GUIDANCE FOR THE
REREGISTRATION OF PESTICIDE PRODUCTS
(REGISTRATION STANDARD)
CONTAINING
BENQMYL
AS THE ACTIVE INGREDIENT
CHEMICAL CODE: 099101
CAS: 17804-35-2
CASE NUMBER: GS-0119
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20460
540/0435
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TABLE OF CONTENTS
Page
INTRODUCTION 1
PART I. REGULATORY ASSESSMENT 3
A. Description of Chemical 3
B. Summary of Assessment ...... 5
C. Agency Assessment 9
D. Regulatory Position and Rationale 27
PART II. REQUIREMENTS FOR REGISTRATION 33
A. Criteria for Registration 33
B. Acceptable Ranges and Limits. 33
C. Required Labeling 34
D. Products Subject to this Standard 36
E. Requirement for Submission of
Generic Data. ... .__ ...38
F. Requirement for Submission of
Product-Specific Data 43
G. Requirement for Submission of
Revised Labeling 44
H. Instructions for Submission 45
APPENDICES
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TABLE OF APPENDICES
I. DATA APPENDICES
Guide to Tables
Table A
Table B
II. LABELING APPENDICES
40 CFR 162.10 Labeling Requirements
Physical/Chemical Hazards Labeling Statements
Storage Instructions
Pesticide Disposal Instructions
Container Disposal Instructions
III. USE INDEX APPENDIX ~
IV. BIBLIOGRAPHY APPENDICES
Guide to Bibliography
Bibliography
V. FORMS APPENDICES
EPA Form 8580-1 FIFRA S3(c)(2)(B) Summary Sheet
EPA Form 8580-6 Certification of Attempt to Enter Into
an Agreement with Other Registrants for
Development of Data
EPA Form 8580- Product Specific Data Report
(End-Use Products)
EPA Form 8580- Formulator's Exemption Statement
ii
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INTRODUCTION
The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA),
Section 3(g), directs the U.S. Environmental Protection Agency (EPA)
to reregister all pesticides as expeditlously as possible.
To carry out this task. EPA has established the Registration
Standards program, which reviews all pesticide products contain-
ing active ingredients first registered before January 1, 1977.
Pesticides are reviewed In use clusters which have been ranked to
give earliest review to pesticides used on food and feed crops.
The Registration Standards program involves a thorough review of
the scientific data base underlying pesticide registrations and
an identification of essential but missing studies which may not
have been required when the product was initially registered or
studies that are now considered Insufficient. EPA's reassessment
results in the development of a regulatory position, contained
in a Registration Standard, on__each pesticide and its uses. The
Agency may require the registrant to modify product labels to
provide additional precautionary statements, restrict the use of
the pesticide to certified applicators, provide reentry intervals,
modify uses or formulation types, specify certain packaging
limitations, or other requirements to assure that proper use of
the pesticide will not result In unreasonable adverse effects on
the environment.
The scientific review, which is not contained in the Registration
Standard, but is available from the National Technical Information
Service, concentrates on the technical grade of the active
ingredient and identifies missing generic data. However, during
the review of these data, the Agency is also looking for potential
hazards that may be associated with the end-use (formulated) pro-
ducts that contain the active Ingredient. If the Agency has
serious concerns, the end-use products (EPs) will be addressed as
part of the Registration Standards program and regulatory actions,
to the extent necessary to protect the public, .will be proposed.
This Registration Standard contains the results of the Agency's
review of all registered manufacturing-use products (MPs) contain-
ing benomyl as the sole active ingredient. During this review,
the Agency evaluated all MPs and Section 3 and 2Mc) uses
registered for benomyl.
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Part I, the Regulatory Assessment of this standard contains the
following: A. Description of benomyl, B. Summary of regulatory as-
sessment/ C. Summary of the Agency's assessment/ and D. Regulatory
position and rationale for benomyl.
Part II, the Requirements for Registration, addresses the following!
A. Criteria for registration, B. Acceptable ranges and limits/
C* Required labeling, D. Products subject to this Standard,
E. Requirements for submission of generic data, F. Requirements for
submission of product-specific data, G. requirements for submission
of revised labeling, and H. Instructions for submission.
Information on specific data requirements copies of appropriate
forms for submission of information to the Agency are included in
the appendices.
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PART I. REGULATORY ASSESSMENT
The Agency has conducted a thorough review of the scientific data
base on benomyl and reassessed its earlier regulatory position taken
on benomyl in 1982. This Part of the Standard sets forth the re-
sults of that review beginning with a description of the chemical
and its uses, followed by a discussion of the data base and the
resultant regulatory position.
A. DESCRIPTION OP CHEMICAL
1. Description
Common Name
Chemical Name
Empirical Formula
Trade Names
Chemical Abstracts
Service (CAS) No.
OPP (Shaughnessy) No.
2. Use Profile
Type of Pesticide
Pest Controlled
Registered Uses
Predominant Use
Method of Application
Mode of Activity
Formulations
Technical
End Use
Benomyl
Methyl l-(butylcarbaraoyl)-2-
benzimldazolecarbamate
Tersan 1991*
17804-35-2
099101
Systemic Fungicide
Pathogenic Fungi
Croplands, Greenhouses, Ornamentals,
Turf sites, Preplant dip, Transplants
Rice & Soybeans
Broadcast; Banded Around: Aerial:
Over the Top, Irrigation Systems
Inhibition of fungal growth
95 percent active ingredient
Wettable Powder; Flowable
Liquid, Oil Dlspersable
3. History. Benomyl was patented by E.I. du Pont de Nemours
and Co., Inc. (U.S. Patent Nos. 3.541,2*13 and 3,631,176)
in 1968 and was first registered for use in 1969. Technical
benomyl is being produced in the United States by E.I. du
Pont de Nemours and Co., Inc., of Wilmington, Delaware.
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On December 6, 1977. the Environmental Protection Agency
initiated a Special Review [previously referred to as the
Rebuttable Presumption Against Registration (RPAR) Process]
for benomyl because of its rautagenic, teratogenie, reduced
spermatotoxic, and acute aquatic effects. 42 Fed. Reg.
61970. In addition, the Agency concluded that the use of
benomyl according to current label directions could result
in significant reductions in local populations of earthworms.
This Special Review was supported by a Position Document 1
(PD 1).
In the Preliminary Determination concluding the Special Review,
the Agency reaffirmed Its risk concerns, except for its concern
about the potential local population reduction of earthworms.
MM Fed. Reg. 51166 (August 30, 1979). The support document
for this preliminary determination was the Position Document
2/3 (PD 2/3).
Prior to the publication of the final benomyl regulatory
decision, new studies were—received by the Agency, indicating
that benomyl and its major metabolite, methyl-2-benzimldazole
carbamate (MBC) were carcinogenic. The Agency Issued its
final regulatory decision on benomyl on October 20, 1982,
M7 Fed. Reg. M67M7. In this Notice and the position document
supporting the decision (Position Document M), the Agency
determined that the potential oncogenic, mutagenic, teratogenic,
and spermatotoxic risks of benomyl would be exceeded by the
benefits associated with the use of benomyl products when
a dust mask was used by applicators during mixing and loading
of benomyl for aerial application. The Agency also determined
that a monitoring study of benorayl residues in rice field
water treated with benomyl must be submitted. This registration
standard reassesses the decisions announced in the final
determination of the Special Review.
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B. SUMMARY OF ASSESSMENT.
The Agency has reviewed all data submitted to support the regis-
tration of Benomyl. This Includes data on benomylfs primary
metabolite: methyl-2-benzimidazole carbamate (MBC). Based on
the review of these data, the Agency has determined the follow-
ing: (See Section C of this Part for more detailed Information).
1. Benomyl poses a limited oncogenic risk from dietary exposure.
The pesticide was classified as a Group C oncogen, which Is
defined as a possible human oncogen, based on the following:
(a) Benomyl and MBC have been shown to cause tumors solely
in the mouse liver.
(b) The liver tumors produced by benomyl and MBC were obser-
ved in two related strains of mice (CD-I and SPP Swiss),
whereas no liver tumors were produced by MBC in another
strain of mice (NMRKf SPP-71).
(c) Neither benomyl nor__MBC are oncogenic In ChR-CD rats.
(d) Benomyl and MBC produced weak mutagenic effects consis-
tent with spindle poison activity rather than gene muta-
tion or DNA repair activity.
2. Benomyl has been shown to cause teratogenic effects in rats
(microphthalmia) and mice (cleft palate, supernumerary ribs,
subnormal vertebral centrum). The No-Observed-Effect-Level
(NOEL) for rats was 30 mg/kg/day. The NOEL for mice was
50 mg/kg/day.
3. In a 3 generation study on male and female rats, the admi-
nistration of benomyl resulted in decreased pup weanling
weights at 500 ppm (25 mg/kg/day) and above.
M. Benorayl produced testicular effects (decreased size of testes
and depressed spermatogenesis) in test animals.
5. Benomyl and MBC are extremely toxic to freshwater fish and
aquatic Invertebrates.
6. Mixer/loader risk can be reduced to acceptable limits through
the use of a dust mask for aerial application.
7. Benorayl has significant benefits that are not outweighed
by the Identified risks:
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(a) Benomyl is a broad spectrum fungicide that controls a
wide variety of plant diseases in field and vegetable
crops, rice, tree fruit and nut crops, greenhouse,
ornamentals, and turf sites. It is also used as a
postharvest dip for fruits.
(b) Due to Benomyl's systemic properties and broad activity
spectrum, the number of preharvest treatments needed for
crop disease control are greatly reduced. Benomyl is
particularly efficaceous against plant diseases during
seasons of average to heavy rainfall when conditions
conducive to disease development exist.
(c) Benomyl is applied aerially, by ground equipment, with
liquid fertilizers, and over-the-top in tank mixes.
Benomyl is also widely tank mixed with non-benzimidazole
fungicides to prevent the emergence of benomyl-resistant
plant pathogens.
(d) Benomyl and certain benzimidazole fungicides provide
rice growers with effective control agents against
foliar and head diseases of rice.
The Agency has identified missing data necessary to evaluate
the environmental.and human risks associated with the use of
benomyl. These data must be developed in order to maintain
registrations of products or register new products containing
benomyl. The table in this section summarizes the data gaps,
in addition to product chemistry information. Please note
that this is only a summary and more details can be obtained
by referring to Table A, Appendix I.
The Agency has also determined that label revisions must be made
in the following areas (See Part II, Section C.):
0 Environmental Hazards
0 Grazing Restrictions
0 Protective Clothing
0 Rotational Crop Restrictions
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SUMMARY OP DATA GAPS - BENOMYL
(Refer to Table A, Section D, Part II,
for details regarding specific requirements)
DATA REQUIREMENT REMARKS
158.120 Product Chemistry:
61-2 Description of Beginning Materials
and Manufacturing Process
62-2 Certification of Limits
63-9 Vapor Pressure
63-12 pH
158.125 Residue Chemistry:
171-1 Nature of Residue (Plant & Animal Metabolism)
171-1 Residue Analytical Methods
171-1 Residue Studies In Cattle, Goats, Hogs, Horses,
Sheep, Milk, Poultry and Eggs.
171-1 Residue Studies on Crops, Processed Food/Peed
Commodities
158.135 Toxicology:
82-1 90-Day Inhalation (Rat)
85-1 General Metabolism
158.130 Environmental Fate:
162-1/1 Metabolism Studies
163-1/3 Mobility Studies/Ground Water Assessment
161-1,2.5 Dissipation Studies
165-1/1 Accumulation Studies
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SUMMARY OP DATA GAPS - BENOMYL (Continued)
(Refer to Table A, Section D, Part II,
for details regarding specific requirements)
DATA REQUIREMENT REMARKS
158.115 Wildlife & Aquatic Organisms
71-1 Acute Avian Oral Toxlclty
71-2 Sub acute Avian Oral ToxicIty (Waterfowl)
70-1 Special Testing (Residue Monitoring)
72-1 Freshwater Pish Toxlclty (Warmwater Species)
72-2 Acute Toxlclty to Freshwater Invertebrates
72-3 Acute Toxlclty to Estuarlne & Marine
Organisms
72-1 Fish Rarly Life Stage & Aquatic
Invertebrate Life-Cycle
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C. AGENCY ASSESSMENT.
The Agency has conducted a thorough review of the scientific
data base for benomyl. The following is a discussion of the
results of the review.
1. Preliminary Risk and Benefit Analysis
a. Risks. To assess the risks associated with benomyl, the
Agency reviewed the existing data base. This Included the
review of studies conducted for oncogenicity, mutagenicity,
reproductive effects, teratogenlclty and metabolism.
Based on these studies and available exposure information,
the dietary risk and applicator exposure and risk have
been calculated. The following is a discussion of the
results of the risk assessment.
(1) Oncoge_nleity Studies;
a) Mouse Oncogenicity Study of Benomyl
Haskell Laboratory adjninlstered Benomyl in the diet to
groups of 80 male and 80 female CD-I mice at concentra-
tions' of 0, 500, 1500 or 7500/5000 ppra for 2 years. The
high dose of 7500 ppm was reduced to 5000 ppm at 37 weeks
in males and females due to weight loss. There were no
significant differences in survival rates In either males
or females. The following Incidence patterns of tumors
are suggestive of a compound-related effect.
Organ & Tumor
Type
Sex (ppm) 0
500
1500
7500/5000
(Mg7kg/day)
0 25
75
375/250
Lung:
Alveologenlc M 13/79(16%) 24/79(30%)*
carcinoma P 16/77(21%) 7/79(9%)
Liver:
Adenoma
Carcinoma
Combined
Adenoma
Carcinoma
Combined
M 9/77(12%)
M 16/77(21%)
M 25/77(32%)
P 2/77(2.5%)
P 2/77(2.5%)
P V77(5%)
9/80(11%)
26/80(32%)«
35/80(44%)*
2/80(2%)
7/80(9%)»
9/80(11%)
23/79(29%)»
4/78(5%)
11/79(14%)
41/79(52%)*
52/79(66%)*
7/79(9%)
6/79(7%)
13/79(16%)*
16/80(20%)
6/74(8%)
10/80(12%)
17/80(21%)
27/80(34%)
7/77(9%)
14/77(18%)*
21/77(27%)*
*= p<0.05 compared to controls
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Pulmonary carcinomas were significantly elevated in male
mice (low and mid doses). The effect did not appear to
be compound related for the following reasons: 1) A dose-
response effect was not observed in the Cochran-Armitage
test for trend. 2) Low tumor incidences in high doses could
not be attributed to early death. 3) All tumor incidences
were within the range of historical controls (16% to 36%).
The mean +_ S.D. for pulmonary tumors for seven studies, not
including benomyl, conducted at Haskell Labs for the two
years preceding and subsequent to the benomyl study was
24+17 % (total of 564 animals). 4) The tumor incidence in
the benomyl control group was equal to the lowest incidence
level observed in the historical control group. 5) Pulmo-
nary tumor incidences in the low and mid dose groups are
not statistically different from the historic controls
and only marginally significant (p * .05) from the concurrent
controls. 6) In addition, nearly all benomyl administered
is rapidly converted to MBC and MBC did not produce an
increase in pulmonary tumors in other studies performed
in CD-I mice. Therefore these tumors are not considered
to be biologically significant or compound related.
Hepatocellular carcinomas were significantly elevated in
male (low and mid doses) and female (low and high doses)
mice. In addition, adenomas and carcinomas combined were
significantly elevated in males (low and mid doses) and
females (mid and high doses). The tumorigenic responses
appeared to be compound related; e.g., they occurred with
significant positive trends, and the elevated incidences
exceeded historical rates for these tumor responses in two
other studies conducted at the registrant's laboratory.
Furthermore, similar liver tumorigenic responses were
produced by the MBC metabolite in other studies performed
in CD-I mice (see below). The oncogenic responses that
were produced by benomyl in treated mice were not accom-
panied by increased incidences of hepatocellular adenomas
or hyperplasia.
The highest dose of benomyl tested in male mice in this
study probably exceeded a maximum tolerated dose (MTD)
level. This dose in males produced a decreased weight
gain (approximately -9%), heptocellular toxicity (e.g.,
foci of cellular alteration, cytomegaly, and foci of
degeneration), and degenerative changes in the testes
(e.g., atrophy, seminiferous tubule degeneration, and
interstitial cell hyperplasia) and in the epididymis
(aspermia). This dose did not produce liver tumors in
males, possibly because of the hepatocellular toxic
changes that were observed (e.g., the observed liver
toxicity may have altered the ability of benomyl to be
metabolized to MBC). The low and mid dose levels of
benomyl did produce liver tumors in males, but these
doses were not associated with any other toxic effects
and thus did not approximate a MTD level.
10
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The highest dose of benorayl tested In females probably ap-
proximated a MTD level as evidenced by findings of decreased
weight gain (approximately -9%), elevated liver weights,
reduced kidney weight, and spleen hemosiderosis. This dose
in females did produce liver tumors, as did lower doses
of the compound. Benomyl did not produce the exaggerated
liver toxic changes in female mice that were observed in
male mice.
b) Mouse Oncogeniclty Study of MBC
Haskell Laboratory administered MBC In the diet to groups
of 80 male and 80 female CD-I mice at concentrations of
0, 500, 1500, 7500 (females) or 7500/3750 (males) ppm for
2 years. The high dose of 7500 ppm was reduced to 3750
ppm at 66 weeks in males due to increased mortality, and
all males were ultimately sacrificed at 73 weeks. The
following incidence pattern of liver tumors was observed.
Liver Tumor
Type
Adenoma
Carcinoma
Combined
Dose
Sex (ppm) 0 500
(Mg/kg/dajL)
0 25
M 11/80(14%) 15/80(19%)
M 2/80(2%) 5/80(6%)
M 13/80(16%) 20/80(25%)
1500
75
14/80(17%)
9/80(11%)*
23/80(28%)*
7500/#
375
3/80(4%)
0/80(0%)
3/80(4%)
Adenoma P
Carcinoma P
Hepatoblastoraa P
Total P
0/79(0%)
1/79(1%)
0/79(0%)
1/79(1%)
5/78(6%)*
4/78(5%)
0/78(0%)
5/80(6%)*
15/80(18%)*
1/80(1%)
21/80(26%)*
3/78(4%)
12/78(15%)*
0/79(0%)
15/78(19%)*
*= p<0.05 compared to controls
#= Reduced to 3.750 ppm (188 mg/kg/day) in males at 66 weeks.
11
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Hepatocellular carcinomas, and adenomas and carcinomas
combined, were significantly elevated in male mice (mid
dose level); no increase in adenomas occurred in males.
The lack of oncogenlc response In high dose males is
likely to be explained by their early deaths and sacrifice
at 73 weeks. In female mice there were significant in-
creases in adenomas (low and mid doses), carcinomas (raid
and high doses), and adenomas and carcinomas (all 3 dose
levels tested). The Toxicology Peer Review Committee
(TPRC) of the Office of Pesticide Programs noted that
this profile of liver tumors resembled that described
above for benorayl in CD-I mice. No increased incidence of
liver hyperplasia occurred in treated mice. A comparison
of the MBC liver tumor data with historical control data
from two other studies conducted at Haskell Laboratory
(the "unnamed" study and the benorayl mouse study in CD-I
mice; see Copley/Harris memorandum of 12/19/85, page 10)
Indicated that only the carcinomas (mid and high dose
levels) and the adenomas/carcinomas combined (all 3 dose
levels tested) in female mice exceeded the control response
rates in the other studies.
The high dose level oT MBC tested in male mice clearly
exceeded a MTD level because of excess mortality.
The mid dose level appeared to approximate a MTD level.
Both these doses in males caused reduced weight gain,
hepatocellular toxiclty (e.g., plgmented macrophages,
hypertrophy, and centrilobular necrosis), renal tubular
pigmentation, thymic lymphold depletion, and sperm stasis.
The changes however were more severe at the high dose
level.
The highest dose of benomyl tested in females appeared to
approach but did not exceed the MTD level. This dose
caused increased liver weight and foci of eosinophilic
hepatocellular alteration, renal tubular pigmentation,
and thymic lymphoid depletion.
c) Mouse Oncogenicity Study of Carbendazlm (99% MBC):
In a study performed by the Central Institute for Nutrition
and Pood Research (TNO), and reviewed in summary form by
the World Health Organization (WHO) (see Copley/Harris
memorandum of 12/19/85. page 7)» MBC was administered In
the diet to groups of 100 male and 100 female SPP Swiss
mice at concentrations of 0, 150, 300 or 1000/5000 ppm
for 80 weeks. The 1000 ppm concentration was increased
to 5000 ppm in males and females at week 8. Data were
presented in summary form only. The following incidence
pattern of liver tumors was observed.
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Liver Tumor
Type
Sex (ppm) 0
(mg/kg/day)
0
Dose
150
22.5
300
45
1000/5000
150/750
Neoplastic Nodule M
Carcinoma M
Hepatoblastoma M
Total M
Neoplastic Nodule P
Carcinoma F
Hepatoblastoma P
Total P
9/100(9*)
1/100(1*)
0/100(0*)
10/100(10%)
0/97(0*)
1/97(1*)
0/97(0*)
1/97(1*)
7/98(7*)
1/98(1*)
1/98(1*)
8/98(8*)
1/99(1*)
0/99(0*)
0/99(0*)
1/99(1*)
14/100(14*)
9/100(2*)
1/100(1*)
16/100(16*)
1/98(1*)
0/98(0*)
0/98(0*)
1/98(1*)
16/100(16*)
3/100(3*)
7/100(7*)«
17/100(17*)
9/97(9*)«
0/97(0*)
0/97(0*)
9/97(9*)
»« P<0.01 compared to controls, Exact test.
Hepatoblastomas (a less common and malignant liver tumor
than hepatocellular carcinoma) were significantly elevated
in male mice (high dose level), and neoplastlc nodules
(i.e., adenomas) were significantly elevated in female
mice (high dose level). The TPRC noted that the SPP Swiss
strain of mouse used in this study is genetically similar
to the CD-I strain ofmouse in which benomyl and MBC were
tested. The CD-I strain is an outbred strain of the SPP
Swiss mouse. Both strains tend to exibit a high background
incidence of liver adenomas in male mice.
Based on the summary information available for this study.
the highest dose level of MBC tested did not appear to
exceed a MTD level. The HOT caused increased relative
liver weights and clear cell and/or mixed hepatic cell
foci in males and females.
d) Mouse Oncogenicity Study of Carbendazlm (MBC)
In another study reviewed by the WHO (see Copley/Harris
memorandum of 12/19/85, page 8), MBC was administered in
the diet to groups of 100 male and 100 female HOE NMRKf
(SPP 7D mice at concentrations of 0, 50, 150, 300 or
1000/5000 ppra (0, 7.5, 22.5, *5 or 150/750 mg/kg/day) for
22 months. The 1000 ppra concentration was increased to
5000 ppm at .week 8. No evidence of an oncogenlc response
in the liver or at any other site was observed. The TPRC
noted that the NMRKf strain of mouse, in contrast to CD-I
and SPP Swiss mice, normally exhibits a low background
incidence of liver tumors.
The highest dose of MBC tested in this study appeared to
be close to a MTD level as indicated by findings of liver
toxiclty in both male and female mice (e.g., liver cell
hypertrophy, clear cell foci, liver cells in mitosis, pig-
mented Kupffer cells, enlarged cell nuclei, and multiple
cell necrosis).
13
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e) Rat Oncogeniclty Studies of Benomyl and MBC
Benomyl was studied in a 2-year dietary study (0, 100, 500
or 2500 ppm) (0, 5, 25, 125 mg/kg/day) in ChR-CD rats: the
highest concentration was a systemic NOEL and no oncogenic
effects occurred. A maximum tolerated dose (MTD) was not
established for benomyl.
MBC was also studied in a 2 year dietary study (0, 100,
500, 2500/10,000 or 5000 ppm) (0, 5, 25, 125/500 or 250
mg/kg/day) in ChR-CD rats; no oncogenic effects occurred.
The MTD was established at the highest dose demonstrated
by weight loss in males and females (10/C-20/C less than
controls) and hepatic pericholangitls. Both of the above
studies were performed by Haskell Laboratory.
(2) Additional Toxicology Data on Benomyl and MBC:
a) Metabolism
Limited studies conducted in mice indicate that benomyl is
primarily metabolized to MBC, which in turn is converted
to 2-amlnobenzaraidole (2-AB) and also to 5-OHMBC and
5-OH-2-AB. The latte~r 2 metabolites undergo sulfate and
glucuronide conjugation. Elimination of metabolites
occurs rapidly in urine and feces (e.g., 94% of an orally
administered radlolabeled dose was excreted in 96 hours in
mice as the metabolites, with no parent compound detected).
No unusual localization of benomyl or its metabolites has
been found In animal tissues.
b) Teratology
Benomyl has been demonstrated to be teratogenic in several
oral (gavage) studies conducted in both Wistar and ChR-CD
rats at a dose of 62.5 mg/kg/day and higher. The most
common abnormality in these studies was microphthalmla.
In most of these studies, fetotoxic and erabryotoxic effects
were also observed at similar or greater dose levels.
Benomyl was also reported to be teratogenic in one study
in CD-I mice at oral (gavage) doses of 100 mg/kg or more.
In the first study, benomyl was administered by gavage to
- 27 ChR-CD strain rats at each of the following doses:
0, 3, 10, 30, 62.5. and 125 mg/kg/day for days 7 through 16
of gestation. Dams were sacrificed on day 21 of gestation
and the fetuses examined. There were no treatment related
maternal or fetal toxic effects except for decreased fetal
weight in the 62.5 and 125 rag/kg/day groups. There were
significant Increases in microphthalmla and anophthalmia
at 62.5 and 125 mg/kg/day and distended lateral ventricles
and hydrocephaly at 125 mg/kg/day. Two cases of microph-
thalmla also occured at 10 mg/kg/day. The NOEL for maternal
toxicity was greater than 125 mg/kg/day and the fetal
toxic NOEL was 30 mg/kg/day.
14
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The second rat study involved the administration of benomyl
by gavage to 46-48 Crl:CD® (SD)BR rats at each of the
following doses: 0.3, 6.25, 10, 20, 30 and 62.5 (only 19
dams) mg/kg/day for days 7 through 16 of gestation. Dams
were sacrificed on day 21 of gestation and the fetuses
examined specifically for ocular effects. There were no
treatment related signs of maternal toxicity noted. The
high dose fetuses were significantly lighter than the
controls. There was 1 fetus with microphthalmia present
in the 16 litters in the high dose; no other ocular ab-
normalities were reported.
When considered together, these two rat studies give a
NOEL of 30 mg/kg/day and a LEL of 62.5 mg/kg/day for
teratogenic effects. The Wistar rat study gave similar
results.
Benomyl technical was also administered by gavage to 25
pregnant CD-I mice at each of the following doses: 0, 50,
100, and 200 mg/kg/day for days 7 through 17 of gestation.
Dams were sacrificed on day 18 of gestation and the fetuses
were examined. Doses as high as 200 mg/kg/day did not
affect maternal viability or growth. Doses of 200 (signi-
ficant from controls p < 0.05) and, to a much lesser extent,
100 mg/kg/day, adverseTy affected fetal development indu-
ing: decreased fetal weight, and delayed skeletal and
visceral (including subnormal vertebral centrums, enlarged
cerebral ventricles, and renal pelves) development, and
increased supernumerary ribs. The incidence of major
anomalies observed in the fetuses was 1.3, 1.0, 16.8, and
47.3% at 0, 50, 100, and 200 mg/kg/day. The incidences
of major fetal and litter anomalies were significant at
the p <0.001 in the mid and high dose groups. Anomalies
included: short and/or kinky tail, fused vertebrae, fused
ribs and cleft palate. The NOEL was 50 mg/kg/day and a
LEL, based on teratogenic effects, was 100 mg/kg/day.
c) Reproductive Effects
In a 3 generation study on male and female rats, benomyl
was administered in the diet at 0, 100, 500, and 2500 ppm
(0, 5, 25, 125 mg/kg/day) to male and female ChR-CD rats
evoking decreased pup weanling weights at 500 ppm and
above. The NOEL was 100 ppm (5 mg/kg/day) and the LEL,
based on decreased pup weanling weights, was 500 ppm
(25 mg/kg/day).
15
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d) Mutaqenicity
Data provided in the Position Document 4 on Benomyl and
MBC indicated that both compounds are spindle poisons
often associated with aneuploidy and nondisjunction. For
example, nondisjunction was reported in A. nidulans with
both agents. The compounds also produced* positive effects
in tests to assess structural chromosome aberrations which
were consistent with a spindle effect; e.g., benomyl was
weakly positive for sister chromatid exchange in vitro in
Chinese hamster ovary cells with and without activation,
and both benomyl and NBC caused increased incidences of
micronuclei in polychromatic erythrocytes in mice bone
marrow. In other studies performed to assess gene muta-
tions equivocal results were obtained. That is, MBC was
weakly positive in one mouse lymphoma test (L5178Y TK+/~)
but was negative in a second test/ Benomyl and MBC produced
both positive and negative results in different Ames tests,
and both compounds produced negative results in Chinese
hamster ovary cells (HGPRT). Finally, negative results
were obtained for DNA repair with Benomyl and MBC in se-
veral studies in primary mouse and rat hepatocyte cultures.
The TPRC concluded that these results/ when taken together/
indicated that both Benomyl and MBC have weak mutagenic
activity that is primarily attributable to adverse effects
on the cellular spindle apparatus. This pattern correlates
well with teratogenic and spermatotoxic effects also
observed with other benzimidazole compounds. Correlation,
or the lack there of/ with oncogenicity has not been
demonstrated conclusively.
e) Structure-Activity Correlations
Both Benomyl and MBC bear a close structural resemblance
to several other benzimidazole compounds that are suspect
oncogens (e.g., fenbendazole and albendazole). The poten-
tial oncogenic effects of these compounds are currently
under review by the Center for Veterinary Medicine/ Food
and Drug Administration and were recently discussed in a
Congressional Subcommittee Hearing (reference: Human Food
Safety and the Regulation of Animal Drugs; 27th Report by
the Committee on Government Operations, December 31, 1985.
Union Calendar/ No. 274. Intergovernmental Relations and
Human Resources Subcommittee. Ted Weiss, New York/ Chair-
man; pp. 1-115). In the case of fenbendazole/ a high
incidence of liver nodular hyperplasia and low incidences
of liver neoplastic nodules/ adenomas and carcinomas were
observed in rats. In the case of albendazole/ histiocytic
sarcomas were observed in rats and uterine polyps were
observed in rats and mice. The TPRC was aware that final
decisions regarding the classification of these chemicals
as oncogens had not yet been made by the FDA.
16
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{3) Risk Assessment;
The Agency has reviewed oncogenicity studies for benomyl
and its metabolite MBC, and concluded that these data
provide limited evidence of oncogenicity for these chemicals
in male and female mice* According to EPA Proposed
Guidelines for Carcinogen Risk Assessment (November 23,
1984, 49 PR 46294), benomyl has been classified as a
Group C oncogen, that is, possibly a human oncogen.
The Toxicology Peer Review Committee (TPRC) chose to clas-
sify benomyl and MBC in Group C (limited evidence of
carcinogenicity) for the following reasons:
a) The oncogenic responses observed with benomyl and its
metabolite MBC were confined solely to the mouse liver.
b) Neither beaaorayl nor MBC were oncogenic in ChR-CD rats.
c) Although oncogenic responses were seen in more than
one study, each study had similar dosing ranges and the
test chemicals were administered in the feed. Further-
more, the liver tumors produced by benomyl and MBC
were observed in two genetically related strains of
mice (CD-I and SPF Swiss), whereas no liver tumors were
produced by MBC in a genetically unrelated strain of
mouse IHOE NMRKf (SPF-71)].
d) Benomyl and MBC produced weak mutagenic effects consis-
tent with spindle poison activity rather than gene
mutation or DNA repair activity. The TPRC noted
that this pattern of mutagenic activity correlates
well with teratogenic and spermatotoxic effects.
Correlation, or lack there of, with oncogenicty has
not been demonstrated.
The TPRC concluded that the data available for benomyl and
its primary metabolite MBC, provide limited evidence of
oncogenicity for both chemicals in male and female mice.
Criteria contained in the proposed EPA Guidelines (CFR,
November 23, 1984) for classifying a carcinogen in either
Category 82 or C were considered. Benomyl and MBC met
some of the critieria specified for the 62 classification.
That is, both benomyl and MBC produced an increased incidence
of malignant or combined malignant and benign tumors in
genetically related strains of mice (CD-I and SPF Swiss) and
in multiple experiments. Furthermore, MBC did produce an
unusual type of liver tumor (hepatoblastoma) but only in male
SPF Swiss nice.
17
-------
Despite these considerations, the Toxicology Peer Review
Committee decreased the classification to Group C
(limited evidence of carcinogenicity) for the following
reasons: (1) Neither benomyl nor MBC produced tumors in
the rat. (2) The oncogenic responses observed with benomyl
and MBC were confined solely to the mouse liver in 2
genetically related strains of mice (CD-I and SPF Swiss).
(3) No liver tumors were produced by MBC in a genetically
different strain of mouse [HOE NMRKf (SPF-71)]. (4) The
genetic toxicity of benomyl and MBC is minimal, that is,
they produced weak mutagenic effects consistent with
spindle poison activity rather than gene mutation or DNA
repair activity. Because of these factors, the Committee
determined that there was insufficient evidence for the 82
category and therefore, in conformity with the EPA Guide-
lines noted above, classified both benomyl and its primary
metabolite, MBC, as Group C (possible human) carcinogens.
(4) Dietary Risk;
a) Teratogenesis
The NOEL for terato_g,enic effects is 30 mg/kg/day based
on microphthalmia in the Charles River rat. The distri-
bution of exposure for the population at risk (females
greater than 13 years of age) was obtained using the
Agency's Tolerance Assessment System (TAS) [Saunders
et al., 1986] based on the assumption that residues
are present at tolerance levels. The weighted-average
daily exposure, which represents exposure for 50% of
the individuals at risk, is 0.04 mg/kg/day. This
results in a margin of safety (MOS) of approximately
750. Forty-four percent of the women in this risk
category had a MOS greater than 1,000. Three percent
had a MOS of 200. The remaining fifty-three percent
had a MOS which ranged from 200 to 1,000.
b) Spermatotoxic Effects
The NOEL of 62.5 mg/kg/day for spermatogenic effects
from the chronic dog feeding study was used for dietary
risk. Using the detailed acute analysis of TAS and as-
suming residues for every commodity are present at tole-
rance levels, a weighted-average daily exposure of 0.035
mg/kg/day was obtained. This results in a MOS of
approximately 1,800 for males.
18
-------
The distribution of exposure for the population at risk
(males greater than 13 years of age) was obtained using
the TAS analysis. No individuals had exposures greater
than 0.225 mg/kg/day. The MOS was approximately 280 for
the individual with the highest exposure.
c) Oncogenic Effects
In the PD-4, the Agency performed a quantitative onco-
genic risk assessment for benomyl. That assessment
was based on a body weight to body weight species
conversion. Present Agency guidelines call for a
surface weight species correction unless a biological
reason for using a different conversion exists. There-
fore, an updated risk assessment was performed. The
Agency will request comments from the Scientific Advi-
sory Panel (SAP) on the weight the Agency should place
on a quantitative risk assessment for benomyl.
The 95% upper confidence level potency estimator, Qi*r
for oncogenicity is 3.9 x 10~3 (mg/kg/day)~1. The expo-
sure which results from the TMRC is 0.0337 mg/kg/day.
When a correction is made for the percent of the crop
treated, the exposure would be 0.0074 mg/kg/day. The
TMRC is based on tolerance levels and provides a
conservative estimate, moreover, when actual residue
data are available the risks may be several orders of
magnitude lower. The resultant risk would be 10~^(C)
(uncorrected) and lO^tC) (corrected for percent of
crop treated) respectively. This risk is the same
order of magnitude as the risk calculated in the PD-4.
(5) Applicator Exposure and Risk;
Dermal exposure to benomyl is minimal because its ab-
sorption is not significant. Percent of benomyl ab-
sorbed/unit time decreases with increasing dose in a
non-linear fashion. Absorption increased with the
duration of exposure to a maximum at about four hours.
This is based on a study (GS0119-014) in which four
rats/time point/dose were treated dermally (greater
than 16% of their surface area) with Benlate® (50%
a.i.). The durations of exposure were 0.5, 1, 2, 4,
and 10 hours; doses tested were 0.2, 2, 20, and 200 mg
of !4C-Benlate/rat (0.1, 1, 10, and 100 rag, respectively
of benomyl). The concentration of benomyl in the
blood increased (nonlinear) with increasing dose. The
percent of administered dose of benomyl in the urine
19
-------
decreased (nonlinear) with increasing dose and increased
(nonlinear) with duration. The percent absorption
also had a nonlinear decrease with increasing dose and
a nonlinear Increase with duration. The percent absor-
bed ranged from 0.031 (high dose) to 3.518 (low dose)
for the maximum exposure of 10 hours. By 10 hours,
96 to 99 percent of the absorbed dose at all treatment
levels had been excreted In the urine.
For mixing, loading and application, it was concluded
that the worst case (maximum) dermal exposure would
not result in dermal absorption of more than 0.006
ng/kg/day.
Inhalation exposure is the primary route of applicator
exposure to benomyl. The worst case Job related exposure
would be for mixer/loaders for grapes/fruit crops with
aerial application (i.e. 0.35 mg/kg/day without a dust
mask). This exposure would result In a MOS of 21 for
spermatogenic inhibition and a MOS of 90 for teratogenlc
effects. The exposure would decrease by 90% when the
mixer/loader wears a dust mask, thus increasing the MOS
to 210 and 900.
The oncogenic risk to mixer/loaders Involved in aerial
application without respiratory protection ranges from
less than 10~6 (c) to 10''* - 10~5 (C). If a dust mask
is used, the risk ranges from 10~6 (C) to 10~5 (C).
b. Benefits. An assessment of the benefits of benomyl was
performed In 1982 in connection with the Special Review of
benomyl. That assessment examined the use patterns of the
chemical and the available alternatives. Data submitted
since 1982 confirmed the basic conclusions of the 1982 as-
sessment. The following is a result of the 1982 assessment.
Benomyl is a broad spectrum fungicide that controls a wide
variety of plant diseases in field and vegetable crops, rice,
tree fruit and nut crops, greenhouse, ornamentals, and turf
sites. It Is also used as a postharvest dip for fruits.
Senorayl Is applied aerially, by ground equipment, with li-
quid fertilizers, and over-the-top in tank mixes. Benomyl
Is also widely tank mixed with non-benzlmidazole fungicides
to prevent the emergence of benomyl-reslstant plant
pathogens.
20
-------
Alternative pesticides are registered for most of the crops
on which benomyl is used. Generally these alternatives are
also considered effective. However, benomyl is more effi-
cacious against plant diseases than alternatives during
seasons of average to heavy rainfall when other conditions
that are conducive to disease development exist. Due to
benomyl's systemic properties and broad activity spectrum,
the number of preharvest treatments needed for crop disease
control are also greatly reduced.
Benomyl and certain benzimidazole fungicides have provided
rice growers with effective control agents against foliar
and head diseases of rice.
Refer to Tables A, B, and C, below for the list of economic
data and alternatives for benomyl.
For a more detailed benefit analysis on benomyl, refer to
Section III, "Qualitative Benefits Analysis" in the PD-4:
HH to 50.
21
-------
Table A
of the EoonoMlc lajnrtanc* of Rwueyl
B»tant of U» Quantity Banoayl Applied
Sit* Unit* TreatedToTu.ll. |Uba. Active Inarwllent)
Availability of
Boanoelc Alternatives
liejMCt
fnilts and HUM
Apples, riehei»eat 90,000-iM.noQ it-n
19,000-101.900
Captan, dlchlam, dadlm,
•ulphur, captufol, dlnocap
awmb * dlnaotp
•ostharvest l.0> Billion taw 90
citrue,
Grapefnitt
Other
1*0,000
35.000
100,000
f.t billion ID*.
30
II
10,000
IW,000
92.MO
0,900
•r-
4.000
Or,
100,000-119,000 12-14
7ft .000-1 lO.
Oil, aappara, captafol
Tin la Uw najor altwr-
natlwai mr » dlphmyl
oftan uaad on ••portad
Cnilt.
Cnptan, Colpnt, avwub,
ooppera. dlcloran
10,710 ton.
15% of
fr«ati
crop In
HA I** Available}
Optan and f*V» for
fnMh fnillai captan
and captafnl for
planting atodi
of ».!-.* •Illlon
pmr yaar In dry y«are.
SI.4-2.7 ail 11 Ion In wat
yaara plua protoction
loaaaa (tl.0-1.0 Million
for every 1% lonal. Hlnnr
»r lapacta.
SlfM.OOO/year plua loaaea
dua to Increased atorAge
rot (U.JS •! 11 Inn for
1% Inaal.
91.4 •Illlon total cltruai
anatly fruit downgrading
and IncrnaMd ahlpplng
loaaaa of grapefruit for
tha Japamaa a«rkat.
SMM.OOO pur yaar but In-
craaaad loaaaa dti« to
decay In ahlpptng «nrt
awrketlng. Owviy toaa un-
known but aach 1% losa •
$4.ft •Illlon. STPW rnlilI
price IncriAaea anrl hraw>
fruit decay prahlem.
«l.4-1.« •Illlon par y^ar
plua production loaaaa,
especially In wnt grwlng
anaaona. Pmrtuctlon loa-
aea would lncr4AM» the
retail priced for grapca
and ralalna.
•1.92 •!!! Inn losa In pro-
duction. 2.11 nrfectlrai
In HI crop, further Inaa
of 1% of frmih mipply.
Rntall prlue ImtraAma for
fraah «nrl cannMl fruit.
(\
c\
-------
Table B
nit*
extent ot Oaa Quantity Bencawl Applied
i. Active Ingredient)
Units Tcealefl l of U.B. (Lba.
Availability of
KoonoMlc Alternative!
Kcronmlr
Stone Fnilts
Peaches 190,000-200,000 acre* 90-79
Nectarlnea 9,200-13,600 acre* 90-73
Pontharveat
112,900-187,900
7,400-II,COO
Alamda
Avocado*
Mnanaa
Her rlea
110
Hacanawla nutu
3,200 acre*
HO
90 (PL)
Peara
Pecans
100,000 acre*
100 - 2,400
ft,000
10.920
100,000
Captan, nulphiir, Mtiwn
captafol, rtndlne
DlchlorMi
NA
9 (PL)
In US
Kaat 90
Neat 50
Raspberries
Rast 10-*0
Neat 9O-RO
w.eoo
1,«00
«M| firm
afHUfUIPU
(Central Jvaitle
71,911
NA
Copper (poor alternative)
Nanoocab, aMneb
a) thlophanata avthyl
Perham, captan. Urn
sulphur, dlnocap
CTff YFARS MTT YKAHS
Jin Ml 11 Inn* ofTKTKrST
1.19-ft.S? 11.11-19.07
O.J-0.4S I.2H-1.M
In
Prorlurtlon
aemnn wnuM
retail prlcea
Not quAntlH*1. Current
laiae* of 2 to 1« per year
(tt-9 Million) wmiM he
e«cee«V«1 by an unknown
mnunt. PmlMhle retail
price/ Increaaea
unknown).
Dlfolatan prnvlrtna
equivalent control
Copper la lea* effective
Dodlne, dlnocap, mi Ifur
fkvllnn and trlphenyltln hydrtwIiV
NA
to
CM
-------
Table C
Hit*
rleld Crop*
Peanut*
Kloe
Soybean*
Sugar Beet*
Sugar Cane-
Seed place*
Mheat
Ornaenntala
Omaeental*
turf
Veritable*
NuahrooB*
Vegetable*
TOTAL
extant of Oee Quantity Aanoayl Applied
Unit* Treated 1 of 0.8. Ith*. Active Ingredient 1
332,000 acre* 22 150,500
442,300 acre* 22 29»,300
1,922,000 acre* 2.« 7«I,OOH
NA NA 13,500
NA NA 2*,000
NA NA 11,150 •
•
NA NA 125,000
NA NA 150,000
174 Billion lb*. SO 11,034
NA NA 150,500
2.47 to 2.71 Billion
Availability of BonmMlc
BoonoMlc Alternative* lepact
Chlorothakmtl. wmeb, dlfolatan NA
•Mncneeb. trlphwnyltln bydroetde
ooppera, other*
None $14.94 ailll Ion per year or
t21 tn M InonMt lona pi>r
lapacted acre. tlttl» or
no oxmieir l«|Mrt.
Thlibandaxola NA
NA NA
Norn NA
None NA
Olnocap, ohlorothalonll, captan NA
• Ineb. awneb, thtra*, thlopnnnate
anthyl, folpet. Mnnooieb, copper*,
aulphur, aMtlra*, nabiw, othara
Thlophanate, thlophamte-enthyl, NA
cadMiuM, cycloheiuMlde, POM,
ohlorothalonll. thtr**,
-aMnoocab, other*
tln^b NA
rolpat, aMoab, chlorothalonll, NA
dlnncap, captafol, anllailne,
other* .
~ Greater than *M.17 ollllon
to S5J.H Million. -
cvj
Baumi USOA 11*70}, USDA/IM O>A I»79I, IM EPA II9MI, US 0>A
Ltaltad to domatle UMQ* only. M*no*yl ua* for Cantral ftMrlcan banww production la not camld*r*
-------
2. Tolerance Reassessment
Tolerances have been established for residues of benomyl
on a wide range of raw agricultural products listed in MO
CPR 180.291*. The toxicity data considered in support of
establishing an acceptable daily intake (ADI) for benomyl
of 0.05 mg/kg/day are the following:
a. In a two-year rat feeding study, benomyl showed a
No-Observed-Effect-Level (NOEL) of 2,500 ppm (125
mg/kg/day). There were no treatment related effects
observed in the study. A maximum tolerated dose (MTD)
was not established.
b. In a two-year dog feeding study, benomyl showed a NOEL
of 500 ppm (12.5 mg/kg/day). The Lowest-Effect-Level
(LED was 2,500 ppm (62.5 mg/kg/day) based on biochemical
alterations, hepatic cirrhosis, decreased weight gain
and lower food consumption.
c. In a mouse teratology study, benomyl has been shown to
cause certain anomalies: cleft palate, supernumerary
ribs, and subnormal vertebral centrum. The NOEL was 50
mg/kg/day and the LEL, based on teratogenlc effects,
was 100 mg/kg/day.
d. In a 3 generation study on male and female rats, benomyl
produced decreased pup weanling weights at 500 ppm (25 mg/
kg/day) and higher dosage rates. The NOEL was 100 ppm
(5 mg/kg/day) and the LEL, based on decreased pup
weanling weights, was 500 ppm (25 mg/kg/day).
e. In rat teratology studies, benorayl was shown to cause
a significant Increase in microphthalmla, anophthalmia,
distended lateral ventricles, hydrocephaly and decreased
fetal weight. The NOEL was 30 mg/kg/day and the LEL
was 62.5 mg/kg/day based on microphthalmia and decreased
fetal weight.
The three generation reproduction study in the rat was de-
termined to be the most sensitive study for benomyl. There-
fore, the ADI for humans based on this study was calculated
to be 0.05 mg/kg/day, based on a NOEL of 5.0 mg/kg/day, and
a safety factor of 100. The maximum permissible Intake
(MPI) for a 60 kg adult is: 0.05 mg/kg/day x 60 kg » 3_
mg/day.
To date the tolerances granted have accounted for approxi-
mately 70.0% of the ADI with a theoretical maximum residue
contribution (TMRC) to the daily diet of approximately
2.0 mg/day (for an average 1.5 kg dally diet).
25
-------
The potential impact of each new use on the ADI and other
toxic end points, Including oncogenlclty, teratogenlcity and
adverse spermatogenlc effects will be considered before
additional tolerances are granted.
Presently, the adequacy of the established tolerances for
the combined residues of benomyl and MBC (calculated as
benomyl) In certain raw agricultural commodities (RAC's)
and food/feed commodities cannot be determined until the
required metabolism studies In plants and animals, residue
and processing studies have been submitted and reviewed.
Pending receipt of the additional studies, the Agency will
evaluate new uses and new tolerances on a case-by-case
basis. If the Incremental risks are not significantly
increased, the Agency will continue to establish new
tolerances.
26
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D. REGULATORY POSITION AND RATIONALE.
Based on the review and evaluation of all available data and
other relevant information on benomyl, the Agency has made the
following determinations:
1. The Agency will not place benomyl and its metabolite MBC
into Special Review [Section 162.11(a) of CFR 40].
Rationale; Benomyl .was previously placed in Special Review
by the Agency in December/ 1977, because of its mutagenic,
teratogenic, reduced spermatogenic, and acute aquatic
effects. Prior to the publication of the final benomyl
regulatory decision, new studies were received by the Agency,
indicating that benomyl and its major metabolite, methyl-2-
benzimidazole carbamate (MBC) were carcinogenic.
Benomyl has been classified as a Group C oncogen (possible
human oncogen). The current risk analysis is of the same
order of magnitude as those calculated in the PD-4.
Although benomyl and its metabolite MBC are both associated
with liver tumors in Swiss and Swiss derived mice (CD-I),
MBC is not associated with liver tumors in the NMRKf strain
of mouse, which has a low background incidence of liver
tumors. Also benomyl and MBC were not oncogenic in the rat
and are not genotoxic. In addition, only one type of liver
tumors (hepatocellular carcinomas) occurred in both sexes
of the mice.
The Agency concluded that benomyl and its metabolite, MBC,
are spindle poisons which could result in aneuploidy and
nondisjunction. However, the impact of this effect to
human health could not be fully assessed at that time.
The state of the art for mutagenic risk assessment has not
changed significantly since the regulatory decision in 1982.
The Agency is still unable to perform a mutagenic risk as-
sessment for these compounds.
In a mouse teratology study, benomyl has been shown to cause
cleft palate, supernumerary ribs, and subnormal vertebral
centrum. The NOEL was 50 mg/kg/day and the LEL was 100
mg/kg/day.
In rat teratology studies, benomyl was shown to cause a
significant increase in microphthalmia, anophthalmia, distended
lateral ventricles, hydrocephaly and decreased fetal weight.
The NOEL of 30 mg/kg/day for teratogenic effects in the PD-4
was considered to be provisional until an effect level for
microphthalmia in rats could be determined. The Agency has
since reviewed a rat teratology study with special emphasis
on ocular effects and has determined that the NOEL for
microphthalmia is 30 mg/kg/day and the LEL is 62.5 mg/kg/day.
-------
The spermatotoxic risk for benomyl has not changed since the
1982 regulatory decision. Therefore, in order for the
MOS for aerial mixer/loaders to be acceptable/ a dust mask
must be worn while mixing and loading as required in the
1982 decision.
After considering dietary and applicator exposures to
benomyl, the Agency has determined that inhalation exposure
is the primary route of exposure to benomyl. Mainly, workers
who mix and load benomyl for aerial application have the
highest exposure.
In the PD-4, the Agency required* the use of a dust mask by
persons who mix and load benomyl for aerial application.
The Agency will maintain the identical protective mask
requirement in this registration standard.
The Agency has concluded that the risks to humans posed by
benomyl are minimal and of the same magnitude as in the
1982 decision. The Agency has also reviewed the benefits
of benomyl and has concluded that the benefits have not
changed significantly since the 1982 decision. The benefits
of benomyl outweigh its risks with the protective measures
required on the label. —Hence initiation of an additional
special review is not necessary at this time.
Concerns about the acute effects of benomyl on aquatic
species are discussed below.
2. The Agency does not intend to establish new food additive
regulations pursuant to to Section 409 of the Federal, Food,
Drug, and Cosmetic Act (FFDCA). The Agency is deferring
action on the presently established food additive regulations
until receipt and evaluation of comments in response to a
Federal Register notice discussing this issue. This notice
is scheduled for issuance in May, 1986.
Rationale; The Delaney Clause in Section 409 of the FFDCA
bars the establishment of food additive regulations for subs-
tances which induce cancer in man or test animals, with ex-
ceptions which do not apply here. Benomyl and its MBC
metabolite have been found to produce an oncogenic response
in test animals. The Agency will be soliciting comments on
Delaney clause issues regarding benomyl and other pesticides
which have produced positive oncogenic rsponses in chronic
animal studies.
3. The Agency will announce in a Federal Register Notice, the
availability of this interim Benomyl Registration Standard
to all interested persons for comment.
Rationale; The Agency will ask for public comments on its
classification of benomyl as a Group C oncogen. The Agency
emphasizes that the toxicology data base for benomyl is al-
most complete. Only the subchronic inhalation and general
metabolism studies are required.
28
-------
4. The Agency will submit this interim benomyl standard to the
Scientific Advisory Panel (SAP) for discussion of benomyl's
classification as a Group C oncogen.
Rationale; Although the Agency had previously submitted
the Benomyl PD-4 to SAP, it did not at that time classify
oncogens as presently required by the proposed Agency
cancer guidelines [Federal Register, Part VII, 19 (227):
46291-16301]. The Agency has included a risk assessment
for oncogenicity in this interim benomyl standard. The
Agency will request comments from SAP on the classification
of benomyl and the weight the Agency should place on this
risk assessment. After receipt of comments by the SAP and
Interested members of the public, the Agency will make any
appropriate revisions to the interim Benomyl Registration
Standard.
5. The Agency will approve a new use for a Section 3 or 21(c)
registration for benomyl on a case-by-case basis.
Rationale: Extensive data gaps exist in the areas of environ-
mental fate, residue chemistry and ecological effects. Until
the Agency reviews the data required In this standard, It can-
not fully assess the potential hazards of increased and/or
new uses of benomyl.
6. The Agency will consider Section 18 Exemptions for benomyl
on a case-by-case basis.
Rationale: Emergency exemption to use benomyl by a Federal or
State agency will only be granted after stringent review of
each pest outbreak shows that the temporary application of
benomyl will not cause adverse effects to non-target species
and the ecosystem.
7. The Agency is requiring a rice field monitoring study using
caged catfish in various sites and residue analyses with a
limit of detection of 1.0 ppb to determine the degree of risk
due to benomyl use.
Rationale; The monitoring study of benomyl residues in rice
field water submitted to the Agency as required by the
3(c)(2)(B) letter was found to be Inadequate. The Agency
is concerned about benomyl residue levels of 1.0 ppb. A
detection level of 20 ppb for the analytical methodolgy was
used in the monitoring study. Because this level of detection
is not adequate to alleviate concern for aquatic organisms,
a new monitoring study Is required.
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8. The Agency is requiring endangered species labeling on
benomyl EPs registered for use on soybeans. Currently,
the Agency is not requiring endangered species labeling
for use on rice, but mollusk data are being required (See
Part II, Section C).
Rationale; Benomyl was reviewed as part of the soybean clus-
ter for endangered species implications and in light of a
previous consultation with the Office of Endangered Species,
Department of the Interior, for an herbicide used on rice.
Review under the soybean cluster showed that two endangered
ictalurid species reside in areas where soybeans may be
grown. In order to protect these species from harm,
endangered species labeling is required.
The Fat Pocketbook Pearly mussel is associated with rice
culture. However, due to the absence of mollusk data, no
risk assessment can be conducted for this species at this
time. Therefore, endangered species labeling associated
with the rice use is not required. Instead, the Agency is
requiring data which will allow a risk assessment to be
conducted on this mussel.
9. The Agency is not requiring a reentry interval for currently
registered uses of benomyl.
Rationale; The acute toxicity for benomyl is low (Categories
III and IV) except for eye irritation (Category II) which
was reversible by 11 days. Additionally, exposure and the
resultant risks to field workers are not expected to be
significant. Therefore, no reentry interval is required.
10. The Agency is imposing labeling requirements which prohibit
grazing on treated wheat hay (forage), and grazing and feeding
of livestock on forage and nay of barley, oats, rye and
wheat following seed treatment (See Part II, Section C).
Rationale; The Agency is concerned that the grazing of live-
stock on treated wheat hay, and the grazing and feeding of
livestock on forage and hay of barley, oats, rye and wheat
following seed treatment may result in illegal residues in
those animals. Therefore, until data are received allevi-
ating the Agency's concerns, the Agency is imposing these
restrictions.
11. The Agency is imposing labeling restrictions on rotational
and irrigated crops. The extent of the restrictions will
be reconsidered when additional data are submitted and
reviewed (See Part II, Section C).
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Rationale: The Agency lacks data at the present time to
determine whether planting an unregistered crop In benomyl
treated soil or Irrigating an unregistered crop with water
from benomyl treated rice fields would result In Illegal
residues In these unregistered crops. In the absence of the
necessary data to make this determination, the restriction
will serve to protect the public from Impermlssable residues
In food and feed. In addition, this restriction will protect
subsequent planted crops from possible effects due to per-
sistent residues of benomyl In the soil and the Irrigation
water.
12. Available data are Insufficient to fully assess the environ-
mental fate of benomyl and exposure of nontarget organisms
to benomyl.
Rationale; In the ecosystem, the available Information Indi-
cates that benomyl dissipates (95%) in a variety of soils
from fine sand to sllty clay loam soils In less than 3
months. In the laboratory, the mobility of benomyl and MBC
In silt loam and sandy loam soils was found to be low.
In order to better define the environmental fate of benomyl,
the Agency is requiring studies on benomyl In soil metabolism,
mobility, soil/aquatic dissipation, and accumulation studies
(except for aquatic non-target organisms).
13> The Agency has reviewed five environmental fate studies for
benomyl submitted under Section 3(c)(2)(B) and concluded
that benomyl and MBC have a low potential for ground water
contamination.
Rationale; Both benomyl and MBC do not leach significantly
In soil and are not likely to contaminate ground water
supplies when applied properly for agricultural purposes.
1ft. The Agency will issue registrations for substantially similar
products. However new uses will be Issued only on a case-by-
case basis after considering the oncogenic risks and other
risks to applicators and dietary risks to the general public.
Rationale; Section 6 of FIFRA authorizes the Administrator
to cancel a pesticide registration if he determines that
the pesticide will cause unreasonable adverse effects on
the environment. Based on available data, the Administrator
has not made such a determination on benomyl. The Adminis-
trator has authority under FIFRA sections 3(c)(2)(B) and
(3)(c)(7) to require registrants and applicants for regis-
tration to provide data needed to support new or continuing
registrations.
While the data gaps are being filled, currently registered
manufacturing-use products (MPs) and end-use products (EPs)
containing benomyl as the sole active ingredient may be sold,
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distributed, formulated and used in the United States, sub-
ject to the terms and conditions specified in this Standard,
Registrants must provide or agree to develop additional
data, as specified in Table A of Appendix I, in order to
maintain existing registrations.
Issuance of this Standard provides a mechanism for identify-
ing data needs. These data will be reviewed and evaluated
and the Agency will determine if the data will affect the
registration of benomyl.
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PART II. REQUIREMENTS FOR REGISTRATION
This Part of the Registration Standard discusses the criteria for
registration, acceptable ranges and limits, and specific
labeling requirements. The Appendices contain information on
data requirements and instructions for submitting necessary
data and information to the Agency.
A. CRITERIA FOR REGISTRATION UNDER THIS STANDARD.
To be covered by this Standard, MPs must contain benomyl as
the sole active ingredient, bear required labeling and
conform to the product composition, acute toxicity limits
and use pattern requirements listed in Section B.
The applicant for registration or reregistration of
products subject to this Standard must comply with all
terms and conditions described in it. This includes
making a commitment to fill data gaps on a schedule
specified by the Agency. Applicants for registration
under this Standard must follow the instructions contained
herein and complete and submit the appropriate forms
within the time specified.
B. ACCEPTABLE RANGES AND LIMITS.
1. Product Composition Standard. Technical grade products
must contain at least 95.0 percent benomyl as the sole
active ingredient. Each MP formulation proposed for
registration must be fully described with appropriate
certification of limits. In addition, the active
ingredient must be substantially similar to that in
currently registered technical products. Any MPs not
meeting these requirements will be considered a new
product and will not be registered under this Standard.
2. Acute Toxicity Limits. The Agency will consider registration
of technical grade MPs containing benomyl when the acute
toxicity categories are no higher than Category II. The
labeling of any registered products must bear the appropriate
precautionary statements.
3. Use Patterns. To be registered under this Standard, MPs
containing benomyl must be labeled for reformulation into
end-use products which are systemic fungicides for use on
a variety of field and vegetable crops, rice, tree fruit
and nut crops, greenhouse, domestic outdoor(ornamental) and
turf sites. Benomyl is also used as a postharvest dip for
fruits; a preplant dip for seed pieces of pineapple and
sugar cane, and for strawberry transplants. [See the Benomyl
EPA Index to Pesticide Chemicals under Appendix III].
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C. REQUIRED LABELING.
The required label statements must appear on the labels of all
products in channels of trade within two years [April 30, 1988]
of issuance of this Standard. After review of data to be
submitted under this Standard/ the Agency may impose additional
label requirements.
All products must bear appropriate labeling as specified in 40
CFR 162.10. Specific information regarding 40 CFR 162.10
label requirements is included in Appendix II.
1. Manufacturing-Use Product Statements
All products intended for formulation into EPs must bear
the following environmental hazard statement:
"This product is toxic to fish."
"Do not discharge effluent containing this product di-
rectly into lakes, streams, ponds, estuaries, oceans
or public waters unless this product is specifically
identified and addressed in a National Pollutant Dis-
charge Elimination System (NPDES) permit. Do not dis-
charge effluent containing this product into sewer
systems without previously notifying the sewage treat-
ment plant authority. For guidance, contact your State
Water Board or Regional Office of the Environmental
Protection Agency".
2. End-Use Product Statements
The following human hazard statement must appear on all
EP labels:
"A cloth or disposable mask must be worn by all workers
engaged in mixing and loading benomyl for aerial
application."
The following environmental hazard statement must appear
on all EPs registered for non-aquatic uses:
"This pesticide is toxic to fish. Do not apply directly
to water. Drift and runoff from treated areas may be
hazardous to fish in adjacent areas. Do not contaminate
water by cleaning of equipment or disposal of wastes."
The following environmental hazard statement must appear
on all EPs registered for aquatic uses (e.g. rice):
"This pesticide is toxic to fish. Aquatic organisms may
be killed at recommended application rates. Do not
contaminate water by cleaning of equipment or disposal
of wastes."
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The following restriction on rotational crops and use of
irrigation water must appear on the label of all EPs:
"Do not use benomyl on rice fields in which crayfish and
catfish farming are included in the cultural practices.
Do not use water containing benomyl residues from rice cul-
tivation to irrigate crops unless benomyl is registered for
use on those crops. Do not plant food and feed crops in
benomyl treated fields for 18 months after the last appli-
cation unless benomyl is registered for use on those crops."
The following restriction on grazing and feeding must appear
on the label of all EPs:
"Grazing or feeding livestock is prohibited on forage and
hay of benomyl treated wheat, and on forage and hay of
barley, oats, rye and wheat following seed treatment."
The following information on endangered species must appear
on the label of all EPs registered for use on soybeans:
"ENDANGERED SPECIES RESTRICTIONS
The use of any pesticide in a manner that may kill or other-
wise harm an endangered~~or threatened species or adversely
modify their habitat is a violation of federal laws. The
use of this product is controlled to prevent death or harm
to endangered or threatened species that occur in the fol-
lowing counties or elsewhere in their range.
STATE
Species
OHIO
Scioto madtom
TENNESSEE
Yellowfin madtom
VIRGINIA
Yellowfin madtom
COUNTY
CHAMPAGNE
FRANKLIN
LOGAN
MADISON
PICKAWAY
UNION
CLAIBORNE
HANCOCK
LEE
RUSSELL
SCOTT
Before using this pesticide in these counties you must obtain
the EPA Cropland Endangered Species Bulletin (EPA/ES-CROP).
The use of this pesticide is prohibited in these counties
unless specified otherwise in the Bulletin. The EPA Bulletin
is available from either your County Agricultural Extension
Agent, the Endangered Species Specialist in your State
Wildlife Agency Headquarters, or the appropriate Regional
Office of either the U.S. Fish and Wildlife Service (FWS)
or the U.S. Environmental Protection Agency (EPA). THIS
BULLETIN MUST BE REVIEWED PRIOR TO PESTICIDE USE."
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D. PRODUCTS SUBJECT TO THIS STANDARD
All products containing one or more of the pesticides
identified in Part I.A. are subject to certain requirements
for data submission or changes in composition, labeling or
packaging of the product. The applicable requirements depend
on whether the product is a manufacturing or end use product
and whether the pesticide is the sole active ingredient or
one of multiple active ingredients.
Products are subject to this Registration Standard as
follows:
1. Manufacturing use products containing this pesticide as
the sole active ingredient are subject to:
a. The restrictions (if any) upon use, composition, or
packaging listed in Part I, if they pertain to the
manufacturing use product.
b. The data requirements listed in Tables A and B2
c. The labeling requirements specified for manufacturing
use products in Part II.
d. Administrative requirements (application forms, Confiden-
tial Statement of Formula, data compensation provisions)
associated with reregistration.
2 Data requirements are listed in the three Tables in
Appendix I of this Registration Standard. The Guide to
Tables in that Appendix explains how to read the Tables.
Table A lists generic data requirements applicable to all
products containing the pesticide subject to this Registra-
tion Standard. Table B lists product-specific data applicable
to manufacturing use products. The data in Tables A and B
need not be submitted by a producer who is eligible for the
formulator's exemption for that active ingredient.
Table C lists product-specific data applicable to end use
products. The Agency has decided that, in most cases, it
will not require the submission of product-specific data for
end use products at this time. Therefore most Registration
Standards do not contain a Table C.
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2. Manufacturing use products containing this pesticide
as one of multiple active ingredients are subject to:
The data requirements listed in Table A.
3. End use products containing this pesticide as the
sole active ingredient are subject to:
a. The restrictions (if any) upon use, composition, or
packaging listed in Part I if they pertain to the
end use product.
b. If eligible for the formulator's exemption^. the
data requirements listed in Table C.
c. If not eligible for the forraulator's exemption, the
data requirements listed in Table A and the data require-
ments listed in Table C.
d. The labeling requirements specified for end use
products in Part II.
4. End use products containing—this pesticide as one of
multiple active ingredients are subject to:
a. If not eligible for the formulator's exemption,
the date requirements listed in Tables A and C.
b. If eligible for the formulator's exemption, the
data requirements listed in Table C.
3 If you purchase from another producer and use as the
source of your active ingredient only EPA-registered products,
you are eligible for the formulator's exemption for generic
data concerning that active ingredient (Table A) and product-
specific data for the registered manufacturing use product
you purchase (Table B).
Two circumstances nullify this exemption:
1) If you change sources of active ingredient to an
unregistered product, formulate your own active ingredient,
or acquire your active ingredient from a firm with ownership
in common with yours, you individually lose the exemption
and become subject to the data requirements in Table A.
2) If no producer subject to the generic data requirements
in Table A agrees to submit the required data, all end use
producers lose the exemption, and become subject to those
data requirements.
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E. REQUIREMENT FOR SUBMISSION OF GENERIC DATA
This portion of the Registration Standard is a notice
issued under the authority of FIFRA sec. 3(c)(2)(B). It
refers to the data listed in Table A, which are required to
be submitted by registrants to maintain in effect the regis-
tration of products containing this active ingredient.*
1. What are generic data?
Generic data pertain to the properties or effects of a
particular active ingredient. Such data are relevant to an
evaluation of all products containing that active ingredient
regardless of whether the product contains other ingredients.
(unless the product bears labeling that would make the data
requirement inapplicable).
Generic data may also be data on a "typical formulation"
of a product. "Typical formulation" testing is often required
for ecological effects studies and applies to all products
having that formulation type. These are classed as generic
data, and are contained in Table A.
2. Who must submit generic data?
All current registrants are responsible for submitting
generic data in response to a data request under FIFRA sec.
3(c)(2)(B) (DCI Notice). EPA has decided, however, not to
require a registrant who qualifies for the formulator's
exemption (FIFRA sec. 3(c)(2)(D) and 5 152.85) to submit
generic data in response to a DCI notice if the registrant
who supplies the active ingredient in his product is complying
with the data request.
If you are not now eligible for a formulator's exemption,
you may qualify for one if you change your source of supply
to a registered source that does not share ownership in
common with your firm. If you choose to change sources of
supply, the Confidential Statement of Formula must identify
the new source(s) and you must submit a Formulator's Exemption
Statement form.
If you apply for a new registration for products containing
this active ingredient after the issuance of this Registration
Standard, you will be required to submit or cite generic
data relevant to the uses of your product if, at the time
4 Registrations granted after issuance of this Standard
will be conditioned upon submission or citation of the data
listed in this Registration Standard.
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the application is submitted, the data have been submitted
to the Agency by current registrants. If the required data
have not yet been submitted, any new registration will be
conditioned upon the new registrant's submission or citation
of the required data not later than the date upon which
current registrants of similar products are required to provide
such data. See FIFRA sec. 3(c)(7)(A). If you thereafter fail
to comply with the condition of that registration to provide
data, the registration may be cancelled (FIFRA sec. 6(e)).
3. What generic data must be submitted?
You may determine which generic data you must submit by
consulting Table A. That table lists the generic data needed
to evaluate current uses of all products containing this
active ingredient, the uses for which such data are required,
and the dates by which the data must be submitted to the
Agency.
4. How to comply with PCI requirements.
Within 90 days of your receipt of this Registration
Standard, you must submit to EPA. a completed copy of the form
entitled "FIFRA Section 3(c)(2)(B) Summary Sheet" (EPA Form
8580-1, enclosed) for each of your products. On that form
you must state which of the following six methods you will
use to comply with the DCI requirements:
a. You will submit the data, and either—
(1) Submit the existing data that you believe will
satisfy the data requirements, or
(2) State that you will secure the data or have made
a contract to have any necessary studies completed
within the applicable time period.
b. You have entered into an agreement with one or more
registrants to jointly develop (or share in the cost of
developing) the data, but will not be submitting the data
yourself. If you use this method, you must state who will
submit the data on which you will rely. You must also provide
EPA with documentary evidence that an agreement has been
formed which allows you to rely upon the data to be submitted.
Such evidence may be: (1) your letter offering to join in
an agreement and the other registrant's acceptance of your
offer, (2) a written statement by the parties that an agreement
exists, or (3) a written statement by the person who will be
submitting the data that you may rely upon its submission.
The Agency will also require adequate assurance that the
person whom you state will provide the data is taking appropriate
steps to secure it. The agreement to produce the data need
not specify all of the terms of the final arrangement between
the parties or a mechanism to resolve the terms.
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c. You have attempted to enter into an agreement to
jointly develop data, but no other registrant has accepted
your offer. You request that EPA not suspend your registration
for non-compliance with the PCI. EPA has determined that,
as a general policy, it will not suspend the registration of
a product when the registrant has in good faith sought and
continues to seek to enter into a data development/cost
sharing program, but the other registrants developing the
data have refused to accept its offer. [If your offer is
accepted, you may qualify for Option 2 above by entering
into an agreement to supply the data.]
In order to qualify for this method, you must:
1. File with EPA a completed "Certification of Attempt
to Enter into an Agreement with other Registrants for Develop-
ment of Data" (EPA Form 8580-6, enclosed).
2. Provide us with a copy of your offer to the other
registrant and proof of the other registrant's receipt of your
offer (such as a certified mail receipt). Your offer must,
at a minimum, contain the following language or its equivalent:
[Your company name] offers to share in the burden of
producing the data required pursuant to FIFRA sec.
3(c)(2)(B) in the.[name of active ingredient] Registration
Standard upon terms to be agreed or failing agreement
to be bound by binding arbitration as provided by FIFRA
section 3(c)(2)(B)(iii).
The remainder of your offer may not in any way attempt to
limit this commitment. If the other registrant to whom your
offer is made does not accept your offer, and if the other
registrant informs us on a DCI Summary Sheet that he will
develop and submit the data'required under the DCI, then you
may qualify for this option. In order for you to avoid
suspension under this method, you may not later withdraw or
limit your offer to share in the burden of developing the
data. In addition, the other registrant must fulfill its
commitment to develop and submit the data.
d. You request a waiver of the data requirement. If
you believe that a data requirement does not (or should not)
apply to your product or its uses, you must provide EPA with
a statement of the reasons why you believe this is so. Your
statement must address the specific composition or use factors
that lead you to believe that a requirement does not apply.
Since the Agency has carefully considered the composition and
uses of pesticide products in determining that a data require-
ment applies, EPA does not anticipate that many waivers will
be granted. A request for waiver does not automatically
extend the timeframes for developing required data, and if
your waiver request is denied, your registration may be
suspended if you fail to submit the data.
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e. You request that EPA amend your registration by deleting
the uses for which the data are needed. You are not required
to submit data for uses which are no longer on your label.
f. You request voluntary cancellation of the registration
of your product(s) for which the data are needed.
5. Procedures for requesting a change in testing protocol.
If you will generate the required data and plan to use
test procedures which deviate from (or are not specified in)
either EPA's Pesticide Assessment Guidelines or the Reports
of Expert Groups to the Chemicals Group, Organization for
Economic Cooperation and Development (OECD) Chemicals Testing
Programme, you must submit for EPA approval the protocols
you propose to use.
You should submit your protocols before beginning testing
and await EPA approval, because the Agency will not ordinarily
accept as sufficient studies using unapproved protocols.
A request for protocol approval will not automatically extend
the timeframe for submission of the data, nor will extensions
generally be given to conduct studies due to submittal of
inappropriate protocols. __
6. Procedures for requesting extensions of time.
If you think that you will need more time to generate
the data than is allowed by EPA's schedule, you may submit a
request for an extension of time. Any request for a time
extension which is made as an initial response to a section
3(c)(2)(B) request notice must be submitted in writing to
the Product Manager listed at the end of this section and
must be made before the deadline for response. Once dates
have been committed to and EPA has accepted these commitments,
any subsequent requests for a time extension must be submitted
in writing to the Office of Compliance Monitoring.
EPA will view failure to request an extension before
the response deadline as a waiver of any future claim that
there was insufficient time to submit the data. While EPA
considers your request, you must strive to meet the deadline
for submitting the data.
The extension request should state the reasons why you
believe that an extension is necessary and the steps you
have taken to meet the testing deadline. Time extensions
normally will not be granted due to problems with laboratory
capacity or adequacy of funding, since the Agency believes
that with proper planning these can be overcome. Time extensions
may be considered when joint data development is planned,
or when the Agency must approve a new or modified protocol
before the study can be begun.
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A request for an extension does not automatically extend
the timeframe for submission of the data. If EPA denies your
request for a time extension and you do not submit the data
as requested, EPA may begin proceedings to suspend the regis-
trations of your products.
7. Existing stocks provision upon suspension or cancellation.
EPA will permit continued sale and distribution of existing
stocks of a pesticide product which has been suspended or
cancelled if doing so would be consistent with the purposes
of the Act. However, the Agency has determined that if a
registration is suspended for failure to respond to a DCI
request under FIFRA sec. 3(c)(2)(B), an existing stocks
provision is not consistent with the Act. Accordingly, the
Agency does not anticipate granting permission to sell or
distribute existing stocks of suspended product except in
rare circumstances. If you believe that your product will
be suspended or cancelled and that an existing stocks provision
should be granted, you have the burden of clearly demonstrating
to EPA that granting such permission would be consistent with
the Act. The following information must be included in any
request for an existing stocks provision:
a. Explanation of why an -e-xisting stocks provision is
necessary, including a statement of the quantity of
existing stocks and your estimate of the time required
for their sale or distribution; and
b. Demonstration that such a provision would be consis-
tent with the provisions of FIFRA.
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F. REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA
Under its DCI authority, EPA has determined that certain
product-specific data are required to maintain your registrations
in effect. Product-specific data are derived from testing
using a specific formulated product, and, unlike generic
data, generally support only the registration of that product.
All such data must be submitted by the dates specified in
this Registration Standard.
If you have a manufacturing use product, these data are
listed in Table B. If you have an end use product, the data
are listed in Table C. As noted earlier, the Agency has
decided that it will not routinely require product-specific
data for end use products at this time. Therefore, Table C
may not be contained in this Registration Standard; if there
is no Table C, you are not required to submit the data at
this time.
In order to comply with the product specific data require-
ments, you must follow the same procedures as for generic data.
See Section E.4, 5, 6, and 7. You should note, however, that
product chemistry data are required for every product, and the
only acceptable responses are options E.4.a. (submit data)
or E.4.f.(cancellation of registration).
Failure to comply with the product-specific data require-
ments for your products will result in suspension of the
product's registration.
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G. REQUIREMENT FOR SUBMISSION OF REVISED LABELING
FIFRA requires each product to be labeled with accurate,
complete and sufficient instructions and precautions, reflecting
the Agency's assessment of the data supporting the product
and its uses. General labeling requirements are set out in
40 CFR 162.10 (see Appendix II - LABELING). In addition,
labeling requirements specific to products containing this
pesticide are specified in Part II.C of this Registration
Standard. Applications submitted in response to this notice
must include draft labeling for Agency review.
If you fail to submit revised labeling as required,
which complies with 40 CFR 162.10 and the specific instructions
in Part II.C, EPA may issue a Notice of Intent to Cancel
the registration of your product under FIFRA sec. 6(b)(l).
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H. INSTRUCTIONS FOR SUBMISSION
1. Manufacturing Products (MUPs) containing benomyl
as sole active ingredient.
a. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division
for each product subject to this Registration Standard:
(1) The "FIFRA Section 3(c)(2)(B) Summary Sheet" (EPA
Form 8580-1), with appropriate attachments.5
(2) Confidential Statement of Formula (EPA Form 8570-4).
(3) Formulator's Exemption Statement (EPA Form ).
(4) Product Specific Data Report (EPA Form 8580-4).
(5) Evidence of compliance with data compensation
requirements of FIFRA sec. 3(c)(l)(D). Refer to 40 CFR
152.80-152.99.
b. Within 12 months from receipt of this document you
must submit to the Product Manager:
(1) Two copies of any required product-specific data
(See Table B or C).
(2) Three copies of draft labeling, including the
container label and any associated supplemental labeling.
Labeling should be either typewritten text on 8-1/2 x 11
inch paper or a mockup of the labeling suitable for
storage in 8-1/2 x 11 files. The draft label must indicate
the intended colors of the final label, clear indication
of the front panel of the label, and the intended type
sizes of the text.
5 If on the Summary Sheet, you commit to develop the data,
present arguments that a data requirement is not applicable
or should be waived, or submit protocols or modified protocols
for Agency review, you must submit a copy of the Summary
Sheet (and any supporting information) to the Office of
Compliance Monitoring, which will be monitoring the data
generated in response to this notice. This submission is in
addition to responding to the Product Manager, and should be
submitted to the Office of Compliance Monitoring at the
address given at the end of this section. (Actual studies
are not to be submitted to the Office of Compliance Monitoring.)
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c. Within the times set forth in Table A, you must
submit to the Registration Division all generic data, unless
you are eligible for the formulator's exemption. If for any
reason any test is delayed or aborted so that the agreed
schedule cannot be met, immediately notify the Product Manager
and the Office of Compliance Monitoring of the problem, the
reasons for the problem, and your proposed course of action.
2. Manufacturing Use Products containing benomyl in combination
with other active ingredients.
a. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division:
(1) FIFRA sec. 3(c)(2)(B) Summary Sheet, with appropriate
attachments5 (EPA Form 8580-1).
(2) Confidential Statement of Formula (EPA Form 8570-4)
(3) Formulator's Exemption Statement (EPA Form ),
if applicable.
b. Within the time frames ITet forth in Table A, you must
submit to the Registration Division all generic data, unless
you are eligible for the formulator's exemption. If for any
reason any test is delayed or aborted so that the agreed
schedule cannot be met, immediately notify the Product Manager
and the Office of Compliance Monitoring of the problem, the
reasons for the problem, and your proposed course of action.
3. End Use Products containing benomyl alone or in combination
with other active ingredients.
a. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division:
(1) FIFRA Section 3(c)(2)(B) Summary Sheet, with
appropriate attachments5 (EPA Form 8580-1).
(2) Confidential Statement of Formula (EPA Form 8570-4).
(3) Formulator's Exemption Statement (EPA Form ),
if applicable.
(4) Product Specific Data Report (EPA Form 8580-4),
if Table C lists required product-specific data.
b. Within 12 months from receipt of this document you
must submit to the Product Manager:
(1) Two copies of any product-specific data, if required
by Table C.
46
-------
(2) Three copies of draft labeling, including the
container label and any associated supplemental labeling.
Labeling should be either typewritten text on 8-1/2 x 11
inch paper or a mockup of the labeling suitable for
storage in 8-1/2 x 11 files. The draft labeling must
indicate the intended colors of the final label, clear
indication of the front panel of the label, and the
intended type sizes of the text. End use product labeling
must comply specifically with the instructions in Part II
(Requirements for Registration).
4. Intrastate Products containing benomyl either as sole
active ingredient or in combination with other active
ingredients.
These products are being called in for full Federal regis-
tration. Producers of these products are being sent a letter
instructing them how to submit an application for registration.
5. Addresses
The required information must be submitted to the following
address: —
Henry Jacoby, PM 21
Registration Division (TS-767C)
Office of Pesticide Programs
Environmental Protection Agency
401 M St., SW
Washington, D.C. 20460
The address for submissions to the Office of Compliance
Monitoring is:
Laboratory Data Integrity Program
Office of Compliance Monitoring (EN-342)
Environmental Protection Agency
401 M St., SW
Washington, D.C. 20460.
47
-------
I. DATA APPENDICES
Guide to Tables
Table A
Table B
48
-------
TGUIDE-1
GUIDE TO TABLES
Tables A, B, and C contain listings of data requirements
for the pesticides covered by this Registration Standard.
Table A contains generic data requirements that apply to
the pesticide in all products, including data requirements
for which a "typical formulation" is the test substance.
Table B contains product-specific data requirements that
apply only to a manufacturing use product.
Table C contains product-specific data requirements that
apply only to an end use product.
The data tables are generally organized according to the
following format:
1. Data Requirement (Column 1). The data requirements are
listed in the order in which they appear in 40 CFR Part 158.
The reference numbers accompanying each test refer to the
test protocols set out in the Pesticide Assessment Guidelines,
which are available from the Na-tdonal Technical Information
Service, 5285 Port Royal Road, Springfield, VA 22161.
2. Test Substance (Column 2). This column lists the composition
of the test substance required to be used for the test, as
follows:
TGAI = Technical grade of the active ingredient
PAI = Pure active ingredient
PAIRA = Pure active ingredient, radio labeled
TEP = Typical end use formulation
MP = Manufacturing use product
EP = End use product
Any other test substances, such as metabolites, will be
specifically named in Column 2 or in footnotes to the table.
3. Use pattern (Column 3). This column indicates the use
patterns to which the data requirement applies. Use patterns
are the same as those given in 40 CFR Part 158. The following
letter designations are used for the given use patterns:
A = Terrestrial, food
B = Terrestrial, non-food
C = Aquatic, food
D = Aquatic, non-food
E = Greenhouse, food
F = Greenhouse, non-food
G = Forestry
H = Domestic outdoor
I = Indoor
Any other designations will be defined in a footnote to the table
49
-------
TGUIDE-2
4. Does EPA have data? (Column 4). This column indicates one
of three answers:
YES - EPA has data in its files that completely satisfy
this data requirement. These data may be cited by
other registrants in accordance with data compensation
requirements of Part 152, Subpart E.
PARTIALLY - EPA has some data in its files, but such data
do not fully satisfy the data requirement. In some cases,
the Agency may possess data on one of two required species,
or may possess data on one test substance but not all.
The terra may also indicate that the data available to
EPA are incomplete. In this case, when the data are
clarified, or additional details of the testing submitted
by the original data submitter, the data may be determined
to be acceptable. If this is the case, a footnote to
the table will usually say so.
NO - EPA either possesses no data which are sufficient
to fulfill the data requirement, or the data which EPA
does possess are flawed scientifically in a manner that
cannot be remedied by clarification or additional infor-
mation.
5. Bibliographic citation (Column 5). If the Agency has
acceptable data in its files, this column lists the identifying
number of each study. This normally is the Master Record
Identification (MRID) number, but may be a GS number if no
MRID number has been assigned. Refer to the Bibliography
Appendices for a complete citation of the study.
6. Must additional data be submitted? (Column 6). This
column indicates whether the data must be submitted to the
Agency. If column 3 indicates that the Agency already has
data, this column will usually indicate NO. If column 3
indicates that the Agency has only partial data or no data,
this column will usually indicate YES. In some cases, even
though the Agency does not have the data, EPA will not require
its submission because of the unique characteristics of the
chemical; because data on another chemical can be used to
fulfill the data requirement; or because the data requirement
has been waived or reserved. Any such unusual situations
will be explained in a footnote to the table.
7. Timeframe for submission (Column 7). If column 5 requires
that data be submitted, this column indicates when the data
are to be submitted, based on the issuance date of the Regis*
tration Standard. The timeframes are those established either
as a result of a previous Data Call-in letter, or standardized
timeframes established by PR Notice 85-5 (August 22, 1985).
3. Footnotes (at the end of each table). Self-explanatory.
-------
TABLE A
GENERIC DATA REQUIREMENTS TOR BENOMYL
Guideline Citation and Test
Naiiio or Test Substance!/
§158.120 Product Chemistry
Product Identity:
61-1 - Product Identity and Disclosure
of Ingredient
61-2 - Description of Beginning Materials
and Manufacturing Process
61-3 - Discussion of Formation of
Impurities
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
62-2 - Certification of Limits
62-3 - Analytical Method for Enforcement
of Limits
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical State
63-4 - Odor
i 63-5 - Melting Point
i
63-6 - Rolling Point
LTI
TOAI
TOAI
TOAI
TOAI
TOAI
TOAI
TOAI
TOAI
TOAI
TOAI
TOAI
Guidelines
Status2/
R
R
R
CR
CR
CR
R
R
R
R
R
Are Data
Required
Yes No
n
[X]
n
1
o
[x]
[X]
n
n
n
n
n
c]p
n
np
[X]
n
n
[X]
[X]
[X]
[X]
ra
Data Must Be
Footnote Submitted Within
Number or Time Frames Llste
Citation Below3/
00067416, 00067121
6 months
00151522
00151523
12 months
00151523 6/ 12 months
(Partially)
00067^21, 00151521
00151521
00151521
00151521
*/
-------
TABLE A
GENRRIC DATA RRQUIREMENTS FDR BENOMYL
Guideline Citation and
Name of Test
Test
Substancel/
Data Must Be
Guidelines Are Data Footnote Submitted Within
Status2/ Required Number or Time Frames Listed
Yes No Citation Below3/
§158.120 Product Chemistry (Continued)
Physical and Chemical Characteristics
(Continued)
6>7 - Density, Bulk Density, or
Specific Gravity
63-8 - Solubility
63-9 - Vapor Pressure
63-10 - Dissociation constant
63-11 - Octano I/water partition
coefficient
63-12 - pH
63-13 - Stability
Other Requirements:
64- 1 - Submlttal of samples
TGAI
T3AI or PAI
PAI
PAI
PAI
TGAI
TGAI
TGAI, PAI
I/ TGAT = Technical Grade of the Active Ingredient;
2/ R = Required: CR = Conditionally Required.
3/ Data must be submitted within the Indicated time
~ 6 Month Due Date Is October 30, 1986.
12 Month Due Date Is April 30,
1987.
R
R
R
R
R
R
R
CR
PAI =
frame,
O
n
cu
n
6
[X]
n
O
EX] 00151521
[X] 00151521
[~] - 6 months
[x] 00151521
[x] 00151521
[~] 6 months
[X]
[X] 5
Pure Active Ingredient.
based on the date of the Guidance Document.
V This Is not required for benomyl since It Is a solid.
5/ This compound does not require the submlttal of samples at this time,
fi/ Information Is required on the detector utilized In the gas chromatographlc procedure for determining 1,3-dlbutylurea
In technical hencmyl.
Ui
-------
TAHLE A
GENERIC DATA REQUIREMENTS FDR BENOMYL
Data Requirements
Composition
Does EPA Have Data
To Satisfy This
I/ Requirement? (Yes,
No, or Partially)
Bibliographic
Citation
Mist Additional Data
Be Submitted Under
PIPRA § 3(c)(2)(B)7
Time Frames For Data
Submission ?/
§158.125 Residue Chemistry
171-2 - Chemical Identity TGAI
171-1 - Nature or Residue (Metabolism)
- Plants PAIRA
Yes
Partially
00067116, 00067121 No
00037185,
00037187,
00037189,
00037360,
00037362,
00037361,
00052322,
00097310,
00097605,
00097613,
00097628,
00037186
00037188
00037196
00037361
00037363
00038151
00097321
00097355
00097611
00097626
Yes 3/ 18 months
- Livestock
PAIRA and Plant
Metabolites
Partially
00035361, 00011601
00097581, 00097591
00100751,
Yes I/ 18 months
171-1 - Residue Analytical Method
- Plant and Animal Residues
and Metabolites Partially
00026012,
00016215,
00018098,
00097291,
00097338,
00097313,
00035360
00016819
00018099
00097308
00097312
00097311
Yes 5/15 months
cn
-------
TABLR A
OENERIC DATA REQUIREMENTS FOR BENOMYL
Data Requirements
Does EPA Have Data
To Satisfy This
_!/ Requirement? (Yes,
Composition No, OP Partially)
Bibliographic
Citation
Must Addlt
Be Submltt
PIFRA § 3(
Time Frame
Submlssior
171-'I - Residue Analytical Method (cont.)
- Plant and Animal Residues T3AI and Metabolites Partially
00097354, 00097580 Yes 5_/ 15 months
00097592, 00106600
171-1 - Storage Stability Data
171-4 - Magnitude of the Residue-
Residue Studies
- Crop Group: Root & Tuber
Vegetables
- Carrots
- Rutabagas
- Sugar beet roots
- Sweet potatoes
- Turnip roots
PAI
Partially 00026042, 00044906 Yes 6/ 18 months
00046245,
TEP
TEP
TEP
TEP
TEP
Partially
Partially
Yes
Yes
Partially
00035346, 00097259
00097590
00106030, 00097592
(See turnip data)
00035346, 00097259
00097303
00097580
00106030, 00097592
Yes 7/8/18 months
Yes 7/ 18 months
No 7/
No 7/
Yes 7/ 18 months
cn
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR BENOMYL
>ata Requirenients
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Time Frames For Data
Submission 2/
J158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies
- Crop Group: Leaves of Root
& Tuber Vegetables
- Sugar Beet Tops
- Turnip Tops
- Crop Group: Bulb Vegetable
- Garlic
TEP
TEP
TEP
Yes
Partially
I
Yes
00035346, 00097342
00106030
GSO119-029
No
Yes y 18 months
No
LTI
cn
Crop Group: Leafy Vegetables
- Celery TEP
- Dandelions TEP
- Spinach TEP
Crop Group: Brassica Leafy
Vegetables
- Broccoli TEP
- Brussels Sprouts TEP
- Cabbage TEP
- Cauliflower TEP
- Chinese Cabbage TEP
Partially
Partially
No
Partially
Yes
No
No
Yes
00097293
00128338
00106030
Yes 7/9/ 18 months
Yes 7/10/18 months
Yes 7/11/18 months
Yes 7/12/18 months
00106030, 00129169 No
00129168
Yes 7/13/18 months
Yes 7/14/18 months
No 7/
-------
TABLE A
GENERIC DATA REQUIREMENTS TOR BENOMYL
Data Requirements
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially
Bibliographic
Citation
- Crop Group: Legume
Vegetables
- Beans
- Soybeans
TEP
TEP
Yes
Partially
00035346, 00052321
00052324
00097349,
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Time Frame Eor Data
Submission 2/
$158.125 Residue Chemistry - Continued
- Crop Group: Brass ica Leafy
Vegetables
- Collards
- Kale
- Kohlrabi
- Mustard Greens
TEP
TEP
TEP
TEP
Partially
Partially
Partially
Partially
00106030,
00106030,
00106030,
00106030,
Yes 7/15/
Yes 7/15/
Yes 7/16/
Yes 7/17/
No 7/
Yes 7/18/ 18
Crop Group: Foliage of Legume
Vegetables
- Bean Vine Forage TEP
Crop Group: Fruiting
Vegetables
- Eggplant TEP
- Peppers TEP
- Tomatoes TEP
Partially 00035346, 00052321 Yes 7/19/ 18 months
00052323, 00052324
Yes 00046244, No T/
Partially 00046244, Yes 7/g0/ 18 months
Partially 00097347, 00097621 Yes 7/21/ 18 months
cn
ON
-------
TABLK A
GENERIC DATA REQUIREMENTS FOR BENOMYL
I/
Data Requiperaenta Composition
§158.125 Residue Chemistry - Continued
- Crop Group: Cucurbit
Vegetables
- Cucumbers TEP
- Melons TEP
- Pumpkins TEP
- Summer Squash TEP
- Winter Squash TEP
Does EPA Have Data Must Additional Data
To Satisfy This Be Submitted Under
Requirement? (Yes, Bibliographic FIFRA § 3(c)(2)(B)?
No, or Partially) Citation Time Frames Tor Data
Submission 2/_
Yes 00030771 ,
Yes 00003806,
00081915,
Yes 00003806,
00081915,
Yes 00081915,
Yes l 00003806,
00081915,
00081915
00030771
00097337
00030771
00097337
00097303
00030771
00097337
No ?/
No 7/
No 7/22/
No 7/
No T/22/
- Crop Group: Citrus Fruits
- Citrus Fruit TEP
- Crop Group: Pome Fruits
- Apples TEP
- Pears TEP
- Crop Group: Stone Fruits
- Apricots TEP
- Cherries TEP
01
Partially 00010272, 000973M Yes 7/23/18 months
Yes 00037365, 00063822 No 7/
00077070, 00097335
00098695
Yes 00037365 No 7/
Yes 00077070, 00097303 No 7/
00097316
Yes 00037182, 00077070 No y
00097303
-------
TABLR A
GENERIC DATA REQUIREMENTS FOR BENOMYL
Data Requirements
Composition
Does EPA Have Data
To Satisfy This
I/ Requirement? (Yes,
No, or PArtlally)
Bibliographic
Citation
Must Additional Data
Be Sumltted Under
PIPIRA § 3(c)(2)(R)7
Time Praine Tor Data
Submission ?_/
§158.125 Residue Chemistry - Contnued
- Crop Group: Stone Fruits
- Nectarines TEP
- Peaches TEP
- Plums (Fresh prunes) TEP
- Crop Group: Small Fruits
& Berries
- Blackberries TEP
- Blueberries TEP
- Boysenberries TEP
- Currants TEP
- Dewberries TEP
- Grapes TEP
- Loganberries TEP
- Raspberries TEP
- Strawberries TEP
- Crop Group: Tree Nuts
TEP
Ln
oo
- Nuts (Almonds, Macadamia
Nut, Pecans
Yes
Yes
Partially
Yes |
Yes
Yes
Yes
Yes
Partially
Yes
Yes
Partially
Yes
00077070, 00097303 No 7/
00077070, 00097303 No 7/
00097316
00037182, 00097303 Yes 7/2 V 18 months
00097315
00106600
00097315
00106600
00097315, 00106600
0005*1213, 00051216
00077070, 0097310
00097315, 00106600
00097315
00097269, 00097299
00097267, 00097306
00108623
No 7/
No 7/
No 7/
No 7/257
No 7/26/
Yes 7/27/ 18 months
No T/26/
No 7/
Yes 7/28/ 18 months
No 7/
-------
TABLR A
GENERIC DATA REQUIREMENTS FDR BENOMYL
Data Requirements
Composition
Does EPA Have Data
To Satisfy This
I/ Requirement? (Yes,
No, or Partially)
Bibliography
Citation
Must Additional. Data
Be Submitted Under
FIFIRA § 3(c)(2)(B)7
Time Frames Por Data
Submission ^L
§158.125 Residue Chemistry - Continued
- Crop Group: Cereal Grains
- Corn, Fresh (sweet kernals
+ cobs w/husks removed)
- Rice
- Barley grain
- Oat grain
- Rye grain
- Wheat grain
TEP
TEP
TEP
TEP
TEP
TEP
Partially
Partially
Partially
Partially
1
Partially
Partially
GS01 19-032
001306840
00097578, 00148204
00078626, 00097331
00097578
00078626, 00097331
00097578
00078626, 00097331
Yes 7/29/ 18 months
Yes 7/30/ 18 months
Yes 7/31/ 18 months
Yes 7./3J./ 18 months
Yes 7/31/ 18 months
Yes 7/3V 18 months
LH
Crop Group: Cereal Grains
(Forage, Fodder 4 Straw)
- Corn, sweet' (fodder 4 TEP
forage)
- Rice straw TEP
- Barley hay 4 straw TEP
- Oat hay 4 straw TEP
- Rye hay 4 straw TEP
- Wheat hay 4 straw TEP
Partially
Partially
Partially
Partially
Partially
Partially
00097578
GS0119-032
00130684
00078626, 00097578
00078626, 00097331
00097578
00078626, 00097331
00097578
00078626, 00097331
00097578
Yes T/32/ 18 months
Yes T/33/ 18 months
Yes 7/31/ 18 months
Yes 7/31/ 18 months
Yes 7/31/ l8 months
Yes 7/3I/ IB months
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR BENOMYL
Data Requirement
Composition
Does EPA Have Data
To Satisfy Tills
I/ Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
PIPRA § 3(c)(2)(B)7
Time Frames for Data
Submission ^/
§158.125 Residue Chemistry - Continued
171-4 - Magnitude of the Residue-
Residue Studies
- Crop Group (Miscellaneous
Commodities)
- Avocados TEP
- Bananas TEP
- Mangoes TEP
- Mushrooms TEP
- Papayas TEP
- Pineapples TEP
- Peanuts TEP
Magnitude of the Residue-
Residue Studies
Cattle, Goats, Hogs, Horses, TGAI or Plant
& Sheep (T%it, meat, & meat Metabolites
by-products)
ON
O
Milk
Poultry ft Eggs
TGAI or Plant
Metabolites
THAI or Plant
Metahollfces
Partially
Yes
I
Yes
Yes
Partially
Partially
Yes
00097313,
00066784, 00097301
00097311
00097308
(IR-4/PP#6El842)
1976
00035614
Yes 7/3V 18 months
No 7/
No 7/
No 7/
Yes T/35/ 18 months
Yes 7/36/ 18 months
00035346, 00097167 No 7/
Partially 00035358, 00035359 Yes 37/ 18 months
00104728
00035358, 00035359 Yes 3_8/ 18 months
00104728
Partially
Partially 00054214, 00097354 Yes 39/ 18 months
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR BENOMYL
§158.125 Residue Chemistry - Continued
I/ Composition: TCAI = Technical grade of the active Ingredient; PAIRA = Pure active ingredient, radlolabelled; TEP =
Typical end-use product; EP = End-use product.
2/ Data must he submitted within the indicated time frame, based on the date of the Guidance Document.
0 15 Month Due Date is April 30, 1987.
0 18 Month Due Date Is July 30. 198T7
3_/ Data depicting the distribution and metabolism of [l^C]Bencmyl are required for the following: a) mature soybeans
harvested 35 days after the last of two foliar applications at 0.5 Ib al/A (applied 1*1 days apart),
b) mature rice (grain and straw) harvested 21 days after the last of two foliar applications at 1.0 Ib ai/A
c) peaches(fruit) harvested Immediately after the last of two foliar applications «3 weeks apart) at 1.0 Ib al/A;
d) sugar beets harvested 21 days after the last of five foliar 4ppllcatlons at .25 Ib ai/A.
If the metabolism data differ significantly between these four, then metabolism data must be submitted for a repre-
sentative crop in each crop group for which registered uses of benomyl exist.
Analyses should Include hydrolysis and reextractlon of plant residues to determine the nature of bound or conjugated
residues of benomyl.
V Data depleting the distribution and metabolism of [l^C]Benomyl are required for the following!
a) Metabolism data utilizing ruminants where animals must be dosed for 3 days with [ll!fi]benomyl at 174 ppn
in the total diet. The animals must be sacrificed within 2*1 hours of the final dose. The distribution and
characterization of residues (free and conjugated) must be determined in the kidney, muscle and fat,
b) Metabolism data utilizing poultry where hens must be dosed for 3 days with [l^Cjbenomyl at 26.0 ppm
In the total diet. The birds must be sacrificed within 24 hours of the final dose (eggs must be collected
twice daily). The distribution and characterization of residues (free and conjugated) must be determined in
the eggs, muscle, fat, kidney and liver.
5_/ A validated data collection and enforcement method is required for detection and quantification of all residues of
concern (bound and free) in ruminant liver. This will require feeding of [ ^CDbenomyl, [^CDMBC, and [1^C]2-AB
(and any additional major plant metabolites of toxlcologlcal concern) to living animals rather than standard
fortification and recovery tests.
6/ The following storage stability data are required:
a) Storage Intervals must be provided for samples used to generate supporting tolerances for residues In or on the
commodities and their processed products listed under CPR 40 § 180.294,
b) Frozen storage stability of benomyl, MBC, and 2-AB in two plant commodities fortified at levels of each ranging
from O.I to 125.0 ppm at Intervals up to 9 months or longer If the storage intervals for the commoflltles listed
O^ In the data gaps above exceed 9 months.
-------
TABLF. A
GENERIC DATA RRQIUREMEWTS TOR BENOMYL
§158.125 Residue Chemistry - Continued
7/ Note: When the required data under sections, "Nature of Residues in Plants", "Residue Analytical Methods", and
"Storage Stability" are reviewed, data for this crop may result In additional data requirements.
8/ Additional carrot residue data are required: data reflecting multiple ground and aerial foliar applications (applied
at 7-day intervals) of the 50% WP formulation at 0.5 lb ai/A application from tests conducted In California (^8.5%),
Texas (13/0, and Wisconsin (958). Samples must he collected 1 days after the final application.
£/ Certain data reflecting residues of benomyl and MBC In or on celery (untrlmned) 7 days after the last of 28 ground
and aerial applications (made at 7-day Intervals) of the 50% WP or 75% PIC formulation at 0.25 lb al/A are
required. Testa should be conducted in California (CA), Florida (FL), and Michigan (MI), states which
represent the major U.S. celery production areas. Samples must be collected 4 days after the final application.
Addltonal celery residue data are required: data reflecting 28 aerial applications (made at 7-day Intervals) of the
10% SC/L and either the 50% WP, 3% FIG, or 75% F1C formulation from tests conducted in CA.
10/ Data reflecting residues of benomyl and MBC in or on dandelion greens per the proposed use of the 50% WP formulation
at 0.25 lb al/A applied 4 times at 7-day intervals are required. Additional data showing the recovery of benomyl
and MBC following storage of fortified samples at Intervals approximating the celery data are required.
ll/ Data reflecting residues of benomyl and MBC in or on spinach per seed treatment at 1.00 lb al/100 lb of seed using
the 50% WP formulation In a slurry from tests conducted in CA, CO, MD, NJ, TX, or VA.
12/ Certain data reflecting residues of benonyl and MBC in or on mature broccoli immediately after the last of three
foliar treatments (applied at Ht-day Intervals) with the 50% WP at 1.00 lb ai/A are required. Both ground and aerial
applications must he represented. Tests should be conducted in Arizona (AZ) and Washington (WA).
13/ Certain data reflecting residues of benomyl and MBC In or on mature cabbage harvested Immediately after the last of
three foliar treatments (applied at Ill-day intervals) with the 50% WP at 1.00 lb al/A are required. Both ground and
aerial applications must be represented. Tests should be conducted In AZ and WA.
IV The Agency will extrapolate residue data required In or on mature broccoli for residue data on cauliflower.
15/ The Agency will extrapolate residue data required in or on mustard greens for residue data on collards and kale.
T6/ The Agency will extrapolate residue data required In or on broccoli and cauliflower for residue data on kohlrabi.
17/ Data from mustard greens harvested at normal maturity Which were seed-treated at H oz al/100 lb seed are required.
The tests should be conducted In WA, which can also represent OR. Additional data are required showing residues
in or on mature mustard greens harvested Immediately after the last of three foliar treatments (applied at iM-day
intervals) with the 50% WP at 1.00 lb al/A. Both ground and aerial applications must be represented. Testa must
be conducted in WA.
ON
ro
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR BENOMYL
S158.125 Residue Chemistry - Continued
18/ A processing study is required depicting a) combined residues for benomyl and MBC in or on soybean hulls; and b)
residues of benomyl (including its conversion products STB and BUB) in refined oil and soapstock.
19/ Certain residue data are required: data reflecting residues in or on bean vine hay harvested 14 days after the last
of two foliar applications (made with aerial and ground equipment) with either the 50% WP or 75% F1C formulation at
1.00 lb ai/A. The first application should be made at 25-50% bloom and the second at peak bloom.
Tests should be conducted in MI, NY, OR and WI, where these states represent the major U.S. growing areas for beans.
A tolerance must be proposed; alternatively, a bean vine hay feeding restriction may be imposed.
2py Certain residue data are required: data reflecting residues in or on bell peppers harvested immediately after the
last of >8 foliar applications of the 50% WP and 10% SC/L formulations at 0.5 lb ai/A. Both ground and aerial
applications must be represented. Tests must be conducted in CA.
21/ An additional processsing study utilizing standard industrial procedures is required using tomatoes containing
measurable weathered residues of benomyl and reflecting analysis of concentrated tomato products and wet and
dry pomace.
22/ The Agency will extrapolate certain residue data utilized for melons to pumpkins and winter squash.
23/ Certain residue data are required: a) Data pertaining to oil processed from field-treated oranges bearing detectable
weathered residues, b) data showing residues in dried pulp processed from whole oranges bearing measurable weathered
residues, and c) data showing residues in or on whole oranges bearing measurable weathered residues and in or on
peel processed from these oranges (alternatively, submit calculation of residues in whole orange fruit in MRID
00040272.
24/ Data are required depicting combined residues for benomyl and MBC in or on prunes (dried) processed from fresh prunes
tearing measurable weathered residues.
25/ The Agency will extrapolate certain residue data utilized for blueberries to currants.
26/ The Agency will extrapolate certain residue data utilized for blackberries, boysenberries, and raspberries to dew-
berries and to loganberries.
27/ Residue data are required from raisin waste, processed from grapes bearing measurable, weathered residues.
28/ Residue data are required from mature strawberries harvested on the day of the last of five aerial and ground appli-
cations (separate tests) with the 1.5% D(dust) formulation, at 0.6 lb ai/A. The applications should be made at
7-day intervals. The tests must be done in CA or OR where D formulations are registered.
29/ Residue data are required reflecting residues in or on fresh sweet corn harvested immediately after the last of _X5
foliar applications of the 50% WP and 10% SC/L formulations at 0.5 lb ai/A. Both ground and aerial application data
must be represented. Tests must be conducted in CA.
30/ Data are required depicting combined residues for benomyl and MBC in or on rice hulls, polished rice, and milled
products processed from rough rice containing measurable weathered residues.
ON
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR BENOMYL
§158.125 Residue Chemistry - Continued
3J7 Residue data are required per Agency memoranda of 10/10/8*1 In file (PP06F1748: Tolerances on Cereal Grains Group):
a. Validated analytical method determining the total toxic residues including bound metabolites or benomyl in
liver,
b. Establishing tolerances of 4 ppn In liver of cattle, goats, hogs, horses, and sheep, and
c. Establishing tolerance of 1 ppm In milk.
3_2/ Residue data are required reflecting residues In or on sweet corn forage and fodder harvested Immediately after the
last of >5 foliar applications of the 50$ WP and 10$ SC/L formulations at 0.5 Ib al/A. Both ground and aerial
application data must be represented. Tests must be conducted In CA.
33/ Hafca are required depleting combined residues for benomyl and MBC In or on rice straw as the result of two folJar
applications (the first made at booting; second at heading) using the 50$ WP and 10$ SC/L formulations at 1.0 Ib
ai/A. Both ground and aerial application data must be represented using a 21-day pre harvest interval (PHI).
Tests must be conducted In AR, LA, MS, or TX.
3V Residue data are required reflecting residues in or on avocados harvested 14 days following the last of 15 appli-
cation of the 75$ PIC formulations at 1.25 Ib ai/A. Both ground and aerial application data must be represented.
Tests must be conducted In PL. I
35_/ Residue data are required reflecting combined residues of benomyl and MBC in or on papayas harvested I'I days after
the last of 7 applications (applied at three week Intervals) of the 50$ WP formulations at 0.5 Ib ai/A.
Both ground and aerial application data must be represented. Tests must be conducted in Hawaii.
36/ Certain residue data are required on pineapples:
a. Data reflecting combined residues of benomyl and MBC in bran prepared from pineapples bearing measurable
weathered residues.
b. Data reflecting combined residues of benomyl and MBC In or on forage grown from seed pieces dipped In 0.625 Ib
ai/100 gallons benomyl prepared with the 50$ WP or 75$ PIC formulations. A tolerance must be proposed or
alternatively, a feeding and grazing restriction may be proposed.
37/ Hie established tolerances for the combined residues of benomyl and MBC (calculated as benomyl) in the fat, meat,
meat by-products of cattle, goats, hogs, horses, and sheep may be revised when the required metabolism studies for
plants and animals are submitted and reviewed.
38/ The established tolerances for the combined residues of benomyl and MBC (calculated as benomyl) In milk may be
revised when the required metabolism studies for plants and animals are submitted and reviewed.
39/ The established tolerances for the combined residues of benomyl and MBC (calculated as benomyl) in the fat, liver,
meat, meat by-products and eggs of poultry may be revised when the required metabolism studies for poultry
are submitted and reviewed.
•5
ON
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR BENOMYL
Data Requirement
I/ Use 21
Composition Pattern
Does F.PA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIPRA § 3(c)(2)(B)?
Time Frame for Data
Submission 3/
§158.130 Environmental Pate
DEGRADATION STUDIES-LAB;
161-1 - Hydrolysis
Photodegradation
161-2 - In water
161-3 - On soil
I6l-l| - In Air
METABOLISM STUDIES-LAB;
162-1 - Aerobic Soil
162-2 - Anaerobic Soil
162-3 - Anaerobic Aquatic
162-lJ - Aerobic Aquatic
MOBILITY STUDIES;
163-1 - Leaching and
Adsorptlon/Desorptlon
163-2 - Volatility (Lab)
163-3 - Volatility (Field)
TCAI or PAIRA A,B,C,E,F,H Yes
TOAI or PAIRA A.B.C
TOAI or PAIRA A
TOAI or PAIRA R,F
TCAI or PAIRA A,B.E,F,H
TQAI or PAIRA A
TOAI or PAIRA C
TQAI or PAIRA C
TKP
TRP
A.E.F1
A.F..F
No
No
No
No
TOAI or PAIRA A,B,C,E,F,H Partially
No
No
Ace. 259^71
Ace. 259*«71
No
Yes
Yes
No 1
Ace. 259^71
Ace. 259^71
No
No
No 9/
Yes 27 months
Yes V5/ 27 months
Yes 27 months
Yes 27 months
Yes 10/ 12 months
Yes
Yes
12 months
15 months
Ox
-------
TABLR A
GENERIC DATA REQUIREMENTS TOR BENOMYL
Data Requirement
Composition
Use 2/
Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
§158.130 Environmental Fate - Continued
DISSIPATION STUDIES-FIELD:
TEP
TEP
TEP
TEP
164-1 - Soil
J64-2 - Aquatic (Sediment)
164-3 - Forestry
164-4 - Combination and
Tank Mixes
164-5 - Soil, r/jng-tenn
ACCUMULATION STUDIES;
165-1 - Rotational Crops
(Confined)
165-2 - Rotational Crops
(Field)
165-3 - Irrigated Crops
165-4 - In Fish
165-5 - In Aquatic Non-Target
Organisms
TEP
A.B.H
C
G
No
No
No
No
No
PAIRA
TEP
TEP
TOAI or PAIRA
TEP
A,C
A.C
C
A,B,C
A,B,C
No
No
No
Mb
No
Must Additional Data
Be Submitted Under
PIFRA § 3(c)(2)(B)7
Time Frame for Data
Submission 3/
Yes 27 months
Yes 27 months
No 9/
No 6/
Yes 50 months
Yes 7/ 39 months
Yes 7/ 50 months
Yes 8/ 39 months
Yes ll/
No 9/
0\
ON
-------
TABLF. A
GENERIC DATA RFQUIRFMEWTS FOR BRNOMYL
§138.130 Environmental Pate - Continued
I/ Composition? TGAI = Technical grade of the active Ingredient; PAIRA = Pure active Ingredient, radlolabelled;
TEP = Typical end-use product.
2/ The jise patterns are coded as follows: A=Terrestrlal, Pood Crop; B=Terrestrlal, Non-Pood; C=Aquatlc, Pood Crop;
D=Aquatlc, Non-Food; E=Greenhouse, Pood Crop; P=Greenhouse, Non-Pood; G=Porestry; H=Domestlc Outdoor; I=Indoor.
3/ Data must be submitted within the indicated time frame, based on the date of the Guidance Document.
0 12 Month Due Date is April 30, 1987.
0 15 Month Due Date is July 30, 19377
0 27 Month Due Date Is July 30, 198B".
0 39 Month Due Date is July 30. 1989.
0 50 Month Due Date is June 30, 1990.
V Data are only required for field-vegetable crop uses.
5/ Anaerobic aquatic metabolism data may be substituted for anaerobic soil metabolism data.
]!>/ Data requirements on Benomyl In combination and tank mixes are not addressed in this Guidance Document.
7/ Por crops rotated on treated areas, one of the following requirements will apply.
a. A tolerance must be obtained for the rotated crop.
b. Data must he submitted to determine a rotational Interval at which unregistered crops planted on treated areas
will be free of Illegal residues.
8/ Por benomyl use on rice, one of the following requirements will apply.
a. A tolerance must be obtained for any crop used for food or feed which is exposed to irrigation water containing
benomyl residues.
b. Data must be submitted to show conditions under which rice irrigation water can be used on other crops without
resulting in illegal plant residues.
9_/ Data are not required In accordance with the current use patterns.
10/ Data are required on the adsorption and desorptlon of benomyl in an aquatic sediment.
ll/ Data on the primary degradate are currently being reviewed by the Agency and they may be acceptable In support
of the Benomyl Registration Standard.
ON
-------
TABLE A
GENERIC DATA RfJQIUREMEWTS FOR BRNOMYL
Does EPA Have Must Additional Data
Data To Satisfy Be Submitted Under
I/ Use 2/ This Require- Bibliographic PIPRA § 3(c)(2)(B)?
Data Requirement Composition Pattern ment? (Yes, No Citation Time Frame for Data
or Partially) Submission 3/
§158.110 Reentry Protection
132-1
133-1
133-3
133-4
§158.H12
201-1
201-1
- Foliar Dissipation TEP A.B.C No
- Soil Dissipation TEP A.B.C No
- Dermal Exposure TEP A.B.O No
- Inhalation Exposure TEP A,B,C No
Spray Drift
- Droplet Size Spectrum TEP A.B.C No 1
- Drift Field Evaluation TEP A,B,C No
No V
No V
No V
No V
No V
No V
I/ Canposition: TEP = Typical end-use product.
2/ '~he use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrlal, Non-Food; C=Aquatlc, Food Crop;
~ D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=0reenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
3/ Data not required based on the current Agency Guidelines.
V These data requirements are not applicable to Benomyl's use patterns.
ON
CO
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR BENOMYL
Does EPA Have
Data To Satisfy
I/ Use 2/ This Require- Bibliographic
Data Requirement Composition Pattern ment? (Yes, No Citation
+^~~ or Partially)
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)7
Time Frame for Data
Submission 3_/
§158.135 Toxicology
ACUTE TESTING:
81-1
fil-2
81-3
81-1
81-5
81-6
81-7
- Acute Oral Toxlcity - Rat
- Acute Dermal Toxlcity
- Rabbit
- Acute Inhalation Toxic Ity
- Rat
- Primary Eye Irritation
- Primary Skin Irritation
- Dermal Sensitlzatlon
- Delayed
Neurotoxlcity - Hen
TCAI
TOAI
TOAI
TOAI
TGAI
TCAI
TGAI
A,B,E,F,G,H
A,B,E,F,G,H
A,B,E,F,G,H
A,B,E,F,G,H
A,B,E,F,G,H
A,B,E,F,G,H
A,B,E,F,G,H
Yes
Yes
Yes
i
1
Yes
Yes
Yes
Yes
00097277
00064822
00097599, 00097281
00061820, 00084579
00061821
00097289
GS01 19-007
No
No
No
No
No
No
No
SUBCHRONIC TESTING:
82-1
82-2
82-3
82-4
- 90-Day Feeding:
- Rodent (Rat),
- Non-rodent (Dog)
- 21-Day Dermal - Rat
- 90-Day Dermal - Rabbit
- 90-Day Inhalation:
TCAI
TGAI
TCAI
TCAI
A,B,E,F,G,H
A,B,E,F,0,H
A,B,E,F,G,H
A,B,E,F,G,H
Yes
Yes
No
No
00066771
00066785
00097287
No
No
No
No V
Yes 15 months
- Rat
\O
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR BENOMYL
Data Requirement
I/ Use 2/
Composition Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
PIPRA § 3(c)(2)(B)?
Time Frame for Data
Submission 2/
§158.135 Toxicology - Continued
SUBCHRONIC TESTING:
82-5 - 90-Day Neurotoxlclty: TGAI
- Hen
-Mammal
CHRONIC TESTING!
83-1 - Chronic Toxlctty -
2 species:
- Rodent, and TGAI
- Non-rodent (Dog) TGAI
83-2 - Oncogenlcity -
2 species:
- Rat (preferred), and TOAI
- Mouse (preferred) TGAI
83-3 - Teratogenlclty -
2 species:
- Rat TOAI
- Mouse TGAI
83-1 - Reproduction - Rat TGAI
2-generatlon
A,B,E,P,G,H
No
A,B,E,F,G,H Yes
A,B,E,P,G,H Yes
A,B,E,F,G,H yes
A,B,E,P,G,H Yes
A,B,E,F,G,H Yes
A,B,E,F,G,H Yes
A,B,E,P,G,H Yes
00097281
00061618, 00081913
00097305, 00097318
00097326
00097281
00096511
00115671, 00126522
GS0119-009,
GS0119-017
00066773
No I/
No
No
No
No
No
No
No
CD
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR BENOMYL
Paid Requirement
I/ Use 2/
Composition Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
OP Partially)
Bibliographic
Citation
l^st Additional Data
Be Submitted Under
PIPRA § 3(c)(2)(B)?
Time Frame For Data
Submission 3/
§158.135 Toxicology - Continued
MUTAGENICITY TESTING
81-2 - Gene MutatIon
TOAI
81-2 - Structural Chromosomal TQAI
Aberration
81-1 - Other Genotoxlc Effects TGAI
A,B,E,P,G,H Yes
A,B,E,P,G,H Yea
A,B,E,P,G,H Yes
00038808, No
OS0119-001, GS0119-002
GS0119-003, GS0119-OOiJ No
GSO119^005, GSO119-006 No
SPECIAL TESTING
85-1 - General Metabolism
85-2 - Dermal Penetration
86-1 - Domestic Animal
Safety
PAI or PAIRA A,B,E,P,0,H No
Choice A,B,E,P,G,H Yes
Choice A,B,E,P,G,H No
OS0119-011
Yes 21 months
No
No I/
-------
TABLE A
GENERIC DATA REQIJIREMEOTS FOR BENOMYL
§158.135 Toxicology - Continued
I/ Composition: PAI = Pure active Ingredient; PAIRA = Pure active Ingredient, radlolahelled; Choice « Choice or
several test substances determined on a case-by-case basis.
2/ The use patterns are coded as follows: A=Terrestrlal. Food Crop; B=Terrestrlal, Non-Pood; C=Aqautlc, Pbod Crop;
D=Aquatic, Non-Food; E=Greenhouse, flood Crop; P=0reenhouse, Non-flood; G=Fbrestry: H=Domestlc Outdoor; I=Indoor.
3/ Data must be submitted within the Indicated time frame, based on the date of the Guidance Document
0 15 Month Due Date Is July 30. 198?.
0 2H Month Due Date Is April 30, 19BB .
V The guidelines and use patterns Indicate that these data are not required.
-------
(34)
TABLE A
GENERIC DATA REQUIREMENTS FOR BENOMYL
— -- ' I/
Data Requirement Composition
§158.145 Wildlife and
Aquatic Organisms
AVIAN AND MAMMALIAN TESTING
71-1 - Acute Avian Oral Toxicity
71-2 - Avian Subacute Dietary
Toxicity
- Upland Game Bird, and
- Waterfowl
71-3 - Wild Mammal Toxicity
71-4 - Avian Reproduction
- Upland Game Bird, and
- Waterfowl
71-5 - Simulated Field Testing
- Mammals, and
- Birds
- Actual Field Testing
„. - Mammals, and
- Bin Is
TGAI
MBC 9/
TGAI
TGAI
MBC 9/
TGAI
TGAI
TGAI
MBC 9/
TEP
TEP
TEP
TEP
use y
Pattern
A,B,C
A,B,C
A,B,C
A,B,C
A,B,C
A,B,C
A,B,C
A,B,C
A,B,C
A,B,C
A,B,C
A,B,C
A,B,C
Does EPA Have
Data To Satisfy
This Require- Bibliographic
ment? (Yes, No Citation
or Partially)
No
No
1
Partially 00066783
Partially 00066783
No
No
No
No
No
No
No
No
No
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Time Frame Eor Data
Submission V
Yes 9 months
Yes 9 months
Yes 5/ 9 months
Reserved 5_/
Yes 9 months
No U/
Reserved 6/
Reserved 6/
Reserved 6/
No U/
No n/
NO n/
No U/
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR BENOMYL
Does EPA Have Must Additional Data
Data To Satisfy Be Submitted Under
I/ Use 2/ This Require- Bibliographic FIFRA § 3(c)(2)(B)?
Data Requirement Composition Pattern ment? (Yes, No Citation Time Frame Cor Data
or Partially) Submission V
§158.145 Wildlife and
Aquatic Organisms - Continued
AQUATIC ORGANISM TESTING
70-1 - Special Test TEP C
(Residue Monitoring)
72-1 - Freshwater Fish Toxicity TGAI
- Warmwater Fish Species, A,B,C
TEP 7/ A,B,C
a) WP 12/ C
b) PC 13/ C
MBC 9/ A,B,C
- Coldwater Fish Species TGAI A,B,C
TEP 8/
a) WP _L2/ C
->l b) FC U/ C
MBC 9/ A,B,C
72-2 - Acute Toxtcity to TCAI
Partially GS0119-033 Yes 10/ 24 months
Yes GSO 119-019, GSO 119-020 No
GS0119-024
No - Yes 9 months
Yes GS0119-019, 00066782 No
GS0119-020, GS0119-022
GS0119-024, GS0119-025
No - Yes 9 months
Yes GSO 119-019 No
Yes GS0119-019, GS0119-020 No
Yes 00070426, 00097615 No
GS0119-019, GS0119-020
GS0119-021, GS0119-023
No No ll/
Yes GS0119-019 No
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR BENOMYL
Data Requirement^
§158.145 Wildlife and
Aquatic Organisms - Continued
Does EPA Have Must Additional Data
Data To Satisfy Be Submitted Under
I/ Use 2/ This Require- Bibliographic FIPRA § 3(c)(2)(B)7
Composition Pattern ment? (Yes, No Citation Time Frame for Data
or Partially) Submission 3/
TEP V C No
a) WP 12/ C No
b) PC JL3/ C No
MBC 9/ A,B,C No
Yes 9 months
Yes 9 months
Yes 9 months
Yes 9 months
72-3 - Acute Toxlclty to
Estuarlne and Marine
Organisms
- Marine Fish
- Mollusk
- Shrimp
72-1 - Fish Early Life Stage,
and
- Aquatic Invertebrate
Life-Cycle
Ul
72-5 - Fish - Life-Cycle
TCAI
TOAI
TCAI
TEP 15/
a) WP 12/
b) PC 13/
MBC 9/
TOAI
TOAI
A,B,C
A.B.C
A.B.C
C
C
C
C
C
C
No
No
No
No
Partially
No
No
No
No
00078579
TCAI
No
Yes 12 months
Yes 12 months
Yes 12 months
Yes 12 months
Yes 16/ 12 months
Yes 12 months
Yes 15/ 12 months
Yes V 15 months
Yes 15 months
Reserved 8/
-------
TABLE A
O.RNERIC DATA RRQUIRFMENTS FOR BENOMYL
Data Requirement
Composition
I/
Use
Pattern
Does WA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
PIPRA § 3(c)(?)(B)7
Time Frane Tor Data
Submission ?/.
Wildlife anrl
Aq'uatlc Organisms - Continued
72-6 - Aquatic Organism
Accumulation
- Crustacean
- Pish
- Insect Nymph
- Mollusk
72-7 - Actual Field Testing
-Aquatic Organisms
TOAT, PAI OR
Degradation
Product
TRP
No
No
No
No
No
No IV
No IV
No 1±/
No IV
Reserved 17/
o\
-------
TABLR A
GENERIC DATA REQUIREMENTS TOR BENOMYL
§158.115 Wildlife and Aquatic Organisms - Continued
I/ Composition: TOAI = Technical grade of the active ingredient; PAI » pure active Ingredient;
TEP = Typical end-use product;
21 The use patterns are coded as follows: A=Terrestrlal, Food Crop; B=Terrestrlal, Non-Pood Crop; C=Aquatlc, Food Crop;
D=Aquatlc, Non-FVxxi; E=Greenhouse, Fbod Crop; F=Greenhouse, Non-Fbod; G=Worestry; H=Domestlc Outdoor; I=Tnd
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR PFNOMYL
Data Requirement
I/ Use 2/
Composition Pattern
"Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
§158.155 Nontarget Insect
NONTAROET INSECT TESTING) -
POLLINATORS;
l'11-l - Honey bee acute
contact toxlclty
1*11-2 - Honey bee - toxlclty
or residues on
foliage
-*! - Honey bee subacute
feeding study
1*11-5 - Field testing for
pollinators
NONTARQET INSECT TESTINO -
AQUATIC INSECTS;
1*12-1 - Acute toxlclty to
aquatic Insects
112-1 - Aquatic Insect
life-cycle study
1*12-3 - Simulated or actual
field testing for
aquatic Insects
l'13-l - NONTARGET INSECT
thru TRSTINO - PREDATORS
1H3-3 AND PARASITES
TOAI
TEP
(Reserved) V
(Reserved) 6/
(Reserved) 6/
(Reserved) 6/
(Reserved) 6/
A,B,0,H
A,B,0,H
A.B.H.H
Yes
Yes
No
05001991
00077760
~l*ist" AdillhiohWV TVita"
Be Submitted Mndor
Time Frame Tor Data
Submission 3/.
No
No
No 5/
GO
-------
TABLE A
GRNRRin DATA RRQIJIRFNEOTS FDR BRNOM*!,
§158.135 Nontarget Insects
I/ Composition: TOAI s Technical grade of the active ingredient; TEP = "typical end-use product.
?./ The use patterns are coded as follows: A=Terrestrlal, Fbod Crop; B=Terrestrlal, Non-Fbod; C=»Aquatlc, Pood Crop:
D=Aquatlc, Non-Pood; E=Greenhouse, Pood Crop; P=Greenhouse, Non-Pood; 0=Porestry; H=Domestlc Outdoor; I=Tndoor.
3/ Currently no data are required.
V Reserved pending development of test methodology.
5/ As lower-tier tests show benomyl to be relatively non-toxic to honey bees, no further testing is required.
&7 Reserved pending Agencysf decision as to whether data requirement should be established.
SO
-------
TABLK B
PRODIKTT SPECIFIC DATA REQUIREMENTS TOR MANUFACTURINO.-USE PRODUCTS CONTAINING BENOMYL
Guideline Citation and
Nam* of Test
§158.120 Product Chemistry
Product Identity:
61-1 - Product Identity and Disclosure
of Ingredient
61-2 - Description of Beginning Materials
and Manufacturing Process
61-3 - Discussion of formation of
Impurities
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
62-2 - Certification of Lunlts
62-3 - Analytical Method for Enforcement
of Limits
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical State
63-'l - Odor
63-5 - Melting Point
63-6 - Ho lUng Point
Test Guidelines Are Data
Substanoel/ Status2/ Required
Yes No
TOAI
TOAI
TOAI
TGAI
TOAI
TOAI
TOAI
TOAI
TOAI
TOAI
WAI
R .
R
R
CR
CR
CR
R
R
R
R
R
O
CS
Q
|
o
m
LX]
n
n
n
n
n
TO
O
[X]
[X]
n
G
m
m
m
m
CX]
Data Must Be
footnote Submitted Wlhhtn
Number or Time Frames Listed
Citation Below3/
00067U16, 00067121
-
00151522
00151523
/
00151523 6/
(Partially)
00067121. 00151521
00151521
00151521
00151521
V
6 months
12 months
12 months
oo
o
-------
TABLF B
PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS COffPATNING BENOMYf,
Guideline Citation and
Name of Test
Teat Guidelines
Suhatancel/ Status2/
Are Data
Required
Yes No
footnote
Number
Product Chemistry (Continued)
Physical and Chemical Characteristics
^Continued)
63-7 - Density, Bulk Density, or
Specific Gravity
TGAI
CX]
00151521
Data" Wist"Be "
Submitted Within
Time Frames Listed
BelowB/
63-8
63-9
63-10
63-11
63-12
63-13
Other
61- 1
- Solubility
- Vapor Pressure
- Dissociation constant
- Octanol/water partition
coefficient
- pH
- Stability
Requirements :
- Submlttal of samples
TGAI or PAI
PAI
PAI
PAI
TGAI
TGAI
TGAI, PAI
R
R
R
R
R
R
CR
n
CX}
O
o
CX)
o
o
[x] 00151521
O
[X] 00151521
[X] 00151521
O
CD
[Xl 5
6 months
6 months
]J TGAI = Technical Grade of the Active Ingredient; PAI = Pure Active Ingredient.
21 R = Required: CR * Conditionally Required.
3/ Data must be submitted within the Indicated time frame, based on the date of the Guidance Document.
6 Month Due Date Is October 30, 1986.
12 Month Due Date Is April 30. 1987.
V This Is not required for benomyl since It Is a solid.
5/ This compound does not require the suhmlttal of samples at this time.
6/ Information Is required on the detector utilized In the gas chromatographlc procedure for determining 1,3-dlbutyl urea
OOln technical, benomyl.
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS CONTAINING BENOMYF,
Data Requirement
Does EPA Have
Data To Satisfy
V This Requlre-
Composltlon ment? (Yes, No
or Partially)
Must Add
Be Subml
Bibliographic FIFRA §
Citation Time Fra
Submlssl
§158.135 Toxicology
; ACUTE TESTING
81-1
81-2
8 1-3
81-1
81-5
81-6
81-7
- Acute Oral Toxlclty - Rat
- Acute Dermal Toxlcity
- Rabbit
- Acute Inhalation Toxlclty
- Rat
- Primary F,ye Irritation
- Primary Skin Irritation
- Dermal Sensltlzatlon
- Delayed
MP
MP
MP
MP
MP
MP
MP
A,B,E,F,0,H
A,B,E.F,G,H
A,B,E,F,G.H
A,B,E,F,0,H
A,B,E,F,0,H
A,B,E,P,0,H
A,B,E,F,0,H
Yes
Yes
Yes
1
Yes
Yes
Yes
Yes
00097277
00061822
00097599, 00097281
00061820, 00081579
00061821
00097289
GS0119-007
No
No
No
No
No
No
No
Neurotoxlclty - Hen
I/ Composition: MP = Manufacturing-use product.
2/ Additional data are not required by the Agency.
OO
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II. LABELING APPENDICES
40 CFR 162.10 Labeling Requirements
Physical/Chemical Hazards Labeling Statements
Storage Instructions
Pesticide Disposal Instructions
Container Disposal Instructions *'
83
-------
SUMMARY-1
LABEL CONTENTS
40 CFR 162.10 requires that certain specific labeling
statements appear at certain locations on the label. This
is referred to as format labeling. Specific label items listed
below are keyed to the table at the end of this Appendix.
Item 1. PRODUCT NAME - The name, brand or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading.
Item 2. COMPANY NAME AND ADDRESS - The name and address
of the registrant or distributor is required on the label.
The name and address should preferably be located at the
bottom of the front panel or at the end of the label text.
Item 3. NET CONTENTS - A net contents statement is
required on all labels or on the container of the pesticide.
The preferred location is the bottom of the front panel
immediately above the company name and address, or at the end
of the label text. The net contents must be expressed in the
largest suitable unit, e.g., "1 pound 10 ounces" rather than
"26 ounces." In addition to English units, net contents may
be expressed in metric units. [40 CFR 162.10(d)l
Item 4. EPA REGISTRATION NUMBER - The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase "EPA Registration No.," or "EPA
Reg. No." The registration number must be set in type of a
size and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
registration number and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency.
[40 CFR 162.10(e)]
Item 5. EPA ESTABLISHMENT NUMBER - The EPA establishment
number, preceded by the phrase "EPA Est." is the final estab-
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment number on the immediate
container cannot be clearly read through such wrapper or container.
[40 CFR 162.10(f)]
Item 6A. INGREDIENTS STATEMENT - An ingredients statement
is required on the front panel. The ingredients statement must
contain the name and percentage by weight of each active ingredient
and the total percentage by weight of all inert ingredients.
The preferred location is immediately below the product name.
The ingredients statement must run parallel with, and be clearly
distinguished from, other text on the panel. It must not be
placed in the body of other text. [40 CFR 162.10(g)]
84
-------
SUMMARY-2
Item 6B. POUNDS PER GALLON STATEMENT - For liquid agricul-
tural formulations, the pounds per gallon of active ingredient
must be indicated on the label.
Item 7- FRONT LABEL PRECAUTIONARY STATEMENTS - Front panel
precautionary statements must be grouped together, preferably
within a block outline. The table below shows the minimum type
size requirements for various size labels.
Size of Label Signal Word "Keep Out of Reach
on Front Panel Minimum Type Size of Children"
in Square Inches All Capitals Minimum Type Size
5 and under 6 point 6 point
above 5 to 10 10 point 6 point
above 10 to 15 12 point 8 point
above 15 to 30 14 point 10 point
over 30 18 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT - The statement
"Keep Out of Reach of Children" must be located on the front
panel above the signal word except where contact with children
during distribution or use is unlikely. [40 CFR 162.10(h)(1)(ii)]
Item 7B. SIGNAL WORD - The signal word (DANGER, WARNING,
or CAUTION) is required on the front panel immediately below
the child hazard warning statement. [40 CFR 162.10 (h)(l)(i)l
Item 7C. SKULL & CROSSBONES AND WORD "POISON" - On products
assigned a toxicity Category I on the basis of oral, dermal,
or inhalation toxicity. the word "Poison" shall appear on the
label in red on a background of distinctly contrasting color and
the skull and crossbones shall appear in immediate proximity to
the word POISON. [40 CFR 162.10(h)(1)(1)1
Item 7D. STATEMENT OF PRACTICAL TREATMENT - A statement
of practical treatment (first aid or other) shall appear on
the label of pesticide products in toxicity Categories I,
II, and III. [40 CFR 162.10(h)(1)(iii)]
Item 7E. REFERRAL STATEMENT - The statement "See Side
(or Back) Panel for Additional Precautionary Statements" is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
[40 CFR 162.lO(h)(l)(iii)]
Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING - The
precautionary statements listed below must appear together
on the label under the heading "PRECAUTIONARY STATEMENTS."
The preferred location is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline. Each
of the three hazard warning statements must be headed by the
appropriate hazard title. [40 CFR 162.10(h)(2)] . n r
-------
SUMMARY-3
Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS - Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions to be taken to avoid
accident, injury or damage. [40 CFR 162.10(h)(2)(i)]
Item 8B. ENVIRONMENTAL HAZARD - Where a hazard exists to
non-target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage. [40 CFR 162.10(h)(2)(ii)]
•^
Item 8C. PHYSICAL OR CHEMICAL HAZARD - FLAMMABILITY
Precautionary statements relating to flammability of a product
are required to appear on the label if it meets the criteria
in the PHYS/CHEM Labeling Appendix. The requirement is
based on the results of the flashpoint determinations and
flame extension tests required to be submitted for all products.
These statements are to be located in the side/back panel
precautionary statements section, preceded by the heading
"Physical/Chemical Hazards." Note that no signal word is
used in conjunction with the f-laramability statements.
Item 9A. RESTRICTED USE CLASSIFICATION - FIFRA sec. 3(d)
requires that all pesticide formulations/uses be classified
for either general or restricted use. Products classified
for restricted use may be limited to use by certified applicators
or persons under their direct supervision (or may be subject
to other restrictions that may be imposed by regulation).
In the Registration Standard, the Agency has (1) indicated
certain formulations/uses are to be restricted (Section III
indicates why the product has been classified for restricted
use); or (2) reserved any classification decision until
appropriate data are submitted.
The Regulatory Position and Rationale states whether
products containing this active ingredient are classified
for restricted use. If they are restricted the draft label(s)
submitted to the Agency as part of your application must
reflect this determination (see below).
If you do not believe that your product should be classified
for restricted use, you must submit any information and
rationale with your application for reregistration. During
the Agency's review of your application, your proposed classi-
fication determination will be evaluated in accordance with
the provisions of 40 CFR 162.11(c). You will be notified of
the Agency's classification decision.
86
-------
SUMMARY-4
Classification Labeling Requirements
If your product has been classified for restricted use,
the following label requirements apply:
1. All uses restricted.
a. The statement "Restricted Use Pesticide" must
appear at the top of the front panel of the label. The
statement must be set in type of the same minimum size
as required for human hazard signal word (see table in 40
CFR 162.10(h)(l)(iv)
b. Directly below this statement on the front panel,
a summary statement of the terras of restriction must
appear (including the reasons for restriction if specified
in Section I). If use is restricted to certified applicators,
the following statement is required: "For retail sale
to and use only by Certified Applicators or persons
under their direct supervision and only for those uses
covered by the Certified Applicator's Certification."
2. Some but not all uses restricted. If the Regulatory
Position and Rationale states that some uses are classified
for restricted use, and some are unclassified, several courses
of action are available:
t
a. You may label the product for Restricted use.
If you do so, you may include on the label uses that
are unrestricted, but you may not distinguish them
on the label as being unrestricted.
b. You may delete all restricted uses from your
label and submit draft labeling bearing only unrestricted
uses.
c. You may "split" your registration, i.e., register
two separate products with identical formulations, one
bearing only unrestricted uses, and the other bearing
restricted uses. To do so, submit two applications for
reregistration, each containing all forms and necessary
labels. Both applications should be submitted simul-
taneously. Note that the products will be assigned
separate registration numbers.
Item 9B [There is no Item 9B].
Item 9C. MISUSE STATEMENT - All products must bear the
misuse statement, "It is a violation of Federal law to use
this product in a manner inconsistent with its labeling."
This statement appears at the beginning of the directions
for use, directly beneath the heading of that section.
87
-------
SUMMARY-5
Item 10A. REENTRY STATEMENT - If a reentry interval
has been established by the Agency, it must be included on
the label. Additional worker protection statements may be
required in accordance with PR Notice 83-2, March 29, 1983.
Item 10B [There is no Item 10B] .
Item IOC. STORAGE AND DISPOSAL BLOCK - All labels are
required to bear storage and disposal statements. These
statements are developed for specific containers, sizes, and
chemical content. These instructions must be grouped and
appear under the heading "Storage and Disposal" in the directions
for use. This heading must be set in the same type sizes as
required for the child hazard warning. Refer to Appendix II,
STOR, PEST/DIS, and CONT/DIS to determine the storage and
disposal instructions appropriate for your products.
Item 10D. DIRECTIONS FOR USE - Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. When followed, directions must be adequate to
protect the public from fraud-and from personal injury and to
prevent unreasonable adverse effects on the environment.
[40 CFR 162.10]
COLLATERAL LABELING
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, or other written or graphic printed matter which is
referred to on the label or which is to accompany the product
are termed collateral labeling. Such labeling may not bear
claims or representations that differ in substance from those
accepted in connection with registration of the product. It
should be made part of the response to this notice and submitted
for review.
-------
SUMMARY-6
LABELING REQUIREMENTS OP THE FIFRA, AS AMENDED
ITEM
1
2
3
4
5
6A
en
7
7A
~7B
LABEL ELEMENT
PL ex loot name
Comjiany name
and address
Net contents
EPA ttetj. No.
EPA Est. No.
Ingredients
statement
Pounds/gallon
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where dosage
given as Ibs.
ai/unit area
All products
All products
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
None
None
4
None
None
I
Front panel
Front panel
Front panel
Front panel
Front panel
PREFERRED
Center front
panel
Bottom front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel,
immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the main
ingredients
statement
Above signal
word
Immediately
below child
hazard
warning
COMMENTS
If registrant is not the producer, must
be qualified by "Packed for . . .,"
"Distributed by. . .," etc.
May be in metric units in addition to
U.S. units
Must 1x9 in similar type size and run
parallel to other type.
May appear on the container instead of
the label.
Text must run parallel with other text
on the panel.
t.
All front panel precautionary statanents
must be grouped together, preferably
blocked .
Note type size requirements.
Note type size requirements.
CO
-------
SUMMARY-7
ITEM
7C
7D
7R
8
8A
8R
IABEL ELEMENT
Skill 1 & CL oss-
bones and word
POISON ( in Led)
Statement of
practical
treatment
Ref erra I
statement
Side/hack panel
precautionary
statements
Hazards to
humans and
dnn»stic
animals
Rnvi ronmental
hazards
APPLICABILITY
OF REQUIREMENT
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxicity
All products
in Categories
I, II, and III
All products
where pre-
cautionary
labeling
appears on
other than
front panel.
All products
All products
in Categories
I, II, and III
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
Category I:
Front panel
unless refer-
ral statement
is used.
Others i
Grouped with
side panel
precautionary
statements.
Front panel
None
None
None
PREFERRED
Both in close
proximity to
signal word
Front panel
for all.
•
Top or side
of back panel
preceding
directions
for use
Same as above
Same as above
COMMENTS
Must be grouped under the headings in
8A, 8B, and 8C; preferably blocked.
Must be preceded by appropriate signal
word.
Environmental hazards include bee
caution where applicable.
-------
SUMMARY-8
ITEM
8C
9A
9C
IDA
IOC
~lo»
IABEL ELEMENT
Physical or
chemical
hazau1s
Restricted
block
Misuse
statement
Reentry
statement
Storage ami
disposal block
Directions
for use
APPLICABILITY
OF REQUIREMENT
All pressurized
products, others
with flash
points under
150°F
All restricted
products
All products
All
chol inesterase
inhibitors
All products
All products
PLACEMENT ON LABEL
REQUIRED
None
Top center
of front
panel
Immediately
following
heading of
directions
for use
In the
directions
for use
In the 1
directions
for use
None
PREFERRED
Same as above
Preferably
blocked
Immediately
after misuse
statement
Immediately
before
specific
directions
for use or
at the end of
directions
for use
None
COMMENTS
Includes a statement of the teuns of
restriction. The words "RESTRIcrRD USE
PESTICIDE" must be same type size as
signal word.
Must be set apart and clearly distin-
guishable from from other directions
for use.
'.
May be in metric as well as U.S. units
-------
Criteria
I. pressurized Containers
A. Flashpoint at or below
20°F; or if there is a
flashback at any valve
opening.
PHYS/CHEM-1
PHYSICAL/CHEMICAL HAZARDS
Required Label Statement
B. Flashpoint above 20°F
and not over 80°F; or
if the flame extension
is more than 18 inches
long at a distance of
6 inches from the
valve opening. —
C. All Other Pressurized
Containers
II. Non-Pressurized Containers
A. Flashpoint at or below
20°F.
B. Flashpoint above 20°F
and not over 80°F-
C. Flashpoint over 80°F
and not over 150°F-
D. Flashpoint above
150°F.
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame. Do
not puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
92
-------
STOR-1
STORAGE INSTRUCTIONS FOR PESTICIDES
Heading;
All products are required to bear specific label instructions
about storage and disposal. Storage and disposal instructions
must be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need not include the heading
"STORAGE AND DISPOSAL." ,
Storage Instructions;
v
All product labels are required to have appropriate storage
instructions. Specific storage instructions are not prescribed.
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors:
1. Conditions of storage that might alter the composition or
usefulness of the pesticide. Examples could be temperature
extremes, excessive moisture or humidity, heat, sunlight,
friction, or contaminating—substances or media.
2. Physical requirements of storage which might adversely
affect the container of the product and its ability to
continue to function properly. Requirements might include
positioning of the container in storage, storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
3. Specifications for handling the pesticide container,
including movement of container within the storage area,
proper opening and closing procedures (particularly for
opened containers), and measures to minimize exposure
while opening or closing container.
4, Instructions on what to do if the container is damaged in
any way. or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs
5. General precautions concerning locked storage, storage in
original container only, and separation of pesticides
during storage to prevent cross-contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original container and placement in
locked storage areas.
93
-------
PEST/DIS-1
PESTICIDE DISPOSAL INSTRUCTIONS
jr
The label of all products, except those intended solely for domestic
use, nust bear explicit instructions about pesticide disposal. The
statements listed below contain the exact wording that must appear on
the label of these products:
1. The labels of all products, except domestic use, must contain the
statement, "Do not contaminate water, food, or feed by storage or'disposal.'
2. Except those products intended solely for domestic use, the labels
of all products that contain active ingredients that are Acute Hazardous
Wastes (see list in this Appendix) or are assigned to Toxicity Category
I on the basis of oral or dermal toxicity, skin or eye irritation potential,
or Toxicity Category I or II on the basis of acute inhalation toxicity
nust bear the following pesticide disposal statement:
•pesticide wastes are acutely hazardous. Improper disposal of
excess pesticide, spray mixture, or rinsate is a violation of Federal
Law. if these wastes cannot be disposed of by use according to
label instructions, contact your State Pesticide or Environmental
Control Agency, or the Hazardous-Haste representative at the nearest
EPA Regional Office for guidance."
3. The labels of all products, except those intended for domestic use,
containing active or inert ingredients that are Toxic Hazardous Hastes
(see list in this Appendix) or meet any of the criteria in 40 CFR 261,
Subpart C for a hazardous waste must bear the following pesticide disposal
statement:
•pesticide wastes are toxic. Improper disposal of excess pesticide,
spray mixture, or rinsate is a violation of Federal Law. if these
wastes cannot be disposed of by use according to label instructions,
contact your State pesticide or Environmental Control Agency, or the
Hazardous Waste representative at the nearest EPA Regional Office
for guidance."
4. Labels for all other products, except those intended for domestic
use, must bear the following pesticide disposal statement:
"Wastes resulting frcm the use of this product may be disposed of on
site or at an approved waste disposal facility."
5. Products intended for domestic use only must bear the following
disposal statement: "Securely wrap original container in several layers
of newspaper and discard in trash."
94
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PEST/DIS-2
PESTICIDE ACTIVE INGREDIENTS THAT ARE ACJTE HAZARDOUS WASTES
I. PESTICIDES OR THE "S* LIST
[40 CFR 261.33(e)J
(with RCRA * and CAS #
Acrolein
Aldicarb
Aldrin
Allyl alcohol
Aluminum phosphide
4-Aminopyridine (Avitrol)
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p-Chloroaniline
Cyanides (soluble cyanide salts
not otherwise specified)
Cyanogen chloride
Dieldrin
0,0-Diethyl S-[2-ethylthio)ethyl]
phosphorodithioate (disulfoton)
0,0-Diethyl 0-pyrazinyl
phosphorothioate (Zinophos9)
Diroethoate
O,O-Dinethyl 0-p-nitrophenyl
phosphorothioate (methyl parathion)
4,6-Dinitro-o-cresol and salts
4,6-Dinitro-o-cyclohexylphenol
Dinoseb
Endosulfan
Endothall
Endrin
Famphur
Fluoroacetamide
Heptachlor
Hexachlorohexahydro-exo,exo-
dimethanonaphtnalene (Isodrin)
Hydrocyanic acid
Methonyl
alpha-Naphthylthiourea (ANTU)
Nicotine and salts
Octame thylpyrophosphoramide
(OMPAr schradan)
Parathion
Phenylmercuric acetate (PMA)
Phorate
Potassium cyanide
Propargyl alcohol
Sodinn azide
Sodium cyanide
Sodium fluoroacetate
POOS
P070
P004
POOS
P006
POOS
P010
P011
P012
P021
P022
P024
P030
P031
P037
-P039
P040
107-13-1
116-06-3
309-00-2
107-18-6
1302-45-0
504-24-5
7778-39-4
1303-28-2
1327-53-3
592-01-8
75-15-0
106-47-8
506-77-4
60-57-1
298-04-4
297-97-2
P044
P071
P047
P034
P020
P050
P088
P051
P097
P057
P059
P069
P063
P066
P072
P075
P085
P089
P092
P094
P098
P102
P105
P106
P058
60-51-5
298-00-0
534-52-1
131-89-5
88-85-7
115-29-7
129-67-9
72-20-8
52-85-7
640-19-7
76-48-8
465-73-6
74-90-8
16752-77-5
86-88-41
54-11-5
152-16-9
56-38-2
62-38-4
298-02-2
151-50-8
107-19-7
26628-22-8
143-33-9
62-74-3
95
-------
PEST/DIS-3
Strychnine and salts P108 57-24-9
60-41-3
0,0,0,0-Tetraethyl P109 3689-24-5
dithiopyrophosphate (sulfotepp)
Tetraethyl pyrophosphate Pill 107-49-3
Thallium sulfate P115 7446-18-6
Thiofanox P045 39196-18-4
Toxaphene P123 8001-35-2
Warfarin (>0.3%) P001 81-81-2
Zinc phosphide (>10%) P122 1314-84-7
50 ACTIVES
F027
F027
F027
P027
P027
5324-22-1
35109-57-0
136-25-4
327-98-0
70-30-4
II. PESTICIDES DERIVED FRCM TRI-, TETRA-, AND PENTACHLOROPHENOLS
[40 CFR 261.31]
2-Chloroethyl 2-( 2,4,6-trichloro-
phenoxy) ethyl ether
Dehydroabietylanmonium
pentachlorophenoxide
Ertxxi
O-ethyl (M2,4,5-trichlorophenyl)
ethylphosphonothioate
2,2'-Methylenebis
(3 f4,6-trichloropheriol)
(Hexachlorophene)
—Potassium salt of
—Sodium salt of
—Disodium salt of
Pentachlorophenol
—Potassium salt of
—Sodium salt of
—Zinc salt of
—Zinc salt of N-alkyl
(Cig-C^s )-l»3-propanediamine
—Pentachlorophenyl laurate
Potassium trichlorophenate (2,4,6)
Potassium trichlorophenate (2,4,5)
Silvex
—2-Butoxyethyl ester
—Butoxypolypropoxypropyl ester
—Sutoxypropyl ester
—Diethanolamine salt
—Diisopropanolamine salt
—Dimethylamine salt
—Dipropylene glycol isobutyl
ether ester
—Sthanolamine salt
—2-Sthylhexyl ester
—Isooctyl ester
F027
F027
P027
F027
F027
P027
F027
P027
F027
F027
F027
F027
F027
F027
F027
P027
F027
F027
F027
F027
F027
F027
67923-62-0
3247-34-5
5736-15-2
87-86-5
7778-73-6
131-52-2
2917-32-0
3772-94-9
2591-21-1
35471-43-3
93-72-1
19398-13-1
53404-07-2
25537-26-2
51170-59-3
53404-09-4
55617-85-1
53535-26-5
7374-47-2
53404-76-5
53404-14-1
96
-------
PEST/DIS-4
—Isopropanolamine salt F027 53404-13-0
—Jtonohydroxylaluminum salt F027 69622-82-8
—Polypropoxypropyl ester F027 83562-66-7
—Potassium salt F027 2818-16-8
—Propylene glycol isobutyl P027 53466-84-5
ether ester
—Sodium salt F027 37913-89-6
—Triethanolamine salt F027 17369-89-0
—Triethylaraine salt F027 53404-74-3
—Triisopropanolamine salt F027 53404-75-4
—Tripropylene glycol isobutyl F027 53535-30-1
ether ester
Sodium 2-(2,4,5-trichlorophenoxy) F027 3570-61-4
ethyl sulfate
Tetrachlorophenols F027 25167-83-3
—Alkylamine*anine salt (as in P027
fatty acids of coconut oil)
—Potassium salt F027 53535-27-6
—Sodium salt F027 25567-55-9
2,4,5-Trichlorophenol P027 95-95-4
2,4,6-Trichlorophenol F027 88-06-2
2,4,5-Trichlorophenol salt of P027 53404-83-4
2,6-bis [ (diraethylamino)methyl]
cyclohexanone
2,4,5-Trichlorophenol, sodium salt F027 136-32-3
2,4,6-Trichlorophenol, sodium salt P027 3784-03-0
2,4,5-Trichlorophenoxyacetic acid EX)27 93-79-8
—Alkyl C-12 amine salt F027 53404-84-5
—Alkyl C-13 anine salt F027 53404-85-6
—Alkyl C-14 amine salt F027 53535-37-8
—N,N-diethylethanolamine salt F027 53404-86-7
—Dimethylamine salt P027 6369-97-7
l,N-dimethyllinoleylamine salt F027 53404-88-9
l,N-dimethyloleylamine salt P027 53404-89-0
—N-oleyl-l,3-propylene F027 53404-87-8
diamine salt
—Sodium salt F027 13560-99-1
—Triethanolamine salt F027 3813-14-7
—Triethylanine salt F027 2008-46-0
—Alkyl (C3H7 - C7H9) ester F027
—Anyl ester F027 120-39-8
—Butoxyethoxypropyl ester F027 1928-58-1
~2-3utoxyethyl ester F027 2545-59-7
—Butoxypropyl ester F027 1928-48-9
—3utyl ester F027 93-79-8
—Dipropylene glycol isobutyl F027 53535-31-2
ether ester
—2-Ethylhexyl ester F027 1928-47-3
—Isobutyl ester F027 4938-72-1
97
-------
PEST/DIS-5
—Isopropyl ester P027 93-78-7
—Propylene glycol isobutyl F027 53466-86-7
ether ester
—Tripropylene glycol isobutyl F027 53535-32-3
ether ester
4-(2,4,5-Trichlorophenoxy)butyric F027 93-80-1
acid [2,4,5-TB]
2-(2,4,5-Trichlorophenoxy)ethyl F027 69633-04-1
hydrogen sulfate [2,4,5-TES]
-/
l,4',51-Trichloro-2l-(2,4,5- F027 69462-14-2
trichlorophenoxy)
roethanesulfonanilide [Edolan U]
98
-------
PEST/DIS-6
PESTICIDES THAT ARE TOXIC HAZARDOUS WASTES
PESTICIDES ON THE "F* LIST (with RCSA «, and CAS t
[40 CFR 261.33(f)J
Acetone U002 67-64-1
Acrylonitrile* U009 107-13-1
Amitrole U011 61-82-5
Benzene* U019 71-43-2
Bis(2-ethylhejQrl) phthalate U028 117-81-7
Cacodylic acid U136 75-60-5
Carton tetrachloride* U211 -• 56-23-5
Chloral (hydrate) U034 302-17-0
(chloroacetaldehyde)
Chlordane, technical* U036 57-74-9
Chlorobenzene* U037 108-90-7
4-Chloro-m-cresol U039 59-50-7
Chloroform* U044 67-66-3
o-Chlorophenol U048 95-57-8
Creosote U051 8021-39-4
Cresylic acid (cresols)* U052 1319-77-3
Cyclohexane — U056 110-82-7
Cyclohexanone U057 108-94-1
Decachlorooctahydro-l,3,4-metheno- U142 143-50-0
2H-cyclobuta[c ,d]-pentalen-2-one
(Kepone, chlordecone)
l,2-Dibrcno-3-chloropropane (DBCP)
Dibutyl phthalate
S-2,3-(Dichloroallyl di isopropyl-
thiccarbamate) (diallate,Avadex)
o-Dichlorobenzene*
p-DiChlorobenzene*
Dichlorodifluoronethane
(Freon 12«)
3,5-Dichloro-N-(l,l-<3iinethyl-2- U192 23950-58-5
propynyl) benzamide
(pronamide, Kerb*)
Dichloro diphenyl dichloroethane U060 72-54-8
(ODD)
Dichloro diphenyl trichloroethane U061 50-29-3
(DDT)
Dichloroethyl ether U025 1191-17-9
2,4-Dichlorophenoxyacetic, U240 94-75-7
salts and esters (2,4-D)*
1,2-Dichioropropane U083 8003-19-8
1,3-Dichloropropene (Telone) U084 542-75-6
Dimethyl phthalate U102 131-11-3
Epichlorohydrin . U041 106-89-8
(1-chloro- 2,3-epoxy propane}
Ethyl acetate U112 141-78-6
Ethyl 4,4'^iichlorobenzilate U038 510-15-6
(chlorobenzilate)
U066
U069
U062
U070
U072
U075
96-12-8
84-74-2
2303-16-4
95-50-1
106-46-7
75-71-8
"Proposed for deletion by TCL? proposal
99
-------
PEST/DIS-7
Ethylene dibromide (ECB)
Ethylene dichloride*
Ethylene oxide
Formaldehyde
Furfural
Hexachlorobenzene*
Hexachlorocyclopentadiene
Hexachloroethane*
Hydrofluoric acid
Isobutyl alcohol*
Lead acetate
Lindane*
Maleic hydrazide
Mercury
Methoxychlor*
Methyl alcohol (roethanol)
Methyl bromide
Methyl chloride
2,2" -He thylenebis
(314,6-trichlorophenol)
(hexachlorophene)
[acute waste per 261.31]
Metnylene chloride*
Methyl ethyl ketone*
4-Methyl-2-pentanone
(methyl isobutyl ketone)
Naphthalene
Nitrobenzene*
p-Nitrophenol
Pentachloroethane
Pentachloronitrobenzene (PCNB)
Pentachlorophenol*
[acute waste per 261.31]
Phenol*
Pyridine*
Resorcinol
Safrole
Selenium disulf ide
Silvex [acute waste per 261.31]
1,1,2,2-Tetrachloroethane*
Tfetrachloroethylene*
2,3,4,6-Tetrachlorophenol*
[acute waste per 261.31]
Thiran
Toluene*
1,1,1-Trichioreethane*
(•ethyl chloroform)
Irichloroethylene*
IrichlcconoiKjfluorcne thane
U067
U077
U115
U122
U125
U127
U130
U131
U134
U140
U144
U129
U148
U151
U247
U154
U029
U045
U132
106-93-4
107-06-2
75-21-8
50-00-0
98-01-1
118-74-1
77-47-4
67-72-1
7664-39-3
78-83-1
301-04-2
58-89-9
123-33-1
7439-97-6
72-43-5
67-56-1
74-83-9
74-87-3
70-30-4
(Freon
2,4,5-Trichlor3phenol*
[acute waste"per 261.31]
2,4,6-TrichicCTphenol*
[acute waste* per 261.311
0080
0159
0161
0165
0169
0170
0184
0185
0242
0188
0196
0201
0203
0205
0233
0209
0210
0212
0244
0220
0226
0228
0121
0230
0231
75-09-2
78-93-3
108-10-1
91-20-3
98-95-3
100-02-7
76-01-7
82-68-8
87-86-5
108-95-2
110-86-1
108-46-3
94-59-7
7488-56-4
93-72-1
79-34-5
127-18-4
137-26-8
108-38-3
71-55-6
79-01-6
75-69-4
95-95-4
38-06-2
100
-------
PEST/DIS-8
2,4,5-Trichlorophenoxyacetic acid U232 93-76-5
(2,4,5-T>*
[acute waste per 261.31]
Warfarin «0.3%) 0248 81-81-2
Xylene U239 1330-20-7
Zinc phosphide «10%) U249 1314-84-7
83 ACTIVES
101
-------
CONT/DIS-1
CONTAINER DISPOSAL INSTRUCTIONS
The label of each product must bear container disposal
instructions appropriate to the type of container.
1. Domestic use products must bear one of the following
container disposal statements:
Container Type
Statement
Non-aerosol products
(bottles , cans, jars)
Non-aerosol products
(bags)
Aerosol products
Do not reuse container (bottle, can, jar).
Rinse thoroughly before discarding in trash.
Do not reuse bag*- Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or puncture.
2. All other products must bear container disposal instructions,
based on container type,Fisted below:
Container Type
Statement
Metal
containers
(non-aerosol)
Plastic containers
Glass containers
Fiber drums
with liners
Paper and
plastic bags
Compressed gas
cylinders
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and disp_ose of in a sanitary landfill, or by
other procedures approved by state and local
authorities.
Triple rinse (or equivalent) . Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or
incineration, or, if allowed by state and
local authorities, by burning, if burned,
stay out of smoke.
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved state and local procedures.
Completely empty liner by shaking and
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reused1, dispose of in the same manner.
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning, if burned, stay
out of smoke .
Return empty cylinder for reuse (or
similar wording)
Manufacturer may replace this phrase with one indicating
whether and how fiber drum may be reused.
102
-------
III. USE INDEX APPENDIX
-------
." EPA Index to Pesticide Chemicala
r
cO~9"9T6t BENOMYL*
TYPE PESTICIDE; Fungicide
FORMULATIONS;
Tech (95*;
FI (SOX)
G (1.1Z, 1.5Z, 1.57Z, 1.6Z, 1.95Z)
WP (25Z, 50Z)
FIG (0.25 lb/g«l or 3Z, 75Z (dry))
• SC/L (0.72 Ib/gal or 10Z)
CENESAL WARNINGS AND LIMITATIONS: Do not allow benomyl to b«coot wet dur-
ing storage. Do not tank mix benomyl with lime or alkaline pesticidea
•uch aa Bordeaux mixture or lime sulfur. Where the uae of apray oil ia
recommended (applea, peanut*, peeana, atone fruita), uae a nonphytotoxic
auperior type (60 to 70 aeeond viaeoaity) apray oil.
If treatment ia not effective due to the pretence of a reaiatant atrain
of fungua, or if when repeated excluaive uae of benomyl baa led to the
buildup of a resiatant atrain, other auitable fungicides should be used.
Conault a State Cooperative Agricultural Extension Service for recommenda-
tions. Do not tank mix or alternate benooyl with formulations containing
active ingredients such aa 2-(4-thia»olyl)benximidarole or diethy1 4,4'-o-
phenylenebia[3-thioallophanate]-«-
Aa a spray, apply with ground equipment (except aa noted) uaing aufficient
water to obtain thorough coverage. Under severe disease conditions, apply
the higher rate and shorter interval apecified for each crop. For tree
crops, apply the higher rate for large, mature treca. For aircraft appli-
cation (on specified crops only), apply the following gallons per acre:
Carrota, rice and aoybeana, 3 to 10; cabbage (seed crop), celery, cucur-
bits, peanuts, and sugar beets, 5 to 10; almonds, avocados, beans, pecans,
stone fruits, and strawberries, 10 to 20; grapes, 15 to 20; roses,
flowers, ornamentals, and shade treea, 20 gallons per acre minimum.
Dosage rates are given in active ingredient unless otherwise apecified.
For use in small gardens and orcharda (less Chan 1 acre), application
rates may be converted to pounda per 100 gallons by dividing the pounds
per acre rate in half, and applying the resulting spray mixture at the
rate of 4.5 gallons per 1,000 square feet. [Note: For the 50 percent
wettable powder, 0.5 pound actual* per 100 gallons equala 0.5 tablespoon
actual* per gallon; and, for the 75 percent dry flowable concentrate, 0.75
pound actual per 100 gallons equala 2.25 tablespoons actual* per 5 gal-
lons.)
Definition o' Terms:
•Tablespoons itbls)' or teaapoona (tap) actual: A hypothetical quantity
computed by multiplying the number (or equivalent number) of tableapoona
(or teaspoons) of product by the concentration of benooyl in the formula-
tion.
a.i. - active ingredient
max. - maximum
Chemical names used in the tank mix statements are the Common Names as
listed in Appendix A immediately following the Listing of Registered Pes-
ticide Products by Formulation.
*benomyllmethyl l-(butylcarbamoyl)-2-beniioidazolecarbamate]
Issued: 8-29-84 II-099101-1 I 0J
-------
EPA Index to Pesticide Chemicals
BENOMY1
GENERAL WARNINGS AND LIMITATIONS (continued)
Agricultural Crop Tolerances;
Broccoli, brussels sprouts, cauliflower, Chinese cabbage, collards, corn,
fresh (including sweet, kernel plus corn with husk removed), corn, sweet
(fodder and forage), eggplants, garlic, kale, kohlrabi, mustard greens,
peppers, rutabagas, spinach, sweet potatoes, turnips (roots), and turnips
(tops) - 0.2 ppa
Currants - 7 ppm
Dandelion - 10 ppm
Papaya - 3 ppm
Livestock and Poultry Tolerances;
Fat, meat, and meat byproducts of cattle, goats, hogs, horses, poultry,
and sheep -0.1 ppm
Poultry liver - 0.2 ppm
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
TERRESTRIAL FOOD CROP —
(Agricultural Crops)
/03001AA Almond 0.2 ppm (negligible residue) nuts
1 ppm almond hulls
Do not apply after full bloom
through 0.75 pound per acre.
FBADMCB Brown rot blossom 0.5-0.75 Ib/A Delayed dormant and foliar applica-
and twig blight (.501 WF) tion. Apply at pink bud. Under
(Monilinia) (75Z F1C) severe disease conditions and on
or highly susceptible varieties, make
0.5-0.75 tsp a second application during half-
actuaWgal to full bloom.
(501 WP)
1 04
Issued: 8-29-84 Il-Of U01-2 lun
-------
EPA Index to Pesticide Chemical*
Sice and Pesc
BENOMYL
Dosages and Tolerance. Use. Limitations
Formalation(s)
/04001AA
Apple (prebarvest/foliar post-
harvest)
FEAJVAG
FMAUSAH
FFACPDJ
FCAFGAL
Apple scab
(Venturis)
Flyspeck
(Schizothyrium)
Powdery mildew
(Podosphaera)
Sooty blotch
(Gloeodes)
1.0-1.5 ox/
100 gal
or
0.16-0.25
tsp actual*/
gal
[tank mixes]
(50Z WP)
(75Z F1C)
. or
2.0-3.0 ox/
100 gal
or
0.375-0.75
esp actual*/
gal
(50Z WP)
7 ppm (pre- and/or postharveat)
70 ppm in dried apple poesce (pre-
and/or postharvesc)
No preharvesc interval through 15.0
ounces per acre. ,
Do not graze livestock in treated
orchard*.
With Golden Delicious, adverse ef-
fects on fruit finish and color may
result; if finish and color are of
primary importance do not use more
than 2.0 ounces active ingredient
per 100 gallons. Apply 200 to 500
gallons per acre with hydraulic
ground equipment, or equivalent
amounts of formulations with con-
centrate sprayers.
Delayed dormant and foliar applica-
tion. • Apply at one-half inch green
tip. Repeat at 7 to 14 day inter-
vals or as needed through cover
sprays. If an application is during
an infection period, apply the high
rates as soon as possible after the
infection period in order to deacti-
vate scab and prevent further infec-
tion. For tank mixes, apply with
9.6 ounces a.i. of mancoxeb per 100
gallons- of water; or with 6.0 to
8.0 ounces a.i. of captan per 100
gallons. One quart of spray oil per
100 gallons water may be added to
the mancoxeb tank mix. Apply the
high rates for varieties more sus-
cmtible to powdery mildew.
Mr be tank mixed with maneb or
capcan at the 0.375 to 0.5 teaspoon
actual* per gallon rate.
Issued: 8•29-84
II-099101-3
105
-------
Sice and Peat
EPA Index to Pesticide Chemical*
BENOMYL
Dosages and Tolerance, Use. Limitation*
Foroulacion(s)
Apple (preharvest/foliar poatharvest) (continued)
FIBFBAW Fruit rot
(Botrytia)
FIBFGAN Fruit rot
• (Gloeoaporium)
FIBFPAQ Fruit rot
(Penicillium)
FCAWAC Overwintering acab
(Venturia)
/04001EA Apple (poatbarveat)
/04003EA Pear (poatharveat)
FIBFBAW Fruit rot
(Botrytia)
FIBFGAN Fruit rot
(Gloeoaporium)
FIBFPAO Fruit rot
(Penicillium)
3.0 os/
100 gal
(501 WP)
(751 F1C)
or
0.5 tap ac-
tual*/gal
(50Z WP)
4.0 oz/
100 gal
(50Z WP)
Foliar application. Apply once,
anytime from 3 veefca before harvest
up to day of harvest.
3.84-4.0 oz/
100 gal
[288-300
ppm a.i.]
(50Z WP)
(75Z F1C)
or
1 volume 3Z
FIG/100 vol-
umes spray
suspension
[300 ppm
a.i.]
(31 F1C)
or
0.75 tsp ac-
tual*/gal
W?)
Foliar application after harvest.
Apply thoroughly to foliage before
leaf drop.
7 ppm (pre- and/or poatharveat)
70 ppm ia dried apple pomace (pre-
and/or poatharveat)
Poatharveat treatment to fruit
through 300 ppm suspension,
Poatharveat treatment to fruit to be
held in storage* Apply the 50 or 75
percent formulationa aa a dip or
apray, and the 3 percent aa a spray.
This treatment ia recommended in
conjunction with the preharvest
apray.
laaued: 8-29-84
II-099101-4
106
-------
EPA Index to Pesticide Chemical*
Sice and Peat
BENOMYL
Dosage* and Tolerancet Use. Limitations
Formulaeion(i)
/05001AA
/OS002AA
/05003AA
/OS004AA
/05005AA
/05006AA
Apricot (preharvest)
Cherry (preharvest/foliar poet-
harvest)
Nectarine (preharvest)
Peach (preharvest)
Plum (preharvest)
Prune (preharvest)
FBADMCS
F1ALMCB
FMBCCDJ
FEAJCCV
FFACQBB
Brown rot blossom
and twig blight
(Monilinia)
Brown rot of fruit
(Monilinia)
Cherry leaf spot
(Coccooyces)
Peach scab
(Cladosporium)
Powdery mildew
0.375-1.0
Ib/A
(50Z WP)
(75X F1C)
or
0.5-1 tsp
actual*/gal
(50Z WP)
15 ppm (pre- and/or postharvest)
No preharvest interval through 1.0
pound per acre.
Do not graxe livestock in treated
orchards. Treatment is most effec-
tive if applied just before rain-
fall. For aircraft application, fly
over every row or center. [Benomyl
does not control peach leaf curl,
shot hole (Coryneum blight), or bac-
terial blast.]
Delayed dormant, foliar application,
and foliar application after harvest
(cherry).
East of the Rocky Mountains;
Apply 0.375 to 0.75 pound per acre
on trees up to 12 feet tall, or 0.75
to 1.0 pound per acre on trees over
12 feet. For brown rot blossom
blight, apply at early bloom stages
(apricota-red bud; peaches, nectar-
ines-pink bud; cherries-early pop-
corn; plums and prunes-green tip).
May be applied with spray oil for
that first application only. Apply
a second time at 75 to 100 percent
bloom. If blossoming is prolonged
or conditions favorable for disease
continue, apply at petal fall. For
brown rot* of fruit (after blossom
blight sprays), apply twice begin-
ning 3 weeks before harvest up to
day of harvest. For peach scab and
powdery mildew, apply the same
schedule as for brown rot blossom
blight, with additional applications
at shuck split, shuck fall, r 14
days later. For cherry leaf spot,
apply the same schedule as for brown
rot blossom blight, and continue at
10 to 14 day intervals through har-
vest. Apply again 2 to 3 weeks af-
ter harvest.
West of the Rocky Mountains;
Apply 0.75 to 1.0 pound per acre.
For brown rot blossom blight, make
first application as above. If
blossoming is prolonged or condi-
tions favorable for disease contin-
Issued: 8-29-84
II-099101-5
107
-------
Sice and Pest
EPA Index to Pesticide Chemical*
BENOM7L
Dosages and Tolerance, Use. Limitation*
Foraulation(j)
Apricot (preharvest) cluster (continued)
0.25-0.5 lb/
100 gal
or
0.5-1 t&la
actual*/
2 g.l
(50Z WP)
0.25 tbls
actual*/gal
(50Z WP)
/05001EA
/05002EA
/05004EA
/05005EA
/05006EA
FICZQBB
Apricot (postharvest)
Cherry (postharvest)
Neccarine (postharvest)
Peach (p'oa tharves t)
Plum (postharvest)
Prune (postharvest)
Postharvest fruit
rots
0.25 lb/
100 gal
[300 ppm
a.i.]
(50Z WP)
(752 F1C)
or
ue, apply a second time 14 days
later. For brown rot of fruit, ap-
ply before rain anytime from 3 veeks
before harvest up to the day of har-
vest. If conditions favorable for
disease continue, or harvest is pro-
longed; apply again. Prebarvest
applications are most effective when
applied with ground equipment. For
powdery mildew and cherry leaf spot,
follow directions for East of the
Rocky Mountains.
Delayed dormant, foliar application,
and foliar application after harvest
(cherry). For brown rot blossom
blight, apply high rate (in combina-
tion with dormant oil) prior to bud
break. Apply low rate at early
bloom (popcorn, red bud, or green
tip) and at full bloom. Apply once
or twice at low rate beginning 3
weeks before harvest. In addition
to the schedule for brown rot blos-
som blight, apply low rate at shuck
split and shuck fall for peach scab,
at shuck fall and first cover for
powdery, mildew, and 2 to 3 weeks
after harvest for cherry leaf spot.
Apply as above. Hay be tank mixed
with maneb or captan for peaches,
or with captan for cherries.
15 ppm (pre- and /or postharvest)
Postharvest treatment to fruits
cnrc-..' 3CO ppa suspension.
{Benomyl does not control fruit rots
caused by Rhizopus spp. and
Alternaria spp.]
Postharvest treatment to fruits.
Apply as soon as possible after
harvest. The 50 and 75 percent
formulations may be applied as a
dip or spray (water or wax spray).
Isau'd: 8-29-34
II-099101-6
108
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EPA Index to Pesticide Chemicals
Site and Pest
BENOMYL
Dosages and Tolerance, Use, Limitations
Formulation(s)
Apricot (postharvest) cluster continued
1 volume 31
PIC/ 100
volumes
spray
[300 ppm
a.i.J
(3* PIC)
or
0.75 tsp ac-
tual* /gal
(50Z WP)
/06001AA
FAAAGAP
FMCBCBM
FEAJSCB
Avocado
/06002AA
Anthracnose
(Glomerella) (50Z WP)
Cercospora leaf and (75Z F1C)
fruit spot or
Scab (spot anthrac- 0.5-0.75 tsp
nose) (Sphaceloma) actual*/gal
[1-1.5 gal/
tree]
(50Z WP)
Banana (preharvest)
3 ppm
14 day preharvest Interval through
1.25 pound per acre.
0.5-1.-25 Ib/A Use limited to FL.
Foliar application. Apply when buds
swell and repeat at 3 to 4 week in-
tervals .
FMBOCBM
Sleatoka disease
(Cercospora leaf
spot)
1.0-2.0 oz/A
(SOS WP)
1 ppm preharvest and postharvest, of
which^not more than 0.2 ppm (negli-
gible re'sidue) shall be present in
the pulp after the peel is removed
and discarded.
No preharvest interval through 2.0
ounces per 'acre.
May be applied by aircraft.
Foliar application. As a spray oil
mixture, apply in I to 2 gi^.ou.- of
nonphytotoxic spray oil per acre.
Or, as an oil-water emulsion, apply
in 0.5 to 1 gallon of nonphytotozic
spray oil per acre with an emulsi-
fier added at the rate of 1 percent
of the oil volume. Apply a minimum
of 2.5 gallons of spray per acre by
aircraft, and at least 5 gallons per
acre with mist blowers. Apply at 2
to 3 week intervals throughout the
complete crop cycle.
Issued: <1-2i--84
II-099101-7
109
-------
EPA Index to Pesticide Chemical*
Site and Pesc
BENOMYL
Dosages and Tolerance. Use, Limitations
Fonnu 1 ation(s)
/06002EA
Banana (preharvest) (continued)
0.5-1 tap
actual*/
1,000 aq.fc
(50Z WP)
Banana (postharvest)
FIAXQBB
FIBFQBB
/28001AA
Crown rot
Surface aolda
Beans
FHACBAW
FHANSAQ
Gray mold
(Botrytia)
White mold
(Sclerotinia)
Foliar application. Apply as an
oil water emulsion using 1.5 fluid
ounces of nonphytotoxie spray oil.
Apply at 2 to 3 week intervals
throughout the complete crop cycle.
1 ppa preharvest and postharvest, of
which not more than 0.2 ppm (negli-
gible residue) shall be present in
the pulp after the peel is removed
and discarded.
Postbarvest dip or spray through 600
ppm a.i. suepension.
0.75-1.5 tap Postharvest treatment to fruits.
actuals/gal Apply as a dip or spray to thorough-
[300-600 ppm ly wet crowns and fruit.
a.i.]
(50Z WP)
2 ppm
50 ppm bean vine forage
14 day preharvest interval for snap
or dry beans, or 28 day preharvest
interval for lima beans through 1.0
pound per acre.
Use on beana grown aa fresh vegeta-
bles, for,processing, or for the dry
bean market. Do not use where crop
is grown only for forage purposes.
0.75-1.0 Ib/A
(50Z WP)
(75Z F1C)
or
0.026 oz/0.5
gai/100
sq.ft
or
0.125-0.25
tbls actu-
al*/0.25-
0.5 gal/100
sq.ft
(SOZ WP)
or
Foliar application. Apply at 25 to
50 percent bloom. Repeat at peak
bloom. For narrow-row (20 to 24
inches) irrigated dry beana in CO,
MT, HE, and WY, apoly at initial
bloom and repeat 7 to 10 days later
(only partial control of white mold
may result).
Isr'.ed. 8-29-84
II -09910'.-8
110
-------
Sict and Pest
EPA Index to Pesticide Chemicals
BENOMY1
Dosages and Tolerance, Use, Limitations
Formulacion(s)
Beans (cesri—
FHANSAQ
/01002AA
/01003AA
/01004AA
/01005AA
/01006AA
FIBFBAW
FIBFPAD
FFACSCO
/01009AA
FAAAGAN
Whiet mold
(Sclerotinia)
Blackberry
Boysenberry
Dewberry
Loganberry
Raspberry
Fruit roc
(Botrytis)
Fruit roc
(Penicilliun)
Powdery mildew
(Sphaerocheea)
Blueberry
Anchracnose
(leaf spot)
(Gloeosporium)
0.04 ox/gal
or
0.25-1 tbls
actual*/gal '
(501 UP)
0.75-1.0 Ib/A Use limited to MN and UI.
(50Z WP) Foliar application. Apply at 25 Co
50 percent bloom. Repeat at peak
bloom. For aerial application, ap-
ply in 4 Co 10 gallons per acre.
7 ppm
3 day preharvesc interval through
0.375 pound per acre.
0.375 Ib/A
(50Z WP)
(75Z F1C)
or
0.25 tbls
actual*/
•gal/ 300
sq.ft
or
0.375 csp
actual*/gal
(50Z WP)
0.5 Ib/A
(50Z WP)
(75Z F1C)
or
0.5 csp ac-
cual*/gal
(50Z WP)
Foliar application. Apply at early
(5 Co 10 percent) bloom and at full
bloom. Make up Co 3 additional ap-
plications ae 14 day interval* as
needed.
7 ppm
21 day preharvesc interval through
0.5 pound per acre.
Do not make more Chan 4 applications
before harvest.
Foliar and poscharvesc application.
'Apply when disease first appears and
make I additional application 14
days later. After harvest, make up
Co 4 applicacions Co the bushes at
14 day intervals as needed.
Issu.-d: 8-29-8-
IT-099101-9
111
-------
Sice and Pest
EPA Index to Pesticide Chemicals
BENOMYL
Dosages and Tolerance. U«e, Limitation*
Fonnulation(s)
FBADBAW
FIBKMCB
/13007BA
FICXSAQ
Blueberry (ccntinued)
Botrytia blossom
blight
Mummy berry (Moni-
linia vaccinii-
coryaboai)
Boyaenberry
Cabbage (seed crop)
Sclerotinia stalk
roc
/28073AA
FHANSAQ
/1300ZAA
FBAMCBM
FSASSBL
Carrots
White rot
(Sclerotinia)
F.Kk-j blight
(Cercospora)
Late blight
(Septoria)
0.5 Ib/A
(50Z Wp)
(73Z F1C)
or
0.5 tsp ac-
tual*/g«l
(50Z WP)
Delayed dormant and foliar applica-
tion. Apply at green tip. Repeat
at 7 to 10 day intervals through
petal fall.
Sea Blackberry cluster.
0.2 ppm
Do not graze treated areas. Do not
use seed or plant parts for food or
feed purposes.
1.0 lb/5-10 Use limited to Pacific Northwest.
gal/A
(50Z WP)
(75Z F1C)
Foliar application. Apply by air-
craft at first petal fall. Make 2
additional applications at 14 day
intervals if conditions favor dis-
ease development. Add a suitable
spreader-sticker.
0.2 ppm
4 day preharvest interval through
0.5 pound per acre.
0.125-0.5
Ib/A
(50Z WP)
Foliar Application.
ease first appears.
10 day intervals.
Apply when dis-
Repeat at 7 to
3 ppm
7 day preharvest interval through
0.25 pound per acre.
0.125-0.25
Ib/A
(so: wp)
(75Z F1C)
or
0.5 tsp ac-
tual*/ 0.5
gal/150
sq.ft plant
bed
(50Z Wp)
Foliar application.
ease first appears.
10 day intervals.
Apply when dis-
Repeat at 7 to
or
Issuec: 8-29-84
I! -099101-10
112
-------
Sice and Pest
Celery (concinued)
EPA Index to Pesticide Cheaicala
BENOMYL
Dosages and Tolerance. Use. Limitations
Forsulacion(s)
0.125-0.25
tap actu-
al*/gai
(50Z WP)
/02000AA
Cherry (preharvest/foliar post-
harvest)
Cherry (postharvest)
Citrua Fruits
FZBFPAO
FIBFPAD
FICIQBB
FMAYMCO
See Apricot (preharvest) cluacer.
See Apricot (poatharvesc) cluacer.
10 ppa (prt- and/or poatharveat)
50 ppa in dried citrua pulp (pre-
and/or poatharveat)
No preharveat through 1.0 pound per
acre; or, do not apply later than
•id-July through 1.5 pounda per
— acre.
Do not graze liveatock in treated
grovea.
Blue mold (Penicil- 0.5-1.0 Ib/A Foliar application. Apply once any
liua italic.ua) (501 WP) time froa 3- veeka prior to harvest
Green mold (Peni- (75Z F1C)
cilliua digitatua) or
Stem-end rot 0.5-1 tap
aetual*/gal
(50Z WP)
up to day of harvest.
Greasy spot
(Mycoaphaerella)
FAABEAH
0.75*1.5 Ib/A Foliar'application. Apply once dur-
(50Z WP) ing the period aid-June to aid-July.
(75Z F1C)
or
0.75-1 tap
actuaWgal
(50Z WP)
Scab (spot anthrac- 0.75-1.5 Ib/A Foliar application. Under condi-
noae) (Elainoe)
(50Z WP)
(7SZ F1C)
or
0.25 cbla
actual*/
2 gal
[max. 10
gal/tree]
(50Z WP)
or
tiona of severe disease pressure,
apply at pinhead stage (just prior
to first flush). Repeat at two-
thirds petal fall. Otherwise, make
a single application at two-thirds
petal fall.
Issued: 8-29-84
ir-099101-il
113
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Sice and Pesc
EPA Index to Pesticide Chemical*
BENOMYL
Dosages and Tolerance. Use. Limitations
Forsulacion(s)
Citrus Fruits (continued)
0.75-1
actual*/gal
(50Z VP)
/02000EA
Citrui Fruits (postharvest)
FIBFPAO
FIBFPAO
FICIQBB
Blue mold (Penicil- 0.5-1.0 lb/
lium italicum) 100 gal
Green mold (Peni- [600-1,200
cillium digitatum) ppm a.i.]
Stem-end rot (50Z WP)
(75Z F1C)
or
1-2 volumes
31 F1C/50
volumes
[600-1,200
ppm a.i.]
(3Z F1C)
or
1-2 tsp ac-
tual*/ gal
(50Z WP)
10 ppm (pre- and/or postharvest)
50 ppm in dried citrus pulp (pre-
and/or postharvest)
Postharvest treatment to fruits
through 3,000 ppm wax spray suspen-
sion.
The 0.72 pound per gallon or 10 per-
cent formulation is to be used in
the manufacturer's wax, prepared by
a manufacturer's representative, and
applied in the manufacturer's wax
apray applicator.
Postharvest treatment to citrus
fruits. Apply as a dip, flood, or
spray. May be applied in water or
in a citrus wax spray. Do not im-
merse fruit more than 5 minutes in
suspensions with 50 or 75 percent
formulations. Use the higher rate
on more susceptible fruits and when
excessive inoculum levels are pre-
sent. If fruit is stored wet after
treatment, adjust storage conditions
to obtain* fruit drying within 48
hours.
I volume 1CZ. Postharvest treatment to citrus
SC/L/100 fruits. Apply 1 gallon of wax with
volumes wax benomyl to each 5,000 pounds of
[1,000 ppm fruit.
a.i.]
(0.72 Ib/gal
or 10Z SC/L)
Issu-sd: 8-29-8 <\
11-099101-12
114
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EPA Index Co Pesticide Chemical•
Sice and Pest
BENOMYL
Dosages and Tolerance. Use, Limitations
Fonoulacioa(s)
Citrus Fruits (poacbarvesc) (continued)
/10010AA Cucumber
/10001AA Melons
AOOllAA Pumpkin
/10013AA Sunmer Squash
/10014AA Winter Squash
FAAACDP Anehracnose
(Collecocrichum)
FBAQMCO Gunny seem blight
(Mycosphaerella)
FFACEBJ Powdery mildew
(Erysiphe)
FMBCCEK Target leaf spot
(Corynespora)
(on cucumbers)
2.0 lb/100
gal citrus
wax
12,400 ppm
a.i.]
(501 WF)
(75Z riC)
or
2 volumes 3Z *
PIC/25 vol-
umes wax
.emulsion
[2,400 ppm
a.i.]
(31 F1C)
or
1 volume 10Z
SC/L/33 vol-
umes wax
[3,000 ppm
a.i.]
(0.72 Ib/gal
or 10Z SC/L)
or
4 tsp actu-
al+/gal w«x
(50Z WP)
Postbarvest treatment to citrus
fruits. Apply as a spray to control
Penicillium spp. sporulation.
0.125-0.25
Ib/A
(50Z WP)
(75Z F1C)
or
0.0053 ox/
100 sq.ft
or
0.25 or/12.5
gal
(50Z WP)
or
1 ppm ' .
No preharvest interval through 0.25
pound per acre.
Foliar application. May be applied
by aircraft •'•« the high rate. Apply
when pleats begin to run or when
disease first appears. Repeat at 7
Co 14 day intervals as needed. For
target spot, apply at 7 day inter-
vals as needed.
Issued: 8-29-84
11-099101-13
115
-------
Site and Pest
EPA Index to Pesticide Chemicals
BENOMYL
Qosagea and Tolerance. Use. Limitations
.Formulacion(s)
Cucumber cluster (continued)
/01014AA
FIADMAV
FIBFGBC
FFACUAB
Bitter rot
(Melanconium)
Black rot
(Guignardia)
Powdery mildew
(Uncinula)
0.1-0.17 tsp
actual*/0.5
gal/100
•q.ft
or
0.028-0.056
tap actual*/
100 aq.ft
or
0.125-0.25
tsp actual*/
gal
or
0.125-0.25
tbal actu-
al*/gal
(50Z
See Blackberry clutter.
10 ppa
50 ppm rail in*
125 ppm in dried grape pomace and
raiain waate
7 day preharveat interval through
0.75 pound per acre.
[Benomyl does not control bunch rots
caused bjt Rhizopua spp., Alternaria
•pp., or Diplodia spp.]
0.375-0.75 Use limited to East of the Rocky
lb/A Mountains.
(50Z WP) Delayed dormant and foliar applica-
(75Z F1C) tion. Apply when foliage first de-
or velops. Repeat at 14 to 2-- day in-
0.75-1.5 tbls tervals, or as needed, uuc.x berries
actual*/ 2 are full size.
gal
or
0.375-0.75
tsp actual*/
(50Z WP)
Issued: 8-29-84
IT.-099101-14
116
-------
Site and Pese
Crapes (continued)
EPA Index to Pesticide Cheaieala
BENOMYL
Dosagea and Tolerance, Use, Linicationa
Formulation(s)
FIARBAW
Botrytis bunch roe 0.5-0.75 Ib/A Foliar application. Apply at first
bloom (no later than 5 percent
bloom) and repeat 14 days later if
aevere disease conditions persist*
Make an additional application 3 to
4 veeka before harvest or when sugar
begin*, to build. Repeat 14 days
later if conditions favorable for
disease persist.
(50Z WP)
(751 WP)
or
1-1.25 tbls
actual*/2
or
0.5-0.75 t*p
actual*/gal
(50Z WP)
/03007AA
FBADBAW
Loganberry
Macadamia Nut
Botrytis blossom
blight
0.875 Ib/A
(50Z WP)
(75Z F1C)
or
0.875 cap
actual*/gal
(50Z WP)
/06007AA
FAAAGAP
Anthracnose
(flower and twig
0.5-1.0 Ib/A
(50Z WP)
blight/fruit spot) (75Z F1C)
(Glomerella) or
0.5-1 tap
actual*/gai
,;:* v?)
See Blackberry cluster.
0.2 ppm (neglibie residue) nuta
Do not apply after bloom period
through 0.875 pound per acre.
Use limited to HI.
Foliar application. Apply 1 to 2
weeks prior to bloom* Repeat at 7
to 14 day intervals through the
bloom period. A suitable surfactant
may be added.
3 ppm
14 day ^preharves t interval through
1.0 pound* per acre.
Foliar application. Apply at first
appearance of panicles (approximate-
ly 2 inches long). Repeat at weekly
intervals until all fruits are set.
Continue at 3 to 4 week intervals.
Melons
See Cucumber cluster.
Tssued: 8-29-84
11-099101-15
117
-------
/16003AA
FGAFVAK
Site and Pest
Mushrooms
EPA Index to Pesticide Chemical•
BENOMYL
Dosages and Tolerance. Ose. Limitations
Fonnulacion(s)
10 ppm
2 day preharvest interval through
1.0 ounce per 1,000 square feet.
Verticillium spot
(dry bubble)
0.5
100 gal
or
1.0 or/
1,000 sq.ft
(50Z WP)
(75Z F1C)
or
1.5 tsp actu-
al/gal
(50Z WP)
Soil application. Apply 12.5 gal-
lons suspension per 1,000 square
feet. Apply to bed surface ionedi-
ately after casing and repeat at
pinning. Or, if disease has oc-
curred, apply to beds after picking
and repeat 10 days later.
/2801S4AA
Nectarine (preharvest)
Nectarine (postharvest)
Peach (preharvest)
Peach (postharvest)
«
Peanuts
FMBCCBM
Leaf spot
(Cercospora)
0.125 Ib/A
(50Z WP)
(75Z FiC)
0.188-0.25
Ib/A
or
0.5 oz/12.5
1*1
(50Z WP)
See Apricot (preharvest) cluster.
See Apricot (postharvest) cluster.
See Apricot (preharvest) cluster.
See Apricot (postharvest) cluster.
0.2 ppm
2 ppm hulls
15 ppm forage or hay •
14 day preharvest interval through
0.25 pound per acre.
Do not graze or feed vines, hay, or
bulls treated with tank mix to live-
stock.
Foliar application. Tank mix with
1.2 pounds a.i. mancozeb per acre.
(Ascochyta web blotch and rust will
also be controlled.) Spray oil may
be added (0.5 to 1 quart per acre).
Apply 35 to 40 days after planting
or when disease first appears. Re-
peat at 10 to 14 day intervals.
Foliar application. Apply 35 to 40
days after planting or when disease
appears. Repeat'at 14 to 21 day
intervals.
Issued: 8-29-84
11-099101-16
118
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EPA Index Co Pesticide Chemical*
Sice and Pest
/04003AA
FMAUSAH
FEAJVAC
FFACPDJ
FCAFGAL
FIBFBAW
FIBFGAN
FIBFPAO
FGAWAC
BEMOMYL
Dosages and Tolerance, Ute. Limitaciona
Fonnulacion(s)
Pear (preharvest/foliar poat-
harvese)
Flyapeck
(Schizothyrium)
Pear acab
(Vencuria)
Powdery mildew
(Podoaphaera)
Soocy blotch
(Gloeodes)
Fruit rot
(Botrytis)
Fruit rot
(Gloeoaporium)
Fruit rot
(Penieillium)
Overwintering acab
(Venturia)
2.0-3.0 ox/
100 gal
[200-500
gal/A)
(50Z WP)
(75Z F1C)
or
0.375-0.5 tap
actuallygal
[1-2 gal/
average
sized tree]
(501 WP)
3.0 oz/
100 gal
(501 WP)
(75Z F1C)
or
0.5 tap ac-
tual*/gal
(50Z WP)
4.0 oz/
100 gal
(50Z WP)
(75Z F1C)
or
0.75 tap ac-
tual*/gal
(50Z WP)
7 ppm (pre- aad/or poatharveat)
No preharvest interval through 15.0
ounces per acre.
Do not graze livestock in treated
orcharda.
Apply 200 to 500 gallons per acre
with hydraulic ground equipment, or
equivalent amounts of benomyl with
concentrate aprayera.
Delayed dormant and foliar applica-
tion. Apply at one-half inch green
tip and repeat at 7 to 14 day inter-
vala or aa needed through cover
apraya. If an application ia missed
during an infection period, apply
the high rate aa aoon aa possible
after the infection period in order
to deactivate acab and to prevent
further infection.
Foliar application. Apply once,
anytime from 3 weeks before harvest
up to day of harvest.
Foliar application after harvest.
Apply thoroughly to foliage before
leaf drop.
Pear (postharveat)
See Apple (poatharvest) cluater.
I.«sued: 8-29-84
11-099101-17
119
-------
EPA Index co Pesticide Chemical*
• Site and Peat
/03008AA
FKBCCBM
FMASMCO
FGAKQBB
FMBDGAT
FEAJCCV
FFACMBT
Pecan
Brown leaf spot
(Cercospora)
Downy leaf spot
(Mycoaphaerella)
Fungal leaf acorch
Liver spot
(Gnomonia)
Pecan scab
(Cladosporium)
Powdery mildew
(Microaphaera)
BENOMYL
Dosages and Tolerance, Use. Limitation*
Fonnulation(s)
0.2 ppm (neglible residue) nuts
Do not apply after shuck split
through 0.5 pound per acre.
0.25-0.5 lb/A
(50Z WP)
(75Z F1C)
or
0.5 tsp ac-
tual*/gal
[1-2 tsp
oil/gal]
or
0.625 tap
actual*/gal
[max. 20
gal/tree]
(50Z WP)
/06013AA
FICVTAK
Pineapple (seed piece)
Butt rot
(Thielaviopsis)
0.625 lb/
100 gal
water
(50Z WP)
(75Z F1C)
or
2 tsp actu-
al*/ gal
(50Z WP)
FI'FTAK
Thielaviopsis rot
1.0-2.0 lb/
100 gal
water
(SOZ WP)
(75Z F1C)
or
3-6 tsp ac-
tual/gal
(50Z WP)
Plum (preharvest)
Plum (postharvest)
Delayed dormant and foliar applica-
tion. Apply the higher per acre
rate on trees over 30 feet tall.
For aircraft application la AR, LA,
MS, OK, and IX, apply at high rate.
Spray oil may be added (1 to 2 gal-
lons per acre). Apply at prepolli-
nation when young leaves are unfold-
ing, when small nuts are fontiag,
and then at 3 to 4 week intervals.
Do not apply more than 20 gallons of
spray per tree using the tablespoon
rate.
N.F.
k
Seed piece treatment. Apply as a
preplant dip immersing seed pieces
to give thorough wetting. Remove
and allow to drain.
pounds per 100 gallons. Do not im
merse more than 5 minutes.
Postharvest treatment to fresh
fruit. Immerse or spray fruit im-
mediately after harvest. Allow ta
drain.
See Apricot (preharvest) cluster.
See Apricot (postharvest) cluster.
Issued: 8-29-84
11-099101-18
120
-------
/28072AA
FHAHPCR
FICHQBB
/28023AA
FAAAGAP
FBAYDAP
FMAVCBM
FKACCBM
FMAJSBL
Sice and Pese
Prune (preharvest)
Prune (postharvest)
Pumpkin
Raspberry
Rice
EPA Index Co Pesticide Qieaicals
BENOMYL
Dosages and Tolerance, Use, Limitations
FormulationCs)
See Aprieoe (preharvest) cluster.
See Apricot (postharvcat) cluster.
See Cucumber cluster.
See Blackberry cluster.
5 pp» ./
15 pp» riet straw
20 ppm rice hulls
21 day preharvest interval through
l.Oipound per acre.
Do not apply Co stubble rice. Do
not epply to fields where crayfish
or catfish farming is practiced, nor
drain water from treated areas into
areas where such farming is prac-
ticed. Water drained from treated
areas must not be used to irrigate
other crops.
Blast (rotten neck) 0.5-1.0 Ib/A
(Piricularia) (501 WP)
Stem rot ' (75Z F1C)
Soybeans
Ar.chracr.cse
(Glomerella)
Diaporthe pod and
stem blight
'-ogeye leaf spot
vCercospora)
Purple seed stain
(Cercospora)
Septoria brown rot
Use limited to areas other than CA.
Foliar application. Apply at boot-
ing and repeat at heading.
0.2 ppm
35 day preharvest interval through
0.5 pound per acre.
Do not ^graze or feed treated soybean
vines or hay to livestock.
0.25-0.5 ID/A Foliar application. Tc.. ce:.£.—_::£.; =
(50Z WP) varieties (generally grown in the
(75Z F1C) South), epply at early pod set when
majority of pods are one-eighth to
one-half inch long. For indetermi-
nate varieties (generally grown in
the North), apply when pods near the
top of the plant are one-half to 1
inch in length. Make 1 additional
application 14 to 21 days later.
Itsued: 8-29-f'v
11-099101-19
121
-------
EPA Index Co Pesticide Chemicals
/28023BA
Sice and Pesc
Soybean* (seed crop)
FBAYDAP
Diaporthe pod and
•tern blight
/01016AA
FAAACOP
Strawberry
Anthracnoae
(Collecocrichum)
FHACBAW
FGAKDBS
FMBCMCO
FFACSCO
Gray aold
(Botryti*)
Leaf scorch
(Diplocarpoa)
Leaf spoc
(Mycosphaerell.**)
Powdery mildew
(Sphaerotheca)
BENOMYL
Dosages and Tolerance. Use. Limitations
Foraulacion(s)
0.2 ppm
Single application through 1.0 pound
per acre. Do not apply within 35
day* of harvest.
Do not graze or feed treated soybean
vines or hay to livestock.
0.5-1.0 Ib/A
(50Z WP)
Use limited to Midwest States.
Foliar application. Make a single
application when beans are develop-
ing in pods at 1 of the 4 uppermost
nodes with a completely unrolled
leaf.
5 ppm
Mo preharvest interval through 0.5
pound per acre. •
Delayed dormant and foliar applica-
tion. Apply when plants are estab-
lished in plant bed or field. Re-
peat at 7 day intervals.
0.5 Ib/A
(50Z WP)-
(75Z F1C)
or
1.0 os/12.5
gal
or
0.5 tap ac-
tual*/ gal
(50Z WP)
0.25-0.5 Ib/A Foliar application. Apply the high
(501 WP) rate at 10 .percent bloom and at full
1 •• ~'~ »~* =* " " ' -•• —
0.5-1.0 ox/
12.5 gal
or
0.25-0.5 tap
actual*/
gal/200
sq.ft
or
0.25-0.5 tbls
actual*/gal
(50Z WP)
ar.i.s us^r.g low rate
Issued: 8-29-84
122
II-099101-"0
-------
EPA Index to Pesticide Chemicals
Sice «nd Pest
BENOMSTL
Dosages and Tolerance, Use, Limitations
Fornulacion(s)
/01016DA
F1AXBAW
FMBCMCO
Strawberry (transplants)
Botrycis crown roc
Leaf spoc
(Mycosphaerella)
/28020AA
Sugar Beets
FH5CCBM
/25003AA
FIBSCBI
Leaf spot
(Carcospora)
Sugarcane
Pineapple disease
(Ceraeocyscis)
0.25 lb/
100 gal
water
(50Z WP)
(751 F1C)
or
0.75 tap ac-
tual*/ gal
(501 WP)
0.188-0.25
Ib/A
(50Z WPJ.
(75Z FIG)
0.25 lb/100
gal water
[300 ppm
a.i.]
or
0.125 lb/100
££. Wili'.
1153 pps
a.i.]
(50Z WP)
(75Z F1C)
5 ppm
Dip treatment to transplants. Im-
merse plants Co give cborough wet-
ting. Remove and allow to drain.
Summer Squash
0.2 ppm sugar beec roocs
15 ppm sugar beet cop*
21 day preharvese interval through
0.25 pound per acre.
Foliar application. Apply when dis-
ease first appears. Repeat ac 14
Co 21 day intervals as needed.
H.F.
Do noc us* created seed cane for
food or feed purposes.
Use limited to BI.
Seed cane treatment. Apply to cut
seed cane as cold dip or hoc dip.
As a cold dip (300 ppm active ingre-
dient) ," immerse seed cane Co give
chorough weccing. Remove and allow
to drain. As a hot dip (150 com
trcive ir.grecien;;, soal-c. seed cane
for 20 to 30 minuces ac 122 F
(50.0 C). Remove and allow Co
drain.
See Cucumber cluster.
Issued: 8-29-84
H-099101-21
125
-------
EPA Index Co Pesticide Chemical*
/11005AA
FHACBAW
FHACCCV
•
FMBCCBM
FMAEPBS
FICHSAQ
Sice and Peat
Tomato
Gray aold
(Botrytis)
Leaf mold
(Cladosporiua)
Leaf spoc
(Cercospora)
Phoma black spot
of leaf
Timber roc
(Sclerocinia)
Winter Squash
BENOffifL
Dosages and Tolerance. Use, Limitations
Foraulation(s)
5 ppo
50 ppm eonce'neraced tomato produces
No preharvest interval through 0.5
pound per acre.
0.25-0.5 Ib/A Foliar application. Apply when dis-
(50Z UP) eaae first appears. Repeat at 7 to
(75Z F1C) 14 day intervals as needed.
or
0.5 ox/12.5
gal
or
0.5-1 tbls
actual*/2
gal
or
0.25-0.5 tap
actual*/gal
(50Z WP)-
See Cucumber cluster.
/34022AA
/34022CA
/34058AA
/34058CA
/35056AA
/31126AA
/31126CA
/34088AA
/ 34088 CA
/31000AA
/31000CA
/35000AA
/35000CA
/34004AA
/34004CA
/34118AA
/34118CA
TERRESTRIAL NON-FOOD CROP
(Ornamental Plants and Forest Trees)
Azalea
Firethorn
Flov<;r:-r C-^*---g!e
Iris
Li gu strum
Ornamental Herbaceous Planes
Ornamental and/or Shade Trees
Ornamental Woody Shrubs
Rhododendron Hybrids /Cultivars
Addition of a surfactant to the
spray mixture improves distribution
of the spray on hard-to-wet plants.
124
Issued: 8-29-84
11-099101-22
-------
Sice and Pest
EPA Index co Pesticide Qiemicals
BENOMYL
Dosagea and Tolerance, Uief Limicacioni
Formulaeion(s)
FAAAQBB
FBAAACC
FMBCCBM
FMBCCEK
FMBCDBD
FMBCEAW
FMBCRAD
FMBCSBL
FBADOAV
FBAAPBU
FEAJFAH
FEAJVAG
FHACBAW
FFACQBB
Azalea eluacer (continued)
Anthracnose
Ascochyta blight
Leaf spot
(Cercospora)
Leaf apoc
(Corynespora)
Leaf «pot
(Didymellina)
(of iri.)
Leaf «poe
(Encomosporium)
Leaf «poc
(Ranularia)
Leaf spot
(Sepcoria)
Ovulioia petal
blight (of azalea
and rhododendron)
Phomopais blight
Scab (Fusieladiuo)
(of firethorn)
Scab (Vencuria)
(of flowering
crabapple)
Botrytia gray mold
Powdery mildew
0.5 lb/ 100
gal
or
0.25-0.5 Ib/A
(aircraft)
(50Z WP)
(75Z F1C)
or
0.5 tbls ac-
tual*/gal
(SOZ WP)
or
0.75 tbla
actual*/
5 gal
(75Z F1C)
Foliar application. Apply when dia-
eaae first appears and repeat at 10
to 14 day intervals throughout grow-
ing season. Shorten interval during
huaid, rainy weather, tot Qvulinia
petal blight, apply beginning aa
flowera open. For anthracnose on
shade trees and woody ornamentals,
apply at bud break and make 2 or 3
additional applications at 10 to 14
day intervals.
0.25 lb/100 Foliar application. Apply when dis-
gal eaae first appears and repeat at 10
or to 14 day intervals throughout grow-
0.25-0.5 Ib/A ing season. Shorten interval during
(50Z UP) humid, rainy weather.
v7!~ iiC)
or
0.04 oz/gal
(50Z WP)
or
0.25 tbls ac-
tual*/ral
(251, 50Z WP)
or
0.75 tbls
actual*/5
gal
(75Z F1C)
125
Issued: 8-29-84
11-099101-23
-------
EPA Index eo Pesticide Chemicals
FICHBAW
FICYBAW
FICKFAK
FICYFAK
FICHRAM
FICYRAM
FICHSAQ
FICYSAQ
FIAACFO
FIAATAK
/31083AA
/31093AA
/31111AA
/31126AA
/31025AA
FIAPFAK
FIAPPAO
Site and Peat
Azalea clutter (continued)
BENOMYL
Dosages and Tolerance. Use, Linitationa
Fonnulatioo(«)
Botrytia stem,
crown and root
rota
Fusarium atem,
crown and root
rota
Rhizoctonia atem,
crown and root
rota
Sclerotinia item,
crown and root
rota
Cylindrocladiuo rot
Thielaviopsis rot
0.5 lb/
100 gal
or
1.0-2.0 oz/
100 aq.ft
(50Z UP)
(75Z F1C)
or
0.5 tbla ac-
tual* /gal
(501 WP)
Daffodil
Eaacer Lily
Gladiolus
Basal rot (Fusarium)
Penicillium rot
0.5 lb/
100 gal_
(50Z WP)
(75Z F1C)
or
0.5 tbls ac-
tual*/gal
(50Z WP)
0.83 lb/
100 gal
(50Z WP)
(75Z F1C)
or
0.17 oc/gal
or
0.83-1 tbla
actual*/gal
(50Z WP)
or
2.625 tbla
actual*/4
gal
(75Z FIG)
Foliar and aoil application. Apply
aa^a drench or heavy spray (1 to 2
pints of auapenaion per square foot)
after transplanting into propagation
beda or containers. Repeat at 2 to
4 week intervals during periods fa-
vorable for diaeaae. Apply for
stem, crown, and root rota on herba-
ceous annuals, perennials, and bed-
ding plants; and for Cylindrocladiun
and Thielaviopsis rots on woody or-
naaentala such aa azalea, rhododen-
drons, conifers, and poinaettiaa.
[Benoayl doea not control Pythium
app. or Phytophthora spp.J
Preplant dip treatment. Immerse
plants or cutting's for 10 to 15
minutes. Remove and allow to
drain. Apply for diaeases on the
planta listed above.
Sulh sr.= csrrs trtatsest. Scs>.
cleaned bulba or conns for 15 to 30
minutes in warm dip (80 to 85 F
(26.7 to 29.4 c» preferably within
48 hours after digging. Dry bulba
after treatment for atorage. If
bulba are for forcing, treat after
bulbs have been heat-cured.
laaued: 8-29-84
11-099101-24
126
-------
EPA Index Co Pesticide Chemical*
/35049AA
Site and Pest
Elm
FGAGCBI
Dutch Elm Disease
(Ceratocystis
ulmi)
BENOMYL
Dosages and Tolerance. Use, Limitations
Formulation(s)
Use foliar spray or trunk injection
treatment as in aid in the control
of Dutch Elm Disease. For use by
trained aborists in conjunction with
sanitation and insect control pro-
grams. Best results are obtained
if treatment is aade on trees vith
no more than 5 percent crown damage.
4.0 lb/
100 gal
[concentrate
•prayer or
mist blower]
or
1.0 lb/100
[hydraulic
sprayer]
(50Z WP)
1.0 lb/
100 gal
or
1.5 oz/3 gal
(501 WP)
Foliar application. Apply 2 to 4
gallons of spray per mature tree
with a concentrate sprayer or mist
blower, or 10 to 20 gallons with
hydraulic spray equipment. A suit-
able surfactant may be added. Apply
in the spring when trees reach full
leaf (the period when elm bark bee-
tles usually begin feeding).
Trunk injection. Treatment may be
made anytime during the growing sea-
son,, preferably in the spring when
trees reach full leaf. Repeat
treatments may be made and are de-
sirable if new infections occur.
Gravity method. Use injector tubes
equipped with cups of approximately
2 fluid 'ounces capacity. Insert in-
jector tubes into outer growth rings
just far er?urh so liquid ^ill sot
le&k ac pol_i c,f fcL.iiy. Space at 2
inch Intervals around the trunk.
Fill cups and leave in place for 24
to 48 hours. Refill cups as needed.
Remove injector tubes when treatment
has been completed.
Pressure method. Inject the suspen-
sion into the trunk of the tree with
a pressure injection device at 20
to 30 pounds pressure per square
inch. Inject approximately 1 gallon
of suspension per each 10 inches of
trunk diameter, the amount generally
injectable in 0.5 hour for trees 10
inches or more in diameter. Use at
least 1 injection site for each 10
inches of trunk circumference. For
Irs jet': 8-29-84
11-099101-25
127
-------
EPA Index to Pesticide Chemicals
Site and Pest
Elm (continued)
/311A7AA
/31147CA
Orchids
BENOMYL
Dosages and Tolerance. Use, Limitations
Formulation(s)
smaller trees, use the amount of
material injectable in 0.5 hour.
Do not use inside living areas of
dwellings. Spray out of doors. A
suitable surfactant is recommended.
Refer to manufacturer's literature
for detailed descriptions and direc-
tions.
On colored flowers, benomyl may
leave a slight, noticeable residue.
FAAACDP
FAAAGAP
FMBCCBM
FMBCPCE
FBADBAW
FGATFAK
FICBRAM
American
anthracnose
(Colletotrichum)
European
anthracnose
(Gloeoaporium)
Leaf spot
(Cercospora)
Leaf spot
(Phyllosticta)
Petal blighf
(Botrytis)
Fusarium wilt
Rhizoctonia root
rot
0.5 tbls
actual*/gal
(50% WP)
0.5 tbls
actual*/gal
(50Z WP)
Foliar application. For anthrac-
nose, apply when disease first ap-
pears and repeat in 7 days if need-
ed. Cut off and destroy infected
plant parts. For leaf spots, apply
3 times at 2 week intervals. There-
after, spray once a month, if need-
ed. For petal blight, apply monthly
as a preventive. Where petal blight
is severe, spray flowers just prior
to opening and 7 days later.
Dip or drench treatment. Dip for 5
minutes. Repeat in 2 weeks if
needed. •
Issued: 8-29-8'
II-399?.01-26
128
-------
Site and Pest
EPA Index to Pesticide Chemicals
BENOMYL
Dosages and Tolerance, Use, Limitations
Formulation(s)
/33008AA
Ornamental Turf (athletic fields,
commercial turf areas, golf
courses, lawns, parks)
FBAHRAM
FMAQSAQ
Brown patch
(Rhizoctonia)
Dollar spot
(Sclerollnia)
FBAAFAK
0.5-1.0 oz/
1,000 sq.ft
(1.5%, 1.57Z,
1.6Z G)
(50Z WP)
or
3-6 this
actual*/
1,000 sq.ft
(25Z, 50Z WP)
0.5-1.0 oz/
1,000 sq.ft
(1.1Z 6)
(1.95Z G)
Fusarium blight
(Fusarium roseum
and F. tricinctum)
2.5-4.1 oz/
1,000 sq.ft
(1.6Z G)
(50Z WP)
or
15-24 tbls
actual*/
1,000 sq.ft
(50Z WP)
Do not graze or feed clippings from
treated areas to livestock. When
treating golf greens, always treat
aprons and approaches. Apply wet-
table powder in sufficient water for
thorough coverage, usually. 2 to 5
gallons per 1,000 square feet. Un-
less specified otherwise for granu-
lar formulations, water after appli-
cation. The 1.95 percent granular
formulation includes fertilizer.
Foliar application. Apply low rate
for dollar spot, and high rate for
brown patch. Wettable powder may be
tank mixed at low rate with maneb
(2.4 to 3.0 ounce a.i.) or chloro-
thalonil (1.5 to 3.0 ounce a.i.).
Apply when disease first appears and
continue at 10 to 14 day intervals
as long as needed. When conditions
are unusually favorable for the
development of brown patch, reduce
interval to 5 to 7 days.
Foliar application. Apply to either
moist or dry foliage. As a preven-
tive, apply low rate in late spring.
Repea( at 2 or 3 week intervals.
Shorten 'interval during conditions
favorable to brown patch. As a cur-
ative, apply zhe 1.S5 percent forxu-
lation at the high rate for dollar
spot and at the low rate for brown
patch. Apply the 1.1 percent formu-
lation at the high rate as a cura-
tive for either disease.
Foliar application. Apply when dis-
ease first appears. Repeat 10 to 14
days later. Immediately after ap-
plication, water sufficiently to
thoroughly wet soil to a depth of
1 inch below any sac or thatch
present.
Issued: 8-29-54
11-099101-27
129
-------
Site and Pest
EPA Index to Pesticide Chemicals
BENOMYL
Dosages and Tolerance. Use, Limitations
Foraulation(s)
Ornamental Turf (continued)
FHAJFAK
Fusariua patch
(snow mold)
(Fusariua nivale)
FLAIJUAL
Stripe smut
(Ustilago)
/34120AA
/3A120CA
FMA£DBS
FFACSCO
Rose
Black spot
(Diplocarpon)
Powdery mildew
(Sphaerotheca)
1.0 oz/
1,000 sq.ft
U.6Z G)
(251, 50Z VP) needed.
or
6 tbls
actual*/
1,000 sq.ft
(501 WP)
Foliar application. Apply when dis-
ease first appears and continue at
10 to 14 day intervals as long as
1.0 oz
1,000 sq.ft
(1.1Z G)
(1.95Z G)
3.0-3.13 oz/
1,000 sq.ft
(1.5Z.-1.57Z,
1.6Z G)
(50Z VP)
or
18 tbls ac-
tual*/!, 000
•q.ft
(50Z WP)
Foliar application. Apply to either
moist or dry foliage. Apply when
disease first appears. Repeat if
needed.
Foliar application. Apply once in
October or early spring before grass
begins growth. Water turf suffi-
ciently to carry formulation to
base of plants.
0.5 lb/100
gal
or
0.25-0.5
Ib/A
(so: WP)
(75Z F1C)
or
0.04 oz/gal
(50Z WP)
or
0.25-1 tbls
actual*/gal
(252, 50Z WP)
or
Addition of a surfactant to the
spray mixture improves distribution
of the spray.
Foliar application. Apply when dis-
ease first appears and repeat at 10
to 14 day intervals throughout the
growing season. Shorten intervals
during humid, rainy weather.
Issued: 8-:1-84
H-099101-28
130
-------
Site and Pest
Rose (continued)
EPA Index to Pesticide Chemicals
BENOMYL
Dosages and Tolerance. Use, Limitations
Fonnulation(s)
1.5 this ac-
tual*/ 5 gal
(75Z F1C)
See Azalea cluster, Botrytis gray mold, for addi-
tional Information.
/11005CA
FHACBAW
FHAGCCV
FMBCCBM
FMAEPBS
FICHSAQ
GREENHOUSE FOOD CROP
(Agricultural Crops)
Tomato (greenhouse)
Gray mold
(Botrytis)
Leaf mold
(Cladosporium)
Leaf spot
(Cercospora)
Phoma black spot
of leaf
Timber rot
(Sclerotinia)
0.25-0.5 lb/
100 gal
(SOX WP)
(75Z F1C)
or
0.5-1.5 tsp
actual*/gal
(50* WP)
5 ppm
50 ppm concentrated tomato products
No preharvest interval through 0.5
pound per 100 gallons.
Foliar application to greenhouse
grown plants. Apply when disease
first appears. Repeat at 7 to 14
day intervals as needed.
GREENHOUSE NON-FOOD CROP
(Ornamental Plants and Forest Trees)
/34022CA Azalea
/34058CA Firethorn
/34056CA Flowering Crabapple
/31126CA Iris
/34088CA Liguatrum
/31000CA Ornamental Herbaceous Plants
/35000CA Ornamental and/or Shade Trees
/34004CA Ornamental Woody Shrubs
/34118CA Rhododendron HybridsTCultivars
Refer to TERRESTRIAL NON-FOOD CROP, (Ornamental
Plants and Forest Trees), Azalea cluster, for use
and limitation information.
131
Issued: 8-r.9-84
11-099101-29
-------
/34147CA
Site and Pest
Orchids
/34120CA
Rose
EPA Index to Pesticide Chemicals
BENOMYL
Dosages and Tolerance. Use. Limitations
Formulation(s)
Refer to TERRESTRIAL NON-FOOD CROP, (Ornamental
Plants and Forest Trees), Orchids, for use and
limitation information.
Refer to TERRESTRIAL NON-FOOD CROP, (Ornamental
Plants and Forest Trees), Rose, for use and
limitation information.
AERIAL AND TANK MIX APPLICATIONS
9001500
AAAAAAA
Aerial Application
9900300
AAAAAAA
Tank Mix
Refer to
AGRICULTURAL CROPS
_ Almond, Apricot, Avocado, Banana,
Beans, Cabbage (seed crop), Carrots,
Celery, Cherry, Cucumber, Grapes,
Melons, Nectarine, Peach, Peanuts,
Pecan, Plum, Prune, Pumpkin, Rice,
Soybeans, Strawberry, Sugar Beets,
Summer Squash, Winter Squash
ORNAMENTAL PLANTS
(Ornamental Plants and Forest Trees)
Azalea, Firethorn, Flowering Crab-
apple, Iris, Llgustrum, Ornamental
Herbaceous Plants, Ornamental and/or
Shade Trees, Ornamental Voody Shrubs
and Vines, Rhododendron Hybrids/Cul-
tivars, Rose
Refer to
AGRICULTURAL CROPS
Apple, Peanuts
ORNAMENTAL PLANTS
(Including ground covers))
Turf
(Ornamental Turf
Ornamental
Issued: 8-29-84
11-099101-30
132
-------
EPA Index Co Pesticide Chemical*
BENOMYL
Listing of Registered Pesticide Products by Formulation
4095.0001 951 technical chemical
benemy1 (099101)
000352-00377
&OS0.0002 SOt formulation intermediate
benomyl (099101)
000352-00358
&001.1004
&001.5004
&001.5704
&001.6004
&001.9504
&000.0305
iC25.0006
&050.0006
1.1? granular
benomyl (099101)
000538-00132
1.51 granular
benomyl (099101)
001159-00183
1.571 granular
benomyl (099101)
000572-00256 __
1.61 granular
benomyl (099101)
000004-00201 007401-00407
1.951 granular
benomyl (099101)
000538-00066
0.31 pelleted/tableted
benomyl (099101) plua 2-(2-ethoxyethoxy)ethyl 2-benzimidazole carbamate
(115001) ' * •
007946-00006*
*.«. ..: ; jrrently unavailable for review"
25Z wettable powder
benomyl (099101)
034911-00027
501 wettable powder
benomyl (099101)
000004-00196 000004-00215
000192-00127
000352-00434
000769-00419
000904-00224
002169-00223
005887-00129
007478-00050
045084-00023
000352-00354
000557-01930
000802-00490
001159-00184
005481-00138
007401-00225
008590-00498
000016-00131
000352-00357
000572-00254
000829-00217
001386-00571
005719-00074
007478-00048
042057-00092
000070-00263
000352-00385
000731-00036
000869-00125
002125-00064
005719-00075
007478-00049
043410-00022
I»«u-d- 8-29-84
11-099101-31
133
-------
EPA Index Co Pesticide Chemicala
BZNOMY1
Listing of Registered Pescieidc Produces by Formulation (continued)
4203.0014 31 (0.251 Ib/gal) flovable concentrate
bcnooyl (099101)
008764-00017 046148-00002
4075.0014 75Z flowable concentrate (dry)
benomyl (099101)
000352-00396
4210.0015 101 (0.72 Ib/gal) soluble concentrate/liquid
beoomyl (099101)
008764-00027
9999999 State Label Registrations
AZ Reg. No.
004581-04385
CA Reg. No.
000909-04701 002935-06587 002915-06641 004581-04391
008764-07255 008764-07452 010965-09918* 010965-09919*
010965-09920* 011093-07129 035296-05825
*jacket currently unavailable for review
FL Reg,. No.
008517-03345 008517-03346 008517-03348
008764-09640 014775-10505 035222-07169
GA Reg. No.
004581-04401 •
HI Reg. No.
037843-08588
MD Reg. No.
004581-04400
NC Reg. No.
004581-04399
NJ Reg. No.
004581-04396
NY Reg. No.
038655-10456 038655-10469
OR Reg. No.
001871-08945
008764-07230
".sued: 8-29-34
11-099101-32
134
-------
EPA Index CO Pesticide Chemical*
BENOHYL
Lifting of Registered Pesticide Products by Formulation (continued)
PA Reg. No.
004581-04398
SC Reg. No.
004581-04397
TX Reg. No.
000557-09608 000557-09609 000557-09610 000557-09611
000557-09612 000557-09613 000557-09614 000557-09615
000557-09616 000557-09617 000557-09618 000557-09619
000557-09620 000557-09621 000557-09622
VA Reg. No.
004581-04402
WA Reg. No.
004581-04393 007404-06536
135
Issued: S-29 -r.4 II-099101-33
-------
EPA Index co Pesticide Chemical*
BENOMYL
Appendix A
Listing of Common Chemical Names Uaed on Che Entry
Common Name
Chemical
Code "
014504
(source)
mancoxeb (ISO)
EPA Acceptable
Common/Chemical Name
xinc ion and manganese ethylene bisthiocar-
baaaee 80Z, a coordination product of manganes
16Z, sine 21, ethylene bisthiocarbamate 62Z
136
Issued. .'-29-84
: 1-09. 101-3^
-------
EPA Index to Pesticide Chemical*
000802-00490
3ENOMYL
Appendix B
Listing by Sice/Pest and Sic«/Formul«tion/RegiJtr«tion Number
TERR£STIAL FOOD CROP
/03001AA Almond
FBADHCB Brovn rot blossom and twig blight (Monilinia)
(50Z WP)
000070-00263 000352-00354
(75Z F1C) (dry)
000352-00396
/04001AA Apple (prcharvest/foliar poat harvest)
FEAJVAG Apple scab (Venturia)
FMAUSAH Flyspeek (Schizothyrium)
FIBFBAW Fruit rot (Botrytis)
FIBFGAN Fruit rot (Cloeosporium)
FIBFPAO Fruit rot (Penicillium)
FGAWAC Overwintering scab (VenturiaJ.
FFACPDJ Powdery mildew (Podoaphaera)
FCAFGAL Sooty blotch (Cloeodes)
(50Z WP)
000070-00263 000352-00354 000572-00254
002169-00223 008590-00498 045084-00023
(75Z F1C) (dryj
000352-00396
/04001EA Apple (postharvest)
FIBFBAW Fruit rot (Botrytis)
FIBFGAN Fruit rot (Gloeosporium) •
FIBFPAO Fruit rot (Penieillium)
(50Z WP)
000070-00263 OOC352-00354
045084-00023
(3Z (0.25Z Ib/gal) F1C)
008764-00017
(73: F1C) (dry)
000352-00396
/05001EA Apricot (postharvest)
FICZQBB Postharvest fruit rots
(50Z WP)
000070-00263 000352-00354
043410-00022 045084-00023
(3Z (0.25Z Ib/gal) F1C)
008764-00017
002169-00223 043410-00022
002169-00223 005481-00138
137
Isaued: 3-29-84
11-099101-35
-------
EPA Index to Pesticide Oiemicals
BENOMYL
Appendix B
Listing by Site/Pest and Site/Formulation/Registration Number (continued)
Apricot (postharvest) (continued)
(75Z riC) (dry)
000352-00396
•
/05001AA Apricot (preharvest)
FBADMCB Brown rot blossom and twig blight (Monilinia)
FIALMCB Brown roe of fruit (Monilinia)
FEAJCCV Peach scab (Cladosporiua)
FFACQBB Powdery mildew
(50Z WP)
000352-00354 000572-00254 000802-00490 000869-00125
002169-00223 005481-00138 008590-00498 045084-00023
(75Z F1C) (dry)
000352-00396
/06001AA Avocado
FAAAGAP Anthracnose (Glomerella)
FMCBCBM Cercoapora leaf and fruit spot
FEAJSCB Scab (spot anthracnose) (Sphaceloma)
(50Z WP)
000070-00263' 000352-00354
«
(75Z F1C) (dry)
000352-00396
/06002AA Banana
FMBOCBM Sigatoka disease (Cercospora leaf spot) • ,
(50Z WP)
000070-00263 000352-00385
/06002EA Banana (poscharvest)
FIXAQBB Crown rot
FIBFQBB Surface molds
(50Z WP)
000070-0^263
/28001AA Beans
FHACBAW Gray mold (Botrytis)
FHANSAQ White mold (Sclerotinia)
(50Z WP)
000070-00263 000192-00127
000731-00036 000802-00490
042057-00092 045084-00023
000352-00354
000904-00224
000572-00254
005719-00075
(75Z F1C) (dry)
000352-00396
138
Issued: 8-29-84
IT-09r101-36
-------
/01002AA
FIBFBAW
FIBFPAQ
FFACSCO
/01009AA
FAAAGAN
FBADBAW
FIBMMCB
/01003AA
FIBFBAW
FIBFPAO
FFACSCO
/13007SA
FICXSAQ
/28073AA
FHANSAQ
/13002AA
FBAMCBM
FBASSBL
\
EPA Index Co Pesticide Chemicals
BENOKYL
Appendix B
Liating by Site/PesC and Siee/Formulacion/Regiscracion Number (continued)
Blackberry
Fruic roe (Bocrycia)
Fruic roc (Penicillium)
Powdery mildew (Sphaerocheca)
(SOZ WP)
000070-00263 000192-00127 000352-00354
042057-00092
(75Z F1C) (dry)
000352-00396
Blueberry
Anchracnose (leaf spoc) (Cloeosporium)
Bocrycia blossom blighc
Mummy berry (Monilinia vacciniicoryabosi
(SOZ WP)
000070-00263 000352-00354__
(75Z F1C) (dry)
000352-00396
Boysenberry
Fruie roc (Bocrytis)
Fruie roe (Penicillium)
Powdery mildew (Sphaerocheca)
(50Z WP)
000070-00263 000192-00127 000352-00354
(75Z F1C) (dry)
000352-00396
Cabbage (seed crop)
Scleroeinia scalk roc
(SOZ WP)
000352-00354
(75Z F1C) (dry)
OC0352-00396
Carrots
White roc (Scleroeinia)
(SOZ WP)
000352-00354
042057-00092
Cele
Early blighc (Cercoapora)
Lace blighc (Sepcoria)
(SOZ WP)
000070-00263
Lsaued: 8-29-84
000192-00127 000352-00354
11-09.101-37
139
-------
EPA Index to Pesticide Chemical*
BENOMYL
Appendix B
Lifting by Site/Peat and Site/Formulation/Regiatration Number (continued)
Celery (continued)
(75Z F1C) (dry)
000352-00396
002169-00223 005481-00138
/05002EA Cherry (postharveat)
FZCZQBB Poatharveat fruit rota
(50Z WP)
000070-00263 000352-00354
043410-00022 045084-00023
(3Z (0.25Z Ib/gal) FlC)
008764-00017
(75Z FlC) (dry)
000352-00396
/05002AA Cherry (preharveat/foliar poat harvest)
FBADMCB Brown rot blossom and tvig blight (Monilinia)
FZALMCB Brown rot of fruit (Monilinia)
FMBCCDJ Cherry leaf apot (Coccomycea)
FEAJCCV Peach acab (Cladoaporium)
FFACQBB Powdery mildew
(50Z WP)
000352-00354 000572-00254 000802-00490 002169-00223
005481-00138 008590-00498 045084-00023
(75Z FlC) (dry)
000352-00396
• «
/02000AA Citrua Fruits
FIBFPAO Blue mold (Penicillium italicum)
FMATCC3 Creasy spot (Mycosphaerella)
FIBFPAO Green mold (Penicillium digitatum)
FAABEAH Scab (apot anthracnoae) (Elainoe)
FICIQBB Stem-end rot
(50Z WP)
000070-00263 000192-00127• 000352-00354
(75Z FlC) (dry)
000352-00396
/02000EA Citrua Fruita (poatharveat)
FIBFPAO Blue mold (Penicillium italicum)
FIBFPAO Green mold (Penicillium digitatum)
FICIQBB Stem-end rot
(50Z WP)
000070-00263 000352-00354 043410-00022
140
Issued: 8-29-34
11-099101-38
-------
/10010AA
FAAACDP
FBAQMCO
FFACEBJ
FMBCCZK
/01004AA
FZBFBAW
FIBFPAO
FFACSCO
/01014AA
FIADMAV
FIBFCBG
FIARBAW
FFACUAB
EPA Index Co Pesticide Chemicals
BENOMYL
Appendix B
Listing by Site/Pest *nd Site/Formulation/Regiatration Number (continued)
Citrus Fruits (po« thai-vest) (continued)
(32 (0.252 Ib/gal) F1C)
008764-00017 046148-00002
(752 F1C) (dry)
000352-00396
•^
(102 (0.72 lb/g«l) SC/L)
008764-00027
Cucumber
Anthracnose (Colletotrichum)
Gummy stem blight (Mycosphaerella)
Powdery mildew (Erysiphe)
Target leaf spot (Corynespora) (on cucumbers)
(502 WP) __
000192-00127 000352-00354 000352-00434
000731-00036 000869-00125 000904-00224
005481-00138 005719-00075 042057-00092
000070-00263
000572-00254
002169-00223
045084-00023
(752 FIG) (dryl
000352-00396
«
Dewberry
Fruit rot (Botrytis)
Fruit rot (Penicillium)
Powdery mildew (Sphaerotheca) •
(502 WP)
000070-00263 000352-00354 042057-00092
(752 FiC) (dry)
000352-00396
Grapes
Bitter rot (Melanconium)
Black rot (Guignardia)
Botrytis bunch rot
Powdery mildew (Uncinula)
(502 WP)
000070-00263 000352-00354
008590-00498
(752 FIC) (dry)
000352-00396
141
Issued: 8-29-84
11-099101-39
-------
/01005AA
FIBFBAW
FIBFPAO
FFACSCO
/03007AA
FBAOBAW
/06007AA
FAAACAP
AOOOIAA
FAAACDP
FBAQMCO
FFACEBJ
/16003AA
FGAFVAK
EPA Index eo Pesticide Chemicals
BENOMYL
Appendix B
Listing by Site/Pest »nd Site/Formulation/Registration Number (continued)
Loganberry
Fruit rot (Botrytis)
Fruit rot (Penicillium)
Powdery mildew (Sphacrotheca)
(50X WP)
000070-00263 000352-00354 042057-00092
(75X F1C) (dry)
000352-00396
Maeadamia Hut
Bo cry t is blossom blight
(50Z WP)
000070-00263 000352-00354
(75Z F1C) (dry)
000352-00396 _
Mango
Anthracnose (flower and twig blight/fruit spot) (Clomerella)
(50Z MP)
000070-00263 000352-00354
(751 F1C) (dry)
000352-00396
Melons
Anthracnose (Colletotrichum)
Gummy stem blight (Mycosphaerella) • ,
. Powdery mildew (Erysiphe)
(502 WP)
000070-00263 000192-00127
000731-00036
005719-00075
000572-00254
005481-00138
000352-00354
000904-00224
042057-00092
000352-00385
002169-00223
045084-00023
(75Z F1C) (dry)
000352-00396
Mushrooms
Verticillium spot (dry bubble)
(50Z UP)
000070-00263 000352-00354
(75Z F1C) (dry)
000352-00396
Issued: 6-29-84
142
II-0°910l-40
-------
EPA Index Co Pesticide Chemicals
/OS003EA
FZCZQBB
/05003AA
FBADMCB
FIALMCB
FEAJCCV
FFACQBB
/OS004EA
FICZQBB
/OS004AA
FBADMCB
FIALMCB
FEAJCCV
FFACQBB
BENOHYL
Appendix B
Listing by Sice/Pest and Site/Formulation/Registration Number (continued)
002169-00223 005481-00138
Nectarine (postharvest)
Postharvest fruit rots
(50Z WP)
000070-00263 000352-00354
043410-00022 045084-00023
(3Z (0.25Z Ib/gal) FlC)
008764-00017
(75Z FlC) (dry)
000352-00396
Nectarine (preharvest)
Brown rot blossom and twig blight (Monilinia)
Brown rot of fruit (Monilinia)
Peach scab (Cladosporiun) _
Powdery mildew
(50Z WP)
000352-00354 000802-00490 000869-00125 002169-00223
005481-00138 008590-00498 045084-00023
(75Z FlC) (dry)
000352-00396 '
002169-00223 005481-00138
Peach (postharvest)
Postharvest fruit rots
(50Z WP)
000070-00263 000352-00354
043410-00022 045084-00023
(31 (0.25Z Ib/gal) FlC)
008764-00017
(75Z FlC) (dry)
000352-00396
Peach (preharvest)
Brown rot blossom and twig blight (Monilinia)
Brown rot of fruit (Monilinia)
Peach scab (Cladosporium)
Powdery mildew
(50Z WP)
000352-00354 000572-00254 000802-00490 000869-00125
002169-00223 005481-00138 008590-00498 045084-00023
(75Z FlC) (dry)
000352-00396
143
Issued: 6-29-34
11-099101-41
-------
EPA Index to Pesticide Chemical*
BENOMYL
Appendix B
Listing by Site/Pest and Site/Formulation/Registration Number (continued)
045084-00023
002169-00223 043410-00022
/280154AA Peanuts
FMBCCBM Leaf spot (Cercoapora)
(50Z WP)
000352-00354 002169-00223
•
(75Z FIG) (dry)
000352-00396
/04003EA Pear (postharvest)
FIBFBAW Fruit rot (Botrytis)
FIBFGAN Fruit rot (Gloeosporium)
FIBFPAO Fruit rot (Penieillium)
(502 WP)
000070-00263 000352-00354
045084-00023
(3Z (0.25Z Ib/gal) F1C)
008764-00017
(75Z F1C) (dry)
000352-00396
»
/04003AA Pear (preharvest/foliar postharvest)
FMAUSAH FTyspeck (Schizothyrium)
FIBFBAW Fruit rot (Botrytis)
FIBFGAN Fruit rot (Gloeosporium)
FIBFPAO Fruit rot (Penieillium)
FGAWAG Overwintering scab (Venturia)
FEAJVAG Pear scab (Venturia) « ,
FFACPOJ Powdery mildew (Podosphaera)
?CAfCn_ Sooty blotch (Cioeoces)
(50Z WP)
000070-00263 000192-00127 000352-00354 000572-00254
002169-00223 045084-00023
(75Z F1C) (dry)
000352-00396
/03008AA Pecan
FMBCCBM Brown leaf spot (Cercospora)
FMASMCO Downy leaf spot (Mycosphaerella)
FGAKQBB Fungal leaf scorch
FMBDGAT Liver spot (Gnomonia)
FEAJCCV pecan scab (Cladosporium)
FFACMBT Powdery mildew (Microsphaera)
(50Z WP) *
000070-00263 000192-00127 000352-00354 002169-00223
045084-00023
144
Issued: 8-29-84
11-099101-42
-------
/06013AA
PICVTAK
/06013EA
FIBFTAK
/05005EA
FICZQBB
/0500SAA
FBADNCB
FZALMCB
FEAJCCV
FFACQBB
EPA Index to Pesticide Chemicals
BENOMYL
Appendix B
Lifting by Site/Pest *nd Site/Formulation/Regiatration Number (continued)
Pecan (continued)
(75Z FIC) (dry)
000352-00396
Pineapple
Butt rot (Thielaviopsis)
(50Z UP)
000070-00263 000352-00354
(75X PIC) (dry)
000352-00396
Pineapple (postharvest)
Thielaviopsis rot
(502 VP)
000070-00263 000352-00354 —
(75Z PIC) (dry)
000352-00396
Plua (poatharvcst)
Postharvest fruit rota
(50Z WP)
000070-00263 000352-00354
043410-00022 045084-00023
002169-00223 005481-00138
(3Z (0.2SZ Ib/gal) PIC)
008764-0001-7 ,
(75Z PIC) (dry)
000352-00396
Plum (preharvest)
Brown rot blossom and tvig blight (Monilinia)
Brown rot of fruit (Monilinia)
Peach scab (Cladoaporium)
Powdery mildew
(50Z WP)
000070-00263 000352-00354
000869-00125 002169-00223
045084-00023
(75Z PIC) (dry)
000352-00396
000572-00254
005481-00138
000802-00490
008590-00498
145
J-.su.d: 8-25-84
1-099101-V3
-------
/05006EA
FICZQBB
/05006AA
FBADMCB
FIALMCB
FEAJCCV
FFACQBB
/10011AA
FAAACDP
FBAQHCO
FFACEBJ
/o;oc A
FIBF3AW
FIBFPAO
FFACSCO
EPA Index Co Pesticide Chemicals
BENOKYL
Appendix B
Listing by Sict/Pesc and Site/Formulation/Regiatration Number (continued)
002169-00223 005481-00138
Prune (postharvest)
Postharvest fruit rots
(50Z WP)
000070-00263 000352-00354
043410-00022 045084-00023
(3Z (0.25Z Ib/gal) FIG)
008764-00017
(75Z F1C) (dry)
000352-00396
Prune (preharvest)
Brown rot blossom and twig blight (Monilinia)
Brown rot of fruit (Monilinia)
Peach scab (Cladosporium) __
Powdery mildew
(50Z WP)
000070-00263 000352-00354 000802-00490 002169-00223
008590-00498
(75Z F1C) (dry?
000352-00396
Pumpkin
Anthracnose (Colletotrichum)
Gumoy stem blight (Mycosphaerella)
Powdery mildew (Erysiphe)
(50Z WP) . .
000192-00127 000352-00354 000572-00254
000070-00263
005719-00075
(75Z F1C) (dry)
000352-00396
Raspberry
Truit rot (Bocrytis)
Fruit rot (Penicillium)
Powdery mildew (Sphaerotheca)
(50Z WP)
000070-00263 000192-00127 000352-00354
(75Z F1C) (dry)
000352-00396
042057-00092
146
Issued: 8-29-.
11-099.01-44
-------
EPA Index to Pesticide Chemicals
/28072AA
FMAHPCR
FICHQBB
/28023AA
FAAAGAP
FBAYDAP
FMAVCBM
FKACCBH
FMAJSBL
/28023BA
FBAYDAP
/01016AA
FAAACOP
FHACBAW
FBATDAH
FGAKDBS
FMBCMCO
FFACSCO
/010160A
FUXBAW
FMBCMCO
BENOMYL
Appendix B
Listing by Site/Pest and Site/Foraulation/Registration Number (continued)
Rice
Blast (rotten neck) (Piricul*ri«)
Stem rot
(501 WP)
000352-00354
(75Z F1C) (dry)
000352-0039$
•
Soybeans
Anthracnose (Glomerella)
Diaporthe pod and stem blight
Frogeye leaf spot (Cercospora)
Purple seed stain (Cercospora)
Septoria brown rot
(50Z WP)
000352*00354 ~~
(75Z F1C) (dry)
000352-00396
Soybeans (seed crop)
Diaporthe pod and stem blight
(50Z WP)
000352-00354
Strawberry
Anthracnose (Colletotrichum)
Gray mold (Botrytis) • .
Leaf blight (Dendrcphoma)
Leaf scorch (Diplocarpon)
Leaf spot (Mycosphaereiia)
Powdery mildew (Sphaerotheca)
(50Z WP)
00^070-00263 000192-00127
Or •:69-00223 008590-00498
000352-00354
042057-00092
000802-00490
045084-00023
(75Z F1C) (dry)
000352-00396
Strawberry (transplants)
Botrytis crown rot
Leaf spot (Mycosphaereiia)
(50Z WP)
000070-00263 000352-00354
(75Z F1C) (dry)
000352-00396
147
Issued: 8-29-84
:i-099101-45
-------
/28020AA
FMBCCBM
/25003AA
FIBSCBI
/10013AA
FAAACDP
FBAQMCO
FFACEBJ
/1100SAA
FHACBAW
FHACCCV
FMBCCEM
FMAEPBS
FICHSAQ
EPA Index Co Pesticide Chemicals
BENOMYL
Appendix B
Listing by Sice/Peat and Site/Foraulation/Registration Number (continued)
Sugar Beets
Leaf spot (Cercospora)
(50Z VF)
000352-00354
(75X F1C) (dry)
000352-00396
Sugarcane
Pineapple disease (Ceratocystis)
(50Z WP)
00.0352-00354
(75Z F1C) (dry)
000352-00396
Summer Squash
Anthracnose (Colletotrichun)
Guomy stem blight (Mycosphaerella)
Powdery mildew (Erysiphe)
(50Z WP)
000070-00263 * 000192-00127
000731-00036 000869-00125
005481-00138 005719-00075
000352-00354
000904-00224
042057-00092
000572-00254
002169-00223
045084-00023
(75Z F1C) (dry)
000352-00396
Tomato
Gray mold (Botrytis)
Leaf mold (Cladosporium)
L=.-f spec (Cercospcra)
Phoma black spot of leaf
Timber rot (Sclerotinia)
(50Z WP)
000070-00263 CrH92-00127
000869-00125 00*169-00223
045084-00023
(75Z F1C) (dry)
000352-00396
000352-00354
005719-00075
000572-00254
042057-00092
148
Issued: 8-29-84
.1-099101-'c
-------
/1001AAA
FAAACDP
FBAQMCO
FFACEBJ
/34022AA
FBADOAV
/31083AA
F1APFAK
FIAPPAO
/31093AA
FIAFFAK
FIAPPAO
CPA Index to Pesticide Chemicals
BENOKYL
Appendix B
Listing by Site/Pest and Site/Formulation/Registration Number (continued)
Winter Squash
Anthracnose (Collecotriehuo)
Gummy stea blight (Mycosphaerella)
Powdery mildew (Erysiphe)
(50Z WP)
000070-00263 000192-00127
000731-00036 000869-00125
005481-00138 005719-00075
000352-00354
000904-00224
042057-00092
000572-00254
002169-00223
045084-00023
(75Z PIC) (dry)
000352-00396
TERRESTIAL NON-FOOD CROP
(Ornamental Plants and Forest Trees)
Azalea
Ovulinia petal blight (of azalea and rhododendron)
(50Z WP)
000004-00196 000016-00131 000070-00263 000192-00127
000352-00354 000352-00357 005481-00138 005719-00074
005719-00075 008590-00498
(75Z F1C) (dry)
000352-00396
Daffodil
Baaal rot (Fusarium) »
Penieilliua rot
(50Z WP)
000004-00196
000352-00357
000904-00224
043410-00022
000016-00131
000731-00036
005481-00138
OCOC70-00263
000802-00490
005887-00129
OOC332-00354
000829-00217
D08590-00498
(75Z F1C) (dry)
000352-00396
Easter Lily
Basal rot (Fusarium)
Penieillium rot
(50Z WP)
000004-00196
000352-00357
000904-00224
043410-00022
000016-00131
000731-00036
005481-00138
000070-00263
000802-00490
005887-00129
000352-00354
000829-00217
008590-00498
149
Issued: 8-29-84
11-099101-47
-------
/35049AA
FGAGCBI
/34058AA
FEAJFAM
/35056AA
FEAJVAG
/31111AA
FIAPFAK
FIAPPAD
EPA Index to Pesticide Chemicals
3LHOMYL
Appendix B
Listing by Site/Pest and Site/Formulation/Registration Number (continued)
Easter Lily (continued)
(75* F1C) (dry)
000352-00396
Dutch Elm Disease (Ceratocystis ulmi)
(50* WP)
000004-00215 000352-00354
Firethorn
Scab (Fusicladiua) (of firethorn)
(50* WP)
000004-00196 000016-00131 000070-00263
000352-00354 000352-00357 005481-00138
005719-00075 008590-00498
(75* F1C) (dry)
000352-00396
Flowering Crabapple
Scab (Venturia) (of flowering crabapple)
(50* WP)
000004-00196 000016-00131 000070-00263
000352-00354 000352-00357 005481-00138
005719-00075 008590-00498
(75* F1C) (dry)
000352-00396
Gladiolus
Basal rot (Fusariua)
Penicillium rot
(50* WP)
000004-00196 000016-00131
000352-00357
000904-00224
000192-00127
005719-00074
000192-00127
005719-00074
000731-00036
005481-00138
000070-0026*
000802-00«r
005887-00129
000352-00354
000829-00217
008590-00498
043410-00022
(751 F1C) (dry)
000352-00396
150 )
Issued: 8-29-84
11-099101-48
-------
EPA Index co Pesticide Chemicals
/31126AA
FIAPFAK
FIAPPAD
FMBCDBD
/34088AA
FKBCCEK
/31147AA
FAAACDP
FAAACAP
FGATFAK
FHBCCBM
FMBCPCE
FBAD3AW
FICBRAM
BENOMYL
Appendix B
Listing by Siee/Pesc and Sitt/Formulation/Registracion Number (continued)
Iris
Basil roe (Fusarium)
Penieilliua rot
Leaf spot (Didymellina) (of iri«)
(50Z WP)
000016-00131
000352-00357
000904-00224
005887-00129
000004-00196
000352-00354
000829-00217
005719-00075
000070-00263
000731-00036
005481-00138
008590-00498
000192-00127
000802-00490
005719-00074
043410-00022
000070-00263
005481-00138
(75X PIC) (dry)
000352-00396
Liguscrum
Leaf spot (Corynespora)
(50Z WP)
000004-00196 000016-00131-
000352-00354 000352-00357
005719-00075
(75Z FIG) (dry)
000352-00396-
Orchids
American anthracnose (Colletotrichua)
European anthracnose (Gloeosporiua)
Fusarium wile
Leaf spot (Cercospora)
Leaf spoe (Phylloseicta)
Petal blighe (Botrytis)
Rhizoctonia root roe
(502 WP)
007478-00048
000192-00127
005719-00074
151
Issued: 6-29-84
II-099101-»9
-------
Isdex to Pesticide Chemicals
/31000AA
FBAAACC
FBACBAW
FICHBAW
FICYBAW
FICHFAK
FICYFAK
FMBCCBM
FMBCRAD
FMBCSBL
FFACQBB
FICHBAM
FICYRAM
FICHSAQ
FICYSAQ
/35000AA
FAAAQBB
FLAACFO
FMBCCBM
FMBCZAW
FMBCSBL
FBAAPBU
FIAATAK
BENOMYL
Appendix B
Listing by Sice/Feat and Site/Formulation/Regiatration Number (continued)
Ornamental Herbaceous Plants
Ascocnyta blight
Boerytis gray mold
Botrytis stem, crown and root rots
Fusarium stem, crown and root rots - .
Leaf spot (Cercospora)
Leaf spot (Ramularia)
Leaf spot (Septoria)
Powdery mildew
Rbizoctonia stem, crown and root rots
Sclerotinia stem, crown and root rots
(25Z WP) —
034911-00027
000016-00131
000352-00357
000769-00419
001159-00184
005719-00074
008590-00498
(50Z WP)
000004-00196
000352-00354
000731-00036
000904-00224
005481-00138
007401-00225
(75Z F1C) (dry)
000352-00396
Ornamental and/or Shade Trees
Anthracnose
Cylindrocladium rot
Leaf spot (Cercospora)
Leaf spot (Entomosporium)
Leaf spot (Septoria)
Phomopsis blight
Thielaviopsis rot
(50Z WP)
000004-00196 000016-00131
000352-00354 000352-00357
005719-00075 008590-00498
(75Z FIC) (dry)
000352-00396
000070-00263
000557-01930
000802-00490
001386-00571
005719-00075
042057-00092
000192-00127
000572-00254
000829-00217
002125-00064
005887-00129
045084-00023
000070-00263
005481-00138
000192-00127
005719-00074
152
Issued: 8-29-84
11-099101-50
-------
EPA Index to Pesticide Oiesicala
BENOMYL
Appendix B
Lilting by Sice/Pest and Sitc/Foraulation/Rtgiatration Number (concinued)
/33008AA Ornamental Turf
FBAHRAM Brown patch (Rhizoctonia)
FMAQSAQ Dollar spot (Sclerolinia)
FBAAFAK Fuaarium blight (Fuaarium roaeum and F. tricinctum)
FHAJFAK ' Fuaarium patch (snow mold) (Fuaarium nivalc)
FLAUUAL Stripe smut (Uatilago)
(1.1Z G)
000538-00132
(1.5Z G)
001159-00183
(1.571 G)
000572-00256
(1.6Z G)
000004-00201
(1.95Z G)
000538-00066
(25Z WP)
034911-00027
(50Z WP)
000004-00196
000192-00127
000731-00036
000869-00125
002125-00064
008590-00498
007401-00407'
000004-00215
000352-00357
000769-00419
000904-00224
005719-00075
042057-00092
000016-00131
000557-01930
000802-00490
001159-00184
007401-00225
045084-00023
000070-00263
000572-00254
000829-00217
001386-00571
007478-00050
153
Is»u:d: 8-29-84
11-099101-51
-------
EPA Iu.dex is Pesticide Chemicals
/34004AA
FAAAQBB
FHACBAW
FIAACPO
FMBCCBH
FMBCEAW
FBAAPBU
FFACQBB
FIAATAK
/34118AA
FBADOAV
734120AA
FMAEDBS
FFACSCO
BENOMYL
Appendix B
Listing by Sitt/Pest and Site/Foroulation/Regiatration Number (continued)
Ornamental Woody Shrubs
Anthracnose
Botrytis gray mold
Cylindrocladium rot
Leaf spot (Cercospora)
Leaf spot (Entomosporium)
Phonopsis blight
Powdery mildew
Thielaviopsis rot
(251 WP)
034911-0002?
(50Z WP)
000004-00196
000352-00354
000731-00036
000904-00224
005481-00138
007401-00225
(75Z F1C) (dry)
000352-00396
000016-00131
000352-00357
000769-00419.
001159-00184
005719-00074
008590-00498
000070-00263
000557-01930
000802-00490
001386-00571
005719-00075
042057-00092
000192-00127
000572-00254
000829-00217
002125-00064
005887-00129
045084-00023
Rhododendron Hybrids/Cultivars
Ovulinia petal blight (of azalea and rhododendron)
(502 WP)
000004-00196 000016-00131 000070-00263 . 000192-00127
000352-00354 000352-00357 005481-00138 005719-00074
005719-00075 008590-00498 * .
(75Z F1C) (dry)
000352-00396
Rose
Black spot (Diplocarpon)
Powdery mildew (Sphaerotheca)
f M *•» **•» %
034911-00027
(50Z WP)
000004-00196
000352-00354
000731-00036
000869-00125
002125-00064
005887-00129
042057-00092
000016-00131
000352-00357
000769-00419
000904-00224
005481-00138
007401-00225
045084-00023
000070-00263
000557-01930
000802-00490
001159-00184
005719-00074
007478-00049
000192-00127
000572-00254
000829-00217
001386-00571
005719-00075
008590-00498
154
S-29-84
11-099101-52
-------
/31025AA
F1APFAK
FIAPFAO
EPA Index to Pesticide Chemical*
BENOMYL
Appendix B
Lifting by Site/Pest and Site/Formulation/Registration Number (continued)
Rose (continued)
(75X F1C) (dry)
000352-00396
Tulips
Basal roc (Fusariua)
Fenieillium rot
(50Z WP)
000004-00196
000352-00357
000904-00224
043410-00022
(75Z FIG) (dry)
000352-00396
000016-00131
000731-00036
005481-00138
000070-00263
000802-00490
005887-00129
000352-00354
000829-00217
008590-00498
GREENHOUSE FOOD CROP
f
(Agricultural Cropa)
/11005CA Tomato (greenhouse)
FHACBAW Gray mold (Botrytis)
FHAGCCV Leaf mold (Cladosporiua)
FMBCCBM Leaf spot (Carcospora)
FMAEPBS Phoma black spot of leaf
FICHSAQ Timber rot (Sclerotinia)
(5T* W?)
000070-00263 000352-00354
(75Z FiC) (dry)
000352-00396
000572-00254 005719-00075
CREENHOUS; NOM-FOOD CROP
(Ornanental Plants and Forest Trees)
/34022CA Azalea
FBADOAV Ovulinia petal blight (of azalea and rhododendron)
(50Z WP)
000004-00196 000016-00131 000070-00263 000352-00354
000352-00357 005719-00074 005719-00075 008590-00498
(75Z FIC) (dry)
000352-00396
155
-------
/34058CA
FEAJFAM
/35056CA
FEAJVAG
/31126CA
FMBCDBD
/34088CA
FMBCCEK
/31147CA
FAAACDP
FAAAGAP
FGATFAK
FMBCCBM
FMBCPCE
FBADBAW
FICBRAM
SPA Index to Pesticide Chemical'
BENOMYL
Appendix B
Listing by Site/Pest and Site/Fonaulation/Registration Number (continued)
Firethorn
Scab (Fuaicladium) (of firethora)
(SOZ WP)
000004-00196 000016-00131 000070-00263
000352-00357 005719-00074 005719-00075
y
(75Z F1C) (dry)
000352-00396
Flowering Crabapple
Scab (Venturia) (of flowering crabapple)
(50Z WP)
000004-00196 000016-00131 000070-00263
000352-00357 005719-00074 005719-00075
(75Z F1C) (dry) _
000352-00396
Leaf spot (Didymellina) (of iris)
(50Z WP)
000004-00196 000016-00131 000070-00263
000352-00357 005719-00074 005719-00075
(75Z F1C) (dry)
000352-00396
Ligustrum
Leaf spot (Corynespora) *
000352-00354
008590-00498
000352-00354
008590-00498
000352-00354
000016-00131
005719-00074
000070-00263
005719-00075
000004-00196
000352-00357
(75Z F1C) (dry)
000352-00396
Orchids
American anthracnose (Colletotrichum)
European anthracnose (Gloeosporium)
Fusariua wilt
Leaf spot (Cercospora)
Leaf spot (Phyllosticta)
Petal blight (Botrytis)
Rhizoctonia root rot
(50Z WP)
007478-00048
000352-00354
156
Issued: 8-2,-84
11-099101-54
-------
/31000CA
FBAAACC
FHACBAU
FICHBAU
FICYBAW
FICHFAK
FICYFAK
FMBCCBM
FMBCRAD
FMBCSBL
FFACQBB
FICHRAM
FICYRAM
FICHSAQ
FICYSAQ
/35000CA
FAAAQBB
FIAACFO
FMBCCBM
FMBCEAW
FMBCSBL
FBAAFBU
FIAATAK
EPA Index to Pesticide Chemicals
BENOMYL
Appendix B
Listing by Sice/Pest *nd Site/Formulation/Registration Number (continued)
Ornamental Herbaceous Plants
Ascochyta blight
Botrytis gray sold
Botrytij stea, crown and root rots
Fusariua stem, crown and root rots
Leaf spot (Ccreospora)
Leaf spot (Ramularia)
Leaf spot (Septoria)
Powdery mildew
Rhizoctonia stem, crown and root rots
Sclerotinia stem, crown and root rots
(251 UP)
034911-00027 —
000016-00131
000557-01930
001159-00184
005719-00075
045084-00023
(50Z UP)
000004-00196
000352-00357'
000904-00224'
005719-00074
008590-00498
(75Z F1C) (dry)
000352-00396
Ornamental and/or Shade Trees
Anthracnose
Cylindrocladium rot
Leaf spot (Cercospora)
Leaf spot (Entoaosporiua)
Leaf spot (Septoria)
Fbomopsis blight
Thielavioosi • roc
(50Z UP)
000004-00196 000016-00131
000352-00357 005719-00074
(75Z FiC) (dry)
000352-00396
000070-00263
000572-00254
001386-00571
005887-00129
000352-00354
000731-00036
002125-00064
007401-00225
000070-00263 000352-00354
005719-00075 008590-00498
157
Issued: 8-29-84
11-099'11-35
-------
EPA Index Co Pesticide Chemicals
/34004CA
FAAAQBB
FHACBAW
FIAACFO
FMBCCBM
FMBCEAW
FBAAPBU
FFACQBB
FIAATAX
/34118CA
FBADOAV
/34120AA
FMAEDBS
FFACSCO
BENOMYL
Appendix B
Listing by Sice/Pest *nd Sice/Foraulation/Registration Number (continued)
Ornamental Woody Shrubs
Anthracnose t
Botrytis gray mold
Cylindrocladium roe
Leaf spot (Cercoapora)
Leaf spot (Encomosporiua)
Phonopsis blight
Powdery mildew
thielaviopsis rot
(25Z WP)
034911-00027
000016-00131 000070-00263
000557-01930 000572-00254
001159-00184- 001386-00571
005719-00075 005887-00129
045084-00023
000352-00354
000731-00036
002125-00064
007401-00225
(50Z WP)
000004-00196
000352-00357
000904-00224
005719-00074
008590-00498
(75Z F1C) (dry)
000352-00396-
Rhododendron Hybrids/Cultivars
Ovulinia pecal blight (of azalea and rhododendron)
(50Z WP)
000004-00196 000016-00131 000070-00263 000352-00354
000352-00357 005719-00074 005719-00075 008590-00498
(75Z F1C) (dry) - * •
000352-00396
Rose
Black spot (Diplocarpon)
Powdery mildew (Sphaerotheca)
(25Z WP)
034911-00027
(50Z WP)
000004-00196
000352-00357
000869-00125
002125-00064
007401-00225
(75Z F1C) (dry)
000352-00396
000016-00131
000557-01930
000904-00224
005719-00074
008590-00498
000070-00263
000572-00254
001159-00184
005719-00075
045084-00023
000352-00354
000731-00036
001386-00571
005887-00129
158
Issued: 8-29-84
II-099101-SA
-------
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-------
IV. BIBLIOGRAPHY APPENDICES
Guide to Bibliography
Bibliography
160
-------
^ Appendix II-l
' Guide to Use of This Bibliography
1. CONTENT OP BIBLIOGRAPHY. This bibliography contains
citations of all studies considered relevant by EPA In
arriving at the positions and conclusions stated elsewhere
In the Standard. Primary sources for studies In this
bibliography have been the body of data submitted to EPA
and Its predecessor agencies In support of past regulatory
decisions. Selections from other sources Including the
published literature, In those Instances where they have
been considered, will be Included.
2. UNITS OP ENTRY. The unit of entry In this bibliography
Is called a "study." In the case of published materials,
this corresponds closely to an article. In the case of
unpublished materials submitted to the Agency, the Agency
has sought to Identify documents at a level parallel to
the published article from_within the typically larger
volumes In which they were submitted. The resulting
"studies" generally have a distinct title (or at least a
single subject), can stand alone for purposes of review,
and can be described with a conventional bibliographic
citation. The Agency has attempted also to unite basic
documents and- commentaries upon them, treating them as a
single study.
3. IDENTIFICATION OP ENTRIES. The entries in this bibliography
are sorted numerically by "Master Record Identifier," or
MRID, number. This number is unique to the citation, and
should be used at any time specific reference is required.
It Is not related to the six-digit "Accession Number"
which has been used to identify volumes of submitted
studies; see paragraph 4(d)(4) below for a further explana-
tion. In a few cases, entries added to the bibliography
late in the review may be preceded by a nine-character
temporary identifier. These entries are listed after
all MRID entries. This temporary Identifier number is
also to be used whenever specific reference is needed.
U. FORM OP ENTRY. In addition to the Master Record Identifier
(MRID), each entry consists of a citation containing
standard elements followed, in the case of material
submitted to EPA, by a description of the earliest known
submission. Bibliographic conventions used reflect the
standards of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
161
-------
a. Author. Whenever the Agency could confidently identify
one, the Agency has chosen to show a personal author.
When no individual was identified, the Agency has
shown an identifiable laboratory or testing facility
as author. As a last resort, the Agency has shown
the first submitter as author.
b. Document Date. When the date appears as four digits
with no question marks, the Agency took it directly
from the document. When a four-digit date is followed
by a question mark, the bibliographer deduced the
date from evidence in the document. When the date
appears as (19??), the Agency was unable to determine
or estimate the date of the document.
c. Title. In some cases, it has been necessary for
Agency bibliographers to create or enhance a document
title. Any such editorial insertions are contained
between square brackets.
d. Trailing Parentheses.— For studies submitted to the
Agency in the past, the trailing parentheses include
(in addition to any self-explanatory text) the fol-
lowing elements describing the earliest known submission:
(1) Submission Date. The date of the earliest known
submission appears immediately following the word
"received."
(2) Administrative Number. The next element,
immediately following the word "under," is the
registration number, experimental use permit
number, petition number, or other administrative
number associated with the earliest known submission.
(3) Submitter. The third element is the submitter,
following the phrase "submitted by." When
authorship is defaulted to the submitter, this
element Is omitted.
d) Volume Identification (Accession Numbers). The
final element in the trailing parentheses
identifies the EPA accession number of the volume
in which the original submission of the study
appears. The six-digit accession number follows
the symbol "CDL," standing for "Company Data
Library." This accession number is in turn
followed by an alphabetic suffix which shows the
relative position of the study within the volume.
For example, within accession number 123^56, the
first study would be 123J*56rA; the second, 123^56-
B; the 26th, 123*56-3; and the 27th, 123^56-AA. | £2
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MR ID CITATION
00003806 E.I. du Pont de Nemours 4 Company (1973) Data Supporting the Use of
Benlate(R) Benomyl Fungicide on Cucurbits. (Unpublished study -
received Jul 20, 1973 under 352-354; CDL:008909-A)
00026042 Gauer, W.O.; Haglund, W.A.; Archer, T.E. (1978) Summary bf Residue
Data for Benomyl In or on Spinach: PR No. 761. (Unpublished
study received Dec 19, 1979 under OE2309; prepared 1n coopera-
tion with Washington State Univ., Northwestern Washington Re-
search and Extension Unit, Dept. of Plant Pathology and Univ. of
California, Dept. of Environmental Toxicology, submitted by In-
terregional Research Project No. 4, New Brunswick, N.J.; CDL:
099156-A)
00030771 Hopkins, D.L.; Fennel1, J.J.; Amador, J.M.; et al. (1975) Data Sup-
porting the Use of Benlate(R) Benomyl Fungicide plus Man-
zate(R) 200 or Manzate(R) D as Tank Mixtures for the Control
of Certain Diseases ofJCucurblts. (Unpublished study Including
published data, received Jun 12, 1975 under 352-291; prepared
In cooperation with Univ. of Florida, Agricultural Research Cen-
ter at Leesburg and others, submitted by E.I. du Pont de Nemours
S Co., Wilmington. Del.; CDL:241809-A)
00035346 E.I. du Pont de Nemours & Company, Incorporated (1970) Results of
Tests on the Amount of Residue Remaining on Treated Crops: Ben-
omyl. (Unpublished study received Jul 1, 1970 under 1F1010;
CDL:091750-A)
00035358 E.I. du Pont de Nemours 4 Company, Incorporated (19??) Benomyl:
Livestock Feeding Study—Milk and Meat. (Unpublished study
received Jul 1, 1970 under 1F1010; CDL:091750-N)
00035359 Klrkland, J.J.; Pease. H.L. (19??) Residue Data—Benomyl Livestock
Feeding Study. (Unpublished study received Jul 1, 1970 under
1F1010; submitted by E.I. du Pont de Nemours & Co., Inc.,
Wilmington, Del.; CDL:091750-0)
00035360 Klrkland, J.J. (1969) Determination of Residues of Benomyl and/or
Metabolites 1n Cow M1lk, Tissues, Urine and Feces. Undated
method. (Unpublished study received Jul 1, 1970 under 1F1010;
submitted by E.I. du Pont de Nemours & Co., Inc.; CDL: Wilming-
ton. Del.; CDL:091750-P)
00035361 Klrkland, J.J.; Reiser, R.U.; Wayne, W.J.; et al. (1969) Study of
Metabolites of Benomyl 1n Animal Feeding Tests. (Unpublished
study received Jul 1, 1970 under 1F1010; submitted by E.I. du
Pont de Nemours & Co., Inc., Wilmington, Del.; CDL:091750-Q)
163
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY .
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MR ID CITATION
00035615 E.I. du Pont de Nemours & Company, Incorporated (1971) Results of
Tests on the Amount of Residue Remaining on Treated Crops:
Benomyl. (Unpublished study received Aug 3, 1973 under
4F1427; CDL:093803-C)
00037182 E.I. du Pont de Nemours & Company, Incorporated (1969?) Results of
Tests on the Amount of Residue Remaining on Treated Crops: Be-
nomyl. (Unpublished study received Jan 23, 1970 under OG0936;
CDL:091599-A)
00037185 Baude, F.J. (1964?) Examination of C14-Res1dues on Glass and
Oranges Treated with Methyl l-(butylcarbamoyl)-2-Cl4-benzim1daz-
olecarbamate. (Unpublished study received Jan 23, 1970 under
OG0936; submitted by E.I. du Pont de Nemours & Co., Inc., Wil-
mington, Del.; CDL:091598-0)
00037186 Gardiner, J.A. (1964?) Metabolism of Methyl-l-(butylcarbamoyl)-2-
Cl4-benz1m1dazolecarbamate 1n Apple Leaves. (Unpublished study
received Jan 23, 1970 under OG0936; submitted by E.I. du Pont de
Nemours I Co., Inc., Wilmington. Del.; CDL:091599-E)
00037187 Baude, F.J. (1964?) Metabolism of Methyl l-(butylcarbamoylJ-2-C14-
benzlmldazole 1n Orange Leaves. (Unpublished study received Jan
23, 1970 under OG0936; submitted by E.I. du Pont de Nemours &
Co., Inc., Wilmington, Del.; CDL:091599-F)
00037188 Gardiner, J.A. (1964?) Metabolism of Methyl 1-(butylcarbamoyl)-2-
Cl4-benz1m1dazo1ecarbamate In Cucumber Seedlings. (Unpublished
study received Jan 23, 1970 under OG0936; submitted by E.I. du
Pont de Nemours & Co., Inc.; Wilmington, Del.; CDL:091599-G)
00037189 Gardiner, J.A. (1964?) Metabolism of Methyl l-(buty1carbamoyl)-2-
Cl4-benz1m1dazo1ecarbamate 1n Bean Seedlings. (Unpublished
study received Jan 23, 1970 under OG0936; submitted by E.I. du
Pont de Nemours & Co., Inc., Wilmington, Del.; CDL:091599-H)
00037196 Peterson, C.A.; Edglngton, L.V. (1969) Quantitative estimation of
the fungicide Benomyl using a bioautograph technique. Journal
of Agricultural and Food Chemistry 17(4):898-899. (Also 1n un-
published submission received Jan 23, 1970 under OG0936; submit-
ted by E.I. du Pont de Nemours ft Co., Inc., Wilmington, Del.;
CDL:091599-0)
00037360 Han, J.C. (19??) Residues on Plant Foliage Sprayed with Benomyl 1n
the Presence of Alkaline Pesticides. (Unpublished study re- i /•/
ceived Sep 16, 1971 under 1F1033; submitted by E.I. du Pont de ' °n
Nemours ft Co., Inc., Wilmington, Del.; CDL:091918-A)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
HRID CITATION
00037361 Baude, F.J. (1971) Residues on Oranges and Apples Treated with a
Wax Coating Containing Benlate(R) Benomyl Fungicide. (Unpub-
lished study received Sep 16, 1971 under 1F1033; submitted by
E.I. du Pont de Nemours & Co., Inc., Wilmington, Del.; CDL:
091918-B)
00037362 Morales, R. (19??) Residues 1n Freshly Limed Soil following Appli-
cation of Benlate(R) Benomyl Fungicide. (Unpublished study
received Sep 16, 1971 under 1F1033; submitted by E.I. du Pont de
Nemours & Co., Inc., Wilmington, Del.; CDL:091918-C)
00037363 Baude. F.J. (1971) Benlate(R) Benomyl Fungicide—Stability 1n
Aqueous Suspensions. (Unpublished study received Sep 16, 1971
under 1F1033; submitted by E.I. du Pont de Nemours & Co., Inc.,
Wilmington, Del.; CDL:091918-D)
00037364 E.I. du Pont de Nemours & Company, Incorporated (19??) Crop Residue
Data—STB. (Unpublished study received Sep 16, 1971 under
1F1033; CDL:091918-E)
00037365 Pease, H.L.; Gardiner, J.A. (1970) Results of Tests on the Amount
of Residue Remaining on Treated Crops: Benomyl. (Unpublished
study Including published data, received Sep 16, 1971 under
1F1033; submitted by E.I. du Pont de Nemours i Co., Inc., Wil-
mington, Del.; CDL:091918-F) .
00038451 Baude, F.J. (1964?) Stability of Benomyl on Apple, Banana, Cucum-
ber, Grape, and Orange Leaves under Outdoor Exposure Conditions.
(Unpublished study received Sep 16, 1971 under 1F1033; submitted
by E.I. du Pont de Nemours & Co., Inc., Wilmington, Del.; CDL:
091918-G)
00038808 Fitzpatrlck, K. (1980) Chinese Hamster Ovary Cell Assay for Muta-
genldty: Haskell Laboratory Report No. 438-80. (Unpublished
study Including letter dated Jun 16, 1980 from J.A. Gardiner to
Esther Salto, received Jun 17, 1980 under 352-354; submitted by
E.I. du Pont de Nemours & Co., Wilmington, Del.; CDL:242834-A)
00040272 E.I. du Pont de Nemours A Company, Incorporated (1971) Results of
Tests on the Amount of Residue Remaining on Treated Crops: Ben-
omyl. (Unpublished study received Sep 1, 1971 under 2G1197;
CDL:095931-B)
165
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MR ID CITATION
00044601 Han, J.C.Y. (1979?) Metabolism of 2-14C-Benomyl 1n the Goat (Sup-
plement II): Document No. AMR-24-80. (Unpublished study re-
ceived Aug 8, 1980 under 352-354; submitted by E.I. du Pont de
Nemours & Co., Wilmington, Del.; CDL:099534-A)
00044906 Interregional Research Project Number 4 (1969) Outline of Procedure
Used for Analysis of Red Beets for Benomyl Residue. Undated
method. (Unpublished study received Sep 4, 1980 under OE2409;
CDL:099579-B)
00046244 Springer, J.K.; Johnston, S.A.; Ercegovlch, C.D. (1980) Residue
.Studies—Eggplants, Peppers. (Unpublished study received May
15, 1980 under 352-354; prepared 1n cooperation with Rutgers,
the State Univ. of New Jersey, Research and Development Center,
Cooperative Extension Service and Pennsylvania State Univ.,
Pesticide Residue Laboratory, submitted by E.I. du Pont de Ne-
mours & Co., Wilmington, Del.; CDL:099432-A)
00046245 Pennsylvania State University, Pesticide Research Laboratory and
Graduate Study Center (1977) Outline of Procedure Used for Anal-
ysis of. Eggplant for Benomyl Residue. Undated method. (Unpub-
lished study received May 15, 1980 under 352-354; submitted by
E.I. du Pont de Nemours & Co., Wilmington, Del.; CDL:099432-B)
00046319 Pennsylvania State University, Pesticide Research Laboratory and
Graduate Study Center (1977) Outline of Procedure Used for Anal-
ysis of Pepper for Benomyl Residue. Undated Method. (Unpub-
lished study received May 15, 1980 under 352-354; submitted by
E.I. du Pont de Nemours & Co., Wilmington, Del.; CDL:099432-C)
00048098 Hunter, J.E.; Conway, K.E.; Splttler, T.D.; et al. (1980) Summary
of Residue Chemistry Data. (Unpublished study received Sep 4,
1980 under OE2409; prepared 1n cooperation with Cornell Univ.,
New York State Agricultural Experiment Station, Dept. of Plant
Pathology and others, submitted by Interregional Research Proj-
ect No. 4, New Brunswick, N.J.; CDL:099579-A)
00048099 Pease, H.L.; Gardiner, J.A. (1969) Fluorometric and colorlmetric
procedures for determining residues of Benomyl. Journal of Ag-
ricultural and Food Chemistry 17(2):267-270. (Also 1n unpub-
lished submission received Sep 4, 1980 under OE2409; submitted
by Interregional Research Project No. 4, New Brunswick, N.J.;
CDL:099579-C)
166
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MRID
CITATION
00052321 E.I. du Pont de Nemours 4 Company, Incorporated (1972) Residue
Data for Benomyl In Beans. (Unpublished study received on
unknown date under 4F1421; CDL:093793-A)
00052322 Holt, R.F. (1974) Benomyl Cooking Studies. (Unpublished study re-
ceived on unknown date under 4F1421; submitted by E.I. du Pont
de Nemours 4 Co., Inc., Wilmington, Del.; CDL:093793-B)
00052323 E.I. du Pont de Nemours 4 Company, Incorporated (197?) Results of
Questlonalre: Are Vines from Harvested Green Beans or Lima Beans
1n Your Area Fed to Dairy Cattle. (Unpublished study received
on unknown date under 4F1421; CDL:093793-C)
00052324 E.I. du Pont de Nemours 4 Company, Incorporated (1972) Results of
Tests on the Amount of_Res1due Remaining on Treated Crops:
Benomyl. (Unpublished study received on unknown date under
4F1421; CDL:093793-D)
00054213 E.I. du Pont de Nemours 4 Company, Incorporated (1972) Residue Da-
ta: Benpmyl, STB: Grapes, Grape Pomace and Raisin Waste. (Un-
published study received on unknown date under 2F1218; CDL:
091046-A)
00054214 E.I. du Pont de Nemours 4 Company, Incorporated (1973) Benomyl:
Feeding and Residue Studies with Laying Hens. (Unpublished
study received on unknown date under 2F1218; CDL:091046-B)
00054216 E.I. du Pont de Nemours 4 Company, Incorporated (1971) Results of
Tests on the Amount of Residue Remaining on Treated Crop: Beno-
myl. (Unpublished study received Jul 16, 1972 under 2F1218;
CDL:091046-D)
00061618 Lee, K.P. (1977) Methy1-l-(buty1carbamoy1)-2-benz1m1dazo1e car-
bamate (INT-1991): H-5167—MR-2529--B1©chemicals Department:
Two-Year Feeding Study—Beagle Dogs: Supplementary Pathology
Report No. 74-77. (Unpublished study received Feb 9, 1978 under
352-354; submitted by E.I. du Pont de Nemours 4 Co., Wilmington,
Del.; CDL:232864-A)
00063822 FHC Corporation (1973?) FMC Polyram—Benlate Apple Residue Samples.
(Unpublished study received Feb 6, 1975 under 279-2032; CDL:
227773-B)
00064820 Dashlell, O.L.; Ashley, P. (1980) Eye Irritation in Rabbits—EPA
Pesticide Registration: Haskell Laboratory Report No. 497-80.
(Unpublished study received Aug 8, 1980 under 352-396; submitted
by E.I. du Pont de Nemours 4 Co., Wilmington, Del.; CDL:
243043-B)
167
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MR ID CITATION
00064821 Dashiell, O.L.; Silber, L.S. (1980) Skin Irritation Test on Rabbits
for EPA Pesticide Registration: Haskell Laboratory Report
No. 367-80. (Unpublished study received Aug 8, 1980 under 352-
396; submitted by E.I. du Pont de Nemours A Co., Wilmington,
Del.; CDL:243043-C)
00064822 Dashiell, O.L.; Ashley. P. (1980) Acute Skin Absorption LD50 Test
on Rabbits (EPA Pesticide Registration Guidelines): Haskell Lab.
oratory Report No. 554-80. (Unpublished study received Aug 8,
1980 under 352-396; submitted by E.I. du Pont de Nemours & Co.,
Wilmington, Del.; CDL:243043-D)
00066771 Sherman, H.; Barnes, J.R.; Krauss, W.C.; et al. (1967) Ninety-day
Feeding Study with l-Butylcarbamoy1-2-benzini1dazolecarbam1c
Add, Methyl Ester INT-1991: Haskell Laboratory Report No. 11-
67. (Unpublished study received May 18. 1970 under OF0906;
submitted by E.I. du Pont de Nemours & Co., Inc., Wilmington,
Del.; CDL:091561-A)
00066773 Sherman, H. (1968) Three-generation Reproduction Study 1n Rats with
l-Butyfcarbamoyl-2-benz1m1dazolecarbamic Acid, Methyl Ester
INT-1991: Haskell Laboratory Report No. 264-68. (Unpublished
study received May 18, 1970 under OF0906; submitted by E.I. du
Pont de Nemours & Co., Inc., Wilmington, Del.; CDL:091561-C)
00066782 Knott, W.; Johnston, C.D. (1968) Fungicide 1991—Safety Evaluation
on Bluegill Sunfish. (Unpublished study received May 18, 1970
under OF0906; prepared by Woodard Research Corp., submitted by
E.I. du Pont de Nemours & Co., Inc., Wilmington, Del.; CDL:
091561-L)
00066783 Busey, W.M. (1968) Final Report: Acute Dietary Administration--
Mallard Ducklings and Bobwhite Quail: Project No. 201-215:
MR-581. (Unpublished study received May 18, 1970 under OF0906;
prepared by Hazleton Laboratories, Inc., submitted by E.I. du
Pont de Nemours & Co., Inc., Wilmington, Del.; CDL:091561-M)
00066784 E.I. du Pont de Nemours & Company, Incorporated (1968) Residue
Data: Benomyl—Bananas. (Compilation; unpublished study re-
ceived May 18, 1970 under OF0906; CDL:091561-N)
00066785 Sherman, H.; Fretz, S.B.; Henry, N.W., III; et al. (1968) Three-
month Feeding Study on Dogs with l-Butylcarbamoyl-2-benzimida-
zolecarbamic Acid, Methyl Ester INT-1991: Haskell Laboratory
Report No. 269-68. (Unpublished study received May 18, 1970
unde- OF0906; submitted by E.I. du Pont de Nemours 4 Co., Inc., «
Wilmington, Del.; CDL:091561-P) '
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MR ID CITATION
00067421 E.I. du Pont de Nemours & Company, Incorporated (1976) Benomyl
Technical Data Sheet. (Unpublished study received Feb 23, 1977
under 352-377; CDL:228142-F)
00070426 Helnemann, J.M. (1971) Final Report: Acute Static F1sh Toxldty
Study—Freshwater: Project No. 201-25.) (Unpublished study re-
ceived on unknown date under 352-EX-73; prepared by TRW, Inc.,
submitted by E.I. du Pont de Nemours & Co., Wilmington, Del.;
CDL:127068-D)
00077070 E.I. du Pont de Nemours & Company (1977) Benomyl Residue—Various
Crops. (Compilation; unpublished study received Jun 25, 1981
under 352-354; CDL:245488-A)
00077760 Johansen, C. (19??) Small-scale Bee Poisoning Tests with Honey
Bees, Alkali Bees, and-Alfalfa Leafcutting Bees. (Unpublished
study received Mar 16, 1970 under OF0961; submitted by Nor-Am
Agricultural Products. Inc., Napervllle, 111.; CDL:093272-C)
00078579 Sleight, B.H.. Ill (1972) Acute Toxldty of Benlate(R) to Grass
Shrimp (Palaemonetes vulgaris). (Unpublished study received
Jul 25, 1972 under 352-EX-73; prepared by Bionomics, Inc., sub-
mitted by E.I. du Pont de Nemours & Co., Wilmington, Del.; CDL:
128488-C)
00078626 E.I. du Pont de Nemours & Company, Incorporated (1975) Results of
Tests on the Amount of Residue Remaining on Treated Crops:
Benlate. (Unpublished study received on unknown date under
5H1748; CDL:238044-B)
00081913 Lee, K.P. (1970) Benz1m1dazolecarbam1c Acid, Methyl Ester, Int-
1991: Two-year Feeding Study—Dogs: Pathology Report No. 129-69.
(Unpublished study received Jul 10, 1971 under 1F1031; submitted
by E.I. du Pont de Nemours & Co., Inc., Wilmington, Del.; CDL:
091862-A)
00081915 E.I. du Pont de Nemours & Company, Incorporated (1970) Results of
Tests on the Amount of Residue Remaining on Treated Crops: Ben-
omyl. (Unpublished study received Jul 10, 1971 under 1F1045;
CDL:091862-C)
00084579 Dashlell, O.L.; Sllber, L.S. (1981) Eye Irritation In Rabbits:
Haskell Laboratory Report No. 179-81. (Unpublished study re-
ceived Aug 6, 1981 under 352-396; submitted by E.I. du Pont de
Nemours & Co., Wilmington, Del.; CDL:245910-A)
169
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MR ID
CITATION
00096514 Schneider, P.W., Jr.; Wlechman, B.E.; DHworth, T.; et al. (1980)
Long-term Feeding Study with Methyl l-(Butylcarbamoyl)-2-benz1-
nridazolecarbamate, (INT-1991, Benomyl, Benlate(R)) 1n Mice:
Haskell Laboratory Report No. 20-82. Final rept. (Unpublished
study received Mar 30, 1982 under 352-417; submitted by E.I. du
Pont de Nemours & Co., Inc., Wilmington, Del.; CDL:246948-A;
246949; 246950)
00097167 E.I. du Pont de Nemours & Company, Incorporated (1971) Data Sup-
porting the Use of Benlate(R) Benomyl Fungicide plus Man-
zate(R) 200 Fungicide (Tank Mix) for Control of Certain Dis-
eases of Peanuts. (Unpublished study received on unknown date
under 352-341; CDL:126318-A)
00097259 E.I. du Pont de Nemours & Company, Incorporated (1971) Benlate
Benomyl Fungicide Aerial Application: Sugar Beets—Peanuts.
(Unpublished study received Oct 7, 1971 under 352-354; CDL:
003082-A)
00097267 E.I. du Pont de Nemours I Company, Incorporated (1973?) Data Sup-
porting the Use of Benlate(R) Benomyl Fungicide on Almonds.
(Unpublished study received Mar 22, 1974 under 352-354; CDL:
026563-B)
00097269 E.I. du Pont de Nemours & Company, Incorporated (1973) Data Sup-
porting the Use of Benlate Benomyl Fungicide on Strawberries.
(Compilation; unpublished study received Jan 18, 1974 under
352-354; CDL:026701-A)
00097277 Sherman, H. (1969) Oral LD50 Tests: Haskell Laboratory Report
No. 17-69. (Unpublished study received Sep 14, 1969 under 352-
354; submitted by E.I. du Pont de Nemours & Co., Inc., Wilming-
ton, Del.; CDL:050427-E)
00097281 Hornberger, C.S. (1969) Acute Dust Inhalation—Rats: Benlate(R)
Fungicide: Haskell Laboratory Report No. 95-69. (Unpublished
study received Sep 14, 1969 under 352-354; submitted by E.I. du
Pont de Nemours & Co., Inc.. Wilmington, Del.; CDL:050427-L)
00097284 Sherman, H. (1969) Long-term Feeding Study 1n Rats with 1-Butyl-
carbamoyl-2-benz1m1dazolecarbam1c Add, Methyl Ester INT-1991;
Benalte(R); Benomyl: Haskell Laboratory Report No. 232-69.
(Unpublished study received Sep 14, 1969 under 352-354; sub-
mitted by E.I. du Pont de Nemours A Co., Inc., Wilmington, Del.;
CDL:050427-Q)
170
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
HRID CITATION
00097287 Hood, D.B. (1969) Fifteen-exposure Dermal Study with Benlate(R)
l-(N-Butylcarbamoyl)-2-benz1m1dazole Carbamlc Acid, Methyl Ester
(INT-1991): Maskell Laboratory Report No. 211-69. (Unpublished
study received Sep 14, 1969 under 352-354; submitted by E.I. du
Pont de Nemours 4 Co., Inc.. Wilmington, Del.; CDL:050427-U)
00097289 Col burn, C.W. (1969) Primary Skin Irritation and Sensltlzatlon
Test: Haskell Laboratory Report No. 84-69. (Unpublished study
received Sep 14, 1969 under 352-354; submitted by E.I. du Pont
de Nemours & Co., Inc., Wilmington, Del.; CDL:050427-W)
00097293 E.I. du Pont de Nemours and Company, Incorporated (1971) Results
of Tests on the Amount of Residue Remaining on Treated Crops:
Benomyl. (Unpublished study received Apr 17, 1971 under
1G1145; CDL:090932-A)
00097294 Leltch, R.E.; Macturk, R.B.J197?) Analysis of Benomyl and/or
Metabolites 1n Cow Milk and Tissues by Liquid Chromatography—
Adaptation of the Method to a Commercial Liquid Chromatograph.
(Unpublished study, Including letter dated Jul 15, 1971 from
J.J. Klrkland to File, received May 11, 1972 under 2F1192;
submitted by E.I. du Pont de Nemours A Co., Inc., Wilmington,
Del.; CDL:091004-A)
00097299 E.I. du Pont de Nemours & Company, Incorporated (1971) Residue
Data: Benomyl—Strawberries (Caps Removed). (Unpublished study
received Nov 5, 1971 under 2F1212; COL:091038-A)
00097301 E.I. du Pont de Nemours and Company, Incorporated (1972) Results of
Tests on the Amount of Residue Remaining on Treated Bananas:
Benomyl. (Unpublished study, Including published data, re-
ceived Aug 12. 1972 under 2F1234; CDL:091091-A)
00097303 E.I. du Pont de Nemours A Company, Incorporated (1969) Benomyl
Residue Data—Stone Fruits. (Compilation; unpublished study
received Feb 6, 1970 under OF1000; CDL:091728-A)
00097305 Sherman, H.; Miller, A.L.; Miles. E.N.; et al. (1970) Long-term
Feeding Study In Dogs with !-Buty1carbamoyl-2-benz1m1dazole-
carbamlc Acid, Methyl Ester INT-1991; Benlate(R); Benomyl:
Haskell Laboratory Report No. 48-70. (Unpublished study re-
ceived on unknown date under OF1000; submitted by E.I. du Pont
de Nemours & Co., Inc., Wilmington, Del.; CDL:091728-D)
171
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MR ID
CITATION
00097306 E.I. du Pont de Nemours & Company, Incorporated (1971) Results of
Tests on the Amount of Residue Remaining on Treated Crops:
Benomyl. (Compilation; unpublished study, Including published
data, received Aug 15, 1972 under 2F1240; CDL:091761-A)
00097308 Interregional Research Project Number 4 (1972) Analyses for Deter-
mining Residues of Benomyl—Mushrooms. (Compilation; unpub-
lished study, Including published data, received Aug 15, 1972
under 2E1239; CDL:091763-A)
00097310. E.I. du Pont de Nemours 4 Company, Incorporated (1968) Benomyl
•Residue Data—Grapes. (Compilation; unpublished study received
Jul 1, 1971 under 1G1038; CDL:091852-B)
00097311 E.I. du Pont de Nemours & Company, Incorporated (1971) Residue
Studies of Benomyl on-Mangoes. (Compilation; unpublished
study, Including published data, received Feb 5, 1973 under
2F1289; CDL:092184-A)
00097313 E.I. du Pont de Nemours & Company, Incorporated (1971) Residue
Studies* of Benomyl on Avocados. (Compilation; unpublished
study, Including published data, received Feb 5, 1973 under
2F1290; CDL:092185-A)
00097315 E.I. du Pont de Nemours & Company, Incorporated (1971) Results of
Tests on the Amount of Residue Remaining on Treated Crops:
Benomyl. (Unpublished study received Feb 5, 1973 under
2F1291; CDL:092186-A)
00097316 E.I. du Pont de Nemours & Company, Incorporated (197?) Residue
Data: Benomyl—Stone Fruits. (Unpublished study received Dec
3, 1970 under OF1000; CDL:093310-A)
00097318 Lee, K.P. (1971) Methyl l-(butylcarbamoyl)-2-benz1m1dazo1ecarbamate
(INT-1991): H-5167—MR-966— I & B Dept.: Supplementary Pathology
Report No. 53-71. (Unpublished study, Including letter dated
Aug 2, 1971 from T.W. Hanavan to Drew M. Baker, Jr., received
Aug 4, 1971 under OF0906; submitted by E.I. du Pont de Nemours
& Co.. Inc., Wilmington, Del.; CDL:093205-A)
00097321 S1ms, J.J.; Mee, H.; Erwln. D.C. (1969) Methyl 2-benz1m1dazolecar-
bamate, a fungi toxic compound Isolated from cotton plants
treated with ... (benomyl). Phytopathology 59(Nov):1775-1776.
(Also In unpublished submission received Dec 29, 1969 under
OF0936; submitted by E.I. du Pont de Nemours & Co., Inc., Wil-
mington, Del.; .CDL:093241-B)
172
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MR ID CITATION
00097326 Lee, K.P. (1971) Methyl l-(Butylcarbamoy1)-2-benz1m1dazolecarbamate
(INT-1991): H-5167—MR-1418--I & B Dept.: Supplementary Patholo-
gy Report No. 54-71. (Unpublished study, Including letter dated
Aug 2, 1971 from T.W. Hanavan to Drew M. Baker, Jr.. received
Oct 31, 1969 under OF0906; submitted by E.I. du Pont de Nemours
ft Co., Inc., Wilmington, Del.; CDL;093205-F)
00097331 E.I. du Pont de Nemours & Company, Incorporated (1971) Residues
of Benomyl In Peanuts, Beans and Other Crops. (Compilation;
unpublished study received Jun 15, 1971 under 1F1010; CDL:
093320-H)
00097335 E.I. du Pont de Nemours ft Company, Incorporated (1971) Residue Da-
ta— Benomyl: Postharvest Treatment of Apples: Apple Pomace.
(Unpublished study received on unknown date under 1F1033; CDL:
093342-B) __
00097337 Rosen, D.E. (1971) Letter sent to Charles L. Smith dated Mar 17,
1971: Benomyl—pesticide petition 1F1045. (Unpublished study
received Mar 19, 1971 under 1F1045; submitted by E.I. du Pont de
Nemours & Co., Inc., Wilmington, Del.; CDL:093357-A)
f
00097338 Pease, H.L.; Gardner, J.A. (1969?) Detailed Procedure for Isolation
and Determination of Benomyl Residues. Undated method. (Unpub-
lished study received Sep 22, 1970 under 1F1045; submitted by
E.I. du Pont de Nemours ft Co., Inc., Wilmington, Del.; CDL:
093357-B)
00097340 Baude, F.J. (1971) The Stability of Benlate(R) Benomyl Fungicide
at Neutral and Alkaline pH Levels. (Unpublished study received
Mar 1, 1971 under 1F1145; submitted by E.I. du Pont de Nemours
ft Co., Inc., Wilmington, Del.; CDL:093462-A)
00097342 E.I. du Pont de Nemours ft Company, Incorporated (1970) Peanut For-
age, Hay, Hulls, Sugar Beet Tops. Includes undated method en-
titled: Improved method for determining benomyl residues. (Un-
published study received Aug 17, 1971 under 2F1192; CDL:
093517-B)
00097343 E.I. du Pont de Nemours ft Company, Incorporated (1971) M1lk—Meat:
Residues of Benomyl. Includes undated method entitled: Method
for confirmatory Identification of benomyl and/or 5-hydroxy
metabolite by solvent partitioning. (Unpublished study received
Aug 17, 1971 under 2F1192; CDL:093517-C)
173
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
HRID CITATION
00097344 E.I. du Pont de Nemours & Company, Incorporated (1973) Results of
Tests on the Amount of Residue Remaining on Treated Crops: Ben-
omyl. Includes method dated Mar 7, 1973. (Unpublished study
received Jun 20, 1973 under 3F1410; CDL:093769-A)
00097347 E.I. du Pont de Nemours & Company, Incorporated (1974) Residue
Study of Benomyl on Tomatoes. (Compilation; unpublished study,
Including published data, received Dec 28, 1973 under 4F1452;
CDL:093870-B)
00097349 E.I. du Pont de Nemours & Company, Incorporated (1973) Results of
Tests on the Amount of Residues Remaining on Treated Crops:
Benomyl. (Compilation; unpublished study, Including pub-
lished data, received Feb 1, 1974 under 4F1466; CDL:093905-A)
00097354 E.I. du Pont de Nemours 4-Company, Incorporated (1973) Residue
Data: Benomyl— Poultry Liver. (Unpublished study received Dec
9. 1971 under 2F1218; CDL:094075-D)
00097355 Rhodes, R.C. (1971) Uptake of 2-14C-Benomyl Soil Residues by
Crops. ' (Unpublished study received Mar 9, 1971 under 1F1010;
submitted by E.I. du Pont de Nemours & Co., Inc., Wilmington,
Del.; CDL.-094542-B)
00097578 E.I. du Pont de Nemours ft Company, Incorporated (1975?) Results of
Tests on the Amount of Residue Remaining on Treated Crops:
Benlate. (Compilation; unpublished study, Including published
data, received Feb 25, 1976 under 352-354; CDL:097373-C)
00097580 Interregional Research Project Number 4 (1976) Summary of Residue
Data for Benomyl 1n Sweet Potatoes. (Compilation; unpublished
study received Oct 17, 1978 under 9E2136; CDL:097453-A)
00097584 Han, J.C.Y. (1976?) Metabolism of 2- 14C -Benomyl 1n the Lactatlng
Nanny Goat. (Unpublished study received Feb 6, 1979 under
352-354; submitted by E.I. du Pont de Nemours & Co., Inc.,
Wilmington, Del.; CDL:097791-A)
00097590 E.I. du Pont de Nemours & Company, Incorporated (1975) Results
of Tests on the Amount of Residue Remaining on Treated Crops:
Benomyl. (Compilation; unpublished study, Including published
data received Nov 25, 1975 under 6F1707; CDL:098098-B)
174
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MR ID CITATION
00097592 Interregional Research Project Number 4 (1978) Summary of Residue "
Data for Benomyl 1n Turnips and Turnip Greens. (Compilation;
unpublished study received Aug 30, 1979 under 9E2259;.CDL:
098945-A)
00097594 Han. J.C.Y. (1977) Metabolism of 2-14C-Benomyl 1n the Lactatlng
Nanny Goat (Supplement). (Unpublished study received Nov 20,
1979 under 352-354; submitted by E.I. du Pont de Nemours & Co.,
Inc., Wilmington, Del.; CDL:099097-A)
00097599 Busey. W.M. (1968) Final Report: Acute Inhalation Exposure—Rats:
LCt50" Determination: Project No. 201-220; MRO 1126. (Unpub-
lished study received Oct 18, 1968 under unknown admin, no.;
prepared by Hazleton Laboratories, Inc., submitted by E.I. du
Pont de Nemours ft Co., Inc., Wilmington, Del.; CDL:105917-A)
00097605 Gardiner, J.A. (197?) Examination of Cl4-Res1due on Glass and
Apples Treated with Methyl l-(Butylcarbamoyl)-2-Cl4-benz1m1-
dazolecarbamate. (Unpublished study received 1969 under 352-
EX-71; submitted by E.I. du Pont de Nemours & Co., Inc., Wil-
mington. Del.; CDL:123354-0)
00097611 Peterson, C.A.; Edglngton, L.V. (1969) Translocatlon of the fun-
gicide benomyl 1n bean plants. Phytopathology 59(Aug):1044.
Taken from: Without title?. (Also 1n unpublished submission
received 1969 under 352-EX-71; submitted by E.I. du Pont de
Nemours & Co., Inc., Wilmington, Del.; CDL:123354-Q)
00097613 Baude, E.J. (1972) Letter sent to D.E. Rosen dated Feb 28, 1972:
Absence of STB on benomyl-treated bean plants. (Unpublished
study received Aug 7. 1972 under 352-EX-77; submitted by E.I.
du Pont de Nemours ft Co., Inc., Wilmington, Del.; CDL:123360-B)
00097615 Pitcher, F. (1972) DuPont Benlate Benomyl Fungicide Wettable
Powder: Rainbow Trout (Salmo galrdneM): Test No. 495.
(U.S. Agricultural Research Service, Pesticides Regulation
D1v., Animal Biology Laboratory; unpublished study; CDL:
129818-A)
00097621 E.I. du Pont de Nemours ft Company, Incorporated (1976) Data Sup-
porting Use of Benlate Benomyl Fungicide on Tomatoes by Aerial
Application. (Unpublished study received Oct 29, 1976 under
352-354; CDL:228179-A)
00097626 E.I. du Pont de Nemours & Company, Incorporated (1976) Benlate(R)
Compatibility with Fixed Coppers. (Unpublished study received
Jun 13, 1978 under 352-354; CDL:235190-D)
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MR ID CITATION
00097628 Belasco, I.J. (19??) 2-14C-Benomyl (50 WP) Compatibility with
Fixed Coppers. (Unpublished study received Mar 30, 1979 under
352-354; submitted by E.I. du Pont de Nemours ft Co., Inc., Wilm-
ington, Del.; CDL.-238021-A)
00098695 FMC Corporation (1975) Polyram 80 UP: Residue Data: Reply to EPA
Letter of July 1974. (Compilation; unpublished study, Includ-
ing M-3589, received Feb 6, 1975 under 279-2032; CDL:101267-A)
00100751 Hardesty, P. (1982) Attempts To Characterize Liver Residues from
14C-Benomyl Dosed Goat: Document No. AMR-71-82. (Unpublished
study received May 4, 1982 under 352-354; submitted by E.I. du
Pont de Nemours ft Co., Inc., Wilmington, DE; CDL:070833-A)
00104728 Klrkland, J.J.; Pease, H.L. (19??) Residue Data: Benomyl Livestock
Feeding Study. (Unpublished study received May 11, 1972 under
2F1192; submitted by ETl. du Pont de Nemours ft Co., Inc.,
Wilmington. Del.; CDL.-091004-B)
00106030 Markle, G. (1978) Letter sent to C. Fletcher dated Jan 27, 1978:
Benomyl/brasslca (s.t.) (PR 1385). (Unpublished study received
Jul 8, '1982 under OR 82/46; prepared by Interregional Research
Project No. 4, submitted by E.I. du Pont de Nemours ft Co., Inc.,
Wilmington, DE; CDL:247828-B)
00106600 Interregional Research Project Number 4 (1972) Residues of Benlate
1n Blueberries. (Compilation; unpublished study, Including
published data, received Mar 7, 1974 under 4E1479; CDL:097568-A)
00108623 E.I. du Pont de Nemours ft Co., Inc. (1975) Data Supporting the New
Benlate Benomyl Fungicide on Pecans. (Compilation; unpublished
study received Jun 2, 1975 under 352-354; CDL.-224995-A)
00115674 Staples. R. (1982) Benomyl Savage: Teratogenlclty Study in the
Rat: Haskell Laboratory Report No. 587-82. (Unpublished study
received Oct 19. 1982 under 352-354; submitted by E.I. du Pont
de Nemours ft Co.. Inc., Wilmington. DE; CDL:248563-A)
00126522 E.I. du Pont de Nemours ft Co., Inc. (1982) Supplement to the Ben-
omyl Gavage Teratogenlclty Study 1n the Rat: HLR 587-82. (Un-
published study received Feb 28, 1983 under 352-354; COL:
249749-A)
176
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benomyl Standard
MRID CITATION
00129168 Interregional Research Project No. 4 (1982) The Results of Tests
on the Amount of Benomyl Residues Remaining In or on Chinese
Cabbage, Including a Description of the Analytical Method Used.
(Compilation; unpublished study received Jul 5, 1983 under
3E2923; CDL:071745-A)
00151521 E.I. du Pont de Nemours ft Co., Inc. (1985?) Physical and Chemical
Properties of Technical Benomyl. Unpublished study. 2 p.
.00151522 E.I. du Pont de Nemours ft Co., Inc. (1985) [Process Description,
Statement of Composition, and Dlcussion of the Formation of
Impurities in Benomyl Techn1cal[. Unpublished compilation.
17 p.
00151523 E.I. du Pont de Nemours ft Co.. Inc. (1985) [Analysis of Product
Ingredients and Analytical Methods to Determine Impurities].
Unpublished compilation. 104 p.
05001991 Stevenson, J.H. (1978) The acute toxlcity of unformulated
pesticides to worker honey bees (Apis mellifera). Plant
Pathology 27(1):38-40.
177
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard For Benomyl/MBC
MR ID Citation
GS0119-001 Horst, A.; Krahn, D. (1980) Mutagenlcity Evaluation 1n Salmo-
nella/Typhimurlum: Haskell Laboratory Report No. 560-
80: Revised copy. Prepared by Haskell Laboratory for
Toxicology and Industrial Medicine. 9 p.
GS0119-002 Jotz, M.; Rundle, D.; Mitchell, A. (1980) An Evaluation of
Mutagenic Potential of Benomyl Employing the L5178Y TK+/-
Mouse Lymphoma Assay: Final Report: SRI Project No. LSU-
7558. Prepared by SRI International under contract no. 68-02-
2947 to US EPA. 9 p.
GS0119-003 K1rkhart( B. (1980) Mlcronucleus Test on Benomyl: SRI Project
No. LSU 7558-19. Prepared by SRI International as Work
Assignment #5 under contract no. 68-02-2947 to US EPA. 10 p.
GS0119-004 Evans, E.; Mitchell, A. (1980) An Evaluation of the Effect of
Benomyl on Sister Chromatld Exchange Frequencies 1n Cultured
Chinese Hamster Ovary Cells: Final Report: SRI Project No.
LSU-7558. Prepared by SRI International under contract no.
68-02-2947 to US EPA. 22 p.
GS0119-005 long, C. (1981) The Hefiatocyte Primary Culture/DNA Repair Assay
on Compound 10,962-02 using Mouse Hepatocytes In Culture.
Report No. HLO 741-81: NDI Experimental Nos. 081381 CT,
090281 CT. Unpublished report prepared by Naylor Dana
Institute, Valhalla NY. 17 p.
GS0119-006 Tong, C. (1981) The Hepatocyte Primary Culture/DNA Repair Assay
on Compound 10,962-02 using Rat Hepatocytes 1n Culture.
Report No. HLO 742-81: NDI Experimental Nos. 081081 CT,
090181 CT. Unpublished report prepared by Nay lor Data
Institute, Valhalla NY. 17 p.
GS0119-007 Deabm W.; Jessup, D. (1979) Acute Delayed Neurotoxlclty Study
in Chickens [Benomyl]: IRDC Study No. 125-039. Unpublished
report Including amendments dated Dec. 7, 1979, prepared by
International Research and Development Corp., Mattawan MI.
GS0119-008 Seller, J. (1976) The mutagenlcity of benzimidazole and
benzimidazole derivatives. VI. cytogenetic effects of
benzimidazole derivatives in the bone marrow of the mouse
and the Chinese hamster. Mutation Research: 40(1976) 339-348.
178
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard For Benomyl/MBC
MRID Citation
GS0119-009 Staples, R. (1980) Benomyl: Teratogenldty in the Rat after
Administration by Gavage: Medical Research Project No. 649-
80. Unpublished report prepared by Haskell Laboratory
for Toxicology and Industrial Medicine; Including-
supplemental data on Individual animals provided 1n 1985.
58 p. plus attachments.
GS0119-011 Schutz; Donaubauer (1982) (1984) Repeat-Dose (24-months) Feed-
Ing Study for Determination of the Cancerogenlc Effect of
HOE 17441 0 F AT204 (Carbendazlm) 1n Mice: Report No. 643-82:
of Document No. A24407. Translation from German of unpublished
study prepared by Hoechst Akiengesellschaft, Parma Research
Toxicology.
GS0119-012 Beans, R.; T11, H.; Vander Heijden C. (1976) Cardnogenlcity.
Study with Carbendazim (99% MBC) 1n Mice. Summary Report
No. R4936. Unpublished report by the Central Institute for
Nutrition and Food Research.
GS0119-013 Kappas, A.; Georgopoulos, 6.; Hastie, A. (1974) On the genetic
activity of benzlmldazole and thiophanate fungicides on
d1p161d Aspergillus nldulans. Mutation Research 26(1) 17-27.
GS0119-014 Belasco, I. (197?) 2-14t-Benomyl (50% UP) Adsorption Through Rat
Skin Part II: Effect of Time and Dose Applied. Unpublished
study Including "Skin Absorption Study 1n Rats..." Haskell
Laboratory Report No. 117-79, prepred by Blochemlcals Dept,
Research D1v, E.I. du Pont Nemours & Co., Inc., Wilmington,
DE. 17 p.
GS0119-015 Shternberg, A.; Torchlnsky, A. (1972) On the Interrelationship
of General Toxic, Embryotic and Teratogenic Action of Chemicals
Extraneous for the Organism and the Possibilities for
Prognostication their Influence on the Antenatal Period of
Ontogenesis. [Translation] Vestmik Akademil Nauk SSR:
3(27):39-46.
GS0119-016 Short, R.; Minor, J.; Unger, T.; et al. (1979) Teratology
of Benomyl. Unpublished study prepared by Midwest Research
Institute under contract no. 68-02-2982 to US EPA. 20 p.
GS0119-17 Kavlock, R.; Chernoff. N.; Gray, L.; et al. (1982) Teratogenic
effects of benomyl in the Wistar rat and CD-I mouse, with
emphasis on the route of administration. Toxicology and
Applied Pharmacology 62. 44-54.
179
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OS Nos
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Benorayl Standard
CITATION
GS0119-018 Smale, B.C. (1985) Memorandum sent to David L. Bowen dated
Decanber 20, 1985. Assessemnt of the Comparative Efficacy
and Pest Resistance of Benonyl.
GS0119-019 Johnson, W.W., Plnley M.T. (1980). Handbook of Acute Toxlclty
of Chemicals to Fish and Aquatic Invertebrates. Columbia
National Fisheries Research Laboratory. USDI/FWS Publication
137.
OS0119-020 Flnley M.T. (1977). Toxlclty Data for Benlate. Columbia
National Fisheries Research Laboratory. USDI/FWS.
GS0119-021 U.S. EPA (1976) Report on the Toxlclty of Twin Light Benonyl
Fungicides (50% Dust) to Rainbow Trout. (Unpublished Report,
Static Jar Test No. 100^ August 18, 1976. U.S. EPA, Chemical
and Biological Investigation Branch, Beltsville, Maryland.)
GS0119-022 U.S. EPA (1976) Report on the Toxlclty of Twin Light Benonyl
Fungicides (50% Dust) to Bluebgill sunfish. (Unpublished Report,
Static Jar Test No. 1019, Sept. 16, 1976. U.S. EPA, Chemical
and Biological Investigation Branch, Beltsville, Maryland.)
GS0119-023 U.S. EPA (1971) Report on the Toxlclty of DuPont Benlate Benorayl
Fungicide Wettable Powder to Rainbow trout. (Unpublished Report,
Static Jar Test No. 3^7, April 18, 1971. U.S. EPA, Chemical
and Biological Investigation Branch, Beltsville, Maryland.)
GS0119-02U U.S. EPA (1977) Report on the Toxlclty of DuPont Benlate 5W WP
and Benomyl (98.6X) to Blue gill sunfish, A letter containing
results and laboratory sheets. (Unpublished Report, Static Jar
Test Nos. 110H, 1108, 1109, 1110, June 22, 1977 and August 11,
1977. U.S. EPA, Chemical and Biological Investigation Branch,
Beltsville, Maryland.)
GS0119-025 U.S. EPA (1977) Report on the Toxiclty of Benlate 5W WP to
to Channel Catfish. (Unpublished Report, Static Jar Test No.
1120, October 3, 1977. U.S. EPA, Chemical and Biological Inves-
tigation Branch, Beltsville, Maryland.)
180
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GS Nos
OFFICE OP PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
•• Registrations Under the Benomyl Standard
CITATION
GS0119-026 U.S. EPA (1979) Report on the Toxicity of Technical Benorayl
(98%) to Daphnia magna. (Unpublished Report, Static Jar Test
No. 2428, November 21, 1979. U.S. EPA, Chemical and Biological
Investigation Branch, Beltsville, Maryland.)
GS0119-027 U.S. EPA (1979) Benonyl Position Document 2/3- August 22, 1979.
Special Pesticide Review Division, Office of Pesticide
Programs.
GS0119-028 U.S. EPA (1982) Bencrayl/Thiophanate-Methyl Position Document 4.
October 1, 1982. Special Pesticide Review Division, Office of
Pesticide Programs.
GS0119-029 California Dept. of Food and Agriculture (1976) Requesting A
Tolerance for Benomyl on Garlic. (Unpublished study, received
Decanber 30, 1976. under-PP#7E1929. Agricultural Chemicals
and Feed Division. Sacramento, CA).
GS0119-030 IR-4 Project. (1976) Section D. Petition Proposing Tolerances
. for Sweet Corn Production as a Seed Treatment. (Unpublished
study, received March 3, 1976. under PP#6E1760. Rutgers Univ.
New Brunswick, NJ.)
181
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EPA Form 8580-1
EPA Form 8580-6
EPA Form 8580-
V- FORMS APPENDICES
FIFRA S3(c)(2)(B) Summary Sheet
Certification of Attempt to Enter Into
an Agreement with Other Registrants for
Development of Data
t
Product Specific Data Report
(End-Use Products)
EPA Form 8580- Formulator's Exemption Statement
-------
OMB AoororitNo. 30O&Q46S
FIFHA SECTION 3(C)(2)(B) SUMMARY SHEET
EPA REGISTRATION NO.
PRODUCT NAME - ". ' .
APPLICANT'S NAME
I DATE GUIDANCE DOCUMENT ISSUE
With rno«ct to KM rrquremeni to «j8mii *fcn«ric" Jeti imooKd ov the FIFRA action 3(C)(2)(BI netiet :onn«i«a IT mi r
Gwdtnce Document. I am rtoonduif m tf>e following manner /
O I. I wWI ubmit dan in * um«iy m*nntr to mat» tnt 'ollomn; requifvncnii. If tn« ten O'octoura I will u« afvuif !rom ior or not
tpRiltcd in) me Registration Guidttmtt or tnt Profoco'i caninncd in me Repent e< Eiotn Crauet to trx C.ttm<«it Grouc OECO
T0t«4 Prognmnii. I cndo« me oratocais if.«t I will UK:
D 2. I twv« tnnrtt into *n tqrtrmini witti on* or mix* otncr rt^nlnnti undtr FlFRA MCtion 3(C)(2)(6)(ii) 10 utid* toe (oiiowing atti
nquirwntntt. Th« MM. ifld W»Y required protocoii. will bt mjtwnnttd to EPA by:
NAME OF OTHER REGISTRANT
2. I «oclo» « comolfttd 'Ctrtifici*on of Ancmpt to Enter Into in Agreement with Other Regittrints tor Oevelopment of Cid" »>i^
ruoeci to me following din rtquirtmtnn;
LJ 4. I nquen rnit you emend my rtgntration ey dcletmf (tie fallowing um (mn option • not evaiUolt to eooiicjntt lor new productu
Oil raquen yoiunterf ttncriUtion of UM rtgiftntwfl ol tfca prodwct. (Tta opnoa • not xiilitle t» «op4ie*ati lot new. eroductt.)
HECirnuNrs AUTHORIZED NEPRESCNTATIVC
SIGNATURE
DATE
183
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OMB Aoorovd No
CERTIFICATION OF ATTEMPT TO ENTER
INTO AN AGREEMENT WITH OTHER REGISTRANTS
(To ouiUfY. »r/(V4U *>« «"»« FOR OevELOPMBNT OF DATA
^ • -"•
1. 1 am duly authorized to reor«*tnt me following firm(»| who are aubjeet to the require
m*nu of • Notice under FlFRA Section 3(c)(2)(8l contained in a Guidance Document
to submit data concerning tnc active ingredient:
NAMC Or ««M
"
*f
OU 0 0 DC
EPA COMPANY NUMflEH '
(Thi» firm Of grouO Of firms i( referred to OetOw 4t "my firm'M |
2. My firm n willing (o develop and tuomit the Hit* as reouired by tnjt NoKe. i< neoetury However, my firm would prefer to entel
into *n «ore«ment with one or more otter registrants to develop jointly, or to tfta'e m trte cott of developing, the following reauiredj
items or data:
3. My firm hat offered in writing 10 enter into wen in agreement. Cooiei of tn» offert are inacnee T">jt offer wit irrevocable md included an offer te 3t
Bound by an arbitration decmon under FlFBA Section 3(c)(2)(8)(iii) if final aoreement on all terms could not be reacted otnerwtH This offer was mint
to tnt following firmUl on the following dtteisJ:
NAME Of tI«M
DATE Qf
However, none of they firm(sl accepted my offer.
4. My firm request* that EPA not fuspend the rcgicuation(s| of my firm'* product(s). if any of the firms named in paragraph (3) above
have •greed to tubmn the data lined in paragraph (2) above in accordance with the Notice. I undentand EPA will promptly inform
me whether my firm mutt jutamrt data to avoid *jspen*ion of its reghnrationCil under FlFRA Section 3(c)(2)(B). (Thn statement
docs not apply to applicanu for new product*.) I give EPA permission to tfitdotc this statement upon request.
TVFCO NAMC
•MNATUME
OATC
184
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EPA Registration No.
PRODUCT SPECIFIC DATA REPORT
Guidance Docunent for_
- , - Date
Registration
Guideline No.
§158.20
PRODUCT
CHEMISTRY
61-1
61-2
61-3
62-1
62-2
62-3
63-2
63-3
63-<»
63-5
63-6
63-7
63-3
63-9
63-10
63-11
63-12
Name of Test
Identity of
Ingredients
Statement of
composition
Discussion of
formation of
Ingredients
Preliminary —
analysis
Certification of
limits
Analytical methods
for enforcement
limits
Color
Physical state
Odor
Melting-point
Boiling point
Density, bulk-
density, or
specific gravity
Solubility
Vapor pressure
Dissociation
constant
Octanol/water
partition
coefficient
PH
Test not
required
for my
product
listed
above
(check
below)
.
I am complying with
data requirements by
Citing MRID#
Submit-
ting
Data
(At-
tached)
(Jbr EPA Use Only)
Accession Nunbers
Assigned
•
185
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Registration
Guideline No.
63-13
63-14
63-15
63-16
63-17
63-18
63-19
63-20
63-21
$158.135
TOXICOLOGY
81-1
81-2
81-3
81-4
81-5
81-6
Name of Test
Stability
Oxidizing/ reducing
reaction
Flanmabillty
Explodablllty
Storage stability
Viscosity
Mlsclblllty
Corrosion
characteristics
Dielectric break-—
down voltage
Acute oral LD-50,
rat
Acute dermal
LD-50
Acute Inhalation,
LC-50 rat
Primary eye
irritation, rabbit
Primary dermal
irritation
Dermal sensltlza-
tion
Test not
required
for my
product
listed
above
(check
below)
I am complying with
data requirements by
Citing MRID#
Submit-
ting
Data
(At-
tached)
(For EPA Use Only)
Accession Numbers
Assigned
'
186
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.PORftULATOR'S "EXEMPTION STATEMENT
(40 CFR 152.fl5) -
EPA File Symbol/Reg. No. Product Name
Applicant's Name and Address
As an authorized representative of the applicant for registration of the
product identified above, I hereby certify that:
(1) This product contains the active ingredient(s):
(2) Each active ingredient listed in paragraph (1) is present solely
as the result of the incorporation _into the product (during formulation or
packaging) of another product which contains that active ingredient, which
is registered under FIFRA sec. 3, and which is purchased bv us from another
producer.
(3) Indicate by circling (A) or (B) below which paragraph applies:
*
(A) An accurate Confidential Statement of Formula (EPA Form 8570-4) for
the above identified product is attached to this statement. That formula
statement indicates, by company name, registration number and product
name, the source of the active ingredient(s) listed in paragraph (1).
OR
(B) The Confidential Statement of Formula dated on file with
the EPA is complete, current and accurate and contains the information
required on the current CSF Form No. 8570-4. The registered source(s)
of the active ingredient(s) listed in paragraph (I) is/are listed
Active ingredient Source; Product name and Reg. No.
Signature
nate : Title
EPA Form (April 1985)
187
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. FORMULJVTOR' S " EXEMPTION STATEMENT
(40 CF* 152.85) -
EPA File Symbol/Reg.-No. Product Name
Applicant's Name and Address
As an authorized representative of the applicant for registration of the
product identified above, I hereby certify that:
(1) This product contains the active ingredient(s):
(2) Each active ingredient listed in paragraph (1) is present solely
as the result of the incorporation into the product (during formulation or
packaging) of another product which contains that active ingredient, which
is registered under FIFRA sec. 3, and which is purchased bv us from another
producer.
(3) Indicate by circling (A) or (8) below which paragraph applies:
*
(A) An accurate Confidential Statement of Formula (EPA Form 8570-4) for
the above identified product is attached to this statement. That formula
statement indicates, by company name, registration number and product
name, the source of the active ingredient(s) listed in paragraph (1).
OR
(B) The Confidential Statement of Formula dated on file with
the EPA is complete, current and accurate and contains the information
required on the current CSF Form No. B570-4. The registered source(s)
of the active ingredient(s) listed in paragraph (1) is/are listed below:
Active ingredient Source: Product name and Reg. No.
Signature
nate Title
EPA Form (April 1985)
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