1978) Residue Data of CIPC  on Potatoes.   (Compilation; un-
            published study received Nov 21, 1978 under 4581-338; COL:
            235995-G)

00114794 PPG Industries,  Inc. (1979)  Analyses  for Residues  of Furloe 124
            and Other Herbicides In Various Products.   (Compilation; unpub-
            lished study received Jun 13,  1979 under 748-220; CDU238627-A)

00114795 PPG Industries, Inc. (1979)  Summary of 1978-1979  Tests Using Decco
            Brand CIPC-AR under EPA Permit I4581-EUP-30.   (Compilation; un-
            published study received Jul 18, 1979  under 4581-EX-30;  COL:
            238857-A)

00115388 PPG Industries, Inc. (1967) CIPC:   Residues In M1lk and Other
            Subjects.  (Compilation; unpublished study received on unknown
            date under 1F1120; COL:090894-A)

00126737 Henry, C.; Dansle, 0. (1983) Study of the Toxldty of CIPC Derived
            Residues 1n Tobacco Smoke Administered to Mice for 21 Days: Ex-
             periment No.  1-1727.005.   Final rept.  (Unpublished study re-
             ceived Apr 11, 1983 under  748-233;  prepared by Microbiological
            Assoc., submitted by PPG Industries, Inc., Barberton, OH;
            CDL:249884-A)
                                         146

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                        OFFICE OF PESTICIDE  PROGRAMS
                     REGISTRATION STANDARD BIBLIOGRAPHY
        Citations Considered to be Part  of the Data Base Supporting
               Registrations Under the Chloropropham Standard


    MRID            CITATION

 00129545 Schroeder, R.;  Daly, I.; Hogan,  G.; et al. (1983) A Two Generation
             Reproduction Study In Rats  with CIPC: Project No. 81-2573.  Fi-
             nal rept.   (Unpublished  study received Jul 19, 1983 under 748-
             161; prepared by Bio/dynamics,  Inc., submitted by PPG Indus-
             tries,  Inc., Bareberton, OH;  CDL:250764-A; 250765; 250766)

 00129938 Kirby, P.; Pizzarello, R.;  Rogers, A.; et al. (1983) L5178Y/TK+/-
             Mouse Lynphoma Mutagenesis  Assay: ... Test Article CIPC, Isopro-
             pyl 3-Chlorocarbanilate: Study  no. T1890.701.  (Unpublished
             study received Jul 26,  1983 under 748-161; prepared by'Micro-
             biological  Assoc., submitted  by PPG Industries, Inc., Barberton,
             OH; CDL:250808-A)

 00129940 James, P.; Billington, R.;  Clark,  R.; et al. (1983) A study of the
             Effect  of CIPC on Pregancy  of the Rabbit: HRC Report No. PPG
             5&7/832S.   (Unpublished  study received Jul 26, 1983 under 748- .
             161;  prepared by Huntingdon Research Centre, Eng., submitted by
             PPG Industries, Inc., Barberton, OH; CDL:250809-C)

 00139860 Rohm & Haas Company (1966)  Determination of Microquantities of Stam
             F-34  in Plant Tissues.   Rev.  Method dated May 12, 1966.  (Un-
             published studY 2eceived Mar  2, 1977 under 707-EX-88; CDL:
             228160-D)

 05016141  Ebing, tf.  (1972) Routinemethode  zur
             Duennschichtchromatographischen Identifizierung der
             Pestizidrueckstaende aus den  Klassen der Triazine-, Carbamate,
             Harnstoffe und Uracile Routine  method for identification of
             pesticide residues of trlazlne, carbamate', urea,  and uracil
             type  compounds by thin-layer  chromatography Journal of
             Chromatography 65(3):533-545.

40208603  PPG Industries, Inc. (1987) Acute  Toxicity of Chlorpropham to
             Bluegill Suafish (Lcpomls macrochirus).   (ABC  Study No. 35418
             conducted by ABC Laboratories,  Inc.)

40208604 PPG  Industries, Inc. (1987) Acute  Toxicity of Chlorpropham (CIPC
             Technical) to Rainbow Trout (Salmo  galrdneri).   (ABC  Final
             Report  No. 35419 conducted  by ABC Laboratories,  Inc.)

40378101 Prendeville, G.; Eshel, Y.; James, C.;  et  al.  (1968) Movement  and
            metabolism of CIPC In resistant and  susceptible  species.   Weed
             Science  16(4):432-435.

40378102 James, C.;  Prendeville, G.  (1969)  Metabolism of Chlorpropham (Iso-
             propyl  m-Chloroca'rbanllate) in  various  plant species.  Agricul-
            tural and Food Chemistry 17(6):1257-1260.

                                       147

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     APPENDIX V



       FORMS
- 147-A -

-------
                                                                          out
                                                                                  Mo.
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      O I. .1 «*l mjbmft Am in i iim«4» m«nn«r 10 •iaf y in* r not
           tp«ct(itd inl AM fl^sintiod C«td*im«i or m* Protocol content* m ffl« Nofant of €SM«I Group* to Clio CAtaicate C/ouo. OECO
           ChonieaH T«imf Proartmmo. I onctooi m* groiocoit tn*t I will u»:
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                                                                        3IO(2>(IHa n
   NAMC O^ OTHER
     Q1 I ofldMi • eomottiM •C*rtrlie«oion ol Antmpt to Enttr Into on Afroommt wtft Olnor Hoiiiuniu (or 0
          roptct to HM I oMomiM dta nqwirtmonti:
C 4. I r»n«n Bin you omoM «v rafioMMn oy MofMf
                                                            un (m« o»u«* • wt IM^OM» it OMteinti lor ntw oroducti):
    Oil!
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                                                                                                   OAT«
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                                                            148

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          . art* ^LL lour inmt
                                                  .    i ATTEMPT TO CNTIlt
                                 INTO AN AOMEMtNTWfTM OTHCM MCOKTIUNT8
                                          fOII OCVtLOPMEMT Of DATA
I. I am duty awWoriMd to rapratant 0M fotiowina firmfe) wAo ara autojaet to «M
  mams of a NotJe* under f «f HA Saction 3(e)(2)(8) eontainad in aGuidanea O«
  to auomit data oanojminf mt aetiv* inoraditnt:
                                                                              ACTIV*
 Th«t firm or youo o< «.rm« « f«>«rr«d to b»(Ow tt ~mr firm'M
Z My fwm •» willw^ 10 d***too ind memn tn« d«u «t rtquntd by ftwt Notice. M nvenufy. Monnnr. my lirm would erf*** to e«i*>
  into «n «o/««ni«nt witn onr or more otlttr rcqitiranti to d«««toO jointly, or to ««•»• in tftt cod ol dr*«4oo>n9. tne to"owinf tenu-tra
  Htmtot data:
 My Km (MI ofttftd in urnm) to tmt« MM me* M ay»jin«nt CMM •< M* «N«n art titatiMtf. T.tat tHir «w irrtvociM* tM inciuotd tn oH* to at
 Bound by an arMratiM 4ttm*t> vndar Flf MA Sottio* ](cJ(2J(ll(nU i> 
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EPA Reg.  No.
PRODUCT SPECIFIC DATA REPORT



            Date
Registration Standard for
Registration
Guideline No.
S 158. 120
PRODUCT
CHEMISTRY
61-1
61-2
61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-10
63-11
63-12
Name of Test

Identity of
ingredients
Statement of
composition
Discussion of
formation of
ingredients
Preliminary
analysis
Certification of
limits
Analytical methods
for enforcement
limits
Color
Physical state
Odor
Melting point
Boiling, point
Density, bulk-
density, or
specific gravity
Solubility
Vapor pressure
Dissociation
constant
Octanol/water
partition
coefficient
pH
Test not
required
for my
product
listed
above
(check
below)


















I am complying with
data requirements by
Citing MRID
Number or
EPA Accession
Number


















Submit-
ting
Data
(At-
tached)


















(For EPA Use Only)
HRID Numbers
Assigned



-














                                       150

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Registration
Guideline No.
63-13
63-14
63-15
63-16
63-17
63-18
63-19
63-20
63-21
S 1.58. 135
TOXICOLOGY
81-1
81-2
81-3
81-4
81-5
81-6
Name of Test
Stability
Oxidizing/reducing
reaction
Flammability
Explodability
Storage stability
Viscosity
Miscibility
Corros ion
characteristics
Dielectric break-
down voltage

Acute oral
coxicity, rat
Acute dermal
toxicity, rabbit
Acute inhalation,
toxicity, rat
Primary eye
irritation, rabbit
Primary dermal
irritation
Dermal sensitiza-
tion
Test not
required
for my
product
listed
above
(check
below)
















I am complying with
data requirements by
Citing HRID
Nunber or
EPA Accession
Number
















Submit-
ting
Data
(At-
tached)
















(For EPA Use Only)
MR ID Numbers ,
Assigned




*











151

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                                             CUB Approval No. 2070-0057
                                             Expiration Date 11/30/89
                          GENERIC DATA EXEMPTION STATEMENT

 EPA Product Registration Number: 	

 Registrant's Name and Address:   	
     As an authorized representative of the registrant of the product identified
 above, I certify that:

     (1)  I have read and am familiar with the terms of the Notice from EPA dated
               concerning a requirement for submission of generic data on the
 active ingredient	named under FIFRA Section 3(c)(2)(B).

     (2)   Ity firm requests  that EPA not suspend the registration of our product,
 despite our lack of intent to submit  the generic data in question, on the grounds
 that the product contains  the active  ingredient solely as the result of the
 incorporation into  the product of another product which contains that active
 ingredient,  which is registered under FIFRA Section 3, and which is purchased by
 us from another producer.

     (3)   An accurate Confidental  Statement of Formula(CSF) for the above-identified
 product  is  attached to this statement.  That formula statement indicates, by
 company name,  registration number, and product name, the source of the subject
 active ingredient in my firm's product, or

 The CSF dated            on file  with EPA is complete, current and accurate and
 contains the information requested on the current CSF Form No. 8570-4.  The
 registered  source(s)  of the above named active ingredient in my product(s) is/are
 	 and their registration number(s) is/are 	

     (4)  My  firm will apply for an amendment to the registration prior  to changing
 the source of  the active ingredient in our product to one that is not  registered
 and purchased.

     (5)   I understand,  and agree  on behalf of my firm, that  if at any  tine any
 portion  of this Statement  is no longer true, or if my firm fails to comply with
 the undertakings made in this Statement, my firm's product's registration may be
 suspended under FIFRA Section 3(c)(2)(B).

     (6)   I further  understand that if my firm is granted a generic data exemption
 for  the  product,  my firm relies on the efforts of other persons  to provide the
Agency with  die required generic  data.  If the registrant(s) who have committed
 to generate  and submit the required data fail to take appropriate steps to meet
 requirements or are no longer in  compliance with this Notice's data  requirements,.
 the Agency will consider that both they and my firm are not  in compliance and
will normally  initiate proceedings to suspend the  registrations  of my firm's
 product(s) and  their product(s),  unless my firm commits  to  submit and submits
 the  required data in the specified tine frame.   I understand that,  in such cases,
 the Agency generally will  not grant a time extension  for submitting the data.

 Registrant's authorized representative:	          	
                                               (Signature)

Dated:	                 '	
                                   j 52         (Typed)                '

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