\
m
CO
Chemicals Identified In
Human Biological Media,
A Data Base
Second Annual Report
October 1980
-------
Printed in the United States of America. Available from
National Technical Information Service
U.S. Department of Commerce
5285 Port Royal Road. Springfield, Virginia 22161
NTIS price codes—Printed Copy: A22 Microfiche A01
This report was prepared under contract to an agency of the United States Government.
Neither the United States Government nor any of their employees, contractors,
subcontractors, or their employees, makes any warranty, express or implied, nor assumes
any legal liability or responsibility for any third party's use o;- the results of such use of any
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use by such third party would not infringe privately owned rights.
Publication of the duta in this document does not signify that the contents necessarily re licet
the joint or separate views and policies of each sponsoring agency. Mention of trade names
or commercial products does not constitute endorsement or recommendation for use.
-------
EPA 560/13-80-036B
ORNL/EIS-163/V2-P2
CHEMICALS IDENTIFIED IN HUMAN BIOLOGICAL MEDIA,
A DATA BASE
Second Annual Report, October 1980
Volume II, Part 2
Records 1581-3500
Compiled by
M. Virginia Cone, Margaret F. Baldauf,
Fay M. Martin, and John T. Ensminger
Health and Environmental Studies Program
Information Center Complex/Information Division
OAK RIDGE NATIONAL LABORATORY
Oak Ridge, Tennessee 37830
operated by
UNION CARBIDE CORPORATION
for the
DEPARTMENT OF ENERGY
Contract No. W-7405-eng-26
This effort was accomplished under the aegis
of the Interagency Collaborative Group on
Environmental Carcinogenesis, National Cancer
Institute, National Institutes of Health,
Chairperson, Dr. Herman F. Kraybill.
Date Published - January 1981
Cindy Stroup, Project Officer
Design and Development Branch
Exposure Evaluation Division
Office of Pesticides and
Toxic Substances
U.S. Environmental Protection Agency
Washington, D.C. 20460
-------
CONTENTS
Part 1
Acknowledgments v
Introduction 1
Users' Guide 3
Abbreviations for Analytical Methods 7
References for Data Base 9
References for Physical and Chemical Data 87
Appendix A. Journals Searched 91
Appendix B. Chemicals in Data Base (by CAS Registry Numbers
and Preferred Names) 97
Appendix C. Cross-Referenced Chemical Lists 121
1. CAS Preferred Names — Common Names 123
2. Common Names — CAS Preferred Names 163
Appendix D. Tissues and Body Fluids in Data Base 387
Cumulative Indices, 1979-1980 391
Author 393
Corporate Author 423
Tissue 453
Keyword 457
Directory of Chemicals 469
CAS Preferred Names 471
Formulas 485
Part 2
Data Base 1
iii
-------
(1.3)Dloiolo(«,S-g)clnioline-3-cacboxyllc tcU. 1-ethrl-1.»-dihyaro-a-oxo-
28657-80-9
C12-B10-112-05
» 262.2«
TTSSVI
1581
Blood.
seraa
1582
Oei«e
EXPOSURE ROUTE
Injection
Injection
1I1LTTIC1L
BBTBOD
Plaocaeetry
flaocoeetcy
•DBBEI
OF C1SBS
9
9
I1IGE
•1 2.0-0.03 09/1!
b) 3.6-0.03 og/al
c) 11.6-0.09 ag/il
d) 30.2-0.1 09/»1
•1 19-25 19
b) 59-70 19
c) 88-126 19
4) 222-323 19
, .
mi
•) tot applicable
b) lot applicable
c) lot applicable
d) lot applicable
a| lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
OlltUt XBPOBB1TXOB
a) 0.25 and a ar, 50-»g dose, a
•objects
b| 0.25 and 8 he. 100-19 «<>«•. a
(Objects
c) 0.25 and 8 he. 250-ag dose. 9
•ibjects
d| 0.25 and 8 br. 500-19 dole. 5
Mbject*
*al«e« ace >ean« after 10-eln
infulone. Ul showed
aoaoaxpoaential decar- 500 ig
pcobenecld 6 and 12 he before
iifoiion of 250 19/hr clnozadn
Incceaied steady state blood lerals
501.
Baaltar aales. aoea 21-55 yc. on a
coatcolled hospital diet.
1ITIBIOTICS; OEOOSj DIN TIEllPI;
BLOOD SEIOB; ZIDItlti OKIBJ
COaPHlTITB BTILOtTIOIS
a) 50-19 dose, a sabjects
b) 100-19 dose, a subjects
c) 250-«9 dose. 9 subjects
d) 500-19 dose, 5 subjects
Talues ace 2- and 2»-hr cuMlatlve
oclaes after 10-aln lafusloia.
tcobenecld pce-tceataent decnased
••out in 6-hc acinea by 25X.
Bealthy (ales, ages 21-55 yc. on •
contcolled hospital diet.
11TIBIOTICS; DIOOS; DlOa THEUPT;
HOOD SBIOH; IIDItlt; MI IE!
CORPMITITB BflLOHIOIS
IBFBIEICB
Israel, K.s.
Black, B.I.
•elsoi, l.l.
BCUISOB, B.K.
lash, J.r.
Bclec, e.L.
lolney. J.D.
1918
Iscael, 1.3.
Black, B.I.
lelsoa, B.L.
Bcuison, B. K.
lash. j.r.
Bclec. 0.1.
lolney, J.D.
1978
-------
icataiU*. B-(S-«alfanarl-1.3t«-thladlaTol-2-rl)- (8 CI)
IcettaUa, B-(5-(»eino««lfonill-'.3.«-thi«dtMol-2-Tll- (9 Ct)
59-S6-S
C»-«6-I«-03-S2
BI 222.25, HP 2S8-2S9 C («ff etmcea)
TISSOB
1583
Wood.
plain
CXfOSmi BOOTS
Ingest Ion
mi
tuinicii
BETBOD
RFLC
IOBBB1
OF CISBS
1
MMB
.
a) 16.0-0.63 og/il
b) 13-1.7 09/11
BBH
a) lot applicable
b) fot applicable
fllBBUl IiroillTIOl
a) 1 a>4 2* br after 2.78 19/119 It
200-al solatloa. Initial ••!««. 13. 5
a^/al at 0.1 hr
b) 2.5 and « he after 500-ig
•utalned-rclvaie project (5.5$
•I/kg). Initial Talae. 5 ig/il at
0.5 hr
Bealthf ao-rc-old Ml*.
DI04S; BB1SDUBBR BttBODS; UIOlTSl
BLOOD KISBtt ClMOtl CORPtllTIfS
BVtlDITIOIS
IBFEBBBCB
Roraie, B.D.
Boeeeeau, B.
Sied. s.
Brleo, B.
1980
N>
-------
B-Mtkyl
79-16-3
C3-87-I-O
H 73.1, m n c, m 206 c
fzssra
158«
OrU«
HIOSDII 100IB
nuniciL
8HBOD
oc
•ram
OF CUBS
100
um
lot gl»«»
•Ml
0.3 al/1
niiut IIPOIMTXOI
ian>l !•*•!•
•MSnBBin BRBODSl 01IM
unnici
B*rm«, j.i.
••ncy. I.I.
197*
-------
tcetnnlde. 2-(p-(2-kTdroxv-3-(lsopropTUnino|propoxy)pbenrl)- (8 CI]
5SII*.*"0*'"14*' *-C2-bydroxv-3-(p-Betkvletbyl)aalno)pronoxT|- (9
C14-H22-I2-03
Bl 266.3*, HI 1*6-1*8 C
CI)
TISSUE
1585
81004,
plan*
1586
Blood.
serna
1587
Orlii*
1588
Orlae
BXPOSTOB BOOT*
Injection
Xngestlon
Xngestlon
Injection
Xngestlon
Ingest Ion
IIHTTICIL
BBtBOD
BPLC
oc
BPLC
oc
•an BIB
OP CiSIS
irm •-
12
3*
12
3*
(1MB
a) 2.3-0.027 ng/nl
b) 0.239-0.053 ag/al
c) 0.162-0.165 ag/nl
d) 1.19-0.263 ag/al
a) lot given
b) lot given
a) 39.0-54.0 mg
b) 3.1-18.0 ag
e) 11.2-36.2 ig
d) 30.7-78.6 ag
•1 lot given
b) lot given
HBAI
a) lot applicable
b) 0.138 ug/al
O 0.282 ng/ll
d) 0.650 ag/nl
a) 0.5* » oc - 0.03
ag/il
b) 0.55 * or - 0.0*
ag/ml
a) «T ag
b) 12.7 ag
cl 2«.» ag
d) 51.9 ag
a) 258 » or - 13
•g/2» bt
b| 237 » oc - 1*
ag/2* be
uroiaiTioi
a) 0.2 aad 2* be after SO ag XT.
Eatliatad troa graph
b) 2.5 and 24 or after 25-ag. oral
c) 3.3 aad 2* br after SO-eg, oral
d) 3.3 aad 2* br after 100-ag, oral
lealtar aalea 21-28 jr of ag«,
before aad after dose.
fast*!
DINS; BLOOD PLtSBt; BIPZ1TBISI01;
•DOLTS; COaVIIITITI BTtLOITICIS;
OIIII
a) tteaolol » placebo
b) tteaolol » 50 ag/day
eblortballdone
DOM of 300 ag 2x/dar for 1 «k.
Patient* cltb ancoaplicated
kTperteaeloi.
Decreased beart rate and blood
(ceeaare. Snail decreases la plasna
realn aetliitf.
DIOOS; DIOO TRBIIPTl DIOO
IITBItCTIOl; BLOOD 381 OB; 01»Bi
IIPBITBISIOI; BLOOD NBSSOIBj IDOLTS;
COBP1I1TITB niLOtTIOfS; DXOUTXCS;
lltBBlHIOS
a) after 50 ag XT
b) Iftec 25 ag, oral
c) ICter SO ag, oral
d) after 100 ag, oral
*8-br emulative excretions.
•ealtbr nales 21-28 rr of age, fasted
before aad after dose.
DIOOSl BLOOD PLlSRIl RTPBITEBSIOIl
IDOLTS; COBfiltTXTB BTILU1TI«S;
OBXIB
a) Itenolol « placebo
bt tteaolol » 50 eg/day
eblortballdone
Cose of 300 ng 2x/day for 1 ek.
patients sltb ancoaplicated
brperteaston.
Decreased beart rat* and blood
pressere. Saall decreases ia plasaa
reala activity.
DIMS; 0100 tOBWll DI08
XRBIICTIOI; BLOOD SEtOfl) OlHI;
BTPntflSIOl; BLOOD P1ISS01I; IDOLTS;
COBIUMXTI ITkLOlTXOIS; DIVBMXESS
inniLkios
Bason, l.D.
liner, I.
Kocaak. G.
Cohen, I.
Bell, R.
1979
Teeev, i.H.
Leenen, F.B.B.
Geyskes, G.o.
Boer, P.
1979
Bason, l.D.
liner, I.
Kocaak. G.
Coben. X.
Bell, B.
1»79
Teeec, a.B.
Leenen, P.B.B
eeyskes, 8.0.
Boer. P.
1*79
-------
loataaid*. 2.2-dickloro-l-Cb«ta-hrdrojqr«lpk«- (hy4roKr««tkjl|-p-nitrophoaotkil)-, D-tkr«o-<-)-.
-------
tcatanlllda. 0'-hy4coiy- (8 a)
»cataald«, B-(«-hydcoiypbanjl)-
103-90-2
CB-B9-I-02
II 151.18, 9P 169-V0.5 C
CI)
TISSOB
1S90
Blood
1591
Blood.
plaau
1592
Blood,
•ana
BXMSDBB ROOTB
Ingaatlon
Ingaatlon
Ingaatloa
mimcil
tattoo
I0BBEB
or CISBS
1
..__
130
1
BUGS
58-18 ag/Bl
92-«0« ag/al
lot glvan
(IBXT
8EU
lot glvan
_
lot glfan
5.3 ig/dl
Ptai)
GtlEIlL IirOIBlTIOl
Banga of lavala fcoa adalaalca to 2C
kt latac.
S.S ye old tcaatad altk taplcln arary
«-B he foe 7 day*. 2 day* bafoca
adaluloa 300 ag aapicla aad 300 ag
aeataalaophaa van giran tltarnttaly
aiacy 2 kc. 300 ag doaa of
Jaat peloe to adalaaloai abdoaloal
pain and vo alt ing. it tdaiaalon:
eoaatoaa, gncaaponaifa to palatal
•tlaall, ttchypnalc »lth a*ldaac* of
•boek.
hy[*eaiioa*ilB. kypopcothcoahinaala,
alaratad alkalis* phoapnataaa,
aatabollc acldoala. Oclna «aa daap
ocanga-cad. Backad dlffiM, Boofocal
cacabcal dyafanctlog.
Divest Dioe THIBIPTI xotii cniotii:
BtOOD; C13I BXSTOBXBSl BBItTI
BII1IDS; BIOBOIOOIC MnrBSTHIOIS
langa of aaana, * be lafala la
ovacdoaa fletlaa. 60 cocalvad XT
cyataaalna, l-aatkloalaa, oc
c-panldllaalaa. tha caaalidae
cacalvad aappoctiia tkacapy only.
•atlaoUi idalttad to hoapltal la
Scotland foe paracattaol polaonlng.
Catlanta tcaatad »lth cyataaalaa
altbiB 10 he had fa>aat advataa
affacta.
Sarcca llvae daoaga, kapatic fallara.
oe tcata nnal fallae* la patlanta
gl««a aigpoctlva tkarapy oil}.
DBOOS; 0109 TBIUfTt BtOOD PUSIll
OIITBD KII8DOI; COIfUkTITS
BTUOkTXOBS
ratlait evealtad 5.4 g orac
afpcoxlaataly 12 he
saapla takan 1* he aftar laat doc*
3.S ye old Ctacaalan faaala, tcaatad
foe appac caaplcatocy lafaetloa.
Toaltlag, abdoilaal pala. bvadaeba,
obtaadad atata. oplatkotoalc
poatulng. Cactaln ayaptoaa dallac
to tbosa la Bar* ayndroaa
ratl«Bt lapcoTad bafoca dylag of
kapttlo and canal faille*.
lltac Baccoala, oallalac dagaaacatloa
aid aaccoaia IB kldaay, aid cacabcal
•da at.
DBDBS; D10S tUBkttl BLOOD SUOIj
CULDUli CtSI BXSnUUl (BUS
lEFElEICt
Bickaca, B.O.
lobacta, B.J.
1979
Pcucott, L.P.
Sitbacload, e.l.
Pack, J.
Saitb, I.J.
Peoodfoot, l.T.
19T6
-
fogaa. i.e.
Bc*ia*e, J-l.
1978
-
-------
intullito. ••-•Tta»y- |8 a)
ic*t»u«. B-(«-kyacoiypk«BTi)- (9 CD
109-90-2
CB-n-C-02
It 151.16. Bt 169-178.5 C
(conxmiD)
Txssn
1593
OclM
IS**
arlM
1595
Beta*
-
urosni ioni
XBgottioi
Isolation
in&RXCU
•moo
nc
OC/HS
i . ii
101 IBB,
OP CISBS
5
6
UBOB
7.7-32.0 Bg/2« he
lot gl»«n
nil
lot gltn
18.01
aiiiui xiraiBtnoi
l«nl« of •«t*bollto
3-MthrUUa-«-kracoiT«o«tuUUo
•«t«r 1100 «9 «c«t»Uo;k«a.
B»lt»r *oliBt*«ra lt-«« re old
OBoasi iiTiaounsi nin; n TITO
•ItUSXSt COBMIMXTB ntLBtnOISs
IBB JIISBTl BOMB CltOUII
6x100 19 tablet* ol pkcBuopiclOlM
hylrocklOElte. ( of
ClOCSj DIBS tBBUM J CBZLOBIII
•BTIBBl 10DLM) COBMItTXTI
IfUOHXOISi BBTUOLXSI; IRIBOUtIS:
zniBU
oninci
Ultek, 1.
tatli, 1.
Ckug, I.L.
fu*. P.
COIMT. »-«.
1971
JokBaoi. I.J.
Cktctcui, a.
1976
MtvraoA« 1.8.
lauck. B.I.
1978
-------
1C*tic acid. (o-(2,6-dlchloccanillno)phenrl|-, aonoeodin* salt (8 CI)
Benieaetcetlc acid. 2-((2,6-dlchlorophanyl)aaliio)-, aonoaodiua salt |9 CI)
15307-19-6
C1*-H11-C12-l-02.Ia
R1 282.6%. RP 213-285 C
TISSUE
1596
Bile
1597
OtlBO
1598
Orlne
EXFOSOtB tOOTE
Injection
Ingeitlon
Ingeetlon
tlaLlTXClL
RETROD
(adloaetry
Badloeetry
tadlOICtty
IDRBEl
OF CISSS
1
2
2
It KB
lot gl»«n
lot 'ipplicabl*
30.5-35.5 mq
lltl
5.3 eg
40 19
lot gl**n
6IIIIII IlrOSHtTIOl
Coll«ct«d dating 8 kc «tt«r 26.5-ig
doM. Only pact o( bil« collected,
tk«nfoc« appcoxluti *ala«.
76-fC-ald f«aal«
DIOBS: IITI-IIPLIHBITOBT I8EITS;
IIILOSSICSt OIXIE; BItBl 1IIUI
fOPOllTIOIS; COBPHITIfB BTIIQinOIS;
SIITSIIUID; nttBOLISRl IBtlBOUTBS
(ool«d 72-kc ocia«i. « Identified
•etabolltee accointed foe 701 of
eicceted 1«C. single 150-aj doee.
2 aale*. 51 aid 52 yr old.
otoas: iiTi-nruiHTOii AOBRS;
IIK.8ESICS; DRUB; illllL
SOPOIWIOIS; CORMUTZtB BTlWiWOIS:
SIITIBILIID: IBT160LISH: IRUOLinS
la aclne collected until eicratloD of
1IC tlctaally coeplete. 50- tg doee.
701 of 1«C accoanted for by 3
•etabollte*.
2 aalee, 78 and 72 kg.
noas; tin-xiruRUTOiT laiRS;
IlktOBSICS; 01IIB; Bill; 1IIUL
POfOLlTIOIS; COHPlllTin BfUDITIOIS;
SlIIIBILalD; IBTaBOLISH! IMIBOLITES
IBFBIEICE
Stleclla. H.
ralgle, J.I.
1979
Stleclin, H.
ralgle. J.I.
Sallaann, a.
lung, I.
•Icktec, ».J.
Kcleilez. B.-P.
tit. (.0.
•Inkier, T.
1979
Stlerlln. a.
Falgle, J.I.
1979
oo
-------
kcctlc «olfl, (2-hj4r«y«tho*j)-
13382-17-3
c«-n-o»
n 120
TX330B
1599
Ocin
-
BIPOSBU BOOM
Inhalation
IBUTOCU
BRBOD
tens
IOBBBB
or, CUBS
-
MBflB
512.525-760,955 «9/2« kr
IBIB
621.516 «g/2* kc
CBBBBll IBFOBBITIOB
BctnboUt* of 1.*-UouM Incing nnd
•tt«r 6-kc aipomr* to SO ppn.
Bnltky »!•• (Mnn «go •* ft, mn
••Igkt a* kg|.
Zj« itcitation Auing nponra.
DIOZtBBSt BIOOD PLUBtl OBIIIJ
BRUUItBS
BmnicB
loug. J.D.
Bnna. I. B.
tupr. L.I.
Cknnoratk. B.B.
BlM. O.B.
1977
-------
Icetlc acid, (2,a-dlckloropB«iOKT)-
C8-B6-C12-03
HI 221.0*, HP 138 C. B? 160 C at 0.« •• Bg
TISSDB
1600
Blood.
plain
1601
OrlBe
1602
Urine
1603
Brine
BIFOSOBB IOOTB
Insertion
Injection
Derail
iBgaatlOB
imrriciL
HBTIOD
GC
BadlOaetrT
GC
BOBBBB
or CISES
6
6
-
a) 2
b) 2
c) 2
6
BkBOB
5.6-3.3 D.B.
1976
(kanu, B.B.
(okll, J.D.
1975
-------
lotto «eU. (2.«.5-tcichlorophMoxr)-
93-76-S
C8-BS-C13-03
n 255. M. at 153 C (crr«ttl* Cccm b«M«M|
nun
ISO*
BlOOd.
nlMBl
1605
Orin
1606
Vein
Hfoam IOVTI
XagMtiO*
Ing* it ion
tuinicu
1BHOP
OC
oc
IOBBBB
or CUBS
»» «
b) i
d i
•1 6
b) 2
c) 2
6
lint
•1 S.O-O «g/tt.
b) 10.05-0 •«/•!
c) 1.8-1.65 «g/»l
A) 1.1-3.6 99*
b) 0.5-1.2 ft*
e\ lot *npUctbl«
•) lot 9l»«n
bl «ot gl»«n
c) lot 9i»«n
d) lot glt«n
Bill
•1 lot appllcibl*
b) lot •ppllctbl*
c) lot ippllcibl*
•1 lot Jinn
b) lot 9i«n
e| 0.05 pp«
•) 2T.* » or - 2.91
of dom
b) 50.2 » oc - 5.5*
of ton
e) 59.8 « oc - 7.6*
of torn
A) 63.3 * or - 8.6*
of AOM
eillUt IBT01UTXOI
•1 li«g* of *•»• 1-1*8 hr «ft«r 5
•gAl. fMk 22 «»/»! it 7 kt
b| 1-16B kc «ft«t 2 ig/kg. M*k IS
•g/il »t 7 fci
e) 1-168 kc «ft«t 3 »g/kg. M«k 17
•g/U «t 7 kc.
BcilthT ••!••
IIDUt PBSTICIDIS! BLOOD tU«l|
omit BRtaoLtTBS: nsncxoi
BISIDOB5
•1 Spnr opvntoM
b| SDCIT cr«« fomw
c) ilcecaft
-------
Moteaucetlc «cid, 3,«-aioy4ro*T- (9 CI)
102-32-*
ce-s8-o«
ai 168.15. Rt> 131-112 C
TISSUE
1*01
Ocl»
EXFOSOSE MOTE
InqastlOD
lIURICai.
RETROD
OC
1 OB BEE
or cists
«
MtSE
•1 «C5-S9S «9/2» hr
b) 116-500 19/2* kc
BBtl
t| S42 ig/2« ht
b) 290 if/2« hr
oiniti urotaiTioi
*) Standard Ss»g focnlttloD
t) Ml«r*4 •bwcptlon t«blat>
Bomf* 2.9-3.5 9/d«T I«»o4op«.
3 ••!• aad 2 f«»«l« pcrUncodu
p»U««t« «9«d 61-61 yc.
e
-------
lottlc acid.
(•-kr4lQXT-3-M<
: Bell, »-kT4co«
- (•
oxi-3-Mtkoxr- ft Ct|
joc-aa-1
C*-B10-0«
IB iBa
TISSOl
HOB
•clM
tiiosm BOMB
iBg*BtloB
IBUmCll
BBTBOB
OC
BBflBH
or CUBS
4
BIBB*
B| U5-TB5 B«/2* kc
b) 207-510 B9/2* kc
b) M2 B«/2« kc
""*"" *mmmam
•1 st«itet« «ng Coc.wUUfl.ft
t| paiajiij arr* tmif *^*r**fr>
Bong* 2.5-3.5 gy
-------
icetle •eta. trlchloro-
76-03-9
C2-B-C13-02
H 163.«0, RE 57-58 C. BP 196-191 c
TISSUE
1109
BlOOfl.
plassa
1610
Orlne
1611
22 ig/kg triclofoa
Bang* of a*aas, 1 aid 2* hr. Than
•hond coatlaaoaa lacr«a**. lo
41ff*r*ac*a b*t(**n drag* at any tla*
(l> O.OS) .
••altar »«l*a.
Ill pati*ntai *xc*aalT*
gaatcolataatloal gaa and flatai
daring chronic therapy .
siowivBst unoTics; OBOOs; DIDO
TBEB1PT; BBTIBOLI5B; BBTIBOLJTES;
HOOD Piisfli; contaiTifi BTU.OHIOIS
a) Roralag aaaplaa, expoied aorker*
b) afternooi aaaplaa, expoaed vorkers
cl Control*
Bipolar* le*el> of trlchlorotthrleiei
17C-*20 ag/Ca •
cnoixii oiauic conoams; mini
BntBOLITESi OCCOPHIOIU. BlUtDS:
OHO
•) SOO ag egal*alanta of chlcral
kjdrate, oral
b) SOO ag agalvaloata of chlcral
hydrate, rectal
c) SOO eg egni*alent> of chloral
retalae, oral
dl 500 ng egaliraleata of chloral
betalne, rectal
Talaaa are for trlchloroacetlc acid
excreted la 2* hr.
Bealthy, aalH, age* 23-29 71, fasted
before and after dose.
CBOBS: COWtUTItB ETtLOlTIOBS;
OIIBEJ IDOIH
BEFEBBICB
Sellers, E.B.
tang-Sellers, B.
Roch-lessr, J.
1978
tony, L.K.
Tander*ort, 1.
Polakoff, P.t.
197a
Slapsoa. 1.
rarrott, B.L.
1980
-------
IdclaBYclB (8 CXI
5.12-f«pktkBOU«dloB«, 10-((3-««Uo-2,3,6-tEU«o«y-»lpk«-l-ly*o-k«iopTtaBO»Tl>'>*T>-7.8.9.10-t»ti«kidro-
J32H-92-8
81 M3.58. B» 169-170.5 C
- (9
TISSUE
1612
BlOOd.
plaMa
BxtosoiB loan
iBJCCtlOB
IBUTTIC1L
BRIOD
BtLC
lOflBBI
or CUIBS
-.
5
UWB
•
3.91X1018-7) -
0.739X10 (8-7) BolM
BBH
_
lot applicable
SB nui xiroiHHioi
Bapatlc mou aitkcacycllBo. 2 aad
12 kr aftar t-kt If of »5 ig/ig m la
kapatle acton. 3.05110(8-7)8 at
0.2S kc {Initial *alM|. E«tlaat»d
(COB gcapk. Mta a*ailabl« tor otkac
dO«*B.
VattMtc with bc«a«t cawoc ef
adoaoeareiioM of bil« diet.
BcogrouiTo bopatie dl«*an, b«t BO
cacoloTaicilar di««a« oc BBBB!
dyitanctioB.
7-ao diaappaacaaeo of kapatie dUvtM
la 1 patioat. ractial mcpoora in 3
at U« otkoc « foe 1-« MBtki.
patloati. loakopaaia aid
tkcoibocTtopoaia, follond by ••pals
aad daatk IB oaa.
DIOOS! CRIHOTflllirt] IBOniSESi BIOOD
urnuici
eacaick. B.B.
1979
-------
lluliM. 3-(
-------
•lanlne. 3-(3,»-dlkydro*vpkenyl)-. L- (8 CI|
i-Tyroalne. 3-hydrozy- 19 CI)
59-92-7
C9-B11-B-0*
•« 197.19
TX530B
161 5
Blood,
plana
1616
Brine
ufosrai icon
injection
I age at Ion
Injnction
Infection
IBUniCaL
BBTBOD
BOBBBB
or CUBS
11
11
11MI
•) 0.89-0.015 ng/1
b) 0.035-0. 18 ng/1
cj 1.9-0.11 ng/1
d) 0.20-1.325 ng/l
a) lot given
b| lot given
c) lot given
d) lot given
•) lot given
f) lot given
g) lot given
h) lot given
MM
a) lot applicable
b) lot applicable
e| lot applicable
d) lot applicable
a| 2.5 % of dose
bl 11.2 of dose
c) 11.8 of doae
d) 29.6 of doae
a) 0.58 of doae
f) 13.5 of doae
g) 15.1 of doae
k) 18.2 of doae
OBIBUI iiroBBkizDi
a) levodopa 20 and 200 ain after
•tart of 50 eg IT over 20 ain.
Initial valae. 0.68 ag/1 at 10 aia (5
aabjecta)
b| Total dopanine 10 and «S ain after
•tart of SO ng IT levodopa ovac 20
Bin. 0.06 eg/1 at 200 nin, final
valne (5 albjecta)
c) levodopa 1 and 6 nr after 1000 ag.
oral, initial valoe, 0.825 ng/1 at
0.5 hr |6 aibjecta)
d| Total dopanine 0.5 and 2 nr after
1000 ng levodopn. oral. 0.«25 eg/1
at 6 hr, final valne (8 anbjecta)
•aage of neana. Bctinated fren
graph*.
farkinaonlnn patienta, ages 51-T* yr.
Oraga for dlnaae eitkdraan 3 days
before attdv.
DlOSSi IBOIC80SCOLU DISUSIS; BLOOD
•iisRi; 0003; ou»i amij
C08PMHITB BTllOlTIOISi kDOHS: 0108
TBEItVT
a} Total levodopa
b) Total dopaaiae
c) Total 3,a-dihrdcocrphearlacetie
acid
d) Total honovanilllc acid
a) Total levodopa
f) Total dopanine
g| Total 3,4-Uhydroxvphenrlacetic
acid
k) Total hoaovaailllc acid
•8-hr cnnalatlve eieretioaa after 50
ag IT (a-d), or 1000 eg, oral (e-kl.
tarklaaoninn patienta. agea :i-7*.
Draga for diaeaae •ithdravn 3 data
before atndy.
DIOOSj IBOICBB5COI.U DISI»S«S| BIOOD
H1SBM DOOS; OHM; JaPkll
COBPkBkTITB BTllOlTIOBSC kDOITSi 0100
1IBI1PT
UfBBBICB "~~
Suakara, K.
litanal, T.
Babara, T.
Borioka, T.
lakajina. B.
1980
Samkara. K.
litaaai, T.
Babara. T.
Borioka, T.
lakajlna. B.
1980
H
•vl
-------
II
9-90-5
»tl 26.9815*. BP 660 C. BP 2327 c, TP 1 •• Bg at 15*0 C
TISSOB
161T
Blood
1618
Blood,
Mrai
1619
Blood.
•ecui
1620
Hale
1621
(idmr
EIPOSOBB IOOTB
1IU.TTICH.
KBTBOD
ES
US
It
BS
IORBBB
OF C»SBS
1«
a
11
•1 132
b) 7*
O 86
BIBGB
lot glvaa
-
2.1-6.2 ug/1
21.6-38.2 ppi
a) lot gl»«n
b) lot gi»«n
c) lot glvaa
nti
12.5 • or - 1.0 ug/1
3.72 » or - 1.2 09/1
30.6 ft*
a) 8. »3 ppi
b) 10.1 ppi
c) 12.0 ppi
(IER PI6E)
CBItltL IITOBUTIOf
g««itkr «ibj«cti
ILOIIlOa; BSISOIBISIT BBTBODS;
TlllCIi BLOOD: OBIIB; BBT1L5
1»1«>
BITIBI; BETILSj ILOniOB; TIKE
ILIBIITS; OCCOPMIOBU BIXtBCSl
PCNUTIOB BIPOSOBfl BIOOD SHOB
Soiurr of iltolr 41ff«Ei>g
lltccttur* «•!•••.
lialtkr aJnltl.
ILOBIIOB; BBISOBBBBBT BBTHODS; BLOOD
EII3B1; B100B SEEDS; BILOIOB; BBTilS;
COBPIIITXVI ETIIOIIIOIS
Scalp kalr
OOBOCI fcoi 2 Tillages of falka
India u IB th« l»Tou« Tvccitorl**
Of T«B*»«ll.
Bill! TBIEIOBLl! BETUSt TI1CE
BIBBEBTS: 300IOBJ UOBIBOli SI1ICOI:
CBLOBtll: POTUSX1IBI SC11 010 1]
lltlBIOBt VII10IOI: C1BOBIOB; GOLD:
BtlQllSSS; IBOIj COBlLTl BICKBtj
COPPBB) SIBCi IBSBIICJ SBLEIIOH;
BIOBIBB; lotioioa; snoiTioa; sztfBi;
IITXMBTl IODXIB; CBS I OB) B1IIOB!
LlintlOB; CEIIOB: SIBMIOB: BBBCOBT
a) lo ranal dimaM
t) >cat« cmal failarai
e) cktoBle c«aal fall«r««
Dcr *t bail*.
mtop«l*< at ocu Boipltal.
TBICI ELEBEITS; BETtUl iOTOtSIBSj
CILIFOIItl; nOIEIS! LITEBi SPtEEI;
DISBISBS; ITPBBTBBSIOBl SODIOBl
COTISSIOHi CIICIOB: CBOSPBOB03I
M8IBSIOB: CIDHIOB; tllC; COFPBB;
1140! IBOI; BalQlBBSBl UORIIOB;
SILICOli TIT1IIOB; COeill; lICnLl
BOtlBDBIOHj TIB; CBEOBIOB; SnORIOl;
BIlIOBi LXTBIDB; SXtfBIl T1IIOIOR;
BOIOI
BBPBBSICS
•Halo, P.
Baua*. T.
1979
SotaMon. J.B.J.
Caapbcll, I.I.
Tapper. L.B.
Llagg, I.D.
I97a
fanicck. J.
coraalls, B.
19BO
PackoB>. l.K.
Talaidta, J.I.
Olraa*. B.
1977
ladrapcaalt, s.
llazaadat, B.T.
eoalck, B.C.
197*
00
-------
llaalaia
7*29-90-5
II
»tl 26.9815*. IP 660 C. I* 2327 C, It 1 •• If at 15*0 C
(COITIIDBD)
TISSBB
1622
LiTar
1623
Lang
162*
Lang
1625
1*11
IXFOSmf IOOTB
iiiinicii
BBTBOD
BS
BS
X-tay apactcoa
III
IOBBII
OF C1SBS
a) 78
b) ««
0 75
30
2
a) 50
b) SO
cl 3*
d) 23
IAMB
a) lot gl»an
b) lot gl»an
c) lot glTan
500.0-18570.0 ag/g dty «t
a) lot glfan
b) lot gl**B
a) lot gi»ea
b) lot glian
c) lot qiran
d) lot glvan
(•BIT
mi
a) 12.0 ppa
b) 12.5 ppa
cl 12.9 ppa
lot glwaa
a) 17 pattlclaa
b) 109 particlaa
a) 18.2 ag/g dty «t
b| 36.6 ag/g dty »t
cl 73.3 ag/g dty at
d) »9.8 ag/g dty «t
PISE)
eiiiiiL xnoBiiTioi
a| lo caaal disaaaa
b| Icata taaal fallataa
c) Caroalc carnal fallac*a. tala**
ata dty at bail*.
latopalaa at OCL1 Boapital.
titcB siBiinss onus torotsiisj
ciixpoini; nninsi LCTBB: SPLIBI;
CXSBISBSi BYPBBTBISXOBl SOOXOBl
ICTlSSXORi CtLCIOBt PBOSPBOIOS)
BIQIESIOB; CIDBIOI; XXBC; COIPBI;
HID; HOI: UieiltSE; 1108X108;
SIUCOl: TXTUTOBi COBUTt IKms
lOLTBDIIOli Tilt CBBOBIOB: SHORIOBl
BIIIOB; I. It BIOS ; SXLVBI; T1I1DXOI;
toioi
Sactloaa ot laaga ftoa aab^acta «ao
kad baaa bltaalBoa* coal alaata foe
23-50 yt.
aniLS; TUCB BUIBBTSi tLOBIIDBi
BIIIOB: BntUIOH BOBOII CIBOBXOBI
coppn: anatnoB; itoi: mti
I10I8SI08: BIIOIIBSB: IICIBL:
SILICOII SUfBBt Till TXTIBTOB)
flllDIVII LOIOSl C01LI OKTHC STITBS:
GOlBTIt IIIIBUS
a) CBB* 1,500 pattlclaa aaalytad
b| caaa 2,500 pattlclaa aaalptad
101 of pattlclaa la alt flltata rata
11.
2 valdata: 1 abo did alt-ate mldiag
la opaa apacaa, and oaa «ko did at*
valdlag la coaflaad apacaa.
caaa 1, aodatata aon-ap*clfic laag
dlaaaaa «ltk obattoctlr* and
caattlctlra coaponanta. Caaa 2,
aatata taattlctlva Ing dlaaaaa.
latatatltlal flbtoala aad dlap*n*d
aggt*gat*a of aactopbavaa contalalag,
datk btoaB aad black patticalataa.
BR1LS; ILORXIOBl OCCOKTXOIU.
III1IOS; RIlSOlBIBn BttHOOSj LOTOS
a) Pathata
b) Botha ra
cl Bala taaaagata
d) Paatla taaaagata
filaaa alao gl**a fot aadiaaa aad
gacaatclc aaana.
SO Balaaaaiaa faalllaa, a*aa ag* of
fatkata, *6 yt. aothata, «1 yt. «3
aala cblldcaa, 12-2* yt aad 36 faaala
cbildtao, 12-2* yt.
CltCIOB; SOOX08I BIQIESIOB: ILOBIIOB;
SOLfOI] CI10IXII) TM19IOI;
BlIOllBSBi COPPBIl TI1CB BLEIBITS;
HOOD PIBSSOII; IBI OOIIBli BBTtLSl
IIILS
ladtaptaalt, s.
llaxaadat. O.T.
ooalck, B.C.
Ctabl*. J.f.
Kaanaa, B.B.
lOlOllCB. P.I.
iBOtt. B.J.
Bolts, J.I.
Ootakl. C.B.
1967
Stattlat, L.I.
Ototk. O.I.
Backay, 0.1.
1977
Baaltoal, I.
Kolttyokaaa, S.B.
Plate*. J.O.
Sckaaackala, B.S.
1976
-------
7*29-90-5
tl
Itl 26.4815*. IP C60 C. BP 2227 c. It 1 •• 89 at 15*0 C
(COITIIUBO)
TISSOB
1626
Splwn
1627
Ocia*
BIPOSHBB RODTf
aBaLTTXCtL
RBTROD
BS
ES
BOBBSB
OF CiSES
a| 92
b) 39
c) 76
1«
BllQB
a) lot gl*«n
b| Bot 9l»«o
c) Bot gif«n
Bat given
BIH
a) 10.7 ppa
b) 10.2 ppi
e) 16.1 ppi
a.7 » or - 2.5 og/1
CElmi. IBFOBR1TIOB
•) to r«oal di«*a««
b) icat* renal failures
c) Chronic renal failerea
b| tat c) different, K0.01
Tila«« ac« ACT >t bail*.
autop>l*a at OCL1 IKwpltal.
TI1CZ BLBIBIIS; BBTklS; aOTOPSIBSl
CILITOIlIt; KDIBTS; LtVBI; SPtBIl;
DISBISBS; BIPnTMSIOl] SODIOR;
tOIlSSIOSi CIICX01; fBOSPBOBOS;
IIGBBSXOBi ClORIDIl «IC; COIPBB:
tltfl! noli BtBOalBSB; UOIIBOB)
SILXCOBl TIIHIOBl COBtLT; BXCKBL)
BOLTBDBBOB; TIB; CBBOHIOHj SHOBTIOB;
BIIIOR; lltBIDB) SILTEI; TIBIDIOBj
BCBOB
Btaltkr «Bbj«ct«
ItOBXBOB; BBaSdBBBBBT BBTBOD3;
FBUCBi BLOOD; OBtBBl OtaLS
SBFBBEBCB
Xnicapcaait, S.
il«xand«c, O.T.
Oonlck, B.C.
19T«
lllain, p.
Bauru. T.
1979
to
O
-------
Inonl*
•3-1
-
H 17.03, •* -77.T C, tt -33.35 C. TV 10 at! at 25.7 C
tXSSOB
1628
Blood.
plaa-M
mosoiB loan
.
tBURICkL
nnoo
coiociMtry
_
IVIBBI
OF C1SBS
a) 20
b) 10
o) 5
d) 10
UNB
a) lot glvaa
b) lot gl*«n
e) lot glrm
d) lot glvm
Bill
al M.9 » OE - *.5
b) 70.7 » or -18.6
og/dl
C) 76.8 » or - 20.8
«g/dl
dl 82.6 » DC - 16.7
99/41
_. .
sunn. IIFM UTIOI
a) Contcola. ag«« 28-60 jt
b) Rcaodtalrnd pttimta. aga* 38-6«
c) Potltokoal dlalrxad patlmt*. tg«
««-CS Jt
d) loBdUlynd pati«Bt« diff«r«d fro*
coattol*. r<0.001.
Patioata «ltk ckcoate xwial failar*.
HICj RBTatSl HI II 111 8BC4M1ISR:
BIOOO rtasiii MTTMocmsj
1IOKOCITBSI Mill DISI1SIS! 1901*5;
CCmUTXVI ITiMlHOISj 1HIOII1
BimBICB
BakaJaB. 3.B.
Icuad, i.s.
Babbul. p.
Brigga. I.t.
IcOoaald. r.D.
1979
-------
D- 0 en
(* ca
•11. *.c
JMHCB;
K>
-------
M
<* r»«
* 31
•I W. 3
*| tv, «
e»
ut» mtttf «.» •«
•.zs ••
«.» ••
f* ntfk «* O
B.S.
•. •-•.
-------
IniUn* (8 CI)
B«nt«n»«ln« (9 CI)
42-53-3
C6-H7-B
B« 93.12. BP 18«-1B6 C
TIS5UB
1638
Or In*
BIPOSDBB IOOTB
Tng**tion
IliLTTICIl
RBTBOD
HOHBIB
or CUBS
6
B1ISE
fot gi*«n
6.9*
GBIIRtL IIKBIITXO*
6 i 100 19 tiblvti ot ph*oaxopirldl>*
hTdrochlocia« \ ot 40M in 2«-kt
acini.
6 kMlthT •«!•«, «9«d 25-40 yc>.
DIOGS) IBTIBOUTBS; OIHB; CIltDt
nrmtct
Johncon, >.J.
Ckwtrind, t.
-
to
-------
•BtkCBBlUc «ci4. l-(«-(trl«taoroB«tByl|-»-*«l.BOlTl)-. 2.3-4ihydco«jpropjl ut«rJJ d|
••Btolc BC14. 2-«B-CtElflBoroB«tBn)-»-fl«iBOliByl)BBlBO)-, 2,3-alkracoxTBnm ««t«c (4 CX|
23779-99-9
C20-B17-r3-l2-0* '
•I »OS.37. IP 17»-180 C
TISSOB
1637
inosvu toon
IIU.TTIC1L
BKIOD
ColoclMtry
nc
-
•OBBBB
«« CUB
7
-
urn
lot gl»«B
•It!
6BIIUL XlfOlUTXOI
D«t«ct*A OBIf *• ••tabollta,
ClOBtBfCBlC BCld
Italtky BBl«>. BOII 21-2S yr.
OlOOSj DIDS TnitPIi BlOOOl UOUSl
OIBOOI; IRMOlIRSl II TniO
I1UTSIS
-
tBninci
lynB, •.(.
Boll. 1.
SIBBOOB. B.I.
SBlth. B.
Mcbar, 1.
1979
NJ
-------
Inthranllic acit, »-chloro-li-furfiiryl-5-SBlfasoyl- (° CI)
Benxolc ncid, 5-(aalnosulfon)l)-«-ehloro-2-((2-furanrln«thyl)aninol- (9 CI)
C12-H11-C1-I2-O5-S
IB 330.77, BF 206 C
TISSUE
163*
Blood.
serin
1639
Blood,
seran
16(0
Urine
16*1
Orine
IIFOSOIE BOOTB
Injection
Injection
Injection
Injection
UalTTICaL
RETROD
Flaorosetry
rlaorosetry
,
TtC
Flaorosetry
rlaoronetry
IOHBBB
or Casts
5
a) 6
b) 6
a
BlIGB
6.3-1*. 6 ug/nl
•) 2.6-6.5 ag/nl
b) 6.3-8.9 ag/nl
c) 7. 5-2 S. 6 ag/nl
n) 128-0.3 ag/nln
b) 2*5-0.6 ag/sln
n) 18.4-39.6 ng
b) 36.4-69.6 ag
c) 55.8-116.8 ig
RBal
11.0 ag/il
a) ».73 ag/nl
b) 9. 1 ag/nl
c| IS. 3 ag/sl
a) lot applicable
b) lot applicable
a) 27.1 ng
b) 50.3 ig
c) 87.6 ng
CEIEIIL IITOIRlTIOl
l(t«c »i09l« OOM, 120 »g. It
Malta. 62.0-75.• kg.
functionally ancphric patient* bad
kl9h*c listEibition ?ola««, longer
plan* kaie-ll(«, lesser clearance,
and note rapid non-renal eliilnation
of drng tban nornaln.
HOOD PLISBI: BtOOD SSBOR; OfOO
TBBSIPI! 01IIB
a) tfter «0-ng dose IT
b| Tine lero folloclna 80-19 doee
c) Tine xero (ollonlng 120-ng dae«
Bealthr ial««, 1S-«* yr old, as.5-72
kg-
Fanctloaally aaepkrlc patients had
higher distribution rolaie, longer
plesna half-life, lesser clearance,
and nore rapid oon-renal elimination
of dreg than nornals.
B100D ttlSlll B1OOD SEIOB; 0(00
TBBBIPTl ffllll
al RypertenslTe patient*
b) controls
lange of nean rites of clearance 0-1
hr nnd 12-2* hr after to 19.
Patients ulth serere hypertension <6
so, nit* vascalar conplicatloas, ages
•2-63 yr, nornal controls, til
fasted.
DIOSS; DIOG tRItPT; BIPBITBI3IOI;
oiiHiK; norms; BIOIBTICSJ OIIIB;
IDOLTS: COIPtBaTZTE BfUDlTIOIS;
SODIDB
a) lenal excretion folloiing dose of
•0 19, resainder nonrenal
B) lensl eicretlon folloving dose of
80 eg, reminder ncarenal
c| lenal excretion folloning dose of
120 19, resiinder noareaal
Baalthy nalea, 15-aa yr old, a5.S-7J
kg veigkt.
rinctlonally uephric patients had
higher distribution TO lane, longer
plaaia half-life, lesser clearance,
and sore rnpld ion-renal e 11 ai nation
of drag than norsals.
E100D rliSII; BLOOD SB MB; DtD«
TBBiirr: OBIII
Cutler, I.E.
rorrey, t.l.
Christopher. T.G.
Klnpel. B.H.
1971
Caller, I.E.
rorrey, l.f.
Christopher, T.G.
Klnpel. B.R.
197«
NJ
Indreasen, r.
Fedecsen, O.L.
Rikkelsen. E.
197B
Catler, I.I.
rorrey, a.I.
Christopher, T.G.
Ilipel, B.fl.
197»
-------
Intlaonr
7MO-36-0
Sb
Sb
It! 121.75. IF 630 C. B? 163S C, TV 1 aa Bg «t 886 C. 10 •• Bg »t 960 C
TISSUE
1612
Bloo4
16*3
Bale
16««
Orl«*
IIPOSDtl BOOTB
Inhalation
Inhalation
IIILTTICII.
BBTBOD
It
lOBBii
or ctsis
-
•t
bl
c|
d|
•1
11
•1
W
c)
«l
•I
UNI
•1 lot applicable
b) lot applicable
c) lot applicable
4) lot applicable
o) lot applicable
lot tet*etabl*-3.10 ppa
-
•I lot applicable
b) lot applicable
c) lot applicable
4) lot applicable
o) lot applicable
Uil
•)
-------
iDtipvrlne (9 CI)
3B-Pyca»ol-3-one, 1,2-dlbvdro-1.S-dlnethTl-2-phenyl- (° CI)
60-80-0
CM-B 12-12-0
Bl 188.22, BP 111-113 c
TISSDB
16*5
Blood.
plant
16*6
Saliva
16«T
aria*
BIPOSOBg ROOT!
Ingest ion
Inge at Ion
tngestion
illLTTIClL
RETROD
Coloriietrv
Colorinetry
HPLC
IORBSE
OF CISIS
28-8.53 ag/sl
29.0T-B.63 ug/sl
68.n-78.01
lot applicable
lot applicable
73. -i
OtllltL IIFOIUTIOI
2 and 2a hi «ft«r 18 BfAf. Taloca
in saliva and pla«M siiilac about i
ac aftcc oral do««.
»ol«Bt««r» OB no otkac
>2 «k and «ltn coffM and alcohol
litak* aod*lt to oil. Af** 23-60 re.
Fa«t*d O
DI06S; UaiatSICS; alTIPTHTICS:
BtlSOIiailT IRRODSi SUIT1; BLOOD
tUSRa: CORPIUTXTE BT1L01TICIS;
MFOllTIOIS
2 and 2« he aft«r 18 aqAg. TalM*
in saliva aad plaiaa (liilac aboat 1
be after ocal do**.
Btalthv *ol«nt*en oa BO other drag*
>2 «k aid «ith coftee and alcohol
intake aodeet to nil. tgee 23-60 Jr.
Fasted overnight.
D100S; 4IILGSSICS; iRIPTIBTICS;
BIlSDIEIBIT REtRODS; SILITt; BLOOD
FlISRl; COHMEITIVE BTalDATIOtSi
IIIR1L FOPOHTIOIS
I ct dose in 48-hr urine. Flaena
halt-life and clearance highly
correlated eith that of antinrrlae.
Student nog-inokeci. agee 21-33.
OIUEPkRS; HUaESICS; VZSCOESII;
REtaBOLISI
IEFEEMCE
Welch, B.B.
OelBoella, I.L.
ling field, R.
Patter, T.I.
1975
Belch, E.R.
Doangeli*, I.L.
llngfield, R.
Famer, T.I.
1975
KelleceaBn, c. H.
Levtea-lCellecnann, B.
1979
00
-------
imxlc
74*0-38-2
as
ktl 74.9216. IP 817 C at 28 ate. n 613 C (snbllses), TP 1 •• 89 «t 380 C, 10 aa Bg at MO
TISSUE
16*8
Blood
16*9
Blood
1650
Blood.
sernn
1651
Blood,
whole
IXPOSOII tOOTB
Xnkslstioo
Dereal
klkLRXCkl
BBTBOD
_-
US
BOBBBB
OF CUBS
•) 1
b) 1
C| 1
d) 1
•I 1
a
1
a) 69
b) 35
11IOB
a) lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
•) lot applicable
a) lot detectable
b) 0.02-0.08 ppn
lot applicable
a) lot given
b) lot given
(1BIT
RBkl
a) 0.18 egAg
b) 0.20 xg/kg
o) 0.082 sg/kg
d) <0.096 sg/kg
•) <0.0*« sg/kg
a) lot applicable
b| lot given
2500 ppn
a) 0.32 og/100 nl
b) 0.20 ug/100 nl
PICE)
eiiiuL xiroBBaTxoi
*| fockec «ao cleaned drain
b) locket wao cleaned dcain
c) other norkec nearby
d) other •ockec nearby
e) snpecTiior
Ia»te kerblcldee ga*e rise to araine.
BeiolTtle nnenia, renal fallcre.
voiltlag. renal inpaireent
1RI80IT) MSBIICi kISBlIC OH1IIC
coarooiDs; unia: BMOD; RBTILS;
IBSflCZDHl IIOOSTIIU BBDIC»B|
iniBTSt oun
a) 6 of 8 cues
b) 2 of 8 caeea
Chlneee-hecb-indKed t< polscaing*.
lol*oil>g cue* iron Singapore
general Roepital.
syiptow inclade hjperpignenutlon.
hrperkeratonin of (all* «»d nolu.
depignentatlou, palnar and (lantar
hiperkidroeli, nnltlple areenlcal
keratoeee on trnnk and llnbn, skin
cancere on liebe and truk, fca*al
cell carclnona, Boven'* dleease.
toiic (ennarlnotor polynearotatkr.
Cine finger trenorn, chronic
headache, lethargy, «eakneu.
laionnla, neat* or inbacote gaetrltls
oc gaetroenteritie, acate toxic
hepatitis. Fe deficiency •••tin.
•qianoan-cell carclnona.
tisEiic; Bin; Bins: ram; BLOOD:
szioiioiB: IBTU POisoiiiG: anus
(ellOBlig fatality
iisticiDist usiiic: kLuioics:
CMBOB XBOiaknc COBPOOIDSI nooot
LIIBS] KIDIITS: Bllll OBXIB: IDI8S!
KkBT; SPlltl: BBkXBl BMOD SB10B|
1IBIBSSBB: CkSB HISTOBISS
.
n) Sxposed notkers
b) controls
Icrkers enployed at least 1 yc at
secoxdacy Pb seeltec nnd controls
(ton nearby 11 processing plnnt in
California.
amis: kisBixc: IUDI BLOOD; BLOOD
tllSBt; RIXBl COBPkBkTITB
(fkLOMIOIS: BBkBIM: IEDBOLOGIC
BIIXPBSTkTIOISl OCCOflTIOIkl BklklDSj
XIOOStBTISl SBBLIBIS; CkLXTOBIXk
Bmum
Paclsk, a. a.
eixss, i.
Unbrongk, B.
1979
Iny, C.-B.
Seah, c.-S.
1975
Bayes. f.J. , Jr.
Tanghn, w.l.
Bnlok. I.I.
Spiny, O.H.
Brown, C. P.
Borgan, D.
Canpion, D.S.
Broildy, B.L.
Taleatlne, J.L.
Coniek, B.C.
Hassey, P.J.
cnlvec, B.D.
1979
NJ
\O
-------
7MO-34-2
II
itl 7«.9216. BP 817 c at 28 at*. B? «13 C (aobllaaBl. »p 1 aa Bg at 360 C. 10 aa Hg at ««0 c
(COBTIBOBD)
TISSUE
1652
Blood.
attola
1653
Blood.
•kola
165«
Rale
1655
Bale
SIPOSOBE BOOTS
Decani
Inhalation
Ingaatlon
Ingaation
Daraal
1BU.TTIC1L
BETBOD
MS
MS
MS
MS
BOBBfB
OF CiSBS
al 69
b| 35
al 33
bl 21
e) 38
d) 28
a) 21
a| 36
b| 29
e| 97
d| 67
•1 30
f| »9
al 69
b| 35
BlIGE
al Bot givan
bl Bot g Ivan
-
a| 0.18-5.5 ag/100 Bl
ta| 0.08-0.73 ag/100 al
c| 0.03-0.85 ag/100 al
d) 0.01-3.50 ag/100 al
a) 0.25-0.7* ag/100 al
a) Bot given
bl Bot given
cl Bot givan
d| Bot 9l»«n
a) Bot givan
f) Bot given
a) Bot givan
bl lot givan
(BEIT
REiB
a) 0.32 ag/dl
b) 0.20 ag/dl
a) 1.33 » or - 1.18
ag/100 al
bl 0.«2 » or - 0.17
ag/100 al
c) 0.29 • or - 0.18
ag/100 Bl
d| 0.51 • or - 0.65
ag/100 al
•I 0.«9 » or - 0.12
ag/100 al
Baaa » or - SD
a| 5.7« ag/g
b) 2.29 ag/g
c) 0.»6 ag/g
d) 0.»3 ag/g
a| 0.51 ag/g
f) 3.29 ag/g
a) 7. « ag/g
bl 1.2 ag/g
PICE)
GEBEBiL IIFOBilTIOI
a) saaltar vcrkara
b| coatrola
tic lavala for Pb, Cd. and ic also
givan.
Laad aaaltar cockers, aaan aqa »2.5
jr, aaan aaployaant 11.3 yr.
Coatrola, aaan ago *9.7 ye, aaan
aaployaant 8,» yr. ill feoa
California.
BtTILS; LEiD; 1BSEBXC; C1DBIOB;
ElOOD; ADULTS; OCCOP1TIOB1L UXUDS;
COBF111TXVB ET1L01TIOBS; ClLXPOIBIl
at 393 ag/1 la drinking vatar
b| 123 ag/1 IB dcinking «atar
c) 98 ag/1 ia drinking vatar
dj 51 ag/1 IB drinking vatar
at <6 ag/1 la drinking vatar
laic aad ariaa lavala reflected
latak*. blood lavala did sot.
Baaldaata, foe not <1 fc (avaraga
caaidanca: ».3 » oc - 2.8 to 9.6 »
ec - 8 ye), of 2 Ci aad 3 If
coaaaaltiaa. Ivaciga ages 26 » or -
1! to •» • or - ia yr, 23-»3»
aaokaca.
art its; lasEBtc; BITEI POLLOTIOB;
DimiBS BITES; BLOOD; Oil BE: BUB;
coBMBiTifE mioinoBs;
BIOiCCHKOUTIOB; CILirOBBIl; IBTID1
at Bottled delating vatat
bl salt eked fcoa »all aatac to
bottled aatec ia proceeding 3 ao
cl Ball vatar. > 100 ag/1
d| Boll aatec, > oc » SO ag/1
a| Ball aatar, 50-99 ag/1
(I Boll vatar, < or • 100 ag/1.
Oroap ft aigniflcaatly dlffennt fcoa
groapa el . d) aad al .
Baaldaata of Eatar Doee. llaaka
UlSCll IBSIBIC; DBIBTIBO BITEB;
OBIBE; BtllSl BilBj TB1CE BLHIIT3;
BIILIB BlIlBOS
al Ixpoeed aockara
bl coatrola
Icrkara aaployad at least 1 ft at
aacoadacy Pfc saaltar aad coatcols
Ccoa aaacby 11 pcooaaaing plant ia
CalifanU.
IRlLSi 1BSBBIC] HID; BLOOD; BLOOD
PtiSBl; BlIBl COBPaUTIVE
EfaLOlTIOBSt BEIBIBCi BEOBOLOCIC
BIBITBST1TIOBS; OCCOMTIOI1L BU1BDS;
iBDosniis; sinnist ciLiromi
BIFEUBCE
spivay. O.B.
Brova/C.P."
Baloh, B.B.
Caapion, D.S.
•alentlaa, J.L.
Baaaay, f.J.
Brovdy, B.L.
Calvar, B.D.
1971
Valaatiao. J.L.
lang, B.It.
Spivay, 6.B.
1979
Barciagtoa, J.a.
Blddaagh, J.P.
Borsa, D.L.
Booaaoctk, J.
1978
Balok, B.B.
Spivay, O.B.
Bcoaa. C.P.
Borgan, D.
Caapioa, D.S.
Bro«dy, B.L.
Talent ina, J.L.
Goalck, I.e.
Bassay, F.J.
Calvar, B.D.
1979
CO
O
-------
ICMDlC
7MO-3B-2
la
It! 74.9216, St 817 C at 28 ata, B? 613 C (aabliaw), tP 1 aa Bj at 380 C. 10 aa Bg «t MO C
(CORIIOED)
TISSOB
1656
Bair
1657
Balr
1658
Balr
1659
Bair
________
EIPOSOIE BOOM
lageatioa
Ingeation
iniRicu
BBTBOD
Bl
Chen
US
IOBBBI
or CISBS
11
a| 20«
b) 27*
1
a) 35
b| 21
c) *5
d) 25
a) 10
11MB
lot detectable- 1.15 ppa
- -
a) lot given
b) 0-1. BO ng-S
-
lot applicable
al 0.36-1. 31 ag/g
b) 0.01-1.39 ag/g
c) O.OB-2.«2 ag/g
d) 0.07-0. a* ag/g
e| 0.0*-0.39 ag/g
(IBXT
mi
0.50 ppa
al 0.92 ag-X
b) 0.27 eg-(
For aaaplaa over 0.10
ng-*
12 ppa
») 1.16 » or - O.BO
ag/g
b) 0.50 » it - 0.37
ag/g
e) 0.57 » or - 0.«5
ag/g
d| 0.«8 » or - O.M
ag/g
e| 0.15 » or - 0.11
ag/g
leao • or - S. D.
PIOS)
QBIEUL iiroiunoi
-
Scalp knlr
Donors fron 2 village* of lalka
Indian* in the laaioaaa Territories
of Tenesaela.
BIIB; VBIESOEU: BItU.3; TI1CB
EIEBIRS; SOOIOB! 1-DBIBVBl QLICOIi
CBLOBIIB; rOMSSIDBl SCIBDIOI;
1IT1IIOB; TllaDIOBl CBBOBIOB; COLD!
BIB81IBSI; IBOI; COUIT: IICBBI;
COPPEI; tIBCl USE IIC; SBLBIIOBi
BtOIIIB; BOBIDIVIi STIORIOB; SHTBB;
IRIBOIT; XOOIIBt CBSrOB; B1UOB:
uiTiiioB; CBBIOB: SIBMIOB; BEICOBT
a) 1968-1970
b) 1976
children and adnlta born and living
in intofagaata. Chile.
larnnad*. syndrone, lachenla,
nyocardlal infarction, aeaanteric
throaboaia, bronckleetael*
tlSBBIC; Bill! Mils; OBIinN I1TII:
COBMBHIVI miOlHOIS; BBltTB
BlIllDSi 1DOITS; CBItOIBI; CEILS
__
tolaoniag fatality
PESTICIDES; USBBIC; 11ULOIDS;
C1BBOI IlOtOinC COBPOOIDS; ELOOO:
tITEt; IIDIBTS; Bill; OKIE; tOIOS;
BIUT; SPLIEI; BI1II; BIOOD SEBOB;
(IBIBSSBIi CISE BI-tOBIlS
a) 193 ag/1 in drinking ratec
b| 123 ag/1 in drinking later
c| 98 ag/1 in drinking utter
4) 51 ag/1 la drinking vater
e) <6 ag/1 In drinking rater
Balr and arlae level* reflected
Intake, blood level* did not.
lealdeote, (or not <1 yr (avaraoe
realdaacei ».3 » or - 2.8 tc 9.6 »
er - 8 yr|, of 2 C» and 3 IV
connanitle*. tverage agei 26 » or -
If to »« » ot - 1* yr. 23-*3I
aaoker*.
8RU.S; IBSEIICi IITBB POUOTIOI;
CIIIKIIO BHIlt B.OOD; Olllli Bill;
CCBPaBkTIfl BniOllIOIS;
tlOlCCOBOHTIOl; CUIPOIIIl; IBTtDl
uraiEici
Perkoa*, I.E.
Telaadla, J.I.
Dieaaa, B.
1977
-
Borgoao. J.B.
Ticaat. p.
Ventnrlao, B.
Infante, I.
1977
Baye*. i.J.. Jr.
Vaagkn, l.K.
1977
Valentin*, J.L.
Rang. B.I.
spivey. e.B.
1979
-------
1 runic
1MO-3'-2
II
ktl ''•.'Jit. *t »\"> C >t 2S ««, It SI] C (a*fclUa*|. TT 1 •• 19 tt J»0 C, 10 •• 19 It MO C
(comiuioi
TtSSII
1«tO
••It
1*61
U«2
1««3
tiMsni IOOTI
I*9*«tlO>
1*90 *tlo.
UlimCkl
SIT*OD
.
.
US
101 Ml
OP CkSB
71
1
5
ft) 3«
b) 29
C| 97
41 «7
a) 30
Q »»
MM*
*> lot 4ataetula
b) 1.0-S.O pp.
c) S. 1-10.0 pp.
4) 10.1-20.0 pp>
a) >20. 1 pp.
lot tppllc.bU
1.2-73 ppa
•) lot 9l*OB
b) lot 9l>«
c) lot 9l*a*
4) lot «l*a*
a| lot alt**
f) lot 9l»%»
Mil
ft) lot .ppltc.bl*
bl lot 9l*a*
c) lot git*.
4) lot 9l*a«
•) lot 9lm
>S pp.
31.5 pp.
«| 5.0 «9/9
4) $!ot •(/•
«) 2.6* »9/>9
O ">. Si .9/9
CIIIIU. IIPOIItTIOl
.) •! of 7* cua*
M f Of 7« CMOS
cl * at 7« cua*
d) 1 of f* ccaaii
a) 1 of 7* cua*
39 Mia*. 35 foMla*. T0 cklMM. 1
Iftl.T. 3 I*41». S2 k44 cktcaic
(Olaokl.9, 22 k«4 «c«ta pol*c*l*9.
Ill ••!• |»tlut« at Sl>9*poca
Caaattl lo*plt*l.
]|*»to>* l.cl.4« kypataltaaatatlo*.
kyparkar.ta*!. of p«l** «*4 *olw.
4*plf*«itatloi«> Mlaat «>4 (lut«c
kfpatkl4teala, ••Itipla .raatlcal
ktr.toaa* a* tc**k «*4 llito, ikl*
CMcati 01 ll*b* »4 trvftk, btul
call c.rcltoat, bo«a>'* tlMaia,
totlc •okaotlaotoc polnaatopatky.
fi*a flk^at tc*«or*, ebtoklc
licaail*. teat* or aabte«t« a«*trlti*
at 9««tcoa*tacltl*. ac«ta tadc
kap*tltl*. fa 4attda*cT ••ail*.
*«uiou-call cctclaou.
ItSniCt IHl; IkXUl mil; IWOI;
siiBiroiii inki rotsoim; rrnis
(tsticiiiSi usnici tiKiioio:
CIIIQI noiaanc COIMMTIDSI DUMB)
HIM: iiBfin: um rant: IMBS;
HUT: siutii mil: UOOB am:
iimssiii cast njtoirts
riSTICIBIS: MSBIIC; kLKllOICS]
cinoi tioiuitc coirooiBSt ooo»i
itflll (IBlini nil; mil: tlMS)
HUT: sruii: iikii; nooi moii
IIIIIS3II; CkSI KSTOIIIS
•1 tottla4 4ti«U>9 mtot
b| ]«ltck«4 tra «oU »»tar to
kottla4 Mtac la »taoa«4i«9 } *o
c) i«U ••tat. > 100 aa/1
4| lall ••%•!, > at • SO •a/1
•1 loll Mtac. 50- •» «9/l
t| lall ••tat. < at - 100 «9/l
«co»p () •IfUtletiUr «lttara*t (to*
el , 4) . ••« a) .
ta«14a*t* at tator Boaa. kl««k>
iikiiki kuiiici BuntN ftnit
mui nils; imi TIKI unimi
IlkUl UUIM
iimtici
Tay. c.-l.
Soak. C.-5.
1975
l.r**>*<-J-. Jt.
?.*9k*. I.I.
•ara>. *-•>.. Jr.
VftMk*. «.».
IU4»ok. i.t~.
•oraa. B.I.
•aawertb. J.
1*fO
U)
S3
(HIT P»S«I
-------
nssvt
1U*
IMS
Drill*
VrUo
•
traosiu IO»TI
Xoooatloi
klUIRCU
C»00
115
IS
~~
IMOM
OF CUB
»l M
kl J73
-_
a) 3C
b| 2»
cl 97
111 67
•1 30
f) •»
1
•HOI
•1 lot «l»oi
b| 0-7. SO i9-«
»l lot lotoctoblo
bl 1.0-S.O ppo
•) lot 91*00.
b) lot 91*01
cl lot 9lT*l
4i lot 9iT«
• 1 lot 91*0*
f) lot 9l»oi
tot applicable
(HIT
mi
•1 2.0* 09-*
bl 1.«1 09-1
•I lot applicable
bl lot 91*01
a| *.31 19/100 il
b| 3.92 19/100 il
c) a.05 «9/100 il
a) 3. S3 19/100 il
o) 1.S2 19/100 il
(1 17.03 t«/100 il
SO.* 19
us EI
eiiiui ivoiurxoi
I) WO
k| 1»7«
filooo for auploa o*or 0.10 Bf-S
CklUroi ii« i«ilti boa u4 11*U«
ii ko.tofi.9Ut*. Cklle.
••r*ii4'« arairoMt Iccaoili.
•T0oar41al Ictirctloa, waoAMrle
iisnici uni iiiu> tinitn HTU;
COIMUTITI mioiTmsi nitti
iiuim mini cnuini cun
-
a) 2 of • ciio*
b| 2 of * CMM
Ckilia«-bocb-li4*eo4 l« polacolkgs.
•ol*oili9 CIMO fcoi Sligapon
COToril loaalt*!.
SfiptoBi iicloio kyioCBlfBoitatioi.
k*porkor*toal« of (•!•• 1*4 loloB.
ii»l9Mititiou. pilMr ail (lutar
ifpirkUroali, ulUplo arooiioil
kicitoMi 01 triik 1*4 lliba. «Ui
OMOOT* 01 Ucka *»4 trvik. baoal
coll carcliOM. 5o**i*i 41«oMO.
toilc •oioocliotor •elTMiro|*tkf.
tin (U9or troiori. ekcoilc
kuticko. I«tkar97, 100 19/1
4) toll utor. > or - SO 19/1
•) loll iitit. SO-t* 19/1
t| loll utot < or • 100 M/l
•roip 0 il9iiflc*itlt 4ifton»t tcoo
9ro«p« el , 41 . aid o| . Xmtak*
corrolito4 iltk wlM I*.
loiUoiu of tator OOM. aliaki
tllSIl! IISHIC; BIIIITIB Iktll!
•tint mis: mil »ici nnitn;
IIUTI mites
ICI (SO. « 09) II i»90«to4 iltk »ll»
•11 oieroto4 (Itklt 61 kr
30 Tt o!4 Hlo. «t 70 k9.
must Hsiiict nsmc ota u ic
ccitonosi nnii itcoiaiic
tifnisni oinnM utni foots;
ItllTS
nninc*
OOT9000. J.I.
71001 t. t.
Tootirloo. I.
IlflltO, 1.
1977
Tlf. C.-l.
3Mk. C.-S.
1*7S
larrlMtoi, J.B.
1144119k. J.F.
•orw. B.L.
loi**ortk, j.
ir»0
Croeollw, 1.1.
1*77
-------
Irseaic
7MO-38-2
la
Itf 7».»216. HP eii c it 28 ati, BP 613 C (anbllaes). TP 1 ea 89 at 380 C. 10 aa Bg at MO c
(COITIIOBO)
nssoB
16«8
Ortne
1669
Orlne
1670
Orlne
1S71
Brine
IXPOSORI BOOTS
Dereal
tngettion
Ingest Ion
Inhalation
iiiLTTicu.
BITBOD
-_
tadiosetrr
US
1 1 1
IOBBB1
or c»sss
9
6
a) 35
b) 22
c) «6
d) 28
el 32
a) 1
b) 1
c) 1
4) 1
•1 1
BUOE
a) < 10- 132 09/1
b) 12-28 ag/1
e) lot given
SO. 9-60. 2«
a) 10. 12-92*. 0 ag/dar
b) 5. 7-1 53. U ag/dar
e) 10.85-227.12 ag/dar
d) 10.96-280.8 ug/day
•I 3.05-38. «5 ag/dar
a) tot applicable
b) lot applicable
e) lot applicable »•-
d) lot applicable
•I lot applicable
mi
a) 61. t ug/1
b) 17.75 ag/1
c| <10 ag/1
57.9 » or - 1.5»
Bean » or - S.I.
a) 229.26 » or -
200.92 ag/dar
b) 70. «7 t ot - 38.18
ng/dar
e) 80.26 » or - 45.38
ag/dar
d) 63.07 * or - 56.71
ag/dar
e) 10.9 • or - 7.9
ag/dar
a) 0.97 ng/kg
b) 0.85 ag/kg
c) 0.30 ngAg
d) 0.12 ag/kg
e) <0.05* ag/kg
OtltllL IiroiRiTIOl
a) 5 dar* poat-exposnre
bl 10 dare poet-expoaare (6 of 9)
c) 19 dare poet-eipoMce
8 children, 1 adult (agee 5-38 rr> on
a tarn in loatralia.
Beaatarla. abdoninal pain, djaorU,
blood elote in ecine, Wadacbea.
BITUSt IKSIIICJ Oltlll BETU
fOISOHIO; CtSI HISTOlItS; JCTJLTS:
CHIIDBBI; IOSTHLII; rtlBS
1 ot done (*.9-11 oci Ie7« containing
appcoilaatel) 0.01 eg le) excreted
daring flrat 5 dare. Data aleo
available foe proportion* of rarioee
chealcal epeciee.
laaltnr »olenteere 28-60 yr eld.
6«-8« kg bodr "eight
IRtlSt (ISIIICl OIIIB: BIT1IOLISB;
CIII01
a) 3«3 ag/1 la drinking oatec
b) 123 ug/1 la drinking «ater
c) 48 eg/1 in drinking water
d| 51 ag/1 in drinking inter
e) <6 ag/1 in drinking inter
Itir and nclne level* reflected
Intake, blood levels did not.
tesldents, foe not <1 rr (average
renldence; «. 3 * or - 2.6 to 9.6 »
cr - 8 rr) , of 2 Cl and 3 IT
coaaanltle*. ivecego aget 26 » or -
15 to »» » or - 1* rr. 23-«3S
anokers.
BITILS; tISIIICt I11BI KILOnOI;
DIIIKIIG IITn; BLOOD; 01X11 1 Btlt;
CCBMIITITI ITtLDiTIOIS;
BIOICCQIOLlTIOli CiUFONIl; lITtOt
i) lorker >ho cleaaed drain
b) lorker vho clenned drain
c| otkec corker in viclnitr
4| otker norkor in vicinity
et sepervla-or
Inete herbicide gave rise to arelne
Beaolytlc a Dee la, renal failure.
vonltlng. renal lapalraent
iitiaoii: tisniCi tisinc OKIITC
COBPOOIDS; IIIBIk) BIOODJ IIUL9)
iisnciDisi IIDOSTIIU. iiDxcnii
iiDiiis; nun
nnuicc
la the*. E.
Stinton, B.C.
Patnaa. J.L.
1919
Tan, C.I.B.
charbonneaa, S.B.
Brrce, F.
Vonror, C.
Sandi. I.
1979
Valentine, J.L.
King, B.C.
splver. a.B.
1979
Parish, 8.G.
Glass, 1.
Unbrongk. I.
1474
din
u>
-------
ItMBle
7MO-38-2
II
Itl 7B.9216. BP 817 C at 28 at*. IP 613 C (BlbUa*al. TP 1 aa 89 «t 380 C, 10 aa Bg at MO C
(COITIID1D)
txssra
1672
Ori««
1673
Or !&•
BXPOSDBB 100TB
IIILTTICU
BBTBOD
n
BORBBI
OP C1SBS
.
»2
•1 1
bl 1
11*01
•) lot datactabl*
b) 0.01-0.05 ppa
c) 0,06-0. 10 ppa
4) 0.11-0.50 ppa
•) 0.51-1.00 ppa
f) 1.01-1.60 pp»
•) 2*. 1- 1650 09/2* ht
b) 21.8-180 ag/2» he
nil
•I lot •pplte«bl«
b) lot gl««
c) lot giv«B
a) lot 9i»«B
•1 lot gi»»n
f) lot glna
a) «6S.2 09/2* be
b) 250.9 B9/2* be
eiiiui XBTOBMTIOI
,
Bl 20 Of «2 CUM
bl 8 of *2 CBMI
C) 5 Of *2 CBM*
d) ( of «2 CIMI
•| 1 Of B2 C«M«
fl 2 of «2 CBMI
CilBu*-i«cb-li4ac*d km polacalBgi.
poiioalBg CB«M fcoB stBgBpon
a«B«CBl loapltal.
3}BptoBB India* bypccplgBvatBtloB.
BTpnk«CBto*l> of palBi »4 nlw.
ItplgMBtBtlOBI. pllBBB Bid flBBtBC
bTpBekUcoiii, iiltlpl* (EMBlcBX
kicBto**B OB teiBk Bad liBbi, lUa
CBBCOB* OB llBbl BBd tCVBk, blSBl
cill CBcelnoBB. BOMB"* dlBiuc,
tO«lC MBBOClBOtOE DOlTBMCOtBtBJ,
fin« fiagoe tnaoci. ckroaie
B*BdBCk*( l«tb*Cgr> WBkBBMt
iBBoiala, Beit* oe nbBcat* gavtrltl*
01 gBitcoiBtaeltli> «cit« to lie
kipttltiB, n toflcllBCy BBBllB.
BgmaoBi-call caiclnoB*.
iisnxc; am i itiis; onm IMODI
JIHlPOIBl 8RIL POISORIOl BTILS
a| (Malthr Bate. 6 laaplci owe 9 BO
b| EUiltky fiaal*. 2 Baaplvi 10 ao
apact
lldltloaal data atallaU*.
BITUSt TUCI SLIIBRS; IISIHCI
IIOBllBI CHCXOBi CBIOBIBB! COBUTl
CnORIOHl CI5XOII COPPBB; IBKOBIt
lOOIIEj POT19SIOH; BtlflllBSBi SOOIORt
I08IDXI8; sitBinat live; ot rat j
l»SOIB8Bn 8RBODS
SnSio
TBT. C.-B.
Soak. c.-S.
1975
Cocailii. «.
SBBBCkO, a.
BOBtB. J.
1975
bo
-------
IccwLc o»U« [»«203]
1*2-0}
91 19T.»2. BP 313 C (CUld«t it.) . 2*S c
nssot
16-M
Oclo«
Etr058tE WOTI
tfllTTICIl
firraoo
IOHBB1
or CUBS
•i to y
M 852
»KE
•1 M-S26 *9A
b) 6->-2U« «9/l
Utl
•1 220 tf/l
b) *40 19/1
CM til I mOIUTIOl
al 19TJ
b) 1«««-1fS2
Ocl»« «4*pl«« ttom »tfloj»9m of
coppm >Mltia9 plait 1» 11.
USniC; 01 HE; IBOtUSBS; SBLTEIS;
SBOKIIO; ItSIIMTOI; OCC1TV1TIOIU.
IIZ1I03
UPCUffCB
rlito, s.s.
e«5d«r»oo, f.
Eitociu*. r.t.
197«
ON
-------
1332-21-*
IUCT coirosraoi *raon 01
ii loo.o. at 1557 e
TZSSVI
1675
iifosm turn
I»9*stfc»
Zmbalatloa
IRIOD
or cms
•1 96
M 282
et 1*
4) 19
iun
•1 lot 91*01
bl 7. (2-10.05 ubutoi
bodl«*/20 em »•
cl Cot gl*«B
4) lot glvn
•I 15.55 asbosto*
bodlos/20 ca ••
M lot »l»«o
e) 77.7 ubMto*
baUo*/20 c« u
1) 17.1 ub«ato>
boAtu/20 c« M
ctiiui. iimunoi
•1 IT city •OB*»-di*4 196C-19SS
bf Dvlvth •OMB'^lod 19S3~1973«
l»9« of M«u
e| Ulu-llTCd wltki* 1/2 •!!• cmdlw
of aMBlto ub*«to* ftetocf la
IJ-dl*d 1951-1971
4| IT dty MB-Uod 1*C*-1«C(
TalMa foe deficit* ud probobl*
••bMtas bodi«>. Mta also mlltbl*
foe doflmit* asoMto* bodl** oily.
litopalos. BMB ag* it daatk, *9. 1
yc. lo rabjoct* oenpatloaally
oiposvd.
•5BI3TOS; LiMSt inn IK nut;
OCC*P»IOIII utues; coaruiriTi
iTuttnois; UTorsiB; snj lantst
ninioTi: in Jnsni in TVS
anmci
•MCbaek. O.
•aBBoad* K*C.
Sollkoff. x.J.
*ufc>, f.l.
laolo*, I.D.
OacfUkol. i.
H77
-------
Barbituric acl*. 5-<1-cTclohe»tem-1-yl»-S-ethyl- <» CD
2,«.6(18.3R.5R)-Pycl«141netcloM>.
-------
Bacbitulc >cl4. 5-(1-cycloh€l«n-1-7l)-l,5-aii«thrl- (8 CI) (Til)
].I,6(11.38.9B)-FTriBl41»«tllon«, 5- <1-cycloh«i«n-l-rl)-1,5-ai»«thyl- (9 CI)
16-29-1
C12-116-13-03
•I 236.26, It 145-147 C
TX3SVI
1677
OClM
•noson IOOTE
iag««tloB
llllTTIClt
BETflOD
ec
ac/as
IUHBEI
or cists
s
UME
>) tot gl**a
b) lot glvrn
c) tot gt»«n
4) lot glru
mi
•I < IS of 4on
b) 10 » or - 31 of
4o*«
e) 45 » oc - 12* of
dOM
4| 23 • or - «S of
ainui iiroiRiTioi
•1 ••sobacbltu
t) 3*-lr4roirk«iobicblttl
e| 3*-K«tok«xob4cbltal
41 I.S-OtMtkrlbarblttclc tcld
Ck«ile*U !• 48-kr pool«4 «rln« «ft«r
• 00-19
-------
Barbituric acid. 5-*Ujl-S- (l-aethrlbntvl)- (8 CI)
2,».«(18.t 3R,5R)-?vrlnldlnetrlone, 5- (1-aethvlbatyl) -5- (2-propenyl) - <9 CI)
C12-H18-I2-03
1« 331
TISSDB
1f8
eil«
1679
Blood
1680
Blood
EIPOSORE ROUTE
Ingestlon
Ingestlon
IIILYTICH.
RETROD
oc
GC
IORBE1
or cists
al 2
b) 11
c| 2
-n
•1
b)
e\
d)
e)
fl
BklGE
I) »2-->9 .9/1
b) 5-371 eg/1
c) 10-1)6 ag/1
0.1-165.0 ug/nl
a) 2.02-0.15 «g/Bl
b) 2.14-0.16 «g/nl
c) 2.12-0.07 ag/Bl
4) 2.1 2-0. 0« «9/«l
•) 2.21-0.15 ag/il
f) 2.19-0.13 «9/>l
HEM
a) 60. S 19/1
b) TT.6 19/1
c) 63.0 19/1
12.3 oq/al
a) lot applleabl*
b) lot applicable
c) lot appltcabl*
A) lot applicable
•1 lot applicable
(1 lot applicable
(«BIT
ClltltL IirOlfllTIOl
«) single btibitocic acid deiivative
ingested
b| TaUal (aeylobacbitoae t
qalnalbacbitone) ingeated
c) Onforaalated liitoces of
batbltecates Inge*ted
SceclieM collected at aatopiy
B)dcoirlated letabolltes «»«illr
ptoMnt in lo«et aionata than parent
dtag in flolda and tleaaec, and in
higher taonnti than parent dng in
• tine
Ethanol in torn* blood ipeclatni.
Vtoa a groap of 30 coroner'• caaesc
11-85 rr old vhere adiiniatratloa of
bacblttratei «•» saapected.
DIOGS; DIOO IBOSE; SEDITITIS;
XT180LITES; HBTIBOLISB; AOTCPStlS;
FOIEISIC RBDICtlt; BLOOD; BUB:
KIDIETS; tOISSs SPllElj DiliI; OIITED
KIIGDOR
Death canied by drag coabiaa. tiona
lecorde of 123« death* in 0. S. and
Canada. In all. dlaiepa* or it*
aetabolite «ere present in the
tliine* and, in aoct caaea, lore than
one drag eaa found, igess less than
5-greater than 65 jr. Blgk (reoaeacT
of aaicide. Other data available.
Valaonacj and visceral congestion
aost coaaoa postnortesi finding
DBO-JS; DIOG IBDSE; CtllDl; OIITED
ST»tBS; OTIB; SBDITITBS; HTPMTIC3;
esicaoTionc oioasi HOOD; inn:
IIDIETS; 11COI01IC BETBIIGES:
FOIEISIC HEDICIIB
a| Peak level-level at 108 hr
c) Peak level-level at 108 he
c) Peak level-level at 108 hr
d) Peak level-level at 108 he
e) Peak level-level at 108 hi
(| Peak level-level at 108 he
Individuals received single
therapeetic doses of 3.3 ag/hg.
Realthv sale volwteers.
BIOOD; BIOOD UISBIl DWOS; CSOO
tBIIIPT
tEMIEICE
loblnson. I.E.
IcDowall, l.D.
1979
rinkle. B.S.
RcCloskev. t.l.
Ooodaan. L.S.
1979
Clifford, J.I.
Cookson, J.R.
lickhaa. P.E.
197*
-------
BBEbita-lc add. S-allyl-5-{1-_-t_ylbBtyl)- (• CI)
2.«.6(1B.3B.5B)-FyEi_idiB«tcloB«, 5-<1-a«thylbatyl)-5-(2-pEOpaayl)- (9 CI)
76-73-3
C12-B18-B2-03
Bl 33*
TISSUE
16B1
Blood.
•BOl*
1682
Blood.
vkol*
1683
•IffOSOIB 100TB
Xn9
-------
Barbituric acid, 5-tllyl-5-(1-««thrlbotTl)- (B CI)
2,«,6(1!I.3B.SH)-Prrlaldlnetrlona, 5- (1-Bathylb«tyi)~5- (2-propanyl) - (9 ci)
C12-B18-I2-03
It 33a
(COITTIDBD)
TISSOB
168a
ll»er
1685
lung
1686
Spleen
EIPOSORE ROOT*
Ing* it Ion
Ingaatlon
Xngaatloa
IRILYTICIL
RBTROD
GC
GC
QC
BORBSB
or CISBS
a) 3
b) 13
e) 2
a) 3
b) 1«
et 2
al 3
b| 1«
0» 2
I1IOB
a) M-77 ag/kg
b) 5-339 agAg
c) «6-7» agAg
a) 20-34 agAg
b) 2-5* agAg
c) 1»-2« agAg
a) 30-150 agAg
b) 3-»5« agAg
c) 37-83 ag/kg
al
b)
c»
at
b)
c)
a)
b)
c)
57.3 agAg
66.0 agAg
60.0 agAg
27.0 agAg
18.8 agAg
18.8 agAg
73.7 agAg
69.1 agAg
60.0 agAg
GBKML IIFOBRHIOI
a) Singl* barbituric acid torltativa
ingaatad
b) tolnal (aarlobarbltona t
golnalbarbltona) Ingaatad
cl Oaforaalatad alitaraa of
birbltarataa lagaatad
Spaclaana colUctad at antopty
Bflroirlatal aatabolltaa aaaallr
Btamnt la loaar aaoants tbaa paraat
4»g la (lalds and tlaaaaa, aad In
kighar aaoanta than pacant drag In
aria*
Bthanol In aoaa blood apaclaana.
Ftoa a groap of 30 coroaar'a CBMB,
17-85 yr old, vbara aialnlitratlon of
barbltaratai •»» aaapactad.
OI03S; DIOG IBOSB; SBBlTIfBSj
BIT4BOLITB5; HBTiBOHSB; iOTCTSIBS;
rClBISIC RBDXCIIBi BLOOD; Bill;
IIDIBYS; 10BOS; SP1BBI: OBIII; OIITBO
IIBOOOI
al Siagl* barbltarlc add d«rl«atl*a
lagwtad
b) Toiaal (aaylobarblton* (
lalaalbarbltooa) lagutad
c) DBforaalatad alxtuaa of
barbltirataa Ingaatad
Sptclaana collaetad at aatopay
Bydroirlatad aatabolitci aaaaily
pia«BBt in loa«r aaoant* than parant
drag In tlalda and tlaaaaa, and In
alghar aaoaata than parant drag la
aria*
Bthaaol la BOB* blood apaclaans.
Froa a groap of 30 coroaar'» ci
17-85 ft eld, «kara adainiBtratloa of
barblticatcB «aa aaapactad.
GBOGSl DIOO IBOSB: STO»TI»B3;
BltlBOtltES: 8ET1BOLISB; IRCPSIBSI
fOHISIC BBCICIfB: HOOD; BIU:
(iDiiTS; loans; stun: otiiu OBXTBD
KIBODOH
a) slagla barbltarlc acid daclntlTa
Ingaatad
b| lalnal (aarlobarbitona I
galnalbarbltona) lagaatad
c) Onforaalatad alitaraa of
barbltarataa Ingaatad
Spaclaaaa collected at aatopaj
BTdcosylated aatabolltaa aaaallj
praaaat IB loaer aaoaata than paraat
drag In tlalds and tlaaaaa, and In
hlghar aaoaata taaa parent drag IB
arlna
Btkaaol la aoaa blood apaclecia.
Froa a groap of 30 coronar'a caeaa,
17-85 rr old. «hera adalnletration of
barbltarataa «aa aaapactad.
OIOOS; DIOG kBOSI; 3KD1THB3;
RttlBOLITIS; IBT1B01ISRS
FOIBISIC IBDICXII: BLOOD; Bill;
IIDBBTSl LOIOSl SFLBSli OBIIIl OIXTBO
IIIODOH
(BBR »OB)
lobloaon, I.E.
RcDoaall, I.D.
1979
Boblnaon, t.B.
RcDovall, I.D.
1979
loblaeoa, I.E.
BcOorall, I.D.
1979
-------
Bacbltaric add. 5-«UTl-S-(1-««thyU)«tyl|- (8 CI)
I.«.6(1R,3R,m-FTElliain«triOM. 5- (1-l«thTlb»tjrl) -5- (2-prop»BT«- (9 CI)
C12-B1S-B2-03
ai 33*
(CORIIDBD)
cxssoa
1687
Ociae
anoaoaa aoon
Ingectloa
IIILRXCll
BRIOB
OC
BOHBII
OF CUB
a) 3
b) 10
IIIOI
al 3-32 agA
b) 1-5 ag/1
""aaia
at 13.7 ag/1
b) 2.7 ag/1
CBBBBal IBFOIB1TIOI
a» Single baibUacie acid declraUn
lnge>ta>d
b| TBlaal (aijlabarbltoie »
qelsalbarbltoaa) laoHted
Spedaaaa collected at aatop«r
BydtasTlBtBd Betabolltea anally
pt«MBt IB lOHar aaOBOta tlBO parent
drag IB flalda aed tlanea, and IB
klgbac aaoaats than patent dcag la
aclne
ttkaaol IB Boae blood apeclana.
IEOB a gcoap of 30 coroaer'a caaea.
11-85 yc old, nkBce adalnlatEBtlon of
bacbltacateB mm aupected.
DIMS; Dine taosai aaoMirisi
BRIBOIITBS: BBTHOLXSli 10ICfSH3|
roiaaaxc BEDXCIBBI BIOODJ axuu
KIDIBTSI toags; spun; onaij DBITBD
iiiaooR
ai^BkBHCB
Sobinaoa, t.a.
BeOoBBll, B.D.
1979
-------
Barbituric act*. S-»thyl.-5-{F-hT*«»TPh««>TU- (B CI)
2.«.6(1I,31l.SB)-PrrlildU«trlon*. S
319-3«-0
C12-al2-»2-0«
HI 2(8.26
CI)
TISSUE
1688
Orlm
BXPOSOBB BOOT!
Ing* it ion
aBatTTICIL
HBTHOD
OC
BOHBBB
OF CtSBS
3
B1BGB
a) 3.9-8.2 19
b) 1S.«-39.7 19
'
'""
al 6.3 ag
b| 25. » 19
GBIIIIL IirOIBlTIOl
a) 5 day* aft*r 30-19 do»
b) S daj« a(t«r final do»«, 30 aq/dar
for 21 day*.
3 hultkr ial«», a9M 23-21 jr.
DBOOS: DBOO TRBBIPI; SISCOISH;
1 CULTS; 81000 SBBOB) 3BD1TITIS;
OBIIBI ITPBOtlCSl BBTaBOUIBS]
altlCOITalSIBTS
BEFBBSICB
»i««Mthan, C.T.
Bookar, B.E.
1979
-------
Barbltarlc add, 5-ethyl-S-(t-eetaylbatyl|- (t d)
2.>,6(1H,3I.SH)-Pycialdlaetrloae, 5-ethyl-5-<1-B»tkylb«tyl)- (9 Cl)
76-7«-»
C11-818-12-03
Bl 226.31
nssoi
1689
Bile
1690
Blood
1691
Blood
1692
Blood,
vkole
•nosvii toon
Ingeatloa
Injection
UllTTIClL
BBTIOB
OC
laaonoeniyaatlc
0»
IOBBII
or cists
al 3
b) 1
. .
51
1
UMB
B) 59-152 ag/1
b) lot applicable
lot given
2.0-157.0 «g/Bi
lot given
(HIT
nil
a) 119.7 ag/1
b) 138.0 ag/1
1«70 ag/100 al
23. C ag/al
a. 5 ag/dl
PtGB)
•IIIUL IIIOIUTIOI
a) Slagle barbltarle add derivative
lageated
b) Onforaalated alxtorea of
barbltaratea ingeatod
Spedaeaa collected at aatopay
Bydrozylated aetabolltu anally
preseat IB lower aaoaata than parent
drag U field* and tl»aaee, and U
hlgkor aaoenta than parent drag la
grlae
Itkaaol la 1 blood apeclaen.
tcoa a gcoap of 30 coroner 'a cas*«.
17-85 yr old, "here adalniatratloa of
barbltaratea «aa aaapected.
DIOOS; DlOg MOSB; SBDITITBS;
ITTaBOLITIS; ItTMOLXSI; IOTCPSXU;
POinSIC IIOICXIBi BLOOD; BI1B;
HDiiTSi loiosj spLin; omit OIITBD
inaooi
Totlcology ca»e
DIOOS; BItll Utll; Lim; KIOI8TS;
BIltBPlBS; BLOODj BBISOHHIII BBTBODS
Death caaaed by drag eoablnatlon
tecorda of 1239 deatka la 0.9. and
Canada. IB all, dlanpaa or Ita
aatabollte vere preaent IB the
tiaaaes and, IB aoat caaei, lore thaa
one drag aaa foaad. >gea: leaa thaa
^-greater than 65 yr. Hlgk fregaeacy
of aaleld*. Other data available.
Palaoaary and vlacaral congeation
aost coaaon poataortea f lading
DIOOS; DIOO MOSB; CilaDl; OUTTO
SIlTES! OtlB; SBDtTIVES; ITPWTICS;
•SIC8OTIOPIC DIOBS; BLOOD; I IT El;
IIDIBTS; I1COIOLIC BBTBllOBSt
FCIBISIC BIDICIIB
Ceataortea aaalyala after I.I.
aelf-adalnlatratloa of at leaat ao al
of agent coaposed of 26 g
pentobarbltal, 13 g aaobarbltal, 20
al laopropanol, 10 al polyethleae
glycol-200, dilated to 100 al «ith
B!0. Orag not detected IB urine or
gaatrlc conttata
Tiaaae troi Injection alte contained
0.1 ag/dg aaobarbltal, 0.* ag/dg
peatobacbital, and laopropancl.
20-yr-old, 90 kg, caacaalaa aale.
lateaae acate congeatlon of all
oigaaa.
DIOOS; DB08 IBOSB; SOICIDB;
• OTOPSIBS: BIOOD; BIIII; XIDniS;
IITBB; TITIIOOS BOBOl; BklTlMO
nrnnci i
1
loblaaon, 1.1.
BcDovall, I.D.
1979
Sllgktoa, B.L.
1978
Flakle. B.3.
BcCloatay. K.L.
eoodaan, t.S.
1979
Clark, B. a.
Jonea, J.I.
1979
Ul
-------
garbltarlc acid. 5-ett>Tl-5-(1-aethylbatrU - (8 CI)
2.«.6<1H.3H.5H|-PTrlaidlnetriona, 5-«thyl-5- (1-aathylbotrll - (9 CI)
C11-B19-I2-03
HI 22«.31
(COITIIOED)
TISSDB
1693
Blood.
vhol*
169*
Brain
1695
Sidney
BXPOSDBB BOOTH
Ingeatlon
Injection
iBJaCtiOB
IIILTTXCU
BETBOD
OC
Ot
Dt
IOIBEB
OF CISBS
•1 3
b) 1
1
1
BUGS
«) 10-51 ag/1
b) lot applicable
(ot glT*n
lot gltan
al
b)
a.
2.
al 28.7 if/1
15.0 19/1
a. 8 ag/dg
2.6 ag/dg
OEIIIIL IIFOfBlTIOl
•I Slngla barbituric acid darlfatlt*
b| nnfor«al«t«d Blituu of
barblt«rat«< iaf««t«d
MU coll«ct«d at aotopiy
Mtabollt** anally
;c«««nt In loner aaopot* that parant
drag in floldi aid tlaaaas, and la
blgkac a«o«nt« than patent drag la
(tin*
Itkwol IB 1 blood ip«cla«n.
Ttoi a 9COIP of 30 coroner'* caxa,
11-85 jt old. «k«r« adalnlltratlon of
bacbltaratoa •«• aupoctcd.
DlOOSj DIDO 1B03E; SEOITITES;
IttMOLITSSt HET1BOLISB: aOTCPSIBS;
FCBBI3IC tlECXCXIBt BLOOD; BIIE;
IIDIBTS; 1010S; SPlEBij OBIIIl 01 I TED
IIIODOB
Fcitaactaa aaalrala aft«t I.I.
i
-------
Bacbltaxlc acid, S-«thyl-5-<1-B«tkrl*«tyH- (8 CI)
3,«,6(1B.3R,5B)-FyrlBidln«tcloB«, S-ethyl-5-<1-B»ttylb«tyl)- (9 CD
76-7«-»
C11-B1B-I2-03
II 226.31
(CORIIOED)
nssoi
1696
lidney
1697
Unc
1698
ll»atc
EXTCSOBB IOOTB
lagaatioa
Injection
Inge at Ion
allLYTXCU
HBTHOD
GC
or
GC
IdBBBB
OF CUBS
•1 3
b) 1
1
al 3
b) 1
UTCB
a) 15.5-59 agAg
b) »ot applicable
lot glTen
a) 20-165 agAg
b) lot applicable
(IEXT
ran
a) 33.0 agAg
b) 71.5 agAg
2.0 ag/dg
a) 77.0 ag/kg
b) 133.0 agAg
MSB)
OIIBUL IIFOIMTIOI
a) Slagla bacbltaclc acid dacltatln
lageated
b) Daforaalated alitacea of
barbltarataa ingeatad
SpactMa* coll«ct«d at aatopar
Rydroxrlatal a«tabolit«a uaally
pcaavnt IB lomr aaoaata tbaq paraat
a rag la (laid* and tlanaa, and la
klgbar aaoaats tkaa parant drag IB
QClcW
Itkaaol IB 1 blood apvdaan.
Tcoa a gcoap of 30 oocoaac'a caaaa,
17-85 yc old, nhara adalnistratlon of
bacbltacat«a •«» •upcctad.
BIOOS; DIDO UOSEt SBOlTIfBS;
imBOltTESt IBTaBOLISI; lOTCPSIBS:
FCBBISIC gieiczii; BLOOD; BIIB;
HOIETS; lOIOS; SflBBI; OBIIIl OIITBD
ITIODOI
Peataottaa aaalyala attar I.f.
a«lf-adBiBi«ttatioB of at leaat «o al
of agant coapoaad of 26 9
paatobacbltal, 13 9 aaobacblUl. 20
al iaopcopaaol, 10 al polyatblaM
o.lycol-200, dilatad to 100 al «Uh
830. Do«g not datactvd la aclaa oc
gaatclc coatanta
Tiaana froa lajactlon ait* ccntalnad
0.1 ag/dg aaobacbltal, O.I ag/dg
pantobacbltal, aad laopcopancl.
JO-yr-old, 90 kg, caacaslaa aal*.
latanaa aeit* congaatlon of all
ocgaaa.
OlOOSl 0110 IBOSBi SOICIDB;
10TOPSIBS: BWODJ BIUI| IID1ETS!
VITItOOS BDBOI; BUHMD
a) Singla baibitacic acid daclfativa
iagaatad
b) Dnfocaalatad alxtacaa of
bacbltarata* Ingaatad
Spaclaana collactad at aatopiy
lydcoxylatad aatabolltaa aaaally
pcaaant la lo»ar aaoaats tkac paraat
drag In flaida and tlaanaa, ind la
atabac aaoaata tbaa patent dng IB
grlna
Itkaaol la 1 blood apaclaan.
(COB a gcoap of 30 coronar'a caoaa,
17-85 yc old, ukaca adalaUtcatioa of
tacbltacataa vaa agapectad.
DIOOSl 0108 HOSB) SBDITITBSj
gniBOLITBS; IBTkBOLISR; lOTCPSIBS;
roBBisic geoiciiB; BLOOD; BIUU
IXDIBTSl tOiOSj SniBUi 01X11; OIITBD
ITISDOR
lopinaon, t.B.
BcDovall, I.D.
1979
Clack. 8.4.
Jo»a, J.I.
1979
loblaaoa, 4.B.
BcDoaall, I.D.
1979
-------
Barbituric acid. S-ethyl-5-(1-sethvlbatvl)- (•> CII
2.«,6(ia.3R.5f!)-Brrlaidinetrione, 5-»thyl-5- (1-nethylbatyl)- (9 CI)
C11-H18-12-03
HI 326.31
(COITIIOED)
TISSUE
1691
Lanq
1700
Spleen
1701
Urine
BXPOSOBB ROOT*
Ingestion
Ingest Ion
lagestion
amnicai.
BITBOD
GC
SC
GC
•DBBBB
OF CISIS
a) 3
b) 1
« 3
b| 1
3
SHOE
a| 29-72 ag/kg
b) lot applicable
a) 32-61 eg/kg
b) lot applicable
_
5-C2 ag/1
(•Bit
Rial
•1 M.8 agAg
bl 35.5 agAg
a) «1.7 agAg
b) 72.0 agAg
2*. 7 eg/1
paon
GEItBll XIFOimiOl
a) single barbltaric acid derivative
Ingested
b| Ontoraalated aiitores of
barbitaratea Ingested
Specisens collected at aatopiy
Bydroxylated setabolltes asaally
present in lover aaoants than parent
drag in flalds and tlssoes, and la
higher aaoanta than parent drag in
arise
Ithanol In 1 blood apeclaen.
Froa a groac of 30 coroner's cases.
17-85 yr old, vbere ad sinlst ratios of
barbitaratea vas sospected.
DBOOS; DIOG »BOSB| SEOITIfBS;
imBOLITBS; BBT1BCLISB: aOTCPSXIS;
FOI8ISXC BBOICIIBJ BLOOD; BIIBl
HoiEts; loies; SPIES*; oixii; OIITBD
(XIGDOB
__
a| Single barbltaric acid derivative
Ingested
b) Ontorealated sixtexes of
barbitaratea ingested
Speclaens collected at aatopiy
Bydroiylated aetabolltes asaslly
present IB loeer aaoants than parent
drag in flalds and tlssaes, and la
higher aaooats thaa parent drag In
erine
Ithaaol IB 1 blood apeciaen.
Froe a groap of 30 coroner's cases.
17-85 yr old, vhere adalnlstratloa of
harbltorates las saspected.
Diaos; DIBS IBOSB; smanfis;
BITIBOtlflSl BBTtBCLISB! tOTCTSIBS!
FOIEISIC BBCICIIEl BLOOD: BIIBJ
IIDIEIS; LOIOSI SPUIt; OIXHl OIITCD
KIIODOR
Single barbltaric acid derivative
ingested
Specimens collected at aatopay
Bydroxylatad metabolite asaally
present IB lover amoaats thai parent
drag in flalds and tlssess, and IB
higher aeoaats than parent drag is
arlne.
Fros a groat of 30 coroner's cases,
17-85 yr old, vhere adalaistratlon of
barbitaratea eas saspected.
DBOOSi D106 IBDSI] SBMXfsSI
inaioufist Htuoiisii amctsxts:
FOIEISIC lIDXCini IIOODJ BIIBJ
iiDiBTS; tmosi spum oixiii onTio
IIIODOB
BBFIIEICE
lobiason, a. I.
BcDovall, l.D.
1979
_
•obinson, a. I.
BcDovall, l.D.
1979
loblnsoa, a. I.
BcDovall, l.D.
1979
00
-------
Batbltvic acid, 5-*tkrl-S-(VMthrlbBt7l|- (S CX)
2,«.«(1I,3B,5R)-PyrlildU«trloi«. 5-«thyl-S-(1-««tkylbutrl|- (9 CI)
C11-B1B-I2-03
It 226.31
(CORXialD)
nssoB
1102
Tltnois
kaior
snosoBB lonn
iBjCCtlOB
kutnzcu
BB1BOD
or
— iaiiii —
OF CIStS
1
UKB
-
lot gi*«n
HUI
.
2.0 l»/dl
8BIEUL IBFOBI1TIOB
Fo«tiact» ualyci* »ft«r I.T.
mie-aliiniBtntioi of «t l«at «0 •!
at >g«Bt co«po««d of 26 g
(Wltoblrbltil, 13 g uabacbiUl, 20
•1 l«opropanol, 10 il polr*tU«M
glrcol-200. dlloud to 100 il »ltk
B20. Dcig not 4«t«ct«d la idi« or
gictetc eoBtots
Tl«>a« (cot l*j«ctlo> «lt« ccattin«4
0.1 ig/dg aiobacblt*!, 0.* ig/lg
p«atob(cbit(l, and l«opcop»cl.
JO-fr-old, 90 kg, Caocuiu nl«.
Iitcni* «c«t« eoigutloi of «11
ocgua.
HI DCS; 0100 IBOSB; SOICIDB]
lOTOPSIHS; BlOODj BBtlB; KIDniSj
IXTBBi TITHOOS BOB01) BIBTLIBO
BBTBUBCB
clack, B. ».
Joofm, J.I.
1979
\o
-------
Barbituric acid, S-ethyl-5-iaopsntYl- (8 CI)
2,a,6(1B, 3B.5B)-PrrUidln«trloiie, 5-ethyl-S-(3-sstujlb»tTl)- (9 CI)
C11-B1B-B2-03
81 226.27. i( 156-158 C
TISSUE
1703
Bile
noa
Blood
1705
Blood.
•hole
CXPOSOBB BOOTC
Xngestion
Injection
IIUTTIC1L
HBTBOD
QC
or
HOBBSB
OP CISES
*) 2
b) 11
c| 2
26
1
BaBGE
a) 178-198 sg/1
b| 13-531 «g/l
c) 1M-365 S9/1
1.5-182.0 ag/il
lot given
(HIT
BE1B
a) 188.0 19/1
b) 125.6 19/1
c) 256.5 sg/1
20.8 »g/al
0.2 sg/dl
riGR)
GEBEBtL IBFOIBITIOB
• 1 Sligl* b*iblt«clc tcld 4«ctntl*«
iD9*«t*d
b) I«ln«l (nrlotwrbltoD* s
qaliwlbicbitoM) Ipgutcd
c) Dnfocialat«4 liitoccs of
bacbitacatci lt>9ut«d
SpvclnM collvctod «t aatopij
Ifdroiflatid ••tibolit** anally
Ft«Mot In lone anmta thai parent
dc«9 In fl«14» aid tlMOii, and in
bighor aaoont* tban ptraat 4 to 9 In
ocln*
Bthanol In ion blood ipcciaoi.
fcoa a gcoip of 30 cocon«c'« caa*>.
17-85 re old, »••!• adilnlitcatlon of
bacbltacataa laa Bup«etod.
CIOOS: DBDC aBDSBi SEOaTITES;
amBOHTES; BBTiBOtISS; lOTCVSIBSi
fCIBVSIC BBDICIIB; BLOOD; BIIB;
IIDBBIS; LOI8S; SPIBBI; 01 IB!: OBITBO
IIBODOB
Daatb caa««d bf dc«9 coabina lions
B«cord* of 1239 taath* in 0.3. and
Canada. In all, dlazvpai or it*
•atabolit* «•!• pc«Mat ia tha
ttaiaas «nd, in ao«t can*, aor« than
OM dc«9 MI fo«d. tg*>: !«•• than
5-9t«at»r than 65 jr. Bigh (r*9a*ncr
of *aicid«. Other data available.
••lionacT and *l«e«ral coagvitlon
aoit coaaon ;oataoct«a fiadlBo
DBOQS; DBDS 1B03B: CtBlOl; OBXTBD
STUBS; OTaB; SBD1TITBS; BTPBOTICS;
rSTCBOTBOflC DBOOSl BLOOD; 11TBI;
IIDBBIS: IICOBOLIC BB»B1»OES;
fOIBBSIC IBDICZBB
foatnortan aaalyala after 1.1.
aalf-adalnlatcatioa of at lent «0 al
of ag«nt coipo>*d of 26 9
E>«ntobacbltal. 13 9 aaobatbital. 20
al iaopcopaaol, 10 al polntklcM
9lTool-200, dilated to 100 al with
B2o. Dng «ot detected in mtine or
gastric contents
Tisss. fron injection sit* contained
0.1 sg/dg aaobatbital, 0.« «a/dg
peatobarbltal, and IsopEopancl.
20-yr-old, 90 kg, Caocasian sale.
Intease ac«te cosgatlos. of all
organs.
DBOBSl DBOO IBOSB; SOICIDB;
lOTOPSIISl BLOOD; BBUBi IXOniS;
IITBI! TXTBIOOS BOMB; RIBTLUD
BEfBKfCE
Boblnson, >. E.
HcDoiall, B.D.
1979
rlnkle, B.s.
BcCloekey, K.I.
Ooodsan, 1.3.
1979
Clark, fi. 1.
jones, J.I.
1979
-------
larbitarlc acid, S-ethyl-5-l*opentyl- (8 CI)
2.a,6(1l.3l,SR)-PyrlaldlBatriono. 5-etkyl-S-(3-nethylbatyl|- |9
ST-B3-2
C11-H1B-I2-03
Bl 226.27. at 1SC-158 C
(COITXfOID)
TISSDI
1706
(load,
•hole
no7
Brtii
1706
Kidney
~
inonu IOOTB
IngeetiOn
Injection
Injection
1IILTTICU.
IRBOD
OC
UT
or
mm
OP CMBS
•I 3
bl 1»
C» 3
1
1
lalQB
a) 25-36 mg/l
b) 3-19 eg/1
c) 7-17 19/1
lot glfen
lot given
(lin
mi
a) 32.0 ng/1
b) 9.9 my/I
c) 10.7 mg/l
0.2 mg/tg
0.5 mg/tg
P»0f|
IIFOIUTIOI
n) Single bacbitarlc acid deritatlTO
lngrat«4
b| TUnal |»rlotarbiton« 8
qiinalbarbitoml ingutvd
c| Onfor»l«t«d iixtir«« of
bntbitacat** ing«it«d
Sp«cin«n« collected it utopiy
lydrairlatid netnbolite* nmillr
pcieent In loner *nowt* thnn parent
ing in (laid* and tlMW*. and in
nigner anonnte than parent drag in
nrlne
Itbaaol in aone blood specinenn.
rron a groap of 30 coroner •• ca*w.
1V8S rr old, Khere ad Bin Ut ration of
barbltnrate* •»• eupected.
0100 MVSBi 3IDtTITBS:
imtOLItBSi RTlBOIISIt lOTOPSIBSl
FOISI3IC IBOICIIBt BLOOD; Bill!
IIDIBIS; LOI6SI SPLBBI; OBIII; OIITED
IIIODOI
feataorten annlyaia after I.I.
aelf-adainlatratlon of at lent 10 nl
of agent coepwed of 26 9
pentobarbltal. 13 g aaobacbltal, 20
al iaopropaaol. 10 al polyetnlene
glycol-200, dilated to 100 el Kith
B2O. Oreg not detected in ndne or
gnatrlc content*
Tieene froi injection eite ccntained
0.1 mg/tg anobacbital. 0.* mg/tg
pentobarbltalt and iaopropanel.
20-yr-old, 90 kg, Caacaaian iale.
Intenae acote congeetlon of all
orgaaa.
DI003; D10S IBOSI; SOTCIDB)
10TOPSIBS; B100D; BBUI; KXOBBTS]
HTM) TITI1QDS IOBOB!
Ccatnorten annlyaia after I.'.
aelf-adalniatratloB of at least ao al
of agent couponed of 26 g
pentobarbltal, 13 g aaobarbital, 20
al iaopropaaol, 10 al polyetblene
glycol-200. dilnted to 100 nl vita
120. Drag aot detected in atine or
gaatric contenta
Tiaaae fcoa Injection alte contained
0.1 mg/tg aaobarbital* 0.* mg/tg
pentobarbital, and laopropanol.
20-yr-old, 90 kg, Caacaaian tale.
latenaa acnte congestion of ill
otgana.
DIOOSl 0100 tBOSB; SDXCIDB;
IOTOPSIBS; BIOOD; nail; (XDIBIS:
IITEB; TITBBOOS ROBOB; RiBTlMD
BBTBBBICB
loblnaoa, a.s.
BeOovall, I.D.
1979
Clark, B.I.
Joaea, J.I.
1979
Ui
Clark, B.I.
Jones, J.I.
1979
-------
Bacbltarlc acid, S-ethrl-5-lsopentrl- (8 CI|
2.*.6(1H.3R.5H)-P7Cinldlnetrione. S-etkrl-S-(3-eethrlbatyl)- (9 CI)
C11-B18-B2-03
Hi M6. 27. at 156-158 C
(CORTIROBD)
TISSOB
1709
Kidney
1-MO
li»c
nil
ll»er
BIPOSOBB BOOTH
Ingestion
Injection
Ingestion
IBILTTICH
HBIBOD
oc
at
oc
ROHBBB
OF CiSBS
•1 3
b| 11
C) 3
1
•13
b) 13
c| 3
BUGS
•1 32-87 eg/kg
b) 6-12* eg/kg
c) 8-23 sg/kg
.
lot giren
a) 71-22« sgAg
b) 7-228 sg/kg
c) 15-71 19/119
(IIR
sen
» 59.1 ng/kg
b) 30. « ng/kg
c) 22.8 ng/kg
0.2 ng/dg
•) 12*. •» sg/kg
b) 60.* sg/kg
c| »».7 . jAg
MOB)
CBItBll IlrOBHlTIOI
•I slngl* bacbltoclc acid 4«cintlT*
b) Talaal (»rlob*cbitan« (
ItilntlbacbltoM) lagMtcd
ct nnfoc«l«t«d ititac*B of
bacbitac*t«« lngut«d
S;«C!MII collected «t aatopiy
Eydroiyl>t«d Mt«bollt«« Moilly
FMicit In lone Meant* thnn puent
dci9 In fields «nd tl»«o««,
-------
Barbitarlc acid. S-etkyl-5-leopeatyl- (8 ci)
2.*.6(1B,3B.SB)-ryriBldlBatrio[>o, S-etkrl-5-(3-netkylbatyl|- (9 CI)
57-M-2
C11-118-12-03
•I 226.27. If 156-158 C
(COirilOED)
TXSSOB
ma
1713
SplMft
Oclae
B IPO SO11 BOOTB
Ingeetloa
Itg^Btion
Ing* it ion
iiumcu.
BRBOD
oc
oc
IOBBBI
OP CUBS
,
a) 3
b| 1*
cl 3
a) 3
b) 1*
c) 3
2
BMBB
a) 39.5-83.5 ng/kg
bl 3.5-56.0 agAg
c) 6.5-18.5 egAg
a) 63-10* agA9
b) 5-3*5 ngAg
e) 6-3* ngAg
a) 0.8-1.6*
b) 31.6-»6.8*
c) *.5-5.5*
(KBIT
ran
a) 55.3 ngAg
b) 20.6 ngAg
c) 13.0 eg/kg
a) 81.3 ngAg
b) 55.2 ngAg
e) 21 ngAg
a) 1.08*
b) 39.3*
c) 5.05*
PtCE)
CIltltL I1POBUTIOB
a) Single barbituric acid derlMtive
Ingested
b) ninnl (anrlobarbitone S
e| OBfornelated alitarea of
barbiterates ingested
Spocisen* collected at aetopiy
Bydroxylated netabolitea ueally
present in lone aaoants tknn parent
drag in flaida and tissues, and IB
higher anonnta tkan parent drag in
•rlne
ttkasol IB none blood specisans.
Iron a greap of 30 coroner** case*.
17-85 yr old ikere adaiBlatratloa of
barbltoratea aa* nspected.
DIMS; D100 aBOSI; SBDITITBSt
BRlBOLITBS; BBtlBOLXSBl lOICPSIBSl
poBEisic RiDiciii; BLOOD; BUB:
IIOIBTS; lOBSSj SUBEIj OBIBll OIITBD
KIIODOR
a) Single barbitnrlc acid deiivatln
Inge* ted
b| Teinnl (aeylobarbitono 8
qvinnlbncbltone) ingested
c) Oafornnlated nlxtnre* of
barbltacnte* lnge*ted
Spaclnene collected at nntopir
Bydroxrlated aetabolitu aaaally
present in lover aaoant* that parent
drug in field* and ti*aaa«> and in
klgker anonnt* tkan parent drag in
arine
Bthaaol in aoae blood *pecinaa*.
froa a gronp of 30 coroner's caeas.
17-85 yr old, «kere adeinletratloa of
barbitirate* >a* *a*pected.
DBOGS; DROG IBOSBj SBBITITBS;
IRkBOUtBSi 8BTIBOLISB; kOTCPSIBS;
POBB1SIC B1DICIIB; BLOOD; BIIE;
IIDBBTS; 10BOS; SPIIBI; OBIIf; IIITBD
KI10DOH
-
at knylobarbltone
b) 3>-lydroxy-aetabollte
c| 3'-Carboty-aetaliollte
« of done, 96 br after 200 eg. 3
trial* par aabject. level* declined
aonoexpoaentially op to 8* ki.
1 haaltky *cloata*r*
DIOOS! BBTlBClISB; OBI IB
UP11BICB
BoblBCoa. l.B.
BCDOMll, I.D.
1979
Boblason, l.B.
BcDOMll, B.O.
1979
Baldw. B.C.
Gilbert. J.B.t.
FO¥«U, J.I.
1979
Ul
oo
-------
Barbiterlc acid, 5-ethrl-5-l«opentTl- (8 CD
2,«,6 (111,38. 5R)-Prrlnldinetrione.
51-0-2
C11-HH-I2-03
«i 226.21. HP 156-158 C
)- (9 CI)
(COITIHOED)
TISSUE
1115
Orlne
IIPOSOBE BOOTS
Inflation
ilaLYTICll.
KRTB.OD
GC
""
HOB BIB
or CISBS
t) 2
b) 11
c» 2
RklOB
•I lot applicable
b) 1-12 ig/l
c) 11-18 19/1
mi
..
a) 12.0 ig/l
b) 5.3 «»/!
c) 1*.S ig/1
C1IEUL IirOIRtTIOl
•) Sittgl* baibltncle acid 4«tlfatl*«
lng«it«d
b) Tiinal (acrlobacbitan* t
qoiaalbicblton*) inqaatcd
c) Onforial*t*i ilitarci of
tubitiratci lag«*t«4
Sp«clMni collected at aatopay
BydcoKTlattd ••tabolltu aaaallr
pc«MDt In lover amount* tbao parent
drag in tl«Lds and tlaiui, and in
liiaher anoqots tkan parent dreg In
urine
tthanol in
-------
Barblticic tola. S-etkyl-5-pbenyl- (a CX)
S.»,6(1S.3B.Sat-PyrlBiaiaetrlone, S-etayl-S-pkenyl-
i0-06-6
C12-112-12-03
II 232.23, HI 17«-178 C
TI3SOB
1716
BUe
1717
Blood
1718
Blood.
plain
17H
Blood.
plasaa
BIKSVBB IORI
Ingest Ion
Insertion
Injection
__ .
inimciL
•MOD
OC
laaonoanxyaitlc
GC
laeanoeuyaatlc
Bnsyeatlc
IOBB1B
OP CISBS
1
•1 1
b| 1
e) 1
41 1
•1 1
8
UNI
lot applicable
lot given
•I lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
e) lot applicable
a) lot given
b) lot given
c) lot given
(IEXT
IBII
1.0 ag/1
8600 ag/100 al
a) 80.2 ng/al
b) 2S.2 ng/al
c) 7.3 ag/al
d) SO. 7 ag/al
•1 15. 5 og/al
a) 20 ag/1
b) 37 ag/1
c) IS ag/1
PIOBI
BEIIUL IIPOIBITIOI
Oaforaalated alztare of bacbltacatee
Ingested
Spaclaeu collected at aatopiy.
Pros a gcoap of 30 Conner's cases.
17-85 jt old. share administration of
barbltacatea eas aaapectad.
HOBS; DIOO IBOSli SIDitlflSt
IR1BOLIIB5; snaBousa; tncpsnst
FOMISXC IIOXCXIII BLOOD! BIIBJ
inistst taios; a?iBHt oini; OIITBO
1118 DOB
loilcology caee
0100S! BItB; BMIli lITBIi HDIBTSi
OIISEPIIS; B100DJ BBUDBIBBIl 8RIODS
a) 7i yc old aan, aalclde
b| 27 vc old raian
c| S ye old girl, epileptic.
aibtnarapeMlc levela of
dlphearlaTdaatola aleo foaad
d| 5« yc old aan, poattraaiatlc
•[llepar, prevlou aalclde atteapt
e) 5« yt old aan. oapceealf*
aiadroae, blood alcohol level 2.98
9/1
111 died of acute Intoilcaticn fcoa
coabloatlon of paeoobatbltal and
flacasepaa.
Deep coat, caidloclccalatOEy
collapse, shock, coaplete araClexla.
Bach eaae had 1 or aoce of the
following: polvvlacecal congestion.
cecebcal lajacy, eacephallc and
pglaonary adaaa. bcoachlal pntaaoala.
hepatic cltchosla.
IDDLISj CBXIDIBBi aOTOfSXBS;
• IftCOITOlalBTSi BUBOnCSt
iBTIDBPBISSin MBBtas BIOOD PtlSBl;
BBIXB; LOISSI KlOinSl LXflBl OBXIBi
DIDOS; DIOO llBlaPtj RRaBOlRIS:
soicioii DIOS iBosit ITU.TI USB
Bxnoiiis
a) 2 «X after first dose
t| S days after first dose
c) 27 dava after first dose
20 agAg dose follomd by dally
aalnteaaace of S ag/kg/day.
leonataa (30-«0 vk) vlth selnres.
Bagea loaen'a Hospital la plttabnrgh.
PI.
EIOOS; BLOOD PLISHI; BBIBON; DBOO
IIBIIPTt PBIISTLVIIXI
IB
loblasoa.
•cDowall,
197g
Sllghtoa,
1978
rerraza.
Tedeschi,
Barlgo, I
Castagna,
197g
Pltllck,
Pa la tar,
Plppengar
1978
niBBCI
I.B.
B.D.
B.L.
S.D.
L.
.
P.
I.
B.
, c.
Ui
-------
Cerbitaric add, S-ethyl-S-pbenrl- (8 CI)
:.4,6(1B.3H.5R)-Prrinidlnetrlone, 5-ethrl*5-phenrl-
50-06-6
C12-B12-I2-03
i» 212.23. ni i->u-na c
(COITIIOBDI
TISS08
1720
Blood.
plant
1721
Blood.
plaiaa
1722
Blood,
••ran
_
1723
Blood,
aeron
172*
Blood.
mcaa
EIPOSTO! ROOT!
Ingest ion
Ingest ion
Ing* st ion
Ingest Ion
Injection
Injection
UALRICIL
BETHOD
GC
RIl
EC
Bit
GC
BDBBSB
or ctsss
8.0-74.0 09/1!
lot applicable
a) 8-0.12 og/nl
b) 70-15 og/nl
a) 0.72-0.035 aeo/el
b) 0.61-0.02 aeq/el
a) 3.4-12.7 og/al
b) 19.3-50.4
25.9 ng/*l
16 aj/1
al lot gi»en
b) lot given
a) lot applicable
b) lot applicable
a) 7.1 og/nl
b) 30.7 09/11
IIFOBUTIOI
< patient* given Prlnidone
(2-deso
-------
Barbiteric add, 5-ethyl-S-pbenyl- <• CI)
2,«,6(1B.3R.SB)-Pyrlnialnatrloae, 5-ethyl-S-phe»yl- (9
50-06-6
C12-B12-12-03
II 232.23. II 17«-1T8 C
(COITIIOID)
nssoi
1725
BlOOd.
•hole
1726
Brain
1727
Brain
1728
cerebrosp
fluid
B IPO SUM IOOTI
Ing**tlon
lng**tlon
Ingest ion
Ingest Ion
hlUTHClL
BJTBOD
ec
oc
Innanoenxysatlc
OC
IOBBBI
OF CaSBS
1
•1 1
b) 1
c) 1
dl 1
*> 1
8
a
UMB
lot applicable
a) lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
e) lot applicable
3.9-26.0 ag/g
2.3-»9.0 ag/al
(ISXT
n»
a.o sg/1
a) 20.9 ag/g
b) »5.» og/g
c) 6.2 ag/g
d) 27. a ag/g
el 26.1 ag/g
11.2 ag/9
13. 1 »g/nl
PtSE)
oiiEitL xnoiianoi
Onforealnted iliture of barb iterate*
Ingested
Specimens collected at aatopay.
Froa a groep of 30 coroner's cases.
17-85 yr old. where administration of
barbituatea ea* suspected.
D108S; DI06 180 SB; SBBaTITIS]
IRaBOLITBSt aeTaBOUSB: lOTOPSXBSt
fCIBISIC BIDICIII; MOOD! BXIB:
iniBTSi loiast spun; ORXII; OIITBD
IIBODOH
a) 71 yr old nan, mlcld*
b) 27 yr old voaaa
c| 5 yr old girl, epileptic.
agbtherapentlc levels of
dlpheaylhydantoin also found
d) 5* yr old nan. posttraanatlc
epilepsy, previous suicide attempt
•) 5* yr old nan, depressive
iyndroee, blood alcohol level 2.98
9/1
111 died of *cote Intoilcatlcn (cos
conblnatlon of phenobarbital and
flaraxepa*.
Deep cona. cardloclrcnlatory
collapse, shock, coaplete artflula.
Bach case had 1 or nore of the
following: poly visceral congestion,
cerebral Injury, encephalic and
pilnonacy edena, bronchial pgeanonla,
hepatic cirrbo*!*.
ItOlTS; CBILOiei; 10TOPSXBSJ
iniCOITOLSllTSl BIHOTICS;
IITIDBPIISSXfB aGBRS; BIOOD PLaSBa:
eiui; loiast Kioinsj LITII; ami)
DIDGS; DIOC TBBIIPT] BITaBOLXTBS;
SOXCIDBi BBDS IBOSJ; ITllI; CtSB
aiSTOIIBS
6 patients given Prlsidone
(2-desozyphenobacbital) at doses of
SOC-7SO ng/day, other 2 givec
phenobarbital, 90 and 300 eg/day.
Ipilepsy patients. 13-38 yr eld.
IITICOfTOlSIITSt BLOOD; BLOOC PUSHat
DltBBiyLIIDklrOXIS; DI06 TIBUPT;
Cltlli SPIIal riOID
,
6 patients given Prinldone
|2-desoiyphenobarbltal) at dcses of
500-750 sg/day, other 2 given
pkenobarbital, 90 and 300 ng/day.
tcilepay patients, 13-38 yr eld.
(ITICOITOISIRS; BIOOD; BLOOC PUSBl;
DlPBBITiByDIITOXISl DIOG TBBI&PT;
Hill; SPIIIL fLOID
1ZFBIBICI
loblnsoa. a.t.
BcDovall, l.D.
1979
Ferrara, s. D.
Tedeschl, L.
Barlgo, B.
Castagna, P.
1979
Vajda, r.
•illiais, F.R.
Davidson, s.
Palconer, B.I.
Breckenrldge, I.
1971
fajda, t.
•llliass, F.B.
Davidson, s.
Palconer. B.I.
Breckenridge, I.
1971
-------
Or bit uric acid, 5-athjl-5-pbenyl- (a CI)
*.»,«( 13, 3R.5HI-PTtleldtnetriODe, 5-ethrl-5-phenrl- (9 CI)
50-06-6
C12-B12-I2-03
Bl 232.23. IP 17H-178 C
(COIIIIOfOI
TISSUE
1729
Kidney
1730
(Idaer
SIPOSOBS BOOTH
iBgaatloa
iBoxstloa
tniTTICUL
RETROD
OC
Iiannoeniraatlc
OC
RORBEB
Of CtSES
•1 1
b) 1
cl 1
41 1
•) 1
1
BUGS
i) lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
•I lot applicable
lot applicable
mi
a) 32.2 ag/9
b) 61.3 09/9
c) 20 . a 09/0
d| «2.3 09/9
e) 1«. 2 og/g
3.5 eg/kg
CEItlll IIFOBIUTIOI
a) 71 yr alt tan, aelclde
b) 1~> fc old ooian
c) S jc old girl, epileptic.
gabtaecapeatic le>el> of
dlphcnrlbfdaBtoin also found
d| S* fc old aan, poittcaaiatlc
a(llep«r> pre»loa» aalcide atteapt
e) S* Jt old
-------
aacbitiric acid, S-otkyl-S-phanyl- (a d)
2.*,6(1l.3R.5B)-fyrisiaiB«trlon«. 5-«thyl-5-pk«nyl- (9 CI)
C12-B12-B2-03
II 232.21. I* 17a-l7« C
ICORTXROID)
TTSSOB
1731
liT«
1732
lt»«
1TJ3
Lung
173*
SplMD
___——
BZPOSOIB ROOT*
Ing*stioa
Ingostion
lagostlon
Insertion
1 —
1HLTTICH.
RETROD
SC
XiMnorairsatic
.-
OC
oc
oc
IORBI1
OP CISBS
•1 1
bl 1
c» 1
d) 1
•> 1
1
1
1
RIBSE
«) Rot applicable
b) Rot applicable
c) Rot applicable
d| Rot applicable
•) Rot applicable
Rot applicable
Rot applicable
_
Rot applicable
(•fir
IBIB
*) 60.3 »9/s
b) at .2 og/g
c| 2S.8 19/9
4) S6.S og/g
•) 2«.S og/g
a. o «gAg
2.0 19/119
7.0 «g/kg
?tcci
SIIRR1L IRPOIMTXOR
•I 71 yr old nn. loicld*
b) 27 yc old •oiu
c) 5 yc old girl. «pll«pttc,
«lbtk«r*p*ltlc !•*•!• of
dlpk«nylliydMtalD «l>o foud
d| 5» yr old no, pocttcmaHtlc
•pllcpiy. pc*«iou nleld* «tt«ipt
•1 54 yr old •»> tepruslT*
•yidcon. blood (lookol !•*•! 2.98
g/i
111 dl«d of «ait« iatoxlcatlai (roi
coibiutloi of pk«iob*rbit*l *•«
tlmrapii.
Dmp co««, cacdloclrcaUtocy
colUpsv, okock, eoipl«t« uiflult.
Rick c*s* kid 1 oc iot« of tto
follovlagi paly*i>c«ril conaistloi,
ctnbnl lijicy. •icopkilic and
Uln»cy «dlxt«c« of bacbitarat**
l>9Ht«d
SpodMM eoll«ct«d at tatopiy.
(coi t gcotp of 30 coronic'i OMI,
17-as yc old. «h«c« adilalatntloa of
bicbitocitoi *•• •••poctod.
OROOSi OBOO IBOSIt SBOaTITSSi
IITaBOlITBS: BBTIBOlISBi lOTCPSIBSl
rORBRSIC BBDICIRB; BtOOD: BUB;
RIDRBTSt LOROSl SPLBBB; ORIBI; ORZTBD
KIIODOH
Oifocaalatod ilxtac* of bacbitocat*«
log*it«d
Sp«clit aatopiy.
tiom a gcoip of 30 coconoc'i can*,
17-BS yr old, »k«c« administration of
barbitacatoa «•« >up«ct«i).
DIOOSJ 0100 kBOSt; SBDITITBS;
ItTtBOUTBS; HST4BOIISB; lOTCPStRS;
FOIFISIC BBDICIRB; B1000; tilt;
IIDRBTS; LOR65; SPLBBRi OIIUj UIITBD
(tiioooa
BBTIURCB
rcrraca, s.D.
TodMcki, 1.
Bar 190. B.
Caattana. P.
1979
Robinson, a.B.
BcDo>all, B.D.
1979
loblnson, a.B.
BcDOiall. B.D.
1979
Robinson, t.E.
BcOo»«ll, R.D.
1979
Ul
VO
-------
iarbitnrlc acid. 5-etkrl~S-phonrl- (8 CIl
2.4.6(11,3a.5K)-Prrlnidinetrione, S-ethfl-5-phenrl- (<> CI)
50-06-6
C12-812-I2-03
HI 232.23, *f 17»-178 C
(COntlOED)
TISSUE
1135
Vein*
1736
Orin*
1737
Urine
EIPOSOBE ROOTI
Ing* at Ion
-
Ingentlon
Ingection
lltLTTIctL
BBTBOD
ac
ac
Innunoenzynatic
ac
ROBBBI
OP C1SBS
3
a) 1
b) 1
C| 1
d) 1
1
HklCE
.
a) (.0-5.3 ng
b) 19.2-3*. S ag
a| lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
lot applicable
IBll
a) a. 7 ag
b) 2«.8 ng
»6.« ag/nl
b| 3.8 ng/nl
c) «. 2
-------
Bacbltvlc add. 5-aec-batyl-5-etkyl-, aodlaa aalt (8 CI)
].l.6(1B.3B.SR)-Pyrlai4lBOtrl0Be, S-etkyl-S-(1-aetfcylprop»l)-, aoaoaodloa aalt (9 CI)
1*3-81-7
C10-B16-12-03. la
IB 235.27
TISSUE
1738
1739
Blood,
wkolo
17*0
Kidney
EXVOSni BOOT!
Xaoaatloa
lageatloB
lageatloa
alllTTICIL
BBTBOD
OC
sc
OC
IOBBB1
OF CiSBS
a) 3
b) 1
a) 3
b) 1
a) 3
bl 1
UNI
a) 27-131 ag/1
b) lot applicable
a) 18-19 ag/1
b) lot applicable
a) 23.5-71 agAg
b) Bot applicable
(•BIT
an
a) 69 ag/1
b) 21 ag/1
a) 29.7 ag/1
b) 23.0 ag/1
a) a 1.7 ag/kg
b) ae.S ag/kg
PtGE)
SIIBIaL IIFOIIaTXOI
a) slagle barblteric add derivative
b) OBfocaalated alxtares of
Scaclaeaa collected at aatopay
lydroxylated aatabolltea aaa ally
present la lower aaoenta thac parent
drag la flalda aad tlsaaea, aad ta
ktgaac aaoaata tkaa parent drag la
urine
Itkaaol la aoae blood apeclaena.
Proa a groap of 30 coroner* a casaa.
17-85 ft old. share adalalatratloa of
barbltaratea aaa aaapected.
DI08S; 0100 IBOSI; SEDATIVES;
BRIBOLITBS: BiTaBOLisa: incrsnss
Toinsic iBDXcxn; noooi BILE;
HDiiTS: Loies; spLiEii oiiu; oixtn
IXIQDOI
a| Slagle barbltaclc acid deilntiTe
b) oaforaalated al it area of
barbltaratea lageated
Bpeclaeaa collected at aatopay
l*drax*lated aetabolltea aaaally
praaant la lower aaoaata thai parent
drag IB flolds aad tlaaaea, aad IB
kigkar aaoaata taan parent deaf IB
arlae
Itkaaol la aoae blood •peclaeaa.
ftoa a groap of 30 coroner1 a caaea.
17-85 yr old, ahere adalalatratloa of
barbltaratea aaa aaapected.
DIMS; D10C MOSS; SBDtTXnS;
ItTIBOUTESl 8ET1BOLISI: 10TCJSIBS;
P01E1SIC BIDXCIlIt BLOODJ BXLBi
IIDIITS) LOISSt SPIEE1: OlIIlj 01IIBD
IIIODOB
at SUgla bacbltaric acid derlratlwe
lageated
b) OaCoraalatad alxtarea of
fcarbltaratea lageated
Speclaaaa collected at aatopav
lydroxylated aetabolltea aaa ally
present IB loaer aaoaata tbaa parent
drag IB flalda aad tlaaaea, end la
klgker aaoaata tkan parent drag la
arlae
Btkanol la aoae blood •peclaeaa.
Iroa a groap of 30 coroner' a caaaa.
17-85 yr old, wkere adalalatratloa of
barbltaratea aaa aaapected.
DBOOS: D10G aBDSE; SIDlTITBSi
BETIBOLITES; IBTtBOlISB: iOTCFSIES;
FOIIISIC BEDICIIE; BLOOD] Bill;
IIDBBTSI LOBSS; SPLEEI; OBI1I; DIITED
IIIODOB
nriiEicE
loblaaoB. I.E.
•cDaaall, 1.0.
1979
•oblaaoa, I.E.
BcDowall. l.o.
1979
Boblaaoa, a.B.
BcOowall, l.D.
19^9
-------
Barbituric acid. 5-aec-batrl-5-etbTl-, aodlea ult (t CD
2.«,6(1R.3H,5l)-Prrlaldlnetcioae. f-ethvl-5- <1-aetkTlpcopyl)-, eonoaodlna Ml
C10-R16-l2-a3.ua
HI 235.21
(9 CI)
(COITIIOED)
TXSSOE
17*1
Liter
17«2
lung
1713
Spleen
BIPOSOBC BOOTl
Xngeetlon
Tageatlon
Ingeatloa
klkLTTICU.
HETIOO
OC
OC
OC
IOBBSB
OF CISC
•1 3
b> 1
•1 3
b| 1
a) 3
b) 1
ItlOE
•) 17-63 ag/kg
b) Hot applicable
a) 21-51 eg/kg
b) lot applicable
a) 23-68 agAg
b) lot applicable
(HIT
Hill
a) 62.7 19 /kg
b) $7.0 agAg
a) 32.6 agAg
b| 38.5 agAg
a) 10.3 agAg
b) 137 agAg
P1GI)
CEIEUl IIFOI81TIOI
• 1 single bacbitarlc add derivative
lageated
b) Oeforaalated eiltarea of
bacbltacatea ingeated
Speeiaea* collected at aatopfy
gydcoiflated aetabolitea aaaally
pieaent in loner anoaata than parent
drag In flnida and tlaaoea, and in
•ighec aaoant* than pacent drag in
acine
Etkaaol In aoee blood epeclaens.
Tcoa a gcoap of 30 coroner •» caaea.
17-6S jc old. ekere adalniatntion of
bacbltacatea •«» aaapected.
DIOBS; DI06 IBOSB; SEOlTIfZS;
BtTIBOLITES; RTaBOLISB: tOTCPSICSl
rOIEISIC SBCIC1IB; BLOOD: Bill)
IIDIBTS; 10103: SPIEIIi DIXIE; DIITtD
IIIBDOB
a) Single bacbitacic acid decitatl*a
lageated
b) Onforaolated alitoce* of
tatbltecatea iageated
Speclaeaa collected at antopay
BydcoxTtated •etabolite* aeaallf
pceaeat In Icnec aeoonta tkaa pacent
dcag in field* aad tiaaaea, aad in
kigkec aaoaat* tkaa pecent drag in
mine
Itaaaol la acae blood apeciaena.
Icoa a gcoap of 30 cocoaec'a caeea.
17-8S fr eld, ekece adaialatcatioa of
bacbltetatea eaa aaapected.
DIOGS; DIOG UOSEj SEOanTB5|
BIT1BOLITBS; RITIBOLISB; tOTCTSIBS;
FOBBI3IC BEDICXIIt BIOOD; Bill:
HDIETS; loiss: SPUE*: aunt OIXTIO
IIIODOI
a) Single bacbitacic acid derivative
lageated
b) Oatacaalated alitacea of
backitacatea iageated
Speciaena collected at aatopar
•ldco«7lated aetabolitea aaaillT
pcaeeat in lover aaoaate tkaa parent
dcag ia field* aad tiaaaea, tad la
kigkec aaoaatai tkaa parent dcag la
aclaa
Itkaaol ia aeae Mood apecieena.
Tcoa a gcoaa of 30 cocoaec'a caaea.
17-85 yc old, ekece adBiaiatcatioa of
bacbitacatea eaa aaapected.
BIBBS; DIM IBOS1; SDlTITISl
lITtBOtlTU) IfTIBOUSB; iOTOPSIBS:
POEBISXC HBICIIII BMODl BIIB;
iioiBTSt LOISS: spun i oixiit OIITW
III8DOB
BEFBUICE
lobinaon, I.I.
RcDonll, B.O.
ig79
lobinaon, I.E.
BcDovall, I.D.
1979
lobinaon, I.E.
BcOoiall. B.O.
1979
ON
-------
Barbituric add. J-MC-B*t7l-S-«*hrl-. •odlmi nit (8 CI)
2,«,6(1B,3I.:B)-ryrl*iaiii«trloM. 5-«thyl-5-(1-m«t«rlpropylJ-,
1*3-81-7
C10-I16-B2-03.B*
II 23S.27
•ono«odt«« Mlt (9
"tISSDB
17*«
drla«
BIIOSOBB BOOtB
Xag*atlon
1BURXCI1
BBTBOD
OC
BOBBBB
or CUB
3
UKB
4-38 ng/1
BB1B
22.7 ag/1
OBBIUl IBTOBB1TIOB
Slagla bvbltvrlc add d«clTitl<*
Sptclaaa* collected at aatopiy
Bydcoxflatad MtabolltM •••ally
ptaaaat la lomr aaoaata thaa pac«at
dcag la f laid* aad tlu««a, aad 1»
blgtor aaoaat* tkaa parvat drag la
Bthaaol la oa« blood ap«cla«n.
Ftoi a gcoap of 30 coroaax'a cu*>,
17-85 yr old. abac* adBlalatntloa of
barbltacataa ••« •acpactcd.
DBDSS; 01BB JBOSB; SB01TXTBS;
BRtBOlITBS) BBTIB01ISB; knCTSXBS;
rCBBBSIC BBDICIBB; BLOOD; BItB:
BIDBBTS) LOBSSl SPLBBB; DBIBlI 0«ITID
BXB0DOB
BZFBBBICB
Boblaaoa. ».B.
Bcoocall, B.O.
1979
-
U>
-------
Barbituric add, 5,5-diethyl- (8 ci)
2.«.6(1R.3B.5R)-PytiBldinetrlona, 5,S-diethyl- (9
C8-H12-B2-03
BB ta«.19, at tee-192 c
TISSUE
ms
Blood.
•hole
17«6
Kidney
17»7
li»er
_
n»a
ling
1T»9
Spleen
EXPOSOBB BOOTS
Tngestlon
Ingest ion
Ingestlon
Ingest ion
IngeStiOn
aEaLTTXCIL
NBTBOD
GC
GC
GC
GC
GC
•088KB
Of CaSBS
BiME
lot applicable
Bot applicable
Bot applicable
Bot applicable
Bot applicable
REAE
39.0 •«/!
31.0 a?/kg
ag/kg
35.5 ig/kg
3'.o eg/kg
SBBtBaL IBTOBR1TIOB
Onfornnlated alttare of barbiturate*
ingested
Speclaena collected at aatopiy.
Froi a groap of 30 coroner'* cases,
17-8S ic old, «aer« adalnl«tcatlon of
birblticatea »a aoipected.
DBOGS; DBOO HOSE; SBDaTITES;
KITIBOLITES; BBTkBCLISBi iOTCPSIBS:
FCBBBStC BECICIBE; BLOOD; BIIB;
IIDBBTS; IOBOS; SFLEBB: DBIII; OBITBO
KIBGDOB
Ontoraalateil alitare of barbiturates
infested
Scecliens collected at aatopay.
rcoa a gcoap of 30 coroner's cases,
17-85 it old, vhere adsin1stration of
barbltwates «a« aeipected.
DIOHS; DIDO IBOSB; SBDlNTBSi
BRtBOtlfBSl BETIBOLISBi aOTCPSIBSi
rOBBBSIC BBDXCIBB; BLOOD; BI1B;
(IDBETS: LOBSSt SPIBEB; OSIBI; OBITED
(IBODOI
OBfocaalated elzt«re of barbitentes
ingested
Speclaeos collected at aatopiy.
free a groap of 30 coroner's ci
17-85 yr old, ehon adalnistcattoa of
bacbitaratea «as easpected.
BBOOS; DBOO aBOJE; 3KDITTTBS;
BRtBOLXtES; BETIBOLISR; 1OTCPSXBS:
rOBBBSIC BBBICXBE; BIOOD; BIIB:
(IOBEIS; LOBOSj SKEBB; OBIBI; OBITBD
IIBGDOB
floforaalated alitare of bar bit orates
ingested
Sfecieene collected at aatopay.
fco* a groip of 30 coroner's cases,
17-85 yr old. «aere adainlstratlon of
barbltaratea ns snspected.
DIOOS; DBOO IBOSBl SED*KTES|
gRlBOLITBS; BBTlBOLtSB; 10TCP5IBS:
fOBEBSXC BEDKIBEt BlOOOj BIIB:
IIDBETS; LOI8S; SPLEEB; OBIBI; OBITBD
IIBODOB
Onforaalated siitare of barbitarates
ingested
Speclseu collected at aatopay.
Fros a gco«B of 30 coroner's cases,
17-85 yr old. »aere adainlstratlon of
barbltaratea «aa saspected.
OBOG5; 0100 IBOSE; SBDITITBSt
rCBEBSIC IEDICIBB; BLOOD; BIIB;
BIDBETS; LOBOSl SPISEB; OBIBI; OBITBD
(IBODOB
(BEIT P13B)
Bobinson, I.E.
BcDoiall, B.D.
1979
Bobinson, I.E.
BcDocall, B.D.
1979
Bobinson. I.E.
IcDoeall, B.D.
1979
ON
Eobinson, a.E.
BcDovall. E.D.
1979
Bobiason, I.E.
BcDovall, B.D.
1979
-------
BicbUttlc icU. S.S-41«thyl- (8 CI)
J,«,6|1R,3R,Sm-*TCliUia«trlOM, S.S-41«tkyl- (9 CII
57-«*-3
C8-H12rB2-03
If 1(4.19. Bi 188-192 C
(COKIBOID)
TX330B
i7so
Brim*
BIFOSOBB 100TB
Ing*«tloi
1MLTTXCU
HBTBOD
OC
IOBBBS
OF CtSBS
- _
1
BltOB
Bot appllcabl*
HAB
289 19/1
CBItllL IIFOBHTIOB
-
HiforMUttd mlitara of b«tbUant««
lD9««Ud
SptciMB* call«et«d «t «atop«T.
Fcoi • 9cmp at 30 carancc'c cu*«.
17-85 rr old. «k«r« adililatntloB of
b»bltictt«< •>« •••pcetvd.
DiDOSl DIDO IBDSBt SBDIHTBSt
BRIBOLITES; BBTiBCLISB: lOTCPSIBSi
raiBBStc BECICIIB; BIOOD; BIIBI
«IDIBISJ I0»03l SPUBB; OIIIE; DIITBO
KBODOI
BBTSBBBCB
BoblMOB, t.B.
BcOOKll. B.D.
1979
Ln
-------
lari.ua
7MO-39-3
Ba
»t» 137.3*. St 710 C (approx), BP 1600 C (approx). TP 10 •• Rg at 10«9 c
TISSUE
1751
Bale
1752
Rale
1753
Kldnar
IIPOSORE 8OOTE
klkLITICtl
BBTROD
Ik
ts
ts
IOHBI
or cis
11
al 179
bl 108
c) 102
41 109
e| 126
fl 90
91 71
h) 85
I) 77
Jl «9
HOHBEB
or cis is
11
al 179
bl 108
c) 102
41 109
o| 126
fl 90
91 '1
h) 85
I) 77
11 *9
BIIGB
lot detectable-O.B ppa
at lot given
b) lot given
c) lot given
4) lot given
•) lot given
Cl lot glfm
g) lot given
h) lot given
11 lot glT«B
J) lot gl*«n
al lot given
b| lot given
c) lot given
(IBR
BE HI
0.2 ppi
al 0.5* ag/g
b) 1.30 ag/g
c) O.B2 ag/g
4) 2. «1 ag/g
•) 0.61 ag/g
fl 0.63 ag/g
g) 1.26 ag/g
h) 1.11 ag/g
It 1.36 ag/g
« 2.3* ag/g
OeOBBtrlC BBBBB
al 0.96 pps (13%)
b) 1.21 pps (15*)
c| 10.6 ppi (7()
FIGII
GIltllL IirOIHtTIOl
Scalp hair
Donors from 2 tillages of lalka
Indians In the laasonas Territories
of Venezuela.
BIIB; VBIIZniLl; RSTU.S; TliCE
ElBBBITS; SODIOR; IIORIIVR; SILICOI;
CBLOBIIE; POTISSIOR: SCllDIOl;
1IHIIOS; flllDIOIl: CB10BIOB; COLD;
laKalBSI; IBOI; COBILT; IICIEL;
COPPEI; tllC; tISIIICt SBLEIIOR;
eiORIlE; BOIIDIOR; ST1ORIOR; SILTEB;
IRIROII; IODIIE; CBSIOR; BinOH)
HITR1IOH; CBUOfl; SaRUIOR; RBKOBT
a| Bale children
t| resale children
cl Rale adults
dl resale adults
•1 Long Island children
() Queens children
gl Bronx children
h) Long Island adults
I) Queens adults
j) Bronx adults
Correlations betveea hair Ba and
housedust. hair Ba and «ex.
Iddltlonal data.
Scalp hair, Caucasians In IT, ages <1
to greater than 51 yc.
RHUS; TItCI BLIRIRS; Bill OB I
BOIOI; CiOBIOB; CRIORIOH; COIPBI;
HOI; LEID; UTBIOB; RalCalBSB!
BIICOIT; IICIBL; SELIIIOR; SIlfES;
Til; T1HDIOB; IIIC; RUB; 1CB;
itOLTS; CRILDBII; SIX: COBFlllTITE
ITILOITTORS; DOST; SOILS; all
COLLOTIOI; OIBII tlllS; IBI TOIK
at to renal disease
t) acute renal failures
c| Chronic renal failures
Dry >t basis
Percent of saaples sltk detectable
levels Is Indicated la parentheses.
lutopsles at OCLI Bospltal.
TI1CI ElBBBITS; BITilS; iOTOISIESl
C1LIPOIIII; IIOIITSt LITII; SPtEEl!
CISIISES; BTIIITBISIOl: SODIIB;
POTISSIOB; CILCIOB; PROSPIOIOS;
BiOIBSIOB; CIDHIOR; UK; COPPBI;
HID; 1101; ItiaMISB; HOBIIOB:
siucoi; TiTinuB; COBU.T; IICICBL:
BOLTBDBIOI; Til; CRBOHXOB; SnORIOR;
BI1IOB; UTBIOB; SILTII; TtliOIOB;
BOIOI
IEFE1EICE
Perkons, i.e.
Telandla, J.I.
Dlenes, fl.
1977
creason, j. p.
RlBBers, T. a.
Basgaraer, J.I.
Plnkerton> C.
1975
iBdrapraslt, S.
alexaader, O.T.
OOBlck, R.C.
197*
-------
BatlM
7MO-39-3
Bl
Itl 137.3*. HP 710 C (appro*I. BP 1600 C (approx), TP 10 » Bg at 10»9 C
(COITIIOBD)
TISSUE
175*
li**r
1755
Lug
175C
SplMB
BXPOSOIB tOOII
iniYHClL
BBTBOD
«S
IS
IS
BOBBBB
OF C1SBS
28
UNI
•I lot gi*«a
b) lot giT«n
c) tot gives
lot d*t«ctabla-56S.O ag/g
dry »t
•1 lot gl?«
b) lot gi*«B
c) lot ai»«B
mi
•1 1.17 ppa (91)
b| 0.28 ppi <6«)
c) 10.8 ppi (11X)
lot gtfon
•1 2.38 ppi (13X)
b) 0.77 ppi (13*)
c) 7.52 ppi (16X)
ai inn. xiraiUTioi
•) la r«Bil !• indicated in p>r«Btk«»«.
UtopcUi «t ocil txnpital.
TIICI ElBBMTS; DHLS; 10IOFSISS;
caiiroiiii; UDiits; tirnt svini;
OXSUSBS; BTPE1TEISIOI; SOOIW;
totissioa; ciicznii PROSPIOIDSI
BIOIESIOR; ClOHOBl UK; COPPBI)
IUD; IIOI; BMOUZSB; ILOBXIOBi
suicoi; TiTiiioB: COBU.TI IICKIL:
BoiTBDBiaa: TII; CBIOBIOBI snoRioa:
BUIOB; IIIBIOBJ SILfll; TlllDIUB)
B010I
Section of 1«BO« tro» igbjvct* «ko
kal b««n bltiBiaoai coal liawi foe
93-50 jr.
BITlLSl TItCI BLEB UTS; llOBIIOBi
HIXORs BIimiDI; BOIOI; CBWBXOB:
COPPBI; OBIB1IIOB; 1MB: L»C;
BISIBSIOB; BlIOtlESI; IICKEL;
SILICOI; SIITE1; III; TIIllIDHi
VlllDIOBi IOBOS; COkli OIXTBD ST1TES;
COIITI; IXBMU.3
t) 10 CVBll Ol«*«l<
b) teat* [
-------
Benxaelde. p-anlno->-(2-(di<>thylaalno)ethyl)- (8
Beaxanide. • -aalno-»-(2-
-------
118-7»-1
C6-C16
It 28«.BO. n 231 C. tt 323-326 C. TP 1 •• 19 at 111.1 C
TissoB
1760
IdlpOM
1761
adipose
1762
Idlposs
1763
Blood
176«
Blood,
plaSia
BIMSni BODTB
IHLYTICll
BRBOO
CC
SC
.
8C-EC
OC
__
CC-BC
BOIBBB
OP CIS IS
168
3
266
191
al 66
b) «3
C| 11
BIIQB
0. 001-0. 520 «g/g
a) 0.08-0.15 ag/g vet «t
b) 0.01-0.05 sg/g net »t
c) 0.08-0.11 19/9 cet it
lot given
2.6-77.9 ppb
a) 0-23 ppb
b) 0-1.8 ppb
c) 14-233 ppb
(HEIT
BUB
0.062 19/9
a) 0.13 09/9 mt *t
b) 0.05 119/9 net lit
c) 0.09 «g/g «et «t
5.20 ag/kg. TalM li
aedlan.
lot given
al 2. « ppb
b) 0. 5 ppb
c) 78. 6 ppb
PtGR)
GBIBUL 1 1708811101
Canadians fcoa Butacn Canada (16) .
C«b«c (SO) , Ontario (57) , Cmtcal
Canada (22) and •••tarn Canada (27) .
1*72.
PISHCIDBS; CBtOIIIB OKU IIC
CCBPODIDS; DRj BIHDill;
FCLTCBLOHIlTIO BItBEITIS; DtBi ODD;
IOI1CBLOI; BUkCBLOBOCTCiOBBIIBB;
OMCBMBOall; BBPTICHLOB BPORDB;
ItlPOSI TISSUE; C1I1D1
•) saapl* 1
t) Saapl* 2
c) sanpl* 3
Bin* dlff«c«Dt «clt«ta t!•«
hlghar than faaalaa, thos* aatlng
local prodac* higaar than other*, lo
aga correlation
n) oncipooad controla, 11-51 yr old
c) lorkara In chlorinated solvent
clant
Other data available.
Ispoeare to chealcal *aatea
containing hecachlorobeniene In t&.
lo catanaona porphyrla
LC8 elevated In exposed groa[. Orlne
corcopocphyrln correlated «ith
htsachlorobeniene.
LCOISIAHl; tGI; SEI; OCCOPkTIOIIL
BIZtlDS; CBLOIIITIO BTDBOCliBOIS;
fOOD COIT18IIITIOI; DOST; SKIN
DISEASES; BLOOD PLISIU; COHPMiTITE
IftLOtTIOIS
BBFEIEICE
Baa, J.
Caapbell, D.s.
Boblnaon, B.I.
Davlea, O.J.I.
1977
B*», J.
Caapbell, D.S.
1976
Ssokolay, ».
Boaival, L.
Ohnak, J.
Badarlc, I.
1977
Blchtar, E.
Schaid, 1.
1976
Burns, J. B.
Blller, F.B.
1975
VO
-------
Benzene, hezachloco-
118-7 a-1
C6-C16
Bl 2B».«0. IIP 231 C. BP 323-326 C, ?? 1 •• Hq at 11».« c
(COITtlOBD)
TISSUE
1765
Bilk
1766
Bilk, fat
1767
Bilk.
dhole
BIPOSOB1 ROUTE
IIILTTICIL
SETBOD
GC/BS
GC-BC
GC-BC
IOHBEB
or cisss
a| 10
b) 25
c) 35
d| 10
e) 20
f| lot
given
33
22
IlIGS
a) lot glt«n
b) lot glTen
c) lot gi»«n
d) lot giT«n
e) lot given
f) 1-21 nq/g
Trace- 5. 13 pp»
0.012-0.03* ppa
a) 1 ng,
b) 1 ng,
c) 2 ng,
d) 1 ng,
a) • ng,
l\ 2 ng,
0.091 p|
0.025 f
GEUBll TiroRBlTIOl
»«ipl«« abon 1
•) Baatoco Canada
b) QIIVIMC
c| Ontario
d| Ontcal Canada
• ) Intern Canada
C) latlonal
»9/9
latlonal Sarny.
IIPHBITL COBFOOIDS; CtltOt; CBLORIIE
CIGHIC C08PCOIOS; ODS: DDT;
IIIIDSII; BHPTICBLOS SPOIIDI;
IIIlCRLOROBZiniE;
BIXlCBLOIOCICLOBIXMZ; HILK;
IOMCRLOR; OIICBlOIDklE; PESTICIDES:
POIICBLOIIHTID BIPIMTLS:
(CITCBLORIIITID TIIPBBITIS
1977-1978 Btody
Patlants at public haalth offices.
tlberta. 17-309 daya postpactni. 2«
noicn llred In Edionton.
BILK; PESTICIDES;
BKICBLOIOCIUOBIIIIE; ODD; DDE; DDT;
DISlDHf: BIPTlCBtCB BPOXIDE;
BmCRLOIOBIIXKIEs CII1D1;
fOlTCBlOIIIlTED BIPBEIILS;
CCBPaMTIfE miOHIOIS
sarny. f««t«rn taitralia, 1970-1971
22 n»e»lng ioth«r«. nt *<-66 kg.
lltlng ulthlo a 30 ai radlM of
teeth, teitera autcalla
BILK: PESTICIDES; lOSIHLli; DDT;
OCE; DIELDIII; RIHCRtOIOBBiniS
Hea, J.
Davles, D.J.
1979
Cotrie. R.I.
Kadle, 1.9.
Breltkreltz, I.E.
connlngkaa, G.B.
Brans, G.I.
1979
stacey, C.I.
Tkoeas. B.I.
1975
-------
BeaieBeacetaalde. B-C»-cklocopBeBTl)-«-t1-(1-B*tfcyl«tBrl|-«-pipecldlBTl|-
39729-31-6
C22-B27-C1-I2-0
•I 370.96
txssoi
1768
Hood.
plaaaa
17C9
Blood.
plan*
1770
Blood.
plant
•XIOSUH 1OOIB
lajectlon
Xngeatioa
Injection
Ingaition
1I1LITXC1L
IBTBOD
_
oc
GC-BC
OC-BC
IDHBBB
OF C1SBS
8
5
3
I1IOS
900-1230 toys!
•1 0.10-0. 16 ag/Bl
b) 0.05-0.36 ttg/al
c) 0.15-0.36 ag/al
4) 0.05-0.** ug/al
•1 0.12-1.* «g/»l
f) 0.74-1.2* ag/al
•) 0.691-1.07 ag/Bl
b) 0.759-1.12 ag/al
c) lot applicable
d) lot applicable
*) lot applicable
f) lot applicable
g| lot applicable
h) lot applicable
mi
1065 ng/al
a) 0.1* ag/Bl
b) 0.22 ag/al
c) 0.25 ng/al
d) 0.23 ng/al
e| 0.11 ag/al
f) 0.95 ag/al
a) O.SBO ag/al
b) 0.9*0 ag/al
c) 0.380 ag/al
d) 0.06 ag/al
•) 0.3 ag/al
() 0.2* ag/al
gl <0.02 ag/al
h) 0.3 ag/al
GBIIB1L inOBBlTIOl
10-ala level* In 2 patleata after 10
ala IT of 1.5 ag/kg. Oecliae «a»
biexponentlal.
fatienta aitk alcoholic cirrboala.
3*-75 jr of age.
01065; LITII OISBtSBSl CIBIBCSIS;
BtTlBOLISBl CEIHlltl BLOOD P11SB1;
ItOLTS; 1ITI1BBBTTBBIC lOBft!;
IITIPIIBTICS
a) Loccaiaid*. 200 ag/day (n-3)
t) LocealBlde. 300 ag/daf (n-5)
e) LoccalBite. «00 ag/day |a«1)
d) lot-lOEcalalde. 200 ag/daj (n-31
e) loc-lorcaialda. 300 ag/day (n«5)
() lot-lorcainide. *00 ag/day (n-1)
•aziaaa steady otate level*.
Patieata with arckythaiaa frca
cacdiac oc cardlovaacalar diaeaeaa.
bat BO cacdiac failace. ceaal,
hepatic, oc cerebral daaage.
Chronic therapy pcodaced aveatiag and
iBaoaaia in 2 of 5 patlenta. 2 ag/kg
IV oc 300 ag orally pcodaced BC«-tiae
intecnl effecta. IT (6 ag/aia|
gcadaally aappceaaed Teatcicolar
creaatnre contraction* relattd to
plaaaa level, loc-loccainid* alao
klgklr ettectire aatiacchythilc.
DIOOS: 0106 TRII1PY; IITIkBIRTaBIC
IOEITS; BLOOD PUSH; BBTtBOUTSS;
BIlBt OISI1SBS; COIFUtTITS
tTlLOlTIOIS; GKIB1IY: 1DOLTS
a| Lung afferent blood (n-2) 0-35 aln
aftec 2 ag/kg IT
t) Lung efferent blood (n-2) 0-35 Bin
aftec 2 ag/kg IT
c) Li Tec afferent blood (n-1) 0-35
•in aftec 2 ag/kg IT
d) line efferent blood (n-10) 0-35
•In aftec 2 eg/kg IT
e| Steady state, 31100 eg/day IT
(n-1)
f| steady at ate, 3X100 eg/da; orally
(B-1)
g| lorloccainide ateady «tat«, 3X100
eg/day IT (n»1|
h) locloccalnlde ateady statt, 3X100
•g/day ocally (n-1).
Patient* «itk (cchythalaa frca
cacdiac or cacdiovaacalar di*eaaea»
bat ao cacdiac failure, renal.
hepatic, or cerebral daaage. tgea
65-77 yr.
CBOOS; UTIIBBHTTHBIC lOEItS ; BLOOD
CLISat; aDOLTS; COIPaltTITB
ITaLOkTIOIS; GBRBtll; RBIBT CISBtSES;
C1EDIOTISCOLII OISB1SBS; BBTIBOIISB;
BIT1BOLITBS
IBrBMBCB
(lots. 0.
riKher, C.
Ballec-Seydllti, p.
Sckali, J.
Bailee, 1.1.
1979
.
Balaectx, T.
Kaapec, I.
leratlng, T.
Jort, B.
Bechtold. B.
Jahnchen, S.
1979
Jabnchen, B.
Bechtold, H.
Ia«per, f.
Recatlng. F.
Ja*t, B.
Baykaata, J.
Belnerti, T.
1979
-------
B«oi«n«bat«nolc acid, 2.>.S-trl«thoi7-qa*ia-o«o-
• 1826-<>2-0
C16-H22-06
HI 310.38
Tissue
mi
BXPOSOB! ROUTE
Ingaitlon
Mill. YTICH.
HET8OD
OC/dS
ID8BEH
or casts
2
8I.VGB
lot qlven
HE»«
R1.1*
CEiEBAi i iron mri on
* deration of original coipcnnd and
utabolitds ID 2« he a(t«c dcslng (1
•9/kq) «ith «9nliolar listac* of d
«ob 0- and d iab 5-
tli«thoirb«niorlpropLoitDt«.
2 •«!•» (62 and 60 kg) .
DD01S; BETIBOLITES; OtTIE
BEFEBEHCE
Kobayaahl. T.
Kaoal. T.
Tanayaia, S.
1978
ro
-------
BrauBMtBBBol, alpha-<2-aaiBO-1-«»tkjlothTl)-alpha-phaByl-. propanoat* (a*t«c). (S-(l»,s»|(-
«2576-OT-8
C20-B25-I-02
•I 311
txssoB
1TT2
Blood
1773
Blood
177*
BraiB
1775
Kid DOT
.
1776
L1»«C
1777
Line
BXfOSOBB BOOTS
IngoBtiOB
IngaatiOn
InoBBtloB
Ing* at Ion
1IILTTIC1L
BBIHOD
OC
OC
OC
GC
GC
GC
IOBBB1
or cists
1
•1 27
b) 2«
c) 25
d) 20
9
1
9
11 KB
lot applicable
a) 0.01-0. 95 19/41
b) 0.07-3.79 Bg/dl
c) 0.03-1.68 Bg/dl
d) 0.03-0.50 ag/dl
O.Oa-0.55 ig/100 g
b) 0.46-9. 8 ig/100 g
lot applicable
0.»6-17. 2 ag/100 g
1111
1.9 «g/al
•1 0.37 *g/dl
b) 0.52 Bg/dl
e) 0.«2 ag/dl
d) 0.38 Bg/41
lot glT*D
lot gl»«n
10 «g/g
lot glT«n
6BIM1L XirOtUTIOl
Iitsl onrdoM fcoi tcinrleTpcoilM.
d-broiph«nicuiM, d-lsocphodrlM,
;ioposrpk*B«, alcokol.
55 jt old »hit» t«ul«.
IICOHOLS] IIBCOTICS; D1DOS; HOOD;
DIXIE: BI1II; LCTBIl UTIDBPIBSSIfB
IGBR5; CCIIICTIC01; DBOO 1BOSB; C1SB
IISTOBIBS
•) lento •xpomc* to pcopozr[k«iw
b) Pcopo«Tph«n* tboM «•••
c) C««a« of dotth »lmo»o
d| loB-pcopoiypkoB* colatod o»thi
l«*«l> of pcopozrpboB* Mtibcllta.
litrltad daring 197«-1976.
DBOGS; OB 00 1BDSB; C1SI HISTCBIBS;
BIOOD: BtlXI; LITII; RIOIBTS;
BIBtHID
lotabollt* of propoxTPhmo. Soloctod
on hl«tocl« InvolTlag drag HM »nd
•ba>«.
OiaOS; DBOO IBOSB; CJSB HISTCBIBS;
B1000; BBIII; LXTB8; KIDIBTS;
• ItTLllO
Bttabollt* of pcopoirphcn*. s«l*ct«d
ca«* blatoclas InvolTlng drag DM and
abuM.
DB06S; 01 DG HOSE; C»SE BISTCSIBS;
BIOOD; Btlll; LXTIB; KIDIBTS;
BIBTLtIO
Fatal ovocdoi* fcoa tEaDylcyF^oBlnog
d-bcoBph«BlcaaiB«, d-laovplMdrlM,
(topoirphon*. alcohol
L«T*la of noipcopoiTpkm* «l«o
available.
'5 yr old vblto foaalo.
UCOBOLS; HBCOTICS; DROGS; HOOD;
OIIIB; BBIII; IITEB; IITIDBPIESSITE
•OBITS; COIIICTICOT; DBOO IBCSE; CISE
BISTOBIES
Ectabollt* of pcopoxTphcn*. Seloctod
ca<« hlstoclu InTolTlag dcag am and
abaa«.
CIOGS; DBOG IBOSB; C1SS BISTOBIBS:
BIOOD; BIIXI; LItEB; KIDIBTS;
BIBTLIID
IEFE1EICE
BBMlt, B.C.
Shukan. B.
Gro««, B.I.
1977
CaplBB, T.B.
Thoapion, B.C.
ri«hw, l.s.
1977
CaplBB. T.B.
Thoapaon, B.C.
Flakic, l.s.
1977
-
Caplan, T.B.
TkoBpBon, B.C.
Flahoc. B.S.
1977
B««»lt, B.C.
Shaakan, E.
Gross, B.H.
1977
Caplan, T.H.
ThoBpBOB, B.C.
Fisher, B.S.
1977
OJ
-------
tantolc acid. p-(dlpcopTlaalUaoTl)- (6 ctt
Bantolc acid. «-«<)lproprl»alno)«uirotiTl)- (' CI|
Cl3-gH-«-o«-s
HI 2BS.36, IIP 19»-1»« C
TISSUE
me
carabroap
Inal
fluid
EXPOSURE ROUTE
Inject Ion
IIILTTICIL
BBTBOO
_
Colotli«trj
ROflBEl
or CISBS
1
BUG!
lot glf«n
. -
BBH
21.0 ig/al
GEIEItL IIFOHBITIOI
3 hr »(t.c 5-hr IT infasion of 75
• 9A4- lo iocr«««« in hoioTillinle
•eld. b«t «»«cp incc«*>«s in
5-hr4rox7'ln4oi«K«tlc tcld, c»np,
and coup.
•ocker, agld 25 fr, oecapatlonallr
to 19.
BISHUTB; BEICOII; BETlLS; BEItL
Eoisoirio; aaiii; BLOOD; SPIHL
TIDIOi GEBSHT: lEDIOLOOIC
HllirSSTITIOIS
BEFEBEICE
Crai«ct R.
Banand, B.
Billiard, H.
8o>c«t, J.
Haaiara, B.
1978
-------
Bmsolc «da. p-uUo-. 2-(ai*tkrl*BiBO) «tkrl uter (8 CI|
Imoic acid. •-uUo-. 2-(4tetkrl**lno)«tkrl «»t«r (9 CZ)
C13-B20-12-0,
II 236.30. 1
tlMOl
Blood.
i
t 61 C
Biposon IOOIB
injection
lULRIClL
BRBOD
GC
•oi ni
or cists
26
UNI
3.6-11.0 ug/Bl
nil
6.6 «g/Bl
aiinii uroiBiTioi
_
l(t«c «. 8 Billion Hit* of pmnln*
(•ntellUa a.
?«ti«at« tc«»t«d for gonorrhea.
Toile c«*ctlon» la 0.89* oC • cllntc
popalvtloB. toipoBMii IxhiTloral
CIBBg««. BBdltOCT Ot TlHBl
4i«tacb»e«i, »w:«l>r tulteUag, or
••l»c«i. l**m taflalt* r«»ction»:
•••kBcss, diixlMii ui »yneep«.
Dines: siDitxns: BIOOD rusui
«IOnil; DIOG TBH1PT; IIIIIKJIICS:
IIFRTtOIi SEI
unuici
CCMB, 1.1.
L«ll>, 3.1.
Kraas, s.J.
mdccickion, X. L.
197«
Ln
-------
B.otolc acid, 2-((«-ttcHloOEO««thTl|-«-q«inollBTH««ino|-
36783-3*-3
C17-B11-P3-I2-02
If 323
TISSUE
1180
Blood
EXPOSURE BOOT!
'
UlLYTICtL
HETBOD
Coloria«try
TLC
. •
IDHBER
or OSES
1
BlIGE
0.10-1.57 u«/al
Sii*
lot 9i»«n
GEIERIL iiromtTioi
Biogi ol Ma» 0.2S-R hr alter «00-ig
floctaC'nlo. D*t«ct«d by 0.25 hr,
paak 0.5-2.5 hr, cl««r«<5 by e hr.
Bcalthy >al«<, iq»* 21-28 yr.
08003; DIOG TBEItPI; BLOOD; IDOLTS;
OIEOOI; attlBOLITES; II TITRC
lllLTSIS
REFERERCE
Lyno, R.K.
Boll, R.
Svanoon, B.I.
Silth, 1.
0«rb«r, 1.
-------
Bauoio acid. 2-kTdraiy-, 2-«rboijpk«njl *at»r
S52-9«-3
CM-BIO-OS
•I 258.23, It 230 C
TIJSOB
1781
Blood.
plan*
BXfosmi toon
lamatloa
[
I
klUmcu
BBTBOD
•QBBBB
or CISBS
10
•kWB
a) »ot giTM
b) 9.M-1S.98 ag/dl
.
mi
a| 0.2* »j/41
b) 11.92 as/41
BUI IIFOIBkTjOl "~
•I *k 1, placebo only
«i«ut:Ba 3- daM *-*' 3 »*"
OwllMl to 0.980 ig/dl 36 kt a(Uc
lact aoao.
SO koaltky aal**, ign 21.50 yt.
lo lncr*>«* la f«cal blood le».
DIMS: BIOS TBB1IPT: WOSIOIj »WWS;
HOOD riksik; coBpiBtnn
Bmoktiois; etsnoittBsTxikt SISTBB
BIFBUICt ' —
Cokaa, i.
1979
-------
Beaioie acid. »-aalno-2-chloto-
C7-H6-CI-I-02
HI 171. IS, 1C 213 C (decoip)
TISSUE
1782
Blood.
plasea
1^S3
Brine
BXPOSOtE IOOT?
Injection
tflLTTIClL
RETROD
OC
tic
QC
TIC
IOHBSB
or CISES
•
2
MIOS
•I 0.2-0. 71 ng/al
b) 2.2-2.6 «9/el
c) 3.S-«.3 «9/al
4) 0.6-2.2 «9/al
•) 0.6-0. 8 «9/il
•) 3.9-13.* 19
b) 3». 1-89.3 >g
mi
•
•1 Rot gli«n
b) Hot 9l»«n
c) lot gi»«o
4) lot glren
•) lot glren
i| lot gif«n
b) lot given
GtltllL IlfORIllTIOI
a) 2 "in
b) 10 (in
c) 30 iln
d) 10 lin
•) 60 iln
?!•«•• pco(ll«« dn[ii>9, «ft«i 30 ilr.
intulon of 250 19 chloroprocain. 2
pttlmts «itb 800 19 foe olwtctrie
• pldictls, pluu !•*•!> of
••ttbollt* ••» 0.03-0.09 0.9/11 in
aitliical tctccr. O.OT-0.«5 og/ll in
•ibiiieal »«ln, 1.97-2.78 ig/«l in
•it«rnal »«ln.
•••Itkr ••!•* and f»al««.
OIOI7S; RETtBOLITES; B10OD PtlSBl;
KtSOIEIBIT RRIOD5; OIIK; IZI TOilt;
oieniciL con
a) Fr«* coipooad (2.5-8.6% of don)
b| Conj«9at«l (21.9-S7.1t of do«*|
4aouit •Ker«t*d in 90 Bin after 30
•In Infaiioa of 250 19.
2 «oam la labor.
ClOeSi "BTIlOtlTES; BJ.OOD P1ISH1;
IliSOIBIEIT 8BT80DS; OIXIE; Ul TOBK;
OBBItlCiL COID
1
ttrttact
O'Brien, J.I.
ibber, T.
Hinsrack, 0.
Pecel, J.
riniter, B.
1979
o*Brien. J.E.
abbar, T.
Biunrk, 0.
Pecel, J.
rlmtec, a.
1979
00
-------
MnoplMBOM. •.••-dlehloto- (t CXI
MthuoM, bU(*-ckloropk«irU~ t* CI)
90-98-2
II JS1.13, BP 1«7-1«B C. BP 353 C «t 757 •• 19
nssni
178«
UIPOM
iMomi Mara
-
aiuiTicti
UTIOD
SC-IC
BOBBBI
or cists
,
3
UMB
. .. .
*) 0.39-0.63 mg/g «*t it
b) O.S«-1. 17 if/4 ««t itt
c| 0,«9-0.77 ng/g wt »t
IBM
-
» 0,52 a«/9 *«t it
b) 0.79 «9/9 adlpoM UMM eoU«et«a during
••tap«lw OD «ccl4«it TlctlK.
cnoixii oie>nc coaponos; UINSB
ttSSOB; COIMUTITI BTUOiTIOfS;
intopsiBs: nsTiciDis; DDT; 0muc
ICIOSl MlTCaolXBlTED BHIIRU
BBTBIBICB
Bm, 3.
CMplMll, D.S.
1976
-------
Recylllae
1MO-«1-T
Be
»t« 9.01218. BP 12B-> C. BP 2500 C, TP 1 •• Rg at 1520 c. 10 » Rg at I860 C
TISSUE
1785
Long
1166
lung
1787
lanq
1788
Lang
BIPOSOHB BOOTS
IMLTTICtL
RETROD
KS
BS
-
BS
ss
IOHBBB
OP CISES
30
20
129
13*
BIKE
lot detectable-7.6 ag/g
dry «t
lot given
0.1«-0.38 ag/g dry >t
0. 1«-0.38 «g/g dry it
BED
lot given
0.2 ig/100 g dry «t
0.22 ig/g dcy «t
0.22 *g/g dcy «t
GEIEUL IIPOIBITIOI
Sections o( lung* froi subjects vho
bad been bitoslnoas coal liners foe
23-50 yr.
amiS; TB1CE ELEBIWTS; ALOHIPOR;
BiBIOB; BERYILIOB: BOROI; CRBOHIOR;
CCPPBI; GERHtllOH; HOI; LEU:
BIOIESIDB; BilGUBSB; IICKEL;
SILICOl; SIIVBB: Til; TTTiBIOB;
VIIIDIOH; tOIGS; COIL; OIITEt ST1TES;
Q01BTX; RIIEB4LS
Iicladea appec and lover lobes, and
lyiph nodes of long. Additional data
available.
Sections of longs fcos sebjects «ao
had been bltailnoas coal slnecs foe
12-50 yc In Balelgb Coanty, lest
Virginia.
RETU.S: IB act ILEREITS; coat;
BHTtlHTB; CCBILT; CRIOUOB; COPPEI:
IBOI; LBID; BlGIBSXOH; BUOUBSB:
IICKBL; TIlkllOB; VlltDIDB; ttlC;
IDIQSi COBPIIITIVE BVllOlTIOtS;
SILICl; OOIITI; ITBPR IOOES; «BST
VIBQIII1
Sections of longs fcos deceased coal
sinecs fro* Balelgk County, n.
HBT1LS; IBICI ELEBEITS; COIL; SIUC1;
(IIILLIOa; CHBOHIDB; COPPBBt IBOIJ
HID; BioiEsioB: BUOUBSB; ncnt:
tlUIIOH; VII1DIOB: ZIIC; 1D*GS;
COIP1I1TIVE BV1101IIOI3; «ES1
VIBOIIIl
lange of aeans. additional data
available.
sections of langs fcos deceased lest
Virginia bltealnoai coal alners.
BBIILS; TB1CI ELBHHTS; COIL; SHICI;
BlinilOH; CBBOBWBj COPPEBl IBOIJ
UIO; BtOIESIOB; RllGilESI; IICIZL;
TITIIIOR; V»HOIOB; ITIC; 10MS!
CCRPtllTITE BVilOlTIOIS; IISI
VIKIlIk
BEPEBEICE
crable, J.v.
Xeenan, B.C.
•oloelcx, P.B.
Knott, R.I).
Bolts. J.L.
Gorskl, C.H.
1967
Keenan, B.C.
Crable, J.V.
Ssallnood, t.l.
caclberg, J.B.
1971
Sveet, D. V.
Ccoose, I.E.
Crable, J.T.
Caclbecg, J.B.
Lalnkact, l.s.
197*
Caclbecg, J.B.
Crable, J.T.
liatlac*. L.P.
Ionia, R.B.
Rolts, J.L.
Haoer, p.
lolovlcx, p.s.
1971
oo
o
-------
Blpaaiyl, ckloro (8 d)
l.l'-MpaaaTl, chloco dacln (9 CI}
1336-36-3
1IICI COBPOSITIOD OiraOtl 01 OIDBTB1BIIBD
TI3S0B
1789
Ulpow
1790
tdlpOM
1791
Idlpoaa
1792
Idipos*
— — — —
mosmi nm
aBunxcii.
BMBOD
OC
OC
OC-BC
OC-BC
OC
BOBBBB
or casts
166
3
•1 26
b) 68
at se
d| 39
•) 122
fl 99
91 151
h| 70
78
UNB
0.106-6.603 ng/g
«) 0.83-1.40 ag/g «at «t
b) 0.36-0.«6 ag/g rat »t
c) 0.51-0. 65 «g/g »»t «t
«) <0.5 ppi
b) <0.5 ff*
c) 0.6-9.9 ppi
d) <0.5 ft*
•I 0.6-9.9 ppi
f) 0.6-1.0 ft*
g) 0.6-1.* ppi
h) 0.8-9.9 ppi
1.0-49 ag/kg •ztcactabl*
Cat
(•KIT
HB1I
0.907 ag/g
>) 1.16 aj/g ««t vt
b) O.«1 ag/g mt »t
ct O.S* ag/g net «t
a) <0.5 pp«
b) 2« ir old and 2 atlllborna in
tanaark.
PISTICIDBS; DDT; DIBLDBIlS
IOITCU01IIUID UIBIITISi CaOBXIB
CIOIIIC COIPOOIDS; aDXPOSB TISSUE;
E1»II; LIT M; COBPAIaTITB
IVILDtTXOIS; IDOLTS; IBIBOII;
DtlfllBK; SBI
BBrBBBBCB
B*«, J.
caapball, o.s.
Bobluoi. B.B.
DlVlu, D.J.I.
1977
Baa, J.
caapball, D.S.
1976
-
Barns, J.E.
197«
Kraal. I.
karlog, 0.
1976
00
-------
Biphaayl, ehloro (8 Ct|
l.l'-BLpaenyl, ehloro darira (•> CD
1336-36-3
(ItCT CORPOSITIOE ORKIOVR OI ORDETERRIEED
(CORTIIOED)
TISSUE
1793
Idiposa
179*
adipoia
1795
Idlpoaa
tdlpon
EXPOSURE RODTB
Inhalation
Ingaation
(LR1LTTICI1
RETROD
GC
cc
GC/RS
GC
GC
GC
• OBI
or ci
73
a) 3
b) 2
a) 30
b) 30
c| 1*
dl 1*
a) 33
b» 17
ROHBEI
or casss
73
a) 3
b) 2
a) 30
b) 30
c| 1»
d| ia
a) 33
b» 17
RIROE
a) tot giran
b) lot glran
a) 1.2-1.* ppi
b) O.»0-1.0 ppi
a) 270-1360 ppb
b) 210-1350 ppb
c) 270-960 ppb
4) 1-380 ppb
a) Rot givan
b) lot given
(IEIT
1E»»
a) 1.97 ppi
b) 2.60 ppi
a) 1.3 ppa (>hol«
tlasaa)
b) 0.7 ppi («hol«
tiaaoa)
a) 780 ppb
b) 600 ppb
c) «70 ppb
41 150 ppb
a) 5.8 ppi
b) 3.6 ppa
PICE)
GEIERtl IirORBlTIOl
• ) ««t tiim«
b) Fat
cata availablo for ago and an
gioipa.
tntopilos of •nb]«et> < or • 82 yr.
fee* Foci and Jytaskfla, Fin land.
MSTXCIDES; DDT; DDE; POUCH tOSIHTBD
tIPREIILS; CRLOIIll ORG1RIC
COIPOORDS; CRIORIItlED BIDBOCIBBOIS;
IMPOSE TISSUE; BBIII; LITE8;
AOTOPSIES; COHP1RITITE ETiLOIIIOIS:
IOE; SEX; riRURO
a) Tnaho pitlvata
b) Controls
»otop»y i«t«cial Cm 3 Toahc
pationta. Control* «»r» 2 accidoat
fictiu.
(IPHElIt COIPOOIDS; CR108XRE O1GIIIC
CCBPOORDS; RICE; OHS8ED CROtS; FOOD
CCITAHIUTICR; DISUSES; tOTCPSIES:
ETOICC0901ITIOI; POltCHLOBH IT10
EIPHBRItS: IDIPOSE TISSUE; KIDIETS;
LORSS; SPLEEI; tlTER; JaPH
a) Hat«cnal-(at only
bl Hat«rnal-total tlaaa*
c) F«ta«-fat only
d) F«taa-tot«l tlaam
Rotaors at cao*aroan birth ie
Kkaoka. Japan public hospital Dae
1973-apr 197*. stillborn f«tai«<
attar > 7 10 gastatioa.
USTICIDBS; POLTCHlOBIRiTEO
RIPBERTLS; BIPBERTI COBPOOIDS:
CR10RIIE OR81IIC COBPOOIDS; IDIPOSE
IISSOB; IDRBRIL QUIDS; BlOOt! LIT SB;
RILKi IDOITS; IIFalTS; FEIOS; JIPII
a) Grmalandari, 20-75 yr old.
»apl«* takan daring «cat«
lapiratoii**, !•*•!• incr«aa«d «ith
aga
t) Dinaa, 1-75 re eld, sadden daath
fcy •oleil* or in aato ace Ida Bt*
Badian ralaaa, baaad on lipid trt
Rat lit >aloaa availabl*.
Greenland ncnlndaitclalizvd araa
Oannark India trlallxad.
IBIPOSE TISSOE; a8I; aOTOPSIES;
CBLORIRE 01G1IXC COBPOOIDS:
PESTICIDES; ODD; DM: DDE; DIEIDBII;
BtPTkCRLOR EfOXIDB; POLTCHLOIlIltBD
BIPBBItLS; COBPIRITITE ETaLOITIORS:
FOPOllTIOI MPOSORE; GRIBRtlRD;
DIRH1RK
REfERBUCE
Battala, a. L.
mala, J.
laoaaki. n.
Baatta. K.
irstlla, 1.0.
1976
Ragayaaa, J.
Raaoda, T.
Karatanna, R.
1977
Raanda, T.
Kagava, 1.
Knroki, B.
Karataana. a.
Toahlaora, T.
Taki, I.
KMada. R.
Taaaaaita. P.
Bayuki, B.
197B
Janavn, G.E.
Claaaan, J.
1979
00
-------
Blpa*Ml, ckloro (B a\
I.V-BlphaByl, eklocp dari»s (9 CI)
1336-36-3
met COIMSRIOI oixioii 01 OEDBTEBBIIED
(COITIIDED)
TI3SOB
1797
Uranal
gland
1798
Blood
1799
Blood
1800
Blood
1801
Blood
Exroson tons
Ing* at Ion
1I1LTTXC1L
BBTBOD
OC
OC
sc
OC
10BBBB
OF C1SKS
16
•1 1
bl 1
•) 17
b| 16
_,
>l 5
b| «97
7
SHOE
6-80 ppb
•) 2.5-«.0 ppb
b) 2.3-3.5 ppb
a) <0.2-12.8 ppb
b) 1.7-«.6 ppb
a) 80-200 ppb
b) lot ginn
0.002-0.020 ppi
(I BIT
ml
26 ppb
«| fot given
b) fot gi»en
•1 3.8 « or - 3.6 ppb
b) 2.8 » or - 0.8 ppb
a) 116 ppb
b) 1 ppb
0.007 ppi
PIGt)
GBIIUL XBTOBUTXOI
Stillborn tatasas aft*r > 7 10
gaatatloa
PtSTICXDES: POLTC8IOUUT1D
BXCBIRLS; BXPBBIT1 COIPOOIDS;
CBMIIIB OBOMTC COBPOOIDS; IDXPOSB
1X3SOB; tDBBBlt OL1IDS! BLOOC; LXTEB;
BUI: tDOLTSt IIFklTS; FBTOS; JiPM
a) Sang* Iroi b«for« to 3-S hr after
iagutlng 181 ag PCB In fish
b) Bang* froa bafota to 3-5 tx altac
lagMtlvg 128 ag PCB la fish
l«*ala back to pca-lBgaMioa valoaa
bj 23. 5 he. littla or BO iBcnaa* In
PCB lovals fcoa control a»l«.
26 and 27 ji old Japan*** *atlng
citla** and iaaatan y*llo«t«il flak.
POIICHIOBIBIIID BIPBBITISJ FCOD
CCBTtllliTXOI; BLOOD; iOOLTS;
tlSTICIOBS; FXSBBS: JIPU
a) CblldriB. 1 ao-6 jt old
b) Rothara of ckildrm
Chlldran1* blood l*t*l nclad «itk
laagtk of braaat- f **dlng.
Baaldanta of 0*aka, Japan. Bo t tars
•1th no oeeapatlonal axpoaart to PCB.
FOLYCnOBIIlTH) BIFBEBtlS; BIOOD;
CBILDBBi; FOODS! FESTICIDBS; J»P»»
1) Saaplca IB uhleh PCB oaa x
positively ld*ntlfl*d
b) til aaaplaa
Poataortaaa. Tlcglnla stat* Badlcal
liaalnaca Ottlca, 1972. iboit »SX
fioa nklt* aalaa, 30( froa black
alias, 15t (toa «hlt* faaalai. 10X
froa black faulas.
CBLOIIWB OldllTC COHPOOBDS; IDT; DOB;
DIBIDSIB; fIBOXBXas BLOOD;
PISTICIDBSi POtlCHIOlIHTED
BiPBBins; aiMcaiciocicioainiB;
BEPTICBLOB 1POXIOE; CBLOFXBtnD
B1DBOUBBOBS
a) Before aaala
b) tttar aaala
Iftac aaala
PBTRUIC ICIDSi BLOOD; FOODS; OBGIRIC
CBLOIXBB CO 8 POD IBS; JtPlI;
ECLTCBLOBIBITID BIPBEIILS
MFEBEICB
Raaada, T.
Kagana, I.
Kazoklt B.
Karataine, g.
toibiaota. T.
Takl. X.
taioda, B.
I«»«ahita, F.
laraakl, B.
1978
Kavabara. X.
Taknahljl, T.
Vataaaba. X.
Toaklda. S.
Koyaaa, X.
Kanlta, I.
1979a
Knirabara, X.
Taka*kljl. T.
(atanaba, I.
Toahlda. S.
Koyaaa, X.
Xunita. B.
1979b
Qtlfftth. r.D. , Jr.
Blanka, B.T.
1975
Toalta. I.
Eakaaaca. T.
Tagi, T.
1977
00
u>
-------
SlpbeaH* caloco (8 d)
l.l'-BlpkaaTU chloro Aeriva (» CX)
t33C-3«-3
ItaCT COTOOSXTXOB NIBOIB 01 B(acmBt*tC
YXSStt
1802
Blood
1W3
Blood
Blood.
plaaaa
IMS
Brala
ixrosvBB Born
•
tBaimcu.
UTROB
ac
ec
ec
ec
BVBBSB
Of ClStS
al 60
bl 60
cl 15
*J 2->
01 IS
a 21
2*
29
•n
BaBGI
a) O.e-5.7 ppb
bl 0.2-2.5 ppb
Cj 0»^~3»( PP&
4) 0.5-3.1 ppb
ot 0.9-3.9 ppb
fj fl-7-6.2 ppb
al 0.3-7.6 ppb
M 0.3-1. « ppb
Bot al*aa
O.a-a.g ag/ka; extractable
Cat
Cats
«UB
a) :.S ppb
bt 0.61 ppb
el 1.8 ppb
« 1-3 ppb
•1 2. « ppb
0 2.5 ppb
al 2.8 • or - 1.5 ppb
M 1.1 • or - •.« ppb
0.819J ppa
8.7« as/kg
attractable fat
PISH
CIltUL IlfOI'HIOl
al Batertal bloa4-rtkaoka. Japaa
bl Cord blooe-rikaoka. Japaa
c) totbara of 2-3 aa ol«
laf aats— Karaaa* Japaa
4| Botkon of 1-12 eo ol4
Xafaatj taraao. Japaa
al Xafaata, 2-3 ao, Karaao, Japaa
f) lafaata a-12 ao Karoao, Japaa
Botbara «itk aoraal or eaoaaraaa
oollTodoa froa takaoka, Japaa, a»d
hoalthf aetkcra aaa tkalr lataatz.
troact fo4 (2-3 ao) or partlj «oaao4
|a-iJ ao). froa Karaaa. Japat.
risrxcxBts: POIICBIOHMIBB
tlFOITLS; EtPBIITl COBKMB>£:
CB1QUBI OBCUXC COBPOITBS; UIKSI
ttSSIC; IBBtBU CUB9S; BLOOt: ITTU;
gut: ivnts: IB HITS: retBS: jwii
M 23 aabllloal corda fro* act bora
loas «ltforoaoa botvoaa aotaora aai
coroa «ao« «ieroaao4 oa fat tmai*.
Cloo4 at partarltloa. Tokyo
1973^icaa*T*1»T«l* **C**b"
*
MlICBUBTBtTa* UPBEItLS; JaPal:
MOW: CBtCBXBaTBt mlOCatBCBS:
Bnxtxcti COB*: COB* UKITB
tlalllTTOBS
taaoetleldaa aad pcc'a la allk of
aotbara 2«-29 roara tbaa 3»-J9.
altaoaoa tba feraor aa« lovor l«»«li
la plaaaa. O*ar*alfbt aoaoa kad
Icaor lo*ol« tbaa >aaaa of aeraal
••ijkt. BoclAaa* ccae»atrato4 la
ottracto4 Held* ot plaaaa act allk.
t era* 11 •oaoa 2-* oaya after aoraal
4«ll*ory.
KsnctBtSi etao* rusu: nu:
rorauTioi nnsati; xsun:
CalOBIBaTZB BTtBOCUBOBS; UEXBS;
MI: tmt Bti; abs; poMcnoimn*
CnVtmS; BXPTaCUOB STOTI*!;
BixacnxnocTcioBa in
Saaploa fro* Walt aalea ooaerallT
bad klokoat coacoatratloaa. Sos
dlffomoea algalflcaat at 9«( level
la aaveral caaoa.
Beatlaa aocropad.** of adalt aab)acta
> 2« Ji oM aa4 2 •Ullboraa la
aaaaark.
ttsricnis: BIT: BSkt*m:
ratiCBLoiiBaTD Binnns; co.on»t
OBeiBXC COIPOBIBS; aaXPOSI TXSSaX;
UatB; IT»I1; COmtkTIVB
ITaLlaTTOBS: UBUS: BnBOIB:
BEBUBT: SIX
irrimci
aaaada. I
Caaaaa. B
Eeroki. a
laratane a.
XoaeUera T.
takl. I.
taaaaa. B
Taaaaalta ?.
Ba7aaal9 B.
1978
Ikljaaa. I.
Oki, C.
rajltaal. I.
law*, a.
Oalaa, B.
tavaaa. T.
1975
rollskak. X.B.
Boa, B.
Caeoa. S.
•asaeraaaa. B.
loaoacb. c.
19T7
traal* 1.
(arlo*. c.
197€
00
-------
cfcloro (• cn
cklflr* torin f» CD
133*-3«-3
raacx OMMSRXM rnnon 01 mrm
(commit
rxssn
1BOS
Bn.l»
ISO*
U**r
1809
U»«r
I81B
BXMSVn BOVTB
1IU.TTXCU.
ntaoi
ac
oc
ec/is
ec
ac
ec
cc
CC/IS
ec
mm
or cists
2
T"»
73
al 3
M 2
UKI
k] lot jl»a*>
0.03-*. 13 pp* (rtol«
0.5^-y M^ca. *ctr*ctak4,«
CM
a) Bot gives
k) mot »!««•
a) ». 03-9. OS pp* («fccl»
tlsswl
b) 0.02-0. e« pp* («kca*
(IITT
« e. 12 pp*
1.0* pp* c*kel*
fat
al «. IS pp*
k| 2.60 pp*
«| 9.95 pp* (»»ol«
tlsn*t
b) «. os pp* («kol.
MS 3
eram XDOIUTIOI
fel Fat
••t*. *vail*bl* for •«• a*4 *«z
••top*!** era* nb)*ct* < or • S2 yr
fro* foci. Fi*l**4.
FISnCIBtS; BK; Ml; FOlTCIIDUltTBD
etmms; cuoini aetnc
cononas; cBUuntn* BTUocainis;
ICIFOSI tiss«: itui: urn;
»si: sn:*Fiiun
EtFBxm. conoims; cnoint oiunc
ccmvns; *ict: onsm CBovs: root
ccntminet: etsitscs: intrsns:
SlOtCCWJiUTIQi; FXHTCBLOmtm
imtnu: IBITOSB TISSB; u>ms;
LVB6S; SFLI1B; LITBKs JlVaf
k*4 ktfkvst ooacwtratloax. s«i
1* MMral ca**a.
Io*tin ••cropcia* of *d*lt nbjacts
> 2k rr »U nd 2 xtllUocu i»
BWMtk.
FISTTCXBKS; tttz >ZtmZI;
CBsu-ic coiFcnos; tHFoss tissn-.
ItaLllTtOBS; a»nT£; mBOM;
tnuK; sti
al «*t UUM
k) T»t tlx*n
Ota arallafcl* for •«• a»< sa
l*tapxi*< of «tfe)*cts < or » 82 yt,
tea* Fari *»* JT*««kyli. N»I*>a.
FISTtCTBIS: BBT; 9BI; rDLTCIIOIIUTD
CIFUITLS: CBOUII OICUIC
ccnotns: ciu>uiH9 ITMOCUBOIS;
tciFosi tiss*i: Mill; urn;
kVTOFSTCS; CC8FalaHfV IT&LBaTlOSS;
ICI; Sti; FlUin
•1 Tisko patiuta
t| coMcola
Bctcxial fro* **t*>Fsi*s.
!IFR>TL COlFOfieS; OnoBIBl OXUfIC
CCIFOfnS; BK3; OILSBD CIO IS; P9OI
ccmaiBiTiOB; MS uses; IITCJSIIS;
iioiccmiiTiai: pcitcBLOUiirn
HFMiTLS; tUTOSI TXSSIT; tDIITS;
IBBCS; SFlttl; '.ITU: JaFll
•attvla. s,L-
Iktel*. j.
laouki. a.
Butt*, K.
acstu*. a.m.
Basa4a. T.
ttratsu*. i.
Era*l. !.
Bui 09. C.
19^€
•attal*. B.L.
Iktela. J.
lM**ki. >.
Baatta. C.
arltila. i.B.
l«9«fkM, J.
Basvda. I.
f*ratx**a, B.
00
-------
Blphenyl, chloco (6 CI)
I.l'-Blphenyl. chloco derlvs (9 CI)
1336-36-3
IMCt COHPOSITIOB OBKROIB OB OEDETESRIRED
(COETIBOEO)
TISSDB
1811
liver
1812
Lung
1813
811k
181*
• ilk
1815
•Ilk
EXPOSURE BOOTS
kMLTTICU.
BEtlOD
oc
GC
OC
OC/BS
EORBEE
or CISES
16
1
29
•1 »0
b) 38
c) 19
d| 20
•I 19
•1 10
b| 25
0) 35
d) 10
•) 20
f) lot
given
BUGS
0.3-21 ppb
Bot given
Bot given
» Bot given
b) lot given
c) Bot given
d) Bot given
•1 Bot given
_ _ _
a) Bot given
b) Bot given
c) Bot given
d) lot given
a) Bot given
f) 1-68 ng/g
KH»
7.3 ppb
0.01 ppa
0.0«»2 ppa
•) 2.« ft*. fat basis
b) 2.* ppa. fat basis
c) 3.2 ppa. fat basis
d) 2.0 pps, fat basis
•1 1.6 pps, fat basis
a) 8 ng/g
b) 10 ng/g
cl 17 ng/g
d) 8 ng/g
•1 IS ng/g
f| 12 ng/g
GUtBII. IBFOBHITI01I
Stillborn fetnsaa after > 7 to
gestation
PISTICIDBS; FOITCRIOII»TED
CIPHEBnS; BWHEIIl C08POOBD£;
CDLOBIBI OBGIBIC COHPOOBDS; IDIPOSE
1ISSOE; IOBBUL CHIOS; BLOOC; LIVES:
BILK; iDotTS; mrniTS; rBtos; JXNB
latopsy satsiial (cos Tasho [atient.
EIPBBBTL COKOOBDS; CBIOBIBE OBG1BIC
ccBPomos; BICE; OILSEED CBOFS; rooo
ccmaiHTioi; DISHSIS; IVTCPSIES:
BIOkCCOTOliTIOB; POLTCRLOBIBITEO
tlPHBIILS: »DI?OSE TISSOE; KIDIETS:
LOBOS; SPLBBB; LITII; J»PH
Blgk*E psrc«ntag«s of ocganochloclns
l*s«ctlcld«s and PCB'a In silk of
sothacs 20-29 T«acs than 30-39,
altkoagh th« focssc had lomi Isvals
Is plasna. Ovacmlght «oa«n had
lc«« l«v«ls than HOMO of ncrsal
••ight. Bssldaas conosntratad In
• itcactsd llpUs of plassa and silk.
Iscaall HOMO 2-* days aft*c nocsal
d«ll*«cr.
PISTICtDIS; BLOOD PUS Hi; BIIK;
ECPOL4IIOB tZPOSOIt; ISB1BI;
CILOBIBITBD ITDBOCaBBOBS; LIHDS;
101; OUT; DCD; ODB; TOLTCBLOBIBtTED
CIPHBBnS; BEPTlCatOB BPOIIDI;
BtKCHLOBOCICWIItlBI
•) 1973
bl 197«
c) 1975
d) 19T6
al 1977
Istlaatsd fcos graph
Bothers In Osaka Prefecture
8IPBEBTL COBPOOIDS; CBLOBIBB OBGIBIC
COBFOOBDS; DOI; DDT; DISIDBIB:
BIItCILOBOCTCLOBHlBB; JiPIB ; BILK;
POIICBLOBIItTED BIPBEITLS
a) Eastern Canada
b) Qaabec
c) Ontario
d) Central Canada
a) testern Canada
f) Batioaal average, staples above 1
sg/g
Bsasared as Irocklor 1260
Bitlonal sarvej. 1975
BIPBBBTL COBPOOBDS; C1B1D1; CBLORIBE
OBOIBIC COBPOOBDS: DOE; DDT;
DXBLDBIB; BEPHCnOI EPOXIDl!
BlUCBLOBOBBBIBBBt
BHtCBLOIOCtCLOBniBE; Ht«:
BOBtCBLOl; OIICBLOIDIBB; PBSTI CISES;
P01ICBLOBII1TID BIPBBBTLS;
fCLICILOUBIIID TEBPBEBTLS
REFEBEBCE
Hasada, T
Kagava, B
Karokl. B
Knratsnne H.
Tosh i aura T.
TaU, I.
Kasada, n
Tasashlta T.
Rayashl, n.
1918
Bagavasa. J.
Hasada. T.
Karatsane. n.
19"
pollshak, l.i.
Bon, n.
vassersann, fl.
cacos, s.
Vassersann, 0.
Leaesch, C.
1977
Taknshljl. T.
Batanabe, I.
Ksiabara, K.
Toshlda, S.
Rorl. S.
psksshlsa, s.
Rssklsoto, T.
(oyasa. t.
Kanlta, B.
1979
•as, J.
Davlee, D.J.
1979
(BBX1 PiBB)
00
-------
BlpkMyl. ckloro (8 a)
1,1<-Blpk«nrl. ckloEO darlTS {9 CI)
1336-36-3
II1CC COBfOSRIOB 01(1011 01 OIDSTBIBII8D
(COKXBOBD)
TZ3SOI
1B16
Bilk
1817
iilk, fat
1B1B
Bilk, tat
1819
Bilk.
•hoi*
1620
SplMB
BXPOSOBB BootB
kBklTTXCU
BBTBOD
oc
OC-BC
OC
cc
OC/BS
OC
BOBBBB
or casss
52
33
52
2
I1I8B
30-870 ppb
lot d«t«ctabl«-0.751 pps
1-36 ppb
Bat applicable
8MB
350 ppb
0.005 ppi
13 ppb
0.02 ppa
6IIBB1L JITOaaiTIOI
B**i««
iETIBI; POITCBLOUBMBO BIPBHTIS;
II1BB P01LOIIOI; POPOlaTIOB nPOSOBB;
IIS POLLOTIOI; BB1IT8 BltilDS;
CIBCIBOOBB; BUR
Botkvci of 2-12 mo old Infants
Btaltky aotban fcon K«nn«, Japan
aad th«lc bout («4 Infant* (2-12 no
old).
(tSTICIDES; POLTC8IOUBMBD
BIFBEBTLS; BIPBBBft COBPOOBDS;
cnoiiiB oistnc COBPOOBDS; IDIPOSB
1I3SOE: IDBBBll 8L1IDS; BLOOD; UfBB;
BILK! tDOLTS; IBP1BTS; FBTOS; JtPkB
1971-1978 atody
Catlanta at public kaaltk oCllcaw,
llbncta. 17-309 daya poatpactaa. 2«
>oa«n lived In Bdnonton.
BILK; PBSTICIOBSi
BIXkCBMIOCtaOBHUB; ODD; COB; DDT;
CIILDBII; BBPlkCBtiOB BPOZIDB)
BIIaCBLOBOBBBIBBB; CaBtDk;
ECIICBLOBIIITtD BXPBBBTIS:
CCBPltlTIfl IftlOlTXOBS
Bctknca of 2-12 no old Infanta.
Bipnamd aa total allk.
BvaltkT aothara fcoa Kama*, Japan
and tk«lr brvaat f«d Infant* (2-12 no
old).
fISTICIDBS; POLICBIOIIHTBD
BIPIBITLS; BIPBBBTl COBPOOBDS:
CBLOBIBB OBSIBIC COBPOOBDS; WXPOSB
IISSOBl kDBBBaL OLkBDS; BLOOC; LITBRs
BILK; IDOLTS; IlfaBTS; FBTOS; JIPaB
>ltop«r natnclal tcon Taako (atlants.
BIP8BBTL COBPOOBDS t CBLOIIBB 08QUIC
CCBPOOIDS; BICB; OILSBBD CSOPS: FOOD
COITIBIBITIOB; DISBkSIS; kOTCPSISS;
IIOICCOBOLtTIOB; POIYC8LOBXB1TBD
BIPBBntS; ICIPOSB TISSOB; KIDBBTS;
1 (JIGS; SPLBBI; LUBB; JkPal
BBTBBBBCB
BOTl«, B.B.
Blgkland. J.8.
1979
Basada, T.
Kagaia, B.
Kncokl. B.
KvratawM, B.
Toahlaica, T.
Takl. I.
Kaaada, n.
Taaaahlta, F.
Bayaahi, B.
1978
Cartl*. l.t.
Kadis. T.I.
Brvltkraltx. l.B.
Cunnlngkai, c.B.
Brans. B. 1.
1979
Basada. T
ICaqana, B
Karokl. 8
Kacatsans B.
Toshlnara T.
Takl, I.
Knsada, B
Tanaskita F.
Barashl. B.
1978
•agayaaa, J.
Basada, T.
xacataans. H.
1977
00
-------
l, 2.3.3',»t«t-p«i>t«chloro- (8 CII
1,1'-Biph«nyl. 2.3.31,»,«1-p«tMhloro- (9 CI)
32598-1»-»
C12-BS-C15
111 31C
tISSOB
1421
Blood
MPOSBIB BOOTg
IULTTIC1L
nnBOD
oc
BQHBEB
OF CISES
•1 9
b) 7
BUGS
.
*) lot glv«
b) lot glT«m
HBII
«) <0.01 ppb
b) 0.05 ppb
GCICBtL IIFOBBaTIOl
a) Tusko patiCQtl
t) Controls
EatUnts clth Tisko an a aocial
p*c*x>ns Ccoi tk« kc*pltal of Kyoaha
Uci>»c«lty.
JIPII; BLOOD; BIO»CCOBOL»TIOI;
CBLOBtIB OIQMIC COBPOOIDS; tDIPOSB
1ISSOE; BIPBBIIt CCBPOOIDS; WOD
CCIT.BIHTIOI
ECP5BEBCI
KicoU, U.
flasada, T.
1977
00
00
-------
ElplMiyl. 2.3'.«.»'.S-p««t»cU.oro- (8 CX)
1,1«-Blp»«Tl, 2.3<,».«1.S-p«»t«ckXoro (9 CII
3150B-00-6
C12-BS-C1S
Bl 316
RS50B
1822
Blood
_
BXFOSOH lOOtl
.
IIILTTICIL
BBTBOO
OC
IOBBBI
OF CIStS
•1 9
b) 7
.
11ISE
•) lot given
b) lot given
BBll
a) 0.13 ppb
b) 0.22 ppb
BBIBUl XBtOBBlTIOl
•) rnsho patients
b| Controls
Eatlents eltk Ynaha and nocsal
(•caons tcoa tks hospital of Kyosha
JlPal; BLOOD: BXOlOCaBOUTXOl!
cgioniB oiginc COIMOIDS; IDIPOSB
TISSUE; BXPBBBTl COBPOOIOSi MOD
CCITlHIIlTXOI
BBVBBBICB
KlCOU. B.
Basada. T.
1977
oo
VO
-------
Blaaath
7MO-69-9
Bi
lt« 208.98, IP 271.S C. BP 1579 C
IISSOE
IR23
Blood
182*
Blood
182$
Blood,
•hoi*
1826
Orln«
EXPOSOBE BOOTS
In?* at lOB
tlllTTICU
ntTHOO
MS
1ST
-
KOI
OF C
•I 1
b| 1
c| 1
35
1
BORBgB
OF CIStS
B) 1
b| 1
c| 1
35
1
IMS!
a) Not applicable
b| lot applicable
c) lot applicable
a) 1-12 ag/1
b) a-33 ag/1
c) a-30 ag/1
lot applicable
MM
» 640 09/1
b) 900 ng/1
c) 92 ug/1
a) • ag/1
b) 10 ag/1
el 12 ag/1
90 sg/1
GEIEilL IirOIBtTIOl
a) dale, 15 days after cessation of 1
•o of Bl aabnitrate aedicaticn
t) Fasale. aged 39 yr
cl Secaa of 5*-yr-old feaale who
occasionally used Bl for intaatinal
diitreas
Bale, aged 29 yr, 2 foaalos, aged 39
and 5» ft. Ill had acate Bi
encophalopathy.
Craapi, hallucination* (Tlaaal,
auditory, aad taate) , irregular
•TClonic tuitche* in the liata,
diatacbed apeech, atalla, ioioaaia,
apace-tlae disorleatatlon.
tcregelac BBS with DO craap
ootantiala. and coaplete inacania on
the sleep-polygraph.
JISBOT8: HBICDIT; BITILS; RIU1
FQISOIIIGf OIIIB; BLOOD; SPIIIL
HOID; 5EBHIII; IIDI01O6IC
BHIFBSTillOIS
BaTie*
IITILS; TMCI B1IRBRS; BI3BOTH;
BICOD; 01III; SBIIBOLISB; BEIIBI
a) Ik 0
b) Bad of 3 ilk therapy
c) Bad of 6 ilk therapy
Bach aobject received 1120 a?
coapleied (I/day in Bicitropaptide.
Fatienta in doable-blind clinical
trial.
BtTlLS; Dines; DIOG THBBtPT; BISBOTH;
BLOOD; OlIIBi COIPIIITIVB
BftLOkTIOlS; SOOTH 1FIIC1
lanale. Sa yr old, «ho had
occaelonally aaed Bi for intestinal
dlitreaa.
Craapa, halladnationa (Tiaaal,
auditory, aad taste) , irregalar
aycloalc teltohes in the lists,
dlatarbed speech, ataxia, issosoia,
space*tise diaorieatatlon.
Itngelac BBS vith no craap
potentials, and coaplete inscanla on
tha sleep-polygraph.
BTSBOTI; BZICOIT; BRILS; 1BUL
POUOIIia; OBIIE; BLOOD; 3PIHL
FtOID; OBBBIII: IBOBOLOOIC
ItllFBSTtTIOIS
BZFE1EICB
Craner, B.
Benaod, B.
Billiard, B.
Bonrat, J.
Banners, B.
1978
serfontein, D. J.
Hekel, B.
1979
Serfontein. «.J.
Bekel, 1.
Bank, S.
Barbezat* G.
lOTls. B.
1979
eraser, B.
lenaad, B.
Billiard, a.
Boorat, J.
Baaaera, I.
1978
(IBIt PtOB)
VO
O
-------
Blnith
TMO-69-9
II
Itl 208.98. IP 271.5 C, Bt 1579 C
(COITI1DBD)
TXSSOB
1827
OClB*
1828
OdM
Biposon soon
IBlLKXCll
BBTBOD
»ST
BUBBBB
OF CISBS
«3
itiei
•) 10-23 «9/l
b) 20-9*0 «gA
e) 31-780 ig/1
Bill
«) 18 «g/l
b) 272 09/1
c) 2*3 «9/l
eillllL XBFOBB1TXOB
-
*) Ik 0
b| Bad of 3 «k therapy
e) Bad of 6 «k tk«npy
tick *ibj«ct c«c«l*«d 1120 ig
coipl«i*d Bl/day la Bldtrop«ptlte.
F«U«nt« in dMbl*-bllad clinical
trUl.
anus; DBOos; oioc TBBBIVT; BISBBTB;
B100D; OBXBB; COBP1B1TITB
t»llOHIOIS| SODIB IFBXC1
BKllS; TBICB BLBBBRS; BISBOIB;
HOOD; OIIII; IRtBOLISH; BBHBI
BBFBBBBCB
Baak.'s.*
Bubmt. 6.
BoTt«. B.
1979
S«rfont«in, (.J.
i«k«l, B.
1979
-
-------
M«oaycln
1105S-06-7
COIPOSITIOI oinoii OR OIDETEBHIIBO
TISSUE
1829
Blood,
pla«aa
EXPOS0BB BOUTE
Injection
allLTTICtL
RETROD
BI1
ID8BEB
OF CaSBS
15
SHOE
a) 135-0 aD/al
b) 2500-6 oD/al
HEal
a) lot given
b) lot gi»«n
GBIEBlt IIFOBRtTIOl
a) 12-1*1 he aftec atact of
continuous Infuelog of IS oc 30 unite
a day foe »-5 dare
b) Iieedlatelr "4 12 he aftcc 7-10
unite I.I. foe 10 eln.
Data fcoa graph of 1 ezaeple each
•ethod
othec data available.
Patiente vlth *arlcue neoolaiee.
IITIBIOTICS; BIOOO PtaSHl; 01005;
CI06 TREBIPT; II »IfO tlaLISISi
CCBPlllTIfE ETaLOaTIOIS;
CIEBOT1BBIPT: THIS
BEFBBEKCE
Kraier, f.G.
Feloean, S.
Broaghton,k.
Strong, J.E.
Rail. S.«.
Rolofe, P.I.
1978
NJ
-------
Boron
7MO-*2-8
Itl 10.81. BP 2200 C (approx). BP 2550 C, TP 1.56X10(1-5) MB «t 21*0 C. 1 •• Bg at 2660 C. 10 H 19 »t 3030 C
TISSUE
1830
Bale
1831
(idler
1832
liter
1433
Lung
Biposoii toon
~
allLRXCIt
I8TBOD
BS
BS
BS
BS
I0BBBI
or CUBS
a) 265
b) 197
23
MBOB
•} 0.030-22.0 ng/9
b) 0.037-25.0 09/9
•) lot given
b) lot glren
c) lot given
a) lot given
bl lot given
c) lot given
0.3-15.4 ig/g drf vt
(•BIT
Bill
•I 0.881 BJ/g
b) 0.981 «g/g
Baoaatric Beans
•I 0.9* pp. (13*)
b) 1.15 ppi (3«S)
c) 1. as ppa (33*|
a) 2.31 ppa (33*1
bl 3.03 ppi (55*1
c) 1. 83 ppi (59*)
lot given
P10B)
6BIBUL mOIBITIOl
•) ChlUcci
b| Wilt*
lldlttooil 4iU.
Scilp h*lt, CaicMlans In IT, ig«s <1
to gc*it«c thin 51 Jr.
BITUSl TlkCI BIHIRSl BtBXOB;
BOlOlt CIDBIDB; CRIOnOfli COtPBI;
IIOI; IBID; ITTBiai; BtKtlB3;
IIICOIT; IICKL; SUBIIOBs SHTBB:
HI; VtllDIOB; IIIC: B1I»; ICB;
ICflltS: CBILD1BI; SIX; COBP»UTCTB
IT1LOHIOI3; DOST) SOILS; til
(OtLOnOI; 0«B» tlltS I IBI TOIR
•1 lo nn«l dlMU*
b) lent* cenil tdlini
c) cbconlc c«n«l fallnc*a
Dry it b»lt
P
-------
teron
7««0-»2-8
B
It! 10.81, HP 2200 C (appror), BP 2550 C. It 1.S6X10(B-5) at* «t 21«0 C. 1 •• 89 at 2660 C. 10 •• 89 at 3030 C
(COITIIOBD)
TISSUE
183*
BIPOSD8E gOOTE
IIILTTICIL
RETHOO
IS
IOIBII
or cisis
HIBt
a) lot 9lT«n
b) lot gl»«n
c) lot gi»«n
m.i
a) 2.57 ppi (S2X|
b) 5.01 ppi (77*)
c) 2.79 ppa (63*1
Clltlit IIFOII1TIOI
a) lo rtnal
b| lc«t« r«o«l
c) chronic renal tallacw
Ocr «t bail*
Vicont of itiplci «ith 4«t«ctabl«
!€>•!« IB indicated In pacantkuM.
lotop*i*« at OCL1 Boipltal.
TUCB ILBIERS; BEI11S; aOTOESIBS;
CILtroilIt: IIDIEIS; tITZI; SPtKl;
CISMSBS; BIPEItEISIOl; SODIOB;
fOTlSSIOB; CIICXOR: P80SPHOSOS;
BiciEsiai; ciDBion: me; COEPBB;
HID; noi; UtOllUI; 1LOBIIDH;
SIIICOI; TIT1IIOB; COBIII; IICIBL:
BOLTBDBIOB; Til; CHICHlim: S1RORIOB;
B1BIOB; HIBI08; SItTEB; T1IIDIOB:
tCIOI
IE7EBEICE
Indcipcaiit, s.
• Uianaw, S.I.
Gonlck, B.C.
197»
VO
-------
BEOBlM
7126-95-6
Jti 79.90*. It -7.2S C. •» S9.»7 c, Tp 1 •• Bg »t -60 C. 10 H 89 at -30 C
TISSOB
1835
1836
Drift*
BIPOSOBB BODTB
1B1LRXCU.
BBTBOD
It
It
BDBBBB
OP CtSBS
11
...___
I) 1
b) 1
B1IBB
25.6-«6.0 ppi
•1 3.5-10.5 »g/2» kr
b) ». 39-5. 30 19/2* be
BBIB
31.9 ppi
•) 5.8 *9/2» bE
b) ». 8» ig/21 bE
OBBBB1L inPOBHTIOI
Scalp balr
Coooc* Ccoi 2 »ill«9«« of lalki
Igdiiu la th« l»xou« T*rritorl««
of T«n«»«l*.
BUR; TBiBSOBU: amis: TBICB
BIBRBBTS; SOMD1; 1LORII01: SILICOI:
CBLOIIIB; POTiSSIOl; SCHOIOB;
TlllllOg; T1B1DIOB; CHtOBIOB; OOIO;
I1BOKBBSB; IBOBt COBUTi BICIBt:
CC»BB; IXIC; 1BSBIIC: SBIEIIDB:
BBOUBB: BoeiDioi; STBOBTIOB; SHVBB;
IITIBOIT; IODXBB; CBSIOB; B1HOB;
niTstiOB; cBtioa: siaiiioB; IBKOIT
•) B»«lthy ill*, 6 ill pits owe 9 10
b) Iteilthy («Ml«, 2 «lipl«l 10 no
• [let
IddltlODll llltl ITlillbl*.
BtlltS; TMCI ElBBBRS; 4ISBIIC;
BIOaiBB; CltCIOli CBLOBIIE; COBALT;
ciBoaioa; CBsioat COPPBB; BBJCOBI;
ICEXBB; POTISSIOB; BUatlBSB; SOOIOB;
IOBIDIOB; SIIBIIOB; H«C; OBIIB;
BtkSOBBRBBT BBTBODS
BBPBBBBCI |
1
PCCkOM. i.K.
T«Un41i, J.I.
Dl«nu, B.
1977
COEB«11«. D.
SDMCk*. 1.
BO«t«, J.
1975
Ul
-------
Butanaalde, l-(2,«-dlaethylpb»nyl|-2-(ethTlpi:oprl»»li>t>)-, (»-) -
36631-U-O
CU-S28-I2-O
It 2T6.«2
TISSOB
Heine
BIPOSII1B BODTB
Ingest Ion
H1LTTIC1L
RETROD
OC/SS
IURBEB
or CISBS
1
BtlOB
a) lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
e) lot applicable
f) lot applicable
9) tot applicable
BEtl
al 0.21*
b) 9.5*
c) 0.»S*
d) 0.«6*
e) 8.3*
fl 7.3*
9) 5.0*
GliniL Tirol R1TIOI
a) BtldocalDC
b) 2-kilBO-2'-bntTtozrUdlde
c) 2-l-Bthrlailno-2>-batrroiilidlde
d| 2.6-DiMtkrlaniline
(| Unidentified aetabollte (actuated
falae)
9) Unidentified aetabollte (atluted
f of 150-19 *«•• eicceted after *8
It.
DIOOS; OITIti RSTIIOITTES
BErEBEICB
Thou«, J.
Bocgan, D.
Tine, J.
1976
1
VO
-------
Bltaaolc acid, 2,3-dibydi:o»y-2-(1-«etbTletkyH-, (2,3.5,7a-tetrakydEO-1-kydroiy-1B-pyrroli*iB-7-yl) aetkyl eater, l-oxldo, (1B- (1alpka.7(2B*,3S*| .7abeta))-
«170»-76-3
C15-B25-I-06
II 315.B1
TX5SOI
1838
Blood,
plana
1839
Urine
Buosrai BOOTB
Injection
Injection
inLRiciL
BBTBOD
ac-sc
OC-BC
IOBBBB
or cists
3
11KB
•1 2«-2.B Of/ftl
b) 73-3.2 ag/ll
c) 95-7.5 ug/al
d) 350-70 og/«l
125-3000 19
mi
•I lot applicable
b) lot applicable
c) lot applicable
4) lot applicable
lot given
GEIBHL IIFOIMTIOI
•) S Bin- 5 he, »50 tg/uq *
b) S ain-6 hr. 1000 ag/sg •
c) S ala-6 kr, 1500 ag/«g e
d) 5 •!•-« hr, 3000 eg/«g •
lange of eeaai
Patient*, 31-76 yc old, «ith advanced
carclnoaa.
letecalble leakopvnia aad/or
tacoabocTtopenia, aTelosappcosion,
keaopoletic torlclty, aild nraaia.
voaiting. Hild hepatotozicity.
DIOOS; DIOG TBBEIPI; IBOPLISES;
ItllLOIOS; BLOOD PLlSBt; OlIIS;
CBtHOTBBIlPT; CtlCIIOItS
2«-kt ntlaea. 750-5700 ag doaea.
Biccatioa relaed to doae, r-C. 86
(?
-------
Butyric acid. 3-((2-aaioo-2-earboxyathyl| thio) -, ataraoiBowr (8 CI|
L-Cyatalna, s-(2-carboxy-1-aathylathylj- (9 CD
218S1-11-0
C7-«13-i-O»-S
•I 207.27
TISSOB
18«0
Drill*
BXPOSOEE tOOIB
Il>9«itlon
mimcn
RETROD
OC
BlcctrophonaU
IOHBE1
OF CISSS
1
UME
a) 10-20X
b) 60-65*
BB»I
a) lot gitran
b) lot glTan
GEHUl IirOIilTIOI
•I l-acctylatvd (lino acid
t) Pr»« (lino acid
P«cc*ot of original doo* (abcnt 100
•9 oc ~> ««olA9> «Kcc«t«d after 8 he.
>RIIO 1C IDS J mTlBOLITBS; mitt
BSfEURCE
Bogtra, K.n.
Banal«r« E.I.
1977
\0
00
-------
litrrlc «ci4, »-(p-{bi«(2-cklDro«tkyl)«*i«o)pk«»7l)- (a C1J
•aMMbitaioic «cM. «-(bl*|2-cUor«Bliio|- (9 ai
30S-03-3
C1*-l1f-C12-l-02
II 30*. 33. II 6«-«6 C
TXSSOB
1W1
Blood.
plant
•1*05011 100*1
iiumxciL
BITBOD
gc/BS
IOIBBI
or cists
1
UNI
•I aso-»0 ag/al
b) 20-1*30 ag/ll
- aiii
a) lot appllcabla
b) lot applicable
eiiiau xiroiuixoi
•1 Chlocaabicil, 2 tad 8 kc aftac
0.5S ag/kg, oral. 375 ag/al «t 1.3
kc
I)
p-t«-l.l-bl«(2-ehloco«thrl) ]«iiBO-ph«
BTl«e«tlc «cl4, 1.3 »a 3 he kft*c
O.SS igAg cklocubiell. oc*l. 300
•g/»l «t a he. flu! Tali*. BitU*t*d
(coi gcipk.
Pitlmt «ltk chronic lyiphocrtle
DIOOS; CHIOtUllPI; CBL01III OKtIXC
coBKOiost HtsoMnn imaocs; BLOOD
HiSBl; LIOIHXI; IR1BOLXSI;
BR1BOLXIIS
izrnncB
Chug. S.S.
ilCCOI. I.J.
tltWCtl, D.S.
Lu«*m. a.
•alma, P.O.
Sipaa. 1.0.
1980
VO
vO
-------
BitTCOphmai*. «-(«-(p-chlocaphmrl)-*-hrdroxrpip*rUlBO)-«>-flaoco- (B CD
1-Bataaoa*. «-(«-(»-CBloropB«Byl.)-«-hy4roiT-1-plp«rlalByl)-1-H-fl«oropB«Bjl)- (9
5Z-B6-8
C21-B23-C1-F-B-.02
It 315.BS. 9t 1«B-1«9.« C
TISSD8
1«*2
Blood,
a*ra*
-
BIIOSOBB BOOtB
InjtctloB
HIHITICIL
BBTHOD
Bit
IOBBBB
or cists
7
BIIOB
•) 0.90-0.05 ng/«l
b) 1.20-0.10 mg/«l
HBtl
a) lot 9lf«n
b) lot gl»«n
GEIIB1L IIFOBBITIOI
.-
• I B«nq« of >wn« 0.33 and T hr «ft«r
0.5 19 I?, b) Bang* of nans 0.33 and
7 he aftvc O.S *9 H
P«ak« at 0.33 he
7 kaalthT aalw, a owl 22-35 jr
DIOOS; DIDO TBBBtPT) BUX>0 SISOH;
citiroBita; iDotts; COBPIBMITE
HILOHIOIS; BOBBOIBS
BBFEBEICE
Babln, I.T.
Bar«, S.B.
1979
o
o
-------
Cadalaa
7
ca
7»ao-»J-»
ca
iti 112.»o, ir 321 c. ar 765 c, n i •• i« at 39* c, 10 •• Bg at »86 c
TXSSOS
18*3
tdipoai
IB**
Blood
1B«5
Blood
•uosm torn
Ingaatloa
Ingaation
XakalatlOB
_
Daraal
iBkalatioa
1BURXC1L
unoD
us
us
mail
or C»SBS
96
•1 213
b) 216
c» 39
1
•MOB
0.007-0.2*8 09/9 (••«
•1 1-6 ng/g
b) 1-6 ng/g
c) 1-6 ag/g
•I lot applicable
b) lot applicable
c) 7.9-8.1 og/100 g
d| 5.0-17.1 ng/100 g
•) 3.2-10.9 og/100 g
f) 3.3-7.1 09/100 g
(IBIT
mi
0.0*0 ag/g (let)
a) «.S ng/9
bl S.6 ng/9
c) ».S ng/g
•) 5.9 ig/100 g
b) 5.6 09/100 g
c) 8.0 09/100 g
4) 11.05 09/100 g
•) 8.3 og/100 g
t) 5.22 ag/100 g
PtG»)
GBI1IU, IBK1BHIOB
Bo lncc«a«« «itk >g*. Bigkvr in
•lotocs this in BouMlrara.
Iblt* »!• loeldmt rtctili, 0«1U«.
tl
•DIPOSB TISSOBt BLOOD; C1DBIDB; B4IB;
IIUBOXS: IIDIBIS; UTIli BOSCtBS;
(1BCBBIS; THIS; OBHB
a) Japaa. 20-55 jr old
b) B.S.. 18-53 it old. moklBg had BO
•ff«et
c| 3»daa. adalt*. klgk«c 1«»»1« In
>*ok«c«
C«c*oa« of dlffcnaeu In aBalytieal
t€ckBiqa«« BO goto tlta tin
coapari«on« eaa ba aad« bativaa tko 3
coontcici.
Stbj«eta la Japan aad O.S., BO
occapational axposar*. »«»
•aplorma. Sacdiak battery factory.
BtTklSi C1DBIOB; FOOD COITIHRtTIOI;
TOBICCOSi SBOIXBG; 16B: SBIj
CCBPlBtTITB ETltOlTXOBS: LIT IB J
IIDIBIS; PaBCBBIS; OBTBBi BLOOD;
FICBS) JtPkB; OBZTBD STiTBS: TBUS;
3IBDBB
a) 1972
b| 1973
c) 197*
d) 1975
a| 1976
f) 1977
lie lavala acoat 0.2 19/00 a cd dnat,
0.1 ag/ea a Cd faaa. 0.2 ag/ca a
Sa02, 1.0 ag/cn a B2SO* aad 5.0 ag/co
a BB03 foi«.
•9-rr-old ckaaleal plant vockar (1966
to 1975) aipowd to Cds, aalinida
ant. aoaa aolabl* Cd coapoanda.
traatad for Pb poiaoBiag. 19CS.
laaaltada, inaoanii, llgktkaadadnaaa,
kaadacka. aaacla ackaa, joint pain.
[acaatkaaia in fingara, iapotanca,
algniflcaat iwigkt loaa.
Hid llur anlargaaant rtth poaaibla
eicckotlc pattern aad calclfiad
gcaaaloaa on laft ling.
BIT1LS; C1DBIOB; LBiD; SBLBBIOB;
tlBC; BlOODj DIIIB: XtDBBTS; BBTkl
(CISOHIOJ OCCOPlTIOBIL B4ttBDS;
ICOLTS
BBFBUBCB
Koial, B.B.
Johnaon. D.I.
Kcaaaac, D.F.
Pahran, B.I.
1979
Kjillatroa. T.
1979
Laraar( s.
Boag. C.D.
Boxian, B.C.
1979
-------
CadSlQI
•»MO-»3-9
Cd
It* 112.10. HP 321 C. BP 765 C, TV 1 II If «t 39« C. 10 » Bg at «86 C
(COWTIIOBD)
TIMOR
18*6
Bleed
ie»7
Blood
ia»a
Blood
RIP030RI ROOTS
Inhalation
UlLRICU
•moo
IIS
IDBBB1
or cis BS
•1 26
b) 19
d n
d) 5«
•) 37
fi 17
91 3"
kl 38
11 1
1) '
1
•1 90
b) 90
c) 25
urns
a) 1.30-4.27 ppb
b) 0.96-». 79 ppb
c) 0.2-2.1 ppb
d) 0.3-3.5 ppb
•) 0.2-1. ppb
f) 0.3-1. ppb
g) 0.2-1. ppb
h| 0.2-1. ppb
1) 0.1-1. ppb
1) O.S-3.S ppb
lot given
a) let given
b) lot given
c) lot given
BBll
a) .36 ppb
b) . 16 ppb
c) .9 ppb
d| .8 ppb
•) .8 ppb
f| .68 ppb
g) .62 ppb
h) .66 ppb
1) .65 ppb
1) I." ppb
7.3 ag/100 ml
a) 0.6 ag/100 si
b) 2.5 ag/100 •!
c) 2.6 ag/100 «1
GEIII1L IBTOIBITIOI
•I 0-3 yr old hospital patients
b) a-6 TC old hospital patients
c) Residents < 1 k« fcos sselter. age
2-3 ye
d) Residents 1-2 ks fcos sseltec, age
2-3 yc
e) Residents > 2 ks (con sselteri age
2-3 jr
() ige 2-3 TC, blood f b < 100 ppb
g) ige 2-3 fc, blood tb 101-150 ppb
k| Ige 2-3 jr, blood Pb 151-200 ppb
1) Ige 2-3 re. blood Pb 201-250 ppb
j) Ige 2-3 re. blood Pb > 250 ppb
Oitck sabjects aged 2 so or elder.
BtTlLS; C1DBIOH; CCPPd: 1801; LHD;
aiioiiESi: ziic; BIOOD; Bioor SBBOB;
38CKIIO; Olll COITHCSPTITB5;
IIDD5T1IBS; SBBLTUS; aOOLTS;
CBILDBBl; SKI; IBTBBW.HDS
Patient ssplcred at pigsent factory
in Instcalla 11 yc. Had history of
keavy snaking and dclnking.
Increasing dyepnen on ezecticn.
coagk. and pacnlent spatas, scats
fcconckitis, crotelnacla and raised
clasna cceatinlne and area levels.
IRILSi CIDBIOR; BLOOD; OCCOPITIOIII.
BIIIIDS; B8TIL POISOII 10; lOSTIIlIlj
CISB BISTORIBS
a| Controls
II Bean eiposwe tin 7.5 yr
c) Bean eiposace tise 27.5 yc
Icrkers in cadnian-asing and
cadslas-pcodeelng factories, Belgian
Coagk, ispnirsent cf respiratory
fnsctioi, and proteiaaria of sized
tsbalar/gloseralar type. lidney nor*
sensitive tkan Isng.
lenal ekanges (tabular and gleseralar
dysf auction) foand salnly in xorkecs
hat lag klgker tkaa 1 ng Cd/ICO si
Hood and 10 sg cd/g cceatiaine in
nrlne.
BIlOIBBj BlOODj CkBinil IID03TUI1
PI IBIS i occnwxoBU niinsi
PIOTIXISi BRILSi nilB
RirEREICK
Zielhais, B.t.
del Castilho, P.
Berber. B.P.R.
liboro. l.A.E.
1978
Beerkin, a.
Clarke, I.
Ollpkant, R.
197C
Laanerys, R.R.
Reels, H.I.
Backet. J.P.
Bernard, 1.
Stanesca, D.
1979
(HIT PIOB)
O
N)
-------
7««0-«3-9
Cl
»tl 112. W. B» 321 C. D» 7C5 C, n 1 •• Bg at 39« C, 10 •• Bg at M6 C
(COBTXBBBBI
Tissn
18«9
Hood
1850
Blood
1(51
siooa
1852
Blood,
•hol«
snosBtB BOM
lakalatioa
lagaatlon
Infection
takalatloa
kULmcki
IBTIOD
us
us
us
us
mm
or cases
11
a| 1(9
b| 1((
a) (3
b| 123
7 aaokara.
8
aoa-aaokar
a
IMOI
•1 lot applicable
b) 9-11 09/100 al
cl 13.3 » or - 0.38 to
1«.S » or - 0.52 a?/ WO
•1
8) 1«. 1 » or - 0.90 to
22.2 « or - 1.95 ao/WO
al
•) (.9 » or - 0.«9 to
18.8 » or - 1.21 ag/WO
al
Saagaa of maaa
a| 0.015-0.323 ag/100 al
b) 0.021-0.330 ag/100 al
•) lot gitaa
b) Bot gl»«n
a) 7.3-67.2 e«/l
b) 8.0-62. 6 ag/1
c) a. 9-io.S 19/1
d) 1.3-13.2 ag/1
(KIT
HUB
a) 0 ag/100 al
bl 10.0 ag/100 al
cl 13.9 ag/100 al
41 18.2 ag/100 al
•1 13.7 ag/100 al
al 0.0903 ag/100 al
b) 0. 1075 ag/100 al
•1 0.093 » or - 0.115
ag/g
b) 0.076 » or - 0.109
ug/g
a| 22.7 ag/1
b| 18.0 og/1
c| 7.0 ag/1
d) 6.9 ag/1
PICK)
CBIIUL XBFOSBhTXOB
•) * aa« aarloycaa. atart of Ktady
b) 3 B«W aaplor*«a. daf 120 of atadj.
•alaaa aatlaatad troa graphs
el 2 ••ployad 23 »k at «ttrt of
atadft obncvad Bast 11-12 »k
4) 2 •aployad 75 aad 76 >k at atart
of atady, obaarrad uxt »• «k
•1 3 «BplOT«4 188-266 «k at ttart of
atadr, ob*«c«ad a«rt 36 ak
Bloo Cd ineraaaad to 120 daya taaa
l«al«d. Oclm Cd ap daring 0-15
4af« of azpoaan, aor« aloiil] 15-120
dtya, rapidlj after 120 daja
Iddltioaal data on «zpomc« 1*T*1>
•ad klda*} fanctloa.
laployaaa, 2«-*7 ji old. lorklag «ltb
CdO aad Cd aalta. 2/a aa« aaplofaaa
aad »/7 old aaploycaa aaok*4 >19
cigar* tt«a/daf.
lockaca ultk longcat daratloa of
•ipoaara akond klda«y dlatatbaac*'.
anus: cioixni: ami FOISOHBOI
HOOD; OIIBI; OCCaltTXOIU BHIIDSj
XBOOSTBIkL kTIOSPBIBIS; XBDOSTBUL
IHXIBRi COBIUkTXfB IVU.OITIOIS:
BIOkCCBBOLkTXOB: BBTkBOUSB; SBOCIBai
Bitaios
•1 S«bj«cta froa Chicago. 197«
bl sabjacta tcoa Chicago. 1976
1CIPOSE fXSSDI; BLOOD; ClDBimi; BkXB;
IlLIIOIS; RXDBBXS: tl»8k; BBSCUSI
(HCBBtS; TBIIS; OBXBB
a| Batacaal
t) total
Bey »t baala
Saaplaa ftoa a hoapltala In
BaakvllU, TI.
HkCBBTk; IB1U.S; TllCI B1BBXB1S;
TIBBBSSBS: BtOOD; BkXB; COBPUITIfB
BfklDITIOBS; BBBCOBT; IBlOi C10HIOB;
SIIBIIOB; BBBXOXOI: XBOB: SXBC;
COBtLT
•1 Saokaca. bafor* vacatloa, aaaa
aecklag tlaa 5 jc
t) Saokcra. attar 1 ao vacatloa, aaan
aorklag tiaa 5 yr
el loa-aaokara. batora Tacation. aaan
aorklag tiaa 9 yr
4| lon-aaokara, aCtar 1 ao facatloa.
aaaa vorkiag tlaa 9 yr
tattary factory «ork«ra, 28-CO yr
old.
CID8IOH; BET1LS; IBDOSTBItl
ItHOSPBBBBSi S8OIIIO; BLOOD: OBIBB;
COBPtlkTIVB ETklOtTIOBSi OCCtHTIOUL
lltiROS; SBtDBB
UTSBIBCI
Laa«ary«. B.
Boala, B.
sagalara, B.
Backat. J.P.
Barnard, 1.
Oocat, i.
1979
Koval. B.B.
Jokaaon, D.B.
Eraaaat. D.F.
Pakcaa, B.B.
1979
Baglaa. B.J.
BCOl, k.B.
sckalart, k.
Illaon, o.
Laraaa. I.
Dyar, B.
Baaaoar. B.
schaffmct B.
Boffaaa. L.
Davlaa. J.
197a
Idaaaaon, B.
Placator, a.
Bogaia, K.
1979
O
CO
-------
Cadalna
Ct
»tl 112. »0,
IP 321 C, BP 765 C, TP 1 •• Bg at 39* C, 10 •• 89 at «86 C
(COITIIDEDI
TISSDB
1853
Blood,
•hole
185*
Blood.
•hole
1855
Blood.
•hoi*
1856
Bale
EiPostrsB BOOTS
inhalation
ingest ion
_.
Dersal
Inhalation
Inhalation
Ingest ion
miTTICU
HBTBOD
MS
US
us
us
BDBBBS
or CUBS
35
69
•I 38
bl »8
_
•1 9
bl 1
lalQI
a) 0. 15-«. 3 09/100 il
b) 0.19-0.21 og/100 ml
lot given
a) 0.02-0.35 usoles/1
bl 0.01-0.18 aaoles/1
•) 3.»5-13.« og/g of
Cd-positlfe sections
b) lot applicable
(HIT
HEX
a) 0.93 og/100 il
bl 0.38 09/100 il
0.36 og/dl
a) 0.10 osoles/1
bl 0.07 nsoles/1
a) 7.31 09/1 of
Ca-podtlra ••ctlon*
b) 2.73 09/9 of
Cd-poaitlvi ••ctloas
USB)
OB1EB11 IIPOBfllTIOI
al BipoMd leckcri, c«oq« foe 9
•abject*
b) OncxpoMd «ock«n, rang* lor 2
aabj«ct>
L«»»la correlated Kith length of
eaplofient.
lockers, exposed aad nnexposed. la a
handiade-jenelrf plant.
DT'pnea, chest pain, dyaotla,
dinloes*. Irritability, headache,
catlgae, nasal eonfestlon, dry soath,
cclyarla, aaoiala, ere Irritation.
•ETtLS; C1DIIOB; OCCOPlTIOIil
BIIIIDS; BIILTB BIHBDS; BBT1L
pcisonio; BLOOD: OIIIB: itii: IEV
BIIXCO
lead saelter corkers
lean age 42.5 fr, cean esplo]me«t
11.3 yr. In California.
amis; IBID; HBSBIIC; caOBinai
Btooo; komtsi occopmaiii ucitosi
CCBHIaTXTE tVilDaTIOIS; CiLIFOIIXI
a) Cacdtofaiealac patients
b| loreotenslre controls
lo apparent effect of age.
Patients nith aoderate to sewre
cardiac conditions and/or
hypertension, controls with no Itnonn
cacdioTascolac aya[ton*. ill over 30
yt old.
IITUS; ODBIOB; LIID; CHDICTlSCaLU
CISB1SBS; OIIIBD IIIODOS:
BIFEITBISIOI: 101; IDOltSt S BOH 10;
CCBP1MTITB BT1L01TIOIS; BLOCOi OIIIB
a| Biposed vcckers
b) nnexposed eorker
levels higher in sections farthest
Ins scalp and In sections grom
before exposmre than daring ezposore.
lockers, exposed and anexposed in
hudaade-jeeelrr plant.
Dyspnea, chest pain, dysnria,
diHiaess, Irritability, headache,
fatlgae, nasal congestion, dry soath,
(Olyarla. anosnla, eye irritation.
IRltS; CtDBIOB! OCCOPatlOIll
imiDS; BB11TI UX1BDS) BBtU.
fOlsoino: liooo; 01IIE; Bill; Ri
BIIICO
BBfEBEICE
Baker, 1. 1.
Peterson, I.I.
Bolts, J.I.
Colesan, C.
Landrigan, P.J.
1979
Spivey. G.B.
Broun, C. p.
Baloh, B.I.
Canpion, D.S.
Talentine. J.L.
Bassey, r.j.
Broidy, B.I.
Calver, B.D.
1979
Khera, ».«.
libber ley, o.s.
Edvards, I.I.
laldron, B.I.
1980
Baker, B.L.
Peterson. I.*.
Bolts, J.L.
Colesan, C.
Landrigan, P.J.
1979
-------
Cadalaa
7«»0-*3-9
ca
Itl 112.«0, IV 321 C, tt 765 C. ¥P 1 •• Bg at 39* C, 10 •• Bg at *86 C
(COITIIOBD)
IISSOB
IBS?
Bale
1858
Bale
1859
Kidney
I860
Kidney
1861
Kidney
1862
Kidney
Binsni icon
Ingeatloa
IngeatioD
Inhalation
.
Ingeation
IIU.TTICIL
BBTBOD
US
us
us
us
us
us
BOIBII
OF CaSBS
a) 179
b) 108
C) 102
4) 109
a) 228
b) 189
a) IS*
b) 16*
c| 285
91
162
91
•1MB
a) lot given
b) lot given
c) Bat given
4) lot given
•| 0.06-9.9* ag/g
b) 0.06-1*. «0 ug/g
•1 1.2-82.6 ng/g «et it
b) 7.«-26.3 ag/g «et it
c) 1.3-29.0 ag/g «et nt
Bug* of eeana.
1.0-«0.3 ag/g
2.97-108.66 ag/g (net)
1.0-100 ag/g vet «t
(HIT
mi
•I O.TT ag/g
b| 1.1* ag/g
c| 0.96 ag/g
A) 0.62 ag/g
Oeonetric leans
•) 1.098 ag/g
b) 0.828 ag/g
a) *0.7 ag/g ««t «t
b) 17.8 ag/g mt *t
c) 18.1 ag/g rat «t
16.8 ag/g
20.99 ag/g (««t|
2* ag/g wt »t
PIG!)
SBIIUL IROBB1TIOI
a) BaU cklldnn
t) F*aal* eklUc«B
c) Sal* afltlt*
d| r*aal« alalt*
CocolatloB batvMD C4 and a«.
IdditloDal data.
Scalp kalr> Caacaaiau In 11, agaa <1
to gr*at«r taan 51 Jt.
BITUS; TB1CI BlIBIBTS; BtBIOBt
B010B; CiDBtOH: CBBOBXOB; COtPBBj
1101; tB»D; LITBIOB; BHGllBSE;
BllCOBt; 1ICIBL; SEIBIIDBJ SILTBB;
TIB; TaBaOIOB; MBC; BUB; ICE;
1DOLTS; CBXUBBB; SBX; COBMUTITB
BliLOlTIOlS; DOSTt SOILS; ill
MLLOTIOB; OIBaB ilBIS; IBB 1O»K
•) sabjact* fcoa Chicago, 197*
b| sabjacta (coa Cklcago, 1976
IDITOSB TIS3DB; BLOOD; CIDBIOB; BIIB;
IlLIIOIS; IIDBITS; LITBB; BQSCLBS;
IlKlEtS; tills; OBIBI
a) Japan, 1-79 jr old
b) O.S., 10-59 yi old
el S«adan, 2-89 yr old
lalvaa for coctax. Laval* incraaa*
to aga *0-60 than daccaua.
loB-oecapatlonally axpoaad victlaa of
acctdantal ot aaddan d«atk.
BITllS; CaDBIOB; FOOD COBTaBIBMXOBi
TOB1CCOS; S SOCI IS; aGB; SBI;
CCBPlBaTITI BValOkTIOBS; IITIS;
KIOBBTS; HBCBIaS; OBI IB; BLOOD;
PECES; JlPiB; OBITBD STITES; IB IIS;
SBBDBB
Post aoctaa, aabjocta 6 aontka to 93
yc old, froa Briabana, laatcalia.
BltlLS; C1DBIDB; LUD; KID1BTS;
01I1B; OCCOPITIOBI1 RH1BDS;
IOSIBILII; COBPkBHIfB BT1LOKIOBS
Coctax. cd inccvaaas ilth ag*.
Blgkac in aaokeca tkan in nouaokara.
Iblta an la aeeldant victiaa, Dallas,
11
IDIPOSB IISSOB; BLOOD; CiDBIOB; BITS;
IllIBOIS; HOIBIS; tlTES; BOECtBS;
IllCBBIS; TBIIS; OBIBB
Coctax. Lavala inccaaaa op to aiddla
aga, then dacteaa*.
latopalaa of aalea, aged 2 ao-88 yc.
and faaalaa, aged • ao-9* yc( in
Cacth, (eatecn taatcalia.
BITILS; ODBIOR; IITEB; KIDIITS;
IDSTB1LH; IDTOPSIES; BIOJkCCDHOUTIOl
BBFBBBBCB
Ccaason, J. P.
Hinnaca, I.I.
Baagacnar, J.E.
Pinkecton, c.
1975
Botal. B.B.
Johnaon, D.B.
Kcaaaac, D.F.
Pabrm, B.B.
1979
BjelUtcoa. I.
1979
Billec. 6.J.
lylia, B.J.
BcKaotn, D.
1976
KOMl. B.B.
Johnson, D.B.
Kcaaaac, D.F.
Pahcen, B.B.
1979
Spickett, J.T.
Laznac, J.
1979
I
o
Oi
-------
CKiUl
tt i«« .•. 10 •• Kg it m c
(COITIIOID)
ttliii
ii4i
IUMT
1M«
«i4ii«T
IMS
ll»«r
1444
lltct
Mtosa«« ictatt
IigaMioi
UUUtloi
mktlitloi
•— ssintini —
RPTROD
lit
II
tkl
ioSIii
ar cuts
il n«
W 71
0| It
tl m
b| 1««
a) MS
1
utai
100-100 ««Al
t) tat gl»«n
bl tat «i««n
a) lot gl»»n
t) 0.4-4.0 ig/i rat it
b) O.II-U« •(/« rat lit
a) 0.«4-».JJ «»/« rat lit
nB«* of ••»*.
let ipplletbl*
«!>•
tot glicn
•1 «].* ppi
k| tt.i pp.
a) It. I ft*
•_- ---
•1 ).)« «t/g »t «t
b) 1.JO «g/« nt »t
a) 1.10 ««/« vat it
0.1] if/100 9 o«t «t
I . _ . ._
attim itrotttfioi
i«»l> ibont 10 tin* *ori*l
Itildinti at >klph», aoU»d Kligiloi,
ttTUtl CtOtTOt) tlOtlTl) IttORtttL
ICllOTIQII IIOOIttllL Itllll LtID
tOlUTIOIl tUIVtllltT tlTNOU)
tatdlkTIOt IINlOttl DRITIB ITIOOOK
t) to m*l 4l>«*>«
b) loit* mil fillirai
C| cktoRle mil tttlim
• 1 »4 0) tttncot, KO.OJ
«•!»• >ti ttj «t bull.
UtOplUl >t OCL» DoiplUl.
TllCt Ultlim IITIUi kOTOniUl
ciiirottik) tiotiiii ttftti it mil
oiiitiui iitntiiixoii taptoti
lOTItllOl! MUIIII tlOlttOIOSi
iiiiitnii ctotiati utci cortiti
moi not) iiiatiitii itotitom
IIIICOII tttlllOII COIIITI tlCUtl
latittiioti tin cnomn iitoniom
iitioti itriioii tuftti ntiDimii
totet
1) jMllt I-1* ft 014
b) 0.1. . 10- J» yt 014
o) Iioaai. 1-lt it oU
Uvoli lioraM* to flitMi mtk •»«.
loi-oaaititloiillT HPOM4 tlc t«l» «»4 •wllai
kllMfi. tofoiicitui at liif
•tltkolUi. n»lU« o*ll iwniU.
ciotiin •iimi»i unui MTU
toxionm initi totin titctint
.. .
• »rii»li«r«
for»«n, 1.
l«nn
IndrftprkBil , S.
tl«i*nd*r, a.l.
oontcl, K.r.
1«T«
Xlallitroi, T.
1»1»
ttt««r4k», J.I.
fliokk, t.l.
1*14
inn »utr
-------
OttalM
itt MI. to. it Hi c, » TIS e. it i •• if •* it* e, 10 » it •» »i« c
nun
1117
Umr
llll
Lint
,. ,
lilt
1110
U»9
iwoimi Botii
XtfOltlOt
inktUtlo*
iikLTTickL
IITIOD
III
III
n
~ iiiiif
or cnu
„.]
in
it
•1 11
k) «1
o| IS
1
mill i
i
O.Ot- 1. II «g/g (nt|
0.1-7.* if /i tot «t
*) lot olvon
b) lot ai*oft
o) lot fifoi
(OUT
nil
1.11 «t/a («•*)
1.1 i|/« ««t it
k| »!o pp«
a) M.I pp*
0. IS ig/tOO « «*t vt
MOD
4IIIIU IlKIRkfXOI
cd lBoc««m« likk *fo. llfku U
ItOlWH tk«t It tOIMOkW*.
Iklt* ••!• toaldtit vlotlii. Otllto,
tl
loxtaii tuioii UOODI cioixwi ntn
XUIIOIII IIOIITII mill lOKLUl
tIKIIIIl TIIUl 01X11
IttOBiloa ot wlM> »««d 2 »o-ll yc,
•td fouloi. «tod * io-t* jt, tt
toctkt loiton l»»U»ll«.
IITklll CIBITVII lltlll RIDIItll
IIITIILXII lOTOMXUl IXOICCIiailtXOI
I) 10 Mtkl dUOtll
k) losto (•••! ttlltm
o) Ckcoklo t«ti talltni
It Ml 0) dlttOMlt, f<0.01
tltaplUl *t OCU KMplttl.
tlkCI UIHIItll IITkUl lOTOIIini
ciuranxit IIOIITII ufiii man
oiiikim mmiiiioii IODXWI
totkiixaii eiuxoii iioiMoimi
lltlllHIl CkDIXOII IXICl COWIIt
iikoi noi| ikiikinii uoixniii
ixiicon Txnixoii coiktti IKMH
lOiiioiiDii mi cuoiioii inonxon
ikiioii inmii niTiii Tkiioxmii
ICIOI
kikopoi
Sl-jfr-old ••> *«ldl>« cd-pl«t»d dra»
•itkOM pNOMtlao* tgtlnit t««M.
Iktoit Iccltttlan. kcvttklii
dlttlOlltUli (•«•[. CifOCI.
IflBIMUt OftkOtlO. t*MllO,
in«tlii, ««»kU to mlk, UMlnd
•••oak, tteld pii««. M*«k ditl»«
Jtd ««|.
Hltc«m«a% ot tko k««cki BIUOMCT
««••», attdiia ktroit. liUifvd t«d
fiOlfWMd ••l«0«( Mlo »Bd IIOlUR
kltkoi*. d«t«i«cttlot ot !«•«
tpttkoiUi, kopttlc ooll noacoiU.
Ckoiiom koinkiiki IITHIII nni
texioiiioi imii taian kotctini
lirlincl
MMl, 1.1.
Jokiooi, O.I.
(noHc. o.r.
MklMi I.I.
ItTt
iplakott. J.T.
Untr. J.
ItTt
XtdctprMlt. 1.
kl«IUd*C, «.?.
•oalak, i.e.
im
ntntrdkt*. J.i.
ruakk. I.I.
im
-------
Ca4ii.ui
7MO-U-9
AM 112.«0. BP 321 C, BP 765 C, TP 1 •• Hg «t 39« C, 10 •• Hg at «86 C
(COBTIBOED)
TISSOB
ie7i
luele
1872
Basel*
1873
Pancreas
187«
Pancreas
187S
Placenta
EXPbsOBE BODTB
Ingest ion
Inhalation
Ingest ion
Ingest ion
Inhalation
iBgestlon
AIALTTICAL
IIBTROD
AAS
US
AAS
AAS
us
BDBBBB
or CASBS
al 209
b| 16*
C) 61
162
162
135
PUCE
a) 50-570 ng/g net «t
b) 30-95 ng/g net vt
c) 6-1M ng/g vet «t
Bang* of seans.
0.001-0.256 ug/g (vet)
a) Bot glT«n
b) Bot given
c) Bot given
0.05-1.90 ug/g (vet)
Bot gi»«n
(BBXT
HEAB
al 293.6 ng/g net *t
b) 57.) ng/g net vt
c) 6*. 6 ng/g vet «t
0.067 ug/g (vet)
a) 2. 2 ug/g vet vt
b) 0.7 ug/g net it
c) 0.5 og/g net «t
Geoietclc leane
0.58 ng/g (net)
0.102 » or - 0.077
ug/g
PlOE)
GEBtBtL IBPOBIHTIOK
a) Japan« 1-79 jt old
b) O.S., 10-59 ji old
c) Sveaen. 18-69 re old
In Japan and Sweden nocen a«ull]r
bigher levels than sen. Increase vitb
age in sen.
Bon-occnpationally exposed victiss of
accidental oc sadden death.
BITILS; CADBIOB; FOOD COBTtBIBtTIOl;
TOBACCOS; SaCKIBG; AGB; SEI;
CCHPABATITI BV1LOATIOBS; LITEB;
KIDBETS: PABCBBAS; OBIBB; B100D;
IECES; JtPtB; OH IT ED STATES; TEXAS;
SIEDEB
'Cd increases with age. Higher in
•solcecs than in nonssokecs.
Ihlte sale accident victiss, Dallas,
TI
ADIPOSE TISSUE; BLOOD; CADBIOH; HAIB;
IIIIBOIS; KIDBBTS; 117 BB; BOSCLES;
PABCBEAS; TEXAS; DBIBE
a) Japan
b) O.S.
c) Sveden
All 30-59 vc old
Bon-oecapationallv exposnted.
BETALS; CADBIOB; FOOD COBTARIf ATIOB;
TOBACCOS; SROKIBG; AGE; SEI;
CCBPABATITB BUIOATIOIS; LITEB;
KIDBETS; PABCBEAS; DRIBS; BLOOD;
ItCES; JAPAB; OBITED STATES; TEXAS;
SIEDEB
Cd increases vlth age. Bigher in
saokers than in nonssokers.
Ihite sale accident vietiss. Dallas,
TI
ADIPOSE TISSUE; BLOOD; CADRIOB; BAIB;
IlLIBOIS; KIDIETS; LITEB; HOSCLES;
PABCBEAS; TEXAS: DBIIB
Dxv vt basis
Saaples fros II hospitals in
Bashville, TB.
PLACEBTA; BETALS: TBACE BLEBIBTS;
1EBEESSEE; BLOOD; BAIB; COBPABAHTE
IfAlOATIOBS; SEBCOBI; LEAD; CADRI08;
SILBBIOH; BOBXOIDIi IBOB; SIBC;
COBALT
BEFEBEIICE
Kjellstros, T.
1979
Koval, B. E.
Johnson, D.E.
Kraeser, D.P.
Pahren, H.B.
1979
Kjellstros, T.
1979
Koval, B.E.
Johnson, D.E.
Kraeser, D.P.
Pahren, B.B.
1979
.. -
Baglan* B.J.
Bcul, A.B.
Schulert, A.
Illson. D.
Larsen, K.
Dyer, B.
Hansoar, B.
Schaffner, f.
Roffsan. L.
Davles. J.
197a
o
oo
-------
CadalUa
cd
Itl 112. 49, BP 321 C. BP T65 C. It 1 aa Bg at 39* C. 10 •• Bg at 486 C
(COHTIHOBD)
TISSUE
1876
Spleen
1877
Teeth
'
1878
Orine
1879
Ocine
1880
Orine
Ezposon MOTS
iBhalation
Inge at ion
Inhalation
tllLTTIClL
BBTBOD
IS
US
its
us
BOBBER 1
OF C1SSS j
a) 89
b) 3«
C) 73
a) 28
b| 28
a) 7
b) 8
a) 607
b) 86
c) 108
a) 55 u
b) 239
BalOB
a) lot gii«n
b) lot glrm
e) lot given
a) lot given
b) lot given
a) 1.0-1*. 7 ug/g
creatinine
b) 0.5-9.3 ag/g
creatinina
a) 0.42-2.04 ug/1
b) 0.33-0.80 ug/l
c) 0.17-0.71 ug/1
Bange of aeans
a) < or • to 1 ug/1
b) > 1 ug/1
Bill
a) 6.58 ppa
b) 12.0 ppa
c) 8. 38 ppa
a) 4.3 ppa
b) 4.4 ppa
_
a) 5.5 ug/g
ccaatiniae
b) 3.6 ag/g
creatinina
a) 1.58 ug/1
b) 0.57 ug/1
c) 0.41 ag/1
a) Hot given
b) Hot given
GEIEBIL IIPOBB1TIOI
a) lo r«n»l disaaaa
b) teat* canal failara
e) ckconlc canal failure
a) and b) different, p<0.01
Talma ace dcr «t basis.
lotopaiaa at OCL1 lospital.
TB1CE BLBBBITS; BETlLS; lOTOfSIBS;
CILIFOBIIl; KIDHEIS; LITSB; SPtBBI;
DISBaSISi BTPEBTEHSIOH; SODIOB;
tOTtSSIOBi CILCIOB; PBOSPBOBOS;
B101E5I08: C1DBIOB; IIHC; COIPEB;
l»D; IBOI; RalOaHISE; liamiOB;
SILICOI; TITHIOH; COBIIT; IICKBL;
B01TBDBIOH; HI; CBBOBIOB; SIBOniOH;
BIBIOB: LITBIOB: SILTEB; T1IIDIOB:
(CBOI
a) HE Bristol
b) SI Bristol
Cacaanant pceaolac teeth collected
fcoa school dental clinica lc
Bristol, Onited Klngdoa.
BITUS; LEID; ZIIC; CIDBIOB; COPPEB;
1IBTB; CBILDBBH; OIITED ItllOCOB
..
a) Siokera, lean locking tia< 5 yr
b) Bon-aaokeca, aean working tine 9
jc
liter 1 ao vacation.
Eatt«cy factory vockers, 28-60 yr
old.
CIDBIDB; BETILS; ISDOSTBIit
ITBOSPBBRES; SHOKIHG: BLOOD; UBIRE;
COBP1BHTIVB I?tLDlTIOHS; OCCOPtTIOHkL
H»tBDS; SIEDER
a) Japan, 0-90 yc old
b) O.S., 1-7C yr old
c) Sveden, 0-89 yr old
Japaneaa and Swedish noaen of certain
age groups bad higher levels than
aan. Saokeca, higher urine values.
Hon-occupationally exposed.
fltULS; CID9IOB; FOOD COHTtHIHkTIOH;
TOB1CCOS; SBOKIHG; aGE; SEI;
COnPHRtTIVE ETkLOtTIOHS; LITER;
RIDIETS; PtHCBEtS; DBIHB; BLCOD;
IECES; JkPkH; OHITED STITES; TEUS;
S1EDEB
a) Pb levels of < 50 ug/1 in 128 of
554 saaples
b) Pb levala of > 50 ug/1 In 16 of
234 aaaples
tcprox 1:10 ratio of cd to Pt
throughout range of values.
Indiana hospitals, and the Indiana
Oniveraitv Bedical Center,
CIDHIOH; LEkC; ORIHE; BET1LS; IHDItHt
BEFEBEICE
Indcapcaait, S.
llexander, G. T.
Gonick. B.C.
1974
Stack. B.T.
Bnckitt, l.J.
•ickless, G.
1975
Idaasaon. E.
Piscator, B.
Hogava, K.
1979
HJellstroa, T.
1979
Levls, S.C.
Forney, R.B.
1976
(KBIT PUGE) -
O
VD
-------
Cadalaa
7C.»0-«3-9
ca
Ul 112.40, IP 321 C. BP 765 C. Tf 1 •• 19 at 39* C, 10 •• Bg 4t «8« C
iconinio)
TXSSOB
orlae
188J
1883
oclna
1BBB
i
BXPOSOU ioni
Inhalatloa
XagaitlOB
aerial
xakalatlaa
kBUTTXClL
IBTBOD
US
us
us
•OBBBB
OF CUBS
9
1 " •
•1 32
b| 17
a| 76
b) 22
UISB
lot given
.
a) lot applicable
b| 7«.o-122.0 ag/1
c) «3. 0-120.0 ag/1
d) lot applicable
e) lot applicable
a) lot gives
b) lot gives
a) <0.5-B.O ag/1
b| O.5-2.5 ag/1
(HIT
mi
>• ag/1
a) 5.2 ag/1
b) 98.0 ag/1
c) 103.0 ag/1
d) *0.0 ag/1
a) 77.0 ag/1
a) 22.* ag/g
creatlniav
b) a. 9 ag/g
ereitialBe
a) 2.0 agA
b) 1.1 ag/1
PMBI
ellBML XIFOSBaTXOB
9/36 caadoi aaaplea kad detectable
levela. Be correlation betaeaa level
Bad leagtb of eaplcy aaat.
Barkers, espoeed and aaexpoead, IB a
haadiaae- jevalry plant.
Bvspsea. cheat pala. dyaaria,
dixxiaaaa. Iccitabilitr. headache,
fatigoo, BBIBI congestion, dry Boatk,
polysrla, anaasia. eye icrltation.
BITUSi C1DBXOB; OCCOPMXOI1I
ItBalDSI BIUTB BMUDS) BBTU
POXSOIIfQ; IMODl OIXBB; BUI; IN
IIXXCO
-
a) 1967
b) 1972
C) 1973
d) 197*
a) 1977
lie level* aboat 0.2 ag/ca a Cd daat,
0.1 ag/ca a Cd faaa. 0.2 ag/ca a
Sa02. 1.0 ag/tta a B2SO*. asd S.O
ag/ca a BI03 faae.
«9-vr-old ckealcal plant «orkar (1966
to 19751 expoaed to CdS. selaiido
daat. ooae salable Cd caapoands.
treated for fb poioonlag. 1965.
laaaitade. inxoanla, ligktkeodedBeiB,
kaadackCf aaacle acke*. joist pain,
(BCOBtkea-ia la flngera, lapotenc*.
algaiflcaat aelgkt loaa.
Bild liver ealacgeaaat vith pacaible
clrrkatio patteca aid calcified
grasaloaa OB left laag.
BIIUSl CtDIIOBi I.UD: SBUBXOBS
tIBC] BLOOD] OBXBIt HBBBISJ BBML
MXSOBXiai OCCOVaTXOlU BtlBlDSl
ICOLTS
»l Udaer ByaptOB«, bat lot boae
•yiptoaa of Xtii-itai
b) Orlaacy pB > oc • 6. BO exeeaaive
Cd expoiare
32 Japaaeee obaervatloa patiente,
aaaa age 70.1 yr. 17 refareaoe
people froi toyaai trefeotara, Japaa,
aoan age 66.6 yr.
ciDixai; BBTU.SI aunt Jitaii
COBflBITXTB BniOtnOBSl DISUSBS
a) oecapatioBOl expoaate
b| la kaan axpomre
kdalta froa Brlabaae, laatralla.
BRUSl CtDBXBBl LIIOl KXDIBtit
oiirai oecotmoiit BISUDSI
issnuiii coBptBknfB mutriois
i
•BFIUSICI
Baker, t.i.
Boltx. j't."
ColeiBB. c.
laBdclgaa. P-J.
1979
Lernar. S.
Bong, C.D.
BOXlOB, B.C.
1979
Shlcolakl. K.
(jallattoa. T.
Xabota. R.
BvclB. P.-B.
Skiiida, T!
rlecatar. B.
Kata. T.
•ilkiao. B.
1977
Biller, 8.J.
tylie, B.J.
BcKeoaa. D.
1976
-------
Cassias
7MO-«3-9
Cd
Itl 112. «0. U 321 C, B* 765 C. t» 1 •• Bg at 39* C, 10 as flg it (86 C
(COITIIOBD)
nssn
uas
BriS*
1(86
Orlne
-
1X7
OClM
iinsm toon
Xnkelstlon
sBsLmCU
BBMOD
US
US
..
IDBBII
or CISBS
•1 30
b) 30
0 »0
6} »0
•1 37
•1 90
b) 90
d 25
4 59
b) ««
cl »6
d) 20
•) 99
(1 52
II 62
III 66
UTCB
•) lot given
b) Bat given
c) Bat gin*
d) Bat giita
e| Bot gives
e) Bot given
b) Bot givn
e) Bot given
a) Bat given
bl Bot given
cl Bat gives
d) Bat gives
e) Bot given
f) Bot gives
Slot gives
Bot given
(HIT
a»
•1 7.» sg/1
b| ».8 sg/1
c) 10.8 ag/l
4) 7.0 sg/1
e) 6.1 ag/1
•) 1.7 ag/g
crest in ise
b) 23.3 ag/g
acestisine
c) 30.7 ag/g
etestinine
s) 6.6 sg/1
b) «.1 ag/l
c| 6.8 sg/1
d) 2.8 ag/l
e) 9.8 ag/l
t) 5.2 ag/l
I) 8.2 ag/l
s) 5.0 ag/l
pion
BBBBMl XBFOBUtXOB
i| csdsiSB iccteca, BsgiMkl sees
b) costrola, Bsgssski sres
c| CsdsiM •ortere. XaUksn sees
d) Costcala, ttkiksvs sres
e) CsdsiM vackere. ttits sres
216 isle •orkeca. 50-70 yr sge, (COB
3 pallited and 3 control sreu in
Jnpss
IsccesMd eicntlos of B«ts(nb|2-
slcEogloballn eocrelste* «ltl botk
sge ssd degree of ezpoimc*. Bo
no-effect level of csdnias fcr
InClaencing lets (sab) 2-eicrogloballn
level.
tail CIDKI00; IBDOSIIItl. M110TIOB;
JHMt initSl OOCOIUXOBU IISUDS:
IIOTBIISI aim
s) controls
t) Beu eiponare tise 7.S vr
c| Bess oxpomro tlse 27.5 yi
lackers is cadslas-aeisg snd
csdnini-Drodacisg fnctoriee, Belgian
Caagbf lensitsent of reepirstocy
(•nation, snd proteinsris of nixed
tabslsr/glaseralsE type. Kidney sore
sensitive tksn long.
lessl ekssgea ftabalsr snd gloseralsr
dycfsnetion) fossd ssinly in worker*
kiting Ugker tkss 1 sg Cd/100 si
blood snd 10 sg cd/g crest in In • in
•cine.
moioB; BIOODI ckcini; i most tin
tltrtS; CCCDVITIOin. ItSIIDS;
IIOTBIISI RITtLS; 01X18
•I Pollated sress - Iklts
c) rollsted sress - Qaass
•I Pollsted sres* - Xikiksus
g| Pollsted area* - Isgssski
1826 persona over SO fros general
popslstlos of * cd-pollated
trefectsre*. 1611 fros * control
[cetectares, in Jspsn. given
•jsteutlc testa.
Clacosarls, lo« solecalar weight
proteinarin, fregaency of decreased
tabslsr resorptlon of pkoapkcro*. and
cndalss in sris* nil kigber in
sabjeete fres csdslas-pollated areas
BIOIIDIC1TOI3; CiDIXOli OBOOR) SITES
fCLLOIXOIl XIDDSTIXI1 POUOTIOI;
JlPtll L1ID POLLOTIOI; POPOLITIOI
IXPOSail; PIOTIXISl OBXIBt PCOD
COITkBXIkTXOli BltsLS
inrnnci
Tnckiys. K.
Xsso, S.
sagita. I.
ssksrai. B.
1979
Isarary*, B.I.
loels, B.I.
Backet. J.P.
Bernard. 1.
stanesca. D.
1979
skigesatss, I.
Blnova. 8.
Toakids, f.
Biyasoto, K.
1979
-------
Cl4si.ni
7»»0-«3-9
Cd
Itl 112.»0. HP 321 C. B» T6S C, TP 1 •• Hg «t 39* C, 10 •• Bj it «86 C
(COITIIOBD)
Tissue
1888
Orlae
1889
Orlae
1890
Orlae
BIPOSOBB BOOTS
Inhalation
xngestlon
Ingestlon
IMLTTICIt
BBTBOD
us
us
_
us
BOBBSB
OP CISBS
11
a) 223
b) 189
c) 86
a) 292
bl 223
IIIQB
a) lot applicable
b) 12-«0 ag/g
c) 3».» » or - 7.0 to
*1.5 » or - *.7 ag/g
d) 181 » or - 21.5 to 182
» or - 9.1 ag/g
e) 109 » or - 19. • to 370
» or - 30.2 ag/g
ag/g creatinlne
_
a) 0.06-5.05 ag/l
b) 0.02-2.06 ag/l
c| 0.11-2.1* ag/l
a) 0->*0.o ag/g
creatinlae
b) 0->30.0 ag/g
creatlolne
i
(BBR
mi
a) 0 ag/g
b) 33 ag/g
c) 38.0 ag/g
d) 181.5 ag/g
•I 201.7 ag/g
ag/g crestlnins
s) 0.767 ag/l
b) 0.636 ag/l
c) 0.59* ag/l
•) 3.6-«7.8 ag/g
erestlains
b) *.0-«1.1 ag/g
creatlnine
Plot)
OBIBIIL IIPOBB1TIOI
•) * nei esployees, start of stady
E) 3 ssi esployees, day 120 of stady
lalaes estinated froa graphs
cl 2 eaployed 23 Ik at start of
stidy, observed neit 11-12 «k
d) 2 eaployed 75 and 76 ik at start
of stady, observed next ** ik
e) 3 enployaed 188-266 ik st start of
stady, observed neit 36 sk
Blood Cd Increased to 120 days then
Oclne Cd ap daring 0-15 days of
axposare. sore sloily 15-120 days,
rapidly after 120 days
Iddltioaal data on exposure levels
and kidney faactloa.
Eaployees, 2*-*7 yr old, working with
CdO and Cd salt. 2/« nev esrloyees
aad */7 old employees saoked >19
cigarettes/day.
Icrkers vith longest deration of
siposare shoved kidney disterbaacea.
anus; CIDBIOBI BRIL poxsonio;
HOOD; OBXBCi OCC0P1TIOII1 HK110S;
IIDOStllll ITHOSPBBBBS; XBDUiTBXil
BMIBEBl COBFlBITXtB BTUOaTIOBSt
BIOlCCOBOLITIOIt RBTIBOIXSB; SSOKIIO;
BIIOXOB
•1 Sabjects fros Chicago, 197*
b) Sabjects fros Chicago, 1976
c) Sabjects free Dallas, all ssls
10IPOSB IXSSOIi BLOODS CIOBZDB: Bill I
XXLXBOXS; KXDBBTS; HTBlj B09CUS;
EllCIIISt HSU; OBin
a) Penalea in 8 groaps ilthin range
of sedlaas given
b| Bales in 7 groaps within range of
eedlans given
111 inhabitants over 20 yr in 9
haslets la heavily Collated river
area ia Japan.
frevaleace rates of orlaary total
crotsla plis glacose,
Eetalsab) 2-slcroglebalin,
retinol-bindiag pratela, and proline
all Increased with increasing erlnary
Cd.
BXOIBDXCanBSl CID8IOHI XBDOaiBXal
(ClIATXOIi JIMBl IIDItTS; BRaUl
1 MOTBXBSI OBXn
BEHBEICE
laaierys, B.
Boels, B.
Begniers, B.
Bachet, J.P.
Beraard, 1.
Goret, 1.
1979
(oval, B.B.
Johnson, D.B.
Kraeaar, D.P.
Pahren, B.B.
1979
Bogaoa, K.
Kobayasal, B.
Bonds. B.
1979
ro
-------
Cadalaa
7MO-43-9
ItB 112.40. If 321 C, If 765 C. *I 1 •• 8g »t 39* C, 10 •• flg at «B6 C
(conxnio)
TCSSIB
1891
Ociaa
1892
Oclae
1893
Drill*
Bxroson ram
lagestloa
1BUTTICU.
BBTBOD
us
....
us
us
BOBBBB
or CUBS
9
al 38
b| «8
IS
UlflB
a| Bot glvaa
b) Bot given
c) Bot glvan
a| Bot glvan
b) Bot glvan
0.16-1.65 ag/al
a) 15.8 » or - 1.6
ag/day
b) U.3 * oc - 0.7
ag/day
c) 10.8 * oc - 0.03
ag/day
*
a) 0.07 aaoles/1
b) 0.05 eaolea/1
O.S« ag/al
8BBBB1K XBFOBUnOB
a) B stadias, 21 days each- 32 ag Cd
plas 200 eg Ca/day
b) « stadias. 2« days each- a* og cd
plas 800 ag Ca/day
c) 1 stady, 18 days- 35 ag Cd plas
1500 ag U/day
Baaa » or - S.B.
1 stady egalvalaat of 1 case
Balaace and other data available.
7 patients alth psychonenrosla. 1
•1th kyperealdaraa, aad 1 »lth
Pigat'a disease, «1-63 yc old. all
la good physical condition.
amis; TBkCB BLBBBB1S; BXBBULS:
CMBXHB; COHBBi BaBQaBBSB; IXBC;
CCBMBKXVB ITllOHIOBSi rtCtSl
OKIE; (DOLTS; DXBSS; BBTlBOlXSBl
XILXBOIS
a| cacdlotaacalar patients
b) loraotanslv* patients
levels axtreaely variable vlthln
patients.
Patients alth aodecate to severe
cacdlac conditions aad/oc
hypertension. Controls alth BO knova
cacdlovaacalac syactoas. Ill ovec 30
yc old.
BltUS; C1DBXOB; LIU; CaBDICvkSCOUl
DISUSES; OBXTBD BXBODOBt
IICEITEISIOI: tGEi IDD1TS; SCOnH;
CCRPlllTIfE BtllOMIOBSi BLOOD; OBIBB
lc apparent dlffecences la relation
to tlae, aei, oc age.
Onexposed volaateecs. ages 20-5* yc.
BMUS; CIDBXOB; LUD; ORIIB;
BIISOBBBBBI BBTBODS; I6B; SBI;
COBFIBtTZfB BTtUitlOBSi BBB TOK
BBFBBBCB
Spencer, B.
isaassea. c.B.
BoltHea. B.B.
Kcaaec, 1.
1979
Bheca, I.B..
ilbberley. D.e.
BdlBCds. K.B.
BaldcoB. B.l.
1980
Legotte, P. a.
Bosa, B.C.
sattoa, D.c.
19BO
-------
CaftaUa (8 CX)
18-Parla«-2.6-dlona, 3.7-41hydro-1.3,7-trlB«thyl- (9 CX)
£8-08-2
CB-B10-B8-02
88 198.19. Bt 236 C
TISSOS
189«
Blood.
fatal
1895
Blood.
plaaaa
1896
Blood,
plaaaa
1897
Blood,
••Til
BIMSOU BOOT!
iBgaatlOB
Xngaatlon
HILTTXCIL
HBtHOD
HPLC
0»
HS
BPI.C
or
BS
_
oc
BHC
1DBBBB
OF CUBS
99
_ _..
•) «
bl 6
c) 6
d) »
37
13
SIEGE
or - 2. 1 ag/Bl
c) 1.0 » or - 1.0
•«/•!
d) 1.0 » or - 1.8
«9/Bl
OEIlBlt IIFOBBHIOI
lomr limit of d«t«ctlOB 0.5 ig/1.
Dlatrlbatlan b««»ily sk**«d toiard
lonr or - 0.5 tg/l
1 (i»iatar« inCaot*. gwtatlcnal «gw
26-33 ilk, tCMtod «ltb th«opkyllln«
for apn«a. 1 adult*. aj«« 20-25 yr.
FBtlCS; ClltCI; TBEOPHILLIIBE; DBOOS;
0106 TBEB1PT; IlltRS; IDOLIS; BlOOOl
BICOD PUSBt; COIP1BHXVB
BtlMiTIOlS: LOIQS; BET1BO1IIE3;
BIIBOBB: IBOBOBOSCOtU DISB1SBS;
CIFFEIBE; OBBZlXCtl COBD
a) Mfor* tc«BtB*at
t» Man poaki attar 2.8-8.* ag/kg/dar
foe avarago oC 103.1 he, 25 can*
c) Day* 0-5, 12 control* fad ha Ban
ailk
Blgaoc is latoxicatad Infant*.
37 infanta «Uh apcaa, bora bafora 37
•k gaatatlon.
lozlcltr dxalopad IB 12: taAycardla
12), rogBEgltatloB or 81 bloadlag
(9), coaTBlaloBi (2)
THOPBTtLXIIS; DBOUt OEDO TfBEaPT;
XIHBfS: FB11CB! BIOOD VL1S91;
COBPttlTXfB mlOaTXOBS; SEtlBOlItESl
IBIBOlll EEOEOBOSC01IB DXSBtSBS;
C1FFEXIE
i) In fait a, < 30 *k oaatatiOBal ago.
cattaln* 10 ag/kg/day
b| Infanta, 30-33 «k gaatatlCBal aga.
caCfalaa 10 ag/kg/dar
c| Infanta, < 30 »k gaatatloaal aga.
taaopkrlliaa 2 ig/kg/dar
dl Infanta, 30-33 ak gcatatlcaal aga.
tbaopkylllna 2 ag/kg/day
XBtaceoBvacaioB aa Back a* 100*.
Infanta eaeaiviag aatayliaatkla*
tbarapy (or apaaa. lalgkt < 2.000 g
•has bora at < 33 aka g*at*tion.
xirtitsi BE BOS; BIOS taiuvit BIOOD
StEOB; IL1I10IS; COBMUtin
tfkioitioist uies; BBTUOLXIBS:
BEIBOIBi IBOBOBOSC01U DXSUSBSt
TBEOPEILIIIES; CUFBXBI
EBFEBEECE
Bory, c.
Baltaaaat, P.
Forth* alt, n.
Bathaaod, 8.
Fndarleh, 1.
traada, J.f.
1979
Bory. C.
Baltaant, F.
Vorthaalt, 8.
Bataaaod, 8.
Fcadarlcb, I.
traada. J.T.
1979
_..
Bontroy, l.j.
T«rt, P.
Eoyar. B.J.
BoolB. F.
loyar-Boccot. B.J.
1979
Bada, B.S.
naaaa, I.I.
Soaaal. 5.B.
TlB, I.I.
1979
(IBR PISE)
-------
St-08-2
C8-B10-14-02
II m.W. » 238 C
. 3.7-«lkjato-1.3.7-tri«»tkjl- I*
(CORIialD)
'n'^a,
1898
B1U
inoson Man
miracg
BXTBOD
me
OF CIS IS
28
UIBI
or • 0.5
mg/l.
28 rmadoi •••;!••
FIIICB; ClltDl; TBBOPBTUIBB5I DBOOS;
CIDS TBBBIPT) UPltlS; 4D01TS! BLOOD!
BIOOD PUSH] COBP1BHXYI
1TUOUIOBS; UNSt BBltBOlinSl
IIIB01I; IBDIOHDSCOL11 DXSB15BS:
ctHBini DBEH,X«L coio
uraniCB
BOIT. c.
Biltunt, p.
Porthailt, 8.
BMhraoa. B.
Vnteich. a.
»rand». J.T.
1979
-------
Calclna
7MO-70-2
Ca
Itl «0.08. It 850 C. BP 1»»0 C, TP 10 M «t 983 C
tISSOB
1899
kdlpoaa
1900
lorta
1901
Blood
1902
Blood.
BIPOSOIB BOOTS
IBkLTTXChL
RBTROD
X-ray apactroa
X-ray spectroa
•
.
US
IOBB8I
or CISBS
*
9
-TIZLUJLUrJ
•
72
39
IklOB
lot gi»en
lot gl»an
a) lot gi»an
b) lot gi»*B
c) lot gl**n
d| lot gi»«n
•t lot glroa
f) lot glTen
8. k ag/dl - aoraal
(HIT
HBkl
60.3 ppa dry «t
«866 ppa dry nt
a) 8.06 ag/100 al
b) 9.02 ag/100 al
c) 8.99 ag/100 al
d) 9. S3 ag/100 Bl
*| 10.2* ag/100 Bl
f) 10.26 ag/100 B!
_
lot glfm
P10I)
OBIIBIL IIPOIR1TXOI
Itdoaloal fat. 2 laaplaa take* par
cam. 2 anilyma on aach eaipl*.
197« aatopalaa of 10 Piaa Indians, a
Papago and a Cra«k Indian.
(OTlSSIOR; CUCIURi IIOIj COtPBI;
tXIC; IOBXDIOI; IICIBI; IBID; RITklS:
lliCB BLIHBBtS; LIfBI; SPLBBI; IOBTI:
HOISTS; 1DIPOSB TISSUE; PlICBBtS;
BflSOBtaiK BHBOD3) kOTOPSIU
2 aaaplaa pac case. 2 analyaaa OB
aach aaanla.
197« aatopaiaa of 10 Piaa Indiana, a
Papago, and a Craak Indian.
(OTISSXOR; CIICIOR; HOI; COIPBI;
SIIC; BOftlDIOB; IXCKBL: IBID; RBTalS;
tlkCB SlIBBBfSi Ltfll; SPLSBI; MBTi;
IXOIBTS; ID1FOSB flSSOB; PkldlkS;
BilSOIERin 8BTHOD3; iOTOPSIU
_
•) Blood froa 22 acthara, loa birth
•t groap (1500-2500 g)
Bl Blood froa 50 aothara, noiaal
birth "t groap (>2SOO g)
c) Blood froa 22 aothara, notaal
birth «t groip Batched aith ]o« birth
at groap foe aax, aatcrnal aga. raca,
•Boklag kabita, (arlty
d) Cord blood froB 22 aothari. low
birth at groap
•1 Cord blood froB SO aothari, aoraal
birth at groap
f) cord blood froa 22 aothara, nocaal
birth at groap latched with low birth
at groap for MX. aatamal aga, race,
aaoklag kablu, (arlty
gcthara aho gar* birth IB lanrk, u.
tprll-saptaabar, 1975.
BRUSi CkLCXOBl CBBOBXOBi CCPPBI;
1 101; RIQIBSIOB; IXICi BIOOO| IDOUS;
PROS! IBI JBISBI: COBNIktin
BfklOMXOH
lerial ranga 8.9-10.5 ag/dl.
Bypocaloaala IB « of 39 patlaBta.
Idllt apllaptio patlanta attatdlng
aaarology oatpatiant cllalca of
toroato a«Mtal and Toronto Baatara
Boapitala. 23 MB aid 16 woaan. Bean
am 45 yr (rang* 26-72 yrl .
pragMBt abnoraalltlac of calolaa and
bcaa aatabollaa.
CIICXOII RBTlBOLISI; CBBHOTBniFt;
(BOSPROIIS; nxIBBS;
alDtOXTCBOLKkLCXPUOLSl BIO OB SBIOHl
ClltlU IIITOOS ST5TBI DISBISBSl
IIIBI1LS; CllkOk
r
IBPBBIICI
RangalaoB, I. P.
Rill, R.I.
llalaoB, K.K.
Batovgh, D. J.
ChrlBtOBMB. J.J.
Xxatt. I.R.
Blcharda, D.O.
1979
Raagaloon. l.P.
Bill, R.I.
lialaon, K.K.
Batoagk, D.J.
Chcl«tana«n, J.J.
Xxatt. I.B.
licharda, D.O.
1979
Bogdaa. J.D.
Thind, x.S.
Kaap, P.f.
Cataclnl, I.
1978
pylypchak. a.
OroopoBlo*, D. 8.
lllaon, D.I.
Rarrlaon, J.I.
Bclalll. K.e.
Baaaa, H.I.
OgllTla, I.
startridga. i.e.
lirrmy. T.B.
1978
-------
CalCl«B
7MO-70-2
Cl
Itf «0.08, HP 850 C. B» 1««0 C. f» 10 n «t 983 C
TXUOI
1903
81004,
•eraa
190«
Bloat,
•KM
1905
B1004,
MEM
1906
Blood.
••cm
BirosBU toon
ingeatioa
tnimcii
BBTIOB
us
.
us
BOBBBI
or CISBS
1B7
•1 *
b) 3
•I 16
b> 18
c) 32
•1 16
b) 16
c| 9
UIOI
•I Bat give*
b| Bet gl»en
a) 9.2-10.0 ig/11
b) 1.0-6.8 ng/41
a) lot gl»en
b) lot given
c) Bot given
a) 9.71-9.57 ag/11
b) B. 50-8. 76 ig/11
e| 9.01-9.41 *9/«l
(BBR
BBIB
al 11.2 eg/100 il
bl 11.0 Bg/lOO •!
•1 9.7 ag/dl
b) S.« ag/ai
-
•I 9.0 ng/dl
b| 9.8 19/11
c) 10.0 19/11
•1 Bot applicable
bl Bot applicable
el Bot applicable
PACB1
0.BBIB1L IBfOMUIOB
•1 Ben
b| Bonen
Criteria (oc lov levels < 8. 4 Bg/100
• 1.
Bnal OtakBI, 56 MO, 129 «OMD, lean
age 69 fr.
DIETS; TB1CB BLBBBBTS; CBOLBiTBBOLS;
HOOD SBBDB; UBC: COPfBB; POTMSZOB;
SCDXDBs B10BBSIOB; CUCCTB; HOB:
flllHIl k; TR1BIIS
l| coatcola
b| Patleota ilth hypopacatbrcolUn
ciicioi; iBosvaons: BBTUS;
BItlBOUTBSl BLOOD SBBOa; OBHB;
BTDIOITCBOlICalCirBIOtS; TIT IB IB D;
OIITBD KIBODOR
a) Control! (vltaala D leflclent)
b| 3000 unit* of fltaaln D2 1»
capaules eeeklf for * »o
c) Tltaila-D-foEtitlel float foe 6 ao
Ulan* In 61a*gov, 20 adult* anl «6
cklllcea fcoi U faaillw.
Sena aablect* hal bloeheilcal
abnoraalitlea Mggestlve of ticket*
ot oateoaalacla.
CIICIOB; BET US I B1OOD SBBOBJ TRtBIB
E) »SI»; OBITBB IXBGDOB; BDTKTIOBit
DiriCIIBCIBS; DIBTSj CORPaBlIITB
itUQitioBS; viTians
a) Control, 0 and 6 he aftec 50 mg in
b) cltckotici, 0 and « hr after 50 a?
In
c| Poataacglcal groip, 0 and 6 at
attec SO ng In
111 gtoapi fasted before In.
1C contcola, 16 patients vlth
alcoholic clcchoaia, 9 mtgical
patient* «lth lelayed healing.
UK; CIRRHOSIS; OBIBB; BIOOC;
BfBBtSU; BIST TZBGIUt; SOKBBI;
CIICXOH: B1GBBSXOB; COPPBB; UaCB
HIBBBTSl DBDOS; UmiS] IITH;
DISBtSBS
Biraincv
riahet, s.
Bendticka, D.6.
Hahoney, ».i.
1978
Raver, B.B.
DaTlea. B.
Backhooae, J.
BUI. L.P.
Tarloc. C.R.
1976
Piettek, J.
Undo, J.
Pteeee. R.i.
O'Blotlan. J.L.B.
1976
Sullivan. J.F.
Jetton, R.B.
Buck, B.B.
1979
-------
Calcloa
7MO-70-2
Ca
Itf »0.08, at 850 C. BP 1B«0 C. fP 10 » «t 983 C
(COITIIOBD)
txssoi
1907
Blood.
••EBB
1908
Blood.
••CBB
1909
Bale
1910
UdMV
BXPOSOtB BOOTB
Ing* at ion
iBJaetlOn
illLTTIClt
BBTBOD
US
us
kkS
X-ray apcctroa
IOBBBI
or CISBS
1
"
2«
8
12
met
a) 7.5-8.2 ag/100 al
b) 6.8-8.1 ag/100 Bl
c) 8.8-8.6 ag/100 al
«) lot gt»«n
b) lot giT*n
c) lot gi*«B
d) lot gl»*B
•) lot gl»an
a) lot gl»*n
b) lot git*a
c| lot glvan
dl lot gi»*n
•) lot gt*«a
a) lot gl«*n
b) lot giT«a
(IBXT
Bill
a) 7.85 ag/100 al
bl lot gi»an
c) lot glTaa
a) 9.9 Bg/100 Bl
b) 10.0 Bg/100 al
e) 9.1 ag/100 al
d) 9.6 ag/100 al
•) 9.3 ag/100 al
a) 761 ppa
b) 392 pp*
e) *32 ppa
d) 1151 ppa
•1 1953 ppa
a} 937 ppa dry at
b) 1363 ppa dry at
flOll
GZBII1L IIPOBBJTIOI
•) it (daiaalon fox oat«oporcal»
b) Daring 1 to 10 nk of oral tltaaln
C2, Ca I P0» therapy (dally do**a
1000 10, 0.3 9. 1.76 g.
raapactiTily) . Prograuif •
daainartlliition
e| 5 to 12 ao aft«r third ca infaaion
(total ia.7 g Ca| daring aalatvnanc*
OB oral therapy •• in b| . »lckat»
aad oat*oporoaia aba*nt.
Kaaag* (•••!• «itk apiatic
gaadriplagla. iaaobllis*d frea
iafaacy.
If Ca r*ll*T*d ayaptoaa of
•aticoBTalaant-r*lata4 clckat> and
OBt*oporo«ia. Oral Ca. rltaala D,
•ad P0» lB*ft*ctlt*.
If Ca proaotad raaiaaraliiatioa of
bcaaa and radoc*d aria* P0». oral
Ca. Tltaain D, aad H* ln*ffactlT*.
CIICIOB; BIBZI1L BR1BOLISB;
imCOIfOtSMTS; MIISTlfllllj OBXIB:
61000 SBBOB; OISB1SBS: TIT1BH 0:
BOIBOIBSi DBOB TBBI1PT; BOBI
DISIISBS; PBOSPB01B3! C1SB IISTOBXBS
a| a-6 10 lactatioa
b) 7-9 BO lactation
c) 10-15 ao lactation
d) 16-21 BO lactation
•1 22-31 BO lactation
Iklt* >oaan. 2-31 ao poatpartna.
BLOOD SIBOI; Bill! B1IB; BIT US;
lICtlTIOB: ClICIOB; UOIBSXOI;
BIM1KSB; 1MB! CCPtBB; XXIC
a) 1-6 ao lactatioa
b| 7-9 BO lactation
c| 10-15 BO lactation
d| 16-21 ao lactation
•I 22-31 ao lactation
•kit* «OB*n. 1-31 BO poatpartaa.
11000 SHOBI HlBt IkXBl BBTUS;
IICTITIOI) ClKXOBl BIQIISIOI)
BIB01IBSBI ItOBl CCPfXI) IXIC
a) Mdall*
b| Cortel
2 aaapl*B par caaa. 2 aaalyaaa OB
•aeb aaapla.
197* aatopalw of 10 plaa ladlaaa, a
lapago, and a Cr**k Indian.
lOtkSSXOBl CIICIOB | XBOIt COtTBII
tXBC; tOBIDIOBI IXCKILl 1UD; BRILSI
tBicB niBiRSi iifBit snail! 101*11
BIDinS; IDIP03B TISSOIl PlldUS:
BtlsniBIBT BBTBODS; IVTOPSItS
IBFBBEICt
Latorr*. B.
K*nny, T.a.
197*
Tanghan, t.l.
«*b*r, C.I.
I*ab*rling, s.B.
1979
faagkaB. 1.1.
B*b*r, C.I.
I*ab*rllng, S.I.
1979
Baag*laon, l.r.
Bill. B.I.
Ilalnn. I.K.
Batoagk. o.J.
Ckrlatauaa. J.J.
laatt. I.I.
llckarda, D.o.
1979
00
-------
CBleiu
7MO-70-2
Ct
It! 40.08. II 850 C, Bt 1MO c, n 10 n at 983 C
(conxioiD)
nsaaa
1911
.
1912
11 Tar
1913
Urar
191*
Bilk
luoaan BOOM
•Bunzcu
BBTIOD
IS
X-ray apactcoi
BS
US
IUIBBI
OP CaSSS
a) 13*
b) 73
0) 86
10
a) 91
b) ••
e| 72
•) 28
b) 39
c) 23
d| 13
a) 28
f) 30
tun
al lot giTaa
b) lot givan
e) lot glT«
lot gl»an
a) lot gl»an
b) lot glTan
c| lot glran
a) lot gi*an
b) lot gl»«n
c) lot gl-an
d| lot gUan
a) lot glian
f) lot gl-an
(BEIT
Bill
•I 515 ppa
b) 625 ppa
c) 653 ppa
199 ppa dry *t
. _ _
a) 216 ppa
b) 232 ppa
e) 277 ppa
a) 257 « or - 29
ng/al
b) 236 » or - 25
tg/Bl
c| 175 « or - 28
ag/Bl
d) 170 » or - 25
ag/Bl
a) 196 » at - 30
ag/al
1} 150 » or - 38
ag/al
HOB)
QBIIBBl XIPOBBITXOI
•1 lo ranal diaaaaa
b| Icata ratal dlaaaaaa
e| ckconlc canal dlaaaaaa
a) dlffacant fro* bl and c) , p<0.01
Valaaa aca dry at baaia.
litopalaa at OCta Boapital.
TIKI UIBIR3I IBTUS] iOtOfSXISl
ciLiroiiias (XDiByat IXTBII SPUBB<
BiaUaiS; HtfBlIBISIOBl SODXOBt
fOTiaaXaa; CMCXOIl nOaPBOIOSi
BianaxaBs CIDBIOB; incj COIPBII
IIIDI XIOB; UBS1BISB: UOBXIOBl
sniCOIt TITIIIDB; COBALT: BXCBHls
BOtYBDBIOI; Hi! CBBOBXBB; SHORI08:
BIBIOB; LXTBina; SXITBII T1BIDXOB;
BOIOI
2 aaaplaa par caaa. 2 ualyaaa on
aaeh aaipla.
197* aitopiiaa of 10 Plaa Indiana. •
Papago. and a Ccaak Indian.
fOTlSSXOB; CllCXOBs HOB; COPPSI;
SXIC; lOBIDIOB) BXCIBll LBaDi BRaLSl
TI1CB BLBBBBISI LITB1; SPtlBH IOIT1:
IIDIBTS; IDIPOSB TISSDB; PalCllkS;
BlaSOBBBIR BRBODS; 10TOPSIIS
a) lo ranal diaaaaa
t\ Icata tanal fallocaa
c| Ckronle canal fallaraa
•1 and e| dltfarant, P<0.01
Talaaa ara dry it baala.
latopalaa at OCla Boapital.
TBICB BlIBIITS; BJTUS; HOtOHXBS;
ClllVOIIIkl HDlBISt LITBBJ 5PIBBI;
DXSB1SBS; BIPBBTBISIOB; SODIDB;
tCTlSSIOl; CIKXDBl PBOSPBOIOSi
aaaiisxQBi ctoaxoBi uic; conn;
UaD| XIOI) BUOaKSB; UOBIIDB;
aniCOl; TITIITOB; COBUTi BICMli
BOLIBDBIOI: 1X1; CBBOBIOBJ SnORIOB;
BIBIOB; LITBIOB; SXITBI; TalUXOB;
BOIOI
i) 1-3 no lactation
b) »-6 ao lactation
c| 7-9 ao lactation
d| 10-12 no lactation
al 13-18 BO lactation
f) 19-31 no lactation
Ihita lonan, 19-«2 yc aga, 22
priaiparaa.
BIOOO SBIOB; Bill; BBTILS; IKTMIOI;
BUR; CI1CIDB; BaOIBSIOH; BtMIIEIB;
IICI; COPPII) ZIIC
BBFBIBBCI
iBdcapraait, s.
tlazandar, a.T.
Oonlck, B.C.
197*
Bnngalaon. I.F.
Bill. B.I.
lialaoa. K.K.
Batoagk, D.J.
Chclatanaan. J.J.
Itatt, B.B.
lichacda, D.O.
1979
Xndrapraalt. S.
tlaxandar, a.T.
Oonlck, I.e.
197*
Taagkan, l.l.
labar. C.I.
KaabarllBg. S.I.
1979
-------
CaleiBB
7MO-70-2
C«
atl BO.08. at 650 C. BP 1BBO C, TP 10 u *t 983 C
(COKIIOBD)
TISSUE
1915
tall
1916
Paaenaa
1917
SplMB
1918
SplMB
BXPOSOBB IOOTB
IHLTTXCIL
HBTBOD
Ik
X-ray spcetroa
X-ray Bpactro*
BS
•OH BE 8
OF CISSS
Bl 50
b| 50
c| 3»
d) 23
%
a
Bl 91
bl *0
c| 78
IklOB
a) lot glroB
b| lot gl»«n
c) lot glT«n
d) lot gi*«B
lot glTBB
lot gl»*n
B| lot 9lTBB
b| lot glTBB
c) lot glvm
BBII
a) 1336.2 ag/g dry »t
bl 986.7 ag/g dry it
c) 9*6. 1 B9/g dry it
d| 8*7.9 ag/g dry it
377 ppa dry it
-...
320 ppa dry «t
a) 2SO ppB
b) 320 PPB
c| 289 ppa
GEItllt XirOIBATXOI
a) Patkara
b| Botkcra
c) Bala taanagara
dj Paaala taanagara
tal«BB also glTBB for Mdiani and
gacBvtrle aaana.
50 Balanaalan faalllaa, BBBB ag« of
fathers, «6 yr, aotkara ai yr. «3
aala> eUldrBB, 12-2* yr and 38 taaala
cklldran. 12-2* yr.
CILCIDB; SODlOBl HadlBSXOB; ILOBTIOB;
SOIFOI; cnoiXIB; nilDSOB;
BHSklESB; COPPBI: TUCB BIBBBItSi
HOOD PltSSOIE; IB! GOIIBk; BBTUS;
mis
2 saapl«B par caa*. 2 analyaas OB
aack saapla.
Saaplaa froa 197* antopalaB cf 10
PlBB Indiana, a Papago, and a Craak
Indian.
COTASSIOB; CIICIOB; HOI: COIPBI;
tllC; 10BIDTOB; IICKB1: LB1D; BBTiLSi
1HCE ELBBEITS; IXTBI; SPIBII: MIT*;
IIDIBTSj tDItOSB TISSOBl PMCBBtS;
• USOIBIBIT BET BODS; 10TOPSIU
2 aaaplBB par caao. 2 analywa oa
aaeh aaapl*.
197* aatopalaa of 10 Plia Indiana, a
Papago, and a Cra*k Indian.
POUSSIOBj CIICIOB; IIOI; COtPBIt
tllC; 10BIDIOB; IICM1: LEkD; BRtLS;
tltCB BLSBIITSi LXTBIl SPllll) WlTi;
IIDIETS; 10XPOSB TXSSOB; P1BCBB1S;
IU50BBBBIT BBTBODS; IOXOPSXIS
B) lo »aal dlxvaaa
b) acat* ranal (allara*
c) ckranlc ranal fallana
a) and b) dlffatont, K0.05
TaliBB ara dry it baoia.
lotopalBB at OCll Boapltal.
IHCB ELEBEITS; IET1LS; lOTOPSXBSi
cttiroiiik: iiDiBis; ixraii sfinii
DISUSES! BTPSITBISXOI: SODIOBt
COTISSIOB; CIICIOB: tBOSPIOICSt
IIGIESIOa: CIDRXOBl tXICi COIPBBi
LIlOj IBOIj IkiatllSI; UOBIIOBi
SXIXCOli TITWIOB; COB I IT: IXCOL;
BOITBDBIOB; 1X1: CBIOHXOli SHOITIOBJ
BkllOB; tITBIOBt SXLTII; T1I1DI08I
BOBOI
IBPBIBICS
BBBlrOBl, 1.
KolrtyokaaB, S.I.
Place*, J.O.
Schaaachnla, B.C.
1976
Bangalaon, l.F.
8111, B.I.
llajUOB, K.I.
Batoagk, D.J.
CbrlatajBBBB, J.J.
liatt, 1.8.
llCBBtdl, 0.0.
1979
_
Bangalaon, l.p.
Bill, B.I.
llclson, I.I.
Batoaga, D.J.
Ckrlatanaan, J.J.
I»att, 8.8.
llcharda, D.o.
1979
IndrapraBlt, s.
klaxandor, «. f.
Ooalek. I.e.
197*
IO
o
-------
Calclaa
7MO-70-2
Ca
ItM 40.08. •* 850 C.
1MO C. Tt 10 u at 183 C
(CORZIOID)
TISSIB
1919
«Mtk
1920
Orlae
1921
Orlae
"
1922
Oriaa
...
•ifoson IOOTI
Ingaatlon
.
Ingaatlon
Injection
iiunicu
IRBOD
Badioaatcy
US
us
us
IOBBB1
0V CISB3
291 teeth
Bl «
b) 3
a) 16
bl 16
1
BIMB
a) lot giian
b| lot glTan
c| lot given
.
a| 55-707 ag/lar
b) 1*8-5*8 ag/dar
at «.8-2.« agAr
b| 3.«-3.8 agAr
al lot applicable
b) lot applicable
(HIT
mi
«) 36.71 of aak
b| 39. OX of aah
c| 3S.7* of ask
al 360 ag/day
b| 358 ag/day
al lot applicable
bl lot applicable
al SI ag/2* hr
b| 82 ag/2* hr
PIOB)
OIIIUL XlfOIBITXOI
b| 22-28 re
c) >3* re
fooled saaplea, average 7 teatk per
aaaple. Otkec data available.
Teeth fcoa people living la loaer
Silesia In soatkeeatera Poland.
SIlOITIOBt CILCXOBt CBSXOB;
POTISSIOB) BIDI0130TOPB3; BBUlSl
TIRIl POt I ID
a| Controla, 32-36 «k pregaant,
loaatieal diets
b) 32-36 «k pregnant, 1 g/day extra
calclaa
7 priaapacas, aged 16-19 yr
CILCXOB; BIOIISXOBl PBOSPHOBBS;
BltllSi OIXBIl PBBBIIICI; DXBSi
losnuxi; coBtiitixvB mtonxois
a| Control, 0 and 2* hr attec SO ag
In
b) clrrkotle, 0 and 2* kr after SO ag
la
111 fasted before (a.
Ccatrols. patients «ltk alcoholic
cicrhoaia.
IXICi CIIIBOSXS; 01IIJ; BLOOti
iinisui M» THOIHI; SOICBIT;
CltCXOBi BKBBSXOBt COPPBBs 1IICB
lIBBIRSt DlOeSt BRIISi LITO:
OISUSBS
---
a| it adalaalon tor osteopocesis
b) Daring 1 to 10 ak of ocal Tltaaln
02. Ca aad (0* therapy (dally dose
1000 ID. 0.3 g, 1.76 g,
raapectlv ely) . ProgreaalTa
deaineca Illation
cl S to 12 ao after third ca iatualon
(total 1*7 g cal daclag aaintananca
on ocal therapy as In b) . Blcketa
and oateopoioaia abaeat.
Teenage teaale aitk spastic
gaadriplagia, iaaoblllted fcca
lafancy.
IT ca relieved araitoaa of
•ntlcon>alaaat- related rickets and
eateoporoala. Ocal Ca, Titaaln D,
and P0» Ineffective.
II Ca proaoted realneralitation of
tones and cedaced arlne PO*. oral
Ca, Tltaain D, and Pol ineffective.
CltCXOBi BXIIBIL BniBOLXSB;
IBtXCOITOLSIRSl P1IHTLT1III; roilB;
BIOOD SB BOH: DXSBISIS; TXtlBH D:
BOIBOBBSj DBOO TBBIIPT; BOIB
DXSBISBS; P10SPHOIOS
UTIIBICB 1
eloaiak, B.J.
Pacyaa, J.
Palcxynaki. I.J.
1977
Oaggia, o.o.
Lynahaa, B.C.
Dale. B.I.
Evana. B.I.
Tiller, D.J.
197*
Salllvan, J.P.
Jetton. B.B.
Bnrck. I.B.
1979
latorce. B.
Keaar. V.I.
197*
-------
Calclaa
7MO-70-2
Ca
»ti «o.o«. at eso c. a? i««o c. TP 10 » at 983 c
TISSUB
1923
gels*
192*
OrlM
EIPOS01Z BOUTB
Ing* >t Ion
Hitmen.
RETROD
11
us
-
IOBBBB
op cists
1
12
BlfOB
110-242 ig/2* nr
•) lot given
b) lot gi»«
mil
na »g/2« he
•
•1 0.171 » OC - 0.016
9/diy
b) 0.1*9 » or - 0.01*
1/«»T
i
GBIIUL IIFOtUTIOl
__ .
Bialthy >al«, 3 »lpl«« o««r 2 «o
SITUS; IUCt B1EBBITS; HSJIIC;
BIOR1IB; CI1CZUR: CB10IIIBJ COBU.T;
CBBOBIOB; CBSIOl; CO??BI; RliCOIT:
IODIIS; rOTkSSIOI; RtiailBSB; SOOI01;
lOBXDIOHt SIUIIOB: XIK; OBI»t;
BIlSOIBRIIT IBTBODS
•1 ton flb«r diet plu 1.070 9 C*/d«r
let 26 d«T»
t>) Ugk £ib«c dl«t plM 1.16C g
C«/a«f tot 26 a«y»
IKln » or - SB
S»pl«« collected doting list 7 d«7B.
(•lane* data available.
31-58 »r old mn
HITILS) TllCt B1MBIT5I BIlBFtLS;
OIXBB; iDOLTS; PBCBSi CaLCXOt;
BISIBSIOi; XIOIj SltlCOl; COBPII1TXTE
(TUOUIOIS: DIBTS; riBBBS;
• IIUOUSRs BIITLtID
1EFEBEICB
Carnal la, I.
Spa*cka, t.
Boat*, J.
1975
Kalaar, J.L.
Banall, K.B.
Prataer. E.S.
1979
NJ
NS
-------
CtcbtBic «oW, Mthyl-, o-lMpcapexfthMrl nt« (8 Cl)
IkMOl. 2-(1-MtBTli*thoxT|-, MthylcubUBt* (9 CD
11*-2f-1
C11HI15-I-03
11 »».«. » »i.s c
nan
1925
Oclra
IBJOCU.OB
D«ra«l
imon
ttUoMtiy
•man
or CUB
c
»KI
•) lot glt«a
b) lot gl*m
•Ml
-
*| 83.11
b) 19.CS
Giimi xiroiitTiai
• 1 I* «OM Of 1 «Ct
b| Topical «dilBl»t£*tloB of 1-J «cl
r«cc*nt*9« oC do«* «icr«t«a In 120
he. Beta la t* oocrcetM tot
ticoBplat* cvconcT b«Ml OB 4*ta IB
•1
Iciltky *olait««r«.
(ISIlCIDISt BtlBICIDEIi
oiaiiopiosBiins: CHLOIIK ototnc
COBPOOIDS; aim;
imcRLoiacTaoBiiiH
imnici
Miauu, i.a.
BBlblch, B.I.
197*
CO
CO
-------
CaEbaalc acU. Mtkyl-. 1-nafktkyl astaE (8 ct)
1-laphthalanol. aatkrlcacbaaata |9 CI)
C3-2S-Z
C12-I11-I-02
81 201.72. flf US C
TISSQC
1926
Orlna
1927
dels*
EIPOSOBB tOOTB
IDjactloa
Dataal
IBILTTICH
Rinoo
Kadloaatcy
Plaocosoanca
apactcopkotoMtrr
BOBBIE
OP C1S8S
C
102
.
BUOE
at fot 9lT*n
b) lot gl»an
0.2-6S ppa
IBkl
a) 7.«I
b) 73.9*
8.9 ppa
GBIHH ZBPOBBATIOf
•) IT doa* of 1 oCi
b) Topical adalniatntlon of 1-5 aCl
PaEcantaga of doit «zcc«t«d IB 120
kc. D«ta la b) corcaetad foe
Incoaplata caeovac) baaad on data In
a).
laalthy folnntaara.
PISTICIDBS; HBBICIDBS;
oioiioFHOspams; CRIORIIB otsinc
CCHPOOIDS; OBUB;
nmcBioBocrcioatiii!
Slant «otkaca axpoiad to cacfcacyl.
Oaraal and laaplcatocy •zpoaora alao
aaaannd.
(ISTICIDBS; OBI IB; OCCOP1TIOUL
RltUDS
BirtBBICB
raldaann, B.J.
Balkaen. B.I.
197*
COME. S.I.
stalff, D.C.
Iraatronj, J. r.
•olf*. B.I.
1975
N>
-------
cirbuie Bcia, MtkTi-. 2.6-ivBUiB«airiUMtBri«M ««t«r {» CD
.C-fTCtUMUMthuol. bi*(MtkilcBrbBBBt*) (•«t«c) (9 CX»
• 253.25, BF 136-137 C
nsni
192S
B1004.
plBMB
Biiosm toots
XB9«lttOB
tllLTTICtL
IRROD
SPIC
•nan
or cisis
._
"
10
-
UNB
9,7-19.7 Bg/Bl
mi
11.5 «g/Bl
CBIIU1 IIFORMTIOI
F«Bk f*l(«B B(t«c *K2SO-Bg tBblvta.
MBk Bt 2.00 » or - 0.29 kr.
•OBOBIpOBCBtlBl •llllMtlOB. THO
(OCBlUtlOBI OMd dU BOt diff*C.
Rltltky BBl«*. 25-35 ft of BOB. doB«d
1 BC ««« liftld BMBkCBat.
DIMS; FIHCEl BIOOD FUSUi kDOMSi
CCRFI1*TX*E miOMIOflS
nranici
SBuarfl, J.
1979
to
Oi
-------
Ctrbulllc «cl4, •-ckloro-. Uoproprl ut«c (S CI)
Ctrbailc «ci4. (3-cklotoph*»il)-, 1-«»thyl»tkyl Mt
101-Z1-3
C10-B1Z-C1-I-02
II 213.6«
fl* «0.7-«1.1 C, BP 1»9 C «t 2 » Hg
(9 CI)
man
1929
Bloofl
BXVOSOII BOOTS
1IUTTICILL
RBTBOD
OC
0
•1
b)
IDHBB1
OF CUBS
•1 6
b) «9T
UBOB
•) 7-«0 ppb
b) lot girm
SEtl
...
•) 18 ppb
b) < 1 ppb
OBBH11 IBFOBBtTIOl
__
Siipl«« iii ihleh CIPC ••« poiitivclr
IdntlCUd
b) 111 »ipl«*
*o«Uoct«H, TlcglBl* SUt« B*die«l
I»«ln«c« Ofttc*. 1972. Iboot «S(
ftoi «klt« ••!••, 30% fro* black
»lu. 15X ttot «hit« f«Hl««, 10X
(to* black C*Hlu.
CBWBXIB oiainc COIPODBDS; IDT; DDE:
OIUDIIl! flBOIIIl: UOODi
(ISflCIDBSt POirCBlOMHTBD
HPRBBnSi HIUCBLOBOCICLOBIUIB:
BIPTUBtOB BHXIDIi CBIOBIB1IBD
BIOBOCIBBOBS
IBTBRBICB
GrlCflth. P.O.. Jr.
Bltok*, B.T.
1975
to
-------
CMbOlfllMIOglObiB
IOC1-29-1
•net conosraoi nnoii 01 OBMTBBBXBBD
nssiB
1930
Blood
itrosm Boon
XikiUtloa
IBUTTICU
nnoD
Of
•UIBBB
OP CM IS
10
B1BOI
•) Bat Jl»»n
b) lot glra
c) Bat gl»«n
•BIB
•} 6.3IS
b) 6.251
0) 3. MX
QEBIUt IBIOBBkTIOB
-
•) SMkl>9 elgarattai «tth JfO 19
CO p«r elg«r«tt«
b| Sioklag elganttu >tth 1C. 97 ig
CO per elgcntt*
e| Sioktng clgu«ttM «ltk 7.99 ig CO
F«t eigmntt*.
BIWMLOBZBSl BtOOD; OBHBO (IB8DOI;
SBOKIMl C1IBOB IBOB81BXC COITOOBDS
BxtfABkCK
Turner. J.k. BOB.
Stllctt, B.B.
Btll, C.P.
197*
10
•vl
-------
C*tUl
•?»»
c«
1*0.12. » in c
TISSDB
1931
Rale
-
BXMSOBB IOOTB
-
»»»LTTIC»L
RETROD
._ _
n
IOHBEI
OF C1SBS
11
- - -
BIBOC
let tet«ctabl«-0.«1 ppa
-
•Ell
0. 1C ft*
GEIEB1L IIFOBBHIOI
.
Scalp kait
Conor* fcoi 1 TUlagw of lalk*
XoAlau IB tk* luiona* T«rrltoci««
ot T«n«sa«la.
Bill; fBlllOZUl BBTkLS; TltCE
EIEBEITS; SODI01; UOBIIOB; SILK01;
CBL01IIB: POTUSIOBi SCaBDIOl;
TmiZDBi UBIDIOB; CRIOBIOR] SOLD;
BIIOtlESB; IIOIj COBILT; BICRL;
CCPPSli (IBC; USBIIC; SEIEIIOI);
BBOUBBl SDtlDIOB; STBOBTIOI; SH.TEB;
IITI50IT; ZODIIB] CBSIDB; Bltlim;
IIBTSIIDS; CIBIOBi S1BUIOB; BBBCOIT
nrEBEicE
(••rkoni, 4.K.
Tclandia. J.t.
Di«n«», B.
1977
oo
-------
Caalaa
7MO-M-2
U
Itt 132.905*. ir 28.5 C. Bt 105 C, TP 1 aa lg at 27* c. 10 •• Rg at 373 C
TXSSM
1932
•air
1933
OEiM
•nosou toon
iMinxcki
•moB
n
»
ROIBBI
or CUB
11
a) 1
b» 1
IIMI
lot aatactabia-i.18 ppa
a) 6.7-9.9 «g/2« he
b) 10.a-i2.« ig/2* bi
nu
0.38 ft*
a) 8.4 agV2* br
b) 11. • «g/2* kr
smut iiroiunoi
Scalp kalr
Canon Ccai 2 Tillaga of Mlka
Indiana la tk« taaioua Tacrttorlaa
of Taaasicla.
mi: vniioiuj IRUS: TMCB
itinnst souoii uvinmi snicoij
CB101IM; fOTMSIOIS SCUDX01]
iitiiioit fiuDioi; cnoiioii ooioi
IIIB1IB3B; ItOIj COIUTl IlCnil
COttll; IIICj USIIXC) SBL8IIOII
BIOUIB: ineiDioR: snoiTxmi SXLTBI;
IITtaolT; IODIII; ClSIOl; BlUDSj
nininii ciixoR] lutBioi: RBBCOIT
a| laaltky ••!•. 6 aaaploa owe 9 ao
t( Maltky t«aal«, 2 ataplca 10 ao
apart
UAltloaal data ataUaU*.
BI1U.3; TIIC1 BLNBtTSi 1ISBHCI
BIOKIB; CILCini) CH01IIB; COBUt;
CBIORXDIl CBSXOBl COPPII; RBfCOKl
IODXIB; POHSSIOB; RIiatlBSB; SODIOR;
IOBIDIUR; SBIBIXOB; II 1C: OIXIBs
BB1SDIBSBIT HBTRODS
nniBicB
V*rkoB«. l.K.
Talaadia. J.».
DUaaa. a.
1977
Coraalla. 1.
Spaacka. a.
Hoata. J.
1975
Is)
VO
-------
C»Ui. Uotop* of aa>« 131
100*5-97-3
Cl
Itl 117. HP 28. S C, IP 70S C. TP 1 .1 89 4t 279 C. 10 II 89 «t 3">3 C
TISSUE
193*
TMtk
BTPOSOBE IOOTE
1I1LTTICU
BBTBOD
Badloactry
.
IOBBBB
OP CiSBS
291 t««th
UfGE
a) lot glf«n
b) lot gi»«n
c| lot ijl»«n
_
HEtl
•I 0.093 pCl/9 ash
b) O.OS3 pCi/9 ««h
e) 0.023 pci/q ash
GBIIIIL IIPOIMTIO*
a) Mcidaoai
b) 22-28 jc
c| >3» yr
Poolad •••;!•*, »«»<)• 7 t««th p«c
»ipl«. Otb«r data available.
Taotb fcoi F«opl« living In IOMC
Silaala in *oathn*«t*cn Poland
SlIOITIOa; CIKIOH; CtSlOB;
COTISSIOB; ItOIOXSOTOPIS; 1BULS;
TIITH; POltlC
BBPEBEICB
clovlak, B.J.
Pacyaa, J.
Palc*rn«kl, B.J.
1977
-------
CklordiM
12719-03-6
C10-B*-C18
II »09.8. BI 175 C «t 2 •• BJ, It 1110(1-5) » I» «t 25 C
nasn
1935
Blool.
MTU
Bnosni MOTB
iniTncu
BBTBOD
OC-BC
IOBBBB
or CISBS
6
BIB8B
60-233 ppb
BBIB
151 ppb
QIIIUL XlfOBBinOB
••la. ko«Mbol4B »ith OM or ion
i«ib*r« ta ptiticlte lidaitrj
laiMkalfl 4««t !«•!• 2.15-135.78
FF»'
BMlAxt* of I«14 coutr> CO.
tISTICIDBS; OR; DDI; LIID1I1;
RimcnoB iroxiDB: CBLOBIBB oiauic
COBPOQIDS; DXHDBXI; BLOOD SltDB;
CC101IDO; Oast; BIZlCBIABOCtaolBXlBB
nrainci i
Starr, H.8.. Jr.
lldrlch, r.o.
BcDO«9*ll. 1.0.
Bone*, t.B.
197»
-------
ChlorlM
77S2-SO-S
Cl
Itl 35.753. 8? -101 C, BP -3«.05 C, Tt «800 aa Bg it 20 C. 1 aa Bg it -123 C
TISSDB
1936
B«lr
1937
1*11
1938
Orina
EIPOSOIB SOOTB
lULTTXClL
BR180D
II
,
•1
It
IOBBEI
OP CIS IS
11
a) SO
b| 50
e| 3*
41 23
•1 1
b) 1
BtlGE
17.6-26.8 ppa
•) lot glTen
b) lot given
c) lot given
4) lot given
•1 3.»1-11.1 g/2» hr
b) 2.91-3.80 g/2« kr
Bill
21.8 pp»
a) 585.0 ig/g dry «t
b) 633.5 Bj/g ACT «t
c) 576.8 «g/g icy nt
d) 921.7 ng/g dry «t
t) 6.1* g/2» hr
b) 3.36 g/2« he
f
6BIII1L IBF01B1IIOI
Seilp kale
Donor* froi 2 Tillages of lalka
IglUu In tk« liatona* T«rrltorl««
at T«n«»«la.
8111; VMZZOEU; IRILS; T11CJ
EIBURS; SODIOR; UOHIIUHt SJ1ICOI;
CB10IIIB; FOUSSX08: SC1IDZOI;
HtlllOB; TtltDIOB; CBIOHIOB) GOLD;
BIIS1IB3I; HOI; COB11T; licnii
CCfPBI; XIIC; 1ISBIXCS SBtBIIVHi
IIOBIIB; IOHDI08; STBOITXOIj SHTBI;
1ITIBOIT; IOOIIB; CI3IOB; BiROB;
IHTBIIOB: CIHIOBj S18UIOI; BBBCOBI
a) rattora
b) Both.rs
c) Ral« tMnagari
aj p«ial« t«*ug«r<
fall** also gl
-------
CkolMtwol (8 CI)
CkolMt-S-«i-3-ol
57-88-5
C27-BM-0
II 3SC.6*. n 148.5 C
CI)
(ukrdcou), BP 233 c at 0.5 u Rg. 360 C »t 760 •• Bg <«oi« d«coap)
US9H
1939
Blood,
MCTI
ixronu toon
iiunxcti
Bsnoo
CoLoriMtrr
mm
or c»sss
1B7
UNI
•I 200 ig/100 •!
b| 200-2*9 mg/100 •!
c) 250-299 ig/100 »1
4) > or " 300 19/100 «1
Hill
t| lot gl**a
b| lot gi*«a
o| lot given
4| lot gtm
SIIEUL innuTioi
•I 25< of ««D and 16* of «OI«B
b| 391 of ••• «nd 381 of «o««n
c| 2RI of ••• mid 321 of «o«»n
4| 31% of ••• «>d «6S of DO»«
Kcc*Bt«gM in b) ud c| «tiit«Md
fro* grtpk
Diitsj TIKI nmnsi CBOIBSHBOIS;
BIOOO SBlDBt KIC I COPPB1; fCTtSSIOR;
SODIOBj BlSIBSIOBl CUCIOB! HOIl
tlUIXI li fXHIXIS
nt.u.01
Flsk«c, S.
Budrick*. o.o.
BahoMT. i.l.
1978
CO
-------
Carolina
7MO-«7-3
Ct
at> 51.996, IP 1900 C. BP 2(12 c, TP 1 mi Bg «t 1616 C, 10 >• Bg at 16*0 C
TISSOI
19«0
Blood
19«1
BlOOd
19*2
Bair
19»3
Bair
gIPOSDIB IOOTI
1I1LTTIC1L
RBTBOD
its
its
,
It
BS
IDBBBB
or ctsis
72
20
11
-
a) 126
M 90
e| 71
BklGB
a) lot given
b) lot given
c) lot given
d) lot given
e) lot given
f) lot given
lot given
f.a-9.6 pp*
a) lot given
b) lot give*
c) lot given
(in*
RItl
a| O.B* og/100 al
bl 0.58 og/100 el
c) 0.51 09/100 ll
d) 0.88 og/100 al
*) 0.68 09/100 al
f) 0.69 09/100 al
2.9 » or - 1.7 (SB)
ng/*l
•.3 ppi
a) 0.52 eg/g
b) 0.15 og/g
c( 0.80 ag/g
Beoaetrlc aaani
PtOl)
CBItBIL IirOlltTXOB
a) Blood fEGi 22 aether*. lo« birth
•t group (1500-2500 g|
t| Blood fro* 50 aother*. noiaal
birth it group (>2500 g)
c) Blood froi 22 lather*, noraal
birth «t group latched ilth lo* birth
•t groop for MI, aaternal aga. race.
aaoklng habit*, parltr
d) cord blood fro* 22 aother*. lo«
tirth *t group
e| Cord blood froa 50 lothari, noraal
birth vt groop
f) CoEd blood fro* 22 aothera. nornal
birth vt group natched ilth lot birth
• t groap for MX. aaternal age, race.
•aoking habit*, parity.
Bother* iho gave birth in latark. IJ,
tBEil-Sopteaber, 1975.
BITtlS; CUCIOH; CRRORIOR; CCPPIt;
IlOlt RtOIBSXOR; IXIC; BLOOD J tDOlTS;
rnosi in JiESBT: CORPUITITB
IflLUlTIOIS
Beiidenta of pollatlon-free area in
Japan.
CnORIOR; BXOIIDXCHOBS; JIPII;
aiiiB: iitkts; six; tei
Scalp hair
Conor* fro* 2 village* of talk*
Indian* la the kaasona* Territorie*
of Venezuela.
Bill; VniSOBU; IITtLS; TltCB
IIIRBITS; SODXVR: UORXIOR: SX1XCOI;
CBLOIIIB; POTtSSIOB; SCtfDIOBj
IITIIIOB: TlltDIOB; CRlOalOR; GOLD:
BHOtlBSB; IIOI: COBILt! BXCDL;
CCIPBIi SXIC; tISEIXCl SBIBIIOH;
BIORint lOHDXOBi SnOITXOI; 3XLVE1;
tlTIROlI; IOOIIB; CI3IUB; BkHOli
lIBIHtlOBi CIIXORl SkRalXOHl RBKOIT
a) Long Xaland children
b) Qaeea* children
c| Bronx children
Correlation beteeen Cr and deat.
Idditloaal data.
Scalp hair, caaoaaiau la II, age* <1
to greater than 51 yr.
IITtLS; TIICI ILIBIITSl BkllOBi
IOIOII CtDIIDI; CRlORXaii COIPUi
ItOll LBkOl IXTIXOli RtiatlBIB)
RIBCOBTl IICML1 S1LBIIOH; StLVBIl
Til; UltDiail IIIC! Btlli t«Bj
1 COLTS; CHILDUli SIX) CORtklMXTI
IIILOtTIOISl DOSTj SOX1SI kll
toiLonoi; oiiti tuts i in nu
iiriiiicB
Bogden, J.D.
Thlnd, X.S.
Renp, r.l.
Caterini, B.
1978
Boniyaaa, a.
Totoriyaaa, n.
loiiyaaa, K.
1980
Perkon*. t.K.
Telandia, J.t.
Diene*. a.
1977
creaeon, J.p.
•inner*, T.I.
Bnagarner, J.I.
Pinkerton, C.
1975
I
-------
CkcoaiBB
7«W-»7-3
Cr t
IH 51.996. n 1900 C. B* 26*2 C. It 1 •• 89 at 1616 C, 10 •• Bg at WO C
(COKXmiB)
nssBB
19«»
Bale
;
19*5
Bale
19*6
Bale
19*7
iidnef
•nasvn IODTI
aBURXCIL
nnoD
us
us
BS
IOBBBI
OF CMBS
•1 26
b) 28
•1 31
b) 17
c) IB
d| 19
•1 12
O 10
1IIOE
•) 76-*73 ppb
b) 35-298 ppb
•1 fat giTan
b) Bat given
o) (ot given
a) Bat given
•) Bet given
f) lot given
•) lot given
b) lot given
c) lot given
(HIT
BB1B
a) 2*1 ppb
b| 9* ppb
•) 27S « oc - 1*7
»g/g
b) 293 » or - 1*3
ng/g
c) 2*0 * oc - 130
ng/g
« 296 » oc - 2*2
ag/g
•) 1*7.3 » oc - 58
>g/g
(I 226 » oc - 102
•g/g
•) (.67 ppa (*6X)
b) 3.21 ppi (»9«)
c) 6. 56 ppi (58%)
PUGB)
QBIBBlt XBfOBBHXOB
•1 COBtCOU
b| IdlXt-oaiat Uaictlc*
Ocivitila, MtokcA foe «9« cat •»,
fcoi Bangkok. Ikalluo. BUB ag* *3
1C (29-7«|, ran height 62.2 inch**
(59-67). MBB «t 132.1 Ib (95-177).
BltlLS; CBBOBIOB; BKBi TBUUBO;
CX18BTIS
•) lociU. cklUcaa, Uu tkac 2 to
gcaat«c thin 7 jr. iomit !•*•!• in
2-7 yc oltm
b) naa«c»*igkt cklUcvB, <2 to 7 yr
c) B*ll-aoicl*k«a alalts, 20-35 yc
1) Subject!. 45-885 yc. fcoa
inatltmtioa foe tka ag«4
•) Ckcoatcally ainblaa. 30-70 yc
f) ocag aodleta. «S-70 yc
Subject* of facloa* ag««, health, and
nitcitlOBal atatu fcoi >ackty.
CBBOBXOB; fOKBI; Bill! 01111; MB;
imUTZOBU OBTXCXIBCIBSi CBXLOBKB;
10DLTS: COBPIB1TXTB BT1L01TXCBS; DBDO
ICOSB; BBTtlS; BXBIS; TUCB H.1BBITS
le«ie»
BlfXBB; BBTIISI TBICB BUBBB1S:
COPnB; B»B6IBB5B| SBlBIXOBi
CBBOBXOB; U1BOSI; VBtOS; BIOOB
flUBki BBTTBBOCTTBSt HX1K( 1ITBB:
OIITBD KIIODOB; IDIlIIIOIil.
DIIICXIICXES; aiBXOfXC H.OID
a) lo eenal diaeaae
bl teat* cenal Callacee
c) Chconic cenil failacea
Ocy »t baaia
Peccant of aaaplaa «ith detectable
!***!• ia Indicated in pacentheaea.
intopaiea at OCL> Boapital.
IBkCB BUBBITS; BBTtM; tOIOtSXBSl
CUirOUTl; (XDBBISi tXTBB) SPIBBI;
OISUSBSj BtPBITBBSXOB; SOD10S;
ranssxoit CIKXOB: CBOSVBOBOS;
8iaBBSX08; CIOBXOB; UK; COEPBBi
lltOi nOI| ailQllISB) tLOHIIDB;
SXIXCOIf TIT1IIDI; COBtHi IICKBL:
801IBOBIOR; Till CBBOBXOB; SnOITXOB;
BIBIOBi lltBIOBl SXlfBBi TIUBIOB;
BCIOI
unuicB i
1
Beajanavatca. I.K.
Bannlon, B.
197S
Gacaon. C.T.
Sanac, 8.
Beets. B.
«0lf, B.B.
Soknea, S.
1975
Shav. J. C.I.
1980
Indcapcaait, s.
tlexandec, G.T.
aonick. B.C.
197*
Ul
-------
Chroalu
7MO-«7-3
Cr
»tl 51.996. IIP 1900 C, B? 26«2 C. TP 1 •• 89 at 1616 C, 10 m* 89 at 18«0 C
(COITIIOBD)
TISSIJl
19«B
11 wr
1">»9
Long
1950
Lang
1951
Lug
BIPOSOHB BODTB
llttTTICU.
8BTHOD
BS
I
ES
BS
US
IORBBB
or cuss
30
.. _
20
-
•I 10*
bl IS
1IIG1
•1 lot glT«n
b| lot glT«n
c) lot gltaa
lot datactabl»-22.6 ag/g
dry «t
•at glT*B
•) 3.6-11.5 ag/g dry *t
b) lot glfu
(nit
mi
a) 2.1T ppa (»5*) .
bl 3.86 ppl («1X)
cl 3. 82 pp. (29S)
lot gi*a>B
8.7 ig/100 9 ACT
a) 6.5 ag/g dry *t
b| 3.* ag/g dry *t
NOD
IirOIBlTZOII
al lo c«aal di««as*
b| teat* c«nal failarci
c) Chronic canal fallacu
Dry »t baala
P«rc»nt of atiplva «ith d«t«ctabl*
laials la Indlcatad la pac«ntha>««.
«otop«l«» at OCLl Bospltal.
HaCB ELBBBITS; BBttLSi lOTOfSIBS;
CltlFOBIII; nDIETSi LITER; SPLBB1;
OISElSIS; BTPEBIBISIOI; SODIOH;
POUSSIOB; ClICIDS; P80SPBOIOS;
IIGIISHI; C1D8IOI; ZIIC; COFPBB;
II»D; IIOI: BilCllfSB: aLORIIUBi
3IIICOI; TIT1II08: COBILTi HCKIL;
BOLTBDEIOHi Til; C8H08IOB: S1BORIDB;
BIIIOI: tiTfliua: SUTII;
BCIOI
Sactloaa of langs fcoa >abj«cta who
had b««n bitnalnoa* coal alnar* for
23-50 yr.
BITUS; TMCI BIBBERS;
IISIOR; BtlTUIOB; BOIOI; CB80SI0B;
COPPEI; OEBBtKOB; IIOI; tHI;
BlOIESIOa; HtlOllESI; lICKEli
SI1ICOI; SJlfBi; Til; T ITU I OB;
UMDIOR; LOKS; COlt: DIITBt STUBS;
QOtlTS; BIIEIUS
Incladci appar aod low«r lotau, and
lyaph goda* of l«ng. tdditlcnal data
atallabl*.
Sactlona of lanqa troa aabjacta «ho
had b«*n bltgalnoga coal alatea for
12-50 yr IB lalalgh Coanty, last
Vltgtal*.
BtTlLS; TlkCI ELBBEITS; COU;
BIlILLIOa; COB11T; CBlOBIOBl COPVEB;
IICI; lEaDi B40I1SIOB; RllQinsi;
IICRU; TITIIIOB) flMOIOB; tllCi
IOIOS; COIFIIMITE intOITXOIS;
SnlCt; QDIITt: ITBPI IODES: 1B3T
Tiieiiu
a) coal aloaca
bl coatrola
Sactloaa of Ivags tro« AacaaMd coal
alnara and noa-eoal alaar* froa
laUlgk Coaaty, IT.
BFTUS; tltCI BIBBBIT3; COU. I SlUCt;
BIITUIDB; CltoiIOB; COPPIl; IIOI;
iitDt ajQiBsioB; iiioinsi; ncni;
TITHIOBl TillDIOH; XI 1C; LOB9S:
COBHIITITB mtoinois: IBSI
TIMIIU
BBfEBEICB
Indrapraait, s.
llaiandac, S.T.
Gonlck, B.C.
197a
Crabla, J.T.
(••aaa, B.C. •
lolonici, P.B.
Xnott, B.J.
Bolts. 3.1.
Gorakl, C.B.
1967
OJ
(••nan. B.C.
Crabl*. J.T.
Saallvood, i.i
Carlbarg. J.8.
1971
S*a«t, D.T.
Croaa*. I.E.
Crabl*. J.T.
Caclborg, J.I.
Lalnhart, i.s.
197«
-------
chroalaa
7MO-«7-3
Cc
Itl SI.996. I* 1900 C. B» 26 « C, Tf 1 •• Bg at 1616 C. 10 aa By at 11*0 C
(COBTXIOBD)
TISSOB
1952
lang
1953
Lyaph
a ode
195*
Spleen
195S
Oclne
BIPOSOIB IOOTI
ItlLRXCll
IBTBOD
BS
BS
BS
IOBBII
OF CISBS,
109
1*
-,
a| 1
b| 1
BIN!
3.6-11.5 ag/g dry it
lot ginn
a) lot given
b) lot given
c) lot given
a) 0.3-1.2 ag/2» he
b) lot applicable
(HIT
•BIB
6.7 ag/g ary at
2.6 as/100 9 dry at
a) 6.72 ppa («0«)
b) 2.11 ppa (*2«)
e| 5.37 ppa (3«»)
a) 0.7 ag/2* he
b) 1.1 ag/2« he
PUB)
8BIIUI XtFOBMTXOB
Baage of aeana. Idditional data
available.
Sections of luga fron deceased lest
f irginla bitasinoaa coal aiaara.
BBT1L3; TlaCI ItlBBRS; COI1; SXUCIi
BBIILLIOIl CBBOIIDB; COPPBB: XBOBs
IHDt BlOIISIOBl BIBOlBBSBt IXCBBL;
TITMtOl! VlllDXOB; SXICi 10 IB Si
CCBP11ITIVI miOlTIOIS; IBS*
VXBeXBXI
Palaoaacy hilar lyaph nodes (roa
•abject* (ho had been bltaaicois coal
alaera foe 12-50 ye in Baleigk, lest
Virginia.
RR1LS; TItCI BtBBBBTSj COIL;
BOntlORt COBILT: CBIOBXOB; COPPBI;
IIOI; LBIOS BIQIISXOI; BIBOiHSB)
IICIIL; TITinOB; TlllOXOB; IIBC|
IdiaS; COBPUMIfB BVlHHTIOISl
SXUCtj QO»TS: IIBPB MOBS; IBST
fIBOXIXk
a) lo renal disease
b) teate renal fai lares
c) Ckconlc renal failacea
Cry it basis
Percent of saaplea »lth detectable
levels is indicated in parentheses.
Intopsies at ncn Rospital.
TMCB niBBITSl RBT11S; 10TO(SIBS;
CIlXPOBIla; IIDIBTS: LXTBB; SPLBBBS
DXSBISBS; BIPBBTBBSTOI; SOW OH;
tCTlSSIOB] CIICIOB: PROSPROBOS;
BISIBStOI; CIDBIOI: «IC; COEPBB;
H»D: noi; aiioticsB: tioixioRi
SIIXCOI; TITIIXOI; COBtLT; IKKEL;
BOinOBBOB; Til; CBBOHIOB; SnORXOB;
elBXOI: 1ITBIOR: Sltni; TtltDIOB;
eoioi
a) Healthy sale. 5 sasples o«ar • so
b) Realtky faaale
Idditional data available.
BIIUS; TllCI ILBBBBTS; IISBHC;
IIOIXIB; CllCXOa; CBMIIBBl COBILt;
CBIOBXOB; CBSXOB] COPPBI; RBKOII;
IOBIII; POTISSIOB; IIISIKSB; SODIOB;
IOBIDIOBS SIUIXOB; II 1C; OBHB;
EtlSOBlaBIT BRBODS
BBnBBBCB
caclbecg, J.B.
ceable. J.v.
Listiaca. l.P.
lorris. I.B.
Bolts. 4.1.
Baser, p.
Bolaiicc. P.B.
1971
Keeaan. B.C.
Crable, J.v.
Saallsood, I.I.
carlberg, J.I.
1971
Xndrapraslt, s.
Alexander, 6.V.
Bonick. B.C.
197*
Cornells, B.
Speecke, a.
Haste, J.
1975
LO
-------
CaroBlae
7MO-»7-3
Itl 51.996, IP 1900 C. W 2612 C. TF 1 » Hi at 1616 C. 10 •• 89 at 18«0 c
(COITII010)
TISSOE
195*
Orlne
1951
Urine
IX9OSOIB 100TB
alaLTTIClL
SETBOD
US
us
RDBBBI
or cists
a) 31
b) 17
cl 5
d) 19
•) 10
l\ 5
189
Ilia!
a) lot given
b) lot gitea
c) lot given
d) lot glten
•) lot gives
f j lot glvea
•) lot gives
b) lot glim
c) lot glTu
BEII
a) 1.52 * or - 0.89
«g/dar
b) 1.«2 » or - 0.68
ag/dar
e) 3.08 « or - 1.9
mi/day
d) 2.77 » or - 1.11
ag/dar
•) l.ao » or - 0.92
ag/dar
f) 0.91 » or - 0.38
ag/dar
a) 0.*8 » or - O.«1
(SI) as/1
b) 0.3* * or - 0.31
(SI) ag/1
cl O.*1 • or - 0.37
(SI) ag/1
OBI1UL IHOIBHIOI
a) loraal children, Uu thai 2 to
graatw tkaa 7 jr. Ex era t loo
incnaMd iltb ag«
b) Ondnntgbt chlldran. <2 to Ijc
e) lall-noarlahcd adalta, 20-35 jt
d) Sabj«cti, aj.es jr. froa
lutltatloB for tb« ag«d
•1 Chcoaleallr dUabclcd, 30-70 jt
(I Drag addict*, «0-70 re
3abJ«ct« of »ario«» ago, health, and
aatrttioBal statu froi Tarkcr.
CBtOBIOB; T01IBT: Ball: OBIII; 108:
loinnoiu DinciiiciBs; CBHDIEIJ
aBOtTS; COBMIaTIfB BULOaTIOISi OIOG
ICD3B; BBTilSl DXBIS; TUCI nsnlTS
a) Bal*« (9
-------
Ckcyiotll* (• ci) (fil)
Catyaotll* (1H93(S1209) ] (9 CI)
13001-21-5
BW-09-S12.3lg
II 212
nisBi
1958
ing
1959
lug
1960
Saliva
IIPOSBBB BOOn
.
Inkalatloa
1B1LTTIC1L
BBTBOD
Bicroacopy
Bicroacopy
BDBBBB
OP CISBS
a) 13
b) 7
•1 1
b) 1
1
I1BQB
a) Bot givu
b) lot gl»aa
a) Bot glvan
b) Bot glv«a
Bot given
BSIB
----
a) 1JO. 000/9 «n lug
b) 160.000/g dry lug
a) 3 I 10(B*6)
fibara/ca ••
b) 2 I 10(B«6)
10|B*6) fibara
_
ailBUl IIFOII1TIOI
a) plttabatgk taaldaata
b) Ubaatoa aotkara
FIB BIS; (SBBStOS; IOB03;
PBBBSTLTaBXI; SORB CltOLIB*;
OCCOPUXOm BllllDS
b) Bala
faraackyaa ftoa 39 yt old fa aala fitk
3 yt of aipoaara aad 20 yt
foataxpoaara to ckryaotila atbaatoa.
aad 68 yt old aala vita 13 yt
aipoaaea and 12 yt poataxpoaora to
ckryaotila aabaatoa. Franca.
•BBB9SOS: IOBOS; S*»*l; 1DOITS;
FBllCI; FIBIISi IB VtTBO 1B11TSXS
Spataa ftoa 38 yt eld aala altb 10 yt
•ipoaara and 9 yt poataxpoaora to
ckryaatila aabaatoa. Franca. Onlta
not glvan.
ISBBStOSl tOBflS; SUIT*; IDOHS;
FltlCB: PIBBBS; IB TITBO 4BIITSIS
UFBIBBCE
6toaa, p.
Barlay. I.I.
Davia. J.B.O.
Cnllay, I.J.
197*
•laetaad. B.C.
Blgnoa, J.
Sabaatlaa, p.
Seal. J.
1977
Jaaxud, B.C.
Bigooa. J.
Sabaatlao, p.
Son!, J.
1977
VO
-------
ceil (lo poitlnga in CBBBLIBI) .
TISSDB
1161
long
1962
Lug
1963
tmg
196*
Lang
IMS
mag
BXPOSOBB S00TB
IBiLTTICtL
BETBOD
—
.
lOHBID
or CISBS
30
» 30
b) 26
c) 23
d) 21
•) 16«
b) 1*
MS
26
- -
B1B6B
0.5B-12.«OS
_
a) 580- 12*00 no/ 100 g dry
•t
b) (30-13230 19/100 g dcr
•t
e| 310-12070 ig/100 g dry
»t
1) 520-13220 ng/100 g der
•t
•) 2.7-6.3 g/100 g dcr «t
b) lot glr«D
lot gl»*n
•30-13.230 ig/100 g ttj
•t
BEIB
a. 92*
.
•1 B980 ig/100 g dtr
•t
b) S397 ag/100 g dcr
•t
c| 3*68 Bj/100 g dcr
«t
d) 56M ag/100 g dcr
it
a) «.6 g/100 g dcr wt
b) 2.9 g/100 g dcr »'
«.* g/100 g dcy «t
5,397 ag/100 g dcr >t
OEIIttl IBrOBBITIOB
facccntag* of 2 g gcoand, dci*d
laagi.
Section* of l«ng« tcoi ••bjccts cho
had bMB bitaiinom coal iln<» foe
23-50 re.
BITILS; TBACI BLSBIBtS; 4L01IBOB;
ElBIOfl; BBBIILIOBJ BOIOf; CHTOSIOH:
CCPfBB: OBBBIIIOB; ZBOli Hit!
lUOIBSIOB; B1IQ1IB5B; BICXBL|
SIlICOl! 3IKEB; Tilt Till 1108;
VIHDZOli LOBOSj COtt; DIITBE SMTBS;
OOlBTt; BlltltlS
a) iprll and Bar 19«5
b) Kacch 1966
c| DK 1966 to Bacch 1967
d) Bo* 1967
additional data atallabl*.
Section* of lug* fcoa «ab].
BBTILS; IIIlllLSt BniLLXOHl COULT!
COtrilt ItOBj IBID; BIOBBSIOB;
BIIQlllSft BICIBLl TITtnOB;
flBlOXVIt IIBC; COIL; LOBOS; 1B3T
TiBoiBii; lotatsns
BBrEIEBCt
Ccablt, J.T.
KMnan, B.C.
•olovlcx, F.B.
Knott, B.J.
Bolt*. J.L.
OOClU, C.B.
1967
(••nan. B.6.
Ccabl*, J.».
Siallirood. l.».
Caclb*cg. J.B.
1971
Smot, D.T.
CCO9M. I.S.
Ccabl*, J.T.
Caclb*cg, J.B.
Lalnhact, v.s.
197*
Caclb*cg. J.B.
Ccabl*, J.T.
Llatlaca. 1. P.
loccl*, B.B.
Bolts, J.L.
Bamc, P.
tolovlcz, F.S.
1971
Ccabl* , J.».
KMUB, B.s.
KlBMT, K.B.
SuUnood. i.f.
Ba«*c, P.».
196*
(IBR HOB)
JS
O
-------
coil (to postligs U CHIHLIII) .
(coRlltno)
-55551 —
1966
nod«
1967
Lyipk
Biiosm towi
1B1LRIC1L
BBTBOD
BDBBBB
or CISBS
•I 23
b| 13
5
B1BOB
•I 150-5820 cg/lOO 9 «ry
wt
b) 7W-7WO ig/100 9 tfj
wt
..
630-S.MO 19/100 9 dry "t
BB1B
•) 2391 ig/100 9 icy
«t
b) 3900 19/100 9 dry
•t
5,397 «9/100 9 4ry >t
SBIIBll IBIOBB1TIOB
•1 Dae 1966 to Bicek 1967
b) lov 1967
FilMMry kilir lyipk oofl«i fro*
«ibj«et« wko kid b**a bltiitnou coil
•liiri for 12-50 yc In Bilclgk. t«at
Ticglali.
BRUS; TB1CB BLBBBBTS; COIL;
Bnntxoi; coBiiT) cnouom COF?BB;
HOB; IBID; BMBBSXOB; B1I01IBSB;
BICKBL; TltlBIDI) V1B1DIOB; IIBC;
tOBOS; COBVkUtin BTlUntlOB;
SILICli QOIBTS; ITBPB BODBS; IBST
TIBOIBZ1
TilaM foe liMri lltk 21>(7 yr
ocoipatlanil •zp«ri«nc«.
Ilniu froi d«o«ii«d lut Tlrginli
bltulion coil ilur*.
BMUS; BXBBB1LS: BBBTUXOB; COB1LT;
CCHBB; IBOB; LI1D; BISBBSIOB;
BIB81BBSBI IICIBL; CXTinOB;
TIB1DIOB; SIK; COIL; 10BBS; IBST
TXBGIBI1; 10TO?SIBS
BBVBBBBCB
KMUn. 1.8.
Cribl*. J.T.
SMllioaa, 1.1.
1971
Ccibll. J.T.
n»in, B.C.
Unnc, B.B.
SllllWOOd. l.B.
RlMC. P.I.
I960
-------
Cobalt
7MO-«8-»
Co
ttl 58.9332. H? 1*13 C. 9t 3100 C, TO 1 •• 119 at 1910 C
TISSUE
1968
Blood
1969
BlOOd,
••CM
1970
l»lt
1911
lUaar
BXPOS01B ROOTB
..
IBMLYTXCiL
IBTIOD
II
US
u
BS
IOIBBB
Or C1SBS
•1 728
b) 691
IB
11
BIBOg
__
a) Bot girra
b) Bot glvaa
S.6-9.B ng/al
0.53-2.83 ppa
•) Bat glt»
b) Bot gi*an
e) Bot gi*m
(BIR
BBtB
a) 0.00* * or - 0.00*
•9/9
b) 0.003 » or - 0.00*
«9/9
7.7 ng/il
1.70 ppa
a) 1.12 ppi (11*1
b) 1.03 ft* (13*1
c) 1.SS ppa (15*)
tUI)
GBBH1L inOBBMIOB
•) aatvcaal
b) Fatal
Cry «t baila
Siaplaa froi » koapltala la
lllhTlll*. TB.
PlICBBTli BBTUSl 1BKB BlBintS;
1IBBBSSIB! 8100D; BlUt; COBPil»TI»B
BftlOITIOBS) RBBCUBT; LMDi CIOBingt
SllBBIOli BOBIOIOg; IBOB; SXKi
COBUT
...
Billtkf AOBOM, ag«d 23-53 jr.
Blood <«apl«a pcoTldad by Oafcicto I
B«glooal Boifltal. lacona. Italf.
BMUS; RIBOUBSBi COB1LT; CCPPBB;
BIOCO; BtOOD 3BBOB; ITtLT
Scalp kale
Deaoc* froa t tillaju of Balka
ladlau in tba laaionai Tatcitoclw
at T«»ia«li.
Bill; TIBBSDIUt BBtUSj TBtCB
BlBBBBtSl SODtOBl KOBXBOB; SllXCOBi
CaiOUIBI COTtSSIOB; SUBDIOBt
HtlBIOH; TtBtDIUB; CBIOBIDB; OOlDj
BMOtBBSB; XBABs COBHTl BXCIBtl
COPPB1: IIICj IBSBIIC; SBlBBXORl
BIOBIIB; B01IDIDB; STBOITIOB! SILTEBt
1BTIBOBII IOBIBHJ CISHJB; BaBXOBt
IIBTB1BDB; CIBIOB; SUlBXOBl BHC01T
a) Bo canal 4i»aaa
b) le«t« <•••! fallma
c) Ckcoalc caaal Catlina
Otj «t baala
Parccnt of aaaplaa iltk datactabla
!•«•!• im ladleat«d IB pac«ath«M«.
latopalaa at ocil Boapltal.
TBICB BtlBBBlSl BBltLS; kOTOISIBSl
ClUPOBBXtt HOBITSt lITBBi SttlBI:
DISB1SBSI BTIBBTBBSIOB; 500X01 1
POttSSIOBi CtlCIOBl fBOSflOBBS;
BlOBBSIBBl CIOBIOBt HBCJ COItBB]
tHDt IBOBj BlBOHBSIi 110BIBOB;
SILICOB; IXIUXOII COBUTl IKIKl
BOLTBDBBOB! Till CnoBXTIBj SHOBtlOB)
BUXOBi LXIBXBB; SnTBB) TkBUXOBl
BOBOB
BBFIBEBCB
Baglaa, l.J.
Bral, i.B.
Schalart, 1.
Illaon, 0.
LacMn, (.
DT*C« B.
Btncoac, B.
sehaffaw, B.
BoffMO. I»
Daflaa. J.
197»
Buiaralli, ».».».
Boccbattl, B.
1975
Parkooa. ».K.
Talandla, J.I.
Diana*. B.
1977
Inlrapcaalt, s.
llaxaadar, O.T.
eonlck. B.C.
197*
•
JS-
N3
-------
Cobalt
7MO-M-*
ktl 58.9332.
1«93 C, BP 3100 C. TF 1 » Bg «t 1910 C
(CORXBOBD)
HSSIB
1972
Line
.
1973
Lug
197*
Flaoaita
1975
Splvaa
BXPOSOn BOOIB
IIURXCU
BBTBOD
ts
BS
II
BS
BOBBBB
OP CiSBS
26
83B
11NB
•) lot gl»«B
b) lot gin*
e) lot gl*«a
lot gl*an
lot gl»«n
•I lot glT«n
b) lot glvn
c) lot glT«B
(IBR
BBIB
•) 1.06 ppi <11«)
b) 1.17 ppi (1«S)
o) 0.97 ppi (19S)
1.9 19/100 g dry *t
0.023 « or - 0.01S
«g/g
a) 1.00 ppa (10S)
b) 0.97 ppa (9*|
e) 1.02 ppi (91)
fiat)
SEElBkL XBIOBUnOB
•) Bo rnal dl*au«
b) lcit« nail (allmi
c) Cktoale rasal fallar**
Ocy lit baili
farc«Bt at iaapl«i with d«t«ctabla
litopiiaa at OCL1 Boapltal.
TBICB BLBIBITS] BltklS; IROiSIBS;
ciuroinit CXBIBTSI LITBB; STLBBB;
EHtkSBS; BIPBITBBSXOB; SODIDBi
(OtUSXOBi CUCXOB; PIOSPBOIOSi
BkaiUIOBi CaDBXOBt IXBC; COPPB1;
IMD; IBOIj BkEBklUB; klBBXIOB;
SXUCOI: THMXOB; COBI1T; BKKBL;
BOLYBDBBOB; til; CBBOBXOB; S1BORIOB:
BIBXUBj LITlIOa; SILTEB; TkBUXOB:
BOBOB
Sactloa* o( liBga (COB (abject* *ko
kad bail bltialaoai coil Blaac* (oc
12-50 yr IB laloigk Co«nty. Hit
flrglal*
BRUS| TBlCl UIBBRSl COIL)
BntllXOII COBkltl CBBOBXOB; COPPBI;
HOI I IBID; llQIISIOBi BkB«inSB|
IXCKBll IXTinOBl tlBaDXOBl HIC:
I010SJ COIP1B1TXTB BT1L01TI01S;
SXlICll QDtBtl! LTBVB 10 DBS I IBST
TXIOXBXk
Diy «t ba*ii
Saiplaa (to* • koipltala la
Bukvlll*. Tl.
rilCBRki BBTU.S; IB1CB ELBBHTSl
TIBBBSSBBl BIOOD; BUS; COBFIBITXVB
BUUtnOBS! BBBCBBI; 1UD; dDBXOB;
SILEBXOB; BOBXDIOB; XBOI; IIBCj
COBU.T
i) 10 nail 4J.MM*
t) lent* eaBil fallma
c) CkcoBlc raal fallocas
Dty «t bull
Farcaat of laiplai ulth datactabl*
laral* 1* iBdlcatad IB par«Bthai»i.
litopalra at OCL1 Boapltal.
TBICB BLBBBRBj BBTUS; tOTOFSIES;
CllXPOIIXll BXOIBTSl LITER; STLEBBJ
CXSBISBSi BTPBITBBSXOli SODIOBJ
(OTISSXOBt CUCXOBs (BOSPROBBS|
BI6IBSXOB: CtDBIOB; BIBCj COIPBI;
tlkO; 1101; BIISIIESE; klOBIBOB)
SItlCOB: TXT1BXOB; COBkLT; 1ICKBL;
IClTBOBBOBl TXI; CBBOIIOBi SHORXOB;
IIIIOB; LltBIOa; SILTBB; TkllDIOB;
BCBOI
BBTBBB1CB
tadrapcailt, s.
klvxudar, B.T.
OoBlek. B.C.
197«
(•aaaa. l.Q.
Crabla, J.T.
Saalliood. k.B.
Caclbarg. J.B.
1971
Baglaa, B.J.
Brnl. k.B. .
Sckilact, k.
IllaoB. D.
LacavB, K.
DyoCf B.
Baocoir. B.
Scka((B«t. I.
Boffaan. 1.
Dafl**, J.
197a
XBdcaprialt, s.
tlaxaadaz, o.T.
Ooalck. B.C.
1971
-------
Cobalt
7MO-*l-«
Co
Its 50.9332. HP 1*93 C. BP 3100 C. YP 1 •» |g at 1910 C
(COBTIIOBD)
TISSUE
1976
OclB*
siPoniE soots
KILYTXCll
BETROD
II
-
•ami
or CUES
•) i
W i
urn
•1 O.S-2.2 «g/2« hr
b) 0.6-0.9 «g/2« he
mi
k) 1.0 ag/2* hr
b) 0.8 ag/2* hr
amut IIFOIBITIOI
•I BMltky nl«, ( suplai owr 9 10
t) Bvilthr «••»!«, 2 >alpl«l 10 10
•f«rt
lldltlaatl flit* «nll«bl«.
BBTU.S; TBlCe BIBBBIT3; liSEHC;
BlOUBBi CILCIUBi CBtOIXIIi COBU.TJ
CBHOBIOS; CISXOR; COPPB1; BBiCOBtj
IODIIB; POTISSIDR; BII9IIESB; SODIOR;
IDBIDIOBl SIMIXOIt StK; 01IIB;
BHSOIBBBBt BBTBOBS
nmiicE
Cora»ll>> B.
Sp*«ck«> 1.
Bolt*, J.
197S
-------
Cl
Btl i3.5««. I? 1083 C. IP 2595 C, Tf 1 •• 19 at 1(28 C. IB » Bg at 1870 C
tXSSBB
1977
adipoM
1978
IBBlOtIC
(laid
1979
IBBiotlc
(laid
1980
lorta
_
1981
Blood
BUOSOBB BODTB
1IURXCU
BBCBOD
I-ray «p«ctroa
US
X-ray spactroa
US
BOBBBB
OP CUBS
'
137
. ....
9
72
__
lot givm
0.0 6-0. 2C PPB
lot givan
a) lot glTBB
b| lot glTaa
c) Bat gl*m
d) lot giTaa
B) lot givaB
() lot gl*m
(IBR
sn
0.52 PPB dcy «t
0.1* PPB
5.88 ppa dcy vt
B) 229 ag/100 Bl
b| 199 ag/100 al
cl 206 ag/100 Bl
d) 51 ag/100 al
a) 51 ag/100 Bl
C) 52 ag/100 al
PIOI)
GIIII1L XBTOIBHXOB
IbdoalBBl (at. 2 naplu p*c COB*.
2 BBBlyBO* pOX BBBplB.
197B BBtOpBlW Of 10 PlBB IBUBBB. B
Papago. Bad a Cnatk XadlaB*
POTlSSIftB; CILCIOBt XBOB; COIPBBt
IIIC! BBBXOXOIt lICMLj LIIO; BRUS;
1UCI HIBIITS; II fill SPIBSI; lOIIl;
IXDBBTS; BDXPOSB TXSSVB; PtICBIM;
•USniBRBBT BRBODSl IOTDPSII5
l«ral( did Bet ebBBga appcaclBbly
dariag pcagBaacy. aoc aac* thay
BlgBldcBBtly dl((«c«at bvtwaaa Ugh
cl«k Bad Bocaal gcoapa.
1*7 *OMB altk high rick oc nocBBl
BRlLSl COPPn; IBItOTIC PLDID; BLOOD
SP.IOB: PIBBI4KT
lafio
IITIII; BBTUS; IBaCB BLBBIIISi
CBBOBXOli IIIBOBB; PRBS; BtCOO
PUSBt; BBTtBBOCytBS; Bill; IXTBB;
OIXTBD KIIODOBJ BD1IXTXOIU
DIPXCXIICXISi BlIXOTXC PLOIO
2 aaaplva pac CBM. 2 analyaBB pac
BBBpl*.
197« BBtOpBlOBI 0( 10 PlBB XattBBB, B
Papago. Bad a Crank ladlaa.
POtiSSXOR; CILCIDB; IBOI; COCPBI|
BIBC; 10BIDIOB: BICBBli LBID; HRM.3;
TIICB ELI HITS; LXTBI; SP1BBI; lOITa;
IIBIBISI 10XPOSB TXSSVB; PIBCBBtSt
BI1SOBBRIIT BBTBODS; 1DTOPSIIS
B) Blood (COB 22 aethBCB, lo« birth
at groap (1500-2500 g|
t| Blood (COB 50 aothaca, aoraal
birth at gcaap O2SOO gl
c) Blood (COB 22 aotkara. aoraal
birth at gcoap aatckad vita to* blctk
•t groap (or MI, aatarBal aga, raco.
aaoklng habit*, parity
d) coed blocd CCOB 22 aothara. lov
birth «t gcoap
B| Coed blood (COB 50 aothari. BOCBB!
birth «t graap
() Cord blood (roa 22 aothara, aoraal
birth at groap aatehad with Ion birth
at gcoap (or MI, aatomal aga, ram.
aaokiBg, kablta. parity.
Bothara aha ga»a birth IB Maark, IJ,
Iprll-SBptaabac, 1975.
BRUS; CllCIOB; CBIOBIOB; CCPPBI;
IIOI; llOIISiaa; UK; BLOOD; 1DOLTS:
PROS! IBI JIBSBT; CORPMaTXTB
IftLOtTIOIS
BBFBUICB
BugalMB, I.P.
Bill, B.B.
BiaLaoa, K.B.
Batoagh. D.J.
CkrlBt«BBra, J.J.
laatt, l.B.
BlehacdB. D.o.
1979
Shearer, t.B.
LIB, B.I.
JOhBBOO, K.S.
JOhBBOB, J.B.
ProB-cott, e.B.
1979
Shav, J.C.L.
1980
Bang«l«oB, l.r.
Bill, B.f.
Bialooa, K.K.
Batoagh, D.J.
ChrlBtoaMa, J.J.
Iiatt, B.B.
BichacdB, D.O.
1979
BogdBB, J.D.
ThiBd, X.S.
toap, P.I.
Catarlnl, B.
1978
Ol
-------
ccpnor
7MJ-SO-8
Co
Itl 63.5«6. g? 1083 C, BP 2595 C. TP \ an 19 at 1628 C, 10 •• 89 «t 1870 C
(C01TIIOBD)
TT3SOE
1982
Blood
1983
Blood
198*
Blood,
cell*
1985
BlOOd.
plena
1986
Blood.
plena
1*87
Blood,
plena
B IPO 301 B BOOTI
tiitmciL
RBTBOD
US
-
us
us
us
-
IOBBBB
OF CtSBS
a) 29
b) 19
1*5
2
a) 20
b) 33
BIBGI
a) 0.71-1.31 ppn
b) 0.87-1.«1 ppn
0.90-1.36
Ian?* of ••an*
w
a) lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
a) 78-150 B9/100 el
b) 75-166 ag/100 el
BUB
a) 1.03 ppa
b) 1.1* ppa
1.1* ppe
a) * eg/100 el
b) 29 ag/100 el
c) «6 ag/100 el
d) «7 ag/100 el
*) 110.0 eg/100 el
b) 1U.O ag/100 el
_ _
GBIEBtl IIPOBBITIOI
leflei
BltlLS; COPHI; IBOI; SKJIES10H;
IIBG1EESB; IIIC; BBTULOPBOTtllS;
IBBORUOID HTRBITIS; BBTXBI
a) 0-) fr old hoepltal patient*
b| (-6 yr old hospital patient*
Dutch anbjact* aoed 2 10 or elder.
IITIIS; CaDIIOB; CCPPEBj IBOI; IBID:
BIEOIBBSIS IIBC; BIOOD; BLOOt SBEOB;
SBOUBO; OBIL COITIICBPTIVES:
IIOOST1IBS; SBItTBIS: 1DDT.1S;
CBUDBBB; SIXl IBTBBBllBDS
l**ie>
EIHBI: IBTUS; IBICB BtBBMIS;
CCCPEI] BaBGIIRSE; SBiniOB;
CBIOBIIR: IBI8ORI; FFIOS; BLCOD
PUSIa; BBIIBBOCtTBS; Mil; IIVBB;
OIIIBD HB8DOB; BOtlXTIOItl
omciiiciBSi iBBiotic FIOXD
Iddlttonal data available.
Bealtky adult* not felting, aged 19
to 51 yr. (roe Siaden.
BR1LS; IIBC; COPPHt BIOOD: BIOOD
PlaSlai Slim; DBIIaBR) SBX; 1001TS
a) Patient 1, after 9 no of diarrhea
end 6 *k of patenteral alleeetatlon,
before In therapy
b| Patient 1, after oral In, 35
•g/dey, 10 day*
c) Patient 2. after 6 no of diarrhea
end 5 ik of perenterel alleeotation.
before In therapy, d) Pa tie it 2.
after oral In, 35 ng/ day, 10 day*
Infant* treated for Intractable
diarrhea.
22-25 day* after «tart of treatnent
patient* b*ea*e feferiik. B**h of
•rytho**, feeiclee. deaaded (etche*.
and peitale* developed aroend aateral
orifice*, genltolia, perlnean.
finger*, aad toe*, llopecl*.
blepharlti*. and paroaychla. Baah
and fever reiponded to oral dec.
Strikiag decree,** 1* **re* alkaline
pko*ph*ta*e. Beponded to oral tiac.
IIIC! BIOOD tlaSUl COPPIB: SIH
DXSBISBS; BITU.S
*| Bale*. 65-9* yr old, (ithcet
vltuU *epple**nt
t| Feeale*. 65-95 yr old, ilthoet
fitailn *eppl***nt
IGI: BIOOD; BUB; XBBUDi BRlLS;
TIlCB H.BBIITS; TXTMXBS
BBFBBBICB
Sorencon. J.B.J.
1978
Xielhel*. B.t.
del CalUlho, P.
Barber, B.F.R.
libovo. I. I.E.
1978
Sh*«. J.C.t.
1980
Bather. >.
•alleniu. K.
ibdalla. B.
1977
irakeve. T.
Taanra, t.
Igara*hi, T.
Sasaki, 1.
S*nd*te*d, I.B.
1976
--
fir, s.c.
love, 1.1.0.
1*7*
(HIT fiOl)
-------
Ca
Itl 63.546, BY 1083 C, B» 2S95 C, TP 1 •• Bg at 1629 C, 10 » Bg at 1(70 C
(coniiuiDi
tzsara
1988
Blood.
plaaaa
1989
Blood.
plaaaa
1990
Blood,
1991
Blood,
aeraa
1992
Blood,
saraa
uposm BOOM
IULRIC1L
IBTBOD
US
US
us
us
BVBBBB
OP CUBS
al 6
b) 12
C) 16
d) 20
a) 9
f) 9
9) 2«
k) 21
a) 5
b) 5
35
119
BIMI
al 0.70-1.65 ag/al
b) 0.70-2.22 ag/al
c) 0.83-1.91 ag/al
4) 0.7C-1.97 ag/al
el 0.95-1.78 ag/al
f) 0.70-1.53 ag/al
21 0.71-1.18 ag/al
| 0.6»-1. «6 ag/al
a| lot given
b) lot given
a) lot given
b) lot given
c| lot given
4) lot given
0.9-3.0 ppa
(IBXT
8>kl
a| 1.303 ag/al
b) 1.382 ag/al
c| 1.307 ag/al
4| 1.303 ag/al
a) 1.379 ag/al
f) 1.101 ag/al
g| 0.891 ag/al
k| 0.99* ag/al
•) 13* ag/dl
b) 83 ag/dl
a| 672 ug/1
b| 60* ng/1
c) 926 og/1
4) 1337 ng/1
2.02 ppa
PIOE)
OIIIIU. XIPOS81TXOI
Baviei
EEVIBI; BBTILS; TBICB BLBBBBTSj
COPPBBl BlEBinSI; SBLBBIOBt
CIBOflXOBl BIIBOBBl Fit OS! BLOOD
PllSlk; BBITBBOCIIBSi BILK) llfBB;
OIITBD IZWDOB; BOIBITIOBHi
D1FICIEICII3; IBBTOTIC FIOID
a| S-<10 yr old aalea
b| 5-<10 yr old reaalea
c) 10-<15 yr old aalea
d| 10-<15 yr old teaalea
•) 60* yr old aalea
f| 60* yr old Can* lea
g| Ctneaaiana old 11-17 yc aalea
k| caacaaiaaa, 11-17 yr old fa aalea
Iborlginea. 5-77 yr old, fron
Bonnjaa aad Pitscoy Croaaing
connanltlea of l.l. laatralia.
Biddle-claaa Caacaaian children aa
ceatrola.
BLOOD SBBOBl BLOOD PUSBll tIBC;
COPPBB; IBOtl IBTaLS; lOSTIklXa:
exits; iei; CBXLDSBi: tooits
a| loaaa taking a coabiaatioi oral
coBtraceptive, after 35 days OB diet
b) loaaa not taking a contracaptive,
after 35 daya on diet
Diet contained ao In, Ca, Fa, bat naa
otkernise natrltlonally adegatte.
Soaa aabjectat diarrkea, aora
tkroat, atoaatltia apktkoaa.
IIIC; COPPtl; BBT11S; BITIOOni BLOOD
SlEDBl OBIL COITlaCBPTIVBS; tBOTBIIS;
BKlBOLISB
a| Day 1
b| Day 2
c| Day 10
d| Day 20
35 barn caaea. 15-61 yc. Ivtrage of
3>* of body aarfaca barat.
IIIC; COPPEB; BLOOE SBBOB
lavala did not ckaaga appreciably
daring pregnancy, nor aere tbay
algnitlcantly different betvaan klgk
rlak and noraal groapa.
1*7 loaen vltk kigk rlak or ooraal
pragaanclea.
BITUS; COPPEB; 1BIIOTIC fLOlD; BLOOD
SlIOB; PBBOB1ICT
BBPIUICB
Skav, J.C.L.
1980
Bolt, ».B.
Spacgo, l.B.
Xvaaon, J.B.
Paalkaer, 8.S.
Ckeek, D.B.
1980
Baaa. F.B.
King. J.c.
Bargan, S.
1977a
LaFargae, t.
coatare. J.c.
Boatail, B.
Onilbaad. J.
Salioa, L.
1976
skearer, T.I.
Lla. B.I.
Johaaoa, K. S.
Johnaon. J.I.
Preacott. G.B.
1979
-------
ca
Itl 63.5*6. IP 1083 C, BP 2595 C. »P 1 aa Bg at 1628 C. 10 aa Bg at 1870 C
(COITIIDBD)
TISSOB
1993
Blood,
Mina
199*
Blood,
aaraa
1995
Blood.
aaraa
1996
Blood.
aaiaa
IXPOSOIB IODTB
Ingaation
Ingaatloa
1BUTTXCU
8BTBOD
US
IIS
:
us
us
IQBBBI
OF CISBS
187
«1
1
f
1
18
RaIBB
a) lot giTan
b) lot gitren
.
at 91-98 ag/dl
b) 105-110 ag/dl
c) 180-186 ag/dl
..
a) lot giTan
b) lot giTan
c) lot glTen
d) lot giTan
1.0-1.* ag/al
(lilt
mi
a| 110 ag/100 al
b) 12* ag/100 al
a) Rot applicable
b) lot applicable
c) lot applicable
a) 201 ag/dl
b) 136 ag/dl
c) 21* ag/dl
d) 180 ag/dl
1.2 ag/al
rial)
eillllL mOlHHIOl
a) Ban
b| loaoa
Criteria for lov latela < 75 ag/100
al.
loral otahna, 58 aaa, 129 «oaan. aean
age 69 yr.
DIRS: TB1CI ElBBEnS; CBOIBSTBBOIS ;
8100D SBR08; II 1C; COPPEB; PCT1S3IOB:
SOOX08; 810IESXOR; CllCXOB: JSOIj
VIT1BXI 1; fXTllXIS
a) Coatiol. 2 aad 6 hi attar 50 ag
IB. Faating Talna, 96 ag/dl
b) Ciiihotic, 0 aad 2 hi attar 50 ag
IB. Final Talue, 108 ag/dl at 6 hi
c) Poataargical gioap. 0 aad 2 hi
after 50 ag IB. Fiaal valae. 185
ag/dl at 6 hi
111 groapa faated before In.
controla, patlante alth alcoholic
cirrhoais. poataarglcal patlcnta alth
delayed healing.
tllC; CISBBOSIS; 01X11; BIOOC;
IIBBISKI; BJSX TXBGlm; SOBCEBI;
CllClna; B1SIESIOB; COPPEB; niCB
ElEBEITS; DIOOS; BBTltS; IITH:
DISBISBS
a| 16 hi after ingaation
t) Ceraloplaaa-boand fraction 16 hi
aftei ingaation
c) *0 hi attar ingaation
d) Ceialoplaaa-boaad fraction «0 hr
after ingaation
2 yc old patient adaltted to hoapital
1 hi after diiakiag 30 al
aoperaataratad coppai anlfatt
aolatlon
Peritoneal dlalyala ataited 17 hi
attar ingaation.
Beaolytic aaaala. renal fall ace.
cardiac arrhythaia. central nernaa
ayatea depreaaion
8RUS: COPPIt; BBIU, POXSOBXIQl
BUWD SBBOB-, 111811) BIOIOLOOXC
BIIIFESTmoiS; USB RXSTOIXtS;
CBIIDIBI; C1I1D1
Baalthy donora, agad 21-53 yr.
Blood aaaplea prorlded by Oabarto I
lagional Boapital, Incona, Italy.
BRUSt BliailEIE; COB11T: CCPfBRs
81000s BIOOO SE10B: Mill
RBFEIBICE
Flaher, s.
Beadiicfc*, D.E.
RahoBoy, »•'•
1978
SolllTan, J.F.
Jetton, 8.8.
Borch, B.E.
1979
Cole. O.E.C.
llraaaan, D.s.
1978
BaxxareUl, R.i.i.
Bocehatti, R.
1975
00
-------
c*
50-8
Its 63.5*6. at 1083 C. ft 2595 C. Tr 1 •• Bg at 1628 C, 10 •• Bg at 1870 C
(conxmiD)
tlSSDB
1997
float.
aaroB
1998
Blood.
aaraa
1999
Blood.
Oaroa
2000
Blood.
•oral
2001
Blood.
aoraa
sifosan BOOTS
Ingeatloa
Injection
1BILTTIC1L
BBTBOO
US
118
us
us
us
•IIBBBI
OF CUBS
8
122
2*
al 16
b) 9
c) 13
41 7
•) 1*
f) 15
19
B1MB
87.5-92.* 09/100 ml
a) Bat gi»«n
b) lot glfea
o) lot given
•) Bet given
bl lot given
e) Bat given
d) Bat given
e) Bot gl»«n
f) Bot given
-
a) 1.30-2.22 ag/al
b) 1.37-2.01 ag/al
c) 1.20-2.16 ag/al
d) 1.20-2.17 ag/al
•) 0.95-1.55 ag/al
f) 1.02-1.82 ag/al
•) 50-18» og/dl
b) 32-1M ag/dl
(•BIT
BB&B
Bot given
t) 11*. 3 * or - 13.7
ag/100 •!
b) 107.0 » or - 23.7
ag/100 al
el 103.* » ot - 19.1
ag/100 il
•I 1. ag/al
b| 1. ag/al
c) 2. ag/al
d) 1. ag/il
•) 1. ig/»l
f) 2. ag/al
a) 1.655 ag/al
b) .690 ag/al
c) .*92 ag/al
d) .630 ag/al
a) .273 ag/al
f) .391 ag/al
a) 106 » or - 11
ag/dl
b) 76 » or - 7 ag/dl
(SB)
PlOE)
SSHIIL XBIOtBttXOI
Baaa valaea all gcoapa daring «
aipaElaoatal period* of * days oaok.
Sabjact* raeaiTod 2.93 (2.90-2.96) ag
ca/day cltk tual dirt or «lth basal
dlat pla> 1*.2 g/day npplaaaat
callaloao, aaainllaloa* oc pictla.
Saall ekango* IB aozaa coat«ot oc
azlaacf oKecotioa daa to oxtxa Ubac,
•Igattleant ekaugoa la Meal alaanl
loaa.
••altkr adolaaeaat boya
aniLS; MIC I BlBflBBtS; BI1BM13;
COPFBI; tllCj BtaBBSIVBi BIOCO SBBOB;
DBXBB; FICIS; tDOtBSCBBTS; FIB BIS;
CCBMBtTIfB miOlTIOBS; BBBBlSm
. .
a) Stong* bettor? norkara baCora
traataaat altk xlac and vltada C
b| Caatrala
c) Storage battory aorkora. attar 2*
ak troataoat alth xlac and vltaola c
lorkara. agad 28-60 yr. ia battory
plant «-3* yr. 100 control* tilth no
kBon Pb •zpenra.
IUD; IIIC; COFPBI; BBIkLSi niCE
SIBBBBTS: BICOD; BIOOD SBBOB| IBOI;
BBBOGLOBXSS; OBIIBJ OIBTS; VITlBIB C
i) 1-3 ao lactatloa
b) «-6 ao lactation
cl 7-9 BO lactation
d| 10-15 ao lactation
•) 16-21 ao lactatloa
f) 22-31 10 Jactation
•bit* ooatn, 1-31 ao poctpartaa.
HOOP SBBOB; ULX; BkXB; BBtlLSi
IlCTtTIOB; CIKIQBi BtOBBSXOli
BIBOtBBSBi XBOBj CCPPBB; IIBC
•) 5-<10 yr old aalaa
b| 5-<10 yr old taaalaa
c| 10-<15 yr old aalaa
a) 10-<15 yr old CaaalM
a) 60* yc old aalaa
f) 60 » yr old faoalaa
akorlglaaa, 5-77 yr old, froi
Bo«anjaa» B.B. taatralla.
BIOOD SBBOB; BLOOD BLISS*; SIBC;
CCPPBB; XBOB; BBTalS; IOSTBI1I1;
CUTS; tBEl C8XLDBF.S; IDOLTS
a) Pro-total paMBtoral aatrltlon
b| Darlag total parontaral nutrition
|!-*2 daya)
Copper content of kyporallaoatatlon
tlald, 20-30 ag/1. significant
dacraaaa In taraa attar 2 vk. P<0.02.
Cincar patlanta, «gaa 12-63 yr, aaan
• t loaa of 18.9 » or - 3.21 Iroa
pra-lllnaaa night.
IIIC; COPPBB; RBIllS; BIBBBll
BITiBOLISB; BLOOD SSMD; U1IIB;
lEOPHSnS; CIBTS
BBfBBBBCB
Draaa, L.B.
Uaa, c.
FO*. B.B.
1979
Papaioannon, B.
Soklor, 1.
PfalCtar. C.C.
1978
Taagaan. L.I.
Vobar, C.B.
Kanbarling, S.B.
1979
Bolt. i.B.
Sparge, B.B.
Inaon. J.a.
Faalknar, 6.s.
Cbeek, o.B.
1980
/
Lonry. S. F.
Ooodgaae, J.T.
Salth, J.c.
Baher. B. a.
Rakack, B.B.
Bankin, B.I.
Brannan, B.r.
1979
VO
-------
ceppot
7MO-50-*
CO
ati 63.5«6, IP 1083 C, BP 2595 c. »P 1 aa 19 at 1626 C. 10 •• 89 at 1870 C
(COtrilOBO)
TISSUB
2002
Blood,
•kola
2003
Bale
200*
H.ir
2005
•ale
200C
Bait
•
BIPOSOII ROOTB
aBlLTTICM.
BBTBOD
its
Ik
US
-
us
us
B0BBBB
OF CISBS
33
11
6
a) 179
b| 108
c) 102
4) 109
a) 27
b| 76
cl 7
d) 35
MIOB
1.0-1.7 ag/ll
2.5-102.0 ppa
•) 20-MO ppi
b) 23-510 ppi
c) 30-«10 ppa
a) lot 9l*«B
b) lot gl*sB
e| lot 9l*oa
d) lot 9i»«B
a) 6. 7-22. 2 og/g
b) 6.*- 25.« ag/g
e| 8.8-30,* «g/g
8) 6.9-19.7 19/9
(Bin
IBll
1.3 og/Bl
IB. 2 ppa
a) lot glT«n
b) lot glfsa
c| lot glvaa
a) 9.92 «9/9
bl 17.91 «9/9
e) 13.87 ag/g
d| 25.06 ag/9
OooMttie sonns
a) 11.1 09/9
b) 12.3 09/9
« 19.6 eg/g
4) 12.0 19/9
HOB)
CEUIIL IIPOBBlTXOI
• •althr .«.
Tolandla, J.I.
Dlsnss, 1.
1977
Bass, D.
Pat*. B.D.
1976
Craason, J.P.
Blnnoca, T.i.
Basgaraar, J.B.
PlBksctoa, C.
1975
fit. S.C.
io*s, i.B.a.
1979
!
•
Ul
o
-------
7Mg?SO-8
Cl
It* 63.5M. CT 1013 C. BF 2S9S C. TP 1 en Bg at 1628 C, 10 » B9 «t 1870 C
(coitzmm)
TIS5BB
2007
Bale
2008
Udney
2009
Kidney
2010
Liver
.. -
BnosMl BoOrdJ
-
IBUTTICU,
BBTIOD
US
X-cny apectroa
BS
S-cny apactroa
BQBBEB
OF CUBS
12
a) 135
b) 73
0 88
10
BIKE
n) Bat given
b) Bat given
c) Bat given
d) Bat given
e) Bat given
n) Bot given
b) Bot given
n) Bot given
b) Bot given
c) Bot given
Bot given
BBIB
•1 18 ppn
b) 37 ppn
c) 2* ppn
d) «5 ppn
e| 31 ppn
n) 10.1 ppn dcy it
b) 10.3 ppn dcy vt
a) 12.6 ppn
b) 9.23 ppn
c) 11. • ppn
3». 2 ppn dry ot
OBBBBIl IBPOBfllTXOB
a) 1-6 no lactation
b| 7-9 no lactation
c) 10- IS aatha lactation
d| 16-21 no lactation
e) 22-31 no lactation
Bklte vonen, 1-31 no poatpartna.
(IOOD SBBOBi BXlKl BaXBi BB91LS]
IICTITIOI! CalCXOBt BlOIESIOB;
BIBQ1BB3B; HOi; CCPPBBl SIBC
a) Bndnlln
b) Cortei
2 nanplen per cane. 2 analyaea pec
aaapla.
1974 aatopaien of 10 Finn Indiana, a
fapago, and a Cceek Indian.
FOttSSXOBl CILCIOH; IBOIj COCPBBt
tXBC| BBBIOXOB; BXCKBl; 1UO; BKaLSi
IBaCB BtBBBBtS; LXVBB| SPLBBB; kOBTii
BXOBBIS] IDIFOSB IISS9I; FMCBBaS;
BIMOBBBBBt BBTBODSi 10TOPSI13
a) Bo cennl dineaaa
b) tcate renal failarea
e| Ckronic renal failarea
a| and b) dif Cerent, b) and d
different. K0.01
fallen are dcy vt bania.
Intopnien at OCLi Boapltal.
TBtCB ELBBBBiS; BBMIS; tOTOISXBS;
CILIFOMII; BXDBBTSt LCTBBl SPIBBBJ
BISUSBSi BTPBBTBBSXOB; SODIOI;
•CtWSIOBl CtLCIOB; PB.OSPBOBOSI
BiaBBSIOBl CtDBIOB; tXBC| COIPBB;
IHOj IBOB) BMOUUBl llOBIIDH;
SX1XCOB] IIIIBXORt COBUT: BKKBL;
BOinDBBOBl TIB; CBBOBXOBl SnOBTIOBl
IIIIOB; tltBXOB; SUTBBj VkBUXBB;
BOBOB
2 nnnplen pec cane. 2 analyaaa pec
nanple.
197* tntopnien of 10 Una Indians, a
Papago. and a Cceek Indian.
POTUSXOBt CUCIOBi XBQBi COP7BI;
IIIC; BOBIDIOR; BICKBL i tBaD; BBtllS;
TBtCB SLBBBBtSi LIfBij SPLBBB; HBTkl
KIDBBTS; tOIPOSB TISSQB; PkBCBBU;
BMSOBBBBBT BtTHODS: tOTOPSIIS
BSFSBBICB
Vaagkan. L.t.
tebec. c.B.
(eibecling. S.B.
1979
Bnngelson. B.P.
Bill, B.B.
Blelnon. K.K.
Batongh. D.J.
Chrlatauen, J.J.
lutt. B.B.
Bickarda, D.O.
1979
Xndcnpcanit, s.
lleiudar, O.T.
oonlck. B.C.
197«
Bnngeleon. B.F.
Bill. B.B.
Blelnon. K.K.
Entengh, D.J.
Cbrlateasen, J.J.
Xtntt. B.B.
Bickardn. 0.0.
1979
(•BIT PiGB)
-------
7OO-50-8
Co
Itl 63.5*6. BP 1083 C. BP 2595 C. TP 1 aa Bg at 1628 c. 10 aa Bg at 1870 C
(COITXIOSD)
TXSSOB
2011
line
2012
U**r
2013
lug
201*
lug
2015
laag
B IPO SOI B IOOTI
-
IBM, RICH
BBTBOD
BS
BS
US
us
BOBBBB
or CISBS
_ .
a) 92
b) ««
el 76
30
20
a) 85
b) 15
UIGB
a) lot glT«B
b) lot glvan
e) lot glTrn
Bot 4atactabla-78.6 og/g
dcy «t
Bot gl»aa
a) 7.5-12.9 ag/g dry it
b) lot gl»an
(BBII
lltl
al 23.7 ppa
bl 22.* ppi
cl 22.8 ppi
lot gins
.
7.5 ag/100 g dcy it
a) 9.7 ag/g dcy it
b) 1.2 ag/g dcy it
MOB)
6(11111 XITOBRHXOI
a| no canal 41aaasa
b| Icata canal failacaa
c) CkcoBlc canal Cailacaa
Ocy it baala.
lotopaiai at ocu Boapital.
TI1CS SLIR1ITS; BBTUS; iOTOISIBS;
CILiroilII; IIDIET9; LITBI; SPIIBI;
DXSBaSIS; IIPBTBBSIOB; SODIOH;
[OT1SSXOR; C11CXOB; PBOSPBOIOS;
fllBIBSXOB; C10RXOB; UIC; COIPBB;
KID; HOI; BIB01II3B; U.OBIIDB;
3ILICOI; TIMRIOB; COB III; IICKBI;
BOIIBDBBOBJ I XI J CRIOIXOBj S1IORZOB:
BI1XOB; IIIBIDB; SXtTBBi T1IIDX08;
BOMB
lailan. Fatal tiaaaa
iiTXBi; amis; TIICB BLBRBIIS;
COPPBBi BIBOtlBSB; SBIBBID8;
CBBOBIOB; BBIBOIBj PROS; BLOOD
PUSBI; IITTBIOCItlS; Bill; llfBS;
OIITBD II 10 DOB; nniTIOMl
EirxcTiiciBs; innoTic H.OXD
Sactlona of luga (coa anbjacta nko
kad baan bitaalnoaa coal aln«c» foe
23-50 yc.
BBTUS; tllCI BIBBBRS) HOBIIDBi
BalXORl BBBTLLIOB; BOIOI; CBtOBXOI;
COPPBB; OBBBinoBi INB; IBltj
BiaiBSIOB; HIOalBSI; BXCIB1;
SX1ICOI; SIITBB; TXB; TM1IIOB;
TII1DXOR; IOIOS; COll; OIXTBC SUtIS;
COaHl: IXIBIUS
Xaclada* oppac aod lowac lobas, aad
lyaph aoda* of lang. tdditlowl data
aiailabla.
Sactioaa of langa troa aabjacta iko
kad baaa bltaainoaa coal aiaara foe
12-50 yc ia lalaigk Couty. Baat
BITllSl TB»CB BlBIBRSl COllj
BIITLtni; COBlLI; CBIOBZOBg COPPBt!
HOB; IltD) ItaiBSXOBl B1I01IBSB!
•XCHUl TIT1ITOR; T1UDIOBI niC|
IOIOS; COBP1I1TITB BT11V1TIOB;
SXlICi; QDlBttl ITBPB MDBS; WEST
Tnaxixa
a) Coal alnaca
b) Coatcola
Sactloms of lug* fcoa 4acaa*a4 coal
aliaca aid BOB-coal alaaca fcoa
lalaigk Coaaty, IT.
IRUS; TUCI BIBBIRS; COIL; SX1XC1;
BIITLUBB; cnOBIOIl COPPII; IBM;
ISIDl BiaiBSIBB; BlNllBSB; HCXVL;
IXMIXOB; TtllDIOB; SXK| LOIBS;
coBPiiitiTB mioinois; list
inaxixi
UniBICB
XBdcapcaalt, S.
llataadac. C.T.
Goaick, B.C.
197*
Sbai, J.C.I.
1980
Ccabla, J.T.
laanan, B.C.
lolovici. P.E.
uott. I.J.
Roltc. J.I.
Gocakl. c.B.
1967
IMUB, B.O.
Ccabla. J.T.
SMllvood* a. V.
caclbacg. J.I.
1971
Svaat, O.T.
Ccoaaa, I.B.
CcabU. J.T.
Caclbacg. J.I.
Lalakact. I.s.
197*
1
to
-------
Cl
ktl 63.S«6. BP 1083 C, BP 2595 C, Tt 1 aa Bg at 1628 C. 10 aa Bg at 1870 C
"TXSSOI
2016
laag
2017
lyapk
B04*
2018
Bilk
. . ..
2019
Bilk
2020
Bilk
ixpoatu BOOIB
1I11RIC11
BBTBOD
us
us
us
118
BOB BIB
0V C1SB
90
al 28
b) 39
c| 23
4| 13
•1 28
fl 30
al 76
b| 77
c| 23
4) 77
•1 25
SIMS
_..
7.5-12.9 ag/g 4ry vt
lot glT»
al tot given
b) lot given
e| lot gives
d| lot gives
•) lot given
ft lot given
al lot glf*n
b) lot given
e| lot given
4| lot given
•1 lot given
(IBXT
mi
9.6 ag/g 4ry *t
7.7 ag/100 g Icy at
al 0.*3 » oc - 0.05
ag/Bl
b| 0.33 » or - 0.03
ag/al
el 0.30 « or - 0.03
ag/al
4| 0.2* » oc - 0.0*
ag/Bl
•1 0.29 » or - 0.08
ag/al
t| 0.28 * oc - 0.06
ag/Bl
al 0.«6 og/al
bl 0.29 ag/al
c| 0.16 ag/al
4| 0.29 og/al
•I 0.3C ag/al
MOB)
QIIIUl IIPOIB1TIOI
laag* of Man*. Iddltional data
available.
Section* of laag* fro* deceased Mat
ficglala bitialaoaa coal alaer*.
BRllSl TIICI BIHIITSi COllJ 8X1XC1:
anninii CHOBXOB; coppitj xtoia
mo: aioBBsxoi; BiiaiBBSi: ncnit
IITllIOBi TlMDXOBl IXBCi 10 BBS;
CCSP1B1HTI ITlUlTXOBSt BBS*
Pilioaacy kllac lyapk aodea tcoa
•abject* «ko kad been bltaalBaaa coal
Binec* foe 12-50 yr In Raleigh, lest
Virginia.
BBtUS; VB1CI B1IBBRS: C011;
B Elf 11X0 B ; COBlUi CB10BXOB: COPPSS;
1MB; 1B1DI 810113X08! B1IG1RSI;
BXCKBlt fXTlBXOBi UBIDXOIt UBC;
xoiasi coipiBiTin BTIIOICXOB;
SILICI; QOlBTlj 1TBPI BOOBS; BIST
TXIOXBI1
*) 1-3 BO lactation
b| «-6 BO lactation
c| 7-9 ao lactatloa
4| 10-12 aontk* lactation
e) 13-18 ao lactatloa
f| 19-31 10 lactation
Ikite VOB*B. 19-»2 yr age. 22
pclalpacae and 16 aaltlparae, 1-31 ao
poatpactaa.
BIOOD SBIDB; Bill; BBT11S; tkCTITIOIj
81X11 CllCXOBl B10BBSXOB: B1NUBSB;
IlOli COPPIBi IXBC
•I Coloatcas, klgk and Ion Incoae
gcoap*
b| Iftec lactation 1-3 Booth*, high
•nd lo* iBeoa* gcoapa
c) Iftec lactation > or - 13 aoatka.
klgk and loe Ucoa* gcoop*
d| Iftec lactation 1-3 aontha. lo*
IBOOBB gcoap
e) Iftec lactation 1-3 aoatk*. klgk
Incoa* gcoap
Slgnl (leant difference (P<0.01)
bet>een IBCOB* gcoap* at 1-3 aontk*
bit not at *-6 aontk*. Additional
data available.
Ba**n fro* icban and cacal India.
BITtlSl TBICI BlIBBITSl COPPIB;
BIOIBSIOBl tnC; BI1K) COBPlUtXTS
BfllOITXOBS; OIB1B I1B1S; BOU1
II81S) XIDXI
l«*l*«
lITTBf: BBTI1S; TIICB IIEBSBIS;
COPPBI; I1BOIISS8; S81SIXOB;
CB108X08; BBIBOSI; PROS; BIOOD
PUSH; BBTTBIOCTTIS; KIB; II»IS;
OIIT80 IliODOB; BOTBITXOI11
DiriCIIICXBSi 1IBXOTIC PIOXD
BIPIBBBCB
t
caclbecg. J.B. I
Ccable, J.T. |
llatlac*. l.P. |
lorrl*. B.B. I
Bolts, J.I.
Baaex, P.
loloilcx, P.I.
1971
Keeaan. B.C.
Ccable, J.T.
saalliood, 1.1.
Caclbecg. J.B.
1971
taagaaa. 1.1.
leber. C.I.
Keabecllng. S.B.
1979
BajaUkaaal, t.
sclkaatia. s.6.
1980
Shan. J.C.L.
1980
Ln
to
-------
Copper
7 WO-50-8
Co
»ti 63.5*6. IF 1083 C. It 2595 C. TP 1 aa 89 «t 1628 I. 10 ll Bg it 1870 C
(COITXIOBD)
TISSOB
2021
•ail
2022
Pancraaa
2023
Sploon
202*
Sploon
2025
•oath
BXPOSOIB BOOTB
-
tltLTTICM.
BBTIOD
It
X-ray ipoctcoa
- - - -
X-ray *poctro*
BS
BOIBBB
OT CISBS
a) 50
b| 50
c) 3*
d) 23
*
- -
al S.*9
b) 6.02
o| 5.51
al 28
b| 28
IIIOB
a) lot gitoB
b| lot glvon
c) lot gi*oB
d) lot glfoB
lot gi*oa
lot giroa
a) lot glron
b) lot gifOB
c) lot gl»on
a) lot gl»on
b) lot gl«ea
(IBIT
BBkB
a) *.3 ag/g dry it
bl «.2 ag/g dr »t
cl ».5 ag/g dry «t
d) 3.8 *g/g dry *t
7. 16 ppa dry *t
5.22 ppa dry «t
.,
a) 5.*9 ppi
b) 6.02 ppa
c| 5.51 ppa
a| 6.6 ppa
b| 6.6 ppa
PIQB)
OBIBItL IIPOIB1TIOI
a) Patkor.
b) letter*
c| Hal* toonagor*
d) p*aal* teenager*
Talve* al*o gi*on for **di*na and
gooaotrlc aaina.
50 Balanaaian Caaillo*. loan ago of
fatkor*, «6 yr, letter*, *1 jr. «3
aalo ckildroB. 12-2* yr and 38 foul*
children, 12-2* ji.
CllCIOB: SODIDB; BtOIBSIUH; ILOBIIDB;
SOIPOB; CHLOUIE; flllDIOB:
BIBBlllSli COPPEt; TUCB BLBBB1TS;
HOOD PIESSOBBt BBI GOIIBli BBTU.3;
lltlS; IlILS
2 aaapl** pot ca*o. 2 aoaly*** par
aaapl*.
197* aatopiio* of 10 Plaa Indian*, a
Papago, «nd a Crook Indian.
POTiSSIOIs ClICIOl; HOI; COPPBI:
IIICj BOBIDIOBl IICKB1; IBID; BBTILS;
SIICB BLBBBBtS; LITBBj SPLIBI; MBTti
IIDIBI3; 1DIPOSB TISSOB; PlBCBBlS;
BUSOIBBBIT BBTBODS; tOTOPSIIS
2 por c«aa. 2 analyaa* por aaapl*.
197* aatopaiaa of 10 Piaa Indiana, a
Papago, and a Crook Indian.
POTtSSIOl; CILCIOB; II 01: COFPB1;
tllC; lOBIDIOl; BICttli IB tD; BBIILS;
1BICB BLBBBITS; 1ITIH 3PLBBI; MBit;
BIDBBTSt aDXMSB TISSOB; PilCHiS;
BUSOIBRBIT IBTBODS; tOTOPSIIS
a) Bo roaal di**a*a
b| teat* roaal falloro*
c| Chronic roaal tailaro*
Dry »t bad*.
l*top*io* at ocit Roapital.
IllCB StBBIBtSl IBTtLS; tOTOPSIBSt
ClLXPOBBIk; HDIETSt tITBI; 3PtlBB|
DISBtSES; BTPBBTBBSIOB; SODIOBl
POTtSSIOB; C1KIUI: PBOSPBOBDSl
BMBBSIOli CtDBIOB; HKl COEPBI;
LltD; IBOI; BtBQtIUB; UOIXIOli
sxttcoBi nttnoii COBIITI iicoi;
BOLIBDBIOI; til; CBBOHIOB; SHOtTIOB;
IIIHB; LXtlZOBl SUTBI; UIIDIOa;
BOIOB
a) Bl Bristol
b| SI Bristol
(orBBBOBt ptoaolat tooth colloctod
fro* ockool dental clinic* in
BcUtol. Onltod Ilngdoi.
ItttLS; LBtDi (IK! CtDUOB; COPPBI i
I1BTB; CBXX.BBBB; OBITBD KXlaCOB
BBPBBBBCB
laoironi, B.
KolrtyohaBB, S.I.
Pierce, J.O.
Schaa*ckala, B.C.
1976
langeloon, I.P.
Bill, B.I.
•ioUon, K.K.
Eatoagk, D.J.
Chrictouon, J.J.
iMtt, I.B.
lickard*, 0.0.
1979
Ra.og*l*oB, B.P.
Bill, 8.1.
llolMB, K.K.
Batoogk, D.J.
Ckrl*toB*OB. J.J.
Izatt, B.I.
Bickard*, D.O.
1979
Indrapra*it, S.
llozaador, a.T.
oonlck, B.C.
197*
stack, B.f.
Barkltt, t.J.
BicUou. a.
1975
-------
7«*S?50-8
CB
ItB 63.516. If 1083 C.
2595 C. TP 1 •• Bg «t 1628 C, 10 la Bg at 1870 C
(CORIIOSD)
ixssm
2026
Brlae
2027
OriM
2028
Vela*
3029
Orlne
istosni loon
Ingestlon
IBllTTICll
BITBOD
n
us
MS
•OBBBS
OF CUBS
aj «
b) 2*
•I 1
b) 1
12
B1KI
a) a-3»7 ugA
b| <«0 ig/1
•) 11.5-18.9 «g/2« he
b) 13-26 ag/2« kc
0.08-0.09 ag/dar
_
•) lot given
b) lot giT«
8MB
a) 33 eg/1
b) Bat glma
•1 15.3 igS2« kr
b) 20 «g/2» be
lot given
a) 0.07 » or - 0.01
ag/dar
b) 0.06 . oc - 0.01
•9/dtr
QBBBBkl XBVOBB1TXOB
•1 tork«» lo lolybdiBlt* canting
Slut
1 Co»tral«->t«aat> Md r«*«rcb
pcnaiMl
Iboit 1/2 tto «ock«n tad dtvrhM.
joint MIDI, btok Mini, knteehM.
••a akin OE talc ckuju.
BlOODl CO101IDO; COPFB1; BOinOBBVB;
BIUTB BIMBDS; IIDOSTUU tUBIS;
OBIEj 8BTI15: TB1CB BUBBBtS
•) B*«ltkr 111*, S «MpI«« OWE * 10
b) 8«ilthy C«ul«. 2 •*•;!•• 10 «o
laaitioMi a*t« •Tiiitu*.
BBIUSt TB1CI BIIIBBTS; 1BSBBXC;
BBOBIBB! CILCIOBi CBMBXBBt COBIUs
CBBOBXOBl CBSXDB: CQPfBBi BBBCOBT:
I08II1; rOHSSXOBl BUBMBSB) SOOXOB;
BOBIOXOB; SBlBBXOBt UK; OlHI;
RB1SOBB8BBT BBTBODS
8MB TBlM* all gcoup* daclng *
•ipnlMBtcl Mclota of » 4*T* oek.
9abj«ct« c«c«l**d 2.93 (2.90-2.961 ig
Ci/d>y vltk buU U«t or «ltk b«B»l
dl«t plu U.2 g/A«T ••Ppl«B«ttt
cillaloM, tulcvlHlOM ot {•ctln.
SMll ek»ng«> IB «•«• content oc
ocinuy excretion dm to •xtn fiber,
•Ignltlctnt ck»nje« la fec«l Bineral
lose.
Beeltky tfloleacent boys
allllS; TBICB BtBBBRSt BXBBIUSi
COPPBB; SXBCt BMBB3XOB! BIO CO SBBOB)
OBXBB; FBCISj IDOLBSCBBTSl FXBBBSl
COBPkMTXtB ntLOlnOIS) BIBIISU
«> Lo« tibec diet
b) Bigk f ibec diet
Ben 37 to *8 re old.
Bean daily balance »0. 2 Bg oc
low-fiber diet and -0.* *q OB
alga-fiber diet
ItQLTS; DBIII; BHalSi TBICB
B1BBBBTS; OIBTS; HBHS
BBFBBBBCB |
i
Ialra»en», p.t.
Bmn-Bnan, B. 1
SOlOBOBI, C.C. |
Chappell. B.B. |
Beatler, a.
1979
Conelie, B.
Speecke, t.
Boat*, a.
1975
Dre», 1. B.
Uee. C.
fox, g.B.
1979
(clear, •*-!••
Jacob, B.I.
Prather. B.S.
1979
(BBIT P10B)
Ul
in
-------
Copper
7MO-50-8
Ati 63.5.6. BP 1083 C, BP 2S95 C. VP 1 a. Bg at 1628 C, 10 aa Hg at 1870 C (CORMROEO|
TISSUE
2030
Urine
2031
Orine
2032
Orine
EXPOSURE ROOTE
Ingest ion
injection
ARALTTICAL
BETBOD
US
AAS
US
BOnBBB
OP CASES
22
9
BARGE
a) Rot given
b) Rot given
c) Rot given
a) Rot given
bt Rot given
a) Rot given
b) Rot given
c) Rot given
d) Rot given
e) Rot given
BEAR
a) 2. » or - 1..
iig/day
bl 25 » or - 1.5
ug/day
c| 16 * or - 1.8
ng/day
a) ..9 » or - 1.5
ag/100 el
b) 6. 0 » or - 2.6
ug/100 el
a) 102 » or - 21
ng/2. hr
b| 117 » or - 2*
•9/2. hr
c) 9. » or - 8 ng/2.
hr
d) 56 » or - 15 ug/2.
hr
el 60 U9/2. hr
(SE)
GEIEBAL IRrOBIIATIOl
a) 8 studies. 21 days each - 1032 ug
c« plus 200 ag ca/day
b) » studies. 21 days each - 1030 ng
Cu plus 800 ag Ca/day
c) t study, 18 days - 10UO ug Cu plus
lEOO sg Ca/day
Bean » or - S.E.
1 study equivalent of 1 case
Balance and other data available.
7 patients vita psychoneurosis. 1
with hypercalcinrea. and 1 with
Paget's disease. H1-63 yr old. All
in good physical condition.
BITALS; TRACE ELEHSBTS; BIREIALS;
CIDBIOH; COPPER; BAB6ABESE; ZIBC;
COBPARATITE EVALUATIORS; FECIS;
ORIRE; ADDLTS; DIETS; BETABOIISB;
IILIROIS
a) Storage battery workers before
treateent «lth zinc and vltaiin C
b) Storage battery workers after 2*
•k treataeot vith zinc and vltaain C
Rorkers. aged 28-60 yr, in battery
plant 4-3* yr. 100 controls vith no
known Pb ezposure.
HAD; ZIRC; COPPER; BETALS; IRACE
EIEBERTS; BLOOD; BLOOD SEBDH; IBOR;
BIHOGIOBIRS; ORIRE; DIETS; 7TTABII C
a) Reek 1
b) Reek 2
cl Reek 3, 6 subjects
d) Reek «. 3 subjects
e) Reek 5, 2 subjects
Daily excretion foe successive >k on
total parenteral nutrition with a
solution containing 20-30 ng/1 Ca.
Cancer patients, ages 12-63 yr. aean
at loss of 16.9 > or - 3.2* froa
pce-illness «t.
ZIRC; COPPER; BETAIS; BIBEBAl
BETABOLISB; BLOOD SERUB; OBI IE;
RIOPLISHS; DIETS
BEFEREBCE
Spencer, fl.
Assnsaen, C.B.
Holtzsan, R.B.
Kraaer, L.
1979
Papaioannou, B.
Sohler, A.
pfelffer, C.C.
1978
u
Lovry, S.F.
Goodgaae, J.T.
Ssith, J.c.
Baher, B. B.
Bakuch. R.I.
Bankla, R.I.
Brennan, B.r.
1979
-------
Cortlaol (8 CI)
Pnon-«-ana-3.20-dloM, 11.17,21-trihydroiy-, (11bat»|- (9 CD
aou-08-«
C21-B30-05
•1 36J.»7. at 217-220 c, coiHcdal aaaplaa 212-213 C
TISSUE
2033
BlOO*.
plant
BXPosoBB BOOTB
Daraal
aiiinxcaL
BBTBOD
Mioroaatry
IORBBB
or CUBS
.
•) 17
b| 15
Miai
«) 2.8-21.7 09/100 ll
b) 2.6-19.7 ag/100 ll
sin
•) 13. 3« of/100 ol
b) 13.01 09/100 (1
SBIIUL IIF01I1TIOI
t) Day 7 of application of
floocinolon* aeetonite
g«n tot* of 7.5 oa/7 aaya ((.1-16.5
•g/7 day«). additional data
atallabl*.
B«altar Infanta, afaa 1 to 30 ao,
• ith non-infactin daraatltla.
DIOOSi 3LOCOCOBTICOIOS;
CCKICOSTIBOIDSi BIOOD SIBOB;
IIMITS; SKI1 DISBISBS; DERRKITIS;
DBtPO TBBBlPIs COBP1BHITE BTILOiTIOBS
BBPBBEICB
(eaton, (.L.
Saaa. ».»., Jr.
Boccla, B.C.
trthoc. J.n.
Blakaaan. G.J.
andaraon, n.
1980
01
-------
Coturln, )-(«lpk«-ac*toiiTlb«xrl)-«-hyaraxy- (8 CX)
2B-1-B»topyraB-2-o*«. •-fcy4roxT-3- |3-oxo-1-pk«BYlbttyl|- (9 CI)
81-81-2
C19-81t-0»
II 308.32. HI U1 C
TXSSOB
203*
Blood.
Mr »
IZMSOU B001B
In9««tlOB
.
UlLTTICtL
BBTBOD
BPLC
8 08 BBS
or cisss
__
2
BIBOB
•I 8ot tppliobl*
bl 6.0-8.8 ng/il
..
HRII
.) 7.2 »g/.l
b) 7.* ag/>l
SIlEItL IirOlBlTZOI
I) VltkOlt D«pCOMD tCMtMDt
b) lltk 37S 19 ntpronn 2Z/diT. 10
di;< b«(oc*-T 4«T« «ft«r SO 19
••rftrin
P«k> «t 5-10 kc tftcc do«».
EitUatvi fcoi gnpk«.
lotul ••!••. B nkltm. 2 blKkc.
•9«a 2«-31 yr.
iDticotgaltat icUtltr not «ff«ct«d
b} D>pcoi«n.
01003 J 0800 IITBUCIIOI; BLOOD S880B;
1 COLTS: ItTXCOkaOLHTSt
IITI-Iin.»BB»T01t KBITS; 1IUQB3XCS;
CCBPtllTlTB miOITXOfS
npBincc
sutt»r, J.T.
U»I. 0.
J«ln, ».
HcSakon, r.G.
1979
00
-------
Coaaarla, 3-{alpka-aoatoarlbaa«rl»-»-kr4roi7-, aodl«a salt (I CD
2l-t-Boacoprru-2-OBe, «-fcj«»iy-3-<3-o«o-1-pfce«rlbBtrl)-. aodlea
• -«•* n*T c
129-06-6
Clt-111-M.Ba
II 331.3*
••It (9 CI)
tissw —
2035
Blood,
plama
2036
Blood .
plaau
iifosni loan
lageatlOB
XagaatLoB
EIILRIC11
BBTHOD
oc
HPIC
n«oroaetrr
lira in
or CUBS
7
12
B1MB
•) lot given
b) lot glT«a
a) 1.6-7.0 m9/»l
b) 2.6-3.3 ag/Bl
c) 2. 7-». 2 «9/>l
d) 1.0-1.6 «»/«!
B>»
•1 1.8 07/1!
b) 0.25
-------
Ccesol (S CI| (T.I)
Phenol, Mthrl- (9 CI)
1319-77-3
C7-H8-0
91 108.10. HP 10.9-3S.S C, Bf 191-203 C, »P 1 •• Bg at 38-53 C
TISSUE
2037
OclM
EXPOSOKE BOOTE
aULRIClL
BETIOD
oc/as
BOB EBB
OF CUBS
26
BHOE
a) lot given
bl lot given
c) lot given
d) lot given
BBtl
a) 29 • or - 22 19/1
b) 62 » or - 30 19/1
c) 3.5 » oc - 1.5
•9/1
i) 1.3 » or - O.a
•9/1
GBIIIIL IIF08IUTIOI
a) p-Cc*sol 16 ilbjcctl, no tola«n»
*lpo««c*
b) p-Cr««ol, 10 »otk«c> 280 pp«
tola«n*
c| o-Cr««ol, 10 noiknra
d) i-Cc««ol, 10 «ock«rs tol««n«
•cck«r •ipoiac** to nan of 280 pp«
tola«n*
2 ik ctidy
a- and p-Cr««ol not detectable In
•line of unexpowd
Toluene In ale and ictabolite in
•tine not linearly related
Otlne not corrected for denilty.
•ethanol also In atmosphere.
BITtBOLISH; IRMOUTIS; OBI IB;
CCRPallTITB STtLDlTIOIS; IIDOSTtllL
1TROSPBBIBS; aElSOBBSBIT KBTBODSl
«NBtlT
BBrBIEICE
loi«ode, ».
Collar t, 8.
Dryck, I.
lalcaardt, B.
1979
-------
Cyanide
57-12-5
C-l
•I 26.02
TISSOB
2038
Blood
2039
Blood
20*0
Blood
BIPOSDBB BOBTB
Ingeatioa
Injection
Bectal
1IILYTTC1L
BRBOD
BOBBBB
or CUBS
1
1
1
B1B8B
Bot gi»en
Bot applicable
a) Bot applicable
b) Bot applicable
HB1I
0.36 ag/dl
9.2 ppa
a) 116 ag/dl
b) SB ag/dl
GEIEBll IBPOBBaTIOB
Beak concentration 1 hr after
•olaatary ingeation of »13 ag pare
ICB.
•B-yr-old aale organic cheaiat.
Cardioreaplratorr arreat,
aarecordatalo blood preeaare, treated
aa diabetic, bat deliberate cyanide
lagastloB revealed by patient after
regaining caaacioaaaeaa.
CHBIDBi BtOOD; MSB BISTCBItS;
IOSTBM.Il
Polaoalag fatality
PESTICIDES: USBBIC; atKUOICS;
CIBBOB IIOlGtITC COBMOBDS; CLOOD:
tlfBl; KIDIBIS; B1IB; tJlIIB; LOWS)
BB1BT; SPIEEIJ BBalB; BLOOD SBBOBj
TBBBBSSBB; CISB BISTOBIBS
a) Coablned blood ample, on
adaiaalon and 6 hr later
b) 12 hr after adalaaioa
Patient had andergone 9 daya of
laetrlle treataeat
Cold aieata, headaches, aaaaea,
lethargy, dyspaea. hypotenalcn,
hypothecate, tachycardia, Xaaaaaol
reaplratloB.
leakocytoa-la. throabocy toala ,
aetabollc acldosia,
electcocardlogcaphic abnoraalitles.
BIOOO; DIOOS; BBaBT; BTPOTBBSIOB;
BHICO
BHIBBBCB
Bdcarda, i.e.
Thoaaa, I.D.
1978
..
Bayes, «.J. , Jr.
Tanghn, ».K.
1977
florae, D.L.
Boroa, L.
Find la r, P.I.
1979
-------
Cjelohexane. 1,2,3,*,5,6-heiochloro-, alpha* (9 CI)
Ctclohexane. 1.2.3.*.5.6-hexechloro-. (1alpha,2alpha.3beta,«alpha,Sbeta,6beta|- (9 CI)
319-«»-S
C6-B6-C16
B« 290.83, RP 159.5-160 C. BP 28* C. »P 0.02 ai 89 at 20 C
TISSUE
20*1
Idlpos*
2012
tdipos*
20*3
Blood
20««
Blood
20*5
•Ilk
EXPOSORE BOOTS
KEklTTICal
RETROD
GC-BC
CC
GC
CC
GC
GC
GC
nc
RUBBER
OF CISES
a) 26
b) 22
C) 27
d) 18
el 18
fl 13
168
57
a) 22
b) *9t
17
UIGE
a) <0. 0001-0. 0«5B ppi
b) 0.0027-0.0580 ppi
c) 0.00*5-0.0886 ppi
d) <0. 0001-0. 0227 ppi
•) <0. 0001-0. 0891 ppi
f) 0.0068-0.6310 ppa
0.001-0.036 09/9
0.11-15 ppb
•) 1-11 ppb
b) lot gl»en
0.1-1.9 ppb
tEll
a) 0.0091 ppi
t>| 0.0091 ppi
c) 0.01°1 ppi
d) 0.0103 ppi
«) 0.01*7 ppi
f| 0.0*97 pp.
0.00* U9/9
3. 25 ppb
a) * ppb
b) < 1 ppb
0.58 ppb
CtlEBAL IIPORRaTIOI
a) Sales - stillborn
b| Bales - 0-11 10
c) Bales - 70* ic
d) males - stillborn
• I Feiales - 0-11 10
() Feiales - 70» fr
Data available tor Intermediate age
groups.
Jtatopsv speelnns, 1967-1971, ftoi
Israelis vita no knovn occapational
•iposnre.
EtSTICIDES; IISECTICIOES; CRIORIIZ
ciomc coBPOOitos: DDT; DDE; DOD;
CIILDIII; BIPTlCBLCR EPOZIDEi IOIPOSE
IlSSOt; ISRlZL; BEIICSLOBOCTCLOBMHE
Canadians (cos Eastecn Canada (16),
Coebec (SO) , Ontario (57) . central
Canada (22) and tester n Canada (27) ,
1972.
rISTtCIDIS; CRLOBXIE ORG1IIC
CC8POOHDS: DCT; EIIIDBW;
tCLICRLORIRaTED BIPBEIIIS; DIE; DDDi
ROIICRLOR; BHACHLOROCTCLORZUIE;
OIKRLORDaRI; RBFTICRIOR BPOUDE;
IOIMSE TISSOBi CliaDl
1975 Tagoxlatia sarTey, 90 sisplns
shoved no alpha-BBC, fellies are for
aaru or plaaaa.
65 sales and 82 Ceiales, aged 8 to 92
jt (lean age *2 jr) in Croatia.
BmCBLSlOCrCLOBtlHE; DDE; CDD; DDT;
PISTICIDBS; BLOOD SEROE; B1OCD
EHS8I; TOGOSLtTIt; CRIORIMTED
BIDBOC1IBOIS
a) Salples in vhlch alpha-BBC us
poaltifelT identified
b) 111 saiples
Pcitiorteis, TirgiBia state Radical
tiaalners Oltlce. 1972. tboot 4S«
Croi ihite sales. 301 froi black
•ales. 151 fro* shite fenlei, 10%
(ros black Ceiales.
CRLORIIB OEQIIIC COBPOBIDS; CDT; DDE;
E1ELD1II; Tllailltj BLOOD;
IISTICIDES; POLICBIOBIMTED
11PBBIILS; lUiCRLOROCTCMBIIilE;
BIPTtCBLOB BPOIIDE: CHtORXItlBD
HTDIOC4IBORS
Bilk sas.pl**, hospitals in arban
Oslo. I sascles fees lalllngdal, a
taller in soithern larva;, la
occapational exposure.
BILKI IRSECTXCIDES; LaCTlTIOl;
CRIORIIatED IIDIOCUBOIS; CR10RTIE
OlOlRIC COBPODID3; PESTICIDES; (ORI1T
REFEREICE
•assersann, n.
Tosatis, L.
Vaasersann, D.
Day, f.E.
Groner, I.
laiarovici, s.
197*
Res, J.
caspbell, D.S.
Robinson, B.H.
Daries, D.J.i.
1977
Keiner, E.
Kraathacker, B.
Stlpcerlc, B.
Stefan ac, Z.
1977
Griffith, F.D. , Jr.
Blanke, R. T.
1975
Balkan, *.F.
seip, R.
1976
NJ
{•BIT PtGS)
-------
Cjclokaxana, 1,2>3.«(S,6-h*Mehlata-, alpha- (6 CI)
Cjclohaiana, 1.2,3,»,5.6-ha*«chloro-. (1alpba.2alpha.3b«ta.aalplia,5bata.6b«ta|- (9 CI)
3»-e«-6
C6-B6-C16
II 290.93. n 159.S-160 C. BP 288 c. fP 0.02 •• 89 «t 20 C
(CORIIOBD)
TISSOB
20*«
Bilk, eat
20*7
Bilk, fat
_
20«8
Bilk, Cat
.
EIP05DU BOVTI
AIALRICAL
BBIBOD
OC-EC
OC-BC
BOBBBB
OF CASES
a| S3
bl 33
a| 3»
b) 6
BAIGB
--
Bot given
a) Bot detectable-0.733
PPB
b) Bot deteetable-0. 016
PPa
.
a) 0-0.27 ppa
b) 0-0.01 ppa
8EAB
0.12 ag/kg
a) 0.107 ppa
b) 0.002 ppa
a) 0.02 ppa
b| 0.003 ppa
GEEEEAL XIPOBBATIOE
IS saaples-eaeh i* average fro a 20
aotkera. Bilk obtained froa lactarla
la Slovakia, 1971-1973. Talnaa
estimated frca graph.
PISTICIDBS: BILK; VATS:
CIECIOSIOVAMA:
RIIACfllOIOCKLOREXAlB; DDT; CDEj
imCBLOlOBBBIBIB
a| 1966-1970 stndy
b) 1977-1978 stadr
1966-70 patlanta. (Dolnrait) of
Alberta Rospital), 2-10 days
poitpartaa. 1977-78 patlante (public
haalth offices of Albecta). 17-309
dafa poatpactaa. Baaldancaa, Bdaontoa
or Alberta.
BIIK; PESTICIDES;
BKACBLOSOCtCLOBIIABB; ODD; CDB; DDT;
CIHLDBIB; REPTACBtOB BPOnDB)
BHACBIABOBinBIBi CAB AD A;
IOLICBL01IBAIID BISBEITLS;
CCBPABATIVB ETAtOAlIOBS
a) Rlgk paaticlde aaage area
b| Lo« pesticide aaage area
loaea living In Starkvllle.
Blaalsslppl (loa pesticide aaaga) and
Delta area (high pesticide aaage).
Saaples In 1973-1975.
BILK; PESTICIDES; DDB; ODD; tDT;
HUACRIOIOCYCMRHABE: RBPTACHLOB
EfOIIDB; OIICBtOSDABB; DIBtDtlB;
EISSISSIPPI; COIPAIATirE BfAIOATIOIS;
RZASOBBIEBT BBIBOD S
BBPIBBBCB
Szokolaf, A.
Boslval. L.
Ohnak. J.
Radarlc. A.
1977
Carrie, B.I.
Kadis, T.I.
Breltkrelts, I.E.
cnnnlnghaa, o. B.
Brans, G.I.
1979
Barnett, B.V.
D'Brcole, l.J.
Cain. J.D.
Arthur, B.D.
1979
-------
Cyclohesane, 1,2,3,«,5,6-h»i«chloro-, beta- (8 CI)
Cyclohaxane. 1,2,3.».5.6-a««chloco-f (1alpha.2beta,3alpha.«beta,5alpha,6beta) - (9 en
CC-H6-C16
BF 290.83. IF 3U-315 c (aeblliea). BP 60 C at 0.58 mm Bg. TP 0.005 » Hg at 20 C
TISSUE
20««
adipose
2050
adipose
2051
adipose
2052
adipose
EXFOSOBB BOOT!
AIALTTICAL
RETROD
GC-EC
cc
GC
GC-EC
GC-BC
IORBBR
or CASES
a) 2C
bl 22
o) 27
d| 18
e| 18
ft 13
168
a) 1*12
b) 898
a) 20
b) 16
c) 22
d) 17
BAIGE
a) <0. 0001-0. 1150 ppi
b) 0.0021-1.0590 ppi
c) 0.0500-2. 9fO ppi
d) <0. 0001-0. 1031 ppi
e) <0. 0001-0. 128* ppi
f) 0.029*- 1.3300 ppi
0.001-1.790 ag/g
a) < or • 26.93 ppi
b) < or " 3.05 ppi
a) 0.0031-7.5794 ppi
b) <0. 0001-0. 355* ppi
c) 0.00*6-0. *6*8 ppi
d) 0.0119-0.3371 ppi
.
(BEIT
REkl
a) 0.01*0 ppi
bl 0.0721 ppi
c) 0.5408 ppi
d) 0.02*8 ppi
e) 0.0178 ppi
f) 0.285* ppi
0.05* ag/g
a) 0.37 ppi
b) 0.21 ppi
a) 0.»232 ppi
bl 0.0631 ppi
el 0.0815 ppi
d) 0.073* ppi
F10B)
GMIBAL IltORRATIOl
a) Bales - stillborn
b) Bales - 0-11 ao
c) Hales - 7fl» yr
d) Feiales - stillborn
e) Fesales - 0-11 10
<| Feiales - 70* yc
latopsy specimens. 1967-1971, froa
Israelis vitb no knovn oecipational
exposnre.
flSTICIOBS; IISECTICIDBS; CHIOBIIE
OIGAEIC CORFOOIDS; DDT; DDE; ODD;
DK1DBIB; BEPTACBLCB BPOXIDE; ADIPOSE
1ISSDE; ISBAU; BBXACRLOBOCICLOBRAIE
Canadians team Eastern Canada (16),
Quebec (50) , Ontario (57) , Central
Canada (22) and lestern Canada (27) ,
1972.
PESTICIDES: CHIOBIIE OBGAEIC
CCBPOOIDS; OCT; DIELDBII;
(CLYCRIOBIIATI9 BIPBCTTLS; DCE: ODD;
IOIACBIOS; RntCBlOBOCTClOREUIE;
OIICBLOBDAII; BEPTACBIOB EPOUDE;
ADIPOSE IISSOE; CAIADA
a) FT 1970
b) Ft 197*
Concentrations on lipid basis.
Fostsortess and biopsies thrcaghoat
O.s.
BILK; PESTICIDES; ADIPOSE TISSOE;
RITABOLITES; CH10IIIE OEGAIIC
CCBPOOIDS: CBIOIII1TED RTDBOaRBOIS;
LACIATIOI; OITCRIOIDAII; DDT;
IOIICB10B; BEPTlCaiOB BPOIIDI;
OIILDBIl; REUCBlOIOCTCtOBEIUE; DDE;
OIITED STATES
a) 0-« yr old
t) 5-2* yr old
e) 25-4* yr old
d) *5» ft old
Bales and fesales
other data available.
Aotopsled tissue (1969-70) froi
individuals vlth tc knon
occipatlonal «pos«re «ho had lived
in the Kaspala region of Ogand*.
FISTICIDIS; CRLOIIIB OBOtBIC
COIPOOIDS: DDT: DltlDIII; RBPTACBIOI
ECOnDE; ADIPOSE 1ISSOB; OOAIDA;
BIIACBLOBOCTCtOBnABB; ODD; COB
BEFEBEICE
•asseninn, H.
Toiatls, L.
Bassersann, D.
Day, I.E.
Groner, T.
laxarovlci, s.
Boseafeld, D.
197*
Res, J.
Caspbell, D.S.
Bobinson, B.I.
Davies. D.J.k.
1977
Katt, F.R.
Strassssn, s.C.
robs, A.R.
1976
--
Bassersann, B.
Toiatls, L.
tassersann, D.
Day, l.B.
Djavaherian, B.
197*
-------
Cyclobeiane. 1.2.3.B,5,6-h«acfcloi:o-, beta- (8 CI)
Cyclokaxana, 1.2.3,»,5.6-be«aciloro-, (1alpha.2beta,3alpha,»bata,Salp*a,6beta)- (9 Ct)
319-BS-T
C6-H6-C16
BP 290.83, BP 31*-31S C (aabllaaa) , BP 60 C at 0.56 •• Bg. TP 0.005 » ttg at 20 C
(COITIIDID)
TISSUE
2053
Idipoia
205*
laipOM
2055
IdlpOM
2056
Blood,
Bar a •
2057
flilk
BXMSOIB BOOM
niLTTiciL
HBTBOD
OC-BC
OC-BC
IDBBBB
or CISBS
•1 26
b) 39
c| 122
dt 99
•1 151
O TO
268
1
•1 25
b) 11
c( 19
4) 10
•1 15
n •»
57
111GB
•) lot gitea
bl lot glTM
c) (at gi*«B
a) lot given
•) lot gi»an
t) lot gi»en
lot given
0.11-0.12 ft*
a) 6-50 ppb
b) 6-22 ppb
c) 5-21 ppb
d) 5-12 ppb
•1 5-6 ppb
f) 9-15 ppb
Trace-O.M ppi
(HIT
nil
» 0.93 ppi
b) .20 ppi
c) .20 ppi
d) .26 ppi
•) .23 ppi
C) .17 ppi
0.208 ig/kg. Tain*
is ladlan.
lot gitam
a) 19.7 ppb
b) 9.5 ppb
c) 12.» ppb
dj 8.8 ppb
•) 5.9 ppb
f| 10.9 ppb
<0.01 ppi
P»C!|
QBIISil XirOIUTXOI
a) 1969
t) 1972
c) 1969-72 (fMlltl)
d) 1969-72 (ulllt
•) 1969-72 (Bulcan-liwrican)
() 1969-72 (BOB H*llc«B-l»clcan)
CatiiDti udirgoing •l«cti*« sorgicy
IB 1969-72 IB th* lo.«t Bio Crandi
hlch paaticidai
•aca (caqaantlr aaad
<) Controla (aalaa)
C) Controls (faaalu)
Idtlt caaldaati of laid County, CO.
(ISTICIDBS; DDT; DOB: LIIDIII;
BIPTlCaiOB ItOIIDE; CRLOBIIB OBGIIIC
CCBPOOIDS; DIHDBII; BLOOD SIBOH;
COLOBIDO; DOST; BSIICBtOBOCICLOBEXIIE
lactattnq >oaen in aalactad tcaas of
BILK; PESTICIDES; IOIPOSE TISSOE;
BITtBOLITES: CBLOBIlt OBGIIIC
COHPODIDS; CBLOBIKtTED RTDBOCIBBOIS;
IICTITIOI; OITCHLOEDIIE; DDT;
•CIRCRLOR; RIPTICHI01 EPOXIDI;
DltLDIII; HIIICRLOCOCTCLCHEIIIE; DDE;
IBKXSIS; MISSISSIPPI
BBfBBBICB
Bacaav J.B.
197*
Siokolay, I.
Boairal, L.
Ohnak. J.
nsdaric, I.
1971
D»»l«a. J.E.
Bargaat, 1.
Fn«d, f.B.
Baqaa, B.
Rorgad*. C.
Sonnabocn, B.E.
Taclafak, c.
1975
Starr, R.G.. Jr.
lldcich, F. D.
RcDoagall. l.D.
Boanca, L.H.
197t
Katx, T.I.
strauaan, s.r.
Toba, k.B.
1 9*^6
CJN
-------
319-R5-7
Bp"290?83. BP 3H-315 C (sabllsesl, BP 60 c at 0.58 aa Hg. vp 0.005 as Hg at 20 C
(COITI10BO)
TISSUE
2058
2059
Bilk
2060
Bilk
—
2061
2062
Rilk, tat
EIPOSOBE BOOTS
ASALTTICU
BETROD
OC
TIC
GC
OC/HS
CC-EC
ROHBES
OP CASES
49
al 23
b| 20
Cl 12
d) 40
e) 38
Cl 19
gl 20
hi 19
a| 10
bl 25
c) 35
4) 10
e| 20
C| Rot
given
33
BARGE
1.2-17.8 ppb
a) Hot given
b| Rot given
cl Rot given
d| Rot given
e) Rot given
C| Rot given
g| Hot given
hi Rot given
a) Rot given
b| Rot given
c) Rot given
d) Rot given
e) Rot given
C| 1-21 ng/g
Hot given
0.009-0.393 ppa
-
(REIT
BEAR
11.69 ppb
a| 6.8 ppa, (at basis
b| 6.2 pps, (at basis
cl 5.0 pps, (at basis
d| 4.9 ppa. (at basis
e) 3. 1 ppa, (at basis
C| 5.0 pps. Cat basis
gl «.9 pps. Cat basis
hi 3.4 ppa. Cat basis
al 1 ng/g
bl 1 ng/g
cl 3 ng/g
d) 2 ng/g
e| 2 ng/g
Cl 2 ng/g
0.49 sg/kg
0.232 pps
PIGS)
6EIIRAL IHPORBATIOR
Bilk sasclea, hospitals in urban
Oslo. » sasples (ros Rallingdal, a
valley in southern Horway. Ho
occupational exposure.
BILK: IRSECTICIDES; L1CT1TIOI;
CBLOBHATED BID ROC ARBORS; CHLORINE
OIOAIIC CORPCORDS; PESTICIDES; IORRAV
a) 1970
bl 1971
c| 1972
4| 1973
e| 1974
(| 1975
g) 1976
h) 1977
(stlsated (ros graph
Bothers In Osaka preCecture
EIPREHTL COBPODRDS; CRLOBIRE OBGAHIC
CCBPOOHDS; OCE; DOT; DIELDRII;
BIIACRLOBOCVCLOBH1IE; J1P1R; HILK;
ECUCRIORIRATID BIPBEITLS
a) Eastern Cana4a
t| Quebec
c) Ontario
d) central Canada
e) Hestern Canada
(| Rational average, sasplea above 1
ng/g
Rational survey, 1975
eiPREITL COBP01RDS; C A MAD A; CRLOBIHE
CIGIRIC COBPOOHDS; DDE; DDT;
DIILDBIR; HEPTACHLOI EPOXIDE;
BlItCBlOBOBERXERE;
BIT1CBLOROCTCLOREIIIE; BILK;
ROHACRLOI; OXTCBLOBDtRE; PESTICIDES;
CCIICRLOIIHATID BIPBEBTLS:
tCLTCBLOIIRIIID TEP.PBERTLS
85 sasples-each is average Ccos 20
in Slovakia, 1971-1973. Values
estisated fros graph.
PESTICIDES: HILK; PATS;
CZECHOSLOVAKIA;
BII1CRLOROCTCLOREXIRE: DDT; CDE;
RtltCBLOtOBEEZEHE
1977-1978 study
Patients at public health offices.
Alberta, 17-309 days postpartaa. 2*
•osen lived in Edsenton.
fllK; PESTICIDES;
RIIaCRlOEOCTCLOREXllE; ODD; CDS; DDT;
DIILDBII; BEPTACHLOI BPOXIDS;
RIXlCRLOIOBEEtBIK; CAR AD A;
IOITCBLOIIEITED BIPBEITLS:
CCBPAIATIVB ETALOATIOIS
BErEBEBCE
Bakken, A. P.
Seip, n.
1976
Takushiji, T.
latanabe, I.
Kuvabara, K.
Toshida, s.
Hori, s.
pokushlsa, s.
Kashlaoto, T.
Koyasa, K.
Kunita, K.
1979
Res, J.
Datles, D.J.
1979
Szokolay. A.
Dhnak, J.
Radarlc. 1.
1977
Carrie, 1.1.
Kadis. V.I.
Breltkreitz. I.E.
Cnnninghas, G.B.
Brans, G.I.
1979
-------
CTcloaaxane. 1,a,3,»,5,6-h«*«cb,loEo-. beta- (8 CI) ,,..,,.. .<. .•».
CTClohnaa*' 112^3'%.5.6-h.iKhloro-. <1alpaa.2beta.3alpaa.«beta.Salpha.6b«ta|- (9 Cl)
319-85-7
C6-H6-C16
Bt 290.83. BP 31«-31S C (aubliaa*). BP 60 C at 0.58 mm 89. TP 0.005 » 89 at 20 C
(COITIIOBD)
TISSOE
2063
Bilk, fat
EXPOSOBB BOOTS
kElLRXClL
BETHOO
OC-BC
BOBBEI
OF C1SES
al 3«
b) 6
BIE8B
-
a) 0.08-1.69 ppa
b) 0.11-0.75 ppa
BEIB
a) 0.53 ppa
b) 0.270 ppa
GEIBBIL IBPOBBITIOB
a) 81ga paatlcite usage acea
t) Lou pesticide usage acea
loaan living In Stacktllle,
Blaalaalppi (Ion pesticide aaaga) and
Delta acea (high pesticide uiage).
Saaplea la 1973-1975.
BILK; PESTICIDES; DDE; ODD; IDT;
fllllCBLOBOCTCLORIXlBE; HEfTlCBLOK
IFOXIDE; OIICB10ED1IE; DIELDFII;
MISSISSIPPI: COBPtBtTITE ETtlOtTIOBS;
HltSDREIIEBT BETBODS
BEPEBEBCE
Bacnett, B.I.
D'Brcole, ».J.
tcthac, B.D.
1979
-------
- <- «,
319-86-fl
Sn'o"', HI K1. 5-U2.0 C. BP 60 C at 0.3H •• Hg. If 0.02 » Hg at 20 C
trssBB
20(1
naipos*
06S
ilk
066
EXPOSURE ROOTS
mlLTTIClL
HWHOD
SC
ILC
BOB9EB
OF C4SES
266
3D
PIKGE
Mot qlTOD
0.3-3.2 ppb
<
lot qi»en
ICkH
0.011 «gAg. Valoe
Ls ledian.
1. 14 ppb
0.10 «9/kq
GE«fB»L iironntTiai
Subcatan«oaa ventral fat fro* the
Institutes foe Pathological taatoav
and rocensic Beaicine, 1171- 19T3.
PISTICIDES; Illtl!; PITS;
CIECHOSlOflKTU;
H!HCHtOBOCICI.OHII»llt: OOT; COE;
BIIftCHLORODCIIZEIIE
nilk saaples, hospitals in uiban
taller 1° southern Hocvny. lo
HLK; BBEAST; IKSECTICIOES :
LACTiTIOH; CHLOBI HATED HTDROCARBOMS ;
CBLORIIE OBGAHI- COflPOODDS;
EISTICIDES; I0881T
65 saiples-eacb is average fcoa 20
in Slovakia, 1971-1973. Values
PISTICIDES; BILK; fATS;
CfECHOSLOVAKIA;
HIIACRLOROCICLOHEItKE; DDT; CDE;
HEMCRLOBOBEIZENE
RErEREHCE
Szokolay, A.
Posival, I-
Ohnak, J.
nadaric, A.
1977
Bakken, t.r.
Seip, n.
1976
Szokolay, A.
Ohnak, J.
1977
oo
-------
Cyclohexane. 1,2,3.«,5,6-he«achloro-, gana- (8 CI)
Cyclohetane. 1.2.3.«,S.6-lieiachloro-. (1alpha,2alpha,3beta,Salpha,5alpha,6beta) - (9 CI)
56-89-9
C6-B6-C16
Rl 290.85. at galia-lsoier crystal* 112.5 C. BP 323.» c. 176.2 c it 10 •• Bg, IP O.M •• Rg at «0 c
TISSUE
2067
Adipose
2068
adipose
Adipose
2070
2071
EIPOJOBB ROOTI
Inhalation
aiiLnicu.
HETBOD
OC-EC
cc
GC
GC
GC
IOHBBB
or cists
at 26
b) 22
c) 27
d) 18
a) 18
» 13
168
a) 33
b) 17
23
BA»GB
a) <0. 001-0. 0777 ppi
b) 0.0016-0.1090 ppa
c) 0.0010-1.2876 pp«
d) <0. 0001-0.0400 ppi
•) <0. 0001-0. 0616 ppi
{) 0.0010-0.5799 ppi
0.001-0.136 uq/9
a) Not given
) 9
O.U5-15 ppb
(KBIT
mi
a) 0.0130 ppi
b) 0.0198 ppi
c| 0.0735 ppi
d) 0.0168 ppi
e) 0.01*5 ppi
f) 0.0881 ppi
0.007 99/9
is ledian.
a) 0.01 ppi
PPi
H.01 ppb
1
1
PUG El
GEIIBAL IIPOBR1TION
a) dales - stillborn
b) Bales - 0-11 10
c) Hales - 70* yr
d) Feiales - stillborn
e) Fesalee - 0-11 10
() resales - 70+ yr. Data available
{or intersediate age groups.
autopsy specimens, 1967-1971, frol
Israelis with no known occupational
eiposare.
IESTICIDES: IISECTICIDES; CRIOBIRE
CCGIIIC COKEOOROS; DDT: DDE; DDD;
DIILDBII; HBPTICBLCB BPOZIDB; 1DIPOSE
1ISSOE; ISBIIL; BEHCHLOROCrCLOHEUHE
Canadians froi Eastern Canada (16) f
Cnebec (501 , Ontario (57) , central
Canada (22) and Hestecn Canada (27) ,
1972.
PESTICIDES; CHIOBUE OIG1HIC
caapooHDS; DCT: CIILDBII;
EOLTCaLOBIBiTED BIPREDTLS; DIE; ODD;
•CtaCBLOB; BtlACHLOROCTCLOHBIKB;
OITCBLOBDtll; REPTaCBLOB EPOIIDB;
tCIPOSE TISSUE; ClIUDU
Institutes (or Pathological Inatoiy
and Forensic nedlcine, 1971-1973.
FISTICIDES: niLK; UTS;
CZECHOSLOVAKIA
BtlKCBLOBOCTCLOHIItHE; DDT: IDE;
HIItCHlOROBENZENE
a) Greenlanders, 20-75 yr old.
laparotoiies
b) Danes, 1-75 yc old, suddec death
by suicide oc in auto accidents
Median values, based on lipid vt
ADIPOSE TISSOB; AGE; AUTOPSIES;
CBI.OBIHE ORGANIC CCflPOUNDS;
PESTICIDES; ODD; DCT; DBF; DIEIDPIN:
H1PT1CHLOF EPOIIDE; POLTCHLOCINATED
ETPHBNTLS; COHPABATIVE BVALO ATTONS ;
POPOLATION EIPOSDBE; CBEENIAUD ;
DEBKABK
1^75 Yugoslavia survey, 121 saaples
serua or plasia .
yr (vean ag« <42 yr) In Croatia.
HIXACRLOBOCTCLOREIAIIE; DDE; CDD; DDT;
FfSTICIDES; BLOOD SEROH; DLOCD
ELISBI; TUGOSLAVIA; CHLOPINMED
HIDTOCABBOHS
BEFEBEBCE
(asseriann, H.
Toiatls. L.
Rasseriann, D.
Day, R.E.
Groner, T.
Laxarovici, s.
BosenCeld, D.
197«
Hes, J .
Caipbell, D.s.
Bobinson, B.N.
Davles, D.J.A.
1977
Bosival, L.
Ohnak. J.
Hadaric, A.
1977
Jensen, G.E.
197"
Peiner, E.
stipcetic, n.
Stefanac, 1.
VO
-------
Cyelohesan*. 1,2,3.*,5,6-haxachloro-, gaana- (° CD
Cyclohexane. 1.2.3,*.5,6-he(achloro-, (1alpha,2alpha,3beta,«alpha,5alpha,6beta) - 19 CI)
C6-R6-C1S
!» J90."5. BP gaaaa-lsoaei: crystals 112.5 C. BP 323. » c. 176.2 c at 10 aa Hg, TP 0.1» mm Kg at «0 c
(COITIROED)
TISSOB
2072
Blood
2073
Blood.
plasaa
207»
Blood.
seras
2075
Blood.
•hole
BXPOSOBE SOTJTE
-
„_
Dersal
AltLYTICAL
BETBOD
OC
OC
OC-EC
GC
BOB BSE
Or CASES
a) 11
b| »97
29
a) 11
b| 1
20
RUSE
a) 1-17 ppb
b) lot given
lot given
a) 7-23 ppb
b) lot applicable
a) 0.005-0.038 «g/al
b) 0.013-0.039 09/1!
c) 0.001-0.021 ug/al
d) 0.001-0.017 ag/al
•I 0.007-0. 06« ag/al
f) 0.002-0.008 og/al
(KIT
mi
a) 3 ppb
b) < 1 ppb
.
0.01*7 ppa
a) 16.8 ppb
b) 5.0 ppb
a) 0.013 a9/«l
b) 0.028 ag/al
e) 0.006 ag/al
d) 0.007 og/al
•I 0.02* ag/al
t) 0.005 ag/al
PISE)
GEItBIL IiroaiATIOl
a) Saaplea In xhich lindao* tarn
poaltlfelj ldmtltl«d
t) til Saaplts
Pcataortaaa. Tlrglcla State Bed leal
tiaalneca office, 1972. About «5S
fcoa vaite aalea. 30f fcoi black
aales, 15X fcoa vhite feaalei. 10%
fcoa black feaalea.
CBLOBIIE OBG1IIC COBPOOIDS; COT; DDE;
CIELDII1; TIBOIIIA; BLOOD;
FISTICIDSS; POLTCR10BIIITED
IIPHEITLS; BmCBLCBOCTCLOBEHIE;
BtFTkCBLOl IPOXIDE; CBtORIHTED
B1CBOC1IBOIS
nlghec paccantagea of ocqaaochloclae
insectlcldea and PCB'a ill ailk of
aatheca 20-29 yeaca than 30-39,
althoaga the foceec had lovec levels
in plasaa. ovecveight «oaeo had
Icnac levels than nosei of nccsal
(eight, lesldaes concentcated in
attracted llpids of plasaa and silk.
Iscaeli voaen 2-» days after Boreal
delivery.
PISTICIDIS; BLOOD PLtSBl; DI1K;
POPOLHIOI IIPOSOIE; ISBAEL;
CBtOIIHTED BTDBOCUBOIS; LIIXDS;
ME: DOT; OCO; DDE; POlTCUOIIIaTEO
BIPBEITLS; aiWlCHlOB EPOSID1;
BIItCBLOIOCTCLOBIItlE
a) Bale*, hogseholda with one or aora
aecbecs in pesticide indoatcj
t| resales, hoaseholds Kith cae or
eoce aaabecs in pesticide indastry
Boasehold doat levels 1.54-13.72 pps.
lesldents of leld Coonty, CO.
PESTICIDES; DDT; ODE; LIID1II;
BtPTaCBtOI EPOIIDB; CBLOBIIE OI01IIC
COBPOOIDS; DIELDIH; BLOOD SIB0B;
CCLOItOO; DOST; BEIlCHUIOCTCLOraXalE
a) 2 br-12 infected children
t( 6 he- 12 infected chlldcen-peak
c) «8 he- 12 Infected children
d) 2 hr-B nonlnfected chlldc«n
e) 6 hc-a noninf acted children-peak
t) *B hr-B noninfected children
Children age* 5-99 nonths infected
«ith scabies, and controls, in
Dallas, TX.
PtSTICIDES; CBLOIIHTBD BTDBCCUBOIS;
CILOIIIE oietnc COBPOOIDS; IBISEIIS;
BtOOD; CBI1DBE1; DISUSES:
COBPIHTIVB niLOaTIOIS; TEXIS
RErEBERCe
Griffith, T. D. , Jr.
Blanke. R.T.
1975
Poliahak. Z.n.
Bon, B.
Vassecaann, n.
Cocoa, 5.
Hassecsann, D.
Leaesch, C.
1977
Stare. B.C.. Jr.
lldrlch, r.D.
BcDoagall, v.D.
Boance, l.B.
197*
Ginsberg. C.B.
lo«y, ".
lelsch, J.s.
1977
-------
Cycloaexane, 1.2.3,l,5,C-hexacliloro-, aaiaa- (8 CI)
Cjclohesnno. 1.2.3,«.S.6-heiachloro-. (1alpha,2alpha,3beta.aalpka.5alpha.«b.E.
Cnnnlaghaa, G. B.
Brans, 6.B.
1979
-------
cyelohe
cyclohe
, 5,6-h«iachloto-, gaina- (9 CI)
,S,«-hex*chloro-, (lalpha, 2alphs.3bata,(alpha. 5alpha,6beta|- (9 CI)
C6-H6-C16
9V 290. as, »t gassa-lsoser crystals 112. 5 c, tt 323. « C, n«.2 c at 10 •• 89. TP O.la n Rg at »1 c
(CORTIIOED)
TISSUE
2001
911k, fat
2062
Orlne
EIPOSOBE ROOTB
Inaction
Dersal
kllLTTICll
RETROD
GC-EC
BadiOBVttrr
•08BBB
or c«s»s
al 30
b| 6
6
ik»GE
a) 0-0. 29 pp«
b) 0-0.03 ppa
a) lot given
b) lot glT«n
a) 0.03 ppa
bl 0.008 ppa
•) 2«.6
b| 9.3*
GtlEBU. IirORBlTIOl
•I High pesticide oiage acei
b) Lou pesticide usage area
Soien ll*lng In StarkTllle,
Illaslsslppl (lov pesticide usage) and
Delta area (high psstlclde usage).
Sasples In 1973-191S.
BILK; PESTICIDES: ODE; DDD: COT:
RIItCBlOBOCTCtOBnilE; REPTICHLOB
EfOZIDE: OITCBLOIDME; DIEIDHI;
IISSISSIPPI; COHPtMTITE ET1101TIOIS;
RltSOIEREIT HETRODS
a) IT dose of 1 ucl
b) Topical adainlatratlon of 1-5 oCi
Percentage oC dose excreted In 120
br. Data In b) corrected tot
Incosplete recover; based on data In
8«»lthy voluoteers*
ftSTTCIDES; gEBEICIDBS;
OtGlfOPBOSPRlTES; CRLOBIIS OBC11IC
CCHPOORDS; OBIIE;
I RIIICRIOIOCTCLORITIRI
Bacnett, B.«.
D'Ercole, Jt.J.
Cain, J.O.
Irthar, B.C.
1979
reldeann, B.J.
Balbach, B.I.
197a
NJ
-------
CJclohManol. 1-«thr«yl-, catfeaut*
12C-52-3
C9-H13-M-02
II 167.20. If 96-98 C. »P at 3 H Rg 118-122 C
TissDB
2083
Blood.
plana
Biposon loon
Xng««tioa
tlURICil
BBTBOD
OC
.
•1
OF
•1
bl
c)
d|
•)
n
6
JBBBl
CiSBS
BaKI
*) 6.«6-O.Oe ug/ml
b) 3.80-0.11 09/1!
c) 7.76-0.16 ag/ll
A) 7.3»-0.17 Q9/«l
•) 6.«2-0.53 ag/il
f) «.«7-0.31 09/1!
g) 3.86-0.06 ig/mi
k) 11.7«-0.25 Q9/I1
BBH
•) lot applicabl*
b) lot «pplic»bl«
e) lot «ppllc»bl«
4) lot tppllcibl*
•) lot cppllcibl*
f) lot «ppllc«bl«
9) lot applictbl*
h) lot *ppllc*bl«
OBI1UL XirOIBlTIOB
•) P««k !•*•! to !•*•! «t 15 he
b) P«*k !•*•! to !•»•! it 15 he
c| P««k UT«I to l«f«l at IS hr
a) p««k !•»•! to !•»•! it 15 hr
•| Mtk !•»•! to !•»•! at IS hr
f) P«ak l«i«l to 1««1 at IS hr
9) Mak !•(•! to !•»•! at IS hr
h) P«ak l«r«l to 1«»«1 at 15 hr
iBtlvUaala r*c*iT«d alngl*
thtrapcatlc doM* ef 1 9.
Bvalthf >al« Tol«nt««r«
BIOOD; BLOOD PLISBI; DiOGSj CBOG
TBEB1PT
nrauicB
Clifford. J.B.
Cookton, J.B.
liekkaa, P.B.
19T«
oo
-------
Cyclopropylaala*. 2-phaByl-, trana-(»-)- (6 Ct)
CyclopcopaaaalB*, 2-pheayl-, traca-l*-)- (4 CI)
155-09-9
C9-B11-I
81 133.19, Kt 164-166 C. BP 14-60 C at 1.5-1.6 •• Hg
TISSOE
2081
Blood
2085
Blood.
seraa
2086
Bra IB
2087
Line
-
2088
OrlBe
2089
Oriae
BIPOSORI ROUTE
iBgeatloa
lageatioa
IIILTTIC1L
RETROD
GC
OC-BC
GC
GC
GC
OC-IC
ROBBER
or CBSES
i
2
1
1
1
1
Rot applicable
a) 32-B7 ng/Bl
b) 20-31 ag/Bl
e| 7-12 ng/al
d) 6-10 ng/al
lot applicable
Rot applicable
lot applicable
al lot applicable
b| lot applicable
c) lot applicable
d) lot applicable
HR»I
3.7 ag/Bl
a) BO ag/Bl
b) 28 ng/Bl
c) 10 ng/Bl
d) 8 ag/al
1.0 ag/g
7.3 ag/g
25 ag/al
a) 0.35 eg/Bin
bl 0.70 ag/aln
c) 0.3* ng/aiB
d| 0.05 og/aln
gtlEHL IirOIBITIOR
ratal overdoM fcoa traaylcycroaiBe,
d-broaphanlraaine, d-inephedriBe,
tropoxyphoae, alcohol.
55 re old nhite feaale.
IICOROIS; IIICOTICS; DIOGS; BLOOD;
OIIIE; Bllll; LITII; BlTIDEPIESSITE
larns; CISB IISTOIIES; COIIKTICOT;
BROG IBOSE
i) 1 hr
b) 2. hr
c) 5 hr
dl 2« hr
Profile foe tiaea after 30 eg dose.
DIOGS: tRTIDEPRBSSITB 10EITS; BLOOD
SBBOB; OIIRI; BBISOIBBBII IB1BOOS
ratal orardoae froa traaylcyrroaiae,
d-broapheairaalne, d-laoephedrlaa,
[ropoiyphene, alcohol.
55 ye old (kite feaale.
ILCOROLS; IIICOTXCS; DRUGS; ELOOD;
OIIRR; Bllll; LITIR; linDIPIBSSITI
•OBITS; COIIICTXCOT; OIOG IBOSB; CASE
RISTORIBS
ratal orerdoae froi tranylcycroalae,
d-broaphenlraaine, d-iaoephedriae,
propoxyphene, alcohol.
55 ye old vhite feaale.
IICOROLS; RIICOTICS; DIOGS; BLOOD;
OIIIB: anil; LiTBi: tiTiDipnssiri
I6BITS; COIIICTXCOT; DIOG IBOSE; CISB
BISTOBIBS
ratal oraedoM froa traBylcyproaiae,
d-broaphenlraaiae, d-looephedrlBa,
[ropoiyphene, alcohol.
55 ye old *hite feaale.
ItCOBOLS; ItKOTXCS; DIOGS: ELOOD;
OIIIB; Bllll; LXTII; 1ITIDBPII3SITB
kGIRTS; COIIBCTICOI; OIOG IBOSE; CISB
IIST01IBS
a) 1 he
bl « hr
cl 8 he
dl 1« he
Baan eiccetory rate lor OBaeUbolixed
drag at tieea after 30 eg doae.
75 kg adult (abject.
EIOGS; IITICIPIBSSITE aGERS; BLOOD
SBBOB; OIXRIt BEISOIEHEIT IIIRODS
lErEIEICE
BBMlt, B.C.
Shaakan, t.
Groaa, E. B.
1977
Baaelt. B.C.
Stenart, C.B.
shaakaa, B.
1977
BBMlt. I.C.
Shaakan, B.
Grow. E.B.
1977
,„..
BBMlt. I.C.
Shaakan, B.
Croaa, B.B.
1977
BBMlt, I.C.
ShaakaB, B.
Groaa, B. B.
1977
Baaelt, B.C.
Steiart, C.B.
shaakaa, B.
1977
-------
D-41WOM. 2-(<(l2-cU.oroatkrl)Bltco«ouiBO|carbOBTlUBlBO|-2-a«os7- (» CII
5B7B9-90-5
C9-B16-C1-I3-07
II 313.73
tISSBB
2090
Blood.
plBBBB
2091
Cerebroip
inal
fUU
BlfOSOIB IOOTI
IBJBCtloB
Injection
1I1LRIC1L
BETHOD
ColoriMtrT
...
ColoriaetcT
IOBBBI
or c*sn
•I i
b) i
2
UlflB
•) 10fB-*)-8I10(B-6)
eOlea/1
b) 10 (B-») -3.7(10 (B-6J
B0le*/l
•) lot giTen
b) lot glTU
BBaE
a) lot given
b) lot given
_
a) font detected
b) Ion* 4Bt«ct»4
eiaiBii inoiunoi
a) 0-60 Bio
E| 0-60 Bin
Pec botk patient*. 120 eg/eg a IT.
level* declined trleiponentlallv.
tati«ot« vltk adTaiead Mtutatic
cancer.
laa*aa and troaitlag. Hjalotoxicity
at 120 ag/«g a oc gcvatac.
TkcoibocytopcDia ultk 4oB*B gc«at«c
thin 120 ig/*g B
DlOflS; DB06 TRI4PT; BLOOD PlaSU;
cisntct or COLOBBII; PLIIELRS;
CBEBOTBEllPl! IRICOIOBBDOIBrXXU.
STSTBBt DISItSBSt SPIIaL FLO TO;
LtDKOCTTES; COBP1BUXTB BTILQaTIOIS
a) 30 Bin after IT
b| 3 kc aftac IT
Bon not apaclflvi). licit at
detection »aa 10(B-6) eolea/1.
Patleate ultk advanced Mtaatatlc
cancer.
laana ana loaltinq. BrelatczidtT
at 120 ag/eg a oc greater.
Tkroabocrtopenla «lth dooea greater
tkan 120 ag/«g a.
DlOaS) D10G TIBItPT; BLOOD PUSH;
OIS1BXCT Or COL0BBH; CBZSOTHEHtPtj
imCOLOBIDOIHBLUL SISTSB; tlSBlSBS;
SPIUL FLOID; COIPlltTITB ETILOaTIOIS
1BFBIBICB
Botk. D.
Tooley, p.
Snen, D.
Bacdoaald, J.
Sckeln. P.
1970
Botk. D.
looler, t.
Green. D.
Bacdonald, J.
Sckela. P.
1978
-------
D-StraptMine, O-3-aBlno-3-daoxy-alpba-0-glucopjranosTl-(1-*>-o-(S-aaino-6-d«o«y-alpha-D-glucoprrano»rl-(1-«|)-l(1| - (»-aalno-2-hjdro»r-l-oiobutjl)-2-daoijr-, (S) -
31517-78-5
C22-H*J-«5-013
II 585.62, IF 203-20* C (•••ga.lhrdrata)
TtSSDE
2092
Blood,
saraa
2093
Blood,
8«r*a
EXPOSURE 80 DTE
Injection
Injection
IRILTTICIL
RETROD
ttcroblologlcal
Ricrohlologlca 1
R01BSE
or cisEs
a) 10*
b) 9
5
BUGS
.
a) lot gltan
b) lot glran
a) 12.9-16.7 ag/il
b) 10.9-12.7 ag/il
a) 25.5 « or - 1.2
ig/il
b) 29.3 » or - «.1
ag/il
a) 1S.O ««/•!
b) 11.9 og/il
SIIEBIL IIFORItTIOI
a) (lean p»k, 500 ag in
t) (lean p«ak, 500 ag Tf
9* patUats, 19-65 re, io(«ct*il olth
ailkacln-Masttiv* pathogens.
lotlblotlc «ff«ctl«n«a»: tctal-"Sf
c»*a, pactlal-3%, Ineff«cti»«-12*.
Banal and cranial n«c»« effvcti in 2
casa>. 1 eaa« of tcanilut axoteala.
DBOGS; OHOO TRER1PI; «DOLTS;
IITIBIOTICS; IE« TOlK; 81000 SEROH:
HOPLtSnS; CEITBaL IEBTOOS ST5TEB
DISUSES; IIIECTIOI; IP1B01IOB
CORPOOIDS
a| p«ak a(t«t loading tos* of 3.33
ag/kg IT Cor 1 hr, then 1 agAg o»«r
3 he
t) staadf state attar loading dow of
3.33 ag/kg If foe 1 he, than 1 *g/kg
CMC 3 hr
Pharaacoklnatlc paraaatara of
aalkaeln and kanaaycln vlrtaallj
Idantlcal.
Baalthr adulta.
ICOLTS; 4BTIBIOTICS; BIOOD; BLOOD
SEBDH; D10G TRBRiPT
BEFEBEICE
rarchlona, L.I.
Chadzlk. G.B.
1978
Clark*. J.T.
Llbka. R.D.
Ragaaay, C.
Kicby, I.a.a.
197*
-------
D-StraptaaiM. O-3-aBiao-3-4«oxy-alpha-D-glacopyranoayl- (1-6)-O-|6-aaino-6-daoiy~alpha-l>-glacopyranoB7l- (1-*)) -2-daoiy-
59-01-8
C18-I36-M-011
it aea.ss
TISSUE
209*
Blood.
plUM
2095
Blood.
aarna
BXF030BB lOOTI
Injection
Injactlon
inanxcii
BBTBOD
Blccoblologlcal
Microbiological
-
BOBBBB
or cis is
5
MBOB
•1 Bot applicable
b) Bot applicable
•) U.2-17.2 ag/al
b) 10.9-12.7 ng/nl
Bill
•1 5.0 ng/«l
b) 3.9 og/«l
a| 1S.B «g/il
b) 12.0 ag/il
CBIEUL IBFOIBHIOB
•) Start of «ch*Dg« tran*failo«,
10.5 hr «ft«r 8.23 ig/kg IB
t| lad of •xchang* tnufaalca
135 «lo fro* baglaaiag to «nd of
••Chang*
falau cittiatod froi graph.
2.3* kg. * day old *ho and«r«nt
•ichaag* tranafialon foe
hTpatbllliablDaala.
CBOOS; DBOG IHBIIPI; 4IIIBIOIICS;
IIFMTS; IBieOBI; BIOOD PL1SEI;
BRlBOlISB; TBXtS
a) Mak after loading dos* of 3.33
ag/kg IV for 1 he. then 1 ag/kg o»«r
3 he
b) Stoady state aftoc loading doaa of
3.33 ag/kg IV foe 1 hr. than 1 ag/kg
ciar 3 hr
Pharaaeoklnatlc p«raa«tara of
aalkacln and kaaaajcin *irtaallr
Idantlcal.
Baalthy adalta.
lEOtTS; IBTIBIOTICS; BLOOD; BLOOD
SITOB; OBOG TBCIIPT
BBTBUBCB
lakataa. G.J.
Silth, B.B.
L«ff, B.D.
Kay. J.L.
1978
Clark*. J.T.
Llbka, R.D.
Bagaaoy, c.
Klrby. l.B.a.
197»
-------
Dt3iethrl4os«pln (to posting! ID CftEHLIRE).
TISSUE
2096
Blood.
plcmt
EXFOSORE ROUTE
IRURICU
4BTROD
also
•••mrad.
tRTIOBPRESSITE tCRRS; DROSS; BLOOD
PUSH*; REISOISRER1 BBTHODS
RBFEREICE
J«nkln«, U.S.
frl«d«l, R.o.
1978
00
-------
Dib»x(b.*)onpiD-d«lt*(11(«B) ,«»••» -propylMln*. «-««tkyl-, kydrocklortda (8 CI)
roptuiiM, 3-dlbm«|b,«)ompln-11(6R)-nii«B*-l-nthrl-. hj4rochlori.il* (9 CI|
7-91-«
2«S7-
II 301
Txssm
2097
Blood.
plan*
BIPOSIU KOOTB
I>9««tto*
IBltRICtL
BBTBOO
8C/BS
BOBBBt
OP GUIS
7
UBOB
«.e-u.s B9/ii
BBIB
9.7 og/»l
emui. iiroiainoi
Pclloilig oral do«« of 75 mg donpia
kydrocklorldi. P««k Icnla 2-10 kr
•Ctec adBlBictotioB*
7 Tolnntcvri, 26-36 yr.
DIDSS; BLOOD PLtSBt; IRIBOIRBS;
tlTIDBPIESSITB ISIIIS
Ucglcr, f. B.
Btm>, J.T.
lylt«. L.T.
BOMB, 5. a.
B«vf. D.J.
Corrcll, v.B.
1978
•vj
\0
-------
OlbenxO>>e)otepiQ-deUa(11(6B).gaBaa)-proprl*Bino. 1,1-diaethrl- (8 CI)
1-ProBaaaiine, 3-dlb*nx(b.a)c»pln-11 (6B)-yUd«n*-l,l-dlMthyl- (9 CI)
1668-19-5
C19-H21-I-0
81 219.3"'. BP 15»-157 c at 0.03 •• If. 260-270 C at 0.2 » 84
TISSUE
2098
Blood
2099
Blood.
plaaaa
2100
Blood.
plaaaa
2101
Blood.
plan*
2102
laact
2103
lint
EXPOSQBB ROUTE
_
Ingest ion
Xngaatlon
Ingeation
Ingeation
Ingeation
kllLYTICtL
RETROD
GC
ac
_^
OC/BS
GC/HS
GC
ac
HOUSES
or CISES
10
tt 1
b) 1
c) 1
dl 1
s
^
10
10
.
WIGS
lot detected-1*.* ag/al
a) lot given
b) Hot givm
c) lot given
d) lot given
. .. . - ...
n-122 ng/al
8.8-«7. t ng/al
lot datected-109.0 ag/g
2. 6- 257. 0 ug/g
1E»I
lot given
a) 29.* ag/il
b) 30.2 ng/el
c) 38.* ng/al
d) 239.1 ng/al
5B ng/al
26. 1 ng/al
lot given
lot gl»««
GEltltl liFOBllTIOl
10 of 29 caaos.
Tcicrclic «ntia«pc«s««nt o«tdo«*
(«taliti«> (froa 961 >aap«ctad drag
afcas* casaa invvatigatad in £aa
Di«go. C*. Jan-Oct 1978) .
EIOSS; tITTDEFRESSITE tQEITS; DBOG
HOSE; BbooD: lifts; RUBT:
ciLiroini
a) 100 mg dally
b) 100 ag dally
c) 100 ag dally
d| 100 ag daily
9-10 aaaplaa aack caae
Talnaa aca total trlcyclic aiirxi.
Ontpatlanta tcvatad foe dapraaalon.
CIUOS; alTIDIPBESSITE 40EITS ;
tSTCBOTIOPIC DIOOS; HET1BOLI1ES;
HOOD PLISSI; OIRID STiTES
C«ti«nta being treated »ith 15-300
ag/day doiepin. letabolite
deaaethyldosapln lavela alao
aaaaaced.
IHIOBPBESSTTE ICEITS: DBOGS; BLOOD
Pt«SB»: MMSOIEBEIT BBT80DS
fcllonlng ocal doae of 75 ag dompin
kydrochloilde. Peak value* 2-« he
after doae.
7 volunteara, 26-36 yr.
DIDOS: BLOOD PltSII) RBTkBOLRSS;
IITIDWKSSIfE ICE ITS
10 of 29 caaes.
Iticycllc antidapceaaant OTeidoae
fatalltiea (fcoa 961 mapected drag
ataae caaaa inveatlgated in San
Diego. Ck, Jn-Oct 1978).
CIOQS: kITIDEPIBSSITB »OEITS; DBOG
1EOSB! BIOOC; LXTIli BB11T;
CUIPOIIIl
10 of 29 caaea.
Ttlcyclic antideprcaaant ovecdoae
fatalities (fcoa 961 a«apect«d drag
abaae caaaa inveatigated la San
Clego. CI. Jan-Oct 1978}.
CMOS; IITIDEPBESSIfB aOERS; DBOG
tBOSE; BLOOD: LITEB; BUST;
CUXPOEII1
BEFEREICE
Bailey, D.I.
Sbav, *.r.
1919
Zieglar, T.E.
lylie, L.T.
Bigga. J.T.
1978
Jenkina, E.G.
rriedel. i.o.
1978
Ziegler. T.E.
Bigga, J.T.
lylle. L.T.
Voaen, S.B.
B««f, D.J.
Coryall, i.B.
1978
Bailey. D.I.
Ska*. B.P.
1979
Bailer. D.I.
Ska*. I.P.
1979
oo
o
-------
tlbms (b. f) (I, «) ox»*pla-8-ol, 2-chloro-11- (1-pip«r»lnrl) -
61M3-18-S
C17-B16-C1-I3-02
Bl 329.81
TISSDB
210«
Blood.
BXPOSVIB BOOT!
injection
ingtfttioB
iiunzcai
IRBOD
OC-BC
•OBBBB
OP CftSBS
10
iiioi "~
a) lot glvw
b) lot 9i»«n
e| lot glv«
8BII
•1 ia.2 n9/»l
b) 8.2 B9/«l
e) 2».3 ng/al
^,
OEIEBkl IIFOBBITIOI
•) Daf 8. nan doaag* 29.5 19. IT
IB
b) Dar 8, Man doiag* 29.5 19. oral
c) 10 *k, ••« do«a9« 92.0 ag, oral
10 aala ko
-------
Clb*n«(b,f) (1.«)o»npln-8-ol. 2-chloro-11-<
6H«-77-«
C1B-BH-C1-I3-O2
KB 3»3.1»
-••*byl-1-plp«t«tinyl)-
ITSSttB
210S
Blood,
pltaaa
IZPOSORS BOOTS
. . . _ .
Injactlon
Ing* at lea
UaLTTICll
BETHOD
OC-BC
u _
»OHBB8
or cisss
10
BtlOE
•t lot 9lT*n
b) lot qi»«n
c) lot 9l**n
HEtl
a) 33.8 n9/al
b) 29.6 ag/tl
c) *7.7 ng/al
GEIIHL IIPORDITIOI
a) Oar 8, atin 29. 5 ig. IT
IB
t| Dar B, a«an 29. 5 ag, oral
c) 10 »k, a«an 92.0 ag, oral
10 aal* hoapltalixtd chronic
acktxophrcalc patl«nta, a*an ag« 39.9
rr (rang* 22.6-50.6 fr) .
CR035: BLOOD PlaSBa: COHPaBallTB
CTaLOITIOIS: CBITBIL BSRTOOS SISTBH
DISBiSES
1EFEBBICE
Slapaon, G.B.
Coop*r, T. B.
L*e, J.B.
Tonng, n.l.
1978
00
-------
Dib*Bt(b.f) |1.«)oiaz*plM. 2-chloEo-11-(»-«*thyl-1-plp«r*«Uyl)-
1977-10-2
C18-B18-C1-I3-0
II 327.81. BP 109-110 C
TISSUE
2106
Blood.
plan*
2107
Blood.
plasaa
2108
Dries
BXPOSOI! 100IB
lajsctloa
lag* at ion
Tagsstloa
Xagcstloa
1I1LYTIC1L
BBTBOO
OC-BC
6C
OC
BOHBES
or CISBS
•1 7
b) 5
5
_ ..
5
BIIGB
a) lot givsa
b) lot glT*a
c) lot gl»«n
4) lot 9lT«n
•) lot glT*n
•) 1-20 ag/sl
b) 0-2.8 ng/sl
a) 1.25-30.8 ng/sl
b| lot d*t«ct*d-«.3 ng/il
IBM
a) 19.9 ng/sl
b) 25.2 ng/sl
c) 29.0 ag/sl
4) 3.2 og/il
•1 11.0 ng/«l
t) lot gl**a
b) lot gi*«n
i) lot glno
bl lot glT*n
8IIII1L IIPORBtnOI
•) 1 hr »ft«r 30 ig IS
b) 1 he »ft«r 30 «g or«l
c) 0*f 8, i«n do»9< 29.5 19. II
d) My 8. i«u do<«9* 29.5 19. oral
•| 10 «k, ••» do«*g« 92.0 •?, or«l
10 Hi* ko«pit*llx«d chronic
•chlxophcvBlc patlmti, B««B «g» 39.9
yt (rang* 22.6-50.6 fr).
DIOOS) BLOOD PUSH: COBPtlinTB
MUOlTIOIS; CBITIIl IIITOOS STSTBB
DISUSES
>) lB>g« of p»k« (0-» BE after last
IOM) for patl«Bt« aft«r 80 ig/dar
foe 12 Ik
b) individual Taliu 12 hr a«t«r last
dOM
Istisatod fro* graph
lid* Tariatioa aaoag s«bj*cta.
Bospitalind. non-«ckixopkr*nic.
psychotic pati*Bts. 28-19 jr old,
56-91.5 kg. IB good physical h*alth.
DIOOS; DRUG TRBBlPT; PSTCBOTBOPIC
DIOOS; BLOOD PLiSBii OBIIE;
BltSOIEHBIT IETBOD5; CMiDI
a) Bang* of psaks (0-8 he at t*c last
do**) Coc pati*nta after 80 ig/day
for 12 «k
t) IndlTldaal »«lu«» 12 hr aft*r last
dcs*
3 Mtabolltas id*atifi*d by oc/HS.
Rospltallud. non-*chisophr«Blc.
psychotic pativata. 28-19 yr old,
56-91.5 kg. la good physical hsalth.
DIOOS; DBOG TREIlPT; PSTCHOTB3PIC
DlOaS; BLOOD PLlSBt; OBIIZ;
IIISOIBIBBT BBTBOD3; CtlkDl
UFE1EICE
SispSOB, 6. B.
Coap*r, T.B.
L«, J.B.
Toang. B.t.
1978
Coop*r, S.T.
Dugal. B.
Bsrtraad. B.J.
1979
Cooper. s.F.
Dogal. B.
B*rtrand. S.J.
1979
00
OJ
-------
*. kmcklen-
€»-«*-«*-«
Z3*-2M C «t • m
21M
line
(WKI
ar cus
tio* all.
at ICB
:ti=i«i: ctanms; tool
-crrttiiiTiti: LIiD: uirosi nss»»;
JMU
(•cakl, 1.
. I.
ccmrmnci; inn: ua«si nss^t:
-------
CUB
cnnu. nrmmxau
2111
rtctiM of PCI palBCBlat *!•
ccvnttMtxov; uw; umost
2112
< •.«•»-•>. 1
«. T.
JIM!
urn; uznn
-------
Olb*nxofur*a. 2,3, «,•>, 8-p«nt»chloco-
"
C12-H3-C15-0
HI 330
TISSOB
2113
Idlpos*
211«
llTVC
EIPOSUBB BOOTS
IngMtlan
Ing«*tloD
1BU.TTICIL
HETBOD
.
cc
ac
cr
cc
POBBM
Of CISBS
S
5
HKE
< 0.005-5.7 ppb
< 0.005-6.9 ppb
HSU
lot gl»«n
lot gl?«n
GEIEBtl IBFOBBITIOB
J«pan*a< »icti«« o( PCD poiccnliig Tit
clc* oil.
CB10BIIB OB01BIC CCBPOOUDS; IOOD
CCITIHIBITIOI; I IT IB; tDIPOSI TISSUE;
JIFIB
Jipanen tictlis at PCB polncnlnj »1«
cic« oil.
CBLOBIBB OB04BIC COBPOOIDS; IOOD
CCBHBIB1TIOB; IITEB: IDIPOSl TISSOE;
JlPtl
BEFEREICE
Xorokl, 8.
naaada, T.
1978
Karoki. fl.
BMada, T.
197S
•
00
-------
DibMtoCnran, 2,3.«.8-t«tr«cUoro-
57117-37-0
C12-M-C1«-0
•I 306
nss«i
211S
Uipon
2116
ll»»r
BIPOSTJ1B 100IE
Ing«*tion
Iigcrtioi
IIILTTICIL
RBTIOO
.
oc
DC
cc
oc
IOBBBI
OF CkSBS
s
5
UNI
< 0.005- 0. 6 ppb
-
< 0.005-0.7 ppt>
-
•«•
lot glT«n
lot ji»«n
aiinit znocuTioi
J«p»«M fietlis of KB polacnlig »i*
ric« oil.
CIIOIIIB OIS1IIC COIPODIDS; IOOD
ccRimttxait iifnt toxposi TDSOE;
jipti
J«pu««« *ictl» of KB pollening »i«
clc* oil.
cnoniB oieknc COIPODIOS; MOD
comaiiiTioi; inn; UIMSI iissos;
JIVII
nmnci
Iinki. I.
Bua
-------
DlbmsotHHii, 2,3, 7,*-t«tr«cbloro-
51207-31-9
C12-H»-C1«-0
«• 306
TISSUE
tdlpOK
211*
EIPOSOBE HOOTS
Infection
tuition
IBtLTTICU
HETHOD
_ ...
ex
oc
rr
oc
IOHBBR
or cists
5
5
B1BUE
< 0.005-0.3 ppb
< 0.005-0.3 ppb
HEIB
•ot 9iT*n
Bot gifon
GEBIB1L IirOBUlTIOl
Jlp«n«>* Tlctln of PCS pollening fit
tic* oil.
CBIOBIIE OB04BIC CCRPOOBDS; FOOD
COBIIBIBiTIOB; 1ITEB; tDIPOSI TISSUE;
Jlftl
Jlp«n*M tictli* of PCS pollening Tit
tic* oil.
C8LOBIIE OBCillC COBPOOBDS; FOOD
CCBT1BIBITIOB; LIfIB; tDIPOSI TISSOE;
JIPtB
SErERE»CE
Huron. B.
FJtBDdty T.
1978
Karofci, H.
Ktsadt , T .
1978
00
oo
-------
Card-20U2/-«olld., 3-
(3b«ta,5tMta)- (9 CXI
(3b«ta,5
C«1-I6I-013
» 76«.«2. 81 256-2S7 C (aahydrooal
TI3SDI
2119
Blood.
BltOSOBV BOUfB
I»j«CtiOl.
tllLTTICIL
•BTBOD
OC/BS
-
IUIBBI
or cisis
•» f
bl 7
iiioi
•) 7.0-31.0 ns/ll
b) 0. 6-16.7 B9/il
nit
t) 13.2 ag/il
b) C.T ag/il
fiiiiui iirotunoi
» ?*ti
-------
ClgoxlB CO CT|
Card-20(22)-eaolide,
(3beta.Sbeta.12beta)-
20830-75-5
C«1-B6«~01«
B« 7*0.42, UP aboat 26S C (dacosp)
Ct)
- (1-«) -0-2 ,6-dld«oiy-b«t«-D-rLbo-heioprr*noarl- (1-1) -2
-12,
TISSOE
2120
Blood,
fetal
2121
Blood.
plena
2122
Blood.
plesu
2123
Blood.
plasia
EIPOSOIE BOOT 8
IngestloB
Injection
tltLTTICU.
BETHOD
Bit
Bit
Bit
Hit
IOBBBB
or ctsBs
i
•) 7
b) 7
22
•
UBOE
. , .,
lot given
. . .
a) lot given
b) lot given
27-9S ng/il
a) lot given
b| lot given
nil
1.0 ag/sl
a) «.1 ag/il
b) 1.1 ag/il
lot glf*a
4) 1.0 ag/il
b) 0.36 Bj/Bl
CtllBll IIFOBItTIOl
l«»«l at tellTBtf. Bother treated
•1th 0.7J (g digozlB dally during
pc«qnaacy and after delivery.
30 yr old icther, (lest pregnancy
lo« aaternal mroi eatrlol levels
[re-dell*ery.
tlOOO SBBOD; BILK; OBBILIC1L COBD;
DIOSS; D«OG TBEBtPT; CtlDIOTISCOLtB
CISBaSBS; aOOLTS; IBIBOBI; PIBOItlCT;
I1CT1TIOI; C1I1D1; CIS I BIS1CBIBS
a) Congestive heart failure tatleBts,
peak, 1-3 hi after 0.75-1.0 eg
dlgozia
b) Coagestl>e heart failure ratlenta,
after « day* of dally dlgozlg.
Values froe graph.
STIBOIOS; DBOQS; BLOOD PL1SBI;
CIBDIOTISCOHB DISUSES; HEllT
CISEISES; OIITED KIIGOOB
Patients tilth ayocardial Infarction
complicated by left-»entrlcal«r
fallare, given 0.7S-1.0 ag digoxla at
0. 125-0. 750 ig/sln. Peak values.
lo eitracardlac syaptoas aad BO
conduction defects due to dlgoila.
SltBOIDS; B1000 PLaSBk; DBOOS;
CalDXOVaSCOLal DISUSES; BBaBT
OISBISES; SIEDEI
•) 0.25 lg digozin dally thrcaghoat
pcegaaney
b) 0.25 ag dlgozln • 80 sg
cropranolol dally for 10 yr
Olgoxln not detected IB Infants.
mo pregnant rasen taking digaxla.
one foe chronic rheasatlc cacdttls
and the otkec taking dlgoxla and
fropranolol for recurrent
tachycardia. Both infants (are tere
and had aoraal neonatal period.
DIOOS; SIlIi BIOOD PLaSBt; ttOLTS;
lift ITS; lOSTItLIl; DBOO TBIUPT
BEPEBEfCE
rinley, J.P.
•axBan. l.B.
long, P.r.
Lickrish, c.a.
1979
•hltiag. B.
saaner, D.J.
197«
Bertler, t.
Bergdahl, B.
Karlsson, B.
197*
Loughnan, p.B.
1978
(IBR PtOB)
-------
Digoxla (8 CI)
Card-20(22)-enolido, 3-((O-2.6-4ideoxj-beta-D-ribo-kexopycenosyl-{1-») -0-2.6-4ideoxr-b«ta-D-rlbo-kexopyranosyl-<1-«>-:.6-dideoxv-bata-l>-ribo-kexapyraaoayl)oxv)-12,1*-dihydroxy-
|3beta.5beta,12beta|- (9 CD
20630-75-5
C»t-B6»-01»
If 760.92. at «bo«t 265 C (decoap)
IcoirxraiD)
nssra
212*
Blood.
plasaa
2125
Blood.
•erne
2126
Blood.
secaa
2127
Blood.
•ecus
2128
Blood,
secaa
BirosniB BOOT.B
Injection
Injection
Ingest ion
1BILTTIC1L
BB1BOD
III
BI1
III
BI1
BT1
BOBBBB
OF C1SBS
al 16
b) »
6
2
1*
IB
11 BOB
a) 0.5-2.5 ng/al
b) 0.6-2.2 ng/al
a) Bot given
b) Bot given
c) Bot given
a) 2.6-2.1 ng/al
b) 0.6-0.2 ng/al
0.83-2. 15 ng/al
0.3-6.5 ng/al
(•BIT
BBtB
a) 1.03 ag/al
b) 1.07 ag/al
a) 2.07 ng/al
b) 0.28 ng/al
c) 0.16 ng/al
a) Bot given
b) Bot givaa
l.ia ng/al
2.5 ng/nl
PIT 8)
6BBII11 IBTOIB1TIOB
a) Boraokaleaic patients, treated
•itk dlgoiln, faroseaide. and
b) flypokalealc patients, treated »ith
digoxln, faroseaide,
kydrocklocotkltxlde, and potassina
•atiaat* receiving daily tceataent in
Copenkagen, Denaack koapital.
Bocaokalealc patient* (age 29-6* re)
•itk ckronlc congestive keart failare
doe to Bitcal stenosis aad aitcal
insufficiency. Bypokaleaic patients
•itk congestive keart fail«r«.
Bodecate hypokalaala cednced tke
active tabalac secretion of digoxln,
tkas increasing it* half-Ufa.
DBOBS; POT1SSIOH; BLOOD PL1SB1;
HOLTS; BBlIt DISUSES; DBBBIBK
a) 1 kc post-injection
b| 7 kc post-injection
e| 2* hr post-injection
Baalthy aalea ages 25-35 yr.
OlOGSj DtOIBTICS: BtOOD SBBOti OBI IB;
ICOLTS
a) Botkec. deliver} to 7 days aftec
b) Infant, delivery to 7 days of age
Bctkec treated eltfc 0.75 ag dlgoxin
daily daring pregnancy and aftec
delivery, aaabcane* artificially
raptured at *2 vk. lelation ef aacaa
levels to siall else of intact
conjectural. Sex o< infant net
stated.
30 yr old Bother, first pregnancy.
lo« aatcrnal seroa estciol levels
cre-dellvery.
BIOOO SBBOB: Bill; OBBILXC1I. COBD;
DIOGS; OBOG THII1PI; C1BDIOTISCDL1B
CISB1SBS; 1DDLTS; IBWBOBI; PIEOB1BCT;
LICT1TIOI; CIHDli MSI BISTOBIBS
•atleats on Mintacanca doses froa
0.125-0.25 eg/day
11 sales. 3 feaales aged 57-88 yr
scheduled to aadecgo acologic
•argical procedure*.
OBOGS; BBT11S; POT1SSIOB; BLCOD
SIBOB; SPIIll FLOID: DBOG TBIBUI
lotopay sasples
Eatlents aged 12-" 2 yc tceatid vitk
dlgoxin before deatk.
DIOGS; BLCOC PLlSBt; BBMT: BOSCLBS;
IOTOPSIES; IDOITS; CHILDBEI
IBTBUBCB
Steiness, B.
1978
Tsntsnel, B.
Fnjlki, B.
Takeda, B.
rakoskiaa, B.
1979
rlnley, J.p.
Vaxaan, I.B.
Bong. P.I.
tlckciak, G.B.
1979
Oayes. J.B
oreeablatt D. J.
Ho yd, B.I
Bareats, J s.
Seltb, T.I
1978
Biddle, T.L.
lelntraab, R.
Lasagne. I.
1978
-------
Cigoxin (8 ci)
Cacd-20(22|-enollde, 3-< (O-2,t-didaoiy-beta-D-rlbo-hexoprranosyl- (1-») -o-2,6-dldeoxy-bota-D-rlbo-hexopyranosyl-(1-« ) -;,6-dldeoxy-beta-D-ribo-hexcpyranosyl)oxy)-12, ia-dihydrozy-,
(3beta.5beta.12beta|- (9 CI)
20130-75-5
C«1-B6«-01«
II 7tO.°2. HI aboat 265 C (dacoap)
(COITXIOED)
TTSSOB
2124
Blood.
serae
2130
Hood,
•eran
2131
Blood,
•eran
BXPOS01E 100TB
Inject Ion
Ingest Ion
Ingestlon
ilkLTTIciL
•ETBOD
M»
lit
IOBBBB
OF C»SSS
•I 25
b| 12
1
a) 10
b) 6
c| 10
d| B
MICE
a) 1.«-7.5 ng/al
b) 1.2-3.0 ng/al
__
11-1.1 ng/nl
a) lot given
b) lot given
c) lot given
4) lot given
(int
8Ekl
a) 3.5 » or - 0.39
ng/nl
b) 1.73 » or - 0.15
og/il
lot applicable
a) 3. » » oc - 0.9
ng/al
bl 2.0 • or - 0.8
Bf/ll
c) 1.0 » oc - 0.3
ag/ll
d) 0.9 » or - O.H
•g/il
ptaq
GtltltL IIFOI8ATXOI
1) lft«c 30 og/kf, divided, u
loading and ialnt*nanca domi
b) »ft«c 20 09/k9. divided, as
loading and Hlntcnance dosei.
Fcado** iai[l*« 12 he after > or • «
•elnteannce doaea.
preaatura noborna »ith patent dactu
arterloala, cardlOMgalv.
bepatoeegalr.
C1BDIO?»SCOL»B DISB1SE3; IIFIITS;
ICIBOtl; DIOGSi DBDO THEBiPI; TEXaS;
BIOOO SEIOH; BEUT DISEkSES
7.5 and 67.S he after 18 eg. vith
•laoltaneooa charcoal heaoperf aalon
and elth heaodlalyala, reducing the
level froa 7 to 5. 5 ng/el In 5 hr.
[atlaated Ccoa graph.
(1-fr-old loaan. Ingeated 18 ng,
oniveraltv Boipltal, San Diego, ca.
lauaea. voiitlng, lethargj.
fefpoteaalon . ir regular pulse,
atcloventclcnlar block, "dlgitalla
effect", hyperkaleaia
DIOGS; D10G 1BOSB; BLOOD SEIOI;
CatirOllIt; IIIEMl EETlBOLXSIS
FCHSSIOB
al < 1 no of age, 0.02 » or - 0.005
ng/kg/dar
b) t-3 no of age. 0.016 » or - 0.006
as/kg/day
c) 3 ao-1 yr of age. 0.015 » or -
0.005 ag/kg/day
dl 1-2 re-olds. 0.013 * or - 0.00*
ag/kg/day.
patients ages 1 »k-2 yr, at the Chain
Sheba Bedlcal centec. Israel, atodled
froa the 3rd day of aalntanance
therapy.
Digitalis Intoxication in 3 cf 10
naonatea and one infant < 1 yr old.
all «ith sere* levels > 2 og/al.
tbnoraal ECS associated «ith cases of
digitalis Intoxication.
DIOGSi DIOS TIElaPI: HEalT DISBaSES;
iirtns; iBieoii: CRXLOIBI; ELOOO
SCIOI) >OB; ISIaEL
BEFEBEICE
Plnsky, I.I.
Jacobsen, J.B.
Gillette, P.c.
Idaas, J.
Honroe, L.
Hclanara, D.S.
1979
Barren, s.E.
Fanestll, 0.0.
1979
Balkin, a.
Eadossky, B.
Blieden. L.
Fcand, 1.
Hlllnan, p.
Boichls, B.
1978
v£>
-------
Digoxin (V CX)
Ctrd-20(22)-eaolila, 3-((O-2,6-dldeoxy-beta-0-cibo-»aiopyr*noayl- (1-»)-0-2.6-dl4eoiy-neta-D-rlbo-hexopyranoByl- (1-») -2,6-dUaoxy-bata-D-ribo-hexcpyranoayl.)oxy|-12.ia-dihydroxy-.
(3beta,5beta.12beta|- (9 CI)
20830-75-5
cai-B6«-01«
II 760.92. IE aboat 265 C (decaap)
fCOITIIOID)
TISSOI
2132
Hood.
Mcai
2133
Brain
213*
Cerebrocp
U«l
fl«id
2135
••act
2136
leart
IIPOSOIE BOOM
Injection
Ingest IOB
injection
klkLRICU
IBTBOD
nil
Hk
BIk
(Ik
IOIBBE
OF CISES
1
13
U
16
13
IklGE
a) tot given
b) lot given
•1 0-13 ng/g
b) 0-«1 ng/g
c) 98-183 ng/g
0.07-0." ng/»l
18-262 ng/g «et «
») 21-92 ng/g
b) *9-193 ng/g
c) 98-271 ng/g
(IER
mi
a) 2.2 ng/al
b) 0.* ng/il
a) 5.2 ng/g
b) 15.9 ng/g
e) 1**.2 ng/g
0.16 ng/il
911.2 ng ««t tit
•1 «9.6 ng/g
b) 1*6. « ng/g
c| 163 ng/g
P108I
amuL iiroiiHioi
•) on 0.25 ig/d*7 digozio
b| 3 dar« after diacoatinaatloa of
gainidin*. Ioeoipanl«d by advcn*
*}>Ftoa* c«col*«d by ioecaaalng
digoxin to 0.5 ig/day.
62-yc-old f«nal« vlth cong«ati»«
(•art failar* and chronic atcial
fibrillation coap«nMt*d 5 yt on 0.2S
•g/day digoxin and 300 ag *X/day
qaialdin*.
DIOG IITBBICTIOI; BLOOD SE10I; CIS!
BISTOIIBS; DI06S; DIOB TBEH1PI; B81BT
DISEiSBS ; BJltTH BUktOS
a) Ihit* aattw
t| oray aattar
c) Choroid pl«x*a
latopil**, 72-99 yr old*, on drug op
to 10 yr «lth last do5« 3-22 hr
t«for« d«ata.
Clllkll; DIDBS; DB06 TRBBkrT; BIkll;
BIkR; kOBi kDOLTS; BOSCLES;
kOTOPSIBS
Patiants on aaint«nanca doaai troa
0.125-0.25 ag/day
11 aalai, 3 f ••«!•• ag«d 57-88 yr
ach«dal«d to andvrgo arologic
aacgical proccdaraa.
DROOS; IITktS; POTkSStOB; BLCOD
SEIOI; Sfllkl TLDIE; DIOG TinkPT
kotopsy aaaplaa-laft rantricla, fat
caaovad
Catianta agad 12-92 jc traattd «lth
digoxin bafor* daata.
ClOOSi BLOOD PLkSHk; IlkBT; BOSCLB5;
kDTOPSIBS: kCOLTS; CBI1DBII
•) Laft atrina
b| light ventricle
c) Left ventricle
katopaiea, 72-99 yr olda« on dreg up
to 10 yr nith laat doae 3-22 he
before death.
CUBkBK; DBOOS; DEDG TRBBkPT; IBkll;
BUST; k9B: kDOLTS; BOSCLBS;
IOTOPSIBS
BEFBUICE
Roench, T.B.
1980
Krakaaer. B.
Steiaes*. B.
1978
oayea, J.H.
oreenblatt, O.J.
Lloyd. B.L.
Raraatx. J.s.
Saith, T.B.
1978
Biddle. T.L.
•eintranb, a.
Laaagna* L.
1978
Krakaaer. B.
Steineaa, E.
1978
SO
u>
-------
Clgoxin (8 CI)
Card-20(22)-enollde, 3- ((O-2.6-41d*oxy-bata-D-rlbo-heiopyranoiyl- (l-«) -0-2,6-dld*oxy-beta-D-rlbo-haxopyranoayl-(1-1 | -2,6-dU*oiy-beta-D-rlbo-hexopyranoayl)oxy)-12, 1»-dihydroxy-,
|3o*ta,Sbeta.12beta)- (9 CI)
20830-75-5
CI1-R6I-OU
Bl 180.92, IP about 265 c fdeconpt
(CORIIORD)
TISfDB
2137
Illk
2138
Bilk
2139
Buacle
BXFOSOM BOOT!
Injection
illLTTTClL
BBTROD
iii
Hi
HOUSES
OP CIS3S
1
2
13
BitSE
lot given
a) 0.6-0.96 ng/al
b) 0.28-0.61 ng/nl
. _
a) 0-28 ng/g
b) 0-«« ng/g
BEll
1.9 ng/nl
a) 0.78 ng/nl
b) 0. (1 ng/nl
a) 1«.2 ng/g
b) 29.8 ng/g
GdltlL IlfOBBlTIOl
tt««l 7 day poat pactaa. Patient
received 0.75 ng dlgoxln dally daclnq
pc«qn«ocr and after d«li»«ry.
30 yr old «caan, flcit pr«gn«ncy
leu laticntl aecaa «»triol l««la
eiooD SEioa; BILK; OBOILICU. coin;
OI08S; DIOG TBIRaPT; CJiDICTISCBUB
DISMSSSi (DOLTS; IIIBOH: FIBGIMCT:
LICTaTIOl: CtnDI; OS I BISTCIIBS
•) 0.25 19 digoxin dally thccagkoot
i( 0.2S mg digoxin » 82 19
pcoprtnolol dally (or 10 yr
Pragnant «oi«n taking dlgoxli, on*
(or chronic rhcuatlc cardltla and
tk« otkcr taking dlgoxln and
propranolol (or r«carr«nt
tackycardla. Both infant* "«r« tarn
and had noraal neonatal period.
C1DGS; BILK; BLOOD PLtSBl; itOLTS;
IIFtlTS; AOSTSILII; DBBO TRBflPT
a) Baccalo* fmoi* najor
t| Dlaphrag*
lltop*l«a of 13 people 72-99 yr old,
en drag ap to 10 yr vlth last done
3-22 hr before death.
CimiK; DtOOS; DBOO THSBlPtJ BBill;
BMIT; lot; (DOITS; 10SCLBS;
•OTOPSIBS
REfEIERCE
rlnley, J.P.
laxnan. I.B.
long. P.T.
Llckrl«h. c.B.
1979
Loaghnan,
1978
Krakaner, 1.
Steiness. B.
1978
-------
lM. l-iltzoaa- <8 CIt
B«tk*MllM. 1-Mtkyl-l-lltEOM- (9
62-75-9
C2-B6-B2-0
II 7«.1, BP 152 C
nssn
21*0
Blood.
•koU
BXIOmn BOOTB
fcUlRICll
BBTBOD
OC
Of
BOBBBB
or CUBS
3B
B1MB
"~
0-1.5 B9/»l
BB1B
O.C ag/ll
CBBBUl IBFOBBMXOB
lo •IgBlticiBt diff«n*e«* bctMvn
«•!•• IB *iok»c« 01 it IMtiBg
•«bj«ct«.
lorul nbjccu Bg*d 21-60 ji
BtTBOSIBIBBS; BLOOD; COBP»B»HM
ITILOtTIOIS; SBI; SBOHBG
BBFBBBBCB
Ukritx. I.
Siunhoff. B.I.
DUB, S.B.
Fiddler. B.
19BO
-------
DUetliylpolyslloxane (lo po«tlng» In CBEBLIBE).
TISSUE
21*1
Breast
21*2
Kidney
21*3
liter
2U»
Lang
21*5
Spleen
E IPO SORE HOOT!
Injection
Injection
.
Injection
Injection
Injection
iBiLTTicii.
BRBOD
IB
IB
TB
IB
IB
lUBBBB
or cisss
1
1
...
1
1
BkBGE
Bot glten
n-25 «9/100 g
26-3* «g/100 9
3B-323 19/100 9
- -
7»-7S 19/100 9
•e»B
5,335 19/100 9
21 19/100 9
31 19/100 9
1(3 19/100 9
T> eg/100 9
REBEBIL IBFOIRtTIOB
Scecieen obtained about 1 jr after
death o( 30 yr old. Death occurred
•ithin ilnate* after injection.
SltlCOI; BBttST; KIDBBTS; LUER;
LOlOSi SPtEll; C1SE HISTORIES
Sfecieen obtained abo«t 1 yr after
death of 30 jr old. Death occurred
•Ithln iinate< after injection.
SILICOI; BBJ«SI; KIDIETS; LIIEB;
tOICS; SPlIIBi CkSI BISTOBIES
Srecieen obtained about 1 yr after
death of 30 yr old. Death occurred
•ithin ilnetea after injection.
SUICOH; BBCIST; KIDIEIS; LITBR;
LOIUS; SPLEII; CtSE HISTORIB5
Speclien obtained about 1 yr after
death of 30 yr old. Death occurred
ilthin ainute* after injection.
SUICOI; BBHST; KIDRIS: LITSB;
IOBGS; SPtlM; CISC BISTOBIBE
SpeciMn obtained about 1 yc after
death of 30 yr old. Death occurred
eithin alnate* after iajecticn.
SUICOI; BBEIST; KIDBITS; II US;
IOIQS; SPLEII; CkSE HISTOBIEE
BEfZBEICE
RcCurdy, B.H.
Soloaone, E.T.
1977
Bccurdy, B.H.
SoloeonSf E.T.
1977
BcCardy, B.B.
Soloaona, E.T.
1977
Hccardy, B.B.
Soloione, E.T.
1977
Bccurdy. B.B.
Soloeone, E.T.
1977
-------
Olprcldo(1.2-«i2>.1>-e)prnclD«4ll», 6.7-dlk7dro-
276«-72-9
C12-R12-B2
I* 3M.07. HI belo* 320 C (decoap), aleo reported as 335-3*0 C
TX3SOB
21*6
Blood.
eorae
21«7
OClM
BIPOSUIB 100TE
Ingeitloa
Inaction
Deraal
IMIRICIL
•mop
BadiOaetrr
IOIBH
OP C131S
1
.
6
IIIOE
•) lot applicable
b) lot applicable
a) lot glT«n
b) lot gl»«o
nil
a) 2.S22 ppa
b) 0.312 ppa
a) 61. 2*
b) 0.3J
«I»ZUL IlfOBUTIOl
a) 3S.S kE after iBjastloa of leglone
(200 9 diqgit/1)
b| M ar alter iajutlon
Eiclag tkl> tlae, extracaporcal
keaodlalr«l( ••• aied. Deatk
occvrred *7 hr after Ingestioa.
as jr old
Suicide
PESTICIDES; BLOOD SBtOI; SDICIDB;
GIBHklT
a| IT doae of 1 «C1
b( Topical adalnlatcation of 1-5 uci
Perceatage of doae eiereted In 120
br. Data la b) corrected for
lacoaplete recovery baaed OB data In
•1'
Bialthr volaateera.
EISTICIDBS; HERBICIDES;
OB01IOPROSPH1TSS; CHLOBUB OIG1HC
CCHPODIDS; OtnE;
BlttCBlOIOCTCLaBlXMB
BEFEUICE
Okoaek. s.
Hofeann. i.
BeBBlageeo. B.
1976
Feldaana, B.J.
Balback, B.I.
197«
\o
-------
iM, i.i-diMthyi-, i-oxid« (8 en
1-Dod«c«n«aln«, 1,1-aiMthTl-, E-oilda (<» cil
1M3-20-5
CU-«31-«-0
8* 229.««
TISSUE
21«8
Slood,
»hol«
21*9
ocin*
EXPOSOIE IOOTE
-
Inq««tion
immciL
RtTHOD
Sadlo««try
-..,--
lORBER
or casts
2
2
it ist
0.25-0.6 ag/g
a) 36.e-»9.SX
b) «3.9-S7.3t
HEkl
0.«2 09/4
a) «3.3g of
f 1-doa»CTl-C1«)DOiO (p«ak nla
Tclaot««cfl
OIIHB; BLOOD
g) 2« he attic ing«stinC
b) 1*1 he aftn iH9«»tiog SO «g of
( 1-dod*crl-CU]DD10, total a«o«nt
Ctkac data available.
; BLOOD
HFZUICE
Blc«, D.P.
1977
tic*. D.P.
1977
vO
00
-------
•rgolU*-8-*c«toBltrU.«. 2-cUaco-C-»tkyl-.
369*5-03-6
C17-B1B-C1-I3
•I 299.83
nasoB
2150
Blood,
plasm*
inoaan IOOM
Ing«*tloB
aBURICll
BBTBOD
_,_
ladloMtry
OC/BS
IOBBBI
OP C1SBS
al 5
b) 1
c» 1
11101
•I IS- 2 ng/Bl
b) 5-118 ng/ml
c) 8-17 og/al
fflil
a| lot gl*»
b) lot appllcabla
c) lot applicable
,_,_____, , -,
OBI1I11 IIPOBBITIOI
•) !**•!• of radioactivity (u
l«cgotcll« aqalTalaata) 2 and 72 hr
•tt«r 3 «g (ISiCll of
l-C1«l3-l«cgotrll* Miylata-raraot
coapoaad not d«t«ct«d-data troi
graph-control*
b) Laval* of aorlargotrll* 30 and 120
•ii after 12.5 mg l*rgotrlla> • tl««a
dally foe 2 (k-parnt coipoand not
detected
e) Level* of Uqotill* 60 and 120 tin
aft«r 30 mg 5 tlM« dally tot 8 *k
OUu data available.
B«alt»y TOlaataaci. 21-38 yr old.
Itehacd BoiotUl H capital. Patlvnta
vltk ParklaaoB*( dlama*, 57-«« yr
old, latlonal In*tltat« of Malta.
MOOS; DBOC TBBBIPT; BBItBOtRBS;
HOOD PLISBl; II TITO iMLTSIS:
IIDItlt
BtmnBICB
»«bla, >.
Miborgac. L.
Dbaklr, P.
larrlck, P.
CrabteM, B.B.
Ob«ra«y*r< B.D.
tol«B. B.I.
BOM , B.
1978
VO
VO
-------
Erythroaycln
114-07-8
C37-H67-I-01J
91 733."»2. IIP 135-110 C
TISSOE
2151
Blood.
plasaa
2152
Blood.
seraa
2153
Blood.
seras
215*
Blood,
seras
BXPOSOBR BOOTB
Ingest Ion
Ingest ion
Ingest Ion
Ittgestion
IMLTTICIL
RETROD
Issanodlff asian
llcrobiological
-
Hlcroblological
. . ii . .
Rlcrobiological
IDRBEB
OP C»SBS
10
6
a) 11
b) 12
a) 18
b) 20
c) 18
d) 11
BUGS
a) 0.1-0.9 ag/al
b) 1.3-1.7 ag/sl
c) 1.5-1.9 ag/sl
d) 2.6-3.5 ag/sl
a) 0.01-1.16 ag/sl
b) 0. 03-1.13 ag/sl
c) 0.03-1.03 ag/sl
d) 0.05-1.13 ag/sl
e) 0.13-2.65 ag/sl
a) 1.693-0.097 ag/al
b) 3.361-0.516 ag/sl
a) 3. (-2.0 ag/sl
b) ». 1-2.8 ag/sl
c) 0.77-0.07 ag/sl
d) 1.2-0.18 ag/al
, -
HEUI
il 0.6 ag/sl
b) 1.5 ag/al
c) 1.7 sg/al
d| 1.6 ag/al
a) Rot given
b) lot given
c) lot given
d) lot given
e) lot given
a) lot applicable
b) lot applicable
a) lot given
b) lot given
c) lot given
d) lot given
GEItllL IIPORBITIOI
a) Single arythrosycin eatolato doae
b) single erythroaycln stearate dose
c) Repeated erythroaycln eatclate
dosea
d) Repeated erythroaycin atearate
doaea
Range is range of Beans for different
adalnlstration aethods. Levala are
(cc erythroaycln baae. Erythroaycln
2*-propanoate also present.
Raalthy volanteara aged 21-1! yr
(lean 29) and neighing 61-89 kg.
CB03S; AITIBIOTICS; EBTTBBORTCIIS;
EICOD PL1SBI
a) fcfter high carbohydrate aval
t) tfter high fat aeal
c) After high protein aaal
d) Faatlng
e) Faatlng
Sabjects given 500 sg erythrcsycln
stsarate vith 250 si (a,b,c,a) or 20
al (d) of aater. Peaks. 2 br after
doae. Bange is range of aeana.
2 fesalaa (22 and 21 yr old, 61 and
SO kg) , 1 aalea (22-33 yr old, 66-83
CBOGS; 1I1IBIOTICS; EBTTBBOBKIIS;
B100D SEBOB
a) Bange of seana. 0.8 and 6 hr after
11.8 • or - 2.2 ag/kg. Initial value.
1.27 ag/al at 0.5 hr. Fasting before
and after dose
b) Bangs of seans. 1.2 and 6 hr after
13.3 ag/kg. Initial value, 1.21
ag/sl at 0.5 hr. Fed 0.5 hr before
dose
Doae as tbe ethylaaccinate.
Pediatrlc patients. 6-65 so old, vith
scats infections.
la adverse reactions.
IBITBIOIYCIIS; DBOGS; DROG TBERIPT;
IIPBCTtOI; IIPUTS; CBILDBBI;
lOOISHBa; IITIBIOIICS; COBPUWIVE
IMLOiTIOIS
a) Faated. 10 ag/kg of the eitolate
b) red, 10 sgAg of the eatolate
c) Faatad, 1! sgAg of the
ethylaacclnata
d) Fed, IS sgAg of the
ethyleaccinate
Fasting, 2 hr before aad attar dose.
red, 118 si silk or forssla tits dose
falaea are 0.5-6 hr seans
169 stodies nre done vlth 106
lafants and children.
Infanta and children vith slid
aacocataneoaa infections, otitls
Bella, and pharyngitis, ages 2-16
aogths.
IITIBIOTICS; CBILDBBI; FOODS; BLOOD
3CIOB; StLITI; IEIBS; TBX»3; IIFillS;
COBPataTXTI miOltXOfS
BEPEBERCS
•ailing, P.G.
Elliott, R.L.
Fitter le, (I.E.
Corrick-Vaat, H.P.
Lyons, L.L.
1979
Veiling, P.G.
Boang, B.
Bevltt, P.P.
Lyona, L.L.
1978
Coyne, T. c.
Shas. S.
Chan, l.R.C.
Jeansonne, L.
Shlrkey, B.C.
1978
-
flcCrackan, G.B.
Glnabarg, c.B.
clahaen, J.c.
Thosss, a. L.
1978
(IMT riGB)
N)
O
O
-------
Irythroaycln
llt-07-8
C37-B6T-I-013
II 733.92. IP 135-1*0 C
(COITIIOIO)
nasoi
2155
SUIT*
2156
Tears
1
BIFOSOU 100IB
Inoestlon
IngestloB
lIUTTIClL
BBTHOO
.._
Bicrobiologlcal
Bicrobiologlcal
IUBBBI
or C»SBS
•1 38
b) 29
»7
ItlSE
a) 0.015-1.0 ag/ml
b) 0-3.0 sg/sl
a) lot given
b) lot gl»«n
c) lot given
d) lot given
Mil
•1 lot given
b) lot given
•I 6.1 ag/ml
b) 6.9 ug/il
c) 2.7 ng/Bl
d) 2.8 ug/il
CEIIUI
•I 10 ig/kg ««tol«t« calt. ««»n
0.87 «Bd 0.75 91/ml Cor fa*t«A «04
t«d, caap*ctlT«ly
b) 1 5 ag/«g ethylmcclaat* lalt,
••a* peak* 0.67 and 0.69 ag/il Cor
dated aad fed, c«ap«cttT«Iy
f«la*« ac« overall rang* (Caated plaa
(
-------
Bcythcocycln
Erythroaycio
1H-J6-1
C«0-im-B-01»
M 789.9% Sf 122-126 C
2'-proplon«t« (1 CI)
2'-proptnoat« (" ci)
TISSUE
2157
eiooa.
EXFOSOBB BOOTS
Ingaation
lMLTTICkl.
RETROD
IflBBBR
OP CISES
10
BifOB
al 1.5-2.8 naval
b) 3.S-«.5 og/»l
SB»B
a) 1.8 ng/al
b) 3.8 lg/«l
GEIEB1L IlfOiaHTOI
a) single •cytaroiycln ««tol«t« do*«
t) B«paat«d arythrcayela «atclat«
doa«s
>»ng« la range of Mans foe different
adalniatratlon 1010018. Erythroaycin
baae alao fcaaent.
tfaltay Tolantoocc aged 21-12 yr
|i*an 29) and neighing 61-89 kg.
CID3S; lETIBICTICS; BBITHBOIIICHS:
ElOOD PL1SS1
BEfBBBICE
Elliott! I.L.
Fitter le, I.E.
Corclck-Roat. R.P.
Lyona, L. L.
1979
N>
O
to
-------
B«tE«-1.3.5(101.«.8-p**t»«B«-3,17«lpb«-4iol (8 CI)
B*tCB-1.3.5(10).C.8-p*BtB«B*-3.17-alol, (17BlpkBl- (9 CXI
C639-99-2
C18-B20-02
If 268.38
TISJOB
2158
•da*
-
BXPOSBBB BODTB
aULTTXCIL
BBYBOD
oc
-
BBBBBI
OP C1SBS
Bl 12
bl 3
c| 3
1110B
-
B| lot give*
bl Bot «i»*n
el Bot given
-
m*
B| 69.* «g/2* kr
b) 1C. 3V2* kc
0 18.91/2* kr
8BBBUL XBPOBBMXOB
•I Po*tB*BopiBMl nbj«ct* gl»ei
copjig*t«d ••trogvB tablet* ABilr for
21 Oar*
b| POBtBVBOpawal a«bj*ct« glvca
coajBgat«4 •stcog«B tablet* 11.25 «g)
4*117 to* 21 4ay.
c) Po*tB«BOpm>al »b]«ct« gi*«B
copjagat«4 ••tcogcB tablet* (2.50 *g)
4ailr for 21 4ar«
BBBB 1* averaj* of lean* (or 4ay» 17,
1C, 19. Ba4og*BOBB level alao
12 healthy f«*al**, ag«4 37 to 57 yr.
•t S«-73 kg.
ROBBOBBSl STB10IDS; OBXBB; SHi
BUSOIBRIBT BRBODS
" UPBIBICB
Johuon, B. B.
Baieecuo, I.P.
Rbo, B.I.
14ai«, B.P.
1978
to
o
Co
-------
tatca-1,3,5(10) , ">-tetraen-1">-on«, 3-hjdcoiy-
«1»-86-2
C1B-H20-02
II 269.3*. at 236-290 C
TISSUE
Urine
EXPOSURE* ROUTE
tlllYTIClL
BSTROO
oc
ROHBEB
OP CaSBS
a| 11
b) 3
HalOB
a) lot given
b) lot given
HBll
a) it. 3 ug/2» hr
b) 1.9S/2I he
OEIIBal TirORUTXO*
a) posteenopaosal mbjecta given
conjugated estrogen tablets dally (oc
21 days
t) Postvsnopacsel subjects given
conjugated estrogen tablets (2.5 sg)
daily for 21 days
Rean is average of seans (or days 17,
18, 19. Bndogenoas level a Ho
available.
12 healthy fesales. aged 37 to 57 yr.
«t 5»-73 »g.
ROIROIES; ST BIO IDS; OBIIE; SII;
BlaSOlBUBIT S8TBODS
BEfEBEHCE
Johnson, E.I.
Rasserano, B.P.
Kho, B.T.
adaes. I. P.
1978
-------
I«tr«-1,3.5J10|,7-t«tr«»n«-3.17«lph«-4iol (8 CI)
l«trm-1,3.5C10).7-t«tr«M«-3.17-alol, (17*lpk*|- (9 CI)
6S1-SS-B
C18-122-02
Bl 270.36, n 205.5-205.6 C
n as OB
2160
ortB.
BIMSOU BODTB
iBunxcu
BBTBOD
OC
_
BOBBBB
or CISBS
•1 12
b» 3
el 3
1I1BB
-
•) Bot gt*«D
b| Bat «1»«B
c) Bot glT«fi
BB1B
a) 2».0 *9/2l kc
b) S.SX/2* hr
c) B.9I/2* he
CIIIUL XBPOBBtTXOB
•1 PostBCBOfaml nbj«ct« giT«a
cOBJ*gat«d ••trogco t«bl*t« aiilj foe
21 d«y»
b) POBtBMBOplHBX MbJoCtV giTOtt
coBJig*t«d ««trog*B Ubl«t« (1.25 19)
dBllr foe 21 d*T«
e) PostMBapuHl «ubj»ct« 9i»«n
conj«9*t«d •9* of MBB« foe day* 17,
18, 19. BBdogoaoiB 1«T«1 «l«o
B«*U«bl«.
12 h««ltb} f «••!••, «9«d 37 to ST jr.
•t S«-73 kg.
10BIOBBS: SIEBOXDS; raiBBi SH;
HtSOBBIBBT BBtBODS
BBFBBBBCB
JohBMB, B.I.
Baucrano, B.P.
no, B.t.
ld>BS. I. P.
1978
- -
-------
l«tca-1.3.S<10),7-t«tr««n«-3.17b»t%-dlol (1 Clt
I«tea-1,3.S(101,7-t«tr««B«-3,1'»-dl.ol. (17b*ta)- (9 CI)
3563- 27-7
C18-122-02
HI 270.36. It 17a.S-17«.6 C
IISSDB
2161
Orlm
EIPOSOBB IODTB
UlLYTICIkl.
DRIOD
OC
IOHBEB
or CISES
»l 12
b) 3
CJ 3
BlfCR
«) lot qlnn
b) lot firm
c) lot 9i««n
mi
*) 27. • 09/2 » he
b) ».7I/2« he
c) 5.0«/J« hr
GBIIItL IIF08HTIOI
• 1 Fo*tMnopiu«l nbj«ct« 9lT«o
canj«gat«d ••tcog^n tablet* tolly foe
21 a«r«
t) poitnaopaual (abjacts glT«n
coaj«gat«d •*trog«a Ublcti (1.25 19)
dally foe 21 day*
c) toftMnopaanl mbj*ct« glvan
coiija9at«d ••trog*B tablet* 12.50 19)
daily foe 21 day*
Raao la a*»ag« of Mau foe days 17,
16, 19. Endooanoai 1«T«1 alia
afillabl..
12 avaltky fa»l«>, aged 37 to 57 ye,
•t 5*-73 kg.
BCIIOIIS; SinolDS; OBI IB; SII;
EIISDIERIII BBTBOOS
IEFEBERCE
Johnson, I.I.
BaMecano, t.t.
Iho, B.T.
tdall, I.P.
1978
N9
O
-------
(t d|
I*teB-1.3,S(10)-trl«M-3.17-UoI.
SO-28-2
C18-B2V-O2
•I 272.37. a? 173-179 C
- (9 CI)
TXSSOI
2162
Orl»«
SXPOS0BB BOOTH
UUTTICIL
MTBOD
gc
or cats
•1 12
b) 3
c| 3
It Ml
I) lot 9i»«
b) lot 9lT«n
C) lOt 9lT«B
III!
*) 67.5 «9/2« kc
b| 5.31/2* kr
c| 5. H/2* kr
cuiui xiroiRitxoi
-
•1 Poitwnofiual nb]«cti gl»«n
eoB]«g«t*a •Mcogcn t«bl«t« Otllr Cor
21 a«T«
t) Po»tMBO(iu*l (Object* 9l»«B
CDBjigBtcA •>tro9«i tablet* (1.25 19)
dally Cor 21 4«T«
cl PoitB«BopBBnl nbj«ct» 9lr«B
coBjvgBtcl ••tcog«B t«bl«t« (2.50 19)
-------
tstradiol, 3-(bi.5(2-chloroethTl)carbaaata) dihydrogen phosphate (8 CD
Bstra-1.3.5(10|-trlene-3,n-diol (ITbeta)-, 3-(bis(2-chloroethirl)carbaaate) 17-(dihrdcogen
«8« 1-15-0
C23-H32-C12-1-O6-P
BR 420.43. HP 155 C (decoap)
phosphate) (9 CI)
TISSOI
2163
Blood.
plasaa
EIPOSOBE BPOTE
IngastLon
IIILTTtClkL
BETROD
HPtC
BDBBS9
OF OSES
BtlCS
al 268-993 ng/al
b) 23-86 ng/il
c) 32-200 ng/*l
d) 3-16 ng/»l
al 531. «5 » oc - 215
119/1!
b) »7.6» » or - 23
121.18 « or - 57
nq/il
d) 10.9 • oc - ».8
GZIIB1L IIP08IHTIOI
a) s«tcoaostlne
b) eatraiastine
c) tstcon*
d) Eitcadiol
••tabolltcs 1.5-18 hr after last dooe
of 280-«20 ag to pati«nt» on drag »
days-2.5 yrs. Haan daily dose 13.35
• or - 1.86 eg/kg. Other data
available.
with advanced prostate
lo gynecoeaatia deaplte estrcne and
eatradiol levels 100 tiees endogenoae
leveli.
CB06S; CHHOTBEBtPT; HUTS; DCOS;
BICOD VLtSBI: IEO?L»SaS; STE50IOS
Olson, R.
Brooks, B.
Gill, C.
1940
NS
O
00
-------
Mtroae (8 CI)
E«trt-1,3,S(10)-trl«a-17-oa«, 3-hydriwy- (9 CI)
53-16-7
C18-122-02
If 270.3C. IP fl-Con 2S».5-256 C
USSOE
216*
Ortae
inosaiB IORB
IIILTTICII
RETROD
oc
IOBBEB
or cisss
•1 11
bl 3
Ct 3
MIOI
•) lot given
b) lot glTra
c) lot given
.
mi
•I 330.* ag/2* he
b) 25.SX/2* hr
c) 26.8/2* hr
GEItUL IITOIB1TIOI
•I PostMnopimkl «abj«ct> gi*«D
con]«aat«d ••tcogcn tablet* telly foe
21 4ar«
b) Vo«tMBOF»««l Hb]«ct« giran
conjag*t«a ••trog«D teblct* (1.25 «g)
Silly foe 21 d«y«
c) Po«tMaop«a««l nbj«ct« givio
con]*g«t«d ••trogcn t*bl«t> (2.50 ig)
ItllT foe 21 4*T«
»««o la titttgm of M«U for days 17.
18, 19. En4og»o» !•»•! alio
•»ll*bl«.
12 healthy fmales, aged 37 to 57 TE,
it S«-73 kg.
aOBBOIBS; STEBOIDSi nilB; SK;
BI1SDBIBEIT BETBODS
•IFBIEICB
Johasoa, 1.1.
Ba«Mrano, ».p.
(ho. B.T.
tda««. l.P.
1978
to
o
VO
-------
ethane. l,1-4lct>loca-2-(o-chlorot>heoyl)-2-(p-chlocopHanrl) - (B C1J
lantene. 1-chloro-2-(2,2-dichloro-1-(«-chloraphenrl)*thrl)- (9 CI)
53-1q-0
C1»-B10-C1«
51 320.05. lit -"t-78 c
TISSOB
2165
UlpOM
2166
Blood,
pla*aa
2167
Bilk
EIPOSOBB BOOTB
lIlLITICIt
BBTROD
6C-BC
ac
QC
IOBBBB
OP CkSIS
•I 20
b| 16
C| 22
d) 17
29
29
-
JIIGE
a) lot given
b) lot given
c) <0. 0001-0. 2686 ppi
d) <0. 0001-0.005* ppi
lot given
lot given
mi
al <0.0001 ppi
b) <0.000t ppa
c) 0.0128 ppa
d) O.OOOS ppi
0.0072 pp»
0.0060 ppa
GKIIIIL IlrOBBlTIOl
a) 0-« rr old
b) 5-24 re old
c) 25-a» ye old
d) »5» re old
B«l«« and C«l«l<*
Other data (tlilabl*.
latopaUd tlam« (1969-70} fioa
ladlfldaala vith nc kaora
oecgpational «ipo««r« «ho bad llrad
In th« Xaipala c«gion of Oganda.
FISTICTD1S; CBLOBIII OlOallC
CCBPOOIDS; DR: DIILOBIl: 8IRICBLOB
ElonoB; iOIEOSE TISSOB; 001ID1;
BlUCHLOSOCtCtOHUHt: ODD; IDE
p«cc«otagai of ocgaaochloclnc
in**ctleld*a and PCB's in lilk of
•othcci 20-29 T«aca tban 30-39,
althoaqk tha foraac kad lonat !•»•!«
In plasaa. OTarmight voaan had
lonac la*al* than IOMB of nccaal
Might, laaldtwi concentrated in
attracted llpida of plaaa* and Bilk.
Israeli «oaen 2-» dara after noraal
deliterr-
flSTlCIDES; BLOOD PL IS HI; BUR;
fOPOUTIOl IIPOSOIZ; T3B»El;
CBLOIIHTBD BTDIOCUBOISi LIHOS;
ISC! DDT; DCC: DOB; POLTCBIOHI1TBD
IIPBBITISi BEPT4CB101 EPOIIDI;
BIIiCBLOEOCICLOBIIIIE
Bigher percentage* of organochlorin*
Iniactlcidaa and PCB'a in ailk of
aether* 20-29 year* than 30-39,
althoagh the foraec bad loa-er level*
in plaaaa. Oiarnaight voaen had
loner level* than «oa*n of notaal
Height. le*ldae* coaoeatrated in
attracted liplda of plaaaa and nilk.
Iiraeli noaa* 2-* dar* after aoraal
d*li«ecy.
MSTICIDBS; BIOOD FL1SBI; Bill;
PCPOLITIOI IIPOSOBE; XSUBtl
CBIOIXIITBD BIDBOCMBOBS; LinDS;
l«li DDT; DtC; DDB; MlTCRLOIXIlTBD
BIFBBITtS: BCPTtCBLOl BPOIIDI;
BIHCHIOIOCICLOBHIBB
BBTEREICB
laaaariann, B.
Toaati*. 1.
Va***raaan, D.
Dar, ••'•
DjaTaherian, n.
I97a
Pollahak, Z.I.
Ion. B.
laaaeraann, B.
Cocoa, s.
laaieraaan, D.
Laaaach, C.
1977
Poliahak. t.».
Son, B.
laaaeraann, 8.
Cnco*, s.
la**areana, D.
Laaaach, c.
1977
-------
Ethll*. 1.1-dlckloro-2.2-bli{p-cklOEpkMrl|- (• CD
Bam*. 1.1'-(2.2-4lckloro«tkrli4in«)bli(*-ckloro- (9 CI)
72-51-8
CK-B10-C1*
II 350. «6, II 221-222 C
TXSSDI
2168
2169
adlpoia
2170
IdipoM
2171
141 poll
inosou tooiB
lllLTTICll
BBTBOD
SC-BC
OC
oc
CC-BC
OC-BC
IOBBBB
OF CtSBS
I) 26
b) 22
O 27
d| 18
•1 18
f) «
168
a) 20
b) 16
c) 22
4) 17
*) 26
b) 39
e) 122
4) 99
•) 151
f) 70
ikMi "••"
a) <0.0001-0.0«28 ppi
b) 0.0028-0.71*0 ppi
o) 0.1085-7.0*50 ppi
d) <0. 0001-0. 1125 ppi
•) <0.0001-0.1666 ppl
f) 0.1270-2.9166 ppi
0. 002-0. *02 ag/g
•) 0.0055-0.5569 ppi
b) 0.0079-1.1*60 ppi
c) 0.0053-1.35*0 ppi
d) 0.006*- 1.2*1 6 ppi
I) lot glvm
b) lot glv*B
c) lot glt*B
d) lot glra
•) lot glv*B
f) lot glriB
BB1I
•) 0.013* ppi
b) 0.1913 ppi
c) 1.8190 ppi
d) 0.01*6 ppi
•) 0.0192 ppi
f) 0.9769 ppi
0.006 ag/g
•) 0.0706 ppi
b) 0.1301 ppi
e) 0. 10*6 ppi
d) 0.1206 ppi
a) 01* ppi
b) 14 ppi
e) 10 ppi
d) 11 ppi
•) 10 ppi
f) OB ppi
GZIIU1 XirOIBHXOB
•) 8*1*1 - itlllborn
b) Bilu - 0-11 10
c) Balii - 70* yr
d) MMtei - itlllbon
•) riitlu - 0-11 10
t) F«ial*i - 70* it
Data avallabl* for lnt*ri*41at« ag*
gcoapi.
latopir lp*ciMBi, 1967-1971, froi
lira* 111 iltk BO kion occipatlonal
•ipomN.
IISTXCXDBS; XISBCTXCIDBS; CBIOIXIB
CEOIEIC COBfODIDS; DDT; ODE; ODD;
DXILDBXB: BSmCBtCI EPOIIOE; 1DXPOSB
IXSSOBi ISI1H; BBUCBIOBOCTCLOBBXtEB
Canadian! troi Zait«rB Canada (16) ,
CMbic (50). Ontario (57). Central
Canada (22) lid l«it*ri Canada (27) ,
1972.
PZ3HCIDB3; CBLOBIIE OBOtBXC
CCBPO0IDS; DBT: dUDBXE;
(OLTCBIOBXBITBO BIPHBITlSj DCB; ODD;
ICI1CBLOE; BIXlCBLOBOCIClOBBXlEBi
OIICBLOIDllIi BBPHCfllOB BPOXXDE;
IOIPOSB tXSSOB; CIIIDa
•) 0-* re aid
b) 5-2* re oU
c) 2S-M yr old
d) «S» yr old
lain and (mill
Othac data mllabli.
UtopiUd tlira* (1969-70) froi
individual* iltk BC knovn
cccopational •ipoioc* oko kid llnd
la tk« Kaapala ccgloi of Oginda.
fSSnCXDIS; CBIOBXBB OIOIIIC
CCBP001DS; DRt D1ILDIII; BIRtCBlOl
IIOXXOB; 1DICOSI TXSSOBi OOilDi:
IIItCBLOBOCiaOBKMI; 000; COB
a) 1969
t) 1972
c| 1969-72
-------
(than*, 1,1-dlchloro-2,2-bia(p-chlocphenyl)- (8 CI)
Benmne, 1, 1'-(2,2-4ichloroethTli4en«)blB («-cliloro- (9 CII
72-5»-8
CW-B10-C1*
If 350.«6, at 221-222 C
(CCHTIiOBD)
TISSOI
2172
BlOOd
2173
BlOOd
2l7a
Blood.
plasaa
2175
Blood.
serna
2176
Blood.
vhole
EIPOSOBB BODTB
kllLYTXCU.
BBTBOD
GC
GC
GC
CC
GC
BOBBER
OF C1SBS
7
a) 121
b) 497
29
1
26
BIIGE
3.0-23 ppb
a) 2-70 ppb
b) lot given
lot given
lot applicable
lot given
tlEll
._
11.6 ppb
a) 11 ppb
b) 2.5 ppb
0.0087 ppa
5.0 ppb
0.010 ppa
GIBIBIL IIFOBI1TIOI
1975 Yugoslavia survey, 140 laaples
shoved no p.p'-TOE. Valnes are for
aeraa or plasaa.
65 sales and 82 fenales, aged 8 to 92
yr (aean age *2 yr) in Croatia.
BIXICBIOROCTCLOBIIIEE; DDE; COD; DDT;
C1STICIDBS; BLOOD SEBOB: BLOCD
PUSH; lOGOSLaVIt; CRLOimiZD
BIDIOCIBBOES
•) Sasples in vhich p, p'TDE «aa
positively identified
b) til sasples
Postsortess, virgicia State Radical
Exasiners Office, 1972. about 45*
froa shite sales, 30* fros black
sales. 15* fros "Bit* feiales, 10*
(cos black teaales.
CBLOIIIE ORGIIIC COBPOOIDS; COT; DDE;
CIZLDIIB; (IBGIBIl; BLOOD:
EISTICIDBS: POIYCRIOBTBaTBD
tIPBEITLS; BmCBLOIOCTCLOBEUEE;
BIPTiCBlOl BPOIIDE; CBLOBIB1TED
BIDROCUBOIS
Bigher percentages of organochlorine
lassctlcldes and PCB'a in Bilk of
sothers 20-29 years than 30-39.
although the foraer had lover levels
in plassa. ovarveight noson had
lover levels than vosen of acreal
•eight. Besidues concentrated in
eitracted lipids of plaaia and Bilk.
Israeli vosen 2-4 days after norsal
delivery.
MSTICIDES; BLOOD PLiSSi; 81 IK;
POPOLHIOB BIPOSOBB; ISBkIL;
CBLOBIBkTBD BYDBOCUBOBS; linDS;
>OE; DDT: BCD: DDE! POLYCBIOJIHTED
BIPBEITLS; BBPTICBLOB EPOIIDI;
B IXICBLOBOCICLOBK IBB
Bonsehold dgat levels 2.22-19.21 ppa.
Idnlt farser froa Beld Coaaty, CO.
(ISTXCIOESj DDT; DOE; LIIDIII;
BEPTaCBLOl EPOXID1; CBLOBIBB OBGIBIC
COBPOOIDS: DIELDRII; BLOOD SIBOB;
COLOBaDO; DOST: BBHCBIOROCYCIOBEXIII
occnpationally eipoaed to DD1
in: DDE: ADD; PESTICIDES; BIOOD;
IMPOSE tISSDE; CaBlDa; OCCOHTIOBaL
BUtRDS; IQTOPSIIS; BIOaCCOBOLITIOB
IEPEBEICE
Reiner, t.
Kraathacker, B.
stipcevic, a.
Stefanac, Z.
1977
Griffith, F.D. , Jr.
Blanke. R.T.
1975
Polishak. S.I.
Bon, B.
Vassersann, fl.
Cocoa, S.
•assersann, 0.
Lesesch. C.
1977
Starr. B.G.. Jr.
ildrlch, r.D.
BcOougall, l.D.
Boance, L.I.
1974
Brovn, J.B.
Choi. L.T.
1975
(HIT PaGI)
-------
Btkaa*. 1.1-dicUoro-2,2-bl>(p-cklorpbmyU- (8 CI|
Bmxm*. 1.1i-(2.2-dlckloro«tbyUd*M)bl«(*-cklOEO- (9 CX)
72-S«-8
CI*-BIO-CI«
•• 350.«6, HC 221-222 C
(COBTIIDBD)
TISSUE
2177
Bilk
2178
Bilk, fit
2179
Bilk, fat
BUOSVBB BOOTS
aBlLTTIClL
BBTBOD
OC
OC-BC
OC-BC
BOBBBB
OF CaSBS
29
a) 53
b| 33
a) 3«
b) 6
BklOB
Bot glTOO
a) lot dat«ctabla-1. »5
PP«
b) Bot datactabla-0. 3«8
ppi
a) 0-0.43 ppa
b) 0-0.01 ppB
BEIB
-
0.0099 ppB
a) 0.151 PPB
b) 0.023 ppi
al 0.0* ppa
b) 0.002 ppa
GEimi motuTioB
Blghac pirc«Btigo« of oEgiaochloElai
inaacticldoa and PCB'« la illk of
•ctkcra 20-29 yoici thin 30-39.
altboagk tk« forioc had IOVOE lovols
IB plaaaa. Oacvalgkt *OMB kid
loirar la»«la tfcaa IOBVB of noraal
••lgkt. B«aida«a caBctntratad is
•itcictod lipldi of plaaaa and Bilk.
lacaali woiao 2 -a day* aftar noraal
PISTICIDBS; BLOOD PUSBlj BILK:
•OPOLHIOE IIMSOBI; XSBtBL;
CBLOBIBaTBD BTDBOCHBOBS; LXRDS;
aCl; DDT; OCD; DOB; POLTCBtOaTBlTBD
BIPBBITLS; BtPTlCILOB EPOIIDI;
BIXaCBlOBOCTCLOBIXIBB
a) 1966-1970 atudy
b| 1977-1978 atgdy
1966-70 pattanta, (nnl»araitj of
llbarta Boapltal), 2-10 days
poatpactoa. 1977-78 p«tin«ta (public
bailtk off leu of albccta) , 17-309
days poitpictu. Swldoacoi, Bdioaton
OE llbarta.
BILK; PESTICIDES;
BIUCBLOBOCTCLOBIXIBB; ODD; COB; DDT;
DIILOIII: atPHCBtCl BPOXIDB;
BlIaCBLOBOBEBSBBB; CtRlDl;
fCtrCBLOBUlTIO BIPBBBTtS;
COBPtBaTITB BTaLOllIOIS
at Blgk poitlcid. oaaqa aE«a
ct to« paatlclda naag* acaa
toaan living la Stackvillo,
Biiaiialppi (Ion paatlcida aaaga) and
Dalta acaa (klgh paaticid* uaaga).
Saaplaa la 1973-1975.
BILK; PESTICIDES; GDB; ODD; DDT;
BIltCaLOBOCICLOBIIaBE; BBPTkCBLOB
BtCIIOB; OXTCBLOB01BB; DIBLDUB;
(ISSISSIPPI; COnPtBtTITB BTlIOaTIOIS;
•ItSOIBBEIIT RBTBODS
_
BBTBBBBCB
Pollakik, I.i.
Boa, B.
••••IEIIBB, B.
cacoa, s.
laiMfaana, D.
Laacach, c.
1977
Cacrio, B.a.
Kadli. ».«.
Braltkraltx, B.E.
Caaalagkn, 6. B.
Bcona, G.«.
1979
Bacaatt, B.I.
D« Creole, t.J.
Cain, J.D.
Icthnr. B.D.
1979
to
-------
tthani. 1.1,1-trichloco-2-(o-chlorophinrl)-2-(p-chlorophinrl)- (8 CI)
Binnni, 1-chloto-2-(2,2.2-trichloro-1-«tnyl|- (9 CI|
789-02-6
CU-89-C1S
91 35*.«9. BP 7»-7«.S C (COC)
TISSOB
2100
kdipoac
2181
•dlpoi*
2182
adipoii
2183
Idipoil
EIPOSOIE BOOTE
nitmcu.
RETROD
OC-8C
CC
GC
GC-BC
GC-BC
ItJflBEB
or CaSBS
al 26
b) 22
c| 21
d) 18
•) 18
f) 13
168
•1 20
b) 16
c) 22
4) If
•1 26
b) 39
c) 122
d) 99
•I 151
0 70
BUGS
a) <0. 0001-0. 0260 pp«
b) <0. 0001-0. 1100 pp«
c) 0. 0180-0. 9800 ppi
d| <0. 0001-0. 0820 ppl
•) <0. 0001-1.050 ppl
f) 0.0*55-10. »010 ppi
0.001-0.229 09/9
a) 0.0005-0.2518 pp«
b) 0.00*2-1.6180 pp«
c) 0. 0052-1. 2*5* ppi
4) 0. 0103-2. 3529 ppi
a) lot gi»in
b) lot g.l»«n
c) lot glrin
d) lot gi*m
•) lot glT«D
f) lot qirin
(isrr
1B1I
a) 0.0100 ppn
b) 0.0130 ppa
cj 0.2381 ppi
4) 0.012S ppi
a) 0.1320 ppi
fl 0.1535 ppi
0.031 ag/9
a) O.OS11 ppi
b) 0.1588 ppi
c) 0.11*3 ppi
a) 0.187* ppi
a) 0.3* ppi
b) 0.25 ppi
e) 0.2* ppi
4) 0.25 ppi
•I 0.2* ppi
f) 0.2* ppl
...
FtOt)
GEIEBIL IIFOSIiTIOR
a) Hall! - itlllbocn
b| HaUi - 0-11 10
c) Sales - 70> it
d) main - stillborn
• 1 Peial«» - 0-11 10
(I Piialca - 70* re
L« t«l* at* (oc o,p'-DDT»o,p' -ODD
Data availabli (oc lnt»r»«4i«t« >9*
qcoipc.
litopij ip«ciMn«, 1967-1971 from
Kcailli Kith no known occupational
aiposnn.
tisnciDBS; nstCTiciDis; caionis
CICtllC COBFCOIOS; DOT; DOB: ODD:
CIIIDIII; BtntCBLCR BPOIIDE; 1DI7OSB
1TSSOB; ISBUL; BBXaCBlOROCTCLOBBXalB
Canadian! fcoa Eaiticn Canada (16) ,
Cubic (SOI , Ontario (57) , cotcal
Canada (22) and v««t«n Canada (27) ,
1972.
einxciDiSi CILOIIIE oiomc
CCBPOOIOSi OM; OII1DBII;
EOLTCelOIIIlTID BIPHBIttS: DtBj ODD;
ICIaCRLOB; BtUCBtOIOCTCLOREIalB:
OKCBLOIDlIC; BBPTICBIOB BPOHDB;
IDIPOSB TXSSOli C1»D1
I) 0-« fC Old
b| 5-2* JL Old
c) 25-«» it old
d) *5» re old
9*lu and (••*!••
Otkic data a»ailabla.
latopilid ti*m« (1969-70) (toi
individiali Kith ne kaoin
occapational •xpoio.?* vho had LiTid
la tlii Kaipala cigion of Oganda.
PHIICID1S; CBLOIIBI OIGallC
CCIPOOIDS; on: oinnxii BERICBLOB
ItOIIDB: aDICOSE TI3SOB; OQaHU;
BttlCRlOIOCICLOBIIIIB; DDOJ COB
I) 1969
t| 1972
e) 1969-72 (f Ma 111)
41 1969-72 (Mill)
•) 1969-72 (Bixican-tliclcan)
f) 1949-72 (non Rixlcan-tiirlcan
Pitiinti andicqoinq •l«etl*« sugicr
in 1969-72 in thi lowic Bio Crandi
(alter of aoathiait Tins.
PISTICIDBS; DDT; BBPHCBLOI ZPOnDE;
CBLOIIIE OIGIIIC CCRPOOIDS; IDIPOSB
TISSUE; TEttS; BBXaCBtOBOCTCIOinilB:
tCE; DDD; D1EIDBXI; POLTCUOHIiTED
EIPRBinS
BEPEFS'CE
• asuriann, u.
Toiatia, 1.
lamriann, D.
Day. ».E.
Gconic« T.
Lazacovici, S.
t>os*nf*ld, D.
197*
n«a, j.
Calpball, D.S.
Pobinion, B.I.
Darin, D.J.I.
1977
lamciann, R.
Toaatii, t.
Vawwriann, D.
Dar, I.I.
DlaTahician. E.
197*
.
Bine, J.I.
197*
_
NO
-------
Btaaa-, 1,1,1-tricU.oro-2-(o-chloroph«nyl)-2-oa*n of ncraal
(•Igkt. B«aldaaa conoantrataS la
aitcactad llplda of plaaaa and allk.
tataall (oaaa 2-a daya aftac nocaal
dall*acy.
PISTICIDSS: B100D R.1SB1; BIIK;
PCPOLITIOI HPOSOB1; ISBlEL;
CBLOBXIlTID BTOIOCHBOIS; LItlDS;
ICIj DDT; ODD; DDI; POLTCBLOIIBITBD
EXPBIinS; BBPTaCBlOB EPOIIDI;
BIXkCBLOIOCTClOBCXHE
Illk aaaplaa. koapltala la acbaa
oalo. 4 aaaplaa fcoa lalllagdal. a
(allay In icnthatn lor way. Bo
cccapatloaal axpoaaca.
BUR; IISICTICIDIS; UCT4TIOI;
CCLOIIBtTBD BIDBOCIIBOISl CBIOBIBI
ooiiic COBPODIDS) PESTICIDE;; »omt
a) laataca Canada
t) ooabac
c) Oataclo
d) cantcal Canada
at Waatacn Canada
(1 latlonal a(-caga, aaaplaa abova 1
ng/g
latloaal Sacray, 197S
IIPREITL COB tOO IDS 1 CaltDl: CHLOBIIE
CI01IIC COBPOOIDS; DDE; DDT;
CIILDBIl; BEPTaCBLCI EPOXIDE;
BIIaCILOIOBEnEIlE;
BIItCBLOIOCTCLOBIIIIE; BILK;
lOlkCRLOt; OITCBlOtDklE; PESTICIDES;
CCITCBLOBIIITED BIPREITLS;
fCLICHLOBIIITID TIIPBBITLS
BEPEBEICE
Pollakak. I.I.
lea. I.
laaaacaaan, B.
Cacoa, s.
BaaaacBBBB, D.
Laaaach, c.
1977
.
Pollokak, Z.I.
Boa. B.
laaaaraann. a.
cacoo, s.
laaaacBBBB, D.
Laaasch, c.
1977
Bakkm. a.r.
s«lp, B.
1976
Baa, J.
Davlaa, D.J.
1979
Ul
-------
1.1,1-trlchloco-2-(o-chlorophenyl)-2-(p-chloroph«oyU- (SCI)
, l-chloro-2-(2.2. 2-tticUoro -1-(«-chloroph«nyl) ethyl.) - (0 CD
169-02-6
CU-B9-C15
Bl 35».»1. Bt 7«-7».S C (COC|
(COITIIOE9)
TISSOE
2181
Illk. (at
2169
Silk, tat
BIPOSORB BOOTS
HIALTTICkL
BETBOD
GC-BC
— — 1
RO!>-70 patlinta (Oal<«c«lty of
lltacta Hospital). 2-10 days
postpactni. 1977-78 patients (public
b«alth off lc«» of tlb«cta) , 17-309
days postpactm. guidances, Ediontoo
cc >lb«rta.
BILK; PESTICIDE S;
BIUCBLOIOCTCtOBKtlE: ODD; COB; DDT;
OltLDBIl; BIFTACBLOI EPOXIDE;
EIItCHUBOBEIZBK; CtltDi:
tCltCBLOBlmilD BIPBEIILS;
CC(IP»BITI»E ETIlOaltOIS
a) Blfk pcstlcld* as«q« aria
t) ton pistlcld* osaqe ar«a
«OMD living In Stack* 111* ,
Blsslsslppl (lo« pcstlcld* usage) and
Dilta acia (high putlcld* aiag«).
Sa.pl«» In 1973-1975.
BILK; PESTICIDES; CDZ; ODD; COT;
amcBioiocicLOHtniE: BRPTICBLOB
BtOIIDE; OIICnOIDIIB; DISLDill;
CISSISSIPPI; CONPIBtTITE ET1I01TIOIS;
BtlSOSBKEIt BET BODS
BEFE9EIICE
corrln, e.i.
Kadis, T.H.
Bceltkreltz, H.E.
Cannln9hai, G.B.
Beans, G.I.
1971
Barnctt, B.I.
D'Eccoli, >.J.
Cain. J.D.
Arthur, l.D.
1979
to
-------
Ithana. 1,1.1-trichloro-2,2-bla(p-ckloropkaBTl»- (8 CI)
Banana. 1.1'-<2,2.2-trlchloroathylid«n«)bia(«-ckloro- (9 CI)
SO- 29-3
CU-B9-C15
H 35*.50. Si 108.5-109 C. BP 260 C. TF 1.5110(8-7) » 89 «t 20 C
nssos
2190
Idlpom
2191
kdlpom
Ulpos*
21«3
IdipOM
BIFOSOBB IOOT8
IMLTTXCkL
•BTIOD
6C-BC
CC
DC
GC-EC
IOBBEB
OP CiSBS
«) 26
b| 22
e) 27
d) 18
•) 16
CI 13
168
b) 16
C) 22
4) 1-»
3
UNB
a) 0.0030-1.2500 ppi
b) 0.09*0-5.0000 ppi
c) 0.3570-3*. 2650 ppa
d) 0.0026-0.3*80 ppa
•) < 0.0001-1.7650 ppi
f) 0.51*0-12.7010 ppa
0.018-2.057 ng/g
a) 0.0*09-*. 9235 ppa
b) 0.0363-9.5000 ppi
c) 0.0200-«.613S ppi
d) 0.06*2-6.7278 ppi
i) 0.*8-0. 6* »g/g net «t
b) 0.26-0.3* 19/4 ««t «t
c) 0.26-0.35 ug/g vat «t
- •tlllbora
b) 8al«* - 0-11 ao
c| Bal«a - 70* ji
«} rvailaa - atillbora
•) Paaalaa - 0-11 ao
(I Faaalai - 70* yr
Data arailabl* (oc tat«ra«di«t« tg*
9tonp«.
latopay ap«cla«Da, 1967-1971. froa
lacaalla ulth no kooin occapatioaal
•ipaaaca.
1ISTICIDBS; IBSBCTICIDBSi CBIOBIIB
C10HIC COBCOOIDS: DDT: DDB; ODD;
DUIOBII; BBPTiCHLOl BPOXIDB; 1DIPOSB
1ISSOB; ISE1BL; BBUCRlOBOCICLOBBItBB
caaadlaaa (coa Baa tare caaada (16) .
floabac (SO) . Ontario (57) , Cantral
Canada (22) and laatarn caaada (27) ,
1972.
RISTICIDBS; CBIOBIIB OBGMIC
COBPOOBDSt DDT: DIllDBII;
COLTCBLOBII1TEO BIPBBBTLS; DIB; ODD;
lOlkCBLOB; BEIlCBLOBOCIClOBIIiBB;
OIICBLOIOIII; BBPT1CR10B BfOIIDB;
tDIPOSV TISSOB; ClItDt
, , ,
b) 5-2* re old
c| 25-** yr old
d) *5» yc old
Balaa and (aaalaa
otbac data availabla.
latopaiad tlama (1969-70) fioa
IndlTldaala aitk nc knon
ocenpatlonal aipoaaca «ho had lind
In tha (aapala cation of Dganda.
PISTICIDISt CBIOBIIB OBC1IIC
COBPOOIDS; DOT; DICIDBII; BBtTlCHlOfl
CEOUDE; IOIPOSB 1ISSOB: OGllDt;
BIXkCBLOBOCTClORIXIBB; ODD; COB
a) Saipla 1
t) saapl* 2
c) Saapla 3
Una ditfarant acltanta taatad.
Tlaaaa eollactad dating aatO|aiaa on
accldaat victlaa.
CBIOBIIB OBGtBIC COBPOOBDS; JO I POSE
TISSOB; COBPmtH! CT»LO»TIC»S;
lOTOPSIIS; PISTICICBS; DDT; FBTHiLIC
ICIDS; POIICBIOBIHTBD BIPBBITLS
BBTBBBBCB
Vaaaaraann, B.
Toaatia, 1.
Vaaaaraann* D.
Day, B.B.
Gronar. T.
LaiaroTici, s.
BoaanCald. D.
197*
Baa. J.
Caapball. D.s.
Boblnaon, B.B.
Dafiaa, D.J.I.
1977
Toaatia, I.
Raaaaraannv D.
Day, I.B.
Djavaharian, R.
197*
Raa, J.
Caapbcll, D.s.
1976
ro
-------
Ethaae. 1.1.1-trichloro-2,2-tls(p-chlorophenrl)- (n CI)
eenteae. 1,1'-U>2.2-trlchloroethrlidene)bla(t-chloro- (9 CI)
Cia-H9-ci5
III 35«.SO, IIP 108.5-104 C. «P 260 C. »P 1.5X10{«-7) BB Rg «t 20 C
(COITIEOED)
TISSO!
219«
Adipose
2195
ftdipOSe
2196
adipose
2197
Adipose
2198
Blood
EIPOS08B SOOT I
Inhalation
Ingest ion
»I»LTTIC»L
RETROD
OC-EC
GC
OC
IDRBEB
OT CIS 35
al 26
bl 39
e| 122
4» 99
•1 151
fl 70
268
a> 33
b) 17
1
•1 92
b) 26*
B1IOE
•) lot g Iran
b) lot given
c) Rot gives
1) lot given
e) lot given
() lot given
lot given
•) lot gi»«n
b) lot gives
0.33-0.37 ft*
a) 0. 005-0. 08« ppa
b) 0.001-0.077 ppl
HER
RB»I
tl a. 12 ppl
b) 3.06 ppa
c) 3.62 pp«
«) 3.30 pp«
•) 3.8* pp«
f) 2.70 pp.
1.260 >gAq. fala*
ll »dian.
a) 0.9 ppi
b) 0.3 ppi
lot 7l*«a
a) 0.019 ppa
b) 0.01* ppa
NOB)
OEIIItL IIPOBIHTIOI
a) 1969
t) 1972
c) 1969-72 (traal»l
d) 1969-72 (aal«a|
• ) 1969-72 (Mxican-iaacican)
I) 1969-72 (noa BBiicaa-*a«riea)
(atlants undergoing vKctir* aacgarr
in 1969-72 IB taa lovac Pio Graad*
lallay of aoathcast Tens.
PISTtCIDES; DOT; H1PTICHLOB IPOtlDE;
CUOIIIE OICIIIC CCIPOOIDSi IDIPOSE
1I5SOE; TEI15; HEIiCRLOIOCTCIORtXalE;
Dtl; ODD; DIEIDBXI: NITCBLOIIIITID
(IPREinS
Sibcataacou natcal fat ftoa the
iBitltnta* foe Pathological Inatoay
aad Por«n«ic Radlcia*. 1971-1973.
P1STZCIDES; BILK; FtTS;
CIECROSLOTlIIk:
RiiiCRioiocTCtoaiiiit: DDT; CDE:
HlIlCRMIOBEIZBIE
a) OrMBlaBdaca. 20-75 Ji old.
(aiplata tak«a daiiag aot«
lapacotoalaa. Rlganst U 22-«5 jc
olds
b) DaMI. 1-75 It old, *add«a death
t} •aleld* OE la aato ace id* eta
Badian Talaaa, buad on llpld «t
l«t lit valata available.
Eca«nl>Bd Doniodaatcialixad area
tmaack lodaatclallxcd.
1DIPOSB IIS30B; lot; aOTOPSIES;
CHOBIIE OleiBIC COBPOOIDS;
PIStlCIOBS: ODD; DEI; DOB; DIBLDUI;
BEPT1CRLOB EPOIIDB; POLICRWRIaTED
eipREiris; coRPiBinn ET«LOITIOIS;
POPOUTIOI IXPOSOIBt aBEBBUD;
dilute
Concentration rang* »-5« dajf
iagaation of 170.1 g 751
dlehloteBthloB.
salcld* atteapt br 62-rc-old aal«.
SOICIDE; ftOBIDI; lOTOfSIBS; BLOOD
SBBOH: IDIPOSE TIS30B; IITBI; OU.I
BUDDIES KIDIETS; P1STICIOBS;
OlglBOPBOSPBITES; BLOOD: DDT: DDE:
CIILD1II) RIPT1CBLOI EPOIIDE;
BIUCBLOBOBBnllE; LlTtOE) ItDIOMOIC
BIIIFE3T4TIOISI BIOIOCOROLITIOI;
BETUOLIIES
a) Paraeca la Oataiio, 1970- 1972
b) Packara aad othacs, IB Ontario,
1970-1972
Oat* OB UT*U IB aoil and fish alao
afallabl*
Paraara and packing hoan «a(lor*«>
IB Bollaad Rarah, OBtarlo. atartiag 6
•o after DDT «a» baaned there.
PISTICIDES; DDT; BIOOD; C1B1E1
RETE8EICE
Barna« J.E.
197a
Szokolay, t.
Eoairal, L.
Ohaak, J.
Radaric, 1.
1977
Jeaeen, 6.E.
Cltaaen, J.
1979
Davlee. J.I.
Bargaet, i.
Freed. t.H.
Bagae, B.
Borgade, c.
SoaaebOEB, S.E.
Tacla*ek, c.
1975
Broia. J.B.
ChOK, I. I.
Chal. F.C.
1975
oo
-------
Btkan*. 1,1.1-triekloco-2.2-tla(p-ehloropfcenrl)- (8 CI)
Baana*. 1.1>-(2.2.2-tcickloco«tkrUi«M|bl*(*-ckloce- (9 d)
50-29-3
CW-H9-C15
BI 35».50. IP 108.5-109 C, B> 260 C. TP 1.5110(8-7) » 89 at 20 C
(COITIIOBD)
TXSSHR
2199
Blood
2200
Blood
2201
Blood.
plaaaa
2202
Blood,
plaaaa
BXPOSOIB BOOTS
1IUTTICU.
BBTBOD
OC
OC
OC
oc-«c
BDBBBB
OP ClSBS
..
20
a) 198
b) «97
29
•1 23
b) 23
c| 1«
BtSQB
2.2-81 ppb
- -
a) 2-125 ppb
b) lot given
._
Bot giTan
at lot given
b) lot given
c) lot glTan
(ttrt
BBll
22.7 ppb
a) 12 ppb
b) a. 5 ppb
0.0133 ppa
al 3.86 ag/1
b) 3. 21 ag/1
e| 3.21 ag/1
PIGB)
flBltUL IBPOBBMIOB
-
1975 Tagoalavla aacray, 127 aaaplea
akoiaid no p.p'-DDT. Tala*> are foe
aacaa or plaaaa.
65 aalaa and 82 faaalaa, ag*d a to 92
|c (aaaa aga 42 yr| IB Croatia.
BRaCBLOBOCTCLOBIXMB; ODB; ODD; DDT;
MSTZCIDBSi BLOOD SBBOB; BLOCD
PtlSBl! TOeOSLaVIl; CRLOBIM1BD
BTDBOCIBBOBS
a) saaplea la »bich p, p'DDT iaa
po*ltl»«ly Identified
b| ill aaaplea
poataoctaaa. Virginia Stata Badlcal
Bxaalaeca Offlc*, 1972. abort *5X
fcoa aklt* aala*. 301 fcoa black
aalaa. 15* fcoa (kit* f*aal*a, 10X
fcoa black faaala*.
CBLOIIIB OBG1BZC COBPOOID3; CDT; DDB;
DIBLDSIB; VXBQZBZa; BLOOD;
CISTICIDBS; POLTCBIOttHTBD
EZPRBBILS; BBUCBLOBOCTCLOBMaBS;
BIPTICILOB BPOIIDB; CRLOBIBltBD
B1DIOCIBBOIS
Blgkac paccantagaa of ocganocblocla*
ina*etlcld*a and PCB'a In allk of
actbara 20-29 yeaca tban 30-29,
althoagk tba foraar kad lone levela
la plaaaa. Ovecaeigkt «oaen had
lover level* than noaea of nccaal
aalgkt. Baaldaaa coae*ntrat*d In
aitcactad llplda of plaaaa and allk.
lacaall voaen 2-* daya aftac noraal
delivery.
PISTZCIDBS; BLOOD PLISRk; BI1K:
POPDUTZOB BXP030BB; ISBlBt!
CBLOBZB1TBD BTDIOCIBBOIS; LZIZDS;
IBB; DDT; DID; ODB; POLTCELOiZlaTSD
IZPBBBTLS; BEPTaCRlOB BPOXZDI:
BIItCRLOBOCTCLOBIZIBB
a) Patlaata en b*aodialT>la for
chronic canal failure, pcadlalyala
b) Patiant* on haaodlalyala foe
chronic canal tailor*, poatdlalyala
c| contcola
Patiant* at Charity Roapltal IB «••
Oclaana, Loalalana, and r«lati»«* of
patlaata (eontcola) or vockaca at the
aalt (control*) .
EISTICZDBS; BLOOD PLaSBt; LOOISIkla;
CCE; DDT; PBRaCRLOBOPBBllOL
B9PBBBBCB
Balnar. B.
Keaatkackar. B.
Stlpcerlc. B.
Stafanac, t.
1977
-
criffltk. P.O., Je.
Blank*. B.T.
1975
. _
Pollakak. Z.I.
Boa, R.
laaaecaaan, n.
cacoa, S.
•aaaecaaan. 0.
Leaeach, C.
1977
Pearaon, J.E.
Scbaltz, c.D.
Blvera, J.B.
Gonzalez, r.n.
1976
-------
Bthana, l,1,1-trlchloro-2,2-tla(p-chlocaphanTll- (S CII
E»ni«n«. 1,1'-(2,2,2-trlchloio«thrlldan«)bla(a-chloro- (9 CI|
•0-29-1
CU-H1-C15
IK 351.50. nt 108.5-109 C. BP 260 C, IV 1.5I10|B-7) » 89 at 20 C
(COITIIOBD)
TISSUE
2201
flood.
•arm
220*
Blood.
•hole
2205
Hllk
2206
Bilk
2207
Bilk
B IPO JOB! SOOTB
IIILTTICIL
BETCOD
OC-BC
CC
GC
GC
OC
nc
BOBBEB
or CASES
a) 8t
b) 56
c) 36
d) 11
a) 9»
fl 96
26
57
29
50
BklGE
a) 5-68 ppb
b) 5-21 ppb
c) 5-19 ppb
d) 5-6 ppb
a) 5- It ppb
f) 5-68 ppb
lot glTen
0.0 1-0. 8t ppa
lot given
2.3-138.3 ppb
•
(IBXT
•Ell
a) 17.9 ppb
b) 9.« ppb
c) 9.5 ppb
d) 5.t ppb
a) 7.7 ppb
t) 8. 1 ppb
0.030 ppa
0.09 ppa
0.0122 ppa
17.89 ppb
.
HOB)
email uroBamoi
a) Balea, hoaaaholda olth on« or nor*
•aabers in paaticida indnatry
t| Paaalea. hoaaaholda «lth ena or
aera aaabara in pettlcide Industry
c| Balas, facaa nhera paatlcidea «*ra
d) reaalaa, faraa nhare p«aticid«a
a) control* (aala)
O
-------
Itkaae. 1,1.1-triehloEO-2,2-U.e{p-chloropBenyl)- (• CI)
Benzene. 1.1'-(2,2,2-trichloroetkrlla'ene)ble(a-cnloro- (9 CII
50-29-3
C1«-B9-C15
!• 35».50. IIP 109.5-109 C. BP 260 C, TP 1.5X10(1-7) •• Bg at 20 C
(COITIIOED)
TISSOI
2208
Bilk
2209
•Ilk
2210
•Ilk
2211
Bilk, fat
2212
illlk, fat
EXPOSOn 100IB
imnxcu
BBTBOD
ec
oc
oc/as
oc
IOHBB1
OF CaSES
2 Of 51
•) 23
b) 20
c) 12
4) to
•1 38
f) 19
91 20
k) 19
•) 10
b) 25
C| 35
11 10
•1 20
f) lot
given
*) 1«
b| 5
cl 16
UKB
lot given
•) Bot given
b) lot glw«
c) lot given
I) lot given
•1 lot given
f) lot given
g) lot gl»«n
b) lot given
a) lot given
b) lot given
c) lot given
4) lot given
e) lot given
f) 1-21 ng/9
lot given
t) lot given
b) lot given
c| lot given
(ISIT
ran
... --
0.008 ppe
*) 1.3 ppe. fat b«»i«
b) 1.* ppe, fat bail*
c) 1.3 ppe. fat baels
41 0.9 ppe, fat baele
el 0.9 ppe, fet baele
f) 0.8 ppe, fat baele
g) 0.9 ppe, fat baele
k) 1.0 ppe. fat baele
a) S ng/g
b) 7 09/9
et 6 ng/g
41 5 ng/g
el a ng/g
O 6 ng/g
2287 eg/kg
a) 1.3 eg/kg
b) 1.0 eg/kg
cl 0.63 ag/kg
PtOBI
GIIIUL XirOlUTIOl
Iaa4oe eabjact* of greater St. loole.
10, eetcopolltan area.
PIStlCIDIS: CB10IXII OM1IXC
COBPOOIBS! DM; DOti DIELDBII;
BIUCBIOIOCTCUBnllB: BUT1CHLOI
BPOXIDEI "III: BISSOOII; COBUBITIfB
IflLOMXOIS
a) 1970
t) 1971
e| 1972
i) 1973
•I 197a
f| 1975
g| 1976
kl 1977
Batleate4 fro* graph
Bctkece In Oeaka Pnfectace
SIPHBITL COB COORDS; CBLOBIBB OBGalXC
COIPOOIOSt DOI; DDtJ OXBtOlII;
BIHCBIOBOCIC1OBII1IB: JlPtli HUK;
COlTCalOIIItTID BIfBBITLS
a) Baetecn Cana4a
b| Quebec
c) Ontario
41 Central Cana4a
e| lectern Canada
ft latloaal average, saeplee above 1
og/g
latlonal Server. 1975
BIPHBITL COBtOOIDS; CtltOi; CHLOBIIE
CIGIItC COBPCOIDSJ DOI; DDT;
OmDIH; BIPTICBLOB BPOXXDI;
BmCBLOtOBBIHIt;
BIXtCBLOIOCIClOBtXlIB: SILK;
lOltCBLOl; OXTCILOIDalB; PESTICIDES;
COITCBLOIIIlTED BIPflEIILS;
ECITCBIOIIIHID TBIPBBITtS
85 eaeplee-eack ie average fro a 20
eotkera. Bilk obtalne4 free lactarla
In Slovakia, 1971-1973. Taloee
•atlaated free graph.
CISTICXDISi Bill; FITS;
ciBcaosLoviKii:
BIMCBtOIOCTClOBEXtlli DDT; CDE;
BIXlCflLOIOBIBSBIE
a) Pooled eaaplee, 1967
11 Pooled aaaplee. 1968-1969
c) Pooled eaeplee. 1971-1972
Boaen In Stockkola, S«e4en
PISIICIOBS; POPDHTIOI EIPOSOPI;
BILK: DDT: DDB; BXOtCCOHOLlTtOli
S1BDEI
1ETE1EICE
Joneeon, T.
tie, 6. J.I.
Irabrister, J.
(ettelhat, L.L.
Dr acker, B.
1977
Tekaekl]!, T.
••tanebe, I.
Kavabara, K.
Toehlda, s.
Hod, S.
faknefclea, S.
Kaekleoto, T.
Kovaaa, K.
Kanlte. ».
1979
Bee. J.
Deviee, D.J.
1979
Siokolav, t.
Boelval, L.
Oknak. J.
Ba4arlc, i.
1977
Raetoo. G.
197a
N5
NJ
-------
Btnana, 1,1.1-trickloro-2.2-bis(p-chlorophanTl)- (4 CI)
Baanna, 1.1'-(2.2,2-trichloto«thTUd«n«) bls(«-cliloco- (9 CT)
SO-29-1
CU-H9-C15
a« 35*.50, BP 108.5-109 C. BP 260 C, »P 1.5X10(E-7) •• 19 at 20 C
TISSOE
2213
Milk, tat
221*
•Ilk. (it
2215
R Ilk.
ihol*
2216
Bilk.
•hole
EXPOSOIB MOTE
IflLTTICkL
BBTEOD
GC-RC
GC-RC
OC-EC
ec
BORBBI
or C»SBS
•1 S3
b) 33
•1 3«
b| 6
22
«> 1*
b) 5
c) IB
UIGE
a) Eot detectable-11.25
ppa
b) Trace-8.35 pp«
a) 0.3«-18.*S ppa
b) 0.26-0.53 ppl
0.002-0. 025 pp*
•1 lot gl¥«n
b) lot glrm
c) lot given
B81I
. .. . . _
a) 1.1* ppi
b) 0.«37 pp>
a) a. 25 ppa
b) 0.390 ppi
0.010 ppi
a) 0.0*0 ag/kg
b) 0.030 «9Ag
c) 0.020 agA?
GtlltlL IIFOII4TIOI
a) 1966-1970 atadf
b) 1977-1978 ctady
1966-70 p«tl«nt« (OnlT«»ltr of
llb*cu BoaplUl), 2-10 flay*
poatpartaa. 1977-78 patient* (public
aaalth offlcaa at Ubarta), 17-309
daya poatpaEta. Kcald«nc««, Edaonton
oc Hbarta.
RILK; PESTICIDES;
RmCRLOlOCICLORKHE; ODD; [DE; DDT;
DltLDIXI; REPTaCBtCR EPOnDBj
BIUCBLOIOBSISIIE; CIIIDA;
lOlKBLOIIRITID BIPHBIILS;
CCRPtlaTIVI ITaLOkflORS
a) Hlgk paatlcld* uag« ac«a
b) to* paaticld* aaaga ar«a
laMn ll»lng In Starkflll*.
Blaalaalppl (lo> p«atlcU« aiagO and
D«lta area (klgh paatlcld* auga) .
SaapUa In 1973-1975.
BIlC; PESTICIDES! DDE; ODD; EOT;
amcHLOiociaoRixm: HEPMCBIOB
IIOIIDB; OXICILOlDalli DIELDtlBj
BISSISSIPPIt COBPIMTITE ETlIDlTTOIS;
BClSOBEBBR IBTRODS
Sncray, ••atacn a«atcalla, 1970-1971
22 naralng aothara, «t 46-66 kg,
living »lthln a 30 ai cadlaa of
F«rtn, ••atara taatcalla
8IK; PESTICIDES; aOSTMtll: DDT;
DIE; DIEIDRII; RIXlCltOIOBEIZBIB
a) Pooled aaaplaa, 1967
t) Pooled aaaplaa, 1968-1969
e) Pool«4 aaaplaa. 1971-1972
loam In Stockholn. S»«dan
PESTICIDES] POPOIITIOI BXPOSQ1B!
BlttJ DDT; DDE; HClCCOBOHtlOB;
SIEDII
8EFEBEBCE
Corrla, l.a.
RaUa, T.«.
B»ltkt*ltz. «.E.
cunlnghan, 8. B.
Bran*, e. I.
1979
Barnatt, 1.9.
D'Eccola. a.J.
Cain. J.D.
Urtkor, B.D.
1979
Stacaj, C.I.
Tkoaaa, B.I.
1975
la at oo, 6.
197*
to
10
ro
-------
Bthtt*, 1,1>1-trtohlaco-2>2-M.«(p-n«tko(Tpk«arl)- (* CIJ
B»MM. 1,V-(2.2,l-tclehlora«thrlia«M|bl«(«-MthoxT- (9
7J-«3-5
C1S-B15-C13-02
n 3«5.SS. 8* 78-78.2 C (UBCtpkic ccy»t«l>) or 86-88 c
tissoi
2217
•load
BXfOSUD Butrri
tnLTTICU.
•map
8C
IB8B11
or CISBS
») 13
b) M7
UI6S
•t 10-38 pptl
b} Bat 9l»«»
IUI
•1 19 rob
b) < 1 ppb
SBIIMt IIFOBMTXOI
-
i) S*ipl«« ID >kleb MtkoxyeUoE «*«
poittlNlf 14«tifl«d
b| HI iMplu
re*taoct«». Ticjinlt st«t« tadlctl
CmlMn OKlc*. 1972. tboit «S«
ttam «klt* ••!••. 301 fro* black
HlU, IS* (CO! «kit> f««l«l, 10S
Icei bltct f ••*!••.
cnoiin oioiiic coiPooiDS; cut: DDE;
CHUBIB; flBeilll; BLOOD;
EISnCIDBSi POlTCBlOBIUfBD
eXMBBTlS; BKiCBtOlOCtClOB JUIB;
BtPTtcnoB BMzns: CHLOBIIIIBD
BIDBOC1BBOIS
BirBIEICB
Eriffitk. r.o., Jc.
Bluk*. B.V.
UTS
ro
ro
-------
EthanoL, 2-(2-(0-(p-chloro-alpha-phanylbBniyl)-1-pipecarinrl)ethoxy)- (B CI)
Itaanol, 2-<2-<»-<('-ctiloropb«nyl)ph«nyla»thrl|-1-pi.p»railoyl)«thory)- (9 CI)
«e-S»-2
C21-B2f-Cl-l2-02
III 37».12. fit 1°3 c (dlhydrochlocid*)
TISSUE
221?
Blood.
plama
EIPOSORB BOOTS
IngeBtlon
kntTTICtl
HRtOD
GC/HS
KOSBEB
or CASES
»
III6I
20-35 ng/al
m»
lot applicable
G8IIBAL IIPOIltTIOl
Bang* of •••n« 1 and 8 he after
100-ag tablet a» tbe hydcochlocU*.
Data (It on«-co«pactaent op«c aod«l.
locaal folantMra, fasted otwrBight.
CBOOSj D106 TflllAFT: BIOOD PUSU;
BHSOBEBtlT BETBOD3; I DOITS:
HElaBOLISR; CBIOBIIB OiSillC
CCBPOOIDS
BBfgBEICB
Fonda, R.G.
flobbs, D.C.
Stacbaagh. J.
19^9
E.
NJ
-------
Itkanol, 2,2.2-tticaloro-
115-20-9
C2-B3-C13-0
It U9.«2, St 18 C. BP 151-153 C
TISSOB
2219
Blood
2220
Blood,
2221
Blood,
plaaaa
2222
Otlna
SXPOSIIB BOOTB
Ingaatlon
Ingaatlon
Inhalation
I
1I1LRXCM.
BITBOD
. _ ..
OC
GC
Colotlaattr
-
IOBBES
or cisss
16
1
1
a) and b|
19
c| 9
B»OE
0.6-133 ng/al
a) 1*1-200 agAl
b) 81-100 ng/al
c) 330-«5 ng/al
a) 2-0.* ag/1
b) 0.8-0.3 ag/1
c) 7.8-5.3 ag/1
d) 6.2-6.2 ag/1
a) 0-8* ag/g eteatiaine
b) 56-280 ag/g creatlnlne
c) < 2 ag/g cieatlnlne
mi
}«.« og/al
a) 165.8 ng/Bl
b) 86 og/al
c) lot applicable
a) 3.6 • ot - 1.6
ag/1
b) 1. •> » ot - 0.5
ag/1
c| 8.5 * ot - 1.5
ag/1
d) 8.2 » ot - 0.6
ag/1
a) 3» ag/g ctaatlnina
b) 1*5 ag/g
ctaatlnlna
c) < 2 ag/g
ctaatlnlna
QBIEBll XBFOBIiTXOB
Death caosed by dtag coablnitioaa.
lacotda of 1239 daatha In 0. s. and
Canada. In all, dlaxepaa ot Ita
aatabollta vare praaant In tba
tlasaaa and, in aoat caaaa, BOOB than
one dtag «aa foond. ages: le*a than
S-gtaatat than 65 yt. Blgh fcagaaney
of aalclde. other data available.
Falaonaty and visceral conge rt Ion
aoat coaaon poataoctea finding
DBOOSi DBOO 1BOSI; CII1D1; OBXTBD
SUTB5; DHB; SBDtTXTBS; BTPWTXCS;
fSYCBOTlOFIC DBOQS; BLOOD! LXfBl;
IIDIBTS! IICQBOLIC BBTBBIOB5;
fOBBBSIC BBDXCXBB
•1 Irterlal blood, doting « he of
kaaodlalyala atartlng at 21.5 ht
b| Tenoaa blood, doting * ht of
haaodlalysis atattlng at 21. ! ht.
tvarage clearance «aa 122.8 il/aln.
5.21 g reaoved
el change 2-90 ht aftat Ingaatlon.
Ondatactabla at 131 ht
38-yt-old white aoaan with long
paychlattlc hlatoty adalttad aftat
ingesting 38 g chlotalhydtat*.
> 2 ht after doaa: cyaaotlc, deeply
eoaatoaa, hypotansive, respiratory
diattaaa, abnotaal BIG.
8IPIOTICS; DBOGS; DIOQ aBOSB; BLOOD
CLftSBl; CllItOBIXt; LtflGB;
ftoiotoaxc BiixristiTiois
a) IS ag/kg chloral hydtata
glocotonida conjogata level*
c) 22 ag/kg tticlofos, glacoronlde
conjugate levels
e) 15 ag/kg chlotal hydrate, free
fota leva la
d) 22 ag/kg tticlofos, free fota
let el a
langea are aaana at about 1 and 6 ht.
Beans ate peak saana. lo dlfterencea
tatvaen dtaga at any tiaa (P> 0.051 .
Gaattolnteatlnal gaa and flataa
doting chronic therapy.
SIDHItBS; BtPIOTICS; OBDGS; DBOG
TBIRkFT: BBTlBOLXSa; BSTIBOLITBS;
BIOOD FL1SBI; COHPUHITB BTILOlTXOIS
a) Horning aaaples, exposed wtkets
t| tftetnoon saaplas, exposed votkets
cl Conttola
Ciposore levels of tclehlotoathylene:
17C-»20 ag/ca a
CBLOIIIB OIGIIIC COSPOOTOS; DBIIE;
BtHBOLITESi OCCOPITIOIU HIIIBBS;
OBIO
. ,.-- —
BBraBBBCB
Flnkla, B.S. .
BcCloakey, K.L.
Goodaan, l.S.
1979
Stalker, I.E.
Gaabartogllo, J.G.
PokOBitso, C.J.
langkton. J.L.
Banat, L.I.
1978
Sellets, E.B.
Lang-Sellets, H.
Koch-feser, J.
1978
Lovry, L.K.
Tandetvott, B.
Polakoff. P.L.
197t
-------
Ithtnol, 2.2".2'•. 2' • •- ((*.«-dlplp«ridinoprcliido (5,»-d) prcl«idiM-2.«-dirl| dlaltrUo) t«tn- (8 CII
Ethinol. 2.2<.2".2<<'-((«>S-di-1-plp«rldin7l.pTrli.ido(S.«-d)prriBldliM-2.6-dijl.)dli>ltril.o ) t«tctkla- (9 Ct)
56-32-2
C2«-B«0-I8-0«
HI 50«.62, HP 163 C
1TSSOI
2223
Blood.
pla«M
CXPOSU1E BOOT!
.
ingvstloD
HHITICIL
RETROD
riioroi«trr
IORBBI
Of CIS8S
«
BHGE
_. .
t) "2-1,606 ag/ml
b) «-1,019 nq/«l
«)
•I
bl
nq
«25 » or - 2*6
/•I
61« » or - 211
CEIEIll IIFOUITIOI
a) P««k - J br «Ct«c first of 3X75 19
doM«/d«y
t) P*ik - 1 he «ft«r first at 3x7S
dc«««/d»r of drug • 325 mg atplcia
8«>na and s.I.
fliqhcr l«t«li «ft«t «*cond dc«« of
dcaq » asplcio
Other dltt t?lll«bl«.
Ktlthr »oloot«BC«. 69-79 kg
DIOGS; DBOG IBK14PT: COIPllltlVI
IlktOITIOIS: BLOOD PttSU; BHIESOTl
nntstct
Tyc«, c.R.
rut«r, T.
0««D, C.I., JC.
1979
.
10
N3
-------
Bthyl alcohol (S CI)
Itkuol (9 CD
6«-1T-S
C2-B6-0
II M.07. St -117.3 C. n 78.32 C. ft «0 » 19 at 19 C
T1SSOB
222*
Blood
2225
Blood
2226
Blood
2227
Blood
222B
Blood
Bifosvn IOOTI
Ingest loa
Xngertlon
Indention
ailLYTICIl
imoB
-
BBSTUtlc
GC
Eniyaatlc
GC
•DBBEB
OF CUBS
29
2
331
21
1
UMB
13«-*88 ag/dl
O.OS3X-0.0961 (I/T)
0.01-0.71 ag/al
•I 37-431 19 t
b) 39-»22 *g %
515.0-115.2 ag/dl
(HIT
rat)
lot given
lot applicable
0.1* 19/1!
91 192. «7 19 *
b) 205. 2* 19 *
lot applicable
MOBI
GEItllL XBfOIBaTXOB
Initial levels. 21 exceeded 300
a 9/41.
26 aales aid 3 feaalee, 17-60 yr of
ago. treated for ac*t« «th«ncl
(todkal polaoolDg.
20 MC* coiatoa* oa arrival, 9 mro
•icltcd and aggmain. rkyalcal and
aantal control regained attor 2* kr.
(OLtlD; HCOBOLIC BBTBItOBSj B10OD
Radical oiailnar cuu of death* froa
litentloaal or accidental 00, or
andeteralned or natural caaaa.
Diass; tatofsiBSi OIVEHDIIBS;
SniCIOB) BtOOO; DBIBB; LIfBI; BILE;
DIDO 1B05E
Deatk caaaed by drag conblnatlons
leeordB of 1239 deaths In 0. S. and
Canada. In all, dlaxepae or Its
aetabolita aero praaent In tba
tiaaaea and. In ao«t caaaa, tore than
one drag «» foand. tgea: la* than
5-greatec than 65 yr. Ugh fregaency
of aalclde. Other data available.
(alaonary and vlaceral congeatloa
loat coaaon poataortea finding
tioasi osoe JBOSB; ctitot: onTBD
£T»TBS; OMB: SBDITITBS; a t no tics j
ISICBOTBOFIC DRD03; BLOOD: LITBB;
IIOBBTS; tICOBOlIC BBTBRiOISj
fCBBBSIC BBOICIBB
a) By oc
b) By alcokol dehydrogenaae aethod
Bange of aeane baaed on triplicate
deteralnatlena. Tao aethoda highly
correlated, r«0.997.
Pcataortea a[eclaena obtained In 1977
aad 1978.
ItCOROLS; DBOBS; IOTOPSIES; U.OOD;
IIISOBBBBBT BBTBODS; COBVaBlTITB
BULOITIOIS; BBIYBBS
0 and 16 hr after adalaalon ! hr
attar conaaalng 30-60 al vodka
Clearance linear
18 ao old tilth overdose. Charity
Boapital of Loalslana.
Irritable, then coaatose, no deep
Fain response, negative cornaal
reflex. Regained conacloaaeess 10 hr
alter adalsaloa.
ItCOROLS; CBILDBH: UCOBOLIC
IlTntOBS; BLOOD: DBOOS; DBOC tBOSE;
LCOISIkll
BEfERBBCB
Bogaax, n.
Pack, J.
Stasko. I.
1977
Slek, t.J.
1978
Pinkie. B.s.
Bccloskey, K.L.
Soodaan, l.S.
1979
Poklis, I.
Backell, H-i.
1979
Ragan, r. «., Jr.
Saaaels, n.S.
Bite, s.l.
1979
10
-------
(lookol I" CI)
ItkMol (« Ct)
«-n-i
CI-M-Q
ill M.07, HP -117.) r, «p
r, TP «o » no tt 11 C
"flSSBi —
Head
2130
(load.
pltlit
1111
Hood.
plaaai
„ - -
iiwsBln ISBri
Ingcotlon
Tngaitloa
Iteration
. .._..._.
NITROD
or
oc
KUNDtlN
nr C13BS
1
10
.
filial
0.1-0 ag/al
a) 11. 1-4. 1 ital/1
b) 13-1.1 Hal/1
10-180 19/100 il
RHi
lot applicable
» lot
nlllllL IIPOI1ITIOI
1.* »n.l n he ttt«c 0.« g/ka ««
cocktuLl. Inltltl flint, 0.2 ig/«l
nt a. if he. la ilgnlflctnt
i1lrr*r*nc« In •!••( n «lr«k« •ff*otl.
««iltk« adult. socUl dclnktr (<«0 g
•loakol/nk) . Pasted btfor* ind aftcc
dOM.
tlCOHOLSl »OST«»lIl| BtOOOl
flTHOttSNl COBPH*Tt»« ITtLCKTIOIS)
kCOLTSl ItCOBOttC llflltOISl IIXTRIS
a) lUani 10-1(0 iln, O.it g/»g
•tkaiol plua placvto
t| Man* «0-1«0 tin. o.«» a/kg
•tkanol, 1 ig cl*a«itln*
Ptak «t ao ain.
15 •«!• and 15 f«>.l. koaltkt
folunt«ca, «g«> 10-21 ft.
alngli tk«cap«atlc doaae of
OIOOS | Dinfl TNIItPTl SID»TI»15|
itOlTSl tOSTIILItl ILOOD PltMIl
llOtOtOOIC ItllPIITITIOISl
PI1CROTIOPIC DIOOI) ItCONOLtt
IIVIItaMl COHPklkTIVI ITklDITIOIS
• at 13 pttUnto adilttvd oa U
oeoailoa* aftvc otacdona of
eklotntklaiela.
1!-^' fc old patlanta
ocad* l-» caaa In 5 eaiaa( pn»uaonl«
In 1 oa».
DlOaSt HtHOTICSl 0109 ttOlll
klCOIOUl BIOOD PltfNtl CHI
ITSTOIllSl ICOTIIID
""""C*
Kadaan, D.I.
• oaal, I.
1«ao
Prank*, n.n.
H*nil«r, »..'.
T*o, I.R.C.
Ullngnortb, d.l.
Stoact, H.J.
JatvU, D.I.
NJ
00
-------
itkylm* flrool (I CQ
1.}-m«M4lol (t CI)
101-11-1
ca-M-oi
II M.l. It Itl.S C. ft 0.01 •• *1 >t 20 C
TIIHI
•loot.
grin*
HKIOU I00TI
Xifoitlot
iBfOltlOt
tmTTXClL
•nioD
iSSiii
or cms
itni
i) lot applletbl*
b) lot •pollotblo
c) lot tppllotbl*
lot cppllotblo
iiii
b) IT* ia/1
a) •• K/l
OIIIML IlrOINHIOl
•I « kr «ft«r l*9*itlo>
b| » kc «tt« ln««itlot to* • kc of
kiiopcctailoi «ltk «ctl*tt«4
ekueoiV. 100 il/iii
e| 11 kc «ft«r Inanition
lt«tclo l»*i« ni t4ilnl«trttlon of
•tk*KOl ((.0 f/kt If) ««t« pwtocnd.
l>twt*< (ikkna
tiotnt ot *tkri««« «iroox.
ttln In >pp«c «b4on« *t >4iU«lon.
Clll HiltontM| klCOIOUi LtltOI)
Oftlll I1000 Pllllll lOOltJ
•ntttlon tatltf •• ht ct
k»op«[(iiloB, 100 il/ilB. «ltk
•ctl**t*< aktrootl, *tt*r lio*itlo*
of «tikno»o n
•toint at *tkTl«l« 4ITcol.
Piln it lpp«t *b4onn tt lAiUalon.
rill c«oot«cj.
CIS* IttJTOKIll! HCOHOLS) UlkOI)
vniii ttoot (Liinii koatts
iinnici
a*Bgit«c, I.
rnnw, J.l.c.
<• atoot, a.
l*«0
lt*9it«c( I.
Fc«n«>, J.l.c.
<• Ocoot. a.
l«so
-------
*. trlchloro- (1 CI)
Jth«n«, trlcbloro- (•» CI)
79-01-6
C2-B-C13
gl 131. «0. DP 73 C, BP 6^.1 C. »° 100 » Hq »t 32 C
rrssos
2231
HdipOM
223S
Br«in
2236
K14n«T
2237
Ltrac
EXPOSDRE BOOTB
lltLTTICtl.
F1BTROD
5
or
50BBES
OF CiSBS
HBtl
CBICBIL
IfTIBC; OCCOPtTIOIlL BiZiRDS;
fCPOHTIOl (IPOSOSI; fOODS;
CIRCII06ER; miBOlXTSSi »IE£THETICS;
IltER; JDIPOSB TISSOE; KIDIB1S; BB»I«
1ITIEI: OCCOPtTIOIlL HlXtlDS;
COP01ITIOI JIPOSOBE; FOODS:
CtRCIIOOBII RETtEOLITCS;
tOIPOSl TISSUE; KIDIETS; BRtll
IITIEI; OCCOMTIOItL RttllDS;
fOPOtlTIOI tlPOSOlE; rOODS;
arriBoims; HEITBBTICS;
tDIPOSE TISSUE: KIDIETS; BRtll
Bt«le.
RIflEI; OCCDP»TIO«»L RttllDS;
CCPOtlTIOl (tPOSOIt; rOODS;
CIBCIfOOBI; HETAEOlITtSi tIESTlETICS;
UTEt; IDIPOSB TISSOE; KID1EIS; BBJII
REFEREIICB
•at«r«, E.8.
G«r
-------
Itkylene, 1,1-dlchloro-2-(o-ckloroph*nyl)-2-(p-chloropheayl)- (8 CI)
Beaxeae. 1-ckloro-2-(2,2-dichloro-1-(«-chloropheoyl)etheaylJ- (9 CX)
3*2*-82-6
C1«-B8-d«
BB 318.03
TISSOB
2238
adipose
2239
Idipoae
22*0
Blood.
plaaaa
22*1
Bilk
— .1
BIPOSOBB BODTB
1R1LTTIC1L
IBTBOD
OC-BC
OC-BC
OC
6C
BOBBBB
or CISBS
II 26
b) 22
e» 27
d| 18
•) 18
O 13
a) 20
b| 16
c) 22
d) 1-»
29
29
BIBOB
a) <0. 0001-0. 0250 ppi
b) <0. 0001-0.09*0 ppi
c) 0.0070-0.2080 ppi
A) <0. 0001-0.0350 ppi
*) <0. 001-0. 0795 ppi
t) 0.0150-0.1818 ppi
a) 0.0007-0.0300 ppi
b) 0.0030-0.156* ppi
c) 0.0030-0.0690 ppi
d) 0.0033-0.0309 ppi
Bot given
Bot given
(BBXT
RIM
a) 0.0090 ppi
b| 0.0164 ppi
e| 0.0532 ppi
d) 0.0126 ppi
e) 0.0211 ppi
f) 0.0533 ppi
a) 0.007* ppi
b) 0.0170 ppi
c) 0.0135 pp*
d) 0.01*8 ppi
0.0112 ppi
0.0095 ppi
1
FIOB)
QBBBBaL IIFOBB1TIOB
a) Rales - stillborn
b) Biles - 0-11 10
c| Bales - 7C» yc
d) resales - stillborn
e) resales - 0-11 10
f) resales - 70* yr
Levels see foe o, p'-DDT»o,p' -DOO
Data available foe intermediate age
gcoips.
litopsy speclsens, 1967-1971, fcos
laraelia vitk no known occapational
eiposace.
fISTICIDBS; IBSBCTICIDBS; CBLOBIBE
OIOIBIC COBCOOBDS; DDT: DDE; ODD;
DIILDIZBi BEtTtCBLOB BPOZZDB; IDXPOSB
1ISS0BI ISBlILj BBUCBLOBOCTCtOBBXaRE
a) 0-4 yr old
b) 5-2* yt old
c) 2S-«« yr old
d) (5» yc old
Bales and tesales
Other data available.
latopsied tissue (1969-701 froi
individuals vith nc known
cccopational exposure sho had lived
in the Kaapala region of Oganda.
FESTXCZDIS: CHtOIXBS OBQ1BZC
CCBPOOBDS; DCT; OXnOBZBl BBETICBLOB
HOXZDBl 1DZPOSB TISSOB; 001IDI;
BIXlCBLOBOCTCLOaiXlBB: ODD; CDB
Higher percentage* of organochlocine
insecticides and PCB'i in ailk of
aethers 20-29 years than 30-39,
although the focser bad lossc levels
in plaaaa. Overnight noaen kad
lower leveli than woien of noraal
•light, Residues concentrated in
extracted llplds of plassa and ailk.
Israeli woaen 2-* days after noraal
delivery.
FtSTZCIDBS; BLOOD FUSIU; RI1K ;
PCPOlaTXOR IIPOSOHE; ISIaBL;
CBLOIIEITBD BIDIOCIBBOBS; LI (IDS;
IGB; DDT: ODD; DDB; POLTCRlOnBITBD
BZPRBBTLS; BBPTaCRLOB BFOZIDI;
BlIaCRLOBOCTCLOBIXIBB
Blgher percentages at organochlorlne
Insecticides and PCS'* in ailk of
• etkers 20-29 year* than 30-39,
althoigh the foriec kad lowac level*
in plain. Overweight vosen kad
Icier levels than vonn of ncrial
•eight. Beslduea concentrated in
eitcacted llpldi of plain and ailk.
Israeli «oa*n 2-* day* after noraal
dtllvery.
PESTICIDES; BLOOD fLlSBl; BIIK;
POPOLlTIOB EXPOSOIC; ISBIBL;
CBLOBIBITED BIDBOC4BBOBS; LinDS;
>Ct; DDT: DEC; DDB: POLTCRLOFIRITED
(IFRBWTLS; BtPTtCRLOB EPOIIDI;
RIItCRLOBOCTCLORIXIBB
BBRBBBCB
•assecunn, R.
Toiatis, t.
Basseriann, D.
Day. B.B.
Groner. T.
Laxarovici, s.
Boaenfeld. D.
197*
Bassecsann. R.
losatis, L.
•as*ernnn, D.
Day, B.B.
Djavaherian. H.
197*
Pollskuk. X.l.
Ion, R.
(assernann, H.
Cncos, S.
wasseriann, D.
Leiesch, c.
1977
Pollahok, Z.I.
Bon, II.
Baneriann, H.
cucos, s.
Basseriann, D.
Leneich, C.
1977
NJ
U>
-------
Uhylen«, 1,1-4ic»loro-2- (o-chlocophenyll -2- (p-cnlocophenyll - (P Ct)
e«nz»M, 1-chloro-2-{2.2-dlchloro-1-(a-chlorophenyUelheoyl)- (9 CI)
3i««-82-«
CU-H8-C1H
11 318.03
TISSUE
22*2
Bilk
EXPOSOBB ROOTB
'
.
tRaLYTICal
IITHOD
.
GC
TtC
»DBB!R
OF CaSSS
30
BHIGE
1.6-03.8 ppb
(COITIIOBO)
18.02
GEIISH
lllk aaaplta, hoipitala In aibsn
Oalo. » aaipl«i (to* Ralllngdal, a
tallay In aonthtcQ Kotnay. K>
cccupatlonal cipoaoc*.
BIH; TISICTICIDIS; HCTtTIOl;
CBtOlIHTED RTDBOCMBOIS; CB10BIIE
ciatnc coipoaiDS; PESTICIDE:; VOBRAT
BEPEPEUCI
Eakken, t.F.
Selp, it.
1976
-------
Etkylene, 1,1-dickloro-2, 2-bl»(p-ckloropfcenyl)- (8 CII
Baazeae, 1,1'-
OJ
-------
*. 1,1-dichloro-2.2-bl«(p-chloroBh«nTl) - (BCD
Ban«»n«. l.l'-tdichloroethonjlldanalbiMa-chloro- (9 CI)
72-55-9
CU-BO-CU
91 318.02. If 88.0 c
(COITIIOBO)
TISSOB
22»1
adipose
22*8
Idipoie
22*9
adipom
2250
IdipOM
EIPOSOIE BOOTS
IBhalatloa
Xigection
IHLTTICM.
HETROD
GC-BC
GC
OC
ROIBSB
OP CISSS
al 26
b| 39
o| 122
d) 99
•) 151
O 70
268
73
al 33
bl 17
BtlGE
a) lot given
b| lot given
c) lot given
d) Bat given
e) lot gives
f) lot given
lot given
al lot glvea
b) lot gives
a) lot given
b) lot given
(1EXT
RCII
al 16.50 ppi
bl 22.52 ppa
c) 17.12 ppi
d) 17.55 ppi
e) 19.35 ppi
f) 13.31 ppi
2.80 ag/kg. Talne li
•edian.
a) 1.58 ppi
b) 2.15 ppi
a) 3.1 ppi
b| 1.8 ppi
PISE)
GIIIB1L IIPOHBITIOI
a) 196«
t| 1972
c) 1969-72 fCeialea)
d| 1969-72 (uleil
•1 1969-72 (Beslcan-aierlcan)
C) 1969-72 (ion Beiican-liccican)
Patient! undergoing elective sncgerT
IB 1969-72 in the lover Bio Grande
Taller °* *oatkea*t Texai.
P1STICIDES; DDT; lEPTlCBLOB IPOHDE;
CBLOBIIE OBGalZC CCIPOOIDS; 1DIPOSB
TISSUE: TEIIS; REIICBLOBOCTCIOREXIIE:
CCI; ODD; DIZIOIII; POLTCBIOFIIITBD
EIPBEITLS
Sgbcataneoaa ventral Cat ttoi the
Initltutai Cor Pathological Inatoir
and Poreniic Bediclne. 1971-1973.
PISTICIDES; BILK; UTS;
CXECBOSLOVllIa;
BIUCHlOBOCTCLOBHIlt; DDT; IDE;
BtXICBlOBOBtlZElE
a) let tieiaa
b| Pat tiaioe
Cata available Cor age aad i«c
qroapi.
lotopalaa Croi eabjeets < or • 82 jc.
(cci Porl and Jyvaakyla, Pin land
PtSTICIDES; DDT; DDE; TOLICHlOBIHTtD
IIPBEITIS; CELOBIIE OBG1IIC
COBPOOIDS: CBIOBIUTBD HIDBOCHBOIS;
ICIPOSE TISSOB; BBHB; IITBB;
aOTOPSIESS CCBPHITHE BTkLOlTIOIS:
ICE; S8I; PIIL1ID
a) Greenlanderi, 20-75 yr old,
aaiplei taken dicing acute
laparotoalea. Bigh«»t level* la 22- « 5
yt oldi
b| Denei. 1-75 yt old, eadden death
tv nicide or In a«to aceideiti
Bedlan valQea, baied oa llpid «t
let «t valve* available. Level* froi
other coutrie* Hated.
Gceenland nonindi*trialised area
Ceaiark ladictrUlixed.
IDIPOSE TISSOE; teij 10TOPSIIS;
CBLOIIIB OlCaUC COBPOOIDS;
fISTICIDES; COD: DR; ODE; OIELDIII;
BIPtlCRlOB EPOIIDE; POIICB1OHIATED
CIPBBinS; COBPallTITB BT1LOITIOIS;
POPDtWIOl EIPOSOIB; GIBEILtlD;
BBFEIEICE
Barm, J.I.
197»
Szokolay. 1.
Poaiial, L.
Ohnak, J.
Radaric, 1.
1977
Battila. B.I.
Ikkala, J.
Iioiaki, n.
Baatta, X.
Iritlla, 1.0.
1976
ClaiMB, J.
1979
tsJ
U>
-------
BtnylWM. 1,1-41chloro-2.2-b:U{p-ckloroph«nyl|- (8 CI)
Baanna. 1,1«-Cdickloroath»nylld»n«|bl«(«-ckloro- (9 CI)
72-55-9
C1»-B6-Cl«
HI 318.02. tf ••.« C
msni
2251
IdlpOM
2252
Blood
2253
Blood
225*
Blood
BIPOSOBB tOOTB
Ingaatlon
1IU.TTICU.
isnoD
OC
GC
IOIBSR
OF CISBS
1
•1 11
b) 1
1»7
•1 «»7
b| »97
•mi
2.2-2.6 ppa
•I lot given
b| lot applicable
8.»-118 ppb
•1 2-S5T ppb
b) lot gl**n
(HIT
an
lot given
al 225 ppb
b) 3,256 ppb
35.3 ppb
a) 25 ppb
bl 23 ppb
__-.
CIlIlaL XBFOBMTIOB
Conc«Btc*tiaa cang* 4-5* dayi attar
ingMtiOB of 170. 1 g in
dlchlofMthlon.
Salcld* att»pt by «2-It-old «al«.
SOICIDB; FtOUDlI »OtOPSIBS| BLOOD
3MOHJ tDtPOSE TMSOB: LXTBt; SILL
BUDPBII KIOIBTSi PBSTICIDBSi
OIBalOPBOSPlHBS; BLOOD; DDT; DDB;
DIILDBII; BZFTkCBLOB BPOIXDB;
BIZtCILOBOBBIUII; LaTtBBi IZOIOLOOIC
B1IIFBST1TIOIS; BtOlCCOBOLlIIOl:
BRlBOLITBS
•I Lif«tii* ra*ld«nti by cl*«r our
deduct DDT-ianofacturljig facility
b) Bld«cly »!• llfctlM c«*ld«nt of
«aa« ac«a
Linls 1» tins taoM of g««ral U.S.
popilation.
flab fro a Bantivill* Spring Iranck
•t«a of tha lannaan* ll*«c t«*ln.
l««ld«Dt> of Tclana. tlabaaa.
CCTi DDB; PISTICIDIS; RBIIBOIITBS;
II3BBS; FOODS; XIDDSnial roUOTXOI;
BLOOD; ILIBilt
1975 Tagoalatla «ct«y. TalvM ac«
foe aacaa 01 pi an a.
6! aalaa and 62 faaalaa, ag«d B to 92
jt (aaan aqa «2 yc| In Croatia.
BIXtCRLOBOCTCLOBHIIBi DDB; tDD; DDT;
PESTICIDES; BLOOD SMOB; BLOCD
FLaSIt; IOOOSHTH; CBLOBIIalBD
BIDIOClBBOIS
a) Saaploa In «hlca p. p'-ODE >aa
ponltl*«ly idutlflod
b» Ul sanplu
Foataoctaaa, Tlcglnla stat* Radical
Eiaainara OfClca, 1972. ibogt *5%
(con «hlt« aal«a, 30% (con black
aalaa. 15« (con «blta fanaUa. 10t
ftoa black taaalaa.
CBLOBIIB OIGIIIC COIPOOIDS; tDT; DDE;
CIILDIII; TIlGIBIa; BLOOD;
EISTXCIDIS; POLTCHIOniaTID
IIFBBITLS; BIZtCILOIOCTCLOHBUIB;
BIPTICRLOI ICOIIDB; CRLOBIII1KD
BlDIOCllBOIS
BBFBBBBCB
Da>l*a, J.E.
BnrqMt, I.
Frvad. T. B.
B«gn«, 1.
lorgado, C.
Sonnabom. B.B.
Tacla>ak, c.
1975
anon
1979
lalnac, B.
(caathackac, B.
Stlpcvvlc. a.
Stafanac. I.
1977
eciffith. r.D. , Jr.
Blank*. B.T.
1975
NJ
-------
tthylene, 1.1-dlchloro-2,2-bis(p-chlorophenyl| - (8 CII
B«nien«, 1.1•-(dlchloroethenylidene)bis(0-chloco- (9 CII
7J-55-9
cia-a»-cis
H« 319.02, IP «8.» C
(COITtlOED)
TISSOB
2255
Blood.
plassa
2256
Blood,
plain
2257
Blood,
serns
2258
Blood,
•kole
-
•IPOSOHB BOOT!
AIULTTICIL
HETBOD
GC
OC-BC
GC-BC
CC
8C
HOB 8KB
or cases
29
•1 23
b| 23
c) 1»
a) 86
b) 87
cl «6
dl »7
•) 187
f) 170
26
BUGE
lot given
a) lot given
b) lot glim
c) lot given
a) 16-209 ppb
b) 9-82 ppb
c) U-116 ppb
d) 7-28 ppb
•1 5-95 ppb
f) 5-105 ppb
lot given
(IBR
Mil
0.0195 ppl
a) 11.86 ag/1
bl 10.91 09/1
c| 13.28 agyl
a) 5«.8 ppb
b) 30.1 ppb
c) «8.a ppb
d) 17.0 ppb
•1 28.3 ppb
t) 2». 3 ppb
0.023 ppa
MOB)
GZIIBaL IIFOSaiTIOl
Rlghtc p«rc*ntaf«« of organochlorine
InmctlcldM and PCB'i In illk of
•oth«c« 20-29 T««» than 30-39,
although the foc(«c had lovci l«vels
In plaaia. Overnight voien had
lone level! than »o*en of necial
«itcacted llpldi of plaua and illk.
Kcaeli «oien 2-a days aftec noraal
lellvecy-
FtSTICTDBS; BLOOD FltSBl; BIIX;
FCPOL»TIO« IinsDBIi ISB1B1;
CBLOBIIITBD BIDBOC18BOIS; LIU OS;
161; DDT; DCC; DOB; POLTCBLOnilTED
EIPHBITU; BEPTICHIOB BPOIID1;
BtlkCHlOIOCICLOBHllE
a| Patient* on henodialreie for
chronic renal failace, predlalycis
b) Patient* on heeodialyeic foe
chronic renal failure, poetdialyeie
c) Control!
Patient* at Charity Bospltal in lev
Orleans, loaisiana, and relatives of
patients (controls) or vorkers at the
snit (controls) .
KSTICIDBS; BLOOD PUSHt; LOOT SHI »;
Dtti DDT: PBITaCBLOBOPBMOL
a) Bales, households tilth on* or sore
eesbers in pesticide industry
1) resales, households vita one or
sore sesbers in pesticide industry
c) Bales, fans ihere pesticides
freqoently used
d) resales, farss ohere pesticides
frequently seed
e) controls (sale)
f| Control* (feaal*)
Bean household ds*t resldaes: ».83
ppa (a-b), 3.28 pps (c-d) , and a. 37
pcs (e-f).
adslt residents of leld Coanty, CO.
PISTICIDBS; DDT; DDB; LUDHI;
BIPTICBL01 IPOIIDB; CBLORIR OMtlTC
COIPOOIDS; DIBLDIII; BLOOD SROB;
COLOliOO; DOST: BBHCBLOBOCiaOBBIH!
Occapatlonally exposed to DDT
CCT; DOS; ODD; PB3T1CIDBS; BIOOD;
ICIPOSB TISSDB; ClllOi; OCCOUTIOItL
IISaiDS; >OTOPSZES; BI01CCOBDLITI01
BffBBEKCI
Polishuk, Z.«.
Bon, n.
Vassersann, n.
Cocoa, s.
flaasersann, 0.
lessee h, C.
1977
Pearson, J. B.
Sennits. c.D.
Bivers, J.E.
Gonzalez, 7.H.
1976
Starr. B.G.. Jr.
lldrich, r.D.
BcDongall, I.D.
Bounce, L.B.
197a
Brovn, J.B.
Chov, L.T.
1975
CO
-------
Ithylane. l.l-dichloro-2.2-bla(p-cklocopbenyll- (B CII
Beaxene. 1.1«-tolcaloroalh«njlide»e|bU(»-ckloro- (9 CX)
12-55-9
CU-BB-CH
•I 318.02. 1C 88. « C
(COITIIOED)
TISSOB
2259
Brain
2260
Liver
2261
lllk
2262
Bilk
2263
Bilk
. I
HfOSOIB BOOTS
1IU.YTXCIL
RETROD
OC
OC
oc
GC
TLC
IDBBBB
OF CISES
ai
73
57
29
50
•1KB
a) lot given
b) lot given
a) lot given
b) lot given
0.01-1.72 ppa
tot given
0.9-113.2 ppb
("BIT
BXtl
a) 0.07 ppa
b) 0.66 ppa
a) 0.15 ppa
b) 2.22 ppa
0.22 ppa
0.0217 ppa
65.10 ppb
pur, I)
GEIEIIL XIPOIRaTXOI
at let tiaaae
b) Fat tiaaae
Data available for age and aex
qroapa.
lotopaiea fro* aabjecta < or • 82 yr
(tea Pori, Finland.
PISTXCXDBS; DDT; DDB; PO1TCHIOBIIITED
EXPRIIYLS; CBIOIIIB ORGilTC
COBPOOIDS; CB10RIIITBD RIDBOCIRBOIS;
ICXMSB IXSSOB; BBall; UTIB;
IOTOPSXBS; COHP1BIIIVB BT1LOHIOIS;
ICE; SBI; FXI11ID
a) let tiaaae
k) Fat tiaaaa
Data available for age and aex
qroapa.
latopaiea froa anbjecte < or - 82 yr.
fcea Porl and Jyvaakyla. Finland
PESTICIDES: DDT; DDB; POLTCHIOBIHTED
IIPIBlnS; CBLOIXIB OB6IIIC
COBPOOIDS; CBLO8XI1TBD RYDBOUBBOIS;
ICIPOSB TISSOB: BRtll; LIVES;
10TOPSIES; CCBPIBITITE SvlLOITIOIS;
ICE; SIX; FIILIID
lactatlng voaen in (elected areu of
Irkanaas and Bicaiaalppi.
BILK; PBSTICIDBS] ADIPOSE TXSSOB;
BITIBOLXTBS; CftLOBXIB OBGIIIC
CCRPOOIDS; CBLOBIIITED RTDBOCaBBOIS;
IICTITIOI; OXyCRtOBDIII; DDT;
ICIICBLOl; BEPTICRIOB BPOXIDt;
CIILDBXI; B1XICBLOFOCTCLOBEI1IB; DDE;
IBKIISIS; BXSSXSSXtPI
Blgher percentage! of organochlorine
inaecticldea and PCB'a in ailk of
aetkers 20-29 yeara tkan 30-39,
althoagk the foraer had lover levela
in plaaaa. Overweight woaen had
naigkt. Beaidoes concentrated in
extracted llpida of plasaa and ailk.
laraeli voaeo 2-* daya after noreal
dtlivery.
PESTICIDES: BLOOD PL is in ; unit;
POPOLITIOI IXPOSOBE; I3BIEL;
cnORIIlTBO BIDBOC1BB01S; LinDS;
ICt: DOT; DCD; DDE; POLXCBLOIIIITED
EIPREITLS; BcPTICBlOt RPOXIDI;
BIXkCBLOROCTCLORlXIIE
nl Ik aaaplea, hoapitala in urban
Oilo. I aaaflea froa Balllntdal, a
valley in aoothern lor«ay. lo
cccapational expoaare.
BILK; IISBCTICIDES; LICTITIO*;
CBLOIIIITED niDSOCJLBBOHS; CHIOHINB
01SIITC COBPOORDS; PESTICIDES; IOBRIT
BBFEIBICB
Battala. B.L.
Xkkala, J.
laoaakl, a.
Baatta, I.
arctila. 4.0.
1976
Battala. B.L.
tkkala, J.
taoaaki. B.
Raatta, R.
Irstila, I.D.
1976
.
KotX, F.I.
straaaaan, s.c.
Toba, I.B.
1976
Poliahnk. z.v.
Bon, R.
laaaeraann, B.
Cocoa, S.
Raaaaraann, D.
Leaeach. c .
1977
Bakken, l.r.
Seip, B.
1976
CO
-------
IthTlene, 1. 1-dlchloro-2,2-bll(p-cklocophMTll - (8 CI|
Beniena, 1,1«- (dlchloroethenjll.d*ne|lii«,(<-chloro- (9 CII
72-55-9
cii-a8-ci«
Bl 318.02. Rf 1)8.• C
(COHHORO)
TISSUE
2261
Bilk
2265
Bilk
2266
Bilk
2267
Bilk. Ttt
2268
Bilk. Cat
EIPOSOIB BOOT1
•
HU.TTICIL
BBTBOO
ec
CC
-
ec/Rs
ec
IDBBBI
OP CaSBS
36 of SI
at 23
b) 20
cl 12
dl «0
el 38
f) 19
g) 20
a) 19
t) 10
bt 25
cl 35
d) 10
e) 20
Slot
_ ven
a) 1*
b| 5
el 18
B»TOB
lot given
a) lot given
b) lot given
c) lot given
4) lot given
e) lot given
f) lot given
g) lot given
h) lot gives
a) lot given
b) lot given
c) lot given
d) lot given
e) tot given
f| 1-11* ag/g
lot given
a) lot given
b) lot given
c) lot given
BEtl
0.035 ppe
a) 2.8 ppe, fat basis
b) 2. 1 ppa. fat basis
c) 1.1 ppe, fat basis
41 3.3 ppa, fat basis
el 3.8 ppa, fat bails
f) 3.7 ppa, fat basis
g) 3. 9 ppa, fat bails
h) 1.0 ppa, fat basis
a) 29 ng/g
b) 3« ng/g
c) 3« ag/g
d) 21 ng/g
el 59 ng/g
ft 35 ng/g
«»97 eg/kg
a) 2.0 ag/kg
b| 1.7 ag/kg
c) 1.9 ag/kg
SEIEIIL II'OIBlTIOI
landoa subjects of greater St. Louis,
1C, aetcopollton area.
PESTICIDIS; CB10RIIE OB01IIC
COBPOOIDS; DCT; DDE; DIBLDIII;
RIUCRlOIOCTCLOBIIalE; RBPTtCBtOE
tFOUDB: Hill; BlSSOOal; COBHRaTIVE
lULnmOIS
•) 1970
b| 1971
c| 1972
4| 1973
e| 197*
f) 1975
g| 1976
b| 1977
latiaated fcoa graph
Rotkeri IB Osaka Prefecture
EIPRBITL COKOOIDS: CBLORIIE OBOillC
COBPOOIDS: DDE; DDT; DIBLDRII;
RKICBlOBOCKLOBIXall: J1F1E; BILK;
ECITCBLOIIIITID EIPIEITLS
i) Eastern Canada - -_
t| Quebec
cl Ontario
d| central Canada
e) lestern Canada
f) latlonal average, staples above 1
Bg/g
laitoaal Soever, 1975
EIPBBin COBPOOIDS: CallDa; CBLOBXIE
CIGIIIC COBPODIDS: DDE: DDT:
CIELDBIl: RIPT1CBLCI BPOXXDB;
BEIaCBLOBOBEHBII;
BIUCItOlOCIClORKtll: Bill;
ICHCHLOR; OXYCBlORDalB; PESTICIDES:
EOITCBLOBIIITID BIPBEinS;
POLTCBIOIXBMID TBIPBBtTLS
85 saaples-each is average frae 20
scthecs. Bilk obtained froa lactaria
ia Slovakia. 1971-1973. Taigas
at t let ted (roe, graph.
PISTICIDBS; aitK: PITS:
CZECBOSlOVaEIa:
BEXaCBLOBOCTCIOBEXlll: DDT; COB;
BmCBlOIOBIISBIE
a| Pooled staples. 1967
fc> Pooled saaples, 1968-1969
c) Pooled stsplea, 1971-1972
loaon IB Stockhola, Svedea
PISTXCIDBSt FOtOlaTXOB EXPOSDIB;
8IMt DDT: DOB; BXOaCCOaDlaTIOl;
SIBDBI
_
REFERENCE
JOBISOB, V.
Llv, G.J. K.
arabruter, J.
Kettolhnt, L.I.
Dracker, B.
1977
Takaihijl. T.
ittantbe, I.
Knuabara, K.
Toshlda, S.
Borl, S.
pakMhlaa. S.
Kashlioto, T.
foraaa. K.
lonita, I.
1979
Rei, 3.
Da vies, D.J.
1979
Sxokolav, 1.
Boilval. L.
Oknak, J.
Badarle, a.
1977
•estoo. G.
197*
U)
00
(IEXT P10II
-------
Itkjl
. 1,1-dlefcloio-2.2-bl»(D-CBloropha»»l|- (8 CT)
1,1«-(4ichloro«th«Bjlld«B«|bla(«-ckloro- (9 CI)
72-55-9
C1«-BB-C1«
Bl 318.02. BP 88.* C
(COnifOKD)
TISSUE
2269
811k. fit
2270
a ilk, fat
2271
111k.
«hol«
2272
811k,
•boll
ixtosmi BOOTB
- -
1ULRICI1
BBTBOD
OC-BC
OC-BC
OC-BC
OC
IDBBBI
or c*sis
... ...
al S3
b| 33
•I 3»
t» 6
22
al 1»
b) 5
c| 18
B1TCB
•) 0.173-8.12 ppi
b) 0.258-5.18 ppi
•) 2.16-73.83 ppi
b) 1.«7-2.«5 ppi
..
0.015-0.112 ppi
•) lot glvin
b) lot given
e) lot 9lv*a
BB*I
•1 2.23 ppi
b) 1.09 ppi
•I 1«.67 ppi
b) 1.920 ppi
0.061 ppi
•I 0.065 ag/kg
b) 0.052 «g/kg
c) 0.059 19/kJ
CBIIItL IIPOIIITIOI
. .
•I 1966-1970 stldr
b) 1977-1978 ctady
1966-70 p>tl*Bt« (0>lvu*ltJ of
llbcrti loaplMl). 2-10 <•}•
po«tp«ct«l. 1977-78 p«tUnt» (pabllc
h»ltk office* of llbtcti) , 17-309
diy« paitpirtn. K«14«nc««, BdKutoi
or llb«rt«.
Bill; PBSTICIDBS;
BIHCBL010CtCtOBH»IB; ODD; tOB; DDT:
CinDBIl; BSRTkCBlOl BWHDB;
BCI1CBMIOBBIHIB; CII1D1;
(OLTCB10BIIKID BXPIBBTtS:
COBPHITITB miOHIOIS
•I 81fk p«itlcld* a*«9« >c»
t| Low piitlcld* aw«* «r«*
IOMB living la st«kvlll«,
Bll«l««lppl (lo» pMtlcld* auq*) and
Dilti »c«« (klgk puttcld* ni«g«).
S»pl«i la 1973-1975.
BIIKI PBSTZCIDBS; DDB; ODD; COT;
BIUCBIOBOCTCMBntBB; BBPT1CBIOB
IEOIIDB; OXICBLOBDIIC; DIBLDUB;
BISSISSIPPI; CORPlllTttB BTIlOtTIOIS;
KtSOBBBBBT BBTBODS
S«t<*r, t«»t«rn kaitrallt, 1970-1971
22 nocmlng lotbiri. n «6-66 kg,
lUitig ulthlo « 30 it radia* of
Ptcta. B«it«ra taitnllm
IILK; PBSTICIDBS; lOSTItLIl; DDT;
CtB; DIBLOIII; RBXICBlOMBBItBIB
•) Pooled stiplaa, 1967
t| PooUd ••lpl»«, 1968-1969
c) PooUd •••pl««, 1971-1972
to««D la stockkoli, S«*d«n
PISTICtDSS: POPOltttOI EXPOSDBB;
BIH; DDT; DDB; BIUCCOBOLITIOI;
SIBDII
BBFBBBICB
cacrl*. 1.1.
Mdll. T.I.
Bc*ltkt«ltx, I.B.
Oiiiinghu, G. B.
Beam, 0. 1.
1979
BltHtt, I.I.
D'Bccol*. l.J.
Cila, J.O.
Icthar, l.D.
1979
Stac«T, C.I.
Thou*. B.<.
1975
(•3 tOO, G.
1971
VO
-------
Ferritlne
9007-73-2
cud coiposmoi OIRIOII OB
TISSUE
,
2273
Blood.
mra«
J27»
Blood.
eeran
EXPOSURE ROOtB
alaLTTICtL
RETROD
til
IOR8ER
Ot CtSES
•I 5
b) 5
15
81BG8
•I Dot given
b) lot glTen
a) 117-2270 ag/1
b) 1120-5200 oj/1
RE»»
a) 16 ng/dl
b) 2« 09/41
a) 515.6 og/1
b) 2«a9.8 og/1
GEIZBII. IirORHtTIOl
a) «oa«n taking a coiblnatloc ocal
contcac«ptl»«, aft«c 35 days on diet
b) as
etkaccin notrltlooallT adeqnt*.
Soa< «obj*cta: diatthea. son
throat, stoaatitls aphthoai.
ZIIC; COPPH; HETaLS; IITSOGII; BLOOD
StROR; Dial COITRICEPTITES; E10TEIIS;
•tllBOLISR
a| 10 pttlenti, «-18 yc old
t) 5 patient*, 23-«2 yc old
Data al»o (oc re binding and
afcaocptlon
fcogceialre re loading tilth
increasing age.
Pltienta «ltk fall clinical [ictoce
of B-thalaeaaeaia internedla. 5
pre»lo«alj tcanefaaed «itk 2-15 anits
blood, 5 pcetioesly tcanataied eitn
2!-«B enits.
BIHL3: TBaCE BLEHZRS; 1801; BLOOD
SZBOHi CCRFIBaTIVE BHI.OITIOIS; IGE:
CBILD1BI; tDOLTS: OBIIE;
ttoicamoiiiioi; rEcis: OIITID
KIIODOB
Beu, r.B.
King, J.c.
Rargen, S.
1977a
Pippard, B.J.
varnec, 6.T.
Callandec, S.T.
Weatherall, D.J.
1979
-------
Fiaoride
i6*8«-«8-a
F
Ml IB. 998*
TISSUE
227S
Blood
2276
Blood
2277
Blood.
•erae
2278
• ilk
2279
BLlk
IIPOSOBB M01B
InkaUtlOa
Ingeatlon
Infection
«
Inhalation
1I1LYTICIL
BITBOO
Uectrocken
Electrockee
BOBBBB
OF CaBBS
•1 «
b) 12
C) 3
d) S
•I »
f) 12
9) 12
h) S
1
1
1
B1BBB
•) 0.8-26.5 aB
b) 1.0-S.1 aB
c) 1.6-3.3 IB
d) 0.9-1.9 afl
•) 2. 3- MS aB
fj 1.7-3».0 aB
a) <0.3-96 aB
h) 0.1-1.8 aB
Bat applicable
.
1«-0 ng/i
2.1-15.5 ag/dl
a) 2.«-7.e an
b) 3B. 0-85.0 all
(•BIT
BBal
a) lot given
b) Bot given
c) Bot given
d) lot given
•) Dot given
f) lot given
g| Bot given
•) Bot given
1.6 ag/100 al
lot applicable
lot given
a) lot given
b) Rot given
PIGI)
GBBBBaL IBFOBBITIOB
a) latccaal lat«l« n«ac and to *7 hr
after d«liT«cr, Inorgaaic t
t) Coed !•*•!• n«ai and daring
d«llracy. Inorganic P
c) Infant 3-a day* old. inorganic ?
d| Batamal b«for* tr«ata«nt.
Inorganic F
a) Batanal 1«T*1« daring aad to «7
kr att«r dclinry, organic F
t) Cord !•*•!• dorlag dasllvarf.
organic F
g| Infant* 2-1* days old, organic P
k| Batornal !•?•!• bafor* trtatnwt.
organic F
B«t«bollt« !•*•!• of aathozjflaraa*
oiad as an analguic or an««tk«tlc
daring dall*«rr.
Iatl«nt< at 2 loch«*t«r, BT
hoipltala.
CIOOS; FLOORIIX COBPOOIDS;
BRaBOLITBSi BLOOD; BILK; IBIaBtS;
III TOIKt 1DOLTS
Igtop*;. Gaatrlc content* contained
26 ng F/100 al.
57-yr-old aaa foand d«ad attar
lagutlng an aakDom qaantlt] of rat
poloon.
FLOOSIDE; tOTOPSIES: BLOOD; OBIIB;
BMSOIKBBIT BBTBODS
Ckang* 6-72 br aft«r ingaatlcn of
an*p«clfl*d Mount of laandrj povdat
containing Ba2SF6.
2.S jc old girl.
Ctogr*o*l*« voaiting t latbargy.
coaatoo*. lupiratorr cat«, 6-8 par
Bin. Tiitchlng. coara* korliontal
nyatagaaa. ta>ponll<« 18 hr after
•diiasion.
s«t«r« kypocalcania. vmtricalar
arrartkilas, raapltatorr fallan.
FIOOBIDB) COBIBCTICOT; Ll»»01;
BILOGBIS: B100D SB BOB; OBIIB
loaan In Biraiagkai. Bristol,
Cardiff. Edlnbargk, and I»wc«Btl«.
SOOIOB; FLOOillE; IODIIE; BEHLS;
tILR; OIITBD IIIGDCH
•) Inorganic F
tj Organic F
l.i.la 21.S-««.S he aft«r
aathoxyflaran* ««» given as
an«tketic daring labor.
Patient at a Bocke*ter. IT hcapltal
CBDGS; FLOOBIIE COBPQDIDS;
BRtBOLITES; BLOOD; nlLK; IlItRTS;
IE« TOIK; 1COLTS
UFEBEICE
rrj, B.B.
Tavea, D.B.
197*
Speaker. J.B.
1976
Tolkea, R.
Konecnr, P.
BcCarthT. P.
1976
tnon
1977
Fry. ».«.
Tataa, 0. R.
197a
ts)
-------
TlDCCidO
1t?l»-«fl-
f
(CORT1IOZO)
trssir
2280
Teeth
2281
OclB*
2282
Ociae
2283
OciM
228*
OciM
tno.-'iti BOOTS
lageBtloa
Tngeatlon
Inhalation
k HI. IT1CH.
IETBOD
US
_.
Blacteochea
Blectcochea
Electrochaa
XSB
lOflBBI
or CISBS
35
1
1
•1 «
b) 1
Cl 30
41 28
•I 2»
b) 2*
BUCK
970-3120 ppi
- - ,- „
lot applicable
lot applicable
a) tot given
b) lot given
c) lot givea
d| lot givea
•I 0,230-2.729 ppa, caaoe
of aeana
b) 0.067-1.130 ppi, nag*
of Man*
nut
2160 ppa
_ .
32 a9/100 *1
2«. 8 19
a) 0.335 ag/1
b) 0. 137 ig/1
c) O.ass B9/1
d) 0.681 ag/1
al lot 9tr«B
b) lot 9lT«a
GME8U IIFOR!ltTIO»
C«ibrt«9«, nt schoclchlldnB
TI»CB ELIHEItS; IIZ1U.S; STBORI01;
HID; SOOI08; atGIESIOH: 1IIC;
FtOORIDE; HISStCBOiETTS: CRIIOBBI;
TIBTH; IIBiSOUlEIT 9ETHODS
>ntop*T. Oaatclc content* ccataiB*4
26 19 r/100 al.
!1-yc-oia *an total d«ad a(t«r
iagaitlag aa aakaoire qaaatlt; ot cat
(claoB.
FIOODIDE: HOIOPSIES; BLOOD; OBIIE;
IttSOIEHBIT lETgODS
12-hr aclBa «cc«tion
2.5 ye old 9lcl.
P[o9C»al»< Toaitlag t I«th«i9y,
caaatoa*. Basplcatocf cat*, 6*8 pat
•in. T>itchln9, ccacsa hocliOBtal
nf-taga«a. I«apoD«lT< 18 he attac
adaluloa.
S«1 yr of
•cck
4) 1 oc aoc« faa« farac aplacd-a, >1
Tt of «ork
6! >ock«c> ckoaan at candoa (coa
-------
fonaalda, I-aathyl-
123-39-7
C2-BS-I-0
ei 59.97. BP ieo-1as c
RSSDB
2285
irlna
2286
orlne
IIPOSDBB BOOTB
Inbalatlon
IBILTTICM.
BBTBOD
DC
ec
BOBBBB
or eats
8
100
BIBBB
a) 3.81-S.90 og/Bl
b) 665-873 ag
c) 0.23-0.36 ag/al
4) 5.8-26.9 ag
Bot given
8MB
. ...
a) «.7« og/nl
b) 736.8 ag
O 0.28 agSal
a) 11.6 ag
0.8 a 1/1
GIIBIII. IBPOBBITXOB
a) 7-br end-ef-oipoaaro dall]
concentration
t) 7-br end-oC-expomra dally total
c| 2«-br dally concentration
d) 2«-br dally total
S«b]ects eipoaad tc 8.79 ppa
dlnetbyieorianlde vapor for 6 br
dally.
8 bealthy aalea. 20-27 yr. 70-8* kg
and 173-183 en.
OBIIB; POP0UTIOI BtPOSOBB; HE
POllOTIOH; BniBOLITBS
loraal lavela
BMSOBBBBIt 8BTBODS; OBXIB
BBPBUBCB
(rlvanekt B.O.
BcUagblln. B.
Tayenaatber, I. B.
1978
Bacaea, J.B.
Baory. B.I.
197«
ro
j>
co
-------
qentaelcin
1*03-66-1
EHCT C01POSITIOI OIK10BI 08
IIP 102-108 C
TISSUE
2287
Blood,
Seree
2288
Blood.
seree
2211
Blood,
seras
2290
Hood.
serae
2291
Blood.
SVCae
2292
Blood,
serae
-
EXPOSURE BOOTS
Injection
Injection
Injection
Injection
Injection
Injection
-
IMLTTICtL
1BTHOD
,
BI»
Enxyeatlc
leeanodlffeslon
HDDBE8
or cisss
»l 5
bl S
c| 5
10
3
a) 16
b) 19
58
S
BUSS
•I lot given
b) lot given
c) lot given
a) lot given
b) lot 9lf«n
c) lot given
a) a. 5-7. 6 og/al
b) 2. 6-V.1 09/1!
c) 1.»-2.» ug/el
d| 0.2-0. S 09/1!
al 2.0-9.8 09/1!
b) 2.0-6.2 09/1!
2.8-8.0 ug/el
a) lot given
b) lot given
c) lot given
d) lot given
•) lot given
f) lot given
(I BIT
BE»I
a) 14.3 ug/el
b) o.J ag/el
c) S. 1 ag/el
a) S. 12 ag/el
b) *. 68 ug/«l
c) 0.26 ag/el
a) lot given
b) lot given
c) lot given
d| lot given
a) 3.77 » or - 0.8
og/el
b) 3.»9 » oc - 1.1
«g/»l
lot given
al 10.3 ng/el
b| 9.0 og/el
c) 3.5 og/el
d) 9.* og/el
e) 5.2 ag/el
f) 0.07 ag/el
P»0!)
GE1I8AL ZirOBBlTICI
a) Peak. 2.S ein
b) 10 eln
c) 60 eln
Kalthv subjects. Sapid intravenous
bolus injection.
CBOGS; BLOOD SEROB; kITIBIOTKS; «!»
JIlLklO
«)• 5 ein
b) 30 eln
c) 8 he
Iftec dose of 1 eg/kg.
Patients undergoing einor iaigery.
HOGS; ilTIBIOTICS; BLOOD SEtVB
a) 15 ela
t| 1 he
cl 2 be
d) 6 he
Iftec 80 eg dose (1.05-1. a eg/kg).
Raalthv eales (57-76 kg)
tlOGS; alTIBIOTICS; BLOOD SEFTJB
a) Day 1. Peaks after 37.5 ig/sg e
•very 6 hr
c| Day 1. Peaks after 1.25 tg/kg
•very 6 he
Peeks incceased 10* by day 6.
Chlldcen 26-210 eontns of age tilth
cancer, being treated foe inspected
gcas-nagetlve bacillacy infection.
IlTIBIOTICS: CBILDIEI; TEIIIESSE;
CtOGS; DBOG TBER1PT: BLOOD SHOO;
urecTioi
lange of peaks after 30-ein IT of 60
ag/sg s. Dosage, tased on body
tor face area rather than might.
resulted in tkecapautie peak
concentrations at all ages.
Oncology patients, ages 8 ao-73 yr
•tudied 1-* days after start of
treataent.
Cinieal toilcity: transient Incceaee
la seres cceatlnine
IlTIBIOTICS: BISSICHOSBTTS; CIOGS;
CIOG TBBR1PI; BLOOD SB BOB; IIFBCTIOI
a) Tiee 5 sin
b) Tine 10 sin
c) Tie* 60 sin
d) Tine 5 ein
e) Tin* 10 sin
f) Tine 60 eln
I (tec 80 eg dose (a-cl or 1 eg/kg
dose (d-f 1 .
etalthy adults (2 feeale, 3 sale)
aged 21-55 yr and et 5a-85 kg.
HOGS; HTIBIOTICS; BLOOD SI1UB
BEFEREICE
Bailey, R.R.
tynn, K.L.
197a
fan dee Belle, J.
Xdrlaensen, H.
I97a
George, f.H.
Bint, ».J.
Prangnell, D.R.
197»
Evans. v.E.
Feldean, s.
ossi, B.
Taylor. R.R.
Chaudhary. S.
Helton, E.T.
Barker, L.F.
1979
Siber. G.I.
Seith, ».L.
Levin, B.J.
1979
Stratford. B.C.
Dlison, s.
Coberoft. a.J.
197*
NJ
-------
GMttilcln
1*03-66-3
met COBVOSRXOB oinoti 01 OBOBIBBRIBBD
II 102-10* C
(CORIIOSD)
TxssoB
2293
Blood.
••CM
229*
Dell*
BIPO3VBB BOOtB
XajCCtlOB
In Action
IBaLRXCll
RBTBOO
Ucrobiologlcal
Blcrobiologlcal
IDBBEI
or CISBS
..
9
BIKE
•1 3.5»-7.20 us/Bl
b) 2.80-7.50 «9/Bl
a) 37-67 ag
b) «1-66 a?
•BIB
•1 5.«0 «9/«l
b) (.66 og/11
» S3 19
b) 5« 19
6BBBBI1 IirOBBHXOI
• ) Tkigh iBJKtlon
b) BlttOCk lB]*CttOB
P««k» (at 30 »ln) Bft» 80-»5 4a».
9 ial« and 1 (•>•!• roluat**cs.
C100S; HTIBIOTICS; BLOOD SBIUR;
DBIIB; OBITID KIBSOOH; COBPiHIITB
BflLOIIIOIS
a) Ihlgh InjKtion
b) Battock Injoction
6-kc •iccotloa aftoc 500-aq toio.
B »!• aqd 1 f«aal« *oloBt*«ta.
CB06S; 4ITI8IOTICS; BLOOD SBtOR;
Olllt; OBITCD HISDO8; COHPiHTITB
BVatOITIOfS
UrBBttlCB
B»«TM, D.S.
Br«at«c. B.J.
list, B.
ihtt.arak, T.8.
197a
Bo****. D.S.
By«at«r, 1. J.
HM. ».
Shitaarah, T.B.
197«
N)
-------
Gentasycln, salfata (salt) (6 CI)
Otntaalcin, salfate (salt) (9 CI)
aj-oe-s.T.-OBmo«i
IP 21U-237 C
TISSOB
2295
BlOOd,
sens
BTPOSDUB BOOTB
mimciL
BETHOD
Ucrobiological
«D»BI5
or CISBS
al »•»
b) n
BIKE
a) 1.«-*.7 ng/al
b) 1.8-0.5 ag/a:
HEtl
» »ot given
b) lot given
GEItBll IirOIMTIOl
a) Treataeot lasted 10.5 days
b) Treataent lasted 11 days Iverage
total dose 2 g. Patients in group (bl
had significantly higher sera and
credlcted tissee levels.
Bospltallied patients (average age
651 suffering severe infections,
usually complicating another
cendltioa (eajor surgery, chronic
cardloresplcatory disease, or
diabetes).
•11 patients in group (b) eihlblted
aaparotoiic effects.
UTIBIOTICS; BLOOD SBTOBj
BIOICCOROIITIOI: IIFKTIOI
ittnstce
Schentag, J.J.
Cnsbo, T.J.
Jnsko, «.J.
Plant, B.C.
1978
-------
Cmulti
7MO-56-*
at
Jktl 72.59, If 937.2 C, BP 2700 C. T? 10 H Bg tt 2080 C
nssiB
2296
LU9
•Honn nni
IBILTTICU.
••HOD
BS
IOHBB1
or c»s is
30
•MOB
lot A«t«cttbl«-1.9 «g/g
ACT «t
__
lot jl»«n
QBIBI1L IirOlllTIOl
3 «ha
kid bMD blM«lno*« cod Blair* foe
23-SO it.
iifus; THCI ILZBEITS: iioanoa:
enni; BBITIUOB: BOIOIJ CIIORXUI;
CCPP81; GligiHOB; XBOI; LUt;
BIQIESIOI; aiRtlBSE; nCKBli
sxticois SILVBI; TIB; Txtinm:
TIUDIOB; lOBOS! COH; OBITBC STUBS;
gOIRTI; BIBBIUS
IBTBBBBCB
CrabU. J.T.
KMDtD, B.8.
foloilcx. F.B.
(BOtt. 1.0.
Boltl, J.I.
SOClki, C.B.
1967
10
-------
Glucitol, 1,«:3,6-dlanhydro-, dlnltrata, D- (6 CI)
0-Glucltol, 1,a:3,6-dlanhydrc-, dlnltratt (9 CI)
81-33-2
C6-H8-I2-08
91 236.19, (IP 10 C
I TISSUE
229'
Blood.
plasaa
2298
Blood,
pla»a
EIPOSOBB ROUTE
In ga at Ion
Daraal
Tngaatlon
nitmcu.
BETBOO
.
oc
GC-BC
HOBB5R
or cis ss
<
2
BJIGE
«) lot gl*an
b) lot gltan
c) lot gl»n
1) lot gltan
•) lot given
f) lot glTan
g) lot gl*«n
_
a) lot qi»«n
b) lot git»a
e) lot gl»en
HE>I
«1 2.8 ng/il
bl 15.9 09/1!
c| 3.2 D9/»l
d) 1. « ng/tl
a) 3.5 ng/il
f) 6.2 ng/.l.
9) 1.0 ng/.l
a) 38 og/al
b) 26. S 119/1!
c) 5i.O ng/al
GIlIBtL IlrOBKtTIO*
a) S iln aftcc mbllngaal don
b) 30 iln aftcc aotllngaal dcse
c) 2 he attar aabllngaal dosa
d) 30 aln attar oiltMDt application
a) 2 he attar otntaant application
t) 6 hr attar olDtaant application
91 32 hr attar olntaant application
Eaalthy adult aalea, 19-26 yi.
•alghlng 62-88 kg.
OBOGS; lITItTES; BtOOD PlJkSHI; SKII;
CCBPlBtTITE ITlLOtTIOIS; IDUITS
a) Paak laoaorblda dlnltrata, 10 aln
attar 5-ag deaa
II Paak laoaorblde 2-aononltrata
(aatabollta) , 30 aln attar 5-ag doaa
c) Paak Isoaorblda S-aononltrata
(aatabollta). 30 aln attac 5-ag doaa
CHUGS; BLOOD PllSBI; HETtBOlITES: III
»HO IlltlSIS; II TITBO iHLlSIS;
OCCS; COBPIJITIVE tTUDltlOIS; IE«
1CBK
BEPZBEIICE
Hansal-Jonea, D.
Taylor, T.
Doyla, t.
Chasaaand. L. P.
Darragh, t.
O'Kelly, D.t.
Oter, B.
1978
Chin, D.I.
Prua. D.G.
Blchalocci, J.
Hho, B.T.
Warner. C.It.
1917
ts>
4?-
00
-------
Qlltaalc acid. l-(p-(|(2.«-41««i]io-«-pt*rialnrl)i«tkrl)MtkrU*iBO)bwiarl|-. t-<»|- (8 CD
L-Olataeic add. B-(»-C((2.4-dianlno-6-ptaria'tnvl)aetbjl|aeth7la»ino|ben»ojl|- (» CX)
59-05-2
C20-B22-I8-O5
II 454.46. IS 185 C (decoip)
TISSUE
2299
Blood.
•era*
2300
Blood,
•«cai
2301
Plenral
floli
EXPOSURE BOUTS
Injection
Injection
Inaction
immcil.
•RIOD
.
Bit
Competitive
protein binding
Competitive
protein binding
EOBBEB
OF CASES
12
1
1
UMB
•1 1x10{B-«)-3x10|B-8)
molmm/i
b) 2z10|B-«)-2.Sx10(f-7|
•Ol*M/l
e) 5z10(B-5|-2z10(B-T)
•alu/1
a) «20-0.006« gg/kl
b) 560-0.3 ag/»l
.
250-25 ag/il
BUB
» Bat glnn
b) lot g inn
e| (at given
i) lot applicable
b) lot applicable
lot applicable
QBBIUL IIFOBBITIOI
a| Betbotmate be 1-2*. plui
tbyaldln* kc 2*-72
t( Bctbotrazata kr 1-24, plui
Ion-do** l**cororio be 24-48
c| Mtkotraxat* be 1-2*, pla*
higb-dOM l«aco*oiiB > or • S» br
Bang* of nans, 1 and 12 he after
••tkotcaxate, 3.375 g/*g e.
Patient* with advanced cancer.
Ic netkotrexate toxicltT
DBOGSt DBOG TBBBlPTt BtOOO StlOB:
CBIBOTIBBIPI] COBPUktlVB
EfkLomoiSi oxsBisis:
lltlCOLOBBDOTRBUll STSTBB: OlITED
STATES
a) llthont clearal eff ulon
t| iltk pleural etfoilop
lange 0 and 86 br after two c-kr
Infulons of 400 ngAg. Contineo**
biexponentlal decline.
12-yr-old with netastatic
oateoiarcoaa.
DIOSS; CIIIOTIBBaPTi BBOPLISES;
CBILDlEBl tlllESSBE; BLOOD SHDB:
HEOBkl riOXD; OSTEOSlICOBtS
Bang* 12 and 48 br after two 6-hr
infulon of 400 ng/kg. Level about
10 tlee* higher than *eran level.
12-yr-old *ith nttatatlc
cateocarcona.
EBOGS; CBBIOTBEBm: IBOPllSaS;
CBILDBBB; TBBBBSSBB; BLOOD SIROB:
PIBDItL flOID; OSTEOStlCOBtS
1
UFZIEICB
Booell. S.B.
Kriahan, 1.
Frel, E., Ill
1979
Evans. 1. B.
Pratt. C.B.
1978
Evan*. I.E.
Pratt, C.B.
1978
N>
*»
VD
-------
CUtaciBid*. 2-«tBYl-2-ph«nyl- (8 "I
2.6-Plparidin«dlon«. 3-.thyl-3-ph.nyl-
77-21-*
C13-B1S-B-02
HI 217.26. BP dl foci 8» C
CI)
TISSOB
2302
Blood
2303
Blood
230*
Blood,
plena
EXPOSURE BODTt
Ingeotion
Ingectlon
• Ml men.
BBTHOD
.
GC
Biedec aathod
BOHBBB
OP C1SSS
1
13
63
BIIOB
al lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
2.0-1*0.0 ug/al
.
2.0-63.0 og/al
L
SB
al 1.6 ag
bl 1.2 ag
c) *.0 Bg
d) 1.8 19
31.0 ag/al
20.1 og/al
Ctlflll IirORBlTIOI
•I Slat.thliid*, • kc pr.-dl.lr«i«
b) Glat.thlild., 10 he po«t-dlalr«i»
e| lctl>. i.t.bollt*.
•-hTdcoiy-2-.thjl-2-ph.nflglot«rl«iil.
, I kc pr.-dUlyiLi
d) tctlf. i.tibollt.,
. 10 kc poit-dlalyiLi
Iltl.at.d (cci
Pttl.nt *diltt«d to hospital vltb
dcig oracdon in laihTlll. ,
Ceu, diaiolihlng c.aplcatory .{fort,
ntgllgibl. d**p t.ndon r.fl.MS and
c«tpon>* to pain.
ctoas; Dioa IBOSI; SSDITITES;
BTPIOTICS: B100D; IBItBOLXTB!;
1EIISSSEI
D.ath caOMd by drag coibinttions
l*eocd« of 1239 d.athi in U.S. and
Canada. IB all, diaz.pai oc it>
i.tabollt. *•[• pc.a.nt in tb*
ti»a«* and, in coat ca»«, ioc« tkaa
oaa dt«g >a> found. lg«a: lai than
i-9C«at«c tkan 65 ft. High (t«q»ncy
of >aicid«. Otk«c data available.
••laonacr and fl«c«cal cong.itlon
aoat coiaon poataoct.a Cindlog
OIOGS; 01og 1SOSB; CalaD*; OITTED
SI1TES; OtlB; SIDlTXVISi ITPKTICSi
CSKBOTIOPtC 0(065; BLOOD; 11TBI;
IIDIBTS; IICOBOLIC BETnlOtS;
IOIIISIC ISDXCTII
IMcaga qaantltr ingaat^ T.T 9.
••an ag« 3* yc, aga rang* 15-6* yr.
Bypot.naloB, raiplcatocy failac* oc
infection, inpaicMnt of t«i(*catar«
cagalatlon, co*a, CIS d«pc««alon.
COM, plaiaa !•>•!. colng«*tlon of
bacbitiatca d«t«ciin«d «T*clty of
ecu. C fatal CUM (5 had
colagMtioi) inclaoid 3 > 60 jt* old.
16B; BMOD PlaSIt; BIPIOTICS; DHJO
• lOSt! laSSlCBOSRIS! DIOBS
BBrEBEDCE
lie*, i.S.
nation, J.T.
Barblion, B.D.
1977
rinkl*, s.s.
BcCloak.y, K.L.
Goodian, 1.3.
1979
ro
Wi
o
ecmablatt, D.J.
lllaa. B.D.
Bacaatx, J.S.
lo*l, B.J.
Shadw, R.I.
1979
-------
•eld. pkmTl- (• C))
itlc tci*, •IphA-oxo- (9 CI)
•11-71-*
CB-M-03
n iso.it. if 66 c. m 1*7-151 c
TXHOB
2305
OtiM
inosm loati
latoUtlon
lagvitlai
D«riil
tlUTRCtl
OTBOD
FlVOEOMtty
IDHBSI
or CUBS
s
umi
•] 78.5-10* «9/«l
bt 112.5-162.5 ig/fel
c) 0-»0 ug/il
A) 0-71.5 *g/*l
mi
•I 96 «g/tl
b) 138.2 «9/»l
et 10.5 » oc - 9.8
>«/•!
4) 19.5 » or - 17.2
19/11
SIIIU1 IIF01BIII01
•I 0«r 1 of *trc«B« •xpoaac*. «
•citar*
t) s«coBi coiMntlT* a«r at stynB*
tifoutr*, * «ork««
c) D»y 1, * control *otk«»
d| D»y 2. * coatrol laclMri
8 «ock*r» ID poljr*«tu pl*1;
it HITS; occopmoiu BIIIIDS;
STTIIMSs ItllBOUItS; UK fdlOTIOl;
RltlTI HltllDS
nriuici
Chaknbwtt, S.I.
1979
ro
Ul
-------
Cold
ItR 196.«665, BP 106«.-I6 C. If 2~>00 C, TP 1 » 89 at 1B69 C, 10 » Hq at 2160 C
ITISSUE"
2306
Blood,
seta*
Hale
"EIPOSOSB BOOT!"
iiatmcu."
BETBOD
IOBBE1
or cases
BlIGt
applicable
applicable
2.695 pp«
BEil
_
a) 62 »9/dl
b) 20 aq/dl
2.0SO pp»
a)
b)
16
«cd
Epl
Ihc
501
tio
sea
Con
loa
of
HIT
HE
Clt
I XT
an
CCP
MO
a IT
111
GEIEIIL IIFOBBITIOI
a) B«foc* diacccapiol
b) »tt«r dlaiccapccl
d >an tc*at«< «ltb geld
•cdlaa tkloaalat*.
Epl»taii«, •cchyioats and p«t»chia«.
Ihcoibocrtopcnla
OOID; SETIIS; CHIBOTHESIPT; CBOGS;
HOOD SEIOB; CHIPC1HH
roa 2 Tlllagu of Uaika
Indiana In tht tiaionai Teccitoclas
of T«n>za«la.
BIIB; TEIIZDIU; HETtLS; TBaCE
i sooiOR; »tnation; sincoi;
CltoiIlE; P011SSIOB; SCalDIDt:
IXTlfXOB; VII4DIOR; CBBOHIOB: OOLB;
aiiGtiEse; IIOI; CCBaLT; IICKEL;
CCPPEB; IIICj liSBHC; SEIBIIOB;
H01XIE; BOBIDIOB; STBOITIOB; SILfEB;
alTIROIT; lODHE; CBSI08; BIFIOB;
lIBTBalDR: C1BIOB: S4B18IOB; BCK01T
BEFEBEICE
Stafford, B.T.
Ccoiby, ».H.
1978
reckons. U.K.
Tclandla, J.I.
DUn«». B.
1917
Ln
ro
-------
Cunldine, t(2.6-dichlorob«niTlid«B»)amlBOl- (8 CI)
IfdratlaecarboxllidtBld*, 3- «2.6-dlchloroph«yl) B«tbTl«B«)- (9 CI)
•051-62-7
C8-B8-C1J-H
•I 231.10
TISSOI
2308
Blood,
pluaa
2309
Orin«
BIPOS0IB IOOTB
Infection
lagactlon
iniRicai.
BBTBOD
tadionetrT
ac
TIC
Udiosetry
ac
TIC
BOB BBS
or CISBS
8
8
iiKB
•) lot glraa
b) lot gi»«n
c) 1.2-5.2 Bg/Bl
d) 2.5-3.1 Bg/Bl
•) 157 ag
b) 222 ag
c) 76. 7-79. 7f at das*
•Ml
•) 160 » or - 15 ag
drag •galTalaats/Bl
b) «1« » or - 85 ig
dc«g «qat»«l«nt«/il
c) 2.5 » oc - 1.8
ag/Bl
d) 2.9 » oc - 0.3
»9/«l
•) lot «ppllc«bl«
b) lot applicable
aillUL IBTOIRITIOI
a| Man p«ak, 3-4 hr aft«r 16-aj
doc«, calcilatod fro* total
cadloacti*ltf
b) B«an peak. 3-* be aftcc 3!-ig
dom, cal«lat«d ftoa total
ladloacttTltT
c| p«ak« attic 16 ig. as ancbangcd
drag. Peak tla«. 3.8 kc
d) teak* attic 32 ag, tm nncbanoad
drag. P«ak tin, 2.8 br
ltt«r 1«-c laball«d doma.
fatlnta, agu aa-72 yc, ulth
•iMntlal hrpact«Bilon, taitid bafoc*
and att«c doM.
lo>«c«d blood pc««ian, >ild
••datlon.
ONUS; DlOe IBIlaPT: CBLOBIII OlOilXC
COBPOOIDS; B10OD PlaSRIi
BTPBITSISIOB; DBIBB; FBCBSi HOOD
fiBSSOBB
a) Dnehaagcd drug IB 160-bc ccln««,
•tt«r 16-Bg do«« (cap«Bl«s)
tl Onckaagcd drag In 160-hc «rln««
•ft«r 32-Bg do««
e) UC IB caaalatlT* 160-bc «rl»».
t«tl«nt», agu »«-72 re, «ltk
••HBtlal hTpntmsloB, fast«d b*fo»
and aft«c doa*.
lOMnd blood prasann, Blld
••datlon.
DBMS; DIOQ TBEBiPt; CBLOIIlt OBCIHIC
ecgpooios; BIOOO pitsit;
ItPBBTBBSIOl; OIIII; PBCIS1 O.OOD
H8330BB
BiFBUICB
Bcachaa, B.I.
iBMtt, B.
Irclakopoaloi, 4.1.
Chiang. s.T.
Bad In*. I.I.
laUnc, B.I.
iBClU, 1.0.
Goldberg. 1.
1980
Reachai, B.B.
Bnaett, B.
KTriakopoolos, l.l.
Chiang, s.T.
Ba«lia«, B.I.
iBlkw, B.I.
laclns, B.C.
Qoldbacg, n.
I960
ro
-------
51*81-61-9
C10-R16-B6-S
II 252.3*, HP 1*1-1*3 C
-«"-(2-(( (5-.«thrl-1 H-
-«-rl|»«thyl) thio|«tbrl|-
TISSOB
2310
Blood
EXPOSURE BOOTS
logwtloa
1ULTTICIL
RETROD
BMC
IQBBB1
or cis is
18.7-2.60 ig/1
lot applicable
GEItBIL IBFOBrUTXOI
Chang* (coi 8-15 he after ingxtlon.
3! jt old ian adcittad to hotpltal In
tk« l«tharlana« att«r telllwiat*
cocdoM of cla«tllla« and oiatcpaa.
DaconacloDi, •hakloq la th«
•itctiltl** at adalaalon, couclons 6
kr aft«c forced diamli.
OIOSS; DIDO IBOSt; IETBZ81ilCS:
IIT16B; BLOOD; OIHBP18S:
isicaonopic noes
1EFB1EBCE
Tan Uftfconn. i.l.t.B.
1979
10
-------
. 1-bOBSyl-2,3-diBOtkrl- (6 CI)
59-73-2
C10-I15-I3
II 177. 2«. •( 195- 197 C
- (9 ci»
TISSUE
2311
Blood.
plBBBB
BIPOSOBB BOOTS
lB9*Btlon
BllLYTXCIt
BBTSOD
BOBBI1
OP CiSBS
12
11KI
a) 0.4-0.6 IB
b) 0.1-2.B aB
c) O.B-0.6 uB
BBM
Bl 0.5 IB
b) O.C5 al
el lot 9l*BB
OIIIIIL XBTOBBITXOI
a) Steady Mate, a 2 of tkBcapy with
BBBB dally aoaa 10.8 mg
b) 11 patients after 2-12 BO therapy
•Itk 79 soya
c| 6 patlBBtB dBdag day 2 attar a ad
of ckroBlc therapy, rBBOB of BBBBB
CorcBlatlon bctnan plaiaa Icral Bad
coaalatlta dally dea*.
SabjBcta kB«lBg ••mBtiBl
kypirtBB«loB for BMB duration of 7.7
it-
nut, pacBlatnt fatlgw
(partlcalarly «ltk anrcl«a| . soft
Btool*. and dUzlnuB «kan rapidly
••BUlBq oprlght putara.
DIODS; DBOO tBBBaPT] BtOOD PnSSOBB;
BTPBBTBISI01] BiOOD PttSBi;
puisnmit
nrnncB
Cordar, C.I.
1978
to
Ln
Ln
-------
naiacklorobantol (lo posting* in CRBBLIIE).
TISSDB
2312
Bilk
BXPOSORE BOOTS
ilURIClL
RETBOD
GC
tic
HOBBEB
or CISBS
*) SO
b| IS
cl «
BUOB
a) 1.7-60.5 ppb
b) lot gi»«n
c| lot qlun
HEtl
» 9.7 ppb
b) 1.7 ppb
c) 10.0 ppb
GEIUIL IIPOBIUTIOI
a) til «tipl«*
b) Colo«tcm
c) 4-16 «k «tt«r birth of initnt
Bilk •«ipl«i> hospitals in alban
Olio. % «aapl«« fcoi Ballinsdal, a
»all«y in aoath«cn Ior««y. lo
cccapatioaal •xpoiure.
IILK; IISCCTICIDIS; tlCTJTIOl;
CBtOIIItTBD BIDBOCHBOIS; CRIOIIIB
cioiitc coironos; PESTICIDES; IOBSIT
BE7EBEICE
Bakkan, t.r.
S«lp. B.
1976
ro
Ul
-------
Ilppiclc ici4 (8 CD
SljrclM. f-b«MOTl- (9 CI)
495-69-2
C9-B9-B-03
II 179.17. BI 187-188 C
"tfssn —
2313
DCiM
inoami BOOTS
iBURicii
1BTBOD
Htorowtry
BOBBBB
OF CUBS
•1 1C. b|
10
UBOB
•) lot gl*«
b) lot giTra
BBkB
•) 0.72 • or - 0.31
9/1
b) 2.3* » or - 0.39
9/1
8EIII1L IIPOBB1TIOI
a) lot •xpo««i
b| BxpoMfl to tolan*. *i«r«o» !•*•!
280 ppi, 2 Ik «t«djr
1ol«n« in lie ana ••t«bolit« In
•cine net liMtr
OilM lot comctcd foe 4«n«lty,
••thcnol tlic in >t«o«pli*c«.
BIIlBOLtSl; BRiBOtlTBS: ORIR; .
CCBMBITXTB BTlLQUtQIS; IIDOSfHU
ITBOSPHBRES; BB1S01BBBIT BBTBOOSi
ctiatiT
BBTBUBCB
•oimA*. 1.
Io4m, B.
Oryaeh, (.
(•ichuat, H.
1979
N>
-------
Bydantoln, 5.5-dlphenyl- (A CI)
2t*-Taldasolidinedlone. S.S-dtphenyl- (9 CI|
C15-B12-I2-O2
II 252.26, HP 295-298 C
TISSUE
231*
Blood.
plain
2315
Blood.
plasaa
2316
Blood.
plaaaa
EXPOSOIB BOOTH
Ingeatlon
lagastion
IIILRICIL
•BTIOD
GC
oc
IOIBBI
or CUBS
1
•1 and c)
6
b) and d)
1
10
MISB
*) lot applicable
b) lot appllcabl*
c) lot applicable
d) Rot applicable
a) ».8-39.2 uaol/1
b) lot applicable
c) 0.8-6.2 uol/1
d) lot applicable
1.2-20.8 ag/al
_
(HIT
nil
al 52 ug/al
b) 65 09/1!
cl 35 19/11
d) 3 ag/al
a) 17. aa aaol/1
b) 2.8 aaol/1
c) 2.87 aaol/1
d) 0. » aaol/1
9.9* og/al
P18E)
GEIII1L IRPORIUTIO*
a) a he after iageatlon
b) 12 he after iBgostiOB-peak
c) 6 day* after iagestion
d) 13 day* after iageatioB
1.500 ag doat in tablet fora.
Feaale. aged 6 yr, adaitted to
laaderbilt Children1 « Hospital.
Sjaptoaa noted daring analfai*:
•tapor »lth reaponae only to deep
pain, apontaaeoaa and repetitive
oEiathotonic poaturlng and
intereittent diaconjogate poaition of
«]ai. fenerallsed tonic apaaaa.
apaea. coaa, lethargy, irragolar
reaplratory [atterna, treaora, and
ayatagau. loraal nearologic
eiaalnatlon after t« daya.
Icate pheaytcia o**rdoae
BIDOS; BLOOD PLtSIt; CISB BISTOBIBS;
CIILDIBI: TEIISSSEI
a) Patieata nitk caronic renal
fallare, aeaaored aa total plaaaa
t) ratient >ith renal transplant.
aeaaared aa total [laaaa
c| Patienta aith chronic renal
failure, aeaaared aa free plaaaa
d| Patient alth renal transplant.
aeasnred as free plasaa
Coaea of 200-500 ag/day
leaal patients aged 20 to 58 yr. 6
had heaodialysis for 2 »fc to 55 so.
1 had chronic rejection 5 yr after
renal transplant.
DtOOS; IIITOOS STSTEB DISI1SIS: DIDO
TIBIift: BLOOD PlkHa; S1LITI; OUT ED
IIIODOB
Deaea varied froa 150- aOO ag/day.
EFllepay patients, 13-38 yr eld.
amcoiTOLstiTs; BLOOD : BLOOC PLISBI;
OIPBBinRTDkROIISi DIOO TBBI1PT;
ci»i; SPIIIL noit
BEFBBBICE
Wilson. J.T.
Raff, J.6.
Kllroy, »-».
1979
Reynolds, P.
Jones, I.P.
Slroyanis, P.I.
Salt a, s.E.
1976
Tajda, P.
(llllaas. P. H.
Davidson, S.
Pa leaner, B.».
Breckenridge, 1.
197«
N5
U<
00
-------
lydaatola. 5.5-dlpkanyl- (« a)
J.a-lBidBIoltdiBedioae. 5.5-dlpkeayl- J9 CI)
S7-81-9
C1S-B12-B2-02
II 252.26. BP 295-MB C
(CORimiD)
nssai
2317
Blood.
pla*ea
2118
Hood,
••CM
2319
Blood.
•*rai
— •
BllOSm BOOTB
IBjectloa
lageetloB
XBgoetloB
tinmen.
BETBOD
gc
oc
BOBBBt
Of CMBS
7
1
1
um
•1 Bat gives
b) Bet given
c) «.6-l.9 »g/Bi
d) 6.9-2.6 ag/el
•) lot applicable
bl lot applicable
•I >200 uol/1
b) 71 naol/1
c) 30 oaol/1
(BBIT
BBaB
•) 52 ag/al
b) 26 ag/kl
c) Bot gives
d) Bot given
a) 13.5 «g/al
b) a.s og/.l
•1 Bot applicable
b) Bot applicable
e) lot applicable
PtOB)
6BI1I11 XBFOBUTIOB
a) Botkor, a(t«c regi*ea of », 6
ag/kg/day. oral
b) Botkor. a(t*c reglaon of 3.0
•g/kg/dar. ocal
e) 3 cklldEOB. 0.5 asd 2* kc after 5
•g/kg IT. g/kg IT.
•lagl* 4o««
c) aad d) ••tiaatod fcoa gca|k. Data
anilabl* tec kalt-ll«« of nbjact*
aad UBC«lat«d dcag-fn* «pil«ptic«.
32 yc old epileptic eotbec, a
kypoaataboliiac, aad kec available
kinaklp.
Toilcltf at «.6 aad 3.0
oral. Syaptoiai aloi aoBtatloa,
pooc eeaocT, aild ataxla,
iBcoaeleteat Byetagaaa.
DIOOSl 0100 TBBBiPts OBBBTIC BVrBCTS;
BtOOD PLtSBk; DIIIBj PSTCBOTIOPIC
CIOOS; IBTICOIVOLSIITS: TBZISi
CCIPlltTITE ITltOaTIOBS
a) 2 BO aftec atact of 300
b) 1« BO latec, ao« taking (SO eg/day
tt eack doee level, conceatratioB IB
blood decceaaed »itk tiae. Optiaal
levele decreased fceqaency of attacka
feattac tkaa aaboptlaal levela.
Tilnaa eatlaated from graph. Bore
data available.
Patlenta at the aeacologlcal clinic
at Klag'e College Boepital.
(BTICOITOLStBTS; OIPBIlnBIDIBTOIlS;
BIOOO SB*DB: DBOOS: OIITBD KIBGDOB;
HBfOOS STSTIB OISHSIS
•I tftar aeveEal yi of 100 eg tvice a
day followed by aeveral *k of 3 or »
doaaa a day
k) level 7 days after ceaalng
trtataant
c) Level 2 ao after ceaaeiBg 100 ag
tiice a day
14 yc old epileptic.
Idalttod to kospltal eitk aatked
apaeticity aad ataxia. Otkei
ayaptoaa included dlplopia,
nyatagaaa. bypecflesia and clonos.
DIOOSs 0100 TREIIPI; BtOOO S1BOB;
1BOROLOOIC BllirBSTkTIOISi ICSTULI1
BBTBIBICI
Taako, B.I.
Bell, B.O.
Daly, D.D.
Pippeager, C.B.
1980
Beyaolda, B.B.
ckad>ick, D.
ealbraltk, i.».
1976
K>
Ui
VO
Stack, B.J.
1979
-------
Bydantoln. S.S-dlphonyl- (8 ci|
2.*-Islda»lldlnedloiM. 5,S-dlphenyl- (9 CD
57-»1-0
C15-H12-R2-02
Bl 2S2.2«. BP 295-298 C
(COHTIEOED)
TISSOS
2320
Blood.
sens
2321
Blood.
serai
2322
Blood.
serni
2323
Blood.
sens
-
232*
Brain
2325
Cerebrosp
Inal
field
EXPOSOBE BOOT*
Ingestlon
Injection
Ingestlon
Ingestlon
Ingest Ion
IIILTTICIL
BETROD
OC
RI1
OC
GC
OC
GC
BOBBER
or CISES
1
1
a
6
11
10
BIBGE
lot given
7.7-2.9 sg/1
1-18 ng/sl
a) 30-35 asoles/1
b) 28-29 asoles/1
1.0-16.2 ag/g
<0.5-3.9 og/el
HBII
<3 ag/il
lot given
lot given
a) Bot given
b) lot given
5.9 »g/g
1.33 ng/ll
GEIEBtL IIFOBIUTIOI
100 or 200 ng t.i. d. over extended
period. Level belcv the therapeutic
range of 10-20 ng/sl.
27-yr-old nosan with petit sal, focal
•etor selsares. and occasional grand
•al first seen at 33 vk gestation.
Infant delivered at 39 vk.
OIBSOB; DBOGS; DROG THEBIPI;
PllCEITl; FETOS; SILK; BBBBOil;
IirtlTS; IEOE080SCOIIB DISEIEES;
BIOOD; BIOOD SBBOB; IHICOIVOLSIITS;
ItCTtTIOl; OBBILICIL COBD
typical change. 0. 16 and 56 br after
3.6 ig/kg, ••tinted froi graph.
Blexponentlal decline froi 0.
Bealthy volunteer
IITICOITOLSHTS; BIOOD SEROB; IBB
ICK; SEX; TBIOCIlllTES; SBOKXIG;
CCBPIIITIVE EVUOITIOIS; DBOGS; DBOG
IBEilPT; PIOTEIIS; TOBICCOS; IDOLTS
predose values, 200-600 sg/day.
single or tslce dally doses.
3 healthy sales. 29-35 yr. and 1
sale, 38 yr, tilth grand aal aslsores.
DB06S; IBTICOIfOLSlITS; BLOOC SEBOB:
BIOtCCOBOllTIOI; BETtBOLISB: tDOLTS;
IEFVOOS STSTEB DISUSES
a) 2* hr range of seass. control day.
following 3 so reglsen of 1SO-«00
sg/day In 2 doses. 89. 0-91. «
proteln-boend
t) 2» hr range of seans, dose as In
a) plas BOO sg sodlas valproate after
first dose. 86.5-90.0* phenytoin
Jroteln-bonnd at sodles valproate
evels of 300 asoles/1.
21-39 yr olds vlth chronic erllepsy.
DB08S; DIDG THBBtPT; IfTICOIVOLSlITS;
ICOLTS: OIITID HIGDOB; BLOOC SEBDB;
DBOG IITBBtCTIOI: IBBVOOS SISTBB
CISBaSBS: DISEtSBS
Ccses varied froi ISO-BOO sg/day.
Epilepsy patients. 13-38 yr eld.
tlTICOIVOLSIITS; BLOOD: BLOOC PUS 81;
DIPBBITLBTDtROIIS; DROQ TBEUPI;
tllll; SPIIIL PLOID
Doses varied froi 150- «00 ig/day.
Belle psy patients. 13-38 yr eld.
IITICOBTOLSIKS: BLOOD; BLOOC PLISHa;
DIPHEITLBTD1ROIIS; DROG TBEUPI;
BIIII; SPIIIL PLDIC
BEFBBEICE
Dickinson, B.3.
Bar land, B.C.
Lynn, B.K.
Sslth, B.
Gerber, 1.
1979
Cose, J.Q.
Barron, S.I.
Josko, B.J.
1978
1 lien, J.P.
Lodden. T.n.
Purron, S.B.
Clesentl. ».l.
Stavchansky, S.I.
1979
Bonks, 1.
Rlchens, 1.
1980
vajda, r.
BlUlass, r.H.
Davidson, s.
ralconer, B.I.
Breckenrldge. 1.
1971
Tajda. T.
•illlais, p.l.
Davidson. S.
Falconer. I.I.
Breckenrldge, I.
197*
(BEIT PIGE)
-------
lydaatola. S.S-dlpbenyl- (B CX)
2,a-xliaaioiidina4ioM, s.s-diphaayi- (9 en
ST-»1-0
C«-i12-l2-02
II 2S2.2C. »t 295-298 C
(COITIIOBD)
TISSUE
2326
Saliva
2327
PEln*
1IMSOII BOOT!
Inject loi
alliniCal
BRBOD
OC
OC
IOBBBB
or CM is
- .. ..
•1 «
b) 1
C) IT
6
-— — — ~_ —
IIISB
a) 1.0-6.8 aw>l/l
b) lot applicable
c) 1.2-20.3 uol/1
•) 8.0-2B.61I at do**
b) 19.2-55.8* of doa*
an
•) 2.75 uol/1
b) 0.5 anol/1
c| lot 9l»«n
•) 15.21 of ao»»
b) 3». 17* of COM
einui iiroiiknoi
•) Pltltntl ilth ckconlc r«n«l
fallara
b) FitUat «ith nnl tr»n»pl»ot
c) IplUptlc p«ti«nt«
Iu«l pati«nt« rae«lnd 200-100
•9/day. Ipllcptlc ptticnts ne«irad
90-400 ig/diy. stlln »ipl«
•tlnlatcd by citric «eld.
l«a*l patlCBti aged 20 to SB yr. 6
hid kMOdlalyals tnttMnt fct 2 ok
to 55 loatk. 1 had chconlc rajvetlon
5 jc >ft«c r«B*l tEuwplant.
Ipllcptlc patient*. 8 (•»!•, 9 »!*,
3 to 55 yr old.
OIDGS; lllfODS STSTBB DX5B1SIS;
KIDIBTS! DIOG THMIPT; B100D PttSBk;
SIlITli OIITID KIIGDOI
•) 12 he
t) 2« ht
cmlatiT* •xcMtlODi of
p-hydroxrphanyl aotabollt* in 6
taiilr mbara, including th« lothcc.
32 yc old «pil«ptic loth*!, •
hypoMtabollnr. and k«c a Tall able
kinship.
loliclty at a. 6 and 3.0 ig/kg/4ay.
ocal. Syaptoaa: alo« aontatlon,
Foot aaaoty. alld ataila,
Iseonalltant nyatagana.
DIOBS: DIOG TBE11PI; 08IZTIC IFnCTS;
HOOD PltSHIi OBUt; PSTCIOTIOPIC
CIOGS; HTICOITDLSKT3; TEIiS;
CCHPlltTITC ZfalOlTIOIS
-
UTZIEICE
Beynolda. r.
Jonae, l.r.
licoyania, p.i.
Saith, S.B.
1976
Taako, B.I.
Ball. 1.0.
Daly, D.D.
Plppanaw, c.E.
1980
ON
I-1
-------
Ifdratroplc acid, a-banioyl- (9 ci)
g«ni««ac«tlc acid, 3-b«moTl-»lpka-««thf 1- (9 ci)
220"M-1S-»
C16-8H-03
HI 251.29. IE 9« C
TISSUE
2328
Or In*
EIPOSDBB BOOTE
immciL
•BTBOD
TOtc
lOHBSl
or cists
a| 1
b) 1
C) 1
It ICE
a) lot applicable
b) lot applicable
8E»1
a) 29.lt
b) 30.3*
<3EIIIIL IIFORMTIOI
a) Ketoprcten
t| Clucotonlde actabollt*
< of 300-ig/dar dom in 2«-ht aria*.
Bheaiatold acthritii patient.
DBOOS; DBOG TBEBlPT; OIITBD HIODOB:
aitSOIEHIIT BETHODS; OBIIE;
IITtMlITIS
BEFEIEICE
Thoias, 1.0.1.
Parfltt. i.t.
1979
ro
-------
ByOratroplc acia, p-laobotyl- (8 ci)
•••MBMmtlc acU. alBka-a«thyl-»-(2-Mtkylpropyl)- (9 CII
15*87-27-1
C13-I1B-02
II 206.27. If 75-77 C
txMoi
2329
Blood.
MTia
ICTOSOU 100TB
lag* atlo*
IIILITICIL
MTBOD
9C
IOBBEI
OF C1SBS
18
11NB
1-7 s «g/«l
Ull
lot gi»«n
SEIIUL IITOIB1TIOI
low and p»k nlM«, 0 ud 1 kc of »
kE stldy. Do**, «00 ig/V kr. Large
larlttioBi b«t«mn patuot*.
FiUtati, «fra ««-70 yr, uttk
Ek«»atold actkritla 3-22 jr.
BlOOSl B100 tHIlPT;
lITI-IBFLIBHtTOBT KBITS; tllLOBSICSi
tGOLTS; III (Mllll; BIOOD 3HOH!
COmUTXVt (TalOUIOIS
unnicE
Betcthu. l.l.
Perry, D.O.
Paliac. O.c.
1979
U)
-------
Bydratropic acid, 3-chloro-a-(3-pytrolln-1-rl) - (8 CD
etniaixacetlc acid, 3-cbloro-a-(2,5-4lhydro-1B-pyrrol-1-yl)-alpha-a«thyl-
31793-07-a
C13-BU-C1-1-02
II 251.13
CI|
TISSOB
2330
Blood.
plasaa
EXPOSORI BOOTS
Inflation
altlYTIClL
BBTHOD
IOBBEB
or casts
3
BUGS
.
a) 8-0. 1 ng/al
b) 5-0.08 ug/sl
*" * BE«S
a) lot applicable
b) lot applicable
GEHRIL IIPOiaiTIOl
teak (1.5-2 be) to 30 br after
administration
a) Single dose of 100 ag
t) Single dose of 50 •<)
loraal aales, 22-37 yr age
Drag is nonsteroidal, and dou not
h«»« endocrine effects.
Gastrointestinal ulceratlon possible
hazard vita blah dcaages.
IITI-I«FHBS»TO«t IOBHTS; 1IUGBSICS;
BLOOD; BLOOD PLtSHt; COBPIBHITB
IllLOlTIOIS; DBOG TREBtPT
1EFZB.ERCE
Proctor, J.D.
Ivans, E.F.
caspos. T.
velandla. J.
Pollack, D.
lingfield, V.L.
(assarsan, ».J-
197a
to
-------
Xiiduol«-1-«tktnol, •lphB-(chlocOMthyl)-2-mthrl-S-nitco- (8 CD
U-IiU»ol*-1-«th«nol. >lph»-|cklocM«thjl>-2-Mtlirl-5-aitro- (9 CI)
1«TT3-«2-S
C1-B10-C1-I3-03
H 219.65
nssoi
2331
OclM
BXVOSHIB 100TB
X>9«*tloi
II1LTTIC11
BBTBOD
IORBBS
OF CUBS
3
UNI
*3-63I
«B»
53»
.
aniUL inoBUTioi
1 of do«« «cnt«4 daring 2 tay*
•ftit 10 19 antteioU/kq. < «S
••a caa]«g>t«A Htabollt**
S ntiboUt** ll«ntltl«d. otkvr d»t«
tdalti
OIOQS; D108 THBIIPI; BBItBOltSR;
01IIB: BOOS; COBPktlTXfB BTtlOMIOBS;
anuia
Schmrti, D.B.
Jocflu, J.-C.
T«tt*c. I.
0««ttch«lt, G.
19T9
to
-------
ladlcln* (8 CI)
Batanolc acid. 2,3-dlhTdroii-2-(1-i«tkTl«tbrll-,
UO-B2-0
C1S-R25-I-05
HI 249.«1
(2,3,5.7a-t«tcahTdro-1-hrdr<»r-1B-prrrollzU-7-rL)a«thrl astir, (1 B~(1alpha.7(2g*.3S*),7ab«ta))- (9 Cl)
TISSUE
2332
Blood.
plassa
2333
Otiaa
BXPO50IB IOOTE
Injection
Injection
till, meal
RMBOD
OC-BC
OC-IC
_
IDBBBB
or ctsss
IftlGE
lot glxn
>0-120 ag
-
REtl
10 ug/al
lot given
....
GIlIBtl lIFOBBaTIOl
Paak T»laa at 1-» he after 3.0 g/aq a
Indlcine l-oside
PatUnts, 31-78 jt old, vith adrancsd
circlnoaa.
Snaralbl* l«kop*nla and/or
thcosbocytopania, •y*losnppr€ssion.
h*lopol«tic toilcitf, slid naasca.
toaltlBg. R1U h«patotoiiclty.
DBOGS; DIDG TBEB1PT; IKOPLaSBS;
IlItLOIDS; BLOOD PlISHt; OBI IB;
CREBOTREIaPT; CtBCIIOBtS
2*-hc ariiMS, 750-5700 19 indiclna
l-oiid« doses. Excntion ralatad to
dosa, c-O.BO (P<0.05). Estlaatsd
fcoa gcaph.
Patlants, 31-7R yr old, vith advaDcsd
cacclaosa.
BaTacalbl* laokop«nla and/or
tkroabocftopanla, araloaapprualon.
haiopolatlc toiicltr, slid aaaaaa.
*c lit log. Rlld hapatotoxicitr.
DIOGS; DIOO TREIaPT: IBOPLlStS;
tlllLOIDS; BLOOD PUSBl; DIXIE;
CBIBOTBBBIPT; CilCIIOHtS
BEFEBEBCE |
Kol«ch, J.S.
1M*> H.B.
Pools. G.
Botrtal, C.O.
Rahn, B.G.
Craagan, E.T.
1979
Kovach. J.S.
IMS, n.n.
Pools. G.
Boartal, C.O.
Bahn. I.G.
Craagan, E.T.
1979
ON
-------
Xldol«-3-ac«tic acU, 1-{p-cklorobaB»07U-5-BatkoiT-2-aatfc7l- (8 CI)
1l-Indola-3-acatic «cld, 1-(*-cklOEObaB*oyl)-S-aathoxr-2-aatkrl- |9 CI)
53-86-1
C19HH6-C1-I-0*
II 357.81, If diffannt fora* 155 C. 162 C
TISSUE
233*
Blood.
plaaa*
2335
Blood.
plaaia
2336
Blood,
pluat
2337
Blood,
plant
BItOMIB MDtl
XngaatlAB
•••ogutric
Injactloi
XBgaatioa
laetal
iiURXcii
BBTIOD
OC-IC
OC
OC-BC
EPIC
IOBBBB
OP C1SB5
17
9
1
11
UMB
•) lot gl»an
b) lot jiran
c) lot glTaa
d) lot gl*aa
0.027-0.310 ag/Bl
0.68-0.2M *g/ll
•1 40S-715 ng/al
b) 913-1013 Bg/al
(IBII
Bill
•1 590 ng/Bl
b) 190 Bg/nl
c) BOO ng/ll
d) 365 ng/al
0.07B ag/il
lot appllcabla
» lot ginn
b) lot gi**n
71GB)
smut xiroiuTioi
•I 3 kc. «ft«r 25 ig
b) B kr «ft«r 25 «g
c) 3 hr «ft*c 25 ig plu prob«a«eid
d) B kc «ft«c 25 ig pl«« prot»n«cid
ftlM* ••tlutcd fcoi gnpk. UT«!»
«tt«c 3 «k of tcMtunt vltk 25 mg
iodoMthicia OT«CT B kt. Pcob>o«ctd
|O.S g«) tele* daily. Icaa «o4«c
plaaaa conc«Btcatlon tl«» c«c*«
lacc«aa«d Ccoi 2,553 he ag/al to
1,181 kc ng/ll «ttk pcobaaceid.
Pkacaacokiaotlc aad oth«r data
atallabl*.
6 am. 11 DOMII nitk ckaautcld
•rthcltla, 29-61 re old.
BBOOS; DIDO THEI1PI; IBBOI1TCIO
IBIIIXTIS; B10OD PUSBt; OIXIB;
CCBUMIIfB ZTILOlttOIS; OII1BD
IIIODOB
F«aka *(t«c 2 oc 3 doaaa of 0. 10-0. 30
ag/kg boij «t. DOM* at 8 he
latccTal*.
fcaaataca infaata ulth aaan tLcth nt
of 1,*98 g aad aoaa gaatatiocal
pactod of 32.2 wk, Oalnc^it) of
IllinoU Boipltal.
D100S; B100D PL1SBI; DIOO TBIRkPT;
miss; lira BIS: xiixiois
0.5 aad 12 he aftoc 0.2 ag/kg IT of
th« aodlaa tctcakydcat*. Doellaa •••
bia«poa«atlal.
Icoaataca infant »ltk patont dactaa
actacioaaa.
01003; BBtSOIBBBIT IBTBODS; BLOOD
EUSBl; tlTI-IIFLlBBtTORT 4GUTS;
iiriiTS
a) laaga of aaaas 1-2.5 he aftac 0.1
ag/kg, 2-16 caaa* par aaan
b| lango of aaan* 1-2 he aftae 0.2
ag/kg» 20* ca«« pac aaaD
1 ob*ae*ation pac ca«a. lo affact of
coat*, no diCfacanca in aaan aaziaaa
foe caapondaea, noncaapondac*.
reataca Infanta oith patant anctaa
actacioaaa, poatconcaptioa aga 32.5 •
oc - 3.5 «k.
33 of 65 aithac coaplata or [actial
patant dacta* actaeioaaa clonr*.
DIOGS; DBOO THBllPt; IiriiTS; BLOOD
PUSIU; C1I>D>
BBFIIBICB
Babac, B.
lallidar, L.
Sibaon, 1.
Llttlac, t.
oraa. B.1>B.
1978
-
Bhat, B.
TldTaaagac, D.
Tadapalli, B.
Ikallar. c.
Tiakac. B.
laatcaitac, t.
Brana, I.
1979
Etna, a. i.
1980
llpact. B.S.
latina, H.J.
Boaland. D.I.
Gcant, B.J.I.
Oll.y, P.B.
Soldin, S.J.
snyac, P.B.
Cocaaoi, F.
Ron*, B.D.
1979
ON
-------
Indole-3-acetic acid, 1-(p-chlotobanzoyl)-5-ietboiy-2-iethyl- (8 CI)
1B-Tndole-3-icetic acid, 1-(a-chloeoben»oyl)-5-aethoiy-2-iethyl- (9 CI)
53-86-1
IB 357.81. DF different focia IS? c, 162 c
TISSUEBIPOSOBB 8OOTE
(COITIIOED)
2331
B1004,
•ecm
2339
Ocine
Ingeitlon
Ingeitloa
alaLTTICal
SETSOD
GC-BC
IOBBBB
OF CISBS
0.2-a. 5 ug/il
a) 2*0-2.570 ag/ttj
b) 270-«,9«0 ag/d«r
c) 6«0-1«,ISO a9/«*y
d) 1,200-12,320 ag/d*r
lot gl»«n
b) 1,812
cl 9,970 og/a«r
d) », 760 a«/d»y
G(II»L IlfOPBtTIOI
ton and peak talue), 0 and 1 he of •
ht stadr. DOM, 2S ig/a hr.
Batliatcd ft 01 graph. Lacg*
taclatlon* b«t«««n patients.
fatl«nt«, ag«> It- 70 it, nitb
ch«aaatold acthcltis 3-22 fc.
Indig««tion In 1 of 3 caa*>.
Tkacapcitic bmifiti foe locoing
atiffn***, grip itrvngth, «a Iking
joint paraaitcc*.
CI08S; DB08 THBBaPT;
IBTT-IBriUHllOBT aSBBTS; 1BUGESICS;
« DOLTS; IE! ZEaLaBD; BLOOD StEOB:
COBPIB1TIIB ETaLOaTIOfS
a) Fc«« foci, aft«r 3 vk tccatwnt
b) Fr«« foci, aft*c 3 «k toot Mat
nlu prob«n«cid
e| n» foci, plus glacaronld*
conjigati, aftic 3 ik tccatiant
d) rcaw foci, plai glacaconid*
conjagat*, aftaic 3 «k tccatimt plo»
PatUat* c«c«l*«d 25 ig «»«ri 8 he
trob»«cld (O.S ga) twice daily.
Phaciacokin«tic data available.
6 Mn, 11 HOMO «i«h cheaiatold
acthcitii. 29-60 yc old.
DB09S; DBOG TBEB1PI; BHBOB1TCID
II1BBITIS; BLOOD PllSBa; OBIBB;
COBPlllTIfE BT4LOaTtOIS: OIITED
IIIGDOB
SEFEBEICE
BcAethae, t.
Fcccy, D.G.
PalMC, D.G.
1979
Babec, I.
Balllday. L.
Sibeon. B.
Llttlec, T.
Oca*, n.L'E.
1978
oo
-------
lodid*
20461-M-S
X
Itf 127.*
•nnn '
23*0
lllk
-BpoMiB BOWI
IIURICU,
BBIBOD
-
BVBBBB
OP CtSBS
HMB
2-12 ag/U
nil
lot glran
ClllUt IIPOlltTIOl
Iran In BlriinghM, Bristol,
CicdlfC, Bdlabargh, •>< Icucutl*.
soDing; riaami; IODIIB; RB»LS;
anii OIITED KXNDOH
UFBinn
Inao
19TT
N>
VO
-------
iodine
1553-56-2
1
It! 126.40*5. HP 113.60 C. BE IBS.2* C. VP (solid) 0.03 aa Bg at 0 c, 0.305 aa Bg at 25 C, 2.15* aa Rg at 50 C, 26.18 aa Bg a't 90 C
TISSOI
23*1
Blood,
plasaa
23*2
Blood,
••CO!
23*3
Hair
23»«
Orine
EIPOSOIE »OOTB
Oeraal
iiaLrricii
BETBOD
as
it
IS
IOBBSI
or ctsis
•1 16
b) 16
C) 12
4) 6
•) 6
•I 1
b) 1
11
•1 1
b) 1
BUGS
. -
«) lot gifen
b) lot given
c) lot 9ltr«
1) lot gU«n
•) lot given
a) lot applicable
b) lot applicable
11. 2-15. a ppa
a) lot applicable
b) *»-65 eg/41
(IBM
REII
a) »B og/100 al
b) 1* 09/100 al
c) ifl.O 09/100 al
4) 26.2 09/100 al
•I 15.9 09/100 al
a) «8.000 og/dl
b) 17.500 og/dl
13.* ppa
a) SO ag/41
b| 50.8 eg/41
PICK)
GEIIItL IirOIBlTXO*
a) Peak. 12 he after 1 application
b| 12 kc after 1 application
c| Oaf 3. Kith 3 application* a day
4) Day 3, single application
a) Day 3. control*
In a) and b) 5-6 of 16 infants as«d
foe aach aaclal 4at«cilnatlocp aa4
talaaa aca taken froa graph. In all.
application !• of (o>14on« led 1m to
oibllical cord and skin aroond it.
Iddltlonal data arallabla.
loraal t«ra naonatta born at cook
CoontT Hoapltal.
ICDIIB; TSICE BLEBERS; BLOOD PUSB1;
OIIIS; IIF1ITS; IHIIOIS
a) Patlant 1. post-born day 11
b) Patlmt 2, post-born day W
30 yr old patient «ith 15% born, and
12 yr 014 patient ulth 35* born.
tcldosis, renal inaaff Iclency.
cacdloresplratory arrest,
cradycardia. hypotension. Death froa
paeodononas bronchopneononla .
Tacoolar degeneration o( proiiaal
convoluted toboles. Polaonary edeaa.
IODIII; DB003; BLOOD SEtOH; OB I IB
Scalp hair
Conors fron 2 villages of lalka
Indians in the laaionas Territories
of Teneioela.
B«I«; fllBIOBU; BEIILS; TltCE
I1IREIM; SODIOBi ILOUIOI; 3ILICOI;
CBLOUIE; POMSSIOBl SCtlDITri;
imilOBj tlUDIOH; CBIOBIOB; GOLD;
IIIOillSE; IlOli COBtLT; IICBL)
COPPBl; SIIC: IBSBIIC; SILEIIDB;
BIOnilB: BOBIDIOB: STIORIOB; SILTSB;
• ITI90BT: lOtlll; CESIHB; B1BIOBJ
IIIIBIBOS: CEIXDB; SHIBIOB; BEICOBT
a) Patieat 1, post-born day 11
b) Patient 2. post-born day 10
30 yr old patient elth 15* born, and
12 yr old patient alth 35% born.
Icidosls, renal insofficiency,
cacdloresplratory arrest,
bradycardla, kypotenslon. Death froa
[aandoaonas bronchopneoaonla .
tacoolar degeneration of proxiaal
connoloted taboles. Polaary edeaa.
IODIII! DOTaSl BLOOD SBlOHl OIIIB
IBFEaEICE
pyati, s.p.
Paaaaarthy, l.s.
Kraass, B.T.
Pildes, R.s.
1977
Pietsch, J.
Beaklns, J.L.
1976
Perkons, l.K.
Telandia, J.I.
Dienes, B.
1977
Pietsch, J.
Beakins, J.L.
1976
ro
^j
o
-------
lOdlM
TSS3-S6-2
I
Itt 126.*0*S. W 113.CO C. Bt 185.2* C. W (will) 0.03 » Bg at 0 C. 0.305 aa Bg at 25 C. 2.1S* •• 19 at 50 C. 26. 78 •• Rg at 90 C
(CORIIOBD)
TISSOB
23«S
Urlna
23*6
Urina
BlfOSHBB BORB
Daraal
lutmctL
BBTBOD
_
»
BOBBBB
or CISBS
3
a| 1
b| 1
11IGI
I) lot gi»an
b) lot gl*«n
•| 96-612 og/2« hr
b) 255-921 99/2* kc
nil
*| 2989 ag/1
b) 986.6 ag/1
a) 210 ag/2« he
b) 588 ag/2* he
8IIII1L IITOIUTXOI
- _.
•) Day 1 aft«c alngl* applicatloo of
po*ldoa« lollpa to labilical cord «nd
akin acoaad it
E| Day 2 attar alngla application
Iddltlonal data avallabl*.
locaal tara a«oaataa bora at cook
County Boapltal.
IODIIB; IIIC1 ILBBBITS; BtOOt PLlSBt;
OIIBB; XBrtRSl ILLIWOIS
a) Baalthy aal«, 5 dataralaatlou
e*ar • ao
b) Baalthy (aaala. 2 dataralnationa
10 ao apart
Iddltlonal data avaUabla.
BBTU.S: TIICB BIIBBITS; IBSBHC;
BioniBt CILCIUB; CBioaiiB: COBILT;
CBBOBXOB; CBSXUB; COPPBIi BBK01T;
IQCXBBl POT1SSXOB; BliOHBSBj SODIOBj
IOBIDIDBI SBUBXOBi II 1C; OBXBB;
BBISOBBBBBT BBTBODS
..nine.
Pyati. S.P.
BaaaaarthTi I. s.
Kraaaa, g.t.
PiUaa. l.s.
1977
Conalla. a.
Spaacka, 1.
lost*, 3.
1975
to
-------
F«
ttl SS.M1
isis c tp*r*i.
c (c«ti. ISM c i*ra««kt). nee c
wi c, TP i «• §7 at i'«> c. to •• a« «t 20*0 c
TTSSI*
2M->
IdipOM
23««
aorta
23««
Blood
235*
•loot
23S1
Uoo*
sipostn torn
IU1THC11.
mot
1-raT mpoctroB
I-rmy •poctroa
US
n
IBBBSS
OF C1SB
•
•
Tj
a| 1*2
kl «43
BaBCI
Bot 9lToa
Bo* 9l*om
h) Bot 9l*oa
cl lot 9lv*m
*) Bot 9l*om
B) pot 9lTCjm
f} VBt 9lWOB
a) Bot 91***
M Bot 9l*om
BtiB
11. • ppa dry «t
1}J >p> teT M
b) 45 m9StM al
c) S3 ao/lt* al
d) 13% mo/IBB ml
•) 13% ma/IBB Bl
f) 129 B9/10B ml
a| 23M • or - 3M
09/9
kl 2TS3 » »r - 393
B9/9
niuu imsanioi
: «uplo> p»r ca«m. 2 amalyias par
•omplo.
m* aitopaiw of 18 Plaa laoiaa. a
Papa^o. aad a Cromk laUaa.
POTaSSni; CalCIBI: I1OI; COPPEt:
ttBC; BVBIBIBB; IICID.: Lilt: HTUS:
TUCI sunns: ii»n: spun; aont:
IIBBTTS; IBIPQSS TlSStl; HtCtllS;
2 *aapl*« p«t camm. 2 ualyam* om
•ack sampl*.
ir» aatopsiva of 10 Plma laflau, a
Papavo, mm* a Cromk XmUmm.
POTaSSm: CUCItl; noB: COtPtB:
xiBC: limit nB; ncra.; IJUB: amis;
TUCI Kunns; UTBB sriBB; aoni:
tlBBCTS: aBIPOSI TISSBI; PUOUS:
siksnnrar nrmots: impstE
a) Blood fcoa 22 actkvts. loa klrta
•t aroap (1SOB-2SOB 93
H Blood from SB motkmrm. motmml
blrtk «t sromp |>2S*t 91
e) Bloat from 22 motkmrs. Bormml
klrta at 9rcmp matcmo* altk torn blrtk
•t mroap foe mmx. Bmtormml mma. rmoo.
*aoklB9 kmbltm. earlty
4| cor* alcod from 22 motkrm-. lo>
klrtk mt 9romp
m| oar* Moo* from SB motkors. mormal
tlrtk vt 9romp Bmtcko* mltk Jov klrtk
wt mromp for mas. mmtarmml aga. ran.
BBoklaf kmelts. trndty.
Botkmrm Bko 90*0 blrtk 1m Baamrk. M.
lprll-»rtombmr. 19TS.
BIT4LS; CilCTBS; CBBUBIB8; CtrPB;
item-. ucnsiBB: UK: BIOOB; unrs;
Fms; BIB Jamsn; cainunBi
I1U»TIOBS
BnloB
•RUS: COftBBj IBOB; UCIXSKB;
•UGinsB; UK; nnuonoTtxis:
m) Babarmml
tl Potml
Irj >t kmmla
Smmplmm from • kompltalm 1m
BmmkTlU*. Tl.
pitctna: IITILS: TUCI i LIBERS:
TiBBisnt: nooB: Bin; COBIUTX*I
OaLBinOBS; BSICBn; 1AB; QBOIBB:
StURBIS IIBCTIBB; IBM; UK:
COBUT
UTOCTCT
•mamolmom. B.r.
•ill, B.B!
llalmoa. I.I.
Eatoafa. B.J.
CkrlmCommom. J.J.
Isatt. I.I.
Vlckmrds. B.O.
19T«
B..9*l»om. , .
•111. B.l!
lialaoB. 11. 1.
Eatooaa. B.J.
Ckrlatomamm. J.J.
Intt, l.l.
ttekarms. B.O.
I9T9
B0900B. 3.9.
temp. T.«.
Catorlal. I.
19^8
Sormmaom. J.I.J.
••91m.. ».J.
Brml. a.B.
Sckalmrt. i.
• 11 BIB B.
Larmam. I.
Br«:. B.
Sckaffmox.'l.
•ofrmaa. I.
BrnTlom* J«
19^M
ro
I HIT USD
-------
It* 5S.M7,
1S35 C
IWt-IWO C teutl. ISM C (BTOBBBt). U*0 C IttMll. m MM C.
1 BB l« «t
c. It BB 19 Bt 24M C
mam
2352
•loot
23S3
•loot.
BlBSBB
•load.
TajBctioB
XBfOStlCM
1BUTTICU
UMDB
us
mm
or CASBS
122
»-27 BOE
3 of 3*
MM*
Bt lot flVOB
M mot «ITOB
C) BOt fl*0*
Bl ISS-f *•/•!
•I I««-TS vf/tl
cl 1SS-C» a«yill
«) 1M-73 of/*!
> or • 7» *9/ai
BUI
U tt.3 • or - 32.1
BfSIM Bl
b) *7.S » or - 23.C
cl 1«».t » or - 31.1
Bl cot gins
b| lot f ln>
d) lot flram
•Ot fl**B
4IUUL 1UW-U1UI
B| stonoo ktttorj »u».tBt» »•;
•nDGiaiis; B*xn: uns; *BUXB c
Bl roatBBtel trootMBt
C| trOBBtal tTOBtBBBt
M«*l« IB iBfBBfe* «t blrtk-Blghor
•BlBBX. IBBVB is FBBOB Of BBBBm.
ffOBltBl IV iBJOCtiOB, iBfBBtm IB
froB 2-1* BO of B«t. Otter o»t«
IctkoES OOBB BOB of 27 jr. B«CO
SteCt. B«d VOX? littl» OdOCBtlOB BBd
liWd iB Boat BBBltBTT COBdttlOBB IB
IBBBOBtlB. (OXtcO. It pBTtBB.
fCT BB* BCBC tBBB BBtTOBtOd. 9*
l«*Bl« SBBO for kotk OTOO.B*.
BVBBOCU. GTOBBB M BBd C| ktofcOC 4t
•-12 BO iB BBlOB OBlf.
•mts; noi: suno pusai; nnns:
•mOM; nBGBftBCTT* XV VIVO XfAUSIS;
inico
CktUroB <• BB/dl. 3t Of C» BBBOjlObiBB <11
FltiOBtS Bt IU.VBBBOB C^lldnB'B
•capital
iu»: noi: moacixvs; notms:
ItTBLS; KOOB; B1OO SBB1I; Hal
vexsomc; cnuni: nscoisa
(•BBlOBUOB. 1.
Sokloc. t.
MolfCor. c.:.
lorlB. i.
SBBCkOZ-BOdBl. L.
trrofo, ?.
Mains, a!
CasBjnora. t.
SBOXd. KB,
N>
-------
Iron
7« 200 ppb
g| lockeca, aecondary Pb aaeltec »ith
blood Pb 101-200 ppb
h| lockeca, aecondary Pb aaelter «lth
blood Pb (01-500 ppb
1) loekera, aecondary Pb aaeltec «lth
blood Pb 701-800 ppb
BIT iLS i CIDBIOB; CCPPBI; IBOI; LB10;
BlldllESE; ZIIC; BIOOD: BLOOC SSSOB;
SBOKIIO; Dili COITUCSPTIVES;
IIDOSTIIBS; SHELTIB3; IDOIT5:
CIXLDBMl SIS; BBTBBUalDS
Idaiaaloa to «8 he after adsissioB
2* yr old black eoaan adsitted to
Bonteflore Boapltal, in Plttabacgk.
follovlng ingestlon of 10-15 fercoaa
aoltate tablets (3.0-a.s g|.
laoaea. voeitiag, genecallxed
•eakness, kypoactlve bonel acaada.
rloody atool
Blld tachycardia. Inverted T vavea in
precordlal leada (KB)
BHM.S; XBOBj BIOOD SBBOBi 01X11;
IBOtTS: CJSB BISTOIXBS; BOXCIOB:
FHISTLVtlll
a| Ben
b) BOBBB
Criteria for lev levels < 39 ag/100
al.
local otahna, 58 eea, 129 noaan, aean
age 69 yr.
OIITS! TB1CB BLEBEBtS; CBOLBSTBIO1S J
BIOOO SBIOB; IXKl COPPM; fOTkSSiail
SCDXOli BMBBSXOBi C11CIOB; HOIJ
VITtBXB 1| VITkBIBS
Black IOBBB aged »6 yr froa Jersey
City. IJ
Pile* rate of IOC/sin, grade XZ/TX
•idsystolic ejection aaraar, grand
•al sell are
taeaia. encepaalopathy, lead
nepbropathy, vitillgo and
hyperptgaeatatioB of gaas, pale
conjectlvae, eteres ealarged eith
Clbroayoaaa.
HID! IBOIj BBTHSJ BLOOD; BIOOD
SIBOBl HID POZSOIXBO) UBBXli HI
JIISIT; IZOtOLOQIC UBZnSTIIXOIS;
BIBTOOS SI51IB DISIkSBSi OBIIB
IBFEIBICB
ZielhalB, l.L.
del Caetilho, P.
Berber, l.r.H.
libovo, l.l.B.
1978
lallack. I.K.
Blnkelstein, I.
197*
riakec, S.
Rendricks. D.G.
Bakoney. *.l.
1978
(edeen, B.p.
aallik, O.K.
Bataaaa. T.
Bogdea, J.D.
-------
1MB
7«3*-M-C
1*1 SS.SB7, n 1515 C (para). 1000-1300 C (cut}. 1500 C (wrought), 1300 C (ataal). « 3000 C, ?» 1 mm Bg at 1707 C, 10 •• 19 «t 20*0 C
(com lot D|
TXSSOI
2359
BlOOd.
Mm
23CO
Blood.
aaraa
2361
Blood.
aaroa
Bitosm IOOTI
XBgaatloa
IigaatiOB
IngaatiOO
IM1RXC1L
IIHOD
•OIBBI
OF MSB
1
1
1
•1MB
lot gl*m
a) tot glTan
b) tot gl»a«
c) lot gi»an
•) lot applicable
b| lot applicable
e) lot applleablo
(IIR
BUI
HO 09/100 Bl
a) 3,630 09/41
b) 13,585 09/dl
c) 2*0 09/dl
a) 3. 1 og/Bl
b) 3.1 09/al
o) 0.9 09/Bl
PiOB)
6BBBUL IITOIRITIOI
Fatlent agad 2* living IB BrltaU had
porckaaad aphrodlalaca froa
taagladeab.
CoBatipatioa, pcooordlBl pala.
9aBacall«*d pals, colicky lota palo,
BBBMB, and tOBltlBJ
XBtostlBBl ilooa aldacoblactic aiwala
HID; git us; IBID roisoine; OIZTBD
IIlaDOB; BLOOD; UBIIB: B100D SBIOB
a) 8 kc attar logaatlOD
b| 11 kr attar iBgastloa
c) 2* he attar lagoBtloa
3.200-3.900 ag alaaaotal Iron
lagaatad.
ll-BOBtk-old boy koipltallcod aftar
iagoBtlBg 50-60 tarrooa aoltata
tablet*.
Sjiptoaa darlBg analravai ottandant
hfpotaaaioa, bloody diarrhaa,
aalctarlc, llvoc flra aad •Blacgad.
alavatad blood aaaonla. aodarata
acidoala and jBBBdlc*. Patlaat dlad
fellovlag cardiac irraat.
Baaalva hapatlc aaeroala.
inalSi IBOI| BBTaL POISOIIICj BLOOD
CltSBI; tITIBi KIDIBTSl BTPOHBSIOI;
CBILDIIIl CI3B BXSTOtlBS
a) « hr aftor 1631. B ag r*S04
b) IB he attar 1631.8 Bg PaSO*.
(koBphata iBTag*. Dararoxaaina XT.
calclaa glaeaptat*
c) 5* hr, with coatiaaad thacapy.
IS kg. 2 yr eld
Coaatoaa, latkarglc daring tbarapy,
bloody diarrhaa and voBltiag.
lypocalecBia, hyparphoaphataala,
bypoaagnaaaala hyparaatroBla,
aatabolle acldoaia.
CtLirOlltl; BBTtLS; BBTU POISOBIIO;
CBILDSBIJ BLOOD SBBOBl DIOO n>BaPT|
tlTUI
BxraiHo
Braarlay, I.L.
Foray tha, I.B.
1978
Olaaaoa, 1.1.
dalallo, D.B.
daCaatro, T.I.
Coenora, J.J.
1979
Backraeh, L.
Corraa, 1.
La»in. B.
Groaaaan, a.
1979
ro
»j
01
-------
Iron
1*34-89-6
Ft
itl 55.8*7, IP 1535 C (pan). 1000-1300 C (cut). 1500 C (nought), 1300 C (steal), BP 3000 C, It 1 « Hg at 178? C. 10 •• 89 at 20*0 c
(COITIIOED)
nssoi
2362
Blood.
•area
2363
Blood,
•erne
236*
Blood.
•eras
2365
Blood,
•er»
2366
Hood.
••»•
EIPOSOBE ROOT!
Xngostlon
_
tlUTTICIl
HETBOD
Colorlnetry
US
IOBBEI
OF CUBS
•I 10
bl 5
1
•
2*
•1 3
bl 10
c) «*
d) «•
•I 3
0 «
BIEOB
a) 16.0-47.5 uiol/1
b) 27.S-V2.0 aaol/1
.
lot girea
a| lot given
b) lot gi*ea
c) lot given
d) lot given
•) lot given
•) 6-1* uole/1
b) 6-16 anole/1
e) 3-28 anole/1
d) «-25 ssale/1
•) 10-25 anole/1
f) 5-12 anole/1
(••XT
rati
a) 29.2 oaol/l
b) 36.5 aaol/1
130 ag/100 al
al 0.75 ag/el
b) 1.21 ag/nl
c) 1.00 ag/al
d) 1.12 ag/nl
•) 1.01 ag/nl
a) 11.0 naole/1
b) 10.* nnolo/1
e) 15.0 anole/1
1) 11.2 anole/1
•) 17.3 «aOla/l
f| 7.8 aiola/l
nan "
GIKUL IIFOHiTIOI
•t 10 pationti. «-18 re old
bl 5 patUati, 23-*2 re old
Data also foe P« binding and
at (oration
Pcogc«s«l*« Im loading with
Increasing ago.
Patlmts «ltk Call clinical flctac*
of B-thalaMamia intvrndia. 5
pnfiouly tran«(«Md ulth 2-15 oniti
blood, 5 pr«Tioa*lr tran»f«»«d «ith
25-*8 anita, 5 non-tranf o««d .
IRaLS; TlaCI BLBBBRS; IIOI; BLOOD
SII08; COBP1IHXTB STilOlTIOIS; aGB:
CRXLDIBIi IOOLTS: OBIIK;
BIOlCCOBOliTIOI; PICKS; OIITID
ITHDOR
l«*l«l
IIOI; IITIMl DISUSES; IIFBCTIOI;
BLOOD SBIOB
locnal rang* i» 60-160 ag/100 nl
•7-rr-old hou*>if« vita cardiac
(a line* of and«t«rnin«d caui.
DT«pn«a, fatigM, coogh
Onianal darkening of th« atkla.
cardiac daconoansation, abnonal
glacoM toltcaac* car**, dacngod
ll*«r faactloa, greatly inacaved
llTur icon atoces and klatolegle
Kttern coaal«t«nt >lta
•ochcoiatoal*.
itoit ciixroHXat mtu poisoinct
IIIBIIL IBTIMtXSIl BLOOD SBtOI; C1SI
BISTOIIES
a) «-6 ao lactation
b) 7-9 no lactation
c) 10-15 ao lactation
d) 16-21 no lactation
•1 22-31 no lactation
•kite (onaa. 2-30 no poatpactan.
ILOOD SBBOBl BILK; BHI; IBtlLS;
iiciiTioii CMCXOB; Mansion
IIKklBSII XMB| COPPBBl XIBC
a) 10-05 jt old •*!•, rltxrcT
Crossing
b| 10-<1S yr old faaal*. ritaroy
Ccossing
c) 20-<60 yr old nal«, Boiaajia
d) 20-«0 yr old faaala, Rovaaju
•) 60* yr sals, Fitxroy CrosaiBg
fl 60* yr old feaala, ritsroy
Crossing
BapreaMd saran iron in >50*.
Iboriglnaa, 5-77 yr old, fro a
Bovanjaa and Fitxroy Crossing
connnnltles of B.I. autralia.
BIOOD SBBOBl BLOOD FLkSBll XHC;
COPPBIi IBOBl BBTaUl I03TUIII1
tins; iai: CBTLDBIBJ IDH.TS i
i
IBFHEICE
Pippard, B.J.
•arnar, o.T.
Callander. s.T.
••atkerall. O.J.
1979
•ainbarg, E. D.
197*
Crosby, I.B.
Davsoa, i.D.
Bonck. P.B.
Born, E.I.
sacks, t.1.
Saltaan, P.
Tan, t.T.
197*
Tangaan, L.i.
laibsr. C.I.
Bsnbmllng. S.I.
1979
Bolt, I.B.
Spar go, B.B.
Xmson, J.B.
Faalknar, e.s.
Chaak, D.B.
I960
to
-------
Ito»
7«»-89-6
atl 55.817.
IP 153S C (pan), 1000-1300 C (east). 1500 C Inoagfct), 1300 C (staal), BP 3000 C, TP 1 aa Bg at 1787 C, 10 aa Bg at 20*0 C
ICORXBOBOI
nssn
2367
Bair
2368
Bair
2369
Rale
2370
(Idnay
uposnu toon
1B1LRICII
•moo
ii
us
us
X-cay spactroa
IOBBE1
OF CUB
11
•1 282
b) 202
8
12
11 MI
M-»7 ppi
a) 2.70-152.00 ag/9
b) 3.60-177.00 09/9
a) lot gir«n
b) lot gl»«n
e) lot gi»n
d) lot gifan
•) lot giT«n
•) lot glTaa
b) lot 9i»«n
1 M»V33 ppi dry «t
nanwt
ciimi. IIFOIUTIOI
Scalp bale
Boioca Ccoa 2 Tlllag«s of laika
Hdlana IB tb* tiaconas T«rcltorl«a
of T«a*«a*la.
HiiBj TBinoiui HETU.SI TIICS
IlMBRSl SODIOBj HOBUni SXlICOli
CBtOIIIBi PO11SSIOBI SCiBDIOC;
TKIIXOB: TIUOIOH! CRBOBIOBt OOtO;
B1I84IBSB; HOI: COBaLT; IICRI;
COPPB1; IIIC; USBIXCt SBLBBIORl
BIOaiBS; IOBIDIOBI snOIIIOBi SXLTBI;
IRIBOIT; lODnB; CISIOB; BIHOB;
llRBllOB; CBIIOB; SIBUIDBi BBBCOIT
*| Chllar»
b) Idalti
Cocr*latloo« bvtma F« aad th*
tolloiUig: hale coloc and •dacatlon
ot h«ad of hou«hold. Bale t» Ugk«r
li »ok*c* thai aoinokcri.
Iddltloial data.
Scalp hair. Caucasians IB IT. ag*s <1
to gcaatvr thaa 51 yr.
BR1LS; TltCI ILIBBITS; BaBIOBi
lOIOIl CIDBIOBt CBIOBTOB; COFPBB;
HOB; LUC; 1XTBIDB; BIBGIIESI;
iiicaiT; ncin.; snnxoBt sn»ti;
Til; tmDXOBj IIIC; BUB; 1CB;
IDOLTS; CRIIOBEI; SSI; COBP1UTITB
IIU01TXOIS; DOST; SOUS; til
POLLDTXOI; OIBkl 1IIISI III WBI
a) 1-6 ao lactatlofi
b) 7-9 ao lactation
c| 10-15 ao lactation
d| 16-21 10 lactation
•) 22-31 10 lactation
•hit* >oa«o. 1-31 10 poatpartna.
HOOD SBBOfli BXLBI BiXBi BBTHS;
1ICT1TIOI! CllCIOB; BlOIBSIOl;
BIIG1IBSB: XBOl; CCP7BB; XIBC
a) Hcdnlla
b) Coctax
2 aaaplaa par case. 2 an«lya«« par
aaapl*.
197« aatopalaa of 10 Plaa Indians, a
papago, and a craak Indian.
PCTissxoi: ciLcioa; HOB; COFPBI;
IIIC; IOBIDI08; IICKBL) LI1D: RRtLS:
TIICB BLIRBITS; LlfEB; SPLBBI; lOITi:
KIDIBTS; tOIPOSB TXSSOI; PllCISaS;
BnSOBBNBIT RRBODSi aOTOPSIIS
UFBIBICS
Parkona, i. I.
Talandla. J.».
Diana*. B.
1977
Craaaon, J.P.
Blnnara, T. t.
Baagarnar, J. s.
PlBlMCtOB, C.
1975
Taughan. I. i.
vabac, c.l.
(aabacllng, S.I.
1979
Rangalson. l.r.
Bill, R.I.
liaison, U.K.
Batongh, D.J.
Chclstansan. J.J.
Iiatt, g.R.
Blcharda. D.O.
1979
to
-------
Icon
7*39-69-S
Fa
kt> 55.8*7.
BP 1535 C (pecel , 1000-1300 C (caat), 1500 c (vronght). 1300 C (ataal) , B? 3000 C, »P 1 aa Bg at 1787 c, 10 aa Bg at 20*0 C
(COITIIOBD)
TISSOB
2371
Kidney
2372
Liver
2373
Liver
237*
liver
EIPOSOIE BODTE
Injection
Injection
klkLTTICkL
RETROD
ES
I-ray apectroa
ES
BOBBBl
OP CkSES
a| 135
b) 7*
c| 87
10
9
a) 91
b) **
cl 76
BkNGE
a) lot given
b) lot given
c) lot given
lot given
•230-32*00 «g/g vet nt
a) lot given
b) lot given
c) lot given
SBkl
a) 299 ppe
b| 29* ppa
c| 282 ppa
853 ppa dry vt
1*197.6 *g/g vet «t
a) MS ppn
b) 616 ppe
cl 520 ppa
GEIBBkL IITOIIkTIOa
a) lo renal diaeaaa
b) keate renal failure*
c| Chronic renal fallare*
Dry vt b**i*.
kotopiie* at OCLk Roapltal.
IliCB BLIREIIS; BETUSj kOTOPSIBS;
CkLIPOllIk; IIDIBTS; LITEIj SPLEEI;
DISIkSES; BIPBtTBISIOl; SODIVB;
fCTUSXORl CkLCXORj PROSPROIOS;
RkGIISXIIRi CkOIIORi lllCi COFPB1;
LlkD; IIOIl BklCkllSI; kLORIIOHi
snxcoi: TiTkiroR: coikiT; IICKEL:
BOLTBDRIOB; Til; CHBOHIOB; STBOITIOH:
BltlDR; LITBIOB: SILVBB: URkDIOB;
BOIOI
2 aaaplea per ca*a. 2 analyaa* on
each aaapla.
197* aatopale* of 10 Plea Indian*, a
Papago, and a Cceek Indian.
POTkSSIOR; CkLCIOB; IIOI: COIPEI;
tXIC; IOBIDIOR; IICEEL: LEkD; HEIkLS;
tikCB BLEBBITS; LITER; SPLIII; iOBTk;
IIDIETS; kDIPOSE TXSSVI: PkldlkS;
RIISOIBRERT BRRODS| kROPSIIS
Patient* (age* 5-21 yr| on 500 eg/day
aacocblc acid, 750 ag deafercionalae
B IR 6 daya/ak, 2 g deaferclcxa>lna
XT pec salt tranafaaed red call*.
Patient* *lth Fe overload fee*
ckcoalc tranataaloa tkarapy cf beta-
taalaaeeala.
IBOl; BETkLSj LITBI; OIIIB; BTIIBkL
ItTkBOlISB; OISBkStS; BBTkL
POISOHIG; COBPklkTITE BTkLOITIOIS
a) lo renal dlaeaa*
b| kcate renal failarea
c| Chronic renal failarea
al different froa b| and c| (?<0.01| .
b) and c) different (P<0.05)
Talae* ace dry vt ba*l*.
kotop*le* at OCLk floapltal.
tikci niRinsi RBTkisj iraopsxES:
ckiiFOiiiki nonrs] LI TEE; SPLEBI;
CISEkSIS; BTPEBTIISIOIt SOOIOBl
IOTISSXOI! CkLCIOBi PROSPROBDl!
BkensiOB: ckDBtoa: txici COFPBI:
LlkD) IIOIj BklSkllSE; HOBIIOBl
SILICOIl TTTkllOB; COBUT; llCMl!
BOLTBDBIOH; mi CBIOBIOB; snoinoi;
BkBIOB: LITBIOB; SXLTnt TklkDIOB:
BOtOI
UFERBaCE
Indrapraait, s.
klexander. G.T.
eonlck, R.c.
197*
R*ngel*on> l.f.
Rill, H.f.
lieleon, 1. 1C.
ta tough, D. J.
Chriatenaen. J.j.
Ixatt, I.R.
lichacd*. D.o.
1979
Pcoppec, B.D.
Skecln, S.B.
lathan, 0.6.
1976
Indrapraait, s.
klexander, o.T.
Gonick, I.e.
197*
00
(Hi* Mail
-------
Iron
7139-89-6
Itf 55.8«7. IV 1535 C (pin), 1000-1300 C (cut). 1500 C fnocgkt). 1300 C (it**!) . It 3000 C, T» 1 n Bg *t 1T8T c. 10 an Rg at 20*0 C
(CORXIOID)
TIS30I
2375
Ing
2376
tug
2377
Lug
2370
Ling
2379
LfBph
nod*
unsni loon
1
klalRXCU
IRIOD
IS
US
us
us
us
IUBBBI
or CUBS
30
20
•I 129
b) 15
13*
i«
MIOB
25. 2-3165.0 ag/g dry «t
lot gi*«n
*} 2.0-4.3 sg/g dry «t
b) lot gi»«n
2.0-».3 ng/g dry »t
lot glv«n
(«trr
mi
lot glran
1998.0 ng/100 g trj
it
n) 2. 9 ng/g ACT •*
b) l.» ng/g ACT nnd
lynph nodi* of long, additional data
atallabl*.
Snctloa* of lingn fcon «nbj«ctn nho
bnd b««n bitaninou coal niaun foe
12-50 yc In tal«lgk Conatr. mnt
flcginln.
BRaLS; TI1C1 BtBBBITSs COIL;
iimtioi; coBiiT; cnoixoBi COWBI:
iioi; tiiD: Btaiisxoi; BkiaansB;
IICML: TXTIIIOI: TII1DIOB; IIIC)
inias: COHPIUTITS BTHOITIOISJ
SniCt; ODtm; ITBPI lOOISi 1BST
flieiBIa
a) Coal nin P.
•olovin, r.l.
1971
K«*nan, B.C.
crabl*. J.T.
Snallnood. ».».
Carlbvrg, J.I.
1971
to
vj
VO
-------
Icon
7139-89-8
Fe
»t» 5S.8»7, HP 1535 C (pur*), 1000-1300 c (call). 1500 c (nought), 1300 C (steel!, BP 3000 C, IT 1 •• Bg at ITS'* c, 10 •• Bg at 20110 C
(C01TI1DED)
TISSOE
2380
Bilk
2361
Bilk
2382
Pancreas
2383
Placenta
23«»
Splmn
BXPOSOBE BOOTS
tHLTTICtL
BtTBOO
us
US
X-ray apactroa
....
u
-
I-ray apectroa
•OBBBB
OF CISBS
a) 26
b) 39
c| 23
d) 13
e| 29
f) 30
IS
•
8««
8
HUGE
a) lot given
b) lot given
c) lot given
d) lot glien
•) lot given
ft lot given
0.26-0.73 ug/al
lot glTan
lot given
lot given
HEIR
a) 0.»9 * or - 0.05
ug/al
b) 0.»3 » or - 0.0*
ng/al
c) 0.»2 * or - 0.06
og/el
41 0.38 » or - O.OS
ng/al
a) 0.39 » or - 0.09
uq/al
fl 0.»2 « or - 0.08
ag/al
O.«1 ng/il
205 ppi dry >t
T3» • or - 23» 09/9
3(51 ppa dry «t
GtlBBlt IIFOBRttlOl
a) 1-3 10 lactation
b) 1-6 ao lactation
c) 7-9 10 lactation
d) 10-12 10 lactation
e) 13-18 ao lactation
(I 19-31 ao lactation
•hit* •oien, 19-«2 fr «ge, 22
prlilpara* and 16 lultlpara*.
HOOD SBBOB; NltK; HBTU.S; LICTaTtOI;
Rl»; CllCIOH; laGIISIDH; MRalBSB:
IIOI; COPPEB; XIIC
0.1-19 ao poat partaa. 15-a6J bound
to lipid fraction.
Baaltby 3«edi«h aothera.
8ILI: IIOI; BBTILS; S11DII; TRaCZ
IICHER5
2 aaaplaa per caae. 2 analyaea par
aaipl*.
latopalea of 10 Piaa ladiana, a
capago, and a creek Indian.
tOTlSSTOB: C1LCIOB; IB01; COPPBBJ
SIIC| IDBIDIOli IICKBL; LEaD; BBI11S;
T11CE BLBHEITS; tlflBt SPLEII; lOITi;
KIDIEIS) IDIPOSB TISSOB; PalCBIaS!
BItSOIBBBIT BETBODSJ aOTOFSIES
Oir *t baala
saaplea froa a hoapltala in
laahfille. tl.
PLaCBITa; HBIiLSj MICE BLBBIITS;
tEBBESSBB; BlOOOi BlIBj COBPlllTITE
BflLOlTIOIS; BICail; IB4D; UDHOB;
StLBBIDB: IOUDXDI; IBO1; UK;
COBalT
2 aaaplea per can. 2 analyaea on
each Maple.
197* aatopaiu of 10 Piaa Indiana, a
Papago, and a Creek ladian.
lOTaSSIOl; CUCIOl; IIOI; COFPE1:
UK; BOBIDIOBl IICIELJ LE1D; BBTaLS;
TIICB BL1HEITS: LUBB; SfLEBI; kOITl;
IIDIBIS; tDIPOSE TISSOBJ PalCRBIS;
BUSOBBBBBT BBIBODSJ aOTOPSIU
BEPEBEICE
Tanghan, L.I.
teber« C.V.
Keaberling, s. B.
1979
Franuor, G-B.
Lonnerdal, B.
1980
Bangelaon, I. P.
Bill, B.».
lielaon, K.K.
Eatoagb, D.J.
Chrlatenaen, J.J.
Iiatt, l.B.
Bicharda. D.o.
1979
.
Baglan, B.J.
Brol, l.B.
Schalert, a.
lll»on, D.
Laraen, K.
Dyer, I.
Banaonr, B.
Scnaffner, *.
Boffaan. 1.
Dalles, J.
197*
Bangeleon, B.P.
Bill, B.B.
lielaoa. 1. 1C.
Eatoagh, o.J.
Chriateuea, J.J.
Iiatt. l.B.
Bicharda. 0.0.
1979
00
O
(1EII P18B)
-------
Icon
7*39-89-6
Ut 55.8*7, Sf 1335 C (para), 1000-1300 C (cut), 1SOO C (nought), 1300 C (*teel), tf 3000 C. >P 1 aa Bg at 178T C, 10 •• Sg at 20*0 C
(COITX HID)
TISSOR
238S
Spleen
2388
oelne
2J87
orine
2388
Oriae
BIPOSDBB IOOTI
Ing* *t ion
inimcu
BETBOO
ss
us
us
IDBBBI
or CISBS
•I «o
b) *•
C| 76
12
1
5
__— ^^^^ _ _
•USE
•) lot git*B
b) lot given
c) lot given
.- _
a) 3.29-40.3 19
b) 6.*-65.2 «g
(ot applicable
0.2-0.6 ag/2* hr
("BIT
BE*!
a) 730 ft*
b) 887 pp>
c) 802 ppa
a) 16.3 ig
b) 31. • ag
58 Ig/100 ml
O.t ag/2» hr
1
1 — _.
Pisei
GBiniL iirotunoi
•) lo r«aal dlM«««
b) acute r«al failarai
c) Chcoaic noal (altarM
a) and b) differrat, p<0.05
ValM* ara otj lit but*.
iitop«l» at OCLI itnpltal.
IIICB niMRs; musi IOTOPSIBS:
CltirOIIIal KDIKTSj Itnit SPIBB«!
OIS11SB3; BIPBTEIIIOI; SODIBB;
tottssraii cuczoii FBospBoira:
BaaiBSiai; C1DBIOB; H«Cj COIPIIi
tliDi noli UlSaltSBt ilOBIlOB;
snicoi; Titmaii COBH.TJ IICKBL;
aoiiBDMOB: til: CBIOBIOB; SIIORIOB;
BIKOB; lltBIOB: SU.TEI; falaDIOBi
(0101
a) IB lojactlon
b) SC Injection
«8 hr aciaaa b«(oc« tiaMfaaloa.
a(t«r 750 ag 4««f«rcioiaalBa «aa
gl»«tt to 9 patlanta. lualta slallar
1 or 2 day* a(t«t cootlm bleat
traufmloa. Incctuiag iaf ••! doM
to 1500 ag Inccaaaaa aicr«tlc* an
a»«tag« of «29I la 6 patlvnt*.
11 patiaat* »ltk tbaUawala, ag*a
6-17 ye and 1 Kith congenital
aldcroblaatic anaala, age 25.
HOI; OlItBD KXIODOI; Oil IB
•8 he after idaiulon.
2« js alt black loaan adaittad to
Bontefiore Boapltal. In Plttabnrgh,
(ollovlng infection of 10-15 fecroaB
aolcata tablata (3.0-B.S g) .
laoaea, »oaltlng, geaecalKed
xakneaa, hyfoactita bo«el •conda.
bloody atool
llld tachycardia, inverted T Kama in
precordlal lead* (tco)
KTlLSi HOI; BtOOD SBSOB; OHIB:
IBOLfSl CaSI BISTOIIBS; SOrCIBB;
CtllSTLTiltt
toaltlM re balance of 2.6-8.6 ag/dar
(cogreaaife re loading Kith
iacreaaing age.
Patient*, 7-2« jc old, Kith fall
clinical picture of B-thalaaaaeaia.
3 pce?io««ly tcanafaaed Kith 6-25
onlt» blood, 2 noa-tran*fa*ed.
BITUS; TMCE ILBRBITS; tlOl; BLOOD
SIIOH; COmUTIKB BT1L04TI01S: 1G«:
CBILDBBK; tOOLTSj OBIIB;
HO»CCDBOI«TIOl! PKCES; OIITIO
XIMDOB
BBrtUICB
ladrapraait, S.
tleiandec, o.f.
Oonick, B.C.
197*
•main, a.t.B.
Green, 1.
riynn. D.B.
Boaaain, s.
1976
Vallack, B.K.
•inkelateiB. a.
197»
Pippard, B.J.
laraer, G.T.
Calleader, S.T.
featherall, D. J.
1979
NJ
00
-------
Iron
«39-8»-6
PI
It! 5S.8»7. HP 1535 C fpnce) , 1000-1300 C (cast), 1SOO C (nought), 1300 C (steel). BP 3000 C, It 1 » 89 at 1787 c, 10 » ag at 20«0 C
(COItHOBD)
TISSUE
2389
Ocine
-
2390
Oclne
BZPOSOIB IOOTB
Injection
Ingest ion
Ingest ion
alaLTTICIL
RBfROD
US
US
IORBB8
OF CaSBS
10
12
ItlGE
a) 3.«-35. 1 ng/2« bt
b) *1. 1-150.0 ng/2» hr
c) lot given
a> lot given
a) lot given
b) lot given
mi
a) 19.2 eg/2* hr
b| 66.9 eg/2* be
c) 20.1 sg/2» be
d) 60 eg/2* he
a) 0.15 » or - 0.01
sg/day
b) 0.20 • or - 0.01
ng/day
GEIEB1L IIPOIIaTIOl
a) aftee 750 ng desferrloxailno B 18
b| iftar a g desferrioxaslne «ith
transfnslon of ced cells
c) 1*-yr-old girl. 750 sg/dai
desferrloxanine IH
dt Sane as in cl bat by 2*-he IT
infusion 2 days
Patients In a) and b) »ere ages 5-21
yc on 500 ng/day aseocbic acid. 75 o
ng desferrioxaslne B II 6 days/nit, 2
9 desfercioiaalne IT per unit of
tcansfaaed ced cells.
Patients >ith Fe overload fees
chronic tcansfesion therapy ef beta-
tbalasMela.
HOI; RETILS; LITBI; OIIIE; (IIBUL
BIT1BOLISB; DISBaSIS; MTIL
tOISOHIO: COBPMI1ITB BT1L01TIOIS
a) to« fiber diet plos 21.8 eg Fe/day
foe 26 days
>) Bign fiber diet pl«s 26.* ag
Pe/day foe 26 days
Bean » or - S.B.
Sasples collected derlng lest 7 days.
Balance date available.
37-58 yr old een
RITaLS; TBaCE ILBIBITSl BIIEI1LS;
OIIIBI tOOLTS; FBCISi CUCIOB;
EaGIBSIOR; I noil sntCOl: cOBPMaTITB
miOHIOIS; OIBtS; FIBB1S;
BltaBOtlSBIS RUIUID
IEFEBEICE
Propper, 8.D.
Shatln, S.B.
lathan, D.G.
1976
_
Kelsay. J.L.
Behall, K.a.
Feather. E.s.
1979
to
00
to
-------
laoaipacotic acid, 1-aotfcyl-B-pbanrl-, *tkyl ««t« (B CX)
a-flpaciainacacboxiUc acid, 1-Botkjl-a-pBBBrl-, «tkjl ««t«r C9
C1S-U1-I-O2
II 2*7.35. If 1W-1B9 C
TISSBB
2391
Blla
2392
Blood
2393
Blood
239a
Blood
2395
Blood
BBOSOU BOOTI
Ingaatloa
Inject loa
Injection
Injection
Injection
IB1LRXC1L
BBTBOD
OC
OC
OC
oc
BOB Bra
OP CUBS
2
11
13
«> 21
b| 13
10
UMB
0.9-1.3 ag/100 al
0.1-2.0 ag/100 al
0.01-11.0 ng/Bl
a) 11-162 ng/Bl
b) aO-99 ng/al
0.7-3.0 og/Bl
(BEIT
niB
1.1 ag/100 al
0.58 ag/100 ml
2.5 ng/al
a) 95 » oc - *3 ng/al
b) 6* » oc - 22 ng/al
lot glfan
PIUBI
OBBBBU XBfOMMXOB
Badlcal aiaalaac caaaa of dattka (COB
tntaatloaal oc accidental 00. oc
nadetacalned oc aatacal caaaea.
CBOflSl lOTOPSIBS) nPMXDXBIS;
snciDBi BLOOD: 01IBI; UVIBi BIUj
EBOQ MUSI
Badlcal eualnac caaea of death* tcoa
lataatioaal oc accidental on. oc
OlflttS! tOTOPSIBSl IBPBBXDXBBS;
SOXCIDIl BLOOD! OBXBBl II TIB J Bill;
DBW IB03E
Daatk caaaad by dcag coablnatlona
Bacocda of 1239 daataa In 0.9. and
Canada. la all. dlasapaa oc Ita
aatabollt* can pcaaaat In the
tlaaaaa and. It Boat caaea, aoca tkan
one dcag aaa foand. Igaa: leaa than
5-9natac tkan 65 yr. Blgk tcagaaner
of aalcid*. Other data available.
Palaonacy and tlacacal congaation
noat CQBBOB poataoctaa finding
D108S; DB08 1BOSB; ClflD*; 01ITBD
SItTBSi OMB; SBD1TITB5; BTPBOTICS;
PSKBOTBOPXC DBOOS; BLOOD) LITBBi
KXDBBTS; U.COBOLIC BE* BI1SBS ;
POBBBSK BBDICIBI
a} Tenoia clnapad aablllcal coed
blood at blctb
b) Icterlal claapad aablllcal coed
blood at blcth
Lavele decreased aa dcag-blcth
Intecrtla laccaaaad.
30 neonatea >hoae aothaca cacalvad SO
ag aapacldla* lntcannoo*ly daclag
laboc. aotkaca iltkoat ll»ei oc
kidney dlBaaaa oc dcag addiction, 1»
Black, 16 Bklt*.
DBOOS ; PBBQBIBCT; BLOOD; OBIBS;
BITiBOLXTBS; OBIOJ OBBILICIL COBD;
BIBBOBB
Bang* of aeaa* 10 and 260 nln
poat-lnjactlon. Batlaatad fcoa
gcapb.
Pcegnnnt patlaata at taca. aota 15-28
yc, vltkont llrer oc kidney dlaaaaa
oc dcag addiction.
D100S; PIBOBIBCT; BLOOD; BBTIBOLITBS;
OBIO| DIDO TBBBtPT
BBPBBBBCI
Slak, T.J.
1978
Slek, T.J.
1978
Tinkle, B.S.
BcCloake;. (.L.
Soodaan. L.S.
1979
(aknoct. B.B.
Kaknect, P.B.
Ta. l-S.L.
LIB, D.C.K.
1979
Kahnact. B.I.
Kaknect, P.B.
Ta. l-S.L.
Lin. O.C.K.
roltz. S.L.
1979
00
to
-------
Isonipeeotic acid, l-aethyl-t-paenyl-, ethyl eeter (8 CI)
»-Plperidlnecarboiyllc acid, l-eethyl-a-phenyl-, ethyl eater (9 CD
57-»2-1
C15-B21-1-02
n» M7.35, tt 186-18» C
(COITIIOED)
TISSUE
2396
Blood.
plassa
2197
Blood.
plasaa
2398
Blood.
plant
2399
Blood.
<«ra>
2100
line
MPOSOHB BOOTS
Injection
Inaction
Injection
Injection
Ingest ion
IBjeCtion
lULTTICkL
BETROD
EC
1C
-
oc
oc
oc
IOBBEB
OF CIS IS
a
«) 1
b| 12
3
12
9
B»OB
•I 0.019-0.093 ng/el
b) 0.011-0.18 ag/el
a) 0.»S-0. 08 ag/al
b) 0.8-0.07 ag/al
1.21-0. IS eg/al
a) 1«0-«0 ng/nl
b) 120-18 ng/nl
..
0.2-3.0 (9/100 g
(BER
HEH
«) 0.053 ag/al
b) 0.073 ag/al
..
*| lot applicable
b) Bot appllcabl*
lot applicable
al lot applicable
b) lot applicable
1.02 eg/1009
FIGE)
GEIM1L IITOlRaTIOl
a| Coed veooo* plaeea at delivecy
b) aatecnal Tenoee plasaa at delivery
Ccegoaot voeea, 16-30 ft old fro«
Sydney, aeetralia, in 33-«0 ik of
geetatloB.
DIOOS; BLOOD PUSfll: PIEGBIICT:
IQSTBILH
a) Ion-pregnant
b) fcegnant
5-210 eln after SO eg XT. Decline
bleiponeitial. lo difference in
kinetic paraeeter*.
Patients «ho had drag daring labor,
and neonatea. lonpregnant (en lea, of
child bearing age, itadled early in
lenatcaal cycle.
DIOOS; RETIBOLISI; HBOIIICI;
IIIBOII; tlU«BSXCS; BtOOD PUSSl;
IITkBOHTESs COBPIHTITB EfklOkTZOIS:
01X11
0 and 300 ein after 0. 1«3 ag/kg XT in
2 aln. Bleiponential decliaa.
loa-aaokece althoet recent hepatitis
or eiposare to nedicatione, aboet 21
yr old.
DIOOS; UlCOtlCS; BLOOD PUSBl;
ICOLTS; CaLXtOtllt; COIPtllTITE
EftLOaTXOIS
a) laage of aeane 1 and 8 ar after 30
Bg/*g a IB of the hjrdrochloride.
Initial »alee. 112 ng/el at C.S hr
b) Controls, lange of aeana 1 and 8
hr after 30 eg/eg B IB, placebo.
Initial valae, 116 ng/nl at 0.5 he
Both groape (retreated 1* daya vith
(beaobarbltai or placebo. 32.S ag
t.l.d. Clearance coaplete at 2* he.
Bedlcal atedeate, ages 21 to 30 yr,
eithln 10* of ideal Might, tlthoet
recent history of taebitieate aee.
DIOOS; DIDO THBItrt; •IPEIIDIIE3;
BtTlBOHSB! HICOTICSl HOOD SnW;
OHIEj IET1BOLITES; COBPlIkTCTE
11UOMIOIS
Bedical ezaainer case* of deaths f COB
intentional or accidental 00. oe
endeterained oc nataral caues.
DIOQSt tOTOISIBSl BIPEHDIIB3;
SOICIDBt BLOODl OlIBBl LXTEBj BUB;
BIOS IBOSC
BEFEB2ICE
•organ, D.
Booee, c.
Thoeas, J.
Tclggs, E.
1978
Kahnert. B.8.
Itahnert, p. a.
Prochaska, B.s.
Sokol, a.J.
1980
Fang, D.L.
•sling, J.8.
Blsele, J.H.
Bertacci, 1.
1910
,
steBbeagh. J.E.
teiaee, X.f.
Schwartz, t.
1976
Siek, 1.3.
1978
N>
00
-------
laoeipecotlc acid. 1-»ethyl-«-pheayl-. ethyl eater (a CI)
»-PiperiaUecarbo*ylic acid. 1-aethyl-a-phenyl-. ethyl eater (9 CI)
5T-M-1
C15-B21-I-02
If 2*7.35. If 186-189 C
(CORIfOBO)
TI3SOE
2*01
2«02
Orlne
2*03
Urine
2*0*
Oeiae
— -
BIPOSOM 10DTI
Ingaation
Injection
Injection
Inject ion
Injection
imnicu
BBtHOD
OC
OC
oc
oc
IOBBBI
OP CiSBS
5
30
«5
12
ItIBB
0.2-5.0 ig/100 al
0.5-1*. 25 09/19
creatinine
a) 2.6-0.05 ag/ag
creatinine
b) 3.25-0.35 09/19
creatinine
c) 3.35-0.125 ag/ag
creatinine
d) 2.20-0.5 ag/ag
cceatinlne
e) B. 65-0. 75 ag/ag
creatinine
f) 2.2-1.3 ag/ag
creatinine
a) 0.67-3.49 ag
b) 1.05-7.30 ag
c) *.1*-1*.«0 ag
d) «. 19-13. 10 ag
BBtl
2.28 eg/100 al
lot given
a) lot givea
b) lot gi»ea
e| lot glvea
d) lot glTen
e) lot given
f) lot givea
i| 1.67 ag
b) 2. 88 19
c) 8. 58 19
4) 9.29 ag
eiiBUi iiPoiRinoi
ladical enaiaer caaea of deaths froa
iatentlonal oc accidental OD, or
aBdeteraiaad oc nitoril caaaaa.
OIBOS; IDTOPSIBSj BBPBUDIIB3J
SOICIDX: BIOOD; OIIIB: LITBI; BUBS
DIOO IBBSB
La«ela dariag first 3 days of life,
eatlaated froa graph. Level Tided
•1th day of collection aad drag-birth
ID tern 1. Clearaace froa necnate aot
coapleted at 3 daya. Botheca
received 50-ag dose dicing labor.
DBOOS; PIBOIMCTl BLOOD; OIIIB;
BtTiBOLHBS; OBIOs OBBIUCA1 COID;
III BOB)
a) Bepecldiae, poat-partaa pitieata,
12 Bad 72 hr after 50 ag
b) aoceepecidlne. post-paxtaa
patients. 12 and 72 hr after 50 ag
aeparidiaa
c) Beperldlie, coatrols, 12 and 72 hr
after SO ag
d) loraeperldiae, controls, 12 and 72
he aftec 50 ag aeperidlne
e) aeporldlBo. neonatea, after SO ag
to aethers, 1-3 daya poatpartaa
f) loraeperidlne. neonates, aftec SO
ag aepecidlne to aothera, 1-2 daya
Boatpartan
12-hr uiaea
Patieats »bo had drag dariag labor.
and neonatea. loapregnant feaalea, of
child bearing age, stadied early
aaaatraal cycle.
DB003; iBTaBOLISB; PBIQI1ICI;
IIIBOIII kllLSBSICSS BIOOD PUSBI;
BRtBOUTIS; CORPIIaTITB BTlWlTIOIS;
OIIIB
•) phenobartital-pretreated
c) Placebo-pretreated
c) PheBObacbital pretreated, valaea
are aepecldlalc acid
d) Placebo-pcetceated. valaea ace
aaperldialc acid
•8-hr coiilitlve orinei aftee 30
ag/aq a IB Repecidlne-BCl.
tretceataeat aaa 3X32.5 ag/day
pbenobarbltal (oc placebo) 11 daya.
Bedlcal stadenta. agea 21 to 30 yr.
aitblB 10S of ideal wight, .itboot
recent hlatocy of bacbitacate aae.
DBOOS; DIDO TBBIaPI: BBPBIIDIIBS;
BITlBOLISB: IIICOTICS; BIOOD SEBOB;
OIIIB: BIT1801ITES; COBPaBtTITB
EfalOlTIOIS
UTBUICB
Siek. T.J.
1978
connect, B.B.
Kahaect. P.I.
to, »-S.L.
tin, D.C.K.
1979
Kahnert. B.I.
Kahnart. P. B.
Prochaska. B.S.
Sokol. B.J.
1980
Staabaagh. J.t.
•aiaec. I.I.
Schaactx, I.
1978
to
oo
Ln
-------
Xaonlpacotlc add, »-pkenyl-. atkyl eatec (8 CD
«-PlpacldlnecacboxTllc acid. *-pk*nyl-. (thy! ester (9
17-17-8
CW-H19-B-02
Bl 233.3*
TISSOB
2»0 S
• 11*
2*06
Blood
2«07
Blood
2*08
Blood
2109
Ll»ec
2*10
Vrln*
BXPOSOBI BOOM
Ingest loo
Injection
Ingest Ion
Injection
Injection
Injection
Inge at Ion
Injection
Ingest Ion
Injection
I MLYTXCM.
BNHOD
OC
ec
GC/IS
OC/HS
OC
OC
BORBB1
Of CISBS
2
11
a) 13
b) 10
12
9
5
UfOB
1.0-1.6 19/100 nl
0-3.0 ig/100 •!
a) 5-36
b) 2-«2
0.003-0.022 ug/al
0-6.6 19/100 9
. ._ -
0.01-7.9 ag/100 nl
(HIT
mi
1.3 if/100 «1
0.67 19/100 nl
n) 17 « or - 1*
b) 15 » or - 13
lot given
1.73 19/100 9
«.oa 19/100 ni
HOB)
GBBBI1L IlfOlltTlOl
Badlcal eiaslnac CIMI of de«tks Icon
Intintlonnl oc acclatntal 00, or
•nd«t«rilMl oc nntactl cnnsa.
CIOOSJ lOTOPSIBS! BEPBIIDIIB!;
30ICIDBJ BtOODj DIXR; HTBBj BUS;
DlOa IB03B
Bndienl •rinlmc cui* of d«ttk< fcon
lnt*ntlontl oc •ccUnntal OD, oc
•nd«t*cnlMd oc nntacnl ciaicn.
OBOOS; tOTOPSIBS; BBPB1IDIIB!:
JOICIDBi BLOOD; OillB; LlfBBj BXIB;
DI08 IBOSB
n) T«non« clupcd anblllcnl coed
blood «t blctk
b) ictwlal clnipid ublllcnl coed
Blood at blctk
l«nl« nnnlttcd to dcig-blcth
IntwfnlB.
30 MonntM ihOM noth«c< c«onlt«d 50
ng ••pccldln* lntca**noulr dicing
labor. lotlMC* vltkovt ll*«c oc
klda«r dlMaM oc dc«9 addition, 1*
Black. 16 Iklta.
OID03I PlIflMKX! BMOOl OKU!
BITIBOLITIS: ORXOl OUXUCU COBDi
insoii
Bang* of Man* 10 and 260 Bin aftoc
single Injection of SO ag Mfacldln*
daclag laboc. Eatlaated fcon gcaph.
Pcegnant patloata at tern, ages 15-28
is, »ltkont llvec oc kidney dlaeaae
cc dcng addiction, ultk long
dcag-blctk Intecfala.
DBOOS; PBBailKTi BLOOD; RITUOLXTES)
CBIOl DIOO TBBlkPT
ladlcal exaalnec earn* of delta* fcon
Intentional oc accldeatal OD, oc
aidetecntned oc natacal caaaec.
DBOOS; tONPSXISt UMUDXIISl
sncXDI) BLOOD; DBIBS; LI TIB I BXLI;
DIM 1BOSI
ladlcal asaalnec cues of iettk froa
Intentional or accidental OD, oc
andetecalBed oc aatacal caues.
DBD9S) 1«TOPSH3| HIPIIXDIIISl
3DXCXDB; BLOOD; BlIK; LXVIB; BXLI;
BIOS 1BOSI
BBrtlBICE
Slek, T.J.
1978
Slek, T.J.
1978
Kuhnert. B.B.
Kaknect, P. a.
T«. n-S.L.
Lin, D.c.R.
1979
Knkaect, B.I.
Knknert, P.I.
ta, k-S.L.
LIB, D.C.I.
Polts, I.L.
1979
Slek, T.J.
1978
Slek. T.J.
1978
to
00
-------
laoaipaeotic acid, a-pkaarl-, «Ufl aatar (8 CX)
a-PlparldlaacaEboxrllc acid. «-pkBayl-. «tkyl «»tar (9 CI)
77-17-8
CW-B19-I-OJ
•I 233.3*
TISSOB
2*11
OElaa
2*12
Oriaa
•icosnii lane
iBJCCtlOB
iBJCCtlOB
IIIHTXCIL
• RIOD
OC/BS
ec
IOHBBI
or ctsis
30
12
HIKE
0.6-3.75 ag/mg cnatlaiBi
•I 1.31-1.10 •«
b) 0.79-2.37 if
c) 3.02-9.75 19
4) 2.16-6.51 »g
ati
lot gl»«B
•) 2.»3 »9
b| 1.60 19
c) 7.03 if
4) «.33 *g
ctiBiiL uraiiHioi
Itnls 4|[iBg firat 3 day* at life,
•itl»t«4 fro« grapk. &•*•! »Bri«4
•1th 4»y of calUctloB ud ing-bltth
iBtBETll. ClMEIBC* fCOB BCCBBto BOt
coipl«t« at 3 4«y«. Both«r> r«c«lT»4
50-Bj del* Mp*EldiM dariig labor.
DIOOSl riBOIKCT: BMOD; Oil IB!
BRtBOLITES; OBXO; DHBIUCll COIBj
IIIBOII
a) Pk«Bobarbital-pntc«at«d
fe) Plae«bo*pc«tc*at«4
c) Pkcnobacbltal pntr«at«d« »alu««
an iOEa*[MCi4lBlc add
d| Placvbo-pcatcvatvd. *ala«a ac«
DCCMp*Cl4lBlc acid
•6-hr caialatlT* niiB«a aft«r 30
*9/»q a II Mpacldla*-BCl.
Cntraatnat via 3X32.5 ig/dar
pkaaobacbltal foe plac«bo) 1« 4aya.
Radical ata4«Bt«, agw 21 to 30 jr.
•Ithla 10* of Idul mlgkt. dtkoat
c«c«at klitocj of barbltacata •••.
OlOaS; 0100 THII1PI; IBPB1XDIIBS:
IIT1BOLI3H; ItlCOTICS; BLOOD SBIOB;
OIIII; BBTIB01XTB3; COBP1IATITB
H1LOITIOIS
IBrBtBICB
KakBCEt. B.B.
Kikaact. t.n.
Ta, »-S.t.
LiB. D.C.K.
1979
Staabaagh, J.B.
lalaac. X.I.
Sckcactx, X.
1978
ro
oo
-------
HoqainoUn*, 6.7-di«»tlio*f-1-»««tryl- (8 CI)
Iao4»lnolln«, 1-((3,»-di««tboxrph«Tl) Hthyll -6,1-di.Mthoiy- (9 CI)
58-7»-2
C20-B21-I-0»
Bl 339.38. SP 1*7 C
TISSUE
2«13
ocln«
BIPOSOIB IOOTB
XagMtion
mi. men
SITBOD
oc
ROBBEB
OF CISBS
5
BUGS
tl Rot gi»»n
b) lot glun
c) Bat gl»«n
at 17.9 <
b) «8.S <
e) SO.9 t
GIIEB11 IBFOBBHIOB
.
• 1 2 he
t) 2* hr
e| «8 he
total CMtlativ* •icntion of
••tabolltM «pc«*ml aa p»o*nt of
100-19 AOM.
CBOOSi OBIBI) BmBOLITBS
BBFB1BICB
Bogaiet, a.s.
1978
N>
00
OO
-------
«00
12737-87-0
met coRFOsxnoi oinon 01 OIDRBIIIIBD
TISSOB
2*1«
Blood
2*15
Lang
BIPOSUBB IODTB
-
Ingactlon
XBg«*tloB
illimciL
RETROD
108 BIB
or CUBS
•1 202
b) 65
0) 16
4) 6
7
Ik KB
•) i-« ppb
b) 5-9 ppb
c| 10-19 ppb
4) 20.31 ppb
1-31 ppb
ran
a) tot gl»B
b) lot glraa
c) lot gir«B
4) lot gl««D
lot gl»n
BIIBUL IBFOIBkTIOB
B««14«Bt« Of Mat* CD Japaa (ag« 0-80
IC| «kO conaaMft an av«cag« of 800 Bl
of bcaa oil oontuln>t«4 cltt 1000
ffm tCS'm.
l«*plntocT
.g., ooigklig,
cotr«l«t«4 «Itk blco4 KB
LyipkocTt* ioflltr«tlo» ID bEonehlal
»4 bcoiohlolu »!!• u4 iiccophag*
liflltratiOD la alnoli. Fool
«d4/ot palionacr «4«H *B4
*Bd pnlctEdlal •ffiiion or
•4huloB ob««r»«4 IB 3 p*tl«Bt«.
IOIOS; BLOOD; CkSB BISTOBIBSj
(CIICBLOIIIlin BIPBHTLS
oaghlBg.
Itsplntory (TiptoBc («.g..
•ipcctocBtlOB, »n4 «k*«xlng
cocc*lat%4 ulth bloo4 KB
tl«phocrt« lotlltration IB bionchl*!
•nd bEOBohlalBC •*!!• «B4 iBaopbog*
iBflltcBtloB IB alnoll. ?oc«l
h«Bocth*g« >D4/oc pvlaonarr «4«M «nd
pl«>CBl BB4 p*tiC*EU«l •ffatlOB OE
*4k««loB ob««»«4 IB 3 patients.
IOIOS ; BIOOD; C1SE BISTOBIBSt
poitcaioiiiitEB Binnns
•BFIBIICB
SaiqcBatsa. I.
Iikliara, s.
Salto. 1.
Ik*4a. T.
Ratllba, I.
Saglyaaa, t.
Ba«a4a. T.
1978
ShlgoaatSB. I.
lahiaarn, S.
Salto, B.
Ik«4a, T.
Bataaba, I.
SBglnia. K.
Raraia. T.
1978
ISJ
00
VO
-------
l-ascorblc acid
50-81-1
C6-B8-06
•« 176.12, HP 190-192 C
TTSSOB
2«16
Blood.
colls
2*11
Blood.
coll*
2118
Blood,
colls
SXPOSOBB SOOIB
Ingostlon
Ingostloa
Ingostloa
IBaLRXClL
BBT800
IDB
or ci
a) ««
b| «2
cl 11
d) 11
20
18
BOBBEB
or caSBS
» »6
» »2
:l 11
I) 11
20
18
II BOB
a| 16.2-S4 U9/10(B»8|
colls
b) «.2-2*.7 ag/10(B»8)
colls
c) «.2-l 7.1 ag/10(B»e)
colls
d) 8.6-21.0 ag/10(B*8)
colls
» Bat gifoa
b) Bot glton
c) Bot glToa
d) Bot gi*on
o) Bot gl*OD
f) Bot given
g) Bot glTon
h) Bot giToa
1) Bot gi*OB
]] BOt giTOn
k) Bot gl*on
1) Bot gi»on
*) «-»0 ag/10(B«8) colls
b) 7-50 ag/10(B»B) colls
c) S-«5 ag/10(B»8) colls
d) 56-90 ag/10(E»8| colls
(I BIT
8MB
«) 31.5 ag/10(E»8)
colls
b) 11.2 ag/10(E»8)
colls
c| 10.7 ag/10(E*8)
colls
d) 15.1 ag/10(E»B)
colls
•1 22.3 ag
b) 29.6 ag
c| 33.0 ag
d) 31.8 ag
o) 32.6 ag
(1 29.0 ag
g) 22.* ag
h) 3*.« ag
1) (0.3 ag
1) 32.7 ag
kl 35.5 ag
1) 35.0 ag
•I 2«.0 ag/10(8»8|
colls
b) 25.8 og/10(B»8)
colls
c) 22.0 ag/10(E»8>
colls
d) 65.5 ag/10(B»8|
colls
HOB)
OBBBBll IBFOBBHIOB
•) Contrail, sgos 19-55
b) Contrail, tgos 59-97 (long-star
gociitclcs)
c| GocUtclc potlonts bofoto Tltailn
C tkocopr
d) aoclcttlc potlonts at 1 g/d*y, *
•k
Cat* glron foe placobo groopi.
long-star patients, agos 59-97, in 2
goclatclc hospitals In England. •«
Hood-donor controls, agos 19-55.
Clinical IspcomaoBts and voigbt
gains In tbo Tltaain c gcoap.
tmaiBS; »01; OBITBD IIBODOB)
DISBISBS; ISOBOCTTBSt MOLTS; BLOOD
fUSB.I COBriBiTITB BVkLOaTXCBS;
DIRS; BOTBZTIOBIL DETICIBBCIBS;
BOTBITIOBlL DISOBDBBS
_
a) Balos - 0 hr daring cold
b| Balos - 2 kr daring cold
c) aalos - 1 kr daring cold
dl Balos - 0 hr poatcold
o) Balos - 2 hr postcold
C) lalos - « hr poatcold
21 Foaalos - 0 hr daring cold
) Fosolos - 2 kr daciag cold
1) Tosalos - » kr daring cold
j| rosalss - 0 hr postcold
k) Foaaloa - 2 kr posteold
11 Foaalos - * kr postcold
Coacsntratlons por 10(1*8) colls
dating and 2* days aftor cold
(olloiing 2000 ag ascorbic acid vith
600 sg aspirin.
12 salo and 8 fosalo aalforslty
stadonts agod 19-23 rr. «ltk sysptoss
oC coaaon cold. Bo sab]octs kad
allorgy sys[toss or kad takoa drags
or *itssin C.
CB09S: TXtaBIISl BLOOD PLtSHU
lIOKOCniS; OBIBBl DISBaSBS; a DOLTS J
SCI; IBBLtBD
a) Pcotclal lovols, placebo gcoap
b) Plocobo groop aftor 1 so
c) Pcotclal loTols, ascorbic acid
gtoap
d| aftor 1 so on 2X500 ag/da}
talaos aro for loacoeytos.
Igrglcal patlonts agos 5a-88 yr sack
•1th prossar* soroa aad Tarioos
clinical allaoats.
lacorbic acid caasod a aoan ndactian
la pcossaro soros of 8»» la 1 so.
coaparod to »2. t% ia control a.
tntllBSl OBJTBD BIBODOB; IDOLTS;
SBXB DISBISBS
BZFEUBCB
Schorak. C.J.
•••Ill, k.
Scott, D.L.
Borgaa. D.B.
1979
Bilson, C.B.B.
Oroono, B.
1978
Taylor. T.T.
Blsssr. s.
Day. B.
Batckor. J.
Dyaock. X.B.
197*
v£>
O
-------
L-lacorbic acid
50-81-7
C6-B8-06
N 176.12. I? 190-192 C
(CORIIIIID)
TISSDI
2419
Blood.
p la Bat
2420
Blood,
plana
_
2421
Blood.
plaaat
ziposDii BOOTH
lagaatlOB
Ingaation
Ingaation
immciL
BBTBOD
IOBBBI
or CUB
al 31
b) 111
c| 32
d| 32
20
„
al 22
b| 12
11KB
a| 0.31-2.1 ag/dl
b) 0.07-0.51 ag/dl
c) 0.10-0.45 ag/dl
d| 0.68-1.42 ag/dl
a| lot givan
b) lot givan
c) lot givan
d) lot givan
a) lot givan
f) lot givan
g) lot givan
kl lot givan
1| tot givaa
j| lot givan
k) lot givan
1) lot givan
a| lot givan
b| lot givan
(HIT
BUI
a| 1.03 ag/dl
b| 0.19 ag/dl
c) 0.22 ag/dl
d| 1.06 ag/dl
a| 1.0 ag/100 al
b| 4.8 ag/100 al
c) 2.7 ag/100 al
d) 1.1 ag/100 al
a| 2.6 ag/100 al
C) 2.6 ag/100 al
g| 1.3 ag/100 al
k| 3.0 ag/100 al
1) 3.1 ag/100 al
j) 1.3 ag/100 al
k) 3.0 ag/100 al
11 3.2 ag/100 al
al 0.71 ag/100 al
bl 0.42 ag/100 al
PlOE)
CIIIUL XirOlBlTXOI
a| Coatcola. agaa 19-55
b| Coatrola, agaa 59-97 (loag-atay
garlatrlca)
c) eeriatric patlanta oaf oca Vitaala
C tkarapy
dl oertatrlc patiaata at 1 g/day, 4
•k
Cata givan (oc placabo groapi.
long-atay patient*, ago* 59-97. la 2
geciatclc kaapltala la Ingle nd. 46
blood-doeoc coatcola, «gaa 19-55.
Clinlcel laprovoaaBta ead night
geisa in tk* Vitaala c gcoap.
TITkBIISi ICE) OIXTBD KIQDOB;
DI3BISBSJ LIOCOCTTBSl 1DOLT3; BLOOD
FU3BI; COBPtUTXVB BTUOaTIOISl
CIRSi IOTIITIOI1L DBPXCXBICXBS;
IDIIinOIlL 01SOID113
e| Belee - 0 kc daring cold
b) Belea - 2 kc daclag cold
c| Belea - 4 kc dating cold
d| Belea - 0 kc poateold
a) Belea - 2 kc poateold
f| Belea - 4 kc poateold
2) Feaalea - 0 kc daring cold
1 Faaalaa - 2 kc daclag cold
1| Feaalea - 4 kc dating cold
j) Feaelea - 0 kc poateold
k| Faeelea - 2 kc poateold
J| Feaelea - 4 kc poateold
Dicing and 24 day* after cold
folloiiag 2000 ag aacorbic acid vitk
600 ag aaplclo.
12 ael* and 8 Ceaale anlveralty
atidanta eged 19-23 yc. aitk ayaptoaa
of cannon cold, lo nbjacta kad
ellecgy ayaptoaa oc kad taken dcaga
or vltiain c.
CIOOS; VITIBIISl BLOOD PLiSBI;
UOKOCTTBSi OlIIBj DISllSBSt » DOLTS;
SII| IBBLIID
a| 19-63 yc of aga
b| 69-B9 yc of eg*
Valnea ace aaeaa edjiatad (or daily
intake. Baana akoa 0.06 ag/100 al
dacliae (oc avecy 10 yr of age (p
-------
l-lscorblc acid
SO-M-7
C6-IB-06
II 176.12. HP 190-192 C
(C01TIIOED)
TISSOI
2*22
Vein*
BXPOSOIB BOOTH
Ing* «t Ion
HHTTICH.
IBT8OD
-
HOI1BBI
or CISBS
20
BlICE
.
•1 lot gi»«n
b) lot gl»«n
c) lot gltan
d) lot gl*an
•) lot given
C) lot gi»«n
g) lot gi*«n
b) lot gi*«n
8EU
a) 6.3 ng/100 al
b) »O.B ig/100 •!
c) 5.0 ig/100 •!
4) 39.6 ig/100 •!
•1 6.3 *g/100 •!
f| «T.6 ig/100 ml
g) *.S ig/100 •!
h) «3.7 (9/100 •!
CIIIM1 IIFOIR1TIOI
•) Dal** - nMing daring cold
b) HalM - « hr daring cold
c) Ulu - c«*tli>g paitcold
d) HnlM - » he portcold
•I F«»l«« - r*«tlng daring oold
() F«>1«« - « he daring cold
g) P«»l«« - covtlng poitcold
h) r«ul«« - • hr (ostcold
Daring and 24 day* aft*r cold
tolloilng 2000 ag ucorblc acid vltb
600 ag aaplrln.
12 ill* and 6 f«ul«
*tad«nt« agad 19-23 yc, ultb
at coaaon cold, lo mbjacti bad
*ll«cgr «7i[to» or bad tak«n drags
or fitaain c.
Tiitiiis; aiooo PLISBI;
1IDKOCITBS: OIIIB; DISBISBS; I BOLTS J
six:
tmmct
lilson. C.(.
Gc*«n«, a.
197B
V£>
-------
l-tkrao-D-g*licto-Octopycuio«U«, Mtkyl 7-cklow-6.7,8-tri4«Mtr-6-{1-««tkyl-»-pcopyl-l-2-pyccoU.4l««c«rboMml«o»-1-tblo-. tcina- «lpk«- (8 CH
l-tkc«o-«lph»-D-g«Ucto-Octopyc»lio»ld«, ••tbyl 7-ckloco-6,7,8-tcld«o«y-6-( tO-««tkyl-»-propyl-2-pyccolldlnyl)c«rbonyl|«»i«oJ-1-tklo-. (23-tcuil- (9 Ct)
18323-M-9
C18-B33-C1-I2-OS-S
It «2*.98. If Bydcocklorfd* kydnt* 1*1-1*3 C
TISSUE
2*23
BlooA.
MEM
...
iiKsnii man
lB9«*tlOB
iiuniciL
IRIOD
Uctobleleglecl
IDIIBI
or cuts
16
HIGH
•1 lot gif«D
b) lot glT«n
c) lot gl»«n
a) lot gl»«n
•) lot glf«n
f) lot gi»»n
INI
t) 2.11 ag/il
b) 0.10 ag/ll
c| O.«1 ng/il
d) 0.73 nq/ml
•) 0.7* ag/il
f) 0.30 ag/»l
oiinit iiratimoi
•) 1.0 kc
b) 6.0 bi
e) 0.33 kr
a) 1.0 kc
•I 6.0 kc
I) t«.0 kc
ll«o glran iltk k»oltn-p«cti»
l«*ltky «aolt« tg»i 23-51 TC (m
29). a*«ng« lit 69 kg.
D100S; tlTIBIOTICSi BLOOO SBIDIi
BICBIOII: IDOLTS
IEFB1EICB
i.s.
D«SMt*. K.k.
Mick. t.D.
OlStnto. l.B.
1978
MD
OJ
-------
licthanna
H39-91-0
La
Itl 139.906, BP 920 C, BP 3»S» C, TP 3230 •• 89 at «00 C, 3120 » Hg at -»«0 C
TISSDE
2»2»
Rale
EXPOSURE tODTB
IHLTTICIL
BBTBOD
Ik
IOHBM
or CISBS
11
tint
0.13-1.11 Pf*
.
9811
o.se PPI
GEIIIIL IITCIBITIOI
Scalp hale
Conora froa 2 flllagu of taika
Indiana in tha taaionas T*ccltocl«s
of fanaiaala.
9IZR; TIIZZDILI; 9BTILS; TMCE
eiBiinsi SODIOB: UOHIBOI; SILICOI;
cnoini; ponssioBi SCIIOIOB;
IITHI09; T»llDI09; CHIOHIO*; GOLD;
BI101IBSE: IBOI; COBILI; IICIEL;
CCPPBR; tIBC; 11SBBIC; SELBtlOR;
BBOUIB; BOCIDIOBi STBOBTIDR; SILTBi:
IITIflOIT; IODI1B: CBSIOB; BlflDI;
HBraiBOR: ciiiDB: smuoB: RBICOIT
IBrtlZICE
Packona. t.K.
T«laaai«, J.I.
Dianas, a.
1977
-
10
vO
-------
7439-92-1
lit 20T.2. » 327.* C, BP 17*0 C, It 1.77 » Bg at 1000 C, 1 •• 89 «t 970 c. 10 >• Bg at 11«0 C
TISSOB
2*25
101 POM
2*26
adreial
gland
2*27
lanlotlc
eiou
2*28
lanlotlc
flail
BXPOSVBB BOOM
Iage«tlon
1BURXCIL
BBTBOD
DltkllOne
DlthlXOne
-
us
BOBBBB
Of C»SBS
*3
«1
1
t
S1BOB
lot given
lot given
lot applicable
lot applicable
(HIT
mi
0.0* ppi nt ¥t
0. 2S ppi »t »t
< 2 «g/dl
90 og/1
PICB)
ainiii IBPOBIHXOB
Idlpoae
saaplea of perlreaal fat froa
aatopalea fcoa the* Cincinnati an*
(1969-1971) of •« nut* aalaa. aged
20-8* yr. 19 traaaatlc dcatto. 6
daatks da* tc droga or carbon
aoaoild*. 21 teathi daa to ••llcal
caana.
HID; IBTtLS; BOMSj IDIF03E TISSOB;
OIIIE; BOSHISi IIIISTXIISS IB1M;
Sill; BUOOII; STOB4CR; Bltlll
1»TBS| TBTIOIO 8HID3I P1OIUT1;
HOOD; IDIIIIL OHID3; LOISSJ SflBBIl
PIICBBUi IIDBBTS; II fit! 10«HJ
IOTOPSIB3; OBIO; BIOkCCVBOIallOB
l«»la d«cE«a*«d »ltk iacc*aiiD9 ag*.
Saaplai fcoa aatopalaa froa th«
Cincinnati acaa (1969-1971) ct «6
•kit* aalu, aged 20-8* TC- 19
tcauatlc d«ata«, C death* A at to
dcags oc cacbon aonoxlde, 21 deatks
dva to Mdlcal caaaea.
HID! HBTILSl BOBBS; iDIPOSB tISSOBi
OBZIB) BOSClBSl IBIBSTXIBSl BBliT;
SIIBj BLIDD8I! STOBICH; B1III;
TISTBS; TBTBOID 011BDS; PBOSUTB;
HOOD; aDIBIIL 8 LI BOS! tOIOSi SPtBBB;
PIBCBBkS; IIDBBTS; 1ITBB; IOBTI:
IOTOPSIBS; OBIO; BIOICCOBOLIIXOB
20 day* befoce dellvetT
tEegnaat 20 re old. In 3rd ttlawtec,
• Itk aandpapac and torch rained
palat fcoa ho«w. 3200 gi C«aale
ton attec 10 >k gestation.
flcthec kad Pb poleoalag 20 4«j«
tefoce delivery. Davelopaent of
lafaat aoraal at 10 ao. bat at 12 ao
cilld »a at 8- 12 ao la cogaltlve
akllle.
BITItSl LBlDi BLOOD; IBBIOTIC PLOIDl
HID POISOBIIOt IBdBTS; tOOlTS;
PJIOS; PHItS
Staple obtalaed daclag aaaloceateals
Benborn feaale and ker 17-jr-old
aotker *ko kad eaten paint chlpa
dnriag tke last aontka of pcagaancr-
Bctker: pain In lover eztrealtlea
(or 3
-------
laad
7«9-92-1
Pt
»t» 201.2, IIP 327.* C. BP 17(0 C. TP 1.77 •• Kg at 1000 C, 1 >• Kg at 9^0 c. 10 •• Rg at 1160 c
(COITIIOED)
Tissue
2»29
tocta
2*30
lorta
2«31
Bladder
2*32
Blood
2*33
Blood
MPOSOBE BOOTS
klkLTTICtL
RETROD
I-raj *p«ctroi
DUhltona
Dithiton*
US
ItJHBEB
or CISBS
5
as
«3
305
««
FUGB
lot giTan
lot glren
lot glna
0 . 2- 5. 3 uoln/1
>60 09/41
(IIR
SB»»
8.38 ppi dry vt
1.65 ppi »et «t
0.09 ppi »«t »t
lot glna
lot glToft
PUI)
GtltBIL IIPOII1TIOI
3 iaipl*> per ca«». 2 analyies p*c
aaipl*.
1974 utoplUa of 10 Flu Indian*, a
Papago, aol a Crack Indian.
(OHSSIOBi CtlCXOB: HOB; COPFBB;
IIIC; BOBIDIOR; BICKBl; LBlDi BBTkLS;
IBiCI BLBRBBTS; LUES; SPLBE1; tOBTt;
HOISTS; ftOUOSE TISSOEj P1ICBE1S;
BUSOBEBEBT BRBODS: IHtOFSIlS
Oocall latala lnc»ai 2 ppi a«aociat«d «itb ni*t*
atbaroaclaro«l«.
3aapi*« (coi aatopal** froi th«
Cincinnati ac«a (1969-1971) cf «6
•kit* aal««, ag«d 20-6* jr. 19
tciniatlc d«ith>, 6 daathl dm to
d»9« oc carton aonoxid*, 21 deaths
dM to ••dieil caaaaa.
l»D| BBtlLSl BOIES; IDIFOSE TISSUE;
OIIIE; BOSCLISj IB1BSTXBES; BE»BIJ
SEII; BUDOEB; STOBiOl: BB1II:
1ISTES; TBTBOIO OL1BDS; F10SUTI;
81000; 1DBIBU OL1BDS; LOBOSi SFLBEBi
(IBCISkS; BIDBBTS; HTBBj iOn»;
•OTOPsiBS: OHIO: BxoiccoBaiknoE
Saiplaa froa aotopaim Croi the
Cincinnati ana (19(9-1971) cf «6
•bit* ••!••. agad 20-8 » jr. 19
tiauaatlc daatha, « death* doa to
dt«9« oc cacbon aonoxida. 21 d«ath«
dM to Mdlcil caaMa.
tl»D; BBTILS; BOBB9; tDXVOSI TISSOB;
OBIBE: BOSCltS: IITBSTIIES) (EIIT;
SHI! BL10DBI; STOI1CI; BBIXB:
1UTBS: TBTIOID OLtlDS; FBOSUTB;
tlOOO; 1DBBBU OH IDS; LOIOSJ SFLBBI;
PIICIEtS; (IDBBTS; LITIBl «OIT»;
unopsiBS; OBIO; Bioiccraoitnoi
Canlah aan ocapitloMlly «s|OMd to
n.
FBOTOFOBFBTBIBS; IttO; OCCOFITZOBIL
BlItBOS; BHSUBBBBIT BBTBODS; BLOOD;
BIBOOIOBIBS; BET1BOUTES; OIBBIBK]
IBMTS
Chlldcia «lth anaiia. 38 of 6«
haaogloblaa <11 g/41, 3 of 3 t had
nocaal aacaa iron l«ral*.
PatUnU it IllCHka* Chlldcan'a
Boapital.
IBlDl IBOBl BtEOCLCBIBS; FBOTBIBS;
BtTtLS; BIOOD; BLOOD SBBDBl UtD
fOISOIIIB; HBTIL FOISOHB9; CBILCBBB;
II3COISII
lEfEBEICE
Bangalaon, I.r.
Bill, fl.l.
Blelion. U.K.
Zatoagh, D.J.
Chrl*t«n*«n, J.J.
Ixatt, B. a.
Bicbarda, D.O.
1979
Groaa, s. B.
FfltMC, E.I.
Toagoc, D.W.
Kahoa, «.».
1975
Ocoaa, s. B.
FfltMC, B.I.
T«ag«c, D.B.
Kaho«, 1.1.
1975
Crudjcan, F.
1979
Stold, F.D.
197*
1
VO
-------
lead
7«39-92-1
Itl 207.2, IF 327.* C. IP 17W C. TP 1.77 SB Hg at 1000 C, 1 •• Bg «t 970 C. 10 mm eg at 1160 C
(COITIIBEO)
TXSSDI
2*3*
B1004
2«3S
Blood
2*36
Blood
2137
Blood
^^_^
BKOSOIB IOOM
Iog*«tloi.
&IUTTXC&L
HBTHOD
us
Colorlaetry
US
IOBBII
OF CaSBS
*l 7»
b) 73
2B
al 57
b) 2«
c| 52
4) 23
a) 32
b) 70
cl 1«
SIIOB
•) 13.1-20.2 ag *
b» 16.3-22.* ag S
Bug* of Beans
-
16-51 ug/41
a) lot glren
b) lot given
c) lot given
d) lot given
a) Cot given
b) lot given
c) lot given
(IEXT
DM!
•1 lot gives
b) lot given
26. g of
Oiaha. IB
lltUSi IBIO| BMWOi DOSTl SOILS!
CIZLDIBIJ HMlSUt 1X1 PO11RIOI;
1ITB1 POttOtlOl
Ircn «ork«r» •xpoax] to l«ad oilda.
lor* data available.
Ircn wrkvrs repairing an «l«*attd
callcoad natvork IB ••« York City.
lUDt SXICl ntlLSl TlaCB BlBIBMSt
PIOTBXIS; BlOOOt OCCOPaTZOItl
RIZlIDS; »• TOM
a) Bipond iMltvr «ork*ra
t| Saaltar «ork«r controla
c| UpOMd ala«ra
d) llnor control*
Icrkara In lead malting plant and
laad alnora IB Brazil.
laad polaonlng aynptoaa in •czpomd'
aad 'control1 groapa. Poaalbla
laaklng of ayaptoaa by paraaitoala in
lajorlty of botk gronpa.
•Iipoaad" aad 'controla* kad
••aoglobin and haaatocrlt !•«•!•
t«lo« thoa* conaidarwl noraal IB
d«««lop«d arm*.
HID; IBTaLSt BtOOD) IIDDSIBIll
POLIOTTOI; BIIII6; SHBLWISJ BBMIt)
HOOSttlH. DISB1SBSS RBTaL PCISOIIIO;
IIFBCTIOI
a) 721 currently or pra'ioaaly la
•poor* hooalng
b| BBS carrantly or previously in
•poor9 boaslng
c) 9l( cnrrantly or prarlonaly In
"Foor" honalng
I In tar Latela
•Poor" koBalngi peeling paint and/or
t token planter
llm In blood Pb o( 10 ag/100 al or
greater froa elnter to anaaer
predictable In cblldrea nnder 3 rr
and/or tboae expoaed to paint or
planter. Otker data and statistics
available.
701 Black. 29* Spanisb-aserlcan. 73t
(roa faaillea on welfare
Iges 10 no - 12 yr.
101: CBILDIBI; BLOOD; LUOi IBTUS;
IDTIITIOItt DISOIDIIS; PIC1; PtIITSi
III TOIK
IBniBICB
Ingle, C.4.
BeXBUce, l.s.
Colocci, a.T.
197a
risckbelB, a.
tills, B.
1977
lendes, B.
1977
BcCusker, J.
1979
10
SO
-------
74-9-92-1
Pb
»t» 207.2, HP 327.1 C, BP 17*0 C. TP 1.77 la 89 at 1000 C, 1 Be Rg It 970 C, 10 II Hg «t 1160 C
(COITIIOID)
TISSUE
2438
Blood
2439
Hood
24*0
Blood
2»«1
Blood
Eirosnis ROOTS
Ingest ion
-
UllTTIClt
HKTROD
US
us
us
us
IOB8ER
OF C»SBS
•1 IS
bl 16
C| 12
661
«) 37
b) It
e) 92
a) 30
b| 32
O 20
HIGB
a) 12-29 U7/100 il
b) 30-49 a9/100 si
c) 50-67 uq/100 il
12-73 09/100 •!
a) 19.7-41.1 09/100 ml
b) 14.9-27.6 09/100 el
c) 4.7-15.6 09/100 al
-
a) 5.0-10.2 09/dl
b) 9.0-17.0 og/dl
c) 14.5-36.5 09/dl
RB1B
a) lot given
b| lot given
c) fat given
lot given
4) 30.1 09/100 ol
b) 21.1 og/100 al
cl 9.4 09/100 11
•1 B.3 09/dl
b) 12.8 09/dl
e) 26.5 09/41
(IIR P»BI)
GIIBUL IIFOIBITIOI
I) 56t exhibited pin
b) 94* exhibited pica
c) 93* exhibited plc4
Inverse correlation between CM Intake
»d blood rb.
43 children, 1-6 yr old froa section
ol Rilvaakee, ilaeonsln containing
951 of tie Pb polaonlna caava. 35
tlacka, 4 Be i lean laerlcana, 3
Caacailaaa, 1 Peerto llcao. Rany
aoaMholda aid paint tilth alga rb.
lelltlTe decreara in height
;erc«ntlle nith increasing blood Pb.
Ion* of »ebject» treated for Pb
toilcitf.
CICa; IE1D POISOIIIO; PallTS;
iniBiTioiai DBFicinciss: TBICS
(IBBRRSI lltC: BlOOOt DIRS;
CBILDISI; IISCOISII; HBT1LS
..
Children, oat pat lent* In Rontreal,
Canada, aoat 3-7 yr old.
I1TILS; tB»D; BLOOD; CRILDIBI: C1I1DI
a| Children at school < 1 ka froa
«Mltar
b) Children at school 2.5 ka free.
aaelter
c) Children at school in roral
nonlndastrlallsed area.
Belgian children, ages 10-15 jr.
BI1U.S: IBaD) BLOODl SHRtTBBS;
CHLOIBI; IDOLBSCIRS; BELellH!
iiDOsraikt tills; IUIIL iiu:
a) loral popilatioa, alnlaal eiposore
t) Orban dvellsrs, BO occopational
eipoaare
cl ladlvldoals. aoderate occupational
eiposare
10 (aalliea (parents »lth 1 child)
froa, village north of Tokro, 10
taailies (parents «lth 1-2 children)
frea orbac Tokyo, 20 sale
lena-aaaa(act«rera in Tokyo.
10 clinical evidence of Pb poisoning.
gntLS; IBID; BLOOD! IUD POXSOtTNS
IIITRIOCIT1S; BISTIIS! *DOIT3|
CBUDIBIi JIMI: OCCDP1TIOI4I
lltllDSt lORaL llltS | 018 11 UB1S
RBFBIEICZ
Johnson* I.e.
Tenota, K.
1979
Behkeri. K.l.
loaanoKskl, I.
Ssallbone, B.
1976
Boels, fl.
Backet, J.
Laoverrs. I.
Bnbereont, c.
Braaax, s.
Claeys-Thoceau, P.
Lafontaine, i.
Orerschelde. J.T.
1976
lada, 0.
Takeo, I.
lano, T.
Tetso, 0.
lagaaashl, I.
Sekl. R.
1976
oo
-------
lead
7*39-92-1
tb
It! 207.2. H 327.* C. BP 17*0 C, TP 1.T7 •• Ig at 1000 C. 1 • • 89 at 970 C. 10 •• (9 at 1160 C
(COMIIMD)
TISSOI
21*2
•load
21*3
Blood
2»*»
Blood
21*5
Blood
.-- —
Bxposon torn
—
1IILYTICIL
IBTBOD
US
US
— ioaiBl
or CISBS
1
•I S7
b) 51
C) »S
d| «3
•1 29
f| 19
91 17
h| SI
II 37
11 "
k) 111
1) 36
•1 S
ol 7
o| SI
P) 23
9.1 11
C| 3
IB
IIIOE
lot applcable
•) lot given
b) lot given
e) lot given
d) lot given
•1 71-191 ppb
f) 97-2*9 ppb
9) 123-327 ppb
h| 58-383 ppb
1) «S-262 ppb
j| 1*6-772 ppb
k) 101-900 ppb
1) lot 0.1m
•) lot given
n) lot given
o) lot given
p) lot given
g.) lot given
r) lot given
33-66 og/100 il
(IIR
•111
33 19/100 9
•1 138 ppb
b) 112 ppb
c| 130 ppb
dl 1*3 ppb
•1 119 ppb
fl 15S ppta
g) 196 ppb
h| 1*7 ppb
1) 119 ppb
j| lot given
k) lot given
1| 127 ppb
•I 138 ppb
n) 163 ppb
ol 128 ppb
p| 138 ppb
g) 1S8 ppb
c| 190 ppb
Rot given
P»OB|
eiiiiti xiroiiiTZOi
ligut 1977
•9-yr-old ckealcal plut corker (1966
to 1975) exposed to CdS. Mlnld*
dut, «OM lth poulbl*
clccbotlc pattaco aid calclflad
gcaialoaa OB l*ft lang.
•RUS; CIDIIOI) LHDI SBLEIIOII
UK; BLOOD; on n i nonisi BBTH
poisoniai occopMioiki Btsimai
units
a) Bal<>
t| r2 ka froa Mcoodarr Pb
< Ml tar and ag*d 2-3 r'
)| lorkan. car Cactorr
k) tockaca. aacoadarr Pb sMlt«r
1) lonaaoklng aalaa
a) lala aaokara: 1-9 clgar»tta«/Say
B| Bal« aaokara: 10-19 clgartttaa/day
o| naaaoklBg taaalaa
p| Taaala aaokara: 1-9 clgarattaa/day
91 Faaala aaokara
10-19 clgarattaa/day
r| Faaala aaokara: 20 or aora
cigarettea/day
Citch aobjaeta agad 2 ao or elder.
BIT1LS; CtDBIOR; CCPPBIi ItO!) LUD;
IIIOllBSIl tlICi BIOOOl BLOOt 5NOBi
3BOIII8; 01 H COITItCBPTITES :
IIDOSTIIBSl SIBLTBU: aDOLTS:
CRiioiBii an-. «rram»iDs
i«»ia«
BIOIISIOBt LHO; tlKI BBTllJ; T»»CI
I1I8IITS; OIIIKIIS (iTn; BLOOD;
BIOOD SEIOJ; ntlt; BOIIS; OIIT1D
IIIODOB; ClllOk; OIITBD STkTIS;
TIllkID
Children agea 13-67 ao. Taloi«
correlated alth erytorocita
protoporphrrln bat not vita ariaary
111. urinary Pb, or chela tab la Pb.
Children In prospective screening
[rograa at J.F. Kennedy Institute In
1972.
tllD; LBhD POISOIIIO; BBTILS; 1RIL
tCISOHM; CORP1IITITI BtHgiTIOIS;
BlintlDi BBlSOlBHtIT HBTBODS
UFItnCB
Lamer, s.
Bong, C.D.
Boslan. I.e.
1979
Ilelhnla, ».l.
del Caatllho, P.
Berber, l.r.l.
llbowo, i.t.B.
1978
Sharrett. I.E.
1977
Chlsoln, J.J., Jr.
Barrett, I.B.
aarrlaon. H.T.
1975
VO
VO
-------
lead
7439-92-1
Pt
in 201.2. HP 327.« C, BP 1740 c. fP 1.77 an Hg at 1000 C, 1 an Hg at 970 c, 10 ee Rg at 1160 c
(COITIIOED)
TISSl)'
2446
Blood
2«*7
Blood
24*8
Blood
EIPOSOIE BOOT!
miTTIClL
HETBOD
•DHBBB
or ctSES
at 172
bl 199
c) 191
d) 163
•) 194
(I 89
I) 53
b| 45
» 22
b| 37
BUG!
a) lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
e) lot applicable
f) lot applicable
a) 10-78 09/100 el
b) lot given
a) 0.5-1.3 iiBol/1
b) 0.6-4.2 oeol/1
a| 98.8X
b) 75«
c) 28*
d| 26 »
e) 12*
f) 1-2*
•I 26 » ot - 11
99/100 ll
b) 10 » or - 2 ng/100
el
a) 0.8 ieol/1
b) 2.2 owl/1
Rediau.
BEFEHEICE
a) 0-1.6 ke
bl 1.6-4.0 ke
c) «. 0-10.0 ke
d| 10.0-24.0 ke
e) 24.0-12.0 ke
() Control (72 ke)
velaas ace 1 iltk 40 og/dl Pt or
higher bj dletance froe eeelter.
Blood Cd, Sb, and km not correlated
•1th dletance froe aeelter.
Children lltlag near a prleacr lead
•letter, and control!, all 1-9 rr of
lo (rank peoroloqlc abnorealltles in
202 atodied.
Tree erfthrocrtc protoporphyrin
correlated and keeatocrlt neg«tlT«ly
correlated «ith blood lead, lo
pathologic nerve condictlon
telocltie*.
1110; IDtIO; CHI10III; CORHEITITE
EtllOITIOISi BLOOD; II IB II;
HOIOtOBIC IIITFBSTmOIS
e) Occipationallr expoeed to Pb
b) Controls
log errthrocjte tLl-dehydrataee
inverMlf correlated elth blcod Pb.
leg erythrocyte Prrtoporpkycln
dlnctlr related tc blood Pb. lo
difference eean arlnarr IL>. expoeed
tecaee control*.
•crkere occepatioaally expoeed to
lead in a pol»»infl chloride factory
for 3-18 yr. Healthy onexpoeed
control*.
ItlO; JlPtl; OCCOPITIOIlt ItUIDS;
CCBPHITITE CVIL01TIOIS; BLOOD;
ItMtS
a) Control*, no kncen occopational
•ipoeare
t| Occapational expoiare froi 1 eonth
to K *r.
Centrole-, eged 18-44 yr, enployed in
•ill proceulng edible oil* tnd fttty
aclde. ItsoMd factory >ork«ra, aged
18-50 yr, eaployed In batter)
factory, radiator repair eho[,
Itad-rolliig eill, cable
•aiotactering.
Faychological te*ta of expoeed group:
dlfficolty la traneterrlng eaterial
(roe *hort-tern to long; tare eeeory,
depr«««ed peychonotor epeed, eoee
lapalreent of coon it ire fanctlou.
IRUSi LBID; BLOOD] IUI]
CCCOPITIOIII ItlUHi COBfttlTXTI
ETiiaiTioist ixpnnntai PUCMLOSTI
ICOLTS; Dllltll
(MR PUB)
Landrlgan, P.J.
Baker, B.L.. Jr.
Peldnan, I.e.
Cox, D.B.
Eden, «.».
Orenstoin, 1.1.
lather, J.i.
Tankel. l.J.
von Linden,
1976
I.R.
Toeokeni. K.
Ogata. 8.
1976
OJ
o
o
Orandjean, P.
Irnvlg, I.
Beckeana, J«
1978
-------
Lead
7*39-92-1
(b
Itl 20T.2. If 327.4 C. BF 17*0 C, Y» 1.77 » 89 at 1000 C, 1 as Rg at 970 C, 10 mm Bg at 1160 C
(COITIIOID)
TI3S0B
2«*9
Blood
2*50
Blood
2*51
Blood
2*52
Blood
BIPOSOBB soon
Ingest ion
Ingest Ion
IngSStlOn
1B1LTHCIL
BBTBOB
US
.
•OBBB1
OP C1SBS
7
1
1
1
UBOB
71-138 og/100 •!
_
lot applicable
•) Bot applicable
b) Bot applicable
c) Bot applicable
d) Bot applicable
96-120 og/100 il
(BBR
mi
99.7 og/100 ol
SO og/dl
•I 70 09/100 al
b) 11* e.g/100 al
c) 79 eg/100 al
d| 72 09/100 19
106 09/100 al
PtOB)
flBBBMl IBPOBBMXOB
111 had clinical «lgna of Pb
poisoning.
in
laployeee of skip-necking yard i
Coteborg, Steden, (or 6 «k-20 yc,
•g»d 26-66 ir.
•elgkt loaa, abdoniaal pain,
constipation and/or dlarrkea.
tatlgoe. craapa. veniting
BBTU.S; LSIDS BlOODt DBIBI; 1DDUS;
CCCOPlTIOBal BaStBCSi C»3B BBTOBIBS;
SBBDBB
<6 no aid infant adnittad to konpltnl
IB BT City.
salnras, llatleuDen, poor feeding,
focal aloiing and car* nkacp «a*e« in
left poateco-latecal area an •bom by
•lectroeacephalograa, iccitatllltj
BMOpkillc stippling of c«d tlood
calls. ele»ated free erytarocrte
pictopotphycla
BR1LS; IBaDl B100D; IBFaBTS; BBI
IOBK
at Tin* of adnisslon
b) 20 eoataa aftac adnlssloa
c) 28 nontks after adnission
d) 36 nontbn after adnlssioa
Clack nonan aged *6 yr fron Jersey
City. BJ
Cilse rate of 106/nin. grade XI/TI
•idsystolic e)ectlOD nornor, grand
••1 sslinre
insaia. Encaphalopathy, lead
nacktopathi. *ltillgo and
hyperplgaentatlon of gans, pals
conjectlTae, ateraa enlarged «lth
fibronyoaata.
tUDj HOI; BBTILSl BLOOD; BIOOD
SIIOB; LIIO POISOIIIOI MBBZI; It»
JBBSET; BBOBOLOOIC BlimStaHOIS;
BIlfODS ST3TSB DZSUSBS; OBXBB
Fatlent aged 2* living in Britain had
purchased aphrodisiacs fron
Bangladesh.
Constipation, prscordial pnin,
generalized pain, colicky loin pain,
nanssa, nnd vonltlng
intestinal lleos. alderoblastic
tceala
HaOf BBTkU; IE1D POISOBIIG; OBITSD
IIBODOBl BIOOD; OBIBB; BLOOD SB1DB
craner, K.
Boyer, B.I.
Jagenborg, B.
lilsoa. B.B.
197*
Sitars, t.L.
197S
fedeen, B..P.
Sallilt. D.I.
Batanan, T.
Bogden, J.D.
1978
U)
O
Brearley. H.L.
For«7the, a.B.
1978
-------
Isad
7*39-92-1
fb
ttl 207.2, BP 327.« C, BP 17*0 C. TP 1.77 •• 19 It 1000 0, 1 •• 89 at «->0 C. 10 •• Rg at 1160 C
(COITI1DBDI
TISSUE
2«S3
Blood
2aS»
Blood
IIPO30RB BOOTS
Inkalatlon
IIILTTICH.
HETBOD
. _ ..
MS
1ST
BOBBER
or CISBS
a) 1
b| 1
C| W
20
MICE
a) 36-118 ng/91
b) «0-177 ng/dl
c) OO-50 ag/dl
7 0-1 «0 09/100 si
mat
a) lot given
b) lot given
c) Rot given
lot given
OBII11L IIFOBBITIOI
a) Patient 1 ad sit ted to hoscltal 3
tlses In 11 souths. Baxlsua value
and death follosed thlcd adnlsslon
b) tatlsnt 2 adsltted to kosfltal
nice
c) Canadian Indian cklldcen
Patients 1 and 2. U and 16 yc old
sales, cespectlvely, with history of
fcegaeat gasoline sniffing, tros
Shauttasa Indian teservatloi in
BoctkeastecB Manitoba, Canada.
Children aged 9-17 yc fcos Little
Brand lapids Indian resecvation in
Instecn Bsnltoba, Canada, with
history of ssltiple sajor social
(cobles*.
Oisorientatlon, trenors. ataxlc gait,
ballnclnntions, sleeplesssssa,
hypotension, apnea, fever, cardiac
arrest
Basophillc stippling of BBC'S
BITILSI LElDl S1SOLIIE; LEID OBOIIIC
COBfOOIDS: tUD COBPOOBDS; BLOOD;
BI«L POISOIIIS; LUO POISOIIIB; DBOO
HOSE; C1SE BISTOBIBS; IDOLESCBRS;
CII1DIBI; CtMDl
Bisor nescoleglcal and kistological
atnorsalltles noted kad little
relation to blood lead levels.
•crkers in lead sneltlng sad refining
plant i> Dennark.
1 slth history of chronic esfosore
had colic and high blood lead, and
lo« hesoglobin, piss signs of lead
neuropathy, sencologlcal
atnorsalitiss belo* point of
nesropathy, foend in 7 of 20 sen.
Slight Increase in fibers clth
paranodal reayelinatioa. Sons
isternodes of snail dlsseter.
possibly sacking onset of prlnary
denyelinntlon or of axonal damage.
HOOD) DE1RIK; LB»; BR1LS;
iinoLooic Miirisunoisi
GCCOPtTIOIIL HSUDSt SRILTIIS
IBTMEICB
BoeckX, B.L.
POStl, B.
CoodlB, F.J.
1977
Bachthal. P.
Behse, I.
1979
o
to
(IBXT PtGS)
-------
7«3t-*2-1
Pb
Itl 207.2, n 327.« C, BP 17W C, »P 1.77 » Bg at 1000 C. 1 •• Bg at 970 C. 10 •• Bg at 1160 C
(COITIBOID)
TxssoE
2»5S
Blood
2*56
Blood
2«57
Blood
IZPOSON SOOTS
Inhalation
ininxciL
•moo
us
Dltkiton*
IOIBBI
OF CASES
It Bot
given
b) lot
given
O Bot
given
41 »0-6«
•) 23
n 23
21S
»3
itiai
•I 53-7« ag/dl
b) ««-77 ag/dl
c) 29-»3 gg/dl
4) < «0-87 ng/41
•) le»* tku 20 to > or -
60 09/41
f) !••• than 20 to > or -
60 ag/41
«7-*71 «g/dl
Bot given
(IBIT
BUB
•I 60 ag/91
b) 56 ag/dl
c) 35 ig/ai
4) Bot gi*oa
•I 31.9 »»/41
f| «1.2 ig/al
BOt jlTOB
0.21 ppl ««t ¥t
PISE)
G1IIB11 XBPOBBUIOB
•) Firing rug* 1 lutnctori
b) Firing r»o» 2 las^ractoci
c| Firing rug* 3 ln«tr«ctor«
4| rir«>cu l*«tr«ctor*
•t Flr««ri» lutnctor*, tft«r
oatdoor training period
(I flr*«ru lut»ctor>, after Indoor
training parlod
Bnploy*** of Ian Mforcannt agencies
In ••• York, n*u ag* 10.3 ji, n*an
diratlon of *nplojtMnt 6.6 yr.
Baadaca*, dlixinvu. fatlga*.
aaakn«ca. n«cro«a«aa.
aiparlrrltabllltT. and *l**p
dlMarbane**. lorn* of app*tlt*,
••Igkt loia, abdoalaal dlacoafort and
pain.
tIU| OCCDPtnOBal. BtSUDS; (BTtLS;
CEITBIL BBIVODS SIStOT DISUSIS;
GISTBOIBTIS1IB1L STSTM; BIOCDi
PBCTOPOBPBTBIBS: BIB TOBf
larala datactad b*t***n 1966 and
1972. Bo correlation. In *7 caeaa
taatad 2-8 jr later, batnen Pb
polaonlng and certain nental trait*.
patient* detected taroagk *CBMnlng
cf blgk rl*k nalgkbarkood* vkan 1*-72
ao of age (aeao-30 no) Sibling
control*.
18 patient* «ltk !***!• above 127
•g/dl **f fared fro* «o*ltl*g.
dro**la***. lrrltatlU.tr or ataxla.
BBTILSt HID; LMD POISOBIBBt
CCBPiBITXVI ZttLOHIOBSl IkHBOMGIC
BlBXFBSTkTIOBS; CBUDIBB) XBUBTSt
tlOOO; XllIBOIS
Soaa decreaaa in aaan level* vitb
lncr***lng age.
Suple* fro* antop*!** fro* tba
Cincinnati area (1969-1971) cf «6
•kite Mlea. aged 20-8 « jr. 19
trauatlc death*. 6 deatk* do* to
drng* or carbon aoaoxida. 21 death*
d«* to nedical can***.
LIID; BBTtlS) BOBKSs tDIPOSS TXSSOB;
OIIIB; BOSCllSi XBTISTIBBS: RIBT;
SHI! BLlDDIBt STOBtCB; BlaXB;
TISTBSS TBTBOXD SLMDSi PBOSUTB;
tlOODt tOBBBll OllBDSi LOIOSJ SPLEBI;
PIBCBBkSs IIOIBIS; LITIB; »0lr»;
lOTOPSXBSi oaio; BIOICCDBOUTIOI
BaraaBHCII
Fl*ckbeln. t.
Bice. C.
sarkosl. I.
Ron, s.a.
Pectrocol, B.
Selikoff. x.J.
1979
Sack*. B.I.
(rail, T.
Bccanghraa, D.I.
BOMBteld, X.I.
Toang**itk. B.
6ro*e, 0.
Lasar, B.S.
Bovar, I.
O'Connell. L.
Bay*OB. B.
1978
Groaa. S.8.
Pfitsar. 1.1.
Teager, D.(.
Keko*. B.I.
197*
u>
O
-------
lead
7*39-92-1
Pb
lt» 207.2. BP 327.11 C, BP 1710 C, TP 1.77 >• flg at 1000 C, 1 » Hg at 970 C. 10 •• Rg at 1160 C
(COBTIIOBD)
TISSOB
2*53
Blood
2«S9
Blood
2«60
Blood
2M1
Blood
EIPOSOJ! BOOTS
.. _.
Ingest ion
Ingest ion
U1LTTICIL
BBTBOD
US
R0RBBB
OF CISBS
•1 1
bl 1
C) 56
d| 56
133
2
-, -,, -
9B
B1IGB
a) lot applicable
b) lot applicable
c) 10-30 ng/dl
d) 10-32 ug/dl
2.5-52.5 ug/100 el
a) lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
e) lot applicable
f) 21-«9 ng/dl
> 0.5 og/g
(HIT
mi
«l 35 ag/dl
b) 13 ag/dl
c) 17.3 ag/dl
a) 17.2 og/dl
12.* ug/100 il
a) 86 ug/dl
b) *1 ug/dl
c) 26 ug/dl
d) 60 ug/dl
e) 72 ag/dl
f) lot given
lot gives
raoB)
GEItBIL IBPOIHlTXOI
a) 6-io-old exposed to nevsptlnt
log-burning
b) Rother of 6-io-ol4
c) Control infants 0-6 so of age
d) Control sothers
loos dost lead levels related to
nensprlnt log-burning.
6-ao-old breast-fed baby and a other.
COBtrol infants and nothers in the
saae connnnity.
Rarked elevation in erythrocyte
prophyrln.
HID; LEID POISOIIIG; WE» TOM;
HOOD; COHFtllTITB EVltOlTIOIS;
BITUS; IBTU POISCBIIG
lo occupational exposure. City
vorkers had significantly elevated
(blood Pb. other correlation! are
presented.
Bealthy donors of transfusion blood
during July-Sopteeber of 197*.
HID; BETtLS; BLOOD; IDSTIaLUl
COIPlllTITF. BValOlTIOIS
•I Bother before chelatlon tbarapy
b) Bother after 2 days chelatlos
thernpy
c) Rother at discharge, aftec
delivery
d) Cord blood
e| Infant at 1* days
fl Infant range for 3- 18 so vita 2
periods of chelatlon therapy
•••born fesale and her 17-yr-old
•other iho had eaten paint chips
during the last nontax of pregnancy
Bather: pain in lover extraaitles
for 3 vk, diagnosis of lead
poisoning.
Bother: sose basophillc stippling of
BRCS
Infant: bone nnd IBC signs cf
elevated lead.
HID; BRIaLS; III TOM; BBTll
IOISOIIIG; LI1D POISOIIM; PIBOmCT;
IIFalTS; IffBOtl; 1BIIOTIC PUtD;
BtOOD; PICII gtBXlICU COID
levels la 98 of 705 children
surveyed.
Children in a rnn-Aon area cf
Boston.
lead toiicity noted. Central nervous
systess effects: hyperactlvity,
behavior probleas, leaning
disabilities.
HID; IBTIlSt CBTtDBll; BLOOC;
uoioioaic iiiiFisiiTiois;
RIOlCCDIOllTIOIt DIBU UB13:
BBB1VIOI DISOIDBIS; H1SSICBOSHTTS
UFBIBICE
•
Perkins, I.e.
Oskl, F.I.
1976
Rencel, S.J.
Thorp, R.R.
1976
Tispo. I.E.
anin, J.s.
Casallno, B.B.
Tuceoglu, I.R.
1979
Pueschel, s.R.
co
o
-------
imd
7*39-92-1
n
Itl 20T.2, BP 327.* C. BF 17*0 C. YP 1.77 •• 89 at 1000 C, 1 •• Hg at 970 C. 10 » Bg at 1169 C
(COITIIOED)
TISSUE
2*62
Blood
2163
Blood
2*6*
Blood
2*65
Blood
BZFOSBU BOOtB
Deraal
. —
iMLTTiciL
HMOD
US
us
Dithizone
lOiBEB
OF C1SBS
•1 3
b) 36
C) 22
d) 1
» 10
bl 9
•1 23
b) »2
c) 35
d) 23
BifCl
•I 20-3* ag/100 ml
b) «3-87 ao/100 ml
c) «B-108 ag/100 el
d) lot applicable
a) 10-25 09/100 al
b) 11-7« ag/100 al
a) lot given
b) lot given
c) lot given
d) lot given
(IEIT
BBll
a) 28.6 ag/100 al
b) 57.1 ag/100 al
c) 7B.2 ag/100 al
d) 205.2 09/100 al
a) 16.0 ag/100 al
b) 28.22 ag/100 al
a) 7».S « or - 26
ag/100 il
b) 52.6 » or - 21
09/100 al
c) «1.0 » or - 12
ag/100 al
d) 23.0 » oc - 1»
ag/100 al
pnsi
ailllal IirOBBHIOB
a) Idalnistcatora, laboratory.
technician |alr levels. 11.9-17.0
««/•»
b) forkeca: •alatananco, load lag,
kitcben. battery assesbling 1
sealing, gctd sseltiag f canting.
breaking C dcflng of plat««.
il>c*llaa«o» (air !•*•!•. 23-299
ag/«3J
c| lockers: drying, breaking «
Matching platei. Conation, nixing.
[ocder preparation, oven Molting.
pavtlng S drflng. oxide fabrlcatioa
(air larala. 266-1315 *9/a3)
d) lorker doing odd joba, ooaa
eTenlage epant in (actorr.
Battery factory corker* Bean age 37.*
(range 19-65), aeaa •ealorlty 7.0 yr
(range 1 ao-26 yr) .
Fatigae, neadacte, abdoainal craapc.
lace at appetite, or aauea reported
by 13/26 vorkera tilth blood (b tetela
of 20-59 ag/100 cc and by 23/35
aorkers vita levela of 60* ag/100 cc.
S1TILS; LB1D; BLOOD; BIOICCOBOLITZOI;
Rtttl POISOIIIG; OCCOTlTIOHl
HII1IDS; IIOOST1I11 tTBOSmiBSi
ISIkBL
a) lon-expoaed
E| ixpoaed
Blfference batoean gcoopa *aa
•ignlflcant.
Eaployeea of I.T. SIDBU ateel plant
in Ghent, Belgian.
imU; IBID; BLOOD; OCCOTHIOIaL
BIIHDS; BE10IOB
a) Fb-poiaonad norkera
b) forkera tilth aodatataly increased
Pb absorption
c) lockers aith slightly Incteased Fb
absorption
d) lorkers alth physiologic tb
acaorptlon, polluted enTironnant
Croaps established on the basis of
•oikers1 cosplaints, clinical
exaalnation and toxicologies 1 tests.
lockets eaployed 1-23 yr in •
langarlan storage tattery plant.
lone of the cases of chronic Fb
polsoalag investigated had severe
ayaptoas of colic cc encepkalopathy.
IIT1LS; LEIDi BLOOD; OIIIB;
OCCOFHtOIlL RaXllBS; COBFaBITITB
EtlLOlTIOIS; SBIi BOMalT
•aviev
ItTIII: LttD; HETIL FOISOIIIC;
CIILDIII; IIDOSTBItL BBZSSIOES;
FURS; lOTBITIOIlI. DISOIDBBS; IOE;
BtTlLS; BLOOD
urauicB
Blchter, S.D.
Taffe, I.
Sneaer, I.
1979
van Fategbas, T.B.
deTos, B.
197*
Lancranjan, I.
Fopescn, B.I.
OaTanescn, 0.
Klepsck, I.
Serbanesca, B.
1975
Hccabe, E.B.
1979
CO
o
-------
laid
7*39-92-1
n
ttl 207.2. BP 327.» C, IP 17«0 C, »P 1.77 •• Rg at 1000 C. 1 •• Rg at 970 C, 10 » Hg «t 1160 C
(COITIIDED)
TISSUE
2*66
Blood
2*67
Blood
2*68
Blood
2*69
Blood
2*70
Blood
EXPOSURE BOOTE
IIILTTIC1I
siTBOD
us
us
us
IORBEI
or OSES
10
12.000
•) 8*
b) 130
•1 '3
b) 36
•) 39
b| 20
cj 100
d) 22
IIIGE
29-98 aq/100 ml
a) lot given
b) lot given
e) lot given
*) lot given
b) lot given
uu
•I 0-68. S 09/100 ol
b| 0-7.5 09/100 *1
•I 36-89 09/100 .1
b) lot givan
e) lot given
d| 2»-82 09/100 •!
(HIT
HEtl
50.57 ag/100 il
*) >60 09/100 il
b) 135 ag/100 il
c| 86 ag/100 •!
I) 0.91 » or - 0.77
«g/g
b) O.SB • or - 0.93
ag/g
•I 18.* » or - 12.9
19/100 ol
b) «.0 ag/100 •!
•1 62.1 » or - 13.8
09/100 il
b) 70 » oc - 10.6
og/100 ml
e) 16 • or - S.S
09/100 ml
d) »6.0 » or - 1*.9
09/100 ol
tMB)
GEIIBIL IIPOBIHXOI
Idolto (2«-<2 re) oorklog IB
reflolag, catting or veldlag of Pb.
loo Jereoy.
BITILS; mo; BLOOD: OIIIE;
OCCOPtTIOBIL BlXllOS; IEI JBISEt
•) I* ral« in 1 of » children toatod
prior to BIB* •creeaiog ood IB 3 of
100 daring BOO* «cr««Blng
b) syoptoootic chlldroo OB •dBlsilon
prior to oooo •eramlag
e| SjBptoBBtle cklUroB OB BdBlnloa
dicing BIBB Bcrcooiag
CblldroB IB Bovork. IJ. BUB og* 3
jt for *raptOBttic cklldr«B, 6 ft for
•ifBptOBBtic daring BB«< acrxning
POriod. 801 blBCk*. 1DMOC4 of BBBB
>cc«*ning 1967-69, BIBB oerooolog
(COB 1970.
ItTUSi LltD; BLOOD; LE1D fOISOniO;
inn poisoiuat cuLDBni in JEHSEI
i) BitBriBl
t| F«tll
Dcj it biBla. lotoroal loT«l>
•li»t«d bj factor of 2-3 IB lit*
ootooB iBd airly (later.
Suploa froi 1 koBpltilB IB
iBBBflll*. TB.
pttcntu IBTUS; TBICI nsBtusi
TIBIBSSIIt BlOODl Bill; COBPUlTXVB
lULDltlOBSl BXBCDBI; LElDl ClDSIOBl
SILBBIIBt 10BIDIOB; IBOli IIBC;
CCB1LT
•) oecopotloBolly «poa«d
t| CoatrolB
IcckorB Bipo**d to Pb 2- IS yi in •
FolTvloyl ctloridB factory. CoatrolB
oltaoot oceapatloail •ipocoro.
HID; BnUSl JtPIB) OOCOtMIOBlL
BUllDSl BLOOD! 01 HE; BUSUBIBBT
BtTBOOSs COBPtBlTIfl ITUBHIOIS:
IltTBBSl tOVlTS
•) Storage battavy oockorc boCoro
triatMBt Bltk Bloc lad TltaalB c
b) Ocoapatloiilly •ipoo«d battery
•orkaro, bafor* tr*Bta«Bt «ltk line
aad f itial* C
e) Coitrola
dl Storago battery locker* after 2*
•k treataaat Bltk Bloc aid vltialn c
lerker*. aged 28-60 yr. la battery
pint froa *-3» yr. 100 cootrol*
oitk BO kaoia Pb eipoaore.
iiioi IIBC: cotpni BBTIIS; nicB
ItllBRSl BLOOD] BLOOD SIIDB; ZBOlI
IIBOStOBIBS; OBIBBl DIBTS; ffflUB C
BEfEIEICE
Tltale, 1. P.
Jo*elo«, B.a.
ledaea, I.P.
Paolon, n.
1975
Brovder, i.
JOMlOV, B.B.
Loaria, D. B.
Laveakar, B.
FoBtir, J.
197*
BaglBB. I.J.
Bral, i.B.
scbolert, »-
•11*00, D.
Lar*ea, (.
Dyer. B.
Ban*ooE, B.
Scbaffoer, I.
BoffBoa, I.
Darle*, J.
197«
TOBOkOBl, K.
1970
PapaloBBBOO, i.
Seller, t.
Pfelffer, C.c.
1978
-------
7«9-92-1
tb
»tl 207. J. tt 327.* C, B? 1TW C. TP 1.77 •• Rg at 1000 C. 1 •• Rg at 970 C, 10 H Rg at 1160 C
(CORXBBRD)
Tissm
2*71
float
2*72
Blood
2*73
Blood
2«7«
Blood
2»75
B1004
-
uposon IOOIB
Xagootloa
Inhalation
IHLTTICIL
BBTBOO
us
us
113
ROBBBI
or MSB
•1 M
bt 69
o) 162
•1 56
b) 60
c) SO
d) SO
1559
1
8
B1MI
•) < 30 - gcaatac tku «0
ag/100 al
b) < 30 - gcaatar tku «0
ag/100 •!
et < 30 - gcaatac tku «0
ag/100 al
•t 0.9-3.3 awl/1
b) 1.0-3.2 aiol/1
c| 0.3-2.0 aaol/1
d) 0.«-2.2 aaol/1
!•». 5-33.6 ag/100 al
«) lot applicable
b) lot applicable
29-98 ag/100 al
(isrt
Hill
a) 33 ag/100 al
b) 26 ag/100 al
c) 2* ag/100 al
1.9 aaol/1
1.9 aaol/1
0.7 aaol/1
0.8 aaol/1
Radlana
lot glvaa
al 67 ag/100 al
b) «0 ag/100 al
52.6 ag/100 al
PIGt)
SIIIIIL XBTOBIkTXOB
a| Blgraat facaaockac ckildcaa
b| loa-facaaarkac ckildcaB. Badlcald
aacollad
e| Boa-fara«orkac cklldna. not
Badlcald •arollod
latal* la facaaockac boya ka«a hlgkoc
tacaaackac ?ltla (3S aad 2B ag/100
al. cwp«ctl*alT)
BLOOD; CBHB1EI: FlkBS; LIID; IE*
ICBI
a| Ualt (aaalaa la kaoMa altk load
aatac plpaa
b| Ckildna i» koaaa* altk load mtac
elpu
c) Idalt faaalaa la koaaaa altk
coppcc aatac plpaa
dl Cklldraa la hoaaaa »ltb ecppar
aatac plpaa
Mrala fall to aocaal altkla 6 aoatka
of caaaval e( load plpaa.
IIOODJ canoini Dimna iini;
t COLTS i corrui mot OIITID snaooB
Baaga oC aaaaa aftac factorial
gcoaplag bj aga« aax, aad blood
glacoaa-6-toa dakydcogaoaaa atataa.
taaka at 1-3 yc of aga (29.1 ag/100
al) aad 6 ji (28.1 ag/100 all.
Iftacta of otkar vaclablaa aaaaaaad.
Black cklldtaa of Soatk Pklladalpkla
aiaalaad ftoa Jalr 1972 to Barck 1973
at tka Cklldraa'a Boapltal.
Sigalfloaat oapcaaalon of baaatocclt
aad kaaoglobla aitk lacraaalag blood
load la tba 1-3 jc olda oaly.
mo: riiisn.mil ; CBIUIBBI BLOOD;
IRttSi BBBOOMBIBSl klCUL 9TODZBS;
Sill toil BlITBISi OBBkl til IS
a) Iklla laad-baaa-palatad acod «aa
cacaad foe kaat
b) tftac ckalatloa tkacapy. aad
caaaatloa of bacaiag of painted mod
5 yt old aklta aala
la ayaptoaa of laad polaoalag
HID; BLOOD I CBZLDIII; IRtLS: MIITS
Initial fb accoaalng
Pb >ockaca ckoaan foe atady attar
accoanlng taata aaggaatad «caaal*a
body bacdaaa. Tao koapltallcad altk
laad colic. Iipoaaca: 3-6 yc. tgaa
28-50 yc.
Tto aabjacta: laad colic
3 aabjacta: pcacllalcal Pb
aapkcopatky.
LtID; BRkLS; IRkt POUOHIQJ IBID
tOISOBTIO; BLOOD: 01 III: OCCDPkTIOML
BIZ1BOS: BIIIIIL BRkBOLISB
nnuici
Paccta, J.B.
Backaaa, B.J.
H79
Tkoaaa, B.P.
Blaood, p.c.
•aUby, B.
St. Lagoc. i.S.
1979
tdaboao]o> '•».
197a
OaCaatco, r.J.
laxaaca. J.
Bolfa. O.T.
Bagalac. B.
1975
•adaaa, I.P.
laaaoka. J.I.
•alaac. B.
llpat. Q.t.
Lyoaa. 1. 1.
Tltala, L.r.
Joaalov, B.S.
1975
-------
lead
7«-9-92-1
Fb
U» 20^. 2, HP 327.« c, BP 1710 C, TP 1.77 ,( Hq at 1000 C, 1 11 Hq at 970 C, 10 •• Rg at 1160 C
(COITIIOJD)
TISSOS
2«76
Blood
2»77
Blood
2»7«
Blood
2«79
Blood
2180
Blood
•IPOSUBt ROOT!
Deraal
Ingestlon
Inhalation
IRlLTTICkL
SET80D
1PDC-RIBK
MS
ROBBM
or cxsss
a) »9
b) SO
10(1
al 10
b) 12
c) 9
a) Rot given
b| lot given
c) Rot given
a) »0-70 ug/100 >1
b) < or • to 29 ag/100 al
•) lot given
b) lot given
0.3-2.9 uaolA
al 10.I-H9.7 ag/dl
b) 20.7-53.8 ag/al
c) 1*.5-51.8 ng/dl
«| 2.1 uaoles/1
b) 3.0 naoles/1
c) 3.1 ueoles/1
a) lot given
b) oat gi»«n
a) >>0 09/100 al
b) >60 09/100 al
I."1 ««ol/l
al 37.28 aq/41
b) 39.33 «g/41
cl 31.06 ag/41
(IBIT PIGB)
GCIIItl tirORHlTIOl
a) 1976, sacaa cont«ln«d 661 Pb (l/l|
b| 1977
C) 1978
Kgolic application! to coajonctl»«l
aicglni.
Kian child ad«ltt«d la 1976 «ith
[laablia attcibatabl* to mru.
H»D; CaSZ BISTOBIES; DIITBD IIKDOH;
BIOOD; COSBETICS; CHILDBEI: IB»D
toisoiiia
a) Biqh-Pb group
b) LoK-Pb groop
Cco«p> differed la (Ingu sacking,
•oathiag toy*, cb««lng pencils.
«ting paint or diet, pt«»al«nc« of
Pb in interior paint, soil ft 1«T«1«,
aand sarfac* Pb, and howohold dut
ft.
Childcaa in lochutoc, IT ar«a. age*
18-72 aonth*. Batched foe aaa, ac«a,
and social class.
LIID; LBaD POISOII10; IE* TOTK; DOST;
(ICa; CBI1DIII; BLOOD
a) ail cases. «07 living «lttln 20 ai
of •••!!«
t| 152 cases, all living ulthln 20 nl
o( sneltec
Concentration varied invecselT »ith
distance froa sneltec.
Children, aged 1-9 TT, living In
Idaho Silver Taller. «a controls
living sone distance fron silver
Talley.
SITUS; LBID; BLOOD; CHILDIBI;
SIELTBISi PICa: SBI; aGB; SOILS;
ccHPtittiTB mtoatiois; IIDOSTUIL
IBIaS; IDIBO; POPOUTIOI BIPCSOBE
levels at ezaslnation.
lead corkers, 21-63 vr old, telog
diagnosed and treated for lead
poisoning.
BITU.S; LMDi BLOOD; OII«S
CCmilTIVK natOaTIOIS; LB1C
COISOIIIO; JtPlI; OCCOfMXOIIL
•KalDS
a) plant i - atmospheric lead
0.09-0. 1S ng/cabic a
b) Plant B - atmospheric lead
0.025-0.15 so/cable s
c) Plant C - atnospharlc lead
0.13-0. 80 ag/cablc •
employees fcoe can-saking plants in
the onlted Klmgdos.
IRaLS; IBID; BLOOD;
BTILOITIOISl nODStllaL HBO » BUBS (
anno
Islan, R.
Bealr. B.I.
Davis. S.S.
all, I.I.
1980
charney, E.
Sayre, J.
Coalter. B.
1980
•alter. S.D.
lankel. l.J.
von Llndern, I.R.
1980
CO
O
00
iraki, s.
1980
Bishop. J.I.
1980
-------
laad
7139-92-1
Pb
It! 207.2, at 327.* C. BP 1710 C, TP 1.77 » eg at 1000 C, 1 aa Bg at 970 c. 10 aa Rg at 1160 C
(COITIIOID)
txssoB
2«S1
Blood.
calls
2«82
Blood.
cella
2«83
Sloo4,
cell*
2»8«
Blood.
plaaaa
2»»5
Stood,
plaaaa
2«86
Blood,
plaaaa
BIPOSOBE 100TB
Derail
(HLTTXC1L
RETROD
US
US
us
us
IORBB1
OF CISBS
a) 23
b| 52
c| 23
d) 52
a) «0
b) 25
c| 23
•1 23
b) 52
C) 23
d) 52
a) 6->
b) 35
BalGE
a) lot glfan
b) lot gtTan
c) lot gi»an
d) lot gi»an
a) 1».5-«1.<9 ag/100 al
b) lot glian
c) lot glTan
at lot 9 Ivan
b) tot glTan
c) lot gltan
d) Rot glvan
a) lot gl>an
b) lot glTan
(piEir
OB.ll
a) 26.0 ng/100 al
b) 26.7 ag/100 al
c) 25.0 09/100 al
d) 25.7 ag/100 al
a) 23.61 ag/100 al
b) (1.6 » or - 2.5
ag/100 al
cl 29.5 » or - 2.8
14/100 al
a) 0.75 ag/100 al
b) 0.63 ag/100 al
c) 0.62 09/100 al
d) 0.62 og/100 al
a) 3.1 09/100 al
b) 3.6 09/100 al
PICO
GIUUL IIPOtlaTXOI
a) Bothaca, orbaa
bl Botbaca, racal
c) laiboco, arbaa
d) tenbocn, coral
Icthaca and aaibocn In Italy, 23
pa lea In Parla, and 52 palca in cacal
acaaa.
llaD; HETlLS; BBIBCII; BLOOD: ITkLT;
OBBILICtL COID; COIftltTIVI
ITaLOlTIOIS
la*la«
HflBI; RBT1LS; LBID; BE11TB laUIDS;
CRIIDIRI; IGOlTSl LHO POISOIIIO;
BITlBOtllBS; BLOOD PUSH; BIOOD
SISBB; BOIIS: DIIIB; tnOHOTITB:
IltTRIOCnBS; BtOOD; RklBj IIILS;
SILtfa
a) High aehool atadanta ag»» 11-16 yc
tl Black aalaa and (aaalaa aoaa 10- 1»
jt In acaool adjacnt to a battacy
plant
c) Black aalaa «9»a 12-16 yc in
•choola got naar battvcy plant.
HID; HBTaLS; BLOOD; BLOOD PUSIl;
IIITRBOCTTI5; COIPIBITIYB
IfkLOaTIOIS: 1DOLBSCBITS
a) Rotaara. acban
t) Rothaca, coral
c) lanbocn, acban
d| ••nbocn, cacal
Bcthaca and navboca In Italy, 23
palca In Pa»ia, and 52 palca In cocal
acaaa.
tliO: HBTaLSi IBIBCII; BLOOD; ITkLT;
OBBILICaL COBDI COBPaliTITI
MaLDaTIOIS
a) Bxpoaad aockaca
c) Coatcola
Cd lavala utthlo nocaal llalta.
lockaca aaployad at laaat 1 |r at
iacondacy Ft aaalt«c and control*
tcoa naacby 11 procaaalng plant In
Calltocnla.
OITILS; IP.SIIIC; LI1D; BLOOD: BLOOD
PlISHa; Rill; COHPII1TITE
IflLOtTIOIS; IBtBIKI; IEOIOLCCIC
ailtFESTITIOIS; OCCOPtTTOIlL RaZtRDS:
IIDOSTUBS: SRILTEIS; CkLirOillt
l«»l«»
ItTIBI: RETtLS; IBID; HE1LTH RlItlDS;
CBILDBBI: IDOLTS; LttD POISOIIIG:
IIITJBOLITSS; BLOOD PllSRk; BIOOD
SIIDD; BOIES; omit; IDTOHOTITE:
IITTRIOCTTES; BLOOD; 8tIR: IIILS;
flttTk
BBFBIBICB
Ca*allacl. a.
Rlnoia, c.
Posxoll, L.
Polattl, P.
Bella, P.F.
1978
Poaaac, H.S.
1977
»ngl«, C.I.
Bclntln, B.S.
1«7«
Carallacl, ».
Hlnola, C.
Pozzoll, L.
Polatti, T.
Bolls, P.r.
1978
Balok. R.I.
Spiny, G.H.
Broun, c. P.
Hocgan, D.
Caaplon, D.S.
Bcovdy, B.L.
Talantlna. J.L.
Gonick, B.C.
Raaaaf, F.J.
Collar, B.D.
1919
Poanar, B.S.
o
v£>
-------
lead
•"O9-92-1
PI
ttw 207.2.
327.* C. BP 17«0 C. TP 1.77 •• Rg at 1000 C. 1 •• 89 at 97Q C, 1C •• Hq at 1160 C
(COITIIOED)
TISSOB
2a«7
Blood,
plasia
2«88
Blood.
seraa
2»8«
Blood,
*hole
2*90
Blood,
»nole
• •. • .. ii
2191
Blood.
(hole
2*92
Blood,
•hole
EXPOSORE BOOTS
,
Ingest Ion
Deraal
alaLTTXCll
SETHCD
its
us
us
us
us
IOS8SB
OP CaSBS
ao
al 10
b) 6
^^
a| 60
b) 30
c) 30
1309
a) 69
b) 35
BUG!
«. 5-7.2 19/100 al
a) lot given
b) lot given
a) 10-60 ag/dl
b) 12-38 og/dl
c) 12-»o ag/dl
a) lot given
b) lot given
c) lot given
d) lot given
•) lot given
f) lot given
al lot given
b) lot given
IE IN
Hot given
a) 0. 12 ag/1
b) 0.11 ag/1
a) 30 ag/dl
b) 20.8 ag/dl
cl 20.9 ag/dl
al 31.7 ag/100 il
b) 31.1 ag/100 al
c) 30.7 ag/100 Bl
d) 3».0 ag/100 al
•) 31.5 ag/100 al
() 31.3 ag/100 al
a) «1.3 ag/100 al
b) 22.0 ag/100 al
611(111 IirOlRlTIOl
Bigt acKool atadcnta agu ia-18 jrc
HtD; HETIIS; BLOOD; BtOOO PUSBl;
EITTBIOCITCS; COIPlBlTITE
EttLDMIOIS; tOOLISCEITS
l«Tla«
BtflBi; amis; LBIO; HBILTH H»I»IDS;
CltLNBIi IOOLTS; tUD POISOHIO:
ItltBOlITES; BLOOD HtSHl; BIOOD
SHOfl; BOIES; OIIIE; IOTOBOTITB:
tiTTHBOCITBS: BLOOD; RIIR; IIIL3;
SILITl
a) at* food cootaiiaatod nitb
••thTlaarcac;
t) controls
Buidanti of s»«d«n.
BEItLS; REBC01T; LUD; SIEDEI; BLOOD:
rOOD COITkBIIlTIOl
a) Bantall} ntacdad
cilldr«n-«tiologT ankaonn
b| Contcoli, aocaal children
cl Controla, •••tally retarded
caildrea - etiologj kaonD
Children froi tthen*, Greece area.
KaD; IBT11S; BEIT 11 milOinoi;
LltD POISOIIK; BLOOD; BIITBBOCITES:
CBILDBBI; CIEBCE; COBPaUTIVI
EfaLOHZOIS
a) Lodge B>pn«ana| area, aalei
b) aratlot tienae area, ealei
c) Orand lifer Iteane ana, aalu
d) lodge BipnsHaT area, feaalei
•) Ocatlot Ifeaie area, (eaales
() Orand liver tvenae area, (•••!••
lrea« are at Increasing distances
Ccoa 1 aajor coadiava: la Detroit.
Bigkec levels correlated »ltt poor
hoaaing and joanger age. lo
correlation between lead levels and
diatance (roe blgkiay.
Bestir J-5 If old*
BtTtLS; LBaD; IOC; CHILDBBI; S8I;
BIOOD; BICBIGII
a) Eipos*d workers
b) Controls
Cd levels vlthln noraal lisltx.
•orkers eiploved at least 1 jr at
aecondarr Bb saelter aad coatrols
(roa aearby 11 processing plant la
California.
BIMLS; tISEIICi LtaO; BLOOD; BLOOD
flaSIa; Bill; COBPtllTITE
IfaLOaTXOIS; EE1IIIO: IS010LOBIC
BIIIPISTITIOIS; OCCOP1TIOIU. R1SMDS;
IIDOSTIIIS; SBILTIIS; CI1ITOBII1
BEFEBEICE
Angle, C.I.
Rclntlre, U.S.
197a
Posner, H.S.
1977
Skerfvlng, S.
flaaoson, K.
Bangs, c.
Lladsten, J.
Byian, 1.
197a
Toaroakos, s.
Lvberatos. c.
Pblllppidoa, I.
cardlkas, C.
Tsoal, 1.
1978
Ter Baar. 6.
chadslnski, L.
1979
.
Baloh, 1.1.
Spivey, O.B.
Brown. C. P.
•organ, D.
Caapion, D. s.
Broidy, B.L.
Valentin*. J.L.
Gonlck, I.e.
Bassey, p.J.
Calver, B.D.
1979
(HIT PtOB)
-------
lead
7*39-92-1
n
n
It* 201.2, Bt 327.* C. IP 17*0 C. VP 1.77 •• Hg at 1000 C, 1 an Hg at 970 C. 10 » 19 at 1160 C
(CORimnD
TISSOB
2*93
Blood.
vhole
2*9*
Blood,
•kole
2*95
Blood,
vhole
2*96
Blood,
•hole
Exposan IOOTB
Oersal
Inhalation
kilt men
HBTHOD
US
IIS
US
IIS
BOBBIE
or CISES
a) «0
bl 75
a| 11
b| 18
c) 16
41 13
al 69
b) 35
IIBGB
.
a) 19.5-81 ag/100 si
b) 19.5-71 09/100 el
a) 39-61 ag/dl
b) 27-50 09/41
a) lot given
bl lot given
c) lot given
d) lot given
a) Sllgktlr <60-slightly
>80 ag/dl
b) Bat given
(I BIT
BBII
a) lot given
b) lot given
a) 50 ag/dl
b) *0.6 ag/dl
a) *8.6 ag/dl
bl 38.2 ag/dl
cl 31.3 ag/dl
4) 26.7 ag/dl
al 61.3 og/dl
bl 22.0 og/41
Plot)
GBEEIIL XIPOBBITIOI
*| 30-351 heaatoccit
b| 36-12% kaaatoccit
Preschool children fro* old boating
areas is Charleston sc.
8 ft ItS; HID; B100D; CBILOBEI; SOOTH
CIIOLIII
S| Botker, 6/6/75 to 9/23/75. peak on
8/13/75 and Ion on 9/23/75
b) Infant, 9/22/75 to 6/17/74. peak
•t blrtk (9/22/75) and 10/16/75, and
lov on 12/9/75.
pregnant 20 re old, in 3rd tcinestac.
vith saadpaper and torck ce acred
paint fros hoose. 3200 gs tveale
torn after *0 vk gestation.
Botker had Pb poisoning 20 days
tatoce delivery. Developsent of
infant nocaal at 10 so, bat at 12 ao
child ns at 8-12 ao in cognitive
skills.
BBTILS) HID; BLOOD! tlEIOTXC rtOID;
HID POXSOBIBOl II (UTS; IDOITS;
must PI i ITS
,.
a) 0-3 re old
b) 3-6 re old
c) 6-10 re old
d) 10 re and oldec
I) oat sasples (cos hoses indicated
toys and girls (fcoa 10 so tc 15 yr|
litk at least 1 patent nocking at
lattery factory in taleigk, K.
Ic sysptoss of lead posionlng
8ITILS; LEIO; BLOOtl IBID POISOniG;
CCCDPHXOIIL B1IIICS; IBOOSTnESi
DOST; CRILDItB; IOBTR CUOLIll
a) Sislter vorkers
ct Controls
lir levels for Pb, Cd, and Ir also
given.
tend sselter oorkers, lean age 12.5
yc, sean esploraent 11.3 re.
Controls. 11 rockers, sean age «'.7
re, nean eaploraent 8.* re. Ill fron
California.
IITILS; LBID; IISEIIC: CIDRIOfl;
BLOOD; IDOLIS; OCCOPITIOIIL EkEIRDS;
CORPIIITIVI EVIIUIIIOBS; CILIPOBIII
IBFBISECB
Ckisols, J.J.. Jr.
Relllts, E.O.
fell. 3.1.
Barrett, B.B.
197*8
slagh, B.
Donovan, C.B.
Banska*. J.B.
1978
Dolcoict. J.I.
Baacick, B.J.
O'taaaa, L.I.
Bootes. J.
Bkker, B.t.
1978
spiver. u.n.
Bcovn. c.p.
Baloh. l.i.
Caspion. D.S.
Valentine, J.L.
Rassey. r.J.
Bcovdy, B.t.
Calvec. B.D.
-------
t«ad
7439-92-1
PC
»t» 207.2, BP 327.4 C. BP 1740 c, 'P 1.77 II Hq it 1000 C, 1 •> Hg at 9"0 C, 10 •« Hg at 1160 C
(COKTIIOED)
risso!
2«97
Hood,
«hol«
2»9B
Blood.
•hoi*
2099
Blood.
tthole
2500
Blood,
whole
2501
Blood.
•hole
EIPOSOB! HOOTB
Infest Ion
Inflation
IMLYTICU
BETHOO
ms
US
us
SOH9»9
OP CISSS
931
1
115
•0
B»»GS
a) Hot given
b) Hot given
c) tot given
d) Dot given
95-136 ug/dl (4.6-6.6
uiol/1)
10-81 ag/100 il
5.6-27.4 ag/100 il
(IBXt
SEI»
al 24.8 » oc - 1.4
ug/dl
b) 22.0 » or - 1.4
ug/dl
c) 1ft. 0 + or - 1.3
ug/dl
d) 21.5 » or - 1.4
ag/dl
Seosetclc leans
115. 5 ug/dl (5.6
aaol/nl)
39.37 ag/100 •!
lot given
P»GB)
CBftltL I«fOBB»TIO«
>) 132 subjects Ccci arban cceieccial
acea (near tatterr plant)
t| S89 sabjecti fcci arban
ce*idential acea
c) 110 subjects froa sabacban acea
d) Ul subjects
Blood levels correlated «ith ale,
soil and housedost concentrations
statistical analysis done.
Children, 1*9 re old, froa three
general areas In Osaka, 1971-1977.
Ocean subjects eostlr black, sabacban
subjects «hite.
9IT»LS; LCaD; BIOICCOBOLITIOI;
IC01ESCEITS: CalLBBBi; BLOOO;
CCHPalaTITE ITtLOATIOIS; 4T1CSPHKBE ;
ORBM IBEiS; lEBStSKa
Scarce of Cb Bocgan's pecfased poeade
containing -Ploab. acet. 3t"
«-yr-old. «ith lest Indian parents.
In habit ot patting hoc fingacs into
cossetics and licking thes.
ervthcocyte pcotopocphycin levels
avenged 510 ag/dl.
BtlkLS; LEaD; BETH POISOIIIS; LBaD
POIS01IIO; PBOTOPOBPaiBIlS; flOOO;
EBITBIIOCITBS; CRItDBBI; OIITID
IIICOOR
l«»le»
llflll; HRalS; LEID; BEaLTR BIMBOS;
CBILD1EI; iDOLTS; I.EID POISOHWG;
BITlBOLItES; BIOOD PLiSRt; B100D
SIBOH; BOIES: OBIIE; IOTOBOTITE;
IBTtBBOCTTBS: BLOOD; Rail; IIILS;
SUITI
Prospective study. Pb significantly
related to blood protopocphyrin.
children, ages <1-7 yr. fcoa old
housing areas of Charleston, SC.
ItID; BLOOD; CBILDBBI; SEaSOBBBEIT
BE1BOOS; PBOtOPOBPBtlllS; SODTB
CIIOIIH; RITaLS
Bigk school stedents ages 14-18 yc
HID; BET1LS: BLOOC; BLOOD PUSU;
IITTRtOCITES; COIP1UTITB
SlaLQtTIOBS; aOOLISCIITS
BEFEBEBCE
Ingle, C.fl.
flclntire, R.S.
H74
•aldcon. H.».
1979
Posner, B.S.
1977
Chlsol*. O.J., Jr.
Belllts, E.D.
rell, J.S.
Barrett, B.B.
197*1
Ingle, c.B.
Eclntice, I.S.
197*
co
i-1
N>
-------
Kad
7W9-92-1
Pb
atl 207.2,
at 327.* C. IP 17W C, TV 1.77 » 89 at 1000 C, 1 •• Bg »t 970 C. 10 ea B g «t 1160 C
(COIHI08D)
TXSSOB
2502
Blood.
•hoi*
2503
Blood,
vbol*
250«
Bon*
2505
Boa*
BIPOSOIE IOOTB
Dvcsal
IMLTTIC11
»noo
US
us
us
IOBBBB
or caSBS
a) 17
b) 178
al 38
b| »8
•> 9
b) 13
C) 15
d) 68
•» 17
BlIOB
a) lot glT*B
b) lot gi»*n
a) 0.»3-«.00 aaol*s/l
b) 0.58-2.2 uaolts/1
a) lot gi**n
b) lot giT*n
c) lot gl**n
d) lot given
•) lot given
(•BIT
•Eti
a) 0.799 » or - 0.285
aaOl*S/l
b) 0.760 » or - 0.302
aaol*i/l
a) 2.17 naoles/1
b| 1. » moles/1
a) 0.6 ng/g
b) 1.0 og/g
c) 2.0 ag/g
d) 1.2 ag/g
•) 5.5 ag/g
PUGB)
GIIEI1L IWOBUTZOI
a) Bagnlac one*
b) lon-iaco
Sana, an •i*-ac*a eo«Mtlc,
contained 5-30S Pb («/•) (a* an 2»|.
Blood Pb In groapi not diCfannt.
lalan chlldna ttom 6* (aaill**. at
tk* Royal Bowltal foe sick children,
Glaogo* in 1979. lg*« » aonth»-1B
HID; COSBITICS: B100D; CBIIOIBI:
OIITBD nieces: COBPMITXTB
IliLOlTIOIS
a) cacdiovaacalac pati*>t»
b) locaotcnaiw pati*nt>
lo apparent «M*ct of age.
tatlants vitb aodarat* to ••«*[*
cardiac conditions and/or
aip*ct*nsion. Controla ititk no known
cacdioTaacnlac «ra(toaa. Ul one 30
jc old.
SITUS; CIDBIUB; 1UD; CtBDICtaSCOLal
CISBaSBSi OIITBD KXKDOBi
BTPBRTBISIOI; kOI; aDOLTS; SBOKnO;
CORPtBlTITB BfaLOallOIS; BLOCD; OBIIB
a) Sp*cU*n« Iron 3300-2900 I.e.
b| Sp*cin*nn (COB 2000-1600 (.C.
c| Spacing* (con 1650-1350 B.C.
d) Sp*cia*» (COB 1-750 i.O.
•I Cont*Bpocacr ap«cla«n«
Taln*a ac* a«di«na.
Sanpl*a (COB *ic**at*d ak*l*tora in
Sudan oc (ion antofaiea in Daaaark.
lg*« 16 to >55 yc.
BRIlSt LEtD: BOIES; TBBTHj
tOIOPSIBS) IDOLBSCBITS; IDOllS;
DIiatIK; SODIIl CORPaBlTIVS
IllLOaTXOIS
BkGIBSIOB; LBaD; IIIC; RBTtL!: TIICE
IIBBBITS; DlllltXia I1TB1; BLOOD;
BIOOD SBIOB; BB1BT; BOISS; OIXTBD
RIIODOU; ClllOt; DIITBO ST1TIS;
FIILIIO
IBTBBEICB
ttt*nbacro». i.l.
caapball. s.
Logan. B.I.
Go*l. K.H.
1980
Ih*ca. l.K.
iibb*ci*r. O.G
Edwards, K.t.
laldcon, B.I.
1980
GcandjcaB. P.
li*ls*B. O.T.
Saapico, X.I.
1979
UJ
M
U>
Shacott, I.E.
1977
-------
lead
HW 20--. 2, IIP 127. • C. 9P 17»0 C, »P 1.77 •> 1)9 at 1000 C, 1 II Hg at °70 C, 1C •• n q It 1160 C
(COITIIOED)
tissue
2506
Bon*
2507
Bon*
2508
BOD*
2509
Brain
2510
Bcaln
HI.POSOBI BOOTS
_,
\»»LTTIC»L
RETROD
Olthlxone
,
COloriietrV
IPDC-HXBK
us
Dithlzone
1U1BB3
OP CIS^S
•5
..
38
10
• 1
BUS!
a) lot given
b) lot given
c) lot given
d) lot given
a) 1.8-38.3 ng/g boo* ash
b) 3.5-25.9 aq/g boa* aih
c) 0.8-6."1 09/9 bone ash
4) 1.7-15.7 ug/g bone ash
lot 9l*m
a) lot given
b| lot given
{•BIT
1E»«
a) 19.09 ppi vet nt
h) 13.81 ppi »et «t
cl 7. ig pp( <(t lit
d) 1.12 ppi net vt
a) lot gives
b| lot given
cl lot gifen
d) lot 9lv*D
<0.1« og/g lit »t
a) 0.11 ppi vet vt
bl 0.11 ppi «et it
PIOEI
GCIIUL IIFOII1TIOR
a) Tibia
t| Skull, at of 15
cl lib
d) Tettebcae. «» o( >5
Skill and titia value* increased
steadily xitb age. libs and
terteteae leveled oft by age SO.
Saiples froa aatopaies froi the
Cincinnati area (1969-1971) cf «6
•hit* sales, aged 20-8 » jr. 19
traliatlc deaths, 6 destha doe to
drugs or carton aonoilde, 21 deaths
die to ledical canes.
IltD; BCTalSi BOIES; IOIP05! TISSOE;
0«IIB; HOSCltS; II1BSTIIES; BlitT;
SKIP: BLaDDll; stoatCH: Hall:
tlSISS; TBIBOID CLilDS; PIOS1ITE;
tlOOD; IOBEIU 6LIIOS; 1.0165; SPLEEI;
PIICIBiS; IIDIBTS; tlTBR; aORa;
lOTOPSIBS! OBIO; BIOACCOIOLIIXOI
a) libs, autopsies
r| Vertebrae, aatopslei
c) libs, skeletons
d) Vertebrae, skeletons
Ft Increased ulti age in botb groups.
• icept 0 to 2-yr-old skeletons had
high levels.
1975 aatopsies of 21 iidlvldoals.
children and adults. 17 skeletons
fcoi 600-800 I.D. all froa the Been
area.
HID; BOIBS; 10TOPSIRS; SlItniLalD;
BElSOIBBBIT BBTBODS; COIPIMTITB
IIILOaTtOISl IIB5I VBITBBIIB
Bevies
BITIEIi BETaISi IBID; BlaLT! R1UIDS;
CBILDIEI: 1001TS; HID POISOtTIO;
ttTlBOlITBS; BLOOD PLISBa; BIOOD
SIBOB; BOIBS; OBIIE; iOTOBOTIVB;
EBTTRIOCITES; BLOOD; lalli BalU;
SUITt
tltopsles-endogeioss level*.
IlaDS BBTaLS: tITII: Blalli BEIIT;
StLEEl; IOIOS; BlaSOIIHBIT S IT BODS
•) Cortical tissue (ros frontal lobes
of cerebral, 39 of 41
t| Bednllary tlssve froi frortal
lobes of cerabrui
laiples Cros aetopsies froi the
Clnclanatl area (1969-1971) cf «6
iklt* sales, aged 20-8 a yc. 19
tranatic deathi, 6 death* dea to
drigs or carboi aonoilde, 21 deaths
die to Bedical cai*es.
HID; BBTILS; BOIIS; IDIPOSE TISSOE;
QIIIE; BOSCUS; IinSTIIES; BBIK;
SHI; BLIDDBB; STOBICB; BIIXI;
T.ISTES; TBIIOID 01. II OS; PIOS1ITE;
HOOD; IOIBI1L SLIIDS; LOfflS) SPIBBI;
PIICMI3; (IOIBTS; 1IVBI; 10RI;
lOTOPSIBS: OHIO; BIOlCCOHOlinOI
IEFEIEICE
Gross* S. B.
Pfltzer, E.t.
Teaoer, D.I.
He hoe, 3.».
1975
olrlch, i.
1978
Posner, B.S.
1977
F arris, P.r.
Poklis, I.
Eriesiann, O.E.
1978
Cross, s.B.
Pfltier, I.I.
Teager, D.I.
Kehoa. B.I.
1975
-------
lead
7M9-92-1
Itf 207.2. BP 327.* C, BP 17(0 C, TP 1.77 » 19 »t 1000 C. 1 •• eg at 970 C, 10 •• 89 at 1160 C
(COITIIDBO)
TXSSOI
2511
talc
2512
laic
2513
pair
BXPOSOiB IOOT1
Deraal
1HLTTXCIL
RETBOD
US
US
us
IOBBEB
or cisss
al 69
b| 35
al 20
b) «1
a) 126
b| 90
d 71
d| 85
el 77
tl 28
h) 10*
11 102
11 109
MIGB
al lot given
b) lot given
a| <5-S5 naolAg
b) 5-720 aeol/kg
a| lot given
b) lot given
c) lot given
d) lot given
el lot given
f| lot given
SI lot given
) lot given
1) lot glv*n
j| lot given
BB1I
al 206.9 «g/g
b| 12.3 ag/g
a| 10 aeol/kg
b) 115 Mol/kg
Radlaa*.
al 11. 7« ag/g
b| ia.07 gg/g
c| 17.13 ag/g
d| 10.39 ag/g
el 1*.SO ag/g
f| 12.88 ag/g
g| 11.86 ag/g
h) 17.52 ag/g
1| 13.95 ag/g
11 10.97 ag/g
smut uroiiinoi
a) lxpoa«4 «ock«n
c) coatcoli
Cl 1«»«1» ditain nocMl llilti.
•ockccs •iplor«A at l«a«t 1 jc at
ncoao'acy tt m«lt«c aid control*
tea* uachr 11 pzocMalng plant In
Cillfornla.
BBTtLSi tISlltC; LIID; BLOOD] BLOOD
PltSlat Ball! COBP1MTITI
IflLOMIOBSi BBUIISi IBOIOLCOIC
OCCOPlTIOIaL BaUBDS;
cuironxi
a) control*, no kacnn occopatloul
•zponn
b) Occupational «zporan froi 1 aontn
to 25 yc
Control*. ag«d 1B-«« rr, •iploycA In
alll procaaalng «aibl« oil* aal fatty
acid*. BicoMd factocy >ock
-------
lead
7019-12-1
Pt
UW 207.2, HP 327.1 C, BP 17«0 C. VP 1.77 aa Hg at 1000 C, 1 aa Kg at "0 C, 10 la <\1 at 1160 C
(COITIIOED)
TISSUE
2SU
Hair
251S
Hale
JS16
naic
2S17
R«act
2418
Heart
2519
Intestine
SiroSOBB BOOTS
IXII.TTICU.
METHOD
US
us
IP DC- SIBK
IIS
DlthlXOne
Dlthlzou
III
OF
2SO
_
6
9
43
as
ROUSES
a MICE
2.0-360 'jg/g
1.6-2.1 PP«
lot given
Not given
a) lot given
b) lot given
12. a 119/9
Geoaetric aeaa
2.0 ppa
<0.1» ug/g vet vt
0.08 ppa vet vt
a) 0.12 ppi vet vt
b) 0.07 ppe vet vt
GEIIBAL IiroBfl»TIO»
Cata available for age, sez. and
occupational gronpa.
Subjects Croa coaaaoltr of 6C,000
Fvople, a gel 1 to """ jr.
SITUS; LEaO; BHIB; »OE; SEI;
OCCOPaTtOlal BIZlHtS; COHPaBITin
ttltatTIOIS; nil ZEttalD
lt«D; HalB; SETllS;
litBODS
levlev
BtTIEI; BETalS; LEID; HEILTB RaSiBDS;
CBILDBIli ICOLTS; IBID POISOHIG;
BIT1BOLITES; BLOOD PLtSBl: BIOOD
sieoB; BOIES; OBIIE; »OTOBOT:»B;
IITTRBOCTTES; BLOOD; HUB; ItlLS;
SUIT!
-endO9enoae levela.
1MD; BEIILS; LlfEB; BBtll; BE1BT:
SflEEl; LOIOSt IBaSOBEHEIT HITBOOS
Saiplea fcoi aatopalea (to* the
CiadDDatl acea (1969-1971) ef a«
vhlte ealel, aged 20-8* jt. 19
tcauatle death*, 6 death* doe to
draga oc carbon lonozlde, 21 deaths
dge to eedlcal eaaaea.
1110; BETHS; BOIES; aDIPOSB TISSOE;
DBIfB; BOSCtIS; H1BSTIIES; BEWT:
SHU; BtaDDEB; STOBtCR; Bill I;
11SIBSS tniQID GLalDS; PtOSUTB;
HOOD; aDBEIll GLalDS; LOISS; SPIBEI;
PIICIBaS; KIDRTS; 1ITBB; aOFTlj
oaio; Biotccmioiatioi
a) JejODQl. level a decreaoed vlth
incceaelng ege
t) Cecea
Saeplea tea* aatopalea froa the
Cincinnati ecee (1969-1971) cf ««
vhlte ulew. aged 20-8* jc. 19
traoaatlc deatha. « death* doe to
drag* oc carbon aonoxida, 21 deaths
dee to eedlcal caoiea.
HID; 9BTIIS[ BORS; IDIPOSE TISSUE;
OBIIE: BOSCIIS; IITESTIIES; BEIBT;
SHI! BllDDBB; STOBICB; BB1II;
IISTBS; TBT10ID QUIDSJ PIOSUTI;
BIOOD; IDIEIIl GLIIDS; IOIOS; SPIBEI:
rllCBElS; JIDIETS; HTEB; lOtTl;
UTOPSIES; Ono; BlOaCCOIOllIIOl
Peeves, R.D.
Jolley, K.«.
Buckler, P.O.
1975
Seta, T.D.
Baun, H.Z.
sircar, S.
1975
Posner,
1977
Ferris, T.T.
Poklls, I.
Gcienann, G.E.
1978
Gross, S.B.
Pfitter, E.I.
Teager, D.I.
Kehoe, B. i.
1975
Gross, s.a.
PCitzer, E.I.
Teager. D.I.
Kehoe. B.I.
1975
(IBIt PIGB)
-------
lead
7« 39-92-1
Pb
Itl 207.2. 8? 327.1 c, BP 17*0 C, fP 1.77 » 19 at 1000 C, 1 •• Hg at 970 C. 10 » 89 at 1160 C
(COBTISOBD)
TXSSOB
2520
2521
Kidney
2522
Kidney
2523
Liver
252*
EXPOSURE ROUTE
I11LTTICIL
BBTBOD
x-ray spectres
Olthlsone
ES
IPDC-HIBK
US
X-ray spectroa
IORBBB
OP CiSBS
a) a
b| 7
»5
a| 119
b) 52
c) 66
10
8
IIEGB
a) Bot given
b) Bot given
a) lot given
b) lot given
a) lot given
b) Bot given
c) Bot given
Bot given
Bot given
(BEIT
BEtl
a) 7.06 ppa dry «t
b) 7.85 ppa dry it
a) 0.79 ppa vet vt
b) 0.«8 ppa vat vt
a) 5.76 ppa
b) ».02 ppa
e) 5.07 ppa
1.61 ug/g vat vt
5.43 ppa dry vt
PlGE)
GBBIB11 IIFOIBITIOI
a) Bedalla
t) Cortex
2 saaples per case. 2 analyses per
aaaple.
197» antopsiea of 10 Pisa Indians, a
Papago. and a Creek Indian.
FOTassioa; CU.CIOB; IROI; COPPBI;
IIICj BOBIDIORi 1ICIBL; LB10; BBT1LS;
TlaCI ELEBEITSI LIVER; SPIBIR; aOBTa;
K1DBBTS; IDIPOSB TISSUE; PIBCBEIS;
IEISOIBBBBT BRBODSi aOTOFSIES
a) Cortes
t) Bedalla, M of «
levels decreased vita increasing age.
People vita nephrosclerotic disease
had levels of 0.56 pps, cospared to
0.93 ppa for others.
Saaplea fros aatopalas fros the
Clocianatl area (1969-1971) cf «6
•hite sales, aged 20-8 « yr. 19
transatlc deaths, 6 deaths doa to
drags or carbon aonori.de, 21 deaths
doe to sedlcal caases.
KID; BBTalS; BOBBS; IDXPOSB TISSOE-.
ORXBBt BOSCIIS; XBUSTXBIS; BBIBT;
SBXB; BLtDDBB; 5TOIICB; BBlII;
IBSTBSl TRTBOXD CURDS; PtOSUTE;
CUODl 1DBBBI1 CURDS; LOBGS; SPIBBI;
PIBCBBIS; KIDIBTSs LIVBB; aOBTa;
inoPSIBS; OHIO; BIOaCCOHOlaTIOB
a) Bo renal disease
b) Icate renal failures
c) Chronic renal failures
a) and b) different (P<0.02). b) and
c) different (P<0.05)
Talaes are dry vt basis.
latopsles at OCLl Bospltal.
IBaCB ELBBEITS; BETILS; IDTOfSIBS;
C1LIPORII1; tXDIETS; LIVER; SFIBCB;
CISEISBS; BTPBBTBBSIOB: SODXOH;
BCTissioai ciLcion; PBOSPBORDS;
BIGBBSIOB: CaOBIOB: BXIC| COCPEB;
XIIDs IROI; 8MGIBBSB; IIOBIIDR;
SXIICOI; TXtllXOB; COBUTj IICIEL;
60LTBDBIOB; TIB; CBBOaXOB; S1BOITIDB;
CIBIOR; IITBIDR; SILTBR; fUlDIDB;
COIOI
aitopales-esdogenoas levels.
HID; BBtllS: LIVBB; BRalB: EBaRT;
SPLEBB; LOBGS; REaSORBBEIT 8 IT BODS
2 aasples takan par case. 2 analyses
ran per snecle.
147« aatopsles of 10 Pisa Indians, a
lapago. and a Creek Indian.
POTaSSIOB; CaLCIOB; IROI; COIPBB;
ZIIC; ROBIDIOB; BICKEl; IBID; BBTaLS;
TlaCS ELBBBITS; LIVER; SPLEEI; aORTI;
HIDIBTS; IDIPOSB TISSUE; PlECBRaS;
BIISOREREBT BET BODS; aOTOPSIIS
BBFBBBBCB
--
Bangelson. B.F.
Rill. B.B.
liaison, K.C.
Batougk. D.J.
chrlstensen. J-J.
Iiatt, B.B.
Richards, D.O.
1979
Gross. S.B.
Pfitzer, B.I.
laager, D.I.
Xehoe. B.a.
1975
Indraprasit, S.
Ilesander, G.V.
Gonick, B.C.
197 a
Farrls, F.F.
Poklls, 1.
Gclasaann, G.E.
1978
Raagelson, I.F.
Bill, a. I.
liaison. K.K.
Batough, D.J.
Christensen, J.J.
Itatt, R. B.
Richards, D.O.
1979
LO
-------
Had
7»3»-92-1
Pt
«« 20T.2. DP J27.« c. SP 17«0 C. fP 1.71 aa Rg at 1000 C. 1 mm Rg at atop*le«-endogenoai level*.
HID; 8ET>LS! LITII; Bllll; EBkBT;
SE1BBI; LaiQS; BUS01EBEIT SIT BODS
sections of lugs fros taejecta uno
had been bitasinons coal aintra for
33-50 yr.
BFTILS; TP.ICI BIBIIITS;
BiBIORl BEIIILIOB: BOHOIj CRBOHIOR;
ccppEi) sniuiOB; iioi: LUC;
BIOIBJIOBj UBOIBESB; BICIK;
SIIICOI; SI1TEI; Til; TITtlZOB!
TtllDIOR; LOWS; COil; OITTEC SUTES;
OOIBTI: RXIIULS
Inclades apper and lover lobes, and
lyaph nodei of lung, addition,*! data
available.
Sections of Inngs fros smbjscts «ho
had been bltaalnoss coal alnars for
12-50 yr in lalelgh Coanty. Bast
flrginla.
BtTltS; TlaCI ELEHinS: COaL;
BI1TLIIOB; COBtlT; CnOUOH; COPPEI:
HOI: iUD; BIGIBSIOR; RilGinSEl
IICHLI TITliniBj ItllDIDR; HIC;
IOB1S; CORPlUTin Bf»LO»TIO«S;
SXLXCti QDMTSt IIEPB BODES; IBS!
•XIOXBXa
Gross, S.B.
Pflt«*r, E.I.
Teagec, O.K.
Kehoe, B.».
1975
Indraprasit, s.
tleiander, G.T.
Gonlck. B.C.
197*
00
Parris. T.T.
Poklls, a.
Griessann. a.I.
1978
Crable, 3.1.
Ke*nan, B.C.
•olodcs. r.l.
Knott, B.J.
Bolts, J.L.
Gorski. C.R.
1967
Koenan. B.6.
Crable, J.T.
Ssalliood, i.l.
Carlberg, J.I.
1971
-------
imd
7*39-92-1
n
Itl 207.2. BP 327.« C, BP 17«0 C. TP 1.77 •• Ig at 1000 C. 1 •• Rg at 970 C. 10 •• Ig at 1160 C
(COITIIOBD)
TissoB
2530
Ling
2531
Lang
2532
lug
2533
Basel*
253"
1*11
EiPosoBB soon
1I1LITIC1L
HBTBOD
Dltkicon*
olthlzon*
Dlthlxon*
DithiXOM
IOBBBB
or CMBS
66
66
•2
M
B1EOE
2.9-I.C ug/g dry *t
2.9-». 6 tg/g drf »t
lot giv*n
lot gl»«n
(I BIT
nti
3.8 ag/g drf «
3. 8 ag/g drf >t
0.36 pp* «*t «t
0.07 ppi v*t it
P»SB|
GBEBBll IIPOBIHXOB
3«».
BIIUS; T»»CI BIBBBIIS; COIL: SIUC1;
BIBILLIOB; CRBOIXOB; COPPEIi IIOBt
HID; BtQBBSZOB; BII81BBSB; BXCKBl;
TIUBIOB: TIHDIOB; UBC; IDBOS)
CCBPlBkTXTB ETHOIIIOIS; 1BS1
flBSIBIi
S*lpl«« ftOI MtOpSiU fCOl th«
Cincinnati ana (1969-1971) cf «6
•hit* aal**. agad 20-Ba yr. 19
tcaaaatle 4*atk*, < taatli* ao» to
dcag* oc cactan aonozld*, 21 daata*
do* to a*dlcal €**••*.
HID; BBTalS; BOIBS; IDIPOSB TISSOB;
OIIIB: BOSCIES; XBTBSTIIBS; EMBT;
SKIli BLIODBB: STOBaCB; BBtll;
1ISTBSI TBTBOXO GLlBOS: PBOSUTB;
ClOOD; tDBBIIL 611BDS; LOBGS; SABBI;
PIBCBEtSi BIDBBTS; tTTBB; tOR>|
tOTOPSIES; OBIO: BIOaCCOBdlinOB
lufarioE left c*cta*
Slaplvi fco* a»top«l«* tco* tk«
Cincinnati acaa (1969-1971) cf «6
•hit* ul**. ngad 20-8* jt. 19
traaiatlc d*ath*( 6 daath* do« to
dcag* or carbon aonoilda, 21 death*
da* to i*dical caan*.
lltO; BBTaLSl BOIBS| aOIPOSB TISSUE:
OBIBEl BOSCIES; II1BSTIIES; EBaBTi
SBIli BLtDDEB; STOBaCB; BBall;
TESTBS; TBTIOID GLIIOS] PBOSUTE;
HOOD; aDKBIIL QUIDS; LOIOS; SPLEEI;
PIBCBEtS] KIDBETSl LITBB; lOBTa;
tOTOPSIBSl OBIO; BIOlCCOHOlillOl
IETIBI; HETILS; LEIC; BEILTB BlUIDS;
CIILDIBI; aDOLTS; IBID POISOIIIO;
IITIBOLITES; BLOOD PLISU; BIOOD
SEIOB; BOIBS; OBIBE; 101OBOTI7E;
IBTTBIOCTTES; BLOOD; BlIP; BULS;
SILITt
UPUBHCB
SM«t. D.T.
CCOO**. I.B.
Crablo. J.T.
Caclbacg. J.B.
Lalnaact, l.s.
197«
Carlbarg. J.B.
Ccabl*, J.T.
Uatlaca. L.p.
lorcla, B.B.
Bolts. J.L.
Baoar, p.
•olovtex. P.I.
1971
Gco*a, s.B.
PfltX*C, B.I.
Taagac. D.I.
X*ho*. B.a.
1975
Ul
M
\D
Gro**, S.B.
Pfitur, E.I.
T*ag*r, D.V.
K*ko*. B.I.
Pomat, B.S.
1977
-------
Had
•"•39-12-1
207.2, tit 127. • c. BP 1740 C, »P 1.77 i> flq at 1000 C, 1 an Hg at 970 C, 10 aa Hq at 1160 C
(COITTIOED)
TISSUE
2535
Pancraaa
2536
Placenta
2537
Proitata
2538
SaltTa
2534
Skin
BIPOSOBB RODtt
UUTT/ICll
KBTH.OD
DithlZOD*
Dlthlzono
Dlthlzono
•DIBtl
OP CISBS
«s
23«
•3
HUGE
lot gl»en
lot givan
lot gl*«n
lot gl»an
0.46 ppa net vt
1.B3 » oc - 2.56 ug/g
0.20 ppa *at lit
0.08 ppa cat it
(KIT P1GB)
GEIIB1L IIPOIHiTIOl
l«»«l* d*ec«aM4 nith Incceaalag age.
5i«>, J.
197«
GCO», 5. B.
PCltnr. E.I.
T«ag«c, D.I.
(•boa, B.I.
1975
Po*n*r, B. s.
1977
Gcoaa, S.B.
PtltMC. B.I.
Taagac. D.I.
R«ho«, I.I.
1975
U)
N)
O
-------
laad
7*39-92-I
»tl 207.2. BP 327. • C, BP 17W C, TP 1.77 •• Bg at 1000 C, 1 II Hg at 970 C. 10 •• Bg at 1160 C
(COITIIDBD)
ixssoB
25*0
SplaaD
25*1
Jplaen
25*2
SplMB
26*3
SplMn
25»«
St Ditch
•
E IPOS DM BOOTH
IIILTTICIL
BBtBOD
IPDC-BIBC
US
X-cay apvctroa
Dltaison*
ES
Dithiiona
(
1
tOBBBI
OP CIStS
10
*
•3
a) 63
b) 36
e| 68
«S
lalGB
lot gl»an
•Ot 9lV«B
Bot glran
...
a) lot giT«B
b) lot gi»«n
c) lot given
lot glvan
(•BIT
BBII
0.22 ug/g vat «t
25.1 ppa dry «t
0.33 ppa «at «t
a) 7.85 ppa
b) 12.6 ppi
c) 8.81 ppa
0.10 ppa «at vt
P1G»|
GBIBIal IIF01BITIOI
litopalaa-endoganoaa l*T«la.
L»D! amis; LITBI; B»II; BB»H;
SELBBI: lOieSl BBtSOUlBIT BET BOOS
2 *aapl«a p«c c«««. 2 analy*** p«r
«iapl«.
1J7« aatopaiaa of 10 Plaa Iadi«n«, a
Papago, and a Cc««k InAtaD.
POTtSS IBS; CIICIOB; IIOI; COFPII;
1IIC; 10BIOIOB; IICIBL; LBlDi BRiLS;
tllCB BIBBBHS: LIIEI; SPLBBI: »OIT»;
IXDIITSi 1DIPOSE TISSUE: PIICBBaS;
BltSOIBBBIT BETBOOS; IdTOPSIIS
5a«pl*a froi igtopaiw fcoa th*
Cincinnati ac«a (196»-1971) et «6
»klt« aal«a> ag«i 20-8* yc. 19
tcanaatlc dvatki. 6 daath* AM to
dtaga oc cacboB aonoxlia, 21 d«ath»
dM to avdlol caaiaa.
llaD; SBtllS; BOI8S; tDIPOSB IISSOB;
OlIIEl BOSCIIS; II1BSTXIBS; BBaBT|
SHI; BL1DDEI: STOBiCB; Hall:
HSIBS: TBIIOID GtllOS; PIOSUTB;
BtOOO; kDIBIU GlllDS; LOIGS; SPLEEl;
PIlciBtsi ilDlBTSt lifBl: iORa;
IDTOPSIB5; OBIO ; BIO»CCOBOl»IIOI
a) lo renal dls*u«
fc) teat* r«nal fai larva
c) ckronic canal
-------
lead
H39-12-1
• t« 207.2. a? 327. » C, 8P 17(0 C, TP 1.77 a* Rg at 1000 C. 1 >•
at "TO C, 10 •• Rq »t 11SO C
(COITI10SD)
TISSUE
25«5
Teeth
25«6
teeth
25«7
Teeth
Teeth
EXPOSURE ROOTE
tllLTTICll
lE'BOO
US
IPDC-HIBK
us
1ST
OF CISES
al 9
b| 13
c) IS
d) 68
e| 17
a) 10
b) 66
c) 23
d) 20
b| 282
a) 28
b| 28
ORB;*
CISES
9
13
IS
68
17
10
66
23
20
282
28
28
MICE
a) lot given
b) lot given
c) lot given
d) lot given
e) lot given
a) lot given
b| lot given
c| lot given
4) lot given
al 0-<200 ag/g
b) 0->«00 ag/g
a) Rot given
b) lot given
1B»I
al 0.9 ag/g
b) 2. 1 aq/g
c) 5.0 nq/g
d) 3. 2 ag/g
e) 25.7 ag/g
al 6.2 ppa
bl 3.1 ppa
c) 5.3 ppa
d) •'.O ppa
a) lot given
b| wot given
a) 71 ppa
bl 53 ppa
GEKHL IITOBRmOI
a) Speclaens froa 3300-2900 E.C.
bl Speclaens froa 2000-1600 E.C.
c) Speelaens fros 1650-1350 E.C.
d) Speciaena fro* 1-750 1.0.
e) conteaporarf speciaeas
Redlana.
Saaplea froa excavated skeletons in
Sudan or froa autopsies in Oanaark.
Iges 16 to >55 rr.
firms; LEaOi BOIES: TSETR;
lOTOPSIBS; IDOLESCEIT5; kDOLlS;
DEIIURK; SODII; CORPaRaTIVE
EVIlOaTIOIS
a) lashvllle black children
b| lasavilla vhlte children
c) lest Tennessee ehite children
dl lest Tennessee black children
•ddltional data available.
106 teetb troa lashvllle doncrs froa
an eleaentarT school la a
•Iddlc-class area, and froa day care
centers in lev-incase areas. «7
teeth fro* lest Tennessee donors fro*
clinic for indigent children. 87
sales, 66 resales.
TEETH: LBaDl HSTaLS; TSUI ESS IE;
CBXLOIIR
a) Low eiposvre, sean school interior
lead dast level of 613.75 ag/g
t| Righ eiposare. *ean school
interior lead dost level of 32«7.«
ng/g.
Dentine froa asvaptoaatlc tint
graders of districts 5 and 8.
Chlladelphia, P»
RITllS; LE1D; TERTR; CRXLDREI;
CORPiRlTXVB EVUOITIOIS;
ItllSTLVIIII; IIDOSTMU 1R1IS
a) IE Bristol
b) SI Bristol
Cersaaent preiolar teeth collected
tros school dental clinics in
Bristol. United Kingdoa.
BETU.S: LB»D; UK; CIDHIOR: COPPER;
ItETR; CRXLDIBI; OIITBD RIRQCOR
REFEBEICE
Graadjean, P.
llelsen, O. T.
Shapiro, I.I.
1979
Chataan. T.
•ilson, D.J.
1975
Reedlesan. a.L.
Shapiro. X. R.
197a
., „
Stack. R.T.
Barkitt, t.J.
lickless, G.
1975
(IRtT PkGSI
OJ
-------
7*39-92-1
n
III 207.2, IP 327.« C, BP 17*0 C. »P 1.77 aa 19 at 1000 C. 1 •• 89 at 970 C. 10 aa Ig at 1160 C
(COITIIOBD)
TISSUE
25*9
TMtk
2550
TMtk
2551
Taatla
_
2552
Thyroid
gland
11
EXMSOIt BOOTH
lagaation
—
aiaiTTICaL
BBTBOD
US
Ditkisona
Dlthliona
IOBBE»
or casss
a) 22
b| 10
c) 10
d| 22
a) *
35
•3
*0
UIGB
a) lot gi»an
b) lot giTaa
e) lot gl*an
d) lot giTaa
•I lot gl»an
200-3550 ppa
.
lot givan
lot givan
(•BIT
mi
a) 212.9 09/9
b) 153.9 ag/g
c) 171.0 ag/g
d) 67. B ag/g
a) 19.0 ug/g
1790 ppa
9.15 ppa »at «t
O.^i ppa «at «t
?»OS)
GEIEIll IIFOIBITIOI
a) Bipoaad-old acbaa koaM
r) Bipoaad-nan arban kooaa
c) Control-old acban hoaaa
d) coatcol-naa arbaa konaa
a) Control-naa aabarban or roral
koaoa
lalatioaahip batraaa dantal «d blood
tt qlvaa.
tipoaad cbildran llwlag la ot
acandlng aack tlaa la old having and
altk hlatory of plea. Ill aipoMd
cklldraa kad poaltlfa copcopcrpkyrloa
la oclaa. Control ckildran living In
keaalag la good atata of rapalr. BO
hlatory of pica and ao
coproporphyrina da tact ad In arlaa.
ill eaaaa agad 7 yr or laaa.
BRILS; IBID; TBBTB; BLOOD; CBILDBII;
EIC«; Tliazila
Caabcldga, Bl achoclchlldcan
TIICB nCRBITS: BETUS: S1IORIDB;
HID; SOOIOB; aiGiBSWB; 1IIC;
riOOIIDB; BISSlCBOSBTtS; CBItDBEl;
T1ITB; 1BISOMBBIT ISTBODS
Saaplaa fcoa aatopalaa froa tha
Cincinnati araa (1969-1971) cf ««
«klta aalaa, agad 20-B* yr. 19
tcaaaatlc daatka, 6 daatks daa to
dcaga or carbon aonoilda, 21 daatha
daa to aadlcal caaaaa.
llaCS SETltS: BOIES; aOIPOSB TISSOC:
aniE; soscttsi xmsniESi BEAIT;
SKIli BUODBIj STOBaCIS BBUI;
ttSTBS; TBIIOID OLIIDSJ PIOSUTE;
HOOD; 1D1BIII, QUIDS; IDIOSi SPLBBB;
Clients; K I DIETS; LUBB; aoRI;
aOTOPSiBsi oaio; BioaccoBotanoi
.
Saaplaa fcoa aatopalaa fcoa tha
Cincinnati ana (1969-1971) cf *6
vklta aalaa, agad 20-0* yr. 19
tcaaaatlc daatka, 6 daatka daa to
dcaga or cacbon aonoxlda, 21 daatka
daa to aadlcal caaaaa.
HID; 5ETUS; BOIES; aVIPOSE TISSUE:
OKIE; BOSCIU; XITISTXIISl EE4BT;
SIIC BLtDDBB; StOBaCI; BIIII;
TtSTES; TBTIOIO SHIDS; PBOSULTI;
ElOOD; aDIEiai. Oil IDS; I.OICS; SPLEEIi
FIICIEtS; KIDIITSi IITSI; aoRa;
aoroPsiBS; OBIO i BioaccoBoiauoi
IBTBinCB
da la Bacda, B.
Shapiro, I.B.
1975
BrndaTold, r.
lada, a.
aaaandan, B.
Fakkaa, T.
1975
.
Oroaa, S.B.
Ffltxar, B.I.
Taagac, D.V.
Kahoa, B.t.
1975
Croaa, S. B.
Pfltxar. E.a.
Taagar. D.I.
Kahoa. B.a.
1975
N>
bo
-------
Uad
7C-9-92-1
tt
ItV 207.2, HP 321. a c. IP 17«0 C. IP 1.77 >• Kg at 1000 C, 1 •« Bg at «•><) C, 10 II Hg
b) 20«
a) 11
b) 13
a) 76
b| 22
BARGE
0.1-9.5 ag/1
a) < or • 50 ug/1
b) > 50 ug/1
a) 35-59 ag/2» ht
bl 1
b) 0.72-».20 aiol/iiol
CaEDTa adninietered
al 10-390 ag/1
b) 00-50 ag/1
IBM
lot given
a) lot glf«n
b) (at given
a) «i.3 ag/2* he
b) »69 og/2« he
a) lot gi»«n
b| lot gi»«n
a) ee ag/1
b) 19 «g/l
(•err ?»OB)
GEItltL IIFOBHtTIOl
ftoa graph. Peak 4-6 days a(t«r
itartlng teaat««nt. Lov,
p»tE«at««nt and 60-day
poit-tcvaticnt.
Occapatlonally-«ipoo*d patlccta in
Billco.
BtTkL POISOIIIS; HtftBOLITES; LZ1D
coisoino; cioos; icfoiimc KIDS;
tEHCILllBIIC: OCCOPITIOHL UZHDS:
»IT»t5: 8BIICO; LEID
a) 158 of 56* Kith cd !•*•!• of <
than 1 ag/1
t| 76 of 20« «i.th Cd l«wlB cf > 1
ag/1
tppeox 1:10 catlo of Cd to PI
thcoaghoat caag* of valiws.
Inpatlcnt* tt 7 Barlon Cogntj,
Indiana hospitali* and th* Icdiana
OniTvrslty Radical C«nt«c.
Indianapolii, Ind.
CIOIHOH: teto; miit; anus; iroiui
a) Bcfon Ca-EDTl adainlitcation
•9-rc-old caaalcal plant nortec (1966
to 19751 cspond to cds, Ml«nld«
dait, cce«nlng
ciogcaa at J.F. Kennedy Inetitnte in
1972.
LUD; LlaD POISOIIIO; BBTILS; IRal
(CISOIIIG: COIPtliTXTE BTkLOWIOISi
iiBTiaio: BiisoBiatn IETBODS
a) Occupational e«to»re
t) lo knocn cxpoiate
adalte fro* Brisbane, toatcalla.
HETU.S; ClORIOR) 1UD; (IDIEIS:
OtIIB: OCCOPITXOIU HltllOSi
tISTIkllt: COBPIBITITB BTalOWIOIS
BEFEBERCE
Holina-Balleiteros, 1.
Zaniga-Charlei, B. ».
Sanchez-inxaldo, r.J.
Gonzales-Baeicex, J.D.
1978
Lenis. s.c.
rorney, B.B.
1976
Lerner, S.
Boxlan. B.C.
1979
Chleole, J.J.. Jr.
Barrett. R.B.
Rarrleon, H.T.
1975
Riller. C.J.
•ylie. a.J.
BcXeonn, D.
1976
U)
N)
-------
L»d
7139-92-1
l» 207.2, BP 327.* C. tt 17M C. »P 1.77 •• Hg at 1000 C, 1 »• Hg at 970 C, 10 •• flg »t 1160 C
(COIIIIOED)
TZSSOB
2558
Orlne
2559
Orine
256 0
Orlne
2561
Orlne
MF030IB IOOTB
Ingest ion
Ingestion
HILTTICIL
BBTBOD
tts
DlthiZOD*
•OH BBS
OP CiSBS
7
1
i
9
BUGS
•) 70-»30 ag/1
b) 80-183 ng/2» kc
•1 lot applicable
b) lot applicabl*
c) Bat appllcalble
d) lot applicable
lot applicable
lot 9! ran
(BEIT
Ull
a) 251. 25 «g/l
b) 292.25 09/2* he
a) 110 09/1
b| «00 ag/1
c) 102 ng/1
d) 260 ag/1
»-72 og/2» hr
0.06 ppa vet «t
PUGEI
GIEEML IIFOB11TIOI
111 ca«e* iboMd clinical ilgn* of
lead pol«ODlD9.
El[loreea of •bip-iceekinf j«rd In
Gotebocg, Ileden. for 6 »k-2C yr,
aged 26-66 it.
lelgat lou. abdoalnal pain,
conitipatlon and/or dlaccaea,
(atigne. ccaips, toaitlng
BITilSi LB*0; BIOOO; OH IB; UOLTS;
CCCOP1TIOI1L laSlltS; CaSB BISTOBIBS;
SIBDBI
a) Tine of adilsnlcn
b| 20 loBthi after adniaaion
c) 28 nonthn after adaiulon
dl 16 nontbc after adnluion
(andon urine lead concentration*.
Black vonan aged a6 yc froe Jeraey
City. U
Polae rate of 106/nin. grade II/TI
ald«r*tollc ejectlcn narner. grand
aal celxgce
Iceaia, encenkalopatky. lead
nepkropathy, iltiligo and
kyperpigneotation of gnu. pale
conjectiie, atern< enlarged »lth
(ibroaronata.
ll>0; IIOI; BBTltS; BLOOD; BIOOD
SIIOB; IBID POISOIIIG; MBBI1; IBI
JIBSET; IBOB0100IC lUIIPBSTaXIOIS;
KBfOOS STSTIR DISBtSBS; OBIIB
Patient aged 2« liiing In Britain had
purchased aphrodiiiace fron
Kngladeib.
constlpaticn. precordial paic,
generalleed pain, colicky loin pain,
naaaea, and voniting
Intestinal liens sideroblastlc aneeia
LfiO; 9BT1LS; LE(D POISOIIIO; OBITBD
KIIOBOl; BIOOD; ORIIE; BLOOD SH8UB
snple< team aitopales fros the
Cincinnati area (1969-1971) cf «6
•bite eales, aged 20-D« yr. 19
trauaatlc deaths, 6 deaths doe to
drugs or carton aonoxide, 21 deaths
HID; 1-TH.S; BOIBS; IDIPOSB TISSO':
OBIIE; BOSCltS; II1BSTIIBS; KBIRT:
SKtl; BLIDDBB; STOBICH; BBIII;
IfSTtS; TBTIOtD GLIIDS; PIOSUTB;
I1OOO; IDREIIL CHIOS; LDIGS; SPLBtl;
PIICIBI5; KIDIETS; tITEB; lOPTt;
IDTOPSIES; OHIO; BIOICCOBOLIIIOH
lETEIEICB
Craner, K.
Coyer, s. t.
Jagenborg, I.
Vilsoa, B.8.
197*
ledeen, B.p.
Balllk, O.K.
Batnnan* T.
Bogdan, J.D.
1978
Brearley, 8.1.
Forsythe, I. a.
1978
Gross, S.B.
Pfitzsr, E.I.
Taagar, D.I.
Kehoe, B.I.
197S
U)
N3
Ul
-------
lead
7 « 39-92-1
BP 327.« C. BP 17(0 C, »P 1.77 ni Hg at 1000 C. 1 >• Hg at 0-0 C. 10 •• Kg at 11SO C
(COITIIQKD)
TISS1J
2562
Urine
2563
Orine
256*
Orine
2565
Orine
2566
Orlne
fTPOSOBF 100T«
tllLTTIClL
HETHOD
Dlthltone
US
ats
or cis^s
a) 23
b| «2
c| 35
d) 23
25
87
22
'""
al lot given
b) lot given
c) Hot given
d) lot given
aa-33« ug/1
lot given
a) lot given
b) lot given
1EII
a) 395 » or - 71 ng/1
b) 251 » or - 106
ag/1
c) 100.6 • or - *1
ug/1
dl 92 > or - 34 ug/1
. -
103.36 ng/1
3.»2 » or - 2.77
ug/100 al
a) 5. 5 » or - «.0
09/100 al
b) a. 9 » or - 2.1
09/100 al
6EIEBIL TIFOBBITIOI
a) Pb-poisoned >ock
-------
L«ad
7*39-92-1
Pb
Itl 201.2, IP 327.* C, BP 17*0 C, TP 1.77 » 19 at 1000 C, 1 •• 89 at 970 C, 10 » 89 «t 1160 C
(COITIIUBD)
TISSOB
2567
Drln«
2568
OrlB*
2569
Ocln*
2570
Orin*
BXPOSOIB IOOTB
tinmen.
BETBOO
US
us
1PDC-4XBK
US
BOBBEB
OP CIS8S
a
•1 36
b) *8
15
a
IIKB
a) «3-*7» 09/day
b) 530-5200 a9/day
a) lot givan
b) lot given
6-31 H9/>1
0.0 7-1. B2 aaol/1
BBII
a| 159.1 ng/4»7
b) 20*9. « ag/a>7
a) 0.3« uaoX««/l
b| 0.27 mol»/l
15.32 ng/.l
0.«2 aiol/1
6BIIU1 ZIPOIIinOI
a) 2*-ac arln«« b«(o£« eh«l*tloa
b| l«t»r 2 s 19 AOMI of CaBCTl II
B-12 he apart. 2«-hr acla«a-
D«tall«d clcacaoc* data pr«««nt«d foe
1 «lth Pb naphcopatar.
Ib «ock«ca cbocaa foe Btalr tftar
«ccMBla9 t*at> «a99«at«d aicaialT*
body burdens of Pb. I«o hoi (it allied
•1th laad colic. l«ad axpoatr*: 3-6
jr. kg»m 28-50 ir.
l*o sgbjicta: l«»d colic
3 aabjacta: pcaellaleal Pb
aaphropatby, pcoslcal tabal*
•taocialltlai.
1110; BBtltS; BETH POISOIXIC: LE4D
SCISOIIIO; BIOOD; 01111; OCCOPaTIOIlL
BltklDSl BIIIB1L IRUOUSI
a) Cacdlo*aacalar patient*
b) locaotanalM pa Hants
latcaindiTldnal Tarlatlon.
Batlanta iltk aodacata to *aMC«
cicdiac coBditiom and/or
h}p*cteoaloQ. CoDtrola »ith ao kaovn
cacdlovaacalac ara(toaa. all onr 30
yc old.
ItlUSi CkDBIOBl LBIDj CMDXCT1SCOUI
CI5USES; QIITBD KIMOOB;
BtPBlTMSIOl: aQI; IDOITS; SBOKIROj
CCIP1UTITB miHUTCIS; BlOCDl OIIBB
Bo appacaat dlffaranca* la calatioa
to tlaa, «•», oc «9«.
Oaatpoaad folaata«ca «9«a, 20-5* yr.
Bit US; CID1I09; LE1D; ORIII;
BItSDIBBBBT IBTHODS; kOB; SB1;
CCIPtllTItl BfalOITIOBSi BEI TOIK
Lead vockcca, 21-63 yr old, t*in9
diagooaad aad tcaatad foe laid
Falaonlng.
BRlLS; LEIDl BIOOD; OBIIEj
CCB?a«ITIVE t»»tO»TIO«S; LEIC
IOI30IIIO: JaPlli OCCOPMIOBIL
BIZIBDS
BEFEBBICE
fadaan, I.P.
Baaaaka. J.K.
lalnac. B.
Lipat. o.».
Lyona, B.B.
vital*, t.r.
Jooalon, a. 8.
1975
(haca. 1. IE.
llbbarlay. D.G.
Ed«acda. K.I.
laldcon, 1.4.
1990
Lagotta, P.I.
Soaa, I.e.
Satton, D.c.
1980
tcakl, S.
1980
LO
to
-------
Llthlua
•U39-91-2
li
»tv 6,'al,
I!? 1S0.50 <~ , K? 1216 C, VP 1 ,• Hg at ""21 r, 10 •• H<3 at D90
TTSiTE
T'l
9lOO'l,
plasaa
2V2
Blool,
•era*
2573
Blood,
SBCBB
257*
Blood.
•eras
BTPOSOP* 30UTE
Ingest Ion
,
Tngeitlon
Ingestlon
UmLYTICtL
1ETHOD
MS
MS
HtUB'S
OF CUSES
e
s
11
1
SMIGE
al lot given
b) Hot givan
b) O.«0-0.«5 BEg/1
c) 0.05-1.52 aEg/1
0.2-1.75 Beg/1
0.7-1.0 MOlM/1
(IBXT
1*»»
11 0.675 • or - 0.03J
nal/1
b) 0. 6?» » or - 0.0«2
MDl/1
b| lot given
cl lot gliea
Rot given
lot gl»«n
P»GB)
r.tumi uromitTioi
a) J. 1 • or - 0.36 he aftvr SCO ig Li
Ion in Lithlcacb (standard tablet!)
b) 3. 5 » or - 0.«7 be aft«r 800 ig Li
Icn in Priadel (slow release
Peak seans
Cocvvs ovec 8 hr suggest equlvaLent
bloavallabilltr of the drags.
B«lthy 'oUnteera, 20-23 yc old,
••.5-92.7 kg.
DlOaS; 0900 TBEB1PI; LITBIOB;
«IT»BOLISB: BLOOD PLASH; OB1IE;
COBPmiTITE EULDlTIOHSj
iniDEPBISSITE IGEITS; 1DSTBU.II
Li carbonate 3 tiees pec day
(•0 sg/dar)
c) Dating 2-nk tceatcent >itb 300 19
11 3 tiles pec dar plus
hvdcochlorothlazlde (50 sg/darl
Fang* oC aeans.
6 healthv folODteeca (5 >en and 1
sosan) ages 2«-«0 jc
Slight tceaocs, concentcatioo
diCClcelties and ptychotcoplc effects
aftec lithlus alone in sone.
Pclyucla, thirst, tiredness, nausea,
and concentration, speech and vision
ccobless after lithiai and
focosesid*. Thirst and concentration
problees in a fee subjects after
llthini and hYdcoehlorothiazlde.
CFDQS; PSTCHOTBOPIC DBOQS; BIOOO
SHOD: LITRIOBi BEllLS; (ISCCBSII
Bange, d«y» 2-7, patients on varying
dosvs Li2C03 for 10 day*. Sean drop
in seme thvroxlne-X after 10 days
BBS 3.83 ng/dl.
Patients ulth thrcotoilcosls.
Tceior, nansea t voiltlng. dlfficalty
In accOBBOdation.
IITHIIIR: Dimaai; BOHBOIES; nssisES;
CCBPHaTHE ETaLOltlOfS; DBOSS
300 sg L12C03 at/day and S ag/dav
halopecidol.
26-fc-old fasale suffering frOB
aania. Jglj 1978.
Ifter 5 BO OB L12C03: >eakn«ss and
(atigae followed by gai bleeding and
epistasls. Develocsent of acute
Bonocytic leakBBia.
It 5 aonths: «hite-cell coBnt
382.000, «ith Bonoblast sorphology.
LIIBIOB; IBB TODS SISTBB DISItSBS;
BLOOD SBBOB; LBOKBBIa; HBT1LS; BBHTB
BIltlDS; BBQPHSBS; C»SE IIS10IIBS
BETEHEUCH
Johnson, G.
Hunt, c.
Jackson, D.
Dichards, T.
197Q
Kalin. I.X.
1979
Kristenaen, 0.
andersen, H.8.
Pallisgaard. G.
1976
Baiaond, I. p.. IT
tppelbana, r.
1980
u>
(S3
00
-------
UtUM
7*39-93-2
11
»tl 6.9»1, If 180.5* C, BP 1336 C. TP 1 •• 19 at 723 C, 10 aa Bg at 890 C
TXS50B
2575
Hair
2576
Udner
2577
LlT«r
'
BIPOSOBB BOOTI
aiainxcai
BBTROD
PaotOMtty
BS
BS
IORBBI
OF C1SBS
at 179
b) 108
cl 102
4) 109
I1IOE
•) lot gi»en
b) lot gi»e«
c| lot glTen
4) lot glTm
a) lot given
b) lot given
c) lot given
a) lot given
b) lot given
c) lot given
(ttrc
•III
•I o.o* ng/g
b) 0.05 «g/g
el 0.0* ag/g
A) 0.05 ag/g
S«o»tric iiaD«
a) 76.0 ppa (I3S)
b) 83.0 ppi (32«)
c) 89.8 pp» (16*1
._.
a) 79.2 pp« («2«)
b| SI. 6 pp» (27*)
c) 57.5 ppi (16*)
?»OB|
GBiniL moiuTioi
a) Hal* chlldran
t) F«aal* children
c| aal« adolta
4) ?•••!• a4olta
CocnlatloD t«t«««n LI »nd a«.
!44ttioMl 4ata.
Scalp bale, caacaiiaoa In IT, agva <1
to gr«at»r than 51 jr.
BIIU.S; T»CB HIIBITSi B»8ttB;
E010I; CaOBIOli CBBOBTOR; COIPEI:
HOI: LBaD; IRHXOBi HUOtlBiBi
SIICTII; IXCIU; SILBIIOB; SILTBB;
Till TalaOXOHi IIICJ BtIBi ACB;
ICDLTS; CHI1DIBI; SBX; COHPafinTB
BTatOlTIOIS; DOSTi SOUS: 1X1
POLLOIIOI; OIBII IBIaS; IB! 10BR
a) lo caaal dis«aa«
b) lent* renal (allacca
c) Chronic canal (allures
Cry *t ba>la
taccvat of a»pl«« lith detectable
l«»el« i« indicated In par«nthe
N3
VO
-------
lithium
7(39-91-2
Itl S.9al. IP 180.5* C, BP 1336 C, »P 1 •> Rg at 723 r. 10 » 119 at 190 C
(COITHOEO)
Tissue
Kit
Splwn
J57»
0cln«
EIPOStJBB B00TB
Xngestion
MII.YTICH.
1ETBOO
ES
US
BOBBEB
OF OSES
8
B1IGE
..
•) lot glTen
b| lot giTBB
C) lot glTBU
» lot given
b) lot gif«n
mi
«l 15.6 ppl (13%)
b) 85.9 ppi (211}
C) 70.8 pp. (U'.|
•I 5*. 9*
b) 51. 7%
Gtimi IIPOlltTIOl
c| Chronic r«nal Cailarea
Ccr «t bail*
F«tc«nt of aa>pl«« oltk d«t«rt«bl»
1 1> lDdic«totop«l«> it OCU Roipltal.
TB1CE ELBHBITSi (ETUS; »OTOPSIES;
CILIPOIItt; HIOIEIS; LITBB; SP18M;
CISElSJSi BTPCTTEIStOM; SOOIOB;
tonssma; ciLciua: pRospaoaos;
giQIESIOR; CIDBIOB: II 1C; COtPEI;
UiD; IIOI; UICIIESE: H.OHIIDB;
SIIICOI; TtTlimi; COB1LT; IICKBL;
[CLTBDEIOR: Til; CB10BIOB; S1IOITZOR;
BIBIOB; LITBIDR; SILTBB; »H IDIOT J
EOIOI
•) Eicr«t«d daring 2* he aft«r 800 ig
11 loo in Llthicacb (standard
tablets)
t) Excr*t«a daclna 2« he after 800 19
Li ion in Ptiadal (ilov c •!••>•
cnparatlonl
Doclnq tlr«t « hr 19. 7t «ict«t«d
aftac Lithlcacb. 13. i< after Pciadei
(t <0.001|.
BealtkT »olqnt««c», 20-23 yr old.
:». 5-92.7 kg.
Dims; DROO TBElaPI: LITBIOO;
ainaoLisB: Biooe Ptasia: OB IBB:
COBPalaTIVB ITtLOlTIOISi
IBTIDBPIBSSIVB tCEITS; iOSTBU.Il
BEFEIEBCE
Indrapcasit, s.
tletander, 5.T.
Gonick, R.C.
197«
Joknaon* C.
Rant, a.
Jackson, D.
Richards, T.
K«an, E.
1979
U>
Co
O
-------
acid (lo posting* ID CRERtxni.
TISSUE
2580
OCiM
BXFOSOIB BOOTH
Infection
IMLTTICII.
BBTBOD
SC
BOBBBB
or CMBS
%
HIGB
•) 9.0-25. B 19/2* be
b) »0. 5-77.0 19/2* be
9BII
•1 1«.» «g/2» be
b) 59. • ig/2* be
CBIB11L inOBBiTXOI
-
•I studied 4c*9 fecnlktlon
t) D«l*T«d BbaocptloB tablet!
Doug* 2.5-3.5 9/d«T l«*odop*.
! ••!• and 2 t«aal« packiMOclan
pitUatc aged 61-6B yr.
Ca«tcolat«»ttnal ilda •fftct* «lth
delayed celease foe*.
DBOOS) RBTtBOLItBS; OlIIBi DHTBD
IXISDOB
BirSUBCB
SandUe, B.
latbraii. C.I.J.
Coodiin, B.I.
BHtee, K.I.
st»e». a. a.
197*
OJ
co
-------
a-Tolnlc acid, alpha.1-diacetaaldo-2.a.6-trli.o4o- (8 CI)
Beaxolc add. 3-(aeetyla»lnol-5-Uacel7lanino|aathyll-2,a.«-trllodo- (9 CI)
MO-5B-*
Ct2-B11-I3-»2-0»
HI S27.«J. St 25S-JS7 C
TISSUE
2581
Blood.
plaaaa
258J
Oc in*
._
RXPOSOBE ROUTE
loj«ctloB
Injection
-
mi. men.
RETROD
IOHBEB
or cists
al 3
bl 3
CI •
4) 2
el «
f) 2
«1 5
7
BtlGB
a) 255-13.7 agX
bl 1»S-»1 igt
cl 255-«7 agX
d) 215-65 «gt
•1 (60-26 »gt
f| 600-320 agX
gl aiO-150 agX
a) Rot given
b) Rot given
REtR
a) ot applicable
b) ot applicable
c| ot applicable
d| ot applicable
e| ot applicable
f) ot applicable
g) lot applicable
a) 9M of dose
b) 911 of doae
GEIEIIL IlrORRlTIOR
•) 2.5 and 210 aln after 2«.'5 9 in 5
ala to healthy ealea
r) 2.5 and 2«0 lin after 9.9 g In 2
•in to renally iapaired
c) 2.5 and <60 (in after 1«. t g In *
•in to renally lepaired
d) 2.S and «80 iln after 29.7 9 in 6
a in to renally impaired
e| 2.5 and 210 »in after 61.8 g in 23
a in to healthy iale*
t| 2.5 and 240 *in after 83.2 g in 16
•in to renally impaired
91 2.5 and 2*0 aln after 56.2 g in 19
ain» to renally inpaired
CCRP1BHIVE EML01TIOIS; BLOCD
PUSH I i OBIIE; PEC IS; DODOS
a) Pleat 1 he. healthy aalei
b) 72 hr. healthy aalea
Data incomplete for patlenta vlth
renal inpaiceent bat aoet of doae
excreted in urine, loraal aabjecta
excreted aoat of doae «• unchanged
icdaiide.
ccnrtBttiTE nnoiTiois; BLOCD
fUSRl; ORIRt: PEC IS; DEOG3
BBPEBEKCE
Dirazio. L.T.
Singhrl, S. R.
Heald, ».P.
HcXlnatry, D.»,
Brosun. S.I.
Glllennater, J.T.
Illlard, D. ».
1978
t
DiPazlo. L.T.
Singh*!, s. R.
Heald, 1. P.
HcKinatry, D.R.
Broeun, S.I.
Olllenirater. J.T.
(illard, D.I.
1978
u>
-------
B-TrroBlao. I- (8 CX) (TIB)
t-n»ruiuiM. 3-ky4ro«r- i» a
5(7-33-7
C9-B11-B-03
It 181.19, HP 267-270 C (docoap)
nssoi —
2583
Blood.
plBBBB
2S8«
BrlBB
- -
BDOSOIB BOOTS
TngcBtlon
XBgostloB
tiumciL
BBTBOD
OC
OC/RS
-
BOBBBB
OF CUBS
2
2
B1IQE
3-9 UOlM/I
2C-105X of do»»
ran
lot gi«n
65. 5X of dos*
GEIEIIL IirOIHlTIOl
0.3-1.0 hr ««t«r S ig/kg. P«tk.
0.3-0.5 he
(••Itky adalta ••intalavd OB Bilk end
••tor ilic* pr»»ioo« S»j.
IBIIO kCIDSi BET1BOIISB; BBTUOUTBSi
BtCOD ntSBIi OI1II; QBRBD IXBQDOB
Iierotod B« B-hTdcozTpkoBjlBeotle
•eld IB 8-kc BTlMi. 5 Bg/kg doBB.
B-BTdroKTBBBdollc add «nd
3.l-dlkTdco
-------
7«39-95-«
RQ
Itl 21.309, IP 651 C, BP 1100 C. T* 1 » If at 621 C. 10 » 89 at 7»o C
TTSSOB
25«5
Blood
2586
Blood
2587
Blood.
plaaaa
25*11
Blood.
aaraa
25B9
Blood.
MCBB
EIPOS05B BOOTE
*
-
Injactlon
HiLTTiciL
RBTROD
us
colorlaatrr
•
US
*OBB!I
or CISBS
72
al 1
bl 10
187
BtlCS
a| lot glTan
b) lot gl*an
c) lot glran
d) lot glT«n
•) lot glvan
f) lot glTan
a) 1.56-1.91 aaq/1
b| «.2-3.6 aaq/1
-
a) lot gi'an
b) lot glTan
(IIR
till
al .53 ag/100 al
b) .65 ag/100 al
c| .69 ag/100 al
d| .77 ag/100 al
a) .76 ag/100 al
fl .73 ag/100 al
.
al lot glran
bl lot glTan
al 2.« ag/100 al
b) 2.5 ag/100 al
P»OE)
GEIEI1L IirOIBATIOl
a) Mood froa 22 acthaca, lot birth
«t gcoap (1500-2500 g)
c| Blood fcoa 50 Bcthara, noraal
tlrth «t group (>2500 g)
c) Blood fcoa 22 aothara, noraal
tlrth «t grcap Batckad «ith JOB birth
at gcoap for MX, aatarnal aga, raca.
aaoklng habits, parity
d) Cord blocd froa 22 aothar*. low
blcth at grcap
•1 Cord blood froa 50 aothaci, Boraal
birth at gcoap
() Cord blood froa 22 aothar*, noraal
blcth «t gcoap aatchad vith low birth
• t gcoap foe MX, aatacnal aga, raca.
aaoklag hablta, parity .
Bothara who gara blcth in laurk, IJ,
Iprll-saptaabar. 1975.
IITILS: CllCIOB; CBBORIDH; CCPPES;
IIOI; RlOIBSIDR; SIK; BLOOD: » DOLTS;
PtIOS; III JIBSET; COHPlBlTItB
ETllOkTIOIS
lailaw
HITtLS; COPPEB; IIOI; R1GIESHJH;
•IIICalESB; IIIC; BRaLLOPBOTEIlS;
IIEOR1TOID IIIRIITIS; IETIBI
a| langa of iBcraaantal-Rg 0.75-3.75
hr aftar 16. « aaq IT at start of 1.12
al/aln Infaalon of 2.5S RgSOi
taptakrdrata. lonpcagnant aoaaa with
laloayoaaa
b| 0.25- and 5- he aaana aftcc a doaa
of 2«.6 aag IT vith 82.* aag IR to
aclaaptic noaan. Pa«k aaan. «.5
••g/1. at 1-2 hr
Cata on ••eras* and Rg spacai.
RRILS; RkOIISIOR; PBBGUICt ;
CCBPiBITITE ETtlOtllOIS; HEIIDIBBBIT
BRRODS
laTlaa
B1GIBSIOH; IE1D; UK; BBTaLfi TRICE
BtERBITS; DlinilB IITIt; BLCOD;
BIOOD SEIOB; IE1IT; BOIES; OITTBD
(IIQDOH; CII1DI; OIITEO STITES;
riiikiD
•I Ran
b) loaan
Criteria Cor low lafala < 1.6 ag/100
•1.
lacal Dtahna. SB aan, 129 woaaa, a«an
ag« 69 jt.
DIETS; tlaCI BLEIZKS: CROLBiTEtOLS;
BLOOD SBIOB; IIIC; COPPRl PCTtSSIOR;
SODIOR; R1SIESIOR) CkLCZOB: HOI;
TITalll k; TXTkBKS
lifEBEICB
Bogdan, J.O.
Thlnd, I.S.
Kaap, T.I.
Cataclni, H.
19'e
Soranaon, J.B. J.
1978
Chaalay. I.e.
1979
Sharcatt. k.B.
1977
riahac, s.
Randclcka. D.G.
Rakonar, l.l.
1978
-------
•agasslas
7a39-95-a
lt» 2«.30S. 17 651 C. BF 1100 C. »P 1 en 89 at 621 C. 10 •• 89 it 7*0 C
(COITIIOID)
TXSSn
2590
Blood,
•Oraa
2591
Blood,
serae
2592
Blooa.
soraa
2S93
Blood.
sera a
BIPOSOIE BOB1B
Ingestloa
Infection
Inge at Ion
II1LTTXCII.
BBTBOO
iii
us
us
US
101 BH
OF C1SBS
•I 16
b) 16
C| 9
a
I) 80
b) 72
2*
BIIBB
•1 1.98-1. 85 sg/dl
b| 1.72-1.81 sg/dl
c) 2.05-2.13 ag/dl
1.90-1.97 09/100 al
a) 1.5-2.5 (9/100 .1
b) 1.5-2.5 19/100 al
•1 lot given
b) lot gl?«n
c) lot given
d) lot given
•I lot glTon
f) lot given
mi
•) lot applicable
b) lot applicable
c) lot applicable
lot given
a) 1.96 » or - 0.19
•9/100 al
b) 2.00 • or - 0.19
ng/100 al
a) 15.6 oq/al
b) 15.1 ag/el
c) 15.5 ag/al
d) la.i og/el
e) 15.0 aq/al
(I 16.9 09/1!
Gimii xiFOBiatxoi
•) Control, 2 and 6 he after SO ag
In. Fa«tlB9 »alae, 1.92 «9/dl
b| Clcchotlc.O and « he after 50 19
tt. Flaal «•!••. 1.77 «9/dl at 6 hr
c) »o«ta«r9lcal grogp, 0 and » kr
atter SO 19 la. Flaal »alae. 2.07
•9/dl at 6 ar
111 gcoQRi (asted before In.
Coatrola. patient* «lth alcobollc
clrrko«l«, poMncglcil pat lota vlth
delayed keallog.
IIIC; CTBIBOSISl OIXIB; BLOOt;
IIBBISM: IBST TIiellTI; SOICtll;
CHCIOB: IICBBSIOB; COPFBI; 1BICB
B1BHITS; DIOBS; BBTI1S; LI»t«;
CISBISES
Bean Talae* all greapa daring *
eiperloental perloda of • 4aj« each.
Sobjecte received ai9.78
|ai3.9S-«2«.93| ag Ig/dar «ltb basal
diet or elth taaal diet ploe 1».2
g/dar aappleaent cellnloae,
keileellaloae or pectin. Saall
eicretlon doe to extra fiber,
elgnlfleant changea la fecal aloeral
Icee.
laalthy adoleaceat boya
BRIIS; TIICB ELBSBIIS; RIIBIILS;
CCFPBB; IIIC; HlGIESTHBj BLOCO SBIDR;
OIIIB; FICBS; IDOLBSCBITSs FIBKiS;
CCHPIIITITt ITllOITIOIS: IBBFISU
a) Idoleaeeat glcla. 19^6
b) Idolesrant glcla, 1977
Intakea, deterelDed by dietary
recall, belon BD1 bat sufficient to
•aiataln balance, all level i In
aoraal range.
•dolescent girls, lean age of 13.3 yr
in a) and 1«.5 yr In b) .
ICOLISCBITS: BLOOD; BETUS; UICB
HBIBITS
a) 1-3 ao lactation
b) a-6 eo lactation
c) 7-9 ao lactation
d) 10-15 ao lactation
e| 16-21 ao lactation
() 22-31 ao lactation
tblt* voi«n, 1-31 BO postpartaB.
HOOD SBIDR; 81 Lit ! Bill; BET US:
IICTITIOI; CILCIDR; lUGIESIOt;
BIIOIIBSB; IIOI: CCPPEI; tilt
BBFBIEICB
Salllvan, d.F.
Jettoa, H.B.
Barck. s.B.
1979
Dram. L.H.
Ues, c.
Fox. R.a.
1979
Greger. J.L.
Graoer. S.I.
Etbyre, G.B.
Ibernatky. B.P.
Sickles. ».
197»
Taagkan. L.I.
Veber, C.I.
Koeberllag, S.B.
1979
CO
-------
RagnesUe
7«»-95-»
Itl 2».305, HP 651 C. 8P 1100 C, If 1 •• Hi It 621 C, 10 •• Rg at "'00 C
(COITHUED)
TISSOE
2S9»
H«lr
2S95
Heart
2*16
2W
Line
2599
lung
RXPOSORB IODTE
- - -
IIILTTICIL
HrrHoo
us
ES
ES
BS
BOHBTB
or ctsss
e
a) 13*
b| 7ft
c| 16
a| 91
b) «2
cl •»«
30
BHIGE
a) lot given
b) lot alven
c) Hot given
d) lot given
•) Hot given
a) lot given
c) lot given
a) lot given
b| lot given
e) lot given
11.5-1B6.0 ng/g dry vt
(IE»I
a) 37 ppi
bl 28 ppe
c) 22 ppe
d) it ppn
e) 61 ppn
al 60^ ppe
e| 559 ppn
a) «99 ppa
b) SCI ppn
e) 559 ppn
lot given
GEIEBIL ZirOPDlTIOl
a) 1-6 no lactation
bl 7-9 no Inctation
c) 10-15 no lactation
d| 16-21 10 lactation
e| 22-31 no lactation
Hbite vonen, 1-31 no pontpactnn.
HOOD SEBOB: BIL«; Bill; BBTILS;
iicttTioi: cuctoi; aiciEsiot;
tllGtIBSE; IBOI; CCPPBB; ZIIC
levle*
BIGIESTOH; HID; ZIIC; BETtLS; TKICE
IIMEIT5; OtIIKIIG I»EB; BLCOD;
BtOOD SE10B; BB1BT; BOIES; DIITED
milDOK; ClItDl; DIITEO ST1TIS;
TIlltlD
a| lo cenal dineaee
c) Chronic cenal (allures
Dtv lit baein.
Igtopslea at DC LI Hospital.
TI»CE ElEBEITS; BEI1LS; tOTOtSIBS;
CILIFOBIH; II01ETS; IIVE1; SPLEEI;
CISEtSES; RTPBBTEISIOI; SODICB;
POIISSIOB; CtlCIOl; CHOSPHOBtS;
BIGIE5IOR; CIDIXDR; ZIIC; COtPEK;
1»D; IBOI; BtlOtllSE: aLOmiOR;
SILTCOl: TITUIOHl COBH.T; IICKEL;
BOLTBDBIOR; Til: CRIOHIOR; snORIOB;
BJIIOH: IITBIOB: SI1TBI; T1UDIOT1:
BCIOI
a) lo cennl disease
t| Icate cennl failures
c| Chronic cennl fnilnres
Cry vt basis.
Intopsles at OCU Bospltal.
TltCE BtEBEITS; RETaLS; tOTOISIES:
ciLiroBiti: HOISTS; LITBI; JPLBBI;
DISBISES; ITPUfEISIOl; SODXOH;
FOTtSSIOR; C1ICXOH; (HOSPROIDS;
BIBIBSIOH; CIDBIOR; ZIICJ CO IP El!
LHD; IBOI; RtlOtllSB; HOHITCH;
SILTCOl; TITlIIOB: COBtLT; IICIBL;
BOITBDEIOB; Tilt C BIOS I OB; SlBOtTIOB;
BIIIOR; IITBIOB; SILVER; TlllDIOB;
BCBOI
Sections of lungs (con subjects nho
had been bitnnlnous coal sinus (or
23-50 yr.
Bit ItS; TSaCt BLEHERS: ILDBIWOR;
IIIIOR; BEBTUIOR; BOB 01 1 CRBOHIOH;
COPPBt; 6EBHIIIDI; IBOB; LElt;
BISIBSIOH; HMGaBBSB; IICKBL;
siLicoi; siL*n: txi; tmiioa;
flllOIOH: LOMS; COIL; OIITBC ST1TBS:
OOUTt; RIIII1LS
BErEJEICE
vaughan* L.i.
(eber. C.«.
Renbecling, S. P.
1919
Sharcett, k.P.
1977
lodrapraait, s.
Gonlck, B.C.
19f»
Indcnprasit* s.
alezandec, G.V.
Bonick, R.c.
197*
Ccable. J.v.
(eenan, B.C.
lolovicz, p.R.
Knott. R.J.
Bolts, J.L.
corski. C.R.
1967
U)
(IEIT PiGEI
-------
Bagaaalaa
R9
111 21.305.
651 C, BP 1100 C. TP 1 u Ig it 621 C. 10 •• Bg at 7*0 C
(COITIIOED)
TISSUE
2599
Ling
2600
Lang
2601
Lang
2602
lyaph
nod*
2603
Rllk
— _ — —
IHOSOBB BOOTS
'--
aEaLTTICll
RETBOD
US
US
us
us
us
IORBEE
OF C1SBS
20
a) 129
b) 15
13*
al 26
b) 3«
c) 23
d) 13
•) 28
f( 30
B1IGE
lot glTan
a) 0.13-0.62 ag/g dcy it
b) lot giran
0.43-0.62 ag/g dcy at
,
lot giran
a) lot glfan
b) lot given
c) lot givan
d) lot givan
a) lot givan
f) lot givan
(•BIT
Bill
5*3.0 ag/100 g dcy it
a) 0.52 ag/g dcy at
b) 0.38 ag/g dcy it
0.53 ag/g dcy "t
1303.0 ag/100 9 dcy
it
a) 31 • oc - 1.7
ug/al
b| 31 » oc - 2.7
ug/al
cl 26 • oc - 3.3
ug/al
a) 30 t oc - a.t
f) 26 » oc - 5.1
ug/al
PIGE)
CBIEIIL IIPOBHHIOB
Incladaa appar aid loiar lobaa, and
lyapb nodaa of lang. additional data
availabla.
sactlona of lunga fcoa mbjacts iho
aid baan bitaainoua coal alaaca foe
12-50 yc in lalaigb County, last
Ticglnia.
BITU.S; TliCB BLBRERSi COIL;
BIBYLlIOfl; COB41I; CBBOBIDB: COPPBB;
HOB; LE4V; B1GBESIOR; S1IG4IBSB;
ITCKBL; THUMB; UIIOIOB; tIBC;
lOIOSt COHP4B1TITB BUL01TIOBS;
SILXC4: 001BTI; IIBPH IODES; IEST
a) Coal ainaca
b) Control!
Sactlona of langa fcoa dacaa*ad coal
ainaca and non-coal alaaca fcoa
lalalgh County. IT.
BBTUS; TBICI E1IHEBTS: COIL; SIUC1;
I1BTLLXOR; CBBOBIOfl; COPPSBs IIOEs
HID; RkOIBSIOHi ntlOtlESE; EXCRL;
Ultima; TllaOXOH; II 1C; LOWS;
CCRP4B1TXTB BT1LU4TXOE3; IES1
VIBGXBX4
langa of aaana. Iddltlonal data
availabla.
Ticglnia bitaalnona coal ainac*.
BMALS; TIICC E1EHBRS; COIL; SILIC1;
BIBtLtlOB; CBBOMOB; COPPEB; IBOI;
ItIO; S4GIES10B; HklGllBSB; BICKBl:
TITIIIOB; TII10I01; tllC; IOBGS:
CCBP4UTIVB ETI1011IOIS; IES1
lIBGIlIt
Palaonacy bilac lyaph nodaa (coa
aubjacts abo had baan bitnaloous coal
ainaca foe 12-50 yc in Ralalgh. vast
Tlcginla.
8ITILS; TB1CC ElBRBRSl COIL;
IIITLUOI: COBlLT; CRBQBIOR; COPPBB;
IIOI; LElD; BIGIESIOB: RtlGIIBSB;
IICKBL; TITIIIOR; ftUDIOR; IIIC;
IOIGS: CORPIBiTITE BTtLOlTIOIS;
SILICl; QOtBTZ; 1TRPR IODES; VEST
tIBGIIU
a) 1-3 ao lactation
b) 1-6 ao lactation
c) 7-« ao lactation
d) 10-12 ao lactation
a) 11-18 ao lactation
(I 11-11 ao lactation
Ibita voaen. 19-*2 yc aga. 2]
pcialpaca* and 16 aultlpacaa.
MOOD SEIOD; RTLK; BETiLS; LKTtTIOl;
RUB; CklCIOR; HlGIBSIOR; BtlGtIESE;
IIOI; COPPtl; line
BBPEIBBCE
(taanaa, B.C.
Ccabla, J.T.
Saalliood. 4.1.
Caclbarg. J.B.
1971
Snaat, D.T.
Ccoaaa. I.E.
Crabla. J.T.
Caclbacg. J.B.
Lalnbact, w.s.
197*
Caclbacg. J.B.
Ccabla. J.T.
Liatlaca. 1. P.
Bolti. J.L.
Banac, p.
loloiicx, r.B.
1971
Kaanan, B.G.
Ccabla. J.T.
Saalliood. t.l.
Caclbacg. J.B.
1971
Vaughan, L. a.
Vabac, C.V.
Kaabacling. S.P.
U)
-------
Bigneslua
7»39-95-»
'?« 2«. 105. IP 6S1 C. BP HOC C. TP 1 » 09 at 621 C. 10 as Rg «t 710 C
(C01TII01D)
TISSUE
2«0«
Silk
2605
•all
2606
Spleen
2607
Teeth
EXPOSOEE BOOTE
.
UkLTTICIiL
HET80D
US
ia
ES
US
IDBBB1
OF OSES
a| 76
b| 77
cl 23
4) 78
e| 29
...
al 50
bl 50
c) 3»
4| 23
a) 90
b) 38
c) 76
35
BIRSE
~~
a) lot given
b) lot given
c| lot given
4) lot given
e) lot given
•I lot given
b) lot given
c) lot given
d) lot given
a) lot given
b) lot given
c) lot given
.
880-5720 ppa
BEal
al (0.38 ng/el
b) 31.65 ug/sl
cl 29.13 ug/al
d) 32.0 ug/sl
el 29.0 ug/sl
al 101.1 ug/g dry «t
b) 102.7 ug/g 4rr >t
c) 118. ? sg/g drr »t
d) 120.6 ug/g dry "I
a) 5*7 ppa
b) 515 ppe
cl 521 ppa
1650 pps
GEIEI1L TIFOIUTIOI
a) Coloatrua, high and lov iccose
groups
t) utter lactation 1-3 sontha. high
and lov incoae groups
c) tfter lactation > or • 13 eonths.
high and lov incose groups
41 Ifter lactation 1-3 sonths. loe
incose group
incose group
additional data available, to
significant difference betvetn ineoae
groups.
Icsen froa urban and rural Itdia.
RET1LS; TBtCE ELEBEtTSi COPPIB;
•10IESIOB; ZIIC; BILK; COBPaUTIVE
CtatOaTIOIS; OIBtl »BE»S; BOttt
tlias; IIEI1
a) Fathers
b| Bothers
c| Bale teenagers
dl Fesale teenagers
Values also given for sediana an4
geosetclc aeans.
50 Belanesian fasilles, aean age of
fathers, 16 jr, sothers, »1 jr. «3
aale children, 12-2* yr and 38 fesale
children, 12-2* yr.
CIICIOB; SODIOB; HaGIESIOB; ILOBIIOB;
SOLFOB; CBLOJIIB; ttHDIDIi
BUGIIESS; COPPEI; TlkCI BLB BEITS;
ftCOD PIESSOBE; IBI GO II El; SBTILS;
IIIU
a) Ho renal 4isease
b| Icute renal failures
c) Chronic renal failures
Dry «t basis.
autopsies at OCia Bospltal.
TIICE ELEBIITS; BBlaLS; kOTOfSIBS:
CILIFOBIIt; HIDIBTS; LIVEB; SPLBEB;
01 SEISES; BtPMTBISIOI; SODICB;
fCTlSSIOB; CIICIOB; PBOSPBOIDS;
BIOIBSIOB; CIDHXOBJ; fIKi COrPBB;
1I1D| IBOI; BIIStllSE; ILOntOB;
SHICOIt TRaBIOB; COB11T; BICIBL;
BCLTBDEIOB; TIB; CBBOBIOB; S1BOITIOB;
BIBIOB; IITBIOB; SILVEB; T»IIDIOB:
ICBOI
Caabrldge, Bk schoclchildren
IBiCB EtBBEITS; BEIkLS; STBOvTIOB;
lltO; SODIOB; BkGIESIOB: IIIC;
FIOOBIDE: BISSICBOSITCS: CBX1DIEI;
TIETI; 1BISOIBBBBT BETBODS
BEFEBEHCE
PajaUkshei. '•
Srikantia, S.G.
1980
Basironi, B.
Kolrtyohann, S.B.
Pierce, J.o.
Schaesehula, P-0.
1976
Indraprasit, S.
tleiasder, G.».
Gonlck, B.C.
197a
Brudevold, F.
led*, k.
tasenden, 1.
Bakhas, T.
1975
u>
00
(BEIT PlOB)
-------
Bagneslaa
7«39-95-«
•g
Uf 2a.305. IP 651 C. I? 1100 C, TP 1 •• Ig at 621 C. 10 •• Bg at 7*0 C
(COKIIOBDI
TISSUE
260S
orlae
2609
Orlae
2610
DrlM
2611
OrlOe
2612
Orlae
ElPOSOtl IOBTI
Ingeatlon
Injection
Ingeatlon
Ingeatlon
1I1LTTIC1L
BETBOD
us
us
colorlaetry
US
us
IOBBBB
or cisss
•1 •
b) 3
•1 16
b) 16
a| 1
bl 10
8
12
UKE
•) 95-167 eg/flay
b) B6-12« eg/day
•1 3.8-1.1 eg/hr
b) 3.5-«.e egAr
•) 23.3-47.5S
b) 9-52*
155.0-172.2 eg/day
-
•1 tat given
b) lot glvea
BUI
*) 128 eg/day
b) 105 ag/day
•) lot applicable
b) lot applicable
i) lot applicable
b) lot applicable
lot glvea
al m » or - 11
ag/day
b) 126 » or - 8
ag/day
CBIIML IIFOIliTIOl
a| Contcola, 32-36 ik pregaant,
ia«ntical 41«ts
b| 32-36 «k pregaaBt, 1 g/dai extra
calciaa
7 pcleaparaa. aged 16-19 jc
CILCIOBj BIOHSI08: PBOSPB0103;
BE1US) OIIII; ME8IIICI; DIETS;
lOSTtllla; COBHilTITB BT110ITIOIS
a) Control. 0 and 2« he aftec SO ag •
In
b) Cicckotle. 0 aaa 2* kr after 50 ag
It
111 (aatai before la.
Ccatrole, patleata vltk alcokollc
cirrhoala.
tllC; CIBIBOSISi OBIIBt BlOOt;
KBItSM; IBST Tlialllt: SOBSBBT;
CIICIOH) BaOBISIOB; COPPBB; IBaCB
HiiEiTS; oBoos; amis; urn;
DISBaSBS
a) Caaalatlta excretloa 0.75-3.15 he
after 16. « aeq IT at «tart of 1.12
al/alB iBfaaloB of 2.5f IgSOt
heptakylrate. loBpregaaat «caaa with
l«loayoaaa
b| 1-kr to 5-hr aeaa cvaalatlTe
«iccetloaa after 2*.6 a*g IT and 82. »
••q IB. Bclaaptic aoaea.
art us: iiansioai CBBeBaici:
CORPtBtTITB (TllOtTIOISt BBtSOBBRBIT
BETBODS
Bean valuta all greapa daring »
eiperlaeatal perlota of « 4«ja eack.
Sobjecta received 919.78
(I13.98-«24.93| eg Bg/day vltk basal
diet or iiltk baaal diet plas 1«.2
g/day aappleaeat cellnloae,
kealcellaloaa or pact la. Seall
ckangea In aeraa ccataat or urinary
deration dae to extra fiber,
algnlflcaat change • In fecal alaaral
leaa.
faaltky adolaaceat boya
BZTM.9; TBJCt BtlBBITS; BIIBULS;
COPPEBi ZIIC; BialBSIQH; BtOCD SEHOH;
OIIIB; FBCBS; IDOLZSCBRS; FIBBES;
CCBPtltTIIE BTILOtTIOIS; IBBtlSU
a) Lou fiber diet tlaa 3S6 a; Bg/day
(or 26 daya
t) Blgh fiber diet pl«a 322 ig Bg/day
(or 26 daya
lean • or - S.B.
Saaplaa collected daring last 7 daya.
lalaace data available.
31-58 yr old MD
BETUSj TlaCE BIBBERS; BIBBULS;
OIIIBi aOOUSi TECIS; CaLCIOB;
BJOIESIOa; I SOU; SILICOI: COBPlBlTITt
ETIIOWIOIS; DIETS: FI8BBS;
BRaBOLISB; BtlTiaiD
BEFBUICE
Daggin. e.e.
tynekaa. B.C.
Dale. I.E.
Bvaaa, B.I.
Tiller. D.J.
197*
salllvaa. J.t.
Jetton, B.B.
Batch. I.E.
1979
Ckaaley. i.e.
1979
Dreva. L.B.
Xlea, C.
Fox, B.B.
1979
Kelaay, J.L.
Bekall. It. a.
Prathar. E.S.
1979
10
u>
vo
-------
Rand«Uc acid (8 CD
Ban»n«ac«tlc acid, alpha-hydrosy- (4 CI)
90-6»-2
CP-B8-O3
II 1SZ.U, IIP 1" C
TISSUE
2613
Or la*
EXPOSURE tons
Inhalation
Inflation
Owaal
ftEalTTXCIL
RETROD
fluoroactry
RIJRBSE
or cisss
8
Mtat
a) «7-7» oq/.l
b) 55-97 ag/«l
e) 0-1* og/«l
d) 2-23 ag/il
HE»I
•I 62.5 09/.1
b) 73.5 ag/il
c) «. 2 » or - 3.3
•«/•!
4| 12.5 » or - 5
ug/il
OEIIBtl IITOIIIITIOI
•) Day 1 of atycan* •zpoaac«v •
•cik*r>
t) Second conMcatl** day at >tyr«n«
•iposar*. « >ock«c<
e) Day 1, » control >ork«r>
4) Day 2, » control «ork«r«
e «ork«ra In polyvaUr plaatlca
fUnt, « aiposad to styr«n«.
BIISORERBIIT BETRODi; ORIIE; C»I»D»;
ICOLTS; OCCOPaTIOIll BlllBOS;
STIBBIES; REIU01I1BS; alB PCLIOTIOB;
BHLTR HIHBDS
BEFEBEICE
chakrabarti. S.It.
1979
-------
B>Bgao«M
709-96-5
IB
Itl 5B.9380, It 12M C, BP 2095 C. It 1 •• Bg «t 1292 C. 10 •• Bg at 1510 C
TISSUE
261*
Blood
2615
Blood
2616
Blood,
ntaa
26 1"»
Blood,
•bole
2618
Rale
1 •
IZPOSOII 100TB
aMZTTIClI.
iBIBOD
us
us
._ . . _
us
n
BOBBEB
or C»SBS
a) 23
b) 12
c| 17
d| 5«
•I 37
n "
41 3*
k) 38
i) 7
j) 9
k) 17
11 7
•) 5
n) 18
o) 9
.
33
11
IIIOE
-.
a) 10.0-23.8 ppb
b) 10.6-29.6 ppb
c) «.2-10. 1 ppb
d) 3.6-11.9 ppb
•) 2.7-1*. 1 ppb
f) 3.6-10.5 ppb
9l 2.7-13.3 ppb
h) a.o-ia. 1 ppb
i) 6.0-10.8 ppb
j) 5.0-10.0 ppb
k) *.«-9.3 ppb
1) 5.5-9.6 ppb
•) 2.6-10.8 ppb
n) 1.3-20. 3 ppb
o) 7.5-15.0 ppb
5-16 09/1!
3-21 B9/al
1.230-8. 23 S ppa
(HBIT
mi
a) 16.9 ppb
b) 20.1 ppb
e) 7.31 ppb
d) 7.2 ppb
•I 7.5 ppb
f) 6.9 ppb
9) 6.S ppb
k) 7.7 ppb
i) 8.1 ppb
j) 8.0 ppb
k> 7.2 ppb
1) 7.2 ppb
•) 7.7 ppb
n) 11. a ppb
o) 12.5 ppb
9 ng/al
11 ng/«l
3.135 pp.
?»GP)
CEIBU1 IBFOBRaTIOE
B«vl««
BITU.SJ COPPBB: noi; UGBBSIOB;
RlBGaEESI; SIIC; ISTllLOPROTIIBS:
BBEOR1TOID altBlITIS; BBTZBI
•1 0-3 yc old hoipitil pktt«it«
fc) *-6 yc old hoiplttl p«ti«nt«
c| l««ld«nt« < 1 ki froi aMltcc, tg*
2-3 rt
d) (••ld«nt« 1-2 k« (coi •••lt9«
2-3 rr
•I I*«ld*nt« >2 ki fro* •••lt*r, «g«
2-3 jr
(| »9« 2-3 ji, blood Pb < 10C ppb
9) ig» 2-3 ji, blood Pb 101-150 ppb
k) 19* 2-3 rt, blood Pb 151-200 ppb
1) lg« 2-3 It, blood Pb 201-250 ppb
]) 19* 2-3 rt, bloed Pb > 250 ppb
k) Ctbl* ftetotr «otk«n, blcod Pb <
200 ppb
1) Cable (actor r «ork«c». blcod Pb >
200 ppb
•) totk««, M«lt«t, blood Pt 101-200
Efb
i) lotkat*. >Mlt«t, blood Pt (01-500
FFt
c) lotUti, mltot. blood Pt 701-800
FF>>
Catck >abj«ctff *9«d 2 BO oc cld«t.
BtTaLS; CiDnaN; CCPPB1: IBOIj LEtO;
BIBGABBSB: IHC; BIOODj BLOOE SBEOH;
SROKIIQi OIlL COBTllCBPTIfBS;
IIDOSTIIBS; SBBKBBSl IDOLIS;
C8ILOBBB; SBI; BBTBBBLHDS
Btaltkr dooot*. a9«d 21-«1 yt
Blood aaapl«< proridcd by OBbatto I
(•9lonal Boapltal, Incona, Italy.
HITILS; laBOIISSZ; COB I LI; CCPPEB;
B10CD; BtOOC SBBOB; ITH.T
B«althy doooil, «g«d 21-53 yc.
Blood B«apl«< ptovidcd by UBtctto I
Kglooil Boapital, incona, Italy.
•ITtLS; RIBGIIESB; COBiLT; CCPPEB;
ElOCD: BLOOD SEIOB; ITtLT
Scalp halt
Ccaoti ftoa 2 Tillages of valka
of T*a«tuala.
9IIB: TEBBtOEUi (lETlLS; TBiCE
IttflEITS; SQDIDB; IIOSIWUB: HtlCOl;
CBIOBIRE; POTISSIOB: SClKDIOE;
TIIHIOB; TiUDtOH; CHBORIOR; GOLD;
RIIOllBSB; IBOB; COBILT; BICKEL;
COPPBB: Zinc; tDSElIC; SBLSII1B;
eiOBIlE; BOBIOIUB; STBOITIVR; SI1TEP;
tlTIIOKT; lOCINt; CISIOH; B1IIOH;
ll«Tfl»inB; CEBIOK; stntBIOK: BBRCOBT
BBFE1BICE
SoraBBOD, J.B.J.
1978
Zialhals, 1.1.
d«l Ca*tllko, t.
R«tb«. I.P.H.
>ibo«o, t.t.E.
1978
Baxiatelll, ft.l.t.
Bocch«ttt, 1.
1975
n«xat*lll, (t.l.l.
Boeckcttl, 1.
1975
P*tkOD8, A.K.
Tclaadla, J.4.
Di*B». I.
1 977
CO
-------
Hanganaaa
7a39-96-5
Itl SI.9JDO, HP 121* C. BP 20«5 C. TP 1 •• Hq at 1292 C, 10 •• Hq It 1510 c
(COITIIOKO)
TISSOE
2619
1*1 C
2620
KidnaT
2621
Line
2622
tlTaC
BIPOSO'IB BOOTH
HU.TTICU
BETHOD
US
ES
.
ts
IOHBBI
or c»s*s
• 1 179
b| 108
e) 102
d| 109
a) 133
bl 71
c) 8»
a) 91
b) 10.7
el 9.17
IIIGE
a) lot gl»an
b) lot gl»an
c) lot 9l?an
4) lot glTan
a) lot glfan
b) lot glfan
c) lot glran
•) lot gl»an
b) lot giran
e) lot gi»an
(IBIT
SE»I 1
1
a) 0.«3 nj/g
bl 0.86 ug/g
c) 0.6* ug/g
4) 1.3« 09/9
Scoacttic aaaoa
a) a. 05 ppa
b) a. 35 pp.
cl 2.86 ppa
a) 9.11 ppa
b) 10.7 ppa
cl 9.17 ppa
nail
iiroRnmoi
a) Hala children
t| Faaala children
c) !«!• adulta
d) raaala adolta
Cocralation batvaao nn add aai.
Iddltloaal data.
Scalp halt. Cancaaians ID IT, agaa <1
to gcaatac than SI ft.
BITU.S; TBlCB ELIDEITS:
IOIOI: CtDBIOB; CHIOBIOH; COIPEIi
IIOI; LEtD; LITRIUfl; HIietllSB;
BIICDII; lIOELi 5IIZIIOH; SUTtll;
Til; TUJDIOB; ZIIC; RIIB; »(B;
ICOLTS; CBILOBEI; SEIi COBPAHTITE
EvatoiTtois: DOST; SOILS; in
POLUTIOI; OBB1I aBBtS; IE! WtK
a) lo canal dLaaaaa
b| tcata canal fallana
c| Chronic canal failnra*
c) diffacant tcoa a) and b), p<0.01
aca dcy «t taala.
lotopalaa at OCL1 Boapltal.
TttCE BLBBERS; BEtlLS; lOTOSSIES;
CltirOIIIl; H1DIETS; IITEB; 5PLEBI;
DISE1SBS; BTPBITEISIOI; SOOIOR;
COT1SSIDB; CilCIOJ; PBOSPBOBOS;
BIOISSIOR; CaDIIOB; ZIK: COiPEI;
HID; IIOI; B1IC1IESE; UOBIIOB;
SItlCOl; TITIIIOB; C081LT; IICKEL;
ICITBPIIIIR: Til; CBMHUOR; STBORIOB;
BIBIOB; LITBIOR; SILVBB; TIIUIOR:
ECIOI
a| lo canal dlaaaaa
b| tcata canal (alIdeas
c| Chconlc canal failacaa
Dcr «t baaia.
lotopalaa at OCL1 Boapltal.
TBICB ELBHEItS; BBttlS; 10TOFSIBS;
CllIFOIlIi; IIDIEIS: tlfEB; JPIMI;
DISBlSBS; RTPEBtBISIOl; SODICH;
COTtSSIOl; CIICIOB; PHOSPBOIOS;
•1GIBSI01; ClDBIOH; II1C; COCPBI;
tlaD; IIOI; 8HOIIESE; UOIIIORt
SItlCOl: TltillOB; COBILT: lICKBt;
BOLIBOBIOB; Til; CB10BIOB; SIBOITIOB;
BIBIOHi 1XTBIOR; SIW8I; fllUXOl;
tCEOI
ratal tiaaua. lav lav
REHIS; TltCB BLEBBIISl
COfPIB; BIIGIIESI: SEIBIIOB;
CBIOBiaB; IEIBOII; fBTOS; BIOOD
HkSBk; BBTTBMCTTU; 1ILK; ITTBB;
OITTBD (IIGDOa; lOMITIOIlt
iinotic TIOID
BErEBEICE
Craason* J.P.
Btnnaca, T.I.
Bqagacnac
Plnkacton, C.
1975
J. t.
Indcapcaalt, S.
alaxandac, G.f.
Gonlck. B.C.
197»
U>
•P-
Ni
Indcapcaalt, s.
llaiandac, G.T.
Gonlck, B.C.
197»
Sha>. J.C.I.
1980
-------
langanaaa
7139-96-5
BB
It! 5«.9380. IP 12M C, BP 2095 C, TP 1 aa 89 at 1292 C, 10 aa Bg at 1510 C
(COITIIOED)
TXSSVB
2623
Laag
262*
Laag
262S
Lang
2626
tang
2627
noda
- —
BIPO301B BOOIB
,
IIILTTICIL
BETBOD
BS
IIS
BS
BS
10BBBI
OF CISSS
30
20
a) 129
b) IS
1*
II MI
lot Aatactabla-15.5 ag/g
Acy at
lot gltan
a) 2.4-9.7 ag/g Acy it
b) lot glTaa
2.H-9.7 ag/g Acy wt
lot glTBB
(HIT
Bill
lot gl*aa
6.9 ag/100 g Acy wt
a) 6.1 ag/g dry «t
b) 7. 1 ag/g Acy vt
5.8 ag/g Acy vt
•.6 ag/100 g Acy wt
PI1B)
GBBIIIt IBFOIBITIOB
Sactloaa of lunga tcoa aabjacta who
kaA baan bltaalaoaa coal alaaca foe
23-50 yc.
BITUS; TIICI BLBBBRS; IL OB II 08:
EiiiDi: BniuioB; Boioi; CBiOBioa:
COPPI1; GBIflinOB; IBOI: 1EIC;
BIGIBSIOB; 8IIGHB3B; IICKEL:
silicon SItTEl; Til; TITIIIOB;
TIIIDIOB; 10 BBS; COIL; OIITBt STITBS;
OOIBTZ] BIIIIILS
iBclaAaa appac aoA lowar lobu, and
lyapk aoAaa of long. lAAltlcnal Aata
BTBllabla.
Sactlona of langa fcoa aablacta wko
kaA baaa bltoalnooa coal alaacs foe
15-50 yc In lalaigh Coaaty. laat
Tlcglnla.
SITUS: TIICI BtB8BwTS; COU;
HBTLtlOBS COBlLTl CBB08IOB; COPPBB ;
IIOI; LIID; BIGIBSIOB; ailGIIESI;
I1CKBL; TITIIIOB; TIIIDIOBl tIK]
IDMSi COBPIIMITB ITI10ITIOI3;
SILICI: QOIITIi ttltl IODBS; IBST
TIIGIIII
a) coal ainaca
b) coatcola
sactloaa of langa (COB dacaand coal
alaaca aaA Don-coal ainara fcoa
lalaigh Coaaty. IT.
BIIUS; TIICI EL BB BITS; COIL; SILICI;
BIBTLLIOB; CBBOBXOB; COPPB8; IBOI;
LIID; BIOIESIOB; BliellBSB; lICKBLl
TITIIIOB; TIBIOIOH; SIK; LOWS;
COHPIIITITB BTILOITXOBS; IBST
TIIGIIII
langa of aaana. Iddltlonal data
aiallabla.
Tlcglala bltaalaoaa coal ainaca.
BITUS: TIICI BLIBIITS: COIl; SILICI;
BiiTttioa: caioBiOB; COPPEI; IBOI;
tllD; IIGaESIOB; BIIGIIBSB; 1ICKBL;
T1TIII04; TIIIOIOB; tIK; tOBGS;
CCBPIIITITE ETItOITIOIS; IIST
1I1QIIII
Pglaonacy hllac lyaph nodaa troa
aabjacta who haA baan bltoalcooa coal
flcglnla.
8ITILS; TBICE ItiaiRS: COIL;
BIITLLIOl; CCBILT; CBIOBIOfl: COPPBB;
IIOI; IBID; BIGIBSIOa; RIIGIIESB;
IICKEL; TITIIIOB: TIIIDIOB; IIIC;
tOBGS; C01PIIITITB ETIIOITIOIS:
SIIICI; gOIBTI: IYBPH IODBS; VBST
flBGIHt
USFIUICB
Crabla, J.T.
laanaa. B.G.
•olowlcs. F.I.
(nott, 8.J.
Bolti. J.I.
Gocakl. C.B.
1967
Kaanan, B.G.
Ccabla. J.T.
saallwooA. I.I.
Caclbacg. J.B.
1971
Swaat, D. T.
Ccoaaa, I.E.
Ccabla, J.T.
Caclbacg, J.I.
Lainaact, B.S.
197»
Caclbacg. J.B.
Ccabla. J.T.
tlatlaca. 1. P.
Bolti. J.L.
Baaac. P.
lolowlcz, F.B.
1971
Kaanan, K.G.
Ccabla. J.T.
SaallwooA. l.«.
Caclbacg, J.B.
1 Q71
1 » ' 1
i
U)
-------
langanese
7*39-96-5
no
ItU S«.9380, HP 12«a C, BP 20"5 C, V? 1 >• Hq at 1242 C. 10 •• Bg at 1510 C
(COITIIUED)
TISSUE
2628
Silk
2629
Bilk
2610
Hall
2631
SplMn
2632
Orlne
EtPOSim BOOTR
mlLTTIClt
BETIOD
US
n
BS
11
IOBB5R
or cisc
a) 28
bl 39
c) 23
4) 13
•) 26
f) 30
a) SO
bl SO
0| 3»
4( 23
at -M
b) 31
c) 63
•t 1
bl 1
BUG!
a) Rot given
b) lot 9 IT n
c) lot glv n
4) lot giv n
•1 lot 9!* n
f| lot giv n
a) lot given
b) lot gl»«n
cl lot given
4) lot glf«n
a) lot given
b) lot given
c) lot given
al 0.10-0.6* 09/2* he
b| 0.093-0.61 ag/2« he
nEki
a) 1.91 t or - 0.21
tg/100 ll
b) 2. 38 • oc - 0.33
ng/100 al
c) 2.53 » or - 0.39
og/100 >1
4) 1.75 » at - 0.27
ug/100 ll
•) 1.»1 » oc - 0.51
1} 1.99 • ot - 0.66
an/100 il
__
a) ». 3 og/g 4ry vt
b) S.2 ng/g dry *t
cl 5. 6 ng/g 4ry et
4) 7. o ng/g 4ry >t
al 1.T2 ppa
b) 3.0* ppa
c) 2.06 ppa
al 0.22 «g/2« he
b| 0.38 ng/2* he
CEIIIkl KFOBBITIO
a) 1-3 10 lactation
fa) 9-6 ao lactatioo
c| 7-9 ao lactation
d) 10-12 ao lactation
•) 13-18 ao lactation
(| 19-31 10 lactation
lblt« »oa«n, 19-«2 Ji age, 22
pclalpacae ao4 16 aaltlpacae.
ElOOO SIROB; HtLRi 9ETILS; LICTITIOH;
ana; caicion; BiOiEsioB: BIIOHESE;
IKIl; COPPEI; II 1C
leviev
ItfTEI; DETILS; TSIC8 ELEHEHS:
CCPPEB; HllGlltSE! SELEIIOH;
CBHOBIOS; ICIBOBI; FETOS; BLCOD
PliSBt: ERTTfllOCTTES; BILK; IIVEH:
OIITEO RIIGDOI; IDUITIOIil
ClflCIEICIBS; 1BIIOTIC FLUID
al Fathers
b) nothecs
c| Rale teenagers
4) Feeale tetnageca
lalae* alao given (oc ae41ani an4
geonetclc eeans.
SO Belanealan faalllea, lean age of
tataacs, *6 IT, aothecs, «1 }C. *3
aale ch!14cen, 12-2* jc and 28 Ceule
children. 12-2* jc.
CIICIOR: SODID1; B1GIESIDH; U.OBHOB;
soiFOR; CBIOIIIE: VIHDIOB;
RIIG4IESB; COPPEI; TUCK ELBKITS;
ElOOD PIESSOIB; III QOIIBa: RBTaLS;
UILS
a| lo renal dlaeaae
bl Icata renal (allarea
e) chronic renal fallacea
a) and b) 4iC(erent, K0.01
talaes era 4ry it taele.
utopalee at oct» Roepltal.
TBICE BIBREITS; BBTILS; aOTOPSIES;
ciiiroini: HDiBTS: LITBI; SPLSBI;
DISBkSBS; RTPE1TEISIOI: SODIOR:
•OTaSSIORj CllCIOB; PHOSPHOR OS ;
BIOIBSIOB; CtDBIOH; tTK: COtPBl;
I!»D; IIOI; HalOalESE; UORINR:
SILICOI; TITaftOR; COBU.T; IICKEL;
ECLTBDBIOH; til; CRIORXOR; SHOHTIDB;
BIBIDB; LitRioR; SILTBI; VHIDIOH:
IOIOI
a) Healthy aale, 6 aaaplee over 9 eo
bl Healthy (eaale, 2 aaaplee 10 ao
apart
Iddltional 4ata available.
BITILS: TRICE BLBHIITS; IISEITC;
EIOBIIB: CtLCIOR; CBLOIIRE; COBUT;
CatOHIOR: CISXOR; COPPEI; RBKOITl
ICCIIB: POTtSStDH; RllCalESB; SODIOH;
• OBIDI01; SIICTIDH; XIIC: HI KB;
IllSaiBHBR BET BOOS
BEPE3EHCE
vaaghan, L.t.
•eber, c.w.
Keeberllng. S.B.
1979
Sbav. J.c.L.
1980
Basironi, 11 .
lolctyohann , S.R.
Pierce, J.o.
Schaaacaula, B.C.
1976
Indrapraait, s.
lleiander, o.T.
Gonlck, B.C.
197*
.. _
Cornelia, I.
Speecke, t.
Hoate, J.
1975
(•BIT PIGS)
U>
-------
7*39-96-5
Itl S*.93BO, HP 12" C. BP 2095 C. TP 1 •• Bg «t 1292 C. 10 » Bg «t 1510 C
(COITIIVIDI
TZSSOB
2633
BIPOSOtB IOOTB
Ingiiation
aitLTTICIL
BBTBOD
US
•ORBBB
OP CISBS
9
1IIGE
t) lot gl»«n
b) lot gl»«n
c) lot gl»«n
BB1I
•t 15 » or - 1.9
b) 13 » or - 0.5
ng^Af
e) 9 » ot - 1.0
ag/Aftf
.
OBIIB1L IIPOIBITXOI
•I 8 itiAlM, 21 4«y« «*ch - 2133 ag
Bo plM 200 *g C»/d«y
t) * •t«di««. 2* 4«T» Mch - 2229 «g
in pli> 600 ig C«/a«f
c) 1 otaATt IB d«y« - 2133 ag Hn plu
1SOO ig C>/AiT
I«n » or - S.I.
1 »ta4y «gqi»l«nt of 1 c«««
B*lMC« >n4 other Att* •T«ll«bl«.
•> patlmt* with piychoiliaroail. 1
• ith hTpircaldar*!, uA 1 ulth
I*g«t>« Al>«ua. >1-63 TE olA. til
IB gooA phrilcal condition.
BRILS; TMCB BtBIBBTS: BZIBU1S;
CICBIOB; COFCBI; BkBGtlBSI: HIC;
CCBMIITIfl mUUkTIOIS; F8CIS;
OBIIBl 1DOITSI DIETS: BBTtBOIISB;
IlLIIOIS
18FRUICE
»»u«n, C.I.
Boltuan, I.B.
Kcaivr* L.
1919
-------
ItalaiU*. p»tai«thTl- <8 CI|
1.3.5-TcUciM-2.«.6-tclaiin«. 1.1. 11, •• ..... p«ntu«thyl- (9 CI)
ce-BK-16
nil 196.30
TISS08
2631
Blood.
placaa
BtPOSORE BODTE
Injection
UM.TTICM.
BETROD
CC
•UBBSS
or cisis
5
ItlGE
a) lot glT«n
b) lot given
c) lot given
d) lot given
«»i
a) 3.00 ug/al
b) 0.33 ag/al
c) 0.71 ig/el
d) O.OR ag/al
GEIIML IIPOBBITTOI
a) Peak, iaaadlatelr attec 2 he IT,
26! ag/«q a
fc| » he aftac IT, 26S ao/aq i
c| Peak, laiadlately attec 2 he IT
InCulon at 80 eg/tq a
d) 2.5 he after IT, BO mg/fq m
phaeaacokloatlc data available
Ittabolltes isolated.
tatleats vith anceaectable cancee.
DI06S; OIOG TBEItPTj CREBOTRntPT;
HOOD PLlSRIi BETIBOII3B;
BETIBOIITES; COBPIIlTITE ETtlOMIOIS;
IIIIESOT4
IEFEIEICE
taea, B.H.
Po«l«, G.
KoTach, J.S.
Eaaaa, B.T.
1979
CO
-------
•CT
1*39-97-6
ig
Itl 200.59. BF -38.87 C. BF 356.72 C. TP 2110(E-3) aa Ig at 25 C. 100 » Rg at 260 C
TISSOB
2635
IdlpOM
2636
Blood
2637
Blood
2634
Blood
inoson IOOTB
alUTTXCIL
•moo
IIS
US
fOBBEI
OF CIS IS
1
1*
•1 929
b) 872
B1MB
lot gl»«
•) 1000-3900 ig/»l
b) 100-800 ng/al
a) lot gl»«n
b) lot glvam
(I BIT
mn
2*0 «g/g
a) lot gi»B
b) lot glraa
•1 0.0*8 » or - O.OM
«9/g
b) 0.05* » or - 0.0«1
«g/g
PtGB)
eiBEBll IIF01BITI01
latopay
3-ao-old Bltk coagaaital h«art
dlwaa* adalttad IB ac*t« c«nal
fallan folloaiag latoilcaticn *la foe coBtcola not gl*«B.
Fatl*ntB polaoaad altk aatbylBBtcary.
tarpon of BBDBE «aa to acaaar*
conduction *alocltl*a.
Clinical •loctcophjalological tavtlag
doaa not aapcoct c«nablanc« of
aathylaaccacf poiaoalag to parlpkaral
BOlTBaacopatkr. Poawibl* IOMC brain
at*a daaag*.
BCTUSj 8BBCOBT; BLOOD | BETH
F01SOBIIG; IB1Q
B«T!««. la[kaal« OB dlagaoatic aljna
and ayaptoaa nblch tucBLab oarlr
•acnlag of toxtclty.
IETIEI; BEICOBT: BRtLS; BET it
tOISOIIIIO; BITIBOIXSB; BElttt
BII1BDS; BBBCOBT IIOSQaBIC CCIPOOIDS;
BtlCOBT OIQIBXC COBFOOIDS; PCPOUTIOI
EIPOSOBBi FOOD COHlBIBaTIOB ;
CCCOPlTXOIaL BitllDS; BLOOD; OBXBB;
BIIB
a) Batarnal
t) Fatal
Dry «t baala
saaplaa fcoa a hoapltals la
laibTlll*, tl.
PLICBBTa; BBtHS; TlaCB BLEBF.BTS;
TIIIESSEB; BLOOD; Bill I COBPlSaTITB
BULOaTXOBS; BEBCTBT: tBID: CaDBTOB;
SILEBXOB; IOBXDIOI; IBOI; SIBC;
COBUT
IEFE1EBCE
Boblllard. J.B.
laaaa. I.I.
JOBacBf K.li.
BOlMEta, I.J.
1976
Ton 8 Big, |.
laataa. B.
197*
OacBtn*r, B.B.
Boff, J.I.
1977
Baglas. B.J.
Bcal. a.B.
SchaUct, t.
IllBOB. D.
Lacaaa, K.
DI«C, B.
BanioBC, B.
schaffn«c. I.
BoCfaan. i.
Da>l», J.
197*
U)
-------
aercurr
1»39-97-6
Bq
It! 200.59. IP -38.87 C, BP 356.72 C, TP 2110(8-3) » Bg at 25 C, 100 II Hg at 260 C
(COITIIDE1)
TISSUE
2634
Blood.
cella
26*0
Blood,
calla
26»1
Blood,
plana
26»2
Blood,
MCOB
EXPOSURE BOOT; i
i
Ingaation
Ing* at ion
Ing* at ion
IIILTTICll
BET/HOD
M
US
It
OP
«i ;
bl
6
6
1
23
a) 12.8-1100 ng/g
b| 3-15 ng/g
a) 0.2-2 ng/«l
b) 0.8-1.5 ng/il
•) 0.2-0.5 ng/al
b) 0.3-0.5 ng/el
•56-15 ag/41
a) lot gir*n
bl lot giten
a) i.OS ng/al
b) 1.25 ng/al
0.38 ng/il
0.*3 ng/«l
lot applicable
(IBZT PaGI)
GEIIBkl IIPOBHtTIO*
a) At* food containing. Bcthy ]«0ccary
b) controls
Total Bg iia«uc«d aa Index at
• ipoaan to and »t«ntlon of H«Rg.
Idalt CMldints of Sv«d«n «Lth no
knovn occupational vxpoaar*.
Coccvlatlon t«t«««n blood Hg l«rels
and fr«gl«ncr of c«ll« vlth
cacoaatid-tfp« ab«ccatlon>«
•on«t«bl«" cbconoscM-tTp*
abccrationi, and anaaploidy.
BITaLSi BEICORT; 1UD; SIIDEI; BLOOD;
POCD COITMIIiTIOl
a) B«for« fish ••«!
b) Iftac ual
Paak» in «.1-1« he. Do««
• [pcoziaatalj 20 09/119.
E«altbr adaltB. 19-«« re old,
••ighlog 68-92 kg.
BtOOO; BLOOD PUSH; BITTRIOCCTIS:
BZICD1T; BITILS; BEIIfTL UICDIT
COBPOOIDS; USHES; CMaDa; DIETS
a) B«foc« (lib aaal
b) Iftar a«al
E«ak» in a.T-1« be. Doaa
appcoxliatclf 20 ag/kg.
(aaltbr adolt«, 19-«« jc old.
••Ighlng 68-92 kg.
BIOOD; BLCOD PLISBI; BITTBIOCTTESi
aiacnti; BEUIS; BETHTL BEICDSI
COBPOOIDSJ PISBBS; CllaOl; DIETS
Chang* in l«t«l> daring continuous
p«citan«al lang*, day* 1-T (fcoi
adalaaion) «ita 12 19 diuccaprol IB
• T«ry 6 kc.
3-ao-old ulth congenital kaart
diMa» adalttvd in ac«t» canal
falluc* follcving intoilcatlcn trlth
aarcaptoMcia. Di«d on day It.
CaaM of daatb uacartain.
Kccaclal narhrotoxicltr
BIBCDII; iota: BETH POISOIIK;
BEUT; LOieS; LITEIJ IIDIEISl BIUI;
BOSCLES; IDIPOSE TISSOIl DISUSB5;
IIPllTS: L1V16E
Sk«ct»lnq, S.
Banason, K.
Banga. C.
Lindatan, J.
Pyaan, I.
197a
Karah««, •!.-,.
Dkablr, P.B.
Clackion, T.».
1980
Xcrahav, 1.1.
Dbakir, P.B.
Clackaon, T.I.
1980
00
Boblllard, j.E.
Baa**. L.K.
Janaan, B. L.
Robert*. B.J.
1976
-------
Incur
7*39-97-6
19
It* 200.59. D -38.87 C, BP 354.72 C, TF 2110(1-3) SB 19 it 25 C, 100 •• 19 at 260 C
(COnilOSD)
TXS30I
26*3
Blood,
Setae
26»*
Blood,
•hole
26*5
Brain
26»«
Be* IB
BIFOSOBB IOOII
iBjeCtlOB
IngeStlOn
..
iBitrticiL
NTBOD
US
us
B08BEB
or CISB
i
6
•1 28
b) 1*
c) «2
d) 3
•I *
n 7
91 2
1
_
BIBQB
B) lot applicable
b| lot applicable
c) 9.0-12.5 89/41
a) 0.3-0.9 ng/el
b) 0.6-0.9 ng/al
B) 0-0.25 ppa
b) 0-0.9* ppa
c) 0-0.9* ppa
4) 0-0.08 ppa
•) 0.06-0.16 ppa
f) 0-0.16 ppa
9) 0-0.1* ppa
_
lot given
(•BIT
Hill
at 19 Bg/Sl
b> 39 aa/41
C) lot glfBB
. .. ._
a) 0.53 ng/el
b) 0. 8 B9/B1
a) 0.06 ppa
b) 0.10 ppa
c) 0.08 ppa
4) 0.05 ppa
•) 0.05 ppa
n 0.02 ppa
g) 0.08 ppa
29 B9/100 9
PIGB)
GBIIIIL XBFOBBaTXOB
a) 2 days Biter Injections:
b| 9 days aftor injections
c) after «ici«lon of abscesses
0.1 el. aabcitaaeonaly at each of 6
differeat altos.
13 jc old
tain OB fall Clexlaa and •ztanaloa of
land.
loaClactaant tondor aaa»a OB araa,
BtdoaoB and 109 vita Botallle
d«nalti«B in th« acoa of tao BBB»«S
aad IB the colon.
BItatS; BBBCDBTi BIOOD PLISBI; 01XIB;
CISB BISTOBXBSl FBBBSYLVtBXl; HBT1L
FOISOIIIG; IMIBSCBBTS
a) Before fiah seal
b) ifter aaal
Feaka IB B.7-1* hr. Doae
approxlBBteli 20 ag/al.
Eaalthy adolta, 19-1* jc old.
«el9hlB9 68-92 kg.
BIOOD) BLOOD CLtSBI; BBTTRBOCT1BS;
BBBCOBf) B BtllS I BBTBTL BBBCDBI
COBFOOBOSl riSHBS: CtBtDl; OIKIS
-
a| ill aalea
t| 111 feaalas
e) Total Bale* and feaales
d) Bale*. 20-*S yr
*) Feaaloa, ]0-«S yr
t| Bales. 56-65 yr
91 Foaalos 56-65 yr
Iddltlonal data afillabl*.
Intopay aaaplu froa Idaho. Deaths
unrelated to Bg poiaoning.
BtlCOBt: BBTItS; BBIIBi LXTBIi
IIBIEIS; BXOICCOBOllTIOBi lOWFSIBS;
IC1BO
latopsy
3-ao-old alth congenital heart
disease adaittod in acute renal
(allare Colloilng Intoxlcatlcn «lth
Bercaptoserln. Died on day 1*.
Caase of death uncertain.
Mercurial nefhrotoilcity
BtBCOBTl TOBIJ HBTIL POISORIM;
Btlltl tOIGS: LITBB; CIDBETSi BBall;
BOSCLBS; IDIFOSE TISSOB; DISUSES;
IIMITS; IIT10B
BsmBHCB
ICrohB, I.T.
Solof. k.
Bobiae. J.
lagner, O.K.
1980
Kershai, T.6.
Dhahlr. P.B.
Clarkson, T.B.
1980
Sabica. J.
Benson, >.
Loosls. 8.
1975
Bobillard, J.f.
Baaes, L.K.
Jensea, B.L.
Boberts, B.J.
1976
I
i
VO
-------
Barearr
7*39-97-6
•4
Itt 200.59. HP -38.87 C, BP 356.72 C, TP 2I10(E-3) » 89 at 25 C. 100 II 89 «t 2CO C
(com ID ED)
TISSUE
2M7
lair
2««a
Bale
26*9
Balr
2650
Bale
BIPOSOI
-------
vEy
7«3*-9T-6
•9
It! 200.59, IP -38.87 C. IP 356.72 C. n 2I10(B-3) aa Rg at 25 C, 100 aa Rg at 260 C
(COBTXNBD)
fXSSOR
2651
2652
Baart
2653
'
265*
Cldaay
BXPOSDIB BOOTS
tULTTXCIL
IBTBOD
US
us
tts
IORHBI
or ctsRs
a) 230
b) 9«
1
a) 58
b) 36
c| 9«
d) 8
e» »
fl 12
9) 1
1
URGE
a) lot glrea
b) Rot giTen
lot gtten
a) 0-15.70 ppa
b) 0-12.50 ppa
c) 0-15.70 ppa
dl 0-3.0* ppa
a) 0.05-0.85 ppa
f) 0-7.56 ppa
9) 0-0.91 ppa
lot gives
(IEIT
RBtl
a) 1.35 ag/g
b) 2.73 ag/g
95 ag/g
a) 1.06 ppa
b) 1.03 ppa
c) 1.0* ppa
d) 0.77 ppa
a) 0.33 ppa
() 0.58 ppa
gl 0.50 ppa
2.32« ag/g
P»3E)
OBIIItl IIFOBRttXOI
a) Bat area 1
b) ratal
Radians. OB dry nt basla.
saaples fcoB * hoapltala In
laahTllle. tl.
PUCBRtt HRTalSi IltCI BIBHIITS;
IIIIBSSIBl BIOOD; BtlEt CORItlttXTB
BUlOtTIOBSl REIdlTl LEtO! CtDRIOR;
SIIBRXOR; BOBIDIOHj IROR) SIRC;
COBUT
latopsy
3-ao-old ultk coagaaltal haatt
disease adeltted la aeata renal
(allure follonlag Intoxication with
aaccaptoaacln. Dl«d OB day 1*.
Cause of death uncertain.
Bareoclal aephcotoilctty
BItCDBt; 1011; BETH POXSOIXIB;
BUST; LOB8S; LITER; RIDRBTS; BBtll;
BOSCLES; tDXeOSE TISSUE; DISUSES;
XirtRTS) ItVtQB
i) til aales
t) til feaalea
c) Total sales aad feaales
d| Rales. 20-45 yr
a) resales. 20— *5 yc
f| Rales. 56-65 yc
91 reaales 56-65 yr
tddltlonal data available.
tatopsy sasfles troa Idaho. Deaths
ancalated to Rg poisoning.
BIRCUIT; HITtlS; Bltll: LITBIS
(IDIETS; BIOtCCOROItTIOl: IOTOPSIBS;
ICtIO
tatopsy
3-ao-old »lth coigeaital heart
disease adaitted In acate canal
(iliac* folloning iatoiicaticn ulth
aaccaptoBecin. Died on day la.
Caase of death ascertain.
Bercaclal nephrotoiicity
HIRCaiT; lORt: RRtL POISOIIIG;
BltRT; LORQSS LlfRR; KIDISIS; Eltll;
RUSCLBS; IDIPOSB TISSUE; DISUSES;
IirtlTS; ItftOB
IBFBRBBCB
Baglai. I.J.
Bral, t.B.
Sckalert. t.
fllma, D.
Lacsan, K.
Dyer, 1.
Baneoac, B.
Schaffner, I.
Boteaan, L.
Davlea. J.
197*
Bob! Hard, J.E.
Rases, I.E.
Jensen. B.I.
Roberts, R.J.
1976
Oabica, J.
Benson, I.
tooais, B.
1975
loblllard. J.E.
Bans, L.K.
Jeasen. R.L.
Roberts. R.J.
1976
10
-------
nercury
7»39-97-«
Bg
Its 200.59, IIP -3D.Hi C, BP 356.72 C, fP 2I10<»-3) >• Bg At 25 C, 100 •• Hg tt 260 c
(COIHIDEO)
TISSUE
2615
Llrer
2656
liter
•
2657
tang
2658
tang
EIPOSORB IOOTE
i
• MLTTICll
BETBOD
Dithlxone
t»S
US
ROBBBE
OF CISC
a) 61
b) «5
c| 106
4) 1
•1 5
(I 12
g> 6
1
1
1
B»ISB
a) 0-2. 1 1 ppi
b) 0-5.80 ppi
c) 0-5. 80 ppi
d) 0-0. 37 ppi
e) 0-0.01 ppi
f) 0-0.31 ppi
9) 0-2.26 ppi
lot given
lot applicable
lot given
HEM
a) 0.15 ppi
bl 0.53 ppi
c) 0.3* ppi
4) 0.19 ppi
•) 0.1* ppi
C) 0.06 ppi
gl 0.63 ppi
1.201 ng/g
720 19
«8« og/g
CEIEM1 IIFOSntTIOK
•1 111 ««!•»
t) 111 tellies
c) Total sales and teiales
4) flilvi, 20-*S jc
«) F*ial». 20-«5 fc
(I nalai. 56-65 yr
g) r«ial«i 56-65 yc
•4ditloaal data avillabl*.
Igtopi; •»;!•• froi Idaho. Deaths
vncvlated to Bg poisoning.
BIlCOITi BBTJLS; BMII; IITEB;
IIDIETS; BZOaCCOIOlinOI: 10T07SIES;
ICIHO
__
totopir
3-io-old ilth conginital heart
diuas* adlltted In ac«t« renal
tallan tollo«ing intoslcatlen eith
•cicaptOMEin. Died on day 11.
Cause of death uncertain.
lercurlal nephroto«lcity
BIBOJII; toil; !IETaL POISOIHG;
BtiITi LOIGSi tlfSi; KIDIETS; BBall;
BOSCIBS; tDIPOSE TISSOIj DISUSES;
imiTS; LtflGE
litopsy. Beccacjr-Cllled bag of
Intestinal tube ruptured In
ocopharyni 22 yr earlier.
Idilnlitcatloo Hospital, lest
loibury, Ba, who died of pnetmonla.
ckronic long disease, chronic pleacal
etfoslons, palioiary gtanaloias,
bionchlectails, thoaoht da* to slo>
progressive Clbrosls ceased ty Bg.
89 glabales la sany foci In loner
lobes sarroanded by dense tltcoss
tissue. Espty spaces left by 89
igccoinded by saltiaocleatcd giant
cells, epltbelold alls, Clbioblasts
in the peciphery. Bronchial eacosa
shooed hypcrplsstic changes ilth
local ossification. Bedlastlnaa
tilled »lth flbroM adhesioni.
BHCOIT; RETllS; LOMS;
BISStCBOSETISi 10TOKIBS; CkSB
BISTOIIES; DISB1SBS
_ .
lltopsy
3-io-old »lth congenital heart
disease adiltted in acate renal
(ailare Collailag intoxication rtth
larcaptoaerln. Died on day 1*.
Cause of death uncertain.
Btrcarlal nephrotoxiclty.
BtlCOIT) 1011; 8ETI1 VOISOIIBO;
BEUt; LOIOS; lITEit KIDIETS; BSall;
BOSCLESl aDIFOSE TXSSOS; DISUSES;
XIMITS: tlTIOB
StTtKKt
Gabica, J.
Benson, w.
locals. 1.
1975
Boblllard, J.E.
Eases, L.K.
Jensen, B.L.
Poberts, B.J.
1976
Dxaa, T.J.
Sxabo, s.
Chang, T.c.
1977
Bobillard, J.E.
lues, t.K.
Jensen, B.L.
Eobects, S.J.
1976
u>
w
ro
(IEIT P»GB)
-------
7«9-97-6
Bg
It! 200.59. If -38.87 C, BP 356.72 C. TP 2X10(E-3) u If at 25 C, 100 •• 89 at 260 C
(COITXIOBD)
TISSOB
2659
Basel*
2660
Placeata
2661
Orln*
2662
Orln*
EXPOS01B BODTB
Ingeatlon
Deraal
"""
aiainicu.
BBT800
US
us
Dlthlsone
IDBBEB
OF CBSBS
1
1061
39
1
UIOB
lot gl»*n
lot gi»*n
20-930 09/1
a) lot applicabl*
b) lot applicable
(•EXT
BBIB
227 09/9
0. 129 » or - 0.161
lot glr*n
al 1.6 B9/1
b| 2. B ng/1
PtlB)
GEItBlL IIPOIIMXOI
mtopay
3-ao-old «itk eong*nltBl haart
diaeaae adalttad in acat* nnal
tailor* follonlng intoilcaticn with
aercaptoaaclo. Died on day IB.
Caaa*) of d*ath uncertain.
BBrcorlal niphrotoilclty
BIBCOBT! 1011; HBT1L POISOIIH;
BUBT: LOIGS! LITBI; KXDHIS! BI1II;
IOSCLIS; IDIPOSE TISSOB; DISUSES;
IIFIITS; LBT1GE
Or} *t baaia
Saaplea froB a hoapltala In
laahvlll*. 11.
PlaCEITa; RBTlLSi TlaCB BLBBIITS:
ItllBSSBB; BLOOD; BUB; COBPISaTITE
CULOUXOIS; BIBCOBT; LBaO; CtDIXOB:
SBLBIXOR; IDBXDXOH; IBOI; IX 1C;
COBILT
Pongicld* a*thoi;*thrl mrcnclc
ace tat* (21 *tBTln*rc«ric chlorld*
and 12% gaaaa BBC) *U*d at a ratio
of 1.8 g/kg corn.
BaabtcB of th* Tiling* of XBlo«l In
aoathern Ghana.
Ibdonlnal colic, diarrhea, nausea,
Toaltlng, anonila, fatlgn*. asmcalar
(Bin and/or central n*r>oo« jyatea
lapairncntB.
C*ath da* to dehydration, ahcck and
cenal tailor*.
aims: IEBCDBI; FOIGXCXDBS; ORIIB;
FOCD COIT.BIIITIOI
a) tt adnlsalon
c) It th* tlB* of probenecid therapy
(1.9 ag lg/2« hr)
27-yr-old aal* occapationall) *xpo**d
to Rg.
8*rcury *nc*phnlopnthy
Eltcapryaaldal aotor diaocd*r>
Incladlng (alklng ataila,
Bdladochokln*sla. lo pyraaid track
signal, palleatheali, >*nalti>lty to
pcstnr*.
FISROTR; HBICOBT; BETH. 3; HEIal
(QISOIIIG; DIXIE; BLOOD; SPItlL
FtOIO; GEIRtIT; IBDBOLOGIC
BIIIFESTtTIOIS
IEFBIBICB
loblllacd. J.B.
Baau, L.I.
J*n»*n. I.L.
Bob*rt*, B.J.
1976
Baglnn. H.J.
Brol, a.B.
Scholert, i.
lllaon, D.
Lacan, It.
Dyer, I.
Rnnaonr, B.
SchaCfnar, I.
Boffnan, L.
Da»l*», J.
197»
Darban, L.K.a.
197»
Cranar, R.
Banaod, B.
Billiard, R.
Roorat, J.
Raaaars, B.
1978
-------
integer
7*39-97-6
•9
It! 200.S«. HP -38.SI C. BP 356.12 C, It 2X10(E-3) u Rg at 25 C. 100 II D9 at 260 C
(CORTIIOED)
TISSUE
2«63
Orlna
266*
Orloa
2665
Orlnaj
26C«
Orina
tlMSDIE BOOTS
Ingaatlon
Injection
IIILITICU
RETROD
-
It
us
IOHBSB
OP CASES
-r
al 1
b) 1
1
1
IllGB
a) 2.3-11.» Bg/2» he
b) 2.S-6 ag/21 hr
lot giran
a) lot applicable
b) lot appllcabla
c) 500-600 05/4 ay
flE»ll
al 7. ] «g/2i hi
b) «. 2 ag/2» he
<1S ng/2« he
a) 282 ag/lay
b) 900 ag/day
c) lot gl»an
GE*CUL iiroBBiTioi
Batian. tiphasi* oa diagnostic signs
and syiptois ihich facnlsh ««rlf
•icalag o( toricltj.
>I«IEI; HEBCOBT; HETaLS; BETIL
(OISOIIWG; aiTtBOLISB: 8B1LTB
HltlBDS; REBCOBT IMtGllXC CCRPOOIDS;
HIICOII OBGtllC COBPOOXDS; PCPDUTIOI
EIPOSOBB; FOOD COIT1HIUTIOI;
OCCOPITIOIlL HaXaBDS; BtOOD; OBIIE;
BUR
a) Bail thy «al«. 1 aaaplaa OMt 3 ao
b) Raaltay faial*. 2 aaaplaa 10 ao
apart
Iddltlonal data aTallabla.
BITtLS; TBkCB ELE1ZITS; »IS!HC;
BIOBIIE; CI1CIOB; CBLOUIB; CO BUT;
CBIOBIHK; CESIOB; COPPBB: 8IBCORT;
ICEINE; POTISSIOB; RIIStlESB; SOOIOB;
BOBIDIOB; SIUIIOB; ZIIC: DIIIB;
BtMOBEBEIT 8BTRODS
ticc«tlon/2« hr. lhl« laTal
conaldacad nonal. By 3 nk all Rg,
tlalbla by I-ray In GI tract, had
ptsiad Into th« facva.
11-yr-old itla lng«at«d 20« 9 (15 al)
of Bg fro* clock pandalaa.
Traatad lith 111! apaclanta.
davalopad no ayaptoaa.
BIBCOBI; RttlL POISOIIIOs
OlSnOIITESTIMl STSTBBi FECIS;
OBIIB; OIITSD IIIODOB; LITtGIj C1SB
BISTOBIES
a) 2 daya attar injactiona
b) 16 daya attar Injactlona
c) »ftar atclaloD of abacacaaa
0.1 al, aabcatanaoaaly at aach of 6
dlCfaraat altaa.
13 yr old
BttHS; BB1COBT; BLOOD PUSHI; OIIIE;
MSB BISTOIIIS; PBBBSnnilat
(OOLBSCBITS; nrriL POISOIIIG
REFEHEIICE
Garatnar, B.B.
Raff, J.E.
1»7T
cornalla, B.
Spaaeka, I.
Roata, J.
1975
•right, 1.
Taoaan, 1.8.
Cactac, G.r.
1980
Krohn. I.T.
solof. 1.
Boblna, J.
lagnar, O.K.
1980
-------
Baccary(1»). aatkyl-. 1m (8 CI)
••ccu7(1»|. aetkyl- (9 CI)
22967-92-6
C-13-Bg
N 211.63
TI330B
2667
Blood,
calla
2668
Blood.
plaaaa
2669
Blood.
«kola
BXIOSUII toon
X*g««tloa
Iigaatlon
logaatlon
IULYTIC1L
BRBOD
IDBBBI
or cists
6
6
6
I1MI
•I 1.S-ia.8 ag/kl
b) 78.7-123.8 ag/»l
•1 0-0.5 ng/al
b) 2.9-6.7 ng/al
•) 0.9-7.2 ag/il
b) 39.1-59.2 ig/il
nil
a) 7.7 n4/al
b) 102.8 ag/al
at 0.2 ng/al
b) «. 6 a«/al
al 3.6 ng/al
b) «8.9 ag/il
GIintL XINI11TXOI
a) Mtoc* flak a«al
b| tttac aaal
t«aka la *.7-ia he. Ooaa
•ppcoilaatalT 20 ag/kg.
laaltkr adalta, 19-a« yr old.
Mlgklag 66-92 kg.
BIOOO; BLOOD niSlll I1TTB1OCTTBS:
BIBCOIT; BBTalS: BBTBTl BIlCDBt
COBPOOID3; HS8BS: C1IIDI; DUtS
a| Baton flak a«al
b) iftar aaal
laaka la 4.7-1* kr. Doaa
aepcoilaatalf 20 ag/kg.
Eaaltkf adalta. 19-«« yc old.
aalgklag 68-92 kg.
BIOOD; BLOOD FllSKi; BBTTI10CTTC5;
B11C01I; BITllS: RRBTl BBBCDlt
COBPOOIDSi FISBBSi CIIID1; DIBtS
i) Batoca flah aaal
b| aftac aaal
raaka la «.7-ia kc. Doaa
appcoilaatvlT 20 ag/kg.
Baaltay adalta, 19-«a yc old.
aalghlag 68-92 kg.
BIOOD; BLOOD PL1SII; BITTBIOCTTBS;
BIBCVBT; BBTalSt BETRTL RBBCtBT
ccaroaiDs; HSHBS; CIHDI; DIETS
umnci
Kacaktv, T.S.
Daaalr. r.B.
Clatkaoa, T.I.
1980
(anaaa. T.O.
DkablE. P.B.
Clackaoa, T.I.
1980
Karaban, T.6.
Dbaklc, P.R.
Clackaon. T.I.
1980
u>
Ul
Ul
-------
Bethanesalfonanlllde, a>-(i-hydroxy-2-(lsopropylaslno)ethyl|- (8 CI)
Bethanesnlfoaaalde, 1- (»- (1-hydroiy-2-<(1-n*thylethyl| aeino)ethyl) phenyl) - (1 CI)
3930-20-9
C12-B20-I2-03-S
HI 272.36
TTSSOB
2670
Blood.
plessa
2671
Blood.
plasna
2C72
Orlne
EXPOSURE ROOTS
TngCtStlon
Ingest ion
1 119* it Ion
UlLTTICU
BETBOD
PlttOrOBetr y
Fluoroeetry
•*•
riaorosetry
BORBZB
or CUES
32
•I 7
bt 6
c) 6
21
Bales
al 1.375-0 .(5 uo/il
b) 0.72-1.90 ag/el
a) 1420-180 ng/sl
b) 120- 890 ng/sl
c) «20-SO ng/sl
a) Bot given
b) Bot given
flEftl
_
a) lot eDDlicable
bl lot applicable
a) lot applicable
b) lot applicable
cl lot applicable
a) 87.6 • or - 5.8«
of dose
b) 78.5 » oc - 6.7t
ot dose
GEIIBIL HfORHlTIOll
attec 160 19. initial value, 0.95
oq/el at 1 at
t) Bange of iadivldaal Tales at * he
after 160 »g
Kinetic parameters not correlated
•1th those of antlprrlne or liver
?-*50 activity.
2! patients ulth hypertension. 8 tilth
angina pectoris, vith norsal kidney
and renal function, fasted, iges
11-65 yr.
DB03S; rillllD; BLCOD KaSBa;
IIIIIBIBTTBBIC aGBBTS; BIXTBIS;
BITaBOLISB; BYPEBTEBSIOB; BEUT
CISB1SES: aOOLTS; aiTZPTIETICS
a) Blderly, 2.9 and 2* hr after
160-19 dose. Initial value, aoo
•9/sl at 0.5 hr
b| Toang. healthy, 0.5 and 3 hr after
160-sg dose, final valve. 135 ng/sl
at 2* hr
c| loang, healthy, 3 and 2» hr after
80-ag dose. Initial valae, 65 ng/sl
at 0.5 hr
Bcnoezponentlal decline. Estimated
fros graphs.
Bealthy Mies, 19-35 yr old. sale t
fesale hypertensive patients, 60-7 •
yr old, sose on ditretic*. Tasted
overnight.
ledectloa in nazlsas eiercise heart
rate correlated eith log plane
level, r-0.6*. K0.001. Use
redsctiois in blood pressure.
DB08S; BET1BOLISB: IGE; COBP1B»TITE
BfltOlTIOBS; BIOOD PllSBt; OHBE;
ITPEBTEISIOI; DBOG THEBIPT; IDTJITS;
HOOD BBSSSOIE
a) lonag
b) Elderly
0-18 tr caailative excretion of
ancksnged drag after 80 or 160 eg.
Bealthy sales, 19-35 yr old. sale E
fesale hypertensive patients, ages
60-7a. sose on dieretlcs. Fasted
overnight.
Bedectlon in aaiieoa etercise heart
cate correlated vlth log plana
level. r-0.6», p<0.001. Use
redactions in blood pressure.
DID8S; BETIBOHSB: aQE; COBPIBITIVB
BfllOITIOIS! BLOOD PUSBa; OIIIB;
BTPBBTEBSIOB; DIOO TBElaPIi IDOtlS;
IICOD 9BESSOBB
BErEBEICE
Sotaniesi, E. A.
Inttlla, B.
Pelkonen, 0.
Jarvansivu, P.
Sandgaist, H.
197Q
Ishisaki, T.
Birayasa, R.
Tanara, 1C.
lakaya. H.
Sato, B.
Sato, It.
1980
Ishixakl. T.
Birayasa, B.
Tavara, It.
lakaya, B.
Sato, B.
Sato, It.
1980
CO
-------
Mtkuol
67-S6-1
c-a«-o
II 32.0*. IP -97.8 C. BP 6*.7 C
TISSUE
2673
Hood
BIPOSOH IOOTI
Mraal
IHLTTICII.
BETBOD
Color laatrT
IOHBBB
or C»SBS
1
SHOE
Bat applicable
BBIE
•0 ag/dl
QBBN1L IBFOBNTIOI
Ptta •eeid««t«ll7 >o*k*d «itl
ittUnol. ippllvd to chill' i cteat
12 kr/al9bt (or 2 aight*. L«r«U in
•cla* and p»iton«l field net
qg»tit«t«4.
8 BO old p«ti«nt idiittcd to ko«plt*l
in Bc
-------
BatkiOBUa, I- (6 CI)
l-natkioDlaa (9 ci)
63-«8-3
C5-I11-I-02-S
?• 1(9.21, 1* 280-282 C
TISSUE
267»
Blood,
calls
2675
Blood,
plaaaa
2676
OclM
(IPOSOIE ROOTS
laaastlon
iDOaStlOB
Ingaatlon
»«»LTTIClt
RRHOD
CC
CC
CC
SOBBBS
or cis is
• I 2.3-3.0 MOlM/100 9
b) 2.2-3.0 MOlas/100 9
a) 3.5-1.9 oaola/1
b) 3.5-H.90 oaolas/1
c) 3.*3-«.92 aaolaat/1
a) 0.17a-0.22l aaolaa/ag
b) 0.177-0.201 oaolat/ag
a) 8.2 aaolas/100 g
b) «. 7 «aolaa/100 9
at 2.7« naolas/1
bl 2. »2 aaolas/1
ci lot giT»o
a) lot applicabla
b) lot applicable
GtlEBIL IirOBBlTIOl
a) >(t«r L-a«thlonio». Pack at O.S
he
t) >ft«c l-«c«trl-l-nthioain. P«ak
at «5 aln
0-« kc can9« of •••a« and ivan packs
in icytkrocftM tftac 0.0605
• •ol«*/k9. EstlittM (coi graph.
locaal adult nbjccti, aboat 2* rr
old, ta«t«d baton and after dox.
•IIIO ICIDS; BLOOD PLtSIt;
CITTHIOCTTES; OHIIE; ID01TS; I OH
a) aftac L-iatklonlna. Paak. 9
«nU«/l at 0.5 kr
b) aftac 1-acatTl-t Hatklonin. Paak
7.38 aioUa/1. at «5 ala
c) Iftac i-ao«tyl-t-a»tkioDlo», attar
acflaaa tcaataant. Paak. 6.37
aaola*/! at O.S hr
0-a he canga ot aaana and 0-1 kr aaan
lacraaaatal la»al» coaputad froa
acaa-andac-tba-cacfa data, attar
0.0605 aaol«»Ag.
loraal adalti, aboat 2*.0 re old,
taatad batora and attar dom.
HIIO 1CIOS; BLOOD PitSB»;
IIITBIOCITES; OSIII; aDOITS: IO«»
•I L-aatEionlDa traataant
b) l-acatrl-L-Mtklonlaa
Bafora to * kr attar 0.0605
aaolaiAg.
loraal adalt Mbjacta, aboat 2« ji
old, bafora aad attar doaa.
IBIIO ICIDS) BLOOD PLI381;
IITTnOCTTBSl OIIIB; aOOlTS: XOU
Staalnk, t.D.
rilac, L.J., jr.
vakar, e.L.
1980
Staglak, L. D.
filar, L.J., Jr.
Bakar, G.L.
1980
Ln
CX>
Stagink, L.D.
filar, L.J., Jr.
Bakar. G.L.
1980
-------
lineal Aut (Io partligs In CIBLIIB).
nssai
2677
tug
MKSOIB 100TI
InkmUUw
_
kill RICH
HHOD
I01BII
OF CIStS
•I 13
b) 10
e| 7
I1IGB
» 2.6-33.0 *g/9
b) 0.2-9.3 »9/9
e) 5-35 ig/9
BEtf
.
a) 9.5 19/9
b) 2.1 19/9
c) 19 19/9
6IIII11 IirORItTIOl
•1 PltUbicgk rMld»t<
t| Ck>cl« *-»•
D«*i*. J.I. 0.
Cnll«r. l.J.
197«
VO
-------
Mineral fiber* (to posting* in CBEBLIIE).
TISSOE
2678
ETPOSOBE BOOTE
Inhalation
aBkirricaL
BETBOD
-
1 icr >jco^)
BOIBBB
OP ClSES
30
BUGS
ai 5-170
bl «70-6750
Cl 370-«.eiO
d) 0.5-«8. 8
e| 150-6,600
f) «7-»,650
g) 22,000- 2»,000; ale )
hi 19.300-3*0.000
i) 15,700-1«6,000
1B»B
a) as
b) 1,800
cl 1,200
d» 7
e| 1,300
f) 900
h| 150,000
1) 80.000
crimi IBPOSIIITIO»
a) 13 Plttafcargh resident*.
octlcal-aize fiber*
b) 13 Pittsburgh resident*, IH->lze
fiber*
c) 13 Pittsburgh re*id*nt*, fiber* <5
o long
d) 10 Charleaton ra*ident*,
optical-lire fiber*
*| 10 Charlaatoo r**ldent«, IB-*li*
fiber*
tl 10 Charleaton resident*, (lb*r* , P.
Barley, R.l.
Daila, J.B.S.
Cralley, !.••!•
197a
CO
cy>
o
-------
Bolrbdaaai
7*39-98-7
la
Itl 95.4*. M 2622 C. »t «825 c (appeal) . TV 1 u 19 at 3300 C, 10 » 19 «t 3770 C
TISSUE
2679
Blood,
plan*
26SO
KldMT
2681
ti»ac
2682
Splaaa
EIPOSOBE BOMB
Inhalation
1I1LITICIL
BETBOD
US
es
ES
ES
IOBBBI
OF CIS IS
•I 1*
b) 2*
ItlGE
•) 9-365 ng/ll
b) 0-3* ng/al
a) lot glvan
b) lot gi»«n
c) lot glvan
•I lot gl»«n
b) lot giTan
c) lot glr«n
•1 lot gi»«n
b) lot gl?«n
c| lot given
(HIT
mi
•) 121 B9/al
b| lot given
•1 1.97 pp. (13X|
b) 1.92 ppi (23S)
c) 2.11 pp. (251)
•I 3.«2 ppe (72*1
b) ».99 pp. (861)
c| S. 01 pp. (8*1)
a) 3.»7 pp. (28%)
b) ». 80 pp. (52«)
c) 3.21 pp. (»7«|
PIG I)
6BIIUL IirOIUTIOl
•I loEkaEa IB aolyfcdaaita coating
pl.nt
b| COBtcol«-*tatent« .oil r«>«rcb
p«r«OBB*l
Iboat 1/2 th« >ock«t« had diarEkn.
joint palm, back palm, b«adacb*«.
aid akin oc kale ckangu.
HOOD; COLCHDC; COPPI1; BOLIBOBWO8;
8I1LTB H1IMDS; IIDOSTU1L PUItS;
ami; iBTUS; IHCB BLBBBITS
a) lo raaal dlaaaaa
E) lent* nn.l tallani
cj Chronic Emal f.llaraa
DC} «t basil
Vaccaat of caaplaa ultk datactabl*
!•*•!• la iBdlcatad IB pacvatkaaaa.
intopalaa at OCU Boapltal.
TUCB BLBBBITS; BBTUS; tOTOPSIBS;
CkLIPOIIIli IIDIITS; LITBI: SPLBBI:
DISB1SBS; ITPEBTBISIOI: SODIOB;
(OTISSIOR: CtlCIOB; PHOSPHOBOS;
B1GIESIOB; CIDBIOB; StK; COfPBI;
IMD; IIOI; BklGUBSB; aiaillOB;
siLicoi: ixttiiai; COBUT; IICIBI;
BCIT1DBIOB; til; CBIOBIOB; S1BOITIOH;
EIBIOI; LITHIOB; SItTBI; TtllDIOB;
IOIOI
a) lo Eanal dlaaaaa
E) icata canal fallvcaa
c) CkEoalc canal falltcaa
Dry >t baal*
Paccant of aaaplaa ilth iatactabla
la»ala la Indicated In pacantkaaaa.
intopalaa at OCL* Boapltal.
T«»CB ELEBIITS; BBTtLS; IDTOtSIES;
CILirollII; (IDIBTS; LITEB; SPLEti;
CISEISES; BIPBITBISIOI: SODIOB:
fCTISSIOB; CIICIDB; PBOSPBOIOS;
BIGIBSIOB; CIDBIOB; II 1C; COI9EI;
HID; HOI: StldlllSE; ILOBIIDB;
SHICOI; TITMIOB; COBILT; IICKBL;
BOIIBDEIOB; Til; CBIOHtOB; S1IORIOB;
BtBIOl; IITBIOB: SIITBI: TtllDIOB:
eoioi
a) lo canal dlaaaa*
c) kcata canal fallvcas
c) Ckconlc canal fallacaa
Ccy «t baala
Paccant of aaaplaa vith datactabla
lavala la Indicatad in pacantkaaaa.
Intopalaa at OCL1 Boapital.
TlaCE ElBBBITS; BETllS; tOTOISIES;
CllIFOBHI; KIDIETS; LlfEB; SPLE'K;
CISEtStS; BIPBPTB1SIOH; SODIOX;
tCIlSSIOl; CtlCIOB; PHOSPHOBOS;
BIGIESIORi C1DBIOB; IT 1C; COFPEI:
II>D; IROI; B1IEMESE; tlOBIIOB;
Silicon; TtTIIIOB; COBU.T; HICKBL;
HCLIBOtlOIl; TH; CBBOBIOB: S1BOITIOB;
tllTUB; LITRIOn; SILTE5; TtllDIOB;
CCBOI
IBIBIBICB
(alcaTana. p.k.
Boaca-Bcaao, B.
Soloaona, C.C.
Cbappall. l.B.
Bantlay. G.
1979
Indcapcaait. s.
tlaxandac, s.T.
Qonlck, B.C.
197a
Xndcapcaait, 5.
ilaxandac, G. T.
Gonlck, B.C.
197a
Indcapcasit. S.
tlaiandac, G.T.
Gonick, B.C.
19->»
OJ
-------
BolTbd«n»
7«9-9«-7
BC
It! 9S. «, Bf 2622 C, BF «825 C (approx) , TP 1 » Hg at 3100 C, 10 •• Hg at 3770 C
(COHTIID'D)
TISSOB
2683
DC in*
EIPOSHIE ROOTE
Inhalation
. _. -,
IIILTTICIL
tIETBOD
us
>OBB!«
or cuts
a) 1»
bl 2«
a) 120-11.000 09/1
b) 20-230 U9/1
a) 1790 ng/1
b) Rot 9l**n
OEItlal IIPOIIUTIOI
a) Vockacs io lolftdtnlt* coasting
Flant
t) Contcol>-ita4«nt« and n««arch
Fa»onn«l
lto«t 1/2 tk« vork«H had di«rrb»«,
]cint palna. back pain*, h«a4acbM,
and akin or hale ching««.
ElOOD; COIOBIOO: CCPPSI;
BltlTB BIZtBtS: IICOST1UL P 11 ITS;
OtHE: DETilS; TBiCE ELBBEIT5
BEFEBEDCE
Balca*«n*/ P.».
Boac*-Eca>o( B.
Soloions, c.C.
Chappvll, I.B.
B«ntl*f, 6.
1979
U)
o>
NJ
-------
aorpki»««-3.1»-A101.1T-(CTClob«tTlMthyl)- (9 Ct)
•2«08-82-2
C21-B29-I-02
n 327.51
TISSOI
2(6*
Blood,
8«E»
BIVOS01E MOTE
Injection
Ingiitioo
inirricit
HBTHOD
B»
oc
108 III
OF CISK
a «
bl •
c) •
A) «
BftBGB
•| 0.2»-2.99 »g/»l
b) 1.13-1. »6 nj/«l
c) 0.0-2. 2T ag/il
A) 1.0«-1.69 ag/il
mi
a) 1.12 no/il
b) 1.32 ag/Bl
c) 0.78 agAl
A) 1.«1 ng/Bl
6IIBMI IIFOIUTIOI
•) 16 KJ, onl. HI u«lyg. aril,
A) 2 ig, 18, ac-«an f»gi«togcmpkr
lo ligament AlCfvnne* b«tM*n
••tkoAi.
DIOOS; BLOOD SBB08i niSOlBBRT
IHBOD5; COBPtltTItB BTtLOITIOIS
iBraincs
PlttMB, (.1.
Biyol, B.F.
1980
-------
flotphlnan-3,6«lpli»-dlol, 1, H-d ld«hrdro-«, 5«lph«-*poir-1^-aet hj 1- (9 CI)
Bocphiaan-],6-diol, •>,i-dldehy4ro-»,5-epoiy-17-aethyl- (5alpha,6alpha) - (9
51-21-2
C11-ai<>-«-Q]
Bl 285.1], BP 141 C (setastatle phase), 25« C (decoap)
TISSOE
2«BS
Blood
26B6
Blood
2Sr>
Blood,
plasaa
2«88
Stood,
plaaaa
2699
U»er
BiposoRE ROUTE
AlaLTTICtL
KETHOD
Issanoenzysatic
cc
TIC
tadioeetry
CC
TIC
Badlosetty
laaunoenxyaat Lc
10HBER
or CISES
121
6
6
RUDE
6.6-27.* ug/100 al
0.009-16.* ng/el
a) 135-1* ug/al
b) 120-1* nq/al
c) 115-1* ng/al
d) 1*8-16 ng/al
a) 55-2 ng/al
b) 80-2 ng/el
c) 75-2.3 ng/al
A) 10-1 ng/al
lot given
8Etl
lot applicable
0.53 ug/al
a) Rot applicable
b) lot applicable
c) lot applicable
d) lot applicable
a) lot applicable
b) lot applicable
c) lot applicable
dj lot applicable
59 ug/100 eg
GEIIRKL tirOBIUTIOI
Tcilcology cans. Range for 3
solvent extcaction systess.
DBOGS; BILE; BRIII; LITER; KTDIETS;
CIIZEPIRS: BLOOC; IBISOSBBBII METHODS
Death caused by dcug coabinations
Records of 1239 deaths in O.S. and
Canada. In all, diaxepas oc its
setabolite «ece present in the
5-greatec than 65 yr. High frequency
of suicide. Other data available.
Pulsonacy and visceral congestion
sost eosaon postaoctea finding
DIOGS; DIOG IBOSE; CalaDa; OUTED
STJTES: OTtB; SED1TITBS; BIPKTICS;
fStCBOTROPIC DBOSS; BLOOD; LITEB;
IIDIETS; ILC080LIC BBTEI1GES;
ICREISTC HEDICTIE
a) Intca venous
b) Intraauacular
c) Subcataneois
d) Oral
Talees foe peak tin (<3 he) -2* he
after adsinistration. Subjects
received 5.1! 19 socphlne salfate/sq
a body surface, conjugated aocphine
• oEsal sen, eean age *9 yr, range
3«-«0 yr.
EICOD; aLKItOIDS; BLOOD PLlSCt;
DIOGS; 8ET1BOLI58
a) Intcavenous
b) latraauaculac
cl Subcutaaeous
d) Oral
Figures ace foe froa 15 ain-S he
•ttec adaioistcation. Subjects
received 5.75 eg aocphine sulfate/sg
s body surface. Free Mrphice
locsal aeo, sean age «9 yr, unge
3*-CO yc.
BLOOD; aLKILCXDS; BLOOD PLaSIa!
DRDSS; SBTIBOLISB
lexicology case
CROOS; BILE; Bllll: LITEI; KIDIETS;
CIIXEP1SS; BLOOD; HIlSOREBEIT BETBOOS
BErESEICE
Slightoa, E.I.
1978
rinkle, B.s.
BcCloskey, ic.L.
Goodaan, L. S.
1979
Brook, s.r.
Delle, H.
197*
Brank, S.r.
Delle, 8.
197*
Slightoa, E.L.
1978
-------
BorphlBBB-6-OM
BocphiBBB-6-oa*
76-42-6
C1B-I21-B-0*
•I 315.36. It 216-220 C
B,5alph«-«po»y-1«-hTdroir-3-B«tko«y-17-B«thyl- (8 CI)
' - |9
TISSOE
2690
plBBBB
BIWSOBB BOOTH
XB9**tloa
iBitmciL
BBTBOD
GC
BOBBEB
or ctsts
6
UME
•I 0-6.3 ng/Bl
b) 5.7-21.0 ag/Bl
c) 8. 5-36. 5 ng/Bl
d) 8.7-25.0 Bg/Bl
•1 7.3-11.9 Bg/Bl
f) 1.0-1B.3 ag/Bl
8B1B
a) 2.6 B9VB1
b) 13.1 ng/Bl
c) 18. • ng/Bl
d) 17.3 ng/Bl
•) 9. B Bg/Bl
f) B.7 ag/Bl
GBBIB1L XBFOBB1TIOB
B| 20 BlB
B| W BlB
e| 60 BlB
d) 90 Bla
•1 * or
d e BC
tEOfllU Bta.
BtBltky TOlantevcB.
OIOSS; BLOOD PUSBI; 8BIS01EVEBT
BETBODS; PBIISTLflllt
BBFBBEBCB
B«nil. I.L., Jr.
TBB. J.B.
1979
U)
ON
-------
qoiphlaan-6-ona, • ,Salpha-«po*r-3-kydto«y-17-a«thTl.- (4 CD
9orphlaai-6-on*. •,5-«poxy-3-hydroxy-17-a«thyl-, (Salpha)- {9 CT)
«66-99-9
C17-R19-I-O3
III 285.33. IP 266-2(7 c (cryatala (COB •thanol)
IISSOI
2691
Hood
2692
KldBay
2693
Line
269*
Or in*
KIPOSOI* HOOTE
-
Ing»tloa
miTTIClL
NETHOD
.. .
I»ano«nyutlc
IiianoMiyaatlc
I»ano*uyutlc
.
«vss
IORBB1
or cisss
S
L-
MIGR
lot gl*«n
lot glnn
lot givon
•1 0.5-«.6S of doi«
b) 3.2-6. 7S of 4o««
c| 0-2. IS of AOM
d) «.«-16.8t of do«*
•1 lot tppllnbl*
f) lot tppllcmbl*
HEtl
IT ag/100 il
12.7 ag/lOO 19
6.7 ag/100 19
t) 2.3X of das*
b) •.(( of dOM
c) 1.0*1 of don
d) 9.31 of do»
•) 1* of flow
f) 0.1S of dom
(•pprozlut«lr)
GEIIMl IIFOtUTtOI
Toilcalag; ct*»
oioos: BUI; mil; II»BB; KIDIBTS;
CIIIBPHS; BtOOIt niMORHBII HETRODS
TCliCOl09T C«M
DIOGSi BILE; Bllll; LITEI: KIOIBTS;
OlItBPHS; BLOOD; REISOIBIMI RRIODS
Tciicology on
DIOOS; BILE; Bltll; IITEI; KIDIBTS;
DIUBPtIS: BLOOD; RCISOIEHBI1 RITBOOS
• I 2 he. tl*f ton (3 «abj«ct»)
b) 2 kr. coBjag*t«d fora (3 rab)*ets)
c| 8 hi. fm (OCB (5 «abj«ct»|
d) B hi. conjagttcd fan (5 nbjw;t*)
•) Olhrdrolioiacphln* (••ttbcllt*) , 1
•abject
(I DlhrdioioiphliM (Mtabolite) , day
1
Iftac 9 hi, fn« tacm and«t«etabl« In
I of S »b]«ct«. conjugated fan
ditcetabl* at day 2 la 3 of 5
•object*. DOM, • 19, hydiochlocld*.
lUalthy, pclionvu, 25-46 jc old.
OIOOS: HBT1BOLISR; BETaBOLITIS;
IBtLOIStCS; OUIE
SErEHEICE
Sllghtoa. t.L.
1978
Sliqhtoi, E.L.
1978
Sllghtoi, ;.L.
1978
Con«, J.
Ph«lp», B.I.
Gocodttxkr, C.I.
1977
CO
-------
Bocpklaaa-6alpka-ol. 7,8-dldefcydro-»,5alpka-epoxy-3-nethoir-n-aeth7l- (e CT)
locpklnan-6-ol. 7,B-dld«fcyarc-».S-epo«j>-3-eatfcoKr-1''-«t»rl-. <5alpka.6alpka|- (9 CI)
76-57-3
C18-B21-B-03
II 299.36, IP loaokrdratle 1!«-156 C («ft«r drying at 80 CI
TISSUE
1695
Blood
2696
Blood
2697
Blood
269B
Benin
2699
ll»ee
EIPOSDBB BOOTB
1I1LTTICIL
•moo
laaanOeDtyeatlC
lananoenxyutlc
Innnnoonzynat Ic
IBIBBI
or CISBS
,
1
37
11KB
lot glTen
lot applicable
0.06-15.7 ug/Bl
lot gi»en
lot given
IBil
117 ag/100 il
0.2 19/100 ml
2.9 ag/nl
160 ag/100 ng
««0 ag/100 eg
8BIBI1L IIFOIBtTIOl
--
Toiicology «••
CIOOS; BILBj Bit II; LITBB; KIDIBTS;
DIKBMBS1 BLOOD; IB1SIBBRBB1 BBTHOOS
B«dlc4l «i>iliMC cu«a of doiths froi
iottotloBil ot accidental OD. oc
aidatocaiiwd oc natural causa.
DBOaS; iOTQPSIBSt BBMBXDXBIE;
BOXCXDBl BLOOD; OBXBBt UTBI; BILE;
CIOO 1BOSB
0«atk ca«a«4 bj dcig conbinatlon*
i«cocd* of 1239 death* In U.S. and
Canada. In all. diacapan oc Ita
aatabollt* >aca> pcaaant in tka
tinmen and. In noat caaea, tore than
one dcig enn found, tgee: laaa tkan
5-gceatec tkan 65 yc. Sigh fcegnency
of aalclde. Other data atallabla.
pilnonary and viaceral eongeatlon
loat connon poatnocten findirg
EBoast OBoa »BDSB; ciiaDi; OUTBD
!11TBSl OTkBi SBDaTIfBS; ITPBOTICS;
iSTCBonopic Danes: BLOOD; in IB;
(1DIBTS; 11COIOLIC BBTBBiGBS;
FOBBBSIC BBOICIIB
iciicology cane
CIDGS; Bill; BIUI; UTBB; KIDIETS;
ClltlPtlS; BLOOD; BBUOBBRBIt BBTBODS
Teslcologj caee
DSOaS; BILB; BBlII: IITBB; KTOItlS;
OIltBPkIS; BLOOD; BUSOIBBBBT DETHODS
BBPBBEBCB
Sllgkton. B.L.
1978
Siek. t.J.
1976
Pinkie, B.S.
BcCloeker. K.L.
eaodnnn, L.s.
1979
Sllgkton, B.L.
197B
Sllgkton, B.L.
197B
u>
-------
Bocphollne. J- ((2-ethoivphen«v| aethyl) -
(6817-91-1
C13-B«-»-fl3
"II 237.30. »( Bvdeochlorid* 1HS-1B6 C
TISSOJ
2700
nlood.
• hole
2701
Ilium
PIPOSOBr BOOTE
Infection
Ingextlon
tlALTTICIL
RETROD
CC
Raaioeetcv
GC
Badlocetrv
IOBBE1
or CaSBS
1
2
BtlCE
a) lot applicable
b) lot applicable
c} lot applicable
d) lot applicable
a) 3.7-10. 3X
b) «7.2-S7.9«
c) B8. 3-98. 3*
d) 91.3-103.0S
mi
a) 0.23 og/el
bl 0.35 ng/el
c) 0. 17 ng/el
d| lot detectable
a) lot given
b) lot given
c) lot given
d) lot given
GtllltL IirOSIUTIOl
a) 1 he
b) 2 he
c) 6.5 he
d( 12.5 he
level* bv
-------
lickal
1MO-02-0
II
1«« 0-02-0
II
Itf 58.71, IP 1*55 C, BP 2(37 c. ¥P 10 » Rg at 2090 C. 100 u 89 at 2370 C
TISSOE
2702
tdlpoaa
2703
lorta
270*
Blood,
plana
2705
Bale
EIP030IB BOOIB
Dacaal
inhalation
1IUTTICU,
BETBOD
I-cay apactroa
I-cay spactroa
US
11
IOBBBI
or CUB
3
*
a)
b)
c)
dl
•I
11
ItlGB
lot gi»aa
lot givan
a) 2.6-1*. 2 ng/1
b) *.6-13.* ug/1
c) 2.1-9.3 ug/l
d) 1.2-3.9 ug/l
•I 0.2-2.2 ug/1
«3-71 ppa
(IEIT
BB1I
0.19 ppa dcj >t
3.2* ppa dcr «t
a) 7.98 ug/1
b) 8.6 ag/l
c) *. 97 ug/l
d) 2.66 ng/1
•1 1.31 ug/l
57 ppa
PtCB)
GBiniL IIPOBUTIOI
Ibdoninal fat. 2 aaaplaa pac casa.
2 analyses par saiple.
197* aatopala* of 10 Plaa Intlau, a
Papago, and a Craak Indian.
poTassioii ctLcioH: iioi; COPPEI;
KlCi IBBIDIOB; IICIEL; LBlDj B8T1LS;
HiCB II.SBBBTS; LITER; SPLEBI; IO1T1;
KIDIEYS; aDIPOSB TISSOB; PMCBBaS:
BIISOBBIBIT BETBODSl IDTOPSItS
2 aaaplaa pac caaa. 2 analysis pac
saiplo.
197* autopaies of 10 Pisa Indiana, a
Papago, and a Craak Indian.
POT1SSIOB; CILCXOR; IIOI; COFPBB;
STIC; I08XDIOH; BICIBl; LEaD; BBT1LS;
I11CB UBHBI1S; IHBB; SPIBEI; lOBTa;
IIDIBIS; IDIPOSB TISSOB: PMCBEIS:
BIISOBBRBIT BBTBODS; aOTOPSXIS
a) lockeooi ale. 0.12-0.16 ng/cn a
k| lockcooa ale, 0.12-0.1* ng/cu a
c| lockcoo* ale, 0.05-0.07 ig/cu a
d| lockcooi ale, 0.03-0.0* •g/cu a
a) conteol iltk alniaal azpoauca
Concantcaticna obtalnad froi flgaraa.
Concantcationa in «orkara plaaaa
ColloKing 3 ak vacation. 0.0*-».0
•1/1.
] aalaa ag«d 29-30 ye. 1 faaala agad
•3 re and 1 contcol aged S3 ir, all
aiployad at alactcoplatlng abop.
BITItS; IXCRBL; BLOOD PLiSBl; OIIIB;
CCCOPaTIOItL BII1BCS; COBPtHITITB
IflLOtTIOIS; (DOLTS; PIIIIID
Scalp hale
Conoca fcoa 2 villagaa of laik*
Indiana in tin liaionaa Taccltocias
of Taaaxuala.
BUB; TBIBSOIU; HETaLS; TB1CB
BlIRBITS; SOD tO B; aLORIIOH] 5ILICOI:
CBLOBIIB; P014SSIOB; SCMDIOE;
tlTllIOR; TIUDIOl; CBBOBIOB; GOLD;
BIIOIIBSE; IIOI; COBALT; ITCRL;
COPP8B; XIBC; lISBITC; SELBIIOR;
IIORXIE: IOIIDIOR; STIOITIOR^ SXLTEB;
Hit BO II; IOCXII; CBSXOR; BallOH;
IIITRUOR; CCtlOR; SiHBIOB; REICaiT
UFBBBBCB
Baogalaon. I.P.
Bill, R.I.
lialaon, f.t.
Batoagh, D.J.
Chclatanaan, J.J.
Isatt. B.B.
Bicharda, D.O.
1979
Bangalaon, I.P.
Rill. B.I.
lialaon. I.e.
Batough, D.J.
Chriatanaan, J.J.
Ixatt. l.R.
lickarda, D.O.
1979
Tola. S.
Ulplo, J.
Tietano, B.
1979
Packoaa, I.I.
Tvlandia, J.J.
Dianas, B.
1977
00
-------
lickil
1MO-02-0
li
It* 58.11. IP 1*55 C. BP 2837 C, It 10 •• Bg at 2090 C. 100 mm 89 it 2370 C
(COITIIOED)
TISSUE
2706
Bale
2707
KldDIT
.
2706
KUniy
2709
U»ir
EIPOSORE ROUTE
tlalTTICal
SETBOD
BS
X-ray ipictcoi
ES
X-car ipcctcoi
IDBBEI
or cisss
at 126
bl 90
C) 71
d| 179
•1 108
(I 102
91 109
a) 9
bl 6
5
MICE
a) lot glnn
b) lot glTin
c) lot glmn
4) lot gi?in
•) lot gl»in
f) lot git to
9) lot giT.o
a) lot glrio
b) lot g Inn
a) lot given
b) lot glrin
e) lot glnn
Rot glr«n
BBal
a) O.SO og/g
bl 0.10 ug/g
c) 0. ""0 ag/g
4) 0.39 09/9
•1 0.79 «9/9
f) 0.«7 ag/9
9) 1.1* ag/g
Gioiitrlc ••an*
a) 3. as ppi dcy *t
b| 1.96 ppi dcy «t
a) 1.62 ppi (271)
b| 1.86 ppi (39X|
cl 1.82 ppi (3*«|
1.67 ppi tlj **
GtlttaL IIPOB!11TIO«
al Long laland chlldcin
b| gaiin* cbiUcin
c| Bronx childcin
d) Bali chlldnn
• 1 mail chlldm
f) Dal* adalti
gl r»al« adalti
Cocnlatloni bit«««n li and lk«
eclloilng: dmt eeiiailty location.
•ix. tddltlenal data.
Scalp dale. Caucailani in IT. «g«i <1
to gciatic than SI jr.
BtTllS; TI1CI ELCHIITS; 8IIIOB;
IOBOI; CkOBIOB: CHBOBIOB; COPPBB;
IIOI; LBtB; IITBIOB; BiiailllE;
anicoiT; IICKIL: siisiioa; SIITBB;
Til: HHDIOB; tuc; R»»: i«;
ICOLTS; CIILD1EI; SEX; COBPUiTIfB
ElalOHIOIS; OOSt) SOUS; >It
(OLLOTIOI; 01B1I tIMS; IBI IOBK
a| Hidnlla
b| Coctix
2 laipliB pic can. 2 analrm pic
inpli.
Saipli« froi 197* utopilis of 10
flu Indlani, a Pa page, and • CCMK
Indian.
pOTassiOR; catciOB; HOI; COPPEB;
1IIC; MBIDIOB; IICIBL; LBIO; BBT1LS;
TMCB ELBBBItS; LIfBB; SPLBBI; IOBT1;
(10IETS; IDIPOSB TISSOB; PHCIBIS;
BIISVIBBEIT BETBODS; iOTOPSIIS
a| lo cinil dlilail
ti tcvti cinal (allani
c) Chronic cmal tallacn
Dty "t bull
Piccvnt of aaiplii iltb ditictabli
Imli li Indlcitid In pacinthiMs.
litopilu at OCLl Boipltal.
TIICE BLEBEITS; BETUS; 10TOISIE5;
CILirOIITt; HDIETS; LItEB; SPLEEI;
OISElSBSi BTPntlBSIOl; SODIOB:
fCTiSSIOB; CIICIOB; PBOSPB010S;
BIGIESIOB; CIDBIOB; II 1C; CO IT El:
HID; IIOI; BalGUISE; iLOBIIOB;
SILICOI; TITIIIOB: COBaLT; IICCBL;
BCIIBDEIDH; Til; CHBOBUJB; S1BOITIDB;
I1IIOB; IITBIOB; SILT II; TallDIUH;
IOIOI
2 laipln pic can. 2 analrm pic
•aipli.
197* aatopllil of 10 fill Indlau. a
Capago. and a Ccnk Indian.
(OTaSSIOB; CitCIOB; IIOI; COIPBI;
tllC; IOBIDIBB: IICI.EI; llaD; BETltS;
1I1CE ELBBBITS! IITII; SPLBBI: UJBTJ;
IIOIETS; iDicosi TISSUE; PiiciEts;
BIISOIEBEIT BBTBODS; IOTOPSIIS
RETEBEICE
Craaion. J. p.
Blnnici. T.I.
Baigacnic, J.E.
Plnkicton. C.
1975
Rangilson. I.P.
Bill, B.I.
Ililson, U.K.
Eatoagh, D.J.
chclitiuin, J.J.
Izatt, I. B.
Ilchacdi, D.O.
1979
Indcapcailt, s.
lliiandic. o.».
Gonlck. B.C.
I97a
Bangilion. I.F.
Rill. B.I.
Illlion. K.K.
Eatoagh, D.J.
Chclitinnn. J.J.
Iiatt, l.a.
llchacdi, D.O.
1979
co
•>j
o
(IIXT PISE)
-------
Blckol v
7MO-02-0
It
Itl 58.71, at 1*55 C. BP 2837 C. TP 10 » 89 at 2090 C. 100 •• Bg «t 2370 C
(COBTIIOBD)
HSSOB
2710
tine
2711
lug
2712
laag
2711
Laag
BHOSOM MOTB
IULTTXCIL
IBTBOD
IS
BS
IS
its
•aim
or C»SBS
.
30
20
•1 129
b| 15
UMI
•I lot glTM
b) lot giT«e
c) lot gl»«n
lot datactabla-72.5 09/9
dry wt
lot glT«B
•) 0.5-5.0 ag/g dry «t
b| lot glT«a
(HIT
BBU
•I 1.85 ppa (1«*l
b| 2.1« ft* (391)
c) 1.95 ppi («*)
lot gifaa
». 3 ag/100 g dcr «t
•1 2.5 «9/g dry *t
b| 0.6 «g/g dry nt
PIGI)
GIIZIIL XIPOBBHXOI
•I lo natl
b) teat* c«Bal
e) Chronic CMil Cillacu
Cry «t b«>i«
Pccoit oC «upl«« ilth d*t«ct«bl«
!•¥•!• !• Indicate! IB pu«ntk«Ma.
litopslu at OCLl lupltal.
TIICI nBBMtSl UtUS) 1010HIB3;
CKXTOBIIas (IDIIT3) LIfBIl SFtEBIj
DXSBtSBS; BUBTBISZOli SODIOH;
(CtlSStOB; C11CIOB; tBOSPBOBOS;
IkBIBSnii CIDRXOH] IXIC; COtPII;
1110; XIOI; 1UBMUB; UOBIIOB:
SXIXCOI; IXTIIXOB: COB1LT; IICKEL;
BCUBDIIOB; III: CBIOBXOB; SnOltXOH;
HIXOB; LRIIOBi SXLVBI: TI1WPJH;
10101
Sections at I«n9« fcoi nbj«ct« «ko
had b*ao bltaalBOM coal Blaara tor
23-50 yc.
H»LS; tiici mains;
mini: Biimxoi: BOIOI; CIMBXOB;
CCPPBB; 8IBBIIXOB; 1801; Htl;
IkOIBSXOBj 8IIOMISB; IXCIBL;
sxixcoi: SIITEI; in; imiioa:
in IBS; CO»L; OIITBE STMBS:
BXIIUIS
Iiclndu appar and lonac lobu, aad
lyiph nod«i of lung. UUtieaal data
available.
SaetioBB of laaga fcoa labjactB who
Bad OMB bit«BlBoaa coal aintci for
12-50 yc IB lal*lgb Co«nty. Mat
flcglBla.
BITUS; TBICt SLtaBITS; COll;
BIinUOB; COBklti CBIOBXOB; COPPBI;
IIOIl J.BID; H6II5X08; SHOUBSE!
IXCKBL; TXTllXOB; flllOXOBl II1C;
10113; C08P«UTI?B BTlLOtTIOIS:
SIIICI; QOUTt; 1TEPB IODIS; IBST
TIIGIII1
a) Coal aioaia
b) COBtcola
SactloBB of laog* tcoa dacaaaad coal
alaan aad BOB-COB! alnac* fraa
lalalgh Coopty, loat Tlcgiaia.
8ETUS; TI1C! BLIBIITSi COH.; SXLIC1;
B1BTLLI08I CIMBXDIl COPPBI: IE01;
KID; ItOIBSIOl; HIIOHESB; nCKEt,;
IIIIIIOB; fumioB; siK: inns;
COBPIItTIVB IflLOkTIOIS; IIS1
TIBCIII1
HFBIIICB
iBdcapcaait. s.
IlasaDdar. e.T.
eonick. B.C.
197*
Ccabl*, J.T.
KMBBB, I.G.
(oloilci, P.I.
Kaatt. a.o.
Bolts. J.I.
Cocakl. C.8.
1967
U)
Kaaaaa, 1.6.
CrabU, J.T.
Saalliood, t.l.
Caclbacg. J.I.
1971
SlMt, D.T.
ccoaaa, I.E.
Ccabla. J.T.
Cacllwcg, J.8.
Lalnbart. «.S.
197*
-------
llckel
1MO-02-0
li
«tl 5«.71. RP 1BS5 C. 8P 2B37 C. TP 10 » Bg at 2090 C. 100 » Hg at 2310 C
(COITIIOED)
TISSUE
2"M«
Lang
2'is
Lysph
node
2716
Pancreas
2717
Spleen
EXPOSURE SOOTB
AMLTTICAL
RETBOD
ES
BS
I-ray spectcos
ES
IDRBEI
or CaSES
131
ID
3
B1IGE
1.8-5.0 ag/g dcy "t
lot given
lot given
s) Rot given
b) lot given
c) lot given
HEAI
3. 2 og/9 dcy «t
». 1 eg/100 9 dcy et
2.B6 pps dcy «t
a) 1.72 pps (16*)
b) 2.11 pps (38%)
c| 1.97 pps (40S)
CEIIUL IIPOHATIOI
lange of seans. Additional data
available.
sactions of lungs (cos deceased lest
licginia citsslnon* coal sinecs.
BETlLSi TPaCf ELEBtlTS; COAL; SILICA;
MRtlLIOH; CBBO1IOB; COPPEB; IROI;
HAD; RkGIESIOB; R1I81IESE; IICKEL;
TI1AIIOB; TtlaDIOH; II 1C; LOIGS;
CCBPtlaTITE tVALOlTIOIS: IES1
TIICIIIA
Pnlsonacy hilar lysph nodes (roe
subjects nao had been bitusicoas coal
sinecs (or 12-50 yr in Raleigh, lest
Virginia.
BITUS; TB1CC ELIRE1TS; COAL;
BEIYLLXOR; COBILT; CERORIOR; COPPER:
IROI; LEAD; BACIBSKJi; BAIGAIESE;
IICKEL; TITIIIDRl TallDIOR; 71 «C;
IOIQS; COHPlBlTIVB BfALOATIOtS;
SILICA; QOAITZ; ITBPB IODES; IEST
VIBGIIIA
2 sasples pec csse. 2 analyses pec
snsple.
147* autopsies of 10 Pisa Indians, a
pago, a disn.
POTASSIOH; C1LCIOR; IIOI; COPPER;
ZIIC; POBIDIOB; IICIBL; LEaO; RETlLS;
TIACE ELEREIIS; LITER; SPLEEI; AOETA;
RIDIEYS: ADIPOSE TISSUE; PAICBBAS;
BMSOIERER HBTRODS; AOTOPSIIS
a) lo re Dal dlsesse
t) Acute renal failures
c| Chronic renal fai laces
Dcy et basis
Percent of saaples «ith detectable
levels is indicated in parentheses.
Istopsies at UCLA Bospital.
TRICE ELEHERTS; REtalS; IDTOtSIES;
CALlrOHIA; HDIETS: LITER; 5PLBERS
DISEASES; BTPBBTEISIOI; SOOIOB;
POTISSIOB: CIICIDR; CROSPROROS;
RIGIESIOH; CADBIOB; tlK; COCPER;
HAD; IROI; BAIGAIESE; ALOBItOH;
SILICOl: TITAIIOB; COBALT; IICKEL:
BCLIBDBIOB; Til; CRMRIDH; SHORTIOB;
BIRIOR; LITRIOR; SILTEI; TAIADIOS;
BOIOI
SEFEREICE
Caclberg, J.B.
Ccable, J.T.
Listlaea, L.P.
lorrls, R.B.
Roltx, J. L.
Baaer, P.
Volonlcz, F.B.
1971
Keenan, B.C.
Crable, J.T.
Ssallvood, A.v.
Carlberg, J.R.
1971
Rangelson, l.r.
Rill, B.R.
liaison, K.K.
Estoegk, D.J.
CHt*l *T>s«na*a«fi I 1
1- Del. VCVDMD t il « J »
Izatt, B.H.
Richards, D.o.
1979
Indraprasit, S.
Alexander, G.T.
Gonlck, B.C.
197*
U)
^J
to
(IBIT P1GB)
-------
llctol
1MO-02-0
It
It
ati 58.71. 8P 1»SS C. B? 2831 C. fP 10 •• Bg «t 2090 C. 100 » Hg at 2370 C
(CORIIOBD)
nssoi
271 B
flcin*
Bifosmi BOOH
IXcaal
Inkalatlon
iniRXCaL
•moo
us
-
IOBBEB
or cists
•t
b)
o)
A)
•)
UMB
•t 30.0-120.0 ag/1
b) 62.0-93.5 ag/1
c) 25.0-96.0 ig/1
d) 9.0-40.0 ag/l
•) 6.0-10.0 ag/1
mi
•1 89. 6 ag/1
b) 78.3 «g/l
e) 56. S ag/1
d) 20.3 ag/1
•) 7. a ag/1
GBIItkL IROIBITIOI
•I lockcaa* lie, 0.12-0.16 ag/ca •
b| forkiooa «lr, 0.12-0.1* ig/ea •
c) lockcooc «tc. 0.05-0.07 ig/ea •
d) lorkcaoa air, 0.03-0.0* ae/ca •
•) control ultk BlBllal «xpo«r«
COBc«Btr«tiaa> obtilmd fcoi f lgac«>.
coanatcttlou in lockora' atin*
tcllailog 3 «k vacation! a.o-6.S
ag/1.
3 aaloa »9»d 29-30 jt, 1 f«aal« ag«d
•3 yr and 1 control ag*d S3 yc. all
•nploT*d at «l*ctr opiating a bop.
SETILS; IICIBL; BLCOD PLiSRa; OBIIB;
OCCOFITIOII1 BHiBCS; COUP Hit I TB
BfllOlTIOISi tOOLTS; FIILtID
urauici
Tola. S.
Ulplo. 4.
Virtano, 8.
1979
u>
-------
ItCOtlM (8 CI)
Pyrldine. 3-{1-aathyl-2-pTrrcUdlayl)-. (S) - (9 CII
Se-11-5
C10-B1H-I2
B» 162.23. IIP <-80 C, BP 2*7 C (partial dacoap) at 7«s •• 89, 123-125 c at I7 » (9. »P 1 •• Hg at 61.9 c
TISSUE
2719
Hoot.
plana
2720
Hood.
pinna
_
J721
Rreaat
fluid
tltosmi IOVTE
Inhalation
Inflation
Inhalation
IMLTTICIt
BETBOD
GC
OC
OC/BS
Selected Ion
recording
IOB BBS
or ciSEs
a| 10
bl 5
c) 10
4) 5
10
a) 2
W 1
e) 2
B»«GB
a) 15.5-10.7 ng/al
b) 23.6-18. a ng/al
cl 5.»-21.8 ng/nl
d) 6.1-10.6 ng/al
a) tot given
b) lot given
c) lot given
a) lot given
b) lot given
c) «6-60 ng/al
ncii
a) 26. S ng/nl
b) 38.2 ng/»l
cl 12.2 ng/al
d) 8.0 ng/nl
al 3*. 7 ng/al
b) 29.1 ng/al
c) 17.7 ng/al
-
a) 0 ng/al
b) 19S ng/al
e) 55 ng/al
GEBIB1L IirORIIlTIO*
a) r«aal«a 2 aln att«c cigar«tt«
b) Ul«« 2 aln aftac clgacctt*
c) F«aal«s «hll« taking 2 ag nicotine
gaa
d| Halu «hll« taking 2 ag nlcotln*
gga
Significant dl(f«c«no» b«t«*m aal*
and f«a*l<« aft«c clgarott*.
Iddltlonal data available.
Saokan. ag«d 21-57 TC. attending the
Baudalaf Boapital saokeca Clinic in
london. Onlt«d Klngdon
IXCOTIlEi BLOOD PlISBa; IOOMS; SIX;
COBPaRITtfl ITaLOtllOIS; OII1BD
(IIGDOR
at Pall-langth cigacettea
1) 3/*-l«ngth clganttea
c) 1/2-langth clg«catt««
If tar «B hr of •noklng ad litltaa.
aaaal brand, length of the tcbacco
colann altered aa indicated.
Significant, ?<0.001.
Saokera, 2*-65 yc old, aean cf 26.7
cigaret tea/day.
SBOKIIG; TOBtCCOS; IKOTIIB; IDOITS;
atcoD PUSBI: COBP»BITI»E
(1U01TIOIS; OIITED KIIODOB
_
a) lonaaokera
b) 2 packa pec day
cl 1 pack per day
stady done to datecalne ecponre of
breaet tiaaaea to ezogenoa*
agfcatancea.
lonlactatlng aonen
IIItLOIDS; IIUST) CHCIIOOBl!
BIBIUBt GUIOSi KCORIBi SBCKIK
SEPEBEICE
Basaell, B.4.
reyerabend. c.
Cole, P.f.
1976
Inaaell. H.l.H.
setton, s.B.
reyerabend, c.
Saloolee, T.
1980
Petrakls, l.L.
Groenke, 1. 0.
Bealen, T.c.
Caatagnoli, 1. , Jr.
Craig, J.C.
197«
co
-------
lltnt*
1*197-55-6
1-03
II 62.01
nssn
2722
OClM
iCTosmi IOOTI
Ing««tioi
IIUTTXCIL
RIMOD
Colorluttr
IOIBBI
or cuts
•1 "
W 23
MME
«) M)-<*0 ag/Bl
b) >0-<10 09/1!
-
mi
t) 10.7 ag/il
b) 3.0 ig/il
aniui inoiiiTioi
•1 Qalttcilli tailteits dclnUog
high-Rltc«t« *pciB9 ««t«r (high
c»c»i region)
b) Control! (COB Call (Ion cuc«c
c«qioi)
lite »ct«tlo> «lt hi* iBdlfllicU
ot«r tlM.
l«*U«nt« o< Coloibta team high «n4
Ion c«nc«c-ci*k r«gloai.
liniTBS; COlOIIUi "IIIBl IBDVUSRSi
CIIKIIG inn: cowuinn
IfkLDlTIOIS
uriuici
•••knocth. B.
mi. i.a.
eotauio. o.
cullo. c.
197*
01
-------
lltclc acid sodi.ua salt
7631-«9-a
8-1-03.Ha
II 85.01, a? 308 C
Ttssns
2723
Blood
272*
Kidney
27 25
Basel*
EXFOSOBE BOOTS
Ingestion
Ingest ion
Ingestion
lUlTTICkL
RFTBOD
Colorlsetry
Colorleetry
Colorisetry
IORBBB
or cisss
lot given
lot given
lot given
REtl
)0.0
10.5 19/kg vet vt
26 ig/ll9 vet lit
(•BIT P»GB)
lotopsy 5 he after death follovlng
Ingestion at estleated 50 9 la
nitcit*. Herat* and nitrite salts
not detected in bil«, *itcaois huaoc
oc lii«r (datvetlon Halt - 0.20
!«-yc-old nhita aal«, 78 kg.
Riccoscop7 c«v«al«d coB9*stion of
••ss«ls o{ tb« qastric Bocosa, Ian9s,
litac. aplaan, and kidasys, and
•itcavasation of atythrocyt«« of th*
gastric sacosa
90f of httsoglobin convsctod to
idttwaoglcbic.
IITBITES; »OTOPSItS; CtSE RlfTOBTBS:
BtBOOLOBIlS; BILK; BLOOD; KICIETS;
IITBB; IOSCIIS; STCBiCB; SOICIDB; IB«
StIICO
autopsy 5 hr aftvr death fol loving
inqestion of ratisatcd 50 9 la
nitcit*. litcat* and nltclta salts
not d*t*ctad la bll«. fitr«oos hasoc
cc liver (d«t«ction llslt - C. 20
31-yr-old (hits sale, 78 kg.
Oiccoacopy t««al«d congesticn of
•atiela of th* gastric aacoaa, lungs,
llnr, splsen, and kidnays, and
•itravasation of atythcocyt*! of the
gastric nacosa
90S of haaoglobln converted to
••theioglobln.
IRIITES; aOTOPSISS; C1SE BIStOIIES;
BEBOGIOBIIS; BIIE; BLOOD; HtlBTS;
iiTEi; aoscits; stcaaCBi SOICIDB: IE*
IHICO
aatopsy S hr after death (ol loving
ingestion of estimated SO g la
nitrite. Bitrste and nltrita salts
not detected in bile, rltreocs honor
or liver (detection liait - 0.20
3a-yr-old vhite sale, 78 kg.
Bicroscopy revealed congestion of
vessels of the gastric encosa, lungs,
liver, spleen, and kidneys, and
•itravasatica of ecytarocytai of the
gastric aucosa
90t of haaoglobln converted to
eethenoglcbin.
IITI1TES: aOtOPSIIS; CASE BISTOIIES;
BEBOGLOBIIS; BILE; BLOOD; HtlBTS;
LITE1: IdSClESi STCBICB: SUICIDE; IEI
BIIICO
Standafer. J.C.
Jones, ».B.
streat, E.
Inserra. p.
1979
Standefer, J.
Jones, a. a.
Street, E.
Inserra, B.
1979
U)
Standefer, J.
Jones, a. I.
Street. E.
Inserra, I.
1979
-------
lltclc acid aodlaa aalt
763I-W-*
B-B-O3.Ba
II 85.01. BP 308 C
(COITIIBBD)
WSSOB
2726
StOMCk
Eirosou loon
Ingcrtloa
tBunicu
IITIOD
colorlaatrr
BOBBEB
OF CUES
1
IllGE
lot givm
HBJ1
«8 9/fcg wt vt
OIltltL IITOIIMZOf
lltoplj 5 he «ft«E 4««th fgllovlBg
ligcstioa of ati»t*4 SO g la
oltrlt*. lltrat* ana •ttritt Mlta
aet d«t*ct«i in bll«. *itc*ow kaaor
oc li*ac (iataction 11 alt - 0.20
•1/1) .
3«-rr-oia lalt* a«l«, 78 kg.
lavaalad coagaitle* of
f«Mla of th* gastric aaco*a, long*.
lltar. «pl«*n, and kidneys, and
•itca»»«atloD of •rrthrocrt«a of th*
gaatrlc aacoaa
SOS of haaogloblD con»«rt«d to
••tkcioglobin.
40TOPSIES; CaSB BIStOlIES;
BHOCL08IIS; Bill! BIOOD; KIOIBTS;
IITBI; IOSCIBS; STCBICB; SOXCXDBl IBB
BIZICO
Stand*far. J.c.
JOBM. a.B.
StCMt. B.
Inaarra, t.
OJ
-------
litroua acid, aodlna aalt
1632-00-0
B-1-02.I*
III 69.01, HP 271 C, BP 320 C (decoap)
TISSUE
2727
Blood
2728
Kidney
2729
Basel*
EIPOSOBE 800TE
Inge at ion
Ing* it Ion
Ingeetion
aBlLTTICIl
H.BTBOD
Colorlnetry
CaloriMtry
Colorleetry
IDMBE9
OP CISES
MICE
lot given
lot given
lot given
0.55 19/1
0.50 eg/kg >*t «t
0.70 eg/kg «tt it
(IER P1GE)
GEItUL IirOIBlTIO*
litopay 5 hi after death folloving
ingeatlon of ostlnated 50 g la
nitrite, litcit* ud nltclt* Mlt«
not d*t*ct*d in bll«, *itc«oa hator
01 HT«C (detection licit - 0.20
• 9/1) •
3«-rr-old ihlt* ••!*, 78 kg.
lieroieopr t«»l«d coBg»tlcn of
ft lull of tk* gaitric «UCOBI, langi,
line. *pl**D, md kldaeys, ind
«ItC«M«tiOB Of •CrthCOCrt*! Of tk*
gotclc lacoia
90J of h*aoglobln cont*ct«d to
lithiaoglobin.
IITBUBS; IDTOPSIESj C1SB HISTOIIES;
BdOCLOBZIS; BILE; BLOOD; HI Of BIS;
IlfH; lOSCtJS; STCBtCB; SOICIOB; IBB
BHICO
titopar 5 kr after death following
ingeatloa of *atlaat*d 50 g la
nltcit*. litrate and nitrite aalt*
not detected in bile. »ltreoaa haaoc
oc liter (detection lleit -0.20
•9/1).
3«-ft-old ihlte Mle. 78 kg.
BiccoicopT repealed congestion of
•ttaela of the gaetcic aacoaa, longa,
liver, apleen, and kidneya, and
ettcavaMtlon of ecTthrocytea of the
gaetcic ancoaa
90S of keaoglobin conTerted to
a«tbeaoglobin.
HTBtTBSi lOtOPSIES; C1SE HIJI01IBS;
BEBOOtOBIlS; Bill; BLOOD; KICIBtS:
LIVEIi BDSCIES; STCI1CI; SOIC1CE; IE!
BHICO
Intopaj 5 he after death following
lageatlon of eetieatcd SO g Ba
nitrite, litrate and nitrite aalt a
not detected in bile, Titreoee hanor
or lifer (detection lieit - C.20
3«-rr-old »hite aale, 78 kg.
Blcroicopy revealed conge at I en of
veaaele of the gaatcic encoia, langa,
liver, epleen, and kidney*, and
eitcavaaation of erythrocytei of the
gaatric aacoaa
90* of heaoglobln converted to
aetheaoglobin.
IITMTES; IOTOP3IES; CaSE BISTOUB3:
BIBOGIOBIIS: BItll BLOOD; IICIITS;
IlfEII BOSCllSt SfOlaCB; SOICIOB: IEI
BIKCO
IEFEIEICE
standefer, J.C.
Jon**, «.n.
str**t, E.
Inoerra, a.
1979
Stand*f*r» J.r.
Jon*>, A. B.
Street, E.
Ineerra, I.
1979
CO
->l
00
Standefer, J.C.
Jones, a.B.
Street, E.
Xnnrra, B.
1979
-------
fltrou tcit, «ollu nit
1(32-00-0
B-B-02.B*
•I 69.01. SP 271 C. BF 320 C
(conxniD)
TISSOI
2730
Stouck
BXPOSOH torai
XngCOtiOB
•BU.RXCII
HITBOD
ColoclMtrr
IDBBB1
or CUBS
i
•1MB
lot gi»«n
•Ml
96 9/kg Mt «t
SSIIllL IIFOBBkTIOB
litopsy 5 he «tt«c d«*tb follovlag
ligutloi ot utility 50 g to
Bitclt*. Bltrat* ud Bitclti »Xt«
•c« not d«t«eted In U.1*, *tcic MCO«I. laag*.
llvic, tloa of «rythrocyt«i of tk»
9»tclc •acorn
90* of k««oglobln con»«rt«ij to
••th«ioglobia.
imiTU; 10TOPSIB3I CUB BISTOBIES;
BiBoaioBiisi BUB: BLOOD; KICIBTS;
HTBBi losciis; sTcatcB: saiciDi: BBI
BIfXCO
BiranBci
Stutoftc. J.C.
JOM«, 1. B.
Stn«t. B.
Xnwcr*. B.
1979
OJ
-------
• crzlallldU* (lo postUg« ID CHEIU.KP).
9lOOd,
plasaa
tltOSnt BOOT!
IPHttTICM
(IETBOB
HP 1C
HOHBBR
OP CiSES
15
HUGE
a) Hot gl»«n
b) lot given
c| lot gl»«n
d) Itot giime
•) 28»-1523 naol/1
HEAI
a) 663 » or - 50
niol/1
bl 882 • or - 90
naol/1
o| 868 » or - 8»
naol/1
d) 856 » or - 81
naol/1
•I Wot gl»an
SEiiut I«PO»IUTIO«
_ . ...
a) 1 vk
b) 2 »k
e» • "k
d) 6 «k
•) Dana* of iadlvldaal vala«i, first
•••k •icladvd
a)-dl rang* of a«ana
Do**, 200 aq/day, 6 "k.
idalt ln-piti«nt» Kith prlaaqr
10 of 15 aho»d c«dac«d d»pc«s*loa.
P«««c sld«-«ff«cts than "1th
DIOGSi DIOG IBEBJPI; BLOOD VUSUi
lITIDEPRESStfE IGEIT5; 1DDLT2;
CCBPlBlTIfl ETaLOkTIOIS; lEOIOtOCIC
IlllreSTaTICIS; PS 1C BO TBO PIC BBOCS;
01ITBD KIIGDCR
BCPB
Copp«n, i.
Eao, f.l.B.
S«ad*, c.
lood, K.
1979
00
o
-------
o-laiaaalda, !-H1-«thyl-2-pyeroU,dlByl|Bathyl.|-5-aalfaBojl- (8 CI)
BoBxaalda, S-(aalaoaelfOByl)-B-f(1-atfcyl-2-pyecolidlByl|aathyl)-2-a«tho*y- (9 CI)
15676-16-1
C15-B23-M-0«-S
•I 3*1.«. If 175-182 C (dacoap)
TISSUE
2732
Blood.
plaaia
2733
CanbEOSp
Inal
flald
ixposoiE Man
Ing* it ion
iBgaatioa
aiumcu
BETBOD
Flaoroaatcr
Ilk
IOIBBI
or CISES
12
6
BIIOB
0-2.2 ag/al
5-42 Bg/Bl
Hill
lot linn
20 Bg/Bl
aniML xiroiBMioB
Btin* b«to[« to % *k on 600 IJ/te7.
I»U«1 «ff«ct «tt«r 1 «k. tttlutod
fcoi graph. Back* 4 laUviditl
*ICl«tlOB. COCE4 »itk
[EolactiB, r-0. 73.
faychotic >oa«n ulth thoaght
41«ocd«c«, dclaaloBf, and aadltocy
ballaeiBatlou. lo organic train
dliocdar, loittic dlMaw, alcoholiaa
ot 4r«g abac*, igu 33 to 6? yr.
Sid* •((•cti Ineladca: alld
•xttapTraildal •(facts, t«asion IB
bna>U.
-------
ta*. a-a«l»o-S-cb.loce-I-{2-(di«thylaalnol«tkyll- ('
«, »-««l.no-S-chloro-l- (2-(4i»thTl«inol«
•«»-62-S
C1»-H22-C1-»1-02
•1 2*9. 11. (If Olhydcochlorida lonokydcat* US c
CI)
TISSUE
Blood.
pla*aa
EIPOSDI1! BOOTS
tug* ft Ion
kULYTIClL
RtTBPD
IOBBSB
OP CISES
11
BJWOB
a) 2«-1«7 ng/ll
b) »7-20» BO/il
a) ^1.3 » oc - 11.6
nij/il
b) 126.7 » oe - 14.3
•g/il
a
d
t
d
t
I
D
1
1
I
GIKI1L IirOBBlTIO
• I 3 he «£t«t 3 i 10 if/day (oc 28
days
t| 1 he aft«c 3 i 20 if/day (oc 28
day*
Patl«Dt*. ag«* 63.9 » or - 2.3 yc.
• Itk Idlopatbic packlnioniH.
Incccanj tc««oc do»«-c«lat«d.
DVOSS; OIOG TBHiPT; BLOOD PI1SH1;
ICC; KDOLTS; IEOBOBOSCOUB DISE1SES;
IIBTOOS SrSIBB DISUSES; OII1ED
III0001
lEfEIEICE
Bataun, D.I.
KahB, c.
1*19, B.J.
»«td, J.L.
00
S3
-------
01«*a-12-m-30-olc teld. 3b«t«-hy4roiT-11-oxo-, hydrogen soeclnat* (6 CXI
Ol«B-12-«B-29-olc «dd. 3-(3-c«rboxy-1-o*opropo*fl-11-o«>-. (3tMt*.20b«t*|- (9 CI)
5697-36-3
C3«-ISO-07
II ST0.7*. Bt 291-29* C
TISSOI
2735
11004.
Mrai
BIFOSOBB BOOTB
XBgcstiOB
lUlTTIClL
BETBOD
.
OC
IDHBIt
or casts
•1 12
b) 6
UB6B
•I 11-80 aa/ml
b) 14.5-21 «?/•!
_
OTH
•I 31 »9/»l
b) IB ag/kl
CEIIItL IIFOlBltlOl
•) R«al«d «lc*r«. Pati«nt
di((»r*Bc«a algni(leant
b) OahnUd «lc«ra
R»Ba ar« gtoMtrlc. Oroop »an
di((«r«BC«a highly algaificant.
19-63 yr old pitl*Bta with doodmol
«le«ra la loittalla.
slBgl* or BBlttpl* controllabl* ald«
•((•eta of: hyp*rtcnalon, «tight
gain, •4«ial hypokalcaia. 19 of 20
had rad«cad BMd (or aatacidi. Olccc
greater than IB control!.
DIMS; D10G TBBBkPT: StOOD SMOB;
1DOLTS; COBPIBtTITI ITIL01TICIS;
GISBiSBS) »aST»lLI»! OlStlOIttBSTIUL
SISTBB; UTI-nrLIBBiTOBT iGdtS;
HiLGBSICS; BIPBIIBISIOIl STIBOXDS
BBTBIBICB
ToBBg, e.e.
St. John. o.J.B.
CorcBtrr, D.i.
1979
CO
00
Lo
-------
p-Acetophenetidide (1 CT)
tcetaslde, l-(e-etho«yphenYl)-
62-M-2
C10-R13-1-02
91 179.21. DC 13«-1»5 C
C> CD
TTSSOE
2136
Blood.
plassa
2737
Blood.
plasaa
273*
Orine
EXPOSOi; BOOTS
Tngestion
Ingestlon
Inflation
AlfALITIClll
BETBOD
an
TIC
oc/as
TIT
cc/>is
ItJHBSB
or CASSS
19
T
7
BAIGE
a) 100-760 ng/nl
b) HO-735 oq/il
c| 222-0.21 ng/il
d) 42-0.80 ng/«l
«| 0.27-1.3 ag/il
b| 2. • 1-1. 06 ag/»l
2.6-11.3 «g/2« hr
1!H
«) lot given
b| lot glren
cl lot given
d) Not given
» 0.113 ag/*l
b) 3. l» ag/il
lot given
TCIIBtL IirOBIHTICl
i) TIC. ccccelation coefficient 0."9'>
•ith RIt, 17 volunteers, 325 «g
b) »H, correlation coefficient 0.«97
•Itb TLC, 17 volunteers. 325 ig
c) One lale, 1 hr (peak) -12 Ir after
2!0 sg. III
d) One »ale 1.67 ht (p«ak)-U be
•fter 2SO eg, RT>.
D10GS; DBOG TREIIPT; IOBTB ClSOtlll:
BIISOBBH8VT BETHODS; BLOOD PIIS91;
COGS; COBPllaTIVE ET>l
-------
p-D10xan |8 CI)
1,a-Dloxan« |9 CI)
123-91-1
C«-IB-02
ii as.10. ir 11.10 c. BP 101.1 c, »p «o •• 19 «t 25.2 c
TISSOE
2739
Blood.
plain
27*0
Orln*
BIMSOU I001B
Inhalation
Inhalation
aElLTTicil
•ETIOD
sc/as
GC/BS
IOBBBB
or cases
a
«
BIIOI
a) lot gl*«n
b) lot gl»«n
cl lot 9l»«n
d) lot 9l»«n
2.71S-».2B7 09/12 kc
BBkl
t) 1.2 «9/«l
b) 8.5 ag/il
cl 12. 5 09/1!
d) 0.25 H9/«l
3233 09/12 kc
GEIIUL IIFOB51TIO»
a) O.S kc
bl 2 kc
c| 6 he
d) 12 he
Daclng and «(t«r 6-ht •xpomn to SO
ff"-
B*althr ••!• nbjact* (Man »9« *«
jc, ••» nalght ea kg) .
C;« Iccltatlon dacing •ipoiara.
DIOXklBS; BLOOD PLISSl; OBIH;
BtTkBOLITBS
Total «cc«tlon< 6-hr •ipoaom to SO
((•. B*ta-kTdcoxr«tkoxrac«tic acid
••tabollt* also (•aaoccd.
Kalthy aala subjects (a*an >g« «»
jc, a«an ••i9ht 6» kql .
tj* Iccltatlon dacln9 •xpoiuce.
CIOXIIBS; BtOOO »L»U; OBIHI;
•ITtBOLIIBS
IBPBIBICB
Toang. J.D.
Bcaan( I.B.
Baapyv L. I.
Chano««th, B.B.
Blan. 6.B.
1977
10009, J.D.
Bcaun, >.B.
Kaapy. L. B.
Ch«nov«th, B.B.
Blaa. G.E.
1977
oo
-------
p-Hfdcoirphanylacvtlc acid (»o poatloga in CIBKLim.
TISSUE
oelne
EIPOSOBE BOUTE
Ingaatlon
immciL
IHTROO
GC
iOSB-9
OP CISSS
«
BIIGE
a) 10.3-2«.« ag/2« he
b) 1».5-22.» ag/2« he
. -
1C»S
,
a) IB. 7 aq/2« he
bl 20.0 ag/2« he
GEIEBtL IIPOBHtTIOl
a) Standard deug fccnlatlon
t) Delayed ataocption tablcta
Doaage 2.5-3.5 9/day lavodopa.
2 aala and 2 teaale packlnaoclan
patient! aged 61-66 ye.
Gaateolntestlnal aide effecti vita
delayed celeaae (oca.
CtOOS; KETIBCLITES: OtllE; OIITEO
•IPGDO1
-
BEPEBEBCE
Sandlac. H.
Bnthnn. C.B.J.
Goodvin. B.L.
Butac, K.B.
Staca. G.H.
1«7a
00
ON
-------
ihm«thri»iM (a a)
B*»«M*th»uia« (9 CI)
c«-o«-o
CS-B11-I
II 121.18, •» 19*. 5-195 C
TXSSVB
Z7«2
Blood
tiumcai
BRIOD
lOHBBi
OF CUBS
1
UNI
lot *ppllc*t>l«
nti
280 If/100 ml
OIIII1L XH01IHIOI
._
••dlcal •»ila*r cu» of 4«itk* {COB
litvatiOHl or accid«nt*l OD. oc
gDd«t«ciio«d oc natural causa.
Dines i mtopsiBS: BBPBIIDIIIS;
SOICIDB; BLOOD; aillli UTBI; BUB;
nine JBOSB
UFBU1CB
Si«k. T.J.
1978
00
-------
Phenethvlaeinr. alpha-eethvl-, (»-) - (8 CI|
Centeneethanaslne. alpha-net by1-, (»-l- (q CI)
300-62-9
C9-R13-I
II US.20. 8P 200-20) C at 7(0 » 1*9, 62-85 C at 13 •• Hg
mood,
plasaa
Saliva
EIPOSORE ROOT!
Tngestlon
Ingestion
alALTTTCkL
RETROD
BC/HS
GC/4S
•DRBEI
or CJSHS
BklGE
a) 31.5-6.0 ng/el
bl 32.0-10.5 ng/sl
a) 110-13.S ng/nl
b) 120-30 ng/»l
a) lot given
bl Mot given
al Hot given
b) lot given
CEIIRH TirORIUTIOII
a) 1 and »" he afttc 10 ng
(•l-aaphetaiine vith laRCO). Initial
•al<», 21 ng/il at 0.5 hr
M 1 and 18 he after 10 ng
l-)-a«phetaelne «lth MHC03. Initial
value. 13 ng/el at O.S he
tatliated (cca graph. Data available
(cc doae as raceilc aephetaeine vith
acid and basic nrinarv pR.
3 aales and 1 feaale, ages 23-26 jc.
CIU1S; KllSaS; (DOITS; BLOOD PLaSBt;
SILTT«; OBtlt; CODPllkTITZ
tmOATTOIS: KETaBOlISH; PSICROTBOPIC
CBOdS
I) 2 and »8 he attec 10 eg
(•)-a«phetaaine vith laRC03. Initial
value, 69 ng/al at O.S he
c| 2 and *8 he attec 19 ag
(-)-aaphetaeine vith »aRC03. Initial
valae. 6~> ng/el at O.S he
El Heated Ccce graph. Data available
(oc don a« caceeic aephetaelne «ith
acid and basic ucinaey pB.
3 sales and 1 Cesale, ages 22-26 ve.
CvOSS; KalStS; tDOtTS; BLOOD PLaSM;
SILITt; DRUE; COHMBaTTTt
Ef«LO>TIOIS; HETaBOLISfl; PSTCROTBOPIC
CFOOS
Ian. S.H.
fiatin, S.P.
Azacnoff, D.L.
Han, S.H.
•atln, S.B.
azacnoff, D.L.
1978
CO
00
00
-------
PbanatbrlaalM, B-«tbyl-alpba-a«tbTl-«-(tnfl*oeo»«tbyl|- (« CI)
Bmzamtbaaailm, B-»tb7l-*lpha-«atbyl-3-ol*>t*«e«.
CBDGS; BLOOD PL1SBI; tTUT
BJtnBBBCB
cacattlBl. S.
caccla, S.
1979
U>
00
VO
-------
Fhenol
10«-«5-2
ce-16-o
II 9*.11. IP HO.SS C. BP 112 C, »? 1 » H9 at «0.1 C
Oclne
Ociae
8 IPO SO fif PODTB
Ingvvtlon
Tng««tlon
fcVALYTXCIt
1BTHOO
GC/BS
OC
•OIIBt*
OP CASK
1
1
URGE
Not applicable
a) lot applicable
b) Rot applicable
c) lot applicable
d) Rot applicable
e) lot applicable
f) lot applicable
1E»I
13.8 ppa
a) 260.0 ppa
b) 5.5 ppa
e) 25.0 ppi
11 0.5 ppa
e) 10.0 ppa
f) 1.00 ppa
REKIIL IlfCBIiTIOB
Cestlcide (ciaoning.
PISTICIDBS; OIIIE; OBfJUOPBOIPHHTES;
BICOD: LtTtI; BBIIR; PBEIOtS; MSB
BISTOBIES; IORB CIBOLIR*
a) Peak total phencl " he aftec
P«pto-Bi«.ol foe 9 he at 28.25 9/fcc
b) Total phenol to he after
Vepto-flsiol for 8 hr at 2«. 35 j/»r
c) Peak feee phenol « hr after phenol
lallcflat* (or « he at 40 ag/tir
dl Tree phenol 72 he aftec ptenyl
aalicflate (oc 9 he at °0 ag/hc
e) Peak fcea phenol n he aftec 1
cblocaseptic Ioxen9e aveey 2 he foe
U he
f) rcee phenol 61 he aftec 1
choraMptlc Imenge e»ecy 2 he foe 16
he
49
-------
•-(2-Mlma*thyl|- (8 CI)
fhmal. 3-<2-Hlalth
dalayad c«l«as« toes.
HOBS; HBTaBOLITBS: DIIIB; 01ITBD
IIIGDOH
BETEtBICB
Sandlar, B.
patbna, c.l.J.
Goodwin, B. L.
Hantac, K.B.
staea, G.B.
-------
Chenol, p-»lno- (" Ct)
Ph«nol, i-aslno- (*> CI)
123-30-9
tf-tn-t-o
HI 109.12. HP 119.6-190.2 C, couerclal 186 C, BP 210 C (decotp)
TISSUE
27«9
Oclna
EIPOSIIII1! ROUTE
Tn9««tioD
««»tnicM
SCTHOD
,
•OflBEB
or casss
6
BINGE
Not given
KEHN
21.CH
_
GE»EB»L IBPOBflATIOII
fiilOO mq tablets of phenazopjcidiae
bydcocblocide. < of dose ID Z4-hr
ocine.
f> healthy ialesf aged 25 to 40 yrs.
C803S; KETABOLITES: UBIHE; CINlDt
8EFEBEIICE
Johnson, w.J.
chartrand, A.
1976
.
-------
Pbinol. p-nltro- (8 CI)
pb.nol, «-nltro- (9 CI)
100-02-7
CC-BS-l-03
Bl 139.11. IIP 11*.9-115.6 C. BP 279 C (flccoip)
TISSDE
2750
Ocln*
BIPOSOHB BOOTB
Ingcatlon
IHLYTICIL
HZTIOD
GC-BC
IOHBEB
Of CaSBS
«
.
BIIGB
a) 0.08-0.20 19/1
b) 0.16-0.61 >9/l
C) O.OH-0. 11 «q/l
d) 0.10-0.30 ig/1
(IBtB
a) 0.13 19/1 (0.29
•9/2« he)
b) 0.3* If /I (0.5S
19/2» he)
0)0.06 19/1 (0.13
•g/2» he)
d) 0.17 19/1 (0.30
mg/2> he)
OBIJBIL IBPOBHITIOB
a) 2 19/day of ••thyl pacathioa
b) 4 B9/day oC ••thyl pacathion
c) 1 >9/dar oC ethyl parathlcn
4) 2 «q/d»y of «thyl pacathicn
PCSTICIDBS; OHGaVOEROSPRaTES: OBIBB;
BETABOLITBS; IOS1; PBEBOLS
BEFZBEBCE
Bocgan, O.P.
Betzlec. B.I.
slack, B.r.
Lin. L.L.
1977
Co
-------
rkeaol. peatackloro-
«7-»«-S
c»-»-cis-o
It 261.35, IP 19fl-1«1 '•-. BP 30*O10 C (d*coep| . T» aO •>
at 211.2 C
TtSSVE
%dlpose
Id 1 pose
Blood.
plSSM
Blood.
s*r»
ETPOSOIE fOOT*
mimciL
OBTIOD
BC-BC
ec-ec
ec-ec
riiBEt
or c»s is
25
13
a) 23
b> 23
ft 1»
a) 33
b| 25
IIKE
lot detected - 0.57 ppa
10-80 ppb
a) lot gives
b) lot give*
c| lot gives
al 10-98 ppb
•1 11-120 ppb
c) 10-91 ppb
d) 11--M ppb
BUI
o. 1% » or - o.o« rp«
23 ppb
al «.»« ao/1
b) 1S.*« aa/1
c) 15.00 ag/1
al 29.12 • or - 1S.7
Pfb
b| ••.•« • or - W.5
c| 29.TS • or - 2».3
PPb
dl 35.0 » or - 20.2
PPb
_
CBIEHL xirnvHiTioi
• ci-occapatioaal eiposere. Halt of
dctectioa 5 fpb.
Idlpos* tissee via Mdlcal eiaaisers
at hospitals U Kyoto asd Osaka is
19">«, cklldrca asd adelts.
Jirti: riRtcBioBonnoL; pvnois;
CltOIIIkirO ITDIOClIBOU; IBITOS!
TISSUE: iistcnciots; pncicnes
laterlor abdcsiaal >all tlssa*.
latopsios by eadical cxasiset, 9ade
Coaaty, PL
CBIOIIIE OISMIC COBP08TOS;
ICRkCMOfOPmOt.: BIOOD SE10R;
itiposr TissBE: meiciors; IESTICIDE
BisiovES: iicnok: lororsiis:
BIISOIE^EIT IRIODS; 01IIIIIC WsTEl;
ItOtTS
al Patleata os keaodialysl* for
ckrosic cvaal failere. predialysis
b) Petlests os keaodia lysis tor
cl Coetrols
PatUats at Ckacity Sosplul is Be*
ocl*ass, Loeislaaa, aid relatives of
catiests (costrols) or sorkecs at tke
•sit (coatrols)
rtsncTocs; BLOOD ruisu; toeisiiik;
DtE; OR: riRICBLOIOPBnOL
a) City »ter ssers
c) Siboraep. 12 city cater asers la
a|. 10 «ltk detectable Mter levels
111'. 2 pic* or sises 88. "» ppt]
d| Smborosp, 10 sell vst*r sssrs is
bl. S »itk detectable rater levels
|««.S » or - 23. » ppM
Halts ot detectios: ester 0.3 ppb
ieres 30 ppb.
58 >kit* (esales. Bad* Coaaty PI.
•eck «itk drisklsg essee patters > 5
CUOIIIE oicinc coBtoms;
EIRlCltOBOfllSOl: ILOOB SCBIH:
kllfOSC IISSSB; FSKICIDES: nSTICIDE
lESTBfES: fMBIM; kOTOPSIBS;
iiksOBBBin iRiois: Dnnnc itrit:
IMLTS
"""*"
Ok*, T.
19T9
(orosde. c.
Baroeet. a.
Pfaff*ab*rqer. e.g.
19M
Pearsos. J. E.
scksltz. C.D.
tirers, J.t.
Coazalex. »-5-
19^6
.
Boroade. C.
Bsrqeet. 1.
Pfaftesberaer, C.D.
1980
U)
VO
-------
faeaol, 2.2*-aetkTleaebl«|3.4.C-trlcUeco-
70-30-*
C13-I6-C16-02
II *0t.92. It U*-1*5 C
YISSIE
2755
Blood
.-
27S«
Blood.
plana
2757
Blood.
«kola
275«
lateoeaaa
t
BiPosoBz BOOTS
•anal
lagestloa
Oereal
Deraal
tULTTIClI.
irnoo
OC-BC
sc
Badloeetrr
BIBBBB
OP C1SBS
a) *3
M 10
d ie
1
al 166
b| 3*0
O 32
6
BIKE
al 4.0-11.0 ae/al
M 630.7-395.* •g/Bl
c) 655.3-330.8 ag/al
00-50 ag/al
al 0.280 • or - 0.295 to
O.TM « or - O.aoo aaol/1
b) 0.122 » or - 0.10; to
0.161 » or - 0.183 aaol/1
c| 0.159-0.220 aaol/1
. „.
a) 0.070-C. «T? ag/*q ca
b) <0. 00 1-0. 1->C a9/*9 ca
BUI
al Bat glTea
bt Bot applicable
e| Bot applicable
lot glna
>| >0t glna
b) lot glvea
c) lot glvea
a) lot glvea
b| lot glrea
CIIEB1L ISTOBUTIOI
a| Baage of aaaa laltlal levels
before ealag pIM nbaj or Bypsrphase
tl Peak (at *| aad 0-ak valee for
pBlaokez aaaaa
c| Peak (ak •) aad 0-ek valae for
Byparpkaie aaaaa
Bally caaplete body aaaalag, 3 ale.
30 al coatalalag 900 mi
kezacaloropaaaa, taaa daae, dariag
8-ak period. Lanla ratanad to
aoraal 2-3 ak after aadlag aaa. Bo
age. aax, body aelgkt. or race
effect*.
Idalta altkoct skla or ayatedc
lo adveraa ayctaalc effect*.
iiiicnoiopBeiB: i DOITS;
EIOlCCIIICllTtOI; CCINI1T1TI
MUlaTIOIS
ta*ela 2* aad «8 kr after laoaatloa.
respectively. lafaat accidaatallr
fed 10-15 el pBlaooai (100 es/kg
•aucklocopaeael aas later adalttad
to boapltal for gastric aasklags.
• day old. 2,800 g* Paerto Xicaa.
Iceltlag. dlarrkea. dekydratioa.
lethargy, pcoc reapoaae to palatal
atlaalatloa, facial teltcklag.
accaataated tllaklag, ezaggaratad
itartla reapoaaa.
I«I: IBtSOBl; BMOC PtlSBl; C1SB
IISTOIIES; CBLOBIIE OBC1ITC
CC8POBIBS; KUCBIOBOPBIIE:
ItHBOMCIC BIBtPESIKIOIS;
ItSSlCBOSCTTS
a) laage of eeaaa. 382 speclaaas
froa 1-10 day old lataata aadargolag
coatlaa akla care altk pllsoaas (3. Of
kacacaloropbeael
t) taage of aaaaa. 3-7 day eld
iafaata andergolag roatlae side care
• Itk pIlseBei (0.75% kexacklcropkeaei
c| laage of aaaaa. letboras poadarad
3-ia days aita O.Sl kexacklozopkaaa
talc (*. 5 ig/d«rl
OIISS; lEIlCilOIOriEIC: BLOOC;
IIP1ITS; lEieOII; laStBlLIl
a| 10 ala
It 2 days
aclderata attar aaaklag oltk 9^
coavantloaal aoap saspeaaioa or 10%
cca-aoap detargaat.
DI07S; DBOOOIIITS; S(II
I1TEUICE
Calaaalck. B.
Coctallo. C.I.
Byaa. J.p.
BLBragorlo, S.J.
1975
Barakoaltx, J.
Boaaaa, I. p.
1979
Plaackkaka. T.D.
tallard. B. 1.
Baa la. J.a.
Colllas. B.B.
rlett, P.I.
1^78
Black, J.6.
Sprott. I.E.
Petkerford. T.
ma
OJ
\o
Cn
-------
Fhenol, 2,3.«,S-t««uichtoco-
•901-51-J
C6-B2-CH-0
HI 231.59. It 116-111 C
Tissnt
J159
tdlpoae
Blood,
aeraa
EXPOSURE BOOTE
... . ..
1MLTTIC1L
HETHOD
GC-BC
GC-EC
or c»s;s
10
B.IGJ
Rone detected
(one detected
.....
Jon« detected
lone detected
GCIIBtL IBPORHITIOK
Halt of detection 0.1« ppi
•otopaiea tj aedlcal exaainei, Dade
Ceantr. PL
CCL9BTIE OBGIBZC CCHPOOBDS;
FtlllCBLOBOPBBBOl: BLOOD SEBUM:
ICIPOSE TISSOB; nBGICIDES; FESTICIDB
BisiDOBS; ricitoi; IVTOPSIES;
attSOBEHBBT BBTROOS; DBTBKIBG HHTEB;
ICOLTS
Unit of detection 0.08 ppi
56 Khlte teaelea Dada Coantf PL, each
•1th dciaklDf *atec oaage pattern > 5
CBLOBIIB OBGIBIC CCIPOOTDS:
EtBTtCHLOBOBtBOL; BLOOD SEBVH;
IDIPOSE TISSOBi FOIGICIDES: RSTICIDE
•ISIDDESi flCBIDti 10TOPSIES:
BttSOBBHBBT HETBOOS; DBIIKIBO »»TEB;
•COLTS
BEF!B«CE
Bocqade, C.
Parqoat, i.
Pfaf fenbecgec, C.D.
1910
nocgade, c.
B«rq»et, 1.
PfafCenbecgec, C.D.
1980
u>
VO
-------
Ph«ol. 2,3,«.6-t«tE«ehloco-
58-40-2
C6-R2-Cl«-0
R« 231.9. RP 69-70 C. 288 C fdceoip). It 1 •• Sg «t 100.0 C
TISSUE
2761
UlpOM
2762
Blood.
MHII
BIP050BB IOOTB
1MLTTIOL
BETBOD
GC-BC
OC-BC
IORBBI
or C»SBS
10
58
IUOE
Ion* t«t*ct«4
IOD« det«ct«4
,._. , -ffiu...
Ion* 4«t«ct«4
Ion* A*t«ct«d
OBIBUI. IIFOIBlIIOi
tlilt of d«t«ction 0.09 pp*
>gtop«i«* by ••dlcal •n«in«i> Dtd*
CcontT. rt.
CBIOIIIB OI8HIC CCRPOOIDS;
PHTkCRLOBOPBBIQlS BLOOD SHOT:
1DXPOSB TISSOB; PDIOICIDES; EESTICIDE
B1SIDOBS; riCIIDl; 10TOPSIBS;
BMSDtBBBIT BETBODS; DIUKIIC IITBRi
•COLTS
Halt oC d«tactlon 0.0* ft*
56 «hU» <•••!•• D«d« coiatf. ft,
••ch with dcinklDq »«t«r aug*
[Btt*n > 5 yr.
CR108IRB OBQIRIC CORPOOIDSt
fBRIICRlOIOPRBROll BLOOD SEIOB;
IMPOSE TISSOB; POBGICIDBS; RSTICIDB
RISIOOBS; ItCtlDl: iOTOPSIBS;
HIiSaBBIIBRT BBT80DS: DRIIKRC IITEB;
1 COLTS
UFBRBRCB
Borqmd*. C.
Birqtut, I.
PftftenlMrgK, c.D.
1980
Bocgad*, C.
BarqiMt. I.
Pfot(*nb«cg*c. C.D.
1980
U)
-------
•k*nol, 2,3,5-tclchloro-
933--H-8
e«-HJ-Cll-O
SI 19^.»S. HP 62 r. HP 2*8.5-2*9.5 at 250 •• 19
TISSOU
2761
Idipoae
216*
Blood.
•era*
2165
Blood.
•era*
BIPOSOBS BOOTB
IRILTTICIL
RETROD
OC-BC
OC-EC
,
OC-EC
«
RORBSB
OF CaSBS
10
SB
r
SB
IlIBE
•Bon* detected
...
•on* d»t«ct*d
Bon* detected
REAR
Boa* detected
lone detected
Bone detected
GEIEBIL IIFOMITIQI
Uilt* of detection 0.2* ppn
latopales by eedlcal ezaalnec. Dad*
Cconty, PL.
CBLOBTIB OIGIIIC CCHPOORDS;
ClBIaCBLOIOPBBBOL: BLOOD SBBCR:
IMPOSE TISSOS: POBGICIDESs IESTICIDB
BISIDOES; FLCSXDI; IUTO?SIES:
maSOBBRBBT BBTRODS: DIIIIIIG IHBS;
ICOLTS
Halt of detection 0.10 ppi
se iklte t*iale«. Dade Count I FL,
•ack iltk dc Ink log later aiaoa
pittecn > 5 yc.
CRLOBTRB OBGIBIC COSPOOIDS;
ttlUCBLOBOPBBIOl; BLOOD SBIOH;
IDIPOSE «SSOE; FOIOtCtDESj RSTICIDE
ItSIDOBS; FLCBID1; 10TOPSIES;
RIaSOBBRBBT BBTRODS; DBIBIIIC ItTEB;
1 COLTS
Halt of detection O.^B ppi
;e >kite f*iale«, Oade Count) ft.
•ack iltk dclnklnq vatec lease
patten > 5 yc.
CBLOBIBE OBOIIIC CORPOOIDS;
PIBTlCRLOBOPBEBOl: BLOOD SE10H;
IDIPOSE TXSSOE; PORGICIDESi FESTICIDE
BISIDOES; FICBID1; aOTOPSIES;
BttSOBSREBT BETHODS; DRIBKIBG «»TEB;
1 DOLTS
BEPEBEBCB
FOC9ade C
Bacqoat, t.
Pfa(fenb*r9*c. C.D.
1010
Ror9ad*, C.
Batqtwt, I.
Pfaff*Bb*C9*c, C.D.
1980
Hocqad*. C.
BacqMt, a.
P(atf*nb*c9*c. C.D.
1980
U)
SO
00
-------
Pkraol. 2.a-dicaloro-
120-83-2
CC-B*-a2-0
H 163.0. IP «5 C, tt 209-210 C
TISSUE
2766
Idlpose
2-WT
OrlM
BXPOSOU 100TB
1I1LTTICIL
BBTBOD
-
GC-BC
OC-EC
BOBBBB
or CUBS
10
-
2
BUGS
Ion* detected
...
27»-1.1 ppa
ma
Bane detected
fat applicable
SBIIUl IEFOBBMXOE
Halt of d«t«ction ».69 ppa
litopala* by a«dleal •uaiiMC, IMi«
CoantT. fl.
CILOIIIE oiatnc coiponosi
IIIMCBUMMMOt; BLOOD SUCH;
IDIPOSB tISSOE; FOiaiCIDES; CBStXCIDE
1ISIDDES; riQIIDt; aOTOPSIBS;
8IISOIBBBR BBTBODS; D1IIKIIG IHEI;
IDOLtS
Cttnq*. 1 to 3* 4aya after 170. 1-9
laja*tloi of 75 t dicblofaothion by a
C2~yr-oli.
SoietAal iagactloa.
Slo« on»t aod •Tolitlon of
ckoliavcflc ayaptoa*. 0*c«pUr«ly
illd Initially, la tat Mrara B
llf*-tbc«at«ninj do* to rvapiratocy
aabarcaaaaaot. Pcotcactad, using
aad tailing clinical cones*.
Dalayad onsat of caapicatocy
iaaafflciancy and otkac ckolinarglc
affects. Bleeding fcoe the CI tract.
bypokalaaia, alld ancaphalpattiy.
SOICIDE; I10BI01; tOIOPSIBS; BLOOD
SIBOI; IDIPOSE TISSOB; LIfBS; OU.L
tllDDBI; KIDRETS; PESTICIDES:
CIGaBOIBOSPBlTES; tlOODt 001; ODE:
DIILDBIB; BtPTtCBLCB BPOZIDB;
BIHCBMBOBIBXBBIl UTIGEt BRBOIOGIC
BIBXPBSTtTXOBSl BIOtCCOBOLMIOB:
BltlBOLItBS
BEFBBEICE
Horgada. C.
Bargaet, i.
Pfaffanbargac, c.D.
I960
DaTiaa, J.E.
Barqeet. t.
Freed. T.B.
Bagaa. R.
florgade, C.
Sonneborn, I.B.
Taclavek, C.
1975
U)
VO
-------
•henol, 2,».5-tclchloro-
9«-«5-»
C6-H3-C13-0
« 1«"».5, »P 252 C. T° 1 II Bq at 12 C
ttssnr.
276 B
I4Ipose
JT«9
Blood.
seem
ZIFOSVIE RODTE
mLTTICll
•UMBER
OP CASKS
10
81IGE
lone detected
Hone detected
E
mi
lone detected
wane detected
lie
tat
Coo
CBU
ttr
tci
IIS
Uli!
tcoi
111
59
««c
pit)
CBLt
pin
IDII
PIS
in-
ICO
lleit of detection 0.12 ppi
*atop«les by ndlcil exaelnec, Dade
CBLOlIie OIGUIC CCBPOOIDS;
[IITICBLOFOtfltlOl; BLOOD
ICIPOSB TISSUE: POKICIDES; nsnciDE
IISIDOIS; FlOIIOi; kOTOPSIES;
UlaSOIEHEIT BBTHOOS; DBIIKIIC SITES;
liiits of detection 0,07 ppn
»hlte feiales, Dade Conntf PL,
each ttitb dcioking vatec uea9e
> « it.
CBLOBIIE OiG»«IC COBPOOItDS;
PIIUCSLOBOPBKIOL; BLOOD SEBOB:
IDIPOSE TISSOE: rOIGICIDES;
; ncBioi; IOTOPSIES;
• ItSOBEIEIT BETRODS; DBIHIIG IITEB;
BZ7EBEICE
Borfade, c.
lacqoet. 1.
FfaCCenbergec, C.D.
1940
Borgade, c.
Bacgeet. t.
PCaftenberger, C.D.
1940
O
O
-------
Chmol, 2.*,6-tclcUoro-
88-06-2
C6-B3-C13-0
•I 19T.S. IP 68 C. If 20.5 C. TV 1 •• 19 .t 76.5 C
TISSOB
2770
Idlpoie
2771
Biood.
••CM
BtPOSOlB BOOTB
tllLTTICIL
BBTBOD
OC-BC
_
OC-BC
IOBBBE
OF CISES
10
SB
I1IGE
lone detected
-
Ron* detected
HEM
lone detected
lone detected
CEIIBIL XirOlHKIOl
lllit of detection 0.09 ppi
lotopeie* by iedic«l enilaei. 0»d«
Ccanty. Fl.
CBioniB oieinc COBPOOIDS;
CIRlCBMBOPBBIOli BLOOD SEE OH:
1DIPOSE IXSSOBi FOBOXCIDBS; FBSTICIDE
(ISIDOBS; FICBIDI; IDTOPSIBS;
BEISOIBBEIT BBTBODS: DBIBIIBC IKBR;
•DOLTS
lielt of detection 0.03 ppe
56 nklte «•••!•• Dtde Coanty PI. each
•ith dcinking »t«c nnge pttten > S
ft-
CBIOBIIB OBEtnC COBPOOBDS;
FMTICBIOIOPBEIOI; BIAOD SBIOH:
tOIPOSB SISSOBi FOIOXCIOBS; IESTICIOE
BISIOOBSJ FtOBIDl; IDTOrSIBS;
BHSOIBBBIT BETBOOS; DBIIKIBG IHBB;
1 BOLTS
BBFBIBBCB
Borgtde, c.
Bacqoet. i.
Pfaffenbecaer. C.D.
1980
Bocgtde, c.
Barqaet, t.
PfafCenberqec. C.D.
1980
-------
Pkmol. »-bro«o-2. S-41ckloro-
19«o-«2-7
8t 2*1.49
TISSPI
2772
Idlpon
2'73
Blood,
mr»
.
tiFosoiE lonrt
II1LTTIC1L
HETROO
-
OC-BC
OC-BC
lOflBBR
OF C1SSS
10
_
5B
IklQE
loa« d«t«ct«4
Ion* d«t«ct«d
Ktl
Ion* d>tect«d
ion* d»t«ct»d
GEIEItl TIFOIniTIOl
liilt of d«t«ction O.tS ppi
totapil*< by •«dlc*l •min«i> Did*
ceantr, PI.
CELOITIB o«o»iic conrooiDS;
fI«T»CHLO«OPBll01: BLOOD SBBOH;
«ot pose TissoB; ronciciDis: CCSRCIOB
iisiDoss; nc«iD»: IOTO?SIBS:
IIIISaBBIBIT IBTRODS; OBXIKIIG (HEI;
•COLTS
limit of 4«t«etloa 0.03 pp«
58 (kit* (•••!••. Md* Co«ntj n,
lacb with dclnkiBf »t«c an 9*
(>tt«cn > S jc.
OtOITKB OBO»»IC CCBPOOIOSj
PHTlCBLOIOPBBIOl! BLOOD SBIDI;
tCUOSE TISSOB; POIGICIDES; (BSTtCIOB
I1SIDOBS; PlOlIDt; 10TOPSIES;
BHSBIBUBIT RBTHODS; OBIWIIie »»TE«;
ICOLTS
BirtBEICE
Hocfadt, C.
BsnjtMt, 1.
P(a(f«nb«cgec, C. D.
1980
Hor9*d«» c.
BacqMt, *.
Ptaff^Dlxr^cc, C.D.
1980
-------
PkMOtUnlm. 10-<2-(1-a*thyl-2-plp*rl4yl)*tkyU-2-IB*thyltkio)- (8 CI)
108-rkmothlailD*. 10-(2-(1-Mtkrl-2-Plp*rldlBrl)*tkrlt-2-(B«tkyltklo)- |9 CI)
50-S2-2
C31-I26-I2-S2
N 370.56. IS 72-7B C, IV 230 C at 0.02 •• Bg
nssoB
277«
Blood
2T7S
Brain
277*
Hid n*y
_
2777
lU«r
277»
OClM
BIWSBIB IOOTB
XBg*«tloB
Ing* at Ion
logo «t Ion
IngcatloD
Ing* *t lot
- -
IHLTTICIL
IBTflOD
N(oro**try
oc
FUoco**tcy
BicJd« IB
the ottoc.
BtOOD; Bllll; DI08 1BOSB; DIOGS;
HDIETSt UTIRs SOXCXDI: S8DKITIS;
DIXIBl nlTtBOUTBS
•) 18-rr-old HOIIB, «ecU«Btil
b) 30-fc-old *OMB« mlclda
D«t« gl*«B foe distribution ef
••tabolltu (oildatlon protect*)
dl«d of
•ecldoBtal IB OB* c«««. «alcld* IB
tk* oth*c.
BWODi Bllll; DIOO BBOSB; DSOOS;
IIDIBTS; llfll; SOXCXDBt SBOITITBS;
DIXH; BBTIBOLIIIS
•) 18-yr-eld «OB«B, «ccld*atil
outdo**
b) 30-yc-old «OBBB> nlcla*
0«t» glT*B foe dUtrlbatlOB ct
i*t«bollt** (oilaatloB pcodvcta)
dl*d of «o o<*rdom(
•celd*atBl IB on* us*. (ilcU* IB
tl* oth*c.
11000; BltXIt DIDO 1BOSB; DIOQS;
HDIBTSi IXTII; SOICIDl! SBDITinSi
OIIIB; iBTiBOLXTBS
•) 18-yr-old HOBBB, accldootil
o«*rdoB*
t| 30-rr-old KOBin. saicld*
Cat* gl**B foe dlstcibatloB cf
aatabollt** (oildatlon prodicta)
Catl*BtB dl*d of an ovardoa*,
aecldntal IB on* »•*, «alcid* IB
ti« oth*c.
HOOD! Blalll DBDO 1BDSB; DBOOSJ
iioiBis; inn; SOICIDB: SBD»TIT»SS
OIXIBs HBTIIOLXTBS
a) IS-yc-old «oa«B, accld*atal
Of*cdoi*
b| 30-yc-old COBBB, laleld*
Cat* glf*n (oc dl«tclb«tlon cf
•*tabollt*« (oxldatloB pcodtcti)
Patient* dl«d of an of*cdo**,
accidental In on* ca**, *«lcid* In
tb* oth*r.
BtOOD; Blltli 0100 IBOSB; DlOnS)
ixoiiTS: iiTii; soxcioii SIOITXTES:
OIIIB; ItTIIOLITBS
UFBIBICB
DlnoTo, B.C.
BOBt. 1.0.
SBBSBiB*. X.
cottactalk. L.l.
1978
DiBOfO. B.C.
Bo*t, B.O.
SBBIkiB*, I.
Cottcchalk. I.1.
1978
DlnoTo, B.C.
Boat, 1.0.
Sanahln*, I.
Gottachalk. L.I.
1978
o
U)
DlooTO, B.C.
Boat, 1.0.
Sanakln*, I.
Gottackalk. L.I.
1978
DlBOTO, B.C.
BOBt. 1.0.
S*n*kln*v X.
Gottackalk. I. >.
1978
-------
thenothlaxioe. 2-chloro-10- (3- (dieethrlasino) proprl)- (1 CI)
10R-Phenothlaiine-10-pcopanaaine, 2-chloro-I,«-diaethyl- (1 CI)
50-53-3
Cf-HI'-Cl-IZ-S
111 31*. M. 1* Picrate 172-173 c. 8? 200-JOS c at 0.8 •• a?
277«»
SSttt
•)
04
EXPOSURE ROOTS
mil. mem
NETROD
HDBBS5
OF CISES
11
BIKE
0. 1-25. 0 og/il
DEI*
S.I
Otjth caused by deaf coibinatlons
BacociJs of 1234 deaths in 0. £. and
Canada. In all, dlanpa* or its
••tabolitc «et« pccmnt in the
tiiiuea and. la *o*t caaee, race than
one drag ««a Coaad. ig««: less than
5-greatec than 65 re- Righ (reqaencr
e( suicide, other data available.
Pnlionacy and visceral congestion
lost coason postsortea finding
OB06S; DBOQ 1BOSE; C»«»Di; OH TED
StaTES; OT>H; SED1TITES; BTPKTICS;
fSKROTBOPIC OBOGS; 5LOOD; tl*BI;
IIDBETS; KLCOBOLIC BETIRaGES:
rOREISIC DEDICIITE
BEfEBEICE
fInkle, B.S.
HcClosker, K.L.
Goodlan, L.s.
"
-------
Phosphate
1«26S-a»-2
0«-P
It 9*.«7
TISSUE
2780
Blood,
serue
2781
Blood.
same
2782
Urine
KIPOSOIB BOOM
_
IHI.TTICU
amoD
Colorleetry
Colociaetry
IOBBBB
OF C1SBS
a) 18
bl IB
c) 32
_ -
1
1
BaBGE
•I lot given
b) lot given
e) lot given
•1 0.7-1.3 19/100 ml
b) 3.a-1.8 19/100 al
c) 3,5-3.1 19/100 ml
a) «ot applicable
b) lot applicable
Bill
t| (.2 19/dl
b) 5.0 19/dl
c) «.8 19/di
al 1.0 19/100 il
b) Rot given
c) lot given
•) «1« ag/2» he
b) 300 19/2* hr
GEIBBaL XIFOBBaTIOB
a) 3000 (Bits ot T Italia D2 in
capsales veokly tot ft ao. Leveil at
•tart of study
b) 3000 anitl of (itaaia 02 la
capmlu naklr foi • ao. Lanl at
•od of atodj
c) »itaaln-D-fortlfiad floor for 6
•o. Ufal at «d of study.
laiana In Olasgov, 20 adnlts and «6
childnn froa 1« faalllu.
Some sablact* had bloch»ical
abnoraalltl«a anggastlT* of ctckcta
CE oataoaalacla.
CIICIOB; HBTitS; B100D SBBOB; TRIBII
C; «Stl; OIITBD SIIGDOB: BOTRROIal
DIFICZBICIBSl DIBtS; COIPIBlttTB
H1LOITIOIS; VITIBIIS
.
a) Bator* oral Ca. ?0«. e Tltaaln 0
therapy, on controlled Ca C tO»
intaka 3 day*
bl ?oat 2nd infoaton, m.3g Ca IT
ancinq 15 days
otaarvad proqraaaita daalnrallxatlon
on oral thtrapy tat incc*a*«d bona
danalty on IT.
taanag* faaal* nitb apaatlc
qoadrlplagla. laiobilllad trca
infancy.
IT Ca rallavad ayaptcaa of
anticontalaant-r*lated rickets and
oateoporoala. Oral Ca, vitaain D,
-------
Phosphoric acid, dieihyl aatar
598-02-7
C«-H11-0»-P
gl IS*.10, BP 203.3 C
TTSSOE
2183
Blood
278*
train
2785
line
2786
Oclna
2787
OclM
27R8
Ocln«
EXPOSORR ROOT I
Ingest Ion
TMCIll
tngaatlon
Ingastion
tngeatloa
Ingaitlon
HU.ITTCH |
BETBOD
1
GC/NS
OC/HS
CC/B5
_Wi— «H
OC/IIS
GC
IOBBEB
or cuss
3
1
2
~
2
•1 27
b) 1*
«
URGE
<0. 05-0. 32 ppm
Rot applicable
. _,
<0. 95-1.58 ppi
<0. 05-24. 5 ppi
t) 0.10-2.** ppi
b) 0.0»-0.12 ppi
a) O.G1-0. 1* 19/1
b) 0.09-0.«1 19/1
ntR
•ot gi»«n
0. 15* ppi
•ot gl»«n
lot gi»«o
a) 0.*9 ppa
b) 0.06 ppi
t) 0.07 19/1
b) 0. 17 19/1
GEIIBH. IIFORHITIOR
(•itieldi poisoning.
PISTICIDES; aiTRE: OBGIIOPHOf1>«>TES:
SLOOD: LITfl; BDlII; P8EROLS; CUE
HISTORIES: terra CIBOLIRI
FicticU* polioning.
PISTICIOES; OITIZ; OBO»IOPBO£P1»TES;
ticco; LITEP; ami: PBHROIS; cue
BISTOBIBS; IOSTB CIBOLIIH
(••tielA* pciioning.
PISTICIOES; OBI IE; OBSllOPBOIPBtTES;
BIOOD: Hill; BIIII; P8BIOLS; CUE
BISTOBIES; IORB CIBOLIRl
(•aticila [oiaoning.
PISTICIDES; OBIIE; OB6»«OPHO£Pa»TE3;
BIOCD; LIfEB; BBUR; PBBIOtS; CUE
BISTOBIES; IOBTB CIBOLII1
a) Indi»idoali «spcM4 to Oaianit,
Phorati, and Di-Syiton
fcl On«ipo»«d
(ISTICIDES; OlClBOFBOSPHlTtS;
PBtlOLSj 8ETIBOIITES; OIIIE; DORTR
CIBOLIBl; COBPiBlTIfE (TaLOallORS
a) i ig/daf atari parathion
b| 2 ag/day atari parathion
Total aiccatad par dar ««a 0.16 ag
fee a) and 0.30 19 (or b) .
PISTICIDES; OIGllOtBOSPBlTES; OKIE;
BET1BOIITES; 1011; PBEIOLS
EEfEPIICE
Locas, I. B.
Pradmy, D. E.
nosaaan, R.F.
1978
toca«. E.B.
Brad«ar> D.E.
IIOMian, P.P.
1978
Loras. E. H.
Bradnar. 0.!.
Ifosaian, B.F.
1978
Lom, E.B.
Frad*ar> D.E.
HOMian, B. P.
1978
Shafik. B.T.
Bradvar. D. E.
1976
Borgan, D.P.
•atxlac, B.L.
Slack, E.r.
Lin. L.I.
1977
-------
Fkoaphorlc acid, diaatkyl ••t«c
813-78-5
C2-B7-0»-P
II 126.05, BP 172 C
IISSOl
2789
Bio 04
2790
Ur.r
2791
Orlna
2792
OclM
2793
OtilM
CXPOSORR ROOTB
-
Ingesting
IMraal
Ingvatioa
j .,
iDgaatloa
aRaLRICaL
RETROD
GC/RS
8C/RS
GC/BS
GC
RORBBR
or caSRS
J
1
•» 1
b) 1
a) 27
b| U
«
BARGE
< 0. 05-38 ppa
Rot applicable
•) Rot applicable
b) Rot applicable
*) <0. 005-0. 06 ppa
b| <0. 005-0.0* ppa
.
a) 0.02-0.11 ag/1
b) 0.05-0.23 ag/1
HEIR
Rot jtT*B
60 ppa
a) f ppa
b) «.0« ppa
al 0.017 ppa
b) 0.015 ppa
a) 0.06 ag/1
b) 0.1* a«/l
CIIIR1L IRTORRHXOR
accli«Btal paaticli* polaonlcg.
P1STICIDBS; OURBi ORGUOPROSPRaTRS:
BIOOD; tITBi! BRUR: PRBROLS; CISB
RISTOIIRSt RORTR ClBOLIRl
'•atlclda poiaonlng.
tlSTICIDBS; 01IRE; ORG1ROPI09HK8S;
tlOOO; LtTn; BRalRi PRBR01S; C»SB
RISTORIBS; ROBTR CIROLIR*
•) after ing«attD9 dtetotophca
(1 after Inqaatlng calorprcitoa and
aalatalon
Iccldantal paat,icid*-in9*atlca
patianta.
VISTICIDSS; ORIRB; OROIROPRQSPRaTBSi
ttOQD; IITBB; BRkIR; PBXR01S; CI3B
RISTOBIIS; RORTH CatOLXBk
a) UdlTidaala azpcxd to Daianit,
thoraw, and Di-Sraton
b) OD«ipoa
-------
Vhospkoclc acid, dlietkTl. ester, estec tilth 3-hrdroiv-K-iethrlccotoaaelde, (PI- (8 c II
Phosphoric acid. dlnthfl 1-iethrl-3-(»»thrlasino)-3-oio-1-propen]rl ester, (F,| - (« CI|
C1-H1»-»-05-P
ft* 223.16. If SU-55 C, coiiccclll 2S-30 C
Orlne
EXPOSURE >OOTE
Injection
Derial
>H«1TTIC»L
HETHOD
ItadioBetcy
HOIIB1R
OF OSES
«
BtlSE
a) Hot given
b) Hot given
HEAK
nl 67.7)1
b) la.TX
Ct«fB»L IDFOIIItTIOH
a) TV dose of 1 uci
H Topical adilnlatratlon of 1-S aCi
he. Data in b) corrected foe
il.
BcaLthy volunteers.
FISTICTDES; HEPBICIDES;
OB3A«OPHOSPH»TES: CHLOBIIE OFQUHIC
CCBPODHDS; OBIHE;
BIHCHLOBOCrCtOHiriSE
REFEREHCE
Feldaann, K.J.
nalbach. H.I.
O
00
-------
Phaiphorodlthlole acid. 0,0-dietnyl eater. S-e>ter Kith «-chloro-3- (eercaptoeathyl) -2-benxoxaxoliiioae (8 CI)
Pbosphacodltbioie add, s-f {6-cbloro-2-o»o-3(2B)-ben««yaxolyll«etbyl| 0.0-diethyl ««t»r (9 CI)
2310-17-0
C12-H15-C1-I-O»-P-S2
II 367.80, HE «7.5-«0 C
TISSUE
279S
Orioe
EIPOSOBB ROOIE
alaLYTICtl
SETBOD
ac
IORBBB
OF OSES
2
BtlGB
a) 3U-105 ng/ml
b) 86*-127« ng/il
c) 311-739 ng/il
d| »7>-108« ng/il
•HI
•I 3SS nq/«l
b) 1017 09/1!
c) »56 ng/il
d) 678 ng/«l
GIHBtl IIFOBHITIOH
a) fotker 1,
-------
Phoxpaorodltalolc acid. 0,o-ai««thrl «at«c. S-««t»c ulth 3-(a«rcaptoa*thrll -1,2,3-b»oiotcl*tin-« (JHI -on* (9 CD
Phcipkocodlthlolc acid. o,o-di««thyl S-((»-oio-1, 2. 3-b«niotrl«iln-3 (»B)-yll Mtbrll »«t«c (« CI|
86-10-0
C10-»12-l3-03-»-S2
H 317.3*, If •'3-ia c (ccfitil* ttom ••thinol)
tissne
?iposn«? BOOTS
Injection
mtTTICIL
HZTBOO
IONBES
or c»s?s
UllOt
•) lot qlvvn
b) lot giT«n
•1 69.5*
bl 15. 9*
a| IT doM of 1 «Ci
t| Topical adilnlitcation at 1-5 ucl
9«rcontao,« o( dos*
-------
IkapkoroAttkloic .eld, SMCIP-ckloropk«Byl|tblol«.tkrl.|0,O-«l«tkrl. ««t« <• c"
PkoapaorodUalolc acid. S-UP-ckloropkcnyllthlotMtkrD 0,0-aUthH ««t«r (9 CI|
78C-19-*
C11-B1S-C1-O2-P-S3
II 342.6S. «P 82 C it 0.01 •• 89
TT3SOB
2797
27«8
H»«C
BINSOII IOOTE
lB9«*tloa
TB9a«tiOB
aBUYTXCal
•BT800
tic
00 BC
nc
OC-EC
~ IOBBSI
OP CaSBS
1
1
ItMB
lot appllcabla
.
lot applicable
Rial
1.28 09/9
SBIIlaL XIPOIRaTXOI
Patal polaoalB9
78 jr-old aao
Pilaonacy •<•••, coaovitloB cf
PIStlCIDISS ICTEIj KIDIBTSi
TISECTICIDBS; aOtOPSIBS
fatal polioalBg
78 re-old aan
Polionary adaaa, coBoaatioa cf
abdoalaal tlaaca.
PISTICIDBS; IITE1: nDIRSi
II3ECTICIDE3; tOTOPSIBS
nrBUicE
CoatnllBU, a.
Poalu, L.
(•BtacckoB. p.
Qaaaax. S.
1979
ContMllnl*. a.
Poalos. L.
K«BtaccBoa, P.
Qaaaat, S.
1979
-------
fkuphocodithiolc «eld. S.S'-Mthyl«n«
5S3-12-2
8« )BI.«9. IP -12 to -13 C
TTSSOE
Dcln*
EIPOSORE ROUTE
Injection
Docial
mmicil.
RETROD
Btdiontcr
IOBBES
or CASES
MIGt
gi»«o
9 1* on
tlEU
bl 3.311
•
t
f
h
i
a
8
P
0
c
R
GUfFHt IlroBDATIOI
IT dOM of 1 UC1
t) Topical •dilnlstratlon of 1-5 ad
t
-------
Pboaphorothiolc acid, 0-(2,a-dlckloropheByl) O.O-dlethyl ester
97-17-6
C10-H13-C12-03-P-S
II 315.17. BJ> 16*-169 C at 0.1 as Bg
TISSOB
2800
adipose
2S01
Blood
EIPOSOBB BOOTS
Ingestlon
Ingest ion
IBILKXCIL
BBTBOD
OC-BC
OC-BC
IDBBEB
OF CaSBS
3
11KE
-
a) Bot applicable
b) Bot applicable
c) 67-0.63 ppa
•I Bot applicable
b) 173-2.2 ppb
c) 660-1.7 ppb
(•BIT
Bill
•) 17* ft*
b) 36 ppe
c) Bot applicable
*) 19.0 ppi
b) Bot applicable
c) Bot applicable
PlOE)
GEItllL IIPOBBJLTIOE
•I 76-yr-old Hi* «t autopsy (boat 3
days after an aakaowB das*
b) 52-rc-old feeele 30 dars aft«r
11.2 9 of 75« dlckloteathlon
c) ckang««, «»O»D br blopif, IB
62-rr-old aal« »-5» dayi after 170. 1
9 7Sf dlcfclofutUoa
Pactltloa eoofflclmt data pn«mt*d.
Silcldal lng««tlon«.
B114 OBMt and lat«Bt pha«« (to «8
hi) folloHd by ••me* and
llf«-thnat«Blng cholinccglc crt***
tkat «Bd«l fatally at r«qair«d
prolonged antidotal therapy.
Delayed oaaat of ceeplratory
iBiafflcleacy, hypoteBeloa,
arrkythalae C other chollncrgtc
effects. lleedlB9 froi ci tract,
bypokaleala.
SOtCIDB; 110*101; 1D10PSIBS; BLOOD
SEBOB; 1DIPOSB TISSOB; LITBB; GUL
fllODBBj KIOBBTS) PESTICIDES ;
CFGHOPBOSPBITBS; BLOOD; DDT; DDE:
CIILDBIB; BBRtCBtCB BPOIIOE;
B1»CBLOBOB1B«SB(: LHIOE; ItUBOLOGIC
BIBIPESTITIOBS: BI01CCOB011TIOB;
BEttBOLITES
a) Serea of a 79-yr-old aale at
aetopiy 52. 5 kr after 170. 1 ? of 7SC
dlctlofeBtklOB
t) Chaage In oarni of a 52-yr-old
faaale 1«-7S daya after U.2 9 of 7S«
dlchlofeathiOB
c) Bhole blood level* In 62-yr-old
sale 1-«8 daya after 170.1 g of 7S<
dlchlofeatklCB. seraa le*ela oer*
a tout twice blood lerels.
Suicidal lng«»tlona.
Blld OBMt and latent phase (to «8
krl followed by severe and
life-threatening chollnergic crises
that ended fatally or required
prolonged antidotal therapy.
Delayed onset of respiratory
Insufficiency, hypotension.
acrkytkalas f other cholinergic
effects. Bleeding froa QI tract.
hypokaleala.
SOICIOB; FLOflDt; tUTOPSIES; BLOOD
StBOBs IDIPOSt TISSUE: LITER; CUL
tUDOEB; KIDBETS; PESTICIDES;
OGtBOfBOSPBtTBS; BLOOD; DOT; DDE;
DXF.LDRIE; BtPTICBLCB EPOZIDE:
BIItCBLOBOBEEZEBE; L1TMB; BtHROLOGIC
«l«irBST»TIO«S; BI01CCOBDL1TIOI;
BZTIBOLITES
BBFZIEICE
Daties, J.B.
Barqost, 1.
Freed. T.H.
Baqae. B.
Borgade, c.
Sonaeborn, I.E.
Taclavek. c.
1975
Davles, J.E.
Bargoet, I.
Freed, T.B.
Bagae, F.
Borgade. c.
Sonneborn, I.E.
Vaclavek. c.
19"»5
co
-------
vhosphorotblolc icId, Q-(2,*-dtchlorophenrl> 0,0-di»tnyl ester
97-i7-«
C 10-B13-C12-03-P-S
II 115.17, «P 1«a-1«1 C at 0.1 mm Rg
(COITIROVO)
TISS18
2602
Gall
bladder
2103
Kidaey
EXPOSURE BOOTS
Tngestloa
Ingestlon
intTTicn.
RETROD
•DUBS?
or c»sss
i
2
BaRGE
lot applicable
4) lot applicable
b) lot applicable
RE II
37 pp.
a) 0.83 ppa
b) 1.3 ppa
(IBIT PAGE)
GEIIML IirOtUTIOl
76-yr-old lale at autopsy abcat 3
days after Ingesting an aaknc» to**.
Suicidal lB9e«tlon.
R1U onset ana latent phase (to «8
hcl followed by aefece and
lite-threatening chollnecglc crises
that ended (atallr oc ceqalcid
pcolonged antidotal therapy.
Delayad onset of caaplcatocr
lasgfClclency, S other chollnerglc
ettects. Bypokaleala, abnocul ihlta
call coast 8 blood alncose.
SUICIDE; ItOlIDl; IOTOPSIES; BLOOD
SIIOK; tDIPOSE TXSSOE; LITEI; GILL
tUDDEI; RIDIETS; PISTICIDES;
CfGHOPflOSPIITESi BLOOD! DDT; DDE;
CIILOIII; REPTaCBLOl EfOXIDE;
RIUCTCOIOIEIZElEi LXTfiE; IIOIOLO6IC
CIIIFESTITIOIS; BIOICCOHOlaTIOI;
aiTIBOLITES
a) 79-yr-old aale at aatopa;. 52.5 he
alter 170.1 9 of 75X dlchlofanthlon
tl 76-rc-old aale at autopsy aboat 3
days after Ingestlon of an •nkno»B
don
Silcldal Ingestlonl.
Illd onset and latent phase (to «8
he) folloMd by •••ere and
life-threatening chollnerglc crlMs
that ended fatally or reqalced
prolonged antidotal therapy.
Delayed onset of respiratory
Insufficiency, hypotension,
arrhytheles ( other chollnmolc
effects. Bleeding froa 61 ttact.
hypokalenla.
soiciDE: rioiiDt; lotopsiss; BLOOD
SIIOI: IDIPOSE TISSDE; LITEi; BILL
ClaDDEJU IIDIETS; PBSTTCIDBS;
OIGIIOfMSflaTES; BLOOD; DDT; DDE;
DIELDIII; HCPTlCnOI EPOIIDE;
BIUC8LOIOBEIHIE; HT10E; IWIOLOOIC
BIIIFESTitlOIS; BIOaCCOBOHTlOl;
BETaBOiniS
•EfElEICE
Da»l«s, J.E.
Barqiwt, a.
Freed, T.B.
Haaae, P.
lorgade, c.
Sonnebocn, B.E.
Taclavek, C.
197S
Da?les, J.E.
Banjoet, t.
Treed, ».H.
Bagne, B.
Bocgade, c.
Sonneborn, B.E.
Taclarek, c.
1975
-------
Pk9*pkorotklolc acid. O-(2,«-dlckloroptMnTl) O.O-diatkTl ««t«r
97-17-6
C10-B1J-C12-03-P-S
» 315.IT. I* 164-169 c at 0.1 aa 19
(COITIIOED)
TISSUE
260*
U»«r
BxKsrai BOOTS
XagcatlOB
aBainxcai,
HETBOD
I08BS1
or cuts
... .
i
BalSE
lot applicable
mi
* pp*
.
GEIIUL XIF01BITIOI
76-fc-old ••!• «t 6 otk«r chollMcglc
•tfvcti. Rypokalaila, abnocial nhita
call coant c blood glaco**.
SUICIDE; FLOIXDa; kOTOPSIZS; BtOOD
SHOBt kDIPOSI TISSOS; LITBB; OtLL
(L1DDBI; KIDIBTS; PISTICZOCS;
CMllOFBOSPBITBSi BLOOD; OPT: DOS:
DIELDIII; BBPT1CBLOB EPOJIBB;
BIHCBLOlOBBBlEIl! LtTaOBi IIDBOLOGIC
BIBirESTHIOIS; BIOICCOIHIllTIOl:
BITlBOtlTES
UriBMCE
Da»U«, J.B.
McqMt, 4.
FTMd. T.I.
BaqiM, I.
Botgad*, c.
Sonnaborn, I.E.
Taclavak, c.
1975
Ln
-------
Caocpaorothlolc acid. 0.0-dlethyl eater
2465-65-8
C»-811-03-?-S
HI 170
TISSUE
280 S
Blood
2406
drill*
2007
orlne
2*01
Orln«
EXFOSOBE BOOTE
Ing* It Ion
Derial
TngeatlOD
Ingeitlon
mimcaL
RETROD
-
GC/HS
OC
BOHBIl
3» CISSS
3
1
•1 27
b| 1»
a
BtlGE
<0. 1-0. 16 ppi
lot applicable
_ - _
a) ID - 2.52 ppi
b) lot applicable
a) 0.01-0.07 19/1
b) 0.03-0.11 aq/1
HEtl
lot gl»»n
23. « ppi
a| 0.«6 ppi
b| lot appllcabl*
a) 0.01 19/1
b) 0.07 «a/l
GtltBtl IirOBItTIOl
(•iticid* poiioning.
PISTICIDBSj OBIIE: omUTOPBO £P8*IES;
tlOOD; LITEI: 8B1II; BHEIOIS ; CtSE
BISTOBIES; IOBTR CIIOLIII
P««tlcid« poiioning.
P1STICIOES: OBIIE: OBOHIOPBOSPBilESj
eiOOD; LITEB; BBall; PREIOLS; CiS?
BISTOIIES; IOITR CalOLIM
a) Indiildaala (ipend to Dan nit,
Chocat*. aod Dl-sr«ton
b) OnaxpoMd
PISTICIDBS; OROJIOFHOSP81TES;
FB(»OtS; HETaBOLITfS; OBIIE: WO BIB
CklOLIII; COBPIB1IITE EfllOlTIOIS
t
a) 1 iq/day ethyl (arathioa
t) 2 19/day ethyl pacathion
Total excreted pec day ««s 0.06 eg in
a) and 0.12 tg In M .
PIStlCIDBS; OBOIOPROSPHITES; OBIIE:
RmBOLITES; tOla; PBBIOtS
BEfEBBlrE
locea, E.H.
Btadiay, o.E.
(loaeaan, B.P.
19'8
Loce«, E.H.
Bcad«ay( D.E.
BoMian, p.p.
1978
Shaflk. B.T.
Bcadvay, D.E.
1076
Morgan , D.P.
Retslet, B.L.
slach, E.r.
lin. l. l.
1977
i
-------
thoephorotkiolc acid, 0.0-dlethvl 0-(p-altropheayl) «st«c (6 CX)
Choephorothioic acid, O.O-dlethyl o- (•-•Itrophenyl) ester (9 CI)
56-38-2
C10-BH-I-OS-P-S
II 291.27, IP 6 C. BP 375 C et 760 » Rg, 157-162 C at 0.6 •• 19
TISSOB
2809
Blood
2810
Blood,
plasaa
2811
orine
2812
Orlne
EXPOSOU BOOtB
Dereal
Tngestlon
Injection
Dereal
Ingeitlon
tlaLTTICal
SETHOD
GC/RS
GC
ladloietry
GC-IC
IOIB8I
or cists
. . ,--
1
1
6
a
MISB
lot applicable
lot applicable
a) lot given
b) lot given
a) lot given
b) lot given
c) lot given
0.03* ppe
2.6 a 9/1
a) *S. 8f
ta| 9.7*
a) 29*
b) 29*
c) 10*
GBKUl XIFOIHaTIOl
Peiticide poisoning.
PESTICIDES; OIIIE; OSGHOPBOSPBHES:
BLOOD: tlVtli BB1II; PBBIOLS; CaSB
aisroBiBS: IOITI cuoLiia
level 16 br after ingestlon cf
anknonn anoint of Granoxone
£( yc old suicide vlctle.
subject becaae anarlc, hypotmeive
Death dee to cardiac failure ao hr
after ingestion of herbicide.
PZSTICIDES: USE HISTORIES:
BCISOIEBEIT SET HODS
a) IV doee of 1 uci
b) Topical adalnistration of 1-5 aci
Percentage of dose excreted in 120
br. Data in b) corrected for
lacoaplete recovery based on data in
• 1 •
laalthy volunteer*.
PISTICTOIS; HERBICIDES;
OBGAIOPROSPHITES; CBLOIIIB OKHCIC
CCHPODIDS; OBIIE;
amCRlOBOCTCtOaflllE
a) Paraaltrochenol
b) Oiethylphosphate (aetabolite)
c) Diethylthlophoaphate (aetabollte)
1 recovery in 2a hr after a Jg or »g
dose.
PISTICIDIS; CBGllOCROSPBaTES; OBIRE;
BIT1BOLITES; 1011; PHRIOLS
BEPBBEICE
Lores, E.B.
Bradmy, D.E.
Roaeaan, B.r.
1978
van Dijk, a.
Ebberink, B.
de Groot, c.
Raea, B.a.i.
Doaxe, J.S.C.
van Herat , i.i.p.
1977
reldeann, E.J.
Balbach, B.I.
197a
Rorgan, D.P.
Retzler. B.L.
Slach, B.r.
tin, L.L.
1917
-------
Phoaphorothloic »cld. O.O-dlcthfl 0-(3,$.«-tclchloco-2-prcldrl) ««t«r (6 CI)
Pboapkorothlolc «cld. 0,O-dl«thyl 0-(3,S,6-tclchloco-2-prcldiiirl| »»t«r (9 CI)
2«21-M-2
C9-R11-C13-1-O3-P-S
BB MO.ST. It »1-«2 C
TISSO!
2813
Blood
2«1«
BC«ltt
2115
llT.C
ETFOSORE BOOTS
Iig»«tion
lB9««tlOD
Tn9«*tlon
»I11TTICIL
HET10D
ac/^s
-
OC/IIS
BC/HS
VOIBEB
or cuts
1
1
1
_
IUWGB
lot «pplic«bl«
fot cppllcibl*
lot tppllctbl*
«»H
0.210 pp.
O.f ppl
0.08 pp*
GIIIML I«rO»B»TTO»
(••tlcid* pcisoBlnq.
fISTtCIDSS; OBIIS; 0«C1IOPRO£PH»TZS;
SIOOD; LITEti BR1II; PBBIOIS; C»SB
BISTOBIBS: 10 KB CUOLIli
Mitlcld* poicoolnq.
PtSTICTDES; OITIE; OBO»IOPHO£PIHTES ;
BIOOD; LtTHi SIIII; PBElOtS; CUE
Bisiotivsi tore a ciBotim
(••ticldtt polaoniog.
PESTICIDES; OtllE; OBOHOPROJPHITES;
BIOOD; LITEIi BI1II; PIEtOLSi CiSE
HISTOIIES; IfliTH CIBOLH1
BEFEBKIICE
Lorai, *.B.
Fcail»r, D.E.
ROSVBAD, B. P.
19'8
Loco. :.B.
Br«d««y, 0. !.
Hos*i«n/ I. r.
1978
Loc*>, E. fl.
Bcadny, 0. E.
Roa«ian. B.P.
1978
00
-------
Fkoipkocotklolc tell. O.O-4i«tkyl, 0-(Z-iiopropyl-e-Mthyl-a-nyrialainyl ««t«r (8 CI1
Ikoapkorotklolc acid. O.O-«l«tkjl o-(6-««thyl-J-(1-««tbyl«thyi)-»-pyri«iainyl) cater (9 CI)
333-»1-S
C12-EZ1-B2-03-P-S
N 30«.3i, n tecoip abo»« 120 C, ft 83-8» C at 0.002 » Hg, TP «.1I10(B-») at 20 C, 1.1110(8-3) at «0 C
TIS30I
2S1(
Blood
IIKSOU 10DIB
kltLTTICU
•BTIOD
IOBBBI
or CUBS
1
itiBB
lot applicabl*
mi
a ppa
GBIZM1 XBTOIB1TIOB
Poiionlig fatality
iESTICIDBS; IBSHZC; ILMMXBS
CIIBOB IIOlQinC CflBMDBDS; HOOD;
LifBt; KiDiBis: Bin: OIXBB; LOBES:
BIlBTi SVUBB; BBtIBi BLOOD SBBOB;
TtllBSSEE; C1SB BISTO1IBS
imiEICB
B>y*a. I.J., Jr.
Taafkn. B.R.
1977
VO
-------
Paospaocotaloie acid, 0,0-dliethyl eater
1112-31-5
C2-17-03-0-S
HI 230
1ISS11
2«1->
llool
2118
Grins
211°
oclne
2«20
DC ID*
•IPOSORB COOTS
Xngeatlon
Derial
Infection
IBaLTTICat
genoo
OC/BS
uc/ss
PUHBM
or casss
3
1
•1 16
bl 3
C) 2
a) 27
bl It
Btass
<0. 1-0. 13 ppi
lot applicable
a) <0.00»-9.-?9 ppa
b) <0.00«-0.2» ppi
c) <0,00<-2.68 ppa
a) 0.02-0.22 ppi
bl 0.02-0. 11 ppi
lltll
lot gif»n
7.«6 ppi
a) 0.f-S.*8 ppi
b) 0.02-0.06 ppi
c) 0.01-0.70 ppi
l«og> of acani.
•1 0.09 ppi
b) 0.07 ppi
GtlEltL IiroRUkTICI
P«BticL4e poiioninq.
PfSTICIOIS; OBtlE; OBGlHOPHO£PHiTES:
BtCCD; tlTtt; BBilH; PtlEHOLS; CtSt
BISIOHES; HOBTH CIBOLIM
Pcatlcla* poisoning.
PISTICTDES; OBI HI; OBGKOPBOEPHJTES;
SIOOD; LITBB; BB1II; PinOlS; CISt
BISTOBIES; ICBTB CIBOLIfk
a) Ir«» tklnmca
ti Poc«ifln
c) Trrlgatoo
l*f«la tak«n daily toe S Aafi.
B«eo*«rr of utliatid 4o«« 29. S-6«». .
adult ial« fl«lca>-iMcican fata
laborcca (aq« 21-63 rcl working in
California paach orchard treated «itb
Gnthlon.
Cecceaie in blood chollnestetaH
actl«itr tat no clinical algn* of
crganophoiphate toiiclty.
PtSTICIDBS; ORGalOfBOS9BiTZS ;
CCCOPlTIOUll BaZaBCS; OBTIE
a| indlTldeala espcMd to Daaaait,
thocate, and Dl-Syaton
b) Dnelpoaea
CISTICIDES; OBOaBOIROSPRaTBS;
FBEBOLS; BITJBOtlTIS; OUBE; BOBTH
CIBOLIU; CCRPaBtTIVI BTaLOaTIOBS
BIFEB'HCE
Locei, !.n.
Fcadxy, D. ;.
Roseaan, fi.P.
1978
Lores, E. II.
Ecadway, D. E.
Roseian, B. T.
1978
Rraus, J.P.
Pichacds, D.R.
forhani, 1.0.
Hall, P.
Kilqoce. «.«.
•inter lin. V.
1977
Shaflk, n.T.
Bcadvay, D.E.
1976
to
O
-------
TaoipBOCOtkloLc acid. 0.0-dla»tkrl 0-(p-Bltropken Jl) aster (6 CXI
Mocphorothlolc acid, O.o-dlawtkfl O-
-------
phcspaocas
1723-U-0
f
IH 30.47376. IIP «».1 C. BP 280 C, »P 10 •• Hg at 127 c
TTSSHB
2321
2*2«
Blood.
2D25
Hldner
2426
Urer
SIPOSOBB SOOT!
iiALTTicAi.
RETROD
«s
es
IOHBEB
OP CASES
3«
a| «
bl 2
«) 132
b) 73
c) 87
t) 91
b| «•
c) 76
IAIHE
2.5 ig/dl - lorial
.
a) 3.0-3.3 19/41
b) S.a-8.0 ig/dl
a) lot gl»en
b) lot given
c) lot given
al lot given
b) lot given
cl lot given
1141
lot given
a) 3.1 ig/dl
b| 6.5 >9/41
a) 7500 ppi
b) 7520 tfm
c) 7580 pp>
a) 9*00 ppi
b) 10,800 ppi
cl 9,180 ppi
QFIIItl IirOIIIUTIOl
locial cang* i» 2.8->.5 ig/dl.
Idalt ipllcptlc patients atttndlng
(Kirologr o«tpatl«at clinics of
Toronto G«n«cil and Toronto «»t«cn
agi »5 rt (tang* 26-72 fi) .
HypophoxphatfiU In * of 39 fttivnti.
CltCIOa; HITIBOLISB; CREIOTRtRlPT;
fBCSPBOBOS; inTHES; 5IIBB»L«;
aiOBOXTCROLICILCIPHOLS; BIOCD SEBOfl:
CIITR1L HtHfOOS STSTEH DISEASES:
CUHDl
al Control!
tr) Patlcati »ltk hrpopacatkrroldii!
CILCIOl; PHOSPIOIOS; 1ET11S;
1-ITlBOLITES; BLOOD SEIOR; OIIIE;
IIDtOITCIOLICtLCIPtlOLS; fITJSH D;
OIITED KIIGOOH; >ITkDIIS
a) lo renal disease
t| tcute cenal failures
c) Chronic cenal failure!
lalaes are dry vt basis.
Igtopstes at OClk Hospital.
TB1CB ELEIEITS; lETlLS; 101OCSIES;
CILirOMIl; KIDIETS; LITES; 5PLEZI;
CISElSBS; IfPnTIISIOl; SODIDR;
POTMSIOl; CllCIOIl; (IIOSPHOIOS:
BiGIESIOa; ClOBIOi; ZIIC; COIPtl;
tI»D; TIOI; BklSIIISZ: 1L08IIOI1;
SIIICOI; TITMIOB: COBatT: BICIEL;
•CLTBDBIOR: Til: CBBOSTOH; SltORIOR:
BIBIOS: LITBI01: SIITBB; TIIIDIOD;
eevoi
•) lo cenal disease
E) tcvte renal fallarei
c) Chronic renal failures
Dry «t basis.
latopsles at DCL> Hospital.
11 ICE BlBBErtS; BBTatS; lOTOfSIES;
CalXrOllIt; KIDIETS: H'EI; JPLBEI;
CTSEASIS: RTPEITEISIOI; SODIOR;
POTaSSION; CtlCIOB; PHOSPBOBOS;
BIGIESIOH; C1DHIDR: II1C; COJPB1;
iI»D; IIOI; RklOllESB; ItBHIIDR;
SILICOl; TITllIOBl COB1LT: ITCKBl;
BOITBDEIOR; Til: CBiORIOH; SnOITXOH;
Blllda; LITBIOR; SIUEt; T»IIOIOB;
BCIOI
iEFEREMCE
PTlTpchuk. S-
Creopoalos, 0. G.
vilson, D.B.
Harrison, J.E.
ncielll, t.C.
Ogilfl., B.
startrldgc, w.c.
narcay, T.a.
1978
Rawer. E. B.
Davles, n.
Backhoase. J.
Rill, l.r.
Taflor, C.n.
1976
Indraprasit, s.
Alexander, G.T.
Goniek, B.C.
I97a
Indcaprasit, s.
lleiander. G.T.
Goniek, R.C.
197»
N)
(IBIT PAGE)
-------
Pkcapkorna
T723-U-0
p
Itl 30.97376. IP M.I C. BP 280 C. »P 10 aa Bg at 127 c
(COITIIOED)
IZSSOB
2827
Spleen
282S
Orine
2829
aciM
-
BIPOSOtB BOOTB
titiniciL
iBTBOD
^
BS
US
BOBBBB
or ctsBS
...
•1 91
b) «0
cl 76
•1 *
b) 3
12
mac
•) lot glTen
b) lot gl*«
c) lot given
•) 761-1006 ig/day
b) «63-663 ig/day
a) lot given
b) lot given
Oil
al 10,500 ppa
b) 12,700 ppa
e) 11.300 pp«
a) 888 ag/day
b) 591 ag/dar
al 0.6*3 » or - 0.058
g/daf
b| 0.6*6 » or - 0.039
1/4ay
SIIIUI, XROBMTIOI
a) lo c«>«l
bl lcat« canal ft liana
e) Ckronlc tanal tallans
Dry *t ba«ia.
>ltopai«« at OCLl loapital.
TI1CB UBIEITS; BBTU.S; lOlOfSIBS;
CILIFOIIII; (IDIETS: tlTBBj SPLEBI;
DISBISISI BTPntBISIOl; SOOIOI;
[OTISSIDI; CttCIOBt PHOSPBOBOS;
itaiBsioR) ctoBram nic; COIPBI;
HID: no«: HioiiisB; iLOiiioB:
snicoi; TiTinoi; COBU.T: IKKBL;
eOLIBOBIOR; Ttl; CBBOHIOR; snORIOB
91IIOB; LXTBZOR: SILfBI; V1IIDXOR:
IC10I
a) Coatcola. 32-36 «k pngnant,
Itaatlcal 4Ut»
t) 32-36 iik pngnaot. 1 g/daj aitca
ealelna
7 pclaapacai. agad 16-19 yc
CILCIOR; RaSIISIORi PIOSPROIOS:
BITtLS; OBIII; PEKQIllCt; DIRS;
»OSTB»LHj COHPllttlTB BTkLOITIOIS
a) Lou flbac diet
b| Righ Clbac dUt
lea 37 to 58 yr old.
(lean dally talance »0.361 g en
lo»-Clb«c diet and »0.292 g on
hlgh-flbac diet.
• COLTS; OBIII; RBTtU; TB4CB
ElBHBITS; DIRS; FIBCBS
IBFBBEICB
Indcapcaalt, s.
lleiander, G.T.
Conlck. B.C.
197*
Daggln. G.o.
lynekaa. I.e.
Dale. I.E.
E*ana. B.*.
Tiller. O.J.
197*
Klaay, J.L.
Jacob. B.».
Prttkec. l.S.
1979
-------
Chthalaxlne. 1-hydraxlno- (1 CI)
1 (2fl)-Phthal«iinona, hydrazone (
86-Sa-n
ce-ne-i«
IH 180.IS. KF 172-173 C
tissue
2130
Blood,
plans
2X31
Urine
SIPOSOU! HOOTS
Ingestlon
Injection
DTE
HSHLTTICH
IIFTHOD
HPLC
SC
HPLC
BOBBER
or CASES
1
•
MICE
a) 0.23-0.05 ul
b) 1.5-0.30 uR
c) 2.60-0. 21 ul
3.10-8.20 X of doss
mi
a) Hot applicable
b) lot applicable
c) lot applicable
5. » 3 t of dose
a) Rydralazlne, 20 and SO sin
r) nydralazlue plus setabolltes. 25
and 200 sin. 1.5 «1 at 10 sia
c) Hydcalaxln* pyrurlc acid
bydraxone, 2! and 375 sin
Dose, S tuoles/kg, oral, to fast
acetylator. Stellar data for IT
Subject drug-free for 2 vk before
study, and slthout cardiovascular
disease. Pasted before and after
dose.
DBUCS; BLOOD PLaSll; k DOLTS;
BIPERT'WSIOI; COBPlRaTITB
ETILUtTIOIS; flETABOLISl; lETtBOLITES;
OBIIE
Reasured hydralaxloe pycuvlc acid
hydraxone after 1.5 usol«s/kg IT
26-39 rr old sales, drug-free for 2
ek before study, and without
cardiovascular disease. Fasted
before and after dose.
CBO-.S; BLOOD PLaSII; » DOITS;
HTEERTEISIOli COBPIRATITE
ETlLOaTIOHS; BETaBOLTSI; BETIBOLITES;
OKIE
Shepherd, l.*
Ludden, T.n.
Haegele, K.D.
Talseth, T.
»c»ay, J. L.
1910
Shepherd, t.n
Ludden, T.H.
Raegele, K.D.
Talseth, T.
relay. J.L.
1970
-------
(ktkalic acid, bi*(2-«thTla*>ayl) **t«c (8 ci)
1.2-B»ni«n«dicarbo*TUc acid. bU(2-.tkylh«yl| ««t«r (9 CI)
117-81-7
CJ*-B38-0«
Bl 390.5*
TISSUE
2832
UlpOM
2833
Blood
BxtosoBB IOOTB
anLTTICU
RRROD
_
GC-BC
OC-BC
IOBBBB
or ctsis
3
•) 9
b) 13
UTCE
-
a) 0.90-1.37 d9/» mt nt
b) 0.29-1. IS «g/q «t «t
c) 0.35-1.29 «g/9 ««t «t
a) 0-0.02 ft*
b) 0.05-0.20 ppi
a) 1.15
b) 0.6*
e) 0.65
a) 0.01
b) 0.13
asai
1.15 ag/g n«t «t
0.6* 19/9 «»t it
0.65 09/9 wt *t
GEII11L IiroiUTXOI
a) saipl* 1
t) Sa«pl« 2
e| 3aapl« 3
lln* dlff«c«nt «elT«nt« t««t>4.
Ti«an« coll«et«6 during »atof»l»B on
aceldaat vlctla*.
CBtOBIIB ORGIIIC COHPOOIDS; IDIIOSB
TISSOE; COBPIUTITI BTUOtTIOSs
•OTOrSIES; PtSTtCXDBS; DDT; tSTHHtlC
ICTDS; POLTCBLORII1TED BIPHSITtS
a) EMfoc* a«ali
t| nftar Mali
"
Healthy Japanu*
PRRaLIC aCIDS; BLOOD: FOODS! OBGHIC
CBIOIIIB C01EODIDS: JlPll!
tOLlCBLOtlllTID BIPBBltLS
BBFERBICE
B««, J.
Caaptwll, D.s.
1976
Toalta. I.
lakaiaca, I.
laql. T.
1977
IS)
-------
ththaUe acid, dibgtrl «at«c (B CI)
1,2-B*nz«n«dlcacboirllc acid, dibutyl e«t»r
6(-7«-2
C15-H22-00
UK 2-I9.3«, BP 3(0 C
CI)
Tissue
213«
(load
EtPOSUBt ROUTS
HILTTICM
KETHOD
OC-BC
..
»nnB!P
or CISES
al 4
b) 13
BAKG»
a) 0-0.06 ppa
b) 0.03-0.18 ppa
_ .
1E»»
a) 0.02 ppa
b) 0. 10 pp«
_
GCIEBtL IHfORIIIlTIOH
a) Oefocfl aaals
b) Hftec aeals
Healthy Japanue
FHTHkLIC HCIDS; BLOOD; FOODS; ORGHIC
CELOBIKB COBfOOHDS: JUPMI;
tClICHLOBIIOTID BIPHEITLS
BEFtBEIlCI
Toalta, I.
Kakaaura, T.
ragi, t.
1977
-------
[iperazlne, 1-(«-a«ino-6,7-diiethoST-2-g.iilnsxollsfl)-«-(2-fiirojl)- {8 ci)
Plperazlne, 1-<«-asino-6.7-dlsethory-2-9;olnazolin»l)-«-<2-faraiiylc«rbonTl| - (9 CI)
19216-56-9
C19-I21-IS-0*
•I 362.«2. BP 276-280 C
TISSUE
283S
Blood,
plasaa
2B36
Blood,
•hole
BIPOS01E BOOTS
Ingestlon
Ingest ion
lEalTTICiL
RETROD
Flaorosetry
BPLC-Plaaroaetry
BOIBEB
OP CISES
2«
al 9
b) 9
BaBGE
a) 6.2-76.1 ng/al
b) 15.S-82.3 ng/al
c) 27.1-85.6 ng/il
a) 3.5-22.5 ng/al
b) 3.3-11.5 ng/sl
HEIR
a) 35.9 ng/al
b) 39.1 ng/al
cl 58.2 ng/sl
a) lot applicable
b) lot applicable
GBBEBtL IIPOBBITIOR
a) Man peaks, 0.5-21 hr after one
5-ag capsule, peak tlae, 2.2 he
b| Man peaks, 0.5-21 hr after 5 ag
aa 2- and 1-ig capsules. Peak tiae.
2.0 hr
c) Bean peaks, 0.5-24 hr after 5 ag
as solution. Peak tlae, 0.7 hr
Baalthy Bale volunteers.
DBDGS; DROG TBER1PY; BLOOD PUSH*;
COBP»BaTI»B EVaLOanORS; HIPIRTEISIOB
a) Controls. Bange of Beans 0.5 hr
and 123 Bin after 5 ag. Final value.
1.7 ng/sl at 6 hr
8.0 ng/al at 8 hr
IstiBated froa graph.
line healthy sale controls, ages
36-70 yr old, on their usual
•edicatlon and seals but in tod.
DRUGS; HE»RT DISEASES; CALIPCRIlIk;
•CULTS; COKPtBlTIfE ETtLOtTICHS;
CIOOD
BEPEBEBCE
Bobbs, D.C.
Tooaey. T.B.
falser. R.F.
1978
Jaillon, P.
Publn, P.
Tee. T.-G.
Farrlson, D.
Blaschke, T.
1979
-------
PipetULne. 1-(l-pl>«nTlcyclotexyl)-
71-10-1
C17-125-R
in :n).14, *F «6 c, a° 135-137 r «t
TISSOB
283'
Slool
Hood,
plasea
2131
Brala
Kidney
2M1
ll»ee
«IPOSOB» snote
Ingestlon
Inhalation
T 09* it ion
Tngestlon
Inhalation
Tngestlon
lag* st ion
Inhalation
lltLYTICIL
KtTBOD
OC
sc
OC
OC
GC
BOBBER
or cisss
n
•
6
1
q
R«GS
0.3-12.0 a 9/1
0.09-0.22 ng/il
0.1-32.0 sg/kg
Rot applicable
0.9-80.0 ag/kg
i:ki
2.39 ag/1
0. 11 ag/al
7.27 ag/kg
0. 1 ag/kg
. , „. ,
20.1 ag/kg
ItltBUL IirORBHTIO«
Fhencrclldlna relatad deaths,
aubjecta aged 15-27 re, fcoa Orange
County, CA.
Polaonacr edeaa, aoderate to aacked
congeation oC langa and livei, and
anoxic petechial heaocrhages in lungs
at one case.
IBOIS; BLOOD; B8AIR; KIDIZTSi IITEB;
lORGS; OBIi;: CASE RISTOBIES: DBOG
icosE; OLiPcmn
Ofecdose patieata
IK TC old (eaale, 26 ji old lale, 20
re old aale.
Scan patlenta coaatoae, agitated,
disoriented.
CIOCS; BLOOD PL1SB.I: 01 1 HE;
ettsoBEgeiT IETHOOS; cist ainoRiES:
8LOOD SEIOII
Phencyclldlne related deaths.
avbjecta, aged 15-27 yc, Ccoa Orange
Coanty, Ca.
falaonary edeaa, aodecate to aacked
congestion of langa and livac, and
anoxic petechial heaorrhagea in lungs
of one caae.
OBues: BLOOD: BR»I«; KIDRETS; LITER;
LORQS; DRIRR: CiSE HISTORIES; DRUG
HOSE; ciLiroBiii
Phencyclidine related death, subject
aged 19 yc, fcoa Otanqe Coanty, Ci.
Fulaonacy edeaa, aodecate to aacked
congeation of langa and liter, and
anoxic petechial heaocchages in longs
of one caae.
DRUGS; BLOOD; BRaIR; RIDRETS: LITER;
tOIGS; OEIRI; CaSB HISTORIES; DRDG
lEUSE; CtLIFORRIl
Phencyclldiaa related deatha,
subjects aged 15-27 yc, fcoa Orange
County CJU
Culaoaacy edeaa, aodecate to aacked
congeation of lungs and li*ec, and
anoxic petechial heaocchages In lungs
of one ease.
DBOGS; BLOOD: BRaIR; KIDRETS; LITER;
LORGS; ORIRB; CkSE HISTORIES; DBOG
IBOSE; ClLIfORRIa
BlrCREUCE
Cratey, B.R.
Beed, D.
Bagle, J.I.
1979
nacshaan, J.n.
Baasay, n. P.
Sellers, E.H.
1976
Ccavey, F.a.
Reed , D.
Fagle, J.L.
1979
ccavey, R.R.
Feed, 0.
Fagle. J.L.
1979
cra»ay, R.H.
Reed, D.
Ragle, J.L.
1979
(REIT ?»GE)
ro
oo
-------
Fiparldlna, 1-<1-ph*nylcyclol>azyl) -
77-10-1
C17-825-1
BI 2*3.38. IP «6 C, B? 135-137 C at 1 aa R9
(COETIEOBD)
TXSSOB
2B*2
Lug
2B»3
arm*
28*1
Dcln.
EXMSOBE SOOTt
..
Ing*«tlon
Inhalation
lageatioB
Ingaatloa
Inhalation
allLTTICU
BIT8OD
oc
oc
oc
-
BOBBEI
OP CtSBS
3
2
s
MME
0.«-7.6 agAg
-
2.3-6.5 IJ/2I hr
0.«-«8.6 a 9/1
RB1I
2.97 ag/ltg
a. a Bg/2« he
21.66 a 9/1
OBinaL IirotBaTXOB
Pbancfclldla* c«lat«d t«atha,
aobjacta «9«d 15-27 yc, froa ocanga
ccanty, C«.
lalaonacy •dm. aodarat* to aackad
ccngaitlon cf Iun9« and ll»ar, and
anozic patachlal h«aoccha9«a IB laagm
of oa* caa«.
DBOGSt BLOOD; BB1II; KIDBBTS: LITBB;
lOIOS; OBIBI; CtSE BISTOBIESl D100
aEDSB: CIIIFOBII1
Initial 2« kr Brlnary «xcr«tloB in
o»«nJo»« patlaota Kith Initial plaaaa
conc»ntcatlon« of 0.11 and 0.09
09/al.
SOB* patlanta coaatoaa. agitated,
dlaoclantad.
DBOSS; BLOOD PLaSHa: OBIBI:
IlaSOBBlBIT BCTBOOS; C»SB BXSTOUES;
BICOD SBBOB
Pbancyclldlna ralatad daaths.
•objects agad 15-27 yr. froa orange
County, Cl.
Polaonary adaaa, aodacat* to aackad
ccngaatlon of langa and lir«t, and
anozic patachlal baaorchagaa IB longs
of OB* caa*.
DBDQS: BLOOD; BBall; KtDBETS; LITER;
IDBGS: DBIBI; CaSB RISTOIIES; DBOO
ICOSB; CaLIfOBBIl
BBFEBEBCS
CraTay, R.a.
Bead, D.
Bagla, J. L.
1979
aarahaan, J.t.
Baaaay, B.P.
Sallara, B.H.
19i«
Craray, p. a.
Baad, D.
Bagla, j. i.
1979
ID
-------
tiparidUlua, 1, l'-(l«lph«. 11b>ta-dihydroxr-'>alc>na-aiidroBtan-21>*ta,16bata-ylaiia)bU(1-aathrl.-, dlbcoalda, diacrttta (» CI)
Plparldlnina. 1,1'-((2h«t«.3«lpha.5«lph»,16b»t«, Hbata) -3.17-bla («c«t]rloir) «n4ro«l«o«-2,16-ac«an
•ictlon.
OIO<:S; DIOG TBtlaPT; PEINSILUlIa;
BIISDHESBIT IETBODS: STBBOIOS;
»P10«IO!1 COIfOOiDS; BLOOD S5FOB;
oeeiLicii co ID; BEUTR Hniacs;
CONPtltTtTB EULOtlTOIS
BErEBEICE |
1
Iboal.Uh, E.
last, D.C.
GMhl, T.J.
1970
U)
o
-------
felybroalaatad blphanyla (lo poolings U CBMLIIB).
TISSOB
28*6
Blood,
««r«a
2«« 8
Blood.
aaraa
28a9
Blood.
aaraa
28 SO
111k. fat
BIPOSaiE IOOTI
IngaatloB
IBILTTICIL
RETROD
OC
- -
OC
OC
OC
BORBEB
OF CISBS
31
a) 163
b) 938
It
31
a) S3
b| «2
IIBOE
0.1-89.0 ppa
a) Bondetactabla-0.3 ppb
b) Boadatactabla-0.3 ppb
a) 1-1530 ppb
b) 1-1363 ppb
< 1-1 82 ppb
a) Bot d«tactad-1.2 ppa
b) Bot d«tact«d-O.S ppa
RBIR
Bot glna
a) Bot glTan
b) Bot glna
al 30 ppb
b) 23 ppb
lot gifm
a) Bot glnn
b) Bot glnn
GBIBIIL IEPOBRHIOR
Rlchlgan daicy fara realdanta froa
contaalaated aru in 1976. Idipoaa
tlema lefala 300 tlaaa highac than
aaraa lavala, and in equilibria! with
ttaa.
tCIPOSE TISSOB; BLOOD SEBOR; FOOD
CCRTaRmtXOR; RICRI01B;
POLTBBOHIB1TRD BIPBBBIL5: BISCOBSIB
a) Biacaaaia dairy fara reaidanta.
PBBa nondatactable la 127. at llalt
of detection (<0.2 ppb| in It. and
>0.3 ppb in e
b) Hlchlgan dairy fara realdtnta.
PBBa nondetactabla In 7, at Unit of
detection (<0.2 ppbl in 29, and >0.3
ppb la 902.
Blaconain raaldaata froa
aoacoataalnatad ar«a, Hlchigan
raaldaata froa araa coataalaated by
teed-Blsing incldant.
IDIPOSE TISSOE; BLOOD SBBOB; FOOD
COBTIRlEaTXOR; HICRXOIR;
PCITBROHIEITBD BXPREBTLS; IISCOISII
a| Borkara In plant prodaciag PBBa.
1976 lerela
b) Saaa vorkara, 1977 latela
IDIPOSE TISSOEl BLOOD 58808; FOOD
CCEtaBIEITIOB; RICHIOaB;
POLTBIOBIIiTlD BIPBEETLS; IISCOISII
Blchigan dairy tara realdenti troa
eontaaiaatad araa in 1976. Srrna
lalias la •qalllbriaa with adlpoaa
tlaaaa talaaa at 300 to 1. fat to
laraa.
ICIPOSE TISSOB; BLOOD SEBOR; FOOD
CCITMXIITICE; RICHIOABi
PCITBIOIIBITID BIPBBBTLS; IISCOISII
a| Lo«ar paaiaaala-51/53 had
datactabl* lavala
b) oppar panlnaala-18/«2 had
datactabla lafala
Bialdanta of 2 dlatinct ar«a> of
Blchlgaa. «9«a 1* to >S yr, nho 9«t»
birth daring lagaat 1976.
tIPREITL COD POO IDS: BBOBIRE; niLK;
BICBICll
IEFEBBBCE
Bolff. R.S.
Indaraon, R.I.
Boaanaan, I.D.
Salikoff. I.J.
1979
Bolff. R.S.
Indacaon, 8.1.
Boaanaan. K.D.
Salikoff. I.J.
1979
Bolff. H.S.
Indaraon. H.I.
Poaanaan. K.D.
Sallkotf, I.J.
1979
Holff. R.S.
Aadarson, R.I.
Boaaaaan, K.D.
Salikoff, I.J.
1979
Brilliant. L.9.
labarg. G.T.
lablatar. J.
Raaphray, R.
•ilcos. K.
Eyatar. J.
Blooaar. I.I.
Prlca. R.
-------
PclYchloclnated dlbensofarans (to postings in CRERLIRE).
TTSSD?
2051
Adipose
28S2
RldBeT
21S3
ll*ec
28S«
ll*ec
2855
Lang
2856
Spleen
EIPOSORE tODTI
Ingestion
KULTTTCU
1ETROD
CC
GC/HS
ac
tx
GC/BS
GC
GC/«S
CC
GC/BS
ac
cr
oc/ns
GC
CC
GC/BS
QC
ROBBER
or CASES
a) 3
bl 2
2
2
al 3
bl 2
1
2
BARGE
a) 0.006-0.013 ppi
b) Rot detectable
0.0002-0.0005 ppe (vhole
tissue)
a) »ot applicable
b) 0.1-0.3 ng/g
c) 1.2-«.S ng/g
d) 0.3-1.6 ng/g
e) Rot applicable
fl 1.6-6.* ng/g
...
•) 0.003-0.025 pps (vhole
tissue)
lot applicable
<0. 00005-0. 0001 ppi
NEAR
a) 0.009 ppi (vhole
tlssie)
t>) Rot detectable
__
0.000* ppi (vhole
tlssae)
al < 0.02 ng/g
b) 0.2 ng/g
c) 2.8 ng/g
d| 1.0 ng/g
e) < 0.05 ng/g
fl «.0 ng/g
*) 0.013 ppi (vhole
tlss«e)
Trace (0.00005-0.0001
PPD
Rot given
GEBIRIL IRFOB1ATIOI
a) Tasho patients
b) controls
Materials fcoe aetopsles.
BIPBERTL COBPOORDS: CRLOBIRS OB1HIITC
CCB90010S; BICE; OILSEED CBOfS; POOD
CCRTA1IRATIOR; DISUSES; A01CPSIES;
MOACCOB01ATIOR; PCLTCHLOIIIATED
B1PRERTLS; ADIPOSE TISSOB; KIDRETS;
LOR3S; SPLEEI; LIVER; JAPAR
Aatopsr utecial (roi Tasho patients.
1IPHERTL C01EOOWDS; CRL08IRE OHGARIC
CCHPOORDS; BICE; OILSEED CROPS; POOD
CORTABIRATIOR; DISEASES: AOTCPSIES;
eiOACCOSOLATIOR; PCLTCHLORIRITID
RIPBRRTLS; ACIPOSR TISSOE; KIDRETS:
LORGS; SPLEER: LIVEI; JAPAI
a) TrlchlorodibenxcfaraQ
t) TetcachlorodltenoCacen
c| Pentachlocodlbenzofaran
d) Retachlorodlbenzofaran
e) Heptachlocodlbenxofaran
() Total polrchlorlnated
dlbenzofarani
Ceceased Tasho patients, I"1 and 25
tCLTCBLOIIIATID BIPBBRTLS;
CRLORIRATED BTDIOCARBOBS; LIIE8;
JAPAI; POOD COITARIRATIOR: DISEASES;
IICE; OILSIED CROPS
a) Tasho patients
t) Controls
BIPHEiri COBPOtlRDS: CRLOIIIE 0 SOAR 1C
CCBPOORDS; RICE; OILSEED CROPS; POOD
CORTARIRATIOR; DISEASES; AOTCPSIES;
EIOACCOBOLATIOR; POLTCRLOBIRATED
BIFBEITLS; ADIPOSE TISSOE: SID RETS;
LORGS; SPLEER; LIVES: JAPAI
latopiy sat«r Lai froi Tasho [itlent.
EIPRERTL COBPOORDS: CHLOBIIE ORGAIIC
CCBPOORDS; BICE: OILSEED CBOtS; POOD
CCRABIIATIOR: DISEASRS; AOTCPSIBS:
CIOACCH10LATICR; PCLTCBLORIIATEO
BIPBERTLS; ADIPOSE TISSOE; HID RETS;
LORGS: SPL8BR; LIVER; JAPAR
latopiy eater la 1 froa lasho (atlents.
BIPBERTL COBPOOIDS; CSLORIRE ORGAIIC
CCBPOORDS; 1KB; OTLSEED CROPS: POOD
CCITABIIATIOR; DISEASES: AOTCPSIES:
EIOACCOROIATIOR; POLTCBLOBIIATID
EIPHEITLS; AUPOSB TISSUE: KIDIBTS;
LOIGS: SPLECR; LIVER; JAPAI
RErEBEHCB "
Ragafaia, J.
Kasuda, T.
Kacatsane, II.
1
lagaraia, j.
Rasada. T.
Karatsane, 1.
1977
Pippe, C.
Poser, H.P.
Kacoki, R.
Raiada, T.
1979
Ragayaia, J.
Basoda, T.
19TT
Ragayaia, J.
Basada, T.
Karatsnnef B.
1977
Ragaraia, j.
Rasada, T.
Karat sane, B.
1977
U)
K)
-------
Potasslas
7MO-09-T
I
It! 39.096, IP 6X2 C, BP 76£.5 C. IV 100 II 19 at 590 C
nssai
2857
141 DOSS
2658
tort*
2859
Blood,
plan*
2160
ttood.
secui
2861
BXPOSOBE IOOIB
Injection
IBalTTIHL
BETHOD
I- ray spectres
.
X-ray spectres
us
BOHBEB
OF CISBS
•
9
•) 16
b) »
187
12 of 1*
llfCB
lot given
lot given
a) 3.7-S.3 ssol/1
b) 2.6-a.9 asol/1
a) lot 9 Iran
b) lot 9l»«n
3.H-5.2 aBg/1
(IBTT
HB1B
352 pps dry ft
J»9» ppa dry «t
a) a. 02 aaol/1
b) 3.«6 aaol/1
a) 20. a 19/100 si
b) 20. • 19/100 il
1.65 sBg/1
PICE)
OEBZRaL lEFOBBaTIOl
Idnosinal fat. 2 aasples pec case.
2 analyse* on «ach saipl*.
197« antopaiaa of 10 Pl» Indians, a
Eapa9O Indian, and a craak Indian.
POTISSIOB; CltCIOB; HOB; COfPBB;
I IIC; BOBIDIOB; BICIELi tt»D; HETaLS;
TMCE E1EBBBTS; 1I»U: SPLEBI; tOBTt:
KIOIBtS; 1DIPOSE TISSOB; PaBCBBlS;
BtaSOlBMEBI BETROOS; aDTOPSItS
2 aaapl«B pec case. 2 analyses on
each saeple.
197* autopsies of 10 Pisa Indians, a
Papago Indian, and a Cceek Indian.
voTissigg: ciicioa; IBOB; COHEB;
IIBC; BOBIDIOB; EICIEt: LBaD: BBTaLS;
I BICE E1BBEBTS: LITEB; SPLBBB; iOBTi;
(IDBETS; JOIFOSB TISSOB; PMCBBaS:
BIISOBEREBT BBTRODS; 1BTOPSIIS
a) locaokaleale patients, tcaated
aith di9oxln< facoseslde, and
(otasslas
b) HypokaLesic patients, treated Kith
dlgoiln, facoseside.
hydcoehlocothlaxlde, and potassinn.
(atlents receiving dally tceataent In
Copaoha9«n, Censark hospital.
Bocnokalenic patients (age 2^-64 yc)
«lth chronic congestive heart Cailuce
dae to stenosis and sttcal
insufficiency. Bypokalesic (atlents
•1th congestive heact failure.
Boderate hypokaleaia reduced the
active tubslar secretion of dlgoxln.
thus Increasing its half-lif«.
HOGS; POTASSIOB; BIOOD PUSH;
ADULTS; RtiBT DISBISBS; DEBHUX
a) Ben
t) Rosen
Criteria for Ion levels < 13.1 eg/ 100
• 1.
Boral ntahns, 58 sen, 129 no ten, aean
age 69 yr.
DTBTS; TBICI ILEBEBTS; CROLESTEBOLS;
BIOOO SBBOB; ZIBC; COPPBB; PCTaSSIDB;
SOOIOB; IICDISina; CaLCIOB; IBOB;
fiTtiin i: fiTiims
Catlents on aalntenance dosea (roa
0.125-0. 25 eg/day
11 aales, 3 Ceaalea aged 51 -89 rr
(chadnled to undergo arologlc
surgical procedures
ClU-iS; 1BTILS; POTISSTOB; BLCOD
SEBnn; SPIItl FIOTD; DBOC TRIBtPT
BETBIEICE
Rangelson, B.f.
Bill, B.B.
BielsoB, C.K.
Eatough, D.J.
chrlstensen, J.J.
Ixatt. B.B.
Bichards, D.o.
1979
Bangelson. K.r.
Bill, R.I.
Bielson, K.K.
Eatough, D.J.
Chrlsteasea, J.J.
Ixatt. H.8.
Bichards, D.O.
1979
,
Stelness, E.
1978
Fisher. S.
Bendrlcks, D.G.
Rahoney, a. V.
1978
Gayes, J.R.
Greenblatt. D.J.
Lloyd, B. I.
Bacaatz, J.s.
Saith, T. K.
1978
U)
U)
-------
PCtaSSlnS
7MO-09-7
8
»t« 39.098. HP 63.2 C. i? 76!.S C. It 100 » 89 at 590 C
(COITUUtD)
2162
Blood.
seraa
2863
Body
296*
Kit
2K6S
Kidney
2866
Kidney
* IPO Sim BOOT!
M1LTTICAL
•P.THOD
Indlosetry
X-ray spectron
IDBBBR
OP C1SSS
12
a) 137
b) 7«
C) 90
RMGE
lot applicable
«) 1756- 3775 Holes
b| 1733-3312 neoles
1195-2370 pp>
•) tot giYen
b) lot given
•I lot glTen
b| lot given
c) lot given
6.3 »«q/l
• I 2739 nsoles
bl 2553 moles
2155 pps
a) 9228 pp. dry it
b) 99->2 pp. dry *t
4) 7230 ppi
b) 7120 pp.
c) 6750 pp.
GEltttL
Co adiliilao 5-6 he «{t*r 14
• 1-yc-old «eun, inq*at«d 11 >q,
Oil»c«lty Boipit.l. San Diego, c«.
Dims; DBOS tBOSE; BLOOD SMDH;
CIlirOBIIti IIIEBkl HETISOLISI;
fCTlSSIOl
•) Pc*op*catli* total-body K
t) ?o«top«catl** total-body >
Fcaopacatlf* totcli vlthin nccial
canq*.
Patients oadacfoinf heart Tali*
c«pl.c«i«Dt, ulthoot cardiac cackeiia
CtCocv opecatioD.
PCTUSHJH; lITtLS; 9IIEML
HR»OLISH; IBTIBOLISH; OIITID
KIIGOOR; BOOT
Scalp hair
Dcooc* fcoi 2 rillagu of Vaika
lodlana ID the 1atzonal Territories
at Tenexeela.
BUI; TEltZOEU; BET 1LS; TRaCE
ILBBEITS; SODIOI; ILOHIIOI: SILICOI;
CBLOItlE; POTtSSIOB] SCalDIOC;
lITtltOI; MlaDIOH: CBSOHIOI: COLO;
HalGalSSE; IBOI; C011LT; IICIBL;
CCPPEt; ZIIC; aRSElIC; SELSIIOB;
eioiiis: soBioioB; snoiTioH; SILTER:
alTTHOITi TODIIE: CESIOB; BinOS;
CIRIOB; StBMIOB: BBRCORT
a) Bedalla
tt coctei
2 aaiplei pec case. 2 analysis on
eack sasple.
197* aatopsles of 10 Pisa Indians, a
Papa^o Indian, and a Creek Indian.
fCTlSSIOB; C1LCI01; HOI; COFPN;
SIIC; ROBIDTOB; IICKE1; LE1D; BBTILS;
llaCE ELEBEITS: LITER; SPIRI; aOIT4;
IIDIET5; 1DIPOSE TISSOE; ?»CllaS:
HCISOIBHEIT BETBODS: aVTOFSIIS
a) lo renal disease
bj acute renal fallens
c) Cktonic cenal fallens
lalon ate dry it basis.
Igtoplle* at OCl» Rospltal.
TRICE BLBRBITSJ BMaU; aOTOKISS;
CIIIPOIII1; KIDIZTSi LITER; 9LRI;
pCTisstoa; CILCIOR; PHOSPBOBCS-
BIGIBSIOB: C4DBIOBI II1C; COIPEI;
HID; IIOB: BalGIBESB; aLDRIIDI;
SILICOI: TIT1IIOB: COBUT; IICKBL;.
BCIT80UOB; Til: CBtOHIOB; SUOtTIOH;
BIBIOB: LITBIOR: SILVER; THIDITO;
tOIOI
larren. S.E.
Faneatll. D.D.
1979
(ale^y. R.K.
Good*, l.v.
Bentall, B.4.
1978
Perkons, 1. K.
Telandla, J.I.
Dienes, 9.
197-"
OJ
Hanqelson, I.P.
Bill, n.».
llelson, U.K.
Eatoagk, D.J.
Cbcistenssn, J.J.
Iiatt, l.B.
Richard*, D.o.
1979
Indraprasit, 5.
llaiaader, O.T.
Gonick, B.C.
197«
-------
Potaaalaa
7«*0-09-7
I
at! 39.098. HP 63.2 C. tt 765. S C. TP 100 •• 19 at 590 C
(COITIIOID)
TISSOE
2867
L1»«C
2861
Ll»ar
2869
Panccaaa
2870
SplMB
2871
Splaan
EXPOSOIS BOOTH
1IUTTICU
RETROD
X-e»r apactcoa
is
X-e«y apaetroa
r-cay apactcoa
IS
IUHBEI
or cuss
10
•1 42
b) »«
O 7«
.
«
8
•1 02
hi MO
D| *V
c| 7S
11IOE
lot glnn
•) lot glvrn
b) lot glran
e) lot gl»an
lot gi*an
lot glvan
•) lot glTan
b) lot Qlvan
c) lot gl*an
(•BIT
HBtl
1003 ppi dcy «t
a) 7»60 pp.
b) 78(0 ppa
c) 7350 ppi
8735 pp« dcr >t
12558 ppi dry *t
a) 11.600 ppi
hi 1A nflA nn*
Dj iiitUuu ppa
c) 10,000 ppa
P»3t)
oiiniL inoiBtTioi
2 a>apl«a takvn p*c c«««. 2 analra**
COB oa each «aapl«.
1S7a a«topal«> of 10 Piaa InUau. a
Papago IDdlan, and a Cc**k led Ian.
POTaSSTOH; CkLCIOH; IlOli COIPEI;
xiic; tOBieiDR; iicni; IBID; aBTtis;
TlaCS IIIHEITS; livn; SPL1BI; lOITa;
IIDIBTSI IOIPOSB TISSOBi PalCIBaS:
BIISOIMIIT BtTRODS; aOTOPSIIS
a) lo cvnal dis«a>«
t) Icat* t«nal fallaraa
c) Chronic canal failara*
Valaaa ac* dry «t baaia.
lotopaiaa at DC 11 Roapital.
IKCI ItlBERSi BETJLS; IDIOtSIES;
CILIPORIXi] (IDIETSl LITB1; SPLEEI;
CISIaSBSt RTPEITEISIOI; SODIIHi
potassioR: ciicioi; piospioins;
aiciEsioN; ciDHioR; ii ic; conn;
HID: THOU; RalBlIISR; alORIIDR;
snicoi; TiTHioa; COBILT: IKKBL;
BOLTBDIIOR; Til; CBIOHIORi S1BORIOH:
B1IIOB; LItBIOH; SILTEI; TlllDIOB;
ecioi
2 aaaplaa pac cam. 2 aaalrxa oa
•ach aaapla.
I97a autopalaa of 10 Piaa Indlani. a
Papago Indian, and a CrMk Indian.
POTtSSIDR; CalCIOH; IIOI; COiPEI;
IIIC; aOBIOIOB; IICIEL; IE10; BETltS;
TlaCE ELSREITS; LHI8; SPLBBI; aOBTI;
IID'ETS: IOICOSE TlSSni; PtHCRElS:
BHSOI81SIT RETRODS; IOTOPSIIS
2 aaaplaa pac caaa. 2 analyaaa on
aaca aaapla.
197« autopalaa of 10 Plaa Indian*, a
Fapago Indian, and a Cca«k ltd Ian.
POTtSSTORi CILCIOB; IIOlj COtPEI;
IIIC; lOBIDIOHi IICIEL; IBID; IBTtLS;
TlaCB ELBBBBTS; LITEEi SPLEEI; »OBTl;
motets; xoipost TISSUE; paicitEas;
BItSOtBilBIT BRRODS) aOTOPSIIS
a) lo canal diaaaaa
c) Chconlc canal dl>«as«a
a) diffacant fcoa t| and cl , P<0.01
faluaa aca dcr «t bails.
latopataa at OGLt Hospital.
TB1CE (LRBEIISi BETtLS; tOTOtSIBS;
CtLiromtt; KIDIETSi ItTEB; SPI.EEI;
OISBkSES; RIPERTEISIOI; SODIOB;
ICTISSIOB; CltCIOl; P8OSPROICS;
SIGKBSI01; CIDBIV1; lt«C; COfP'B;
H«D; IIOI; HllStltSE; UOBTHH;
SILTCOI; TII1IIDB; COBILT; IICKEL;
BOITBDEBOH; Til; CBBORIDH; S1BOITIOR;
aiBioa; LiTBion: SIL«ES; tmoian:
tCBOl
BBFBBBICE
Rangalaon. i.r.
BUI. H.I.
llalaon, I.I.
Batoagk. D.J.
Caciatanaan. J.J.
Ixatt. E.g.
Klcharda, D.o.
1979
Indcapcaalt. s.
llaiandac, o.T.
eoniek. R.C.
I97a
Raogalaon. i.F.
Rill. R.I.
Blalaon, I.I.
Eatoagh, D.J.
Chclatacaan, J.J.
izatt, I.R.
Blchacda, D.O.
1979
Rangalaon. I.P.
Rill. H.I.
llalaon, U.K.
Eatoagb. D.J.
Chclatanaan. J.J.
Ixatt. B.H.
Blckacda, D.o.
1979
Indcapcaalt, s.
Haxandac. S.T.
Gonlck, B.C.
197»
-------
Potasslua
lt» 31.091, HP 63.2 C, HP
C. TP 100 •> Hq at 590 C
(COITIEOED)
TISSUE
21">2
Teeth
2"3
Heine
EIPOSOBI! BOOT!
tlaLTTICll
RETROD
Radloietry
n
RORBEB
OF CaSES
291 teeth
•1 <
»l 1
«l«GE
a) lot gl»«n
b) lot gl»«n
c) Hot gif«n
•) 2. 27-1. 20 q/2« he
b) 1. "»e-3. 15 9/2* he
a)
b|
el
al
l>)
0.01«* of ash
0.021* of ash
0.020% of ash
3.02 9/2* he
2.16 9/2* he
GEIIMl IIPOIIUTIQI
a) Dociduona
II 22-28 ye
c) >3« re
Poolid a»;l«. af«ta9< 7 t«rth pee
•aipl*. cthtc data availabl*.
Teeth feoi (Qcpl* living in IOMC
Silesia In southveitecn Poland.
SIBOITTOH; CILCTOfl; CSSIOH;
FOT»SSIIIIIi BUDIOISCTOPES; (IE11LS;
POltBD
a) Healthy iale, 5 aetecilnatlou
Ofec * 10
c) Healthy feeale. 2 detecilcatlooc
10 eo apart
additional data available.
IIT1LS; TB1C! ELE11ITS; IBSBnC;
BBOSIIE; CUCI0R; C8LOBIBE; COBILI;
CRIOHIOH; CESIUB; COPPER; HEfCORT;
ICOI1!; POTISSIQR: lUOlRBSEi SODIDH;
BORIOIDS; SEIRIIOR: ZI»C; ORIREi
BItSOREIEBT BBTRODS
Glovlak, B. J.
Pacvna, J.
PalcSTDSkl. 9.J.
Cocnella. R
Speecke, A.
Hostet J.
19-»5
U)
-------
53-03-2
C21-B26-05
II 35B.M, If 235 C
TISSOR
281*
BlOOd,
plUlt
EIPOSORE BOOTH
IMLTTIC1L
RBTIOD
_ ..
ROBBER
OP (USES
6
E1RGB
20-70 og/dl
REAR
Rot given
GEIEIII XRPORI1TXOE
Rtig* of p*ik<, MtiMMd dona of
5-50 •<].
HMlthr ••!•«. >g«d 27 » ot - 3 If.
DIOOS; I001TS; BLOOD PLISRti
HRtBOLRISi 11 « TCIK: STEROIDS;
R0110IB5: DROS TBER1PT;
CCITICOSTRROXDS; GLDCOCORtXCCIDS
RIVE
Rom, J.Q.
Juko, I.J.
RlckclMB.
1979
RERCE
J.I.
LO
-------
Pt«
fc«9na-1.o-.lUn«-3.20-«> Crai S-50 ig
oe p«t*«.
Htaltkr •>!•»/ <9«d 27 » or - 3 rr.
C1U1S; tOOlTS; BLOOD ?LISIU;
StTHBOtlTES; «5W TCBIC; STCBOIDS;
BORgOIES; DIOG THEBtPT:
CCtTICOSTIIOIBS; GLOCOCORTICCIOS
BJrEStHC!
Pose, J.Q.
Jasko. «.J.
1<"T»
CO
oo
-------
Pregaa-1.a-dlane-3.20-dione, 11beta.17,21-trlkydcoiy-6alpka-Bethyl-, 21-acetate (8 CD
fregva-1,«-dj.ene-3.20-dlone. 21-(acetyloiyl-11.17-aikydroxy-6-aetkyl-. (6alpka, 11bet a) - (9 CI)
53-36-1
C2I-B32-06
II 41C.52. if 205-208 C
TT330I
2876
Hood.
pl»u
2877
Orlno
.
BTMson toon
Inaction
lectal
tectal
aiunxcti.
KBTBOD
me
aadloaetry
IUBBBI
or cuts
12
12
MICE
•) lot given
b) lot given
c) lot given
*. 52- 5 6.8* of AoM
mi
al 153 ng/al
b) 178 ng/al
c| 22 ng/al
3«.3* of 4o«*
(ndl»)
61IBH1 IIIOIRMIOI
•I lean p«>k «ft«r 10 •! oC 3.60
•g/»l ot*l
puk «t 3 kc
t| Man p«ak aft«t 10 il of «
oral •*tkrlpi*inl«oloa« aeatat*.
Bon p»k at 3 hr
c) Man p«ak after «0 tg 3B-lab«ll«d
a«tkTlpc«4nl«oloD« aeatat* »
c«t«tio> aaaaa. Bcaa peak • kc.
locaal inbjict*, ages 22-4* jr, oa no
abdication oc alcokol foe 7 day*
tafoc* atady, faitad bvfoc* and after
tan*.
DI06S; OtOCOCOITICOIDS: BLOOC
OBIIIi FBCtS; COBPilaTITB ITILOtTIOIS
S-dar caa«lati»e eiccetloaa after
«0-ag dos* of 3H-labelled drag a>
retention eneea. Percent inversely
related to tlae of 1st bo«el aonaent
after dose.
loraal >«bj«cta, ages 22-»» yr, on no
aedlcatlon or alcokol tor 7 day*
before atady, faatid before and after
dcae.
OIOOS; SLOCOCOBTICOIDS; BIOOE PLkSRt;
OIIIB; PBCISl COBPtBtTITB ETILOlTIOIS
BBFB1BICE
Oarg, D.c.
tagner, J.O.
sakaar. E.
leldler. 0.3.
albert. U.S.
1979
Garg, D.c.
lagner, J.G.
Sakaar. B.
leldler. O.J.
tlbert, K.s.
197«
LO
-------
Pre9na-1,».*-triene-3r20-dlone. 6-chloro-11beta,n.21-li:lnfdro>:y- (' CI)
fre9na-1.«,6-triene-3,20-o'looe. f-chloro-11. l^l-trlbydroif-. (Hbeta)- (•) CI)
1H ?**2.91
TTSSOt
2170
Blood,
plasea
EXPOSES SCOTS
Ingestlon
Injection
mLTTICIL
RETROD
GC/RS
ROBBES
OP CaSSS
.1 •
b) »
c| 1
dl •
e) 2
fl 2
BlIGE
a) 2.75-»1.3 H9/sl
b) 1.45-»7.0 ng/al
c) 2. 13-14. 1 n7/«l
d) 3.2»-««.2 ng/sl
e) 1.7-30.S ng/il
f) 1.8-50.S ng/sl
1B»»
a) Hot giien
b) Hot given
e) klot given
d) Dot given
el lot glr«n
f| lot 9iven
GEIEBtL InrOBHiTIOW
a) 2.50-sg dose in capsule ilth
starch and lactose
t( 2. 50-S9 dose in capsule «ith
atarcbc lactose and ea9nesi«i
stearate
c) 2.50-sg dose in tablet Kith
starch* lactcse* proTidone and
aagnsslas stearate
d| 2. SO eg orally in 103 el of 151
ethanol-10< citric acid buffer
c) 2.0-B9 oral dose in norial
sallne-xtbaool (9: 1)
() 2.0-sg If dose in norsal
sallne-etbanol (9: 11
f«ak levels after oral doses-occurred
in 30-5--.3 tin.
•orsal adelts (sean a9e 31.1 yr, sean
w.ig.t 78.2 kg) .
CPU1S; COBTICOSTE1CIDS;
GIOCOCOITICOIDS; BIOOD ?LaSRI;
>RI-I«PL1R!IITOBT tGEITS; tllLGESICS
1EFEBEKC!
nroszcxal'. e.J.
Punkal, B.
Strand. t.J.
Toslinson, 3.T.
rratls. K.
Segre, t.
1978
-------
FroUctln (Til)
9002-62-*
BIICT COBMSXTIOI OinOII OB OIDETBBBIIED
ai Iboat 23.000
IISSOB
2879
Blood,
plasea
2880
Blood,
plassa
BIFOSOBE ROOTS
Xngestlon
tMtnxClL
BBTHOD
lit
.«
BOBBBB
or cists
13
RtlOE
a) Bot given
b| lot given
c) lot given
d) lot given
ej lot given
10-1*0 ng/nl
BBll
a) 13.2 • or - 1.3
ng/sl
b) «8.« » or - 11.?
ag/sl
c) 112.9 t or - 26.6
ng/sl
dl 33.7 » or - 7.2
ng/nl
a) *9.2 * or - 3.7
ng/al
lot applicable
GEIIlll TIFORBaTIOl
a) Base levels after sashoat. Levels
in tesales slightly higher (1*.* vs
11.8 ng/al)
b) Dales, eean peak 2-2* hr after 00
ag oral bataperaxlne
c) Fesales, lean peak 2-2* hi after
*0 ag oral bataperatina
dt Rales, 2 i »0 eg/day batapirazine
1-2 vk
a) Feaales, 2 i 00 eg/day
tataperasine 1-2 «k
Frolactin levels net correlated with
classa or IBC batapenslae.
chronic schlsophrenics
DROOS; DROG THIilPT; BLOOD PUSIt;
BlITBROCTTISi RORROBBS; BBBTCDS
S1STEB DISEtSZS; SEX; tDOLTS
Beans before to • "k after BOO eg/day
aalpirlde. Baiisal effect after 1
ik. Ifter « sk. plassa and CSf
levels correlated, r-0.80, p<0.025.
Barked indivldaal variation.
Psychotic »oaen nith thought
disorders, delasions, and aaditory
hallacinatlons. lo organic train
disorder, soaatlc disease, alcohollse
or drag abase, tges 33 to 6? yr.
Sida Effects incladed: slid
extrepyraeldal effects, tension In
breasts, sosnolence. Redaction lo 2
paychopathological rating pacasetera
•Ithin 10 daya.
OB01S; Dane TBBItPI: IRITOOS StSTEB
DISB1SBS; SIEDBI; BLOOD PUSH:
SFIIlL PLOXD; ROBHOIESi lEOBCLOGIC
RllirESTftTIOIS; » DOITS
REFB1EICE
snith. R.c.
Taesinga. C.».
Crayton. J.I.
Dekirsenjlan, B.
Davis, J.I.
1979
BJerkenstedt, I.
Barnryd, c.
Sedval, G.
1979
-------
Prollne. l-hydroiy-. L- (« CI|
t-Prolina, *-hydro»y-, tt*n«- (•» CI)
51-35-*
It 131.13, IP alpha too 27* C, bata tot* 231-2«1 C
-______--
TtSSIB
L'laq
SIPOSORE ROOTI
Coloclntcy
IOHBE9
or CASES
•1 19
h| IS
•) 17.">-2'».'' «9/
-------
Propanaaide. 2-anl»o-l-(2.6-dlMthylpheayl)-
»1708-72-9
C11-116-12-0
B» 192.26
TISSBB
2882
Blood
2883
Blood.
plan*
284*
Blood.
plassa
2885
Ocin«
EIPOSOIE BOOTB
Injection
Inaction
Ingest ton
Tngestlon
-
UaLYTICaL
BRROD
/
cc
Colorieetry
OTIC
GC
OC-EC
RPLC
IUBBEB
OF CaSSS
,
•1 6
b» S
0 6
dl 5
•1 «
b) 6
1
6
BIKE
•t lot given
b) lot given
c) lot given
d) lot given
a) 13-3.6 anoles/1
b) 2.8-0.5 e.solos/1
«) 2.45-0.075 ag/sl
b) 5. (0-0.16 09/1!
«) 28-55* of dally dose
b) 16-31* of dally da*e
c) 15-30* of dally to**
SB»I
•I 11.7 ug/al
b) 18.7 ug/el
c) ». 6 ag/el
i) 7.77 ag/sl
•I lot applicable
b) lot applicable
al lot applicable
b) lot applicable
a) aj. at of dally
don
bt 23.3* of dally
dole
c) 23* of dally dose
GEIIBaL IlFOIBaTIOl
a) after infusion at 0.50 ag/kg/ein
b) tftec Infusion at 0.75 ng/kg/sin
c) 15 Bin after Infulon at C. 50
•g/kg/sln
d| IS eln a (tec end of Infasion at
0.75 ag/kg/aln. Peaks occurred at
end of InfMioa.
Sobjecta, 32-63 yc old, had mdargone
diagnostic cardiac catketeriutlon.
DIOBS; BtOOE; BEUT DISEISBS; tOOtVSi
CCIPlBHIfB mLOlTIOIS
a) Patients. 0. S and 2« hr a (tec 33
etoles/kg IT oier IS a in
b| Healthy sabjecti, 0 and 2 « be
after 6 molei/kg IT over 20 eln
Oat* also gifen foe eingle aid
repeated oral dovei.
Bealthy >alea. average age 23 yr.
(atients «ltb acute ayocardlal
infarction, agee 51-75 yr.
Cecreaae In fentrlcolar
tichyarrhytbalai la aoat patients.
CI01S; DBDC IBEIaPI; BEalT DISCiSBS:
ICOLTS; BIOOD •LISBi; SKDEI
a) 30 aln-SO hr after «00-ag dose
b| 30 aln-60 hr after 800-ng dose
12-hr fast preceded each dosa.
latlaated fron grach.
60 yc old, 67 kg patient.
OI01S; BLOOD PLtSIII; HBaSOIEEEIT
BITHODS
a| Btcreted unchanged
t) 1«lea»ed ty acid hydrolysis
c| leleased by glnearonldase
(patients only)
2>-hr canalatiTe recovery of
tocainlde after naltlple or tingle
doses of 300-3200 eg/May. Typical
urine levels of free tocainlde vere
30C-600 ag/nl.
treatnent with tocainlde HC1, and a
•ale control.
0*.OGS; UTItBBBTTRlIC tGBVTS;
gmBOlISI; OIIIE
BirEIERCE
Schvarts. fl.
COTlno, B.
Dace. B.
lareng. 1.
Piore, J.
Barkells. n.
Rixnl, s.
seith, B.
1979
craffnec, c.
conradson, T-B.
BofTendahl, s.
Hyden, L.
1980
Beffln, P.J.
Barapat, s. 8.
Barrison, D.c.
1977
Elvln. 4.7.
Ceenaghan, J.B.
tyrnes. E.H.
Tenthorey, P.I.
Cclaster. P.D.
Taknan. B.H.
talk*, D.
Hanlon. r.T.
Baer. D.T.
lolshln. E.I.
HaVVBaM* M H
nvjviTr n* De
Ron f eld, B. t.
19RO
-p-
*-
u>
-------
Eaaadoephedclne, (•)- (1 CI)
Banzeneiethanol, alpha-(1-(••thylaeino)ethyl)-, (S-(B*,8*|)- (9 CI)
90-92-«
II 16S.23. IF 119 C
TrSstJE
9 load
tlier
29«9
Orlne
EIFOSOBE ROOTE
Ingeatlon
UtLTTIClI.
BETBOD
gptr
JOH1ER
OF CtSES
Btice
lot applicable
lot applicable
116-10* ag
110 «in«,
d-bcoiphenicailn«t d-isocphedrlne,
FEopo«rph«n«, alcohol.
5S rc old Kbit* f«•«!«.
IICOIOLS; IIBCOTICS: DBtlCS; ELOOD;
ami!: «i»ii; LITKB; UTiom«ssiv>
»CK«TS; COIItCTTCOT; OBOO HOSE; CASE
BISTOitBS
Fatal oi«tdo»« fcoi tranjlcf[roain»,
d-bcoipb«altailiM, d-i«oeph*dclae,
ftopovyph*D«t alcohol.
5? yc old uhlte Ceial*.
UCOROtS: ItlCOTICS; DROSS; ILOOD;
Omit; BI»I«; LITER; HITIDEPtESSITE
tGEITS; COIIKTXCDT: HOC 49CSE; C»SE
BISTOBIBS
1«-hr ncln««. Pang* corceapcad* to
y[ia« pH canoe f.31-S.aS( aftec 9 19
cblocphenlcaiiae caleate aad 120 19
pieadoaphedclne ncl ultk oc tithont
«B«cl. othec data arallable.
Healthy, nonobeae aabjecta on DO
othec dcaga, enxrie-indacing agents,
•onoailne oxidaae inhibitor* foe 1
•onth, no caffeine oc alcohol during
itndr.
CIOOS; 1EISOBEBEIT HBTIODS; CBIIE;
H1TMOLITES; BETtBOlISB
Panlt. S.C.
Shaakan, E.
Gross, ;.B.
1977
Baaelt. P.r.
Shaakan, E.
Cross. E.n.
1977
Lai, C.B.
Stoll, B.C.
look, z.B.
Tacobl, t.
1979
-------
PyrUlM, 2-(p-bro«o-alpha-(2-(dia»thyl«aioo)«thyl)b«a«rl)- (6 CI)
2-PyEiaig*pEOP*MilM. 9aiB«-(t-broao|>h«nyl)-I.l-4i««layl- (9 CD
86-22-6
C16-B19-BE-I2
If 319.3. BP H7-1S2 C at 0.! •• Bg
TISSUE
2889
Biooa
2890
line
EXFOSOIB BOOTS
, -
IIUCTICIL
METHOD
OC
OC
IOHBB1
OF C1S8S
1
1
UKB
lot applicable
lot applicable
Hill
0.2 ag/al
».5 ag/9
9BIIUL IirOHHIOl
-
latal orwdOM CEOI tc»Bylcyfro«io«,
4-bcoapbanlraalB*. l-l«o«ph«dElM,
pcopoxTpk«n«, alcohol.
5; yr olfl «klt« f«a>l«.
IICOBOLS; IlKOTICSs D50GS; tlOOO;
OIIIB: Blklll LITBRI alTIDBPRSSITB
IOBRS; COIIBCTIC01; DBOG IBOSB: CaSB
BIST01IBS
fatal o*«EdOM tcoi tcanylcycroain*.
d-bEOipbvnicaalu, d-laoapbvdcliw,
(co(K>syph*n«, alcohol.
55 yr oil ihlt* f»aal«.
IICOBOLS; IIICOTICSi DBDGSi E1000;
OBIIBi BBaXI; LIfEl: IBTIDBPnSSXf B
tCEITSi COIIICTICOT; DBOG IBOSE; CiSE
BISTOBIBS
UFEBBICE
EtMlt, B.C.
Sha«k». E.
oro»», B.B.
19T»
BaMlt. B.C.
Shaakan, E.
GEOM. E.B.
19TT
Wt
-------
2-(p-cbloro-»lph«- (2-(diMtkrl««lBO)«tkTl|b«n*yl)-
2-pyrldlB«prop«BaBlB». 9a«»-(<-chlocoph«nrX| -l,l-di»th]rl- (
\32-21-*
C16-B1«-C1-12
Si 2"»«,10. It 130-135 C (Ularglian) , BP 112 C at 1.0 » 89
* CI)
en
TISSSB
2W1
OclB*
BTfOSOlB ROUTE
IB9«*tlOB
»«»imC«l
KETHOD
IP IT
I01BEB
or c»sss
a
B1«CE
a) 1.19-0. «38 a9
b) 0.*35-O.S3i a9
c) 0.2W-0.161 *g
1BII
al O.»1« B9
b) 0.696 B9
e) 0.222 mt
•
t
a
c
2
c
P
1
H
O
e
a
C
g
crupiL nroniiTioi
I Chlacphaaicaalna
I WBOdaiaatkrl cklorpkaalcaala*, a
aatabollta
I Did««aSOBEHeiT RETBODS; CSIIE;
SITHOtlTIS; BBTlBOlISa
lal, C.fl.
Stoll, B.C.
Look, z.n.
Tacobl, 1.
1910
-------
fyrldlM. 2.6-«l««l»o-3-(pfc«iyU«o)- (• CIJ
94-TB-O
C11-I11-BS
II 213
tXSSSB1
2192
OclB*
_
BBfOSnB BOOTB
tuinzcii
BBTCOO
IOBB8B
or CISBS
6
B1MB
Bat gl*«B
-
»1.0*
... -
6BIIBU XlfOBUTXOB
61100 19 t«bl«t« of pk«uzapirl4iB«
kidcoeklotld*. t o( teM in M-kr
ItlB*.
6 kwltky BBla. «9«4 2S-«0 jiu.
CIOOS; BBUBOtXTBS; OBXBB; CIIID1
RTBBBBCB
._
CkutrtBd.'l!
1976
-------
lli. l-l|j-e«rbo«y-1-oio---(2-|2-tkl»«Tlt«c«tMl4o->-S-tkl«-1-«Mblcyclo(».2.0loet-2 -en-3-Tl)sethyl|-. hrdcoild*. Inntc salt (D CI) (»»•)
nUsI 1-(U-e«rto*y-«-cio--'-(J2-thI«ByUc«tyl|«ilno)-<-tfcl«-1-««ibieyelo(«.2.0|oct-2- •»-3-yl|«»tkyl|-. »Y«ro»lde. inner salt. (6S-tran«)- (« ri|
«fl-S9-«
C1»-Hn-13-1»-S2
n tis.so
TTSSOJ
21*3
OcU*
KIPOSnPB BOOTt
Injection
HULTTICXt
HKHOO
...
McrobiologLcul
(CUBES
or cts is
10
B»»G5
a) 30t-*OS M
b) 25»-367 >g
al 35) *1
b| 31S «q
-------
Pyrldoxol (8 CI)
J,*-Pyridiaedlsethanal,
6S-23-C
C8-B11-1-03
Bf 169.18, IP 160 C
S-hyaro*y-6-setkyl- (9 CI»
TTSS0B
289 •
Blood,
plasu
2895
Orlne
IXPOSOBB IOOTB
Inge at ion
XngvatloB
imniciL
METHOD
nicrobiologlctl
Bn Kyi title
HiccobioLogict 1
floor oMtry
IDBBI1
or CISBS
s
s
BHOB
t) 3. 5-1.0 neoles/dl
b) 1.8-25.8 neoles/dl
c) 0.5-1.0 nxoles/dl
4) 0.f-».8 neoles/dl
a) Rot given
b) lot given
c) lot given
mil
a) lot gin*
bl lot applicable
c) lot glT*a
«) lot applicable
a) 51. S » or - 6* of
doie
b) 53.3 » or - 6.8*
of ao«e
cl 59. 9 » or - 20. 6«
of dose
GBBEUL IirOIHlTXOI
•) Total B-6 0-8 ht at a pyrMoxine
dose of 0 eg (con t col)
b| peak lacceeente above ptedoee,
total B-6 for dosee of 0*5—10 eg.
linear celatlon«al[ betneen total B-6
and doee o»«r tble caige (P<0.01).
Peaks 0.1-1 br. c) pvcldoxal
pkospkate levels 0-8 he at «
picldoiiae dose of 0 eg (control) .
d) Peak incceeents In prrldoial
[kosphate 0-5 kc after 0.5-10 ig
pyrldozlne. Peaks at 0.5-1 br.
Cecllne inch sloner tkan total B-6
Istlnates fron grapks.
Bealtky sen, 2«-32 yr old, ot
B-6-controlled diet and fast«d before
and after dose.
•mails; nnuotisB; BWIBOIIIBS:
ICOtTS; BLCOC PLISBl; OBXIB
• ) after 25.8 anolas 8-6, dond «lth
pyrldoilne. S. 7* cf dose excreted as
1-6
bl after 25.8 anoles B-6. dosed nitk
pyrldoueine. *.T\ of dose excreted
a« B-6
c) after 25.6 moles B-6, dostd vltb
(jrldoiol. ».6t of dose excreted as
1-6
Bean total 21-hr excretion or B-6
plus k-pyrldoxlc acid after
-------
•yrlsldine. 2,»-diaelno-5-(3.».S-trlsethoiyben*yll- (* CI|
2,*-»yrieidimdia«iM, s-((3.«.i-trisethoxyphenyi)sethyi)- (9 ci\
738-70-5
CU-«1«-M-01
M 2*0.32. IF 199-301 C
TISSUE
2H96
Blool.
serae
flood,
serna
ETPQSOBS MOTE
IBgestion
Too*It lot
rlaoroaetry
Fluoroaetry
lOKBM
or CISBS
B»BC«
3.2-5.5 ag/al
lot applicable
*ot applicable
1«.6 aq/1
lioq« of a«tn» 2 he aft«r dow, d«y 1
and 9. S.O oq/al on d«r 12. *nd of
tclal. Dose, 20 ifAf/day
tciMtkopcli «ith 100 ag/k.T.
reldsan, S.
Chaidhary, s.r.
Ossi, a.J.
coi. r.
Sanyal, S.K.
1978
Hoppu, K.
Partanen, S.
Koskela. E.
1940
01
O
-------
rrrlildo(1.2-» lndol-10-ol,
3T7S1-39-6
C17-B1S-C1-B2-O
II 298.79
10-(3-chloroph«nrl)-2.3,«,10-t«tr«by *<)*m 29 pla or
llnai 13 ill.
t* incut tpp*tlt«
tlTIDEPlBSSITS lOBRSi OIITBC
EIBGOOB; DBOSS) D100 TBBBtPT;
CCBPIBtTITE ET110I1IOIS; II HTtO
tllLTSIS; BICOD CLISBI; PSICBOtlOPIC
Dioes; naioioeic BIHPESUTIOIS
BBFBIBICB
Ok. T.B.S.
EhlUalUh. R. S. B.
Ulakton. 8.
KlrtT. "-J-
1979
-------
Cnactz (i CI)
Quactx CS102] (« CI)
C2-S1
1» 60.0". !IP 1>23 C, H<> 2230 C
Tissue
21QH
Lung
2900
lung
EIPOSVR*. ROUTE
AMLTTICIL
RETROD
X-ray detraction
H
ES
POR8EB
OF CISSS
30
30
0.02-0.75t
20-150 ag/100 9 dry vt
O.ZOt
200 ag/100 g icy vt
e of 2 g ground, deled long*
Sections of lungs CEOB subjects vho
had b««n bituainoaa coal ainccs foe
J3-50 re-
SITtLS; TBUCI 8LE1IITS: tLORIIIOII;
CIRIOH; BFITILTOR: 80ROW; CHfO!IIOII;
CCPPEI; GimitUB: IROI; LElC;
HniESIOB; gilGAIESE: HCKEl;
sutcoi; SIHEB: Til; TlTinqa;
vmoxoi; Loncs; coil; O»IT»C STITES;
ai»IB»LS
Sections of langs (coa subjects vho
had been bitaainoas coal ainecs foe
12-50 re la Paleigh Coanty, lest
flcglnia.
TIUCI ElEBEITS; COtL;
• IRILLIOII; COBILT; CBR01IOS; COPTER:
XIOI; LEID; 11GIESI08; DtlGalESE;
IICKEL; TIT»II01; TalaDIOR; II »C;
ION1S: COHPHBITHB BfHOlTIOIS;
siLict: QDtm: LTBPH IODES: VEST
maim
BEFE'ECCE
ccable, J.T.
Reenan, E.G.
•olovlcx, T.R.
rnott. l.J.
Rolti, J.L.
Gocskl, T.H.
Keenaa. B.C.
Ceable, J.T.
Saallvood, l.».
Caclbecg, J.P.
1071
ro
-------
Oslnldlse (8 CI)
ClnchOBan-9-ol. 6'-«ethory-. (9S|- (9 CI)
S6-S4-2
C20-B2*-I2-02
91 32*.«1. IF 174-175 C
TISSUE
2901
Blood,
plasia
2902
Blood.
soena
2403
Orlne
BXMSOBB BOOTS
Ingestlon
Ingestlon
Ingestlon
1I1LTTIC1L
HBTBOD
Flaoroaetry
Maoronetry
'laoroietry
BOBBBS
or CISBS
20
8
8
UBGB
a) 16.8-585 119/11
b) 24.5-329 ng/al
a) 0-1.96 09/1!
b) 0-1. ^3 09/11
a) lot given
b) Wot given
IBM
a) lot given
b) lot given
a) lot given
b) lot given
al OS. 3 » or - 8.S 11
bl "0.8 • or - 7.7 a?
IIFOBBMIOI
a) Lo« and peak, 0.25 and 36 hr after
200-sg gainldlne agitate. p«ak at 1
he
b) Io« and p«»k, doav-corccctcd, 0.25
and 36 he aftu 330-19 qoinidin*
9l*conat«. t*ak at 6 kc
CartM for indlvidaals hara 2 paaks
foe 9laconat«. salts haT« «9iial
bloavailablltT.
20 hoalthy »olont««rs «g«s 21-St yr.
CI03S; DIOS TBBBkPT; 1DDLTS;
aissooai; OT»B; BLCOD PL*sat;
CORPHkTITB BTatOlTIOIS;
ItOSOBOSCOLit DISBISES
•) 0 and 1.a7 he. fasting baton and
attar doi«. 0.13 09/1! at 3C hr,
tlnal >ala<
b| 0 and 2.(1 he. costpcandlal dose.
0.13 <9/al at 30 he, final T«la«
•ange of avans aftae 400 ag as
silfata. Zstlaatad feon gcach.
etalthf sabjtcts, 28-33 ye, to other
••dlcatlon.
laosoa, l«thac9T, nasal congestion,
eapld neaet eat«, dlaeehsa.
HOGS; klTItlBBTTIHC kOBITS; BLOOD
SIBOH; »DOITS; CONPtBHTTTE
ITILOITTOIS; ORIIB
a) Tasting bafoc* and attae dosa
b| Postpcandial dom
casalatlfa aiccetlon extrapolated to
Infinity feoi •»-hr cate. let
different, f>0.05.
(•althy subjects, 2K-33 ji. no other
•tdlcatlon.
•aasea, lethargy, nasal congestion,
rapid heact rate, diarrhea.
MOOS; KTUBBRITHPIIC »SBITS; 8UOD
SIIIH: IOOITS; COHP»B»TTft
EMLOkTTOIS; 08TIE
BBFBBBBCB
CoTluky. J.o.
Basso, J., Jr.
Kelly, R.I.
Cashwn, J.
tslck. B.I.
Bason, «.D.
1979
loo. E.
Cceenblatt, D. j.
1980
Ul
U)
»oo, E.
Greenblatt, D. J.
1980
-------
;nUollne, •>-cnloro-e-((»-(4iethyla«lno)-1-»ethvlb«tTl|a»ino|- (X C
l,*-p«ntanedlaelne. »<«»-r-chloco-«-qulnoUnvl)-»C1|,»<1)-<»lethyl-
c1-03-7
CH-H2«-Cl-«3
*» SI"".**, If ••• C
Bloort,
sera*
sxposnss ROOT*
Ingestion
UM.TTICIL
SBT10D
Fl«ocoi*tCT
"OKBES
Of C1S?S
100
b) 0.
c) 0.
d) 0.
•) >
BUG;
.2 uq/al
-0.3" ug/iL
-o."'** og/el
c * 0.9 ug/al
«x»
a) tot given
b) Vot given
c) Vot given
d) lot jlven
el Hot given
GEIIEItl IIPniHTIOK
•I 6t of patient*
b| 101 of patients
c| 2~<\ at patient*
d) nt oC patient*
•I 101 of patient*
Fatient* on 0.25 g/dar > 1* day*.
Fatlent*, age* 23-1* re, at
chenatolcgr clinic
fieqaencf of aide effect*, (vl*ual
and central nervout *r*tei
distecbance*. confasIon In 1!*)
incnaced Kith *eca* level.
DRUGS; SltDBl; BHEOHTOID tllRKITTS;
units; irataiocic
BIOOD StBUB
rrlak-xol(berg, n.
8«rgkvi«t. I.
Doerl]-l>rberg, 8.
Hell«tro*, L.
Janason, F.
Ol
-------
tlbofllTio
83-88-5
C17-B20-B4-06
If 376.36, 81 278-282 C <4«cc»p)
TISS«B
2905
Qcii*
BIFOSOBB BOTH
-
1BURXCU.
NBTBOD
BOBBBB
OP CIStS
187
SWOB
•) Bat giT«n
b| lot glT«D
BSkB
•I 1396 ag/g
cr««tinin«
b) 2661 «g/g
crMtlaln*
0»«Ii»L IIFOB8KXOB
... -
• I Mn
b) IOMH
Cilt«ct« foe lo« !•*•!• < 80 ag/g
en«tlBi>«.
>or«l atahni, 58 mo, 129 «ann. M«n
•g« 69 jr.
DIETS : T11CB BtBBBINt CBOLB5TBBOLS;
tlOOP SBBOR; UK; COPPEI; 'CT4S3IIJB;
SODIOPI: S»O»IStDll; ClLCtBR; IBOB;
fllHH 1: VniBTBS
IBFBBBBCB
Maker, s.
mndricki, o.G.
B*haa*T> *•••
1978
01
-------
luhldUe
1 (100-17-1
n
It! H5.«S78, IIP 31 C, B? 688 C, TP 10 •• Bq it 390
7TSSOB
2906
\orta
Blood
2901
Hair
2909
Kidney
2910
Li Tec
.
E IPO SORE ROOTS
--. . .
KVkLTTTCAL
1BTHOD
I-ca* spoctroa
n\
«
I- cay .ipectroi
I-cay *p*tctcoB
fORBEsI
OF CaS35
6
a| •'1 2
b) 691
11
12
10
RMGE
lot given
a) lot given
b| lot given
0.20-3.ao ppi
a) lot given
b) lot given
lot given
|IIR
lEtl
9.09 ppa dry «t
a) 15. • • or - 3.2
19/9
b) 17. e » or - «.0
"9/9
1.35 ppi
a) 19.0 ppa dry «t
b) 15.5 ppi dry «t
13.0 ppi dry vt
MSB)
GERIBIL TIPOBBtTIOl
7 saiplea pec case. 2 analyses per
saiple.
197t autopsies of 10 °laa Indians, a
Papago, and a Creek Indian.
fOTlSSIOl; CILCIOB; IRON; COEPES;
ZTIC; ROBTDIOB; IICREL: LEAD; RCTALS;
TUCB eiEDCITS; LITER; SPLEER; IORTA;
lIOlrYS; IOIEOS1 TISSUE; PIICRBAS;
BEISORE1EII 1ETRODS; IOTOPSTIS
a) Haternal
c) Fetal
Dcy «t basis
Saiples (toe * hospitals in
laahvllle. TR.
PUCERTI; IIEIILS; MICE ELERIITS;
IIIIESSEE; SlOOOl BIIR; COBPIRATITE
ITaUUTIOIS; SEBCDBT; LEAD; CADHIOR;
SILEII1«: ROBIDIOS; IIOI; TIIC:
COBALT
Scalp hale
Conors froa 2 villages of Haika
Indians in the tsazonas Territories
of Tenezaela.
BIIR; VEItZtlEU; tIETILS; TIUCT
EIE1EITS: SODIOH; ILORIIOR; SItTCOB;
CILOIIIE; POTkSSIOR; SCIIDIOt:
1IIIIIU1; TIIIDIOH; CBBOCIOS: GOLD;
EIIGKVESt; IROI; COB1LT; IICIEL;
CCPPER; XIIC; aRSEITC; SELEIIOB;
EROBIIE: ROBIDIDR; STIORIOH; SILVER;
IITIROIT; IODIIE; CESIOR; BIIIOR;
UHTHMIH; CEIIOH; SIBIRI05; HEKORT
a) wdnlla, 11 of 12 cases
b) Cortiz, 12 cases
2 saiples per case. 2 analysis per
aaiple.
197a autopsies of 10 Pica Indians, a
Papago, and a Creek Indian.
POTlSSItH; CILCIOB; IIOI; COCPBI;
tllC; ROBIDIOPI; IICKEL; LEID; BETllS;
TRACE EL1HEIIS; LITER; SPLEER; IOITI:
RIDIETS; ADIPOSE TISSUE; P1ICBEIS;
HIISOREIIIT BETBODS; IOTOPSIIS
sasple.
K7I autopsies of 10 Pin Indians, a
Papago, and a Creek Indian.
POTISSIOS; CALCIOB; HOI; COPPER;
XIIC; R01IDTOH; IICKEL; IBID; HETALS;
T»CE ELEREIIS; LITER: SPLEEI; AOITA;
IIDIETS; tDIPOSE TISSUE; P1RCBBIS;
BIISOIEIIEIT BETBODS; IOTOPSIIS
" -n5SiHc5 —
Kangalson. l.f.
Rill, n.«.
Rielson, U.K.
Eatongh, D.J.
chrlstensen, J.J.
Izatt. R.H.
Richards, D.o.
19^9
P-aglan. P.J.
Brul, ».B.
Schulert, ».
•ilson, D.
Larsen. K.
Dyer, 1.
Hansour, H.
Schaffner, 1.
Boffian, L.
Davles, J.
197a
Perkons. >.K.
Telandla, J.J.
D lanes, H.
1977
Rangelson, N.r.
Bill, H.w.
Rielson, U.K.
Eatoagh, D.J.
Christensvn. J.J.
Izatt, 1. H.
Richards. D.o.
1979
Rill, H.I.
lielson, U.K.
Eatoagh, D.J.
Chrlstensen, J.J.
Izatt, R.B.
Richards, D.O.
1979
-------
lubldlas
7MO-17-7
It
Itf 85.»678, HP 39 C. BP 688 C. fP 10 » Hg at 390 C
(COITIHED)
TISSUE
2911
PanCCaaS
2912
PUCamta
2913
splmn
2»1«
Orlna
EXPOSOIE BOOTS
alaLTTXML
HBYROD
X-caj spectres
•I
I- cif spectres
11
IOBBEB
or CISES
«
1)26
1
•I 1
b| 1
mat
lot given
lot glten
lot given
•1 1.1-2.6 sg/2« be
b) l.V-2.61 sg/2« kr
mi
15. 51 ppi ifj it
25.0 » or - 5.8 19/9
22.2 ppi ACT «t
a) 2.0 «9/2» be
b) 2.09 t
-------
S-Stlfon»t« <»0 po«lU«» In CBEUI1B) .
TISSIH
*1.00d.
pltsia
BXPOSDB" BOOT!
HkllTICll
1ETHCD
K019SB
or rises
20 (80
Mlpl**)
BiKGt
a) lot glT»n
b) lot gl»«n
c) Hot alvvn
al I.1 n*>le»/»l
M 3.6 n«ol«»/il
c) S.3 niolis/il
GEIIBtL IIF3R»TI3I
a) 1 ppa at>oaph«clc SO2
t) 3 ppi atioapboric S02
c) 5 ppi ataotphiric 502
of data.
eialtky adalt nonsiolraci (i*an »g« 22
yd and siokm (i«an «g» la yr|.
ttOOD PLkSH>; SDtPDB; IE
ITttOlTIOIS
IOIK;
Caanison, I.P.
Psll««, E.D.
OO
-------
sillcrllc acid (8 CZ)
B«zolc meld, 2-kr«co«y- {9 CI)
69-72-7
C7-B6-03
II 138.12, HP 157-159 C, BP ibont 211 C «t 20 •• 89
TISSDE
2916
Blood.
plMH
BXtOSDIE EOOTB
lULTTICUL
RETBOD
Btdlontcr
I01BEB
or cuts
B1KS
a) 0.01-0.2* 19/100 il
b) 0.27-0.61 19/100 «1
e) 0.73-0.96 19/100 ll
d) 0.18-0.79 19/100 il
0.12 19/100 ml
0.*2 19/100 •!
0.87 19/100 •!
O.S1 19/100 »1
BEEiBai iiroMttioi
• ) 0.5 kc «ft«r 1 9 dOM
b| 1 kc «ft« 1 9 dom
c| 3 kc «ft«c 1 9 dou (p«ak)
d) 9 kc «ft«c 1 9 do**
Dem «•• of
2 |p-»laob«nioylox7) fcmrboiyl-CU ]bon
loic teid.
IITI-riFUBllTOBI IOBITS; IIUOESICS:
tiooo pLiSBi: unit; BETISOIITIS;
OB OSS
BEFEBEBCB
Smjth. B.o.
Folk. ».
DlMond, J.
Bnrni, 8.J.
197»
VO
-------
Salicylic acid acetate (ft CI)
Benzole acid, 2-(acetyloiy)- (« Ct)
50-78-2
III 110.2, IIP 135 C
TISS1B
2911
Blool.
plan*
?91R
Blood,
plasaa
2°19
Blood.
(hole
EXPOSURE BOOT!
Ingest ion
Tngestlon
Ingest ion
»I»LTTTC«L
RBTSOO
TC
IOH9ES
or ctsss
10
6
21
RWGB
a) Rot given
b) 10.22-17.10 eg/dl
a) 1.2-5.0 og/el
b| 0.3-t.S «g/el
c) 0.6-5.« og/al
d) 0.3-B.1 ag/el
•) 0.7-11.0 ug/el
a) Hot given
b) lot given
c) lot given
d) lot given
e) lot given
t\ lot given
g) lot given
HEM
_____ _ _ _ _ _
» 0.15 ig/dl
bl 12.6* ig/dl
a) lot given
b) lot given
e) lot given
d) lot given
e) lot given
a) 6. to ng/al
b) 6.26 og/al
c) 5. 90 ng/il
d) 5.7« og/al
e) 5.08 ag/el
f| 1.86 ag/il
q) 3.9« og/il
GEItltl IlfOBBiTIOll
•) vk 1, placebo only
b) Vk 2 and 3. day* *-«, 1.3 g
•iplcin t.l.d.
dose.
20 healthy aales, age< 21-50 yc.
1-10 told increase in fecal Hood
less ovet control feciod.
HOGS; DROG TREIIPT; FlORIDk; » DOITS;
BICOO PLtSRl) COHPlilTITE
EttlOtTIOIS; GISTRCIITESTIiai STSTEfl
_
al tftec high carbohydrate eeal
b) Uter high fat eeal
c) kfter high protein eeal
d) raiting
e) Fasting
C*0 eg dose elth 250 «1 or 2* al
(case 11 of eater.
Bealthy lalea 21-30 yr old veighing
6«-«i kg.
DtnnS; HETtBOLITES; BLOOD PtlSFU;
DIETS; 1ISCOISU
• ) 650 eg acetylaallcylic acid (1st)
• 650 eg acetaelnophen (»P»P) • 65 ag
caffeine (CF)
t> 650 eg »S» • 650 ag »P»P
c) 650 eg 1st » 650 eg IPIP • 130 eg
CI
d) 650 eg tS* > 325 ag 1PAP > 110 eg
CF
•) 650 eg iSl » 325 eg 1P*P
f) 650 eg »Sl » 325 ag »PIP < 65 eg
CI
g) 650 eg ts«
level! 20 eln after doeing.
DBOGS; BLOOD
BEFSREICE
Cohen, ft.
1979
Koch, P.I.
Schvltx, C.».
Villa. P.J.
HaUqniat. S.L.
Veiling, P.G.
1>)7B
Cotty, V.F.
Sterbenx. T.J.
Ruellor, F.
Releen, K.
Bderea. B.
Skerpac, J.
Ranter. D.
Lehr, R.
1977
-------
salicylic ecld. lan(1-| (8 cq
Benxoic acid, 2-hydcoxy-, lon(l-) (9 CI) (HI)
C3-36-S
C7-H5-03
1* 138.12, at 157-159 C, BP aboet 211 c et 20 mm Bg
TISSUE
2920
Blood
2921
Blood
2422
Blood.
plasea
2423
Blood,
plasea
EnosmB ROCTE
Ingestioa
Ingest ion
ingsstion
— __
alaLRICU
BBTBOD
2 •<)
(day «). Piroxlcaa given
ccocucrently.
1 healthy aalea
CIUIS; DBH1 THEKkPT; BLOOD PUSBk;
CCIIECTTCOT; tITI-IIFLtBBlTCIT
IQIITS; IlkLGESICS; COBP>I«TIVE
tltLOtTIOIS; 1DOLTS
BBFEIEICE
Bickers, 1.8.
Boberts. i.J.
1979
Pinkie, B.S.
BcCloskey, K.L.
Goodsan, L.s.
1979
Koch. P.k.
schultx, C.I.
lllls. I.J.
Hallguist, S.L.
telling. p.G.
1978
Bobbs, D.C.
Twoaey, T.H.
1979
-------
Salicylic acid, ion(l-) 2«
9loM,
••rue
2^25
'load,
SemS
2126
11004.
neaa
2<>2-'
Blood.
«bol*
XTPOSOB* tORTE
Ingeatlon
tnqeatlon
Tnqostlon
Ingest Ion
»I*LTTIC«L
nFTfino
HT
Colorlaetcy
'
"HB3JR
np CISSS
6
«
1
1
8 MICE
•1 126-225 ag/ml
h) 135-248 l(j/«l
•) 16.1-31.4 19/41
b) 13. «- 32 iq/41
lot aiT«D
«8-25.2 19/41
mi
•1 lot ()l»«o
b| lot gifen
a) 23.1 ig/dl
b) 21.S >9/41
380 19/1
lot gl»«o
CEIE»L IirODBlTIOl
•1 »(t«r 650 19 «r«rf » ht fct to hr
b) »ft«c 1300 19 at 0 tlaa ae4 a kr,
then 610 19 «T*CT be for ao tr
l€T«ls of ISO U9/il pco4ac«4 by 15 br
• Ith Ioa41a9 c*9la«n. >>T 30 tc "1th
educational c«9la«n.
Haalthy volootwrs. a«an aq« 23.3 yc.
••an «t 7a.6 kq.
1 subject c«Boct*4 tcan«i«nt
tlnnltaa.
CBDCS: DI06 IHMAPI;
»«Ti-iifnamtoit tcewrs; iiiLGtsics;
I»TIPT»ETICS:; arrtBoiiTEs; noon
SIIOH: TET»S
a) >-hc lnt«ci*l«
b| 12-hr interval*
•aan dally canq*, «»g 58.7 ig/kg/day.
3 aan. I noaan, 2*-S7 yc. Kith
cb«a*atold tcthritla.
Olid, contiBooaa tinnitus in 3
patients.
CF03S: DI06 taiUPIj 4 DOLTS; "LTOO
SIROH; C»tTFCB«I»i CORPtll?IU
IValOITIOIS; IREDHkTOTO HTHFITIS;
BISBaSU
ttter 2.5 9 In as he ai ointnnt
ipplifid to 9un. (*«coaa«nd«d dosage
«00 ag/«8 be)
21-ao old cblld
Saal-conacioos. apyreiial. dibydrata.
Pols*. 150/iin. Hblt* cell ceont
3«.000/al, acino atconqly poaltin
Cor katooas. Sacofacr «itblc M hr.
DIORS; OS DC TBtRiPI; CBILDIEI; CtSE
aisToii;s: gtooo stfosj OIITID
KIIODOI
liwlc toe 1C hr paclod duel eg second
day of hoipltallzation folloiiBg
accldantal Ingvation.
26 ao old
Tcaltlng, ccaplcatory difCicnlty,
apycacla, saraca aatabolic acidoaia.
llvaolar adaaa «ltb byalina »aabcanas
and inteacaplllacT flbrlnoas throabi.
OIOBS; OIOG IBOSI; CBILDRCR; BLOOD;
CIS! 8ISTOBIIS; BELGrOl
tirsHtm
Tnlhart, t.l.
laddan. T.n.
Vast. I.E.
19-"t
Cassall. s.
rurat, D.
Dcoagoola, S.
Paalac, R.
1
-------
salicylic acid, loan-) (8 eit
Banoic acid, 2-hydroKy-i loa(1-| (9 CD (»»•)
63-36-5
C7-H5-03
81 138.12, Hf 157-159 C. BP abort 211 C at 20 •• 19
(COnilUED)
TXSSDI
292S
Orl»
EXPOSOK 100TB
lDQ»tlon
tULTTICtl
SMBOD
»DBBE1
OF C1SBS
•1 S
b) 5
BlIOB
a) 330-395 mg/9 kr pniod
b) 215-126 19/8 he pnlod
RBII
a) 318 »g/8 hr period
b) 3(0 ig/4 he p«rlod
OIIEIIL inOIMTIOl
a| liaaat of
2-(p-aiiDob«iixorloij)(c*Ebox!l-1lc]b«
Diolc acid •ipc«u«l as •allqrelle
acid
b) iioaat of pacant coapoond
•ipr««a«d ao p-«iliob*D»n« acid
Baalthy adalt*
uti-iirLiimtoBi «ants; twuessxcsi
HOOD PUSHl! 011*1; 8KT»BO11TES;
DIOOS
UfBREBCE
Siyth, B.C.
Polk. I.
Dlaaoad, J.
Birna, a.J.
HcrcMo, T.
19-»»
UJ
-------
Salicylic «cl4, p->iltiob«nxoit« (8 CI)
Benzole «cia, 2-|(«-««laolMBioyl|oxrt- I' CI|
237S7-97-5
CM-B11-B-0*
II 257.26
TISSOB
2929
Blood.
EirOSDIE IODTE
- -
Ing* it ion
IIILYTIC1L
BBIBOD
UdiOMtrr
RoaBiB
or CISBS
3
BIMB
,..
n| 0.41-5.06 19/100 ll
b) 2.83-7.91 19/100 •!
c| 5.81-8.92 lj/100 ll
d) 1.»S-3.0« 19/100 ml
BBIB
•1 2.11 19/100 il
b) 5.70 19/100 il
ct 7.23 lj/100 il
d) 2.26 19/100 il
SEIKHL IIFOBBITIOI
•) O.S he ««t«r 1 9 do**
b| 1 hr l(t«c 1 9 dOM
c) 3 he t(t*e 1 9 dOM
d| « ht «tl«r 1 9 dOM
Kilth; idolta
IITI-IirLtRllirail lOEItS; tBILOBSICSi
HOOD ntSBI; 01III; HETABOLITES;
oiaos
BBFBBSICE
Siyth, l.D.
Folk. ».
Oitiand, J.
Barns, B.J.
B*CCS«9. T.
197*
-------
Salicylic «cld. 5-Mp-(2-PTrMTl««i*««orl.|pl>«nTll«lo)- (8 CI»
Btnzoic add. 2-hTiSroIT-5-((«-((2-prtiaiiiTl««l'>o) ualfonTl)ph«DTl)a*o)- (1 ci)
5*9-79-1
C18-B1»-B«-OS-S
•I 398.39, IP 210-2*5 C (tocmp)
TI3SOB
2930
OclM
BIPOSOIB BOOTB
lB9*stlon
l»»LTTIC»L
BBfROD
IORBI1
OF cases
6
I1IOB
1.»6-6.3M of torn*
SE1I
3.36* of tan*
_
OEIIIlt IWOIBITIOI
Camlatlr* t-dtf •iccction aft«c 2.0
9*
« kxltkr Tblifl, igvs 28-«6 Jt.
fut«i 8-10 hr twfoc* doling. 2
p«tl«Bt«. «9W 63 aal 70 yr, «ith
blind-loop sfndcoi*.
TMIHID; OIXIB; BIOOD PLtSBIi
BniBoitTBSi nriBousB; coaminTB
BVI101TIOIS; I001TS; DISBtSIS
unuicE
Thltkapindtt, t.
1978
Ul
-------
Siuriu
1MO-19-*
Itl 159.«. II 1072 C. »» 17T8 C
TISSOI
29J1
•air
•iromii toort
ilUTTIClL
inioD
it
lOHSEt
or CASES
11
I1MI
lot d«t»ct«bl«-O.OJ pp*
mi
- __
0.010 ppl
CtlEIIL IirOlltTXOI
Scalp k«lr
tmori (CM 2 Tlll««a of talk*
Miau !• tk« IMIOM* T«tcttocl«B
e( T«ni««l(.
IIII] TEftlOIll: IRtLSj ItlCI
ittnitii sonvii tLtimi; nticoi;
cnotittt rotusni; SC»DX*U
tITUIMt TI»DIIB; CUMIVIt OOLO;
iiKinsit noi; COIU.T: iicni;
ccrrti; me: unnc; scuinii
iionn; tinnoi; amoitmt sarei:
tmioiT; xoiiiii ccsiii: Bintu
tiintnu ctnns snuioi; IMCVIT
tzrziEicc
._
PtctOil, i.K.
T*lu4i«, J.t.
Dl««, 1.
1»T7
-------
74*0-20-2
Sc
Itf ««.9S5». I» 1538 C. » 2832 C
TISSOI
~ "
2932
•ftlt
inosni IOOTI
...
illLTTIClL
METHOD
II
... _.
I01BII
or CUBS
11
Jm ,.
1HGE
.
8.0068-0.0178 ppB
mi
0.0131 pp«
GBIEUL iiraiMTiof
SCBIP kali
CoBora from 2 wlllcgM of Mttt
IB
-------
Jelenlaa
7782-«9-2
Itl 78.96, It 170-217 C, IP 685 C. TP 1 aa Bg at 356 C. 10 aa Bg at «29 C
TIS30I
2933
Blood
293*
Blood
2935
Blood,
c«iis
2936
Blood,
c«ll«
2937
Blood,
plasaa
BIPOSniB 10011
Dacaal
lakalatlon
Ing* at ion
Ingaatlon
miRXCU,
IITIOD
.
U
Flaoroaetrr
,
Plaocoaatcr
101 MB
or cists
i
i —
al 717
b) C81
a) 10*
b) 71
c) 6*
at 10*
b) 71
e) 63
11IOB
lot applicable
a) Bot glT«n
b> fot gl*«B
a) lot given
b) lot givan
cj lot given
a) lot given
b) lot given
c) lot given
(•BIT
Utl
23 09/100 g
a) 1.10 » or - 0.28
«g/g
b) 1.0* » or - 0.29
ug/g
a) 0.07* » oc - 0.01S
ag/il
b) 0.0(7 « or - 0.019
ag/il
e) 0.069 • or - 0.016
ag/sl
a) 0.019 « or - 0.010
•g/sl
b) 0.036 » or - 0.01*
ng/il
c) 0.0*0 » or - 0.01*
ug/al
rtaB)
8BIIML IITOIBITIOB
ligast 1977
HE !•*•! of 3*02 gvucall} at oc
n«ir 0.2 ag/ci i.
*9-Ti-old choalcal plant nockac (1966
to 1975) «ipoMd to CdS. Mlmild*
dgat, BOH aolabl* cd coipoiids.
Tc«at«d (oc Pb polioning, 1965.
laultid*. Insoanli. llghth«ad«daa».
kaadaeha, laid* achai, joint pain.
[«c««th««ia la flng«r«. lapotonc*.
•Ignldcant might loai.
Blld ll»»r (BlacgaHBt «lth (oulblo
clcckotlc pattcra and calcl(l«d
gcaaaloaa oa left long.
BRIIS; CIDIIOI; IBID; SBiniUBl
ZIIC; BLOOD! OBIBI; KIDIBTS) IR11
FOISOIIIG) OCCOPITIOIU BIlifDS:
lOOLTS
a) aatocaal
c| Fatal
Dry «t baala
Saapl«« (COB * hospital* Lr
laahTllla. tl.
PlICBITt; RITUS; TI1CI ELIBIITS;
TIIIISSII; BICOD; B1IBS COBPHITITS
BliLOITIOIS; BBICOIT: tUD; UDBIOB;
StlBIIOl: IOBZDXOB; IIOI; (IK;
COBILT
a) locaal anbjacta
b) caacac patiaats
c) HoBcaaccc sacglcal patiants
laaldaats o( Otago, soath Islaad, lav
taalaad, «b«c« aoat acabl* laad has
lev coll S« content.
BB1US; SBLIBIOB; lltCB BLBBIITS;
B1000; BLOOD IliSIl; COBPlltlXVB
ITtLOanoiSj BIZTBIS; 1 OB;
UITBBOCTTSS; IBI TBUtBD
la*i««
BlfXBIi BBTJIS: TIICB ILEBBIIS;
COPPBB; BklSalBSB: SItBIIDH!
CIIOBXOB; inBOBIt FBIOSt BIOOD
niSBtl BITIIBOCTTES; BILK; 1ITBB;
OBITID MISDOB; lOTtlTIOIJU
DIFICXBICIIS; IBIIOTIC MOID
a) locaal aabjacta
b) Cancar paticats
c) loacancac mcgical patiaata
BaaldaBta of otago, soath lalaad, «•«
laalaad, vhaca aoat acabl* land has
lo« Sa content.
BZTtLS; SSLBIIOB; 111C1 BLBBIITS:
BtOOD; BLOOD PLaSM; COBPIBknTB
BTUOaTIOIS; IIITBES; aOB;
CBTTBIOCTIBS; IEI ZBUMD
IBFBIBBCB
lacner, S.
Hong, c.O.
Boiiaa, I.e.
1979
Baglan, B.J.
Bcol. i.B.
Scholart, t.
lilsoa. D.
lacaaa, K.
Or«r, I.
Baasoac, B.
Schaf(aac, 1.
Boffaan, L.
Davlaa, J.
197*
Bobiasoo, B.F.
Godfcay, P.J.
Thoaaon, C.D.
Baa, B.B.
fan U). i. B.
1979
Shav, J.C.I.
1980
Boblnaon, l.p.
Codfcar. P.J.
Thoaaon, C.D.
Baa, B.B.
»an Eij. I.B.
1979
ON
00
-------
Saloalaa
77B2-«9-2
3*
3*
at! 76.96, IP 170-217 C, BP 685 C, TP 1 aa HI at 356 C. 10 aa Hg at «29 C
(COITIIOBD)
nssoi
2938
Blood.
pla«aa
2939
Blood.
•hola
29*0
BlOOd,
•kol»
29*1
lair
29*2
Bait
IIP0301B BOOT!
Ingoatloa
I no* at Ion
Ingaatlon
IHLTTICIL
IBTIOD
.. _.
US
PlaOCOaatry
us
,
1*
BDBBBB
OP CUBS
•3
t| 10*
b) 80
C) 66
39
11
UBQB
13.3-2*. 8 0S/100 ml
a) lot gltan
b) lot 9l»«n
c) lot givaa
0.02-2.0 «g/g
2.15-5.»5 ppa
(IBIt
mi
17.1 09/100 ml
a) 0.060 » or - 0.012
•9/>l
b) 0.050 » or - 0.016
»9/»l
e) O.OS* » or - 0.01*
«»/•!
0.»6 «9/9
3.68 pp»
PtOC)
CBIII1L IIVOIBkTIOl
B«tl«l
BITIBI; BBtllS) T11CB BLBIBBIS;
COfPBt; BIBOMBSBi SBlBIIOBi
CBIOBIDB) IBIBOII; FITOS: BLOOD
HlSBl; BB1TBIOCTTBS; BILK; IITBB|
OIITBD KXIGDOB; IOTUTIOI1L
DtHCIIICIIS; tBBIOTIC FLUID
Participant* had llTOd la aru at
Kut 1 rr.
Population itadlad «a> froa Ian
Bcileo.
SELBIXOBl BLOOD; H1IB| Oil IB !
DIXIKM (Kill III BBSICO
a) loraal ••bjccta (16-65 yt old)
b) Cancoi pationts (a» ago 63 yr)
c) Ioncanc«c ncglcal patimta (a*
aga 53 yr)
loraal aabjacti >60 yc old had lo»or
lavala than tko«* <60 yr old
Strong cor relation botima 3a loral
and activity of Sa-eontaiolaq
9l«tathloB« pacoxldai* In aonal
albjacta and cancar patlanta
Inxyaa data a*allabl«.
laaUant* of Otago, Soatk lalaod, Ian
{•aland, «aara aoat arabla land haa
lev coll S« contant.
BlIlLSl SBLIIIOB; TIlCB ILBBIITS;
BIOOB; BLOOD PLISB1; CORPiBlUTB
K1LOUIOIS; Bill BBS! »««!
IITTBIOCITES; IB! IBUHD
Participant! had llnd In team at
laast 1 yc.
(opalatlon atadlod »a froa !•«
aailco.
SILBIIVI; BLCOD; BtXB: OIIIB;
DIXIKII8 UltB: III BIXICO
scalp hair
Conora fcoa 2 *illag*« of lalka
Indiana In the laaionaa Tarritorlaa
of fanaxaala.
Bill; fBIIXIIIU; BFtHJ; TBaCB
BIBBBItS; SODIOB; 1LOHIIDB; JIIICOI;
CILOIXIBi fOTaSSXOB; SCllDIOf;
lITtliaBi VII1DIOB; CBIOBIOB; GOLD;
BIIQIIBSB; IIOI: COBILT; IXCIBL)
COPPBI; IHC; 1BSBIXCI SBLBIIOB;
llOnil; BDtlOIDBl STIOIIIOB; SILTBB;
lITIBOIT; IODIIBI ClSIOa; BtBIOHi
IIIIHUOB; CEIIOB; SIBiBIOl; BBtCOBT
IIFBIBICB
Sha«, J.C.L.
1980
Valaatin*. J.L.
Bang, B.C.
Splvay, 6.1.
1978
lobluon, B.F.
eodfny, P.J.
thoaaoa. c.D.
Boa. B.B.
»an IIJ, a. a.
1979
falantlna, J.L.
Bang, I.K.
Spiny, 6.R.
1978
Parkona, I.I.
Tolandla, J.I.
Dlanaa, B.
1977
vO
-------
3a laulna
7782-«9-2
Sa
»t» 78.96, BP 170-217 C, BP €85 C, f» 1 •• 89 at 356 C, 10 •• 19 at »29 C
(COITIIOBD)
TISSUE
29*3
Balr
29M
Bilk
29*5
Placaota
29«6
OrlB«
29»7
Ortn«
EIFOSOBB BOOTS
Ing* «t Ion
tBALTTIClL
BBTHOD
US
It
us
It
IDBBSB
OP CISES
•I 260
b| 186
82 2
35
•1 1
b) 1
11 101
•1 0.025-1.65 09/9
b) 0.025-1.58 ug/g
lot gi*«n
21.5-203.0 19/1
•) 36.9-18* ag/2» kr
b) 19.5-27 ug/2» kr
RSal 1
a) 0.320 99/9
b| 0.303 09/9
Gcoiatric aaaas
1.70 » or - 0.61 09/9
79.3 »9/l
a) 66. a 09/2* kr
b) 23.2 «g/2» kr
GBIIliL IIPOIItTIOl
a) Children
b) »dalta
Bigaar Sa larala ID aaokara than
ocaaaokara. additional data.
scalp kale, Caacaalau la II. agaa <1
to graatar than 51 yr.
SITUS: TBaCI SLBHBBTS: BUI OB;
(OMB; CaDlIOB; CB10BIOB; COFPB*:
IIOI; LBICi LITBIOB; BIIQtlESE;
BIBCOBTi BICBBli SEIEIIOB; SXtTEJI;
TIB; TtltDIOB; ZXBC; Salt; aSB;
ICOLTSi CBIIDBBB; SIX; COBPIIaTITB
ITUOtTXOBS) DOST; SOILS; Uf
tOttOTIOl: OlBtl IBMS; BBB TORI
lITIBf; BETalS; TBICB B1EBBI1S;
CCPPBI; BUOIIBSB; SnniOB;
CBIOBXOB; IEIB01I; PBTOSj BLOOD
PlISBa! MITBROCITES; BUKi IITB8:
OIITEO SIIODOB; BOtlXTXOIat
DtPICTIBCIBS; »BIIOTIC ftOID
Dry it baaia
3aipl«a (roa » koapttal* In
laaavlll*. TB.
PlICBITt; BITUS; TtaCB BLEBtBTS;
TEIIE53BB; BLOOD; BaXI] COBPItaTXTB
SHLOlTIOBSl BSICOBT: LBID: C1DBIVB;
SltniOBj lOBXDIOl) IIOI| IIBC;
COBtLT
Participant* had Iliad in araa at
laaat 1 yr.
Popalatlon atadlad >aa fcoa B*>
Bailco.
3ILBIIOB; BLOOD! Bill!
DIIIIIIQ ItTR! Ill IIXXCO
a) Baal thy aal*. 6 aaapl«a owr 9 ao
b) Baaltky taiala, 2 «aapl«a 10 ao
aiart
Iddltlonal data avallabla.
BltUSt TBICB SLEBBITSl tBSIBXCS
BBOBIfSi CllCIOBl CBLOBIIBl CO BUT:
cnoBXOBi cssiOBi coppit: IBKOITI
IOCIIB1 POtaSSIOB) BUatllSB; SOOXOB)
BOBIDIOB; SlUBXNl RBC| OHBB|
BIlSOtBIIBT BITBODS
BEPBIEICE
craaaon, J.f.
Blooara, T.I.
Baagacixc. J.B.
Pinkarton, C.
1975
Ska*. J.C.I..
1980
B«9lu, I.J.
Bcul, a.B.
schalact, a.
fllax>n. D.
larsm, K.
DT«r, B.
Unaoac, B.
Schaffnar. I.
BofCaaa, I.
DaTiu, J.
197*
•vl
o
Talantlna, J.L.
Rang, B.R.
Splvay, 6.B.
1978
cocaalia, B.
Spaacka, a.
Boat*, J.
1975
-------
Silica
7C31-6C-*
02-51
it 60.08, IF 1610 c. n 2230 c, n 10 •• sg at ma c
TISSOB
29*8
tang
29*9
2950
LQBQ
2951
Long
f
IKFOStm tOOTl
allLTTIClL
BCTBOD
X'Cay apactcoa
IOBBBB
or cis is
a| 30
b) 26
O 23
dl 21
a) 16*
b| 1*
1*5
2
IkBOS
a) 20-*50 ag/100 g dcy at
b) 30-560 ag/100 g dcy it
c) 50-fO ig/100 g dcy at
d) 13-750 ag/100 g dcy at
a) 0.17-0.21 g/100 g dcy
at
b) lot giten
lot gltaa
a) lot givaa
b) lot giten
(list
nu
a) 200 ig/100 g dcy
•t
b) 206 ag/100 g dcy
at
c) 172 ag/100 g dcy
it
d| 203 ag/100 9 dcy
•t
a) 0. 19 g/100 g dry
it
b) 0.0* g/100 g dcy
it
0.20 g/100 9 dry it
a) 25 pactlclaa
b) 12 pactlclaa-
MOB)
OBBEBIL IMOBBHIOI
a) tpcll aad Bay 1965
t) Barca 1966
c| Dae 1966 to Barca 1967
d) lot 1967
additional data atallabla.
SectlOM of langi froa •object* iko
kad been bltaalaoaa coal ulaacc foe
12-50 yc la lalelgk Conty, laat
flcglala.
BETUS; TBICB BLIBBBTS; COIL;
BIlILLIIIBl COBaLTl CBBOBIOBl COPPB1;
IBOBl tBIDt BaGllSIOR; UlSllSSBl
IXCrjL; TITIIIOBi tlllDXOB; tXBCj
IOB83I COHPUatltB BtlLOlTIOtS;
SILICa; QOlltl! ITBPR BODBS: IBST
TXIGIIII
a| Coal eloata
b| Coatcola
Stctiona of laaga froa dacoaaad coal
alaaca aad noa-eoal alaara froa
lalelgk Coaaty, It.
BITUS; TRICE SLBBIBTS; COU: STLIClj
BIBTLLIOBl CIBOBIOBl COPtBBi XBOI;
1I1D| 11BIBSIOH; RtlOalBSBl IXCKBl;
1ITIBXOB) T(B*DXOB| II«CJ lOIGS)
COBPIIITUB BtllOlTIOIS; IB31
tXIGXBXt
Iddltioaal data atallabl*.
Sictiona of langa froa dacaaaad laat
llcglala bltaaiaoaa coal alnara.
anuss TBICB BLBIBBTSI cou.; srtici;
BEIIlltOB; CEBOaXOB; COPPEB; XBOI;
1110; RiaiESIOB: RilOllESB; licni;
IinilOl; tlllDIOH; SXBC; LOMS:
CCBPlBlTItB BtHOlTIOIS! BBS1
tIBSIBIl
a) Caaa 1, SOO ptcticlaa aaalyaad
b) Caaa 2, SOO pacticlaa analysed
*.»f of pactlclaa la ale tlltara tara
ailica.
2 laldara: 1 ale-arc aaildar la open
acacaa, 1 ace neldet la confined
afacaa.
Caaa 1, aodarata noa-apaclfic lang
diaeaae alth obatcactlte and
reatcictite coaponenta. Caaa 2,
aetere raatrictita loag diaeaaa.
Interatitlal flbcoaia and dlipanad
•ggregataa of aacropkagea containing
dark broin and black partlcalatu.
BETILS; tLDHIIVB: CCCDPlTIOIlL
RltklDS; RtlSDIEREIT DETBODS; LdlGS
BBIIMBCB
Ivenan, l.g.
Crable, J.t.
Saalliood. I.I.
Carlbarg, J.B.
1971
--
5 net, D.t.
Croaae, I.B.
Crable, J.t.
Carlbarg, J.I.
lalnkact, l.s.
197*
Carlberg, J.B.
Ccabla, J.t.
Uatlaca, L.P.
lorrla, a.B.
Bolts. J.I.
Baaac, P.
loloiics, r.R.
1971
Stettlar. I.B.
Orotk, D. B.
Backay. G.B.
1977
-------
Silica
1631-86-9
OJ-S1
ftl 60.08, IP 1610 C. BP 2230 C. Tp 10 » (9 «t 1732 C
(COfTIIOID)
TISSOB
2952
lyaph
nod*
BXPOSOSB BOOM
a Batmen
BBTROO
RORBBB
or CISBS
•1 23
b| 13
_
BlIOB
a) 30-2*00 19/100 g dry
•t
b) 7«-1«B9 19/100 9 dry
lit
m*
a) T92 *9/100 9 dry
«t
b) 693 19/100 9 dry
it
GEItML IirOIRHIOI
a) 0«c 196C to Raced 1967
b) lo* 1967
Polionary hllar lyiph nodei team
nbjacta «ao had b««n bltoaiooo* coal
ilnara (or 12-50 yr In lalaigh, i»at
Virginia
BUHLS; TB1CB BLEHBITSi COU|
tiBnuroR: coBtH; cmonoR; COPPBI;
IIOI; LBaDj RtSIBSIDRi BtfCIIBSB;
IICRBL; I IT* 110 11 1 flliOIOR; UK:
IfllOS: COHPIBHXVB BTllUTIOUs
SXtICk; OOlill; LIBPR lOOBSj WEST
IIBOIIII
BEPEIBICK
Kvaaafif B.C.
Ccabl*. J.I.
Sullnood, ».».
Caclb*c9, J.B.
1971
•vj
NJ
-------
SlUcat* (la potting* in CRBBLIR).
TISSOB
2953
lung
EIPOS01E IOOTB
allLTTIClL
BBTHOD
Z-say •pactco*
- ._
•DBB88
OF CUBS
2
-- ...
11IOE
a) lot gi**n
b) lot gl>*ft
a) 31 partlcl**
bl 2« partlcl**
OEIIUL IIFOBBITIOI
- . _
*| can 1, 500 partlclw aaalyxad
b) caa« 2, 500 pactlclva analysed
l.9< of pacticl** la ait filter* «*c*
alllcat*.
2 »«ld*c«: 1 alc-acc «*ld*c in opan
•pace*. 1 ace i«ld« la confined
Cam 1. aodicat* aon-*p*clfic Ing
dloum «ltk ob* tract !*• and
cutcictiv* coaponcnt*. Caa* 2.
**•«• c««trlctl»* long dia*a**.
Intacatitial flbtosl* and dl«p*r*ad
aggc*gat«« ol aaeropkag** coitalalng
dack bcocn aad black pacticilat**.
BITltS; tlORXiai; CCCOP1TIOIIL
BlttlDS; BBiSOSBBEII BETBOD3; LDI6S
St*ttl*r. I.E.
crotb, D.B.
Backay. e.l.
1977
-------
Silicon
7MO-21-3
SI
It* 28.086. HP 1*10 C. BP 2600 C. TP 1 •• a? at 172* C
TTSSOE
2951
Bair
2955
Kid nay
2956
Ll»ar
2957
Lang
EIPOSOIB IOOTB
-
1IILTTICIL
RBTROD
li
ES
-—
BS
ES
lOflBBI
or CISBS
11
a) 130
b) 7*
cl 66
a) 91
b) at
c) 76
30
IIIGE
0.01-0.0% ppa
a) lot glvan
b) lot glTan
c) lot glvan
a) lot glfan
b) lot fllTa'B
c) lot gitan
250.0-1965.0 ag/9 dry it
(IBR
IBM
0.025 ppa
a) 1%.2 ppa
b) 21.6 ppa
c) 23.8 ppa
a) 13.3 ppa
b) 23.6 ppa
e| 22.* ppa
lot glraa
MOB)
GEIEBkL IIFOPSITIOK
Scalp hale
Conors froa 2 tillagaa of laika
Indiana in tha iaazonaa Taccitorlaa
of Vanazaala.
Bill; TEIEZOEU: 8ETiLS; TliCE
EIBBBITS; SODIOB; 11081108; SILICOI;
CRLOIIIE; POIISSIDH; SCilDIOE;
tITillOH; TIIIDIOB; CBBOBIOR; GOLD;
BIIGIIBSI; IIOI; COBkLT; IICBL:
COPPEI; XIIC; ilSBHC; SELEIIOB;
BIOHIIB; IOBIDIOH; 3THOITIOB ; SILTBB;
ilTIROlI; IODIIB; CBS IDS; BiHOR;
LIITRilOl; CHIOS: SiBtRIOl; HERCOBT
a) lo canal diaaaaa
b) lent* canal failaraa
c) Chronic nnal failures
a) dlffacant fcoa b) and c) , P<0.01
Talaaa aca dry »t baala.
latopaiaa at DC Li Boapital.
TIICE ELEHEITS; BETILS; 10TOFSIES;
CllirOBIIl; IIDIBTS; LITE!; SPLR.I;
CISBISBS; RtPESTEISIOl; SODIVR;
POTkSSIOB; C1LCIOH; fROSPBOBOS;
IIGIBSIog; C1DHIOH; UIC; COfPEH:
LIiO| IIOI; BilGIIISE; ILDHIIOI;
SILICOI; TIT1IIOB; COBiLT; IICKEL;
IOLTBDBIOR; Til; CBIOHIOI; S1IORIOB;
BlIIOB; LITBIOB; SIlfBI; TIIIDIOB;
ICIOI
a) lo canal dlaaaa*
c| Caconlc renal fallaca*
a) dlffacant fcoa b) aad c) , P<0.01
faloaa ac« ory >t baaia.
litopalaa at OCL1 Hoapital.
TltCI BLERBITS; HBT1IS; 10TOPSIES;
CILIFOIIIll KID IBIS; LITZI; SPLBEI;
DISBiSBS; BTPBBTBISTOI: SODIOI;
(CTISSIOB; CILCI0B; PROSPBOIOS;
BI8IBSH1B; CIDBIOI; UK; COFPBI;
HID; IIOI; RilOIIISI; iLOailDB;
SILICOI: TITIITOB: COBUT; IICKBL;
BOLTBDBIOB; Til; CB10BIDB; snOKIOR;
BlIIOB: LITRIOI; SIHEB; HI ID IBB;
EOIOI
Sactlona of langa fcoa aabjacta «ho
had baaa bitaalnoaa coal aintra foe
23-50 re.
IBTiLS; TBIC1 ELEBIITS; ILOBIIOH;
EllIOB: BntlLIOB; BOIOI; CHIOBIBB:
COFPBI; OBIBallOl; IIOI; LI1C;
BIOIBSI08; B1I01IBSE; IICKBL;
SILICOI; SI1TBI; Til; TnillOH;
TIIIDIOB; LOIGS; COIL; OlITIt SHIES;
OOIBTI; RIIBULS
BBFEBEICE
Packona, i.K.
Talaadia, J.I.
Dianaa, H.
1977
Indraprtslt, s.
ilazandac, G.T.
Conick, B.C.
197»
Indcapcaait. S.
Gonick, B.C.
197«
Ccabla. J.f.
laantn. I.e.
•olotlcz, r.l.
Inott, R.J.
Bolts, J.L.
Gocaki. c.B.
1967
-------
Silicon
71*0-21-3
Itf 28.086. RP 1*10 C, BP 26CO C. TP 1 » Ig at 172* C
(COITXIOED)
TISSOI
2958
SplMD
2959
nci««
BtPOSOIB BOOTB
Ingartlon
tlUmCH.
BBTHOD
IS
US
IOBBBB
or CISBS
_
a) 92
bl «2
c| 76
11
ItlGI
-
•) lot gl»an
b| lot gl«m
c) lot glTra
•) lot gl»an
b) lot givan
HSU
a) 27.6 ppa
bt *0.7 pp»
c) «0.1 ppa
•I 12.2 » or - 1.1
ag/oar
b) 16.0 * or - 2.6
•g/dar
atiBtii. xiroiRiTXOi
at lo c«nal dl««w«
bt >c«t* nnal tallam
c) ckcoalc c*atl falUc««
a| an« c) dtftennt, P<0.01
talma »t« ttj »t bull.
|gtop
-------
Sllrar
7MO-22-*
•9
Itl 107.86*. IP 960.5 C. BP 2000 C, VP 1 » Eg «t 1310 C. 10 >• Bg at 1S«0 C
TISSOI
2960
Blood
2961
Hair
2962
Rale
EXPOSURE WOTI
Daraal
Inhalation
klkLTTlCkl
BBTHOD
US
•1
BS
•OH Bit
OP CASBS
•1 6
b) 8
«l R
U| O
ai 8
11
a) 179
b) 108
c) 102
41 109
IkHE
a) lot applicable
b) 1.9-5.7 ng/100 al
Cl 1 1— ft • aa/IAA •!
| !• 1 O«* ^ff lUU BJL
1) 1.2-5.7 09/100 al
0.20-1.85 ppa
a) lot glvan
b) lot gl»an
c) lot givan
d) lot gi»an
Mil
al 1.8 ng/100 al
b) 3.6 ag/100 al
r*\ \ A na/IQA •!
C) J« O vy/ 'UU IJ.
d) 2.5 09/100 al
0.47 ppa
a) 0. 18 ag/g
b) 0.28 ug/g
c) 0. 18 ag/g
d) 0. 15 ag/g
Ovoictclc aeana
CEIIItl IIFOIB1TIOI
a) Saplofcd 1 re oc l«s» - 1 «lth
aaaaacabl* l«f*la
aaaaacabl* l«*ala
c) Baployad 5.0-9.9 re - 3 «ltb
anaucabia lafala
d) Baployad 10 or aora yr - ? vita
aaaancabla laiali
Saallaat datactabla !•*•! 0.6 ag/100
al.
29 caccaat aaplofaaa and 1 paat
aaployaa of aaall allTac plant In
apatata 1«« York, incladlng cfflca
sad labocatoif paraonaal. liaraga
• ga 3». 6 re.
Bya, noaa, throat, aad raapltatorr
tract irritation, noaa blaadl.
aaaaaa. baadacbaa. narvonanau.
tlradnaaa. changa In akin and «y«
color, dacraaaad night vlalot.
Irgrrla
>rgrroala
IBTaU; SItTBB; BLOOD; SKII DISBISBS;
CCCOPHIOIIl IKIRCS; 100LTS; IN
TCBR
Scalp balr
tonora froa 2 Tlllagaa of (aika
Indiana In tha taaionaa Tarritorlaa
of Tanantala.
Btlli TBinOBU: IETM.S; TlaCB
ItBBSITS; SODItIR: IIOHIIOB: SItlCOl;
CBIOBIIE; POtlSSIOB; SCHDIOC
1TTHI01; TiUDIOH; CBBOBIOB; GOLD;
IIISalESIi HOI; COBALT; IICBL;
COPPB1; SIIC; alSBHC: SZLEIIOR;
BIOBXIB; BOBIOIOI; STBOITIOR; StLTBB;
IBTIHOIT; IODIIB: CBSI01; 815108;
LllTBtlOR; CBIIOB; StRtBIOR; RBBCOBT
a) Rala childnn
t) Faaala cblldnn
c) Hala adalta
d| Paaal* adalts
Corralatlon bataaan Ig and a«x.
additional data.
Scalp balr. Caacaaiana in IT, agea <1
to graatar than 51 jt.
BZTalS: TBaCt BLBHBRS; BIBIOB;
EOIOI; CaDIIOR; CBIORIOR; COEPBR;
I 101; LB1D; LITRIOR; RAIGalBSE;
BMCOBT; IICIEL; SILEIIim; SILTBR;
Til; TalkDiai! XXIC; BUB; a«B;
IEOLTS; CHILDBEI; SBX; CORPiUTITE
ITaLaiTIOISl DOST; SOILS; kit
POLLOTIOI; OIBkl IBMS; HB« TOBK
IIFEBEICB
Boaanaan, K.O.
noaa, k.
Knn 4
ROD, 3>
1979
Parkoaa, i.it.
Talandla, J.k.
Dianaa, B.
1977
Craaaon, J.P.
Blnnara, T.k.
Baagarnar, J.E.
Plnkarton, C.
1975
(HIT piai)
-------
3li.ni
7MO-22-*.
»9
It! 107.M8, IP 960.5 C, IP MOO C, TP 1 •• Rj at 1310 C, 10 SB 89 at 15*0 C
(COBTIBDBD)
TISSOC
2963
KldSSy
296*
line
296S
lung
2966
Spleen
BttOSQBB BOBTB
IIILTTICIL
RBTBOD
BS
BS
BS
BS
BOBBBB
op Casts
30
1IIOE
s) Bot given
b) Bat given
o) Bat given
a) Bot given
b) Bot given
e) Bot given
Bot detect able- 2.0 «g/g
dry lit
a) Bot given
b) Bot given
c) Bot given
Bin
at 0.70 pps (13*)
b) a. 66 ppB (6«)
o) 7.C1 ppa (7*)
a) 0.70 pps (13*)
bl a. 66 pps (6*1
c) 7.61 pps <7»)
lot given
al 2.68 ppa (9*)
b) 1.02 ppa (3«)
c) 3.78 ppa (7«)
SIIUIL IBFOBHTIOB
a) 10 renal dlaeaae
b) lc«te renal failans
cj ckroBlc renal fallen*
Dry it basis
Percent of saaples with detectable
levels is indicated in pereatheaea.
Ktopalea at octl Boapltal.
TBICB ELEBEITS; BBTILS; AflTOPSIES;
CILIP01BII; BIDBBTS: LITEi; SP1BBI;
DISEIStS; BtPMTBISIOl; SODIOB;
fOTISSIOBl CILCIOB; PBOSPBOBOS;
BIOBBSIOR: CIDBIOB; SXBC: COIPBI;
KID: 110 1; BIISIIESB; UOBIEOB;
sincoi; TiTinoi; COBIT.T; IICIBL;
ICLTBDBBOB: TIB; CBMBIOB: SIBOBTI8B;
BIlIORi LITBUJS; SILVBB; TIBIDIOB;
BOBOB
a) lo ceBal dlaeaae
b) lot* renal fallares
c) ckronlc renal fallerea
Dry «t basis
Percent of aaaplea ilth detectable
levels is indicated in parentheaea.
aitopsles at OCLI Bospitsl.
TBiCE SUBSETS; BBTILS; IDTOPSIBS;
CILIPOI1II; HDIETS; LITIB; SPIBBB;
DISBISES: BIPE1TEISIOI; SODIOB:
fOTISSIOB; CILCIOB; PBOSPB010S;
BiaiSSXOB; CIDBIOB: II 1C; COFPB1;
LtlD) nOB| ailQHISE; I10RIBOB;
SILICOB; TITIROB; COBILTi BICKBL;
BOLIBDIBOH; (IB; CBBOBIOR: STBOITIOB;
BIUOBI LITBIDBi SIMEl; UllDIOB;
BOMB
Sections of lungs fros subjects vao
had bsen bltualnoua coal slaera for
J3-50 yr.
BBTILS; TBICt BLIBIBTS: ILUHIBDH;
EIBIOB: BBBTUIOB; BOIOB; CRBDBIOB;
COPPBlj QBIHIRTOH; IBOB; LBIt;
aioBBSiOB; aiisiiBSE; EICKEL;
SIlICOl; SIHBl; TIB; TITIBIOH;
TIBIDIOH; IONS: COIL; OBITEC STUBS;
QOIETI) HXBEIILS
a) Bo renal disease
b) Icete renal falluras
c) Chronic renal failarea
Ocy "t basis
Percent of sasples ilth detectable
levels is indicated In parentheses.
lutopsiea at OCLI Boapltal.
T.BICB BLBHEBTS; BETILS; 10TOISIES;
ciiiroiBii; siDiBis; LITBB: SPLEBI;
CISB1SBS; BTpnTEBSIOB: SODIOB;
POTISSIOB; CtLCIOB; PBOSPBOBOS;
BI8BBSIVR; CUDBIOB; niC; COPPEB;
HID; HOI; BlIQlllSE; ILOHIIOB;
SILICOI; TITIHOB; COBILT; IICKEL;
BOLTBDBBOB; Til; CBB08IOB; SHOITIOB;
eiBIOB; LITBIOB; SILTBB; TIBIDIOR;
E010B
BBniEICE
Indraprasit, S.
llexander, g.T.
oonlek. B.C.
197 a
Indrapraait, s.
llexander, 8.V.
Qonlck, B.C.
197B
Crable. J.v.
(teenan, B.6.
lolovlcx, P.R.
Kaott, B. J.
Bolts, J.I.
Gorskl. c.a.
1967
Indrapraait, s.
lleiander, 6.T.
Gonlck, B.C.
197«
-------
SOdlM
7MO-23-S
It
Itl 22.98977. IF 91.fi C, Br 881.» C. It 1 •• Sg at MO C, 10 mm Sg at S«6 C
TTSSOB
29C7
BlOOd.
MEM
2968
lalE
2969
IldMT
2970
tl»ir
BlrOSOBB BOOTS
IBalTTXCtl.
RRROD
US
... .
BS
BS
BOBBBB
or CUBS
187
11
l| 135
b» 7«
el 87
al 92
b) M
O 76
BaMB
a) Bat firm
b) Bat 9lTia
(88-2931 ppa
a) Bat glTin
b) Bat gl»«n
c) Bat gl»in
a) tot glrin
b) lot glTin
c) lot gl»«n
(IBIT
RB1I
a) 33» 19/100 al
bl 33( 19/100 al
1562 ppi
a) 10.000 ppi
b) 12.100 ppi
c) 11.500 ppi
a) 5880 ppi
b) «««0 ppi
c) 7030 ppi
PIGBI
GBIEBAL IBfOIBMIOl
b|
Celtic!* fat loir 1*T<1> < 31: 19/100
• 1.
liol Ottbn*, 58 HO, 129 •ann, IHQ
•9« «9 yc.
DIETS; IHCJ BLBIBBTS; CBOLESTBBOLS;
HOOD SBBOR; IIBC; COPFBBi POTISSIOR;
SCDIOH; RlOBESIORj C1LCI08; JBOI;
TITIBIE t; TltkRXBS
Sctlp h«tr
Canoe* froi 2 rillagts of ««lk«
InAiiu in tin t»ion» T«rcltocl»
o(
BUI; TBBBIOBU; SBTILS; TBtCB
BtBBEBTS; SODI08; UOHIBOB: SILKOB;
CUOIIIE: FOTtSSIOR; SC1IDIBB;
IIHIIOS: VkBiDIOR; CRBORIOR; GOLD;
B1B01B2SB; IBOB; COB1LT; BICBB1;
CCFFBB; IIBCi iBSBBIC: SBLBBIOR;
BBORIBB; iOeiDIOH; STBOBTIOB; SILTEB;
IETI80IT; XOOXBB; CBSIOH; B1HOR;
IIBTBABOH; CEBIOB; StHtBIOH; RBBCOBT
>) la
fc) lent* c«nil Ullira*
c) Chronic c«n«l f«llar«*
•I dlfficint team b) and c), P
-------
Sodloe
7MO-23-S
I*
I*
It! 22.98977, IF 97.82 C. BF 881.» C, TP 1 » Ig at ««0 C. 10 •• Rg «t S*6 C
(COITHOBD)
nssn
2971
Mil
2972
Spleen
2973
Tewtk
2971
Otlo*
2975
BrUe
IIFOSOIB 1OOTI
| aULTTXCIL
IBTROD
..
»
BS
US
U
I08BB1
or cisis
•1 SO
bl 50
e) 3»
d) 23
» 92
b) «0
cl 76
35
•1 1
b) 1
•1 6
b) 6
I1MB
•I lot glT*n
b) lot gl*n
c) lot gl»*n
4) lot gl«ai tg« of
father*, as jr. lotkeri, «1 jr. «3
ill* ehlldr«», 12-2* re "d 38 f«mal.
cklldr.B, 12-2* yr.
citcioBi sooioit lunsxaii uoanoB;
SOUOI; CHOUIIi fiUDIOB;
B1K1IB5B; CO»PBB: TBICI BIBBIBIS!
HOOD PIBSSOBB; IB! BOIIB1: 8BTUS;
mis
•I lo renal disease
b) Icit* renal Cellar**
c) Ckronlc renal fallare*
•) and c) different (><0.05), b) and
e) different (P<0.005|
falaes are dry «t fca*l«.
totopslM at OCLa loaplUl.
TB»CB niBBITS; BBTUSi (OTOPSIBS;
CUiraSlIa; UDIBTS; IITBB; STtBBI:
tisBasts: BTpntBisioi; sooitra:
POTkSSIOl; CaKIOB; PIOSPIOBOSi
B10IBSIUH; CaDBIDHi UK! COIPBI;
HID; IBOI; BlIOIMSBi U.OBITOB;
SILICOI; TIHITD8; COB1LI; IICKBL;
eoiTBDBiOB; Hi; CBMRIDR: snotTina:
BIIIOBl LITBIOB! SILTBH; TillDIOHl
BOBOI
Cambridge, Bl schoolchildren
IltCI BlIRIRSi 8ETILS; STtOfTIOH;
t!lD; SODIOH: BIOIESIOBj XIIC;
riOOIIDB) BaSSICROflnS; CHIIDItl;
1IBTH; BBaSOIBBEIT BBTHODS
a) lealtky aale, 6 •••pie* owr 9 mo
b) Bealtky feule, 2 Miple* 10 eo
apart
Iddltlonal data available.
BRtLSl TIICI BLE8IRS; IBSEIIC;
BIOBIII; CtlCIOR; CB10IIIB; COIUT;
CBBOIIDI; CBSIDB; COPPBI; BBKOBT;
IODIIB; POIaSSIDH; IIIGallSE; SODIOB;
BOBIDI01J SELBIIOH; ZIBC; OR1IB;
BMSOIIBIR BBTRODS
a) Hyperten«i»e patleits
b) controla
Bange of lean rates of clearance 0-1
kr and 12-2« kr after «0 aq.
Patient* «lth aevere kyperteealon <6
no. «ltk >a*calar coapllcatlcn*. ages
42-63 yr. noceal control*, ill
fa*ted.
DBOG3; DBDI5 TRER1P1; RIPEBTEISIOH;
CIBH1RK; PBOTBIIS; DIDBETICS; ORIIE;
1 COLTS; COnP»R»TME ETtLOtTICBS;
SODIDa
IBTBUICB
Ba*lronl, B.
lolrtyokann, S.I.
Pierce, J.o.
Sckaaicknla. 8.6.
1976
Indrapra*lt, s.
tlexander, 0. T.
Qonlck. R.C.
197»
Bradevold. F.
Bed*. 1.
laaenden, B.
Bakka*. T.
1975
Cornelia, B.
Sp**cke, a.
Boate, J.
197S
Andreaaen. r.
pedersen, 0. L.
Hlkkelsen, E.
1978
VO
-------
sodium. Ion (*•(•)•)>
173«1-2S-2
ll
It! 22.98977
TISSUE
297«
RIU
BICOSOIE BOOYE
IliLTTICIl
HBTBOD
IDIBBI
OF CASES
I1ICE
11-20 ig/ai
HEkl
.
lot glr«o
CEIIHt TirOIRlTIO*
lol«n In Biolnghai. BcUtol,
CacllU. Bdlnbucgk, *nd »«>cutl*.
SODIOI; rtnoixiB; IODIIB; Rsikis;
till; OIITBD HISDOa
^
BEFEROCE
Anon
1977
00
o
-------
Stain!*** *t**l
12597-S8-1
IIICT coRFosmoi onion 01 OIDETBMKBD
TISSUE
2977
Lnag
8XF030U IOOTE
1I1LTTICIL
•ETIOD
I-r«7 «p*ctcoi
-
BOBBBI
OF C1SBS
2
IIME
.
a) lot gi»*n
b) Eat 9t*m
ran
a) aoe particle*
b) 30 pactlcl**
OEEEEKL IIFOBUTIOI
•) cam 1.500 pactlcl** anal]i*d
b) Ca«* 2,500 pactlcl** aDalyi*d
83.9X of pactlcl** In tiltcct me*
>talnl«u at**l.
2 mU*c>: 1 ale-ace »*14*c in op*n
ipac*«. 1 ace >*ld«c la eonfla*d
•cac*>.
CM* 1, aod«cat* aoD'aptcific long
dl**a** «lth ob*tc«ctlf* and
ctatclctiv* coapontnta. Ca*a 2,
**>*c* cotclctlT* l*ng dl**as*.
Int*c*tltial fibto*!* and dlapacmd
a9gc*gat*s of aaccopbag** coctalnlng
lack bronn and black pactlcalat**.
BRILS: UOIXEORi CCCaMTIOEU.
BIIUDS) 8E1SOEBHBR IRBODSi LOIGS
St*ttl*C. I.E.
OCOth, D.B.
lackay, O.E.
1977
00
-------
Str«ptaaln«, O-3-««lno-3-d«orr-«lpti«-I>-glncopTr»no«jl- (1-»)-0- (2,6-aia»ino-2,3,6-tcia«oijr-«lph«-0-rlbo-h«iopjtc«no57l- |1-«))-2-d«Qij-, c- (9 CI)
D-Stc«ptaaln«, O-3-a»iBO-3-4«D«r-«lph«-D-qlacoprr»noijl- (1-6)-0-(2,6-aia«lDO-2,3,6-ttl4«olf-«lph«-0-ctbo-h«iopTC»no3Tl-(1-»))-2-a«oiT- (9 Cl)
C18-B37-B5-09
BB »«7.5»
TISSOB
2978
Blood.
MCM.
Blood,
••CM
BIt04Qftft fcQOTrt
-
Injection
.
Inject Ion
aBaLTTICIL
HBTBOO
Uccoblologlcal
i !•
BOBBBB
OF CaSBS
5
9
BaBOB
•1 Bot glT«D
b) Bot glfan
c) Bat glt«n
d) Bot glim
•) Bot given
f) lot given
a) 8.8-16.1 og/al
b) 0.10-0.37 ag/el
BBaB
a) 11.1 ag/al
b) 9.5 ag/al
c) 5.2 ag/al
d) 10.1 «g/il
•) 8.8 ag/al
t) 5.0 ag/al
•I 12.0 «9/«l
b| 0.22 ag/cl
CCIIBIL IIFORIUTI01
a) TlM S (In
b) Tla* 10 aln
c) TlM 60 aln
d) TlM S ain
• ) Tl» 10 aid
f| TlM 60 Bin
a (tec 80 ag doa« (a-c) or 1 ig/kg
Eaaltar adalts (2 Caaal*, 3 ul«|
*g«d 21-55 ft ana *t 5«-85 kg.
MOOS; UTIBIOTICS; BLOOD SBtOB
a) r«ak« aftat 120->g IT boloa.
raaki at ficat obaarTatlon (E alnl
b) 8 he aftar 120-ag IV bolaa.
Bocbldly ob«>« «oi«n vho had gavtclc
fcjp*M aargac}, ag«a 21-36, Mights
103-151 kg.
MOOS; IITIBIOTICS; BtOOD S8TOB;
atOttS; SOBCIBT
BEFBRCBCB
sttattocd, B.C.
Dliaon, S.
Cobccoft, a.J.
1971
Blooln, B.a.
8ano. B.J.
Griffin, S.O.
Baaar, 1. i.
Bococd, R.B.
1979
00
NJ
-------
Strontiai
1MO-2H-6
5l
It! 87.62. HP 957 C. BP 1366 C,
10 » Hg It 698 C. 1 •• Ig «t 7«Q C
TISSOE
2980
B*lC
2981
Mdn.T
2482
line
EXPOSURE BOOTS
IBllYTICIt
BRBOO
11
IS
BS
101 BIB
or cis is
11
BIIGB
Bot 4«t«ctlbl«-0.0»
*) lot glfw
b) lot gifiB
c) lot glY«
•) lot girm
b) lot gltm
c) lot gl*«B
8Etl
0.02 pp«
•1 1.51 ppi (6X)
b) 0.35 ppi (lOt)
e| O.M ppi (301)
I) 0.18 ppi (2*|
b) 0.31 ppi (31)
c) 0.50 ppi (1*|
(1BIT PlOt)
GSBCB1L TIFOBB1TTOI
Scalp hair
Conorm fcoi 2 villigi* of lalka
lodltu la th« liazonas T«ccltoci*i
of T«n«««l«.
Bill; TIIBinlU; RITUS; TB1CE
IllflllTS; SODZOl! U.DBIIDB: ilLICOB;
CB10IH8: POIlSSIOBi SCHDIOB;
tITIIIOBi T1B1DIOB; CRIOHIOH; COLO;
8IBG1IBSI: ItOIJ COBkLT: IICIBL:
CCtPBB; IIKi 1ISBIIC; SBLBIIOl;
BIOUBI; BOBIDIOB; ST10HIBB: SUTIB;
IBTIROBTi IODIIB; CBSIORI B1KOB;
tllTHlKTR; CBimi; SlRIIIOBi RBICOBT
•) Bo n»l
-------
Stroatlne
1MO-2I-6
SC
«tl 87.62. If 357 C. BP 1366 C, It 10 •• 89 at 896 C. 1 •• 89 at 7»0 C
(COIHIOEO)
TZSSOB
2983
SpltMn
298»
Tmtk
EIPOS01B BOOTS
.
allLTTICU.
RBTBOD
BS
US
IOBBEB
OF CiSES
BalGI
a) lot gl»en
b) lot 9lT«n
c) lot glT«n
26-132 fp*
BB»I
t) O.I* ppl (6X)
bl 0.39 pp« (SO
e) 0.59 ppi («()
67 pp.
GEIZBiL ZIFOBRiTIOl
•) lo c«a«l dia«a«*
b) »c«t« canal Callaccs
c) Chronic c«nal failures
Dry «t b»l*
(•toot of «Mpl*> tilth a«tect«bl«
lavcli Is indicated in p»«nth«MS.
latopil** at OCLI Bo»pltal.
IBaCE BLBIBKS; BBT1LS; iOTOfSIBS;
CILIfOBIU; KDIEIS; LITBB; SPIIEI;
OISEtSBS; BTPBBTEISI01; SODITO;
coTissioR: ciiciui: PBOSPBOBOS;
MOIBSIOB: C1DRIOH: UICi COtPBB;
HID; IIOI: BlieillSE; 11DHIIOB;
SILICOI; TIttllOB; COBILT; I1CIBL;
lOLTBDEIOI; Til; CBIOBIOB; STJOtTIOB;
IHID1; 1ITBIOB: SILTBB; TMIDIDB;
ICtOI
caabrldg*. Rl ichoclchildr«n
TltCE ElEDEITS; BBTaLS; SIBOFTIOB;
II»D; SODZOB; B16IISIDR; XIIC;
PLOOBIDE; RISSICBOSERS; CBI1DBBI;
T1ETB; RltSOIBBBIT HBTHODS
BEFBBEICE
lodcapcasit, S.
11* lander, O.T.
Gonlck, B.C.
197»
BradeTold, F.
Beila, I.
aasendea, 8.
Bakhas, I.
1975
00
-------
strontlua, iaotopa of ••«« 90
10098-97-2
strontlua, laotopa of ••«« 90
10098-97-2
St
Itl 90. ap 757 c. BP 1366 C. TP 10 aa Ig at 898 C. 1 aa Bg at 7*0 C
298S
mth
BIMSKIB BOOTB
Inhalation
Ingaatlon
iiiinxcii.
•BTIOD
IOBBEB
OP CaSBS
291 taath
BIBBB
a) lot glTm
b) lot glTm
c) lot glvan
BBll
a) 2.3729 pCl/g wa
b) 0.6280 pd/g aaa
e) 0. "380 pCl/g a>h
GBIII1L IlfOlBtTIOl
a| Mcilaon
t| 22-28 yr
c) >3» yc
Pooled saiplw, at«tag« •> te«th par
aaapl*. Othar data arallabla.
Math froa [aopl* U*lag la tovac
3il«aU in aoathMatara Poland.
SHOITIOfl: C1LCIOB; CBSIOSj
(OUSSIVR; IIOIOI50TOPIS; RBULS;
1IBTR; POlalD
IBFBBBICB
Sloniak, B.J.
Plcyna, J.
Palciynaki, B.J.
1977
00
-------
strychnin* (8 CI)
sttrchnldin-tO-on* (9 CI)
57-2»-9
C21-822-I2-02
IH 33».«0, HP 266-270 C, BP 270 C at 5 H Bg
TISSUE
2986
Blood
2987
Dcin*
BIPOSOSE BOOTH
AHLTTICIL
RBTSOD
...
IOBBBB
or cists
2
1
IIIOB
«.9-S ppl
lot «ppllc*bl«
HEM
S ppl
9 ppl
GEimL IirOBBtTIOl
(ciioniag fitalitl««
PI3TICIDBS; USEIIC; JLKILOICS;
CIIBOI II01GIIIC C09PODID5; BiOOD;
IITZB; KIDUIS: Bill; 081 IB; LOIGS;
BIIBT; SPLBII; BBIII; BIOOD SEBOB;
TtllESSBE
Poisoning fatality
(1ST1CIDBS; IBSMICi tlXHOItS;
CiBBOl IIOBOinC CCHPOOIDSi ttOOO;
lT*n; KIDIIIS; BUS; OBIIE; LOIGS;
BIIBT; SPIEBI; BBtll; BLOOD SEBOB ;
1IIIESSEE
BEfEBUCE
Bay«s. i-J., Jr.
Taugkn. U.K.
1977
Ray«s, I.J., Jr.
»«oghn, I.K.
1977
_ ._
00
-------
strr«m (» en
ImnM. «tkuyl- (9 CD
IOO-M-5
ce-ia
it io«. 11, M -31 c. ar i«s-i»« c. TP 39.» «t» *t 37*.» c
TISSUE
2988
Blood
EXtOSOBB BOOTB
kllLTTIClt
BETHOD
IORBBB
OF CASBS
BIBOB
UAI
6EIBB1L XlfOBBHZOI
••Vi>V
lEflEI; STTBIIES; BBTH01ISB;
BITlBOLItBS; BLOOD
ISrEIEICE
Lcibun, K.C.
197S
00
-------
Sncclnailc acid, 3-aelno-l- (alpha-carbotyphenethrU -, l-ntkyl ester, atereolaoaer (6 CII (Til)
1-Paenrlalanlne. l-L-alpha-aapartyl-, l-Bathy! ester (9 CII
22839-B7-0
CU-B16-12-05
Bl 29».30. Up 2»6-2«1 C
TISSUE
2989
Blood,
cells
2990
Blood,
plasia
BIPOSUIE ROOTE
Ingestion
UlLTTICil
BITBOD
CC
CC
HOBBER
or CASES
al 8
b) 12
a) 8
b) 12
MIGB
•I 23-27 aaolea/dg
b) 22-23 o*olaa/4g
c) ». 5- 11 aaolea/dg
d) «-6.5 0*0 lea/4 g
•) 0.3-0.5 aaolaa/100 *1
b) 0.3-0.1 a*ole*/100 al
c) 6.2-16 aaol*»/100 al
d| 5.5-11.1 oaolea/100 •!
NEal
a) lot given
b| lot given
cl lot given
4) lot glren
a) lot given
b) lot given
c) lot given
d) lot given
GEIItIL IIFOBBlTIOg
a) Rang* of ••ana« 0 an4 B hi aftac
34 ag/kg to nocial subject*, aeacacad
«» aatabalit*, aipactat*
t) Bang* of Man a, 0 aid B he attar
31 ag/kg to phaDjlkatonurics,
aaaanr«4 a« aatabolit*, aapactat*
c| Banga of Man*, 0 and 8 he attar
3* ag/kg to nocaal aobjacta, a«uac«i)
ai Htabollta, phanrlalacina
d) Rang* of Mana, 0 and 8 he after
3* ag/kg to phanflkatoiiarlca,
a*a*ac*d aa avtabolita, phanyalanin*.
tatiaat*4 fcoa graph.
Idalti, 8 faaala hatarzrgotva tot
ph«nylk*tonacla, 6 noraal faaalaa, 6
necaal aal«a.
Data *ho> no d*tri**nt to PRO
honoxjgoa* fata* vith long-tar*
aatarnal 1«»«1« of < 10 ag/100 al (60
oaol«a/100 al).
IIIIO aCIDS; IDlas SBEITEIIIG ICTUS;
ICOLTS; B100D ?LISBa; BLOOD;
CCBPalaTIVE tmoatlOIS; DBDSS;
EITTBIOCTTES; BBTaBOLtSR;
BITaBOLITES; IBOROLOGIC
BlltrlSTITIOIS
a) Kang* of Man*, 0 and 8 hr after
3* agAg to noraal subject*, aaasurad
aa aetabollte, aspartate
t| Bang* of >ean*, 0 and 8 hr after
34 ag/kg to phenrlketoniric*,
a*a*or*d a* aetabolite, aapartat*
c) Rang* of **an*, 0 and 8 hr after
31 agAg to noraal •abject*, *ea**r*d
a* letabollte, phenylalanine
d) Range of Man*, 0 and 8 hr after
3« ag/kg to phenylketonoric*,
•*a*ar*d a* aetabollte,
phenylalanln*. Estlaated frca graph.
Idnlt*. 8 feaal* heterirgotea for
phaarlketonarla, 6 noraal faaale*, 6
noraal aalea.
eat* *ho* no detrlnnt to PKO
hoaot]rgoa* (etas «lth long-tar*
•eternal leiels of < 10 ag/100 al (60
aaoles/100 *1).
iBIlO tCIDSt I0la: SIBITBIIIC »OBITS;
IDOLTS; BLOOD FL1SBI; BLOOD I
COB?»RITI»E ETlLOaTIOIS; DRVCS;
IIITBROCITBS; HET1BOLISH;
BRIBOLITES: IEDROIOSIC
BllirESTlTIOIS
BBrEREICE
Steglnk, L.D.
Filer, L.J., Jr.
Baker, G.L.
RcDonnell, J.I.
Steglnk, L.O.
Filer, L.J., Jr.
Baker, G.L.
BcDonnell. J.E.
1979
00
00
-------
socclnlc «cld. aKcapto-, al«thyl »t», s-»t«c ultfc o.o-AlMthyl phnphonaithloat* (a ci)
BaUBCdlolc «old. <(dlMtkoxipko>pklnothiorl|tkio|-. dl«thrl •«t.r (9 cil
121-7S-S
C10-B19-O6-P-S2
» 330.36. I* 2.9 C. B? 156-57 C at 0.7 •• 19
IISSDI
2991
OrlM
2992
OrlM
INOSOBE BOOT!
lDj*ctlon
D«CI*1
.
aiUTTXCU.
BBTBOD
BadlOMtcj
GC
IUBBBI
or CISBS
$
10
H1GB
•1 lot gl«m
b) Bot given
««9-10T2 ng/il
ran
*| 90.2*
b) e.2X
635 ag/Bl
GBIEltL IBFOBBiTIOl 1
•I IT dOM of 1 OC1
b) topical »a«inl«tc«tlon of 1-5 «ci
P*cc*Btag* o( 4o»« •icc«t«d In 120
kE. Data In b) cocE«ct«d fot
lneoipl«t« C«COT»CJ based on data In
•I-
Bcalthf »olont««r».
*ISnCIDIS| II8BICIOBS:
OieilOPROSfBKES; CBMBXBB OBGIHC
COBPOOIDS; Ollit;
BHICH 1010CICWB IXIB8
10 of 1« wockcci itndled. Oth«r «
norkm ana 9 non-«zpOMd nock«E* bad
«nd«t«ctabl« I«v«li «20 pg/al) .
IiliMB for natabollta*.
loikvcs In piodactlon of putlcldi*
containing aalatklon.
Blood ckalln*«t*ra«« «ctlTltj
iDTtcMlr c«lat*d to vein* nalathlon
c««ida«« in 3 lockvn stadlcd.
VISTICIDB I1SIDQBS; TaGOSLKVUl
oiiiij otaiiopaaspBtnsi OCCOPMIOBIL
BlItBDS; COinBkTin BULOaTIOBS
BEFRBBICE
.
fvldnnnn, R.J.
Balbacb. B.I.
197«
Dn**nkar, T.
Frobi, z.
Ttoillc, Z.
Tkalccvic. B.
1979
00
-------
Sulfanllaaia., l(1)-(».6-dli«thrl-2-prclildlnTl)- (8 CI|
B«i«n**alfonaald*, *-aU.no-l-(«.«-dlMthrl-2-prcUldlarU- l» CH
C12-BU-H-OJ-S
II 278.32. If in c (alio npoetvd: 178-179 C, 198-199 c, 205-20'' C)
TTSSOE
2993
Blood.
plana
299»
Vein*
BXPOSOIE lOOTE
Ing««tloB
tagaatloa
IIU.TTICIL
BBTHOD
Colocliatr;
PliocoHtcr
ec
.....
Itm»BI
or OSBS
•1 i
b) 1
c| 1
•I «
b| 11
c) «
BIIOE
•) 100- •» gg/il
b) tOO- 16 «g/«l
c| 100-1 ag/*a
•1 lot glra
b) lot glvm
c) lot firm
nil
•) lot •ppUcibl*
bl lot ippllubl*
cl lot •ppllctbl*
t| 65.6% of «b«orb
tomt
b) 87.7* o( abiocb
don
c) 93. 7« of ibsorb
dot*
CIIEI1L IirOBH»TIO»
•) Slo« (cc 9*
bj lnt*CMdi*t< (Ic
c) ttmt (II graotjp*)
ttla«« ic« 0-8 he !•«•!•, and>«nq«d
Stag, tot «c«tyl«toc phvnatjf** »ft«c
20 «9/kg do««. IstiutM fen
graphs. 0«t« tlao glT*n foe
«c«trl«t«d i«t«bolit« tad kintlc* in
•11 19 «abj«cts.
19 hvtltkT tdalti «9«« 17-«6 jc,
(«»!•. •«!«, «hit«, oriental, bl«ck.
lo Mdlcitlon > 2* he b«foc« stodf.
Ta«t«d b«(oc« and aft«c doi*.
DIOOS; »ET»BOLISB; GEIETIC BfrBCTS;
B100D PLaSHIi aOOLTSi OIIIE;
CCBPlBJTIfB BTIlOaTIOISi BB»£OBEHB«T
amoos
a| Slow (cc gnotj;*)
t) Int«ci«diat« (Ic gvaotjp*)
c) Fast (II graotrp*)
?•!«•• ac« foe aotrlatod a«Uboli«»
is 72-he foe «c«tyl«tor pbinctjrpei.
19 k«alt>T adilt* ag«« 17-«6 ji,
(«•>!•, Ml*, »kit«, oriental, black.
lo abdication > 2* ke bcfoc* «tady.
lut«d OToenlgkt and foe 3 he afUr
don.
DIDfiSl BBTIBOUSB; OBIRIC BIFBCISj
B1000 FLISHlt 1001.13; OBIIB;
CORPilaTITB BVklOanOIS; BBiSOBBBBIT
aitaoDs
chapron, O.J.
Xeaiac, P.».
Rarlck. S.».
1980
chapron, D.J.
Kea»c, P.*.
Boclck, S.».
1980
VO
O
-------
Salfaallaaida. l(1)-(5-aathrl-3-l«oxa*olyl)- (B CI|
B*M««aalfoaaald«. *-aaiao-t-(5-a*thyl-3-l.aozazolyll- (9
723-C6-6
C10-B11-B-3-03-S
81 253.31. It 167 C
TI3SDB
2*95
Blood,
BXPOSOBE IOOIB
lagaatioa
tlatlTICU.
BCTBOD
-
BDBBIB
or CUBS
BMOB
31-189 «9/al
mi
lot appllcabla
OIIB1IL IHOtBkTXOB
ling* of na» 2 hi »ft«r QOM. day 1
tad 9. IIS ag/il an d«y 12, «nd of
tttal. Do»«, 20 agAg/day at
tcU«tkopcli Kith 100 i9/k9/far
*alteMtkoi«xol« at (-he lnt«r»al«.
Battaatad fro* graph, laabat of
caau racial daily ftoa 5-20
dapaadlag on nipou* to thatapy.
Childran «ltb pnaiaocyatia cactnil
paaaaoaltia. neaivlag
itaaaoampptanl*a tkacapy fot
•tliqaaacy. Soaa on antlbloUca.
toaltlag or actlcaclal caah IB *
patlant*.
OB OSS; DIOO tHBUPt; IIFECTICB;
CBIIDBBI; BBOPliSSS; TB1BBSSIJ; BLOOD
SB10I; C0171B4TITI BTILOITIOBS
1BFBBEICB
Baghaa. I.X.
Faldaav. S.
Chaadhacy, S.C.
Oaal, B.J.
Cox. t.
Saayal, S.K.
\O
-------
Salfanllaalde, I (1)-2-pyridyl- (8 CI)
Banieneeulfontalde, a-anlno-l-2-pTTHinyl- (9 CD
1W-83-2
C11-B11-B3-02-S
81 2«9.29, HP 191-193 C
TISSUE
2996
Blood.
plant
2«97
Blood,
plasaa
2998
Orlne
EXP030BE lOOTE
Inge at ion
Ingest ion
Ingest ion
l»LTTICaL
8ETROD
Colorieetry
Colorieetry
10HBB*
OP CIS 85
«
5
6
EklGE
•) 6.26-18.6 ug/el
b) a. 15-9. 3» 19/1!
a) lot applicable
b) lot applicable
c) 15-85 ug/el
...
50.3-67.9% of do**
HBal
a) 13.3 » or - 2.6
ag/al
b) 6.8D » or - 1.1
»g/al
a) 68 99/11
b) 58 tig/si
c) (2.8 09/1!
60. 8S ot doi«
GEIIItl IlrOBKITIOl
a) p*ak, 2 9 >alfa>alailn« ID
ancoatad ttblata. p«ak tla« U he
t) Peak, 2 9 snlfaMlazln* ID
•ntaclc-coatad tablet*. Peat at 19.5
hr
EloaTallablllty of drag froa
eaterle-coated 66V of ancoat«d.
• healthy aalu, agea 21-31.
DIOOS: DBOG THEB1PT; AOOlTSi IEI
IOIK; C08P»B»IITE EULDUIOIS; BIOOD
PLkSBI; OlSIBOIIIESTIHt SISTER;
BIHBOIITES
a| Peak at 12 he after doae, before
aergical reao
-------
*. •{1)-2-pTCi.iaiHTl- (8 CI)
66-35-9
C10-»10-ia-OZ-S
Bl 250.28, BP 252-256 C
TISSUE
2999
Blood.
plassa
BIPOSOIB IOOTB
IngortloB
-
lIURXCtL
HBTBOD
IDBBB1
OP CaSBS
•I 16
b) 16
e| 8
ai a
•> a
(I a
UIQB
•1 0.9-19.3 «,g/Bl
b) 0.9-16.2 ag/Bl
e) 1.«-17. 7 ag/ml
d) 1.3-17.* ag/«l
•) 1.3-19.0 gg/il
f) 1.3-18.9 ag/«l
Hill
-,,-, ^
•1 lot glfn
b) lot gl»B
e) lot ginn
1) lot glm
•1 lot glvin
f) lot gif«n
GBIIBIL uroiiatioi
•) Orel lolgtion
b) Sa>p«n«loD |B11 lllly)
e) T«bl«t« (111 Llllr)
4) Tablets (Iidecll)
•) TabUts (Staolabi)
() TabUts (BichlTd)
Oe*»», 500 eg. Maks at 2.9-i.S he.
lo dlfCccancu in bloa»llabllltr.
locul (dalts (20-30 jl old.
66.8-93.2 kg).
DiOSSj CORPIUTIfE BUlOiTIOIS:
1ITIBIOTICS; BLOOD Fl»SH»
IEFIBBBCB
I*T«E, B.C.
Stnaghn. 1.6.
I»achand«r, a.
Caragnol, J.c.
Habadaj*. l.r.B.
1978
NO
CO
-------
silfar
Itl 32.06*. HP 115.21 C, BP «bo«t Ml. 6 c
TISSOE
3000
Ull
BIPOSOSB BOOTS
II1LTTICIL
DRIOD
It
I088B8
or CISBS
•1 50
b| SO
C) 31
1) 23
IIIGB
•1 lot giT«D
b) lot 9lv«n
c) lot glvrn
d) lot 9lT«n
nli
•I 3.6%
b) 3.9*
c) 3.5*
4) 3.9*
GBIIB1L IBTOBRATXOII
•1 Fath«r»
b| Bother*
C) HftL* tMDA9»n tg* of
(•thir<, «6 yr, lothic*. »1 jt. *3
••!• cklldr«n. 12-2* yc and 38 t«ial«
cblldnn. 12-2* yc.
CILCI08; SODIOB; RtQI8SID8; U OKI 108:
sotroi; C8LOIHS: TIHIIIOB:
allGtIESE: COPPEIi IB1CB ZLiniTS;
(ICOD PBBSSOIE; 181 OOIIBJ; C8TU.S;
ItlU
IBFBBEBCB
HailcoDl, B.
Koirtyohano, s.l.
PUrra, 3.0.
Schauchala, P.C.
1976
VO
-------
301 Carle «cid »90««ia> ««lt (1:1)
•3113-11-9
C10-B8-12-02-S2.H2-0»-S.89
If 37«
coapd. «ltk
TISSDB
3001
Blood,
pluia
3002
Ocln»
EIFOSOIE tOOTB
Inject loo
,
Injection
D*CMl
IIUTTIC1L
BETBOD
ladlOMtry
IOHBBI
Or CiSBS
«-6
5-6
11IGE
a) lot gi*«n
b) lot giT«n
c) lot gl»«n
4) lot gi»«a
•) lot gltm
f) lot glran
•) tot glvn
b) lot ginn
c) lot glnn
d) lot gl»<*
•I lot given
f) lot glt«n
ntl
a) « ag/mi
b) 0.05 ng/il
c) 0.01 ng/nl
4) 0.003 ig/il
•) 0.01 ng/nl
ft 0
•) 59.3*
b) 3.2*
e) 11.2*
d) 15.3*
•1 6.2*
fl 13.2*
GEIHIL IIFOailTIOl
•1 15 Bin
b) » he
e) 2* he
1) «e hr
•) 96 he
tl 120 he
tcoCll* bu*d on change In
ridlotctlTlti at tiM« after a c-1»
labelled 1 ucl d«« of aagaaalua
•ilftt* addict of th« drag.
DIOOS; BLOOD PLISM; OIIIB
a) Intca»«noia injection
b) Topical adilnlitcatlon (Tcotcal
Centra) of 12 ag/«2
cl Topical administration (forahMd)
of 12 ag/cn2
d| Topical addnlstration (forctaad)
of U «g/cn2
•1 Topical adnlnlatratlon (•ealpl of
12 ag/c*2
ft Topical adalnttratlon («calp) of
•0 U9/CB2
(•roaatag* of doi* «icr«t*d In 120
hr.
DIBOS; BLOOD ?t»SB»; OIIII
1BFEIBICE
ladlg, J.B.
Paldunn, B.J.
Ralbach. B.I.
1977
••dig, J.B.
Foldaann. B.J.
Balbach. B.I.
197T
VO
01
-------
t
GBiiitL iiroiainoi
-
•) P*«k 7 he «(t«r •dilnlitEition
b) «8 he aftar •lilnlatratlon
(•lightly abon backqroand)
1.9 z 10(B»10) cpi (or 20 iCi)
inj«ct*d. Sp«ciClc acUTitr not
glnn. Data a*ailabl« (or
lotacnaiat* tlM Fointa.
29 yr old lactating aothar. ^ ok
poatpactgi.
IICTITXOB! BItK: HnlLS; TECEIBTIOB;
HOIOISOTOFBSt °HIO
BEFIBBICB
Pittacd, «.§.
Bill. X.
flatehw, B.O.
1979
VO
-------
Tballiaa
7MO-2B-0
It! 20«.37, If 303.5 C. Bt 1»S7 C, TP 1 •• Rg at 825 C, 10 •• Bg »t 1000 C
TISSUE
300*
IdipOM
3005
Idreaal
gland
3006
lorta
3007
Bladder
3008
Blood
EIPOSOBE nan
1RUYTIC1L
IBNOD
as
RS
as
RS
BOBBBB
or CISBS
1
2
1
1
UIQB
lot applicable
(IIZT
Hal
•0 ug/1
PIOB)
GEBIBIL IEF01HITIOB
Igad 73 jr. Be*ie«.
TBIlLiaR; BBTILS; STOBICH; PBOSTtTE;
1ISTBS; OTBBOS; OT1BIBS; LTHIB BOOBS;
SILITlET GLIIDS; TBHOIO QUIDS:
IDBBRIL GLIBDS: PIBCBBtS; PTIBU
UtBD) PIIOIUBt QUID: IOBT1;
BltDDBBl Ottt BllDEBBi OOHS;
CIBTILtSE; TBIDOBS; UGMBBTSl BOIES:
3IIB; BUB; BlILSl IBTBSTIBBS; LOBOS;
BOSCIBS; SPIBBI; BBkBli BB1IB;
IIDBBTS: OBIBI; TBITB: LXTBB: BLOOD;
BIOOD SBB0B; IDIPOSB TI3SOE; BBTIBI;
IOTOPSIBS
F<»1< aged 73 Ji, and aala <9«d IS
Jt. B«Ti««.
TBaLLIOB; BBIUSS STOB1CR; PFOSIITB;
TISTBS; OTBBOS; OTIBIBS; ITBfH BODES;
SILIT1BT QL1BDS; TBTBOID OLIIDS;
tBISBtt OllBDS: P1BCBBIS; PIBB1L
CllBD; PItOITUT OllBO: lOITIi
BltDDBB; Gill BlkDDBB; OOHS;
CIBTILtSI; TIBDOBS; IIOIHBBTJ; 80BBS;
SUB; BUB; BIIL3; IBTBSTIBBS; LOBOS;
BOSCLES; SPLBBB; HUBT; BBIII;
BIOIBTS; OBIBB; TBITB; LITEB: BLOOD;
BIOOD SEBOH; UIPOSB TISSOB; BETIBI;
IOTOPSIBS
>9«d 73 yr. B»»iB«.
TBIUIOB; RBTaLS; STOHICB; PFOSTITB;
TBSTBS; OTBBOS; OTUIBS; ITBtB BOOBS;
SILITUT GLIBDS; TBTBOID OUBDS:
ICBN1L GLIBDS; PIBCBBIS; PIBBU
CLtBD; PITOITUT OUBD; IOBTI;
eilDDEB; GILL BUBDBB; GOBS;
CIBTIHOI; TIBDOBS; LXGUBBTS; BOBBS;
S»B; HUB; BULS; I«T5STIB8£: LOBGS;
HOSCLBS; SPLIBB; HBIBT; BBIIB;
KIDBSTS; OBIBB; TE1TB; IITBB; BLOOD;
BIOOD SEBOH; IDIPOSB TtSSOB; BBTIE1;
tOTOPSIBS
P«ial* ag«d 73 jr. and aal« «g«a 16
yr. I«Ti««.
TBH.LI01; BBTtLS; STOBICH; PBOSTITB:
TISIES; OTEBOS; OTIBIBS; LTBIB BODES;
SILITIBI GLtBDS; TBTBOID Gil IDS;
• DBEBIt OllBDS; PUCBEaS; FIBEkl
CXtBD; PITOITWT GX1BD; IOBTI;
BliODEB; GILL BtlOCBB; GOBS;
C1BTILIGE; TIBDOBS; lIQIHBBTi; BOBBS;
SBIB; Hill; BIILS; IBTESTIBES; LOBOS;
•OSCLES; SPLESB; REIBT; BBIXB;
KIDBETS; OBIBB; TBITB; LITEB; BLOOD;
BIOOD SBBOR; IDIPOSE TISSOI; BBTIEV;
IOTOPSIES
2.5 yr old. ocin* paak 3900 og/1.
Bo neurological ayiptoaa. Hair (ell
oit.
TEILLIOH; OBIIE; BIOOD; CRILCBBB;
GKIHT; RITILS; BETtL PO I SOU 10
BEPBRBBCE
Carson. B.L.
Saith, I.e.
1977
Carson. B.L.
Salth, I.e.
1977
Caraon, B.L.
Saith, I.e.
1977
Carson. B.L.
ssith, i.e.
1977
Ton laahlendahl. K.E.
Etzold, R.
Kcianka, E.G.
1978
SO
-------
ThallUa
ioo-js-0
Tl
Itl 201.37, IF 303.5 C. n 1*57 C, ?P 1 an 19 at 825 C. 10 •• Ig at 1000 C
(COETIIOSD)
TISSOB
3009
Hood
3010
BOI«
3011
Brain
3012
cartilag*
IIPO30BB 100TB
_ ,
1BILTTICII
nnoo
ll*CtrOch«
us
as
US
»S
SS
IOBBBS
or cis is
s
s
2
laBoi
(•BIT
mi
PICE)
GIIEI1L IBrOBBlTXOE
Blood and blood ••»•. Juf«nll«s and
idalta. locul and poisoning casas.
!•*!•«.
TBlLLIOa; BBTiLS; STOR1CB; PFOSTaTE;
TESTBS; OTBIOS; OTIHBSj LTBtB IODBS;
SILITIIT OtlBDS; TBYBOID OilIDS!
IDBEEIL OlIBDS; PIICBBlSi HIBU
8l»ID; PITOITUT OUBDi 101TII
BltDOBI: Sail BL1DDII; OOBS;
CISTIHGIi TCIOOIS; tlOIBBBT!; BOBBS;
Sill; IHIi! BUlSi IBTBSTIBBS; UIBOS;
BOSC1BS; SPLBBBi RBIIT; BB4IB;
KIDBBIS; OBIRB; TBEIB; tITBB; BLOOD;
BIOOD SBSOB; IDIPOSB TISSOB; BBflBI;
IOTOPSIIS
Bits, cranial roof, thigh coipaeta.
lorul aad pelaoBlng can«.
TBiUIOB; BBULS; StOIHCB: PWStME;
TIStBS; OTBBOS; OTIBIB3; LTBfB BOOBS;
SILITMT OLtBDS; TBTBOID OLIIOS;
IBBBBIl 3LIBDS; PIBCBBaS; PIBBaL
CUBDi PIIOIUBI 011BD; aOBTI;
BI100BB; 0111 BLaDDBB; ODBS;
CIBTIlial; TIBDOBS; LI01REBTS| BOBBS;
SBII; BUB; IHIS; IBTBSTtBBS; I.OIGS;
S03C1BS; SPLBBB; HE1BT; BB1II;
BIOBBIS; OBIBC; TBRB; LITBB ; BWOD;
BIOOD SBBDB; aDIPOSE TISSOB; BBTIBI;
10TOPSTES
c«c«b«llH, aodalla
otlongata, corpus itdttai, chotold
(laias, o«cl«o« cat«c, aaclca aigmr,
Internal capial*. locaal aad
[olaonlng ca«u. B«T!*«.
TBtltlOB.; BBTILS; STORaCB; PtOSTkTE;
tISTBS; OTBBOS: OTaBIBS: ITBtB BODES;
SHIflST OlIBDS; TBTBOID OtllDS;
ICBBBKl OlIBDS; PIBCBBIS; PUEU.
GlaBD; PITOITUT GIllDl 10BTI;
BItODBB; Sill BlaDDBB: GOBS;
ClBTXtlOB: TEBDOBS; UG1REIT!; BOBBS:
SBIB; Bill; I1ILS; IBTBSTIBESl WIGS;
BOSCtES; SPLBBB; BE1BT; BBalB;
KIDBETS; OB IBB; THIS; LITEB; BIOOD;
BLOOD SEBOB; aDIPOSE TXSSOE; BBTIBf;
10TOPSIES
epiglottis, i»niaco«. and lit
eactilag*. r«aal« ag«d 73 jc, and
•al« agad 16 rr. B«»l««.
TBILLIOB; BBTUS; STOBICB; PKSTaTE;
TtSIBS; OTBBOS; OfUIBS; LTBIH (ODES;
SILITIIT OLIBDS; TBTBOID OLaBDS;
ICBEEaL OlalDS: PUCIIaS; PIIBU
CHID; PITOXTaBT OHIO: IOBTI;
ELIDDBB; Oltt BLaODBB: OOBS;
CIBTILIOB; TCBDOBS; UOaBEBT!; BOIES;
SBIB; Ball; IlltS; IBTSSTXEES: LOBGS;
BOSCLES: SPLEBB; BEIBT; BBIXB;
BIDBETS; 01IIE; TBRB: LXTBB; BLOOD;
BLOOD SEBOB; IDIPOSB TISSOB; PBTIBI;
IOTOPSXES
BEFEBEICB
Canon, B.L.
Silth, I.e.
1977
Carson, B.L.
Silti, I.e.
1977
VO
00
Canon, B.L.
Snlth, I.e.
H77
Carson, B.L.
Saltn, I.e.
1977
-------
IkllllM
7MD-2B-0
It! 20*.J7, If 303.5 C, BP 1*57 C. T» 1 II l« at 825 C, 10 II Bg It 1000 C
(COITI10IO)
TISSOE
3013
Mil
UcdteE
301*
Ou
3015
lUlr
3016
B«*rt
IZfOSOU IOOTI
1BURXCU.
M1HOD
IS
U
OS
ColorllitCT
IS
EOBBSI
OF CIS S3
2
2
16
1
•1MB
,
(HIT
•Ml
.,
*
P1GB)
GEiEEiL iBFOBBinoB
-
I«i*l« •]•! 73 yt, and ul« *g«d 16
jr. ••*!••.
TBIUXBR; 8BTt LS) STOB1CB: PtOStlTEj
TISTBS) OTBBOS; OTlltlS; ITBfB BOBBS;
SUITUT GLIIDS) TBtlOXD OllBOS;
IDIZIU. OLUDS; PIKIB1S; PIBBtL
«MBOI rxioxtUT OI»»D: toiti:
BUODBl; etll BLIDOBB; OOBS;
CIITILIQI: TIIDOIS; UaiBBBTSi BOBBS;
SlIIl BIXBi BULS; XRBSTXBBSi LOBOSi
BISCLBS; SPLBEB; BBtlt; BBIII:
IIOBBTS; OBIBB; TBttB; LXTBI; BtOOD;
BMOD SBBOB; tDIPOSB TXSSOB; IBUBI;
IOTOPSXBS
-
f«itl« «9«d 73 jr. ni ul« «9«4 16
jr. I«l«i.
TBttUBB; BBTUS] STORICB; PBOSMTB:
TMIBS; DTBBOS: OT1IIBS; LTBfB BODBS;
SUItllT 8I.IBD5: TBHOXD «LtlDS;
IDiniL aUBDS; PIBCUtS; PIBB11
CltlD; PITOXtlBT atlBDj 10BTI:
BIIDDBB; 8111 BL1DCB*: 6DBS|
CIBTXliail TBBDOBS: U01BBBIS; BOBBS:
SUl! B1IB; B1XLS; iniSTIll;; LOBCS;
BOSCLBSl SPLEBB; RB1IT; 1*1X11
IIDIEIS; OBXBB; TBRB; tXTBB: BLOOD;
BtOOO SEIOB: 1DIPOSB TXSSOBi BBTXBI;
1 HOPS IBS
I««il«
TB1LLIOB; BET11S; STOB1CB; PUST1TB;
KSTBS; OTBBOS) OT1BXBS: LTBtB BOOBS;
SILIT1IT QUIDS; TBTMID 6L1B05;
IDBBB1L OllBOS; PIBCIB1S; PKBll
BtlBD; PITOIT1BT 011(0; 10BTII
BL1DDBB; 0111 BL1DDBI; ODBSJ
CIBTX1IOI; TIIDOIS i IXOIBBBTS; BOBBS;
SIXB; Bill; BlILS; IBTBSTIBBS; L0BGS;
BOSCLBS; SPIBBR; BEIW; BBlIli
IIDIETS; OBIBB; TKIT8; LITBB; BLOOD;
BtOOD SB10R: IDXPOSB TXSSOBi SBflEI;
IVTOPSIES
SOicldl. >•
-------
Thalllu
7MO-28-0
Tl
Itt 20«.37. IP 303.5 C. BP 1«7 c. TP 1 » Hcj «t 625 C. 10 >• 19 at 1000 C
(COETIEOBD)
(KIT PlOB)
TissoB
3017
Int«*tln*
301*
ua»r
3019
Llg«»at
3020
Liter
EXfOSmB BOOTB
IRILTTICIL
RETROD
RS
RS
RS
IIS
RS
IORBRI
or CISBS
8
1
,
20
ItMl
RSII
GEIIBIL IIFOftRITIOE
Diodmai, mil int«>tia«, cclon,
octal. Be»l««.
TBILLIDH; HETILS; STOHICB; PtOSTITE;
TBSTBS; DTBIOS; OTUIBS; LTRFB BODBS;
SILITIBY OLIBDS; TBTBOID OH IDS;
IBBEIIL OLIEBS; PIIC1B1S; PIIBIL
CltlD; PIIOITIBI OHIO; »Oltl;
eilDDBB; 8111 BL1DDEB; GOHS|
C1ITIL1GI; I IIXII3; LieiBBBTS; BOIES;
SHIR; HUB; BULS; IBTBSTZBE!; LOBOS;
BOSCLES; SPLCBB: BUST; BBIIB;
(IDBEIS; OBIBB) TBBIH; UTBB; BIOOD;
BIOOD SBIOH; UIPOSE TISSOEl BBnBB;
10IOPSIBS
B«4all« «B4 cortvx. Bocial nd
poiioilng c*i». B««l«*.
TBtlLIOfl; BETtLS; S10R1CB: PSOSTHE;
TISfESi OTEBOSl OTMXBS; LTIIB BODES;
SILITIBT OH1DS; TBTBOID GLADS;
IBBEEIL OH IDS; PIICIEtS; PIIBIL
CUEDl PITOITIBT OHIO; 1OBTI;
BItDDER; GILL BL1DDBK; GORS;
CI1TIL19I; TBBDOBS; LldtRBETS; BOIBS;
SBXB; HUB; I1IL3; IBTESTIBBS; LOBGS;
HOSCLBS; SPLBEB; HB1BT; BBIIBi
RIDBETSt OBXBE; TSHHl LXTEB; BLOOD:
BIOOD SEBOB: IDXMSB TXSSOSi BETXEI;
lOtOPSIBS
ligsiintQi nachii. lg«4 73 jr.
l«»i«»
IBHtlOH; HET1LS; STOIUCH; PIOSTtTE:
TISTBS; OTBBOS; OT1BIES; LTBFB BODES;
SILITtBT OLIIDS; TBTBOID OH IDS;
IDBEBtL OLIBDS; PHCBEIS; PIBEIL
CHID; PITOXTIBT OLIBD; IOBTI:
tllODBB; GILL BLIODEB; GOBS:
CIBTILIGIt TIBDOBS; LIOIHBITS; BOIES:
SUB; BUS; BIILS; IITBSTIIBS; LOBOS;
BOSCLBS; SPLBBB; RZIBT: BBIXI;
KDBETS; OBXBB: TERR; LITBB; BLOOD;
BLOOD SBBOBi IDIPOSB TISSUE; BETIBB;
IOTOPSXES
Boiul *i4 poisoning C«M*. B«T!<>.
TBILLIDH; REIILS; STOIUCH; PMSTkTE;
TESTBS; OTEBOSl OTIBIES; LTBtB BODBS;
SILITtBT GLIBDS: TRTBOXD OHIDS:
IDBBBIL OH IDS; PIICBBIS; PIIBIL
CLIBDi PXfOXTIBT OLIBO; IOBTH
BLIDDBB; GILL BLIDDBB; GOBS;
CMTILIOB; TEBDOBS; LIQ1BBBTS; BOIBS;
SUB; RUB; BIXLS; IRSSTIBE!: LOBGS;
BOSCLBSt SPLBEI; HBltT; BBIII;
(ID1EIS; OBIIB; TE1TB; LI?EB: BLOOD;
BLOOD SEBOHI IDIPOSB TXSSOE; BBflEI;
IOTOPSIBS
BBrEREBCE
Canon, B.L.
Snlth, I.e.
H77
C«cw>n. B.L.
Slith, I.e.
1977
Ckrsoa, B.L.
S*lth, X.C.
1977
Ckcion, B.L.
Slith, X.C.
1977
o
o
-------
Tialllai
1MO-28-0
II
>tf 204.37. at 303.5 C, BP 1«S7 C. TP 1 •• lg «t 825 C. 10 •• B« «t 1000 C
(conxniD)
TISSDB
3021
L»g
3022
IT»P»
nod*
3023
Duel*
30 2»
•ail
iiposmi IOOTI
aULTTXCtl
BBTROD
IS
15
as
BS
BOBBBB
or CISBS
B
2
a
15
UNB
-
(HIT
BB1B
PlOB)
GBIBBIL IBPOBBHIOB
t*
laiLiioa; BBfusi sroaicB; PBSTITB;
TISTBSl OTBBOS; OVIIXIS; LYgPg lOOBSl
3UIT1IT fllUDS; TBTIOID SUDS;
UlBltL QL1IDS; PlICBBlSj PXIBIL
siHD; PITOITMT aunt »o«ti;
IliDDBl; Sill BLtDCBB; ODHSJ
CIHIliaB; TBIDOBS; UOUIBTSj BOBBS;
Sill; Bill; Hits; IBTBSTIBBS; WIGS;
BDSCIBS; SPIBBI; BBMTi BMIB;
IIDIBTS; 01III; TBITB; 1ITBB; BLOOD;
BIOOD SBBOI; UIPOSB TXSSOBi BBTX11;
lOTOfSIBS
f»ll« «a«a 73 re, «B4 Ml* »g«a 16
JI. l«*l*«.
THUIORl BBTtLSi STOBkCBj PIOSMTB;
TISTBS; OTBIOSi OTI1IB3; LTBtB BODIS;
SUXTUI BLIBDS; TBTIOID GL1BDS;
IDBBBU OLIIDS: PUCBItS; PXBBI1
CItID; PXTOItUT OtiBO; 10BTI;
BIIDDB1; 6*11 111DDBB; OOBS;
CIITIHOE; TEIDOI5; lIStBBITS; BOIBS;
S(IBt Bill; MILS; HTBSTHB3; IOIOS;
BOSCtBS; 3PIBBB; RBkBTi BUII;
BIDRTS; OIXBB; TI1TB: LITBl; BLOOD:
BIOOD SIIOB; tDIPOSB TISSOI; BBnBI;
IOTOPSIBS
Sk«l«ttl and h«»tt >a«cl*i.
ttcio-Tcntclealkr nod*. !•*!••.
TBIUIIB; BIMLS; STOBICH; PIOSUTB;
IISTBS; OTIBOS; OT1KIS) LtBfH MDBS;
SUITUT eitBDS; TBTIOID QUIDS:
IDlnil Oil IDS; PIBCIBK; PIBBtt
CHID; PXTOXTIBT QUID; AOBTI;
B11DDBI; GILL BLtDBEti GOBS;
CI1TILIQE; TEIDOI3: LXOMBITS; BOIBS;
SKII; HUB; HI IS; IBTBSTIBB9; LDBSS;
BOSCtBS; SPLIBI; BBJiT; BB1II;
tXDIBIS; UIIIE; TBITB; LXTBBt BLOOD;
BIOOD SIIDB: 1DIPOSB TISSOI; SBTIES;
IOTOPSIBS
linger- and to«Daila. B*>1*«.
TBtLLIOH; BBTalS; STOBaCB; PtOSTHTB;
ItSTBS; OTIIOS; OTIBXIS; LTR(B IODBS;
SIlITilT OLIBDS; TBTIOID OLIIDS:
IE1BI1L 0 11 IDS; PtIClBtS; PIRBU.
GIHD; PIfOITkIT QUID; IOBTI;
BUDDIB; Oil! BLIDOBB; OOBS;
CIBTIH01; TtlBOIS; LI01BBITJ; BOIBS;
SUB; Bill; IIIIS; IfTSSTIBIS: LOBGS;
BOSCLISj SPLBBI; BBtBT; Blall;
KIDIITS; DRUB; TEETB: IXTBI; BLOOD;
BIOOD SBIOB; JDIPOSE TISSUE; RBTIBI;
» BIOPSIES
BBTBIBICB
Carson, B.L.
Siltk, X.C.
1977
Orson, B.L.
Siltk, I.e.
1977
Cac«on, B.L.
Snith. I.e.
1977
Carson, B.L.
Snlth, I.e.
1917
-------
ThlUU*
1MO-J8-0
tl
Itl 20«.37. IP 303.5 c. BP US'" C, TP 1 •• a« it 925 c. 10 mm Sg at 1000 C
(COITHOBO)
TISSOB
3025
0»«»
3026
P«ncr«>*
30 27
Plm*l
glMd
.
3028
Pltmlttrr
BIPOSOBB BOOTB
iiiimcit
BETROD
BS
IS
as
as
BOHBBB
or CMBS
i
2
1
2
mac
(BBIT
mi
pion
GIICBIL IIPOBB1TIOI
>g«d 73 yc. !•>!••.
IBILLI01; BET1LS; STOBICB; PIOSTITE;
TISTBS; OTBBOS; OTUIBSj LIBfH IOOBS;
SltlTIBT OllBDS; TBTBOID OLIIOS;
tClBIAl Ot»IDS: PIICBBIS; PIIBtL
SlllD: PITOI11BT OHIO: 10BTI;
BliODBB; 01 II BL1DDBB; GOBS;
ClitlllOI; TIIOOISs IIH»BBITS; BOIES;
Sill; BtlB; B1I1S; IBTBSTIBBS; UJIOS;
IOSCLBS; SPtBBI; HURT; BBtll;
IIDIEIS; 01111; TBRBi LITBB; BLOOD;
HOOD SIBOH; tDIPOSB TISSOBj BEflBI;
10TOPSIBS
P<»1« «9«d 13 jt, in a •»!• §q«a 16
;c. l»in.
TIllLIOB; SITUS; STOMICB; PIOSnTB;
TIStBS; OTBBOSi OTUIBS; HBtH BODBS;
SUIT II I GLIIDS: TBnOID OLktDS;
ICiniL 0 LI IDS I PIICII1S; PIBBkl.
CltlDl PXTOIT1BT OHIO; iOltl;
BllOOBB; GILL BLIDCEI; GOBS;
CllIIllOB; IBBDOBS: IIOMBBT!; BOIES;
SHI; BUB; IIILS; IBTBSTIOS; LOIGS:
BOSCLBS; SPLBEIl BEIBT; BBUI:
BIDIBTS; OBIBB; TBET8; LITBB: BLOOD;
BIOOD SEiOB: 1DIPOSB TISSOB: BBTIBB;
IBTOPSIBS
lg«A 16 jr. l«Tl«>.
IBILLWB; RBULSl STOBlCBi PWSIIIB;
TISTBS; OTBBOSi OTtBIBS; LIBIB IODBS:
JILITIBT ailOS; TBIMID OH IDS;
IDIBI1L SLIIDS; PIICII1S; PUSH
CLIID; PXTOITUI BUBO; IOH 1;
BLIDDBI; Gill BLIDDBI; OOHS]
CIITILIGI; tBIDOIS; LIOIBBBT!; BOIBS;
SHI; SHI; BULSl IBTBSTIBBS; WIGS;
BOSCLBSj SPLBBB; IB1BT) BBIII;
BIDBBTS; OBIBBl TBKB| LITBB; BLOOD;
BLOOD SBIOB; IDIPOSS TISSOB: BETIBI;
10TOPSIBS
!«••!• ag«d 13 yr, «n4 ul« igcS 16
TE. B»»l«».
TBtLLIOH; BETILS; STOBICB; PBDSTtTBi
TISTBS; OTBBOSI OTUIBS; LIBPB BODBS;
SILITIIT 8LIIDS; TBTBOID Oil IDS;
IOBBBU Ol»IDS; PIICIBIS; PIIBll
CHID; PITOITUT BL1ID; IOITI;
BltDDBB; BILL BL1DDBB; OtJBS;
CIITILlai; TIBDOBSs LIOIBBITS; BOIES;
SHI; B1IB; IIILS; IBTBSTIBBS: WIGS;
BOSCLBS; SPLBBI; BUIT; BBIII;
HDBBTS; OBIBB) TBRBt LITBB; BLOOD;
BLOOD SBBOB; IDIPOSB TISSOBl BBTIBB;
IOTOPSIES
BBPBBBBCE
ClCCOn, B.I.
Sltth, I.C.
1917
Cacnn, B.L.
Slitk, I.C.
19T7
C*r«on. B.L.
Slltk, I.C.
19T7
CtrcoB. B.L.
SBlth. I.C.
19T?
-------
1MO-2B-0
It! 20».37, >P 303.5 C, IP 1«S7 C, TP 1 •• «9 «t 825 C, 10 •• If «t 1000 C
(CORIIOIO)
nssvi
3024
rco*t«t«
3010
StllvtCT
gl«BA
3031
skli
3032
SplMD
iiposon MOTS
1MLTTICIL
•BTIOD
IS
IS
IS
•oiin
or cisBS
i
2
*
itiei
.
(KBIT
mi
PkGE)
ailllll IITOBBHXOI
19*4 16 JI. I«Tl*l.
TU11IOI; IITUSi STOBlCHj PMST1TB;
nsnsi trends ; OYMIBS; LTIIB MOBS;
31LITI1I UIIDSt TBIIOID QUIDS;
innii aunsi ruciits; PHBU
CtllOi PXTOITUT OHIO; 10MI;
IMDDlll 8111 BLlDCni OTIS)
cittxitai! iinoisi uaiimsi BOIBS;
suit mii MILS! imsTins; traas;
•osnisi sriBni IUITI BIIIH
HDIITSi mill; TBtTH; 1I»B1; BLOOD;
HOOD sciai; IDIKSI Tissai: tirni;
imOFSIBS
ruotld gl»d. r«ul« «g*4 73 ji,
mi »!• I9«d 16 ji. !»!•«.
IHUIOIs BlfttSi STOfliCI; FIOSTtTl;
tistis; OTHOSi ovunst it an IODBSI
SILITIlt OLtBDS; flllOID OLklDSt
ICintL OL1IDS; PIICtBISi tlllll
81110; PITDITUT aillDl 101TIJ
HtDDHi 8111 BLiODBII GOBS!
CIITILteil TIIDOIS: liatlBITS; BOIBS;
SRXIl BUI) BUlSl IRIStllBS; lOIOS;
BDSCLBSt SPliai lUITt BB1II;
(IDIBIS; Ollit! TBRI; LITMj BLOOD:
BIOOD SBIOI; UIPOSB TXSSOBi BBT1BI;
IOTOPSIIS
!•«!•«
TI1UXOI; IBIttS; STOBICB; PIOSUTIi
TISTBSI OIBIOSi OTUXIS; LTIIB KDBSi
siuvm eniDS; TBIBOID otiios;
IDintl. QUIDS; PMCIIlSi PHIIl
HUD; PXTOXTUI 8U1B; »OBII;
IL10DBB) Oklt BUDDn; OOIS:
ClIKliai; IHDOIS; ttOlBMTS; BOIBS;
SIXIt Milt IUISI XITBSTXIB!; L01QS;
• OSCLBS; SPLBH; BB1OT; BB1II;
KIDIEIS; 01X11; TBRI; IXTBIS BLOOD;
BIOOD SBIOI; IDIPOSB TXSSOB; «B»IBI;
IOTOPSXBS
lorul tnd pclioDiog CIHI. B«*i«*.
TKLLIOI; BBItlS; StOBiCH; piOSMTI;
TtSIBS; OTIlOSt OTIIIBS; LTBtB IODIS;
SILITUT SLI1DS; TBTBOID QLIIOS;
iciniL atiios; piiciiksi PIIBIL
OIHD; PXTOXTUT QUID; »01TI;
B11DDB1; GUI BlkDDBB; OOISS
C»ItIHQI; TIIDOIS: IIOIBBBI3; BOIBS;
SRXI; Mil; IIIISs XITSSTXIBS; LOI6S;
BOSCLBS; SPLIBI; BB1ST; BBUI;
RIDIBTS; OIIIB; TBBTI; LITEB; BtOOD;
BIOOD SBIOI: IDIPOSB TISSOS; IETIBI;
IOTOPSIBS
IBPBIBICB
C«r«on. B.t.
Slith. I.e.
1S77
C«C«OB. B.I.
Sllth, X.C.
1977
Cirion. B.I.
S.ltk, i.e.
1977
Cacaan, B.L.
Silth, i.e.
1977
o
U)
-------
Taalllaa
1MO-J8-0
Tl
Itl 20».37, IP 103.5 C. IP 1«5T c, V? 1 •• Eg at 825 C, 10 •• Rg «t 1000 C
(CORINBD)
TISSOE
3033
Stoaaca
303*
TMta
3035
TandOB
3036
Taatia
EIP030RB IOOTI
1I1LRIC1L
BRIOD
83
IS
RS
US
EOBBBB
OP CISBS
2
2
1
IIME
|IBR
mi
PISE)
GEIEI1L IIPOBIITIOI
faaala aged 73 It, and aale agad 16
»r. BaTlen.
TBILLIOR; HIT1LS; STORICR; PtOSTlTE;
IISTES; OTBBOS; OT1IXES; LTBFB BODES;
SIIIT1BT CHIOS: TBIBOIO Oil IDS;
ICBEItL QUIDS; PIICBBIS; PHBU
CHID; PITBITkBT G11ID; tOITI;
IllDDEI; Gill BltDDBB; GORS;
CIBTXIIGI; TEIDOIS; UGtBEITi; BOIES;
Sill; e»U; IIIIS; IITESTIIBS; IOIG5;
IDSCLESi SPIEBI; BE1IT; BB1II;
XIDIBTS; OIIIE; TEITI; LZTSB; BIOOD;
BIOOD SBBUB; 1DIPOSB TISSOE; BETIBI;
tOTOPSIBS
»bol« tooth and cnaMl. B«Tle>.
T81LLIOII; BETtLS; STOB1CH; PBOSTHE;
IISTES; OTEBOS; OTIBXBS; ITHPB IODES;
S»IH»RT OLIIDS; TBTBOID CHIOS;
ICIEIiL CHIOS; PMCBBtS; PHI It
CIHD; PltDTHBI QUID; JOBTI;
I11DDEB; Gill BltDDEI; GOBS;
CIBTIUOI; TIBDOIS: U01RBIT!; BOIES;
sill; Bill; Balls; IITBSTIIBS; LOIGS:
BOSCLBS: SPIBBI: BE1RT; BB1II;
(IDIEIS; OB HE; TEETB; IITEI; BIOOD;
81000 SBBOB; 1DIPOSB TISSOB; BETIEB;
10TOPSIBS
Icfcilles tindon. p«ial* aged 73 jc,
and »!• ag«d 16 it. B«»i«».
IBllltON; BET1LS: STOR1CB; PtOSTITB;
TISTBS; OTBIOS; OTIilBS; LlflFB IODES;
S11IT1IT nlllDS: TBTIOID OLIIDS;
IDIBIll OLIIDS; PlICBSaS: P1IE1L
CHID; PITDITIBT CHID: 10BTI;
BUDDBR; Gill B11DDEB; GOBS;
CIBTIIIGI; tHDOIS; LIGIBBITS; BOIES;
SIII; BUB; IIILS; IITESTIIES; LOIGS;
BOSCIES; SPLEEl: BUST; BB1II;
KDIBIS; OIIBE; TIRB; LITER; BLOOD;
BIOOD SBBOB: IDIPOSB TISSUE; RETIEB;
IDTOPSIES
t«aticl«a and «pididyai«. toad 16
jc. B«il«».
TB11LIOR; BIHLS; STOH1CB; PfOSTlTE;
IISTES: OTEBOS; OTIBIES; LTRFB IODBS;
SILIY1BT CHIOS; TBIHOID GLIIOS;
IDIBI1L GlllDS; PlICIBISi PIIE1L
(HID; PIIOIT1RT QUID: 10BTI;
BllDOBB; Gill BLIOCBB; CtJBS;
ClITIHG!; THDOIS ; UG1BBBTS; BOIES;
SHI; RUB; IIILS; IITBSTIIEJ; LOIGS:
BOSCLBS; SPLEEl; HEIST; BB1IB;
BIDIETS; OBIBB; TEZTB: LITER; BLOOD;
BIOOD SEBOR; IDIPOSE TISSOE; BBTIEI;
IOTOPSIES
BEPE1EICE
Carson, B.L.
Saita, I.e.
1977
Cation. B.L.
Saita, I.e.
1977
Canon, B.L.
Saita, I.e.
1977
Cacaon, B.L.
Saith, I.e.
1977
-------
Taalllaa
7MO-28-0
II
Itl 201.37. at 303.5 C. BP 1«S7 C,
n i •• my at «25 c. 10 •• 89 at 1000 c
TXSSVB
3037
Tkyrald
gland
3038
Dcla*
3039
OclBo
30*0
Otccaa
EIPOSUIB IOOTI
lag* at Ion
iBaLRicu.
BBTBOD
as
...
BS
COlOClaettr
US
BS
BDBBSB
or CISBS
1
•1 11
b| 2
C) 1
1
UHB
•1 <20-SOO eg/1
b) 130-3900 ag/1
c) lot applicable
Bill
al «5 «g/l
b) lot given
c) 10300 og/1
aEiiui iiroBiaTxoi
Iged 16 jr. !•*!••.
TBILLIOB; BBTILS; STOBICH; PtOSHTE;
TISTES; DtMQS; OTIBIBSj ITBCB tODSSt
SHXVIBI 011BDS: TBIiOID QLaBDS;
ICIZBlt BlIBDSi PIK1B1S; FIBBU.
CUIDi PITOITUT OIHD; »OBtl;
BIIODBI; Bill BL100BB; GOBS;
CIBTIUOI; IIIDOiSi UQABBBTS; BOIES;
SHI; BaXB; BKIS; IBTBSTIBBS] LOIOS;
BOSCIISI SPLEEI; BttlT; BSaXI;
IXDIEIS; OIXBBt tEITB; tlTII; BLOOD;
BIOOD SBBOBt 1DIPOSE TXSSOBi BBfXBB;
IOTOPSIES
a) Sripto*l«««. B«an
-------
laaophylllna (B ci)
1R-Pariaa-2.6-dioaa. 3,7-dib}dro-1. 3-diaathyl- (9 Ct)
58-55-9
C7-B8-»»-O2
It 180.17, gf 210-27* C
TISSUE
30»1
Blood.
plaaaa
30«2
Blood,
plaaaa
30*3
Blood.
plaaaa
EIPOS01E BOOT!
lagaation
Injection
lag* it Ian
alairrlCal.
RETROD
RPtC
RPLC
ec
1
1
BOBBER
or CISBS
•I 6
b) 6
C> 6
d) *
3
37
BalGt
•) 1.5-7.5 ag/l
b) «.0-19.0 19/1
c) lot gl»an
d) 3.0-U. 0 ig/1
a) 8.16-2.99 ug/al
b) 3.02-1.6C ag/al
•1 0-1.3 ag/il
b) *.0-«2.8 ag/al
(BBR
mi
D a. e ag/1
b| 10.7 ag/1
c) <0.5 ag/1
d) 9.0 ag/1
•) lot glrcn
bl lot gt*on
•1 1.2* » or - 1.05
«?/•!
b) 12.0 » or - 7.1
»»/•!
NQI)
Gtltltl IIFORBITIOI
•) Day 1 of troataoDt-lnfantf
b| Poak aaaaa aftac 0.5-2 ag/fcg/6 brr
adjutad foe plaaaa latola-ltfaota
c) Bafoca tcaatacnta-tnfanta
d) Paak aaaaa aftac traataant.
adalta. *00 ag/day
laaophrlllaa I caffalna corctlatad In
Infanta. TkaopkrlUna claatad 3 daya
aftar last doa*. caffaiu paialatad >
9 daya.
7 pcaaatara infanta, gaatatlcnal agaa
26-33 «k, tcaatad «ith th«opbyllin«
foe apnaa. • adalta, agaa 20-25 jr.
IlllCB; C»«»D»; THKOPBTLLHBS; OHOGS;
DBOS TBEilPl; IIF1ITS; JDOtTSj BLOOD;
BIOOD PUSBli COHPMtTITB
IVtLOlTIOISi LOIGS: BntBOLITBS;
IIIBOII; IIOIOHOSCOLtB DISEl'ESi
CIFFEIIE; ORBUIClt COID
a) tctaclal blood. 0 aad 3 hi of
haaodlalyala aftac Infaaion cf 250 ag
•ilBOphyllina
t) fanooa bleod, 0.25 and 3 ac of
kaaodlalyala aftac Infaaion cf 250 ag
atlaoparlliaa
Claacanea 86.1 al/aln
3 araaic patlanta en chronic
aaaodialfala. aithac anaphcic oc «lth
aad-ataga ranal failoca.
D108S; D10S TBBliPT; lOOLTSl
1BBOPBTLLIIIS; fLOIIDJ; BLOOI PUSH;
oiaartics
•1 Bafaca tcaataaat, 21 caaaa
b| Raan paaka aftac 2.*-8.« ig/kg/dar
foe avaraga of 103.1 he
Itfacta on ••condacy apnaa act
aigniflcant.
37 Infanta (ith apnaa. bocn la for a 37
•k gaatation.
lexlcitf dafalopad in 12: tacaycacdia
(21. cagacgitation oc SI blatdlag
(9) . coavalaiona (2) .
TBIOPRTLLIIES; DBOQ3; OBOO TBBliPT;
IIIIITSI rilBCB; BIOOD PLISII)
CCIPlllTIfl IfHOiTIOISi HITUOUnS;
IIIBOIf; lEOlOBOSCOlH DX5E1SBS;
CltFBIBI
ttTtsr.net
Boer. c.
Baltaaaat, P.
Poet ha alt, a.
Bathanod. R.
Pradacich, A.
acaada, J.T.
1979
Ching. S.L.
darbncy. I.e.
Paccia. J.B.
Fallac, T.J.
1979
Bo at coy, R.J.
Tact. P.
loyac. >.J.
Ronia, P.
loyar-Rorrot, H.J.
1979
Ln
O
-------
TBeophrlllne (8 CI)
1B-Farlne-2.6-dion«. 3.7-dihJ
-------
Tkoophrllino (8 CI)
1B-*arino-2.6-dlono. 3,7-dlhjdro-1.3-dli.tbyl- (9 CI)
•t-55-9
•;1-H8-R*-02
IS 180.17. It 270-27* C
(COITIIDED)
TISSOB
30 «7
Blood,
BO COB
30«8
Blood,
s.cai
EXPOSURE ROUTE
Injection
Ing. it Ion
Ing. Bt Ion
_
allLTTIClL
RETROD
RPIC
RPLC
RORBER
OP CaSES
6
la
RaROE
a) 6.85-17.227 uo/Bl
b| 3.11-6.91 ng/Bl
a) 6.6-15.0 ug/Bl
b) 5.0-13.6 og/Bl
c) 6.1-18.5 ag/al
d) a. 1-15.7 ag/al
REAR
a) 12.«18 » oc - 3.01
tg/al
b) 5.15 » oc - 2.12
ao/Bl
a) 11.1 og/Bl
b) 9.6 og/il
c) 13.8 og/Bl
d) 10.7 og/al
GEimi IIFORHITIOI
• I EltC«po!lt«d 0-tl» Talo»l,
cocracUd to IT bolai, «ft«r 1.8-».2
ig/kg IT. Bl«rpon«nti«l d«clin« (S
Mbjrcta)
t) Polk* tftor 3.2-1.2 «g/kg in
Ublot*. Parting to 5 kr. [oiks it
1.12-2.8H he (6
PitUnts 31-73 rr old, «lth racial
canal, kopitlc, and polionac;
function. Ill had eocobcal
dy«Canctlon« of lachoilc/Tiocalir
OElgln.
liasoi In 2 iftoc oral do«o. Hodoot
lipcoroiont of drsactkcii In 1 aftor
II dooo. Slight toipocaEf
lapcoTOMBt of ipastlc pacapaoiia in
1 iftoc IT dose.
IBEOPHILIIIIS! BLOOD SSRORj IOOLTS;
CCHPaltTITB IftLOillOIS; DEIUBK;
OIDIOTISCOIM DISUSES
i) »B, 6 kc aftoc 1.725-*.55 igAg i«
aaiaophrlliio lolitlon
b| PR, 6 kc iftoc 1.726-1.55 igAg as
ailnopkrlUn aolntion
c) iR, 12 he aftoc 3.15-9.1 f)/\tj a«
taiopkTllino, contcollod-coloaso
capaalo
d) PR, 12 he iltoc 3.15-9.1 igAg a*
tkaophTllin*. coBtiollod-colmio
capBBlo
Significant dlffocoaco botvooa HI and
IR tcoagki.
IOB-BBOkocB, ag«» 21-ao, no
alcokolLao oc cacdiovaBcalac dlBoaso.
DROSS; SBSCLB lELtllRSi
tBEOPHTLLIlIS; BIOCO SBBOH; IDOLTS;
COHPaRlTITE CTtlOtTXORS
BBPE9EKCI
liolMB-KadBk, P.
RignaBBoo. I.
Stiokolin Jon>on, T.
RIOBOC« K.
1980
losko, L.J.
BCOBBSOia, D.
Canada, l.T.
East mod. G.
1980
O
00
-------
TkMPkrllln*. co»d. >itk «tliTl«n«dla«in« (2:1) (8 CD
1B-»5rUi-"6-dioii«, 3.T-dlfcjaro-1.3-di.«thri-. eoipd. »ltk 1.2-.th.o.di«.tn. (2:1) (9 CI)
317-3«-0
C7-B8-I«-O2.1/2C2-IB-I2
•I «20.««. BP 276-278 C
TISSUE
30*9
Blood.
pltlM
3050
Blood.
MEH
KIPOSOIE BOOT*
Injection
iiiinictL
BETIOD
HP 1C
IOBBB1
OF CIStS
9
MICE
2.0-10.0 ug/il
•Bkl
lot 9if«n
oeintL iiroiUTioi
-
l«T«l* at «nd of doing intacial
daring flr*t 2 4«y» of
tc««ti«nt-lniti«l doo* of S ig/kg
nodj «t follond by 1.2 >9/k; «farr 8
•c. C«ff«in« !•*•!• capoctcd foe »
cm* (< 1.0-2.0 •9/il)
Sgbj«ct>, 26-32 «k gmtatlon*! »g«
Hi «*lgkiD9 MO-1,200 gi «t birth.
Tnatod for ipn«a ul br«dTc«rdi«
•»oclat«d «lth cfanosls.
DI08S] DI06 IBBBIPT; BLOOD PUSBli
IIFMTS; lllBOIIi IN YOIK
!•*!•«
Sid* «ff«cti glT«n for »*rio«» Mrai
!•*•!•.
flEOPBILLIflS; BET HI; HDSCLt
Etituns
lETIREICE
Dietrich. J.
Ireui, t.l.
Beidcnbirg, a.
Dnycr. D.E.
laid, P.i.B.
1978
Btaclai. B.I.
1980
Ln
O
vo
-------
a. 7-(2,3-aihT4roiypropylt- <8 CI»
1I-rarU«-2.t-dlon*, 7-(2.3-dthJdro»yproprl.)-3,-'-dl.hTdro-1.3-alBat»Tl- (« CT)
(19-18-5
Bl 251.25. HP 158 C
TISSOI
3051
Blood.
mean
BIPOS01B IOOTI
Inflation
nitmciL
8BTHOD
RPLC
10BBBI
or CISBS
5
nisi
2«. 36-1.6« 09/11
" Mil
lot tppllctbl*
OEiiiti inroiiiriof
ling* of naas 0.75-8 he *ft«r 19-28
• 9/kg. InltUl »«la«. 3.28 09/«1 «t
0.5 he. RoBMipOBmtttl ollilnatlon.
20-25 jfolt, h*«lthr. nonob«M,
•OB-*iokoc«, not taking ••dlcationa
and alMtainlag froi
•atkylxanthina-contalnlng foci foe IS
ki bcfoc*. fut«d.
ana knd savaca ha« dacha aaaodatad
•itk p«ak aaiaa !•*•! of 36.1 19/al.
DBOSS; TIBOPmtllSS; IDDLTSi CIltDti
RRU01I5I; 8MOD SBTOI
tmtxict
Slaona, K.J.
Sinona, f.E.B.
1979
-------
TkUioIl». 3-C(»-Mino-2-Mthyl-5-pyrl«moyl|Mthyl-5-<2-ky4ro*y«thylJ-»-.-«thyl- cklorU* (9 CI)
59-0-8
C12-B17-M-0-3. Cl
II 300. IP Hjdrochlori4« 2«8 C (tecoip)
TX330B
,
3052
OClBC
BIPO301B BOOTI
IMLTTICIL
BITIOD
-
IDBBB1
or CISBS
187
MIOB
•) lot glvm
b) lot gl*m
BUB
•1 951 «g/g
ccMtlalB*
b) 17B1 «g/g
crutlBlM
QIIII1L IIF011HIOI
•I l«n
b) loiw
Ccltccl* for Ion l«*«ls < 66 ag/g
CEcatinla*.
I«E«1 OtBhni, SB MB, 129 IOIBB. B*«B
B9* 69 yc.
DIETS J tl»CB BIBBBIM; CBOIB9TBBOIS;
MOOD SBIOli SZKi COPtn; PCTISSIOI;
SOOIOB; IMIISIOB; CllCIOB; HOI;
*mill t; TltiBIBS
nmncB
Fisher . s.
••atrlck*. D.o.
HikOBcy. l.l.
1971
-------
533-a5-9
ce-M-ci-i-s
Rl 161.ft, IP 232 C, BP 92 C at 7 aa
TISSUE
3053
BlOOd.
plana
30Sa
Blood,
plan*
EXPOSURE 10DTB
ingest Ion
Injection
Inge «t Ion
lllLYTICaL
8BTHOD
IS
OC
IDBBBB
or cts is
•1 3
b) 3
C) 3
4) 3
, ..
16
UIOE
•1 0.59-0.007 ng/al
b) 7.14-0.022 og/al
c) a. 16-7. 78 ag/al
d) (.23-31.5 ag/al
a) 7-36 ag/1
b) 3-36 ag/1
SBtl
•1 lot tppllcabl*
b) lot >ppllctbl<
c) 6.25 oa/il
a) 15.15 ag/d
•) lot glT*n
b) lot glm>
GEIIBtL IIPOIUTIOI
• I 0.5 «nd 10 he aftac 38« 19. oral
b) 0.5 »d 10 he a(t«c 768 19, oral
c| Pcaka, 0.17 and O.SS he after
0.32-0.«5 ag/kg/iln
a) taaka, 0.17 he and 0.«2 hr
(ostlnCnilon. Oo»«. 0.71-0.{2
•gAg/ain.
PatUata clth aild alcohol ulthdraval
•yadcoa*, agaa 1B-60 jc, ulthont
aavar* hepatic, r*aal, or cardiac
dTalaoctlon.
Sadatln cffacta ap to • hr after
d0*109.
CIOOS; SEDtTITES; BIPIOTICS;
IKICOIfOtSIITS! BLOOD PLaSII;
tCOLTS; alCOBOLIC BBtBSlOES;
CCBPataTIVS EULOJTIOIS; DBOC TBESIPT
a) Blgheat recorded
letels-ancoaacloaa patleota
t> llgheat recorded levela-all
patient*
llcohol taken In 6 CUM, otbar draga
in 3 cacea.
22-8* yr old patient* adaltted to
hoapltal after overdose. *
-------
fhiocraalc •eld. loB(l-) (B CI)
tblocranat* (9 CI)
302-0%-S
C-I-S
BI 58.08
IISSBB
3055
Blood.
MCU
Bxroson toots
IIUTTICIL
BETBOD
ColorlMtry
itraaEi
OF CUBS
•1 8
b) 8
IITCI
a) -T.S-2T.5 »g/l
b) 2.5-8 ig/l
mi
•) lot gli«n
b) lot glma
GBIIUL uroiatTioi
a) 5>ok«c<. >1 p*ck/dar 1 yz
h) loa»ok«c> >3 jl
l«tl»t*a fee* graph.
tdilti, ag«* 21 to 39 yc, none on
••dlcation 30 flay* prior to ttoly.
(ra« of naaco-, cacdiovaccolac,
tapatlc, aad nnal abnonalltlu.
IITICOIfDLSIITS; B100D 3BBDB; IE!
tout; SBi: laxocTiitTBS; saonio;
CCHPIBITUB MILDIHOHS; DI06S; DIOO
TBBIIPT; PIOIBIIS! TOBlCCOS: IDOIIS
IBFBIBICB
BOB*. J.Q.
Bacron, S.I.
Joako, l.J.
1978
-------
lkio«th*r (lo posting! ID CBIHLMB) .
TISSUE
30S<
OriB*
EIP03DBE BOOTH
1I1LTTXC1L
1BTROO
ColotiB*tCT
IORBIS
OP OSES
B) 16
b) 3
c) 20
d) •
•1 2
ft 2
BIKE
B) lot glVBB
b) lot gi*m
c) lot gif«B
d) lot giv«B
•) lot gi*«B
f) lot git»
•Ell
B) 37 OBOl/BlOl
crcatlalBB
b| 52 BBOl/BBOl
CCBBtiBlB*
C) 30 BBOl/BBOl
CCBBtiBlB*
d) 73 OBOl/BBOl
craatlnlni
•) 52 BBOl/BBOl
CnBtiBlBB
f| 71 BBOl/BBOl
CtBBtlBlB*
GEIEBtL IIPOBilTIOl
•ithoat •edicatiOB
H P«Bal« clccki - BBOk«r« with
••diCBtlOB
c) Hal* cl*rkl - DOn-aaok«cs vlUioat
•BdlCBtiOB
dl r«BBl* tic* b«lld«t« - radial
group, »lth abdication
•) RB!« CBbbtc vockBO - non-«iok«r»
«ith BBdicatioa
C) HBlB cabb«c »ork«r« - giokeci «ith
BBdiCBtiOn
OclB* Of BBplOf*** IB PiBBilb
chBBlcBl factorr.
OBIiB; OCCDPlTIOBal UltlDS; SHOKXIG;
PIBL1ID; SEI
BEPSBEICE
Tainio, B.
sa«olaiB«n, a.
Rilplkarl, I.
1978
-------
Thloxanthm«-d«lta (*. g«"«) -propylaiiM. 2-chloro-l,»-dl««thyl-. (Z)- <•
1-rropaaaala«. 3-(2-<*loro-9B-thioxaBth»n-9-rlli«B«)-l.»-aia«tliyl-. (XI -
1 13-S9-7
Cli-B-18-Cl-l-S
II 3 IS. 9, HP 9»-9S C
CI)
I TISSUB
1
3057
Bleed
BIPO30BB IOOTB
iBjactlon
lagvatloa
till, met L
IKTIOD
TlioroMtcr
IUBBBI
or c»s is
1
IlIGB
•) lot •ppllcabl*
b) lot •ppllabU
c| lot •ppllcmbl*
4) lot applicable
rail
•1 SO ng/»l
b) 3 D9/«l
e| 12 ag/hl
«) 1.3 ag/Bl
..
ciitui inoiattioK
at 0.5 he, intratanoua
bl 2* he, iBtraTuou
e) * kc (peak), oral
4) 2* be, ocal. Valuta dvecncad
ataallf (coa high *ala«. TalMa
•atlaat*d fcoa graph.
fkanacaklnatle profll* and
btoaTallabllltr data glraa.
laaltkr adult
ClflOSj BIOOD! SIXTZBBLUD; ttOlTS
BEFBtBICB 4
Baaflaab, J.
1975
Ul
M
Ui
-------
7MO-31-S
am
Itl 118.69, If 231.9 C. BP 2S07 C, V* 1 •• Rg It 1610 C. 10 •» Bg «t 1890 C
TXSSOB '
30S8
Bait
3059
3060
Kldauy
3061
llTir
BIPOS01E IOOTB
allLTTICU
IRBOD
BS
X-cay (Icon*
BS
X-eay floor**
IUBBE1
or CUBS
B) 126
b| 90
01 71
4| 179
•I 108
() 102
g) 109
a) 18
b| 8
e| 12
•I 36
b) 13
c) 31
nisi
a) lot glTiB
b) lot gl»*n
c) lot gltin
4) lot glTin
•) lot gl*«a
t) lot gi»«n
g) lot glT«B
B) lot gi»*a
K lot gi»*n
c) lot glrin
a) lot gl»in
b) lot gl»*n
c) lot glTin
B) lot glTin
b) lot glT«
e) lot gl*«a
" Biir" '
a) O.S» ag/g
b| O.M ag/g
c) 0.83 ag/g
4| 0.*7 ag/g
•I 0.77 ag/g
It O.S« ag/g
g| 1. 17 ag/g
Si OBI trie nans
a) <1.5 ag/g dcy *t
b| 1.9 ag/g dcy «t
c) 2. 1 ag/g dcy it
a) 1.03 ppi (31*)
b| 1.03 ppi (Ml)
e) 1.M ppi (55*)
a) 2. 1 ag/g dcy «t
bj 6.6 ag/g dcy nt
c) 17.1 vg/g dcy *t
GIIIBIL IirOIItTIOl
a) Loag Islaad chlldroa
b) Qn**na ehlldc«B
c) BCOBI children
41 gal* chl!4rin
•) null cklldrin
t) Hal* adults
g) Fiaali adalts
Cor rilat Ions bitvim SB aad thi
following: dut. MX. Additional
data.
scalp bale. Caucasians IB IT. ages <1
to griatir tkan 51 yc.
UTtLS; TIICB BIBHBBTS; B1IIDB;
BOBOI; CaDHIOR; CBIOBIOH; COFPBB;
IIOI; IBaD; tlTHIOB; HilGallSI:
BIBCOBT; IXCIIL; SELBIIDB; Stt»ER;
III; falaDIOl; IIICj Ball; a«B;
ICOLTS; CBIIDIBI; SBI; CORPaUTITB
imOHIOIS; DOST: SOILS; all
COUOTIOl; OIBal alBIS: IE! TORK
•) Cootcols
b) loadlalyxcd arailc
c) Olalyx*d anile
SiBplcs fcoi autopslis aod •Bd-stag*
kldnirs c*BOT*d at transplant.
Ill; BBTalS; LITEI; KIOIEIS; OBIIB;
DISSaSBS: COlOBtDO; aOSTBlLII; TBXaS;
CCEIBCIICOT
at lo coaal disvasa
b) acat* c«Bil (allani
c) Chronic rinal falloris
Dcy «t basis
E*cc«Bt of saaplis «lth d*t*ctabl*
lifels Is ladlcat*d la parentheses.
lutopsles at QCLa Bospltal.
IlaCB BLIRBITS; HEtkLS: IOTOESIBS;
CUIFOIIIl; IIDIITS; LITEB; SPtBEB;
DISE1SBS; BTPEBTEISIOI; SODIOB;
fOTlSSIDB; CaKIOB; PBOSPBOBDS;
BtGIESIOR; C1DSIUB; II 1C; COiPBl;
KaD; IIOI; RklQtIISE: aLOHIlOB;
SILICOI; TITIWOB; COBaLT: HCKBLS
CQITBDEIOB; Til; CBBOIIOB; S1BOITIDR;
BallOl; LRHIOM; SILTSR; tUlDIDB;
COIOI
a) Controls
b) loadialyMd anile
c) Or*ilc, dlalyild 3-80 10
Intopay sai;ln.
58 aaiples froi CO. 1* froi [Isbane,
listcalla. 7 tcoi CT, 1 froi TX.
Ill; BETaLS; LITEB; KIDIETS; OBIIE;
DISEaSES; COLOB1DO; IOSTE1LII; TEX1S;
CCIIECTICOT
ISPBBEICS
Criason, J.P.
Blnners, T.I.
Buagarnir, 3.1.
Plnkerton, c.
1975
Bannelley. L.L.
Saythi, I.E.
Ibils, L.s.
1978
Indrapraslt. S.
Ileian4er, O.T.
GOBletc, B.C.
197a
Bunnollej, L.L.
Sir the, I.B.
alfcey. t.C.
Ibils, L.S.
1978
.
-------
Ill
7MO-31-S
SI
l« 1ia.«9, IP 231.9 C, BP 2S07 C, TP 1 •• Eg at 1610 C. 10 » 89 at 1890 C
(CORtlDID)
n»oi
3062
liver
3063
L«ng
306«
Spleen
3065
Brine
BIPOSDIB BOOTI
lULTTICiL
BimOD
BS
BS
BS
X-rar floor**
IDIBBB
OP CaSBS
30
a) 9
b) 8
•) lot given
b) lot given
c) lot given
lot detectable-393.0 ag/g
dry «t
n) lot given
b) lot given
c) lot given
..
a) 2-29 ag/1
b) 3-31 ag/1
BBil
a) 1.83 ppa (66S)
b) 1.C9 ppn (70S)
c) 2.53 ppn (66S)
lot given
a) 1.19 ppa («SS)
b) 1.07 ppa (61S)
c) 1.22 ppa (70S)
a) IS ag/1
b) 15 ag/1
SBIIUL xtpoBimoi
a) lo renal disease
b) tcate renal failaree
c) chronic renal failure*
Dry *t ba.i*
Percent of .a. pie. »ith detectable
levels is Indicated in parentheses.
litopsles at OCLl Bospital.
TMCI BLIHBBTS; BITlLS; aOWtSXBS;
CILIPOIlIt; mlBIS; tXTBI; SPLBBB;
DI3BISBS; BIPBBTBI3IOI; SOOXOR;
ECMSSXOR; C1ICXDR; PBOSPHOIOS;
RtQIBSni; CIDRXDRt UK; COtPBI;
KID; XIOI; BMOillSB; UORIIOR;
SILXCOI; TXTinOH; COBUT: IICKBL;
BOLTBDBIOH; Til; CBIOBIDB; S1BORIOR;
BUXOR; LITBIOl; SILTBB: MUDIOB:
BOIOI
sectlona of lungs fron subjects »ho
had beea bitaninoas coal einars for
33-50 yr.
BBTILS; TB4CI HIRIITS; 1LOIIIOI;
Hildg; BSIUUOI; BOIOI; CRMBIOR ;
CCPPBI; BBBIIIiaH; IIOI; LBIC;
IIOIBSIOR; BIIQalBSB; IICKBL;
SILICOl; SILVBB; Til; TRalXOI;
VIUDIOH; LHMS; COaL; OIITBC ST4TBS;
QOUTI; RIlBlaLS
a) lo renal disease
b) acute renal (allure.
c) Chronic renal failures
Dry >t basis
Percent of saaples «ith detectable
levels is indicated in parentheses.
litopsles at DCL4 Bospital.
TIICB ILIRII1S; RBTILS; HDTOISIBS;
CILIPOBHa; IIOIBIS: LIVBR; EPLBBI;
CISUS1S; BTPBBTBISIOI; SODIOR;
PCT1SSI01; CaLCIOR; PROSPBOIOS;
BIOIB5IOB; CIDRIDI; STIC; COFPBI;
llaD; IIOI; UieallSI; aLOHItOH;
SILXCOI: tltlHDR; COBILTi IKKIL;
BOLTIDIIOI; Til; CIIORIOR; S1BOITIOI;
eillOH; LITIIOI; SILTBI; TaBUXDI;
tOIOI
a) Controls
b) londialyiad aresic
6 .«!«, a fe.al« controls. 7 .ale, 1
feaale areaics. ages 20-65 yr.
Ill; HBTtlS; UTBB: KIDIBTS; OBIIB;
DISBkSBS; CO toil DO; IDSTB4LII; TBX.S;
CCHECTICOT
BBPBUICB
Indrnpraslt, S.
llexandar, O.T.
Gonick, B.C.
197*
, ,
crable, J.T.
Keenan, 1.0.
lolovics> r.l.
Knott, I.J.
Rolti. J.L.
Gorskl, C.R.
1967
Indrapra.it, s.
tlexander. S.I.
Gonick, B.C.
197a
lunnelley, L.L.
llfrey* i.e.
Ibels, L.s.
1978
-------
TltanUn
7MO-32-6
ti
Itl «7.90. *P 16T» C, BP 3m C. »P 1 » 19 at 2180 C, 10 u Bg at 2*80 C
TISSUE
3066
Raic
3067
Udner
3068
llirac
3069
Lang
BXrOSUBI SOOTS
HILTTIC1L
RETROD
n
BS
ES
BS
•DRBES
Of C»SES
11
30
11 ICE
21.1-33.9 ppi
a) lot given
b) lot given
c) lot given
a) lot given
b) lot given
c) lot given
.
31.5-393.0 ag/g ACT rt
(HIT
SEIB
26.7 ppa
a) 1.M ppa (BS)
b) 1.52 ppi (10S)
c) 1.31 ppi (10*)
a) 3.09 ppi («*)
b) 1.2« ppi (21)
c) 1.95 ppi (6*)
Sot given
nan
GEItSIL IlTORRATIOl
Scalp kale
Conors fcoi 2 tillage* of Balka
Indiau in tk« laazonas Teccltoclei
of Tenenela.
BUI; TBBEIOSU; HETILS; TI1CE
tlBRBBTS; SOOIOB; UORXBOR; SI1ICOB;
CI10BIIE; POTaSSXOB; SCISOIOI;
miHON: TII1DIOR: CIIOBXOR; GOLD;
RalGilBSI; IBOB; COBILT: IXCUti
CCPPEI; ZIIC; 1ISEIIC; SELBIIOB;
IIOBIBI; lOrlDIOl; STROSTIOI; SXLTEI;
IBTlaOBY; IODXBE; CISIOB: BltXOBi
LIITB1IOI: CIBIOH: SlHaBIOR; RISCVIT
a) lo canal disease
k) icate canal failicei
c) ck conic canal failure*
Dry «t basla
Percent of aaiplai «ltb detectable
levels Is Indicated in pacentbecas.
litopsies at OCL1 Bospltal.
IBaCI ElBIEBM: BBiatS; aOTOPSISS;
ctiirosBXa: KXDBBTS; LITBB; aitat
DXSItSBS; BTPKBTEISIOl; SODIOR;
POtlSSIOB; C1LCIOB; CBOSPHOII1S;
iiaiisxoit caoaioB; iTBC; coir El;
IHD; HOB; III61IESE; UOIIIOH;
sincoi; tiTtnoH: COBILT; IXCKSL;
CCITBDEIOB; 1X1; CIEOBIORJ SnOiTXOR;
IIBXOB; LITBiali SI1TBI; VailDXOR;
eoaoi
a| Bo renal disease
b) Icate renal fat lares
c) chronic canal fallaca*
Dry it basis
Percent of saiples «ltk detectable
levels is indicated In pareatbeaes.
Ktopsies at OCL1 lospital.
TB1CI ELBHBBTS; HSTtlS; 1DTOPSISS;
CH.IF01II1; (IDIET3; LITE1; SP1BEB;
OISI1SIS; RIPBTBISIOI; SOOIOR;
COT1SSIOB; CllCIOB; PIOSTBOSOS;
I1EIBSIOB; CaDBXOR; XXBC; COCPBB:
II»D: IBOB: uiGiiisE; ILORIIDB;
SXLICOB; TITIIIOa; COBILT; IICIBL;
BOLTBDEIDH: TIB: CB1OBIOH; S1SOITIOB;
IIIIOB; LirgiOI; SILTEB; TlllDIOB:
BCIOB
Sactioaa of Ings fro* sabjects vko
kad baei bltasiaoaa coal liners for
23-50 jr.
IET1LS; TBICI ILEIIITS: 1LOHIIOH:
IUnH; BEITLLIOBt BOB 01 ( CIBOHXOB;
CCPPII: OEBBIIIOB: IBOIS LBICj
BIGIESIOB; BIIGIIEXE; IXCHL;
SXLICOI; SHVIB; Till TntROJi
T1BIDIOI; IOMS; COlt! OBITBC STiTBS:
OOliTI; IIIBBalS
lErEIEICE
Parkons, I.I.
Talandla, J.I.
Dianas, fl.
1977
Indrapcasit, S.
llexandac, G.T.
Oonlck, R.C.
197*
Indcapcasit, S.
llezander, G.T.
eonick. R.C.
197*
Ccabla, J.T.
laanaa, E.G.
fOlOllcS, F.B.
(nott, B.J.
Bolts, 4.1.
oorski, C.I.
1967
- .. -
in
M
00
-------
Tltinlni
7*10-32-6
Tl
It! *7.90. IIP 1677 C. IP 3277 C, TP 1 mm Bg at 2180 C. 10 u Bg at 2*80 C
(COITIHID)
TISSUE
3070
Ing
3071
Lang
3072
lang
3073
lymph
aod*
IIMSOU BOOIB
^
IBllRICll
HITflOD
BS
BS
BS
IS
BOBBEB
or c»s ss
20
•) 129
M 15
13*
_
1*
BIBSE
lot given
•) 26-158 «g/g dcv «t
b) lot given
90-158 *g/g «ry «t
.
Bot given
(•BIT
mi
158 ig/100 g dry «t
» 98 eg/g dcr >t
b) 22 eg/g dry it
115 «g/9 dcr »*
137.0 ig/100 9 drr *t
.
PI OB)
6VIBUL IIPOBH1TIOI
.
lacledee eppor *ed lover labu, »d
lyiph aad«* ot lug. IdditLcnd dtti
•?«ilibl«.
Sln«c« (or
12-50 re in l*l*lgk County, test
TlcglaU.
BIT1LS; TMCB IlIIBBTS! COIL;
innLiai; coMM: cnoaxog; COPPM:
tICB; IE»0; IkCBBSiai; UIUBISB:
IICKIL; TXTIBIOR: TtBlOIOl; HIC;
IOISS; COBPIIITITB (ntOlTIOB;
SHICt: QOllTI; 1TBPB BOOBS; 1EST
tueiBii
• ) Coil •!•«•
b) Control*
Section* of Inga fro* dec**eed coal
elaera «nd noi-co*l daec* from
B*l*lgk Coa>ty. IT.
BR1LS; TB1CB ItBBIBTS; COUj SILIC1;
BIBflLIOB: CBIOBIOB; COPPB1; XIOB:
HID; sioiisioi; atieiiBsi: ncms
TITtligil TIBkDXOBt nK: IDBOS;
COBMB1TITB tfllOlTIOIS; tBSl
flKHIt
Beige of eeiu. tddltlontl data
available.
Section* of langa fcoa deceaaed Beat
Virginia bltaalnoaa coal alnere.
BBTllSl TB1CB ELIBBBTSi COil; SILICt;
BIBItilVli CBBOBIOB; COPPBB; XBOB)
IHDl ItOBBSIOB: BIBUBBSII KCOL;
TITlBIOlt V1BIOIOB: UK; IONS!
CCRPtBtTITI BVtLOlTIOBS; tBSt
vnaiiTi
Cilionacy kllac lynpk node* (con
aitjecta nko k*d been Bltaniioaa coal
•laer* for 12-50 yr in Balelgk, te*t
Virginia.
RBTUSl TB1CB BLtlBBTSi COH;
BUnildl: COBlltj CBBOUDB; COPPBB i
IBOB; IBID; BIOBBSMB; BlBfltlBSl:
BICKBL: TIT1IIOB; 1UIOXVR; II 1C;
IHB6S; COBPIUTITI BVtUiflOBSt
3ILIC1; QDlin: 1TBPB BODBSi VEST
VnQXBIl
SIFEBBBCB
Keenaa, B.C.
Crable. J.V.
Saallvood. ».I.
Carlberg. J.B.
1971
Sneet, D.V.
Croa*a, B.B.
Crable. J.T.
Caclberg, J.B.
Lalnaart. B.S.
197*
Carlberg. J.B.
crable, J.v.
Llatiaca. 1. P.
Borrl*. B.B.
Bolt*. J.L.
Baaer. P.
loloilcs, P.B.
1971
Keeaan. B.S.
Crable. J.V.
Saallvood. I.B.
Carlberg, J.B.
1971
Ui
M
VO
-------
7MO-32-6
Ti
Itt »7.90. »t U77 c. BP 3271 c. TP 1 •• Rg at 2180 C. 10 •• 19 at 2»80 C
(COITI10 ED)
TISSUE
307*
SplMB
EIFOSOtE BOOTE
IRlLYTICal
RFTROD
IS
-
RORBSB
or cisss
uias
•I lot giT«n
b) «ot giT«o
c) lot gi»«n
HE1I
a) 1.e» ppi (11X)
W 2.9* ppi (9»)
e) 1.90 pp. (9»)
GEIEBIl IIFOBHITIOR
i) 10 i«nal
b) teat* c«nal failurx
c) ckcoaic c«nal (allures
Cty lit baali
;
-------
Tocopherol
1406-C6-2
BUCT coBPosmoB OBKBOIB 01 OBDBTBBBXBBD
TISSUE
30 75
Blood.
plaasa
3076
Bilk
BXPOSOBB IODTB
Injestlon
lltLTTICIL
BBTIOD
BEB
1SES
*
B1BGB
•) 0.339-1.15 ag/dl
b) 0.258-2.116 19/41
c) 0.250-0.75* ag/dl
0.22-0.50 «9/dl
BBKB
•I lot applicable
b) lot applicable
c) lot applicable
lot given
8BBBU1 IITOIBHIOB
•) Change 0-96 he. 25 units ct
dl-alpha toccphecol or Its aoatate
•stec at 1 and »8 bi. Ige less than
1 Ik
b) Initial and peak. 25 ag/dar tor 6
ik.
Peak. «k 2
e) Initial and peak
•k. Peak. »k 3.
Pceaatore Infants.
placebo foe 6
fllalllS: IIIBOMi BLOOD PllSBlt
tlLK; COBPIIITITB BTaLOlTIOBSt
IBHITS; DIBTSs BaniTXOBal
OIMCKBCIBS; BOTBXTXOIU. DIJOBDE1S
6 sasnles of breast illk
Bothers of pcenatnce infants
TITaBIBS; BBBBOBB; ElOOD PltSBlJ
BIIK; COBPaUTIfB EfllOaTIOBS:
IIPtBTS; DIKSt BOnlTIOBal
CIPICIEICIBS; BOTIZnOBU DISOiMBS
BBFBBBBCB
Bell. B.B.
BCOVB, B.J.
Bilnec, B.
Sinclair. J.C.
ZeparskT. i.
1979
Bell, B.B.
Broun, B.J.
Bllner. B.
Sinclair, J.C.
lepacskT. t.
1979
-------
lolu*n«-«lph«.2-4lMin«, 3.5-41lico»o-» («lph«) -cycloh««yl-« (
B>n»no»ln*, 2-««iBO-3(5-4ibro«o-B-c7cloh»*jl-B-»«thil- (9 CI)
35"»2-»3-8
C1»-B20-Br2-B2
Bl 296.26
- (8 CI)
TISSOI
3017
Blood.
plant
BXPOSOII BOOTS
IngMtlOB
tBILTTICIL
BETBOD
OC-BC
IOBBBB
OF C1SES
1
1IBGB
(8-1.15 »g/«l
OEIBB11 IirOIBlTIOl
t««c. 2-10 he «ft«t 2«-tg torn*.
DBOOSl BLOOD PLtSBt; BB1SOBIEEBT
BEIBODS; BIL6IDH
, l.P.
, L.B. B.
I960
-------
Tolu««-2-»ulphoo«il4« (lo porting* IB CRBmiBB).
TI330E
3078
Orin»
BXPOSgiB BOOTB
Iag*stlx»
IIILTTXCII
(•MOD
CC
B08BSS
or CUBS
«) 2
b) 1
11IGE
•) 97-10W
b) lot gi*n
nti
a) Bot 9i>»
b) 98«
SBBniL IBFOBUTIOB
a) Cniolitin p*rc«at of 1« 19 (0.2
•oyko) «xcc«t«d after » d*y« >•
OClflMl » ••ttbolitu
b| Camlttif* p*rc*Dt of 30 19 (0.*
•9A9) «xcc«t«d «ft«c 7 day* «•
orl9l»l co»fonna ufl ntibolltu.
DBDQSt BBTkBOlXTUi 01X11; OBITBD
IXBODOI
BBrBBBBCB
B«n«lck. i.e.
BUI, L.B.
Carlo*. D.L.
BillUu, B.T.
1978
to
-------
•total we (to po*ti*qs
TC 290. «S
nssn
811k
3080
•ilk
MSI
•Ilk
siposmn torn
-
..
iBaimcii
sprioo
ec
nc
ec
ec
••BUI
OP CUBS
al SO
bl IS
a «
1 of SI
al 27
bl 9
a 10
41 M
•1KB
a) 1.7-4S.S ppb
b| Bot fi*aa
e| Bat ai*aa
•ot alTaa
al 0-0.019 pp»
b| 0-0. »S7 pp.
c) 0.010-0.035 ppa
4) 0.001-0.0*0 ppa
•MB
bl 12. • ppb
a 6.8 ppb
a| 0.00* ppa
b) 0.915 ppa
c| 0.02* ppa
4) 0.012 ppa
C11IIU. IITOHITIOI
•) til aaaplaa
fcl Coloatraa
c| «-1t ak aftac birta of tafaat
I1U aaaplaa, aoapitals ia aibaa
Calo. I aaaplaa froa aalliagdal* a
*all«T la soataaca »OC»*T- •>
cccapatioaal azpoaar*.
tilt; IISECtlCtBtS; UCTlTXOt;
cnmiiitn BTDIOCUBOBS; CBIOBTBB
CKUIC cooonos: PRSTXCIBBS; BOBIIT
Iia4oa aab)«cta of onatar St. loviz.
BO, Mtcopolitaa acaa. »»l«a» aca
tetal of alpaa. bata, aa4 4«lta
fisricnss: cnonra OBCHIC
COBPOOBBS; »R; on: DIBLBSXI;
•mCBUMOCTCUIBIXUB: RTTaCnaa
tpaiiDi: me nssoai; coBruniTt
IfUltTIOIS
•1 cottoa. coca. aa4 saaaaa~fco*la9
b) coca aa4 cottoa area
c| Caca acaa
4) Caftav-acoilaf acaa, Bl Salvador
al-cl la caataaala. Bl9ba«t aaa of
pvatlcldaa oa cottoa.
CaataaAla aa4 Bl Salva4oc« aoaaa
ckoBoa to capvaavat aiCfacaat daiavaac
of aaa of pastidda*.
(coblaa ia tropical coutclai.
coatilaata to baalta affacta.
ICIICalTnl; CBMBIBB OBCadC
COBtOmS; CBOP HStlBV; OBT:
BTBUBXB; U SUnBQB: POOBi
CCBXllXBtTXOB; C«iTtBlU;
aiiicaioiocTcioiniiB; BimoBUB
B1OHBB; XBSBCTXCIBIS: BXIK;
••TBtnoBat nricinciis: nmcnBS;
ptsncni lEsnns
•Emocz
Bakkaa. l.r.
Joaaaoa. ».
Lia, S.J.I.
•cabcavtac, J.
Ocackar. B.
19T7
da caapoa. a.
Olsafaa-Rarzys* t.B.
19'»9
- -
K>
-------
Ictml BBT (lo poa-tl«i» im CIIBLIBZ) .
SO-2»-3
CW-I9-C15
n 35*.M
HSS»B
3092
Mlposa
3031
308*
30SS
•Upon
xirosm IOITI
• aairncu.
•mew
SC-BC
CC-1C
sc
ec
1
BVBBBB
OP ClStS
•1 1*12
b| MO
a) 2*
M 39
d 122
*| 9*
al 151
O 70
70
73
B1BCB
•1 < oc - 270.05 pp.
b| < oc - M.OC pp.
.1 tot aiTos
b) tot 9lTo.
e> tot 9iTaa
4) tot aim
a) tot 9l»aa
O tot alraa
0.»-23 B*/kf aztcactabla
fmt
a| tot gi*aa
b| tot f 1*00,
(BBIT
SSAB
•1 7.88 pp.
bl «-99 pp.
M 29.29 pp.
d 23.0* pp.
41 23.22 ppa
•1 2S.T5 pp.
O 17.85 pp.
(.2 >9/*9 aitcactsbla
fit
.) 2. 51 pp.
bl 3.W pp.
ricn
CBBtBll. IBMBUtlOB
•) n 1970
b) n 197*
coaca.tr.tlaa o. llpid basis.
•ostBoct.as aad blopslas tsccaqkavt
I.S.
BUI; PKSTICIBES; 1DITOSI TI5SIX;
BF»BOURS; CHOBIIX atcuic
COBVOmS; CttOnitTB nOIOCIBBOVS;
IlCTlTIOB; OncnOIMII: BIT;
ICBICILOB; BBPTtCBLOl IfOZIVt:
EIILB8ZI; BEUCBIOBOCTCIOinUB; DDE;
BBITIB STIT1S
•| 19«9
b| 197J
el 19C9-72 ((•>«!•*)
41 19«9-72 |aal«s|
a) 1M9-72 fmleu-taadaul
Mmls «ra on »t. 1»{BB«»IBI)
IB 19C9-72 U tha lame Bio Gr«>d*
t.ll.T at •oMbaast Taias.
risnciBts; our; urnrazoB tronoB;
cnoBin OBCIBIC COOOBBBS; unosi
On; BOO; BttUBIl; tOLTCnonBlTtD
tnanru
IMoaiaal tlss*.
Saaplas fro. a4«lt aalos oaiocallr
altfocoacvs al9*lf least at 9!V !•»•!
1* oa*«cal casas.
Bovtlaa Mcraasias af advlt a«b)acts
>J» fr o!4 at 2 still bone t*
Doasark.
PtStlCtOU; OR: •IBUIIli
icitcnonitin antms: c&otm
QBCUIC coirciBBS: tnfos* TISSII;
flail; LXVtl; COBPU»TI»1
B»U»XOBS; iDBlTS; BIIBOBB:
BBB8UI; SI I
a| Bat Ussaa
fcl Pat tisma
C.ta aiallabl* foe a 9. aad sax
latapatas (COB sabjacts < ac - 82 jr.
(caa tart aa« Jiraskrla. Plslaad.
tlSTtCIMS; OR; ON; KttTCBIOBIBiTID
tnunu: ctMini OICIBIC
coavoms; cnoBiBtrsB BTBIOCUBOBS;
IOI*On TISSBB; (Bill; UTII:
iciorsns; cooviunn rraiianaa:
lei: stl; riBUBB
BErZSBICB
(atz, F.».
Stcasssaa. S.C.
Tabs. t.I.
••cms. J.I.
(acla9. O.
197t
Battala. I.L.
Xktala, J.
Isosakl. 1.
•aatta, I.
arstlla. I.I.
ro
Ul
-------
total DDT (la poetlag* ll CIBII.ni).
50-M-3
CU-lt-O.5
II 31*. SO
(COITXIOID)
Tissai
3988
idipoee
3087
adlpon
3088
(loot
308*
Blood,
plina
30*0
Blood.
•hole
HKSVII MUTI
IlhllatlOl
Ing**tlot
IHLTTICal
itnoo
ac
oc
8C
ac
cc
ac
IOBBBB
OP CISBS
•1 33
t» n
••
2*
a) lot
given
b) 10*
c| 315
iiiei
•I lot given
bt lot given
lot given
•1 8-78 ppb
b| 3-76 ppb
c) lot given
1) lot given
lot given
a) lot given
b| 0.00«-0.102 ppi
c) 0.001-0.08* ft*
Mil
•) «-1 ppe
bt 2.3 ppi
S. 83 ppi
•) lot given
b) lot given
c) 32 ppb
d) 25 ppb
0.9710 ppi
•I 0.032 ppi
b) 0.032 ppi
e| 0.016 ppi
aimii HPOiBaTioi
•1 Oreenlander*. 20-75 re old,
•»ple* tik«i dicing acute
laparotoile*. Level* hlgbor In 22- • 5
}C Old!
b) 0«nu, 1-75 re old, ndd«n 4««th
kj •ileld* oc In >«to accident*
8«dUn *•!«•«, baud 01 llpld lit
Ht >t »«lu«» tialltbl*.
Gc*«nltid ncnlnduitclillxod »r««,
klgh tobacco coniinptlon
Mnuck IndactclaliMd.
ICXPOSI TXSSOB; tOE; 1010P3XZ3!
ceioitiE oiotnc ccaponiDS:
fIStlCIDES: DDO; DtT; 008! DXILDUI;
HPtlCnol MOIXOI) KlTCnOIIIHID
tiPBiins; cospiimn BTILOWIOIS;
(OPOUTIOI BIPOSOIB: OHIILIID;
B1IMIK
S»pl*i tcoi aitoptlo* on accldont
victim lltlng In locfolk Comty,
Canada. Significant correlation
t«t»««n !•>•!• In tat and blcod.
CCT; DOB; ODD; PESTICIDES; BIOOD;
10IPOSB IXSSOI; ClUDa; OCCOHTXOI1L
RIUIOS; 10TOPSIBS: BI01CCOBILITIOI
-
a) Coed, black*
b) coed. ihltM
c) latccnal, blacka
d| latmrnal, vkltai
s«t» of naticnal and aabillcal coed
tlood*.
CETi BLOOD; OIBIIICU COBD) UCUL
S10DIB3S PESIXCIDZ 1BSIDOBS;
CORPkllTITE EfltOllIOIJ; DDI
Blgkic p«cc«ntag«i of ocganochlocla*1
lna*cUcld«« and PCB'« In illk of
•other* 20-29 year« than 30-39.
altkovgk the toraer had lone levels
In plaiia. o»«c Height voien had
Ionic !•**!• than noeen of nccial
Height, leiidae* concentrated In
eitcacted llpldi of plaiaa and illk.
laraell vonen 2-» d»r« after noreal
dalltiry.
PISTICIDBS; BIOOO PlkSlt; BIIK;
POPOLMIOI EIPOS01B; t Sit EL;
CRLOIXIITID BTDIOCUBOIS: LinDS;
1GB; DDtj DCD; DDIi POLTCatOIXIaTBD
BXPBHTtSi BEPTaCBlOB SPOXIDf;
BEIICBIOBOCTCLOI IX HE
a) Saiplei fcoi autopiiea an accident
•ictlia living In lorfolk Coontf,
Canada. Significant correlation
tetveen level* In fat and blood
t) Healthy lorfolk count! ceildent*
c) Realthy Holland Harah residents
CCT; DDE; ODD; PESTICIDES; BIOOD;
IDXPOSB tISSOB; ClHDl; OCCOHTIOIIL
I1IIIDS; tOTOPSIBSt BIOtCCOBOlaTIOl
nranicB
Jenoen, O.B.
Claaoen, J.
1979
Bcovn. J. B.
Cho«, L.I.
1975
Sandifer, S.a.
197*
Poll*hik, Z.f.
Bon. B.
•i***riann, B.
Cocoa, s.
•aiaeriann, D.
leiecch. C.
1977
Broun. J.B.
Chow, L.I.
1975
1
(HIT PICK)
NJ
-------
total ODf f 10 poatlaoB IB
50-29-3
CIB-M-C15
II 35*.50
(COKIIOBD)
man
3091
icaln
3092
Bcala
3093
tlrac
309*
Line
' —
Htomi lore
1I1LRIC1L
atraoo
oc
oc
gc
... .
oc
101 Ml
OF CI5BS
77
B1
77
73
UNB
0.013-3.2 ao/kg
•xtractahl* fat
al tot al»«a
b) lot glim
0.62-22.0 agA»
•xtcactabl* (at
a) lot glra
b) lot gl*aa
(isn
RUI
-
0.70 ag/ka
•xtractabl* Cat
a) 0.10 ppi
b) 1.18 ppa
6.0 ag/k? aiteactablo
(at
a) 0.22 ppi
b) 3.38 ppa
P10I)
SIIHIL IITOIUTIOI
-
S»pl«a (col adalt aalaa gcaarallr
lad kigacat cOBnntcatlona. MI
dif(«r*BC«a •IgalCieaat at 95* !•*•!
la MT*cal cuu.
loatln* »ctopal«a o( adalt nbj«cta
>2» yc old aid 2 atlllbocu la
Ocaaack.
PtSTIdDZS; DBTl DntOIXIi
lOLTCELOHIItlO BXPIHIIS: CttOUIB
oianic coitoaiDS; »DIPOSB tissmt
Hill; HTBIj C08PU1TITB
(T1LOUIOIS; IDOITSJ IBIBOII;
DCIBHIl SBI
a| tat tlu»
b) rat tl«»n«
Data aTallatl* (or af« aol a«x
gcoapi.
lotop«l«i (coa aabjccta < or • 82 re.
ftoa Pocl. rlnlaal.
PESnCIDIS; DDT; DDB; POLTCRIOIIIkTED
emiHLs; cnoBxie OIMIIC
COINOIDS; CUOIIHTBD BTDIOUIBOIS;
IDIP03B (XSSOBi BBtXB: LITBIt
I010PSXBS; COBPIHTITB KTltOIIIOIS;
161; SHI; rXIUID
_
Staplaa (coa aAalt aalaa gaaacally
lad kigaoat concvnt ratios*. s«x
al((ac«Bca« il^nldctnt at 9«* 1>T*1
IB aa**cal cama.
loatlaa acecopslaa o( adult nbjacta
>2« yc old and 2 •tlllbocoi la
Dtaaack.
USTICIDBS; DDT; DXBUIXI)
ICITCILOUIITID BXPinTlS; CfLOUIB
CIGUXC COBPOOIDS; tDXPOSB I IS SOB;
Elttl; II T HI J COBPUHXfB
BMLOiTXOIS; MOLTS) IIIBOII;
DIBBlIK; SSI
i| Mt tlaai*
b) rat tlaaaa
Cata avallablo (oc «q« and aai
gcoapa.
lttopal*a (coa aabjaeta < oc > 82 jf,
fcoa Foci aad Jrvaakyla, rlalaad.
PtSTICIDBS; DDT; DDB; POLtCBlOIXHTBD
EIPBBITLS; C1LO8III OBGtIIC
COBPOOIDS; CBLOSIIITBD RTDIOUIBOIS;
ICIPOSB TISSOS) BBlII; LITBB;
IOTOPSIBS; CCNPtBillTS BT1LOITIOIS;
>«H; SBI; rilltlD
•muici
Icaal. I.
(aclog, 0.
1976
Battala, 1. L.
Xkkala. J.
Xaoaakl. B.
Baatta. «.
acatlla. 1.0.
1976
Kcaal, I.
Kacloa. 0.
1976
Battala, a. L.
Xkkala, J.
Xaoaakl, B.
Baitta, K.
icatlla, 1.0.
1976
Ul
t>0
•vj
-------
ToUl DDT (lo poatiB9* in CHHUCTB).
50-29-3
C1*-B9-C15
Bt 35*.50
(COITIIBED)
TISSUE
3095
•Lit
3096
111*
3097
lllk
30*8
Bilk
BIPOS01B BOOTB
1IILTTICIL
BETBOD
OC
TIC
IOBBBI
or cists
.. ..
57
29
al 55
b) «2
O 13
•I 50
b) 15
e) 6
-
atioB
0.02-2.76 ft*
lot giran
•) 0.0-0. 298 B9/9
b) lot glTan
c) lot gltaa
•) 5.2-3*9.0 ppb
b) lot gi»«n
e) lot glT«
BEll
0.3* ft*
0.0717 ppa
O
•) 0.11* *9/9
b) 0.101 09/9
c) 0. 1*6 B9/9
II 81.7* ppb
b) 9*.0 ppb
c) 55.6 ppb
GEURlt IirOIHtTIOl
lactatlog noaan in Mlcctad *i*tm of
Itkauaa Bad Riaalaalppl.
BILK; PB3TICIDBS; iDIPOSB TI5SOB;
BITABOLXTBS; CBIO1IIB OlGllIC
COIPOaiDS; CB10BII1TBD BTDBOUBBOIS;
IICTMIOI; OIICBIOID»BI; DDT;
lOHCRtOB; BIPTICHIOB BPOXXDIl
OtILDIIli HIIlCBlOtOCTCLOatlHB: DOE;
imists; BISSISSIPPI
Bi9h«c patcvntag** of or9tnochlorin«
lBMeticld«> and PCS'* In illk of
•othvr* 20-29 r«ac« than 30-39.
altho«9k th« focMr had lo««t !•*•!•
In plaua. O*«c*«l9ht >oa*n had
lc««r luivli than «oa«n of ncraal
night. i««ldn*« eeao«Btrat«d la
• Itcaeted llpUa of plasa* and ailk.
lacacll «OB«B 2-* days aftac Boraal
PISTICIOBS; BLOOD VUSBt; BIIK;
POPOtlTIOl EIPOSOBI; ISIlBt;
CBLOBIItTBD BTDIOCalBOIS; LltlDS;
l«l; DDT; 010; DDI; WtTCBlOflHTBD
•XPBIITLSi BIPUCBLOI UOIIDF;
BIXlCnOIOCKlOBRIIB
a) SBOk«c> ploa BOB8aok«CB
b) BoaiBok«E«
c| Saok«r*
IOBCB ia «aat«rn PtDBB^lTa
pc«doBlBBt«l} liddl* claaa, aaaa
•daeatloi 1*.* yc
DDT; PBStlCIDBS; Bill; PBIISUTUIas
SBOKIIO
a) til MB
b) Coloatcaa
c) 9-16 »k att«r blcth of lafaat
Bilk «aapl««, boapitala la atbaB
Oalo. * aaaplta fcoi Blallagdal, a
•all«T la •oathcn lorvaf. io
cccapatioaal «xpoaai«.
BILK; IMICTXCXDlSl LlCTlTXOI;
CBMIXHTCD BtDIOCllBOIS) CBIOIXIB
OI01IXC COBPOOIDS; fBSIICIDBSl IDIIIT
(HIT MSB)
BEFEBEICE
KotI, P.I.
Stcasaun, S.C.
lobs. «.B.
1976
Pollshak. X.I.
Boa, B.
laaMcaann, B.
cocoa, s.
•asmraaBn, D.
Lcaaach, C.
1977
Ul
to
00
Iradt. P.T.
Mrrcnkohl, B.C.
1976
Bakkan, l.p.
S.lp, B.
1976
-------
Total DDT (lo po«ting« ID CBEBLIIBI.
50-29-3
CM-H9-C1S
•I 351.SO
(CORIfOID)
f tISSOH
3099
Bilk
3100
Bilk, fat
3101
•Ilk,
•kola
EIPOSOIE tOOTB
_
IHLITICIL
BETIOD
ec
_
oc
BDBBH
or CISBS
•1 27
bl 9
e) 10
1) IS
•1 10
ti 10
91 *0
•
•1 14
bl 5
cl 18
al 14
bl 5
o| IS
ItME
•1 0.3*2-4.97 ppl
b| 1.17-6.ce opi
c) 0.411-1.77 ppi
4) 0.025-1.03 ppi
•1 1.14-6.60 ppi
t| 0.600-9.26 ppl
g| 0.062-1.96 ppi
•) lot glT«n
b) lot gi»«n
e) lot giv«n
•1 lot gi*«n
b) lot gi*m
c) lot given
nil
•1 1.80 ppi
b) 3.06 ppi
c| 1.11 ppi
d) 0.480 ft*
•1 2.SS ppi
fl 3.S4 ppi
g) 0.69S ppi
•I 3.S 19/kg
b) 2.9 ig/ks
e) 2.8 ijAg
il 0.11 ig/kg
bl 0.088 igAg
c) 0.086 ig/kg
GEintL IIFOIBHXOI
.
•| Cottoi, cetn, «nd auai*~grovlng
•r«»
b) Con and cotton «r«*
c| Corn «r««
d) Qnitnili Cltj
•I Eanini am
(| cotton ana
gl coff««-gro«lng «r«a, Bl Salvador
a|-() in Bnatciala. Ugh*«t as* of
p««ticid«« on cottoi.
Rctb»ci ftoi lon-lncoi* f*illi«i in
Gnatcnala and 11 Salvador, ana*
choMa to c'pnnnt diff«r«nt d«gr«»
o( u* of p««ticld««.
OMC«B* of putleld«a a pacticalac
probloi in tropical cotntrlii.
Pr«ral«c« of aalnatrltion niy
ccntribato to honlth •ftocts.
iniCOLTOBE; CBIOIIIE OMtllC
COBPOOIDS; CIOP DOSTIISi DDti
CIEIDIII; IL SalTkDOIl MOD
CCITtBXItTXOI: GOkTIBlU;
imCllOIOCTCtORIXMB; BBfliCBLOB
IVOIIDE; XISECTXCIOISt B11R;
IOTBIIIOHL DEflCtHCIES; PESTICIDES;
(ZSTXCXDt HSXDOBS
•I Pool«d saipl**. 1967
t| Pool«d ««ipl*a, 1968-1969
c| pool«d aanpl**. 1971-1972
ic»n in Stockholm, Sv«d«n
PJSTICIDES; POPDllIIOI EXPOSQE;
IHKI DDT: BC8; BICiCCOBOLlTIOl;
SIEDEI
•) pooled saipl«>, 1967
I) pool«d »lpl«a, 1968-1969
c| Pooled xiplei, 1971-1972
Bonn in Stockholi, s»d*n
pinxcxvisi ropounoi EXPOS OIB;
Hill DDT; DDI; IXOtCCOBOLlTXOI;
SBBDBB
inniicB
d* Caipoi, B.
Olixraa-BariTB, 1. 1.
1979
(••too, 6.
1974
•••too. G.
197«
l/l
ro
vo
-------
ItrptophaB. S-hTdcoir-. L- (6 CX)
t-trjptoph«n. 5-hrdcoxr- (9 ci)
I350-01-6
C11-B12-B2-03
II 220.22
TISSUE
3102
Blood.
plaiia
EIPOSDRB IOOTB
Injection
aBUTTicki
BBTBOD
B»IC
PlaocoMtry
BOBBEB
or CISBS
5
B1I6B
28-0.22 aiolvs/1
RBiB
Bat tpplictbl*
QBIBBtL IIFOBBITIOI
0.25 to 9 he «ft« 0.2 ig/kg by
JO-iin If la p«tl«nt« an SO 19 t.l.d.
cKbldapt
CoBtiB«o«> iaCaaion data alco 9iv«B*
P«tl«nt« «it« • roc Ionic 4i«onl«t«
• 1th Bocul blood. HT«C. tat kldn*y
(•notion. >«•• 19-52 jr.
liaMa and toiltln^ In patl«nt> on
contlnnooi Inftilon. Intolintarr
•of«imt« r«dac«d.
CBOQS; BLOOD FLlSfll; DBIBHK; i DOLTS;
IICBOBOSCOIIB DISSISBS: 1BZBC 1CIDS
BtrEBEICE
nagnoe»B, I.
«l«lMn-Kud«k, T.
1979
U)
o
-------
Octal 1. S-floaca- (8 CD (Ml)
2.«(1B.3!)-trrlBiaiB«aiOB«. S-flmro- (9 CD
51-21-8
C«-B3-P-»2
I* 130.01, ft 282-283 C fteceap)
TX330E
3103
Blood,
piMBt
ixfosnn loon
InJcetloB
iiURicit
I1TBDD
BPIC
IOB8B1
or CUBS
8
B1MB
•) 26-123 Bg/Bl
b) 17-»3 Bg/Bl
c) «.8-26 ig/Bl
d) 2.6-19 Bg/Bl
•) 0-6.3 ag/Bl
.
RB1B
B) 61 ig/Bl
b) 27 Bg/Bl
cl 13 Bg/Bl
d) 7.S ag/Bl
•) 1.7 ag/Bl
aillUL IIPOIIITIOI
«) 5 BlB BftBE iBJBCtlOB
b) 10 Bin «(t«r iDjcctlon
c) 20 B!B «ft«c inaction
d) 30 BlB B(t«C 10>CtlOD
•| 60 BIB «ft«r iBjrction
•BtiBBtB IB CliBiCBl OBCOlOgJ HBCdB
e{ OaincBitj Boipltala in BBdlBon,
II, «9»» 36-72 TC.
Dioos; cmcnoais; t DOITS; iiscoisin
CBHOTBBBlPT
BBFBBBBCE
H«cBllI«n. I.E.
•olbwg, I.B.
(•lllag, P.C.
1918
-------
Ocacll, «-»eopTl-2-thlo- (9 ci)
*|1R|-Pyri«LdUoi». 2,3-dlhfdro-«-peopTl-2-thlo*o- (9 CI)
S1-S2-5
c7-Bio-B2-o-s
SI 170.25
TISSUE
110*
Blood.
neat
310S
Illk
znosais IOOTB
Ingcition
Ingutlon
UILTTICIL
BBTROD
colorlMtey
Coloclutry
IOBBH
or CISBS
9
.,
9
UIOB
7.7-3.9 ag/ll
0.7-0.5 ug/il
BBIE
lot gl»»n
•at givvn
GB»»L IIFOBRITIOI
1.5 and • he ••&!» after 400 ag.
Iiitlal f«lat, 0.8 ag/il at 0.5 hr.
Mtliatcd tea* gcapha.
Lactatlng, (atkrcold, health; vonn,
1-8 lonths afttc a«lir«ry, ag*s 21-3*
yc. 2 tc«at«d (or Graru dlnaa*.
DBOGS; BILK; BLOOD SEIOH; IICTITIOI;
Dtl»BK; BBHT8 B1I»HDS
1.S and * he i«ana. Initial »«lu«,
0.55 ag/al at 0.5 he. Oo»«, 100 ig.
* he •xccotlon. Bean of 0.025* of
doM. B«tl«at«d feoa graphs.
lactatlng, •athycold haalthy HOMD,
1-e ionth« aft«t d«ll*«cr> agaa 21-3*
jr. 2 toatid for Geafoa dil*ia«.
OI06S; BILK; BLOOD SEBOB; UCT1TIOI;
DCBRtlK; BEILTB BtltBDS
1SFEBBICE
Kaapaann, J.P.
aanan. J-B.
Johana«n( K.
B«l«ag. J.
1980
Kaipunnt J.P.
Banaen. J.B.
Johanaan. K.
B«l*«g, J.
1980
LO
NJ
-------
falarlc acid. 2-propyl- (8 CD
Fentanolc acid, 2-pcopjl- (9 CI)
99-66-1
CB-B16-O2
II 1M.21. BP 120-121 C at 1« » Rg, 128-130 C at 20 aa Hg
TISJOB
3106
Blood
3107
Blood
3108
Blood,
••CM
3109
Blood.
••CM
-
BXPOSDM BOOTS
Tn9*«tioB
Tn9**tlo>
IngeatlOB
Ingaatloa
IBILTTIC1L
RETROD
OC
oc
OC
IORBM
or cuis
i
c
2
23
IIBSI
2«.5-3.3 ug/al
(1-108 ug/al
_
•) Bat glT«
b) Bot glfan
e) Bot gitaa
d) Bot giitan
•) Bot glvea
_
a) 27. 9-3. S ag/Bl
b) 11.2-3. S ag/il
c) 33.1-3.5 og/al
4) 10.2-3.7 ag/il
(BUT
ati
Bot gl**B
Bot applicable
•I 22.2 ng/Bl
bl 22.3 ug/il
c) 15.6 ag/al
d) 9.9 ag/Bl
•) 3*. 3 ag/al
•) 10. SI ag/Bl
b) 10. SB ag/al
c) 12.60 ag/al
d) 12.0* ag/Bl
nan
GEBIUL IBFOBBHIOB
Bcther, peak at 1.5 hr and In at 24
kr aftar 500 ag. Talaaa aatliatcd
froa graph.
27-yr-old «oa«n «lth petit aal, focal
aotor aalxarea, and occaaloaal grand
aal flrat seen at 33 «k gaatation.
Infant delivered at 39 »k.
CBBOOB; OBOCS; DB06 TRBBaPI;
tllCEBTI; fttOS: BUI; HIBOSR;
IIFIBTS; BBOBOROSCOLIB DISEISES;
BIOOD; BLOOD SBBOH; IBTICOBTOLSUTS:
HClkTIOB; OBBILICIl CODD
Stiady atat* 1«»«1«. 21 con»«catli«
doau ««c«: do»«» 1-7, 250 ag
t«lc*/d«T> to*** B-ia, 500 ag
t«lc*/dar. do»« 15-21. 750 ig
tuin/dar. Bot (xpllcltlr «tat*d that
blood va* th« tl*«a« nmd.
6 haalthr adnlta. ag«a 22-23 yr.
Idnra* cantcal nacroaa «j«t«a
•ffacta In all « c«««« on 1000-1500
•g/day.
oiaas; DSOC taiBiPt; BIOOD; IDOLTS;
BlSaiBGTOB; mXCOBTDtSlBTS;
PSTCROTBOPIC DBOCS; BBBtTIOB
CISOBOBBS; CZBTBU BIITODS SISTBB
DISBtSBS
a) Infant at birth, 6 he aftar 2SO ag
b) Coed at tlcth, 6 he aftac 250 ag
c) Rotkae at birth. 6 he aftae 250 ag
d) Bothar 62 he attac birth. 16 hr
aftac 250-ig do««
•I Hoth«c 130 he aft*c birth, 3 hr
aftar 250 ag doaa.
27-yc-old voaan Kith patit aal. focal
aotor aalsiraa. aad occaalonal grand
aal firat >aan at 33 »k gaatatlon.
Infant dalitarad at 39 «k.
CBBOOB; OBOOS; DBDC TRBBkPT;
PlICBfTI; rSIOS; RIU; IBBBOII;
IIHITS; BBDBOBOSCOltB DISUSES;
BIOOD: BLOOD SBBDB; HTICOITHLSlttS;
IICT1TIOB; OBBILICU COBD
•) O.S aad 36 hr attar 250 ag aa Ba
aalt IB aycap, faitlng
b) 0.5 aad 36 hr attar 250 ag aa Ba
aalt la (Trap, aftar aaal
c| O.S aBd 36 kr aftar 250 ag aa Ba
aalt la ayrap, f«d 2 hr after doca
d) 0.5 aad 36 kr attar 250 .ag IB
capaala. fad 2 hr aftar do»a
Baalthy aalaa, OB no othar
aadlcatloa. faatad oraralght, 21-31
Tt old.
DIDOS; BLOOD SBBOH; (BTICOBTOL3UTSI
IDILTSt COBPIBITITE ETtLOiTICBS
BEFEHBBCE
Dicklnaon. B.6.
Barland. B.C.
Lynn, B.K.
Salth. B.
Garbar, B.
1979
Bovdl*. T.».
Fatal, I.B.
lilanaky. «.J.
Coafort. c.
1979
Ui
U)
LO
Dlcktaaon. B.O
HarlaBd. B.C.
Lynn, B.K.
Salth, B.
Garbar. I.
1979
Chan, l.B.C.
Roffaan. D.J.
Frladaann, B.
Carrlgan. P.J.
1980
-------
talerlc acid, 2-propvl- (8 CD
Pentanoic acid, 2-propvl- (9 CI)
99-66-1
C6-H16-O2
HI 1M.21, BP 120-121 C at 14 aa Rg, 128-130 C at 20 aa 89
(COITIIOID)
TISSUE
3110
Bilk
3111
Placenta
BIPOSOIt BOOtB
Ingestion
Ingest iOB
llaLTTICIL
RBTIOD
OC
OC
I0RBE1
OF C»SSS
1
1
BUCK
at lot given
b) lot given
lot given
IEII
a) 0.18 og/al
b) 0.«6 ag/al
5.2 09/91
GZMBll ZirORBkTIOl
a) 62 he attac bicth, 16 hr after
2SO-ag doae
b) 130 hr after birth, 3 he after
250-ag do»«
21-yc-old «oaan nitli petit ••!, focal
aotor seliocei, and occasional grand
aal first seen at 33 «k gestation.
Infant delifend at 39 «k.
01EGOI; DBOSSj DBOG TSBBiPT;
PUCBITI; ritos; BUI: nieofi;
IIFtlTS; lEOlOBOSCOUt DISUSES;
B100D; BLOOD SSBOB; UTICOITDLSilTS;
1ICI1TIOI; OBBILICtL COID
It birth, 6 be aftec 2SO aq dose
27-fc-old >OMn «ith petit ail, focal
aotoc seizures, and occasional grand
aal first seen at 33 «k gestation.
Infant delivered at 39 «k.
ciEGOi; noes; DBOG TRSUPT;
PllCRITi; FETUS; a ILK; IEIBOII;
IIFMTS; IBOBOflVSCOtM DISItiBS;
8IOCD: BLOOD SlIOR; HTICOItDlSalTS;
LlCTtTIOl; OBBXLXCal COEB
BEFEBHCt
Dickinson, B.s.
larland. I.e.
Lynn, B.It.
Snitb, B.
Gerber, 1.
1979
Dickinson, B.S.
Barland, B.C.
Lynn, R.K.
Saith, B.
Gerber. 1.
1979
OJ
-------
t«l«cle «cl4. 2-pcopyl-. «c«H«« salt (8 CZ)
r«BMnolc icld, 2-propfl-. •olloa ««lt (9 CI|
10(9-66-S
C8-B16-02.Ba
Bt 167.23
nssoB
3112
float.
BIFOSOBB BOOTB
Xngwotloi
-
IBalRXCal.
BBTBOO
-
GC
BOBBBB
OF C1SBS
6
BaBOB
-
369-89 uwolmm/l
-
8MB
Bot gi»»n
-
EEltBlL XBMBBHXOB
B»9* of Mau, 2 anfl 2* he aft«r
800-ig
-------
TaUconltril*. S-<(3.«-aU«tboirph«n«thTlta*thrlaiino) -2-(3,«--dlMthoxr-alpha-(1-»thrl«thyl> - (9 CIt
5J-53-9
CJ7-B38-I2-0*
II »5».59. BP 2»3-2«6 C at 0.01 •• Bg
TTSSOI
3113
Blood.
a*r«n
ZXPOSOB1 100TI
Injection
ingiatlon
tllLRICIL
BMBOD
rinoroa*trr
IDBBBB
or CISBS
6
BUGS
a) lot gt»«n
b) lot gif«n
REll
a) 170 ng/nl
b) 190 og/al
Gtimt IIFOBBtTIOR
a) P»ak IS tin attir 10-ag 1 reaction
(70 ng/nl at 1 hr and 20 ng/ll at 6
hrl
b) Peak 1.5 hr a(t« 120-ng oral dose
(30 ng/al at 0. 5 hr and 75 ng/ll at 8
hr)
Baalthj JapaiMie inbjecta ag«d 21-68
rr.
Bark«d prolongation of PO Interval on
•Icetrocardlograni, «a« proportional
to nr« !•»!
EBOOS; BLOOD SEB08; JIMI
SBFEBERCI!
Koik«, T.
Shiianara, K.
shodo, I.
Saito, B.
1979
-------
Talln*. 3-i«cc*pto-, D- (8 CD
D-TallU, 3-MC«pto- (9 CI|
SJ-67-5
CS-B11-I-O2-S
II 1*9.21, BP 198.5 C (D-fori)
IISSDI
311*
Blood,
«u«
3115
Blood,
pluaa
3116
Blood.
•hoi*
3117
OClM
BXPOSOBB lOOTI
IB9***10B
lag* it ion
Ingcitlon
Inanition
1 III. men
RttOD
BPLC
IPLC
BPLC
BPLC
,
BDBBB1
OF CIStS
a
6
6
6
BUOB
0.75-1.0 ig/1
2.7-1.1 mg/l
1.8-».2 mg/1
86-1360 my/1
mi
0.88 19/1
_
S.07 B9/1
3.15 ig/l
398 19/1
6BIBIIL XIFOIH1TXOI
-
8!S •• r«<«c«d tori. 750 ig/day
D-p«nlclll»ln«.
ll«a«*told ictkrlti* p*tl«ti.
PIlICtLLIBIIBj BBkSOIBBBIT BRB005(
CIHDi; BBBOBWOID IBIBSIIIS; DIOOS;
01 06 TBBB»t; BLOOD: BLOOD FUSU;
EITTBIOCITI9: OIXBtl BBTMOtRBS
33* ii codaeid ton IB BOB-pcot«in
fraction iftir 750 mq/ttj.
Ih«»atold ictbcltli piti«Bti
FtllCILLtBIIS; BBtSOBBBBBT BRBOOSj
ClllDt: BBBOIUOID UTBBXTXS; DB08S;
DBOO TBBBlPTi BLOOD] BLOOD PUSBt;
IBTTRIOCTTBSl OBIil; BBTiBOLTTSS
»0.3t «« r«die*d foci IB noo-prat»ln
{Motion «tt«r 750 >9/a*r-
Ikiuitoid irtkcltii p«tl«nt>
PBIICILMBXBB; BHSOBBBBIT 1RBODS;
OIIDl; BBBOB1TOXD IBTB1ITIS; DBUSSj
DBDO TBBI1PT) BUOD; BLOOD PIlSBtl
(BTTBBOCTTBSl OIXIIl BBT1BOLITBS
15. SS *• codioid foti IB non-prot«ln
fraction aft«r 750 if/dar.
Ikiuitold actkcltli patient*.
PIUCILLIBIH; BBaSOBBBBBT BRIODS;
CmOl; BBBOB1TOXD JBtBEITISj DtOflS;
DIDO TBBBtPTl BLOOD; BLOOD *USM|
IltlBIOCIIBSl OBIBIs BBTtBOLXTBS
BBFBBBICB
3a«tr«, B.
Bat*n«t«in, D. L.
1978
Sa*tn, I.
BlblBltoiB. D.L.
1978
Siotn, B.
BibraitoiB, D.L.
1978
Saitc*, B.
BibnitoiB, D.L.
1978
Ul
CO
••si
-------
•anadln.
700-«2-2
f
It! S0.9«1«. IIP 1917 C, BP 3000 C, TP 1 •• 89 at 2240 C. 10 u 89 at 2570 C
TISSOB
3118
B«ir
3119
laic
3120
KldB«r
SXPOSOII BOOTS
-
-
iitmiOL
RETIOD
U
BS
BS
IDBBEI
or casts
11
.
•1 126
b) 90
e) 71
d) 85
•1 77
f) 28
9) 179
h) 108
BafGB
Bot d*t*ctabl«-0.75 ppa
a) lot glTWi
b) lot glT«B
c) lot glT.n
4) lot gl»«n
•) lot gi»«n
f) lot glvwt
9) lot glra
k) lot glrm
•) lot gl*«n
b) lot gl».n
c) Bot gl*ra
(BIR
Bill
0.23 ppa
•1 0.20 B9/9
b) 0.2* «g/g
c| .10 09/9
4) .12 ag/g
•I .20 ag/g
f) .35 gg/g
9) .20 19/9
k) .37 «g/g
OVOaattlC IUB«
•I 2.87 pp. (21)
W 2.«S pp. (31)
e| 1.9C pp. (3*)
tlOB)
GBIEHl IIPOBIITIOI
Sctlp htlc
Conor, (co. 2 *ill.g«> of lilt.
IiaiCBB in tk* iBBionsa T«ccitori«>
0( T«B*XB«1..
BIIB; fBIBIOEU; RBT1LS; TliCB
ItBBEITSi 30DIOI: tLOBIIOBi SXLICOl;
CB10BIIE; POItSSIOBi SCilDIOt;
tITllXOBi TlliOIOR: CBI08I08; GOLD;
IIIOkllSB; IBOI; COBiLT; BICDL;
CCPPBB; IIIC; tlSEHC; SELIIIOB;
BIOBIBE; BDBIDIOBi STKOITIOS; SIlTEBi
IITIIOIT: lODIIBl CESIOR; BH10B:
tlllBHOS; CIIIHB: SaiMIOR; BBICOBT
.) Long iBl.Bd cklUna
b) Qa««n« cklldna
c) Bconi chlldcvD
d| long XBliBd BdBlt*
«) Q«.«nB aaglt.
() Bco.z Bdaltc
g| Bale cklldnn
k) P«Bal« eklUcoa
COCOlatlOB* BVttMB T BBd tk.
(elloclBgi dut, eoB.nity location.
xi. Udttloaal data.
Scalp kale, ctocaaitn. IB IT. ag*. <1
to 9T«at.c tkan 51 }c.
BITlLSi TB1CI BLIRIBTS; Bill 08;
BOIOIl CtDBIDB; CBBOBTOBt COFPE1;
IBOl; LBaO; IRBIDBl RllGtIESEl
IIICDBTl BlCltl; SUBIIOBs SILTEI;
III; TiHOIOB; IIIC: BUB; aCB;
ICOttSl CBIiDIEl! SIXi COBMUTtTB
B11UMIOBS] DOSTi SOILS; all
tOLtOTXOI; OIBtl 1BMS; 181 TOBI
a| lo rasal dls«a><
t) lc«t« c.aal f.llan.
c) CkcoBle carnal (allacca
Dry «t bail.
f«cc«Bt of ».pl«. vltk d»t«etabl.
l«i«l« 1* Indicated la pac«atkuM.
>«top«l» at OClt lo.pltal.
tBaCI BlIBBItS; BBTaLS; igtOfSXBS;
CILirOBBIi; nDIBTS; IITEBJ SflBBI;
OISUSUl BTPEBTEISIOIt SODIDB;
IOIUSXIB; CtlCIOB] PBOSPBOIDS)
BI6IBSIB8; CaDBXOBt SXK; COFPBI;
tllO; HOI; BMOlllSSl UOIXIOIl
SIIXCOI; TXTHTOB; COB III; EXCKB1;
BOlTBDniBi Hit CBBOBXOB; StBOITTOB!
B1BIOB; IXIIXOBI SIITBBI TlllDIOB:
10BOI
UrEIEICB
P«EkOBB, l.K.
Tolaadia, J.I.
Dl«n«>, a.
1977
Cccaaan, J.P.
Blnn.ci, T.I.
Bnagacncc, J.I.
Fink«toB, c.
1975
lBdcapca.lt, s.
ll»and«c. o.T.
GoBlck, B.C.
197.
I/I
LO
00
-------
Tuadlii
7atO-C2-2
f
ati SO.HI*. ir I»IT c. IF aooo c. n i •• 14 at 2290 c. 10 •• Bg «t 2570 c
(conzmiD)
TXSMB
3121
Urar
3122
L»g
3123
lung
312*
Lug
Birosm IOOTI
iBumcii
•moo
E3
BS
S3
KS
EDBBIB
OF casts
„
30
20
-
a) 129
b| 15
B1BBB
•1 lot gl*n
b) Bat gl»«n
e| Bat gl»«m
lot d«t«cttbll-90.« «g/g
a*j «t
Bat glT»B
•) 1.B-*.7 «g/g dcf »t
b) lot glr«n
(IEIT
an
•1 2.20 ppa (IS)
b| 1.T1 ppa (2S)
e| 1.C3 ppa (2C)
Bat gt*«
2.1 ig/100 g dcy «t
•1 3.2 ag/g dry «t
bl 0.8 ag/g Jcj >t
PUB)
«BI1»1 IBFOBBlnOB
•I Bo t*inl dlmm
b) tcmt* r*»l f«ll«n«
e) ChcoBte c«o«l f*llacu
Dry »t bull
Pvccwt of *upl*« «ttk d*t*ct>bl*
!•*•!• l« liaicttid U p*r«Bt)i«Mi.
I*t0p«l«« «t OCH BMpltal.
tllCB B1BBEB1SI BBtUS; kOMVSIBSi
ClLIfOBBttt HDIBT3! LITBB; SfLBBI;
DISI1SBS; BnBBTIBSIOBl SOOXM;
totustai) cuczaii tiaspiOBOsi
BlflBBSIOfll C1DBIOB; XXKl COIPBB;
L1ID; IBOBl IIBSIIUB; UaiXBOBi
SXLICOBl tlltBIOB; COBUT; BICUlj
BOLIBOBBORi 1XB; CBBOBIQBl SnOBTIOBj
BtllOB: IITBIOI; SUTBI; TlBlDKIBl
eoioi
sictloB* of laags froi labjacts vko
•id b««a bitomlnoai coal iln«r« for
23-SO yc.
BBTtLS; TB1C1 BLBBIBTS! aiaBIBOB:
CIBXOB: BMIllIDBl BOBOBl CBIOBXOB;
COfPBl! anitllOB; XBOB; 1UC|
BUBBSXaB] B1B81IBSB; IICIBLi
SXLXCOB; SXITEB; til: TntBIOB;
flBlDIBB; LOBOS; COIL; OBX1BC STMBS:
QOWTIJ IIIIULS
IiclaaM «pn« tad low«c lobw. «nd
lyiph Bo4«t of laBg. Idditicntl datt
BtBllBbl*.
ScctiOBi of lang< tea* >abj«ct« «»o
Vld DB«B bltBBlBOBt COBl llBBE* fOC
1J-50 yr In BBlalgk Cooaty, Hit
TlcgiBlB.
BBtUS; tl»Cl BLIBEBTS: COIL;
BIBTLIIOB; COBtlT; CB1OBXOBS COVPBB;
IIOI; LB4DI B10BBSXOB; BIBOIBBSBi
BXCEBL; TXTaBIOB; ttBtDXOB; HBC;
10103; COBPkUTITB BULOITIOES;
3ILICI; QOHTIj ITBPR 10DES; BBST
T IIOI lit
B) COBl »10«t«
t) Control"
SBCtlOBB Of l«nq« CrOB d«C«»«d COBl
*ln*C« BBd BOB-COBl BiBWI fCOB
BBl«lgh COBBty. IT.
BBTU.3; TBiCl BLIBBBTS; COtt; SILICI;
BHTllIOB; CBtOBIOB; COPPB1: XBOB;
IHD; a»0»BSIOB; IlBOIBBSB; BICKBL;
IXTkllOB; TlllDIOBs II 1C! lOBBSt
CORPtSkTtTB BflLDHIOIS; IBS1
IIIGIlIk
BITBESECB
XBdrBpEBllt, S.
llBZBBdBE. O.T.
Oenlek. B.C.
197*
CCBbl*. J.T.
(•BBBBt B.O.
Boloilcz. F.B.
Knott, s.J.
Boltl, J.I.
Corckl, C.B.
1967
(•BBBB, B.6.
Crabl*, J.T.
SBBllVOOd, l.f.
CaclbBcg, J.B.
1971
S«Mt, D. T.
croaB*, I.E.
crabl*, J.T.
Caclb«tg. J.B.
LaiBkirt, e.S.
197«
V£>
-------
fanadiaa
7MO-62-2
f
Itn 50.9*1*. HP 1917 C. BP 3000 C, »P 1 •> 19 «t 2290 C, 10 mm Rg at 2570 C
(COETIIOBD)
TISSUE
3125
Lang
3126
Lyaph
nod*
3127
••11
3128
Spl**n
EXPOSOBB BOOTE
aULTTICIL
RETROD
B3
IS
n
ES
IOIBE1
or caSBS
13*
1*
•1 SO
b| 50
C| 3*
d) 23
MICE
2. 1-».7 ag/g dry st
lot gl»*n
•) lot glT«n
b) lot giT*n
c) lot gi**n
d) lot givm
•I lot giY*n
b) lot giT*a
c) lot given
BB»I
3.3 ag/g dry nt
20.0 .g/100 g dry "»
•1 0.0* ag/g dry st
b) 0.07 ag/g dry it
c) 0. 12 ag/g Icy *t
d) 0. 10 ag/g dry »t
•1 1.6* pp. (1*1
bl 0.0 pps (OS)
e) 0.0 ppi (01)
CtltBH IlfOtdiTIOI
(•age of Mans. Addition*! data
(Ttllabl*.
Stctiou of longs fro* d«c«a*ed last
Virginia bitaainoaa coal alntcs.
IRtlS; TS1CI BLUNTS; COat; SILICa;
eHtiLius; cBBomaa; COPPBI; noi:
HID; RtSIBSIOl; lllOilBSI; nCKEL:
TIHII08; VallDIOH; ZIK; LOKS;
CCBPaltTITI CTalOtTIOIS; IBS1
TIBGIlIt
Pllaonary hilar lyaph nod** froa
subjects «ho kad b**n bitailnoas coal
ain«rs for 12-50 yc la lalclgk, l*st
Virginia.
BIT1LS; TBICI BLIRIRS; COkt;
BIIT1LIQR; COIaLT; cnoRXOI; CO»BI;
HOI; LIIO; BtoiBSIOl; BAIGallSB;
licnt; TITallOBi filaOIOR; nK;
loios; coBPaunn ETILOITIOIS;
SllICa; QOiBTS; 1TRPR IODSS; IBST
VXIQHIa
a) Pathacs
t) lota*cs
c) lal* t**nag«rs
d) r*aal* t**n*9*ca
talus also gi»*n foe Mdiaaa and
9*o**tric aaans.
50 Mlanaslan faalli**, a*aa ag« of
Cat bars, *6 yc, aothaca, »1 jr. *3
ail* cblldr«a. 12-2* yr and 39 faaal*
calldc*n. 12-2* yr.
CIICI08; SODXOR; laGIBSXOR; ILORIIHB;
SOLTOBi CHIOIIIB; TllaDIDRi
BitotnsE: coppBit taics BLEEERS;
HOOD PIBSSOBB; IB! OOIIBa; BBTUS;
BIILS
a) lo c*aal dlsaas*
b) teat* canal failaccs
c) Ckroaic r«**l fallac**
Dry «t basis
P*cc*nt of saapl** vita d*t*ctabl*
l*r*ls is indicated IB pac*Dth*s*s.
latopslss at OCLk lospltal.
TlaCI ELEIBKS; MTUSl UTOrSIBS;
CILXfOBlia; (IDINSi tlTBl; SPLBBI;
DZSBaSIS; I1PBTBISXOIS SODI08;
lotissioR; ciLcioi; PBOSPROIOS:
BkOIISIOl! CaOIXOBi tTIC; COVPII;
llaDi IBOli BtlOIIISE; IIORXIDI;
SXtXCOl] TIMIXOBl COBUT) IICKIL;
BOtTBDBIOIl Til; CRBORIOH; SnORIOBi
IIBIOI; tlTBIOB; SUTUt Til IDIOT:
B010I
1EFEBEIICE
Caclbarg, J.B.
Ccabl*. J-T.
Listlaca, L.P.
lords, R.B.
Holts, J.L.
Baa*c, P.
Bolonlci, r.B.
1971
Rcsnan, E.G.
crabl*, J.T.
saallnood, ».«.
Caclbccg, J.B.
1971
lasironi, H.
Kolrtyonann, S.B.
Place*, J.o.
Scbassckala, B.C.
197C
Indcapcaslt, s.
ll*xand*c. o.».
Gonlck. B.C.
197*
Ol
*-
o
-------
fltulo t
11103-S7-*
coarosmoi onion 01 OIDRIIBTIBD
TI350B
3129
Blood.
MCU
3130
Blood,
MCM
BXPOSOU BOOM
lagoatloa
lllLTTIClt
BETBOD
•••Id e p«ar>OB
101 BBS
OF C1SBS
187
11
IttGE
a) lot gl*«B
b) lot gltra
•1 lot glvon
b) lot gl*«
-
HEtl
a) SO ag/100 ml
b) «8 09/100 al
a) 90 acg t
b) MO acg«
dBIIBlL IROIBITXOI
a) fl«n
b) IOMB
Criteria toe lo« !•»!• < 20 ag/100
al.
local otahna, 58 a*B, 129 noaan, aaaa
ag« C9 yc.
DIETS: TI1CB BLEBEITSi CBOLBSTEULS)
B100D SBBOIl KIC) COPPBBi PCTtSSIOB:
SODIOB; IISIBSIOB; CILCIDB; IBOI;
TITaBXI at flTalllS
.. -
a) M(or« TitailB 1
b) 7 kc aftac 300,000 I.o. Tltaala
l-palaltat* |p«ak|
falMa ••tiiatvd troa gxapk
lk«a Tttaalo It >a« gl««> «itb vtrioa*
di«t«cj fllwc praparatioa* a«caa
1«T«1« agaalvd oc «o««d«d ccatcol
laralB.
Baaltky 19-22 yc old*.
t ITIBIIS ; Titian t; BLOOD snaa;
IIIaBOLISlI PIBBBS: DIBTS;
COBPiHTITB ETHDHIOIS; OE1B1IT
KPBUICB
Bcndrlck*. D.G.
Bahoaty, l.v.
1978
(a*p*r, B.
labaat, 0.
1979
-------
line
100-66-6
II
Itl 65.38, IP «19.5 C. BP 90S C, It 1 » Ig it IB7 C. 10 •• Rg it 590 C
nssvt
3131
adlpOII
3132
lorti
3133
Blood
313*
Blood
IIKSDII IOOTI
I ULTTXCal
BITIOD
_ _. - ---
X-riy spictroi
I-ray cpoctroi
US
,. ,
IOBBBB
or GIBBS
•
9
72
MIDI
lot glTsn
lot glm
•) lot gl»ii
b) lot gl»«n
c) lot glfon
11 lot gl*«n
•) lot gl»«n
f) lot giT«n
nil
1.29 ppi dry «t
SB. 2 ppi dry it
a) <« tg/100 il
b) 62 ig/100 •!
e) (2 19/100 •!
4| 105 ng/100 ml
•) 103 ug/100 •!
f) 100 ag/100 ml
OZIIIIL IITOIHTIOI
Itdailntl fit. 2 nipl«* p«i cu*.
2 inilym p«r »ipl«.
197* aitopiiu of 10 ?!•« InUiu. •
fipigo, and i Cc**k Indian.
tOTaSSIOBi C1LCIOH; HOI; COIPBI;
SIK; IUBIDIOB; IICHL; LlaOl BRltSt
TliCE n.BIIITS; UfBB; SPLIBI; I01TII
IIOIBI3; IDinSB TISSOI; PllCIIkS;
BttSOBBHBIT IRBODS; KJTOPSIIS '
2 caipl** ptr c»«. 2 analyMi p*r
•iipl*.
197* aatopilM of 10 tin Indians. •
Capigo, and • Crock Indlu.
tOHSSIOB; C1LCIDB; HOI; COfpBI;
IIIC; BaBIDIOB; nCKEl; LBlOj BIXaLS:
II1CB BLBBBITS] LXfBI; SPLIII; 1O1T1;
HDIBTSt 1BIIOSB TISSUE; PMCIBUt
BltSOIBBBIT IRIODSl aOTOPSIIS
•) Blood fcoi 22 icthois. loi birth
•t groip (1500-2500 g)
t) Blood fro* 50 ictnirs, nonil
birth it gcoip (>2500 g)
e) Blood ttoi 22 iota«». nonal
blrta «t gteip iitchod «lth lo» birth
•t groip for MI, iitonil igo, rico«
••oklig kablts, (arlty
d) Cord blood froi 22 aothcr*. Ion
blrti «t groip
•t Cord blood froi SO lothcri, oorial
blrta it groip
f) cord blood froi 22 Mthiri. oorul
birth it groip iitehod ilth Ion birth
•t groip for ••», iiuraal igi, rac*,
iioklig habits, (a city.
Bothers iho «a»« birth In •••rk, IJ,
Iprll-Siptcibsr, 1975.
•itusi CU.CXOBI cmoaioBi CCPIHJ
IlOlt BIOIISIOB; inCl BlOODl i DOITS I
IRIS; in jnsm coipiutxn
ITILOaflOIS
IITllW
iRusi coppn; noi; uansnai
iiiaiiisit UK; IRUIOPIOTHISI
BINBtTOID tltlBZTZS; BlflBt
IBPIIBICB
lugilsoi, l.F.
Rill, R.I.
llolsoi, (.(.
Bltoigh, D.J.
ChrlstoiMi, J.J.
Ixatt, B.B.
llchudi, D.O.
1979
augilson, I.P.
Bill, I.I.
llolSOB, U.K.
Kitoigh, D.J.
ChrlitciMi. J.J.
loatt, i.i.
Richards, D.O.
1979
Bogdu, J.D.
Thlld, I.S.
Klip, P.I.
Citirlil, I.
197B
Sorauoi, J.l.J.
1*78
1
Ul
4S
N>
(IBR PIOB)
-------
lllC
7MO-66-6
It! 65.38, at (19.5 C, BP 906 C, TP 1 •• Ig «t 187 C. 10 II Eg «t 540 C
(CORIIOBD)
tissot
3135
Blood
3136
Blood
3137
Blood
3138
Blood,
cell*
-
BXPOSQIB tOOIB
.
•
1I1LTTXC1I.
BHBOD
US
»
US
MS
IOIBBI
OP C1SBS
•I 29
b| 19
C) 17
d| 5*
•1 37
O 17
91 3«
h| 38
H 7
Jl »
•I 70*
b) «67
16
--
•5
UMB
•1 3.13-1.89 ft*
bl 3.36-7.11 ppi
c) 3.1-5.7 ft*
d) 2.0-9.7 ppi
•) 2.5-9.1 ft*
ft 3.9-7.6 pp*
2) 2.9-6.0 ppi
) 2.0-9.1 ppi
i) 3.3-5.4 ppi
j| 3.2-5.2 ppi
•I lot 9l»«n
b) lot gltm
•) BOt glTra
b) lot glvu
e) lot gl*on
•) lot glvm
b) lot gltu
c) lot glvu
d) lot gl*«n
•) lot glrn
f| lot glVM
gt lot glT«i
b) lot givm
(IIR
nti
•) «.S1 ppi
b) 5.25 ppi
e) «. ppi
d) «. ppi
•1 «. PPi
f) 5. ppi
g) •• ppi
h) «. ppi
1) •• PPi
1} «.3 PPi
•) 36.5 » or - 7.9
ig/g
b) 1*.9 » or - a.«
ag/g
•) 82 » ot - 9 ag/100
•1
ta) 66 » or - 7 ag/100
•1
el 16 » or - 3 ag/100
•1
*> 39.8 • or - «.3
ag/glb
b) 107.7 » ot - 19.3
•g/10(l*10) c«ll«
e) 50.7 » or - 7.2
ag/g«b
d| 66.* » or - 8.2
ag/10(l*10| eilli
•I 5*. 6 » ot - «.2
ag/glb
n 74.3 » or - 10.8
ag/10(l*10) calls
g) *8.2 » or - 5.6
ag/glb
k) 70.7 » ot - 11.6
ag/10(l»10| colli
Plan
CEIIItL IBPOBIkTXOI
•1 0-3 yc-old hoipital patlaitl
b| (-6 yc-old koipitil paticati
c) Illldtntl < 1 ki froi 2 ki froi noltoc, 2-3
1*
f) igo 2-3 Ji, blood Pb < 100 ppb
g) kg* 2-3 yc. blood Pb 101-150 ppb
k| kgo 2-3 yc. blood Pb 151-200 ppb
1) kg* 2-3 yc. blood Pb 201-250 ppb
j) tgi 2-3 yc. blood Pb > 25C ppb
Ditch mbj«ct« tgid 2 10 oc cldic.
IttUSi CkOBIOl; COPPBI; ItOl; IBID;
BkiaklBSB] IXKl BIOODl BlOOt SBIOI:
3BOUIO; Olkt COITUCBPtlTIS;
IIDOST1IBS; 3IBLTII3: 4DOLIS:
CltLDlBII SBIl IRIlUklDS
•) HtWBll
b) Petal
Dry it bull
Saiploi froi • hoipltali In
luh*ill*. Tl.
tlkCIRk] BBTilSj HkCB BUI NTS;
TIIIUSIB] BIOODJ Bklki COBPIBitlTB
IfkLOkTlalS; IBICOIli IBkD; CIDBUJB;
SILHiaii IDBIDIOI; 1801 1 tlK;
COBUT
•1 total ME»
b) klbaaln-boud
c) klpha nb 2 laccoglaballn-boand
B«llthy (utid Mill, 23 to 49 yr of
•g*.
IIKt BBT1LS: PlklCli IlkSOiniR
BIIBODS] BIOODl IIWIXISl BIIBBU.S;
ItTkBOlISB
I) Control!. «gu 28-60 yc
b) Co* t coll, agu 28-60 yc
e| liiodlilyMd patlinti, aga 38-6*
d) BiiodlalyMd p* tints. *g«i 38-6*
yi
•1 Mcltonial dlalyiid pitlnti, ign
M-65 yc
() McitOMil dlalynd p«tl«Btl, «gn
i»-65 yc
gl loadlalyud pitiiiti. ag«i 36-56
2*
1 loidlilynd patliati. *g«i 36-58
ft
•1. e|. •), ud g) «• •tythcooytci,
b| . d) , f ) . ud h) it* liacocytei.
lattmti differ fcoi aoatcoli. P
<0.001. •) ud b) 20 CIMI, c) ud
d) 10. i| and f) 5. g) ud h) 10
Pitliati ilth ehtoiie nnal fallu*.
tZIC| inklS) BIIBI1L intBOUSB)
BIOOD PikSBkl IBITIBOCRIS;
IinOCITBI) Bkll« DISIkSBS; IDOITS)
CCBPklkHfl IflLOkTIOISl kllClIk
BBTEBBBCB
ZillhliS. B.L.
del Caltilho, P.
•Kbit. I.P.B.
llbovo, 1.1.8.
1978
Biglan, B.J.
Bcul, k.B.
Schalict. 1.
Illion, D.
L*ci», K.
Dy«c, 1.
nanioic, B.
Schaffaic. 1.
Saffian, t.
Da*l«i, J.
197*
aicooz, B.L.
1975
Bahajan, S.I.
Pcaiad, k.S.
labbul, p.
Btlggi. I.I.
IcDonald. P.O.
1979
in
•is
U)
-------
line
•JMO-68-6
SI
It! 65.38, BS »19.S C. BP 906 C, T? 1 •• 19 at »87 c. 10 ae 89 »t 590 C
(COBTItVBDI
TT3SOB
3139
Blood.
plasaa
31*0
Blood.
plasaa
Blood,
plasaa
BIPOSOBB BOOTS
Itgestlon
ABlLTTICkl
IBTBOD
us
us
us
IDIBBB
or ctsBS
1*5
2
BlIGE
0.85-0.90 ppa
lange of aaans
.
a| lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
.
•0-119 ag/dl
(HIT
RBll
0.87 ppa
a) 31 ag/100 nl
b) 190 ag/100 al
e) 15 ag/100 al
d) 1«7 ag/100 nl
7» » or - 12 ag/dl
Ptai)
GBIIBll ISFOBRlTIOl
Idditlonil data available.
tealthy adalts not Casting, igad 19
to 51 yc, froa Smden.
BIM15: SIIC; COPPEB; BLOOD; BLOOD
PUSBl: SlLIf!; DBIglBK; SIX; IDOLTS
.
•) Patient 1, after 9 ao of diarrhea
and 6 vk of parenteral allaentation.
before Sn therapy
b) Patient 1 after oral Zn. 35
sg/day, 10 days
c) Patieat 2. after 6 so of diarrhea
and 5 »k of parenteral aliaentation,
before Sa therapy, d) Patient 2,
after oral Sn. 35 ng/day, 10 days
T«o infants treated ilth parentezal
allnentation for intractable
diarrhea.
22-25 days after start of pareateral
aliaentatlon patients becasa
feverish. Bash of erythesa,
vesicles, denuded patches, and
pastalas developed aroand nataral
orifices, gesltalia. perinea a,
fingers, and toes, alopecia,
blepharitis, and paronychia. Bash
and fever responded to oral line.
Striking decrease in sernn alkaline
fkosphatase. leponded to oral sine.
IIICJ BLOOD PlaSBl! COPPBB) 9EII
DISI1SBS! RET.1LS
58 tests condected after an cvemight
fast, also data on changes la plossa
ta «hen dose ingested «ith
traditional diet, laFeBDTl. cc
la2EDTl. bat absolate valaes not
given.
Idalt volonteers living in Ooateaala,
in apparent good health, fasted
overnight.
IIIC; IBTUSl DIETS] QOITBHUS
IEBLTS; COBPIBITITB EmOlTICIS;
HOOD pLtssi
BBFBBBICB
Ratbor, i.
•alien las, K.
Ibdalla. R.
1977
irakava, T.
Taanra, T.
Igarashi. I.
Sasaki, B.
Sandstead, B.B.
1976
Solosons. I.I.
Jacob, B. 1.
Pineda, o.
Uteri, r.B.
19T9
-------
Sloe
7MO-66-6
I>
iti K.3*. ii «i9.s c. ar 90e c, ?r i aa ag at «IT c. 10 •• ig at 590 c
(COITIfOBD)
TiBSDB
31*2
Blood.
plaaaa
31*3
Blood,
plaaaa
31M
Mood.
pl»»
—————
inosmi Man
lageatlon
Ing* at ion
IIURXCal
•moo
BS
US
us
im an
or cists
-
•I »•
bl 29
•I 56
b) 22
c) 8
d| 12
•1 27
bl 72
c) 7
d| 3»
UIQE
•I lot glfaa
b| tot giTea
•1 71-126 09/100 ml
b) »2-126 ig/100 ml
c) 31-82 oa/100 il
4) 32-80 09/100 al
•1 It-ISO 09/100 ml
b) 52-120 09/100 ml
cl 52-91 09/100 ml
d) 50-168 09/100 •!
(HIT
rati
a) 81.9 * or - 2.2
ag/100 ml
b) 76.5 * oc - 2.2
09/100 il
•I 99 07/100 ml
b) 86 09/100 ml
c) 57 09/100 ml
4| 57 09/100 •!
t) 78.5 09/100 ml
b| 77.3 og/100 ml
c) 72.3 og/100 •!
d) ««.« og/100 ml
pass)
BIIB1IL IirOlBlTIOl
•I Boja. baaa-llna *I!M
b| slcU, bt*«-lla« T»lo«
Boy*1 1«T«1> klgh*c tku girl*'
|«0.05)
50* of ckildnn (ecntcol) E«o*lT*d
non-la foctlfUd c«n«l aaa SO*
(tastl nc«l««d Certified evcaal
•blch provided 2.57 utca ag la fmc
d«y. lft«r 9 ao, teat child an had
6.4 ag/ai aon plaaaa In thaa
controla (P<0.05|.
••altar ckildnn 33-90 ao old (aaaa
«9« 57.9 ao). fcoa ilddl* iacoaa
(aalllaa. aacollal in private
pruckool and klalavgactoa in 0«a»«r,
1975.
BRUSi TB»CB BLBBBITS; XIBCj
CCIHIaTXTB IfitOJTIOBS; B1OCD
FIlSBl; ikll; StLITa; OBIII;
CBXLDRBIi SBI; DXB1S; COLOItCO
a) Raaltky controls
t| Bacaaaaa patlanta
c| Racuaic kvaabiorkoc patiata
dl (naakloikor patlanta
Bicapt for aoraal tang* all ralora
•atlaat«d froa grafka
In lanla calatad to lndi»idwl
clinical (aataraa of aataca
aalnotrltion.
Controla- 16 noraal Jaaaicaa children
i-20 ao oil attaaaing ««ll-babT
clinic and «0 adolt ataff aaibara,
Oalraraiti Boapital of tka laat
xadlaa. RalnoarlakaA childrvc-
Jaaaicana, >-21 ao old "h«n
hcapltallzad.
In aalnoorlakad cklldcan, loi plaaaa
in concentration atronglT aaaociatad
ulth praaanc* of notrltlonal adaaa.
la abaanca of adaaa, aignlficant
ralatlonahipa batvaen plaaaa tn
concantratlona and atnntlng, akin
alcaration. and naatlng.
8RILS; TBtCE ElBRBBTS; II»C;
COBPkltTKB mLOlTXOBS; CBXIOin;
IOTUTIOHL DBPICIIBCIBS; KUBITIOIIL
CISOBDBBS; BLOOD PlaSBa; JkBIXCl
a) lalaa. 65-91 jt old. vlthcat
*itaain aopplaaant
t) Faaalaa, 65-95 ji old, without
litaain aapplaaant
c) Balaa. 66-78 jt old. «ith
aaltlTltaala aapplaaant
d) Faaalaa. 67-93 ji old. >ith
aoltldtaaln aapplaaant
IGI; BLOOD; BUB: UBHID; BITALS;
T11CB (LBBBItS; »IT»BI«S
UTIBJICI
laabidga, K.B.
Cka*as, B.I.
Bcoaa, I.B.
lalravma, P.I.
1979
Goldan. B.I.
eoldaa, I.B.I.
1979
Ln
Tir, s.c.
Lon. l.B.G.
1979
-------
11*0
7MO-66-6
!•
ttl 65.3S. If »19.S c. BP 908 C, TV 1 •• Bg at »87 c. 10 •• Ig at 590 C
(COITIIOID)
nssoB
31B5
Blood.
plan*
3U6
Blood,
plain
31*7
Blood.
••CD!
31*8
Blood.
•erai
31*9
BlooA.
••Ell
inOSVU 100TI
IBURICU
BSTBOD
US
us
us
us
ioiBil —
or CUBS
a) 20
M 10
el S
A) 10
a) C
b) 12
c) 16
A) 20
•1 10
O 9
9) «
h) 22
a) S
b) S
35
umi
a) lot given
b) lot given
c) tot glT«
A) lot given
a) .72-1.05 ag/il
b) .39-1.18 ag/ll
e) .52-1.31 ag/ll
A) .39-1.05 ig/il
•) .72-1.18 ag/ll
f| .59-1.18 ig/ll
g) .67-1.11 ag/ll
h) .76-1.13 ig/il
'•
a) 32.0-62.8 ug/Al
b) 30.8-78.2 09/41
a) lot given
b) lot given
c) lot given
A) lot glT«n
mi
a) 112.9 » oc - 13. C
«»/Al
b) 78.6 » or - 6.6
ag/dl
c) 82.8 » or - 1.6
og/Al
A) 8*. 8 * oc - 2.8
ig/Al
a) 0.817 ag/il
b) 0.790 ag/il
c| 0.817 ag/il
A) 0.768 ag/il
•) 0.916 ag/il
O 0.850 ig/il
g) 0.905 ag/il
h) 0.966 ag/ll
a) «*.9 og/Al
b) 63.5 vg/Al
a) 729 ig/l
b) 351 09/1
c) 7*8 og/1
A) 1038 og/1
giiiiii iiroiRiiioi
a) Controls, normal aubjecta, ag*i
28-60 re
b| gmoAlaly««A patlotc. aga 38-6*
IE
c) MrltoMal Aial]n«A pattcnti, *q««
I*-K'5 TT
Al loaAlalytiA patimti, ag«i 36-58
jr
Iatl«Bt« Ai((«r froi coat coll,
K0.001.
tati«it> »itb chronic nntl talloi*.
IIIC; IR»1S; BIIIIU BBT1BOIISB;
B100D PLISBii BITTHBOCmSl
LlreOCIIBS; UIB; BISBlSBSl IDOITSt
CCmilTIVB I»LOaIXOISi IBBCIU
a) 5-<10 jt old ial«i
b) 5-<10 yr old f«Ml««
e| 10-<15 re old lalaa
d) 10-<15 yr old faialo*
•) 60* yc old ••!••
f) 60* yc old fvialu
g) caaeaiiana. controls 11-17 yr olA
••!••
k) caacaiiana, 11-17 yr olA (nalca
IbodglMi, 5-77 yr old, froi
loiaijn rlttroy crasilag conanitlM
of I.I. laitrilia. aid41«-claaa
caocailaa chllAna ai control*.
BIOOD SBIOBl BIOOD niSBll SIIC)
CCPFBB; HOI; IITklSj kOSTBlUl;
HITS: tai: CHLOSIBI IDOLTS
a) IOMI taking a coibiaatloa oral
eoatraecptl**. >ft«r 35 Aays on Aiit
b) IOMI lot taking a contraceptive.
aftar 35 Aayi on Aiit
Dlat contained no In, Co, F«, bat •««
ctk«r«la« nitritionally adegnte.
Soaa aabjacta: diarrhea, aore
tkroat, itoiatltii apktkoae.
iiic; coppiii BBTtis; inioeni BIOOD
SEBOB; Ollt COITItCBPTinS: nOTEHS;
BITIBOLISB
a) Day 1
b) Day 2
c) Day 10
d) Day 20
35 barn cam, 15-61 yr. Average of
3IS of body aarfact burnt.
IIK; COPPHI: BtOOC SBIOB
liTlen
BtoiEstoH; tuoi incj aniLE; TBICB
IIEIBRS; DIIIKII6 IHBI; BLOOD;
BIOOD SBBOB; HBUI; BO BBS; OBITED
B.IBQDOB; CtBlDl; DIITED SHTIS;
FIBLIBD
BirilEICB
Bahajan, s.B.
praaaA, t.s.
Babbani, P.
Briggs, l.t.
BcDonald, f.D.
1979
Bolt, i.a.
Spargo, I.B.
Iveion, J.B.
raalkner, O.S.
Cheek, D.B.
19BO
Bess, F.B.
King, J.C.
Bargen, S.
1977,
laFargne, P.
coatnre, J.C.
Bontell. 1.
Gailbaad, J.
Salioa, L.
1976
sbarrett, I.B.
1977
-------
sloe
7MO-66-6
l« 65.38. It ai9.S C. BP 901 C, fP 1 u Ig at «87 C, 10 •• Ig at 590 C
(COItXIOSD)
TISSOI
3150
Blood,
seroa
3151
Blood.
aerus
3152
Blood.
•eras
3153
Blood,
seres
...
mason MOTB
Inge at ion
Xngestion
Ingestion
lltLRXCal
RETROD
US
US
us
us
IDHBBB
OF CIStS
187
a) 16
b) 16
cj 9
a) 59
b) 8
62
UIQI
a) lot given
b) tot given
a) 99-280 eg/11
b) 5«-98 eg/41
c) 89-123 sg/dl
a| sot given
b) lot given
a) lot given
b) lot given
(•BIT
nil
a) 118 ag/100 si
b) 107 ag/100 si
a) lot applicable
b) lot applicable
e) lot applicable
a) 77 » or - ag/100
al
b) 86 » or - 10
ag/100 al
a) 83 » or - 23
ag/100 el
b| 83 • or - 37
ag/100 el
PIOSI
BtlBHL XirOIBMXOI
a) Hen
b| losen
Criteria for loa levels < 81 ag/100
al.
laral Otahna, SB aea. 129 «osan, aean
age 69 yr.
DIETS; fllCI HEBEtTS; CROLBSTIIOLS;
BIOOD SBBOB; II 1C; COPPBI; POTaSSXOR;
SODXOR; HIQIISIOB; CiLCIOB: IBOI;
fXHIXI a| TXTaBXIS
a) Control, 0 and 2 hr after 50 eg
la. Plaal valae. US ig/41 at 6 hr
b| clrrhotlc. 0 and 2 hr after 50 ag
IB. FlBBl valae, 54 ag/dl at 6 hr
c) Postsargical group, 0 and 2 hr
after SO eg SB. Final valae, 90
ag/dl at 6 hr
111 groaps fasted before In.
Controls, patisnts "1th alcoholic
cirrhosis, surgical patient! vlth
delnyed healing.
tXIC; CIBBBOSIS; Oil II; BLOOC;
HtllSH; IIST TIBGtnt; SOBSBBI;
CILCIOH: RI8IBSXOR; COPPBB; TBICB
HBJIITS; DIOBS; RBT1LS: 1XVD!
CISItSIS
a) Sobjacta in sarvey - dietary
Intake of 9.8 • or - 3.6 eg/day
daterained by dietary recall
b) Subjects in setabolic atady - 11.6
• or - 4. 3 eg/day included in diet
13.5-14.6 yr old girls participating
la either a 30 day aetabolic study or
a nutrition sarvey.
HRU.3; TilCt ItlRBRSt HXIBUIS;
ZXIC; S1LITI) BLOOE SBBDH; BUB;
CCIPtllTIVt ETlLOmOIS; tDOUSCBITS;
CUTS; IBTI80LISI; XIDIIH
•1 First or second trlaeater
t) Third trlaeater (30 coaplated
atadyl
Sabeaaple of 34* «oaen vhose daily Zn
Intake ••» 1-29 eg, based on 2*-hr
dietary recall. 2< or less on dleta
that aet or exceeded lecoaaeided
Dietary Illovaaca. lo signl (leant
correlation between low intakes and
lo» seraa levele daring pregnancy.
Pregnant lon-lncoaa >oaen of lexican
daaceat. 15-40 yr old, who attended 2
lea tngelea County prenatal clinics
H72-1974.
Coring 3rd trlnester heaoglorln and
-------
7MO-66-S
Si
Itl 65.38, It »19.5 C. 8» tOt C, n 1 u 19 at «B7 C, 10 • • If at 590 C
(comniD)
nssoi
315*
•load.
3155
Hood.
aaraa
3156
Blood.
•araa
3157
Blood.
•a EBB
3158
Blood.
•kola
IIMSIII tOOTI
Ingaatloa
Injaction
IIILTTICIL
1ITBOD
US
us
us
us
-
us
101 BIB
or cists
a
2*
at 15
M 10
c| 12
d) 7
at «2
ft 36
.
19
1*5
UMI
297. a-3 17.0 ag/100 al
a) lot glvan
b) lot gl»aa
c) lot gi»aa
d) lot 9l*an
a) lot glvaa
f) lot gltaa
at .55-0.93 ag/al
b) .60-1.18 ag/al
c) .60-0.95 ag/al
d) .65-0.80 B9/B1
a) .50-1.30 og/al
ft .56-1.22 ag/al
a) 36-1*0 ag/dl
b) 30-130 ag/dl
5.91-6.78 ppa
langa of aaana
(••IT
iiii
lot glfaa
at 1.7 ag/al
b) 2.3 aj/al
et 2.2 ag/al
d) 1.* ag/al
a) 1.5 og/al
ft 2.2 ag/al
•1 0.73* ag/al
b) 0.791 ag/al
e) 0.725 ig/al
4) 0.709 ag/al
a) 0.959 ag/al
ft 0.871 ag/al
at 88 » OE - 7 ag/dl
b) «6 » or - 6 ag/dl
(SI)
6.*1 ppa
HOI)
atiiiii tipoiBinoi
lain valaaa all gcoapa daring *
aiparlaaatal parloda of * daja aack.
Sibjacta raeaivad 10.99 (10.52-11.16)
ag In/d*r altb baaal 4iat or »lth
taaal 4iat plaa 1*.2 9/dar aapplaaant
callaloaa, kaalcallaloaa or faetla.
Saall ekangaa la aaraa contact or
•rlnarr aicration daa to astca flbar.
•ignlfleaat ckangaa la facal ainaral
Baaltkr adolaacaat bora
IKILSt TIICI BLIIIBTSt IIIIIUS;
COPPII; SIIC; BlOIBSIOBl BLOCD SBIOI)
OIIII] riCIS; 1DOLISCBITS; FIBItS;
COBPII4TXVI ITlLOltlOIS! IIBUSU
a) 1-3 ao lactation
b) «-« ao lactation
c) 7-9 ao lactation
4) 10-15 ao lactation
a) 16-21 ao lactation
f) 22-31 ao lactation
Ikita coaaa, 1-31 ao poatpartaa.
BLOOD SIIOB; BILK; Bill; IBTILS;
I4CT4TIOI; CILCIOB; BISIBSIOI;
B4S04IISI; IIOI; CCPni; SIIC
a) 5-<10 rr. aalaa
b) 5-<10 rr, faaalaa
c) 10-<15 rE. aalaa
d) 10-<1S rr, faaalaa
a) 20-60 re, aalaa
f) 20-60 re. faaalaa
Iboriginaa froa aonaajoa.
Bipoilncaaia >SOI In 5-15 jr olda.
Iboriginaa, 5-CO rr old froa loaanjaa
and Pltiror Croaalag coaaanltiaa of
I.I. loatralla.
BIOOD SB10B; BLOOD PL4SB4; XIIC;
CCPPBI; IIOI; aRklS; 10ST141I4;
CISTS; 401; CBILDIII; 4DOLTS
at Pro-total parantaral notrition
b) Daring total parantaral nutrition
(5-*2 4ara)
tine contaat of hrparallaantition
tlald ««• 200-800 ag/1. Baana In a)
and b) dlffarant, K0.01.
Cancar patiaata, agaa 12-63 IT. aaan
•t loaa of 18.9 » or - 3.2* froa
pra-lllnaaa Might.
SIIC; COPPSI; IBT4IS; HIBUl
imaoLisi; BLOOD snoat oun;
HOPLkSIS; DIBTS
laaalaa bad algalflcaatlr loaar la»al
tkan aalaa (P<0.001|. additional
data atallabla.
laalthr adalta not faatlng, agad 19
to 51 TE. tEoa saadaa.
IC»LS; SIIC; COPPSI; BLOOD; BLOOD
tllSBt; S1LITI; DliaUI; SIX; I DOLTS
DTI IIICS
OEBM, L. 1.
Klaa, C.
rox, i.i.
1979
Taagkan, L.4.
•abar, C.I.
Kaabarling, S.I.
1979
Bolt. 4.B.
Spargo, I.B.
Ivaaoa, J.B.
Faolknar. G.S.
caaak, O.B.
1980
Lourr, s.P.
Goodgaaa. J.T.
Salth, J.C.
lakar, B.B.
Bakack, B.I.
RaaklB. I.I.
Bcaanaa, a. p.
1979
Bathar, ».
lallanloa, K.
tbdalla, a.
1977
Ul
*»
00
-------
SUe
TWO-W-6
att 65.3*. it »19.5 c, BP *oa c. n i as 19 «t «ST c. 10 •• 19 at 590 c
(CORIIOBD)
TI33DI
3159
Bair
3160
Heir
3161
Hair
3162
laic
ixrosrai IOIRB
Ingestlon
II1LTTIC1L
HRBOD
H
us
.--
US
us
IOBBII
OP CUBS
11
3
a) 179
bl 108
•1 59
b| 8
It KB
1S5-«6S ft*
,....
a) 0.3-2.0 ag/aa
b) 0.2-1. a ng/aa
c) 0.13-0.75 ng/ea
a) lot given
b) lot gi»en
•I lot given
b) lot glvm
(KIT
nil
308 ppa
a) lot given
b) lot given
e) lot given
•) 83.9 «g/g
b) 101.1 ng/g
Geoaetrlc ••»•
•1 183 » or - »7 «g/g
b) 182 » or - 50 «9/g
FtOK)
CEIIUL uroiatTioi
Sctlp k«lc
Doaon tfom 2 Tlllagu at ftik*
Indlau IB tk« *HSOU« T«cciton««
Of f«D«It*ll.
Bin; THBIOBU; BRU.S: tlici
IIMBITS; SODXOBi 11081108: SILtCOl;
CBIOIIIB; rOUSSIOBi SCtlDIOBt
1XTIIZOI; T1MOXOB; CBBOBIOBt BOLD;
giMtlBSB: XMI; C08UI; BXCIBtt
COfPBB; (IICi IBSBIXC; SBLBBIOBl
aiOIIIB; BOBXDIOBi SnORIOB; SII.VBB;
iitxioiT: xoDiiB; CBSXOB: BIBXDB;
lllTBliai; CBIX08; SmSIOUj BBBCOBT
•) Stbjcct 1. graying bcona taic
b) sabj«ct 2. dark bcom hate
e| Sobjact 3, bl*ach*d bco«n hair
lang* l» rang* of *aln«« along Ivagth
ef a hair. laln«« (coa graph*.
t«ai4«Bt« of Tancoa<«c, British
Colaabia, ag«d »3, 25 and 29 yc-
IIIC; 8BTaLS; Han : ClUOa
a) Hal* children
t| f«aal« childraa
Correlation t«t«««n zn and ««.
tadltloaal data.
Scalp hair, Caicaaiana in III, age* <1
to greater than 51 yr.
IBtaLS; TB1CI BLBIBITS; BaBIOR;
BCBOIl CaOaiOB; CBIOBIOI; CORBB;
HOIS LMD; tXTRXOBl I1IB1IBSB:
B1BCOBT; IXCREll SBLBIIDB; SH.TBB;
TIlS TtlaDIOBi XXICS BHBj ICE;
1 DOITS; CHItDlBI; SBX; COBIalaTITB
BVILOITIOIS; DUST; SOUS; til
F01LOTIOI; QIB1I 1SB1S; IB* TOBK
a) Sub)*cta in sarvey - dietary
intake of 9.8 • or - 3.6 eg/day
deterained by dietacy recall
b| Subjects in aetabolic study - 11.8
» or - «. 3 ag/day ineladed in diet
13.5-11.6 yt old girls participating
in either a 30 day aetabolic study or
a nutrition svrvey.
atTILS; T1ICB BIBHBITS; BI1BHLS;
IIIC; SILITl; B10OD SBBOB{ IIXB;
CCBPIBITUB BftLOaTIOIS; aDOIBSCBITS;
CUTS; aiTiaoLisii XIDIIII
IBFEtBICB
Perkons, a. K.
Telandla, J.I.
Dienes. B.
1977
aau, D.
Pate. B.D.
1977
Creason, J.t.
B Inner a, T.I.
Bnagarner, J.E.
Pinkerton. C.
1975
Greger, J.L.
Sickles. T.s.
1979
vo
-------
Cine
7MO-66-6
in
ktl 65.38, BP «19.5 C, SP 908 C. fP 1 in Rg at *87 C, 10 a* Bg at 590 C
(COITIIOED)
TISSUE
3163
aair
316*
lair
3165
Balr
3166
Balr
3167
Balr
BIPOSOn IOOTB
_
aiatmcu
8STBOO
S3
us
us
"
-
us
IOBBBB
or cis us
a) 52
b| 39
a| 28
bl 76
cl 7
d) 35
8
90
al 20
b) 10
c) 5
d) 10
laiBE
a) lot given
bl lot given
..
a) 85-*90 ug/g
bl 90-517 og/v
c) 168-372 ag/g
a) 72-M7 ag/g
a) lot given
b) lot given
cl lot given
d) lot given
e) lot given
..
69-219 g/g
...
a) lot given
b) lot given
c) lot given
d) lot given
(•EIT
HE 1 1
a) 96.* » or - «.9
•9/9
b) 116.5 » or - 7.5
•9/9
a) 203.1 ag/g
b) 21*.0 ag/g
c) 2*5.9 ag/g
d) 2*6.6 ag/g
*) 175 ppe
b) 198 ppn
c) 165 ppn
d( 18* ppe
e) 156 ppi
131 » or - »0 9/9
*) 190.5 » or - 16.9
•9/9
b) 1M.O » or - 1«.6
•g/g
c) 150.7 » or - 16.8
•9/«9
d) 138.8 » or - 12.6
•9/9
PfcGH)
GEimi IirOIRlTXOI
•1 Boyn, ba*e-lin* valae
t) elrls. base-line valne
PX0.05
Ccntrol* received non-In fortified
cereal ana rent received cereal nith
2.57 19 addtd per day. after 9 no,
teat girls baa 30.3 ug/g nor* hair In
than control. (p<0.05) .
Btalthy children 33-90 no old (ienn
age 57.9 no), fton niddle in cone
(•nilici, enrolled in private
preschool ana kindergarten ic Denver,
1975.
BCTlLSs TltCB BLBBE1TS; II 1C;
CCRP1IKXTB mtOaiXOIS; BLOCD
ftasil: Bail; saliva; DIXIE;
CIILDKI; SEI; DIETS; COLOB1DO
a) Bales, 65-9* yr old, nithent
vitanln snpplesent
t| renales, 65-95 yr old, ultboat
vltasln snppleient
c) Bnles, 66-78 yr old. Kith
•nltlvitanin mpplesent
d) resales. 67-93 yr old, vith
eiltivitasin npplenent.
181; BLOOD; BtlB; II EL t ID; RtTaLS;
TiaCE SLEBMtS; VI1I8IBS
n) 1-6 no lactation
b| 7-9 no lactation
c| 10-15 ao lactation
d) 16-21 so lactation
e) 22-31 no lactation
Ihite Konen, 1-31 ao postpartas.
ElOOD SBBOli BILK; Bail; BBTH.S;
lacraTioB: caicxofl; Raonsxoi;
BaiaaiBSB; iioij CCPPBI: sue
Belght or height/age accounted for
6 souths. lulare County, Ci.
tHC; HaXB; CBXLDIBI; CiLXFoma;
lacm stODiBS; iniiiTxoiat
DtfXCXBICXBS; BBialS; 1UCS CLBBEBTS;
txoiiDicatois
a) controls, ages 28-60 yr
fc) Benoaialyxea patients, ages 38-6*
yr
c) Peritoneal dialyxed patients, ages
<«-65 yr
a) londialyxad patients, a get 36-58
yr
all patients differ fron controls,
P<0.001.
Patients with chronic renal failure.
IIIC: 1ETHLS; BIIBIU. BBT1B01ISB;
BtOOD PLaSia; EBTTBSOCITIS;
IEQROCT.TES; B1IB; DISBISBS; IDDLIS;
CC8P1B1TXVB EValOtTXOIS: ailllClia
RBFBBEICE
Ranbiage, K.a,
chavet, R.I.
Brovn, B.B.
lalravens, P.a.
1979
vlr, s.C.
Love, a.R.G.
1979
Vaaghan, L.I.
leber, C.I.
Kesberling. s. B.
1979
Brad field, B.B.
Banbldge, K.B.
1980
Bahajan, s.B.
Prasad, a.s.
tabbani, p.
Briggi, l.i.
BcDonald, r.D.
1979
(Jl
Cn
O
-------
Sloe
74W-66-6
Si
iti 65.38. ii «i9.s c. ar tot c. n i u 19 it «BT c. 10 •• ig «t 590 c
TIUOB
31C8
Udlir
3169
Kldlir
3170
LI »«r
3171
U»«r
•••usun Mm
• BURXCM.
BBTBOD
X-raj ipictroi
B
X-cay ipictcoi
ES
inaii
or casts
12
•1 133
b) 7«
c) 88
_
10
•1 91
bl «*
c( 7S
11 Ml
•1 lot giTin
b) lot gl*m
....
•I lot glriti
b) lot glim
e) lot glT«n
lot givii
a) lot giTin
b) lot glfin
c) lot ginn
,
(HIT
nn
•> 121 PPI ACT it
b) 196 pp* drr *t
•1 120 ppi
b) 103 tfm
c) 113 pp«
152 ppi dry ¥t
•) 159 ppi
bl 202 ppi
c) 201 ppi
riot)
QIII1U IITOIHMIOI
•I Rldllll
b) Cortll
2 Miplci p«r CUM. 2 U*ITMI p«c
(••pll.
S»pl«i tea* 197* iitopiiii ef 10
flu Indian*, • Mpigo, •>« I Cmk
n«Ua.
potissioBj eiKXDi; noi; COIPBI;
UK: IDBIDIOIi llOCUt LBkDl BR11S:
iiici niisns; ucvnt snmi WITII
IIDIBTS; 1DIPOSB tUSOl; VIICIBUl
BHSOIIBBIf BMHOOSj KROPSIIS
•1 lo rintl 41««ui
b| lc«t« r«D«l fillic»
e| Ciconlc nn«l fdlicu
•I «d b) dlftemt. K0.01
!•!••• •!• 6tj «t bill*.
iQtopiin at OCH Boipltal.
TIKI BIBIBITS; IBIUSi lOWFSIBSj
ClIIFOIIIl; IXOIBTS; LITBI; JPlOTl
exsBtsBS: irpnTBisxoi; SODIOB:
(OTISSXOI; CUCIBl; PBOSPBOBOS;
IIQIBSIOB; C1IMXOI; 1TK; COIPBI:
HID; IIOI; ItiatlBSB; U.OBXHII;
siLicoi; Txtinai: COBUT: IICISL:
eoiiiDBioi: Til; ciniiaB; snoitioa:
BIIIORt IITBUJH; SILTB1; TII1DXOB:
eoioi
2 uipU* f»t cuo. 2 «*ljm pic
•••pll.
197* tatopitia of 10 Pi» Xalliu. •
Fipago» and a Cmk Indiaa.
tOTtSSXOB; C1LCIOB: XBOI; COPPBI;
IIIC! IDBXDIOBl ITCKBlt LBaO; BBT1I.S;
TlaCB HBBBITSi LtflB; SPtBBI: WITl:
IIDISTS; 1DIPOSB TISSUE; Pll 01 BIS;
llaSOIBBIIT IBTIODS: IOTOPSHS
•) lo ciial disiaii
b) acnti rinal fallarn
c) chronic cinal failncu
a| difficult fcoi b) and c) , P<0.01
Valm aci dcy *t tasii.
• itopsln at DCLt loipltal.
tl>C8 ILEHBRS; BBflLS; aOTOCSXIS:
CILirOIIII; HDIIIS; LITEB; SPLBBI:
CISB1SBS; alPBBTEISIOi; SODIOR;
COTtSSIOB; CllCIOB; PIOSPBOIOS;
S»OIBSIO»; CIDBIOB; XXIC; COFPBI;
HID; IIOI; HIOtltSB; UOBIIDB;
SILICOI; TITtllDR; COB11T; IICKBL;
BOLTBDEIOR; Til; CBIOBIDH; STSOnlOB;
BIBIOB; LITBIOB; SILTII; T1IIDIOB;
?CBO«
IBFBIBICB
Bangilion, 1. P.
BUI, B.l.
ItlUon. t.K.
Bitoagk, D.J.
Chciitium, J.J.
Ixttt, I.B.
licbacdi, D.O.
1979
Indcapcaiit, s.
ilixaodic, O.T.
Ooalek. B.C.
197«
B»g*l«on, I. P.
Bill, B.l.
liiliop, K.K.
Bitoagb, D.J.
Chciitium, J.J.
Xxatt. l.R.
licbacdi, D.O.
1979
Xndcapcaiit, S.
llixandir, S.T.
Goaick, R.c.
197»
01
-------
tine
7MO-66-6
En
Itl 65.36,
RP (19.5 C, BP 908 c. TP 1 •• Bg at «B7 C. 10 •• Rg at 590 c
(COITIIDID)
TISSUE
3172
Long
3173
tang
sn«
lung
31TS
Bilk
BIPOSOBE BOOTS
iiunicu.
BETBOD
US
us
.-, — „,;
-'•'•
US
us
BOBBBB
or CUBS
26
at 63
_b| 15
68
a) 26
b) 39
O 23
4) 13
•) 28
f) 30
R»B8B
. ..
dot given
a| 70-96 09/9 dry vt
b) lot glf«n
75-96 ig/g txj »t
a) lot given
bt lot glT«n
c) lot given
d) tot given
•1 lot given
() lot given
_
IIIR
BEAI
130.0 ag/100 9 dry «t
a) 82 ug/g dry «t
b) 80 ag/g dry «t
88 «g/g dcr »t
a) t.CO » or - 0.23
«g/al
b) 1.05 * or - 0.15
•9/11
c) 0.75 « or - 0.11
ug/al
d| 0.63 » or - 0.09
•g/ii
•) 0.69 » or - 0.18
ag/nl
() 0.60 » or - 0.19
«a/U
P10I)
GEItBtL IBFOBR1TIOI
Sections of ling* Ira* aabj*ct> >ho
had be«n blto«lno«« coal lin«r» for
12-SO yr In Raleigh county. Bast
Virginia.
BITILS; TBICI ELMEITS; COIL;
BIRTUIVI; CCBlLT; CBHOSIOB; COPPER;
I BOB; LEID; BaGIESIOR; RtlGllESE;
IICKEL; TITIBIOB; UllDIOR; tIBC;
IOKS: CORP1HTITE ETH.01TIOBS;
SHICk; QDUTZ; ITBPH BODES; BEST
flBCHII
a) Coal aincu
b) Controls
s«ctlon« of lung* fro* decaaaad coal
•Iners and non-coal alners ftoa
Salalgh Co«nty, IT.
RHkLS; TBICE EtEBBBTS; COIL; SItlCl;
BIBTLLIVB; CBBOBIOB; COPPEB; I BOB;
HID; a»OBESIOB; BUGIBESE; BICKBl;
TITIBIOB; TlHDIOIj II BC; IOKS:
COBP1BITITB ETktOHIOISi IIS1
11BOIBH
Banga of Hans, additional data
available.
Sactlons of lings (cos d«c«assd lest
Virginia bitiminois coal slnics.
BETU.S; IBICE ILBHMTS; COtl; SILICi:
BBRTUIOB; cnOHIOR; COPPER; HOB;
HID; RlBIESItlR; RIBG1BS3B: BICML;
TIUIIOB; V4UDIOB; SXKi 10BGS;
ccRpiRiiivB mtoanois: IBSI
VIRSIII1
a) 1-3 10 lactatioa
b) «-6 ao lactation
c) 7-9 so lactation
d) 10-12 so lactation
e) 13-18 so lactatioa
f| 19-31 so lactation
•hits sosen. 19-«2 jr age, 22
pclaiparae and 16 aaltiparae.
HOOD SBROR; RXLK; BUI; BBTI1S;
L1CTHIOI; C1LCIOB; UGBESIOB;
B1IGIISSE; IBOI; COPPER: XHC
BEFEBEICE
Keenan, 8.G.
crable, J.v.
Saallnood, ».».
Carlberg, J.B.
1171
Sveet, D.v.
Ccoise, I.E.
Ccable. J.V.
Carl berg. J.B.
Lainhart, U.S.
197*
Carlberg. J.B.
Crable, J.T.
Ustlsca, L.P.
lorria, I.E.
Bolts, J.L.
Bauer, P.
lolonlcz, F.R.
1971
vanghan, L.I.
leber, C.I.
Keaberling. S.R.
1979
Ui
to
-------
Ilae
1MO-66-*
It* 65.38, HI «1».S C, BP 901 C. TP 1 mm Bg at Ml C, 10 •• Rg at 590 C
(COITIIOBD)
nssai
3 ITS
RUk
31"
Pancr«a«
3178
Placenta
3179
S*liM
—
BXPOSOBB IOOTI
1I1LRIC1L
RBT10D
US
X-ray •peetroB
11
US
IOBBBI
or cists
•1 76
b) TT
e| 23
41 79
•) 25
*
611
•1 36
b) 136
UIOB
•) lot gi»a«
b) Bot gltm
c) fat glraa
d) lot gl»*»
•) lot gl»a*
lot given
lot gl»e*
a) 0.0*1-0.0*9 ppe
b) 0.*26-O.S«S pp.
Bang* of eeane
(HIT
mi
•1 5.32 ag/Bl
b) 2.00 og/al
e) 1.16 «g/Bl
4) 2.0 «g/«l
•) 2.5 •«/•!
93.8 ppi dcr *t
70.5 » or - 13.5 ag/g
•) 0.0*6 ppi
b| 0.*7( pp>
PICE)
eBIBBlL IIFOB81TIOI
i) colostra*, high «od Ion IDCOM
gcoap*
b) lft«r l*ct*tlon 1-3 loathi, Ugk
•id Ion IneoM gcoapi
c| lft«r l«et*tlon > or • 13 month*,
high *nd Ion incoK groap*
«| Ittcc laetition 1-3 nootki. Ion
IKOM gcoip
•) tttn l*ct*tlon 1-3 coatk*. Ugk
iieai* gro«t
SlgnlCicint dif(«r«nc« b*t«*«B ineoi*
gtovpi «t 1-3 BOBtki bat Dot at *-6
iontk«. IddltioMl flat* «**ll*bl«.
loMn fcoi icban and cacti India.
HITIUl TB1CB ItBBIBTSl COPPIB;
B18IBSIOB; met BItK! COBMflTITI
lUtOtTIOMt DIBil tIKIS: BDI11.
•BUS! IIDIl
2 w«pl*> par casa. 2 analyaas per
aaapl*.
Saapl* froa 197* aotopiia< of 10 Piia
Indiana, a Capago, and * Creak
Indian.
POTISSIOR; CktCIOB; IBOli COFPEB;
IlICi ROBIDIOBS IXCKEL: LB1D; BCTHS;
TUCS ItlBBItS: LIVBB; SPLBBI; lOBTli
KIDIBtS; 1DIWJSE TISSUE; P1ICBE1S;
RIaSOIBBBIT BRBODS] IBTOPSIIS
Dry tit baala
Sa*plo>> fco* * koapitala ID
laakflll*. Tl.
PI1CB1TI; BBTItS; TB1CB ELEBEITS;
TlIieSSEE; BLOOD; B1IB; COIPUMITB
IfaLVlTXOIS; BBICOBT: LE1D; C1DUIOB:
snEiiOB; BOBiDiOB; IBOI; xiic;
COBllT
a) Stianlatad parotid aaliia
b) Baiting aind aallva
Idditlonal data availabl*.
Eaalthr adalta not Cuting, agad 19
to 51 TC. (coi Snaden.
BITllS; IIIC; COPPEB; BLOOD; BLOOD
PL1SBI; SILIfa; DBIBIBK; SET; 1DOLTS
nnuicB
Bajalakakoi. K.
Sclkaatia, S.O.
1980
Bangalaon. i.r.
Rill, B.I.
liaison. U.K.
Eatoigk, D.J.
Chrlstanaan, J.J.
Ixatt, B.H.
Bicharda, D.O.
1979
Baglan, B.J.
Brnl, l.B.
Scholart, i.
lil«on, D.
Larsan, K.
Dyac. 1.
Banaoar, N.
Schaffnar, I.
Hoffaan, L.
DaTlaa, J.
197*
Rathor. 1.
fallen iM, K.
Ibdolla, a.
1977
VJ1
U)
-------
Sine
7MO-66-6
lo
«t» 65.39, DP »19.5 C, BP 906 C, IP 1 M 89 at »87 C. 10 •• Ig at 590 C
(COITIIOBD)
TISSOB
3100
Saliva
31*1
Saliva
3182
Spleen
'
BIPOSDBE BOOTE
Ingestion
Ingestion
lULTTICIt,
IBTBOD
US
BS
X-ray epectroa
IOHBBB
or cisss
67
al 12
b) i
a
BalOB
a) lot given
b) lot given
c) lot given
d) lot given
a) lot given
b) lot given
lot given
(IBR
BB1I
a) 173 » or - 9»
ng/el
b) 30.5 • or - 1«.8
ng/el
c| 226 » or - 77
ng/il
d) 29 » or - 10.1
ng/el
a) 68.2 » or - 9.5
ng/al
b) «1.3 » or - «.9
ng/al
66.0 pps dry "t
MOB)
GEIIBlL IIPOBIUTIOW
a) (hole eiied saliva, subjects in
••rvsy - dietary Intake of 9.8 » or -
3.6 eg/day deterained by dietary
recall
b) supernatant of saliva of group al
cl Ihole sited saliva, subjects in
setabolic atady-11.6 » or - «. 3
eg/day included in diet
d) supernatant of saliva of group c)
lean In and protein concentrations in
aaliva correlated, tn levela In
saliva not correlated to seres or
hair levels
a) and b| 59 cases, c) and d) B
cases.
13. 5-1». 6 yr old girls participating
in either a 30 day aetabolic study or
a nutrition aervey.
HR1LS; TBaCB BLBBBRS; HIIBULSJ
HIC; SU.IV1; BLOOD SBiOB; HUB;
CCBPlllTITB EVllOtTIOIS; tOOIESCBlTS:
CUTS; RBTaBOLISR; IIDT1VA
a) Boys, base-line valne
b) Girls, base-line value
Boys' parotid saliva level higher
than girls* (KO.OS)
50» of children {control) received
non-ln fortified cereal and !0»
(test) received fortified cereal
ehlch provided 2.57 extra eg In per
day. ifter 9 so no significant
difference in saliva In of control
and test groups.
Be lit by children 33-90 so old (wan
age 57.9 so) , froa slddle incoae
(aailles, enrolled in private
preschool and kindergarten In Denver.
1975.
BETU.S; TBaCB BLBIBR5: ZltC;
ccnpiBiTivE mLOafiois; BLOCD
11*51*: Bill; SaLXTl: OBIIB;
CBILDIIIl SBI; DIETS! COLOMBO
2 sasples per case. 2 analyses per
eaaple.
197* aatopsles of 10 Mia Indians, a
Papago, and a Creak Indian.
fOMSSIOB; C1LCIOB; IHOIj COPPEB;
HIC; 10BIDIDI: IICXBL; LEID; IRaLS;
tlaCB ILBBBBTS: LXfBB; 3FLEEI; aOBTl;
IIDIETS; ADIPOSE TISSOBJ PIlCBBaS;
BBtSOBBBBIT BETBODS; tOTOPSIES
BBFERBIICE
Greger, J.L.
Sickles, T.s.
1979
Basbidge. R.B.
Chavei, I.I.
Brosn. B. B.
falravens, P.I.
1979
Bangeleon, I. P.
Bill, B.I.
llelsoa, K.I.
Eatoagh, O.J.
Christensen, J.J.
Ixatt. l.H.
ticharda, D.o.
1979
-------
Ilac
7a«0-«6-6
tn
Itl 65.38, gt «19.S C. BP 908 C. »F 1 M Bg It 1ST C. 10 •• Bg at 590 C
CconiniD)
TISSUE
3183
SplMD
3181
TMta
3185
Taatb
318C
OElM
sir*
Ocin*
tinsni MOTI
Dacaal
Inhalation
Ingaatioa
inLTTICtt
•ETIOD
ts
us
us
ID8BII
or C»SBS
•1 92
b) «0
CJ 76
•1 28
b) 28
-
35
1
•) 16
b) 16
HIDE
-
•1 lot gitan
M lot gl»an
c) lot glv«
•1 lot givrn
b) lot glnn
1210-34SO ppa
«06-1*520 ng/3» he
• I 22.9-55.7 ig/hc
b) 36.2-53.7 og/hr
(HIT
nil
•I 21.8 ppa
b) 29.3 ppi-
e| 30.* ppi
a) 132 ppa
b) 1(3 ppi
1620 ppi
«T16.75 n«/2« he
*) lot appllcabl*
b) lot applicable
PlOB)
GIKIal IIFOtBaTIOl
a) lo nnal dlMaa*
b| icit* canal fallacvi
c| Ckcoale caaal fall«c*«
a) U(f«r«nt tcoa b) and e)< K0.01
lalnta aca dry *t baala.
Intopalca at ocit Boapltal.
TltCI ElSHIItS; nialS; »OTOPSI8SI
cuiroiini noinsi UCTM: aims
OISB1SES: BTFnTIISIOl; SODIOBl
tOTtSSXOIi CklCIOli PBOSPBOBOSj
BigilSIOB; CtDBIDH; UK; COIMI;
tllOj IIOI; RilOtllSC; U.OBIIDB;
SI1XCOI; TXTanOR; COBklT; IJCUL:
(oifBDiioi; til; cnoaiua; snonioa;
BIBIOBj LITIZOI; SIlfBI; TtlUXOI;
fCIOI
a) II Bclatol
b| SI Brlatol
(•CM nan t pcaaolac t»«th col lac tad
feoa •ckool dantal cUnica in
lilatol. Dnltad Unqdoa.
etitts: IBID; SXK; CIOBIOB; COPPBI;
TIBXIt CBIlCBEIj OIITBD (IIOCOB
caibrliga. «» achoclchlldcan
TI1CB BIBBEItS; BIlllS; STBOItlOB;
mo; SODXOB; iteiisxoij sxict
FIOOBIOB; BISSiCBOSIRS; CII1D1BI;
IIHB; BElStUIBEIT BBTBOOS
lft« Ca-BDM adalaiatratlon
•9-TT-old chaalcal plant nockac (1966
to 1975) axpoMd to CdS. aalcnida
doit, aoaa aolabla Cd coapoanda.
Tcaatad for Fb poiaonlng. 19CS.
laaaltada, iwoaala, lighthaada^naaa,
haadach*. aaacla acbaa, joint pain.
[acaatkaala in Ilngaca. iapotvnoa,
algnlflcant «algbt loaa.
Blld ltf«c aolacgaaant with poaalbla
clccaotlc pattern and ealclflad
gcanaloaa on left lang.
BtTILS; CIDBIOB; LliO; SELEini;
tllC; BLOOD; OIIII; RIOIETS; BET4L
toisoiiiio: occopaTioiit atzins:
IC01TS
a) Control. 0 and 21 he aCtac 50 ag
Si
b) Clcchotie, 0 and 2a hr aftac 50 ag
In
Both gcoapa faattd bafoca In.
Ccnteola. patlanta «tth alcoholic
ciccaoala.
ZI1IC; CIIBBOSIS; OBIBE: BICOD;
IIBBISKI; IIST TIBCHH; SDICIBT;
CIICIOH; BtCIESIDB; COPPEI; IR»CB
llEHEITSi 01005; .lITltS; UTIB;
CISEkSIS
UTBIEICB
Indeapcuit. s.
llaxandac, 0.».
aoolek, B.C.
197*
stack. B.T.
Backltt. l.J.
llcklaaa. C.
1975
Bcadavold. F.
lada. t.
laaandan, I.
Bakkaa, T.
1975
Lccnae. s.
Bong, C.D.
Boxian, t.c.
1979
SnlllTan. J.P.
Jatton. n.».
Baech. B. E.
1979
tjl
-------
Sine
7OO-66-S
tn
It! 85.38.
BP »19.S C. BP 905 C, IV 1 » B? at «87 C. 10 •• 89 at 590 C
(COETIBOBO)
TISSDI
3188
Orlae
3189
QrlM
3190
Drill*
3191
grin*
EXPOSOBE ROUTE
Ingest Ion
Ingest Ion
IIILTTICIL
IETBOD
It
US
us
us
IORB8I
OF CkSBS
a) 1
b| 1
al •••
b) 31
a
12
-
nine
•1 3*2-750 ug/2* hr
b) 85-177 ug/2* hr
a) lot given
b) lot given
O.H-0.56 ag/day
•) lot given
b) let given
Bill
it «62 ug/2» hr
b) 131 ag/2* he
a) 208.3 * or - U.8
•g/2« he
b) 157.3 « or - 1H.2
ag/2» hr
lot gl*«a
•) 0.* » or - 0.1
•g/«»r
b) 0.* » oc - 0.1
•g/tar
(MR MOB)
GEIEBtL
a) Boalthf "ale, 6 saiplaa owe 9 10
b) H«althy f«ul«. 2 aaiples 10 ao
apart
Idditional dat« afall«bl«.
ICTUS; TBaCB B1BBBITS; (1SBIIC;
BIOBIIB; CILCIDS; CBLOJIIE; COBU.T;
CBBOIIOH; CBSIDB; COPPBB; BEJCOHT;
IODIIE; VOTIS5IOI; »IO»ISSB; SODIOB;
iOBIDIOSj SBLEIIOH; ZIK; OIIIB;
BBTROD:
•I Bor«, baaa-lin* *•!«
b) Girl*, ba««-lln« Talo»
Boys' 1«»«1 klgkcc than glrli*
(K0.01)
50% of chlliran (control) r*o*ino
non-Xn foctltiad cacval and SOU
(test) r«c«lt*d foctiflad oraal
thick provided 2.57 «tra «9 In per
lav. att«r 9 ao no significant
difference in urine Zn of control and
teat groups.
Bealthr children 33-90 eo old (aean
age 57.9 so), free aiddle inooee
faailies, enrolled in private
preschool and kindergarten in Denver,
1975.
TlkCZ BLIIEITS; II 1C;
CCBPkllTITE ZTalOlHOISi BIOOD
CIlSHIi Rkllt SlLZVi; OBIIB;
CBXLDIBI; SSI; DXB1S; COlOBitO
lean valves all groups daring *
eiperlnental periods of a dan each.
Subjects received 10.99 (10.52-11.16)
eg In/day eith basal diet or nith
kasal diet pins 1«.2 g/day sipplesent
cellaloie, heaicellolose or pectin.
Saall changes in sens content or
arioary eicretlon die to estra fiber,
significant changes in fecal aineral
loss.
Baalthy adolescent boys
•BTalS; tltCB BLEIEBTS; HIIBI1LS;
coppBi; sue; aiaiBsioi; BIOCD SBIOB;
OIIIB; fBCES; IDOIBSCBITS; FXBBBS;
CCBP1B11IVI zraLOkTIOIS; IBIUSU
a) lo« fiber diet
t) Bigh fiber diet
Ben 37 to 58 yr old.
Been daily balance »3.5 eg on
los-flber diet and -0.9 eg on
high-fiber diet.
I CHITS; OKIE; BBTI1S; TB1CB
ElEBBftS; OIKS; PIBEI3
Cornells, B.
Speecke, a.
Boats, J.
1975
Raabldge, K.I.
Cbaves, B.I.
Broun, I.B.
lalravens, P.».
1979
in
Dress, L.B.
Ues, c.
rox. B.a.
1979
(alsay, J.I.
Jacob, I. a.
Prather, B.s.
1979
-------
Sine
7*10-66-6
XI
7«*0-66-6
It* 65.38. Ht »19.5 C. BP 908 C. TP 1 » Rg at WT C, 10 •• 89 at 590 C
(COITIIOBD)
TISSUE •
3192
DCiBI
3193
orlM
319*
OciBi
ixrosou IODTB
Ing»tlon
Injactloa
kBllRICU
BETBOD
US
. »
US
-
us
EORBBB
or ciSEs
9
22
9
met
a) Bot gl»«n
b) Bot given
e) Bot gl**n
a) Bot gl»«n
b) Bot glTM
at Bot gU«n
b) Bot gl««
c) Bot glTM
d) Bot gl*M
•I Bot ginn
U1B
a) 0.66 » or - 0.0*
b) 0.60 » oc - 0.07
.g/day
c) 0.42 * or - 0.03
«g/day
a) 53.5 » oc - 35.5
>g/100 il
b) 106.0 » oc - 58.7
09/100 ll
a) 1792 » oc - 530
•g/2* kr
b) 1901 » oc - 393
•g/2» kc
c) 1607 » oc - 765
ig/2* kc
d| *13 » oc - 11*
ng/2* kc
•I 709 « 41mm, 11-63 r> ola- 4l1
ID good physical eoadltlon.
•RtLS; TBkCI BtBaBRS; BIIBHLS;
C»OBIOH: co*pn; •MOIBBSB; me;
CC8P*BITITB BTlLOkTIOBSi FBCCS:
OBIBB; IDDITSl DIETS: IBTABOlISHl
ZU.IBOIS
•I stocag* batticy «ock*ci bit on
tc«at*«t ultk xinc and Tltaaln c
b) stocag* batt«cy wockicm attic 2*
•k tcaatncnt nith sine and vltanln c
lcck«», ag*d 28-60 yc. In battery
plant *-3* yc. 100 eontcoli >ltk no
knoin Pb upoaac*.
LUD; SIBC; COPPBB; BE«tS;
BLBIBBTS; BIOOD; BLOOD SBBOI; 1KB;
BBBOSLOBIBS; OBIBC; DISIS; TR1BII C
a) I*«k 1
k) Silk 2
c) tMk 3. 6 mbj«cts
d) Ink «. 3 aobjacti
•t l««k 5. 2 nbj*et«
Billy •xcc«tloa foe ncc*»l»i mki
dnclrng total pac«ntical natcltloo
•Itk a solition coBtalolag 200-800
ig/1 In. Iicntlon l*cr«uad In
Bo«top«atl«« gconp aoiitood nk 1-3.
Canc*c patliBti, agoi 12-63 yc, nan
•llfkt Ion at 18.9 » oc - 3.2)1 fcoa
pc«-lUaui Mlgkt.
XIBC; COPPII; BETIIS; BXBBBal
BIUBOUSBt BIOOD SBBOI: Oil IE I
BBOPllSBS) DIETS
HZFEHEECB
SpenclC, R.
l>naM«n, c.B.
Boltsnan, a.B.
Kcanc, t.
1979
Papalounon, R.
Sohlic, i.
Pfilfdc, c.c.
1978
Ln
Loncy, s.p.
eoodgan*, J.t.
Salth, J.c.
Bahic. B.«.
Bakick, B.B.
••nkln, B.I.
Bnnnan, B.p.
1979
-------
llac, (dlkyorogoB 3.7.12.17-t.tEaB«t»yl-8.n-4i»liirl-2.18-porpkio«aipcot>lo!i«t«{2-M- (• CI|
Site. {T.'2-41*tk«Tl-l.B>13.17-totraMtkTl-21R.23B-p<>rplilB*-2.18-dipcopaBoato(2-»-l(2 1) ,1(22) .l(23),a(2*)|-, (SP-1-2)- (9 CI)
15M2-««-5
C3«-«S9-B»-OB-lB. 21
II 62C.03
nssol
3195
Blood
3196
Blood
ixrosni loan
1I1LTHCII.
BBTIOO
FlBOEOMtCT
IOIBII
or CUBS
•I 1295
b) 305
28
._ _.
1UGB
() 62-87 aMl«»/Ml«
b) S0->1000 uol««/lol«
18-2W 09/41
nil
» lot glm
b) lot glT«B
S».2 «g/dl
antitL iiroiRiTioi
c« popalttloi
b) Oectptttoaal «»po««r« to toad
r«r iol* koiogloblo.
Dinisk i«n oenpttlouUr •zp>nd to
fb.
tUD; OCCOPITZOIIL
BlltlDS; •IISOIIBBIT SnBODS; BUMDl
BIROOLOBIIS; BITIBOUTBS: DIBUBt;
ICOITS
Ircn >ock*Ei oxpoicd to load oxldo.
Boto data a*ailabl«.
Icon rackoca npalElag an olnatod
rk IB lac lock City.
callcoad B«t«ork
IHDI IIIC; BBTalS; TIICE BLUNTS;
flCTBTISi BtCOO; OCCOPITIOI11
BIXIIDS; III TOBR
IBFBIBICZ
ScaidjoaB,
1979
riaekbolB. 1.
lillB, I.
1977
Ul
U\
00
-------
1-(«'-Miloropk«oyl|-«-(CTClob«ijrl-V-pl[»r«xi.tiTl-«'-cirt>oi7l.«t«-bat«n-1-o!i« hylrocklarlAe (»o poetise* la CBMIIII! .
TISSBB
3197
Blood.
placBa
3198
VrlBe
ItnSOIB IOOTI
XBgeetlOB
XageetioB
mtnxcit
•BTHOD
BadioBetry
•adioBetry
IDIBBB
OP CiSBS
1
1
IlIGE
a| lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
e) lot applicable
f) lot applicable
a) lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
BUI
a) 0.29 eg eg.al*/el
b) 0.1* ag ogalv/el
c) 1. *3 «g eq«l»/al
d) 0. 2* eg ogfliv/Bl
e) 0.31 ag efeiT/ll
C) 0.0* eg eqeiT/il
a| SS.B «
b) 16.5 S
c) 5.7 1
d) 2.3 *
OEICItL IITOBItTIOl
•I Total radioactivity at 0. :s kc
t) Free b»»« ooocentration at 0.25 he
c| Total radioactivity at 1.C kc
d| Free baee eoBcenttatioB at 1.0 hr
e) Total radioactivity at 6.0 ht
f) Free bait concentntloo at 6.0 hr.
If tec a 50-19 (0.7 eg/kg. a«.s eel)
dem.
lealthy eale mbject (aged 51 it. *t
7S kg).
nines: iiriBoutis; mint BIOOD
nun
a) 0-12 hr
b| 12-2* hr
c) 2*-«a hr
d| «8-120 hr. after SO-eg (0.7 eg/kg,
*9.S «Ci) doM.
lealtky eale nbject (age 51 yr. «t
75 kgl.
D100S; SBTiBOlITBS; 01IIB; BIOOD
itlSII
IBFBinCB
Baikine. D.I.
aoore. D.H.
Chaswaed, L.P.
1977
Bivklae. D.B.
Boon. D.I.
Chaneaed. t.P.
1977
Ul
-------
1-MtaaOM, 1-(10-(3-(»-a«thTl-1-plp»r«i»Tl)proprllph«notki««lo-2-Tl|- (8 CIJ
1-Bataaonc, 1-(10-(3-(»-a«thjl-1-plp»r«iayl)propyl)-10B-ph«notlii«iin-2-Tl)- (9 CI)
6!3-03-2
C2»-B31-I3-0-S
HI «09.«0, BP 270-280 C at 0.05 •• 19
TISSB8
3199
Mood.
cell*
3200
Blood.
pi ana
BIPO30BB BOOTS
lag* it ion
InoMtion
uumcti
HBTBOO
ruocoiottr
-
PlHOCOB«tCT
IDBBEI
or CUBS
12
8
ItlGB
n-78 n«Al
0-592 ng/«l
nil
lot glvan
114.8 D9/C1
GBIZIlt IirOIIATXOI
Dc«« of BO if/lay
Chronic •chliophrcnlo. ««ch Kith
dcio-(c«« naihoat of 2 kk.
DROSS; DIOO 1BIIIPT: BLOOD PUSB1;
IinilOCITIS: BOIROIRS; IBtTCOS
SISTBB DISUSES; SH; IDOHS
D«lll do««l, (0-160 19
Chronic •ckiiophraalcs, *>ch «itk a
A»9-frM «uko*t period of 2 «k.
DIOGS; 0100 tailtPIi BLOOD PU3B1;
EIITBBOCTTES; HOIBOIBS; IBIfCOS
STSTBB DISUSES: SEI; IDDLT5
lEfBUICE
Slitk, I.e.
T»llD9«. C.I.
Citjton, J.I.
D«kiri*nji«ti, B.
Davis, J. 8.
1979
Siltk. B.C.
Taiilnga. c.i.
ctayton,.J.«.
D*kica»nji«n, B.
Oavii, J.H.
1979
-------
1-upktkol (8 CI)
1-lapktkaloDol
»0-15-J
C10-M-O
If 1M.1C. IF 96 C (prUu). IP 26* C
TI5SOB
3201
OclB*
EXPOXHIE IOOTB
minxcii
BETBOD
.. - -
inmi
or ctsis
b) 10
0 «
•IMC
a) «.2-ia.e ppa
b) lot d»t«ctad-8.91 ppa
c) 0.07-2. IS ft*
SE»I
a) tot glfoa
b) lot glT»B
o| lot glnn
.
GIIIML xiroiunoi
<) Poatleld* focaalatocs at a
cacbacrl plant vitkoat piotvctlr*
clothing
b) Co* tleiflo foraulatori at a
cacbacrl plait who toe* pcotoctin
clotklng
c) FatMca
tlSTICXDISt OHllonoSPItKS:
PBBIOtS; BET1BOLIHS; MIIZ; IOBTB
ClIOLIIli COBPlHTIt! BULOtllOIS
-
UniMCB
Skatlk. B.I.
Brad«*y, D.I.
-------
1-a*nten-a-7a-3-ol. l-caloto-3-athyl-
113-18-8
C7-B9-O.-0
«l 1M.61. BP 173-17* C, alao repoctad •• 181 C
TXSSDI
3202
Blood
3203
Blood
320*
Blood.
plaana
3205
line
-
EIPOSUSE 100TB
IngaatlOn
iiunxcit
HRIOD
ec
EOBBBB
or cists
1
«3
1
1
S1B6B
Bot applicable
0.5-83.0 ng/nl
•) 91.5-59.2 ag/1
b| 67.8-12 19/1
Bot applicable
BE1I
• ag/100 al
32.7 ag/el
«) Bot applicable
b) Bot applicable
So ag/100 g
CEIII1L IBPOBBtTIOE
••dlcal eiaainar caaea of deatha fcoa
Intentional or accidental 00, at
uadetecelned oc natiral ca«i«a.
DBOGS; aOTOPSIBS) BBPBBIDI1B3;
SOICIDSl B100D; OBIBB; LITIBj BUB;
CIOO 1BOSI
D«atk caascl by drag cacblnatlons
B«cord> of 1239 d«ath« in 0. S. and
Canada. In all, dlanpai oc its
aatabollt* ••» pr«««nt in tb»
tiuM* aid, la »o»t CM**, «or« than
oa« dcig •*• found. lgo«i !«• than
5-9r««t«t tain 65 yc. llgb fr«g«»ncy
cf mlcldo. oth«r data avallabl*.
pglnonacy and *i
-------
*-(«-eU0roFk«Byl)>a-kyar«y-B.l-41»«tkyl-al.pfci.i'lpka-aiplMBn-
CI*~H3-C1-I2-O2
•• trr.o*. n Byaracuaru*. 222.223 c
TX33CI
3206
•loo«.
ixfontt lomi
tiumcu
nnoo
tu
IOBBBI
or CISBS
at «
bl «
»MB
-
a) lot gives
b) lot glvm
•ill
a| 2.19 » or - 0.36
b) 2.2* » or - 0.«
giBiUL iiroBBinoB
•) »«ak. 2.* » or - 0.7 kc attar 8 9
do** IB lyciB
k| *••!(. 5.2 » or - 0.3 kt after 6 9
dom IB capaalca
Biological availability aaa« (or
•yrqp or capnlaa.
6 kMltby Ml* volaMco aga 36- »3
Diaest DIOO tmiiPTs coiPiitnn
IfttOlTIOBS) BLOOD SBBOBt III JBStTl
iDotTs; iBraoansntii suiisis
nriBncB
Ulliagw. J.B.
talntraBb, B.s.
Fall«r, B.l.
1979
Ul
^
CO
-------
1,V-Blpk*nrl. J,2',3,3'.».»',5-fc»pt«ckloro-
350C5-30-C
C12-M-C17
•I 395
TISSDI
3207
Blood
EIPOSniB ROUTE
HILTTICU.
mi oo
oc
IOBBEI
or casts
•I 9
b) 7
11IGE
*) lot gl»a
b) lot 9lvm
nil
•1 0.28 ppb
b) 0.11 ppb
GEItllL IirOHIIlTIOI
•1 Tasko pitlvnti
b) Controls
fitivnta irltk Ta«ko and norctl
pccion* fro* tk« koapltal ot KjMka
OllviraltT
JIHI; BLOOD; BIOiCCOBOUTIOl;
CBIOIIIB OBGinC COIPOOIDS; IDIPOSE
1ISSOB; BIPBIITL COBPODIDSi ROD
C01T4HIIITIOI
IBrEIEICE
Karoki, B.
Buada, T.
1977
-------
C12-B3-C1T
•I 3*5
IT5SIB
3208
Bitosni toon
iiuniciL
BIWOS
8C
_ _ _ ._
B01BBB
or cuts
....
•I «
b) 7
UIOI
•1 lot glfm
b) lot gi?«B
•HI
•1 0.0 ppb
b) 0.12 ppb
aiBBUi iiroBiinoB
•I I»ho p«tl«nt(
b) COBtZOll
IttUnta iltk Tuka ufl Bond
P«EMB» fzoB th* ko«plUl of Rfnhi
Jipii; BtooD; BnuocamanoBi
CBIOIIBB oiatnc caBMomsi IO»OSB
TISSOB; BIPBntl COBPOQIDS: (ODD
CCITtBIMTIOl
BBFBBBBCB
KBtokl, B.
Band*. T.
1977
-------
3S06$-2«-2
C1Z-B«-C16
Bl 361
TTSSBS
3209
Blooi
.. .
BIPOSDH IOOTB
BRBOD
OC
... .
IDBBII
or cisis
•1 9
b| 7
11WOB
a) lot gl»«n
b) lot gl»«o
UMI
a) 0.65 ppb
b) 0.17 ppb
REICML IirOBNlTIOl
•) Tnaho patlanta
b) Controla
tatiants «Uh toaho and noraal
paraani troa the koipltal ot Kjushu
OolTacslty.
JlPkl: Bloat; BioncconatiTioi;
CItOBIlE OBCHIC COHPOOfDSi IDIPOSE
ItSSOE; BIPgHIl COSPOOTOS; FOOD
CCITtBIItTIOl
EEFESEPCE
Knrokl. H.
Baiada, I.
1977
ON
-------
t.1'-Blpk*»Tl. 2.2«,«.«',5.S«-k«Mckloro-
3SO«5-27-1
C12-BV-C16
n act
TUSVI
3210
Bloo«
BXMSOIB BOOM
tnimciL
BKBOD
QC
IUBBIB
or cists
•1 9
b) 7
uni •"
•) lot gin*
b) Bot glvm
nit
•) O.S2 ppb
b) 0. 15 ppb
OBBIUL inOlRlTIOl
I) YMhO pttintl
b) Contcoli
p«ti«nt« «ltb Tuba u< nonil
pcnoni fco« th« beaptttl of Kyaska
D«lT«»ltT.
jicii; BtooDj BiotccannLtTioi;
cnoixii aiainc COSPOOIDSS IDIPOSB
IXSSBXt BXFBIBYL COBfOOBDS; RIOD
CCBT1BZBITXOB
BBTIMBCB
KaroU, B.
Bu«d«, t.
19T?
Cn
-------
CU-M-C1*
III U<
TtJ» hospital nf n ya*Hu
Jir»»i nitirri Pio^crn^niiiTToin
cnoiiTiii aintvir ccKPoimnjj IMPOKC
imuii MPHKTI ccRH>n»pj| tono
limn-in f
K«rokl. H.
n«««dt, T.
00
-------
1.1.e-*etkeie-ll-er>lok«t*(o4J tett*lei-l-o*e, i,Ik,],!«.«,S, 1.U,Sfc.«-4moklorooot*kfaro-
•• It •* II C
ew-eiio-o
n tw.4i. t»
I mm
1
uu
*^
1111
•lie
HI*
•lood
1111
lloo*.
pltllt
•mnn wtti
lULTtlCIl
ratio*
B
oc-tc
•C-IC
III ill
or cut*
i
___
i
,
i
i
tITCI
.,
lot iBpliatble
e) 1(S* ItS «f/lk kr
b) 14D-14S «•/!» kr
o) let *Mllo»kU
f) let ••elleeble
dot eiBllaable
let five*
iiii
»,0»1 If/I
t) 1*0 •!/!« be
k) Ml. > ««/» kt
a) 1*1 if/11 kc
41 ••» •«/!« kc
e) 111 »»/» kc
t) HI •«/!« kc
«.0 «,/•!
JttO M/el
mini tirokHUtai
1 eoitke itter !••« known *i|«e«re.
M-»t-ol4 eit eipoted to oklcc4eoene
lee t lottk*. T-t«be lepltet 1*
eeieek bile 4eot.
tiiticiDiii tint iinkcaiTiti
vimiiki Mem noo»i loircsi
itiioti siBimiti tunai
imcconiiTioii i»tsi comutni
lUUITXOUl NMIIT
•1 Cklec4*ae»e 1* klle 41*ec«e4 Icoi
4to4em
(1 Ckloc4eeeie alaokol U bile
4l*erte4 tree 4ie4e»i
g| Cklec4eae«e, »ltk reletveieii of
«Dt et bile Into 4to4e»»
41 Ckloc4eo«ke elaekol, »ltk
r«Ut»loi ol 101 tile lute 4*e4et«e
el Cklec4eeo»e, «ltk c«Uf««lo» pl«i
14 i/Atr ekele«tictkU« r««u
It Cklec4eeeie tlaekel, «l«k
celnteele* alee 1* «/4*y
ekelMkrctilM ceelk
ill eteilee pr*tn«t*4 iltk
(leo«cokl4tM> t«l«M tec l«c«e
***lltble<
l»-ir-ol4 e«n ei»ete4 te okl«r4*ao*e
tec t Mtkki. T-t«be lepltvt U
cotton bile teat.
HiTiciDin inn imnunii
fllailTIl IKHl llOOIi IOIVCII
iioicomiinMi m*i comutm
1UIS»TMI»| HMtIT
^ lontha «ft«r lant knovn ••(otur*.
RtntBvn d«t«ctabl« !•?•!, ^ (tq/el.
kt-ir-e!4 ekk, eipe«e4 te aklac4eean*
let t lontke. T-t«be lipltnt lit
cone* bile 4eot.
Mtticioiii mil imKimii
vnaiiiii riciii noooi iDircii
uiiaii iiDtiniii »un*i
lIOkCCQHIl&tlOl | l&TIt COirkMTIVI
l»UOkT10»«l 1DMIIT
CkUr4.c«,. ..,oe.4 p,«l.»... pooUd
•••pl*«.
ntTiciDiii HOOD »umi niiiamitiiT
IITKOOS
iiriu»ci
leylu, J.J.
Cok», ».J.
Igle, J.L., Jc.
kitkU, 1.?.
•etelltn, ».J.
(Of 1*1, J.J.
Cekk. ».J.
lal*, J.I.. Jt.
•Ink*. ».».
••tell**, f.J.
»oyl«o, J.J.
Cokn, V.J.
t«l*. J.I., Jt.
*Unk«, «.».
aai*ll»n, r.s.
""
PUMl«, k,V.
Fftrlfl*, H«V«
arltfltK, F.D.
Gui*\l*n, P.
1»"
\O
-------
l,»:5.9-Dl.«th«non«phth«l«n«. 1,2,3,a,10, 10-heiacnloco-1.».«a.5.8,8a-heiahjdro-, endo,eio- (8 ci)
1.e:5,8-Dleetl>anonaphthalene, 1,2,3,«, 10, 10-heiacbloco-1,a.aa,5,8,8a-lxeiahydco-. (1alpha,«alptia.«ab«ta,5alpha.8alph 20-75 ft old,
>••?!•• takin dutlnq «cut«
b) Dan**, 1-15 yc old, iodd«c d*ath
tj saicld* 01 in «»to accidents
B«dltn *•!«•*, b>««d on lipld »t
««t «t Ttloo tvallabl*.
Qravnland nonindoatcializad ac«a
0«»ack IndHtcialiMd.
IOIPOSE TISSOB; 101; tOTOPSIIS;
CILOSIIB OIBIfIC COBPOOIDS;
FISTICIDIS; ODD; Dtt; DDE: OIBLORII;
SlPHCaiO* IIOIIDI; MlTCHloniHBD
IIPBBITLS; CQRPUtTItt BTiLOITIOIS;
POPDLITTOI IIPOSOIE; OBBBIllID;
OIMlIK
Bilk »>pl». ho«pltal» In ortan
Oilo. • «ai(l«« (co« Balllngdal, a
taller In >oitn«rn lor«ay. Bo
cccipatlonal •tpo^ic*.
I UK; IISECTICIDBS: LICttTIOl;
CBLOlIliltD BTDIOCilBOIS; CBIOIIIB
OIQMIC COBPOOIDS; PESTICIOBJ; EOBlaY
a) TV do«» at 1 acl
b| Topical adiinlitration of 1-5 «Ci
P«cc«nta9« at don (icotid In 120
ni. Data In b) eorcactvd toe
incomplete tecorec) baaed on data in
a).
Baaltkj «oluteec«.
BBIBICIDBS;
OBOtlOPBOSPIHBS) CBIOIIIB CCG1IIC
CCBPOOIDS; OKIE;
BIUCBMIOCICLOBUIBI
BEfEIEICE
Jenaen, S.E.
Clausen, J.
1979
Bakken, H.r.
seip, n.
197«
Feldaann, B.J.
Balbacb, H.I.
-------
,«iS.8-DiMtkaioiapktkal«M, 1.2.3. (.10, 10-k«
O F«ni« - 7o» re
D(t* available for lBt«ri«diat* 19*
gcoipi.
lltopir IpcclMDI. 1967-1971. frol
InciclU iltk DO koora occipitlaoil
•ipoian.
(isnciois; nsKTiciDis; ciioini
CKtHC COBPODIDS; DDT; DDIi ODD:
DXEIDIII; BKTICB10I IPOIIDB; IDIPOSB
1ISSOI; ISIldt RIUCHIOIOCTCLOBIXMI
Cmaiiiw team BiitccB CiMfli (16) ,
Oaitae (50). Oiticlo (57). catral
Cuidi (22) ud flatten Cinita (27) .
1972.
PISTICIDBS; CBLOIXII OIQ4IIC
COBFOOIDS; DDti DIHOIXI;
IOLTCBLOIIIITID BIFBBITLSJ DB; ODD:
lOUCBLOll BUkCllOIOCTCLOIIUlI;
OITCHUJBOill! IIPT1CRLOI BFOnDI;
IDXPOSI IISSOBj CklkDl
I) 11 1970
b) FT 197*
Conc*ntc«tlaBi OB llpld b>iii.
Poitioct«i« ud blop*l«i tkc«9ko«t
O.S.
BHK; PIStlCXOZS; 1DIPOSE TIS50B;
iiuiautis: CBIOIIII OBOIIXC
COHPOOIDS; CBMIXItTID HTDBOCIBBOIS;
1ICT1TIOI; OIICHlOtDtIB; DDI;
lOltCBLOI; BIPTiCBlOI IMXIDI;
CXILDIIli BIUCBiOiOCTCLOBIXWIi DDI;
OKTID StlTIS
•) 0-* rr old
ti s-2« re old
c) 25-«4 re old
d) »s» re old
(•111 IBd (
-------
l.ltS.a-Dlaatkanoaapkthalana. 1.2,3.*. 10. 10-kaxachloro-6.7-«poxr-1.*.aa.5,6,7>s.8a-octahrdro-. ando.aio- (8 CII
2,7:3.6-DiaathanoDaphtk(2,3-t)oxicaM. 3,a,5,6,9,9-hax«chloro-1a,2,2«(3,6,6«,'','J«-oct»tiTdro-, (1« alpha, 2bata.2aalpht,3batat6bata.6aalpha,7tMta,7aalpba) -
60-57- 1
C12-B8-C16-0
Rl 3(0.93, IP 116-177 C. YP 1. 78110 (B-7| aa Rg It 20 C
(COITIIOSD)
CII
TISSUE
3223
adlpoaa
322«
IdlpOM
3225
IdipOM
3226
adtpoa*
BXPOS01I IOOTB
Inhalation
lagaatlon
allLYTICIL
RETEOD
OC-BC
GC
- ..
GC
-
-
RUBBEB
or cists
•) 26
b) 39
C) 122
d) 99
•) 151
(| 70
70
a) 33
t» 17
1
UIOE
a) lot gllan
b) tot gl»«n
e) lot glian
d) lot gl»ao
•) lot gl»«n
(t lot gi»an
0-0. S3 ig/kf «itr«ct«bl»
fat
_
a) lot giTva
b) lot giT«D
lot applicable
-
HE*I
a) 0.33 ppi
bl 0.«3 ppi
e) 0. 35 ppa
d) 0. 3t ppa
a) 0.38 ppa
O 0.27 ppa
0.16 ag/k9
•itcactablt (at
a) 0.13 ppa
b) 0. 12 ppi
0. 10 ppa
GIIIBIt IlrOIHtTIOl
a) 1969
tl 1972
c) 1969-72 (fwala*)
d) 1969-72 (aal«a)
•1 1969-72 (Haxican-kaacican)
t| 1969-72 (non R«tlcaa-aa«cican)
(atlaati oadccgolnq •l«ctii« aacqacr
IB 1969-72 la tk« lo»«c Bio Grand*
1all«r of >o«th«aat T«iaa.
(ISTICIDIS; DDT; REPUCBLOB FPOIIOB;
CBLOiiii OIGIIIC ccarooios: IDIKSS
TISSOE: TH»S: REXlCHLOBOCTClOHtUIE;
DCE; ODD; DIEIDBII; JOITCBLOHHITEO
IlPREinS
Itdoaiaal tlaaa*
Saapl«a (COB adalt aalvs g«n«rallT
had klqkaat coBcantcationa. Sax
diKccaacaa algnificant at °'.\ !•»«!
la savacal caM>.
«catia« aaccopalaa of adult ubjccta
>24 ye old aad 2 atlllbocna ID
Casaack.
PISTICIDBS: DDT; DIEIDBII;
COITCBLOIIIlTID tlPBEITLS; CELOBIIB
CtGllIC C01CODIDS; iDIPOSE TISSUE;
Hall; Lit IB: COBP1UTI»I
IVlLOtTIOIIS; aDOtTS; IBnOlll
D(I»IK: SBI
a| Icaealandara, 20-75 jt old,
iiapl** takan daring tcata
lapacotoaiaa, la»«l« lnccaaa«d iltk
•9*
t| Danaa, 1-75 yr old, aaddao daatk
tj aalclda oc IB auto accldanta
ladlan valaaa, basad OB llpld «t
l«t »t talaaa avallabl*.
Ccaaalaad noalnduatciallud acaa
Danaart Indgatclalliad.
tDIPOSE TISSOE; (01; 10TOPSIIS;
CBLORIIB OIQIIIC CCRPOOIDS;
PISTICIDIS; ODD; DET; DDB; OmOBIl;
BIPT1CBLOI HOI IDE; MLTCBLOfllKEO
BIPBEITLS; COBPtltTIVE B»1LOITIO«S;
POPOLITIOI EXPOSORE; GBBBIL1ID;
OHHaRK
Coac«BtcatloB unchangad «-5( days
attar Ingaatlon c( 170.1 9 7'%
dlcklo(antklOB.
Salelda attaapt by 6J-yi-old aal*.
SOICSDE; FtOIXDa; IOTOPSIES: BLOOD
SEIOR; lOIPOSE TISSOE; LlfBI; GILL
CLaDOII; KIDIETSl PISTICIDIS;
OiailOfHOSPBJTBS; BLOOD: DM; DDE;
OIILDIII: REPTaCBLOl BPOXIDB;
BIIICBIOIOBEIIEIE; LtflGE; IWBOLOGIC
BIIIPBSTaTIOIS; tlOtCCOHOLlTIOl:
R.IT1MLITIS
_.
BErEBtRCE
Ducna, J.E.
197«
Kcaal, I.
Kaclog, 0.
1976
Jana«o, G.E.
Claaaan, J.
1979
Davlaa, J.E.
Bacgoat, i.
TcMd, T.B.
Bagaa, a.
Borgada, c.
Sonnaborn, a.B.
Taclarak, C.
197S
(HIT USE)
Ln
-------
1.«lS,S-DiB*tkaBOn*pktkal«M, 1.2,3.a.10,10-k«ackloco-6,7-«poxT-1,».aa.5.6,7.8.8a-octakyarc-, «n4o,*io- (6 CI)
2,7i3,6-DlMtkaaoB*pkth(2,3-b|oxir*M. 3,»,5,«,9,9-k*xacUoco-U.J.2a,3,6,6».7,7«-octakydco-, (1aalpka.2bata.2aalpba,3bata,6lMta.6aalpba.7|Mta.7Mlpka)- (9 CI)
60-57-1
C12-B8-C16-0
!• 380.93. IP 176-177 C. It 7.78X10(1-7) U If at 20 C
(COITIIOED)
nssoi
3227
Blood
3228
nooi.
a*C*B
3229
Bcala
3230
Ll»ar
BlfOSBlB BOOTI
iBURTciL
•moo
oc
CC-IC
- .
oc
oc
man
OP CMBS
•1 109
b) »97
•I »7
b) 13
c» 1
21
18
UISI
•t 1-25 ppb
b) lot gl*m
a) 5-1*0 ppb
b) 5-1* ppb
c) lot applicable
0-0.20 ag/kg axtcactabla
f»t
0-1.07 ag/kg axtcactabl*
fat
(•BIT
Oil
a) 5 ppb
b> 1.5 ppb
a) »3.S ppb
b) 10.1 ppb
c) 5.0 ppb
0.057 ag/kg
•xtcactabla fat
0.29 ag/kg
axtractabla fat
PiCB)
QIIIUL XHPOBUTXOI
a) Saaplca In nkicb 4i*ldrla •««
poaltlMly ilutiflcd
b) til caiplu
Po«tiort«u, Tlcglnla stat* ndlcal
(ualavn Offtc* 1972. Iboat «5X
fEoa «fclt« »!•«, 30* froa black
aal«. 151 froa nkita (••«!• i. 10«
ftoa black f«ul««.
CBLOIIIZ OBGinC CORPOOIDS; IDT: DDE;
OinOIII; TIIQIIH; BIOOD;
P1STICIDBS; POLICBIOK11TBD
BXPIBinSl aiHCBLOBOCTClOHtUHB;
BIPTICBL01 IPOXIDI; CILOBIIlTID
BTOROCklBOIS
>) Balca, hoaacholda with on* oc aoca
i2« yc old aad 2 atlllbocna In
Daaaack.
PISTICIDBS; DET; DIBIDKI;
PCLTCBLOIIItTID BIPBJIIIS; CaOUIB
OIGkllC COBPODIDS; IDIPOSB tISSOS;
Hklll LIfBB; CORPlltTITE
BlUOkTIOIS; tDOLTS; IBIBOBI;
CCIHkIKi SCI
fcoa adalt aalca gaaacallr
kad klgkaat coacantcatloBB. Sax
dlftacancaa algaltlcaat at 9«f !«•!
la Baiacal caa«a.
Bcatia* B«ccopal«a of adalt tabj«ct»
>!« yc old BBd 2 atlllbocBB in
Danaack.
PISTICIDBS; DDT; DIEID8H;
ECltCRLOIIIkTID (IPBBITLS; CttOBIl!
OlOtllC CORICOIDS; iDIPOSB TISSOB;
eitii; UTEB: coBPiaiTirt
miomois; tooLts; ISIBOBB;
DIlBklK; SEI
BETBBEBCE
Orlffltk, P.O., Jr.
Blank*, l.T.
1975
Stare. B.C.. Jr.
lldclek, r.o.
RcDoagall. K.D.
Bonne*. L.I.
197*
Ui
Kcaal, I.
Kaclog, 0.
1976
Kcaal. I.
Karlog, 0.
1976
-------
1.*:S.«-0iMthanonaphthal«na, 1.2,3.1.10,10-h«iacbloro-C,7-«pox7-1,a,aa.5.6.7,e,Da-octahraro-. •nao,»to- (8 CI|
2.7t3,6-OUathanoaaphth(2.3-b)oxiraM, 3,a,5.6.9.9-aixachlaro-1a.2,2*.3,6,6a,7.7a-octahTdro-, (1aalpha,2b*ta,2a>lpha. -beta.«b»ta.6aalpha.7lMta,7aalpha)- (9 CII
60-57-1
C12-RB-C16-0
Bl 380.93. BP 116-177 C, It 1.7«10{E-7) » Bg at 20 C
(COtTTIOED)
TISSOB
3231
Bilk
3232
Hilk
3233
Hilk
323«
Bilk
3235
Hilk
eiPOSBB! BOOT5
UUTTICaL
RETROD
GC
TIC
GC
oc/as
BOBBSB
OF C1SIS
57
6 Of 50
— ;• ...
2 of 51
a) 20
b) 12
O ao
d) 31
.) 19
f) 20
9) 19
al 10
b) 25
el 35
d) 10
•I 20
C| lot
glTin
BIIGE
Trac*-0.05 ppa
0.3-3.6 ppb
lot gi*in
a) lot givin
bl lot givan
c) lot giTii
d) lot gl»an
•) lot giTin
f) lot giTin
gl lot giTin
a) lot giTin
b) lot gitm
c| lot glT«n
d) lot giTin
•) lot giTm
C) 1-6 ng/g
(BEIT
HEll
<0.01 ppi
2.75 ppb
0.01* ppi
a) 0.1 pp*. fat baaii
b( 0.15 ppi. Cat
baali
c) 0.17 ppi, fat
baiii
d| 0.18 ppi. Cat
baili
•1 0.20 ppi. fat
baiii
f) 0.1 ppi. Cat baaii
gl 0.1* ppi. Cat
baiii
a) 2 ng/g
b) 1 ng/g
e» 2/ ng/g
d| 1 ng/g
•> 2 ng/g
C| 2 ng/g
MOB)
GEBIBIL IIPOBBaTIOB
lactatlng «oian in selected areu of
Irkanaai and Hissisilppi.
BTLK; PESTICIDES; kDIPOSE TIJSOt;
BITMOUTRS; CB10BXIE OBG1IIC
COBPOOBDS; CBMBIIATED HIDBOC1BBOIS;
UCTITIOI; OITCHtOROHB; DDT;
IOIICRLOI; REPTACBIOR EPOXIDI;
CItlOU: RmCRIOlOCTCLOREIUB; DDE;
imiStS; BISSISSIPPI
Hilk saiplis. hospitals in urban
Clio. * inplia Cros Balllngdal, a
Taller in lootharn lor«ay. «o
cccnpational ixpoaara.
BU.K; tiSECTICIOIS; UCTIT10I;
CILOBIIITED BXDBOCiBBOIS; CHtOttBB
C BOW 1C COBPCOIDS; PESTICIDES; BOB»»I
Bandoi nbjicti of graatir St. Louis,
BC, aitropollton ana.
tISTICIOBS; CRLOIIH OIGallC
CQRPOOIDS: DCI: DDZ; OIBLDBII;
RKICRIOIOCTCLORIXME; REPT1CRLOB
EIOXIDE; Hill: RISSOOII; COBPtRJTITB
CfaLOaTIOIS
a) 1971
t) 1972
C| 1973
d| 197*
•| 1975
f) 1976
9) 1977
Eatiiatad froa graph
Bethari in Osaka Prafoetnr*
EIPRIIIL COIPOOIDS; CBWBIIB OlOallC
CCRMOIDS; Otl; DDT; DXBtDBIl;
BmCBtOBOCTCLOHIIIBE; J»P1B ; BILK;
FOltCBLOBIIltn) BIIRnnS
.
a| East ac n Canada
b| Qubae
c) Ontario
d) Central Canada
•1 Bastirn Canada
fl Rational aTiragi, iiiplii aboTi 1
ng/g
lattoail SartiT, 1975
EIPBEItL COMOOIDSt CIIIDt; CBLOBIIE
OI8IIIC CCHtONDS; DOB; DDT;
onLoBii; mrracBLci EPOIIDE;
atiUBioBOBtizEii:
BIHCHLOBOCtCLOBniBB; Hill I
•OliCRlOl: OnCRLOIOMRt PESItCIDBSl
rOITCHLOBIIITZD BIPHBBILS]
toircnoixiHiD TEBPBBBTIS
BZFZBEICE
untt. r.v.
Strasaian, S.C.
Toba, ».R.
1976
Bakkan. t.F.
Slip, R.
1976
jonuon, T.
tin, o.J.X.
tribrutir, J.
(•ttalbnt, L.t.
Drnckir, B.
1977
Takoihlji, T.
•atanabi, I.
Raiiabara, K.
Toihida, S.
Rori, S.
Fnkusblla, S.
RaiHlioto, T.
Roriia, It.
(anita. I.
1979
Rll, J.
Davits, D.J.
1979
-------
1.«>S.B-DlMtbinoMBktkalsiM. 1,2.3,a,tO,10-k«acliloeo-6.7-a'DO»y-1,«.»a.5,6.7.»,8a-octaky«ro-, mato.no- (8 CI)
2.7t3.6-DlMtbananapktk(2,3-fc)oxlrana, 3.«..5,6,9.9-ki*ackloco-1a.2,2«,3,6,ea.7,7»-octak»4co-. (1aalpha.2bata,2aalpka,3bata,6bata.6aalpfca,7Data,7aalphi)- (9 CI)
60-57-1
C12-BS-C16-0
It 3(0.93. IP 176-177 c. n 7.70I10|8-7| u Rg at 20 C
(conznio)
TX53DI
3236
•Ilk
3237
•Ilk. fit
3236
am. fat
3239
am.
•hoi*
i
BXfOSIIIB BOOTB
.
tniRicii
HITIOD
oc
OC-BC
.
OC-EC
-
OC-EC
IORBBB
OP cists
•1 27
bl 10
el 10
d) «0
•1 S3
b) 33
•> 3*
b| 6
22
11 MI
•I 0-0.010 ppi
b) lot gl»an
c) lot glTaa
d) 0.001-0. 015 ppi
-
a) lot datactabla-*. 66
ft*
b) tot datactabla-0.081
PP«
•1 0.0«-0.62 pp.
bl 0.03-0.17 ppa
0.003-0.011 ppi
•Ml
-
•1 0.002 ppi
b| O.OOS ppi
c) 0.070 ppi
d) 0.005 ppi
•I 0.1BO ppi
b) 0.025 ppi
...._.
a) 0.15 ppi
b) 0.120 ppi
0.004 ppi
aiEBUL IlrOBBlTIOI
•I Cotton, con, ml •aaaaa-gronlng
acaa
b) tai«M mi
c) Cotton «t««
d| coftoi-gcovlng icw. El silviAor
•|-c) U eiitmli. llgkist **• of
pwtleltei on cotton.
•otkm Ccoi lo«-incoii fiilll«« In
6»t«iala and Bl Salvador, ana*
chuon to cvpnaant dlffarant daqroii
of u« of paattcldai.
O**CIM of paitlcldci a particular
pcoblai In tcopieal coontci**.
Pcanlonc* of nalaatcltlon ley
ccntclbat* to koiltk «f facts.
ICIICOITOIB; CfllORIII ORSUIC
COBPOOIDS; CtOP OOSTXIB; DDI;
CKLDBII; Bl SltHDOB; POOD
COIttgillTZOI; eoiTBUla;
BIItCBlDIOCICLOBIIHE; BBPTtCBLOB
EPOIIDBi IISBCtlCIDBSl BILB;
lOtSITIOHl OBriCIBtCIBSi PBJTICIDBS:
EISTICtDE MSIDDBS
a| 1966-1970 itidy
b| 1977-1976 atady
196C-70 patlanta (Onlvicslty of
llbacta Boapltal). 2-10 daya
poitpartan. 1977-78 patlanta (public
baaltb of fleas of llbacta) . 17-309
daya poitpactu. Saaldancaa, Edaontoo
oc llbacta.
BILK: PESTICIDES!
BHtCBLOBOClClOBHIBE; ODD; CDB: DDT;
CIILDBII; BBCTICBLCB BMXIDBi
BBIkCBlOBOBBIBBIB; ClIlDt;
PCirCllOBIIKBD BIPBBBnS;
CCBPmtHB BnlOITIOIS
a) Blgk paatlclda giaga ac«a
b| lo« paatlclda a«g« acaa
loaan llflng la Stackvilla,
Blnlialppl (low paatlcida aaaga) and
Calta acaa (high paatlclda naagil.
Saiplai In 1973-1975.
BILK; PESTICIDES; CDB; ODD; COT;
BmCBIOSCCTCLOBmiS; BEPtiCBlOR
BCOIIDBi OKCBLOIDIIB; DIBLOni:
IISSISSIPPI: COBPIBITITE EVilDtTIOIS;
BIISOBBIBIT BETBODS
Sic»ay, laatacn laitcalla, 197Q-1971
22 nacalng aothaca, «t »6-66 kg.
living «lthln a 30 at radiaa of
Pictb, la a tarn tnstcalla
BILK; PESTICIDES; AOSTBiLIA; DDT;
DCE; DIBLDBI1; BKICBtOBOBEIIBIIE
BBFBBBICB
da Caapoa. B.
Olaiyna-Barsya, I.E.
1979
caccla. 8.».
Kadis, T.».
Bnltkcaltx, I.E.
Cannlngkai, G. a.
Bean*. G.I.
.1979
Bacnatt, B.I.
D'Brcole. l.J.
Cain, J.D.
Irthar, l.D.
1979
Stacay, C.I.
Tkoaai, B.R.
1975
-------
1,a:S,*-Dl**taanonaphthal*n*. 1,2,3.a,10, lO-h»iacbloro-6,''-«poij-1,«,««,5.6,7,8,lU-oct«hf{lco-, endo.cio- (8 CI)
2.T:3.t-Dti*tk.tnon*pktb(2,3-b)oxlc*n*. 3,«.5.6,9,9-K««»chloro-U,2.2«,3,6.6«,7,7«-ocUhT4co-, (1aalph*,2b*t«,2aalpha. 3tMta,«b*ta.6a«lpha,7b*ta.7ulpha) -
60-S7-1
C12-R8-C16-0
Bl 380.93, Ht 176-H7 C, »P 1. 78110 (E- 7) •• Rf »t 20 C
(COITIIOBO)
CI)
Tissue
32*0
OttB*
MPOS1II« ROOTS
Injection
D«CBll
KiimciL
RBTEOD
SadlwctCT
IORNE
OP C»SBS
6
III IDS
•) lot glt«n
b) tot giiM
- M.i"
•1 3.3X
b) 7.71
OEIElll IIFORHtTIOl
•1 IT a0»« o( 1 act
t| Toplol *diini«tc>tloD of 1-5 ad
P«cc«nt*9« of do** *icr«t«4 In 120
he. Data In b) cocr*ct*d tot
inco*pl*t* c*coT*r; band on data in
a).
Kaltby iolont««cs.
PISTICIDES; RBIBICIOES;
OlSaiOPROSPIalESi CRLOIIIE OFQkllC
CCRPODIDS; OIIIE;
BIHCRIOIOCICLORIIIIE
VirEREICE
F*ld*ann» 8.J.
Ralbach. H. I.
197«
01
-------
Ulph«fl,S*lpk>R-foctrop»*-2t»t>-(»cbo*ylie acid, 3b«t«-krdroxy-. Mtkrl ••t*c. bnxoat* (••t*c) (8 CI)
9-tnbiC7Clo(3.2.1)octu*-]-carboxTlic «cid, 3-(b*»oyloX7)-, Mthjl attic, (11-(«xo^zo)) - (9 CI)
18717-T2-1
C16-B«-B-0»
81 2«».3«. It 86-92 C
nssra
12*1
Drtm*
•nosim IORB
Inl«ctlo*
tiunxcii
HRIOD
ac/as
_
IDBBBI
OF CUBS
3
I1IQI
>) 1.15-8.0 ig
b) 3.20-*.22 «g
e) 0. 26- 1.63 «g
mi
*) ».11 ag
b) 3.68 ag
cl 0.93 «g
-
CIltllL IIFOI81TIOB
• ) 0-2 he
b| 2-« kc
c) »-S kc
ltt«r 100 «g eouiM IT.
ti«lt patl«nu.
DlOeS; kDDtlS; OBIBB; 8B1SDBI8BIT
8IT80DS
1BPBIEICB
Jlndal, S.P.
Late. T.
Vut«rga>rd. P.
1978
01
-------
1»lphaR,5alphaB.-Trop»na-2beta-carbox7llc acid, 3b*ta-hrdrorr-, b»Blo«t« (ester) (8 CI)
e-*ublCTclo(3.2.1)octane-2-carboxyllc tcld, 3-(bm»rloxrl-6-uthrl-< (II-(«to,»lo) (- (9
519-09-5
C16-R19-I-0*
II 289.)*. BP Tetrihfdrate 86-92 c (decoip 195 C, dry)
TTSSOI
32*2
Bile
32*3
Blood
32««
Brai*
32*5
Liver
32*6
Lm 9
32*7
Orloe
EIPOSOBB IOOTE
imnicat
RETROD
OC
GC
GC
OC
GC
OC
IOBBBB
or casts
2
3
1*
2
1
1
BUG!
0.36-3.0 a 9/41
0.14-0.76 19/41
lot applicable
0.25-0.9 ig/100 9
lot applicable
lot applicable
RSAI
1.68 19/41
0.*2 19/dl
0.3 19/100 9
0.58 19/100 9
0. «0 ig/100 9
10.0 19/41
CEIBRAL IBFORH1TIOI
Cecaine-r«lated 4eaths
Pcstiortei aaiples flroi overdose
(atalitles Involving cocaine.
DIOGS; BETkBOLITES: AUTOPSIES: BLOOD;
OKIE; 8ILE; BB1IR; LIVER: LOIGS
Cccalne-related deaths
Pcstsortes sasples (roi overdose
fatalities involving cocaine.
OI04S; lETaBOLTTBS; AOTOPSIE!; BLOOD;
OBIIE; BILE: Hall; LITW; LOIGS
cocaine-related death
Pcstsortes sasples (cos overdose
fatality Involving cocaine.
CIOGS; BETaBOLITES; AUTOPSIES; BLOOD;
OtllE; BILE; BBIII; LITER; LOIGS
Cccaine-related deaths
Postsortes sanples froi overdose
fatalities Involving cocaine.
DBOSS; RETABOLITES: AUTOPSIES; BLOOD;
Otllf; BILB: IIIII; LIVES; LOIGS
Cccalne-related death
Pcataoctea sasples fros overdose
fatality involving cocaine.
DBOOS; HETABOLITBS: AUTOPSIES; BLOOD;
OIIIE; BILE: BRAII; LITER: LOTOS
Cocaine-related death
Postsortei sasples fros overdose
fatality involving cocaine.
DRUGS: RITABOLITES: AUTOPSIES; BLOOD;
OIIIE: BILE: Biui: LITER; LOIGS
RBFEREICE
Valentoor, J.C.
Aggarval, T.
Hcoee, H. P.
Goxa, s.c.
1978
Valentour, J.C.
tggarval, 1.
BcT««, R.P.
Coxa, S.I.
1978
Talentoor, J.C.
Iggarval, V.
Hc4ee, R.P.
coxa, s.«.
1978
Valentour, J.C.
aggarwal, T.
RcGee, H. p.
Goxa, s.f.
1978
valentour. J.C.
aggarvsl, T.
BcGee, H.p.
Goxa, S.I.
1978
Talentonr, J.C.
aggar«al, T.
Rcoee, R.P.
Goxa. S.I.
1978
00
-------
1alpkaB.5alpkaB-Tropane-2beta-cacboiyllc add. Sbeta-kydcoiy-, Mtkyl eitec. bencoate (eatecl (8 CXI
9-lsablcyclo(3.2.1)octaae-2-cacboiyllc acid, 3-(bea*oyloiy)-8-Mtkyl-, lltkyl eitec, (1B-(exo.exoU- (9 CZ)
50-36-2
C17-B21-B-0*
it 303.31, It 98 C, Bt 187-1(8 c »t 0.1 •• Bg
nssoi
32*8
811*
32*9
Blood
3350
Blood
32S1
Blood.
plan*
3252
Blood.
plaaia
3253
Blood,
plima
•noson BOOTB
Ingest lOB
lakalatioa
Injection
Ingeitloa
Intcenaaal
intmciL
BRBOD
ec
OC
Iiidoensyiatic
oc/as
ec
oc
BOIBBI
or MSB*
2
3
•
6
10
«
It BOB
0.82-7.6 ig/dl
<0. 02-0. 17 ag/dl
122-125 ag/100 •!
11-1*9 Bg/ll
•) Bot glTiB
b) Bot giTiB
c) Bot giTiB
d) Bot glim
e) Bot given
t) Bot 9l*«B
g) Bot giTiB
k) Bot giTiB
1) Bot glTin
J) Bot giTiB
k| Bot giT»
1) Bot glTm
•) Bot glren
B) Bot giTiB
o) Bot glTen
•) Bot giTiB
b) lot giien
c) Bot given
d) Bot glvu
•) Bot glT«B
f) Bot gi*«B
BBtB
«.21 ig/dl
Bot gtvra
Bot gl*«B
76.67 Bg/ll
t) 221 ag/il
b) 109 ig/il
c) 21 Bg/ll
d| 308 ag/il
•) 170 sg/il
f) «9 ag/ll
g) 19 BgAl
k) S3 ag/ll
1) 16 Bg/ll
1) 80 ng/»l
k) 115 Bg/il
1) 27 Bg/ll
•) 128 ag/il
a) 206 Bg/il
o) 117 ag/il
•) 0.0 ag/il
b) 209.8 Bg/ll
c) 6.2 ng/il
d) 36.2 ag/il
•) 160.6 ag/il
f) 35.6 ag/il
GBBSU1 XBTOIB1TIOB
Coc*lB«-c«latid d«>thi
fOltlOttll Illplll fEOI OT«EdOB*
(•talltlii liTolTing coca in*.
DBDOS; BBTIBOLITBS: 101OFSXBS; BLOOD;
OBXBB; BI1»; BB1XB; LIfBB; tDBOS
CocilM-cclatid dcathi
Poataoctva «aapl*i tcoi oiccdow
(atalltlci liTolwlag cocaln*
DBOOS; BBTaBOlITBS; aOTOPSIBSl BMOD;
OBIBB: tilt; BBIIB; LXfBBi LOB8S
Toxicology ca»*. Bang*, 2 TOlwnt
•xtcactloB
-------
1alphaB,5alpaaR-tropane-2b«ta-carboirUc tola. 3beta-hrdroxr-, Mthyl ester, benzoate (ester) (8 CI|
8-atablcrclo(3. 2. 1)octane-2-carboxrUc acid. 3-(benxorloirl-a-Mthrl-, aethyl ester, (1B-(exo,exo| | - (i Ct|
50-36-2
C17-B21-i-0»
HI 303.35. IP 98 C. IP 187-188 C at 0.1 •• Hg
(COITII01D)
TISSUE
325«
BcaiB
3255
Ll*er
3256
long
325T
Urine
3258
OCiM
-
BXPOSOB.B B00t«
Injection
IBILYTICll
NETBOD
CC
GC
GC
GC
GC/HS
,.
(DRBS1
OP C1SBS
1
2
1
1
3
mot
Not ippllcable
0.03-0.11 xj/100 9
lot applicabl*
lot tppllctbl*
a) 210.9-578.2 a«
b) 25.«-1T».2 ag
c) U.a-38.2 ag
n»i
0.9 ig/100 g
0.07 ig/100 g
0.9 «g/100 g
1. 1 ig/41
a) 3*1.8 ag
b) 110.8 ag
o) 22. T ag
CFIIItL HrOB1»TIO«
Cacaioe-cclitcd death
Co«tioct«a aaipl«> (coa ovwtoi*
(•talltf iDTolTiog cocaine.
CI01S; HETIBOLITZS; HOTOPSIES: BLOOD;
CBIHB: 9ILB; BBIIR; IITEP; LDROS
Coctla<-c«lat*d d
Pcataoctci >aapl«« froa o»«rdo»e
tatalltla* lofolftng cocaine.
DtinS: BETtBOLITES: tOTOPSIBS; BLOOD;
DBIIE; BILE; BBtlli LIVEB; LOVGS
Cocain«-c«lat«d death
fatality infolring cocaine.
DBOGSi BETIBOLITES; nTOPSIE£; BLOOD;
0»Ht! BILE; BBIII; LITBB; LOHGS
Cocalne-celatad death
Pestaoctaa iaaple« froi overdose
(atalitr Intolviag cocaine.
CIOGS: HETIBOLITES; IOTOPSIE5; BLOOD;
OBIIES BILE; Bltll; UTEB; LODGS
a) 0-2 he
b) 2-4 he
c) 0-6 he
liter 100 *
-------
. 2,J-41hTa«D-3-(Z-liT4ro»T-3-U1-««thrl«thTll«»i«o)propo»y)-2-ph«Yl-.
-10096-11-9
C20-I2*-B2-03. C»-B»-0«
Bl «56.S«
»-. C»)-2-but«n«41o«t«
(nlt|
TXS30B
3259
BlOOd,
MEM
BIBOMBB 10BI1
XBJ«CtlOI
Xig«*tlOB
UklRICU
RITHOD
OC-IC
IOBB81
OP CUBS
•1 1
b) 1
d 1
11 1
UMB
•I 0.5-0.006 ag/il
b) 0.07-0.011 ag/ll
e) 0.2-0.021 ««/•!
A) 0.39-0.0(8 uy/ml
BUI
«) (at «i»«B
b) lot glT«n
c) «ot glm
4| lot gin>
SBKUl IIFOIBITIOI
•1 IT. 1 ig/kg. 30 fin. 9 he
t) Oral. SO 19. 2.0 hr. 12 hi
c) Oral, 100 19. 1.5 hc-12 he
d) Oral. 150 19. 1.5-12 he
Iitli«t»d tram graph.
OIOOS; BLOOD SBBORi HBlSOBBBnt
BITIODS; ritlCE; tITUBBRTTHIIC
IOEITS
BBRBBICB
••«•••, D.
Popvlalca, P.
B«n«r4. I.
PiagoUr, P.
Oc*golr«, J.
1980
oo
-------
l»-PTr»lolo(3,»-a>PTri«l
he aftac l«st dosa, ••aaucvd as th«
Ktabolltc.
PitL«nt8 «ith lyipbou or otfcec solid
toiocs.
C103S; BLOOD SEROH: lEOPLkSHS; TO THE;
IIITDES; BFT4BOIISH; imtBOLRES
JBftJtUCt
Hande, K.
P«»d, '.
Chabacc, 8.
19->8
Ul
oo
K)
-------
1l-1.5-a«B«odlazapiaa-2.«(3B.SI)-dlOM. 7-cmlOEO-1-aathyl-S-pa«Brl-
223t6-«7-8
C16-B13-C1-I2-02
It 300.71. |f crystals 180-1B2 C
tissni
3261
Blood
32C2
Blood,
Plaaaa
irroson MRI
lagaatloB
XagutloB
uumcai
BITBOD
Plaoroaatrr
PlBOCOMtrr
IOIBBI
OP CaSBS
IS
IS
mas
3.2*-B3C.« Bg/Bl
.
•) 131-953 ag/il
b) 398-1395 Bj/al
e| 27C-706 Bg/Bl
Bill
.
lot glf«B
» 593 sg/Bl
b) 663 ngSBl
c| 579 ag/Bl
GEItllL IIPOIIHIOB
Clofct*«B » l-d«*M«kTl Mtlbcllt*, 0
»A 2 kc «(t«c *0 19. 352.3 Bj/il at
6 he. final TBlM.
15 ••!••
fipll comtciction at peak blood
Ivrali.
DIDUS; DUO IHIBIPT; BtOOD; CBOBBIa;
BIHtTIOl tISOIDBIS: DIHBIaB!;
VSTCIOTIOPIC DIOOS; COBPaBHITI
HILOITIOIS
ii i • i
a) adiUUtvnd aa tablat. aaaa peak
tlM l.«a he
fet adalal«t«Ead a* capaal*. n«n peak
Urn 1.75 he
c) tdalnlat«c*d in aolltlon, aaan
peak ti» O.B7 ht
Caak l«T«la aft«c W my doava
DKfacmeaa not •IgalflcaBt
othar data atallabla.
B««UhT. dc«9-fc*« •Anita, IB- 23 It
old, 155-175 Ib
Popil dlaaatvc aaaaai*MBt« after
IngaatloD o( dcag coccvlatad "1th
flaaaa !•••!•.
DIOOS; DIDO TBEIaPt; B1IZOBUI JPIIBS;
II TXfO lltLISIS; COHPaUTITI
B»»LO»tIO»S; BLOOD PUSH; 51ORQU
1IPBIEICI
Kotxan. J.I.
Madhai, T.B.
BoalgtMcg, t.l.
TallHC. J.J.
St««act. J.t.
Beo>a, i.J.
Jan. H.t.
1979
Tallnar. J.J.
laadhaa, T.I.
Jon, I.I.
BEOIB, ».J.
Staiact, J.T.
Kotzan. J.t.
BoBlgbvrg, t.L.
1978
i
00
U)
-------
naipha-sstradioi - (9 CI)
C1«-H2«-02
II 272.17, a; 220-223 C (needle* »lth 0.5 B20 fros not alcohol)
TISSUE
3263
Urine
IXP050RB BOOT!
IIILTTICkl
HBTBOD
OC
1011881
OF CIS IS
«l 12
b) 3
cl 3
Bll ICE
a) lot given
b) lot given
c) lot given
flEll
a) 31.7 og/2« kc
b) «8.6^/2« hr
cl 3«.1*/2» he
ItKBtL IKPOBBATIOIt
a) poBta0noFftusal aabj«cta givan
conjugated estrogen tablets daily for
21 days
b) °03tianopaasal sab1«cts given
conjugated estrogen tablets (1.2S ig)
dailv toe 21 days
c) °ostienopausal s«tajects given
ccnjagated estrogen tablets 12.50 sg)
daily cor 21 days
•ean la average of leans for days 17,
1C, 19. endogenous level also
available.
12 healthy feeales, aged 37 to 57 yr.
lit Sa-73 kg.
HoaHOMS; STEBOTDS; OB IKE; Sit;
mSOBMBIT HETBOOS
_...
BErSBEKCE
Johnson, B.».
Hasserano, B. p.
Kho, B.T.
tdass. W-P.
I^'S
oo
.e-
-------
19-Ior-1Talpha-pregii-»-ei>-20-yB-3-one. 17-mydroiT- (8 Cll
19-Iorpr«ga-«-en-20-TH-3-o»e. 17-ay«ro«y-. (ITelpbel- (9 Ct)
68-22-4
C20-B26-02
•I 298.11. at IS 1-162 C
TISSVI
326*
Blood,
plena
1
I
BIF030BB BOOtB
Iage«tloa
Injection
II1LTTIC1L
KTflOD
HI
IDIBII
or CISB
6
ItMB
•1 18-0.28 B9/I1
b) «.5-0.2 ng/il
•Bll
-
•) tot git«n
b) Bot 9lT«n
«BHUl IIFORHITIOB
•1 ««no» at M»a 1 ud 2* hr «tt«r
•laovl do«« of 1 19 norathioteon*
•octet* and !0 19 •thlarl««tndlol.
I*
t) I«ng« of crana 1.5 and 2* he after
•Ingl* doM of 1 19 nonthindcoM
•c«tat« and SO 09 •thlaylcitcadiol.
oral
eloaxpon*ntlal decline. Betleated
Cioi graph.
tolaateere. 21-23 IE old, faated
tetore doelng.
oioGS: DIOB IBEBIPIJ OBITBD KHSDOB;
ICOtTS; BLOOD FliSM; HOCBSTOOBIS:
SI11OIDS
BBPBSEICE
Back, D.J.
Breckenrldge, l.B.
Cravtord. F.B.
Reiver, R.
One, B.t'K.
Bone, P.B
Selta, S.
1978
00
-------
2(1R)-PTrlel41nan*, tetrahydro-*-hrdro*T-1-beta-o-rlbofaranosrl-
C9-R16-R2-06
TISSOE
3265
Blood.
plaaaa
3266
Ociae
eirosDiE ROUTE
Inject to*
Inge at ion
Inleetion
Ingest ion
iiALTTicAL
RETROD
EH
RadionettT
ER
Radloaetej
R OR BEE
OP CaSRS
a) 2
bl 2
c| 1
a) 2
b) 2
c| 1
BARGE
a) 0.25-35 ag/al
b| 0.3-9 «g/el
c) 0.09-0.8 ag/al
a) 38-9* X of doee
b) *-Rf t of dose
c) 1-22 % of don
REAR
al Rot given
b| Rot given
c) Rot given
al Rot given
b) Rot given
c) Rot given
GEBtRAL IIFORHATIOI
•1 IT, 0 and 2* he
bl SC, 0 and 2* hr
c) Oral. 0 and 120 he
lov-peak after 200 ag/aq a. Peaks at
0 and 2 hr.
^ patient* ulth aallgnant aelanoaa.
CHOCS: DBOU TRERAFT; CHEHOTRUAPT;
TtXAS; ERXTRESi RECFLASRS; RILAROHAS;
BtOOD FLASHA; DISEASES;
RAOIOISOTOFES; SKIR DISEASES
.
a) IT, 0-2* be
r| SC, 0-2* be
c| oral, 0-120 hr
lot-peak after 200 ag/ag a. Feaka at
0-2 hr.
f patleata «lth aallgnaat eelanoaa.
CIOOS; 01 OC TRERAPT; CREROTRUAFT;
TIIAS; ERSIRES; RECFLASRS: RtLARORAS:
HOOD FLASHA: DISEASES;
BADIOISOTOPES; SKIR DISEASES
BEPERERCE
80, D.H.W.
Rodey, 6. P.
Rail, s.t.
Bonjaain, R.S.
Brovn, R.S.
Frelceich, E.J.
Loo, T.L.
1918
Ro, D.H.W.
Eodey. G. t.
Rail, S.R.
Benjaain, R.S.
Brovn. R.S.
rralrelch, E.J.
Loo, T.L.
1978
Ul
CXI
-------
1 (IB) -tyclBUlBOB*. B-««l«o- S-tt»OEO-
2022-85-7
CB-HB-r-83-o
II 129.0*. II 295-297 C toocoip)
nssvi
32C7
Blood.
••£••
326S
OclB*
BIPOOTBB toon
Ing* «t Ion
InjVCt lO*
XBg**tlon
Injection
1BILRXC1L
•moD
8M.C
BPtC
BOB BIB
or cists
•1 5
b) 5
cl 3
4) 3
•1 3
b| 3
Cl 3
11 3
•I «
11KI
B) lot givw
b) Bot gl*w
e) 20.0-31.7 sg/1
4) 22.2-31.2 Bg/l
•) lot glT«n
b) Pot glroB
c) lot gl»n
d| lot giMB
•) lot giTOB
Mtl
(1 11.2 ig/1
b) 8.7 .7/1
e) lot gl**>
4) let gt*M
l) 255.7 (g/l/»6 hr
b) 2M.8 «g/l/«e kc
e) 229.2 «g/ly*8 hr
4) 212.7 «9/l/«8 hr
•) «07. 1 igA/«8 he
GBIBItl IBFOIU1IOB
•) (••Ithy futlng «bj«ct«-i*>k
l*f«l-*0 •!• «ft«r 500 ig ocdly In
lolitlon
II BMltkf dating •abj*ct*-(«*k
l«nl-1 kr •(»« 500 ig onllr ID
cipnte
c) ratlmta «lth c«n>l
iMiieieiCBcr-pMk !•*•!*-* be «tt«r
500 or 1000 K orally IB c«pial«
4) P*tl«nt« «ith c«»l
li»f(lcl«ncr-p«*lc
l«r«l«-«ppcoxl«*t*ly 10 «in 41*lT«l*.
OBOOS; DB06 IBBBtPT; FlOOBIil
CCBfOOBOSl COBPIUtm BfllOniOBSl
IB TITO IB4HSI9; 8UOO SBBOI; OBIBBi
8ITABOLTSR! BiSBXBGTOB
•) SOO ig orillr IB tgMOM lolatlon,
fi«tlBg
b) 500 Bg ocillj la ctpMl*. fBitlBg
c) 500 Bg ocilly IB c*p*Bl«. «tt«c
4) 500 Bg octlly In capnl*. *ft»r
BBtteU
•) 500 Bg lBtc**«Boa«lr
4«t« «*BlUbl«.
sibjccti «ith noEBal c«o«l function
I8-»0 yc o!4.
DBOOSt DBOO 1BBBIPI; FIDOBIBI
COBMOBDS; COHPlBlTIfB STUOMIOBS;
II TITO IBUTSISl BLOOD SBBOBi DBIBB:
BirBBBBCB
Cotlvc, B.B.
BlBlc. I.D.
I«lly. B.B.
1978
Cntlu. B.E.
BlBlc, Jk.D.
K«lly, B.B.
1978
Ln
00
-------
2-Butanol, a-(dlnethylanlno)-3-arthyl-1,2-dlph«nyl-, proplonate (ester), (25,38)- (B CI)
Benxeneethaaol, alpha- |2- (dloathylaalnol-1-aethylethyl|-alpha-pbenyl-, pcopanoate (eater), (S-
««9-62-5
(B»,S»)|- (9 CI|
C22-II 29-1-02
Bl 331. «S, BP 75-76 C
TISSUE
3269
Blood
3210
Blood
3271
Blood
3272
Blood
3273
Be* la
EXPOSOBE ROUTE
Ingest Ion
Ingestlon
Ingest Ion
Hitmen.
inioD
QC
oc
TIC
oc
BOBBER
OP CUES
1
1) 27
b) 2»
c| 25
d| 20
231
al 32
b| 30
9
EaRGE
lot applicable
.
a) 0.03-3.70 ag/dl
b) 0.02-16.3 sg/dl
c) 0.03-2.0 ig/dl
d) 0.01-0.15 eg/dl
..
0.01-53.3 og/ll
a) 0.4-22.0 09/9
b) 0.3-50.0 «g/g
0.04-2.70 19/100 9
HEM
1.0 ng/al
at 0.77 ag/dl
b) 1.25 ga/41
c» 0.55 ag/dl
d) 0.05 19/dl
5.1 ug/al
a) 3.71 ag/g
b| 3.89 «g/g
lot gl»«n
GEIEB1L IIPOR!I»TTOI
d-bcaaphanlcaalne, a-iioephadrlw,
(copairplxiK, alcohol
l«T«la of nocpropoxyphcna also
a tillable.
'-'. it old »blt« feiale.
IICOHOLS; imcOTICS; D50GS; BLOOD;
DRIIEt BBall; LITER; UTIDIPiESSITE
tSEITS; COlItCTICOT; DRUG IBOSB; CaSE
BISTORIES
a) ftcat« vipoaucvs anc«lat«d to drag
ttamt
b| Ocag abas* cans
cj Ca«« of death anknovo
d) Ioa-pcopoiyph«n« related deaths
Batabollte gecpcopoxyphene levels
also available.
115 aedical e«aatnec cases in
Bacjland doring 1971-1976.
CROGSj DROG HOSE: MSI BISTCBIES;
eiOOO; BRall; tITIR; KIDREIS;
BIRILalD
Death caused by drag cosblnatlons
lecocds of 123t deaths la a. S.
Canada. la all, dlaxepae oc Its
setabollte nece pceseat la the
tlisaes and, la sast cases, tore than
one dcng vas foaod. ftgss: lass than
S-gceatet than 65 yc. High frequency
of selclde. other data available.
Palsonary and visceral congestion
aost cosaoa costsortes finding
DROG3; OROG HOSE; CtltDl; OIITEO
STaTISi OTIS; SBDaTIVESi BTPtOTICS;
fStCHOTROPIC OROGS; B1OOD; tlVBB;
IIDRBIS: ILCOBOLIC BCTERIGES;
IORERSIC BBDICIRB
a) DextropEopoxyphene
b| lorpropoxyphene (eetabollte)
Intopsles of subjects aged 16-75 yc
•ho died teas deitcoproiyphene
pclsonlng.
OROGS: BLOOD; SOSCIBS; 1ITBR; Oil IB;
CISB BISTORIIS; COBP»R»TI»B
ETaLOaTIOIS; aOTOPSZES; DBIHIRK
Selected cas«s--hlghest levels
occacced In overdosing and drag abas*
cases. Hetebollte norpropoxyphene
levels also available.
DRDOS; DROG 1BOSB; C»SB HISTORIES:
B1000: BiaiR; LITIR: (IDIBTSi
IIITLalD
BEFBREHCE
Baselt, P.c.
Shaskan, E.
Gross, E. S.
1977
caplan. I.H.
Thoapson, B.C.
Fisher, R.s.
1977
Flnkle, B.S.
HcCloskey, K.L.
Goodsan, I. S.
1979
.
Chrlstensen, B.
1977
.
capita, I.H.
Tbonpson, B.C.
rUker, R.S.
1977
-
(•BIT P1GE)
Ln
00
00
-------
2-Batual, *-(dlMtkrlaBlBel-3-Betkyl-1,2-AipheByl-, propioaate (eater). (2S.31)- (8 CI)
BramcMthuol. alpfc*r(2-(diBBtkyU«lBO)-1-Betkylet»yl)-alpk«-pbeByl-. propanoate (eater). (S-(B».S»)|- (9 CI)
«<9-«2-5
C22-B29-I-02
•I 339.«S, It 75-76 C
(COirllOBD)
TISSBI
3274
lidaey
3275
liter
3276
Liver
3277
liter
3278
8B*cle
3279
oclne
BIPOSBU BOOT!
lagestloa
ingestloa
IBgeatloB
-
Ingeotloa
lagestloa
IIILTTICIL
BBTHOD
ac
oc
ec
oc
tic
oc
nc
i
ac
TLC
IDBBBI
OP CISIS
9
1
9
33
B) 26
b) 22
. -
21
UISE
0.07-20.8 Bg/100 g
..
lot applicable
0.02-24.0 eg/100 g
a) 8.0-162.0 «g/g
b) 2.2-99.0 Bg/g
a) 0.7-53 Bg/g
b) 0.6-12.0 ag/g
a) 0.7-105.0 ag/g
b) 0.3-195.0 ag/g
BBII
lot gltea
19 ag/g
•at gltea
a) 5». 32 ag/g
b) 28.92 Bg/g
a) 5.8 ag/g
b) 3.01 ag/g
a) 15.19 ag/g
b| 32.09 ag/g
GliniL IIPOIIITXOI
Selected can klatcclea—klgbatt
letel* occurred la oterdoslag Bad
drag abaee cases. Ret aba lit*
Borprapozypkeae letel* al«o
DI09S; DIOO IIOSI; CISI BISTCIIIS;
BIOOD; BIIII: LXfll; KIDIBTS;
(IITLIID
fatal overdose froi tranylcyrroalna.
(Eopozypkeae, alcohol
letel* ot aorpropozypkeae alao
available.
55 yr aid «klte fesale.
IICOROLS; IIKOTXCS; 01003; ELOOD;
OIIIB; BIIXI; LXtEl; IBTIDBPFBSSITB
i«ins: coiiBcricot: DIOO iicsl; CISB
IXSTOIIIS
Selected caa* hlatcrles — hlgbeit
levels occurred la oterdoelag aad
drag abase cases, letabollt*
aorpropezypkeae letels also
available.
HOBS; DRUG IBOSB; CISB HISTC1IES;
BIOOB; BIIII; LXTBB: KIDIBTS;
III Till B
a) Deztropropozypkeae
t) lorpropozypkene (setabollte)
latopsles of subjects aged 18-75 yr
«io died frci deztroprozypkeae
polsoalag.
DI08S; BLOOD; BOSCLBS; LITER ( ORIIS;
CISI RISTOIIIS; COBPIRITITB
niLOITIOIS; IOTOPSIES; DBHIII
a) Deztroprofozypheae
e| lorprapozypheae (aetabollte)
latopsles at sebjects aged 16- '5 yr
•ko died froi deztroprozypkeee
colaonlng.
01003; BLOOD; BOSCLBS; LITIB; OIIIE;
CISB BISTORIES; COIPIIITITB
ETILOITIOIS; lOTOPSIBSi DBIHUIt
a) Deztroprorozypkeae
t) lorpropozypkeae (aetabollta)
latopsles of sabjects aged 1S-7S yr
•ho died froi deztroprozyphena
(Olsoalag.
CROUS; BLOOD; IOSCLIS; LITER; ORIIE;
CISI NISTOIIIS; COB?IRITITE
ETILDkTIOIS; IOTOPSIES; DERBIRK
REFBIEICE
C apian, T.R.
ThoapeOD, B.C.
Plsker, I.S.
1977
Basel t, R.C.
Sbaskaa. B.
Sross, B.B.
1977
caplaa. T.I.
TkospsoB, B.C.
Plsker, I.S.
1977
Cbrlsteasen, E.
1977
Chrlsteasea, R.
1977
Ckristeasen. u.
1977
00
VO
-------
591-78-8
CS-B12-0
91 100.16. BP 127 C
TISSOB
32*0
Blood,
3281
Heine
BinsOBE BOOTB
Inkalatlot
Derail
IBILRICIL
BETBOD
OC
-
Sadlontrr
BDBBBB
OP CASES
3
2
UME
•I Bot given
b) Bot given
•) Bot applicable
b) Bot applicable
HNB
a) 0.77 «g/il
b) 0.02 og/al
al 7,«70 dpi
b) C.590 dpi
GBIEBkL IBPOBBkTIOB
a) Before eipoenre of 100 ppi
t] kfter eipomce ct 140 ppa
folmteere 22-53 yr of aqe.
flmBOLISK; RETaBOLITES: OBIfE; BLOOD
SIROB: BBOBOLOniC BIIIPESTtTIOBS
•1 sabject 1
b) Subject 2
12-kc excretion of radioactivity
aftec 20 aCi [1-C1*]flnBX *ltk 15 il
BnBk.
foliinteeca 30-53 11 of age.
BIHBOtlSH! BRIBOIITESi OBI IE; BLOOD
Slltt; BEOB010GIC H»1I»BST»T10»S
BEFEIEfCE
Dirlncenzo, G.O.
Haiilton, n.l.
Kaplan, C.J.
1978
Difineenzo, G. D.
Baellton, B.L.
Kaplan, C.J.
KciMvage. l.J.
O'Donoghae, J.I.
1978
VO
O
-------
2-lapktkao»«cacboxa»J.aav «-»liB«tkrlaeino|-1,a.«a.S.Sa,6,11.12a-octafcTdeo-3.S.10,12,12a-paatakT4eoxy-6-aotkTl-1.il -dloxo (B CI) (T»l)
2-Bapkthaoaaocacboxaaiaa. a--, («s-(«alpha.aaalpha.Ulpka.5aalpha.6alpha.12aalpha)|- («
CXI
S6«-2S-0
C22-I2«-«2-OB
TISSOB
3282
•load.
MCU
3283
KdoMtrl
91
328*
o»acf
3281
OrlKct
3286
Ot*r»
Biroson nm
Injcetioi
iBjectioa
Inject loi
InJectloB
Injection
miRXCIL
•moo
Blccoblologlcal
Uccoblological
Biccoblologica 1
Rlecoblologlcal
Rlecoblologic*!
BOBBBI
OF CUBS
20
13
11
11
20
ItlOl
2.1-13.1 ig/il
2. 5-10. « tq/g
2.9-6.0 ig/g
2.7-7. » «g/5
•) 2.1-7.3 ««/g
b) 1.9-8.1 ag/g
nil
6.* ag/il
6.3 ag/g
3.5 «g/g
».l «g/g
•) ».0 «g/g
b) ». 1 ag/g
GBIIUL IBfOBUTIOB
Sacglcil ipaclnu. <0.75-«.25 he
•ft«c 200 ig, IT.
•!«t«c«ctoiy p«tl«Bt«. ig<« 25-C6
IE'
DlOSSi 01 00 TBBB1PT] IRIBIOnCS)
OTUIBSI OftDOCTi OTBIOS; IttTtllDl
HOOD SBIOB
Sacgtdl lp«clH» 1-3.5 he ift«r 200
•g. XT.
BT«t*ractOBT p«ti«nt«. lg«« 25-«6
It.
DBOBSj 0100 TRBBiri; IWIIBIOnCS;
CTI1IBS; OTIDOCTi OTBIOS; RliTUID;
BIOOD SBBOB
Sirglctl ap«cli«n«. 0.75-3.5 he «ft«r
200 mg. If.
B?*t*c«cto«r p*ti«nt«. tg«a 25-66
ie-
OIOOS; DSOO TREItPTi IBTIBXOIICS;
OVIIIBS; OTIDOCT; OTB10S; B1ITLUO;
BIOOD SBPOB
S«gtc*l •piciicni, 0.75-3.5 hr «(t«c
li(a«loB of 200 •«, IT.
BI«t*r*ctai} patl«nt«. tg«> 25-66
II-
OBOOS; DB06 THBBIPIj 1WIBIOHCS;
CTIIIBS; OTIDKT; OtBBOSi BklTLtBD;
BtOOD SBBOH
•) Cervix. r«ao««4 0.15-*. 25 he *ft*r
300 ig. IT
b) HroMtclai. cMOf*d 0.75-4.25 he
«ft«r 200 «g. IT.
B|«t*c«ctoiT p*ti«Dts. lg«« 25-66
ie.
tlOOSl OBOO TBXBAPT; UTIBIOIICS:
CTtBIES; OTIDOCT; OTBBOS; HlfTUID;
it 000 3BBOB
BZFBBBICB
•h«ltoa, A.
BllBCO, i.J.
CBCt«c, e.8.
Ccalg, T.J.
BeyBBt. B.H.
B«rb«t, D.T.
ling, T.B.
1979
Bh«UOB. 1.
Bluca, 1.3.
cactw, e.6.
CcBlg. T.J.
BcrBBt. a.a.
B«rbrt, D.T.
(lag. T.R.
1979
Bh«ltOB. 4.
BltBCO, I J.
Carter, 66.
Ccalg, T.J.
BCTBBt, R R.
B«rb«t, D T.
KiBg. T.B
1979
IhlltOD. I.
Bl»nco, L.J.
Ctctac, G.6.
Ccalg, T.J.
BCT*nt, H.B.
Ractat, D.T.
Klag, T.B.
1979
lhaltoB. I.
Blasco, L.J.
cactac, 6.6.
Ccalg, T.J.
BcTaat, B.B.
Racbct, D.T.
King. T.H.
1979
VO
-------
*-I«pktk*l«M
2-4Bftrtfetlm
• 23*.2«. n
rtssn
~
•rovtic icU, *-•
1SS. J C
IJMJ •!>>• ••tfcyl- .
1BU.TTKU.
•ran
DIC
i»i - i» tu
is- n en
or ciss
ti
E1VGZ
•1 *^. 3-^.1 v^^Bl
M JS-'-W. 1 •«/•!
BUI
•I W-t ««/ml
kl •! . 1 «9/»l
•1 Vittavt ••rfani tr»»r»«it
tl tft«c 5-" •« urnxv* 2X/S.T. 1»
nrfariK. *MM~ 4i;f«r«t. Kt.CZ.
•ccml wlcs. • (kit*!. 2 klickm.
oves: M*C ICTEBMTIOI: BLOO zns
CCmB&TITV RKLSkllHS
HL-! »W •
i»T. :-'
Jai«. 1.
9c4*toa. *.;-
-------
s-py«c»*f»««tyn-3-»-t.oiTi- ff en
s-HgT-i->- t>-»«t*yif»»TH - r* cxi
MM
imirrxcu.
CtSCS
•1 !-»-«-•«• «•/•!
•.3 kr
. 1.S B^tA at
. 1.
•». Initial
, 3 ••/•! at •.! he
tMU« Cna *a*k.
n-25 fr, fmil «
rti tsnrs: r»«ci;
. t.
trl. B-S.
Ln
to
U)
-------
2-Plp«cldlMMtkanol, alpka-(3,»-dlkTdro«Tpli«nfl|-,
1.2-B«M«Mliol. «-(h7droxT-J-plp»cidlnrla»lkrl)-. (I
329SJ-89-2
C12-117-I-03
II 223.2*. IP 203-20* C (crystal* team «tkrl ac«t«t*l
*' I" CD
- (9 CI|
TISSOl
32«0
Blood.
3291
OrlB*
iiposmt ton*
Ingastlon
Inkalatlon
T a Action
Inhalation
Inj*ctloB
HaLTTICaL
lETIOD
ladloaatrr
IOB881
OP C»SBS
b| •
cl 2
bl •
el 2
mot
•1 210.0-39S.O nl
b) 8.7-28.1 Bl
c) 9.9-18.7 nl
a) 36.9-50.3%
b) 19. «-62. 3S
c) 92.*-92.S«
mi
a| 230.2 al
b| lot 9lT«n
e) lot glran
M «3.9«
c) 92."«5t
GCIEBlL IlfOPSATIOM
a) 9.3-10 iq dos*
b| 0. 39-0.56 aq dos*
c) 0.038-0.22 B9 dos*
E*ak l«»«ls of cadioactiT* lab*l.
aipcasssd as •qal>al*nts of drag.
•stkaatlc hospital patlants.
CI05S; BLOOD PLaSBi: OIIIZ; IOTOIOHIC
CtOQS; 080C TBIBIPT
a) Dos* 1.3-10.0 sg
bl Dos* 0.39-0.56 mg
cl Dos* O.Ot-0.2 mg
P*cc*nt of dos* *xcc*t*d as (r«*
clsit*col and a*tabollt*s.
Istksatlc kospltal patl*nts.
D100S; BLOOD PLISHa; Olllt; IOTOIOBIC
DIORS; DBOG 1IHAPT
nmtrcr
Brans, I.E.
Sk*nfl*ld, G.n.
Thosas, I.
faUac. S.t.
Pat*rson, J.R.
197*
Eons, a.E.
Sh*n(l*ld, G.H.
Thosas, 1.
lalkat, S.R.
PatcrsoB, J.w.
-------
2-Fropuol. 1-
-------
2-?ropanol. l-(lsopropylaalnc)-3-(1-naphthylo
-------
2-Propanol. 1-o)-3-(1-»phtk«l«BTloxrl- I' CX)
525-66-6
C16-I21-I-02
It 259.3*. ft 96 C
ICORIITOD)
TTSSII
3291
BlOOfl.
plant
3299
Blood,
aaraa
3300
Orlna
Eiposgu loots
lB9a>tlOB
iMLmcaL
8BNOO
gc
oc
OC/BS
IOBBII
or CISBS
25
s
15
11IOE
•I 16-107 og/1
b) 10-*B «9/l
4) 56-281 ng/al
b) 5-31 ng/al
c) 0
a) lot gltan
b) 3-12X of dally doaa
_ . , ^.j.
•I lot applicable
b) lot applicable
a) 185 ng/al
b) 18. 6 ng/al
c) 0
•) IS of ill IT dome
b) 8« of dally don
OBIIHL inOIIITIOl
•1 Otily doae divided by 3. taken
ilth •«•!•
b) D«lly do«< takm at br«»k(««t
*•!«•• cormpOBd to dally de«« rang*
of 120-tBO 19 and ««n a«a*and
bofor* th« aonlag do««. a-w
IndlTidaali p*c AOM !•«•!. Otacc
data avallabl*.
tati«t> ulta ••••Btlal hyp«rtLOATIO«S; ALCCHOLS;
C100D PlaSBl
1BFBBEICB
fan das Brink G.
Boar, P.
Tan iatan, p.
Dorhoat Ba*a, B. J.
Qayakaa, G.G.
1980
Krlatanaan, B.o.
Stalnaaa, B.
laaka, J.
1978
lalla, T.
Conradl, B.C.
Valla, O.K.
ragan, T.c.
Gaff nay, T.I.
1990
Ui
-------
2-Propanol, 1-(tart-batylaslDO)-3-((a-aorphollno-1,2,$-thiadlatol-3-yl)osy)-, (S|-(-)- (8 CI)
2-Ptopuol. 1-H1.1-dlaethylethyl|aaino)-3-((t-(a-BOrpholinyl|-1,2,5-thladla*ol-3-yl)oxy)-. (
26839—75-8
CU-«2»-»«-03-S
II 316.»7
TTSSOB
3301
Blood,
plassa
..
3302
Blood.
plant
3303
Blood.
Serea
BXP030BB BOOtB
Tngestlon
Periocttlar
Ingeatlon
_
HUtTTTCM
RETBOD
OC-EC
GC-BC
OC-BC
-
IOK8ER
OF CISBS
4
11
19
BkBOE
t) 11.5-t. » ng/el
b) 7.0-20.6 ng/el
c) 12-52 ng/al
<2-9.6 ng/el
•I 28.2-129.3 ng/ll
b) 0-12.6 ng/al
cl ••.8-125.0 09/11
4) 0-5.6 09/1!
BEtB
•) 15.1 • or - 3.6
ng /ol
b) 3J.5 • or - 3.«
el 53.7 • or - 7.«
ng/el
•ot ippllcablo
*) 73.2 09/1!
b) 3.9 09/1!
el 72.7 ng/al
4) 1. « 09/0!
Glimt I«FO>HTIO«
• I 5 «2 ng/al) . Ooao cocroctod
for loas«a at th« tla« of
application.
H«althr aaloi
ladac«d Intraocalat praaaaco, loiar
pals* rata, ajstollc pr«a«ar«. and
aiaccls* tachycardia. Local offacta:
occasional raddanlog, tearing and
stinging.
DBOGS: BLOOD PL»SH»; DUIKE; BBaLTH
BIZ18DS; BtCOD PBESSOB!:
IITIHTPERTEISITE IGEITS
a) Poak after 1 he. noraal »clanteeta
t| Blnlaaa at 24 he, noraal
tclan tears
c) Peak after 1.5 he, aoderate
chronic renal Insufficiency catlenta
d) Dlnlaua after 2* hr. aodeute
chronic renal Inaufflclency (atleata
Identical reialta obtained fcr blood
plaaaa. 20 ag dose alien 2 hr before
breakfast.
9 Patients froa Pennsylvania aged
21-66 yc> 10 no real nlanteers.
Bypotenslon and bradycardia daring
dialysis.
DIMS; BLOOD SEROB; SaLIVa; OIIR;
CISBISBS; RETaBOLISII; FBIISTlTlItt ;
BIOOD PLaSBl
BBFERKSCE
Ishlxakl, T.
Tanara, K.
oyaaa, r.
1978
ntfriee, n.B.
Loventhal, D.T.
Tobert, J.A.
Shirk, J.
Eidelson, B.
Cook. T.
Oneatl, G.
1980
Loventhal, D.T.
Pitone, J.8.
iff rise, B.B.
Shirk, J.
Busby, p.
Kie, K.E.
lancarrov, J.
Soartx, C.D.
Onesti, G.
197B
(IEIT P13B)
vo
00
-------
2-FCOpanol. 1-(tert-betylaslno)-3-«a-aorphoUno-1.2.5-thiadlaiol-3-yl|ory|-. (S)-(-J- (a CX|
2-Propanol, 1-{<1.1-diBethylethyl)aslaol-3-«»-es-aocpholiByl)-1.2.S-tkiadiaxol-3-yl)o«yl-. (3»- (9
2(839-75-8
C13-B2«-l*-03-3
II 31C.4T
(CORimiD)
fissn
330*
Saliva
3305
Ocine
3306
Orlne
3307
orine
BIPOSOIE BOOTI
tagestlon
Ingest Ion
_
lagestion
Perlocelar
alaLRXCaL
RBTBOD
OC-BC
OC-EC
GC-BC
OC-IC
lORBH
or CUBS
19
al 7
b) *
12
BMOI
at lot given
b) lot given
c) lot given
d) lot given
a) lot given
b| lot given
al lot given
b) lot given
c) lot given
lot given
nil
a) 62 ag/nl
bl 3.» ng/el
c) 103.* sg/sl
d) 2. «S ng/el
a) 13.11
bl 5.31
al is » or - 3% of
dose
b| 1« » or - 3t of
dose
c| 21 » or - 12* of
•6 ag
aEIEBIL IIPOIR1TIOI
a) Peak after 0.5 kr, norsal
volanteers
b| Rlnlsae after 12 kr. no real
volunteers
c) Peak after 2 kr, patient* nitk
sodacate ckconic renal insufficiency
d| Blnlsas after 13 br. patients vlth
soderate ckconic cenal InsnfUciency
Date extrapolated froe figices.
20-eg dose given 2 kr before
breakfast.
9 Patient* fros Pennsylvania vith
varying degree* of renal function.
aged 21-66 br, 10 noraal volenteecs.
Rypotenslon and bradycardia daring
dialysis.
DIOGS; BtOOD SEBOR; S»LI»l; OBIIE;
DISBaSBS; aiTIBOLISR; PBIISTITllXa;
BICOD PL1SRI
a) lorsal subjects, 18 kr excretion
of 20- eg tliolol dose
b| Patient* »lth aodecate chronic
cenal Insefficlency, «8 kr ereretlon
of 20- sq tlaolol dose.
patient* fros Pennsylvania vltk
varying degree* of renal function.
aged 21-66 yr.
Hypotension and bradycardia daring
dialysis.
DIOOS: BLOOD SBROR; SatlTa: OBIIE;
DISEaSBS; BMaBOLISR: PEIISTlTilla;
BIOOD PttSBa
a) 5 eg
bl 10 ag
c) 20 ag
21-hr nrlne values after single doses
of ssleate.
Realtky volunteers, 20-21 yc old.
DHOIS; DB06 TRBRaPY; BIOOD PUSRl;
0«r»E: CORPIIaTIfS BMLHaTIOIS
0-12 he cusulatlve eiccetlon day 1
after about 600 ug. 0-8 kr
excretions not different on days 1
atd 5.
Realtky aales
•educed intraocular pressure, lover
pulse rate, systolic pressure, and
exercise tachycardia, local effects:
occasional reddening, tearing and
stinging.
DBOGS; BLOOD PUSH; OIIRE; BMLTH
RltlBDS; 8LOCC PBESSORB:
»TIRT?»TcISIVE IGEVTS
IBTBBBIO!
Loventkal, D.T.
Pi tone, J.R.
If trine, B.B.
Sklck, J.
Busby, p.
Kll, K.B.
lancarro*. J.
svactx, C.D.
Onestl. G.
1978
loventhal. D.T.
PI tone, J.H.
Iff rise, R.B.
Skirk. J.
Ba*by. P.
Kle. s.B.
lancarron, J.
Ssartx, C.D.
Onestl, c.
1978
Ishlxskl. T.
Tavaca, K.
Oyaaa, T.
lakaya, B.
H-'R
affriae, B.B.
toventhal, D.T.
Tobert, J.i.
Shirk. J.
Eldelson, B.
cook, T.
Onestl, G.
1980
Ln
vo
vo
-------
2-Propanol, !-(«-(J-i«thoir<> thyl) phenoiTl -3-((1-n«thylethyl| aiino)-. (»-)-
31350-58-6
C15-B25-R-03
HR 267.38
TISSUE
3308
Blood.
plain
RIFOSORB BOIJTR
IngestIon
HIULTTICH.
ntTHOD
IORBBR
Of CASK
30
RIRGR
a) 0.2«-1.03 ag/il
b) 0.06-0.35 ug/«l
c) 0-0.18 u9/il
d) 0-0.016
•I O.SS a«/il
b) 0.19 «f/il
c) O.OS U9/il
d) 0.006 ug/«l
•) *ft«c I «t on 300 >q/dar> 1"2 ''
Aft«C dOS«
b) >ft«c « «k on ISO eg/dar, 1-2 he
a(t*c dos«
c) >tt«c H «k on 300 aq/day. 26 he
attar dos*
d) »ft«c 8 «k on 1^0 ig/dar. 26 he
after do»«.
ratUnts, aqw 33-60 jt, «ltt pclaacy
>Tp*rt«n>lon and nocaal hepatic and
ranal function.
Lower blood pcessiice« heart tato, and
plaaia renin activity. Reduced
orinarr aldosterone. Soae, aheexing
and ehoctnese of bceath, fatigue,
Iniocnla, lenstrnal disturbances.
CROUS; DROG TBEE1PI; HTPERTEISIO';
BICOD PltSHt; BLOOD PBBSSOBE; SVEDEH;
CIRDIOTtSCOLtR DISUSES; BEkET
CISttSES
BEFEHEHCB
Xarlberg. B.C.
Nilsson, O.
Tolagen, K.
Rltellos, t.
•aern, 0.
1979
O
O
-------
2-rcopaiol, 1.1.1-trlehloro-2-Mthrl-
S7-t5-8
C«-«7-a3-0
Bl 117.47, » 97 C (aahTdroai) , »P 167 c at 760 » lg
Ttssni
3309
Blood.
pluu
EIF0301B EOOTB
IngMtion
tllLTTIClL
RETROD
OC
IDRREI
OF CIS IS
1
11ME
100-50 ag/»l
nil
75 ug/»l
GEIEIIl lErolBKZOI
D«clin« one 13 4«i*. S«t« ef
dtcLU* •xpoa*Dtltl *nA caiptrabl* to
ecntcol*. l«tlBat«d fcoi graph.
«0 rr oia ••!• tilth hl«tory cf
alcohollai. bat not foe p«»t 7 jr.
B*gan taking lacE«a*lng do*«a of drag
3 to bvfon iililulon.
Cco««in«», «lo« apMctt. dfiarthrla,
•lagglsh r«fl*x««
SOH ««raa «ixra«« «l«Tat«d.
ld«aocareln»a infiltrating line.
DBOOS; DtOG IBOS8; SBOlTITESl
lOSnaLIai lODlTSi BIOICCORDIITIOI:
HOOD PLlSRIi CORPIItTITE
ITtLOlTIOlS: EllTBBS; RBTlBOUSli
inioLooic RiixrisiiTiois;
PSICBOTIOPIC DBOOS
BirasncB
Borody, T.
Chlnvak. P. B.
Orahai, O.G.
lad*, D.I.
llUlau. K.H.
1979
-------
7-Pcopcn-1-aii.il*, 3-(«-broaothenyl) -l,l-dUethyl-3- (3-prrldlnrl)-, m-
56T75-IIB-3
C16-H17-BF-I2
11 3n.25
TISSUE
3310
Blood.
plant
3311
Blood,
plaaaa
SIPOS01E 10HTI
Ingest Ion
Ingestloe
Injection
allLTTICKl
KETBOD
BPtC
- -,-^«—
cc
IOHBEI
or casBs
IS
«
lafSE
a) Rot given
b| lot given
e) lot given
1) lot given
•) 13- 2 a 20 oaol/1
a) lot given
b) lot given
c| lot given
d) lot gives
•) lot given
f) lot given
_
IIEtl
al «02 » or - 62
DIOl/1
b) 630 » oc - 160
oaol/1
c) 5J» » or - 97
niol/1
d| 15) • or - 68
naol/1
•1 lot gl*«n
a) 56 ng/il
b) 3.4 ng/«l
c| 60 ng/al
d) S ng/«l
•) 38 ng/*l
() 19 ng/kl
CEIIItt, IIFOBMTIOI
a) 1 nit
t( 2 «k
c) a «k
4) 6 ok
•) Vang* of Indlvldaal »»la«a, first
>««k •xclodcd
a)-d) rang* of »aoa
Ocm, 200 ig/dav, 6 vk.
•dalt ln-patl«nt» nitli pcltatr
d«pc«««l
Borg, K.-O.
Johasson, R.
Jordo, I.
Lendborg, P.
Ponn, 0.
lelln-Pogelberg, I.
1979
O
ro
-------
2,3-Dibroaop ropaaol (lo poitlaga in CBERLIIB).
Bl 217.40. at 219 C (alight Aaeoap)
nssra
3312
Ocll*
BXPOSOBB BODTB
iBUTTicu
BBTBOD
as
IOBBBB
or CISBS
•I e
b) 1
Cl 1
•HOB
•1 0.5-5.0 ig/il
b) lot appllabl*
e) 11-29 »g/il
ran
•I lot glna
b) tr«c«
e) 19. ( nj/«l
8BIBB1L TITOIUTIOI
-
•) CklUcai Miring ««ih«d.
trl>-BP-ti;»t«i slMpiwic
b) CkiU - 6 BODth* after c«Mation
of nariig trl«-BP-tr»«t«4 ptjuu
c) T-yr-oia •••ctof n«>
tri«-BP-tr»«t«4 pajaui
OBIiB; RBTHOLISII B BOBI IB OMtBTC
CCIMOIDS; I1COBOLS
-
1E1
BlH, ».
Gold. B.D
AMI, B.B
Mayon. c
Jo«««, F.
Batt, B.I
Doagaarty
BocaUg. l
Dxtaic. I
Carroll. I
SUllmll
Tkaaot, J-
1978
•EBBId
.
B.C.
I.C.
I.I.
B.B.
•P.
ON
O
oo
-------
J.)-lk»kthkUM«iol, <-(J.tO. 1-l
kypoctokklok.
DIMS; iiooi rikstki H.OOP riissnt;
tVtltTttSIOt] Cktt)OTk9CtLkt
tXStkttS) AfttLTS] t&SSkCRVSIYTSi
ccm*»Tx*t n \LoiTtoi]
k| 10 kfStk)
k) 140 kf/4k;
c) lit k«/4k)
l*««kt«t pilot to toM ok 4k j« *• 11.
«, ». 1*.
Skb1*cta iltk oaavktlkl kTr*ct«k*lOk.
CoitvtktlOk, c«-0. k*. k*t«**t
kt«k4}-*tkt* MC«k !•»•! kk4 t
4»cr*kn Ik mplk* tlkatolic
[(•••tit*. »<0.tt.
II BOS l BUS TltUMi RTMITieiOll
HOOD St»tt| COItkUTXTt tTkttkTTOIS;
MCOO tltSStlt
isrtiiict
follcwr. L.
Ukk«, C.S.
Ck*tk«. H.
titft. c.r.
I»t«kk«. «.l.
Gavrks, t.
Rrtffltk. D.L.
Tokonck, *.
Vtkniwt* I.K.
1«1«
DVCklk. «.l.
Tkkovlck. «.v.
Dwiklek. i.e.
ecooi. J-T.
*llUr«. D.I.
1*t»
-------
iM«l«M. J.J-«l««kyl-S-«»tkyl-
>
•I UJ.M. •» f*-T> C
rtssn —
3311
U«oi
•xtosm MTO
klUTTICU
•mo*
OP CkSB
11
UMt
- -
-
•H.I *t/»l
_...,-
cinui iitMinioi
..
D*«tk »«••< ky 4r«t co«bi««Uo«a
CraUa. IB all. «iai*|aa ec Ita
Ht*bollt« ««n pr*««*t IB tk>
1fi«at«c tkaa *S ft. U«* tt«fi»«cy
of mlcl«*. Otk%c teta avallabla.
talBoaarf ••* *lac«ral coaoMtiom
•Mt eoaBoa roataort** tlaiti*
••MS; MM kllSI; CklkBkt BUTM
s«tis; iTkii stutntsj itrnTics:
isTCicrtoric MOSS: uooo; Liru:
I16UTS; klCQIOLIC HVKKkQIS)
retnstc IIBKIII
uritnct
«ao*a*B. l.S.
O
in
-------
,
110-13-*
C6-110-02
HI 11*.1*. Bf IBS C
TX5SOB
3116
float.
MC«a
BIFOSOBB BOOTB
Inhalation
. - _.
llaLTTXCIL
HBTCOD
OC
-
IORBBI
OF CISBS
3
lalOB
.
a) lot applicable
b) lot tppllcabl*
c) lot applicable
d) lot applicable
mil
a) 2.0 ng/il
bl 3.0 uo/il
c) 0.1 oq/al
d| 0.2 09/1!
GtllBIL IIPOSIiTIOl
a) 0.5 ac folloloq «po>ur* to SO
ffa HaBK
b) 3 kc (ollonlig •ipoauc* te SO ppa
IBBI
e) O.S kr following enpoaar* to 100
fft IDIK
4) 3 he following •ipo«ac« tc 100 ppa
laBK
HItlBOLISR: RRaBOIITCS; OlIIBl BLOOD
StfOI; IIOIOIOGIC BIIIPBST4TIOIS
REfEBEUCE
DlTlnccaxo. G.D.
Baitlton. N.L.
Kaplan, C.J.
Krasarag*, ».J.
O' Donoghne, J. L.
1978
-------
359-83-1
C19-B27-I-O
n 285. M, 81 1«5.«-1«7.2 c (ccjatkU ten Mtk»ol tad »«t»r)
nssiii
3317
Blood
•xfosoiB iom
iniRicu.
BBTBOD
•DIBII
OF CiSIS
1
UKI
lot applicable
_
Ull
0.2 B9/100 11
BIIIUl IROIBHIOI
-
B«dtetl «ailn*c CUM of d«ttha f ro«
lat«itlo»l oc *cci4nt»l 00. or
•id«t«cilMd oc nitoril e«u«.
01 DOS I 1DTOPSIKS; WPBlIBIIBSj
SOICIDB: BLOOD; OIIII; LITI1; BILB;
ClOa tBDSZ
•minn
Sl«k. T.J.
1978
.
0\
o
-------
j,7- (Bpoxypantad*ca( 1,11,13) tr lenlalno) ntphtho (2.1-b| fnraa-1,11 (2H) -dione.
5.6,9.17.19,J1-he*ahydro*f-23-Bethoty-2.a,12,1«, 18,20. 22-hepta«ethrl-8-(»-l<
patient*. «ti«n c«|;«*t«A la 2
patl«nt«, lonccinq of peak b)
breakfast not castalned.
18 patients, 11 aale and 7 fraale,
lf«d 18 to 66 re.
OIOOS; TOBEBCOLOSIS; RLOOO SIHOS;
OBIlt; 4ITIBIOTICS
a) Peak, (00 ag after fastin9
t| Peak. 600 ag 30 ain after high-fat
tceaktast
letive paleoaacr tabercnloaia
patient*, falaes ace 2«-hr total.
18 patients, 11 ule and 7 faaale,
aged 18 to 66 ft.
DIQGS: TOBBICOLOSIS: BLOOD SIIOH:
OFIU; UTItlOTICS
REFEIMCE
Sle9l*c, D.I.
Barley. D.I.
Bryant, fl.
Citron, K.n.
Standen, s.n.
-
Slegler, D.I.
Barley, O.K.
Bryant, n.
Citron. K.n.
Standen, s. 9.
I97a
O
00
-------
2'.6<-acetoiTllUd«, 3-{dletbyla«i»o)- (8 CI]
icetaeld*, 2-aglaal blrthe.
'
Ceaaceaa births.
D100S; DIOG TBIlaPT; tBBSTBBnCS;
BITlBOltSB; BBTiBOLITBS; BIOCD
PlaSBa; IEBBOBI; OBItl; OBBIUCU
CCBD
„
a) Peak 0.25 hr after 1 ag/kg IT
b) * he aftec 1 ag/kg IT
Bealthy Canadian volunteer* aita
average velgbt of 59.1* kg.
010GS: BLOOD PLaSBk; HEaSOBBBBBT
BItHODS; CIBtDt
a) Lldocaina, ceaaceani
e) Lldocalne. raglnal dell»eclea
c) aoBoeihylglyclneiylldlde,
ceaaeeaBS
d) Bonoethylglyclneiylldlde, Taglnal
dallTeclea
e) Qlyclneiylldlde, cesareani
fl Olyclneiylldide, vaginal
dellferlea
Talaes aftec lldecalne by epldacal
catheter.
loraal pcegnant patient*.
DBOUS; OBOO TBBIaPIi aBBSTBHICS;
BETaBOLISH; BETkBOltTBS; BLOCD
PlaSBa; lEIBCRi; OitlB; OBBIUCU
COID
a) Therapeutic peak levels, 30-60 Bin
a (tec dose
t) Range of aeana, 0 and 90 iln after
dose
Itecage Initial doae, 1«1 ag.
Sabaeguent dcses, average of 7a eg.
Fatieats undergoing cardiac
alectcophyslologic stadias.
DIUGS; DIOG IHCfUPt; t'DIAlk; BLOOD;
CIBDIOTISCOIIB DISt>SE$: UtlFT
DISEASES
•BniBBCB
Taleatonr, J.c.
aggarial, T.
HcGee. B. P.
Gota. S.I.
1978
Itahnect, B.I.
KBapp, D.B.
Kuhnert, p. B.
Procaaska. t.L.
1979
Callle, G.
Lelorler. J.
tatoac, T.
Beaner, J.G.
1977
Kahnect, B.I.
KBapp, D.B.
Kahaect, P. a.
Pcochaska. l.L.
1979
lattel. S.
Riakenbarger. B. L.
Lehraaa, L.L.
Ilpes. D.P.
1979
-------
}',6'-lc«toiylldld«, 2-(dlctkrlaai.no)- (8 CI)
IcetaaUe, 2-{diathTUalao)-B-(2.6-dl»tkylpkeBrl.|- (9 CXI
137-58-6
C1I-I22-I2-0
HI 211.33, lit 68-69 C, a? 160-181 C «t • «• Bg. 159-160 C at 2 •• Bg
(com 10*0)
I TISSOV
3325
Line
3326
OtlM
BXFOSORK ROOT8
iBjactloa
llaimCiL
BITBOD
oc
DC
IOH BE I
OP cuts
1
33
IIMS
lot applicable
•I 5.9-0.2 noyag
ccaatiaiBa
b) 9-0.3 og/al craatlnlne
C) 4.2-0.7 ug/ig
oraatinin*
A) 1-0.2 ng/ig cr««t in in*
•) 1 •'.5-1.8 ag/ig
cr*ttiain«
f) 7.2-1.1 o9/«g
cc**tlnlB«
Dill
0.37 eg/100 g
*) lot applictbl*
b) lot appllctbl*
c) lot ippllctbl*
a\ lot tpplicabl*
•) lot appllctbl*
fl lot applicable
GCIIBIL Iir08B»TIO«
Cocaln«-c«lat (coi oracdoM
fatality Inrolrlag cocaln*.
DIQOSi DBTIIOLITESi lOTOPSIBSi BLOOD;
OKIB; «Ilt! BItXI; LIfEB; LOIOS
•) Lldoealn*, aotkcca
b) Hono»thylg
c| olyciaaxrlUiaa, aothaca
d) Lldocalna, aaoaataa
•others
aaonataa
oaonataa
Day 1 - Day 3 orlna, 1« aotbara. 19
naoaato*. lldocala* by apldoral
cathatac daring labor.
CIOGS; DBOO TREBlPt: UESTHBTICS;
BIT4BOLISB: BRABOUTES; BIOCO
PUSH*: inBOBi; .L.
1979
-------
2l-1.2-BeuotUa*l*e-3-eaEbOBi*lle. a-hjaroxy-2-aetkrl-l-2-prtiainrl-.
3022-90-*
C1S-I13-R3-04-3
•1 311.37
1.1-aioxia*
TXSSDI
3327
Blood.
plMia
- - -
•(MSOn HDTI
Ingection
tlURICU
RBTIOD
Ooloriaetrr
RO'RBBI
or ctsts
at 2
b) «
o| 5
e) 5
uiai
a) e
c) ictaritlc patient*, rang* of
•ean*, 0 ana « he after 10 *a. oral.
on a*r 1*
d) artkritic patiente. range of
••an*. 0 ana • hr after 20 *g. oral.
on an? 1*
el trtaritlc patient*, range of
••an*. 0 ana • hr after 30 a?, oral.
on 4«J 1*
Rcaltkr ••!•» ana patient! clth
rheoaatoia artkrlti*.
CIB03; DROG XRBIkPI; B100D PUSR1)
CORRBCIXCOT) MTI-IRFtlRHaTOR
iCEITS; IRI16RSICS; COHPiRHITB
IflLOHIORS; UOLTSi RRBVRITCID
II1RRITIS
imuncB
Hobb*. D.C.
noaay, T.R.
1979
-------
2B-t,2,«-B«ntotM»dl»lln«-7-nilfona«14e, 3,a-4ihydro-6-(trif luoroaothyl)-, 1.1-dioxld*
t35-09-l
C8-H8-F3-»3-0«-S2
HI 331.29. B» 272-273 C
TISSBH
3328
Blood.
pit Ma
BIPOSOBB HOOTB
Ingestion
iMinicii
HBTHOD
.
rlioroeetrr
ROBBER
Of CkSBS
12
B1BGB
0.05-0.0* ag/il
HEtl
0.32 og/»l
GEIIB1L IIFOBmTIOH
Range of 0.5- and 12-hr leans. Man
(teak nine at 2.3 he after single
100-ig dose. Zero-order absccption
rate.
Faalthr adults
CBOGS; aOOLTS; BLOOD PUSH*
aifEBEUCE
Rclaiaca, P.J-
Colbqcn. tf.l.
Gibaldi, B.
\9"'»
N3
-------
2B-1.2,»-B«oiotki«aiMiD«-7-«ilfom««H«, 6-ckloro-, 1.1-AloxU*
58-9«-«
C7-M-C1-I3-0»-S2
91 2n.1t, at 3*2.5-3*3 C (4«coip)
TISSUE
3329
snomi IOOIE
ing* it to*
_
IEILRICIL
DTIOD
Oolorlictcr
_
or CUES
12
E1E8E
10. 9-19. 7* of do«*
mi
Eat glT«n
«EEEUL IIPOBBWIOE
-- - - - -
Eing* at ••in* for 5, 250- oc SOO-ig
tibl*t-to» cklOEOtUixld* pmdoct*
ID 2«-kr •ciH*. CaiaUtlT*
•tcntlan b*gu to pl*t«« «t 1.5 he
Cac »H S predict*. g*iii«>
•icrctton «t 2.1-3.3 hr.
E«Utkr iabj«ct*, tgM 23-28 jt,
dated b«foc« and aftcc doa*.
CEOOS; BBTIBOLISB! OBI IE; »BOtTS;
COBPlEtTITE ITlLUtTIOIS
EBFBEEECB
straaghn, ».B.
B«Ukl». t.P.
B*nc, B.C.
1979
-------
2B-1,2,«-Benlothla1
b) *;o Bf/el
c) «28 ng/tl
4) 18 119/11
e) 2«
a) Subject 1, 3 he poet-lngeitloo
b) subject 2, 3 he post IngettIon
Btilthy rolanteeci
DB01S; BLOOD; BLOOD PLlSHa;
DIOIETICS: 5t»SO»tatIT HETBOCS; KE»
IOIX; »EW JtBSBT
•) Subject 1, 2 hr poat-lngeitlon
b) Subject 2, 2 he post-lngeitlon
c) Subject 1, 2-5 he post-lnoeition
d) Subject 1. 2* hr poat-ln
-------
2B-1, «-B«Bia4lBB«plB-2-OB«> 1, J-dlkydco-T-Bltro-S-pkcD yl-
116-22-S
C15-I11-B3-03
II 281.If, H 22«-226 C
fXSSBB
3332
Blood.
plBSBB
BXMSOBB BORB
Ing*«tlOB
1I1LY1ICIL
BB1B.OD
ge-BC
IOBBBB
or CUBS
11 "
b| 20
c) 6
BHOB
•) lot gl?*B
b) «-15 Bg/Bl
c) 68-21* ag/Bl
nil
•1 57 » or - 17 ng/Bl
b) «B » or - 20 Bg/Bl
o) 71 » or - 9 ag/Bl
CBI1HI XIMBBtrXOI
•1 TolaatMts OB t Bg/day
b| P«ti«nt« oa 5 ig/dBy, 10 Hlw. 10
C«al<«
c) P«tt«nt« OB Bor« tkaa S ig/day. 6
ititdy >t>t« VBlwi. I»t« o(
••tabolliB stable daring lOBf-t*r>
tbcrspy.
11 TalutMM IB good kwilth. *g«»
21-33 yc. 26 piyeklBtclc oat-p«tl«nt
iBiOBBlBcs, Bgra 21-59 yc. «11 of
TBckB. «o«t OB Bolti-dr«g therapy.
TOlUtMEBI dilXiBW, BOICl*
MlBXBtloa. dry BOttk. k«BdBck«, bad
dEwtBS. Bllotgie »ryth«B«. Pati«nt«
tindBBii, diniHM, BOW!*
«*BkB«SS. VirtlgO, BtBXlB.
Sld*-«ff«ct> »ri«d, BOB* »*iiou
•ic«pt *rytk*BB.
COBP»HTI»B BTiLOtTIOIS; OI06S; DR06
TBBBIPI; 0100 ABOSI; kDOLTS; PIIUID;
BtCOD PLISII; PSICBOTIOPIC D6003;
IIOIO108IC RIIIPBStHIOIS: RRlBOLISB
BBFBBBICB
(BBgBS, L.
(into, J.
L*ktlB*B. T.
SBlBiB«B. J.
1979
-------
2B-1,»-BenxodUxepin-2-on«, 7-chloro-1-(2-(dlethylaslno) ethyl)-5-(o-fluorophenyl|-1. 3-dlhydro- (8 CII
2B-1,«-BenxodlaxeplB-2-OBe. 7-chloro- 1-<2-(dlethylaalno)ethyl) -5- (2-(luorophenyl)-1. 3-dlhydro- (9 CI)
C21-B23-Cl-»-l3-0
II 387.89, BC Dihydrochlorlde 190-220 C
TISSOE
3333
Hood
333*
Blood.
plasaa
-
3135
Blood.
plasaa
ETPOSDBB ROOTS
'
Ingestloa
Ingest ion
AIALTTICAL
RETROD
OC
iBBUnoeniyaatlc
OC-BC
IOBBB1
or CASES
b) 1
c) 1
dl 1
10
BAIGE
0.1-210 ug/Bl
a) lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
e) lot applicable
a| 25-93 ng/Bl
b) 31-167 ng/il
c) 31-110 ng/Bl
d) 0-118 ng/al
RSAI
17.1 ag/il
a) 0.5 og/al
bl < 0.2 og/al
c) <0.2 ug/sl
d| 1.7 ug/sl
a) 6* ng/al
b) 103 ng/Bl
c) 122 ng/sl
d) 16 ag/al
GCIIBkL HFOBBATIOK
Death caused by drag coBbinations.
Becords of 1239 deaths in 0. s. and
Canada. In all, diazepae or its
setabollte »ere present in tte
tissues and. in Boat cases, tore than
one drug vas found. Ages: lass than
^-greater than 65 yr. nigh (regnsncy
of suicide. Other data available.
PulBonary and visceral congestion
aost cosson postsortea finding
DBOGS; DBOC ABOSB; CAIADA; OpTTBD
JUTES; OT1B; SEDATIVES; RTPtOTICS:
PSTCROTBOPIC DBOGS; BLOOD; LIVEB;
(IDIETS; IICOROLIC BEVEBA6ES;
FOBEISIC HEDICIIE
a) 71 yr old san, suicide
b) 27 yr old «osan
c) S yr old glcl, apileptic.
•ubtherapeutic levels of
dlphenylhydantoin also found
dl 54 yr old san, posttraoaatic
epilepsy, previous suicide attespt
a) 5» yr old san, depressive
syndrose, blcod alcohol level 2.98
All died of scute intoxicaticn tros
cosblBation of pheoobarbltal and
flaraxepae
Cata also available for sose
satabolltes.
Deep cos a, cardloclreolatorv
collapse, shock, cosplete araflexla.
Each case had 1 or Bore of the
following: polyvlsceral congestion.
cerebral injury, encephalic and
palBonary edesa, bronchial pcensonla.
hepatic cirrhosis.
ItOLTS; CBILDBBI; AOTOPSIES;
AITICOITOLSAITS: BIPBOTICS;
AITIDBPIBSSItE AGE ITS; BLOOD PLASBA;
BBAii; LDIGS; Kioins; LlfEl; OBIIB;
DBOGS; OIOG TBEBAPT; RBTABOLTTES;
SOICIDI; DB06 1BOSE; ITALY
a) 1st sornlng
b) 7th sorning
c| lath sorning
d) 7th aornlng of nashout period
l-Desalkylf luraiepas setabolite after
30-sg dose 30 Bin before bedtlse for
11 days.
Patients ulth severe insosnia but
free of soaatlc and psychiatric
illness, ages 21-36 yr.
sleep latency did not differ fros
placebo.
CI08S; DIDO TBEBaPl; BIPIOTICS;
SIDATIVES; CCBPABATIVE BTALOITIOIS;
ADOLTS; BLOOD PLASBA: IEOBOLCGIC
lAIIPBSTATIOISs BBALTI BASABCS;
OIAZBPaBS
P.EFEBEHCE
rlnkle, B.S.
Becloskey, K.L.
Coodsan, L.S.
1979
Ferrara, s.D.
Tedeschl, L.
Barlgo, B.
Castagna, F.
1979
Lisnolla, 1.
Er«ln, C.I.
Logue, P. E.
1980
-------
2l-1,e-MB*o41a«epla-2-on*. 7-ckloro-1-(2-(diethjlaelno)ethyl)-5-(o-fliiorophenyll-1.3-dihydro- (8 CI|
2B-1.a-BaaaadiaMpi»-2-oM. T-CBloro-1-<2-
-------
2H-1.a-aan«odla*epiB-2-oae, i-ckloro-1-(2-(dlotkylaBlBO|othyl| -S-(o-flaoropkenrl) -1, 3-dihrdro- (D
2B-1,«-Be»odla*epin-2-OBe, 7-chloro-1-(2-(dlothylaBlBO)etkyl)-S-(2-flaoroDheByl|-l. 3-dihrdro- (i
C21-H21-Cl-*-I3-0
HI 387.89, It Dlhrdrocklorlde 190-220 C
(COITIIOBD)
CI)
TISSOE
3331
Liver
3339
Lang
BXPOSaiE MOTE
IngestioB
UALTTICIL
HETBOD
OC
IssaBoeniveetic
OC
XsiaBosBiysatlc
IOBBBI
or CISBS
a) '
b)
c)
d|
e|
a)
bl
c)
d|
e|
lalOE
a| lot applicable
b| lot applicable
c) lot applicable
d) lot applicable
e) lot applicable
al lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
e) lot applicable
mat
a) 1.7 ag/g
bl 0.8 ag/g
c) 2.7 ag/g
d) <0.2 ag/g
e) 7.3 ag/g
a) O.B ag/g
b) 0.« ag/g
c) 1.9 ag/g
d) <0.2 ag/g
e) 1.8 ag/g
OBIIB1L IirOBBATIOl
<) 71 yr old ean, aulclde
t) 27 vr old voaan
c| 5 it old girl, epileptic.
aabtherapeatlc levels of
dlphenylhydentolB also foand
d) 5* yr old Baa. posttraueatic
epilepsy, previoos saicide attespt
e| fa yr old aan, depressive
svndroae, blood alcohol level 2.98
9/1
111 died of acute intoxication froa
cosblBBtlOB of phenobarbital and
Clara xepaa
Data also available for sose
aetabolites.
Deep coaa, cardloeircalatory
ecllapse, shock, coaplete araflexla.
Each case had 1 or sore of the
folloelng: polyvlsceral congestion.
cerebral injary, encephalic and
palsoaary edeea, bronchial pnaaeonla,
hepatic cirrhosis.
ICOLTS; CRILDIBI; IOTOPSIBSJ
IRICOIVOLSIRS; HIPIOTICS:
IITIOIPIISSIIE aOERS; BLOOD PL1S8I;
IIIII; LOIOS; KIDIETS; LIfEl; aUIB;
OlOaSt DB06 TBEIaPT: BETaBOLIIESt
SOICICB; 0106 IBOSB: IULT
a) 71 yr old aan, aaicide
t) 27 yr old vonan
c| 5 yr old girl, epileptic.
•abtherapeatlc levels of
diphenylhydantoin also foand
d) 5» yr old MB, pasttraaeaUc
epilepsy, previous salclde attespt
e) •>» yr old ean, depressive
syadrose. blood alcohol level 2.98
1/1
111 died of acate intoxlcatlcn froa
coablnatloa of phenobarbital and
tluraiepaa
tata also available for SOBS
aatabolltes.
Deep coaa, cardlocircalatory
collapse, shock, coaplete araflexla.
Each ease had 1 or sore of the
follonlag: polrvlacecal congestion.
cerebral lajary, encephalic and
calsoBary edeea, bconchial poaueonia.
kepatlc cirrhosis.
ICOLTS: CRZIDIBI; IDTOrSIBS;
IITICOITOLSIRS; BIPIOTICS:
IITIDBPIE9SIVE 10BBTS: BLOOD PLaSBI;
llall; LOieS; KXDIITS; LITE!; OIIIB;
DIOOSJ DSOB TBBIarTi HBTaBOtlTBS;
30ICIDE; DIOO IBOSEj ITalT
SBFEBEICE
Ferrara, S. D.
Tedeschi, L.
Barigo, a.
Castagna, F.
1979
rerrara, S. D.
Tedeschi, L.
Harlgo, a.
Castagna, F.
1979
CO
(HIT rial)
-------
2B-1.*-Baa«OUaieplB-2-OBe,
1761T-JJ-1
CJ1-B2J-C1-F-BJ-0
•I 387. M. M Dlkydcooklorlde 1*0-220 C
V-ckloco-1-12- (dietkylaalaol etkyll -5-(o-flaoropkeayll -1, J-dlkydco-
T-cfcloro-1-{2-«
ayadtoM, blood alcohol l«nl 2.98
9/1
111 died of ac«te lotoxlcatlca froa
coablnatlon of pkeoobarbltal ud
f laraxepaa
Cata alao available foe soae
aetabollte*.
Beep coaa. cacdloclrcolatocy
collapae. Bkodt, coaplete acafleila.
Sack cue kad 1 oc aote ol tba
follotlag: polyvlaceral coaoaitloo.
cacebral injacr, eocepkallc aad
pglaonacy edaaa, btoaeblal pnaaonla.
hepatic clrchoela.
IDDLtSt CBILDIBI: IOTOPSIES!
IITICOITBISIHS) HtPBOIICS;
IITIOIPIESStn iOEITSi BLOOD PLUBII
tllll; LOIOSt KIDIRS: IITBB: UUBBl
OlDQSi 01D8 TIBIiri: BRIBOtRBS;
SOICIDBt DBOO IBOSB; ITUT
nnBBBCB
Fertata. s.o.
Md*«ehl, L.
Bar 190, a.
Cutagai. F.
1979
-
VO
-------
2B-1,»-Ben»odla«epln-2-one, 7-chloro-1.3-dlhydro-1-Bethyl-S-phenyl-
C16-B13-C1-B2-O
Hi 28*.76. It 125-126 C
TISSUE
33*1
Hood
33*2
Bloo4.
plasea
33«3
Blood,
plasna
33«»
Blood,
•eras
EIMSOBB BOOTS
Xngestlon
Injection
Injection
Injection
lectal
Injection
IIILTTICIL
HRBOD
or
or
TLC
ix /as
oc
oc
oc
BOBBEI
OF CASKS
•"31
•) 1
b) 1
6
11 161
..
0.00«-6«.0 ag/nl
.
a) lot given
b) lot given
c| Bot given
d) Bot given
e) Bot given
f) Bot given
•I 9.5-900.0 nnol/1
b) 9.0-750.0 ng/sl
a) *6«-960 ng/nl
b) 121-300 ng/il
c) 62-18* ng/nl
(Blth nornal
cardiac, hepatic, and renal function.
Iges 2«-60 yr.
DIDOS; DIDO TBBBtPI; DEIBtll; BLOOD
StBOl; k DOLTS: COBBklaTITI
BVIIOITIOBS; HTUOLITES
IEFEBEIICE
Finkle, B.S.
Bccloskey, K.I.
Goodnan, L. S.
1979
Dnndee, J.v.
Gaable, J.l.S.
issaf, n.i.E.
197*
BacLeod, S.I.
Giles, a.G.
Banger t, 8.
Lin. T.T.
Sellers, Z. II.
1979
•agnassen, I.
Oiland, 8.I.B.
llsbirk. (.1.
trnold, E.
1979
N)
O
-------
2B-1.«-Banaodiax«pla-2-ona. 7-chloro-1.3-aihrdro-1-aethrl-i-pk«n7l-
•39-1B-S
C16-B13-C1-I2-0
if 28*.7<. n 125-126 c
(COnifOBD)
rtssat
33*5
Blood.
Mraa
33*6
Udaaf
33*7
Line
33«S
3.1 if •
•XMsmi Mm'
IngaatlOB
lOgeatlon
Injactloa
Ing* at Ion
injection
Ingaatlon
atiLrriciL
HBTHOD
OC
oc
Of
nc
OC/BS
oc
or
nc
OC/RS
GC
lOIBHl
or cuts
It
11
202
25
11*31
*) lot gi»aB
b) lot glren
c| lot glTen
d) lot gltan
0.200-13.0 «g/g
0.180-60.0 09/9
-
a) 2.0-30.0 n«/ll
b) 1.5-70.0 ng/nl
rail
•I 211.00 » oc -
82.2* ng/al
b) 221.25 » or -
111.65 ng/al
o| 85C.10 » or -
251.88 ng/al
d) 7*0.28 » or -
352.82 ng/al
3.57 19/9
«. 23 119/9
a) 10.5 B9/nl
b) 19.1* 09/«1
oiiiiii motaiTioi
•) D»j 7 of 2 19
fe) Oty 1* of 2 19
el D«T 7 of 10 ng 3i/d*r
II D«y 1* of 10 ng 3x/d«T
Ittecta OB piychoaotoc
lnt*r«ctlon nith alcohol tut«d IB
•cit* and aibacit* itadl*«.
laalthy •tadants. 5 faaalas, 13
•ilu, 20-26 re old.
10 ng allghtly incnuad reaction
tlnu.
OIOOS; DIUHM9S; COHPIMTITI
HILOITIOIS; BLOOD SBIDB; BIUBOLXSB;
HOBO LOGIC BlliriSTHIOIS: PIllklD
Inccaasa In dlaiapan-calatad daatka,
1973 - 1976. IB 2 cuu. dlaxapaa
•aa tha aola cauaa of daath.
lacorda of 1239 daath* IB 0.S. and
Canada. In all, dianpaa or Ita
natabollta van praaant In tha
tlisaaa and, IB Boat caaaa, ton than
ana drag »aa found, igaa: laaa than
5-graatar than 65 it. Ugh tcagaancr
of aalcida. othar data avallabl*.
Colaonarr and vlacaral congaitlon
aoat coaaon poatnorta* finding
01053; DIOG IBOSI; CMiDa; OIITBD
MltBS; OIIB; SEOaTITBS; BTPPOTICS;
tStCaOTBOPIC DBOCS; BLOOD; L1TBB;
IIDIBtS; I1COBOUC BETBBiOBS;
TOIBBSIC BIDICIIB
DlaTapan-ralatad daatha, 1973 - 1976.
In 2 caaaa, dlaiapaa «as tha aol*
caaa* ol daath.
lacorda of 1239 daatha in 0.5. and
Canada. In all, dlasvpaa or its
aatabolita »ara praaant in tb>
tiaaaaa and, IB aoat caaaa, tore than
oaa drag "as found, igaa: l«aa than
S-graatac than 65 jt. Blgh fragnancr
of aalcida.
CalaonacT and flacaral congaftlon
loat coaaon poataoctaa finaloq.
DBOGS; 0(06 IBOSB; CklaDa; OHTBD
iflTBS; OT»B; SBOaTIIBS; BTPIOTICS;
tSlCBOTBOPIC DIOGS: BLOOD; LIT IB;
KIDIETS; ULCOBOLIC BBTBB1GBS;
fCIEISIC BEDICIIZ
a) Olaiapaa
t| l-daaaathyldlazapaa (aatatollta)
Oiaxapaa doaaga of 6-«5 ag/dar-
latlaatad frc* graph.
Inpatlanta at Toronto (aataro
Boapltal or Lrndharat Hospital,
Toronto, 19-79 ft eld.
DBOOS; DIHEPKIS; EBTtBOLITBS:
SILITI; CKtDl
IBNIBICB
Pain, B.s.
Linaoila, B.
Saario, I.
Battila. B.J.
1979
Fiakla. B.S.
BcCloakar, K.L
Goodaan, L. 5.
1979
10
PiBkla. B.s.
RcCloakar, K.L.
Goodaan, L.S.
1979
Giles, B.C.
Blllar. B.
flaclaod, S.I.
Sallara. t.x.
1990
-------
2R-1.«-*.«niodi»«plt-2-on«.
60»-75-1
B« 26C.7a, HE 205-206 C
TISSOB
33»«
Blood.
plasaa
3350
Ocin*
BXWSBIt BOOTS
In9«etlon
Tng«*tioB
MURICll
RETROD
•PIC
RUBBER
or CISBS
1
11
RftROB
lot ippllctbl*
38. 6-69.0*
RMI
1.2 •»/!
56.75%
Giimi Tiroiamoi
Initial toilcal09lc *ii*lr*ls.
18-yr-old •>!•. In «t>q* o ce««. had
iD^Mtcd 22.5 t •tbchlOETynol, 1.5 9
oiazcpai. 360 19 flnraxapai, 5*0 19
(banobacbltal. and 600 19
AiplwgardrailM.
GIOGS; OBOC »BDSB: HTPIOIICS;
SCDtttllS; SOICIOBi UV1GB; EtOOD
PUSH*; CtSE BISTOBItSj
iniCORVOLSalTS; TBtlQOItlZBFS
1 cf do«« in «8-hc acin*. PU«u
hale-lie* «nd clunnc* hiqhlr
correlated litn that ol antifycin*.
stadant non-nok«ra. 19»» 2 1-33.
OIltBPkHSi HH.GBSICS-. BISCOISII;
EBD8S: BBTIBOLISB
BBFEBEBCE
Banonitx. 1.
Ibolin, c.
Tour, T.
POMDb«C9, J.
Rogara, (.
Pond, S.
schoanfeld, P.
naaphr«T>, B.
1980
Mlleriann, 6. H.
L«Ttttn-Kell«caann, B.
1979
to
IV)
-------
2B-1.*-Bea«oalB*epla-2-OBe. 7-cU.tco-1.3-dlkydro-5-phe>yl-
1088-11-3
C15-B11-C1-B2-O
•I 270.73
(ISIOI
3351
Blood
3152
BlOOd
3353
Blood,
plBBBB
335*
BlOOd,
Beras
•Hosan IOOTI
IngeitlOB
iBjectlon
Ingestloa
iBgeStlOB
tllLITICIL
unoo
iBBBBOenZyaatlC
oc
or
«LC
QC/BS
OC-BC
BOBBBB
or CUBS
77
. - .. - .
B) 10
b| 10
B| «
b) B
c| 10
BtlSE
Bot given
0.10-13.0 «g/al
B) tot given
b) Bot given
B) 268-433 ng/Bl
b) 1SC-217 ng/Bl
c) 170-286 Bg/Bl
(IBZT
nil
390 Bg/100 Bl
0.99 tg/Bl
B) 273 Bg/Bl
b) 198 ag/Bl
B) 371 Bg/Bl
b) 185 sg/Bl
e) 216 Bg/Bl
PMJB1
GBIEU1 XBTOBBMXOB
toxicology case. Blztare of
bsnzodiaiepins.
BIOOS; BILB; BBIIB; II Till KXDBBTS;
OIKBMBS; (1000; IB1STOBBEB1 SBTBODS
DlBMBBB BBtBbOllt*
BccocdB of 1239 d«Btbi IB 0.9. Bad
CBBBdB. IB Bll, diB««pBB OC it*
BOtBbOlltO MM pCBIBBt IB tBB
tlBVBBB BBd, iB BOBt CBMB, BOC* thBB
on* dcag ••• foasd. Bg««: !«•« thBB
S-gnBtec thBB 65 yc. Blgh fc*gaBBey
Of BBlcld*. OthBC dBtB B*BllBbl«.
FBlBOBBCI BBd *i*C«CBl COBgVBtlOB
BOBt COBBOB DOltBOEtOB fifidlBg
oioGS; DBOO IBOSE; ctiioi; ODTBD
SlifBSt OTIBj SBDtTITBS; BTFMTXCS:
(SKBOTIOPIC DB06SI BLOOD; 1ITEB;
(IDBBTS; BlCOBOLIC BET SHOES;
rOBEBSK HEDICIIB
i) P«tk 1«»«1. 1.8 he after IS Bg
plBB *Bt«C
b) MBk lofBl, 2.B he Bftoc 15 Bg
[lam BagaoiiBB aloiln«B hydcocld*
Oata available for klBBtlc TBclablBB
aid other til* points Bp to <6 he.
Btalthy »olant««rB, 23-70 jr old.
SBlf-CBt*d BBBBBtlCBB Of "ap»C«y",
•thiBklog BlanBd do»n«, and cf
g«BBcalli«d BBdatioa oecaccBd In both
gcoapB bit BacllBr BBd 10 r* ccofoand
ihBB takon *lth «tt«r.
DlOflSl PSTCBOTBOPIC DBOOS: OIUO
TBEBiFT; tlltBPABS; BLOOD PL1SDI;
CCHPHITHE ETILOATIOES;
BISS1CBBSB1TS
•) PvakB, yoBsg controls. p«ak tla««
0.5-2 he
k| PBBkB, oldarly control!. Paak
tiBBB 1-3 hC
c) PaakB. gaBtccctoar patients. Peak
tltBB 0.75-6 he
20-ag clocaiBpat* dipotasslai after
tut.
Btalthj controls (ages 20-26 ye),
eldocly ccntrols (ages 50-75 ye),
Itllroth gaatcBctoay patients, (aqes
36-68 yr) all healthy >2 ye after
sacgecy.
CBOGS; OkSTROIITESTIIIL SISTEB; BLOOD
SHOIl! SOIOBII; DISEtSES; IDCLTS;
ICI; 1BT1BOLISH
EEFEEEICE
SllgktoB, E.I.
1978
FlBkle, B.S.
BcCloBkey, K.L.
OOOdBBB, L. S.
1979
ShBdec. B.I.
OeocgotBS, I.
Gceeablatt. D.J.
Bacaatz, J.S.
lllen, B.D.
1978
Ocks, B.P.
Geeeablatt, D.J.
tllen. B.D.
Harsatx, J.S.
Shadac, B.I.
Bodea, c.
1979
tss
-------
2H-1.«-Ban«odiaMpin-2-on«. Vchloco-1.3-dihrdro-S-ph«nTl-
C 15-81 1-C1-B2-0
N JT0.73
(COITIIOEO)
TISSOV
3355
Llf«C
EXPOSURE ROUTE
Ingest ion
Injection
klkLTTICtl
BETHOD
OC
or
TLC
OC/BS
IOBBBI
OF CtSBS
T
I^IOZ
0.57-28.9 09/9
BBII
5.«S tg/g
GEIEB1L IirORItTIQI
Clmpti ••tabollt*
fccocda of 1239 deaths In 0.!. and
Canada. In all, diaxapai oc lt«
Mtabollt* ««ce pr««ent in tte tissue
and. In ao*t ca«««, aoco than one
dng va* found. &9«a: less than
S-gr«at« than 65 fr. High fcaguncr
of «aicid«. Oth«r data available.
Fvlionntr and »i«c«c«l congestion
acat coanon po«taoct«i finding
tlOOS; D10G tBOSB; CIIHD1; DIITBD
Jims; OTAR; SSDITIVBS; RIPIOIICS;
P3tCHOT«OPIC DRUGS; BLOOD; 1 IT El;
KIDIEIS; HCOBOLIC BEVBB1GBS;
rciBusic lEcicmE
BEFEREPCE
rlnkla, B.s.
BcClaker, K.L.
Coodnan, t. s.
1979
S3
-------
2l-1,a-S«B«odlampiB-2-oa«, T-cBloro-S-25 be.
Data also on 2 caaaa of ocal doa*.
Pitlanta «1.7 » or - IS yc old.
aargacy aa Icmc atdoaaa aad
• itraaitlaa. aplnal aBaathaaia iiith
lldociln* oc aapiracalna, locatapaa
aa a pcaaadlcatioa.
CIIHIOSPII11 PUZC; IDSCII
inmiTS; IIMIIBTICS; BIOOC SBBOB;
SOBOBIT; PIIUID
a) OBConjagatad
b| Coajagatal
Caa ralaa pac caaa. Tlaa aftac 0.03
ag/kg If «clad fcca S.2S ->2S .in.
Cata also OB 2 caaia of ocal doaa.
Patlaata (1.7 » or - 16 yr old.
aacgacy OB levac atdoaan and
aitcaaltlaa. aplaal aaaatbaaia «ltb
lldocalaa or aaplvacalBa, loraxapaa
aa a pcaaadlcatloa.
CIIEBIOSPII11 FLO 1C; HOSCLB
ItLlItlTS; HSSIHBUCS; BLOOC SBBOB;
S010BIT; PIIUID
MPBiBICE
taltoian, I.
Kaato. J.
Salo. B.
1980
laltoaan, L.
Kioto, J.
Salo. n.
1990
-------
3-Beptanona, 6- (dlaethylailac) -*,*-dlpkenyl-
76-99-3
C21-B27-B-O
11 309. IP Bydrochlorid* 235 C (dl fora)
TISSOB
3158
Blood
33M
Blood.
plaaaa
IXP03VIB BOOTS
Inge at ion
• BILTTICIL
IITROD
QC
IOBBBB
or cists
•6
21
UNI
0.02-*. 1 ug/al
_
a) 0-135 ag/al
b) 135-200 ng/al
BEtl
0.62 ag/al
a) Bot applicable
b) Bot applicable
GIIII1L TirORBlTIOl
. _
Caath caaaad by drag coibi nation*
Beeorda of 1239 deaths in 0. s. and
Canada. IB all, diazepaa or ita
aatabolite >ere present in the
tlcsaes and, in aoat caaea, lore than
ana drag «•< foaad. ages: laaa than
t-greater than 65 yr. Rlgh (regaancy
of salclde. Other data available.
Paleonary and visceral congeatlon
tost coaaon poataortea tindirq
DB0GSJ DBOO tBOSB; CHID*; OBITED
Sims; OTIB; ssDitms; atppoTics:
fSICBOTBOPIC DP DOS! BLOOD; UTtB;
IIDBETS; IICOBOLIC BETBR10BS;
FORBBSIC BBDICIBE
at Bange of aeans 0 and 8 daya. Dose
30 ag/day. *-12 patienta par awn.
Final valae, 100 ag/al, day 22
b) Bange of eeana 0 and R daya. Dose
CO ag/day. 10-16 patieata par aean.
Final valae, 170 ng/al, day :*
Dose, 30 ag/day for 10-2* daya, then
60 ag/day for 10-2* days.
Considerable Individual variation.
Patients, coapalslve opiate abas* >*
yr. 22-41 yr of age. ill «*re heavy
aaokars. Detoxified before atody.
20 aaa, 1 «osan.
lehabilltatioa ranking correlated
alth plasaa levels.
CIOOS; DBOG TBBIIPT: BLOOD FliSil;
SIIOBI; PSTCBOTIOPIC DIOOS: CFOO
IBOSE; (DOITS
mrttttct
Flnkle, B.s.
BcCloskey, t.L.
coodaan, t. s.
1979
Rolaatrand, J.
tnggard, 8.
Gonna, l.B.
1978
-------
J.S-rrn«1114lB>AiOB*>, 1.2-4ipk«Brl-*-(2-(pkoBrl*BlflB7l)«tkyl)-
S7-96-S
C 23-120-12-03-3
If MB.B8. II 134-137 c (dl COCB)
TXSSUB
3360
Hood,
plBiBB
3361
Blood.
plan*
nrosnn toon
Iag*«tlOB
XajBctiOB
iBgcBtlon
BMinXClL
mice
oc
IP LC
_
BOBBII
or CISBS
•1 2
b| 6
•1 2
b| 6
el 6
•MSB
•1 6.7-11. B ag/Bl
b) 10.7-30.1 Bg/Bl
B) 112.1-0.8 Bg/Bl
b) lot glfra
c) lot giY»
'
•III
•t 8.7 «9/Bl
b) lot gt*«B
•) lot BpplicBbl*
b) 18.9 og/Bl
e| 35.8 ag/Bl
nuiiL inroiMTXoi
• ) MBk B(t« UltlBl 200-19 dOM
b) ItZlBBB ItMdT «t«t« l«f«b Bt 10
d«T* follo»lBg 200 Bg t.l.d.
fttlnt* udirgoing k«Bodl*li«i« (oc
ckconlc C«BB! (Bllar*.
PC*nBtlo> Of plBtBlVt COBBBBptlOB
• Od pCOtCCtiOD BgBlBBt d*CE«HDt Of
• BtltkCOBblD HI AUElBg h«BOdlalT*i».
CM8SI BIOOD PLtSBI; DIOG TBOtn
•
B) 0-28 bC BBBBB BftBC IV bol» Of
6.7 Bg/kg. TEi«XpOBBBtlBl dBCliBB
t| R«BB p«Bk Bft« 200 Bg, oral.
t«Bk Bt 1.6 hC
C) IBBB p«Bk BftBC 600 Bg, OIBl.
(BBk Bt 1.6 kC
OthBC dBt* BTBilBbU.
B«ltky BBlBB, Bg** 22-18 jt.
DIOGS; BtOOD PlaSlk; MUCH; 1 DOITS;
CCHIIITXVC ITllOITIOIS
IBFBBBICI
BBCB, B.B.
C*T*II*C«. a.i.
iBkBB. 6.
1980
LBCBillOB. J.B.
SOBppBCt, C.
SckOBllBE. J-P.
BBBbBCt, 6.
BBBBlBB, P.
1979
to
•vl
-------
3B-1,*-Beniodlaxeplne, 7-chlcro-2-(aethylaalno|-S-phenyl-, *-oiida (8 CI)
3B-1,«-B«nio.H«iepin-2-aBlna, 7-chloro-l-eetkyl-S-phenyl-, »-oxide (9 CI)
58*25-3
C1S-HH-C1-I3-O
II 299.11, BE 236-236.5 C
TISSUE
3362
•load
3363
BlOOd,
plassa
336*
Blood,
plant
EIPOSOiB IOOTE
Ingest ion
Inject loa
Injection
allLTTICtL
RETROD
Plnoroeetry
Vlaoroaetry
I01BE1
or OSES
18
.. r ,
10
2S
BlIGE
0.8-6.0 »g/al
>) 1.2«-2.50 09/1!
b) 1.00-2.50 »g/al
e) 0.98-2.09 ug/sl
d) 0.2T-1.35 og/al
•1) 0.3B-O.T* ag/Bl
f) 0.1 «-1.35 ag/al
g) 0.3*-0.6> ag/al
M 0.15-0.63 ng/sl
a) 2.9-0.51 qg/al
b) 2. 7- 0.1 3 ag/sl
e) 0.38-0.23 ug/sl
d) 0.68-0.20 ng/Bl
RCll
2.7 ag/al
a) 1.88 ag/al
b) 1.87 ag/al
c) 1.38 ag/sl
d) 0.71 «g/sl
•) 0.65 ug/al
tl 0.91 ng/Bl
4) 0.53 «g/sl
h) 0.52 ag/il
•) lot applicable
b) lot applicable
c) lot applicable
d) lot applicable
GEIttll IirolRtTIOl
Death caaaed by drug coibloatlons
Pecocds of 123<> deaths In D. !. and
Canada. In all, dlatepaa oc lt«
letabollt* «en pceaent In tbe
tlacqes and, in Moat cases, lore than
one drag Has tound. tges: Itss than
5-greater than 65 yc. High frequency
o( snlclde. Other data available.
Polsonacr and visceral congestion
sost cosson postsortes finding
D10GS; DIOG kBOSE; CaltOli OUTEO
StlTSS; OTtB; SEDlTIfBS; BTflOTtCS:
PSTCBOIIOPIC DBUGS; BLOOD; Lit 81;
IIOIETS; I1COBOLIC BEfSSlGES;
fOBEISIC DEDtCIlE
a) 1 oral dose
b) 2 oral dosea, second dose 1 vk
later
c) 1 Tl dose
d) 2 IB doses, second dose 1 u\ later
e| 1 oral doae, as Mtabollte,
l-desiethylcklordlazepoiide
f) 2 oral doses, second dose 1 «k
later, as eetabollte.
l-deasethrlchlordlaxepoxide
g) 1 m dose, as aetabolite.
l-de«aethrlchlordlazepoiide
h) 2 18 doses, second dose 1 «k
later, as aetabolite.
1-desMthrlchlordlazepoxlde
2 groips, 5 cases oral doses and 5
cases ID doses.
Psychiatric patients aged 23-«5 jt
diagnosed aa alcoholics or aa having
had alcohol withdrawal.
CIOSS; BLOOD PlaSHa; JLCOBOLIC
IITniGES: SEDtTITES; 8ET1BOUTES;
COBPJUTHE ETkLOanOIS; 1011
a) Chlordiaxepoxide, 11 cirrhotics.
Bange of aeans, 0-«8 hr, continaoas
decline
t) Chlordiaiepoxlde, 1» noreala.
lange of Mans, 0-«8 hr, contlnooas
decline
c) DeaaethTlchlordiaxepoilde, 11
cirrhotics. Bange of Mans. 17 and
•8 hr. 0.1 ag/nl at <1 hr
d) Deaeethylchlordiaiepoxide, in
noraals. Bang* of leans, 9 and *8
hr, 0.21 ag/nl at <1 hr
•alaes after 50 ng of the
hyilrochlorlde IT over 10 aia.
Iitlaated fros graphs.
lealthr sales, aean age 25. a yr, and
sate alcoholics elth cirrhosis, aean
age IT. 8 *r. all abstaining froa
alcohol and drags >2 >k.
OIOGS; CIliMSIS; BEIJBOIIS8J BLOOD
FllSai; LITII DISEtSES: 1DOL1S;
CCBPllHITB tTILOlTIOIS;
HllQDILItEIS
BEFEBrllCB
Pinkie, B.S.
BcCloskey, K.I.
Goodaan, L. S.
1979
Perry, ?••>•
Hiding, D.c.
rovler, B.C.
Repler, C.D.
capato, J.r.
1»78
Sellers, s.H.
Greenblatt, D.J.
Clles, B.C.
laranjo, c.l.
Kaplan, B.
Bacleod, s.a.
1979
K)
00
(IIET HOB)
-------
3a-1.«-MBiodias«plM,
7-chXoro-2-|a»thTX«aiao)-5-ph«ajX-. «-o*ld« (• CIJ
-»iM. 7-ckloro-a-aithyX-5-p»iByX-, «-o«i«» (9 CI»
SI- IS- 3
C16-BH-C1-I3-0
• I 299.75. IF 236-236.5 C
(COITIIOBD)
TISSOB
3365
BXood.
plaau
3366
Saliva
IIMSOBB BOOTB
iBjactloa
iBjlCtlOn
XagvotioD
iBurticaL
BBTBOD
lit
Hi
IOIBBB
or cuss
-
a) 1
b) 1
c| 1
at 1
bj 1
c) 1
BMO.B
a) 1.65-0.7 ug/al
b) 3.5-0.07 og/al
c) 1.8-0.09* ag/ll
a) 0.056-0.02 og/al
b) 0.07-0.0017 ag/iX
c) 0.0*2-0.002 ag/iX
mi
a) lot glT»a
b) lot giTaa
c) lot glf*D
a) lot glna
b) lot giTM
c| lot git«B
8IICIIL IBPOBIITXOI
- -
a) 10-19 oeaX dom 3x/day. « days, 30
aln-30 he aft«e Xaat doa*
b) 35 ag IT. 30 iln-70 he a(t«c
alagX* dom
c) SO ag IT. 30-70 he aft«c tiagX*
dCM
Eatiaatai Icoi geaph«.
DI06S; BLOOD PL1SBI; SU.IT1;
CCRPlBaTXTB ITtLOllIOIS: BBaJUIBniT
BtllODS
a| 10-ag oeaX doa* 3c/day a dayi, 30
•la-30 he aCtac Xaat do««
b) 35 ag IT. 30 aln-70 he aCtec
aiogXa doa«
c) SO ag TT, 30 aXa-70 he after
*ingX* doaa
latlaatcd (co* gca(h.
DIOQS; BLOOD PttSRI: SILXTl;
CCRPiltTXTB ITilOtTIOIS; IBtSOBBRBIT
IITIODS
IBTBBBICB
Lornk. B.
DiroB, I.
1980
Look, B.
DlZOB, B.
I960
-------
«(3")-Qaina»oUoone, 2-aethyl-3-o-tolyl- (S CI)
• <3*.)-0.alna«ollDOBe. 2-Mthyl-3-(2-eethylphenyl|- (9 CI)
72—*%-6
c«-«i»-i2-o
HI 250.29, SI 120 C. also given 4> 1U-116 C
TISSUE
1367
Blow!
3368
Blood.
plain
EXPOSOIB HOOTB
Ingeitloa
ItaLTTXCal
RETROD
GC
-
1
01
29
al
b|
c)
4)
•1
f)
9)
IORBEI
or cuss
29
•t
b|
c)
4)
•1
f)
9)
URGE
0.1-23.0 ag/el
a) 2.31-0.39 ag/al
b) 2.6«-0.30 09/al
c) 2.59-0.2* og/el
d) 2.57-0.36 ug/el
•I 1.99-0.13 ag/al
f| 2.19-0.31 ag/al
9) 1.93-0.16 ag/al
mi
5.5 ag/al
al lot applicable
b) lot applicable
c) lot applicable
d| lot applicable
a) lot applicable
f) lot applicable
g) lot applicable
GEIEIaL IIFOBIUTIOH
Ciath caused by drag eoablnatlon*
Record* of 1239 death* In a.i. and
Canada. In all, dlaxepaa or its
tlaeaea tnd, in aoat c«s««, lore than
one drag ««» found. >ge<: lue than
5-greater than 65 yc. High fregaency
of salclde. Other data aTailable.
(alaonary and rleeecal congeatlon
ioat coaaon poctaortea finding
DIOGS; DSOG 1BOSE; CkltOa; OIITID
SltTES; DTtB; SCDtTITESj BTPIOTICS;
PStCROTBOPIC DPOCS; BLOOD: L1TEB:
RIDIETS; tLCOHOLIC BEVERAGES;
rOREISIC IIEDICIIE
a) Peak level to level at 3* he
b) Peak level to level at 3« hr
c) Peak level to level at 3« hr
d) Peak level to level at 3« hr
e) Peak level to level at 3« hr
(I Peak level to level at 3« hr
g) Peak level to level at 3a hr
Individual* received aiagle
therapeatic do*e* of 300 ag.
Healthy aale volunteers
tlOOD; BLOOD PtlSBl; DBUCSi CBOG
TIIBIBT
eerRBEicE
Pinkie, B.S.
Hccloskey, K.L.
Goodaan, L. S.
1919
Clifford, J.B.
Cookion, J. R.
Rlckhaa. P.E.
197a
OJ
O
-------
•~rip«rldlBol, l,3-dlB«tkyl-*-ph*Byl-. propioe«t« (Mtor) |8 CI|
l-flp*riaiBol, 1,3-dlB«tkyl-»-pfc«*yl-, pcopMoct* (Mt«r), el>- (9 CX)
1T-20-3
B1C-I23-I-02
II 2C1.35
TISSUE
33S9
Blood,
plan*
Exrosois toon
inj*ctiom
mimciL
BBTBOD
ac
IOBBE1
or cisss
c
Btiet
1.12-0.068 >9/>l
_
nn
...
lot ippllctbl*
elllllL IIFOIUTXOI
0 *nd 300 •!> «(t«t 0.0*S« ig/kg IT
IB 2 Bin. Bliiponintld d«cUn«.
ICB-SBOkon ilthoBt neont kcpitltls
cr Hpanc* to •«dlc»tion«, iboat 22
yr old.
DBOSS; HBCOTICSJ BIOOO PLtSUi
i COLTS: cuifoiiii: COBPIIUITI
H41B1T10BS
IEPE1BICS
FOOg, O.L.
Uling, J.B.
EinU, J.I.
Bicticcl, I.
1980
-------
u-T1>l«-l-a»ablcTclo(3.2.0)Lept«ne-2-carboiyHc acid, 3,3-dlM>tbrl-6-(« ((3-(«thylso IfonyU -2-oio-1-laldaxolldlnTl> cacbonyl)aiino)phe orlacetrl) aaino)-1-0*0-,
(2S-(2alptia,Salpb*.6beta(S*)))-
5U81-6S-3
C21-B25-R5-08-S2
HI 539.«3
tissue
3370
Blood.
serai
EXPOSURE IOOTI
Injection
IEU.TTICAL
HETROO
Hlccoblologlcal
IOHBER
or cists
8
BUGS
a) 103-265 ug/«l
b) 51-9.3 99/11
BBll
a) 153 ug/«l
b) lot appllcabl*
«BIIBtl IirOBIHTIOH
a) Peaks
t) 30 and 2«0 «in, >eana
kftec 1.0 g IT orer S lin at
beginning of 5-hr dialysis.
•dnlts, ages 30-74 yr, undergoing
cbconlc Intecelttent heiodialysls.
CRDGS; HTI8IOTICS; REV YORK; KIDRET
CISMSES; BfBODULTSJS; BLOOC SEPOH;
lOOITS; CORFlRtTITE EVIL01TICRS
--
RErERE'CE
ftancke, E.
Benta, s.
leu, H.C.
Appel, c.B.
1979
ON
-------
«-Tkla-1-asablcTelo(3.2.0)keptBB»-2-cerbo«Tllc cola. 3,3-4lMtkyl-i-oEo-6- (2-pkenoxr'
e-Thie-1-a»ablcyclo(3. 2.0| k«FtBBO-2-csrbo*Tlie sold. 3 ,3-dt«etayl-7-oio-6- ((pkenoxyai
132-98-9
CH-I18-I2-OS-S.I
•I 38*.52
cetaeldol-. sonopotaules salt (8 CI)
etyDaslno)-. soeopotassias Hit. J2S- (2alpha.Salpha,Sbeta) J- (9 CI)
nssai
3371
Blood,
seres
3372
S«I1»«
3373
Tear*
BXIOStttt BOOTH
Xagestlon
IngeStion
IngOStiOB
IIILTTICU.
mioD
Blccoblologicsl
Bicrobiologlcal
Ricroblologlcal
IDIBBI
or C»SBS
•1 16
b) 1*
t| IS
b) 1*
15
urn
•1 2.1-0 ug/sl
b) 1.1-0.02 Bg/Bl
B) Bat gl»«n
b) lot 9l»«n
•) lot gl*«n
b) lot glT«n
mi
i) lot ji»«B
b) lot »l»»n
•) 0.36 aj/«l
b) 0.8* 09/«1
a) 0.5 ag/il
b) 0.3 ag/al
SBIIBlt XBTOBB1TIOB
•) Fut«d 2 kr bcfon «nd after torn*
b) t«k«B vltk 118 il of Bilk or
(orial*
lango of •••BS 0.5-6 kc tft«E 8 ig/kg
169 ctidl** ««r. 4on« vltk 106
lofanti and children.
Iiftnta and childrci with ill!
•icocitai«o«a infvctlou, otltta
a
-------
a-TMa-l-aiabicrclo(3.2.0|hBptana-2-carboxrllc tcld, 3.3-dlBethyl-7-o*o-6- (2-phanrlaoataaldol -, aonosodlaa Bait {6 Ct) (Tll(
«-Thla-1-aiablcrclo(3. 2.0)h«ptaBa-2-cacboirllc •eld. 3,3-dl»athyl-7-oxo-6- ((phanrlacatrl) aBlaol - (2S-(2alpha,5»lph« ,6b«t«l|-, aonoiodloa Bait (9 CI)
C16-R16-l2-0«-S.la
HI 356.38
TISSOB
337*
Blood.
BOCUB
3375
sail**
3176
TBWCB
BIFOSOIt BOOTB
Ingeatlon
Ingaitlon
Ing*Btlon
UlLTTICaL
BETHOD
Ucroblologlcal
Blcroblologlcal
Ucroblologlcal
BOHBSB
OF CaSBS
II 9
b| 1*
23
5
IIIGB
a) 0.98-0.02 ug/al
b) 0.61-0.02 ng/al
lot given
lot gl>en
a)
b)
a
0.
ran
lot gtna
lot ql»»n
0.09 nj/al
1BIEHI TIFOIBITIOR
a) FaatBd 2 he before and after dos*
t| Takan *lth 118 al of Bilk or
tocaala
Vala«B ac« cang* of i««n« 0. 5-6 he
attar a Bg/kg
1(9 atndlaa »r* don* «ith 1C6
Infanta and chlldt«n.
Infanta and chlldraa vith alld
agcocatan«oia In factions, otitla
B«dla. and phacyngitls, agvs 2-«6
aontha.
IITIBIOTICS; CaitOBBI; FOODS; B1OOD
SCIOI; SH.HI: TBH3; TBltSi IIFIITS;
CC9PIP1TITE ETtLOtTIOIS
gaan peak aftar B Bg/kg «aa 0.13
ag/Bl
169 *tadl<« «ara dona Kith 106
ioCantB and childran.
Infanta and children vith alld
aacocotanaoaa Intactlona, otitla
aad la, and phatyngltla. agaa 2-46
aontha.
IITIBIOTICS: CHIIDIII; FOODS; BLOOD
SIIDB; SUITa: THIS; TBUS: IIFUTS;
COIPHaTIfE ETaLOaTTOIS
Man puk aftac 8 ag/kg
169 atudlal >ar« dona alth 106
Infanta and chlldcan.
Infanta and chlldcao *ith alld
aococatancona lnf«ctlona, otltl*
aadla, and phacrngltla, agu 2-«6
aonthB.
IITIBIOTICS; CIIIIDIBI: FOODS; BUMD
siion: stiifi: TEiis; TBIIS; IIFIITS;
CCR»allTITI ITtlOaTIOIS
BcCcackan, J.h.
clnsbacg, c.n.
ClahMn, J.C.
Thoaas, B.L.
197B
BcCcackan. G.B.
Oiaabacg, C.B.
Clahaan, J.c.
Thoaai, H.L.
1978
co
BcCrackan, G.B.
GlubBcg, C.B.
Clahaan. J.c.
Thoaaa, B.I.
1978
-------
. 6-(|««l»opfc«Brl«c»tTll««lBO|-3.3-«l««thTl-T-oio-, 1.3-41ky«co- 3-o«o-1-i«ob««of«c«»Tl «»t
(23- (2tlpht.Salpht.6tMt* (3*)
CS«-«23-»3-06-S
•I «*1.52
man
33TT
Oci««
BIPOSOU Mm
Inaction
iUMTXCU
nnoD
Uecoblologloal
gc/is
-
ivnn
or CUB
1
•MOB
•) lot gl*M
b| lot firm
e) lot glT«n
•»•
•1 93. J*
b) 95.0*
e) *T.SS
__
oiiiui inoiHiTioi
•I 0-2* be
b) 0-»8 kc
e} 0-H« hr
r«ce«Bt of da** (7 if/kg) *icr«t*4
b»*4 OB ctAioactl** label la tk«
•«t«bolltm.
lOMtl «dllt« > »5 yc old.
Dioes; iiTiaxmxcsi OSIIB:
•RiaoLins
izriuio
j«(f«y. D.J.
Jom>, E.B.
U.JI.T. P.r.
Ul
-------
*-Thla-1-aiablcyclo(3.2.0|haptane-2-carboxylic acid, 6-((carboxy-3-thienylacetyllaalnol-3,3-dliethyl-7-oxo-. <2S-(2 «lfha,5alpha,6beta (S»)| I-
3»787-01-»
C15-H16-I2-06-S2
If 3Ba.«S
TissoH
3378
Blood.
•eras
3379
Orine
BIPOSOM HOOT!
Injection
Injection
• niniciL
RITIOD
IORBN
OP CiSES
17
17
™Ki
a) lot given
b) lot given
c) lot 9l»an
a) lot given
b) lot given
a) 20 tg/1
b) 56 ag/1
c) »20 ag/l
700 »g/l
3200 19/1
GEIIB1L IirOBHATIOH
a) 6 nn, doa* 3 g/daf Cor 1« days
t) 1 aaa, dole 3 g/day toe 1C days
e) 1 aan, dose 18 g/day (or 12 days
Ittcaga p«ak le»«l«
Other iDdlTldaal le»els for various
dose rates glten.
18-86 yr old patients vith
CSBOOOHOIts IEROOIIOS* infections.
One patient shoved evidence cf
toiicity: falling heioglobic and
platelet levels, in vltco platelet
disturbance, krpokaleeia and fever.
Svaptoas disappeared «lth cessation
of therapy.
DBU1S; DB06 THBBIPT; BLOOD SIBOB:
OBTIB; alTIBIOTICS; kOSTRALXl
a) 6 sen. dose 3 g/dav for 14 days
b) 1 san. dose 3 g/dav for 1C days
Average levels for randoely leasured
staples
other data available.
18-86 yr old patients vith
PSBODOBOIaS aBROGIIOSft infections.
One patient shoved evidence cf
toiicity: falling hasoglobin and
platelet levels. In vitro platelet
disturbance, hypokalesia and fever.
Sysftass disappeared vith cessation
of therapy.
DBOGS; 0100 THEBIPT; BLOOD SIROB:
OBIIti AITIBIOTICS; HOSTB1LII
BEFEBEHCE
Frociv, t.
Pearaan. J.
1979
Prociv. t.
Pearaan, J.
1979
ON
-------
a-Thla-1-a«ablaycla|3.2.0)hept*ae-2-earboxylio acid, 6-(2-aaino-2- »o.t.«i4o»-3.3-41«.ihTl.-7-o*o-, o- »e ct)
e-T»ia-1-a*abieyclo<3.2.0)nepta»e-2-car»0«yllc ecld. 6-((aalno(e-hydroxyphanyl)acetyl) ••lno)-3,3-dleethyl-7-o*o, (2 S- (2alpha.5alpha,tbeta(S*| | )
24787-78-0
CI)
•t 3CS.I1. HP 19» C (beta-lephtbaleneMltonat* trikydrate)
TISSUE
3180
Blood.
•ere*
3381
aciiw
. ,
mosnc loon
I*g*atio*
Ingeetloa
1ULRXC1L
BITBOD
Bicroblologlcal
'
_
Bicroblologlcal
mini
OF C1SBS
•I 10
b) 10
10
B1NB
.
•1 6.C-0.5 m/»l
b) 8.6-1.1 tg/ml
lot glY«B
Bill
«) lot applicable
b| lot tpplleablo
40% of doat
a) Bang* of Mana 1 aad 6 ht after
12.5 as/kg. Initial valrn. 3.6 ag/al
at 30 ala
b) Baooa of nana 2 and 6 he after 25
agAg- Initial »alu«. 3.5 ag/al at 30
ala
largo variation aaoag Indlfltaal*.
Bbntroal children'i Boapltal patlonta
•Itk Infoctlon* for «blch aaflcillln
or aaodellllo »«« prescribed.
501 aacceaa cat* In treating urinary
infectlona. Sid* effect*: tiia
diarrhea and toaltlng.
DIOOS; DBOG TBBBkPT; lITIBIORCSj
CIHDil CBItDBBB; HFBCTIOI; OBXIB;
BtOOD SII08; COBPHITITI Bf4IOKIOIS
6-hr acinea
lontreal Children'a Boapital patlenta
•ith Infection* for ihlch aaficillin
oc aaodcillin "«« preacribed.
SOf aacceaa rate in treating urinary
infection*. Side effect*: aid
diarrhea and *o*lting.
DIDOS] DRUG TBEBiPT; UTIBIOIICS;
CIIUDl; CBILDBEl; HFgCTIOl; DIIIB;
B100D SIIOH; COBP1BMITB BfttOlTIOIS
Barka. B.I.
To**, k.D.
1978
Bark*, B.I.
To**. i.D.
1978
U>
-------
•-tkla-1-a«abicrclo<3. 2.0)keptane-2-carboiTllc •oil.
•-lkU-1-aiallCTClo(3.2.01kertBne-2-CBCboiTUc
C16-B1«-l3-oa-S
II 3«9.»2
6-(2-ulno-2-phenrlacetasldo|-3.3-diaethrl-7-o(O, D-(-|- (8 CI)
• -«BBlnophenrlacetyl)aslno|-3. 3-dlsathH-7-o«o-. (2S-(2alpha, Salpha.6beta|S*M 1- (9
TISSUE
3382
Blood,
seen*
3383
Blood.
serui
338*
Saliva
3385
Tear*
i
BIPOSORE ROOTS
Ingestlon
Ingest lOB
Ingostlon
IngeSt ion
iniRXCal
RETROD
llceoblologlcal
Uceoblologlcal
UcroblologtCBl
UecoblologlCBl
IOIBEI
or ctsss
•1 «
b) 3
Bl 15
b) 1»
Bl IS
b) 1«
Bl IS
b) 1«
i
HIM
B| 3.9-0.8 ag/Bl
b) 7.8-0.3 ag/Bl
B) 3.1-0.* ag/Bl
b) 2. 7-0.8 ag/Bl
B| 2.5-0.02 ag/Bl
bl 0.7-0.18 ag/Bl
B| lot given
b) lot give*
tmmrr
BBII
a| lot applicable
b| lot applicable
a) lot gives
b) lot given
a) lot gives
b| lot glTOB
B| 0.83 ag/Bl
b) 2.2 ag/il
r*a»i ' '
OEBCIIL IRFOIimOl
a) Range of nan* 2 and 6 he after
12.5 Bg/kg. Initial vala*, 2.3 ag/Bl
it W alB
fcl Rang* of aeanc 1 and 6 be »ft«c 25
Bg/kg. Initial «alo«, 3.8 «g/«l at 30
Bin
LBtgo faclatlon aaong Individual*.
gontcaal children1a Boapltal patients
•1th Infection* foe «hlch aa(lclllln
or aBOilclllln «a* preecrlbed.
5 of 7 «ece freed of urinary tract
infection*, side effect*: illd
diarrhea and TOBltlng.
DIOOS; 0100 TRERirT; IITIBIOHCS:
CIIIDa; CRILDIEI; IIPECTIOI; OlIIB;
HOOD ssioa; coiptiatiTi Emomois
i) raited 2 kc before and after doae,
•ean peak C.« ag/Bl at 1 he
b) Taken with 118 B! of Bilk or
foraula. Bean peak 6.1 ag/Bl at 2 be
Range of aaan* 0.5-6 he aftei 25
Bg/kg
1«9 BtBdlu «ece done with 106
Infant* and children.
Infant* and children ilth Blld
aacocataneoi* Infection*, otltl*
•edla, and pharrngitl*, ages 2-*6
•onth*.
IITIBIOTICS; OIIL01BI: FOODS; BLOOD
SIBOB: Sltlfas TBIRS; TBI1S; IIFtlTS;
COBFaRlTIfZ CTaLOaTXOIS
•) ra*ted 2 he before and after doae.
Bean peak 0.51 ag/Bl
hi Taken tilth 118 Bl of Bilk or
toraala. Bean peak 1.85 ig/il
falite* ace rang* of aean* 0.5-6 he
169 Bt*dl*B nere done «ltk 106
iBfBBti and children.
Infant* and children «lth Blld
BKocataneoiB Infections, otltl*
•adia, and pnarrnglti*. ages 2-*6
aonth*.
IITIBIOTICS; CIIIDIEI; FOODS; BLOOD
SIBQB; Sallft; TMIS; T8I13; IirtlTS:
CCHPalaTXTI [tatOITIOiS
a) lean peak, fasted 2 kc before and
attar dose
b| Seaa peak taken iltk 118 al allk
OE fOCBBlB
1C9 atadlee Mce done with ICi
Infants and children.
Infant* aad children ulth Blld
sicocataBsoia infection*, otitls
aedla, and phacrngltls, ages 2-*6
BOBtkS.
IITIBIOTICS; CBILDIIli FOODSi BLOOD
JMOIl Sltlfl; TElBSt TBIIS; IIFIITS;
COP1IITITE ETItOtTIOIS
BEFEREKCE
Kaeks, n.i.
rose, t.D.
1978
Rcccacken, G.H.
Clnsbacg, C.B.
Clahaen. J.c.
Tbosas, R.L.
1978
U)
00
Rcccacken, O.B.
Qlnsbacg, C.8.
clahsen, J.c.
Tkosas, H.L.
1978
BcCeackan, 6.R.
Qlnsbacg, C.I.
ClBkSSB, J.C.
Tbonas, I.I.
1978
-------
l>-t-*Mbicrclo(J.2.0| k*pt«M-2-carboxrllc «cld,
•-*hla-1-aubicrclo(3.2.0|k«ptM*-2-c»boxrllc •eld,
61-S3-*
CW-IH-I3-0«-S
•I 3«*.«2
8-(2-Mioo-2-ph«Brl«c«tMi.do»-3.3-dl»«tkYl-T-OMO. 0- (-| - (8 CII
6-((«»lnopb«BTl«c«tTl»««iBOl-3,3-aiMtkyl-7-OIO-. (2S-(2»lph», 5«lp»«.6b«t«(S«) ) ) -
(CORIIVID)
CI)
TXSSOB "
3386
OtiM
nnsan MOTE
xnfMtlaa
1ULTTICIL
•RHOD
Uocoblaloqlal
imBM
OP ClSBS
10
UMI
lot jinn
mi
30% of 4o«»
OBIIIII. IITOBB1TIOI
6-hc »!•••.
8ontr»l CkiUccB'* Ba>ptt«l p*U*nt«
•1th lottctloai for iklch ••fielllla
or uotlcilllB •«« pCMcrlbcd.
5 of 7 v«r« fn«d of arlB«ET tnct
iiCcctiom. Sid* •fhcti: illd
dlmk** ««d Toiittnj.
Bioosj DIOO tnikPt; inxBioncs;
CIIIDi; CIIIOIEI; IIFBCTIOI] ami;
BIOOD SBBDB) COSP1I»TI»B BTHOlTIOiS
nrsiBBCB
Btckl, B.I.
fo**, ».D.
1978
VO
-------
t-Thla-1-atablcyclo(3.2.0)heptane-2-carboxyllc acid, 6-|2-athoir-1-naphthaaldo)-3.3-dleeth]rl-''-o>o- (6 CI|
«-Tkla-1-aubicyclo(3.2.0)hepatana-2-carbosyUc tctd. 6-(((2-etho*y-1-naphth«l.enrl| orbonyl) aalno)-3,3-dlaethyl-'-o«o-, (2S-(2alpha,5alpha,Sbeta)|- (9 CI)
1*7-5 2-»
CJ1-I22-i7-05-S
ni «u.S1
TISSUE
3387
Blood.
••CM
EXPO SUM B00TB
Injectloa
IIILTTICIL
RETROD
Uccoblologlctl
IORBBB
OF CISBS
2*
R1IGB
»8. 1-1.8 og/il
REtl
lot applicable
GtlKIl tirotXATIOII
Bang* of Hani 0.5 and • he ift«r
(tact oC 15-iln IT at 37. 5 is/kg.
Children, »gtm 1-163 «o, »ltb
•taphTlococcal Infection*, Dal la*,
TI.
Palebltli at Infos Ion site la one.
neqtcopenla In t«o, and •oalnophllla
In « of 30 patlant*.
D106 lasaiPi: IITIBIOIICS;
1IIIS; CHXIDBEI; BLOOD SEBDB;
iirtcrioi
PEPEBEHC!
reldean, u.E.
•elmon, J.O.
Stanberry, L.P.
1978
-------
•-Thl.-f-.z.blcTclo(3.2.0)k«Ft»*-2-carboirllc acid, 8-J3- (2,6-aichloropk«nyl) -5-««tb7l-«-lioi«xol«c»cboi««ido| -3,3-au«tkyl-7-o»o- (8 CI)
J-Ibi«-1-«i«bleTcloj3.J.O|fc«|*M«-2-e«rbo«rltc acid. 6-< ((»-<2.6-dicliloropl,.nyl.| -S-a«thyl-»-l.oxa«olyl| c.rbonyl) aei«o)-3.3-4ia«tfcyl- 7-ozo-. (2S-(2alpha.Salpha.6b«taM- (9 Cl)
31M-76-S
Cl»-«f»-ClJ-I3-OS-S
1C «70.33. It 5Odin »lt •ODOkrdcat* 222-225 C (d«COIp)
TXSSOB
3388
Blood.
MCOI
-
BXIOSOBB BDOTB
Ing««tloa
lIHTTIcat
BBTBOD
Uccobiological
BDBBBB
Of CUBS
18
-
UBOB
a) «-«0 ug/al
b) 6.5-20 ng/kl
rait
a) 25 ag/fel
b) 12.5 ag/al
SBBBBIL ZBrOBBHIOB
_
•1 aftu 1 he
b| aCtoc 3 he
Still d«t*ctabl« at 5 he
18 Chi Id can. agu 17 ao-16 jt, ulth
•cat* ostaoaycliti*.
1ITIBIOTICS; DBOBS: DBVQ THBUPT;
CBIlDBBBt BOMS; IBFBCnOB;
CILIF01II1; B100D SKBOB
RBFBUICB
Bcycoo. 1.3.
Connor, J.O.
L«cl«cc. B.
Giaiaona, S.T.
1979
-------
•.I'-Blpvrldlnlas. l.l'-dleethTl-
4685-11-7
C12-BU-I2
II 1(6. IP 300 C (dacoap)
TISSOI
33(1
Blood
3390
Blood.
plassa
3391
Blood.
•eCM
3392
Blood.
MCM
3393
BC«U
339*
lout
EXPO SORE SOOTH
Ingestlon
Ingest ion
Inanition
AULTTICU.
HETHOO
III
__ .
GC
in
coioriietrv
lURBEl
OP C1SE5
71
•) lot applicable
b) lot applicable
c) lot appllcabla
110-0.01 19/1
a) lot applicable
b) lot applicable
lot applicable
lot applicable
lot applicable
Mil
a| 86 ug/l
b) 25 iaA
c) 1 og/1
lot given
a) 0.6 pp«
b) 0.25 ppi
l.a pp.
0.089 ppi
0.013 ppi
Oirr riot)
GEIIIU IIIORUTIOI
a) 7 hr
b| 30 hr
c| 120 hr
SO al 'leedol' (S» paraquat) Ingested
hj 32-yr-old patient
Values estimated fcoa graph.
PISTICIDES; BLOOD; ONITED KIIGDON
< oc * 35 he after Ingeitlon of
unspecified aioanti. Peak levels < 2
hr. Bleiponentlal decay, first phase
coaplete at 15 hr.
2 children. 15 adalts. Ingested
weedkillers containing paraquat.
Sirtifed if levels «ere belo« 2, 0.6,
0.3. 0.16. 0.1 so/1 at «. 6. 10, 16,
2* hr after ingest ion.
Jaundice, renal failure, cyanosis,
radiological chaagas. breath lessness
PISTICIOES; OIITED KIIOD01; tLOOD
V1ISR1
a) 12 hr after ing«atlon of 60-80 si
Grasoione-S (200 g paragaat/1)
t) 23 hr after ingestlon, after
•esodialvsis and hesoperfusicn
la paragaat detectable «1.5 tr after
IngeatloB. Death occurred 71 hr
after Ingestlon. lalues estisated
fcoa graph, tdditional data
available.
23 vr old
Suicide
lotopsf shoved considerable aaoimta
caragiat in the organs.
PISTICIOES; BLOOD SBBOB; SOTCIDE;
ctiaaiT
•olsonlag fatality
EISTICIDES; IISEIIC; kLIILOItS:
caiBoi xioicanc CORPOOIDSI BOODI
IXflli KIOIIIS; Bill; 01X11; LOIGS:
BllW; SPLBBI; Blill; BLOOD iBIOH;
TCIIISSIEt CtSE BISTOIIBS
roleonlng fatality
tlSTICIDES; IISBKCi ILKUOICS)
CIIBOI IIOIG1IIC COIPOOIDSl H.OOD!
HTBlj KIDIEISj Bill; OBIIBi LOIOSl
BIUT; SPLIEI; Blkll; BLOOD IE BOB;
1CIIESSEE
ralioniag fatality
(I3TICIDES; USIIICi ILULOIESi
CIIBOI noiainc coarooiDS; ELOOD;
IXfSlj KIDIII3; Bill; OIXlEi LOWS;
lltltT; SPLIIIi BHIll BLOOD SBIOB;
TIIIISSEE
PEPEIEICE
Oearnaley, D.P.
Nactln, B.P.S.
19"»e
Proudfoot, t.T.
Stewart, n.S.
Levitt, T.
Hlddop, B.
1919
Okonek. 3.
Rofsaan, 1.
Renningsen, B.
1976
Bares, V. J. , Jr.
Vaughn, ».«.
1977
Bayes, l.J. , Jr.
Vaoghn, I.K.
1977
Rayes, (.
-------
<.«'-Bipjrr
ci2-ai«-i2
It 1IC, If 300 C (tecoip)
(COITIIOED)
TISSOB
3395
Udn*r
3396
ti»«r
3397
1*09
3399
SplMD
3399
OtlM
Eiroson toon
.
iBunxcAL
HTBOD
-
•OBBXI
or cisBs
, -
1
•1 i
b| 1
1
1
1
UHI
0.057-0.062 ppi
•) 0.015-0.028 ppi
b) lot ippllcibl*
0.013-0.017 ppi
lot applicable
lot applicable
MM
0.060 ppi
1) 0.021 ppi
b) 600 ppi
0.015 ppi
0.010 ppi
SOO ppi
8EIEI1L IIFOIMTIOI
ling* i« for
Polionlig fitillty
eight lid left
EtSTICIDIS; U3BIXC; UKllOZtSl
CIISOI IIOIOMIC COSPOOIDS; D.OOD;
IITII: IIDIIT3I Hill; DI1IBJ LOKS)
IIHT; SPLHIs BIlIlj BLOOD 310BJ
TIKISSBB
• I C*M 1
b) cm 2
Volioitig
KSTXCIDBSi USHIC; HKilOItS;
CIIBOI IIOIOHIC coarootDs;
I It IE! KIDIBTSi Bill! OKI IE; LOKS;
BIIBT; SPLBII; BBtXIl BLOOD SIBOT;
TCIIBSSBB; C1SB BISTOIXIS
(olionlBj Iitilitr. lug* la for
rlgkt md left l«g.
lIsnciOBS; 1ISEIIC; UMLOItS;
CIBBOI IIOIOHIC COBPODIDS; ELOOD;
IXfBI; KXDIITSl BUI; 01X18; LOKSl
BHBT; SPLBBI: BI1II: BLOOD SIIOBj
TIBIBSSBB
PolMilig
PISIICIDE5; IISBIIC; UKUOXtS;
ciiaoi HOBOinc CCBPOOIDS; ELOOD;
IXTBI; KDIBTS; Bill; OBII8J LOIOS:
BIHI; SPLBBB; BHII; BLOOD SBROB;
lIllfSSEE
PalMDlag
EISfXCXOBS; tBSElIC; ILKILOXCS;
CIBBOI IIOBOtnC COIPOOIDSl ELOOD;
LITEE; KIDIIIS; Bill; OilIE; LOIOS:
RIMTl srtBHt BI1XI; BLOOD IE BOB;
IBIIBSS8I; CISB BISTOBIK3
nriuicE
Stj»m, I.J., Jr.
Tiagha, l.K.
1977
Tiaghn. *.(.
1977
t.J..
Tiaghi. l.K.
1977
Jr.
Taagka,
1977
I.J.. Jr.
l.K.
CO
B>r«s,
Taagkn.
1977
. J., Jr.
l.K.
-------
a.7-R«tk»o-1B-lndene. 1,2.3,»,5,6,7,e,*-oonachloro-2,3,3».»,7,7a-hexah7dco-, (lalpha. 2beta.3alpka, 3aalpka,abeta,7beta,7aalpha) -
39765-80-5
C10-H5-C19
B« »»a.23
TISSOB
3*00
kdlpom
3*01
Milk
3*02
811k
EXPOSURE iOOTE
iHLYTICtL
HETBOD
CC
OC
OC/HS
IOHBII
op cists
168
57
a) 10
b) 25
c) 35
d( 10
•t 20
fl lot
given
Banes
0.010-0.367 99/9
Trace-0.01 pp«
_ _
•) lot given
b) lot 9lren
e) lot given
d) lot given
•I lot given
t\ 1-2 ng/g
BBH
0.065 U9/9
.
<0.01 pp«
a) B9/9
b) 09/9
e( 19/9
4) nj/9
•1 H9/9
fl B9/9
nuipn iiroRiuTion
Canadiana Icoa Eastern Canada (16) ,
Q»b«c (50) . Ontario (57) , Ctntcal
Canada (22) and «eat«rn Canada (27) ,
1972.
PISTICIDIS; CBLOBIM OBOIIIC
CCBPOOIOS; OR; DItlDRII;
CCLTCBLOBIIITIO BTPHEITIS; DtB; ODD;
lOltCRLOB; BIMCBLCBOCICLORIHIB;
OIICHlOBDkllj BIPTtCBLOB EPOJIDE;
tDIEOSB TISSUE: CallOt
lactatlng «oun in iel*ct«d areas of
Ickanias and nisaiaaippi.
BILK; PESTICIDES; ADIPOSE TIJSOB;
8ITAB01.ITBS; CHtOPIIB ORCtllC
CCBPOOIOS; CBLOBII1TED HTDBOCABBOBS;
HCTITIOI; OZTCBlOBDall; DDT;
BOItCBlOB; BEPTtCBLOB EPOIIDI;
CIILDBII; BtUCBlOlOCTCLOHKIDE; DOB;
tmisis: MISSISSIPPI
a) Eastacn Canada
t) Qu«b«c
c| Ontario
d) Cantcal Canada
•) («*t«cn Canada
() latlonal average, saiple* above 1
ng/9
latlonal Snr*ev, 1975
EIPHEIIL COBPOOIDS; CAMDa; CRLOBIIB
CBGtHC COMODIOS; DDK; DDT;
CIttDIII; BCPTACBLCB BTOIIOE;
RKtCBLOBOBIIZEBE;
R1HCHLOBOCICLOHIIHE; ULK;
lOltCHLOR; OIICBLOIDIIE; PESTICIDES;
IOITCB10BIIITID BIPanTLS;
ECirCHLOBIlUIID TSBPHErtlS
BEFEREICE
Dei, J.
Caipbell, D.s.
Bobineon, B.H.
D«fl«S, D.J.I.
1917
Kutt, r.w.
Stra»sian. S.c.
Tobe, ».».
1976
net, 3.
Dailai, D.J.
1979
-------
•,7-nethanoiadaa. 1.2,«.5.6,7.8,e-octachloro-1.2-epoiy-3a.a.7,7a-t«trahjdro- (8 CI)
2.5-Bathano-2B-indano(1,2-b)oxirene. 1a,2.3,4,5,6a,7,7-octaCBloro-1a,1b.S,Sa,6,6a-tie>ahTdro- (9 CI)
26880-«8-8
C10-B4-CI8-0
n «23.77
TISSUE
3*03
IdipOM
3«0«
adipose
3*05
Bilk
3*06
Bilk
EXPOSURE BOOTB
AIALTTICAL
BJTBOO
-
cc
GC
GC-8C
GC/BS
...
IORBBI
or GUIS
168
898
57
a) 10
b| 25
cl 35
d) 10
e) 20
f| lot
EAIOB
0.003-0.336 ag/g
< or • 1.73 ppa
Trace-0.02 ppa
a) lot given
b) lot given
c) Bot given
d) lot given
e) lot given
f) 1-2 ng/g
O.I
0.
<0
a)
b)
cl
d)
e)
fl
nti
0.055 ag/g
0.12 ppa
<0.01 ppl
1 ng/g
1 ng/g
1 ng/g
1 ng/g
1 ng/g
1 ng/g
OBIHIL IIF01UTIOI
Canadian* troa Eastern Canada (16),
Coebec (SO). Ontario (57). Central
Canada (22) and eastern Canada (27).
1972.
PESTICIDES; CBLORIBB 0101ItC
CCBPOUIDS; DCT; ClfLDBH;
PCLTCBIORIEATED BIPBBITIS; DtB; ODD;
IOIICBLOI; BEUCBIOBOCICLOBEUIB;
OXICBLOBDAEE; BEPTACBIOB BPOHDB;
ADIPOSE TISSOB: CAIADA
II 197*. concentration on llpld
baala.
Poataortee and biopaiaa throughout
D.S.
BILK; PESTICIDES; ADIPOSE IIISOB;
BETABOUTES; CBLOBIEB ORGAIXC
COBPOOIDS; CBLOBIIATED BTDBOUIBOIS;
IACTATIOE; OXICBLOBDAEE! DOT;
EOEACBIOR; BEFTACfllOR BPOXIDE;
CmOltl; BEXACBlOfOCYCLOBBXAlB: DDE;
OIITBD STATES
Lactating noaan in selected areas of
Ickansa* and Biaalaalppi.
BILK; PESTICIDES; ADIPOSE TISSOE;
REtABOLtTES; CBLOBIBE OBGAIK
COBPOOIDS; C8LOBIIATED niDBOCARBOIS;
LICTATIOI; OXTCBLOIDABE; DDT;
IOIACBLOR; 8EPTACR10R BPOXIDI;
CKLDRII: BEIACBIOfOCTClOBEXAlE; DDE;
AtlAISASi BISSISSIPPI
a) Eaatern Canada
t) Quebec
c) Ontario
d| Central Canada
a) Vestern Canada
t) latlonal average, saaplaa above 1
ng/g
latlonal Survey, 197;
EIPRE1U COBFOOIDS; CABADA; CHLORIBE
CiGABIC COBPOOIDS; DDE; DDT;
OIHDBXI; BEPTACBLCII BPOXIDE;
RIXACBLOROIERZBIE;
BIIACBLOROCVClOBEXtBE; HI1K;
ECRkCBLOR; OITCRIORDAB8; PES1ICIDBS;
fCItCBLOBIHTtO BIPBEHILS;
PCLTCHLORIDtTtD TEBPBEITLS
(IEXT PIG El
1BFBBEIC2
Bes. J.
caapball, D.S.
Bobinaon, B.I.
Davies. D.J.A.
1977
Katx, F.I.
Strassaan, S.C.
Tobs, A.B.
1976
Rots. F.I.
Straasnan, S.C.
Toba, A.R.
1976
Bes, J.
Davies, D.J.
1979
-------
• ,1-IMtktBolndtB, 1.2,».5.6,7,8,8-octaealoro-1,2-«po*]r-3a,»,7,'7a-t«trahYdro- (1 CI)
2.5-!Uthano-2!l-lnd«no(1.2-b|o«lt»«», 1«,2.3,«, 5,6a.7,7-octachloro-1a,1b,5, 5«,6,6«-h«i»hTdro- (9
2«*RO-a8-B
C10-H-C18-0
II «23.77
(COHTIIOED)
TISSUE
411k. fat
EIPOSOIE BOOTE
tllLTTICIl
flETBOD
OC-BC
IOBBEB
OF CIS5S
a) 3«
b) 6
i
1,
1,.-. -
B1IOB
_ _. .
a) 0.03-0.70 ppi
b) 0-0. 12 ppi
BEII
•) 0.1) ppi
b) O.OSO ppi
IIF3»fllTIOS
•) High p«aticld«
t) ion p»»tlcid«
lo MO lirlog io Stickrlll.,
nlutlilppi (lo» p«*tlcld« asago and
Delta area (high putlclde au9«).
SaipUs lo 1973-1975.
BILK; PESTICIDES; DDE; DDD; COT;
BmCBtOIOCICLOBHIIE; HEPTtCHLOB
ECCZIDE; OXTCHLOIDtlE; DIELDHB;
tISSISSIPPI; COBPIHTItE BfllOlTIOIS;
BtlSOEENEtT BET HODS
IEFEBEICE
Batnctt. B.I.
D'Ercolt, ».J.
Cain, J.D.
Jetbur, B.D.
19T>
-------
a,7-Mtkaiol»4ai>, 1,a,S,6.7.B,B-k«ptackloro-2.3-«po»y-3a,«,7.7a-t«traBy4ro- (8 CD
2.5-B«tkaBO-2H-iidMo(1,2-b)oxlnB«. 2.3.4.5.6,7, 7-k*ptachlOEo-1a.1b.5,5a,6,6a-kUBkjaco- (9 CI)
10»-5T-J
C10-M-O.7-O
II 389.32
(XSSDI
3*08
UipOM
3*09
UipOOT
3*10
141 POM
3*11
idipo**
niosin MOII
IMLRXCtL
amoD
OC-EC
cc
oc
OC-BC
OC-EC
•nut
or CISB
•1 26
b) 22
Cl 27
41 18
•1 18
fl 13
168
•1 U12
b) 898
•1 20
b) 16
cl 22
4) 17
UMI
•1 <0. 0001-0. 0102 tym
b) <0. 0001-0. 0120 ppi
c) <0. 0001-0. 0770 ftm
A) <0. 0001-0. 0037 ppi
•) <0. 0001-0.037* ppi
f) <0. 0001-0. 13JO ppi
0. 003-0. *77 09/9
•) < or - 10.62 ppi
b) < or • 0.77 ppi
.
•) <0. 0001-0.7765 ppl
b) <0. 0001-0. 6353 ppl
C) <0. 0001-0. 5071 ppi
4) <0. 0001-0. ««58 ppi
(HIT
Bill
•1 .0030 ppi
b) .0007 ppi
c) .0005 ppi
4) .0025 ppi
fl .010* ppi
0.0«3 09/9
1) 0.09 ppi
bl 0.08 ppi
» 0.1110 ppi
bl 0. 1*«8
cl 0.11**
4) 0.0738 ppi
PIG!)
BIIIUI IIPO1I1TIOI
•I Bill* - •tiUbOtl
b) Hil» - 0-11 10
c) ««!•» - 70. yc
4) Mialll - •tlllbora
•I Pcialll - 0-11 10
(I f•••!•• - 70* yr
UtopiT «p«ciMii. 1967-1971. fcoi
Iirailli iltk 10 kBO«B occipitloul
•ipoian.
II5TXCID8S; IISBCIICIDES; CHIOBUE
OIBlltC COIPOOIDSi DDT; DDE; ODD;
DIUDIIIj BEPTtCBLCl EPOHDB; iDIPOSE
1ISSOB; XSIlELi IIUCBiOHOCTaOBRMB
Ciiilltni (cei Biitvcn C*n*4« (161,
OMb«c (SO), Ontiria (57). Cmtnl
C»«4i (22) U4 IxtKB C«n«te (27).
1972.
PISTICIOBS; CBL08H! OBG1IIC
C08MOIOS; OR; DIItDIII;
(CLTCH.OIIIITEO BIPBEITLS; OR; DOO;
ICItCBLOBj BUICBIOIOCICLOIIHII;
OKCRtOIDIII; BBPTJCBL01 BPOHOB;
IDIPOSB 1ISSOI; C1IIDI
•) Pt 1970
b) 197«
COICIBtCltlOBI OB
blltl.
Poitioctcii »4 blopiiii tkrnqhoat
U.S.
BILK; PESTICIDES; IDIPOSE TT.!SOI;
BIHBOLIIE3; CBLOBI1B ORCIIIC
COBPOOIDS; CltOIIIiTBD BTDBOC48BOBS;
IICTMIOB; OIKIlOIDtll; DOT;
ICIIICBI.OI; BBPTtCHOI EPOXIDI;
CIILDBII; imCBIOIOCTCLOBHIBB; DDE;
OBIT8D STHIS
I) 0-» JI 014
t) 5-21 1C 014
c) 25-«« 1C old
d) «5» re o!4
Otlnc J«t«
lotopil«4 tluoi (1969-70) ftoi
Io4t*i4itli "ltd ic kBova
occipitlonil «po»ir« «ho had Ilm4
IB th« Kaipili ci9loa of 09aB4a.
FtSTICIDBS; CBIOIIII OIOMIC
CCBPOOtDS; OR; DIELDBIl; BEtTtCBLOB
ttOIIDB; IDIPOSE TISSOJ; OGiEDl;
BlIICBlOBOCICLOBEZtBE; ODD; CDE
•EPEIBICE
•aiwriiBB, 8.
Toiatls, L.
Iasa*raann, D.
Day. I.E.
ecoMr, T.
laxacoTlci, 5.
|OMB(«14. 0.
197*
B«s, J.
Caiptoll. D.S.
BOblBSOB, I.I.
DaHra, B.J.4.
1977
stcaniiB. s.c.
Iob», K.I.
1976
Haiiiciann. B.
Toiatis, 1.
(asMtiann, D.
Day, I.E.
Dja*ak«rlan, B.
197«
-------
«,7-l|ath»nolDdan, 1,»,5.6,7, e. B-haptachloro-2,3-«poiY-3a,«,-',1«-tatr«hTdi:o- (8 ell
2,S-n*thano-2B-lndano(1.2-b)cclr*n*, 2.3,«,S,6,7.7-haptachl0ro-1a.1b,S,5a,6,6a-heiahTdro- (9 ci)
C10-B5-O.7-0
II 389.32
(COITIIOED)
TISSUE
3*12
tdlpoaa
3013
kdlpoaa
3»1»
adlpOM
3*1S
Blood
BTFOSORB ROOTB
'
Inhalation
taxation
tlkLTTICtl
HETHOD
OC-BC
oc
oc
IORBEI
or c»sss
•I 26
b) 39
C) 122
d) 99
•1 151
f| 70
•1 33
b) 17
1
•1 7
b) *97
BlIGB
a) lot gUan
b) lot glT«
c) lot gllan
d) lot 9lr*n
•) lot glran
f| lot gl»an
•I lot gltan
b) lot gitan
lot applicable
-
a) 2-17 ppb
b) lot gifan
mi
al 0.11 ppa
bl 0. 1« ppa
c( 0.11 ppa
d) 0.11 ppa
•I 0.12 ppa
f) 0.11 ppa
a) 0.20 ppa
b) 0.08 ppa
0.037 ppa
_
at 5 ppb
b) < 1 ppb
GEIIHL Tirol! RATIO*
a) 1961
t) 1972
c) 1969-72 (C«aal«a)
d) 1969-72 (aalaa)
• ) 1969-72 (Bailcan-laarican)
t) 1969-72 (DOB Hailc«n-»a«clcan)
Patlant* gndarqolog al«ctlT« mmgttj
la 1969-72 in th* low«t rlo Grand*
•allay of •onta«a*t T««as.
PISTICTDBS; DOT; BEmCRLOB IPOXIDE;
CILOIIIE OBCII1C CCIPOOIDS; IDIPOSE
TISSDE; TEXIS; REItCaLOBOCTCIOREIalE;
DIE; DDD; DIEIDBH; POLTCHIO !I»»TED
eiPHBIIlS
a) Occanland«c«. 20-74 ft old,
laaplaa takan daring acnta
lapacotoila*
b) Danaa. 1-75 fr old, auddan daath
tj aulcld* oc IB auto accldagta
Radian ralaaa, baaad OB llpld «t
lat wt valaaa avallabla.
Ocmaland nonlndaatclallzad area
Canaack Indnatclallzad.
ICIPOSE TISSOB; aGE; lOTOFSIES;
CBIOBIII OICIIIC CORPOOIDS;
P1STICIOES: ODD; DCT: ODE: DIELOBII;
BIPTICRLCB BPOXIDE; PO1TCRLOFII1TBD
tlPRBIUS; CORPaBaTIIB ETiLOITIOISi
fCPOLtTIOl tlPOSDBE; QIEEILtlO;
BCIHIK
Cogc«Btcatle> onchangad «-S« day>
a«tar lagaation ef 170.1 9 75*
dichlofaathlOB.
Sulclda attaapt br 62-fC-old aala.
SOICIOS; PlOIIDa; lOTOPSIBS; BLOOD
SEROI; HOIP03B tISSOEi LITEB; OiLL
BUDDEI; IIDIETS; fESTICIDES;
OIOHOPBOSPBltBS: BLOOD; DDT: DDE;
DIILDItl; BEPTaCBLCI IPOXIDE;
RIIaCRLOIOBEnBII; LaTME; ITOBOLOOIC
BllirBSTHIOISl BIOaCCOHOLkTIOl:
EETaBOLITIS
a) Saaplaa in ihlch haptachlcr
afoxlda >a« poaltltalr Idantiflad
b) 111 aaaplaa
Poataoctaaa, Tlcglala stat* Radical
Eiaalnaca ofClc*. 1972. abont K%
(coa (hit* aalaa, 30V fcoa black
aalaa, 15* (COB nalta Caaalaa, 10S
(COB black Caaalaa.
CRLOIIIB OBCkllC CCIPODIDS: CDT; DDE;
CIBLDIII; fIBGIlIt; BLOOD;
IISTICIDBS; •OLTCHtOniaTBD
tIPBEIttS; BBUCHtOIOCICLOBEHIB:
BimCUOl BPOXIDB; CBLOlIlalBD
RtDMCtlBOIS
BEPEBE»CE
Bocna, J.E.
197a
Jansan, G.E.
Clanaan, J.
1979
Datlaa, J.E.
Bargaat, 1.
rccad, T. B.
Raqna, p.
Korgada, c.
SOBBabocn, B.E.
Taclavak, c.
1975
Griffith. P.O.. Jr.
Blank*. R.T.
1975
00
(HIT PlOB)
-------
*.7-B**haBOlBdaa, 1,a.S.6.7.B.8-h*ptachloro-2.3-*poi7-3a(«,7.7a-t«tcah7dcO- (B CI|
2.S-l*taBBO-n-lad*ao(1,2-b)axlr*B*. 2,3.«.5.S.7,7-l,eptacl>loro-1a.1b,5.Sa.6,6a-h*I*hTdro- (9 CX)
102B-57-3
C10-B3-C17-0
BI 36*.32
(coninio)
TISSUE
3»16
Blood.
plUM
3*17
•load.
••EM
3*18
Ulk
3« 19
Bilk
3120
Bilk
— —
ixposoiB ions
IULTTIC1L
IBTBOD
OC
OC-EC
OC
OC
tic
BOB BEE
OP CISIS
28
21
57
29
IS
UMI
lot gltr*n
7-22 ppb
Tr«ce-0.03 ppa
lot glT*B
0.6-2.6 ppb
.
<»EIT
•Ml
0.0136 ppa
10.9 ppb
<0.01 ppi
0.0091 ppB
1.57 ppb
PH18)
CIEIUL iiroiunoi
Blghcr p*cc*ntag*B of organacblorln*
la**ctlcld*a sad PCB«« IB allk of
BCtkara 20-29 r*ara than 30-39,
•Ithoagh th* fora*r had lour !•*•!•
la plan*. Overnight vona had
lOaeC !•«•!• thBB «OB«B Of BOTBal
••Ight. IMldB«« cone«Dtc*t«d la
•ltr*Ct«d llpld* Of plBSBB BOd Bilk.
IBCBBll *OB«B 2-* d«T« «ft«t BOCBll
dlllTBCJ.
PISTICtDISi BLOOD PLISBt; 8IU;
FOPOIMIOI tlPOSDll; ISR1IL;
CBL01IIITBD BIOIOCHBOIS; tlEIOSj
ICC; DDT; DEC! DDE; MUCHLOIXIMBD
BXPIIITLS; imiCBLOl BPOIIOIi
BIHCBtOlOCICLOHHAlB
a*l«B. koBmbold Kith OB* oc Bon
••BbtcB la pwtlcloB iBdactr}.
(HldBBtB of (aid County. CO.
FISTICXDIS; DDT; DDE; LXID1II;
BCPT1CBLOB IPOZXDEi CBLOSXIE OBGUIC
CCBP001DS; OIB1DEU; BLOOD StHOB:
CCLOlaDO; DOST; BEIKBLOIOCTCLOBUUB
iBctBtlng tfoaca la B«l«ct«d acaBs of
IckaBBBs aad Rlulaslppl.
I!ILK; P1SIICIOBS; tDIPOSE IISSOB;
BITJBOLITBS; CBLOBI1B OBGIIIC
COBPOOIOS; CBLOBXIlTEO BTDIOC11BOIS:
ItCTtTIOIl OIICHIOBDHB; DDT;
ICI1CBL01; BIPT1CB10B EPOXXDI;
CltlDBIl; BH»CBlOKXrrCLOHBIIlB; DDE;
UltlStS; BISSXSSXPtI
Blghac p«ccBBtag«B of ocgaaocBlodna
iBBBCtlelda* aad PCB's la allk of
aathacB 20-29 r*aca than 30-39,
althoaga th* focaac had lovac lavala
IB plaaaa. Ofacmlght »oa«n had
lo«*r !•«•!• than «OB*B of ncraal
••ight. B*aldo*a ccnc*Btcat*d In
• itcact*d llplda of plaaaa acd allk.
Tacaall «OB*B 2-« daya *ft*c nocaal
d*llT*cr.
PISTICIDIS; tLOOD IltSIt; 1TIK;
POPOLITIOI BXPOSOBI; TSBkEL;
CILOBIIaTBD BIDBOCMBOIS; LIIIDS;
1GI; DDT; DCD; DDE; POLTCBLOIXIITED
eitBEIYLS; BIPTtCBlOB BPOIIDI;
BIXkCHlOBOCTCLOBIXMB
Kllk aaiplai, hoapltala In aiban
Calo. « aaa(l*a fcoa Balllnfdal, a
?all*y In aoithacn locvay. Bo
occupational «po*ac*.
BH.R; KSBCTICID1S; LlCTtTIOB;
CBtORIIUTCC ByDKOCtBBOIS; CHIOBIIE
OIGHITC COBPCDIDS; PESTICIDES; IORUI
BBfBUICE
.
PoUaavk. t.l.
Boa, a.
•aaaacaann, B.
CBCoa, S.
laaaacaaan, 0.
taaa*ch. C.
1977
Start. B.C., Jr.
tldrlch, r. D.
BcDoagall, ».0.
Bonne*. L.B.
197«
Hats, f.B.
StCBBBBBn, S.C.
loba. t.B.
1976
-
Pollahak, I.«.
BOB, B.
VasBtraann, n.
Cacoa, s.
(aaaaraann. D.
L*B*BCh, C.
1977
Bakk*n. t.r.
s*lp, n.
1976
VO
-------
• ,7-aathanolndan. 1,<.5.6,T,a,8-haptactiloro-J,3-«poj]r-3a,a,7,7«-t«traiiydco- (8 CI)
2,5-««tk»o-2R-lna«o(1,2-b|oxlr«ni, 2.3.«.5.6,7.7-k*ptackloco-1a,1b.5.Sa.6,6n-k«aki«ro- (9 CI)
102»-S7-3
C10-H5-C17-0
HI 3(9.32
(contidBD)
TISSOB
3«21
nilk
3«22
Bilk
3*23
all*
3»2«
Bilk. fit
BXFOSOBC 10 DTK
1I11TTIC1L
HETROD
OC
OC/8S
OC
ec-Ec
— ___
IVRBSI
or CUBS
12 of SI
a) 10
b) 25
e| 35
at to
•1 20
t) lot
gl»«n
•1 27
bl 10
c) 10
d) *0
•I 53
b| 33
- -
nice
lot glvia
• ) lot glvm
b) lot giTajn
c) lot glvin
41 lot gl«n
•) tot gl»«n
*) 1-3 og/g
•) 0-0.008 ppi
b| 0-0.21 ppi
c) lot glvn
d) 0.001-0.00* ft*
1) lot d«t«ctabl«-0.060
SP»
) lot datactabla-0. 113
PP>
tmm
BUI
0.0027 ppi
•» 1 ng/g
b| 1 ag/g
o) 1 ng/g
dl 1 ng/g
•) 2 ng/g
0 1 ng/g
t) 0.007 ppi
b) 0.003 ppi
c) 0.002 ppi
d) 0.003 ppi
•) 0.002 ppi
b) 0.028 ppi
GEIIttL IirOBIlTIOl
laodoi 3«b]«cti of gnat«t St. tools.
RC, iitcopollton cm.
PISTICIDES; CBIOBIIB OiGHIIC
cogponiDS: DCT; DDE; OIEIOIII;
HIItCRlOIOCICtOBUtlt; REPTICBLOI
BIOKIDBi BUR; BISMOBIi COHCtRtTIfC
l««10tTIOIS
*) Eastern Canada
t| Qu«b«c
c| Ontario
d| Central Canada
•) l»tocn Canada
() lational a*«rag«. saiplvi abo« 1
«g/g
litlonal Sat»r, 197S
CIPBBITl COBEOOIDS: OIID1; CRLOBIIZ
oioiiic coacoaiDS; DOB; DDT;
DIILDIII; BIPTICHL01 IMZZDS;
BlIlCBLOaOBEItElI;
BIIlCBMIOClCUBIZUBi BILK;
IOI1CRMI; OIICRtOIDUBi PBSTICTDESi
fOtlCBLOaiUTID 8XTIMTLS;
EC1TCBLOBII1TID TCIPBBITtS
a) Cotton, cccn, nnd a«««M-gco«lng
at«a
t| Cora ac«a
c| Banana ana
1) Coffi«-gcmlag ac«a. Bl SalradoE
a)-c) In Siatciala. Ilgk««t »• of
p«atlcld«« on cotton
fonn fcoi leu lnco» fulllac In
laatoiala, and Bl Sal»ador. cbOMB to
[«p»mnt dlffcrint ligr««* cf «•• of
paitlctdca.
o*»a«« of pxtlcldac a partlcalac
(roblin In tropical coutrl«i.
fc««al«nc« of uliatcltlon lay
contclbat* to btaltk •(facts.
ICIICOLTOBB: CB1OIIIB OBGallC
coiPooiDS: cior DOSIIIG; DDT;
DlILDIIli Bl SILTtDOl; FOOD
COBTIRIIkTIOli SOkTBRkLa:
BIIaCRIOIOCTClOBIXlIC: RBPTtCBLOS
IPOZIDB; ZISECTICIDES; Bill!
IIITIITIOIM OEriciiiciBS; PBSTICXDIS;
IISTICIOJ BI3IDOIS
, _ .
a) 1966-1970 Itadj
t) 197 VI 978 itadr
1966-70 patUntl (OnlTusltT of
llbacta Bospltal). 2-10 dar»
Fostpartai. 1977-78 patlants (pmbllc
ntaltk off lea of tltacti) , T7-309
dafi poitpactu. I«sld«c«i, Edaonton
ot llbarta.
BTM| PISTZCZDIBS
aiziCBLOiocicLoaniiE; ODD; CDS: DDT;
Diitoni; Bimcatci BPOZIDB;
BtZlCBLOIOIBISBIt: CMkDli
(OlTCnOIZItTBD BZPRnnS;
CCBHHTIfB ET1LVITIOIS
BEPEBEICCE
Jonsson, T.
tin. G.J.K.
anbrutoE, J.
Uattalhnt, L.L.
Dcackar, B.
1977
KM, J.
DaTl«s, D.J.
1979
d« Caapos, a.
Olsirna-Bar zf» , I.E.
1979
CatcU, B.».
KadU. f.l.
Bnltkraltz, I.E.
cinalngkii. e.B.
Bran*. «.l.
1979
ON
W
O
-------
«.7-B.th.Bolod«o. i.«,*.«.7.e,8-.«pt«c»loro-2.3-«poi[y-3«.«.7.7«-t«tr«hyaro- (• CI)
2rs-B«th«BO-JB-iD(l««o(1.2-b|oilrM«. 2.3.».5.«.7,7-h«pt«chloro-U.1b,S,S«,«,6»-h«MkI«ro- (9 CI)
102»-S7-3
C10-M-C17-0
•• 389.32
(CORinlD)
nssai
3*25
•ilk. f«t
BIMSV1I BOOTB
IMtltXCH
BBTBOD
ac-ic
iMBM
or CISBS
•1 3*
b) 6
UTCI
•1 0.02-0.37 ft*
b) 0.01-0.08 pp.
•HI
•I 0.08 ppl
b) O.OSO pp>
QIIIML ZIKIIITXOI
•1 High pvsttcia* IMJ« *r«*
b| Lo« p*«tidd« «M9* •£••
IOMD llvlcg U 5tuk«ill«,
•i»l««lppl (lo« p««tlelta ••*!•) «ad
Belt* ur«« (high patlcld* ing*).
Saipl«« In 1973-1915.
•nit) PKSTICIDISl BOB; DDDj tOti
HUCItOBOCICMinilB! 8BPHCBW1
KOIIDB: OITCBLOlOlIBi OIKLOHI;
USSISSIPPt; COBPlltnTK BfllOHlOIS;
•IISOtBIBR BBTBODS
UFBISICB
Bunctt. B.I.
D'BECOl*, 1.3.
C«ln. J.D.
krtkit. B.D.
1979
01
-------
«,7-Mtka*oiad«M. 1,*,S.6,7.a.B-B«ptachloco-3a.*.7,7a-t«trakrdj:o- (I C
»,7-B«th«no-1B-tnd«i>«, 1.*.S.6,7,e,e-h«ptaeBloro-3a.l.7,7a-t
-------
«C-ttn*
31S-30-0
CS-B«-I*-0
•• 136.11. II 350 C
IX S3 OB
3*28
BlooA,
Mm
-
BIMSm MR!
lajcctiom
Xagutlaa
Hume*!.
BBHOD
Colorlntrr
•UTUtlc
IOIBII
or cisEs
*) e
M 7
uiai
1.inO(l-«l -3.8110(1-51 1
bl
Z.«S10(I-T)-2.2I10(I-<| I
nil
-
(I 4.2X10(1-6) •
b) 9.5110(1-61 I
6111111 IITOIB1TXOI
•I 60 111 «ft«t llJKtlOBB 0< 1.1-5.3
•I/kg
fe| 180 iln «ft«r ln]«ctiou cf
1.1-5.3 ig/kg
Ittimt* citb Ifiphou or otter «olU
ttrac*.
OlOaS; BIOOD SBBDB; IBOP11SB3: OUIBi
IiniBS; BITtBOLISRi RET1BOIRBS
urBiifCE
B*Bd«, (.
Ittttd B
Chthacr) B.
1978
OJ
-------
S-B*»«oi«olMC*tlc add. J- f*-chLoroph*nrU-«lph*-Mthrl-
51J3«-2S-T
C16-B12-CI-I-OJ
II 301. •»«
tISSDE
3*29
Blood.
plUM
3*30
OC1M
EIP0301E IOOTI
Iig**tl*a
Ing**tloi
II1LTTXC1L
RETROD
TLC
OC
TIC
OC
• on IBI
or CM is
e
... ,. .,
8
UKI
11.7-1.6 la<]U 100
•9 da** (4boot 1.« *9/kg) . t**k* In
•to«t 3 he.
B««Uhf ul«* t of *lagl* 100 mg do*«
11.2-2.0 ig/kgl *zec*t*d i« « «•!«.
•••Itkf •«!•• (••«n «*lght TC kg.
E«ng« S1-S6 kg) .
ClOaS; IITI-IIFLtHItTOIT »OBITS!
IIILOESICS; BRtBOtlTES; BIOCB
Plissi: nun
BEFEIHCE
Ch«t(l*U. D.B.
6n*n. J. I.
1478
Chttfl*U, D.I.
Cc**n, J.H.
1978
Ui
-------
5-thl*-1-«ublayclo(«.2.0)oet-2-mo-2-c*cboxrllc •eld. 3-((|S-Mthrl-1.3,»-thl«aiaiol-2-rll tfcio) ••tkn»-»-o»>-7-(2- (1B-t.tr«iol-1-Tl)«c«t««14o)- (8 CI1
5-Tkl«-1-MBtlefclO<*.2.0)oct-2-«M-2-e»boiTllo acid. 3-{<*o-7-((15-t«tr«iol-1-yl«c»tjl)«»ino)-. (O-tr»t|- (9 CI|
29933-19-9
C1«HM«-ia-O«-S3
•• »s«.s. it 198-joo c
TI33DI
3*31
BlOOd,
••COB
3*32
Illk
•itos»i toon
l«j«ctioa
Il]«CtiOI
1HLRXCI1
IBTIOO
Uocobloloflol
Uocobloloflcal
IOIBEI
or c»sis
20
20
UMB
lot yln*
1.16-1.51 <9/fel
•Bll
51.33 • or - 15.9
(«/•!
lot gl*on
CIIIUL IIFOIR1TIOI
'
2 kc iftoc U>ctlo»
Itctatlnf «o««n
IRIBIOTICSI DIMS; DIOB TIIUPT;
IDDlTSi Jirlli BLOCO SBIOB; OH:
nctinoi
2-« kc «ft«r lijKtiM of 2 «. P««lt
•t 3 kc.
lictatlag HOMI !• Jipu
IITIBIOTICli MOeSi DIM TBCHff;
t COLTS; J»P»I: BIOCD SBBOB; RLC
IICTITIOI
IIFERBICB
To«kloka, R.
CkO. I.
Tiklioto, fl.
B«C«T«K, s.
Skills*. T.
1979
Toskioka. B.
Cko. I.
Taklioto, I.
Bar«T*u, s.
SUlilV. T.
1979
Ln
-------
5-Thla-1-ax*blCTclo(l.2.0)oct-2-eae-2-carboiyllc
5-Tala-1-ainblCYClo(a.2.0)oct-2-ene-2-carboiyllc
C16-H16-I2-06-S2
B« 316. «•
acll. 3-(hydroxynathyl) -e-oio-7- (2- (2-talenylt acetaaUo) - acetate (eater) (3 CI)
acid, 3-( (acetylozy)aetayl)-B-oio-7-((2-tkienylacatyl)aelno)-. (61 -trans)- (° CI)
TISSUE
3*33
Blood.
serua
3»3»
tadoaetri
aa
3»35
OTacy
_
3*36
Oiidact
3«37
Otoras
EXPOSURE IOOTE
Injection
Injection
Injection
Injection
Injection
tBlLTTICaL
BET80D
Rlerobiologlca 1
Hlcroblologlcal
Hiccoblological
._
Hlcrobiologlcal
Hlcroblologlcal
IOXBEB
or CISES
12
s
6
5
10
BIBGE
1.0-7.3 ag/nl
1.8-5.0 ag/g
2.3-9.2 ag/g
2. «-«.•) ag/g
a) 3.0-12.0 ag/g
b) 1.0-8.0 ag/g
HEAI
3.1 ag/nl
2.2 ag/g
6.2 ag/g
2.7 ag/g
a) 3.6 ag/g
b) 2.3 ag/g
GEIEPAl TirORIATIOf
Surgical speciiens, <1.25-«.S5 hr
after 3
-------
5-thia-1-.«abicrclo<».2.0Joct-2-«aa-2-caeboKTlic acid. 7-J ta«lno-1.«-cyclok.«adl«n-1-TlacetTl|a«lao»-3-B«thil-e-o*o-. <6t-(6alpha.7».ta(B*M>-
38821-53-3
C«-B19-l3-Oa-3
If 3»9.ai. It 1*0-1*2 C fdaeoip)
TISSOB
3*38
Blood.
••tarn
3*39
OtlM
BXMSOBB loan
Iag*«tlom
Infection
AMI RICH
BinaD
Biceobloloflcal
Blccoblologlcal
•DBBBB
or CUBS
B
8
UlcB
-
•) 28.6-2.* ag/al
b) 3.7-M.9 Ofl/al
„
•) e».S-1126.6* of dot*
b) 80.7-96.31 of aos«
BB1I
. ,-—
a) iat gl»«n
b) lot 9i»«D
•) 103.2 » or - 9* of
dom
b) 89.7 » or - IK of
lot*
GEIEBU moiatnoi
*) B*DJ* of mas 71 and 2*0 «in
• ft«c 1 9/« br. Initial vtlM. 3.0
ng/il «t 15 ila
t) la>9» of M»* 15 and 81.! (In
aftor 2 9/« he. Final nlao. 7.6
ag/il at a ar
Btalthf »ol«nt««c« 22-32 yc eld.
DI08S; DIOG TRBIIPT; aRIBIOnCS;
BtOOD SEIOBi tOOITS; IBI tOBIJ
COIIBCTICOTi COBPlRtTIVB KT1I01TIOIS;
oiiiB; urecTioi
a) 7 do>» cf 1 9/» he
t) 5 do««» of 2 9/6 he
I«cova)cl««. bat>«*n dos*a and 2* he
aftcc final do««.
Baalthr »olont««ra 22-32 jc eld.
DIOOS; 0106 TBBItPT; AITIBXOHCS;
HOOD SBIODj »DOLIS; IBI IOBH;
COIIBCTTCOTI ComiaTIfB BTalOkTIOIS;
OIIIB; IiriCtlOl
IBFBBBICE
Choc. B.
Qulntlliani. 1.
Cnnha, B.«.
Thonpaon. B.
Flnkelataln. B.
llghtlngal*. C.a.
1979
Cho*, B.
Oolntlllanl, p.
Canha. 8.1.
Thoapson. B.
Flnkclataln. E.
llghtlnjala, C.
1979
-------
S-tfcla-1-a«eblC7Clo- ( («»looph«nyl«c«tyl) ««
!3«9»-T3-3
C «-BU-Cl-iJ-0«-S
il 367.83
| -3-ckloro-l-oio-. (6l-(6alpha.''beti (
TISSOE
3MO
Bleed,
aer»
3M1
Orlne
BIKSOBB tOOTI
Ingestlon
Ingestlon
imnicai
BBTflOD
Hlcroblologlcal
_
•Icroblologlcal
IOIBBI
or cis is
10
15
11108
•) 6.09-2.«« ag/al
b) 12.8-4 ag/il
a) lot given
b) lot given
c) lot 9iT«n
11 lot gltea
•1 31.R-18.6t of d«ilr
iOM
f) «0. 6-22. 2% of diilf
do««
HEII
«) lot giv«B
b) lot giT«
•I »3t of do««
b| «S* of don
c) «3« of tarn*
a) «B« of torn*
•I lot tpplicabl*
f) lot applicable
CEititL nrrmtTioN
•) lange of i««o< 1 aad 2 ht after
250 iq. Initial Talae. 1.8 oq/al at
O.S kr
t) Paaoe of leans 1 and 2 ht after
<00 ag. Initial value, 1 ng/al at
O.S tr
Clearance IT • br.
locaal Tolanteen age* 22-62 fr.
alTIBIOTICS; DIOCS; DIOO TDEUrT;
•COLTS
a) 0.8 ar. 2'0 ag
bl 0-2« kr. 250 ag
c) 0-8 kr. 500 ag
d) 0-2* kr. 500 ag
a) Mean dallj excretion day U3, 250
ag q. l.d.
fl Rean daily excretion day 1t3, 500
ag g.l.d..
locaal volunteer* ages 22-62 yr.
IITIBIOTICS: DRUGS; OBOI5 TDEHPT;
ICOITS
RtTEBCllCB
n«y«c«, B.P.
Hlrachaan, s.Z.
Voraser, C.
Cartenberg. s.
Srnlevlteh, t.
1978
Beyers, B.R.
llrsckaan, s.Z.
loraser, G.
Cartenberg. G.
sralevltch, Z.
1978
00
-------
S-Tki«-1-»Mblcrclo{«. 2.0)oc
3MM-01-*
C18-I18-IC-05-S2
Bf 462.5<
•cU.
-. (61- (ttlphi. 7b«t* (!•) ) | -
rxssH
3M2
aiood.
plus*
BHOSOH Mm
,
XBjactlai
lULRICIl.
inwD
Bicroblologic*!
I0BBB1
or CASIS
-
16
ilifli
•I 112.0-312.0 ig/fel
b| 32.5-92.0 «g/Bl
e) 5.7-39.0 •»/»!
mi
*l 172.3 ag/il
b) 52.7 ag/il
c) 18.9 «»/•!
GBIIUI iiromrxoi
-
•1 2 Bin «ft«r Ufailan of Any
b) «2 •!• »«t«r iBfutw-jMt twfor*
bfpan
c) 172 «l» ift«r loCuion-jiit »ft«r
b^pun
Iich f«l«« (at 1* 4oM« tnttod «lth
20 nA«.
11 •*!». «*«ng« tg* 51.9 ji,
•••rag* >t 83.0 kg. 5 (••*!••,
•>«ctg« «g« 55 yr, mng* »t 68.3
kg. all «lth •Bgii«l ktTiag nph«iOD«
»«ln brp««* Hcgcti «t th« a«diol
College of TltglBlt.
DIOaSi DIDO TBEItrT; kltlllOnCS)
HOOD ttlSBki SDlaCITi TliOIIH
lETBinCB
Polk. I.B.
lrck«c, G.I.
lOKCC. 1.
1978
Ul
VO
-------
S-Thla-1-a«ablcYclo(«.2.0)oct-2-eBe-2-carbosYlic acid, 7-(2-asino-2-phenYlacetasldo)-3-sethYl-"-o«o-, D- (8 CI|
5-tk.ia-|-a«abiCYClota.2.0)oct-2-ene-2-carbo*Yl.lc acid, 7-( (aein.ophenYlacetTl)aslno| - J-eethyl-8-o«o-, (6R-(6alpha.7b<>ta ft*)))- (1 ci(
C16-R17-I3-0«-S
n I«T.«
TISSUE
3M3
Blood.
seru
3M«
Blood,
serui
3«»5
Blood.
serui
3»«6
Blood,
serui
EXfOSDIE ROOTS
Ingestlon
Ingestlon
-
Ingest ion
Ingest ion
AlAtRICAl
RRTROD
Riecoblological
Ricrobiologlcal
Hlcrobiologlcal
IOHBEI
or CASES
a
18
IS
•1 11
b) 9
RAIGE
a) 2.7-33.2 og/al
b) a. 6- SO. 5 ag/il
a) 19-20 ug/il
b) 20-25 ug/ll
a) 10.1-35 ng/il
b) 5.8-27 ug/il
c) 12.6-25 ug/ll
d) 18.5-22.5 ug/ll
a) 23.4-0.5 ng/il
b) 8.7-0.3 ug/ll
HEAI
a) lot glvea
b) lot given
a) lot given
b) lot given
a) 19.5 • or - 3.0
ug/ll
b) 19.8 • or - 3. a
ug/il
c| 2«.7 » or - 3.7
ug/il
d) 19. • » or - 2.2
«q/sl
A) lot given
bl lot given
CIHRkl IIPOIHITIOI
a) Bang* of naai 15 and 65. ! lin
attcc 1 g/0 hr. 1.1 ug/«l at « hr
(Uaal »«!»•)
Hng« of >«ina IS and 83.7 >ln after
2 g/6 hr. 4.1 ug/il at « hr (final
tain*)
R«althr »olint««r« 22-32 yr eld.
CIOHS; DRUG THERAPY; UTIBIO1ICS;
BLOOD SEIOH; IDOLTS; IE! TOIf;
COIIECTICOT; COdPAItTITE EUIOITIOKS;
DIXIE; IITECTIOI
a) Range of i«an peaks after capsule
b) Rang* of Man peaks after
•••pension
Doses of 25 eg/kg/bodr *t
Infants and children vith
beiatogeBoes osteoiTelltls or
•appBratl«e arthritis at hospitals In
Dallas, Texas.
OROGS; BLOOD SEION; 0^01 THBHPI;
CtSEaSES; CHIIDRBI; IIPIITS; TEIAS
a) Peak lerel-2 hr. Drag IB capsule,
patient tasting
t) Peak leTel-2 hr. Drag In capsule,
patient ted
c) Peak level-O.S hr. Drag in
•oapenslon. patioBt fasting
d) Peak le*el-O.S he. Drag IB
suspension, patient fed
9 patients In a) and b), 6 it c) and
d|
Dosage: 25 sg/kg
Phanacoklnetie data available
3-10 yc olds, part of evaluation of
cral antibiotic therapy for
csteoeralitls and septic arthritis of
childhood.
ORtnS; DI06 TRERtPY; IITIBIO1ICS;
BIOOD SEROHl CBILDIEI; ADOLESCBRS;
CClPHITtVE ITaLOATIORS; THIS
i) Pasted 2 hr befcre and after dose,
lean peak (23.* ug/sl) at 0.! hr
II Taken Kith 118 si eilk or fonula.
•ean peak (9.0 ag/sl) at 1 hr
tang* of leans 0.5-6 hr after IS
•g/kg. lo effect of feeding on
haIt-life
1C9 studies «*r* dene «lth 106
Infants and children.
Infants and children tilth slid
•acocutaneous infections, otltls
•edla, and pharyngitis, ages 2-46
•oaths.
IITIBIOTtCS; CBXLDRII} POODSt BLOOD
StRORs StLIVli TEARS; TEX1S; IMPARTS;
COHPAIATtfl miOATIOIS
(IRR PAUB)
Choir, K.
QaiBtilianl. P.
Canha, B. A.
Thospson, K.
Plnkelsteln, I.
lightingali
1979
C.R.
Tetzlaff, T.P.
Hccracken, C.H.
Kelson, J.O.
1978
Tetzlaff, T.R.
RcCracken, G.B., Jr.
Thosas, R.L.
1978
RcCracken, G.H.
Ginsburg, C.R.
Clahsen, J.C.
Thosas, R.L.
1978
-------
5-Thia-1-a«abicyclo(»-2.0)oct-2-aaa-2-carbo«ylie acid, 7-(2-aslBO-2-pianjl«catasldo|-3-a«thyl-8-o«o-, 0- (8 CXI
S-Thia-1-asablcyclo(a.2.0>oct-2-ane-2-carbo«yllc acid. 7- J (aainophanylacatyl)aalno) - 3-Mthyl-8-OIO-, (6I-(«alpha,7bata (B»M I - 19 Cl)
15686-71-2
C16-B17-l3-Oa-S
•I 317.«
(COITIIOID)
TISStlE
3M7
Saliva
3«8
309
BXPOSOHB BOOTB
lB9«*tlon
Ing««tloD
Ingtctlon
..
lIlLTTICiL
BBCTOD
Bicroblologlcal
ttcroblologlcal
•iccobiological
IOTIBBI
OF C1SES
20
IS
B
I1IOB
0-1.5 «g/sl
0-4.2 ag/al
t) el.t-100.8* of torn
b) 87.3-9S.6X of 4f»«
•Ml
lot gl»«n
lot gl»«n
«) 91.1 » or - 7.6«
of don
b) 91.9 » or - 6.61!
of do««
OEIII1I. IIFOIIMIOI
Citrtll rang* 2-6 hr aft«c 1< ig/kg.
B€«D p**k 0.5 ng/il. lo «f<«ct of
(••dlBf
164 stadlM ««r« dona «ith 1C6
InfutB and chlldrao.
Infanta and chlldcan tilth aild
aacocotanaooa infactlona, otltia
aadia, and ptaErngitl*, agai 2-«6
acotha.
IITIBIOTXCSi CRILDBII; FOODS; BLOOD
smoa: stiiiat TBkis: TEUS; nrnTS;
COHPIBItXVB BflLOkTIOIS
o««rall ranga after 15 ag/kg. laan
paak 0.9 09/al. lo affact of faading
169 atadiaa »ac« dona vlth 106
infants and chlldcan.
Infanta and chlldcaa vlth aild
ancocataneoaa infactlona, otltia
tadla. and pharyngitis, agaa 2-«6
aonths.
iniBIOtXCS; C1IILDBBI; FOODS; BLOOD
siioa; sum: TBtis; TEHSJ nrt»s;
CCBPilltlfE eULOtTXOIS
a) 1 dosaa of 1 g/» hr
t) 5 dosas of 2 9/6 hr
tacoverias, tatvaan doaas and 2* hr
a (tar final doaa.
Baaltay *ol«ntaars 22-32 yr eld.
D1D9S; DBOG IHEBaPT; (ITIBI01ICS;
BtOOD SEBDB; tDOLTS; tW TOBK;
CCIIBCTICOT; COBUBJTITB BVUOITIOWS;
OIIIB; IIFECTIOI
IBFIKICB
IcCrackan, G.B.
Ginsburg, C. H.
Clahsan, J.C.
Thoaaa, 8. 1.
1978
Bccrackan. 8.B.
elnsbarg, C.H.
Clahsan. J.C.
Thoaaa. a.L.
1978
Chow, H.
QnlntlUanl. B.
cnnha. B.t.
Thoapaon, H.
Finkalstain, E.
lightingala, f.H.
1970
-------
5-Thla-1-aiablcTclo(«.2.0)oct-2-»n«-2-carbolylic acid, 7-(2-cyanoac«laaido|-3-(hydroir««thyl)-8-oro-, acvtat* (ester), lonosodlgi salt (1 ci)
?-Thia-1-tMblcyclo{».I.O|oct-2-»n«-2-carbo*Ylic acid, 3-((acetyloiy) aethy 1|-7-((cyanoacetyl) «at no)-B-oio-, aonosodloi salt, (69-tcans|- (9 ri)
2323°-»1-0
C13-H13-I3-OC-S.U
III 361.31. at ri»m but, n««dl«s fcoa acetona and ether, 168-no c (d«coap)
TISSO«
WSO
Hood,
••COB
3»f1
Orin*
RIPOSOIE ROOT!
Injection
Inaction
alUTTICU
BtlHOD
Hicroblolo^lcal
Uecobiol09le«l
IDRBEI
or casjs
10
10
ItlOE
a) 25-05.5 ug/al
b) 12-11 U9/al
•I 688-111* 19
b) C03-477 if
HEM
a) 35.3 H9/il
b) 25.3 09/1!
a) "I* 19
b) 7(9 19
IFIlfM. IIIFnBIATrnK
a) Thlqh U]«ctlon
b| *attock injection
Faaki (at 30-«S a\lo) a(t«c 1-9 dos*.
Hialthr ial«l (8) and feaales (2) ,
adalt (olantaer*.
CI06S; tlTIDIOTtCS; BLOOD S'FOI;
OVIIE; OIITCO KII6DOR; COXPtHTITE
tf«LO«TIOIS
a) Thigh injection
t) Buttock 6-hr deration after 1-9
don.
Rtalthy aal» <8) and taaalei (21 ,
adalt Tolantvecs.
CBOQS; IITIBIOTICS; BLOOD SEF01;
OITIE: ONITID KIIRCOK; COB?tf«TITE
EttLOtTIOIS
rtmr.rct
B«e*««, 9.S.
fynatec, H. J.
VlM, 1.
vhitaacBh, T.P.
147a
peeToa, D.s.
Byatcc, r.j.
«!«•. B.
UhltMcah, T.P.
19ia
NJ
-------
Sbota-Cardanolldo, 3b*t«-((O-2. 6-dld«OKT-|>«ta-D-rlbo-hoiopTr«iioayl-(1-»)-O-2,6-dld»oiT-b«ta-n-ribo- k«oprruo*rl- { 1-<|-2.6-dld«oiT-b«ta-D-rlbo-btzopfrano«
(9 CI)
3766-76-3
C41-B66-013
II 327.67
-hydrox?- (8 CX)
(3b«ta,Sb«t«)-
TISSUE
3*52
Blood.
pla*M
BXPOSDH tODTB
Ia]«ctlo>
iniTTICH,
MTROD
ncns'
IDBBSI
or CM is
•1 1
bl 7
UMB
•) <0.5-1.7 09/1!
b) 6.*-12.« n?/«l
ntB
•) lot gir««
b) 8. 9 ag/il
811(111 IROIBtTXOB
...
• ) P«tt»t< Kith DO E«Ul
l»afClcl«acT
t| Patlnti tilth r«nil ln»fUci«acr
Bialtkr
-------
5R-Crcl.ooct(b)lBdole. 5-(3- (diaethylaBlno) pcopjl) -6,7. 8,1.10,11-hexabrdro- (8 ct|
5H-CTClooct(b|lndol«-5-prop«o«alne, 6,7.8.9.10, 11-hershydro-«,l-dlaethyl- 19 CI)
5560-72-5
C19-H28-I2
HI 28».«3
TISSUE
3»53
Blood,
plasaa
3»5»
Uood.
•hole
3*55
Orine
BIPOSOIE ROOTS
IngaitiOn
XngestLon
. -
Ingeatlon
klftLtTXCIL
RETROD
ftadioaetcy
nc
Radioaatcy
we
Badloaetey
RBHBES
or ctsss
12
12
12
IklBE
0. ao-trae* ug drug
•qui»/«l
0.2«-tr«c« ag drag
•qai*/al
a) lot ql»en
b) lot givcB
BB»»
lot giveB
lot gl»en
a) 3«.7S
b) «1.9(
QEIEB^L I«rOBB»TIO»
2 and 06 be after 35 19, labi
doie. Trac* at 0. ! he. init
talue. No HBchangad ipclado
d« tec tad at 2 be.
Dialtbf lalaa
OI01S; (IETHSOLITBS; BIOOD; 81
PUSBl; ORTIE; PECES; COHPAB
EKLOtTIOIS; HTIDEPPESSIfB
2 and alt be aftec 35 ag, labi
do««. Trace at 0.5 he, inlt
falue.. So unchanged deng a
Bealthr lalea
CIOGS; 1BHBOIITES; BLOOD; B
PUSH*; ITtTHt; FECIS; COHPlB
Ef*L04TIOIIS; »»TIDEPRBSSITE
a) 0-2« be
b) 0-168 be
1 of dose attec 35 ig. Beta
ccnvecaiea and conjugation e
21. 5^ of dose In 0-168 be fe
R«althy *alei
CBOGS; HETtBOLITES; BtOOD; B
nasRk: amii; FECIS; COBPIB
mt.OaTTOI5: kBUDBPBBSSITE
Siaennine. S.r.
Tlo, c.o.
Fueling, P.V.
197<|
sisen«ine, S.F.
Tlo, C.o.
Paulina, u.«.
siaaavlne, S.P.
Tio, C.o.
euelins. H.».
1971
-------
(b,f)a**plB*-5-eu:bc»*la:*
2M-46-*
C1S-B12-I2-0
n 23C.26. If 20»-20« C
TISSOB
3*56
Blood.
BXIOSan BOOTB
XBgVltlOB
IMLRXC1L
IBTflOD
83
IOBBBB
OF CiSBS
3
"KB
12.1-36.3 UOlu/1
lot Jl»«0
eBIEUL IlfOBHlTIOB
OB do««« CBBgiog ftoi 8. 8-17. S
••olos/kg 2i/dBj
CblUc«B tc*«t«d foe psychoBctor
•Fll«p>r, tgu 10-13 ye.
Oodlllctbl* «id« •ffocts, it} IM
trnpoeaey.
PEICBOTROPIC DiaeS: OB DOS; DFOO
TBEBtPT; CBILDSBI; BtOOD PLISBt:
1IITOUS ST3I1B DISEtSES; OISHSBSj
IITICOnOLSkBTS) SIBOBI
BBFB1BBCE
aoetllsMB. L.
Hof«r. B.
Tybrlng. e.
Ostcclok, J.
Bin*. ».
1980
-
Oi
-------
fR-Dlb«n«(b,f)a««plne. 10. 1 1-dlhrdro-S-(3-(eethrlaalno| propjl) - (R CI)
;R-Dib*n«(b,f)asepine-S-propanaaiB>, 10, 1 l-dlhfdro-l-aUhjl- (9 CI)
C 14-122-12
81 266.37, BP f2- IT! C 0.02 •• Rg
TISSUE
3«57
Hood
3«5«
Blood,
plaaaa
3«59
nood.
piaaaa
3«60
••act
3«61
Line
EIPOSOIE ROUTE
Ing* at Ion
Tngeatlon
Ingeatlon
Ingeatlon
tltLTTTCtL
RETROD
GC
oc
OCyiS
oc
oc
IOHBB1
or ctsss
•I 1
b) 1
1
1
2.7-16.8 09/1!
•I lot 9lr«
b) lot gi*«n
c| lot giren
1) lot glTen
8-100 ng/»l
86.7 ug/g
1. 6- 29 «. 3 09/9
BEtl
lot given
>) SS.9 ng/«l
bl 62.» ag/il
cl 10S.2 aoVil
11 217.7 ng/»l
60 ng/ll
lot glfen
lot gi»«o
GEItlll IIPORHTtOW
2 of
«•••.
Tcicfcllc
f«t«Uti«s (Icom 961 swp«ct«d drag
•tUM c*«>» lnT»itlgat«] in San
Cisgo, ct. Jan to Cet 1978).
CBDQSi UTTDEP'ESSIT! tGZITS; BIDS
1IOSB; BLOOD; LIfEti H!1PT:
CIlIfCHU
a) 100 19 daily
fcl 100 19 daily
e| 150 ig daily
d) 200 19 daily
9-10 >
-------
SB-Dlb*>*(b.C)a»plM. 3-cfcloro-5-t3-CdiMt»rla«iQO)proprl|-10.11-dlhjdro- (B CI)
5B-DJ.b«K(b,f|aMpiM-S-ptopaaMlM, 3-chloro-10, 11-«lhydro-i,«-41»«tfcf 1- (9 CI)
303-«9-1
C19-BJ23-C1-B2
SI 31*.87, at 160-170 C at 0.3 n Bg
TISSOB
3*62
Blood,
plana
3«63
Blood.
pluia
BIPOCTSB BOOIB
lagaitioa
Ing* It lOB
luinxciL
BBTBOD
DC
.
cc
BOB BBS
OF CUBS
6
27
BIMB
a) Bot glToa
b) Bot gU«B
a) 77-587 niolu/1
b) 116-909 naol««/l
1MB
a) 20 ng/il
b) 7.5 ig/Bl
a) 201 n«olo«/l
8BIII1L IIMBHHIOB
Mtk - C be «ft«r SO ig
2* ht «(t« SO if
Bltll«t«<] fcoi giif
lBt«*ctlon nith nendnnallc
•tadUd.
Kalthy Tol»t*«c«, 21-26 Jl old.
OIBGS: HIIDBPIBSSITB IOBITS:
BIHBOllSH; BBT1BOIITBS; BWCD
SBBDIB
•| ChlOClllfMlM
t) 8*ttbollt«.
d«i«thrlcklocliipca*iB«
OacUg tklcl >k. on ISO »9/4«I
dlTld«d into 3 d«ilf dome. Sa
ttfoco loinlBg doit.
ilth pcliacy
llln»i. 19-6B it of «ge.
l«»«l of d«Mthrl ntabollt* dlnctly
cor»lat«d «ith icliof of d«[r*nioc.
DIOOS; HBTIBOLITE3; (BTIDBf BISSItB
IGIITS; BLCOC PLaSBl; BBOSOLC8IC
8IBIPBSTITIOBS; BBBaVIOB DZSCROBBS
BBTBRBBCE
Bora, K.-o.
JohnMon, G.
Jordo, I.
Landbocg, P.
Roan, o.
folin-rogollwrg, I.
1979
Traikain, L.
aabocg, B.
BirtlliioD, L.
Oronholi, B.
Bollstcoi. B.
Bockors, L.B.
Sjogvist, F.
Tbona. P.
Trbciag, 0.
1979
-------
$B-01bani(b.C)a ng/Bl
c) 190.3 ng/Bl
d) 221.7 ng/al
33 ng/al
a) lot applicable
b) lot applicable
moat
GEtfFIL IirORHTIOl
a) Parent drag
b) l-daaaathyl aatabollta
2 of 2" caaaa.
Iricycllc antldepreaaant overdoca
(atalitlea (fro a 961 aispact«d drag
acaoe caaea inveatigatad in San
Diego. CI, Jan to Oct 1978.
DROGS; alTTCEPIESSIVE HGESTS; DBOG
leosE; BICOO; LIVE!; HEIBT;
CUIFORIla
Death caaaad by drug coabinatlona
Racorda of 1239 daatha in 0.5. and
Canada. In all, dlazepaa or its
aatabolit* Kara praaent in tba
tlaauea and, in aoat casaa, tore than
ega drug vaa found, kgaa: laaa than
^-greater than 65 yr. High freqaency
of aalcide. Other data available.
Pulaonary and viaceral congeatlon
aoat coaaon poataortea finding
DIOGS; DIOG IBOSE; ClMOl; OUTED
SUITES; OTaB; SED1TIVES; BTPtOTICS;
ESTCBOTROCIC DROGS; BLOOD; LIVER;
KIDIETS; 11COBOLIC BEVBRaGES;
FOREISIC BEOICIIE
a| ISO ag daily
b) 150 ag daily
c) 200 ag dally
d) 200 ag daily
10 aaaplea each caae
Taloea are total tricyclic aainaa.
Outpatlonta treated for depreaaion.
CIOOS; alTIDIPIESSIVE tBEITS;
PJtCflOTIOPIC DIOGS; BETIBOLITBS;
flOOD PLaSllt; HIRED ST1TES
Patianta being treated «lth 150-300
ag/day. Betabolite deaipraalne
levels alao aaaanred.
IITIDEPBBSSUB tGEITS; DROGS; BtOOD
PlISBt: BEISORIBEIT RETHODS
a) 0.67 and • hr aaana. ajra|. Final
valua. 6.9 ng/al at 21 hr
fc| 0.67 and « hr aaana. tablata.
final value. 7.1 ng/al at 2a hr
all aabjacta received 75-ag ton* aa
2S-ag tablata or S ag/al-ayrap.
Sabjacta differed, K0.01. Syrup and
tablata differed only in lag tiae.
K0.05.
Raalthy Caecaaiona, ages 19-37 yr.
•itboat gaatrointeatlnal, hematic.
cardiac or renal dlaeaae. no druga or
alcohol «8 hr before to 2» hr after
at»4y. Taatad before and after doae.
DROGS; alTIDEPRISSIVE aGBITS ; BMOO
niSRl: IDOltS: C»I»D»; CORPIIinVB
EVaLOaTIOIS
L
5EFEBFICE
Milay, D.I.
Shan, B.F.
1970
rlnkla. B.S.
Iccloakey, K.L.
Goodaan, L.S.
1979
Ziaglar, V.E.
•ylle, L.T.
Blgga, J.I.
1978
janklna, R.G.
rrledel. R.O.
1978
Gagnon, n.A.
Oapaia, C.
Bertrand, a.J.
Ella, R.
Dogal, I.
1980
00
-------
SB-Dlbma(b.f)a*«pla*, 5-C3-tliB«thyla«iBO|propTl)-10,11-dUrdro- (8 CI)
SB-Dlb«c(b.f)a*«plB«-S-pEOpuaila<. 10.11-fllhjdro-l.l-diMthrl- (9 CI)
SO-W-7
C19-B2*-B2
II 280.«0. n 160 C at 0.01 n Bg
(COBTIBOBO)
TXSSOB
3«69
Blood.
plaaaa
3*70
Baart
3«71
Li»«t
ixrosni Boon
lagaatloa
Ingartloa
lagoatioa
IBaLRXCaL
BBTBOD
OC
OC
ec
BOBBBB
OF CUBS
6
2
2
BIIOB
a) lot glTM
b) Bot 9l»«
...
•) 3.2-82.7 ig/g
b) 35.2-«3.0 ig/g
•I 21.9-3U. 0 ag/g
b) 218.0-313.0 ag/g
BBkB
•) 9.0 ng/fel
b) 3.* ig/il
«) (at glv«a
b) Bot glT«>
•) Bot glftn
b) Bot giT»
eiBBUL IirOBIlTIOl
•) P*ak - 6 he «ft«r 25 19
b| 2* he «tt« 25 19
t«tl»t*d fcoi gnpk
lDt
-------
5B-->lbenxota,d)cyclohept«n«-delt«(1i,k
High correlation batveen single-dose
ae-hr and steady-state levels.
Patients vltb endogenous depnssion.
2J-71 yr.
CBOCS; (ITIOPP^ESSITE IAEITS ; «U>QD
(lean daily dose of 1-*5 ag/k; for sen
and 1.9 sg/kg for noaan. Por
treatsent. high levels less affective
than Intersediate levels.
Patients alth endogenoas depnssion.
HOGS; B«TTDZn«SSITE 1GEITS ; "LOOO
PLaSHt
"'"'""
rlegler, f.<.
vylie, L.T.
Biggs, J. T.
1978
Jenkins, B.1*.
rrledrl. P.O.
Robinson, D.s.
rooper, T. 1.
Pavarls, C.I.
Ives, J.O.
«les. ».
Partlett, D.
lasborn. 1C. 5.
1979
Braith«aite, f.
llontgosery, S.
Oavllng, S.
1976
Bontgosery, s.
Bralthvalte. P..
Bailing, s.
Rctaley, B.
1978
-------
1-Pcop*nailn«
72-69-5
C19-B21-B
•I 263.37. at 213-215
. ga»«a| -propyl««iB», 10,11-dikydro-B-B«tkrl- (6 CX|
3-ei0.11-ai»ydro-SB-dlb«Bxot«.d|cTcl.ok«pt«a-S-rl.id«B«|-B-Mtfcrl- (9 CQ
(COBTIIBBD)
TISSOB
3*77
Blood.
plUM
3«7B
Blood.
pltsia
Bxnsoii IOOTI
XagostlOB
TagHtlOl
IBILTTICIL
BSTBOD
-
ec-BC
DC/IS
BDBBIB
OF casts
10
*
UIOB
•I 20-«3 Dg/U
h) 15-50 og/Bl
c) 70-170 »g/Bl
d) 39-172 ag/kl
5.9-12.3 ng/U
•)
b|
cl
4)
10
BMB
32 Kg/hi
31 og/il
120 >«/•!
98 ng/»l
10 ag/«l
CEICIIL IIFOIIkTIOl
• ) Do«« «t 9 I.B.. puk« 3-12 kc.
noctciptyliM
b| DOM at 9 p. a., pMks «-2« he,
•ectclptrllnt
c) DOM «t 9 a. a., p«k» 3-« hr.
10-krdcoiTioitciptfllB*
d| DOM it 9 P. a., pMlu »-1S kc.
(••k« «ft«c 100-ig do***.
acaltkf *olODt*«r», ag«a 22-30 yc.
allomd to ««t 2-3 kt Mfoc* torn.
CMOS: aiTIBEPBBSSITB 1GEITS : BLOOD
CltSBl! aDOlTS; SBOaTITBSi
BfaioatToas;
E»k> >(t«r 7S ig
hrdcocUocidi. P«ak tlMS 8-1 1 kc.
tlUinttlon putllcUd bat lagg
• lltclptfllH.
BHltky »«ok«c«, agu 28-32 yr.
octkastatlc kypoMasloa
•nd >l»p. sjiptou p«ak«d it 2-6
kc.
UttDEPiBSSIIB aGIBTS; BLOOD PLlSBt;
I COLTS; DBOGS: DBOG TBBBaPt;
SIHBOLITBS
BBFBBEBCB
laktno, s.
BollUtw. L.E.
1978
Zl*gl«c. T.!.
Plgg*. J.T.
lrd«kant, a.B.
BOMB. S.B.
1978
-------
SR-Olbenio(*.d|cyeloheptone-AeUa,(R-dU>enxo(a,d|cyclohepten-5-yll4ene)-li.1-dlaethyl- fl CII
50-18-6
C20-B23-1
•I 271.31. HP Hydrochlorl.de 196-1V c
tissnn
!»•»«
Blood
3»80
llood
1«81
Blood
3«S2
Blood.
plasaa
3»83
llood,
plassa
StPOSniK SOIJTE
Ingest Ion
_
Ingest Ion
immcil
flFTROD
CC
SC
GC/HS
• m
OF C
1«
1
35
1
S
•I 0.1-5.1 ug/el
b) lot detected-6.5 tig/el
lot applicable
0.1-11*.} ug/il
a) lot l fat ql»»n
b) lot given
O.i if/100 il
7.0 ug/il
» 187.0 09/1!
b) 89.0 ng/il
c) 94.« ng/«l
83 ng/il
(•BIT ?»CB|
1FHEIHI, TIFO»B»TTC»
•) "acont Icuq
b) «-d<»lrthyl tetobollte
M of 2« cases.
tclcycllc antldepccasant ovecdow
fatalltlea (Ccoa "61 suspect «1 drag
ata«* casca Investigated In San
il»qo, .-». Jan-Oct
CVU'-.S; tlTTOEPICSSITE ITEHTS;
teasi>; HLOOO; IIVZF; H'lPT;
CILIfOIItl
Medical exaelnec case* at deaths froa
Intentional oc accidental 00, oc
undotecdned or natural caase*.
tJOr.S; «aiOPSl:s; I
SOTCIDE; BIOCD; 09TIE; LZfU; BILE
Death caused by dcag coeblnallons
«ecot4s of 1234 deaths In 0.S. and
Canada. In all, dlazepae oc Its
eetabollte vece present In the
tiasaes and. In coat cases, loce than
one dcag eas found. Iges: lass than
S-gceatec than 65 yc. High frequency
o( suicide. Othec data available.
Fuleonacy and vlscecal conge itIon
aost coaaon posteoctee findI eg
CB03S; n»nr, aBOSE: C»»»0l; OIITW
; SKDimns: RTPBDTICS;
OROCS; BLOOD; LIT IB;
(IDIEYS; klCOBOLIC
FCDEISIC REDICTRI
a) 100 eg dally
bl 100 ag dally
c| 100 eg dally
d) ISO ag dally
e-10 staples each case
fellies ace total tct cyclic aalnes.
OotpatLeets treated (oc depcesslon.
alTtCEPRESSIfE »G!ITS;
PSTCHOTBOPIC DROCSi RETaBOLTlES;
(IOOD PLISBJ; OiniD STkTES
Patients being treated >lth 100-300
eg/day aaltrlptyllne. Metabolite
nortrlptyllne levels also aeasared.
IBTIDEPRESSItE HCEIIS; DBOGS; BLOOD
PllSRl; REISOBEHEIT 1STBODS
Bailey, D.I.
Shan, °.r.
1970
Slek, T.I.
Flnkle, H.s.
RcCloskey, K. L.
Goodean, L.S.
Zlegler, v.E.
Sylle. L.T.
Biggs. J.T.
1978
Jenkins. B.C.
Fcledel. I.o.
H78
-------
5H-Dlben*o (a,d)cycloheptene-delta(5.gassa(-propyla«ina, 10.11-dlhydro-l,l-diaathyl- (8 CII
1-PropanaaliM, 3-(M.11-dlhydro-SB-dlben«o(a,d)cvclohepten-S-ylidene)-l.l-dlaethyl- (9 CI)
C20-B23-I
II 277.3*. at Bydrochlorlde 196-197 C
TISSUE
3*8*
Blood.
3»«S
Blood.
plasia
3(86
plassa
3*87
tone
—
BIPOSOIV 10UTB
Injection i
Tug* at LOB
iULTTZCll
BBTBOD
oc
GC
CC/1S
-K/.S
IDBBEE
or CISES
_
a) 8
b) 9
c) 11
d) 20
1
BltOB
a) 27-228 ng/sl
b) 25-236 ng/sl
c) 21-225 ng/al
a) 75-360 ng/al
b) 15-1*5 ng/al
c) 75-390 ng/al
d) 55-219 ng/al
10. 8-*3. ** ng/sl
lot applicable
nil
al 89 ng/sl
b) 86 ng/sl
c) 66 ng/sl
al 216.8 ng/sl
b) 100.6 ng/al
c) 258.6 ng/sl
d) 156.0 ng/sl
20.0 ng/sl
0.01 eg/31.8 g
GEIEMl IBFOBB1TIOI
a) 2 >k of treatsent
t) • ik of treatsent
c) 6 ik of treatment
Dose of ISO sg/day.
Ill patients had depressive 11 loesses
seetlng BDC criteria for prlaary
depressive disorder and "ere 19-67 yr
old.
DIOOS; IITIDEPBESSIVE «GEITS; BLOOD
tl»S!H; OROG TBEBaFy
a) Isltrlptyllne » nortrlptyllne.
after ISO sg/day orally. 31% as
nortrlptyllne
b) ksltrlptyllne » nortrlptyline.
after 120 eg/day 11. »8< as
ncrtrlptyline
ct Isltrlptyllne » nortriptyllne.
after ISO sg/day oral asitrirtyllne •
25-300 ag/day phenothlaxine. 56t as
nortrlptyllne
d| asltrlptyllne » nortrlptyllne.
after 120 sg/day III ailtrlptyllne »
25-300 eg/day phenothlaslne. 53t as
ncrtrlptyline
Steady state values. K\l patients
received 2. 5-«0 sg/day
benmdlaxeplne. Phenothiaiice
Increased nortrlptyllne levels.
Banges estisated fros graph.
Inpatients. ages 19-17 yr treated for
depression.
High taalltcn scores associated vitfc
high plasea nortrlptyllne. Ihe
curvilinear correlation greater in
patients vho also received
Fhenothlazlne. P<0.005.
CiUlS; tDTTOEPirSSIVE tCEXTS; HIVLTS;
F*AKCE; BLOOD Pl»Sf»; SSTIBOIISI;
•ITtBOLTTES
Paaks after 75 sg hydrocMorlde.
Feak tiaes 2-6 hr.
Bealthy aaokers, ages 2B-32 jr.
Croislness. orthostatic hypotension
and sleep. Sysptoas peaked at 2-6
hr.
IBTTDEPBESSITt tnERTS; ILOno PUSH;
ItOlTS; DB1GS; DBOQ Tt'«»Pt;
RIT\BOLITES
D«co«j"d «i yr old ihlta feaale In
California
Biasing 3 aonths.
CUSE "litOBTES; Dlins; XMTTniosrssiv
• GfllTS; CHLTFOBKH
BEFEBEBCE
Boblnsoo. D.S.
Cooper. T.B.
Bavarls. c. I.
Ives, J.o.
lies. ».
Battle tt, D.
laaborn, (.B.
1919
Tandel. 3.
Tandel. s.
illers, G.
Bechtel. P.
volsat. P.
1919
Ziegler, T. S.
Piqgs, J.T.
«r>leknnl, t.».
Cos*n. S.F.
1919
Kojochl, T.T.
nrleseaar. T.r.
19-")
(«!TT MIF)
-------
SH-Olb«nio (a.d|crcloh«pt»n«-A»UaH,qaaaa|-pcoprlaain«, lO.II-dihydco-J.I-dlaathrl- (1 CII
1-Pcop«naaln«. 3-(10.11-dlhrdto-Illt-dlb«BSO(a.d)cfcloh«pt«n-5-rlldan«)-l,*-dlaathrl- ft CI|
C20-H21-I
•I 2-»T.3'>. Ht Hydcochlotida 19*-19-» C
(COITIIOP.D)
TISSUE
3««8
Haart
3149
ti««r
3*90
lltejE
3*91
nuacla
EtPOSOP* POOtF
Ingest Ion
Tngeetlon
Tngastlon
llHYTIClt
IHttlOD
or
GC
ec/ns
«DBB!I
OP CIS5S
U
b) lot d«t«ct«d-21.2 tg/q
a) 2.•'-242.0 «g/g
b) «.2-«S6.0 ng/g
lot applicable
Rot applicable
al lot glvrn
bl Jot glT«
a) lot glt*n
b| lot glnn
10
0.8S 19/50 g
<) PacQitt dcag
b) 1-d««a«thrl ••tabollt*
1« of to caao.
Tcicycllc *nttd«pc«»ant oteidoar
tatalltlH
-------
xo(a,d)cyclok«ptan*-S-propylall», •-••tkyl- (8 CI)
so(a.d) cycloh«ptan*-:-propauiill«, I-Mtkyl- (9 CX|
5l-DlbM*o
SB-Dlbamse(a.
a39-60-8
C19-821-B
II 263.37. If Bydrocalocld* 169-171 c (cry*tal« fcot Uopropanol-athyl «t»«)
TISSUE
3*92
Blood.
pla*«a
HPOSOIB MOTE
Inge *t Ion
-
iiiLiMcn
HETBOD
ec
IOIBH
OP CaSBS
a) 1
b) 1
c) 1
MICE
a) lot given
b) lot given
c) lot given
a) 111.6 ng/al
b) lit. 3 ng/nl
c) 16*. 2 ng/el
CEIIIkL IirOIBHIOl
a) 20 ag daily
b) 30 >g dally
c) «0 ag dally
Steady-itate level*. 9-10 eaaplea
each caae
Outpatient* treated foe depcaaalon.
CIOOS; UTtDIPSBSSUB kGEITS ;
(STCBOTIOPIC DKOGSJ HEIIBOLIIES)
CIOOD PLkSBt; 01 IT ID STUBS
BB'BIEICE
Zlegler, T.B.
•ylie, L. T.
Bigg*. J.T.
-------
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114*
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KIPOSOM ".OOTB
lakaUtlon
llairtickt.
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OF C»5!S
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b) 2
c| 2
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a) 25-70 m/al
b) 20-25 B9/sl
c| 3-15 09/1!
d) 6-S9 K9/BL
•1 <6 09/al
b) 3-au 09/1!
1Ell
b) lot 9lT«n
c| 9ot 9ivao
d) lot gt»«n
f\ lot 9lT6D
•1 *ot 9iT«n
b| lot ii»«n
cl »ot 9lnn
— Gt«tP»l~ii(tn?i\Tio«
ci9«c«tt« with 5 aq ?t!C h) H««*r
saoKacv 40 ain aCtcc ciqacatt* ^Lth ^
a? TBC
cl llqht cacktca 1C aln aftai
ciqtcatt* "Hb « 19 me
4) "en? clioic pati«at«
«) Controls
CiO-.S; >StCROTB3PIC D"I-.S; BIOOO
FUSU: •tlSOBEItlT S-TIITOS: n^lnj;
mi'to KIIG9C1; sicKi";
• ) rlrat 2* he attcc cl^acattc mth S
19 T«C
fatlants
c| Coatcols
CIO-.S; PSTCSOTPOPTC SHIGS; BtOOD
flftj^^; 1F%SQSFSEIT ^'TR^OS; HHIVE;
OlfFD KI'GDQH; S1CKI«G
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.
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rocaaa. r.J.
lacks, f.
10'«
Tc«l«, J.D.
rlr.g, L.J.
flacka. T.
1=ia
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i| 6* fr old: ••» itctdr «tit« ultk
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b) 6* Jl oldi •••» «t««dr *t«t«
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«.10-S«cochol«sU-S,T. 10(19) -trl»ne-1.3.2Vtrlol. (1alpha,3heta.S3.->E)- (9
32222-OS-3
C2-F-B»»-03
BlOOl,
term
Urine
EtPOsnSE BOOT'
Injection
Injection
Tnqestlon
OT»
IRU.TTTCIL
HET10D
Ra
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9.10-3ecacholesta-S.7.10(19)-trlaae-3beta,25-dlol (8 CI)
9.10-Secocholeeta-S.7.10(19l-trleee-3,25-dlol, <3beta.5X,7B|- (9
19356-17-3
C27-H«»-02
gi aoo.65
tISSOE
3«98
Blood.
plaSSa
3«99
Blood.
•eras
3500
(loot.
serae
BiPosoBE IOOTI
Ingestlon
* Burnett
BBTBOD
Badloaetry
Bin
BDHBEB
or CISBS
•1 12
b) 10
•1 39
b| 1*9
BIBGE
at 70-118 ng/nl
bl 20-1 «B ng/Bl
«) 2.7-39.1 ngSil
b) 7.«-51.« ng/nl
a) 3.6-5.1 ng/a.1
b| Vot gi»«o
c) 10-* 0 ng/al
•Ml
a) 109 ng/al
bl 72.8 sg/al
a| 11.6 ag/al
b| 19.6 ag/il
a) a.s ng/al
bl 18.1 na/il
c| 19.5 ng/il
GEIIBIL IIFOSIaTIOl
a) B«altay adglta
b| Patients «ltk dUord«r«i) Ca
aatabollia
TaliMa ar« laxliai ri««a aft«r 10
ag/kg. P«aki at «-8 he.
12 »«althy adult TelantMC* and 10
F«tl«Dt« tilth dl«ord«r»d C*
••taboll» and/or gactcolntoatlnal
tonctlon.
flTlHIl D; BETIBOIITES; DIITID
IIIODOH; DISUSES: IDOltS;
CCBPallTITt IfHOltlOIIS: BIOCD ?USHt
•) Patient* ncalTlag anticocvalBant
tbarapy
b| Control*
Stfm of 39 had und*t*ctabl« l«»«Xa
(<• ng/il).
Idalt apil«ptlc patHnta attending
tk« noncology outpatient clinics of
Toronto Qsntcal and Toronto t* a tarn
lospltals. 23 asa and 16 nonn, aaan
aqa as yc (cangs 26-72 yr) .
nypocalctala, elaratad sacas • Hullo*
(bospbatasa.
Caccaasad bona aass
otciofl; nBTiBOiis<: CHSHOHWiyY:
CBCSPHOBOS; I'tTBBS;
BTDBOITCROlICalCIPtROLS; BIOCD SEBDB;
CCITRaL l»fCOS STSIt" OISEJSBS;
FHSmS; ClltDt
a) Contcoli (Tltaala D deficient).
cange Is range of leans fcoa
beginning to end of study
t| 3000 units of Titaain D2 in
capaales xeekly foe '• ao
c| Tltaaln-D- fortified flour for 6 ao
Kilans In Clasgo*. 20 adults and «6
children froi It faallles.
!cae subjects had blochealcal
abooraallties s>igqestlTe of cickets
oc osteosalacla.
CltCIO'; "ttJLS: 9LOOO SSP01; TITHH
C; »SH; 01ITBD KII-500H; IlinTIOHl
CtFICItWCIES; DTETS; COflPHBU'fE
MU01TI1IS: fITI1I«S
-
BBFIBEBCE
Staap, T.C.B.
197*
Pylypchok, 0.
Oreopoulos, D. 6.
Illsoa, D.I.
Barrlson. J.E.
Bclelll. K.G.
Beeaa, B.B.
Ogllvle, B.
Startrldge. '.C.
Bnrray. T.l).
1978
Pletrek, J.
Undo, J.
Preece, H. A.
O'Plordan, J.I. a.
1976
VO
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681
TECHNICAL REPORT DATA
(Please read Instructions on the reverse before completing)
1. REPORT NO.
EPA 560/13-80-036 A and B
2.
ORNL/EIS-163/V2/P1 and P2
3. RECIPIENT'S ACCESSION-NO.
4. TITLE AND SUBTITLE
6. REPORT DATE
Chemicals Identified in Human Biological Media, A Data
Base, Second Annual Report, October 1980
6. PERFORMING ORGANIZATION CODE
7. AUTHOR(S)
M. Virginia Cone, Margaret F. Baldauf, Fay M. Martin,
and John T. Ensminger
8. PERFORMING ORGANIZATION REPORT NO.
9. PERFORMING ORGANIZATION NAME AND ADDRESS
Health and Environmental Studies Program
Information Center Complex/Information Division
Oak Ridge National Laboratory
Oak Ridge, Tennessee 37830
10. PROGRAM ELEMENT NO.
11. CONTRACT/G RANT NO.
EPA IAG No. 78-D-X383
12. SPONSORING AGENCY NAME AND ADDRESS
U.S. Environmental Protection Agency
Office of Pesticides and Toxic Substances
Exposure Evaluation Division (TS-798)
Washington, D.C. 20460
13. TYPE OF REPORT AND PERIOD COVERED
Annual Report 9/79-9/80
14. SPONSORING AGENCY CODE
15. SUPPLEMENTARY NOTES
16. ABSTRACT
A comprehensive data base of chemicals identified in human biological media
(tissues and body fluids) has been established under the direction of the^Environmental
Protection Agency's Office of Pesticides and Toxic Substances Exposure Evaluation
(formally Survey and Analysis) Division. This centralized resource of body-burden
information was inspired by the concern of government scientists over continuing
reports of toxic chemicals in human tissues and body fluids.
Body burden is a reflection of exposures to food, air, and water contaminants,
as well as Pharmaceuticals. The systematic acquisition of body-burden data will
facilitate a more relevant assessment of human exposure to toxic chemicals and
xenobiotics than was previously possible using environmental contamination levels.
Data were obtained primarily from the open literature through manual searches
of selected journals. Retrospective searching to 1974 is complete and has yielded
over 3000 pertinent documents of which approximately 1000 have been entered into the
data base as of this report. These sources identify over 500 chemicals which have
been found in human biological media.
17.
KEY WORDS AND DOCUMENT ANALYSIS
DESCRIPTORS
b.IDENTIFIERS/OPEN ENDED TERMS
COS AT I Field/Group
Body-burden
Human tissues/body fluids'
Residues
18. DISTRIBUTION STATEMENT
RELEASE TO PUBLIC
19. SECURITY CLASS (This Report)
UNCLASSIFIED
21. NO. OF PAGES
1210
20. SECURITY CLASS (This page)
UNCLASSIFIED
22. PRICE
EPA Form 2220-1 (9-73)
-------
683
EPA 560/13-80-036B
ORNL/EIS-163/V2-P2
INTERNAL DISTRIBUTION
1. S. I. Auerbach 10. Biology Library
2. M. F. Baldauf 11-12. Central Research Library
3. M. V. Cone 13. Document Reference Section
4. J. T. Ensminger 14. ICC Publications Office, 2001
5. W. Fulkerson 15-24. ICC Resource Center, 2001
6. H. B. Gerstner 25-26. Laboratory Records
7. F. M. Martin 27. Laboratory Records, RC
8. C. R. Richmond 28. ORNL Patent Office
9. G. D. Robbins
EXTERNAL DISTRIBUTION
29. Philip L. Johnson, Executive Director, Oak Ridge Associated
Universities, P.O. Box 117, Oak Ridge, Tennessee 37830.
30. Office of Assistant Manager, Energy Research and Development,
Department of Energy, Oak Ridge Operations Office, Oak Ridge,
Tennessee.
31-57. Technical Information Center, Department of Energy, Oak Ridge,
Tennessee 37830.
ftU.S. GOVERNMENT PRINTING OFFICE: 1980-640-245/427
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