MASTER TESTING LIST - 1992
December 1, 1992
OFFICE OF POLLUTION PREVENTION AND TOXICS
OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES .'
U.S. ENVIRONMENTAL PROTECTION AGENCY
L__WASHING.T.ON D...C-—2,04.60,.
Master Testing List [CCD]
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MASTER TESTING LIST - 1992
Table of Contents
PAGE
INTRODUCTION 1
< • • '
ADDITIONS TO THE MTL 2
DELETIONS FROM THE MTL 5
FORMAT CHANGES TO THE MTL 7
PARTICIPATING IN THE CHEMICAL TESTING PROGRAM 11
APPENDIX I (EXISTING CHEMICALS PROGRAM - AN OVERVIEW) 12
f •
i
"APPENDIX n (PUBLIC COMMENTS/ISSUES) 19
MASTER TESTING LIST 21
INDEX OF CHEMICALS 21
INDEX OF SOURCES 30
CATEGORIES 31
CHEMICALS 33
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MASTER TESTING LIST - 1992
Introduction
The Master Testing List (MTL) is an important component of
the Existing Chemicals Program (ECP) in EPA's Office of Pollution
Prevention and Toxics. The ECP is responsible for assessing and
managing health and environmental risks that may be posed by
"existing" chemicals. For more information about the ECP refer
to Appendix I (EPA's Existing Chemicals Program - An Overview.)
EPA has been using the MTL since 1990 to set fits chemical
testing agenda. Section 4 of the Toxic Substances Control Act
(TSCA) gives EPA the authority to require chemicals manufacturers
and processors to test chemicals. Under Section 4, EPA has the
authority to require testing after finding that (l).a chemical
substance may present an unreasonable risk of injury to human
health or the environment, or the chemical is produced in
substantial quantities which could result in significant or
substantial human or environmental exposure, and <(2) available
data to evaluate the chemical are inadequate, and (3).testing is.
needed to develop the necessary data. EPA's.Chemical Testing
Program also continues to work with industry to develop test data
by way of consent orders and voluntary testing agreements.
The purposes of the MTL are to (l) identify; chemical testing
needs of the Federal Government (including EPA) and international
programs of interest to the U.S., (2) focus-limited EPA resources
on the highest priority chemical testing needs, (3) identify and
publicize EPA's testing priorities for industrial chemicals, (4)
obtain broad public comment on EPA's Chemical Testing Program and
its priorities, and (5) encourage initiatives by industry to
provide EPA with the priority data needs identified on the MTL.
Since 1990, EPA has (1) added 222 specific chemicals and 9
categories to the MTL, (2) deleted 45 chemicals from the MTL, (3)
proposed testing for 113 chemicals via proposed rulemaking under
TSCA Section 4; (4) required testing for 6 specific chemicals and
1 category (carpet/carpet products) via final TSCA Section 4 test
rules, negotiated consent orders or voluntary testing agreements,
and (5) made risk assessment/management decisions on 41 chemicals
based on final TSCA Section 4 test results received. Further,
159 chemicals listed on the MTL are now being tested under the
Screening Information Data Set (SIDS) program, an international
voluntary testing program developed under the aegis of the
Organization for Economic Cooperation and Development (OECD).
Members of the U.S. chemical industry have agreed to test 39 of
these chemical substances while other OECD member countries are
testing the remainder. This effort addresses the testing needs
for international high production volume chemicals.
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The .MTL now contains over 320 specific chemicals and 9
categories and presents EPA's Chemical Testing Program priorities
for 1992-1994.
I. ADDITIONS TO THE MTL
A. Specific Chemical Substances
The 222 chemicals added to the MTL are as follows:
o 106 chemicals from the OECD's SIDS testing program;
o 14 chemicals designated by the Interagency Testing Committee
(ITC) in its 27th and 28th Reports;
o 66 chemicals from the "Glycidol and Glycidol Derivatives"
category designated by the ITC in its 3rd Report and which
were the subject of a proposed TSCA Section 4 test rule
(56 FR 57144; November 7, 1991);
o 12 chemicals from the "Aryl Phosphates" category designated
by the ITC in its 2nd Report and the subject of a proposed
TSCA Section 4 test rule (57 FR 2138; January 7, 1992);
o 12 chemicals from the proposed TSCA Section 4 Multi-Chemical
Test Rule for Developmental and Reproductive Toxicity
(56 FR 9092; March 4, 1991),
o 10 chemicals from the proposed TSCA Section 4 Multi-Chemical
Test Rule for Neurotoxicological Effects (56 FR 9105;
March 4, 1991);
o Refractory Ceramic Fibers (RCF) monitoring to obtain
exposure data on RCF levels in industrial environments
resulting from RCF manufacture, processing and end-use.
o Formaldehyde emissions characterization in new conventional
and manufactured housing that contain formaldehyde-emitting
pressed wood building materials and products. This effort
will also involve characterization of the rate at which
formaldehyde levels decrease in these indoor environments.
B. Categories
The following 9 categories have been targeted by the Agency
for testing action. Work is currently underway to identify the
specific chemical substances in each category and the type(s) of
testing that should be pursued.
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Persistent Bioaccumulators
Many chemicals that combine persistence and bioaccumulation
have been found to present significant environmental
problems. Emerging concerns in EPA, especially in the
Office of Water, focus on sediments contaminated with
chemicals having these characteristics. OPPT plans to
require development of environmental fate and ecotoxicity
test data on these chemicals to support a more comprehensive
risk assessment. OPPT is in the process of identifying the
set of. .chemicals that will be handled under this effort.
New Chemicals Program Categories of Concern
EPA's New Chemicals Program has established 40 chemical
categories whereby TSCA section 5(e) risk determinations
have been made based upon health or environmental concerns
identified through structure-activity relationships (SAR).
These categories were established to simplify the TSCA
Section 5 regulatory process and represent part of a general
effort by EPA to promote the development of safer chemicals.
As part of this activity, EPA will work with companies to
identify and obtain the test data needed to better define
the limits of each category and to improve the understanding
of risks (hazard and exposure) that may be presented by TSCA
section 5 "Pre-Manufacture Notification" (PMN) substances
within these categories.
EPCRA Section 313 ("TRI Screening")
The Toxics Release Inventory (TRI) was established under
section 313 of the "Emergency Planning and Community Right-
to-Know Act" (EPCRA). Under this effort, an as yet
undefined subset of TRI chemicals that are produced and
released in high volumes will be evaluated and screening
level testing developed using the OECD SIDS"model. Current
efforts focus on a possible voluntary program organized by
the Chemical Manufacturers Association fCMA) .and possibly
other trade associations to provide the needed information
and testing.
CAAA Section 112 "Air Toxics"
Data are needed by EPA's Office of Air and Radiation (OAR)
to determine the "residual risk" posed by the 189 chemicals
listed under section 112 of the Clean Air Act Amendments of
1990. The 1992 MTL includes this category of chemicals,
although only a subset will have testing proposed for them
over the next several years.
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SARA Section 104 "Priority Data Needs"
Section 104 of the Superfund Amendments and Reauthorization
Act (SARA) requires EPA and the Agency for Toxic Substances
and Disease Registry (ATSDR) to list chemicals frequently
identified in Superfund sites. ATSDR is charged with the
preparation of "Toxicological Profiles" for these chemicals,
identifying data gaps and research needs, and developing a
testing/research program. When and where appropriate, TSCA
authorities are to be used to obtain the necessary data. To
date., 250 chemicals, have been listed under section .104 of
SARA. Toxicological Profiles have been completed on 110 out
of the 250 chemicals listed in SARA section 104 and cover a
total of 195 individual chemicals. The reason for the
apparent discrepancy is that a single chemical substance may
be listed but the Toxicological Profile covers several
chemical substances (e.g., the Toxicological Profile for
lead covers lead as well as several lead compounds). ATSDR
has developed priority data needs for a subset of the 250
chemicals. The industrial chemicals that are included in
this subset will be proposed for testing by EPA's Chemical
Testing Program over the next few years.
Respirable Fibers
Man-made and naturally-occurring fibers with diameters less
than 3.5 micrometers that can enter the small airways of the
lower respiratory tract and survive in biological systems
for long periods of time can present significant health
concerns. EPA is assessing the potential risks associated
with the production and use of synthetic and naturally-
occurring respirable fibers and products made from such
fibers. The testing likely to be proposed by EPA will focus
on health effects via inhalation and better characterization
of exposure.
Indoor Air Source Characterization -
Carpet/Carpet Products
An agreement has been reached to generate the test data
needed for characterization of Total Volatile Organic
Compound (TVOC) emissions from carpets and carpet-related
products. The emissions testing program was developed via
EPA's Carpet Policy Dialogue and testing was initiated in
1991. This effort involves testing to determine the TVOC
emissions from carpet, carpet cushion, and carpet adhesives.
(See 56 FR 67317; December 30, 1991)
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Indoor Air Source Characterization -
Interior Architectural Coatings
OPPT and EPA's Office of Air and Radiation are coordinating
efforts to characterize specific chemical emissions and
total emissions from indoor air sources such as paints,
varnishes and other coatings.
Polychlorinated Dioxins/Furans in Wood Pulp/Paper Mill Sludge
Polychlorinated dioxins and furans (D/F) are produced when
wood pulp is bleached with chlorine or chlorine-derivative
compounds. The sludge that results from the wastewater
treatment process in pulp and paper mills has been found to
be contaminated with D/F. The Agency is concerned about the
possible adverse human health and environmental risks posed
by the disposal of this sludge through land application and
has determined that additional testing and monitoring data
to evaluate such risks are needed. The testing program
could include determination of D/F concentrations in pulp
and paper mill sludge and an evaluation of the environmental
fate and ecological effects of D/F in this type of sludge.
C. NOTE
Also see the discussion in Part III.A.3. concerning changes
in the definitions of how chemicals will be removed from the MTL.
These changes have resulted over 20 chemical substances that
should have appeared, but did not appear, in the 1990 MTL and are
now included in the MTL for 1992.
H. DELETIONS FROM THE MTL
A total of 45 chemical substances have been deleted from the
MTL for the reasons set forth below.
The Interagency Testing Committee (ITC) has withdrawn the
quaternary ammonium compounds (designated for testing in the
ITC's 22nd Report) and plans to reevaluate the testing need(s)
and method(s) for these substances. Therefore, the following 4
quaternary ammonium compounds have been removed from the MTL:
Chemical Name CAS Registry Number
Imidazolium Quaternary Ammonium Compound 68142-86-1
Ethoxylated Quaternary Ammonium Compound 68410-69-5
Ethoxylated Quaternary Ammonium Compound 68413-04-7
Imidazolium Quaternary Ammonium Compound 72623-82-6
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Due-to the fact that the Agency has received, reviewed and
accepted the results of all tests required under TSCA Section 4,
the following 41 chemicals have been deleted from the MTL:
Chemical Name
CAS Recristrv Number
Propylene oxide 75-56-9
Isophorone 78-59-1
1,2-Dichloropropane 78-87-5
Methyl ethyl ketone * 78-93-3
Biphenyl 92-52-4
o-Cresol * 95-48-7
Cumene 98-82-8
p-Cresol 106-44-5
1,4-Dichlorobenzene 106-46-7
Methyl isobutyl ketone *,# 108-10-1
m-Cresol 108-39-4
Cyclohexanone * 108-94-1
Diethylenetriamine * 111-40-0
Diethylene glycol butyl ether 112-34-5
Triethylene glycol monomethyl ether * 112-35-6
Oleylamine * 112-90-3
Tetrafluoroethene 116-14-3
Hexafluoropropene * 116-15-4
2,4-Dinitrotoluene * 121-14-2
2-Phenoxyethanol 122-99-6
Hydroquinone * 123-31-9
Diethyleneglycol butyl ether acetate 124-17-4
2-Mercaptobenzothiazole * 149-30-4
2-Ethylhexanoic acid * 149-57-5
2,6-Dinitrotoluene 606-20-2
1,3-Dioxolane 646-06-0
Antimony Sulfide 1345-04-6
Disperse Blue 79 3618-72-2
2-Phenoxyethanol acetate 6192-44-5
Antimony 7440-36-0
Diisodecylphenyl phosphite 25550-98-5
C-9 Aromatic Mixture NONE
Chlorinated Paraffins (9 materials of various NONE
levels of chlorination and chain lengths)
* These chemical substances are also under OECD's SIDS program
listed separately.
# Methyl isobutyl ketone is also on the proposed TSCA Section 4
neurotoxicity end-point rule listed separately.
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. FORMAT CHANGES IN THE MTL FOR 1992
A. Comments Submitted by Interested Parties
EPA bases its testing priorities on broad input from all
those who have a stake in EPA's Existing Chemicals Program,
including other offices at EPA, other Federal agencies, the
Organization for Economic Cooperation and Development (OECD),
environmental groups, public interest groups, unions, chemical
companies, and private citizens. Availability of the .199,1 .MTL
and the date for a public meeting were announced in the Federal
Register (56 FR 42055, August 26, 1991). EPA received written
comments, and these and other issues were discussed at the public
meeting. In response to public comments, the MTL has been
restructured; these structural changes are summarized below.
Other issues raised via the public comment process can be found
in Appendix II.
1) Status in the Testing Process
A status code now indicates a chemical's progress through
the four stages of the testing process. Status code (A) is
assigned to chemicals when they are added to the MTL; (S) is
assigned to chemicals for which EPA is starting development of a
proposed test rule or negotiation of a consent agreement; (F) is
assigned to chemicals for which EPA is developing a final test
rule; and (T) is assigned to chemicals that are under test via a
voluntary agreement, consent order, or final test rule. The year
in which a chemical is expected to complete its current stage and
move to the next stage of the process is also shown on the list.
2) Testing Endpoint Indicators
Testing needs have now been organized into three general
categories of endpoints: health effects (Health), environmental
effects (Environ), and/or chemical fate (Fate). Additional
information on specific testing needs and codes is contained in
Table 2 on page 10.
3) Chemicals Removed Upon Receipt of All Test Data
The 1991 version of the MTL indicated that EPA would remove
chemicals after a final rule is published, but would continue to
list voluntary testing cases until the data were received. EPA
agrees with a number of comments about the inequity of this
.approach, and will leave chemicals on the MTL until all required
tests are completed and final reports are received and accepted
as adequate by EPA. Further, EPA will remove chemicals from the
MTL if the testing priority is significantly reduced, as was the
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case with-the quaternary ammonium compounds discussed previously.
As the result of this procedural change, more than 20 chemicals
which should have appeared, but did not appear, on the 1990 MTL
are now included in the 1992 MTL.
B) FORMAT, HEADINGS AND CODES USED IN THE MTL
The chemicals listed on the 1992 MTL are ordered by the
source of the testing need. In addition, the MTL includes an
index ordered by Chemical Abstract Service (CAS) Registry Number.
A description of the MTL columns as they are-ordered from left to
right follows.
CAS No.: This unique identifier of up to 9 digits is assigned
to chemicals by the Chemical Abstract Service (CAS). CAS numbers
are not available for several chemicals (e.g., commercial hexane)
and all categories on the MTL. Chemicals lacking CAS numbers are
listed at the beginning of the CAS-ordered index of MTL entries.
Chemical Name: The common chemical name used by EPA.
Source: The chemical substances and categories listed on the MTL
have been recommended for testing by sources from within EPA,
outside agencies, and the international toxics community. For
several chemical substances, several sources were responsible for
the testing recommendation. All sources are listed separately in
the CAS-ordered index to the MTL and include the following:
CPSC - U.S. Consumer Product Safety Commission
FTC - Interagency Testing Committee (ITC). The ITC was
created under TSCA to recommend chemicals for testing. The
ITC recommends chemicals in biannual reports to the EPA
Administrator. This code also indicates the ITC report
number in which a chemical substance was recommended for
testing.
OAR - Office of Air and Radiation, USEPA.
OECD - The Organization for Economic Cooperation and
Development. OECD member nations agreed that certain high
production volume chemicals should have a base set of
screening level test data available. These data are
referred to as the Screening Information Data Set (SIDS).
OECD considered groups of chemical substances in three
phases (1, 2, and 3); the number after the country code (see
the following section) denotes the phase.
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Country: This column (when it appears) identifies the OECD
country sponsoring the chemicals identified for testing
under the OECD SIDS testing program. Under this voluntary
cooperative program, a country prepares a data summary or
"Dossier" and conducts testing to provide missing SIDS data.
The country (or in some cases, countries) handling the
chemical is identified by a 2-letter code. The codes and
corresponding countries are listed in Table 1 below.
Table 1. OECD Countries and Codes
OEC0
" % <*»imy
Austria
Belgium
Canada
Switzerland
Germany
Denmark
Finland
France
Italy
Japan
Netherlands
Norway
Sweden
United Kingdom
United States
COUNniY*
<*>DB *
AT
BE
CA
CH
DE
DK
FI
FR
rr
JP
NL
NO
SE
UK
US
OPPT - Office of Pollution Prevention and Toxics, USEPA.
OPPT has identified chemicals requiring testing through its
Existing Chemicals Program. Some of the OPPT chemicals are
in the following multi-chemical rules:
o Neurotoxicity Endpoint Rule (N);
o Developmental/Reproductive Toxicity Endpoint Rule (D); and
o Dioxin/Furan Rule (D/F).
OW - Office of Water, USEPA.
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Year Added: The calendar year in which a chemical substance or
category was added to the MTL.
Status: Status code (A) is assigned to chemicals when they are
added to the MTL; (S) is assigned to chemicals for which EPA is
initiating development of a proposed test rule or negotiation for
a consent agreement; (F) is assigned to chemicals for which EPA
is developing a final test rule; and (T) is assigned to chemicals
under test via a voluntary agreement, consent order or final test
rule. The estimated date for completion of the current stage in
the chemical testing process is indicated by a 2 digit year code.
For example, the entry "S/93," indicates that the proposed rule
or a consent order is under development and is expected to be
completed (and final rulemaking is expected to begin) in 1993.
Testing Needs: The last 3 columns indicate specific testing needs
for health effects (Health), environmental effects (Environ) and
environmental fate (Fate). Table 2 below lists the codes for
specific testing needs recommended for chemicals on the 1992 MTL.
Table 2. Testing Need Codes
Health Effects
ACUTE
CARC
CHR
DEVEL
DNEURO
EPID
IMUN
MUTA
NEURO
PK
PCHR
REPRO
SCHR
SIDS
OTHR
Acute toxicily
Carcinogenicily
Chronic Toxicily
Developmental Toxicity
Developmental Neuro-
toxicity
Epidemiology
Immunotoxicity
Mulagenicity
Neuroloxicity
Pharmocokinetics
Prechronic Toxicity/ 14-28
day
Reproductive Toxicity
Subchronic Toxicity/ 90 day
Screening Data
Other
Environmental Effects
ACUTE
CHR
SIDS
OTHR
Acute toxicity
Chronic toxicily
Screening Data
Other
Environmental Fate
BIOC
DEGR
MONIT
PCHM
TSPT
SIDS
OTHR
Bioconcentration
Biodegradation
Monitoring
Physical Chemical Property
Transport/ Transformation
Screening Data
Other
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IV. PARTICIPATING IN THE CHEMICAL TESTING PROGRAM
How to Submit Information and Comments
Existing test data, as well as any suggestions for subsequent
versions of the MIL should be sent in triplicate to the TSCA
Public Docket (TS-793), Attn: TSCA Section 4 Master Testing List,
Office of Pollution Prevention and Toxics, U.S. Environmental
Protection Agency, 401 M Street SW., Washington, DC 20460.
How to Obtain Additional Information
For additional information, contact Susan Hazen, Director,
Environmental Assistance Division (TS-799), Office of Pollution
Prevention and Toxics, U.S. Environmental Protection Agency, 401
M St SW, Washington DC 20460, (202) 554-1404, TDD (202) 554-0557.
EPA is making test results and the results of the Agency's review
of test data available to the public through summaries that are
added to TSCATS (TSCA Test Submissions), a publicly accessible
computerized data base. In addition, information about testing
decisions resulting from Risk Management meetings are contained
in the administrative record, a central collection point
established by OPPT for materials on each chemical handled by
OPPT's Existing Chemical Program. Contents of the administrative
record include the following:
o a screening dossier containing relevant exposure and hazard
information, recommendations from the screening work group,
and the supporting rationale for that decision;
o summaries of major studies cited in the screening dossier;
o summaries of RM meetings;
o any letters of concern to industry or others and replies;
o comments or correspondence from other parties outside EPA.
The public can access the administrative record in the following
ways:
1. In person, by going to room G-004 of the Northeast Mall,
EPA Headguarters, at 401 M Street SW., Washington, D.C.
from 8:00 a.m. to noon and 1:00 p.m. to 4:00 p.m. Monday
through Friday (photocopy facilities are available); or
2. By writing to TSCA Public Docket (TS-793), Attention: RM1
Process, Office of Pollution Prevention and Toxics, U.S.
Environmental Protection Agency, 401 M Street SW.,
Washington, D.C. 20460.
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APPENDS I.
EPA'S EXISTING CHEMICALS PROGRAM: AN OVERVIEW
What are "existing chemicals"?
The approximately 70,000 chemicals that can be commercially
produced or used ..under .the..Toxic .Substances Control Act (.TSCA)
are known as "existing chemicals." These chemicals are listed on
the TSCA Inventory. As described below, the Existing Chemicals
Program focusses on approximately 14,000 chemicals (other than
polymers) that are produced in quantities of more than 10,000
pounds per year.
Under what authority does EPA regulate existing chemicals?
TSCA, enacted in 1976, gives EPA authority to gather information
about the toxicity of existing chemicals and the extent to which
people and the environment are exposed to them, to assess whether
those chemicals pose unreasonable risks to humans and the
environment, and to take appropriate actions to control
unreasonable risks. (TSCA also requires that EPA review most new
chemicals before they are manufactured.)
The law exempts eight product categories from TSCA regulatory
authorities: pesticides, tobacco, nuclear material, firearms and
ammunition, food, food additives, drugs, and cosmetics. Most of
these product categories are regulated under other federal laws.
What is the Existing Chemicals Program?
The Existing Chemicals Program is in EPA's Office of Pollution
Prevention and Toxics (OPPT). The program screens, establishes
testing requirements for, assesses, and develops strategies for
managing risks posed by chemicals currently in production or use.
Risk management encompasses any actions, regulatory or non-
regulatory, to reduce or eliminate the likelihood of harm to
human health or the environment.
OPPT has recently revised Existing Chemicals Program policies and
procedures. These revisions are directed toward
• enhancing the program's productivity—in terms of both the
number and effectiveness of risk management actions taken;
• increasing public participation in the program;
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• incorporating the concept of pollution prevention into all
stages of the program; and
• integrating program priorities as closely as possible with
agency-wide environmental risk-reduction priorities.
To do this, OPPT will
• focus on areas of highest risk;
• direct its efforts toward "clusters" of chemicals—groups
of chemicals with common characteristics; and
• apply a wide range of approaches to risk management, both
regulatory and non-regulatory, including, for example,
providing the affected public with better information
about chemicals and their potential risks.
How does the new Existing Chemicals Program work?
The fundamental elements of the new program are described below.
RISK MANAGEMENT ONE (RM1)
A hallmark of the new Existing Chemicals Program is flexibility—
flexibility to take quick, early action to reduce risk whenever-
possible. The Risk Management One (RM1) phase of the program is
a framework for ensuring that fact-finding and risk-management
activities begin at the earliest possible time.
Initial Screening
The first phase of RM1 is initial screening to identify potential
health and environmental risks of chemicals and to propose
candidates for action under the Existing Chemicals Program. In
broad terms, the population of potential candidates consists of
the approximately 14,000 chemicals (other than polymers, which
are generally of lesser concern due to limited bioavailability)
on EPA's TSCA Inventory that are produced in quantities greater
than 10,000 pounds annually.
In addition to its own analyses and databases, OPPT uses a
variety of resources to identify likely candidates for action,
including other Federal agencies, other EPA offices,
international organizations, states, Indian tribes, and
environmental and labor groups. Initial screening activities
rely primarily on readily available data concerning potential
hazard and potential exposure.
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RM1 Committee
Chemicals identified as potential candidates for risk reduction
during initial screening next move to the RM1 Committee, which
consists of representatives from throughout OPPT. The RM1
Committee, in consultation with other EPA offices and other
Federal agencies when appropriate, has two tasks: (1) to reach
initial qualitative conclusions about the risk presented by each
chemical candidate identified during initial screening and (2) to
determine the next step for each candidate. Where further action
is needed, OPPT will notify industry of its concern through a
"letter of concern" and will open an administrative record on the
chemicals of concern to allow all members of the public to track
the written materials EPA is evaluating.
Whenever possible, the program will take immediate steps to
reduce exposures to chemicals found during initial screening to
pose potential risk by (1) alerting industry and the public to
the problem and (2) promptly initiating actions to limit
exposures. Actions at this stage may include encouraging
voluntary pollution prevention or other control activities by
industry; listing the chemical on the Toxics Release .Inventory (a
national inventory, established by the Emergency Planning and
Community Right-to-Know Act, of annual releases of toxic
chemicals from manufacturing facilities); acquiring additional
information about the chemical under TSCA authorities; requiring
notification of EPA before the chemical is manufactured for any
new use; or referring the chemical to another Federal agency for
risk management action.
In addition to taking any immediate action that is appropriate
and feasible, the RM1 Committee has four options for proceeding
with chemical candidates:
• Place the chemical on OPPT's Master Testing List, a list
of chemicals given priority consideration for testing.
This course is taken when there are significant
information needs regarding the chemical's hazard or
exposure potential. After testing is completed, the
chemical returns to the RM1 stage of the process to
determine whether it should be dropped from further
consideration or put on course for additional action; the
test results may be used in ongoing risk management
deliberations or regulatory development activities.
• Place the chemical on the Risk Reduction List. Chemicals
suspected of posing or known to pose significant risks are
placed on an action list, known as the Risk Reduction
List. Chemicals are not removed from this list until the
concerns they present have been fully addressed and
resolved.
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Place the chemical on the Regional Activities Track.
Chemicals assigned to the Regional Activities Track are
those for which concern is limited to a few discrete
geographical areas or those for which control activities
reguire close coordination with state or local
authorities. When a chemical of concern is identified
that meets either or both of these criteria, OPPT
immediately notifies all appropriate EPA regional offices
and provides them with any support necessary to address
the concern.
Drop the chemical from the list of candidates for further
fact-finding or risk-management activities. Decisions to
drop are made when early fact-finding fails to indicate a
significant basis for concern or need for additional
action. (If OPPT subsequently receives new information
about a chemical that has been "dropped," however, that
chemical may reenter RM1.)
RISK MANAGEMENT TWO (RM2)
Risk Management Two (RM2) is the second phase of the Existing
Chemicals Program. The activities in this phase of the program
focus on (1) improving understanding about hazards posed by and
levels of exposure to particular chemicals and (2) developing and
adopting strategies to reduce or eliminate risks posed by
individual chemicals to human health or the environment.
Selecting Chemicals for RM2 Action
The Risk Reduction List is the bridge between RM1 and RM2. RM2
begins when a chemical is selected from the Risk Reduction List
for review. In general, the following criteria determine the
order in which chemicals move from the Risk Reduction List to
RM2: (1) the chemical's potential or known toxicity; (2) the
potential or known exposure to the chemical; and (3) the extent
to which pollution prevention can be achieved.
RM2 Investigation
When a chemical moves from the Risk Reduction List to RM2, OPPT
staff review existing information about the chemical and the risk
it presents, identify options to address the risk, and determine
what information is needed to select the most effective option.
Pollution prevention options are carefully considered at this
stage and may be recommended to industry for immediate voluntary
adoption. Other interested EPA offices and federal agencies are
also actively involved in this phase.
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RM2 Decision
After completing the RM2 investigation and considering any
information provided by the public, OPPT management reconvenes to
select a strategy to manage risks posed by the chemical in
question. The strategy selected may contain one or more of a
wide range of actions, including:
• initiating a public awareness campaign;
• calling for voluntary action by industry;
• referring the chemical to another EPA program office,
regional office, or other federal agency for action;
• stepping up enforcement of existing regulations;
• developing regulations, such as labeling requirements,
restrictions on processing or use, or bans (regulations
developed under TSCA follow standard EPA rulemaking
procedures, including provisions for public
participation); and
• dropping from further consideration, if warranted by
information that is developed during the RM2
investigation.
How can the public get involved in EPA's existing chemicals
process?
A central goal of the Agency's revitalized Existing Chemicals
Program is that its work be carried out with as much public
involvement as possible. OPPT invites and encourages active
public participation, via comment and consultation, throughout
the process. The Existing Chemicals Program also welcomes
nominations of chemical candidates for screening and/or review
and for inclusion on the Master Testing List, as well as
suggestions for early pollution-prevention and risk-reduction
actions.
The vehicle that permits full public participation in the
existing chemicals process is the administrative record, a
central collection point established by OPPT for materials on
each chemical under consideration. The administrative record
includes the following documentation:
• a screening dossier containing relevant exposure and
hazard information, recommendations from the screening
workgroup, and the supporting rationale for that decision;
• summaries of major studies cited in the screening dossier;
16
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• summaries of RM1 and RM2 meetings;
• any letters of concern to industry or others and replies;
• comments and other correspondence from other parties
outside of EPA.
The public can gain access to the RM administrative record in the
following two ways:
1. In person, by going to room G-004 of the Northeast Mall,
EPA Headquarters, at 401 M Street SW., Washington, D.C.,
between 8:00 a.m. and noon and 1:00 p.m. and 4:00 p.m.
Monday through Friday (facilities for photocopying are
available); or
2. By writing to the TSCA Public Docket (TS-793), Attention:
RMl Docket, Office of Pollution Prevention and Toxics,
U.S. Environmental Protection Agency, 401 M Street, S.W.,
Washington, D.C. 20460.
NOTEt A flow diagram of EPA's Existing Chemicals Program appears
on the following page.
17
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OPPT EXISTING CHEMICAL PROGRAM
COMPIETED TESTING
00
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APPENDIX n. PUBLIC COMMENTS/ISSUES
A) The MTL Should Include 3 Lists and a Process to Set Priorities
Representatives of the chemical industry recommended that
EPA expand the MTL to include three lists: a list of testing
candidates; a list of those chemicals on which EPA is currently
working -(this would be similar to the present MTL); and a list
of chemicals that have completed testing. In a related comment,
the chemical manufacturers questioned how EPA will set priorities
and select chemicals for the MTL.
EPA believes the MTL should remain a single list
containing chemicals for which EPA plans to initiate work within
the next several years. This can be explained by describing how
the MTL is integrated into the OPPT Existing Chemicals Program
(ECP). Briefly, the program works like this: OPPT receives
requests for test data and nominations for additional testing
from other EPA offices, Federal and state agencies, the ITC, and
other sources outside the program. OPPT screens these chemicals
and others identified by OPPT through its ECP. During this
screening, OPPT determines whether (1) additional information is
needed concerning a chemical's hazard and/or exposure potential,
and (2) determines the relative priority of the action. Those
chemicals judged to present high priority testing needs will be
added to the MTL. Prioritization decisions will consider factors
such as: the extent which testing addresses high-risk or high-
exposure situations; the potential for future regulatory or
voluntary activities to reduce risks or prevent pollution;
Congressional mandates; existence of a practical use and need for
the data; and the existence of multiple needs for the data. When
testing is completed, the data are evaluated via OPPT's ECP. To
learn more about the ECP, refer to Appendix I.
B) Categories are Helpful But Confusing
Some commentors indicated that they are confused by the
use of chemical categories. For example, the categories may be
inadequately defined, chemicals may be in more than one category,
and some categories do not specify the chemicals included. The
1992 MTL includes only those categories selected for testing
action by OPPT. These categories are discussed in the section
entitled "Additions to the MTL."
19
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C) The MTL Should Include All Testing
Several commentors recommended expanding the MTL to
include all testing for all industrial chemicals, including, for
example, testing being conducted by the National Toxicology
Program. EPA has chosen to keep the MTL limited to testing
related to authorities under section 4 of TSCA and other OPPT
coordinated voluntary testing activities such as the Screening
Information Data Set (SIDS) testing effort under the aegis of the
Organization for Economic Cooperation and Development (OECD).
20
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1992 Master Testing List
Index of Chemicals Sorted by CAS Number
CAS No.
Chemical Name
Source
NONE Commercial hexane ITC/16
NONE -. Dioxins, polyhalogenated dibenzo-p- ....... OPPT/DF
NONE Furans, polyhalogenated dibenzo- OPPT/DF
50-00-0 Formaldehyde OPPT
50-81-7 L-Ascorbic acid OECD/3
57-10-3 Hexadecanoic acid OPPT/D
57-13-6 Urea OECD/2
59-67-6 Pyridinecarboxylic acid. 3- OECD/1
60-29-7 Diethyl ether OPPT/N
67-63-0 Isopropanol ITC/20
67-64-1 Acetone -. OPPT/N
67-64-1 Acetone ITC/28
70-55-3 Benzenesulfonamide. 4-methyl- OECD/1
71-36-3 Butanol. 1- OPPT/N
71-36-3 Butanol. 1- ITC/28
71-55-6 Trichloroethane, 1.1.1- ITC/2
74-85-1 Ethylene OECD/2
74-87-3 Chloromethane OW
74-97-5 Bromochloromethane OPPT/D
75-00-3 Chloroethane OW
75-02-5 Vinyl fluoride ITC/7
75-15-0 Carbon disulfide OPPT/D
75-34-3 Dichloroethane. 1,1- OW
75-35-4 1,1-Dichloroethytene . OAR
75-38-7 Vinylidene fluoride ITC/7
75-54-7 Silane. dichloromethyl- OECD/1
75-69-4 Fluorotrichloromethane OW
75-77-4 Silane. chlorotrimethyl- OECD/1
75-78-5 Silane, dichlorodimethyl- . OECD/1
75-79-6 Silane, trichloromethyl- OECD/1
75-86-5 Acetone cyanhydrin OECD/2
75-91-2 Hydroperoxide, 1,1-dimethylethyl- OECD/1
75-98-9 2,2-Dimethylpropanoic acid OECD/3
76-03-9 Trichloroacetic acid OECD/2
77-99-6 Propanediol, 2-ethyl-2-(hydroxymethyl)-, 1,3- OECD/1
78-33-1 Phosphate, tris(tert-butylphenyl) ITC/ 2
78-40-0 Triethyl phosphate OECD/1
78-83-1 Isobutyl alcohol ITC/28
21
-------
1992 Master Testing List
Index of Chemicals Sorted by CAS Number
CAS NO.
Chemical Name
Source
78-83-1 Isobutyl alcohol OPPT/N
78-84-2 Propanal. 2-methyl- OECD/1
78-93-3 Methyl ethyl Jcetone OECD/2
78-97-7 Propanenitrile, 2-hydroxy- OECD/2
79-00-5 1,1.2-Trichloroethane OW
79-10-7 Acrylic acid ITC/27
79-11-8 Chloroacetic acid OECD/2
79-31-2 Methylpropanoic acid, 2- OPPT/D
79-34-5 Tetrachloroethane, 1,1.2.2- OW
79-92-5 Camphene OECD/1
79-94-7 Tetrabromobisphenol A OECD/3
79-94-7 Tetrabromobisphenol A OPPT/DF
80-05-7 Bisphenol A OECD/3
80-43-3 Dicumyl peroxide OECD/2
81-11-8 Benzenesulfonic acid, 2.2'-(1,2-ethenedi- OECD/3
82-45-1 1 -Aminoanthraquinone OECD/3
87-10-5 Tribromosalicylanilide, 3.4',5- OPPT/DF
88-72-2 Nhrotoluene, 2- OECD/1
89-61-2 Benzene, 1,4-dichloro-2-nitro- OECD/3
92-70-6 2-Hydroxy-3-naphthoic acid OECD/3
95-48-7 o-Cresol OECD/2
95-54-5 Phenylenediamine, ortho- ITC/ 6
95-73-8 2.4-Dichlorotoluene OECD/2
95-80-7 Diaminotoluene, 2.4- OPPT/D
96-29-7 Methyl ethyl ketoxime ITC/19
97-65-4 Butanedioic acid, methylene- OECD/2
98-56-6 Benzene, 1 -chloro-4-(trifluoromethyl)- OECD/2
98-86-2 Acetophenone ITC/27
99-09-2 Nrtroaniline. 3- OECD/1
100-21-0 Terephthalic acid OPPT/D
100-21-0 Terephthalic acid OECD/2
100-40-3 Vinylcyclohexene, 4- ITC/27
100-52-7 Benzaldehyde OECD/3
101-54-2 1,4-Benzenediamine, N-phenyl- OECD/3
101-68-8 Methylenediphenyl diisocyanate. 4,4'- OECD/3
101-72-4 Benzenediamine. N-(1-methylethyl)-N'-phenyl-, 1,4- OECD/3
101-90-6 Resorcinol diglycidyl ether ITC/ 3
102-01-2 Acetoacetanilide OECD/3
102-71-6 Triethanolamine OECD/3
22
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1992 Master Testing List
Index of Chemicals Sorted by CAS Number
CAS No.
Chemical Name
Source
103-23-1 Di(2-ethylhexyl) adipate ITC/28
103-65-1 Propylbenzene, n- OW
104-76-7 Ethylhexanol. 2- OECD/3
104-76-7 Ethylhexanol. 2- OPPT/D
104-90-5 2-Picoline, 5-ethyl- OECD/3
104-94-9 Aniline. 4-methoxy- OECD/2
105-05-5 Benzene. 1.4-diethyl- OECD/2
105-76-0 Maleic acid, dibutyl ester OECD/2
105-99-7 Di-butyl adipate OECD/3
106-42-3 p-Xylene OECD/3
106-50-3 Phenylenediamine, para- ITC/6
106-90-1 Glycidyl acrylate ITC/ 3
106-91-2 Glycidyl methacrylate ITC/ 3
106-92-3 Allyl glycidyl ether ITC/ 3
106-98-9 Butene. 1- OECD/2
107-01-7 Butene, 2- OECD/1
107-13-1 Acrylonitrile OPPT/D
107-21-1 Ethylene glycol OECD/2
107-22-2 Glyoxal OECD/3
107-64-2 1-Octadecanaminium, N.N-dimethyl-N-octad OECD/3
107-66-4 Phosphoric acid, dibutyl ester OECD/2
108-01-0 Dimethylaminoethanol OECD/2
108-10-1 Methyl isobutyl ketone OECD/2
108-10-1 Methyl isobutyl ketone OPPT/N
108-24-7 Acetic anhydride OECD/2
108-44-1 m-Toluidine OECD/3
108-45-2 Phenylenediamine. meta- ITC/6
108-67-8 Trimethylbenzene. 1.3,5- OW
108-78-1 Melamine OECD/2
108-83-8 Heptanone, 2.6-dimethyl-, 4- OECD/2
108-89-4 Pyridine. 4-methyl- OECD/3
108-94-1 Cyclohexanone OECD/3
108-95-2 Phenol ITC/27
108-98-5 Thiophenol ITC/28
108-99-6 Pyridine. 3-methyl- OECD/2
109-06-8 Pyridine. 2-methyl- OECD/3
109-55-7 1 -Amino-3-dimethylamino propane OECD/2
109-69-3 Chlorobutane. 1- OECD/2
109-99-9 Tetrahydrofuran OPPT/N
23
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1992 Master Testing List
Index of Chemicals Sorted by CAS Number
CAS No.
Chemical Name
Source
110-27-0 Isopropyl myristate OECD/3
110-30-5 Octadecanamide, N.N'-1,2-ethanediylbis- OECD/3
110-80-5 Ethoxyethanol. 2- OPPT/N
110-82-7 Cyclohexane ITC/18
110-91-8 Morpholine OECD/3
111-11-5 Octanoic acid, methyl ester OPPT/D
111-40-0 Diethylenetriamine OECD/2
111-42-2 Diethanolamine OECD/2
111-46-6 Diethylene glycol OECD/3
111-66-0 1-Octane OECD/2
111-69-3 1.4-Dicyanobutane OECD/3
1.12-18-5 N.N-Dimethyldodecylamine OECD/2
112-24-3 Triethylene tetramine OECD/3
112-35-6 Ethanol, 2-[2-(2-methoxyethoxy) ethoxyl- OECD/3
112-41-4 1-Dodecene OECD/2
112-50-5 Triethylene glycol, monoethyl ether OECD/3
112-53-8 Dodecanol, 1- OECD/1
112-72-1 1-Tetradecanol OECD/3
112-90-3 9-Octadecen-1-amine, (Z)- OECD/3,
112-92-5 Octadecanol, 1- OECD/11
115-11-7 2-Methylpropene OECD/3
115-18-4 3-Buten-2-ol, 2-methyl- OECD/2
115-19-5 3-Butyn-2-ol. 2-methyl- OECD/2
115-86-6 Triphenyl phosphate ITC/ 2
115-96-8 Tris(2-chloroethyl)phosphate ITC/23
116-15-4 Hexafiuoropropene OECD/3
118-69-4 2,6-Dichlorotoluene OECD/3
118-75-2 Chloranfl OPPT/DF
118-79-6 2.4,6-Tribromophenol OPPT/DF
120-61-6 Dimethyl terephthalate ITC/28
120-61-6 Dimethyl terephthalate OECD/2
120-78-5 Benzthiazole disulfide OECD/3
120-80-9 Hydroxyphenol, o- OPPT/D
120-82-1 Trichlorobenzene. 1,2.4- ITC/3
121-14-2 Benzene. 1-methyl-2.4-dinitro- OECD/2
121-33-5 Vanillin OECD/3
121-69-7 Dimethylaniline. N.N- ITC/27
122-60-1 Phenyl glycidyl ether ITC/ 3
123-01-3 Dodecylbenzene OECD/3
24
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1992 Master Testing List
Index of Chemicals Sorted by CAS Number
CAS No.
Chemical Name
Source
123-30-8 Aminophenol, p- OPPT/D
123-31-9 Hydroquinone OECD/3
123-38-6 Propanal OECD/1
123-72-8 Butyraldehyde OECD/3
123-77-3 Diazenedicarboxamide OECD/3
123-86-4 Butyl acetate, n- OPPT/N
124-09-4 1,6-Hexanediamine OECD/2
124-18-5 n-Decane OECD/2
126-30-7 Propanediol. 2,2-dimethyl-, 1.3- OECD/1
126-58-9 1,3-Propanediol, 2.2'-[oxybis-(methylene) OECD/1
126-73-8 Tributyl phosphate ITC/18
126-80-7 1,3-Bis[3-(2,3-epoxypropoxy)-propyl]tetramethyldisiloxane ITC/ 3
126-99-8 Chloroprene OECD/2
127-19-5 Dimethylacetamide OECD/3
128-39-2 Di-tert-butylphenol ITC/18
128-39-2 Di-tert-butylphenol OECD/1
135-19-3 2-Napththol OECD/3
140-66-9 Phenol, 4-{1,1.3,3-tetramethylbutyl)- OECD/3
141-78-6 Ethyl acetate ITC/27
141-78-6 Ethyl acetate OPPT/N
141-79-7 Mesityl oxide ITC/ 4
141-79-7 Mesityl oxide OECD/3
143-33-9 Sodium cyanide ITC/27
147-14-8 C.I. Pigment Blue 15 OECD/1
149-57-5 Ethyl hexanoic acid. 2- OECD/2
151-21-3 Sodium lauryl sulfate OECD/2
156-43-4 Benzenamine, 4-ethoxy- OECD/1
294-62-2 Cyclododecane OECD/1
482-89-3 3H-lndol-3-one. 2-{1.3-dihydro-3-oxo-2H- OECD/2
504-60-9 Pentadiene. 1.3- OECD/1
512-56-1 Phosphoric acid, trimethyl ester OECD/3
527-60-6 Phenol, 2.4.6-trimethyl- OECD/2
536-90-3 Benzenamine, 3-methoxy- OECD/1
556-52-5 Glycidol ITC/ 3
556-67-2 Octamethylcyclotetrasiloxane OECD/1
576-26-1 Dimethylphenol. 2.6- ITC/27
584-03-2 Butanediol, 1.2- OECD/1
590-86-3 Butanal. 3-methyl- OECD/2
592-41-6 1-Hexene OECD/2
25
-------
1992 Master Testing Ust
Index of Chemicals Sorted by CAS Number
CAS No.
Chemical Name
Source
611-06-3
623-91-6
628-63-7
629-11-8
629-59-4
693-23-2
793-24-8
822-06-0
836-30-6
872-05-9
872-50-4
930-37-0
1000-82-4
1120-36-1
1163-19-5
1163-19-5
1241-94-7
1309-64-4
1330-78-5
1634-04-4
1675-54-3
1758-73-2
1854-26-8
1879-09-0
1912-24-9
2210-79-9
2224-15-9
2238-07-5
2402-79-1
2425-01-6
2425-79-8
2426-08-6
2431-50-7
2461-15-6
2461-18-9
2524-03-0
2524-04-1
2528-36-1
2530-83-8
ITC/22
ITC/25
Benzene. 2,4-dichloro-l-nitro-
2-Butenedioic acid <£)-. diethyl ester ...
Amyl acetate, n- OECD/3
Hexamethylene glycol OPPT/N
Tetradecane
Dodecanedioic acid ?^CD/2
1.4-Benzenediamine. N-(1.3-dimethylbutyl .... . .
Hexamethylene diisocyanate, 1,6-
Benzenamine, 4-nitro-N-phenyl- .
Decene. n- . . OECD/3
Methylpyrrolidone. N- OECD/2
Methyl glycidyl ether CPSC
Methylol urea '.'.'.'.'.'.'.'. 'TC/ 3
1-Tetradecene ' ' ' ' ITc/12
Decabromodiphenyl ether °1^2
Decabromodiphenyl ether
Ethylhexyl diphenyl phosphate, 2-
Antimony trioxide
Tricresyl phosphate '.'.'.'.'.'.'.'.'.'.'.'.'.'. IT°/4
Methyl tert-butyl ether '.'.'.'.'. 'TC/ 2
Bisphenol A diglycidyl ether 'TC/2°
Methanesulfinic acid, aminoimino- 3
2-lmidazolidinone. 4.5-dihydroxy-1.3-bis ncnn'/1
6-tert-Butyl-2,4-xylenol ... OECD/3
Atrazine '.'.".'.'.'. OECD/3
Cresyl glycidyl ether, o- OECD/2
Ethylene glycol diglycidyl ether I™.3
Diglycidyl ether " " ' _r 3
Tetrachloropyridine. 2.3.5.6- '.'.'.'.'.
Hydroquinone diglycidyl ether
Butanediol diglycidyl ether, 1,4- ..'.'.'.'.'.'.
Butyl glycidyl ether, n- TC/ 3
Butene. 2.3.4-trichloro-, 1- ITC/ 3
Ethylhexyl glycidyl ether. 2- '.'.'. °ECD/1
Lauryl glycidyl ether 3
Dimethyl chlorothiophosphate J[C/ 3
Diethyl chlorothiophosphate '.'.'.'.'.'.'.'.'.'. OECD/3
Di(n-butyl) phenyl phosphate '.'.'.'.'. |TC/D/3
Glycidoxypropyltrimethyoxysilane. gamma- .... . . ,TC/ 3
OECD/1
ITC/3
26
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1992 Master Testing List
Index of Chemicals Sorted by CAS Number
CAS No.
Chemical Name
Source
2581-34-2 Phenol. 3-methyl-4-nitro- OECD/2
2897-60-1 3-(Methyldiethoxysilyl)propyl glycidyl ether ITC/ 3
3039-83-6 Ethenesulfonic acid, sodium salt ... . OECD/2
3072-84-2 Tetrabromobisphenol A diglycidyl ether. 2,2',6.6'- ITC/ 3
3101-60-8 Butylphenyl glycidyl ether, p-tert- ITC/ 3
3188-83-8 2-Methylol-4.4'-isopropylidene-diphenol diglycidyl ether ITC/ 3
3194-55-6 Hexabromocyclododecane ITC/25
3209-22-1 Benzene, 1,2-dichloro-3-nhro- OECD/1
3568-29-4 Glycerol 1,3-diglycidyl ether ITC/ 3
3926-62-3 Acetic acid, chloro-, sodium salt OECD/2
4016-11-9 Ethyl glycidyl ether ITC/ 3
40.16-14-2 Isopropyl glycidyl ether ITC/ 3
4162-45-2 Tetrabromobisphenol-A-bis(ethoxyla OPPT/DF
4170-30-3 Crotonaldehyde ITC/22
4259-15-8 Phosphorodithioic acid, o.o-bis(2-ethyln- OECD/2
4461-52-3 Methoxymethanol OECD/2
4979-32-2 N,N-Dicyclohexyl-2-benzothiazolesulfenam OECD/3
5026-74-4 4-(Diglycidylamino)phenyl glycidyl ether ITC/ 3
5255-75-4 Nrtrophenyl glycidyl ether, p- ITC/ 3
5281-04-9 D and C Red No 7 OECD/2
5392-40-5 Citral OECD/3
5493-45-8 Diglycidyl ester of hexahydro-phthalic acid ITC/ 3
6178-32-1 p-Nonylphenyl glycidyl ether . . ITC/ 3
6386-38-5 Benzenepropanoic acid. 3,5-bis(1,1-di-methylethyD- OECD/1
6419-19-8 Phosphonic acid. [nitrilotris-(methylene)]tris- OECD/1
6742-54-7 Benzene, undecyl- OECD/3
6846-50-0 2,2.4-Trimethyl-1.3-pentanediol ester OECD/2
7195-45-1 Diglycidyl ester of phthalic acid ITC/ 3
7328-97-4 1,1.2,2-Tetra(p-hydroxyphenyl)-ethane tetraglycidyl ether ITC/ 3
7422-52-8 3-[Bis(trimethylsiloxy)methyl]-propyl glycidyl ether ITC/ 3
7665-72-7 Butyl glycidyl ether, tert- ITC/ 3
9011-05-6 Urea-formaldehyde resins/ formaldehyde ITC/12
11631-19-5 Decabromodiphenyloxide OPPT/DF
13236-02-7 Glycerol triglycidyl ether ITC/ 3
13561-08-5 Diglycidylphenyl glycidyl ether, 2,6- ITC/ 3
13674-84-5 2-Propanol. 1-chloro-. phosphate (3:1) OECD/3
14228-73-0 Bis(glycidyloxymethyl) cyclohexane. 1,4- ITC/ 3
15965-99-8 Hexadecyl glycidyl ether ITC/ 3
16245-97-9 Octadecyl glycidyl ether, n- ITC/ 3
27
-------
1992 Master Testing List
Index of Chemicals Sorted by CAS Number
CAS No.
Chemical Name
Source
17557-23-2 Neopentyl glycol diglycidyl ether ITC/ 3
17963-04-1 3-(Dimethylethoxysilyl)propyl glycidyl ether ITC/ 3
20217-01-0 . Dibromophenyl glycidyJ ether, 2,4-. . . . ITC/ 3
22421-59-6 Dibromo-4-methylphenyl glycidyl ether, 2.6- ITC/ 3
24800-44-0 Tripropylene glycol OECD/2
25155-23-1 Phosphate, trixylyl ITC/ 2
25265-77-4 Propanoic acid, 2-methyl-, monoester OECD/1
25327-89-3 Tetrabromobisphenol-A. ally! ether OPPT/DF
26444-49-5 Phosphoric acid, methylphenyldiphenyle OECD/2
26447-14-3 Cresyl glycidyl ether (mixed isomers) ITC/ 3
26761-45-5 Glycidyl ester of neodecanoic acid ITC/ 3
26967-76-0 Phosphate, tris(isopropylphenyl) ITC/ 2
27193-86-8 Dodecylphenol OPPT/D
28108-99-8 Isopropylphenyl diphenyl phosphate ITC/ 2
28629-66-5 Phosphorodithioic acid, o.o-diisooctyl OECD/2
29171-20-8 6-Octen-1-yn-3-ol. 3.7-dimethyl- OECD/1
29590-42-9 Iso-octyl acrylate OECD/1
29761-21-5 Isodecyl diphenyl phosphate ITC/ 2
32534-81-9 Pentabromodiphenyl ether ITC/25
32534-81-9 Pentabromodiphenyl ether OPPT/Dfl
32536-52-0 Octabromodiphenyl ether ITC/25
32536-52-0 Octabromodiphenyl ether OPPT/DF
32568-89-1 3-(2-Glycidyloxypropyl)-1-glycidol-5.5-dimethy!-hydantoin ITC/ 3
35243-89-1 Dibromopropyl glycidyl ether. 1,2- ITC/ 3
37853-59-1 Ethane, 1,2-bis(2,4,6-tribromophenoxy)- OPPT/DF
37853-59-1 Ethane, 1,2-bis(2,4,6-tribromophenoxy)- ITC/25
37971-36-1 Butanetricarboxylic acid, 1,2,4- OECD/1
38304-52-8 1.3-Bis(5.5-dimethyl-1-glycidyl-hydantoin-3-yl)-2-glycidyl ITC/ 3
38954-75-5 Tetradecyl glycidyl ether ITC/ 3
54208-63-8 Bisphenol F diglycidyl ether ITC/ 3
56803-37-3 Phosphate, tert-butylphenyl diphenyl ITC/ 2
60501-41-9 Oleyl glycidyl ether ITC/ 3
61578-04-9 Cumyiphenyl glycidyl ether, p- ITC/ 3
65652-41-7 Phosphate, bis(tert-butylphenyl) phenyl ITC/ 2
67786-03-2 [Bis(4-glycidyloxyphenyl)]-(2-glycidyl-oxyphenyl)methane ITC/ 3
68081-84-5 Alkyl (C10-C16) glycidyl ether ITC/ 3
68134-06-5 Dimethylbutyl glycidyl ether,. 1.3- ITC/ 3
68134-07-6 Methylheptyl glycidyl ether. 6- ITC/ 3
68517-02-2 Tris(4-hydroxyphenyl)propane-triglycidyl ether ITC/ 3
28
-------
1992 Master Testing List
Index of Chemicals Sorted by CAS Number
CAS No.
Chemical Name
Source
68609-96-1 Alkyl (C8-C10) glycidyl ether ITC/ 3
68609-97-2 Alkyl (C12-C14) glycidyl ether ITC/ 3
68611-64-3 Urea-formaldehyde resin ITC 12
68937-41-7 Phenol Isopropylated phosphate ITC/ 2
68959-23-9 Hexanetriol triglycidyl ether. 1,2,6- ITC/ 3
68987-80-4 Alkyl (C6-C12) glycidyl ether ITC/ 3
69155-42-6 1.1.1.3.5.7.7,7-Octamethyl-3.5-bis(6,7-epoxy-4-oxaheptyl)- ITC/ 3
71033-08-4 2.2-Bis[p-2-glycidyloxy-3-butoxypropyloxy)-phenyl]propane ITC/ 3
71808-64-5 Dimethoxysilane, (3-glycidoxy-propyl)(3-chloropropyl>- ITC/ 3
72319-24-5 2.2'-[{1-Methylethylidene)bis[4,1-phenyleneoxy-3,1-propanedioxy ITC/ 3
74398-71-3 1,2,3-Propanetriyl ester of 12-(oxiranylmethoxy)-9-octadecanoic acid ITC/ 3
75150-13-9 2.4-Dibromo-6-methylphenyl glycidyl ether ITC/ 3
84852-15-3 Nonylphenol. 4-branched OPPT
97380-66-3 Urea-formaldehyde resin ITC/12
142844-00-6 Refractory ceramic fibers OPPT
29
-------
1992 Master Testing List
Index of Sources By Alphabetical Order
Source Identity Page
Categories ...... 31
Consumer Product Safety Commission (CPSC) 33
Interagency Testing Committee (ITC) 33
Aryl Phosphates 33
Glycidol & Derivatives 34
Brominated Rame Retardants 39
Other ITC Chemicals 39
Office of Air and Radiation (OAR) 42
Office of Pollution Prevention and Toxics (OPPT) 42
Developmental and Reproductive Effects 43
Neurotoxicologic Effects 43
Dioxins/Furans 44
Office of Water (OW) 45
Organization for Economic Cooperation and Development (OECD) 46
Phase 1 46
Phase 2 47
Phase 3 50
Endnotes 53
30
-------
1992 Master Testing List
Categories
Category Name Source
Air Toxics OAR
Indoor Air Source OPPT
Characterization - Carpet
Yr
Added
1992
1991
Indoor Air Source
Characterization - Interior
Architectural Coatings
New Chemicals Program
Categories of Concern
OPPT & OAR 1992
OPPT
1992
Persistent
Bioaccumulators
OPPT
1992
Comment
Data needed to determine "residual risk" posed by
Hazardous Air Pollutants listed under section 112
of the Clean Atr Act Amendments.
Agreement has been reached to generate test data
needed for characterization of Total Volatile
Organic Compound (TVOC) emissions from carpets,
carpet cushions, and carpet adhesives. The
emissions testing program was developed via EPA's
Carpet Policy Dialogue; and testing was initiated in
1991. (56 FR 67317, December 30. 1991).
This effort will focus on developing data needed to
characterize specific chemical emissions and TVOC
emissions from indoor air sources such as paints,
varnishes, and other coatings.
EPA's New Chemicals Program has established 40
chemical categories whereby TSCA section 5(e)
risk determinations have been made based upon
health or environmental concerns identified through
structure-activity relationships (SAR). These
categories were established to simplify the TSCA
section 5 regulatory decision process and represent
part of a general effort by the Agency to promote
the development of safer chemicals. As part of
this activity, EPA will work with companies to
identify and obtain the test data needed to better
define the limits of each category and to improve
the understanding of the risks (hazard and
exposure) presented by TSCA section 5 "Pre-
Manufacture Notification" (PMN) substances within
these categories.
Chemicals that combine persistence and
bioaccumulation are being identified through
Structure Activity relationships (SAR) analysis.
Testing will likely focus on confirming
persistence/bioaccumulation potential and
characterizing environmental effects.
31
-------
1992 Master Testing List
Categories (continued)
Category Name
Polychlorinated
Dioxins/Furans in Wood and
Paper Pulp. Sludge
Respirable Fibers
SARA Section 104
TRI Screening
Yr
Source Added Comment
OPPT 1992 Polyhalogenated dioxins and furans (D/F) are produced
when wood pulp is bleached with chlorine or chlorine-
derivative compounds*- -The sludge resulting from the
wastewater treatment process in pulp and paper mills
have been found to be contaminated with D/F. The
Agency is concerned with risks to humans and the
environment from the disposal of this sludge through
land application, and has determined a need for
additional testing and monitoring data to evaluate the
risks. The testing program could include determination
of D/F concentrations in pulp and paper mill sludge and
an evaluation of the environmental fate and ecological
effects of D/F in this type of sludge.
OPPT 1992 EPA plans to investigate potential inhalation health
hazards and better characterize potential exposures to
synthetic and naturally-occurring respirable fibers.
OPPT 1992 Priority data needs on industrial chemicals identified by
ATSDR following preparation of Toxicological Profile
will be referred for handling by OPPT under TSCA
section 4.
OPPT 1992 High volume/high release chemicals on the Toxics
Release Inventory have been targeted for development
of screening level test data.
32
-------
CAS No.
872-50-4
78-33-1
115-86-6
1241-94-7
1330-78-5
2528-36-1
25155-23-1
26967-76-0
28108-99-8
29761-21-5
56803-37-3
65652-41-7
Chemical Nam*
Methylpyrrolidone, N-
Ptiosphate, tris(tert-butylphenyl)
Phosphate, triphenyl
Phosphate, ethylhexyl diphenyl 2-
Phosphate, tricresyl
Phosphate, di(n-butyl) phenyl
Phosphate, trixylyl
Phosphate, tris(isopropylphenyl)
Phosphate, isopropylphenyl diphenyl
Phosphate, isodecyl diphenyl
Phosphate, tert-butylphenyl diphenyl
Phosphate, bis(tert-butylphenyl)
phenyl
1992 Master Testing List
Chemicals
Yr
Source Added Status
xmsurre
CPSC
MiW«tjlau*A tt^ti*
Product Sara
90
brteregency Testing
ty Commission
F/93 CARC,
MUTA,
Committee
Health
: »«
rang EiKiputiiis
Environ
fate
!
NEURO, PK, SCHR
DEVEL, REPRO
Aryf Phosphates
ITC/2
ITC/2
ITC/2
ITC/2
ITC/2
ITC/2
ITC/2
ITC/2
ITC/2
ITC/2
ITC/2
92
92
92
92
92
92
92
92
92
92
92
F/93
F/93
F/93
F/93
F/93
F/93
F/93
F/93
F/93
F/93
F/93
DEVEL,
DEVEL,
DEVEL,
DEVEL,
DEVEL,
DEVEL,
DEVEL,
DEVEL,
DEVEL,
DEVEL,
DEVEL,
NEURO,
NEURO,
NEURO,
NEURO,
NEURO,
NEURO,
NEURO,
NEURO,
NEURO,
NEURO,
NEURO,
REPRO
REPRO
REPRO
REPRO
REPRO
REPRO
REPRO
REPRO
REPRO
REPRO
REPRO
CHR
CHR
CHR
CHR
CHR
CHR
CHR
CHR
CHR
CHR
CHR
DEGR
DEGR
DEGR
DEGR
DEGR
DEGR
DEGR
DEGR
DEGR
DEGR
DEGR
33
-------
CAS No.
Chemical Name
1992 Master Testing List
Chemicals
Yr
Source Added Status
Heahh
Testing Ehdpoints
_ Environ •.:...
Fate
68937-41-7 Phosphate, bis(isopropylphenyl
phenyl
Aiyl Phosphate* (continued)
ITC/ 2 92 F/93 DEVEL, NEURO, REPRO
Gfyckfol & Derivatives1
CHR
DEGR
101-90-6 Resorcinol diglycidyl ether
106-90-1 Glycidyl acrylate
106-91-2 Glycidyl methacrylate
106-92-3 Ally I glycidyl ether
122-60-1 Phenyl glycidy! ether
126-80-7 1,3-Bis[3-(2,3-epoxypropoxy|-
propylltetramethyldisiloxane
556-52-5 Glycidol
930-37-0 Methyl glycidyl ether
1675-54-3 Bisphenol A diglycidyl ether
2210-79-9 Cresyl glycidyl ether, o-
2224-15-9 Ethylene glycol diglycidyl ether
2238-07-5 Diglycidyl ether
ITC/ 3
ITC/ 3
ITC/ 3
ITC/ 3
ITC/ 3
ITC/ 3
ITC/ 3
ITC/ 3
ITC/ 3
ITC/ 3
ITC/ 3
ITC/ 3
92
92
92
92
92
92
92
92
92
92
92
92
F/94
F/94
F/94
F/94
F/94
F/94
F/94
F/94
F/94
F/94
F/94
F/94
CARC, MUTA, SCHR
DEVEL, MUTA, SCHR
DEVEL, MUTA. NEURO,
REPRO, SCHR
NEURO, REPRO
MUTA, NEURO, REPRO
CARC, DEVEL, MUTA, NEURO,
REPRO, SCHR
DEVEL, MUTA, NEURO, SCHR
34
-------
CAS No.
2425-01-6
2425-79-8
2426-08-6
2461-15-6
2461-18-9
2530-83-8
2897-60-1
3072-84-2
3101-60-8
3188-83-8
3568-29-4
4016-11-9
4016-14-2
5026-74-4
Chemical Name
Hydroquinone diglycidyl ether
Butanediol diglycidyl ether, 1,4-
Butyl glycidyl ether, n-
Ethylhexyl glycidyl ether, 2-
Lauryl glycidyl ether
Glycidoxypropyltrimethyoxysilane,
gamma-
3-(Methyldiethoxysilyl)propyl
glycidyl ether
Tetrabromobisphenol A diglycidyl
ether, 2,2',6,6'-
Butylphenyl glycidyl ether, p-tert-
2-Methylol-4,4'-isopropylidene-
diphenol diglycidyl ether
Glycerol 1,3-diglycidyl ether
Ethyl glycidyl ether
Isopropyl glycidyl ether
4-(Diglycidylamino)phenyl glycidyl
ether
1992 Master Testing List
Chemicals
Yr
Testing Endpoints
Source
GtycMol
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
Added
.11 u jt fcy»iiijii
ana iwira
92
92
92
92
92
92
92
92
92
92
92
92
92
92
Status Health Environ Fate
1
F/94
F/94 MUTA, NEURO, SCHR
F/94 CARC, DEVEL, MUTA,
NEURO, REPRO, SCHR
F/94 CARC, MUTA, SCHR
F/94
F/94 CARC, DEVEL, MUTA,
NEURO, REPRO, SCHR
F/94
F/94
F/94 i
F/94
F/94
F/94
F/94
F/94 MUTA
35
-------
CAS No.
5255-75-4
5493-45-8
6178-32-1
7195-45-1
7328-97-4
7422-52-8
7665-72-7
13236-02-7
13561-08-5
14228-73-0
15965-99-8
16245-97-9
17557-23-2
17963-04-1
Chemical Name
Nitrophenyl glycidyl ether, p-
Diglycidyt ester of hexahydro-
phthalic acid
p-Nonylphenyl glycidyl ether
Diglycidyl ester of phthalic acid
1,1,2,2-Tetra(p-hydroxyphenyl)-
ethane tetraglycidyl ether
3-[Bis(trimethylsiloxy)methyl)-
propyl glycidyl ether
Butyl glycidyl ether, tert-
Glycerol triglycidyl ether
Diglycidylphenyl glycidyl ether, 2,6-
Bis (glycidy loxy methyl)
cyclohexane, 1,4-
Hexadecyl glycidyl ether
Octadecyl glycidyl ether, n-
Neopentyl glycol diglycidyl ether
3-(Dimethylethoxysilyl)propyl
glycidyl ether
1992 Master Testing List
Chemicals
Yr
Source Added Status
Heatth
Testing Endpoints
Environ
Fate
GlyckJol
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/ 3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
I
& Derivatives, continued
92
92
92
92
92
92
92
92
92
92
92
92
92
92
F/94
F/94 CARC, MUTA, SCHR
F/94
F/94
F/94
F/94
F/94 SCHR
F/94
F/94
F/94
F/94
F/94
F/94 CARC, SCHR
F/94
36
-------
CAS No.
20217-01-0
22421-59-6
26447-14-3
26761-45-5
32568-89-1
35243-89-1
38304-52-8
38954-75-5
54208-63-8
60501-41-9
61578-04-9
67786-03-2
68081-84-5
68134-06-5
Chemical Name
Dibromophenyl glycidyl ether, 2,4-
Dibromo-4-methylphenyl glycidyl
ether, 2,6-
Cresyl glycidyl ether (mixed
isomers)
Glycidyl ester of neodecanoic acid
3-(2-Glycidyloxypropyl)-1-glycidol-
5,5-dimethylhydantoin
Oibromopropyl glycidyl ether, 1,2-
1,3-Bis(5,5-dimethyl-1 -glycidyl-
hydantoin-3-yl)-2-glycidyloxypropane
Tetradecyl glycidyl ether
Bisphenol F diglycidyl ether
Oleyl glycidyl ether
Cumylphenyl glycidyl ether, p-
[Bis(4-glycidyloxyphenyl)]-(2-
glycidyl-oxyphenyOmethane
Alkyl (Ci0-C16) glycidyl ether
Dimethylbutyl glycidyl ether, 1,3-
1992 Master Testing List
Chemicals
Yr
Source Added Status
Health
1 Testing End points
Environ
Fate
GtycttolS
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
iDerival
92
92
92
92
92
92
92
92
92
92
92
92
92
92
iv6s* Continued
F/94
F/94
F/94
F/94 DEVEL, MUTA, NEURO, SCHR
F/94
F/94
F/94
F/94
F/94
F/94
F/94
F/94
F/94 SCHR
F/94
37
-------
1992 Master Testing List
Chemicals
CAS No.
68134-07-6
68517-O2-2
68609-96-1
68609-97-2
68959-23-9
68987-80-4
69155-42-6
71033-08-4
71808-64-5
72319-24-5
74398-71-3
75150-13-9
Chemical Name
Methylheptyl glycidyl ether, 6-
Tris(4-hydroxyphenyl)propane-
triglycidyl ether
Alky I (C8-C10) glycidyl ether
Alkyl (C12-Ci4.) glycidyl ether
Hexanetriol triglycidyl ether,
1,2,6-
Alkyl (C6-C12) fllycidyl ether
1,1,1,3,5,7,7.7-Octamethyl-3,5-
bis(6,7-epoxy-4-oxaheptyl) tetra siloxane
2,2-Bislp-2-glycidyloxy-3-
butoxypropyloxyl-phenyllpropane
Dimethoxysilane, (3-glycidoxy-
propylKS-chloropropyl)-
2,2'-l(1-Methylethylidene)bis[4.1-
phenyleneoxy-3,1 -propanedioxy-
1,2,3-Propanetriyl ester of 12-
(oxiranylmethoxy)-9-octadecanoic acid
2,4-Dibromo-6-methylphenyl
glycidyl ether
Source
Glycklol
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
ITC/3
Yr
Added
«t\* mm ir^ *'
Denvftt
92
92
92
92
92
92
92
92
92
92
92
• i esung enuponnB
Status , Health Envfron Fate
I
* _-lu_ -1. .. *• < _fc
wt&t Continuea
F/94
F/94
F/94 REPRO, SCHR
F/94 DEVEL, MUTA, NEURO, SCHR
F/94
F/94
F/94
F/94
F/94
F/94
F/94
ITC/3
92
F/94 DEVEL, MUTA, NEURO, SCHR
38
-------
CAS No.
37853-59-1
71-55-6
120-82-1
141-79-7
1309-64-4
95-54-5
Chemical Name
1163-19-5 Decabromodiphenyl ether
3194-55-6 Hexabromocyclododecane
32534-81-9 Pentabromodiphenyl ether
32536-52-0 Octabromodiphenyl ether
Ethane, 1,2-bis{2,4.6-
tribromophenoxyl-
Trichloroethane, 1,1,1-
Trichlorobenzene, 1,2,4-
Mesityl oxide
Antimony trioxide
Phenylenediamine, ortho-
1992 Master Testing List
Chemicals
Yf
Source Added Status
Heahh
Testing Endpotnts
Environ
Fate
Bfunrinated name Retmianta
ITC/25 90 F/93
ITC/25 90 F/93
ITC/25 90 F/93
ITC/25 90 F/93
ITC/25 90 F/93
Other fTC Chemicals
ITC/2 90 T/92 .
ITC/3 90 T/94
ITC/ 4 90 T/92
ITC/4 90 T/93
ITC/ 6 90 T/92
CHR, DEVEL, MUTA,
NEURO, REPRO
CARC, CHR, DEVEL, MUTA,
NEURO, REPRO
CARC, CHR, DEVEL, MUTA,
NEURO, REPRO
CARC, CHR, DEVEL, MUTA,
NEURO, REPRO
CARC, CHR, DEVEL, MUTA,
NEURO, REPRO
DNEURO, NEURO, MUTA
CARC
SIDS
EPID
NEURO
]
ACUTE, CHR, BIOC, DEGR,
OTHR MONIT, PCHM,
TSPT
ACUTE, CHR, BIOC, DEGR,
OTHR PCHM, TSPT
ACUTE, CHR, BIOC, DEGR,
OTHR MONIT, PCHM,
TSPT
ACUTE, CHR, BIOC, DEGR,
OTHR MONIT, PCHM,
TSPT
ACUTE, CHR, BIOC, DEGR,
OTHR MONIT, PCHM,
TSPT
ACUTE, CHR TSPT
39
-------
1992 Master Testing List
Chemicals
CAS No.
106-50-3
108-45-2
75-02-5
75-38-7
1000-82-4
9011-05-6
68611-64-3
97380-66-3
None
110-82-7
126-73-8
128-39-2
96-29-7
67-63-0
CnoflMCfll Mains
Phenylenediamine, para-
Phenylenediamine, meta-
Vinyl fluoride
Vinylidene fluoride
Methylolurea
Urea-formaldehyde resins/
formaldehyde
Urea-formaldehyde resins
Urea-formaldehyde resins
Commercial Hexane
Cyclohexane
Tributyl phosphate
Di-tert-butylphenol
Methyl ethyl ketoxime
Isopropanol
Source
OttwrT
ITC/6
ITC/6
ITC/7
ITC/7
ITC/12
ITC/12
ITC/1 2
ITC/12
ITC/1 6
ITC/1 7
ITC/1 8
ITC/1 8
ITC/1 9
Yr
Added
M* fHijmmAn
1 \? ^fWlllH*
90
90
90
90
90
90
90
90
90
90
90
90
90
Status
mtm jJL.iii.rtim
art iconunu
T/92
T/92
T/93
T/93
A/93
A/93
A/93
A/93
T/93
F/94
T/94
T/93
T/94
, lesnng enaponrcs
Health Environ Fate
I
Ml)
NEURO ACUTE, CHR TSPT
NEURO, MUTA ACUTE, CHR TSPT
CARC, MUTA
CARC, MUTA, REPRO
ACUTE, SCHR MONIT
ACUTE, SCHR MONIT
ACUTE, SCHR MONIT
ACUTE, SCHR MONIT
CARC, DEVEL, MUTA,
NEURO, PK, REPRO, SCHR
ACUTE, CARC, DEVEL, MUTA
NEURO, PK, REPRO, SCHR
CARC, DEVEL, MUTA, ; ACUTE, CHR PCHM, TSPT
NEURO, OTHR, PK, REPRO
ACUTE, CHR DEGR, TSPT
CARC, NEURO, DEVEL
REPRO, MUTA
ITC/20 90 T/94 CARC, MUTA, SCHR, PK,
DEVEL, REPRO, NEURO
40
-------
1992 Master Testing List
Chemicals
SNo.
1634-04-4
822-06-0
4170-30-3
115-96-8
79-10-7
98-86-2
100-40-3
108-95-2
121-69-7
141-78-6
143-33-9
576-26-1
Chemical Nairn
Methyl tert-butyl ether
Hexamethylene diisocyanate, 1,6-
Crotonaldehyde
Tris(2-chloroethyl)phosphate
Acrylic acid
Acetophenone
Vinylcyclohexene, 4-
Phenol
Dimethylaniline, N,N-
Ethyl acetate
Sodium cyanide
Dimethylphenol, 2,6-
Source
Othw
ITC/20
ITC/22
ITC/22
ITC/23
ITC/27
ITC/27
ITC/27
ITC/27
ITC/27
ITC/27
ITC/27
ITC/27
Yr
Added
ITC ciwnifc
90
90
90
90
92
92
92
92
92
92
92
92
Status
en iconanu
T/92
F/93
T/92
F/93
T/94
S/93
T/94
S/93
S/93
S/93
T/94
S/93
lesung tnopotms
Health Environ Fata
I
Ml}
CARC, MUTA, NEURO,
DEVEL, REPRO
CARC, DEVEL, MUTA, PCHM
NEURO, PK, REPRO
CHR
SIDS
DEVEL, PK, REPRO
DEVEL, MUTA, NEURO, PK,
REPRO, SCHR
MUTA, PK, SCHR TSPT
NEURO, PK, REPRO, SCHR
DEVEL, MUTA, NEURO, PK, ACUTE, CHR DEGR
REPRO, SCHR
DEVEL, MUTA, NEURO,
REPRO, CARC
ACUTE, CHR TSPT
DEVEL, MUTA ACUTE, CHR DEGR, TSPT
NEURO, REPRO
41
-------
CAS No.
Chemical Nairn
1992 Master Testing List
Chemicals
Sourca
Yr
Added Status
Heahh
Testing Endpohits
_ Environ
Fate
Other ITC Chemicals (continued)
67-64-1 Acetone
71-36-3 Butanol, 1-
78-83-1 Isobutyl alcohol
103-23-1 Di(2-ethylhexyl) adipate
108-98-5 Thiophenol
120-61-6 Dimethyl terephthalate
75-35-4 Dichloroethylene, 1,1-
ITC/28
ITC/28
ITC/28
ITC/28
ITC/28
92
92
92
92
92
S/93
S/93
S/93
S/93
S/93
ITC/28
92
S/93
Office of Air and Radiation
OAR
90
S/94
REPRO
REPRO
CARC, DEVEL, PK, REPRO
DEVEL, NEURO, REPRO
CARC, DEVEL, MUTA,
NEURO, PK, REPRO
DEVEL, NEURO, REPRO
CARC, PK
CHR
ACUTE.CHR
ACUTE, CHR
DEGR, PCHM
DEGR, TSPT
PCHM
DEGR
Office of Pollution Prevention and Toxics
50-00-0
84852-15-3
142844-00-6
Formaldehyde
Nonylphenol
Refractory Ceramic Fibers
OPPT
OPPT
OPPT
92
92
92
A/93
T/93
T/92
Emissions Characterization
Exposure Characterization
CHR, ACUTE
PCHM, BIOC
42
-------
CAS No.
57-10-3
74-97-5
75-15-0
79-31-2
95-80-7
100-21-0
104-76-7
107-13-1
111-11-5
120-80-9
123-30-8
27193-86-8
Chemical Name
Hexadecanoic acid
Bromochloromethane
Carbon disulfide
Methylpropanoic acid, 2-
Diaminotoluene, 2,4-
Terephthalic acid
Ethylhexanol, 2-
Acrylonitrile
Octanoic acid, methyl ester
Hydroxyphenol, o-
Aminophenol, p-
Dodecylphenol
60-29-7 Diethyl ether
67-64-1 Acetone
71-36-3 Butanol, 1-
1992 Master Testing List
Chemicals
Yr
Source Added Status
Health
= Testing Endpoints
Environ
Fate
I
eVeJopmental and Reproductive Effects
OPPT/D
OPPT/D
OPPT/D
OPPT/D
OPPT/D
OPPT/D
OPPT/D
OPPT/D
OPPT/D
OPPT/D
OPPT/D
OPPT/D
91
91
91
91
91
91
91
91
91
91
91
91
Neurotoxfccfogic
OPPT/N
OPPT/N
OPPT/N
91
91
91
F/93
F/92
F/93
F/93
F/93
F/93
F/93
F/93
F/93
F/93
F/93
F/93
Effects
F/93
F/93
F/93
DEVEL
REPRO
REPRO
DEVEL
DEVEL, REPRO
REPRO
DEVEL
DEVEL
DEVEL
DEVEL
DEVEL
DEVEL
NEURO
NEURO
NEURO
43
-------
CAS No.
78-83-1
108-10-1
109-99-9
110-80-5
123-86-4
141-78-6
628-63-7
79-94-7
87-10-5
118-75-2
118-79-6
1163-19-5
4162-45-2
25327-89-3
32534-81-9
Chemical Name
Isobutyl alcohol
Methyl isobutyl ketone
Tetrahydrofuran
Ethoxyethanol, 2-
Butyl acetate, n-
Ethyl acetate
Amyl acetate, n-
Tetrabromobisphenol-A
Tribromosalicylanilide, 3,4'5-
Chloranil
2,4,6-Tribromophenol
Decabromodiphenyloxide
Tetrabromobisphenol-A-bis(ethoxyla
Tetrabromobisphenol-A, ally! ether
Pentabromodiphenylether
1992 Master Testing List
Chemicals
Yr
Source Added Status
Health
; Testing Endpotnts
Environ
Fate
Neurotoxicotogic Effect* (contimied)
OPPT/N 91
OPPT/N 91
OPPT/N 91
OPPT/N 91
OPPT/N 91
OPPT/N 91
OPPT/N 91
F/93 NEURO
F/93 NEURO
F/93 NEURO
F/93 NEURO
F/93 NEURO
F/93 NEURO
F/93 NEURO
Pofyhalogenated Dibenzo-p-Dk>xins/Dibenzofurans*
OPPT/DF 90
OPPT/DF 90
OPPT/DF 90
OPPT/DF 90
OPPT/DF 90
OPPT/DF 90
OPPT/DF 90
OPPT/DF 90
T/93
T/95
T/93
T/93
T/92
T/93
T/93
T/93
OTHER
OTHER
OTHER
OTHER
OTHER
OTHER
OTHER
OTHER
44
-------
CAS No.
32536-52-0
37853-59-1
74-87-3
75-00-3
75-34-3
75-69-4
79-00-5
79-34-5
103-65-1
108-67-8
Chemical Name
Octabromodiphenyloxide
Bis(tribromophenoxy)-ethane, 1,2-
Chloromethane
Chloroethane
Dichloroethane, 1,1-
Fluorotrichloromethane
Trichloroethane, 1,1,2-
Tetrachloroethane, 1,1,2,2-
Propylbenzene, n-
Trimethylbenzene, 1,3,5-
1992 Master Testing List
Chemicals
Yr
Source Added Status
Health
Testing Endpoints
Environ
Fate
I—.* flifet^n-,
tea uiDeru
OPPT/DF
OPPT/DF
OW
OW
OW
OW
OW
OW
OW
OW
•Jv dmi Itifhw^i
CO*p-vlH}XM1
90
90
Office of
90
90
90
90
90
90
90
90
!
a/Dibciuururuii6 (contnued)
T/92 OTHER
T/95 OTHER
Water
F/93 PCHR, SCHR
F/93 PCHR, SCHR
F/93 PCHR, SCHR
F/93 PCHR, SCHR
F/93 PCHR, SCHR
F/93 PCHR, SCHR
F/93 PCHR, SCHR
F/93 PCHR, SCHR
45
-------
1992 Master Testing List
Organization for Economic Cooperation and Development (OECDJ^
Screening Information Data Set
CAS No.
Chemicaf Name
Ctry/Phase
NOTE: As of November 1992, testing is underway or completed for the chemicals in
Phase I; the chemicals in Phases 2 and 3 are scheduled for initiation of testing
in 1993.
OECD PHASE 1
59-67-6 Nicotlnic acid
70-55-3 Benzenesulfonamlde, 4-methyl-
75-54-7 Silane. dichloromethyl-
75-77-4 Silane, chlorotrimethyl-
75-78-5 Silane, dichlorodimethyl-
75-79-6 Silane, trichloromethyl-
75-91-2 Hydroperoxlde, 1,1-dimethylethyl-
77-99-6 Propanediol, 2-ethyl-2-(hydroxymethyl)-, 1,3-
78-40-0 Triethyl phosphate
78-84-2 Propanal, 2-methyl-
79-92-5 Camphene
88-72-2 Nitrotoluene, 2-
99-09-2 Nitroaniline, 3-
107-01-7 Butene, 2-
112-53-8 Oodecanol, 1-
112-92-5 Octadecanol, 1-
123-38-6 Propanal
126-30-7 Propanediol, 2,2-dimethyl-, 1,3-
126-58-9 Propanediol, 2.2'-[oxybis-(methylene)]-
bls [2-(hydroxymethyl
128-39-2 Di-tert-butylphenol
147-14-8 C.I. Pigment Blue 15
Yr
Added
CH/1
JP/1
FR/1
US/1
FR/1
FR/1
NL/1
JP/1
DE/1
US/1
DE/1
SE/1
JP/1
NL/1
DK/1
DK/1
US/1
JP/1
SE/1
CH/1
JP/1
90
90
90
90
90
90
90
90
92
90
92
90
90
90
90
90
90
90
90
90
90
46
-------
CAS No.
156-43-4
294-62-2
504-60-9
536-90-3
556-67-2
584-03-2
693-23-2
1758-73-2
2402-79-1
2431-50-7
3209-22-1
6386-38-5
6419-19-8
25265-77-4
29171-20-8
29590-42-9
37971-36-1
57-13-6
74-85-1
75-86-5
76-03-9
78-93-3
78-97-7
79-11-8
1992 Master Testing List
Organization for Economic Cooperation and Development (OECD)
Screening Information Data Set
Chemical Name
Benzenamine, 4-ethoxy-
Cyclododecane
Pentadiene, 1,3-
Benzenamine, 3-methoxy-
Octamethylcydotetrasiloxane
Butanediol, 1.2-
Dodecanadioic add
Methanesulfmic add, amlnolmlno-
Tetrachloropyridine, 2,3,5,6-
2,3,4-trichlorobut-1 -ene
Benzene, 1,2-dichloro-3-nitro-
Benzenepropanoic add, 3,5-bls(1,1-di-
methylethyl)-4-hydroxy
Phosphoric add, [Nitrilotris-(methylene)]tris-
Propanolc add, 2-methyl-, monoester
6-Octen-1-yn-3-ol, 3.7-dimethyl-
Propenoic add, isooctyl ester, 2-
Butanetricarboxylic add, 1,2.4-
OECD PHASE 2
Urea
Ethylene
Acetone cyanhydrin
Trldiloroacetic add
Methyl ethyl ketone
Propanentolle, 2-hydroxy-
Chloroacetic add
y/Phase
jp/1
FR/1
US/1
JP/1
US/1
JP/1
US/1 .
AT/1
US/1
DE/1
JP/1
CH/1
UK/1
US/1
CH/1
US/1
DE/1
FI/2
NO/2
UK/2
DE/2
US/2
JP/2
SE/2
Yr
Added
90
90
90
90
90
90
90
90
90
90
90
90
90
90
90
90
90
92
92
92
92
92
92
92
47
-------
1992 Master Testing List
, ' Organization for Economic Cooperation and Development (OECD)
Screening information Data Set
CAS No. Chemical Name
80-43-3 Dicumyl peroxide
95-48-7 o-Cresol
95-73-8 2,4-DicMorotokiene
97-65-4 Butanediolc add, methylene-
98-56-6 Benzene, 1-diloro-4-(trifluoromethyl)-
100-21-0 Terephthalic add
104-94-9 Aniline, 4-methoxy-
105-05-5 Benzene, 1,4-diethyl-
105-76-0 Maleic add, dibutyl ester
106-98-9 Butene-1
107-21-1 Ethylene gJycol
107-66-4 Phosphoric add, dibutyl ester
108-01-0 Dimethylaminoethanol
108-10-1 Methyl isobutyl ketone
108-24-7 Acetic anhydride
108-78-1 Melamine
108-83-8 Heptanone, 2.6-dimethyl-, 4-
108-99-6 Pyridine, 3-methyl-
109-55-7 1 -Amlno-3-dimethylamIno propane
109-69-3 Chlorobutane, 1-
111 -40-0 Diethylenetriamine
111 -42-2 Dtethanolamine
111-66-0 1-Octane
112-18-5 N,N-Dimethyldodecylamine
112-41-4 1-Dodecene
115-18-4 3-Buten-2-ol, 2-methyl-
y/Phase
BE/2
FR/2 US/2
JP/2
FR/2
IT/2 US/2
IT/2
DE/2
JP/2
AT/2
CA/2
CA/2
JP/2
UK/2
US/2
CA/2
AT/2
FR/2
BE/2
DE/2
JP/2
NL/2
UK/2
US/2
DE/2
US/2
CH/2
Yr
Added
92
92
92
92
92
92
92
92
90
92
92
92
92
92
92
92
90
90
92
92
92
92
92
92
92
92
48
-------
1992 Master Testing List
Organization for Economic Cooperation and Development {OEGDJ
Screening Information Data Set
CAS No. Chemical Name
115-19-5 3-Butyn-2-ol, 2-methyl-
120-61-6 Dimethyl terephthalate
121-14-2 -Benzene. 1
-------
CAS No.
iiWii
28629-66-5 Phosphorodithioic add, 0,O-diisooctyl
OECDPHASE3
50-81-7 L-Ascorbic add
75-98-9 2,2-dimethyl-propanoic add
79-94-7 Tetrabromobisphenol A
80-05-7 Bisphenol A
81-11-8 Benzenesulfonlc add, 2,2'-(1,2-ethenedi-
82-45-1 1-Aminoanthraquinone
89-61-2 Benzene, 1,4-dichloro-2-nitro-
92-70-6 2-Hydroxy-3-naphthoic add
100-52-7 Benzaldehyde
101-54-2 1,4-Benzenediamine, N-phenyl-
101-68-8 Methylenediphenyl dHsocyanate.4,4'-
101-72-4 Benzenediamine. N-(1-methylethyl)-N'-phenyl-, 1,4-
102-01-2 Acetoacetanilide
102-71-6 Triethanolamlne
104-76-7 Ethylhexanol, 2-
104-90-5 2-Picoline, 5-ethyl-ethoxy]-
105-99-7 Di-butyl adipate
106-42-3 p-Xylene
107-22-2 Glyoxal
107-64-2 1-Octadecanamlnium, N,N-dimethyl-N-octad
108-44-1 m-Toluldine
108-89-4 Pyridine. 4-methyl-
108-94-1 Cydohexanone
US/2
Addeo
92
UK/3
NL/3
US/3
CH/3
JP/3
JP/3
JP/3
DE/3
NU3
DE/3
US/3
UK/3
US/3
UK/3
SE/3 US/3
CH/3
JP/3
IT/3
FR/3
DE/3
JP/3
BE/3
CA/3
92
92
92
92
92
92
92
92
92
92
92
90
92
92
92
92
92
92
92
92
92
90
92
50
-------
1992 Master Testing List
*v •.•.*•
Organization for Economic Cooperation and Development (OECD)
Screening Information Data Set
CAS No* Chemical Name
109-06-8 Pyrldine, 2-methyl-
110-27-0 Isopropyl myrlstate
110-30-5 OctadecanamMe,N,N'-1^2-ethanediylbis-
110-91-8 Morpholine
111 -46-6 Diathylane glycol
111-69-3 1,4-Dicyanobutane
112-24-3 Triethylene tatramine
112-35-6 Ethanol, 2-[2-(2-mathoxy-athoxy)
1T2-50-5 Triethylene glycol. monoethyl ether
112-72-1 1 -Tetradecanol
112-90-3 9-Octadecen-1-amine. (Z\-
115-11-7 2-Methylpropene
116-15-4 Hexafluoropropene
118-69-4 2.6-Dlchlorotoluene
120-78-5 Benzthlazole disulflde
121-33-5 Vanillin
123-01 -3 Dodecylbenzene
123-31-9 Hydroquinone
123-72-8 Butyraldehyde
123-77-3 Diazenedicarfaoxamlde
127-19-5 Dimethylacetamide
135-19-3 2-Napththol
140-66-9 Phenol, 4-(1.1,3,3-tetramethylbirtyl)-
141-79-7 Mesrtyl oxide
512-56-1 Phosphoric add, trimethyl ester
611 -06-3 Benzene, 2,4-dichloro-l -nitro-
ry/Phase 4
BE/3 •"' ••-"'.:•• ' •
DE/3
US/3
UK/3
CA/3
FR/3
DE/3
US/3
US/3
US/3
US/3
FR/3
IT/3US/3
JP/3
DE/3
NO/3
US/3
US/3
US/3
DE/3
IT/3
DE/3
CH/3
US/3
JP/3
JP/3
Yr
Added
90
92
92
92
92
92
92
92
92
92
92
92
90
92
92
92
92
92
92
92
92
92
92
92
92
92
51
-------
1992 Master Testing List
Organization for Economic Cooperation and Development (OECDJ
Screening Information Data Set
CAS No. Chemical Name
-' 623-91-6 . 2-Butenediolc add (E)-. diethyl ester
629-11-8 Hexamethylene glycol
,872-05-9- Deoene, n-
1163-19-5 Decabromodiphenyl ether
1854-26-8 2-lmldazolldinone, 4.5-dihydroxy-1,3-bis
1879-09-0 6-tart-butyl-2,4-xylenol
2524-03-0 Dimethyl chlorothiophosphate
2524-04-1 Diethyl chlorothiophosphate
, ,-• 4979-32-2 N,N-dicydohexyl-2-benzothlazolesulfenam
!.:,- 5392-40-5 Cltral
;: 6742-54-7 Benzene, undecyl
13674-84-5 2-propanol,1-chloro-. phosphate (3:1)
Ctry/Phase
Yr
Added
JP/3
DE/3
FI/3
US/3
DE/3
JP/3
US/3
US/3
JP/3
JP/3
US/3
US/3
92
92
90
90
92
92
92
92
92
92
92
92
52
-------
1992 Master Testing List
ENDNOTES
J, r>
1. "Glycidol and its derivatives" is a category comprised of
66 specific chemicals. To understand the proposed testing
requirements for this category, refer to "Glycidol and its
Derivatives Category; Proposed Test Rule with Reporting and
Recordkeeping Requirements" (56 FR 57144; November 7, 1991).
Chemical testing end points, which are the subject of, the
proposal, are shown on the MTL. EPA will evaluate public
comments on the proposal and determine the further testing that
is necessary for the members of this category.
2. A test rule entitled "Polyhalogenated Dibenzo-p-
Dioxins/Dibenzofurans; Testing and Reporting Requirements;*" Final
Rule" (52 FR 21412, June 5, 1987) requires analytical testing for
dioxin/furan contamination of the chemicals listed under this
source.
3. Based on the OECD "Working List of Priority Chemicals",
October 19, 1992.
53
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