United States           Office of Prevention. Pesticides EPA 738-S-93-001
         Environmental Protection      and Toxic Substances     February 1993
         Agency             (H-7508W)            '	

&EPA  Reregistration

         Eligibility Document

         (RED)
          Iron Salts
                                      Recycled/Recyclable
                                      Printed on paper that contains
                                      at least 50% recycled fiber

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                  United States
                  Environmental Protection
                  Agency
Office of Prevention, Pesticides
And Toxic Substances
(H-7508W)
EPA-738-F-93-002
February 1993
                  R.E.D.    FACTS
                  Iron  Salts
      Pesticide       All pesticides sold or used in the United States must be registered by
Reregistration   EPA, based on scientific studies showing that they can be used without
                  posing unreasonable risks to people or the environment. Because of
                  advances in scientific knowledge, the law requires that pesticides which
                  were first registered years ago be reregistered to ensure that they meet
                  today's more stringent standards.
                      In evaluating pesticides for registration, EPA obtains and reviews a
                  complete set of studies from pesticide producers, describing the human
                  health and environmental effects of each pesticide. The Agency imposes
                  any regulatory controls that are needed to effectively manage each
                  pesticide's risks. EPA then reregisters pesticides that can be used without
                  posing undue hazards to human health or the environment.
                      When a pesticide is eligible for reregistration, EPA announces this
                  and explains why in a Reregistration Eligibility Document, or RED. This
                  fact sheet summarizes the information in the RED for iron salts.
   Use Profile       The iron salts consist of three pesticide active ingredients that are
                 eligible for reregistration:  Iron (HI) sulfate, Iron (n) sulfate monohydrate,
                 and Iron (II) sulfate heptahydrate.
                      Iron salts are registered for use as herbicides to control moss on
                 lawns, turf,  ornamental herbaceous plants, woody shrubs and vines.
                 Registered products are formulated as soluble concentrates and granulars.
                 They are applied by sprinkler can, hose-end sprayer, spreader, or by hand.
                      The major use of iron salts in the United States is non-pesticidal, as a
                 fertilizer micronutrient.  Iron salts also are used as an electrolyte in dry
                 cell batteries, as an animal feed additive, as a galvanizer and as an
                 emulsion-breaker. They have further uses in water purification and sewage
                 treatment, and in textile dying and calico printing.


   Regulatory       Iron salts first were registered as pesticides in 1962.  In addition to
       History  *e current outdoor moss control uses, iron salts were registered previously
                 for use inside households, and in and around commercial, institutional and
                 industrial premises.
                      At present,  a total of 13  products are registered containing iron salts
                 as sole or one of several active ingredients; one product contains Iron (ffl)

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                    sulfate, nine contain Iron (n) sulfate monohydrate, and three contain Iron
                    (n) sulfate heptahydrate.
                         A fourth active ingredient, Iron n ammonium sulfate, is not being
                    supported for reregistration and so is not covered in this RED.
Human  Health   Toxicity
   Assessment
      Iron salts are present normally in the environment.  Iron is the fourth
most abundant element and the second most abundant metal in the earth's
crystal rocks.  Iron occurs in a wide variety of minerals, and is present in
foods naturally and through added ingredients.
      The iron salts are of low acute toxicity through oral, dermal and
inhalation routes of exposure.  They have been placed in Toxicity Category
m for these effects. Although a mutagenicity study using microorganisms
showed positive results, it is unlikely that such effects would result in
humans or other mammals at the levels of exposure expected from the use
of iron salts as pesticides. Other toxicity studies normally required for
reregistration were not necessary to evaluate the risks of the iron salts.
Dietary Exposure
      Dietary exposure is not expected to result from use of the iron salts
as pesticides.  No food or feed-related uses are registered, and no
tolerances (maximum residue limits) or exemptions from the requirement
of a tolerance are established.  Further, the iron salts are generally
recognized as safe (GRAS) by  the Food and Drug Administration for use
as a flavoring agent and nutrient supplement in foods (please see 40 CFR
180.2(a)).
Occupational and Residential Exposure
      The potential for mixer, loader and applicator exposure exists when
liquid or granular iron salts products are applied to lawns, turf and other
outdoor sites using spreaders, sprinkler cans or by hand.  However, these
inorganic salts  are of little concern from a toxicity perspective. Any
exposure of mixers, loaders or applicators is considered inconsequential.
Human Risk Assessment
     The risks to people from dietary, occupational and residential
exposure to iron salts  pesticides are considered negligible.  It is general
knowledge that these compounds are of low toxicity.  They are
intentionally added to foods as flavoring agents and nutrient supplements,
and they have an inherent function in the metabolic systems of humans and
domestic animals.
Environmental   Environmental Fate
  Assessment        The environmental fate and transport of iron salts is dominated by
                   three processes:  the conversion of Iron (II) to Iron (IE), the formation of

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                        insoluble oxides and hydroxides that also are well known components of
                        soils, and the distinct surface chemistry of the iron salts that causes their
                        adsorption with other soil components, forming larger soil particles.
                              Use of the iron salts produces iron oxides and hydroxides that are no
                        different from those normally found in soils, and which give them their
                        brown and red colors.  Although certain bacteria can reduce Iron (ffl) to
                        the more mobile Iron (II), this is rapidly immobilized.
                              Therefore, the use of iron salts as herbicides to control moss is not
                        expected to contribute significantly to the chemistry and fate of the
                        compounds existing naturally in the environment.  No unreasonable effects
                        are expected from the use of these pesticide products as directed.
                        Ecological Effects
                              In dietary acute toxicity studies, iron salts are practically nontoxic to
                        bird species and are nontoxic or slightly toxic to rats.  Iron (II) sulfate
                        heptahydrate,  the most toxic form of the iron salts compounds, is
                        moderately toxic to aquatic invertebrates and slightly toxic to fish.
                              No adverse effects to avian, mammalian or aquatic populations are
                        anticipated from the use of iron salts.  Iron is one of the earth's most
                        abundant elements, and it is immobilized at the  pH range of 5-9. Runoff
                        to aquatic systems is unlikely since the parent compounds convert very
                        rapidly to less soluble forms in the environment. Furthermore, the
                        oxidized iron  compounds bind tightly to soil under turf.
                              No adverse effects to endangered species are anticipated from the use
                        of iron salts.

   Additional Data         EPA is requiring additional physical chemistry studies as
           Required   confirmatory data and to complete the generic data base for iron salts.
                        Product-specific product chemistry studies and revised  labeling also are
                        required for reregistration.  These additional studies are being required
                        through Data  Call-Ins issued in conjunction with the iron salts RED.

  Product Labeling         The labels of all registered iron salts products must comply with
Changes Required   EPA's current pesticide labeling requirements.  In addition, to protect
                        surface waters, end-use product labels must bear the following
                        Environmental Hazards statement:
                              "Do not apply directly to water,  or to areas where surface water is
                              present or to intertidal areas below the mean high water mark.  Do
                              not contaminate water when disposing of equipment washwater or
                              rinsate."


         Regulatory           The  three pesticide active ingredients discussed in the iron salts
        Conclusion   RED wil1 not result ^ unreasonable adverse effects to human health or the
                        environment, and all registered products containing these active ingredients

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                are eligible for reregistration.  These products will be reregistered once the
                required generic and product-specific data and revised labeling are received
                and accepted by EPA.
                       Registered products containing iron salts as well as other active
                ingredients will be reregistered once the other active ingredients also are
                determined to be eligible for reregistration.

   For More        EPA is requesting public comments on the Reregistration Eligibility
Information   Document (RED) for iron salts during a 60-day time period, as announced
                in a Notice of Availability published in the Federal Register.  To obtain a
                copy  of the RED or to submit written comments, please contact the
                Pesticide Docket, Public Response and Program Resources Branch, Field
                Operations Division (H-7506C), Office of Pesticide Programs (OPP), US
                EPA, Washington, DC 20460, telephone 703-305-5805.
                     Following the comment period, the iron salts RED will be available
                from  the National Technical Information Service (NTIS), 5285 Port Royal
                Road, Springfield, VA 22161, telephone 703-487-4650.
                     For more information about iron salts or about EPA's pesticide
                reregistration program, please contact the Special Review and
                Reregistration Division (H-7508W), OPP,  US EPA, Washington, DC
                20460, telephone 703-308-8000.  For information about reregistration of
                individual iron salts products, please contact Joanne Miller, Product
                Manager, Registration Division (H-7505C), OPP, US EPA, Washington,
                DC 20460, telephone 703-305-7830.
                     For information about  the health  effects of pesticides, or for
                assistance in recognizing and managing pesticide poisoning symptoms,
                please contact the National Pesticides Telecommunications Network
                (NPTN).  Call toll-free 1-800-858-7378, between  8:00 am and 6:00 pm
                Central Time, Monday through Friday.

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REREGISTRATION ELIGIBILITY DOCUMENT

                IRON SALTS

                   LISTD

                  CASE 4058
        ENVIRONMENTAL PROTECTION AGENCY
          OFFICE OF PESTICIDE PROGRAMS
     SPECIAL REVIEW AND REREGISTRATION DIVISION
               WASHINGTON, D.C.

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IRON SALTS REREGISTRATION ELIGIBILITY TEAM

Office of Pesticide Programs:

Biological and Economic Analysis Division
Jim Saulmon                     Biological Analysis Branch
Ed Brandt                        Economic Analysis Branch
Steve Jaiboe                     Biological Analysis Branch

Environmental Fate and Effects Division
Conception Rodriguez             Ecological Effects Branch
Sylvia Termes                    Environmental Fate and Groundwater Branch
Mary Frankenberry               Science Analysis and Coordination Staff

Health Effects Division
Jane Smith                       Chemical Coordination Branch
Pat McLaughlin                  Toxicology Branch II
Judy Smith                       Occupational and Residential Exposure Branch

Registration Division
Shyem Mathur                    Registration Support Branch
Ian Blackwell                    Registration Support Branch
Jesse Mayes                     Fungicide-Herbicide Branch

Special Review and Reregistration Division
Barbara Briscoe                  Accelerated Reregistration Branch
Yvonne Brown                    Accelerated Reregistration Branch

Policy and Special Projects Staff
Jean Frane                       Food Safety & Regulator Tracking Section

Office of General Counsel
Alan Carpien

Office of Compliance Monitoring
Phyllis Flaherty                  FIFRA Policy  & Analysis Branch  Policy and  Grants
                                 Division

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                         TABLE OF CONTENTS


I.     EXECUTIVE SUMMARY  	   1

H.    INTRODUCTION	   2

m.   CASE OVERVIEW	   3
      A.    Chemical Overview	   3
      B.    Use Profile	   4
      C.    Regulatory History  	   6

IV.   SCIENCE ASSESSMENT OF IRON SALTS  	   6
      A.    Physical Chemistry  Assessment	   6
      B.    Human Health Assessment	   7
      C.    Environmental Assessment	   9

V.    RISK MANAGEMENT AND REREGISTRATION DECISION FOR IRON
      SALTS	14
      A.    Determination of Eligibility	14

VI.   ELIGIBILITY DECISION  	14
      A.    Eligible and Ineligible Uses	15

VH.  ACTIONS REQUIRED BY REGISTRANTS	15
      A.    Additional Generic Data Requirements  	15
      B.    Product specific data requirements	15
      C.    Labeling Requirements for Manufacturing-Use and End-Use Products  ...  15


VIII.  APPENDICES

      APPENDIX A - Use Patterns Subject to Reregistration

      APPENDIX B - Table of the Generic Data Requirements and Studies Used to Make the
      Reregistration Decision

      APPENDIX  C -  Citations Considered to be Part of the Data Base  Supporting the
      Reregistration of Iron Salts

      APPENDIX D - List of Available Related Documents

      APPENDIX E - Pesticide Reregistration Handbook

      APPENDIX F - Generic Data Call-In

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        Attachment A - Chemical Status Sheet
        Attachment B - Generic DCI Response Forms (Form A) plus Instructions
        Attachment C - Requirements Status and Registrants'  Response Forms (Form
                           B) plus Instructions
        Attachment D - List of all Registrant(s) sent this DCI
        Attachment E - Cost Share/Data Compensation Forms

APPENDIX G - Product Specific Data Call-In

        Attachment A - Chemical Status Sheet
        Attachment B - Product Specific DCI Response Forms (Form A) plus Instructions
        Attachment C - Requirements Status and Registrants'  Response Forms (Form
              B) plus Instructions
        Attachment D  -  EPA Grouping  of  End  Use Products for meeting Acute
              Toxicology Data Requirements.
        Attachment E - EPA  Acceptance Criteria
        Attachment F - List of all Registrant(s) sent this DCI
        Attachment G - Cost  Share/Data Compensation Forms
                                   11

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                  GLOSSARY OF TERMS AND ABBREVIATIONS

a.i.          Active Ingredient

CAS         Chemical Abstracts Service

CSF         Confidential Statement of Formula

EEC         Estimated Environmental Concentration.  The estimated pesticide concentration
             in an environment, such as a terrestrial ecosystem.

EP          End-Use Product

EPA         U.S. Environmental Protection Agency

FIFRA       Federal Insecticide, Fungicide, and Rodenticide Act

FFDCA      Federal Food, Drug, and Cosmetic Act

HDT        Highest Dose Tested

LC50         Median Lethal Concentration. A statistically derived concentration of a substance
             that can be  expected to cause death in 50% of test animals.   It is usually
             expressed as the weight of substance per weight or volume of water or feed, e.g.,
             mg/1 or ppm.

LD50         Median Lethal Dose.  A statistically derived single dose that can be expected to
             cause death in 50% of the test animals when administered by the route indicated
             (oral, dermal, inhalation).   It is expressed as a weight of substance per unit
             weight of animal, e.g., mg/kg.

Ld,o         Lethal Dose-low. Lowest Dose at which lethality occurs

LEL         Lowest Effect Level

MP         Manufacturing-Use Product

MRID       Master Record Identification (number). EPA's system of recording and tracking
             studies submitted.

N/A         Not Applicable

NPDES      National Pollutant Discharge Elimination System
                                         111

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GLOSSARY OF TERMS AND ABBREVIATIONS (cont.)



NOEL       No Observed Effect Level




OPP        Office of Pesticide Programs




ppm        Parts Per Million



TD         Toxic Dose. The dose at which a substance produces a toxic effect.



TC         Toxic Concentration. The dose at which a substance produces a toxic effect.
                                      IV

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I.     EXECUTIVE SUMMARY

       The active ingredients covered in this document include iron (III) sulfate, iron (II)
sulfate monohydrate and iron (II) sulfate heptahydrate in the chemical case iron salts.
Products containing these active ingredients are used as herbicides for the control of moss on
ornamental herbaceous plants, lawns, turf, wood shrubs and vines.  This Reregistration
Eligibility Document (RED) addresses the eligibility for reregistration of products containing
these active ingredients for the above mentioned use sites only.

       The U.S.  EPA  (hereafter referred to as "the Agency") has determined that the uses of
these three active ingredients, as they are currently registered, will not cause unreasonable
risk to humans or the environment.  Therefore, products containing the iron salts are eligible
for reregistration. The Agency is requiring additional studies on physical chemistry as
confirmatory data and  for purposes of labeling to complete the generic data base.

       Before reregistering the products containing these iron salts, the Agency is requiring
that product specific data and revised labeling be submitted within eight months of the
issuance of this document. These data include product chemistry and acute toxicity testing.
After reviewing these data and any  revised labels and finding them acceptable, the Agency
will reregister a product based  on whether or not that product meets the requirements in
Section 3(c)(5) of FIFRA.

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H.    INTRODUCTION

       In 1988, the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) was
amended to accelerate the reregistration of products with active ingredients registered prior to
November 1,  1984.  The amended Act provides a schedule for the reregistration process to
be completed  in nine years.  There are five phases to the reregistration process.  The first
four phases of the process  focus on identification of data requirements to support the
reregistration  of an active ingredient and the generation and submission of data to fulfill the
requirements.  The fifth phase is a review by the U.S. Environmental Protection Agency
(referred to as "the Agency") of all data submitted to support reregistration.

       FIFRA Section 4(g)(2)(A) states that in Phase 5 "the Administrator shall determine
whether pesticides containing such active ingredient are eligible for registration"  before
calling in data on products and either reregistering products or taking "other appropriate
regulatory action." Thus,  reregistration involves a thorough review of the scientific data
base underlying a pesticide's registration. The purpose of the Agency's review is to reassess
the potential hazards arising from the currently registered uses of the pesticide; to determine
the need for additional data on health and environmental  effects; and to determine whether
the pesticide meets the "no unreasonable adverse effects" criterion of FIFRA.

       This document presents the Agency's decision regarding the reregistration eligibility
of the registered  uses of iron (III) sulfate, iron (II) sulfate monohydrate, and iron (II) sulfate
heptahydrate.   The document consists of six sections. Section I is the introduction.  Section
II describes these iron salts, their uses, data requirements and regulatory history.  Section in
discusses the human health and environmental assessment based on the data available to the
Agency.  Section IV presents the reregistration decision for iron salts. Section V discusses
the reregistration requirements for iron salts.  Finally, Section VI is the Appendices which
support this Reregistration  Eligibility Document.  Additional details concerning the Agency's
review of applicable data are available on request.1
    1 EPA's reviews of data on the set of registered uses considered for EPA's analysis may be
requested from the Public Response and Program Resources Branch, Field Operations Division
(H7506C), Office of Pesticide Programs, EPA, Washington, DC 20460.

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CASE OVERVIEW


A.    Chemical Overview

The following active ingredients are covered by this Reregistration Eligibility
Document:

      1.    Chemical Name: Iron (III) sulfate

            o     CAS Registry Number:  10028-22-5

            o     Office of Pesticide Programs Chemical Code: 34902

            o     Empirical Formula:
      2.    Chemical Name: Iron (II) sulfate monohydrate

            o     CAS Registry Number: 17375-41-6

            o     Office of Pesticide Programs Chemical Code: 50507

            o     Empirical Formula: FeSO4H2O


      3.    Chemical Name: Iron (II) sulfate heptahydrate

            o     CAS Registry Number: 7782-63-0

            o     Office of Pesticide Programs Chemical Code: 50502

            o     Empirical Formula: FeSO4-7H2O

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B.     Use Profile

       The following is information on the current registered uses with an overview
of use sites and application methods. A detailed table of these uses of iron (HI)
sulfate, iron (II) sulfate monohydrate and iron (n) sulfate heptahydrate is in Appendix
A.

       1.    For Iron (HI) sulfate:

       Type of Pesticide:  Herbicide

       Use Sites:           Ornamental lawns and turfterrestrial non-food, outdoor
                           residential

       Target Pest:         Mosses

       Formulation Types Registered:
                           Soluble concentrate/liquid

       Method and  Rates
       of Application:      Equipment - Sprinkler can and hose-end sprayer.
                           Method and Rate - Soluble concentrate/liquid (1 qt./500
                           sq.ft.)

                            'iming - When needed.
       2.     For Iron (II) sulfate monohydrate:

       Type of Pesticide:   Herbicide

       Use Sites:           Ornamental herbaceous plants, ornamental lawns and
                           turf, ornamental woody shrubs and vines-terrestrial non-
                           food, outdoor residential.

       Target Pests:        Mosses

       Formulation Types Registered:
                           Granular

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Method and Rates of Application:

                   Equipment - By hand and spreader
                   Method and Rate - Ground; broadcast; sprinkle; spot
                   treatment

                          Ornamental Hervaceous Plants
                                35 Ib iron/A.
                          Ornamental Lawns
                                35 Ib kon/A.
                          Ornamental Woody Srubs and Vines
                                35 Ib iron/A.

                   Timing - When needed; Fall; Winter;  Spring; Early
                   Spring.
3.     For Iron (D) sulfate heptahydrate:

Type of Pesticide:  Herbicide

Use Sites:          Ornamental lawns and turfterrestrial non-food, Outdoor
                   Residential

Target Pests:       Mosses

Formulation Types Registered:
                   Soluble concentrate/liquid, Soluble concentrate/solid,
                   Granular

Method and Rates of Application:

                   Equipment
                   Spreader; sprinkler can; by hand; sprayer

                   Method and Rate Spray
                          Ornamental lawns and turf
                                57 Ib iron/A.
                   Timing
                   When needed.

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       C.    Regulatory History

          Pesticidal products containing iron salts were first registered in the United States
       in 1962.  In addition to active products which are currently approved for use on
       ornamental herbaceous plants, ornamental perennial, ornamental lawns, ornamental
       woody shrubs and ornamental turfs, iron salts were previously registered for
       household or domestic dwellings (indoor) and commercial institutional and industrial
       areas/premises.  The current uses include moss control in areas where moss growth is
       profuse due to high precipitation rates, primarily in the Northwest.  Currently there
       are 14 registered products with  these ingredients; 1 with iron (III) sulfate, 9 with iron
       (II) sulfate monohydrate, and 3  with iron (II) sulfate heptahydrate.

             The major use of iron salts in the United  States is non-pesticidal, as a fertilizer
       micronutrient.  Other uses include as an electrolyte  in dry cell batteries, as an animal
       feed additive, as a galvanizer, as an emulsion-breaker, as a coagulant, in water
       purification and sewage treatment, and as mordant  in textile dyeing and calico
       printing.

             Iron II ammonium sulfate is currently not being supported and is not covered
       in this Reregistration Eligibility Document.

IV.    SCIENCE ASSESSMENT OF IRON SALTS

       The Agency has conducted a  thorough review of the scientific data base for iron salts
for the purposes of determining  the reregistration eligibility of these pesticides. These
findings are summarized below. The complete references cited in the text are in the
Bibliography (Appendix C).
       A.     Physical Chemistry Assessment

              Iron (III) sulfate is a grayish-white powder, or rhombic or rhombohedral
       crystals. The commercial product usually contains about 20% water and is yellowish
       in color.  It is slowly soluble in water, rapidly soluble in the presence of a trace of
       iron (III) sulfate, sparingly soluble in alcohol, practically insoluble in acetone and
       ethyl acetate.

              Iron (II) sulfate monohydrate is white to a yellow crystal powder.  It is soluble
       in water and forms a monohydrate at 65C.

              Iron (II) sulfate heptahydrate may appear as blue green crystals or granules
       and is usually odorless.  It is  efflorescent in dry air and oxidizes in moist air forming
       a brown coating of basic iron (III) sulfate. The tetrahydrate is formed at 56.6C.
       iron (II) sulfate heptahydrate is soluble in water and practically insoluble in alcohol.

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B.     Human Health Assessment
       1.     Toxicology Assessment

             The toxicological data base on iron (III) sulfate, iron (n) sulfate
       monohydrate, and iron (II) sulfate heptahydrate is adequate and will support
       reregistration eligibility.

             a.     Acute and Subchronic Toxicity
                       ACUTE TQXICITY VALUES
TEST
Iron III Sulfate
Oral LD50~rat
Inhalation LC50--rat
Dermal LD50~rabbit
Eye Irritation
Dermal Irritation
Dermal Sensitization
RESULT
1487 - 2102 mg/kg
>1.10mg/L
> 2000 mg/kg
corrosive
corrosive
negative
TOXICITY
CATEGORY
m
III
HI
I
IV
-
                    Iron (III) sulfate, in an acute oral study in rats, had an LD50 of
              1487 mg/kg in females and 2102 mg/kg in males.  An acute dermal
              toxicity test in rabbits with Iron (III) sulfate found an LD50 greater than
              2000 mg/kg.  An acute inhalation toxicity study in  rats using iron (III)
              sulfate determined the LC50 to be greater than 1.10 mg/L.

                    Iron (II) sulfate heptahydrate, in  an acute oral study in rats,
              showed an LD,0 of 1389 mg/kg and an acute oral study in rabbits
              showed an LDto of 2778 mg/kg(4).  The LDso determined for this
              compound in mice was  1520  mg/kg(4).  A sensitization study  using
              guinea pigs with iron (II) sulfate monohydrate and iron (III) sulfate
              found no indication of contact sensitization by this compound.

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      b.     Mutagenicity

             A mutation study in E.. coli reported positive results at 30
      umol/L(4). With due regard for the continuing exposure that human
      beings have had to the iron and sulfate components of these chemicals
      over many generations, it is considered unlikely that this reported result
      in microorganisms has any  bearing on probable effects in humans or
      other mammals at the levels expected from use  of these compounds as
      pesticides.

      c.     Metabolism

             Iron sulfates are normal constituents of the diet and are
       metabolized and  utilized by the body.

       d.     Other Toxicological Consideration

             The lexicological data on iron sulfates within the Agency and in
       the literature are adequate for assessing risk to humans.  Not all of the
       toxicity data usually required  for pesticide registration or reregistration
       are necessary for the present uses of iron sulfates. There are some
       unusual factors in this case  which indicate that specific studies to fulfill
       the usual data requirements are not necessary to regulate these
       substances as pesticides.  Iron sulfates are normally present in the
       environment.  They may be present in foods naturally and as added
       ingredients.  There is no reason to expect that pesticide usage  in
       accordance with  the product label or labeling accompanying the product
       will constitute any hazard beyond that from ordinary exposure.

2.     Exposure Assessment

       a.     Dietary

             Dietary exposure to  iron (III) sulfate, iron (II) sulfate
       heptahydrate, and iron (II) sulfate monohydrate is not expected to occur
       from pesticidal use.  There are no active products involving pesticidal
       uses on food or animal feed.  Therefore, there are no tolerances or
      exemptions from the requirements of tolerances established for iron
      salts.  Since there are no lexicological endpoints of concern and no
      food uses, no risk assessment was performed for dietary exposure.
      Iron (II) sulfate is generally recognized as safe as noted in  40  CFR
       180.2(a).  The Food and Drug Administration has affirmed that iron
      (III) sulfate and iron (II) sulfate (hepta and monohydrate) are generally
      recognized as safe (GRAS)  for use in food as flavoring agents and
      nutrient supplements, respectively, with no limitations other than
                              8

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             current good manufacturing practice.

             b.     Occupational and Residential

                 As stated in Appendix A, iron (III) sulfate and iron (n) sulfate
             hepta- and monohydrate are applied to turf and ornamental lawns using
             drop and broadcast spreaders, sprinkler cans, and by hand.  These
             inorganic  salts are formulated as a granular and soluble concentrate
             (liquid and solid).  They are used as a herbicide to control moss on
             residential lawns and ornamental turf. The potential for
             mixer/loader/applicator exposure exists;  however, these inorganic salts
             are of little concern from a toxicity perspective.  Any
             mixer/loader/applicator exposure to these inorganic salts is considered
             inconsequential and no additional exposure data are required for
             reregistration eligibility.
      3.     Risk Assessment

             The human risks from both dietary and occupational exposures are
      considered to be negligible.  The general knowledge of iron  (III) sulfate and
      iron (II) sulfate hepta- and monohydrate indicate low toxicities associated with
      these compounds.  They are  used by humans as food flavoring agents and food
      nutrient supplements, and have inherent function in  the metabolic pathways  of
      humans and domestic animals.  No additional hazard or exposure data are
      required for reregistration eligibility.
C.     Environmental Assessment

       1.     Environmental Fate

             The Agency is relying on data available in the scientific literature to
       assess the environmental fate and transport of iron salts as used in pesticidal
       compounds. No environmental fate data were submitted by registrants.

             a.     Environmental Chemistry and Fate

                    Iron is the fourth most abundant element and the second most
             abundant metal in the Earth's crystal rocks.  Iron occurs in a wide
             variety of minerals among them the oxides hematite (a-Fe^) and
             magnetite (F%O4), the "hydrated oxide oxide limonite"
             (~"2Fe2(V3H2C)"), the oxyhydroxide geothite and its polymorph
             lepidocrocite (a-FeOOH and 7-FeOOH, respectively), ferrihydrite
             ("5Fe2O3'9H2O"), in  carbonates such as siderite (FeCO3), in sulfides

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(pyrite and marcasite, FeS2; chalcopyrite, CuFeS2, etc.), phosphates
(for example vivianite) and incomplex silicates. (1,2)  Weathering (that
is,  "the group of processes such as the chemical action of air,
rainwater, plants and bacterial, and the mechanical action of changes of
temperature whereby rocks on exposure to weather change in character,
decay and finally crumble into soil")(3) has considerably influenced the
distribution of iron in the earth. The oxides and hydroxide minerals of
iron are strong pigments and are responsible, for the most part, for the
brown and red colors of soils.  The presence of hematite and goethite
in soils (usually associated  with gibsite and kaolinite) is indicative of an
advanced stage of weathering.(4)

       The oxidation of ferrous iron to ferric iron (from here on
referred to as Fe(II) and Fe(III), respectively) is a very important
aspect of the chemistry  of iron  salts in the  environment.  The
oxidation is dependent on the pH and the redox potential of the medium
(water; soil) and the nature of the ligands that may be complexed to
Fe(II).  But in general,  Fe(II) is more prevalent only in very acid media
of very low oxygen content,  rather than in more basic media of normal-
to-high oxygen content, the latter being the most commonly
encountered condition.  The speciation and subsequent fate and
transport of Fe(II) and Fe(III) in the environment is, therefore,
determined by the pH and redox potential of the media and by the
nature of the ligands to which they complex. (1,2,5,6)

       Under normal environmental conditions (pH 5 to 9; aerobic
environments), the highly soluble Fe(II) salts will be rapidly oxidized to
Fe(III), but this oxidation is accompanied by the formation of less
soluble oxide and hydroxide. (7) The precipitation of Fe(III)
oxides/oxyhydroxides from oxidation  of Fe(II) salts or from  Fe(III)
salts occurs in a stepwise manner, which involves (a) formation of low-
molecular weight species of poor crystalline ordering; (b) formation of
red cationic polymers; (c) aging of the polymers, with eventual
conversion to  better defined oxide phases; (d) precipitation of
oxide/oxyhydroxide phases of well defined crystallographic
characteristics. (5) The rate of formation and the onset of the polymeric
species  are known to be strongly influenced by the nature of the
counter anion  of the salts. (5) In the case of salts of the divalent sulfate
counter anion, precipitation occurs at lower pHs than with salts of
monovalent counter anions  (for example, nitrate,  chloride).  Like in
laboratory experiments, the use of Fe(II) and Fe(II) sulfates in a
terrestrial environment leads  to the formation of insoluble
oxide/oxyhydroxide species.(7)

       The oxide/oxyhydroxide  species that form from the use of Fe


                       10

-------
(II) or Fe(III) sulfates are the same oxide/oxyhydroxide species
(principally ferrihydrite, goethite, lepidocrocite, and hematite) that are
present in soils as a result of weathering.(4,7)  Thermodynamic and
kinetic factors influence the predominance of certain species over
other. (7)  Soil temperature,  soil moisture and soil pH are significant
environmental  factors that control the distribution of these species.(8)
For example, it has been observed that goethite is commonly the sole
iron oxide in cool and temperate zones, but in the majority of tropical
or subtropical regions hematite is the predominant oxide, although it is
rarely  free of goethite. (8) The lepidocrocite-goethite association in
soils is less understood.  The predominance of lepidocrocite in a soil
has been attributed to the prevalence of conditions favoring reduction of
Fe(III) to Fe(II) followed by movement of Fe(H) to better aerated sites,
where oxidation to Fe(III) and precipitation of lepidocrocite occurs. (9)
Ferrihydrite may be considered as a young iron oxide of low order of
crystallinity.  Subsequent transformation of ferrihydrite into other
oxides of iron is dominated  by the environmental conditions.(lO)

       One of the most important properties of iron oxides/
oxydroxides (naturally occurring or formed by precipitation from iron
salts) is their very active surface chemistry.(11) The surfaces of iron
oxides and hydroxides acquire a pH-dependent charge, which controls
the adsorption of a wide range of chemical species.  Anions (such as
molybdate, sulfate, arsenate, silicate, phosphate, and organic anions) as
well as metal cations are known to chemisorb onto iron oxides and
oxyhydroxide surfaces.(6,11,12,13)  In the environment, iron
oxides/oxyhydroxides are known to serve as a sink for metals such as
copper, lead, zinc, cadmium, cobalt, nickel and manganese.(11)
Adsorption of phosphate by iron oxides/ oxyhydroxides is an important
process in soils; together with aluminum, calcium,  magnesium,
potassium, and manganese (II), they control the solubility of phosphates
in soils.(14)  Soils rich in iron oxide/oxyhydroxides (for example,
oxisols) are known to fix large amounts of phosphate fertilizers.(15)
Humic substances and other organic materials are known to adsorb onto
oxide/ oxyhydroxide particulates.  The surface properties of oxides/
oxyhydroxides determine the degree of aggregation/cementation of soil
and mineral particulates, where the iron oxides/hydroxides are believed
to behave as binding agents for the particulates.(16,17)

       Some microorganisms (mainly anaerobic bacteria) are known to
reduce Fe(III) oxide/oxyhydroxides to  Fe(II),(18) with the subsequent
re-mobilization of iron as more soluble Fe(II) species.  This occurs
predominantly in oxygen deficient soils, such  as poorly drained soils.
However, Fe(II) can be immobilized again by precipitation (for
example, as siderite, vivianite or a sulfide) or by re-oxidation.
                       11

-------
       Although acid mine drainage could potentially stabilize Fe(II) species,
       the effect of bacterially mediated oxidation by organisms such as
       Thiobacillus ferrooxidans results in formation of insoluble Fe(III)
       oxides/oxyhydroxides.(19) Free, mobile Fe(II)  or Fe(III) cations are
       not expected to persist under normal environmental conditions when the
       Fe(II) and (III) sulfates are used as herbicides to control moss in
       outdoor residential  sites or as foliar spray fertilizers to correct iron
       chlorosis. The chemical species that are produced from the reactions of
       Fe(II) and Fe(III) sulfates under environmental conditions are not
       expected to  differ from those iron minerals commonly encountered in
       soils. No unreasonable environmental effects are expected from the use
       of these  salts as directed.
       b.     Environmental Fate Assessment

              In summary, the fate and transport of Fe(II) and Fe(III) salts in
       the environment is dominated by three major processes:  (1) the pH-
       redox potential dependent oxidation of Fe(II) to Fe(III); (2) the
       formation of insoluble oxides and hydroxides that are also well known
       components of soils; and (3)  the distinct surface chemistry of the oxides
       and hydroxides of iron that control the adsorption of anions, cations
       and organic material or the adsorption of  iron species onto the surfaces
       of mineral and organic components of soils, contributing to the
       aggregation of soil particles into larger units.

              In terrestrial environments, the use of Fe(II) and Fe(HI) sulfates
       is expected to produce iron oxides and hydroxides that are no different
       from the iron oxides and hydroxides found in soils and which are
       responsible for their brown and  red colors.  Although certain bacteria
       can reduce Fe(III) to the more mobile Fe(II), reoxidation and re-
       precipitation  to Fe(III) oxides and hydroxides will rapidly immobilize
       any free Fe(II) that may form.

              Therefore, the use of iron salts as  herbicides to  control moss in
       residential outdoor ornamentals  (herbaceous and woody plants;  lawns
       and turf) or as fertilizers to correct chlorosis in plants is not expected to
       contribute significantly to the chemistry and fate of the compounds
       existing naturally in the environment.

2.     Ecological Effects

       Ecological effects data presented here are derived from the six basic
tests typically required by the Agency for assessing  ecological hazard.
                              12

-------
a.     Ecological Effects Data

       (1)    Non-Target Terrestrial

             Iron (II) sulfate heptahydrate and iron (n) sulfate
       monohydrate are classified as practically non-toxic to the
       bobwhite quail on an acute oral basis. The LDJO was 2250
       mg/kg for iron (II) sulfate heptahydrate and for sulfate
       monohydrate the LD50 is  >2150 mg/kg.  On a dietary basis,
       both active ingredients are classified as practically non-toxic for
       the bobwhite quail and the mallard duck.  The LCX for iron (II)
       sulfate heptahydrate was  >5620 ppm for both the bobwhite
       quail and the mallard duck.  For iron (n) sulfate monohydrate,
       the LC50 was >5000 ppm for both the bobwhite quail and the
       mallard  duck.

             Iron (II) sulfate heptahydrate was classified as practically
       non-toxic to rats on an acute oral basis.  The LD50 was  >5
       g/kg. Iron (III) sulfate was classified as non-toxic to male rats
       on an acute oral basis.  The LDJO was 2,102 mg/kg.  The LD50
       for female rats was 1,487 mg/kg which classifies iron (III)
       sulfate as slightly toxic on an acute oral basis.

       (2)    Non-Target Aquatic

             Iron (II) sulfate heptahydrate is the most toxic form of
       the iron salts compounds. The EC50 of 7.1 ppm for Daphnia
       pulex and LC50 of 20.8 ppm for rainbow trout classify iron salts
       as moderately toxic to aquatic invertebrates and slightly toxic to
       fish.
b.     Ecological Effects Risk Assessment

       (1)     Non-Endangered Species

              No adverse effects to avian, mammalian or aquatic
       populations are anticipated from the use of iron salts.  Iron is
       one of the most abundant elements and will be immobilized at
       the environmentally important pH range of 5-9. There is very
       little likelihood for runoff to aquatic systems since the parent
       compounds convert very rapidly to less soluble forms in  the
       environment.  Furthermore these oxidized iron compounds bind
       tightly to soil under turf.
                       13

-------
                           (2)     Endangered Species

                                  No adverse effects to terrestrial or aquatic endangered
                           species are anticipated from the use of iron salts.
V.    RISK MANAGEMENT AND REREGISTRATION DECISION FOR IRON SALTS

       A.     Determination of Eligibility

              Section 4(g)(2)(A) of FIFRA calls for the Agency to determine, after
       submission of relevant data concerning an active ingredient, whether products
       containing the active ingredient are eligible for reregistration. The Agency has
       completed its review of data from the open literature and generic data submitted by
       registrants, and has determined that the data are sufficient to support reregistration of
       products containing iron salts.  Appendix B identifies the generic data that the Agency
       reviewed  as part of its determination  of reregistration eligibility of iron salts, and lists
       the submitted studies that the Agency found acceptable.

              The data identified in Appendix B were sufficient to allow the Agency to
       assess registered uses of iron salts and to determine that these uses can be used
       without resulting in unreasonable adverse effects to humans and the environment.
       The Agency therefore finds that products containing iron salts as an active ingredient
       are eligible for reregistration. The reregistration of particular products is addressed in
       Section VI of this document.

              The Agency made its reregistration eligibility determination based upon  the
       target data base required for reregistration, the current guidelines for conducting
       acceptable studies to generate such data and the data identified in Appendix  B.
       Although  the Agency has found that current products containing iron salts are eligible
       for reregistration, it should be understood that the Agency  may take appropriate
       regulatory action, and/or require the  submission of additional data to support the
       registration of products  containing iron salts, if new information comes to the
       Agency's  attention or if the data requirements for reregistration (or the guidelines for
       generating such data) change.

              The following is  a summary of the regulatory positions and rationales for iron
       salts. Where labeling revisions are imposed, specific language is set forth in Section
       V of this document.

VI.    ELIGIBILITY  DECISION

       The Agency has sufficient information on the human  health effects of iron salts and
on its potential for causing effects in fish and wildlife and the environment when used  to
control moss growth in outdoor residential areas.  The Agency concludes that products


                                           14

-------
containing iron salts for these uses are eligible for reregistration.  Only certain generic
physical chemistry data studies on iron salts are needed as confirmatory information.  The
Agency has determined that iron salt containing products, labeled and used as specified in
this Reregistration Eligibility Document, will not pose unreasonable risks or adverse effects
to humans or the environment.

       A.     Eligible and Ineligible Uses

              The Agency has determined that all currently registered uses are eligible for
       reregistration at this time.

VH.   ACTIONS REQUIRED BY REGISTRANTS

       A.     Additional Generic Data Requirements

              The generic data base supporting  the reregistration of iron salt-containing
       products  has been reviewed and determined to be substantially complete. Although
       some of the generic product chemistry data requirements are acceptable, additional
       data are required as confirmatory. The required confirmatory data is based on the
       fact that not all companies complied  with all product chemistry guideline
       requirements.  These are part of the generic Data Call-In requirements in Appendix
       F.

       B.     Product specific data requirements

              1.    Additional Product-Specific Data Requirements

                    Based on  the reviews of the generic data for iron salts, the products
              containing iron salts are eligible for reregistration.  Section 4(g)(2)(B) of
              FIFRA calls for the Agency to obtain any  needed product-specific data
              regarding the pesticide after a determination of eligibility has been made.  The
              product specific data requirements are listed in Appendix G, the Product
              Specific Data Call-In Notice.

                    Registrants must review previous data submissions to ensure that they
              meet current EPA acceptance criteria (Appendix G; Attachment E) and if not,
              commit to conduct new studies.  If the registrant believes that previously
              submitted data meet current testing standards, then study MRID numbers
              should be cited according to the instructions in the Requirement Status and
              Registrants Response Form provided for each product.

       C.     Labeling Requirements  for Manufacturing-Use and End-Use Products

                    All labels or labeling of end-use products and Manufacturing-Use
              Products must contain the following label statements:


                                          15

-------
1.     Manufacturing-Use Products

       In addition to the above requirements under 40 CFR 156.10 and the
Pesticide Registration Handbook, for end-use products, labels and labeling of
all manufacturing-use products must contain the following Environmental
Hazards statement:

       "Do not discharge effluent containing this product into lakes, streams,
ponds, estuaries, oceans or public waters unless this product is specifically
identified and addressed in an NPDES permit. Do not discharge this product
into sewer systems without previously notifying the sewage treatment plant
authority.  For guidance, contact your State Water Board or Regional Office of
U.S. EPA."

2.     End-Use Products

       The labels and labeling of all products must comply with EPA's current
regulations and  requirements as specified in 40 CFR 156.10.  Labels must
consistently reflect any  potential eye and skin  hazard.  Please follow the
instructions in the Pesticide Reregistration Handbook with respect to labels and
labeling.
                            16

-------
IV. APPENDICES

-------
APPENDIX A - Case 4058, (Iron Salts] Chemical 034902 [Ferric sulfate]
Mil ApptcMlon Typ.. Application Timing. Appolon EqdplMiil

Fom

USES ELIGIBLE FOR REREGISTRATION
Miravnufn AppNocoon
R.I.

MiWmum
ApptcMlon DM*

M.K.*
App.

M.nf
App..*
M.n>i

B0tww^vi App<> ^
M.n.
(O^rt

^ . > * j
nMnnovvo
Entry
hmvri
I0^

0~g>.pNo
UirAMkm
Mto>Md

O-ID.^J

UMUmHMkm


NONFOOD/NONFEED USES
Ornamantal Lawns and Turf Use Groups: Terrestrial Non-Food Crop and Outdoor Residential
Spray, When needed. Hose-end Sprayer
Spray, When needed. Sprinkler can
sen.
SC/L
na
na
Dose cannot
be calculated
Dose cannot
be calculated
not
spec
not
spec
not
spec
not
spec
As needed
As needed
not spec
not spec






                                      Abbreviations used
Header:max=maximum; min=minimum; apps= applications; not spec = not specified; na=not applicable
                         Form :       SC/L=soluble concentrate/liquid

-------
APPENDIX A- Case 4058, [Iron Salts] Chemical 050502 [Ferrous sulfate heptahydratej
SITE A*orton Typ.. Aw4c.Ho, Tiling. A***** EqdfxnM

Fetm

USES ELIGIBLE FOR REREGISTRATION
MMnum AmfieBtlM
R.I.

Mninuii
AtVfeMkm Brt.

M.n/
AW-.

M.
A.
ftkuhu

Wn. hMvri
Itotw-nAw.. 
Mntbu
(dry.)

fexifaurf
6*v
* - -
wvvw
<0y)

OngntNo
UnkMkm
Alo~d

B-loxcl

UMUnAMicra


NONFOOD/NONFEED USES
Ornamental Lawns and Turf Use Groups: Terrestrial Non-Food Crop and Outdoor Residential
Sprinkle, When needed. Sprinkle can
Spray, When needed, Sprayer
Broadcast, When needed. Spreader
Broadcast, When needed, Spreader
Sprinkle, When needed, Sprinkler can
Broadcast, When needed. By hand
SC/S
SC/S
G
SC/S
SC/L
SC/S
na
na
na
na
na
na
52.272 Ib
Iron per acre
52.272 Ib
Iron per acre
1 3.9392 Ib
Iron per acre
41 .81 76 Ib
Iron per acre
Dose cannot
be calculated
41. 8176 Ib
Iron per acre
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec


















Abbreviations used
    Header:      max=maximum; min- minimum; apps= applications; not spec=not specified; na = not applicable
    Form :        G= granular; SC/L=soluble concentrate/liquid; SC/S = soluble concentrate/solid

-------
APPENDIX A- Case 4058, [Iron Salts] Chemical 050507 [Ferrous sulfate monohydratel



Form

USES ELIGIBLE FOR REREGISTRATION

R.I.

Modnuin
Af|tion RM>

Mm*
*-

M.. 
A*-.*
Mra.R>u

Min.huml
BMwn AM.. 
MU.D.I.
|iHe
IMmfam
Awd

DMhnMd

ItolMMton.



NONFOOD/NONFEED USES
Ornamental Herbaceous Plants Use Groups: Terrestrial Non-Food Crop and Outdoor Residential
Broadcast, Fall, Spreader
Broadcast, Fall, By hand
Sprinkle, When needed. Not on Label
G
G
G
na
na
na
34.848 Ib
Iron per acre
34.848 Ib
Iron
per acre
Dose cannot
be calculated
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not spec
not spec
not spec
not spec
not spec
not spec









Ornamental Lawns and Turf Use Groups: Terrestrial Non-Food Crop and Outdoor Residential
Broadcast, Early Spring, Not on Label
Broadcast, Early Spring, Spreader
Spot treatment, Fall, Not on Label
Broadcast, Spring, Spreader
Broadcast, When needed. Spreader
Broadcast, Winter, Spreader
Spot treatment, Early Spring, Not on Label
Broadcast, Fall, By hand
Broadcast, Fall, Not on Label
G
G
G
G
G
G
G
G
G
na
na
na
na
na
na
na
na
na
Dose cannot
be calculated
27.8784 Ib
Iron per acre
Dose cannot
be calculated
19.193616
Iron per acre
36.3 Ib Iron
per acre
10.0052 Ib
Iron per acre
Dose cannot
be calculated
34.848 Ib
Iron
per acre
Dose cannot
be calculated
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec
not spec




























-------
APPENDIX A- Case 4058, [Iron Salts] Chemical 050507 [Ferrous sulfate monohydrate]


Broadcast, Fall, Spreader
Form
G

DM*
na
Minim
Afl*crtonB.
34.848 Ib
Iron
per acre
Mm./
*-.
not
spec
Mn.*
*.
Mutate
not
spec
AMI. ntfflfvv
BMomnAiv*.*
M..nm
(0-V)
not spec
*fc -  	 
FMJWGVW
&MV
hMvri
ID*
not spec
OaftfH,
IMmtom
Mwmd

Dl[imd


UnlMMlfam

Ornamental Woody Shrubs and Vines Use Groups: Terrestrial Non-Food Crop and Outdoor Residential
Broadcast, Fall, Spreader
Broadcast, Fall, By hand
Sprinkle, When needed, Not on Label
G
G
G
na
na
na
34.848 Ib
Iron per acre
34.848 Ib
Iron
per acre
Dose cannot
be calculated
not
spec
not
spec
not
spec
not
spec
not
spec
not
spec
not spec
not spec
not spec
not spec
not spec
not spec









Abbreviations used
    Header:      max = maximum; min=minimum; apps=applications; not spec = not specified; na=not applicable
    Form  :       G= granular

-------
             APPENDIX B

 Table of The Generic Data Requirements and
Studies Used to Make the Reregistration Decision

-------
                              GUIDE TO APPENDIX B

    Appendix B contains listings of data requirements which support the reregistration for the
iron salts covered  by this  Reregistration  Eligibility  document.  It contains  generic  data
requirements that apply to iron salts in all products, including data requirements for which a
"typical formulation" is the test substance.

    The data table is organized in the following format:

    1.  Data Requirement (Column 1).  The data requirements are listed in the order in which
they appear in 40 CFR Part 158.  the reference numbers accompanying each test refer to the test
protocols set in the Pesticide assessment Guidelines, which are available from the National
Technical Information Service, 5285 Port Royal Road, Springfield, VA 22161 (703) 487-4650.

    2.  Use Pattern (Column 2).  This column indicates the use patterns for which the data
requirements apply. The following letter designations are used for the given use patterns:

             A Terrestrial food
             B Terrestrial feed
             C Terrestrial non-food
             D Aquatic food
             E Aquatic non-food outdoor
             F Aquatic non-food industrial
             G Aquatic non-food residential
             H Greenhouse food
             I  Greenhouse non-food
             J  Forestry
             K Residential
             L Indoor food
             M Indoor non-food
             N Indoor medical.
             O Indoor residential

    3.  Bibliographic citation (Column 3). If the Agency has acceptable  data in its files, this
column lists the identifying  number of each study.   This normally is the Master Record
Identification (MRID) number,  but may be a "GS" number if no MRID number has  been
assigned.  Refer to the Bibliography appendix for a complete citation of the study.

-------
                               IRON III SULFATE
GUIDELINE  GUIDELINE NAME

158.120 Product Chemistry
USE   BIBLIOGRAPHIC
SITES    CITATION
61-1
61-2(a)
61-2(b)
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-10
63-12
63-13
Chemical Identity
Beginning Materials and Manufacturing Process
Formulation of Impurities
Preliminary Analysis
Certification of Limits
Analytical Methods
Color
Physical State
Odor
Melting Point
Boiling Point
Density
Solubility
Dissociation Constant
pH
Storage Stability
All
All
All
All
All
All
All
All
All
All
All
All
All
All
All
All
41764501, 41764502
41764501, 41764502
41764501, 41764502
41764501, 41764502
41764501, 41764502
41764501, 41764502
DATA GAP
DATA GAP
DATA GAP
DATA GAP
DATA GAP
DATA GAP
DATA GAP
DATA GAP
DATA GAP
DATA GAP

-------
                                   IRON III SULFATE
GUIDELINE  GUIDELINE NAME

158.130 Environmental Fate
USE    BIBLIOGRAPHIC
SITES    CITATION
All environmental fate data requirements have been waived.
158.135 Toxicology
81-1
81-2
81-3
81-4
81-5
81-6
158.145
71-l(a)
71-2(a)
71-2(b)
72-l(a)
72-l(c)
72-2(a)
Acute oral tox. rat
Acute dermal tox. rabbit
Acute inhal. tox rat
Primary eye irritation-rabbit
Primary dermal irritation
Dermal sensitization/guinea pig
Ecological Effects
Acute Avian Oral Toxicity -Quail/Duck
Avian Dietary Toxicity -Quail/Duck
Acute avian diet, duck
Freshwater Fish Toxicity -Bluegill
Fish toxicity rainbow trout
Freshwater Invertebrate Toxicity
All
All
All
All
All
All

All
All
All
All
All
All
42170701
42171702
42171703
41758701
41758702
41758703

WAIVED
WAIVED
WAIVED
WAIVED
WAIVED
WAIVED

-------
                    IRON II SULFATE MONOHYDRATE
GUIDELINE  GUIDELINE NAME


158.120 Product Chemistry
USE   BIBLIOGRAPHIC
SITES   CITATION
61-1
61-2(a)
61-2(b)
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-10
63-12
63-13
Chemical Identity
Beginning Materials and Manufacturing Process
Formulation of Impurities
Preliminary Analysis
Certification of Limits
Analytical Methods
Color
Physical State
Odor
Melting Point
Boiling Point
Density
Solubility
Dissociation Constant
pH
Storage Stability
All
All
All
All
All
All
All
All
All
All
All
All
All
All
All
All
142309
142309
142309
142309
142309
142309
142309
142309
142309
142309
142309
142309
142309
142309
142309
142309

-------
                       IRON II SULFATE MONOHYDRATE
GUIDELINE  GUIDELINE NAME

158.130 Environmental Fate
USE   BIBLIOGRAPHIC
SITES    CITATION
All environmental fate data requirements have been waived.
158.135
81-1
81-2
81-3
81-4
81-5
81-6
158.145
71-l(a)
71-2(a)
71-2(b)
72-l(a)
72-l(c)
72-2(a)
Toxicology
Acute oral tox. rat
Acute dermal tox. rabbit
Acute inhal. tox rat
Primary eye irratibn-rabbit
Primary dermal irritation
Dermal sensitization/Guinea pigs
Ecological Effects
Acute Avian Oral Toxicity -Quail/Duck
Avian Dietary Toxicity -Quail/Duck
Acute avian diet, duck
Freshwater Fish Toxicity -Bluegill
Fish toxicity rainbow trout
Freshwater Invertebrate Toxicity

All
All
All
All
All
All

All
All
All
All
All
All

WAIVED
WAIVED
WAIVED
WAIVED
WAIVED
41763701

40091902
40091903
40091904
40091905
40091906
40091907

-------
                                 IRON II HEPTAHYDRATE
GUIDELINE   GUIDELINE NAME                                                USE    BIBLIOGRAPHIC
                                                                             SITES     CITATION
158.120 Product Chemistry
61-1
61-2(a)
61-2(b)
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-10
63-12
63-13
Chemical Identity
Beginning Materials and Manufacturing Process
Formulation of Impurities
Preliminary Analysis
Certification of Limits
Analytical Methods
Color
Physical State
Odor
Melting Point
Boiling Point
Density
Solubility
Dissociation Constant
pH
Storage Stability
All
All
All
All
All
All
All
All
All
All
All
All
All
All
All
All
i
i
i
i
i
i
i
i
i
i
i
i
i
i
i
i
   1  Public literature and information was provided to the Agency as part of the reregistration process. The public literature is
identified the bibliography.

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                              IRON II HEPTAHYDRATE
GUIDELINE  GUIDELINE NAME

158.130 Environmental Fate
USE    BIBLIOGRAPHIC
SITES    CITATION
All environmental fate data requirements have been waived.
158.135
81-1
81-2
81-3
81-4
81-5
81-6
158.145
71-l(a)
71-2(a)
71-2(b)
72-l(a)
72-l(c)
72-2(a)
Toxicology
Acute oral tox. rat
Acute dermal tox. rabbit
Acute Inhalation-Rat
Primary eye irration-rabbit
Primary dermal irritation
Dermal sensitization/Guinea pigs
Ecological Effects
Acute avian oral quail/duck
Acute avian diet, quail
Acute avian diet, duck
Fish toxicity bluegill
Fish toxicity rainbow trout
Invertebrate toxicity

All
All
All
All
All
All

All
All
All
All
All
All

WAIVED
WAIVED
137725
137726
137726
WAIVED

40142201
40142202
40142203
40142204
40142205
40142206

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            APPENDIX C
      IRON SALTS BIBLIOGRAPHY

Citations Considered to be Part of the Data Base
  Supporting the Reregistration of Iron Salts

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1.     CONTENTS OF BIBLIOGRAPHY.  This bibliography contains citations of all studies
      considered relevant by EPA in arriving at the positions and conclusions stated elsewhere
      in the  Reregistration Eligibility  Document.   Primary  sources  for studies in  this
      bibliography have been the body of data submitted to EPA and its predecessor agencies
      in support of past regulatory decisions.   Selections from other sources including the
      published literature, in those instances where they have been considered, are included.

2.     UNITS OF ENTRY.  The unit of entry in this bibliography is called a "study". In the
      case of published materials,  this corresponds  closely to an article.  In the case of
      unpublished materials submitted to the  Agency, the Agency has sought to identify
      documents at a level parallel to the published article from within the typically larger
      volumes in which they were submitted. The resulting "studies" generally have a distinct
      title (or at least a single subject), can stand alone for purposes of review and can be
      described with a conventional bibliographic citation.  The Agency has also attempted to
      unite basic documents and commentaries upon them, treating them as a single study.

3.     IDENTIFICATION  OF ENTRIES.  The entries in  this bibliography are sorted
      numerically by Master Record Identifier,  or "MRID number". This number is unique
      to the citation, and should be used whenever a specific reference is required. It is not
      related to the six-digit "Accession  Number" which has been  used to identify volumes of
      submitted studies (see paragraph 4(d)(4) below for further explanation). In a few cases,
      entries added to the bibliography late in the review may be preceded by a nine character
      temporary identifier.  These entries  are listed after  all MRID entries.  This temporary
      identifying number is also to be used whenever specific reference is needed.

4.     FORM OF ENTRY.  In addition  to the Master Record Identifier (MRID), each entry
      consists of a citation containing standard elements followed, in the case of material
      submitted to EPA, by a description of the  earliest  known  submission.  Bibliographic
      conventions used  reflect the standard of the American National Standards Institute
      (ANSI), expanded to provide for certain special needs.

      a. Author. Whenever the author could confidently be identified, the Agency has chosen
      to show a personal author.  When no individual was identified, the Agency has shown
      an identifiable laboratory or testing facility as the author. When no author or laboratory
      could be identified, the Agency has shown the first  submitter as the author.

      b.     Document date.   The date of the study is taken  directly  from the document.
             When the date is  followed by a question mark, the bibliographer has deduced the
             date  from  the evidence contained in the document.  When the date appears as
             (19??), the Agency was unable to determine or estimate the date of the document.
      c.     Title.  In some cases, it has been necessary for the Agency bibliographers to
             create or enhance a document title.  Any such editorial insertions are contained
             between square brackets.

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d.    Trailing parentheses. For studies submitted to the Agency in the past, the trailing
      parentheses include  (in addition to  any self-explanatory  text) the following
      elements describing the earliest known submission:

      (1)    Submission date.   The date of the earliest known  submission appears
             immediately following the word "received."

      (2)    Administrative number.   The next element immediately following  the
             word "under" is the registration number, experimental use permit number,
             petition number, or  other administrative number associated  with  the
             earliest known submission.

      (3)    Submitter.  The third element is the submitter.  When authorship is
             defaulted to the submitter, this element is omitted.

      (4)    Volume Identification (Accession Numbers).  The final element in  the
             trailing parentheses identifies the EPA accession number of the volume in
             which  the  original submission  of the  study  appears.   The  six-digit
             accession number follows the symbol "CDL," which stands for "Company
             Data Library."  This accession number is in turn followed by  an
             alphabetic suffix which shows the relative position of the study within  the
             volume.

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                                REFERENCES
1.           Cotton, F.A. and Wilkinson, G. Advanced Inorganic Chemistry. Fifth Edition.
            John Wiley and Sons, New York, 1988.

2.           Greenwood, N.N.  and Earnshaw, A. Chemistry of the Elements. Pergaman
            Press, Oxford, UK, 1984.

3.           A Dictionary of Mining. Mineral, and Related Terms, US Department of the
            Interior, Bureau of Mines, 1968.

4.           Schulze, D.G.  "An Introduction  to  Soil Mineralogy" in Minerals in Soil
            Environments. Second Edition edited by J.B. Dixon and S.B. Weed. Soil Science
            Society of America, Madison, WI, 1989, p.5.

5.           Flynn, C.M., Jr. "Hydrolysis of Inorganic Iron (HI) Salts", Chemical Reviews.
            vol. 84, 1984, pp. 31-41.

6.           Stumm, W.  and Morgan, J.J. Aquatic Chemistry- An Introduction Emphasizing
            Chemical Equilibria in Natural  Waters. Second Edition, John Wiley and Sons,
            New  York,  1981.

7.           Schwertmann, U  and Taylor, R.M. "Iron  Oxides"  in  Minerals in Soil
            Environments. Second Edition edited by J.B. Dixon and S.B. Weed. Soil Science
            Society of America, Madison, WI, 1989. pp 379-438.

8.           Reference 7, p. 398.

9.           Reference 7, p. 403.

10.         Reference 7, p. 405.

11.         Reference 7, p. 407-418.

12.         Smith, R.S.  and Akhtar. "Cationic Flotation of Oxides and Silicates" in Flotation.
            A.M.  Gaudin Memorial Volume. M.C.  Fuerstenau, Editor.  Volume I,  1976.
            Published by the Society of Mining Engineering, AIME, New York, pp 87-179.

13.         Fuerstenau,  M.C. and Palmer, B.R. "Anionic Flotation of Oxides and Silicates"
            in Flotation. A.M. Gaudin Memorial Volume. M.C. Fuerstenau, Editor, Volume
            I, 1976, pp. 146-196. Published by the Society of Mining Engineering, AIME,
            New  York.

14.         Lindsay, W.L. Chemical Equilibria in Soils. John Wiley and  Sons, New York,
            pp. 177-180.

-------
15.           Reference 7. p. 415.

16.           Reference 7. p. 416-418.

17.           Healey, T.W. "Principles of Dispersion and Aggregation of Mineral Fines", in
             Beneficiation of Mineral Fines, edited by P. Scnmasnndaran and N. Arbiter,
             Society of Mining Engineering, AIME, 1979, pp 12-161 to 12-178.

18.           Reference 7, p. 419.

19.           Karasthannasis, A.D., Evangelou, V.P. and Thompson, Y.L. "Aluminum and
             Iron Equilibria in Soil Solutions and Surface Waters of Acid Mine Watersheds",
             J. Environ.  Oual.. Vol. 17, 1988, pp. 534-543.

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                       IRON SALTS BIBLIOGRAPHY

MRID      CITATION

	      Faith, W. L., Keyes, D. B. and R. L. Clark, 1965 Industrial Chemical's. John
            Wiley & Sons, Inc., N. Y., N. Y.,  Pages 386-9.

	      Windholz, H. (Ed.)  1983. The Merck Index. 10th Edition, Merck & Co. Inc.,
            Rathway, N. J, Page 3982.

	      Weast, R. C. (Ed.) 1986. CRC Handbook of Chemistry and Physics. CRC Press,
            Inc., Boca Raton, FL, Pages 13-98.

	      Lindsay, W. L., 1979, Chemical Equilibria in Soils John Wiley & Sons, N. Y.,
            Page 131.

	      Thorpe's Dictionary of Applied Chemistry Vol. vn, 1937 Longmans, Green and
            Co, New York N.Y., Pages 57-58.

	      Material  Data  Safety  Sheet, Ferrous  Sulfate  Heptahydrate,  1987, Crown
            Technology, Inc., Indianapolis, IN.

	      Product Data Sheet; Ferrous Sulfate Heptahydrate,  Crown Technology, Inc.,
            Indianapolis, IN.

	      Material Safety Data Sheet Ferrous Sulfate Monohydrate, Q. C. Corporation
            Baltimore, MD 21200.

	      Material Safety Data Sheet Ferrous Sulfate Heptahydrate Synergy Production
            Group, Inc. Detroit, MI 48234.

	      Sax, N.  L, and Lewis, R. J. SR, 1989. Dangerous Properties of Industrial
            Materials. 7th Ed. Van Nostrand Reinhold, New York. N.Y.

00142309    Klettke, M., Product Chemistry of Ferrous  Sulfate Monohydrate., Charles H.
            Lilly Company, 1990.

00137725    Klettke, M. Primary Eye Irritation Study, Ferrous Sulfate, Project T. 1008, Harris
            Laboratories, Inc. 1990.

00137726    Klettke, M., Primary Skin Irritation Study, Project T. 1009, Harris Laboratories,
            Inc. 1990.

40091902    Fletcher, D. (1986) Acute Oral Toxicity Study with Ferrous Sulfate Monohydrate
            in Bobwhite Quail: Laboratory Project ID: BLAL No. 85 QD 61. Unpublished
            study prepared by Bio-Life Associates, Ltd.  27 p.

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MRTO

40091903



40091904



40091905
40091906
 40091907
40142201
40142202
40142203
40142204
40142205
CITATION

Fletcher, D. (1986) 8-Day Dietary LC50 Study with Ferrous Sulfate Monohydrate
in Mallard Ducklings: Laboratory Project ID: BLAL No. 85 DC 63. Unpublished
study prepared by Bio-Life Associates, Ltd. 28 p.

Fletcher, D. (1986) 8-Day Dietary LC^ Study with Ferrous Sulfate Monohydrate
in Bobwhite Quail: Laboratory Project ID: BLAL No. 85 QC 61. Unpublished
study prepared by Bio-Life Associates, Ltd. 28 p.

Surprenant, D.  (1986)  Acute  Toxicity  of Ferrous Sulfate  Monohydrate  to
Rainbow   Trout:   Laboratory   Project   ID:   BW-86-11-2227:   Study
#11501.0886.6100.103. Unpublished study prepared  by Springborn Bionomics,
Inc. 19 p.

Surprenant, D. (1986) Acute Toxicity  of Ferrous  Sulphate  Monohydrate  to
Bluegill: Laboratory Project ID: BW-86-11-2228: Study #11501.0886.6100,100.
Unpublished study prepared by Springborn Bionomics, Inc. 19 p.

Surprenant, D.  (1986)  Acute  Toxicity  of Ferrous Sulfate Monohydrate  to
Daphnids  (Daphnia magna): Laboratory  Project ID: BW-86-112229: Study
#11501.0886.6100.110. Unpublished study prepared  by Springborn Bionomics,
Inc. 18 p.

Grimes, L; Jaber, M. (1986) Ferrous Sulfate Heptahydrate: An Acute Oral
Toxicity Study with the Bobwhite: Laboratory Project ID:  223-103. Unpublished
study prepared by Wildlife International Ltd. 18 p.

Grimes, J.; Jaber, M. (1986) Ferrous Sulfate Heptahydrate: A Dietary LC50
Study with the Bobwhite:  Laboratory Project ID: 223101. Unpublished study
prepared by Wildlife International Ltd. 17 p.

Grimes, J.; Jaber, M. (1986) Ferrous Sulfate Heptahydrate: A Dietary LC50
Study with the Mallard:  Laboratory Project  ID:  223102. Unpublished study
prepared by Wildlife International Ltd.

Surprenant, D. (1986) Acute Toxicity of Ferrous  Sulfate Heptahydrate ...to
Bluegill (Lepomis macrochirus): Bionomics Report #BW-86-12-2262: Bionomics
Study  #1297.0786.6101.100. Unpublished study  prepared  by Springborn
Bionomics, Inc. 6 p.

Surprenant, D. (1986) Acute Toxicity  of Ferrous  Sulfate  Heptahydrate...to
Rainbow Trout (Salmogairdneri): Bionomics Report #BW-87-3-2317: Bionomics
Study  #1297.0786.6101.103. Unpublished study  prepared  by Springborn
Bionomics, Inc. 7 p.

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MRP)                          CITATION

40142206    Surprenant,  D. (1986) Acute  Toxicity of Ferrous Sulfate Heptahydrate...to
             Daphnids (Daphnia pulex): Bionomics Report #BW-87-32318: Bionomics Study
             #1297.0786.6101.110. Unpublished study prepared by Springborn Bionomics,
             Inc. 6 p.

41758701    Robbins, G., Pimary Eye Irritatancy Study in Rabbits, Ferric Sulfate, Fern Floe:
             Lab Project No. D3082. Unpublished Study prepared by Cosmopolitan Safety
             Evaluation, 1990.

41758702    Robbins, G., Pimary Eye Irritatancy Study in Rabbits, Ferric Sulfate, Fern Floe:
             Lab Project No. E3082. Unpublished Study prepared by Cosmopolitan Safety
             Evaluation, 1990.

41758703    Robbins, G., Guinea Pig Sensitization, Ferric Sulfate, Ferri Floe:  Lab Project
             No. F3082. Unpublished  Study prepared by Cosmopolitan Safety Evaluation,
             1991.

41763701    Robbins, G.  (1990) Guinea Pig Sensitization (Buhler): WGM-30  Brand: Lab
             Project Number: F3081. Unpublished study prepared by Cosmopolitan Safety
             Evaluation, Inc. 19 p.

41764501    Gohlke, A., Product Identity and Disclosure of Ingredients, Tennessee Chemical
             Company's Ferri-Floc, Ferric Sulfate Lab Project No 1991-1. Unpublished Study
             prepared by Tennessee Chemical Co., 1991.

41764501    Gohlke, A., Analysis and Certification of Ingredinents in Tennessee Chemical
             company's Ferri-Floc, Tennessee Chemical Company's Ferri-Floc, Ferric Sulfate
             Lab Project No 1991-2. Unpublished Study prepared by Tennessee Chemical Co.,
             1991.

42171701    Robbins, G. (1992) Acute Oral  Toxicity in Rats: Ferric Sulfate, Ferri Floe: Lab
             Project Number: A3251. Unpublished study prepared by Cosmopolitan Safety
             Evaluation, Inc. 28 p.

42171702    Robbins, G. (1991) Acute Dermal Absorption in Rabbits: Ferric Sulfate, Ferri
             Floe: Lab Project Number: B3251. Unpublished study prepared by Cosmopolitan
             Safety Evaluation, Inc. 24 p.

42171703    Robbins, G. (1991) Acute Inhalation Study in Rats: Ferric Sulfate, Ferri Floe:
             Lab Project Number: C3251. Unpublished study prepared by Cosmopolitan Safety
             Evaluation, Inc. 34 p.

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                               APPENDIX D
                     List of Available Related Documents

      The following is a list of available documents related to iron salts. Its purpose is to
provide a path to more detailed information if it is needed. These accompanying documents are
part of the Administrative Record for iron salts and are included in the EPA's Office of Pesticide
Programs Public Docket.

      1.     Health and Environmental Effects Science Chapters

      2.     Detailed Label Usage Information System (LUIS) Report

      3.     Iron salts RED Fact Sheet

      4.     PR Notice 91-2 (included in  this appendix) pertains to  the Label Ingredient
             Statement

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Appendix E, F, & G are separate
          docucments

-------
       APPENDIX E

Pesticide Reregistration Handbook
      and PR Notice 91-2

-------
PR Notice 91-2

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               UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

                             WASHINGTON, D.C.  20460
                                                         OFFICE OF
                                                     PREVENTION. PESTICIDES
                                                     AND TOXIC SUBSTANCES
                          PR NOTICE 91-2

         NOTICE TO MANUFACTURERS, PRODUCERS, FORMULATORS,
                  AND REGISTRANTS  OF  PESTICIDES

ATTENTION:   Persons Responsible for  Federal Registration of
Pesticide Products.

SUBJECT:     Accuracy of  Stated Percentages for  Ingredients
Statement

I. PURPOSE:

     The purpose of this  notice is to clarify the  Office of
Pesticide Program's policy with respect to  the statement of
percentages in a pesticide's  label's  ingredient  statement.
Specifically, the amount  (percent  by  weight)  of  ingredient(s)
specified in the ingredient statement on the label must  be stated
as the nominal concentration  of such  ingredient(s),  as that term
is defined in 40 CFR 158.153(i). Accordingly,  the  Agency has
established the nominal concentration as the only  acceptable
label claim for the amount of active  ingredient  in the product.

II. BACKGROUND

     For some time the Agency has  accepted  two different methods
of identifying on the label what percentage is claimed for the
ingredient(s) contained in a  pesticide.  Some applicants  claimed a
percentage which represented  a level  between the upper and the
lower certified limits. This  was referred to as  the  nominal
concentration. Other applicants claimed the lower  limit  as the
percentage of the ingredient(s)  that  would  be expected to be
present in their product  at the end of the  product's shelf-life.
Unfortunately, this led to a  great deal of  confusion among the
regulated industry, the regulators, and the consumers as to
exactly how much of a given ingredient was  in a  given product.
The Agency has established the nominal concentration as  the only
acceptable label claim for the amount of active  ingredient in the
product.
     Current regulations  require that the percentage listed in
the active ingredient statement be as precise as possible
reflecting good manufacturing practices 40  CFR 156.10(g)(5). The
certified limits required for each active ingredient are intended
to encompass any such "good manufacturing practice"  variations 40
CFR 158.175 (c) (3) .
     The upper and lower  certified limits,  which must be proposed
in connection with a product's registration,  represent the

-------
amounts of an ingredient that may legally be present 40 CFR
158.175. The lower certified limit is used as the enforceable
lower limit for the product composition according to FIFRA
section 12(a)(l)(C), while the nominal concentration appearing on
the label would be the routinely achieved concentration used for
calculation of dosages and dilutions.

     The nominal concentration would in fact state the greatest
degree of accuracy that is warranted with respect to actual
product composition because the nominal concentration would be
the amount of active ingredient typically found in the product.

     It is important for registrants to note that certified
limits for active ingredients are not considered to be trade
secret information under FIFRA section 10(b). In this respect the
certified limits will be routinely provided by EPA to States for
enforcement purposes, since the nominal concentration appearing
on the label may not represent the enforceable composition for
purposes of section 12(a)(1)(C).

III. REQUIREMENTS

     As described below under Unit V. " COMPLIANCE SCHEDULE,*1 all
currently registered products as well as all applications for new
registration must comply with this Notice by specifying the
nominal concentration expressed as a percentage by weight as the
label claim in the ingredient(s)  statement and equivalence
statements if applicable (e.g., elemental arsenic, metallic zinc,
salt of an acid). In addition,  the requirement for performing
sample analyses of five or more representative samples must be
fulfilled. Copies of 'the raw analytical data must be submitted
with the nominal ingredient label claim. Further information
about the analysis requirement may be found in the 40 CFR
158.170. All products are required to provide certified limits
for each active, inert ingredient, impurities of toxicological
significance(i.e., upper limit(s) only) and on a case by case
basis as specified by EPA.  These limits are to be set based on
representative sampling and chemical analysis(i.e., quality
control) of the product.

     The format of the ingredient statement must conform to 40
CFR 156-Labeling Requirements For Pesticides and Devices.

     After July 1, 1997, all pesticide ingredient Statements must
be changed to nominal concentration.

-------
IV. PRODUCTS THAT REQUIRE EFFICACY DATA

     All pesticides are required to be efficacious. Therefore,
the certified lower limits may not be lower then the minimum
level to achieve efficacy. This is extremely important for
products which are intended to control pests which threaten the
public health, e.g., certain antimicrobial and rodenticide
products. Refer to 40 CFR 153.640.

     In those cases where efficacy limits have been established,
the Agency will not accept certified lower limits which are below
that level for the shelf life of the product.

V. COMPLIANCE SCHEDULE

     As described earlier, the purpose of this Notice is to make
the registration process more uniform and more manageable for
both the agency and the regulated community. It is the Agency's
intention to implement the requirements of this notice as
smoothly as possible so as not to disrupt or delay the Agency's
high priority programs, i.e., reregistration, new chemical, or
fast track (FIFRA section 3(c)(3)(B). Therefore,
applicants/registrants are expected to comply with the
requirements of this Notice as follows:

     (1)  Beginning July 1, 1991, all new product registrations
          submitted to the Agency are to comply with the
          requirements of this Notice.

     (2)  Registrants having products subject to reregistration
          under FIFRA section 4 (a) are to comply with the
          requirements of this Notice when specific products are
          called in by the Agency under Phase V of the
          Reregistration Program.

     (3)  All other products/applications that are not subject to
          (1) and (2) above will have until July 1, 1997, to
          comply with this Notice. Such applications should note
          "Conversion to Nominal Concentrations on the
          application form. These types Or amendments will not be
          handled as "Fast Track" applications but will be
          handled as routine requests.

VI. FOR FURTHER INFORMATION

Contact Tyrone Aiken for information or questions concerning
this notice on (703) 557-5024
                                 Ann* S. Lindsay, Director
                                 Registration Division (H-7505

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 APPENDIX F
Generic Data Call-In

-------
    Attachment A



Chemical Status Sheet

-------
                   IRON SALTS: DATA CALL-IN CHEMICAL STATUS SHEET
INTRODUCTION
      You have been sent this Generic Data Call-In Notice because you have produces)
containing Iron Salts.

      This Generic Data Call-In Chemical Status Sheetr contains an overview of data
required by this notice, and point of contact for inquiries pertaining to the reregistration of
icon salts. This attachment is to be used in conjunction with (1) the Generic Data Call-In
Notice, (2) the Generic Data Call-In Response Form (Attachment B), (3) the Requirements
Status and Registrant's Form (Attachment C), (4) a list of registrants receiving this DCI
(Attachment D), (5) the EPA Acceptance Criteria (Attachment E), and (6) the Cost Share and
Data Compensation Forms in replying to this Iron Salts Generic Data Call-In (Attachment F).
Instructions and guidance accompany  each form.
DATA REQUIRED BY THIS NOTICE

       The additional data requirements needed to complete the generic database for iron
salts are contained in  the Requirements Status and Registrant's Response. Attachment C.
The Agency has concluded that additional product chemistry data on iron salts are needed.
These data are needed to fully complete the reregistration of all eligible zinc salts products.
 INQUIRIES AND RESPONSES TO THIS NOTICE

       If you have any questions regarding the generic data requirements and procedures
 established by this Notice, please contact Yvonne Brown at (703) 308-8073.

       All responses to this Notice for the generic data requirements should be submitted to:

             Yvonne Brown, Chemical Review Manager
             Accelerated Reregistration Branch
             Special Review and Registration Division (H7508W)
             Office of Pesticide Programs
             U.S. Environmental Protection Agency
             Washington, D.C.  20460

             RE: IRON SALTS

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                 Attachment B




Generic DCI Response Forms (Form A) plus Instructions

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   SPECIFIC INSTRUCTIONS FOR THE GENERIC DATA CALL-IN RESPONSE FORM

This Form is designed to be used to respond to call-ins for generic and product specific data for th
purpose of reregistering pesticides under the Federal Insecticide Fungicide and Rodenticide Act. F
out this form each time you are responding to a data call-in for which EPA has sent you the form
entitled "Requirements Status and Registrant's Response."

Items  1-4 will have been preprinted on the form Items 5 through 7 must be completed by the
registrant as appropriate Items 8 through  11  must be completed by  the registrant before submitting a
response to the Agency.

Public reporting burden for this collection of information is estimated to average 15 minutes per
response, including time for reviewing instructions, searching existing data sources, gathering and
maintaining the data needed, and completing and reviewing the collection of information.  Send
comments regarding the burden estimate or any other aspect of this collection of information,
including suggesting for reducing this burden, to Chief, Information Policy Branch, PM-223, U S
Environmental Protection Agency, 401 M St,  S  W ,  Washington,  D  C 20460; and to the Office o
Management and Budget, Paperwork Reduction Project 2070-0107, Washington, D C 20503

INSTRUCTIONS

Item 1       This item identifies your company name, number and address.

Item 2       This item identifies the ease number, ease name, EPA chemical number and chemic
             name.

Item 3       This item identifies the date and type of data call-in.

Item 4       This item identifies the EPA product registrations relevant to the data call-in. Pleas
             note that you are also responsible for informing the Agency of your  response
             regarding any product that  you believe  may be covered by this data call-in but that
             not listed by the  Agency in Item 4. You must bring any such apparent omission to
             the Agency's attention within the period required for submission of this response
             form.

Item 5       Cheek this item for each product registration you wish  to cancel voluntarily.  If a
             registration number is listed for a product for which  you previously requested
             voluntary cancellation, indicate in Item 5 the date of that request.  You do not need to
             complete any item on the Requirements Status and Registrant's Response Form for
             any product that  is voluntarily cancelled.

Item 6a      Check this item if this data call-in  is for generic data as indicated in  Item 3 and if y
             are eligible for a Generic Data Exemption for the chemical listed in  Item 2 and used
             in the subject product.   By electing this exemption,  you agree to the terms and
             conditions of a Generic Data Exemption as explained in the Data Call-In Notice.

-------
              If you are eligible for or claim a Generic Data Exemption, enter the EPA registratio
              Number of each registered source of that active ingredient that you use in your
              product.

              Typically, if you purchase an EPA-registered product from one or more other
              producers (who, with respect to the incorporated product, are in compliance with th
              and-any other outstanding Data Call-In Notice), and incorporate that product into al
              your products, you may complete this item for all products listed on this form If,
              however, you produce the active ingredient yourself, or use any unregistered produc
              (regardless of the fact that some of your sources are registered),  you may not claim a
              Generic Data Exemption and you may not select this item.

Item 6b       Check this Item if the data call-in is a generic data call-in as indicated in Item 3 and if
              you are agreeing to satisfy the generic data requirements of this data call-in.  Attac
              the Requirements Status and Registrant's Response Form that Indicates how you wil
              satisfy those requirements.

Item 7a       Check this item if this call-in if a data call-in as indicated in Item 3 for a
              manufacturing use product (MUP), and if your product is a manufacturing use
              product for which you agree to supply product-specific data. Attach the Requireme
              Status and Registrants' Response Form that indicates how you will satisfy those
              requirements.

Item 7b       Check this item if this call-in is a data call-in for an end use product (EUP) as
              indicated in Item 3 and if your product is an end use product for which you agree to
              supply product-specific data.  Attach the Requirements Status and Registrant's
              Response Form that indicates how you will satisfy those requirements.

Item 8        This certification statement must be signed by an authorized representative of your
              company and the person signing must include his/her title.  Additional pages used in
              your response must be initialled and dated  in the space provided for the certification

Item 9        Enter the date of signature.

Item 10       Enter the name of the person EPA should contact with questions regarding your
              response.

Item 11       Enter the phone number of your company contact.

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                 Attachment C

Requirements Status and Registrants' Response Forms
             (Form B) plus Instructions

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SPECIFIC INSTRUCTIONS FOR COMPLETING THE REQUIREMENTS STATUS AND
REGISTRANTS RESPONSE FORM

Generic Data

This form is designed to be used for registrants to respond to eall-in- for generic and
produet-speeifie data as part of EPA's reregistration program under the Federal Insecticide
Fungicide and Rodenticide Act.  Although the form is the same for both product specific and
generic data, instructions for completing the forms differ slightly.  Specifically, options for
satisfying product specific data reguirements do not include (1) deletion of uses or (2) request for a
low volume/minor use waiver.  These instructions are for completion of generic data reguirements

EPA has developed this form individually for each data call-in addressed  to each registrant, and ha
preprinted this form with a number of items. DO NOT use this form for any other active
ingredient.

Items 1 through 8 (inclusive) will have been preprinted on the form. You must complete all other
items on this form by typing or printing legibly.

Public reporting burden for this collection of information is estimated to average 30 minutes per
response, including time for reviewing  instructions, searching existing data sources, gathering and
maintaining the data needed, and completing and reviewing the collection of information. Send
comments regarding the burden estimate or any other aspect of this collection of information,
including suggesting for reducing this burden, to Chief, Information Policy Branch, PM-223, U.S.
Environmental Protection Agency, 401  M St., S.W., Washington, D.C. 20460; and to the Office of
Nanagement and Budget, Paperwork Reduction Project 2070-0107, Washington, D.C. 20503.

INSTRICIONS

Item 1.      This item identifies your company name, number, and address.

Item 2.      This Item identifies the case number, case name, EPA chemical number and chemic
             name.

Item 3.      This item identifies the date and type of data call-in.

Item 4.      This item identifies the guideline reference numbers of studies reguired to support t
             product(s) being reregistered. These guidelines, in addition to requirements specified
             in the Data Call-In Notice, govern the conduct of the required studies.

Item 5.      This item identifies the study title associated with the guideline reference number an
             whether protocols and 1, 2, or 3-year progress reports are  reguired to be submitted in
             connection with the study.  As noted in Section ffl of the Data Call-In Notice, 90-d
             progress reports are required for all studies.

             If an asterisk appears in Item 5, EPA has attached information relevant to this
             guideline reference number to the Reguirements Status and Registrant's Response
             Form.

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Item 6.       This item identifies the code associated with the use pattern of the pesticide. A brief
             description of each code follows:

             A.                 Terrestrial food
             B.                 Terrestrial feed
             C.                 Terrestrial non-food
             D.                 Aquatic food
             E.                 Aquatic non-food outdoor
             F.                 Aguatic non-food industrial
             G.                 Aquatic non-food residential
             H.                 Greenhouse food
             I.                  Greenhouse non-food crop
             J.                  Forestry
             K.                 Residential
             L.                 Indoor food
             M.                 Indoor non-food
             N.                 Indoor medical
             O.                 Indoor residential

 Item 7.      This item identifies the code assigned to the substance that must be used for testing.
             A brief description of each code follows.

       EP                       End-Use Product
       MP                      Manufacturing-Use Product
       MP/TGAI                 Manufacturing-Use Product and Technical Grade Active
                                Ingredient
       PAI                      Pure Active Ingredient
       PAI/M                   Pure Active Ingredient and Metabolites
       PAI/PAIRA               Pure Active Ingredient or Pure Active Ingredient Radiolabelled
       PAIRA                   Pure Active Ingredient Radiolabelled
       PAIRA/M                 Pure Active Ingredient Radiolabelled and Metabolites
       PAIRA/PM               Pure Active Ingredient Radiolabelled and Plant Metabolites
       TEP                      Typical End-Use Product
       TEP _ *                  Typical End-Use Product, Percent Active Ingredient Specified
       TEP/MET                 Typical End-Use Product and Metabolites
       TEP/PAI/M               Typical End-Use Product or Pure Active Ingredient and
                                Metabolites
       TGAI/PAIRA             Technical Grade Active Ingredient or Pure Active Ingredient
                                Radiolabelled
       TGAI                    Technical Grade Active Ingredient
       TCAI/TEP                Technical Grade Active Ingredient or Typical End-Use Produc
       TGAI/PAI                 Technical Grade Active Ingredient or Pure Active Ingredient
       MET                     Metabolites
       IMP                      Impurities
       DEGR                    Degradates

       *See: guideline comment

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Item 8.       This item Identifies the time frame allowed for submission of the study or protocol
             identified in item 2. The time frame runs from the date of your receipt of the Data
             Call-In Notice.

Item 9.       Enter the appropriate Response Code or Codes to show how you intend to comply
             with each data reguirement. Brief descriptions of each code follow. The Data Call-I
             Notice contains a fuller description of oach of these options.

             1.     (Developing Data) I will conduct a new study  and submit it within the time
                    frames specified in item 8 above. By indicating that I  have chosen this option
                    I certify that I will comply with all the reguirements pertaining to the
                    conditions for submittal  of this study as outlined in the Data Call-In Notice a
                    that I will provide the protocol and progress reports reguired in item 5 above

             2.     (Agreement to Cost Share) I have entered into an agreement with one or mo
                    registrants to develop data jointly. By indicating that I have chosen  this optio
                    I certify that I will comply with all the requirements pertaining to sharing in
                    the cost of developing data as outlined in the Data Call-In Notice.

             3.     (Offer to Cost Share) I have made an offer to  enter into an agreement with o
                    or more registrants to develop data jointly. I am submitting a copy of the for
                    "Certification of Offer to Cost Share in the Development of Data" that
                    describes this offer/agreement.  By indicating  that I have chosen this option, I
                    certify that I will  comply with all the requirements pertaining to making an
                    offer to share in the cost of developing data as outlined in the Data Call-In
                    Notice.

             4.     (Submitting Existing Data) I am submitting an existing study that has never
                    before been submitted to EPA. By indicating that I have chosen this option, I
                    certify that this study meets all the requirements pertaining to the conditions
                    for submittal of existing data outlined in the Data Call-In Notice and I have
                    attached the needed supporting information along with this response.

             5.     (Upgrading a Study) I am  submitting or citing data to upgrade a study that
                    EPA has classified as partially acceptable and  potentially upgradeable. By
                    indicating that I have chosen this option, I certify that I have met all the
                    requirements pertaining  to the conditions for submitting or citing existing dat
                    to upgrade a study described in the Data Call-In Notice. I am indicating on
                    attached correspondence the Master Record Identification Number (MRID) th
                    EPA has assigned to the data that I am citing as well as the MRID of the stu
                    I am attempting to upgrade.

             6.     (Citing a Study) I am citing an existing study that has been previously
                    classified by EPA as acceptable, core, core minimum, or a study that has no
                    yet been reviewed by the Agency. I am providing the Agency's classfication of
                    the study.

             7.     (Deleting Uses) I  am attaching an application  for amendment to my

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                    registration deleting the uses for which the data are required.

             8.     (Low Volume/Minor Use Waiver Request) I have read the statements
                    concerning low volume-minor use data waivers in the Data Call-in Notice an
                    I request a low-volume minor use waiver of the data reguirement. I am
                    attaching a detailed justification to support this waiver request including,
                    among other things, all information reguired to support the request. I
                    understand that, unless modified by the Agency in writing, the data
                    reguirement as stated in the Notice governs.

             9.     (Reguest for Waiver of Data) I have read the statements concerning data
                    waivers other than lowvolume minor-use data waivers in the Data Call-In
                    Notice and I request a  waiver of the data requirement. I am attaching an
                    identification of the basis for this waiver and a detailed justification to suppo
                    this waiver request. The justification includes, among other things, all
                    information required to support the reguest. I understand that, unless modifie
                    by the Agency in writing, the data reguirement as stated in the Notice gover

Item 10.      This item must be signed by an authorized representative of your company. The
             percon signing must include his/her title, and must initial and date all other pages o
             this form.

Item 11.      Enter the date of signature.

Item 12.      Enter the name of the person EPA should contact with questions regarding your
             response.

Item 13.      Enter the phone number of your company contact.

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         Attachment D
List of Registrants) sent this DCI

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    APPENDIX G
Product Specific Data Call-In

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 ATTACHMENT A
Chemical Status Sheet

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                IRON SALTS: DATA CALL-IN CHEMICAL STATUS SHEET
INTRODUCTION

       You have been sent this Product Specific Data Call-In Notice because you have produces)
containing iron salts.

       This Product Specific Data Call-In Chemical Status Sheet, contains an overview of data
required by this notice, and point of contact for inquiries pertaining to the reregistration of iron
salts. This attachment is to be used in conjunction with (1) the Product Specific Data Call-in
Notice, (2) the Product Specific Data Call-in Response Form (Attachment B), (3) the Requirement
Status and Registrant's Form (Attachment C), (4) EPA's Grouping of End-Use Products for Meeti
Acute Toxicology Data Requirement (Attachment D), (5) the EPA Acceptance Criteria (Attachmen
E), (6) a list of registrants receiving this DCI (Attachment F) and (7) the Cost Share and Data
Compensation Forms in replying to this iron salts Product Specific Data Call-in (Attachment G).
Instructions and guidance accompany each form.
 DATA REQUIRED BY THIS NOTICE

       The additional data requirements needed to complete the database for iron salts are containe
 in the Requirements Status and Registrant's Response. Attachment C.  The Agency has concluded
 that additional data on iron salts are needed for specific products. These data are required to be
 submitted to the Agency within the timeframe listed.  These data are needed to fully complete the
 reregistration of all eligible iron salts products.


 INQUIRIES AND RESPONSES TO THIS NOTICE

       If you have any questions regarding the generic database of iron salts, please contact Yvon
 Brown at (703) 308-8073.

       If you have any questions regarding the product specific data requirements and procedures
 established by this Notice, please contact Joanne Miller (703) 305-7830.

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All responses to this Notice for the Product Specific data requirements should be submitted
to:

      Joanne Miller, Product Manager Team 23
      Herbicide/Fungicide Branch
      Registration Division (H7505C)
      Office of Pesticide Programs
      U.S. Environmental Protection Agency
      Washington, D.C. 20460

      RE: IRON SALTS

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                   ATTACHMENT B

PRODUCT SPECIFIC DATA CALL-IN RESPONSE FORMS (Form A) PLUS
                    INSTRUCTIONS

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     INSTRUCTIONS FOR COMPLETING THE "DATA CALL-IN RESPONSE" FORM
                             FOR PRODUCT SPECIFIC DATA

Item 1-4.     Already completed by EPA.

Item 5.       If you wish to voluntarily cancel your product, answer "yes." If you choose this
             option, you will not have to provide the data required by the Data Call-in Notice an
             you will not have to complete any other forms. Further sale and distribution of your
             product after the effective date of cancellation must be in accordance with the Existi
             Stocks provision of the Data Call-In Notice (Section IV-C).

Item 6.       Not applicable since this form calls in product specific data only. However, if your
             product is identical to another product and you qualify for a  data exemption, you
             must respond with "yes" to Item 7a (MUP) or 7B (EUP) on this form, provide the
             EPA registration numbers of your source(s); you would not complete the
             "Requirements Status and Registrant's Response" form. Examples of such products
             include repackaged products and Special Local Needs (Section 24c) products whic
             are identical to federally registered products.

Item 7a.      For each manufacturing use product (MUP) for which you  wish to maintain
             registration, you must agree to satisfy the data requirements by responding "yes."

Item 7b.      For each end use product (EUP) for which you wish to maintain registration, you
             must agree to satisfy the data requirements by responding "yes." If you are requesti
             a data waiver, answer "yes" here; in addition, on  the "Requirements Status and
             Registrant's Response" form under Item 9, you must respond with Option 7 (Waive
             Request) for each study for which you are requesting a waiver. See Item 6 with
             regard to identical products and data exemptions.

Items 8-11.   Self-explanatory.

NOTE:              You may provide additional information that does not fit on this  form in a
                    signed letter that accompanies this form. For example, you may wish to repo
                    that your product has already been transferred to another company or that yo
                    have already voluntarily cancelled this product. For these cases, please suppl
                    all relevant details so that EPA can ensure that its records are correct.

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             ATTACHMENT C

PRODUCT SPECIFIC REQUIREMENT STATUS AND
         REGISTRANT'S RESPONSE
     FORMS (Form B) PLUS INSTRUCTIONS

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       INSTRUCTIONS FOR COMPLETING THE "REQUIREMENTS STATUS AND
          REGISTRANT'S RESPONSE" FORM FOR PRODUCT SPECIFIC DATA

Item 1-3      Completed by EPA. Note the unique identifier number assigned by EPA in Item 3
             This number must be used in the transmittal document for any data submissions
             in response to this Data Call-In Notice.

Item 4.       The guideline reference numbers of studies required to support the product's
             continued registration are identified. These guidelines, in addition to the requiremen
             specified in the Notice, govern the conduct of the required studies. Note that series 61
             and 62 in product chemistry are now listed under 40 CFR 158.155 through 158.180
             Subpart C.

Item 5.       The study title associated with the guideline reference number is identified.

Item 6.       The use pattern(s) of the pesticide associated with the product specific requirements is
             (are) identified. For most product specific data requirements, all use patterns are
             covered by the data requirements. In the case of efficacy data, the required studies
             only pertain to products which have the use sites and/or pests indicated.

Item 7.       The substance to be tested is identified by EPA. For product specific data, the
             product as formulated for sale and distribution is the test substance, except in rare
             cases.

Item 8.       The due date  for submission of each study is identified. It is normally based on 8
             months after issuance of the Reregistration Eligibility Document unless EPA
             determines that a longer time period is necessary.

Item 9.       Enter only one of the following response Codes for each data requirement to
             show how you intend to comply with the data requirements listed in this table.
             Fuller descriptions of each option are contained in the Data Call-In Notice.

       1.     I will generate and submit data by the specified due date (Developing Data). By
             indicating that I have chosen this option, I certify that I will comply with all the
             requirements pertaining to the conditions  for submittal of this study as outlined  in th
             Data Call-In Notice.

      2.     I have entered into an agreement with one or more registrants to develop data jointl
             (Cost Sharing). I am submitting a Copy  of this agreement. I understand that this
             option is available only for acute toxicity or certain efficacy data and only if EPA
             indicates in an attachment to this Notice that my product is similar enough to anothe
             product to qualify for this option. I certify that another party in the agreement is
             committing to submit or provide the required data: if the required study  is not
             submitted on time, my product may be subject to suspension.

      3.     I have made offers to share in the cost to develop data  (Offers to Cost Share). I
             understand that this option is available only for acute toxicity or certain  efficacy dat
             and only if EPA indicates in an attachment to this Data Call-In Notice that my

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      product is similar enough to another product to qualify for this option. I am
      submitting evidence that I have made an offer to another registrant (who has an
      obligation to submit data) to share in the cost of that data. I am also submitting a
      completed "Certification of Offer to Cost Share in the Development Data" form  I
      am including a copy of my  offer and proof of the other registrant's receipt of that
      offer. I am identifying the party which is committing to submit or provide the
      required data: if the required study is not submitted on time, my product may be
      subject to suspension. I understand  that other terms under Option 3 in the Data
      Call-In Notice (Section m-C.l.) apply as well.

4.    By the specified due date, I will submit an existing study that has not been submitte
      previously to the Agency by anyone (Submitting an Existing Study). I certify that
      this study will meet all the requirements for submittal of existing data outlined in
      Option 4 in the  Data Call-In Notice (Section m-C.l.) and will meet the attached
      acceptance criteria  (for acute toxicity and product chemistry data). I will attach the
      needed supporting information along with this response. I also certify that I have
      determined that this study will fill the data requirement for which I have indicated t
      choice.

5.    By the specified due date, I will submit or cite data to upgrade  a study classified by
      the Agency as partially acceptable and upgradable (upgrading a Study). I will
      submit evidence of the Agency's review indicating that the study may be upgraded
      and what information is required to do so. I will provide the MRID or Accession
      number of the study at the due date. I understand that the conditions for this option
      outlined Option 5 in the Data Call-In Notice (Section m-C.l.) apply.

6.    By the specified due date, I will cite an existing study that the Agency has classified
      as acceptable or an existing study that has been submitted but not reviewed by the
      Agency (Citing an Existing Study). If I am citing another registrant's study, I
      understand that  this option is available only  for acute toxicity or certain  efficacy

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             data and only if the cited study was conducted on my product, an identical product or
             a product which EPA has "grouped" with one or more other products for purposes of
             depending on the same data. I may also choose this option if I am citing my own
             data. In either case, I will provide the MRID or Accession Number(s) for the cited
             data on a "Product Specific Data Report"  form or in a  similar format. If I cite anoth
             registrant's data, I will submit a completed "Certification with Respect To Data
             Compensation Requirements" form.

      7.     I request a waiver for this study because it is inappropriate for my product (waiver
             Request). I am attaching a complete justification for mis request, including technical
             reasons, data and references to relevant EPA regulations, guidelines or policies.
             [Note: any supplemental data must be submitted in the  format required by P.R.
             Notice 86-5]. I understand that this is my  only opportunity to state the reasons or
             provide information in support of my request.  If the Agency approves my waiver
             request, I will not be required to supply the data pursuant to Section 3(c)(2)(B) of
             FIFRA. If the Agency denies my waiver request, I must choose a method of meetin
             the data requirements of this Notice by the due date stated by this Notice. In this
             case,  I must, within 30 days of my receipt of the Agency's written decision, submit a
             revised "Requirements Status and Registrant's Response" Form indicating the option
             chosen. I also understand that the deadline for submission of data as specified  by th
             original data call-in notice will not change.

Items 10-13  Self-explanatory.

NOTE:       You may provide additional information that does not fit on this form in a signed
             letter that accompanies this form. For example, you may wish  to report that your
             product has already been transferred to another company or that you have already
             voluntarily cancelled this product.  For these cases, please supply all relevant details
             so that EPA  can ensure that its records are correct.

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               ATTACHMENT D

EPA GROUPING OF END-USE PRODUCTS FOR MEETING
    DATA REQUREMENTS FOR REREGISTRATION

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  EPA'S DECISION NOT TO BATCH END-USE PRODUCTS CONTAINING IRON SALTS
    FOR PURPOSES OF MEETING ACUTE TOXICITY DATA REQUIREMENTS FOR
                                    REREGISTRATION


       In an effort to reduce the time, resources and number of animals needed to fulfill the acute
toxicity data requirements for reregistration of end-use products containing the active ingredient
iron salts, the Agency considered batching end-use products.  This process involves grouping simi
products for purposes of acute toxicity. Factors considered in the sorting process include each
product's active and inert ingredients (identity, percent composition and biological activity), type o
formulation (e.g., emulsifiable concentrate, aerosol, wettable powder, granular, etc.), and labeling
(e.g., signal word, use classification, precautionary labeling, etc.).

       Batching has been attempted using the readily available
information described above, and frequently acute toxicity data on individual end-use products has
been found to be incomplete.  Notwithstanding the batching process, the Agency reserves  the right
to require, at any time, acute toxicity data for an individual end-use product should the need arise.

       After consideration of the available information described above, batching of end-use
products containing iron salts was not possible.  The accompanying table lists all the end-use
products containing iron salts.  These products were either considered not to be similar for purpos
of acute toxicity or the Agency lacked sufficient information for decision making purposes.
Registrants of these products are responsible for meeting the acute toxicity data requirements for
each product.   Registrants must generate all the required acute lexicological studies for each of
their products.  If a registrant chooses to rely upon previously submitted acute toxicity data, he/sh
may do so provided that the data base is complete and valid by today's standards (see acceptance
criteria attached), the formulation tested is considered by the Agency to be similar for acute toxici
and the formulation has not been significantly altered since submission and acceptance of the acute
toxicity data. Regardless of whether new data is generated or existing data is referenced,  registran
must clearly identify  the test material by it's EPA Registration Number.

       In deciding how to meet the product specific data requirements, registrants must follow the
directions given in the Data Call-In Notice and its attachments appended to the RED. The DCI
Notice contains two response forms which are to be completed and submitted to the Agency within
90 days of receipt. The first form, "Data Call-In Response," asks whether the registrant will mee
the data requirements for each  product. The second form, "Requirements Status and Registrant's
Response," lists the product specific data required for each product, including the standard six acu
toxicity tests. A registrant must select one of the following options: Developing Data (Option 1),
Submitting an Existing Study (Option 4), Upgrading an Existing Study (Option 5) or Citing an
Existing Study (Option 6). Since the end-use products containing iron salts could not be batched,
registrants cannot choose from the  remaining options: Cost sharing (Option 2) or Offers to Cost
Share (Option 3).

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End-Use Products Containing Irons Salts (none were batched).
EPA Rg. No.
538-223
557-1838
802-504
802-509
802-543
802-558
3234-44
7001-290
7404-03
7404-04
7404-10
34704-713
64864-13
64864-14
% Active Ingredient
15.2% ferrous sulfate monohydrate
40.0% ferrous sulfate heptahydrate
4.78% ferrous sulfate heptahydrate
8.80% ferrous sulfate monohydrate
35.0% ferric sulfate
32.0% ferric sulfate monohydrate
95.4% ferrous sulfate monohydrate
32.5% ferrous sulfate monohydrate
15.0% ferrous sulfate monohydrate
25.38% ferrous sulfate monohydrate
17.05% ferrous sulfate monohydrate
39.85% ferrous sulfate monohydrate
65.0% ferrous sulfate heptahydrate
17.0% ferrous sulfate monohydrate
6.6% ferrous sulfate heptahydrate
Formulation Type
granular
granular
granular
soluble cone.
granular
granular
granular
granular
granular
granular
granular
soluble cone.
granular
soluble cone.

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     ATTACHMENT E



EPA ACCEPTANCE CRITERIA

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                                    SUBDIVISION D
Guideline           Study Title

Series 61           Product Identity and Composition
Series 62           Analysis and Certification of Product Ingredients
Series 63           Physical and Chemical Characteristics

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                                     61 Product Identity and Composition


                                          ACCEPTANCE CRITERIA


Does your study meet the following acceptance criteria?

1.	    Name of technical material tested (include product name and trade name, if appropriate).

2.	    Name,  nominal concentration, and certified  limits  (upper and lower) for each active  ingredient and e
          intentionally-added inert ingredient.

3.	    Name and upper certified limit for each impurity or each group of impurities present at >, 0.1 % by weight and
          for certain lexicologically significant impurities (e.g., dioxins, nitrosamines) present at <0.1 %.

4.	    Purpose of each active ingredient and each intentionally-added inert.

5.	    Chemical name from Chemical Abstracts index of Nomenclature and Chemical Abstracts Service (CAS) Regi
          Number for each active ingredient and, if available, for each intentionally-added inert.

6.	    Molecular, structural, and  empirical formulas, molecular weight or weight range, and any company assig
          experimental or internal code numbers for each active ingredient.

7.	    Description of each beginning material in the manufacturing process.
          	 EPA Registration Number if registered; for other beginning materials,       the     following:
          	 Name and address of manufacturer or supplier.
          	 Brand name, trade name or commercial designation.
          	 Technical specifications or data sheets by which manufacturer or supplier describes composition, proper
                or toxicity.

8.   . Description of manufacturing process.
          	 Statement of whether batch or continuous process.
          	 Relative amounts of beginning materials and order in which they are added.
          	 Description of equipment.
          	 Description of physical conditions (temperature, pressure, humidity) controlled in each step and the
                parameters that are maintained.
          	 Statement of whether process involves intended chemical reactions.
          	 Flow chart with chemical equations for each intended chemical reaction.
          	 Duration of each step of process.
          	 Description of purification procedures.
          	 Description of measures taken to assure quality of final product.

9.	    Discussion of formation of impurities based on established chemical theory addressing (1) each impurity wh
          may be present at >. 0.1 % or was found at >_ 0.1 % by product analyses and  (2) certain lexicologically signific
          impurities (see #3).

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                               62 Analysis and Certification of Product Ingredients


                                            ACCEPTANCE CRITERIA

The following criteria apply to the technical grade of the active ingredient being reregistered.  Use a table to present the
information in items 6, 7, and 8.

Does your study meet the following acceptance criteria?

 1.	  Five or more representative samples (batches in case of batch process) analyzed for each active ingredient and all
         impurities present at  >_ 0.1%.
 2.	  Degree of accountability or closure ^ ca 98%.
 3.	  Analyses conducted for certain trace toxic impurities at lower than 0.1 % (examples, nitrosamines in the case of
         products  containing  dinitroanilines or  containing secondary or  tertiary  amines/alkanolamines plus nitri
         polyhalogenated dibenzodioxins and dibenzofurans). [Note  that in the case of nitrosamines both fresh and sto
         samples must be analyzed.].
 4.	  Complete and detailed description of each step in analytical method used to analyze above samples.
 5.	  Statement of precision and accuracy of analytical method used to analyze above samples.
 6.	  Identities and quantities (including mean and standard deviation) provided for each analyzed ingredient.
 7.	  Upper and lower certified limits proposed for each  active ingredient and  intentionally added inert along w
         explanation of how the limits were determined.
 8.	  Upper certified limit proposed for each impurity present at J>. 0.1 % and for certain lexicologically signific
         impurities at <0.1 % along with explanation of how limit determined.
 9.	  Analytical methods to verify certified limits of each active ingredient and impurities (latter not required if exe
         from requirement of tolerance or if generally recognized as safe  by FDA) are fully described.
 10.	 Analytical methods (as discussed in #9) to verify certified limits  validated as to their precision and accuracy.

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                                    63 Physical and Chemical Characteristics

                                           ACCEPTANCE CRITERIA


 The following criteria apply to the technical grade of the active ingredient being reregistered.

 Does your study meet the following acceptance criteria?

 63-2 Color
    	  Verbal description of coloration (or lack of it)
    	  Any intentional coloration also reported in terms of Munsell color system

 63-3 Physical State
    	  Verbal description of physical state provided using terms such as "solid, granular, volatile liquid"
    	  Based on visual inspection at about 20-25 C

 63-4 Odor
    	  Verbal description of odor (or lack of it) using terms such as "garlic-like, characteristic of aromatic compoun

    	  Observed at room temperature
 63-5 Melting Point
    	  Reported in C
    	  Any observed decomposition reported

 63-6 Boiling Point
    	  Reported in C
    	  Pressure under which B.P. measured reported
    	  Any observed decomposition reported

 63-7 Density, Bulk Density, Specific Gravity
    	  Measured at about 20-25 C
    	  Density of technical  grade active ingredient reported in g/ml or the specific gravity of liquids reported w
           reference to water at 20 C. [Note: Bulk density of registered products may be reported in lbs/ft3 or Ibs/gallo

 63-8 Solubility
    	  Determined in distilled water and representative polar and non-polar solvents, including those used in fonnulat
           and analytical methods for the pesticide
    	  Measured at about 20-25 C
    	  Reported in g/100 ml (other units like ppm acceptable if sparingly soluble)

 63-9 Vapor Pressure
    	  Measured at 25 C (or calculated by extrapolation from measurements made at higher temperature if press
           too low to measure at 25 C)
    	  Experimental procedure described
    	  Reported in mm Hg (torr) or other conventional units

63-10 Dissociation Constant
    	  Experimental method described
    	  Temperature of measurement specified (preferably about
           20-25C)

63-11 Octanol/water Partition Coefficient
    	   Measured at about 20-25 C
    	   Experimentally determined and description of procedure provided (preferred method-45 Fed. Register 7735

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   	  Data supporting reported value provided

63-12 pH
   	  Measured at about 20-25 C
   	  Measured following dilution or dispersion in distilled water
63-13 Stability
    	   Sensitivity to metal ions and metal determined
    	   Stability at normal and elevated temperatures
    	   Sensitivity to sunlight determined

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                                              SUBDIVISION F
Guideline          Study Title

  81-1           Acute Oral Toxicity in the Rat
  81-2           Acute Dermal Toxicity in the Rat, Rabbit or Guinea Pig
  81-3           Acute Inhalation Toxicity in the Rat
  81-4           Primary Eye Irritation in the Rabbit
  81-5           Primary Dermal Irritation Study
  81-6           Dermal Sensitization in the Guinea Pig

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                                      81-1  Acute Oral Toxicity in the Rat


                                           ACCEPTANCE CRITERIA
Does your study meet the following acceptance criteria?

 1.	Identify material tested (technical, end-use product, etc).
 2.	At least 5 young adult rats/sex/group.
 3.	Dosing, single oral may be administered over 24 hrs.
 4.*	Vehicle control if other than water.
 5.	Doses tested, sufficient to determine a toxicity category or a limit dose (5000 mg/kg).
 6.	Individual observations at least once a day.
 7.	Observation period to last at least 14 days, or until all test animals appear normal whichever is longer.
 8.	Individual daily observations.
 9.	Individual body weights.
 10.	Gross necropsy on all animals.

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                          81-2 Acute Dermal toxicity in the Rat, Rabbit or Guinea Pig


                                           ACCEPTANCE CRITERIA
 Does your study meet the following acceptance criteria?

  1.	Identify material tested (technical, end-use product, etc).
  2.	At least 5 animals/sex/group.
  3.*	Rats 200-300 gin, rabbits 2.0-3.0 kg or guinea pigs 350-450 gm.
  4.	Dosing, single dermal.
  5.	Dosing duration at least 24 hours.
  6.+	Vehicle control, only if toxicity of vehicle is unknown.
  7.	Doses tested, sufficient to determine a toxicity category or a limit dose (2000 mg/kg).
  8.	Application site clipped or shaved at least 24 hours before dosing.
  9.	Application site at least 10% of body surface area.
 10.	  Application  site  covered with  a  porous nonirritating cover  to  retain  test  material  and  to  prev
         ingestion.
 11.	Individual observations at least once a day.
 12.	Observation period to last at least 14 days.
 13.	Individual body weights.
 14.	Gross necropsy on all animals.
Criteria marked with an * are supplemental and may not be required for every study.

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                                    81-3 Acute Inhalation Toxicity in the Rat


                                           ACCEPTANCE CRITERIA


Does your study meet the following acceptance criteria?

 1.	Identify material tested (technical, end-use product, etc).
 2.	Product is a gas, a solid which may produce a significant vapor hazard based on toxicity and expected use or
        contains particles of inhaiable size for man (aerodynamic diameter  15 urn or less).
 3.	At least 5 young adult rats/sex/group.
 4.	Dosing, at least 4 hours by inhalation.
 5.	Chamber air flow dynamic, at least 10 air changes/hour, at least 19% oxygen content.
 6.	Chamber temperature, 22 C (2"), relative humidity 40-60%.
 7.	Monitor rate of air flow.
 g.	Monitor actual concentrations of test material in breathing zone.
 9.	Monitor aerodynamic particle size for aerosols.
 10.	 Doses tested, sufficient to determine a toxicity category or a limit dose (5 mg/L actual concentration of respira
        substance).
 11.	 Individual observations at least once a day.
 12.	 Observation period to last at  least 14 days.
 13.	 Individual body weights.
 14.	 Gross necropsy on all animals.

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                                   81-4 Primary Eye Irritation in the Rabbit


                                           ACCEPTANCE CRITERIA
 Does your study meet the following acceptance criteria?

  1.	Identify material tested (technical, end-use product, etc).
  2.	Study not required if material is corrosive, causes severe
         dermal  irritation or has a pH of <2 or >_11.5.
  3.	6 adult rabbits.
  4.	Dosing, instillation into the conjunctiva! sac of one eye
         per animal.
  5.	Dose, 0.1 ml if a liquid; 0.1 ml or not more than 100 mg if a solid, paste or particulate substance.
  6.	Solid or granular test material ground to a fine dust.
  7.	Eyes not washed for at least 24 hours.
  8.	Eyes examined and graded for irritation before dosing and
         at 1, 24, 48 and 72 hr, then daily until eyes are normal
         or 21 days (whichever is shorter).
  9.*	Individual daily observations.
Criteria marked with an * are supplemental and may not be required for every study.

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                                     81-5 Primary Dermal Irritation Study

                                           ACCEPTANCE CRITERIA


Does your study meet the following acceptance criteria?

 1.	Identify material tested (technical, end-use product, etc).
 2.	Study not required if material is corrosive or has a pH of <2 or ^.11.5.
 3.	6 adult animals.
 4.	Dosing, single dermal.
 5.	Dosing duration 4 hours.
 6.	Application site shaved or clipped at least 24 hours prior to dosing.
 7.	Application site approximately 6 cm*.
 8.	Application site covered with a gauze patch held in place with nonirritating tape.
 9.	Material removed, washed with water, without trauma to application site.
 10.	 Application site examined and graded for irritation at  1, 24, 48 and 72 hr, then daily until normal or 14 d
        (whichever is shorter).
 11.*	 Individual daily observations.
 Criteria marked with an * are supplemental and may not be required for every study.

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                                  81-6  Dermal Sensitization in the Guinea Pig

                                           ACCEPTANCE CRITERIA
 Does your study meet the following acceptance criteria?

 1.	Identify material tested (technical, end-use product, etc).
 2.	Study not required if material is corrosive or has a
       pHof <.2or >_11.5.
 3.	One of the following methods is utilized:
       	Freund's complete adjuvant test
       	Guinea pig maximization test
       	Split adjuvant technique
       	Buehlertest
       	Open epicutaneous test
       	Mauer optimization test
       	Footpad technique in guinea pig.
 4.	Complete description of test.
 5.*	Reference for test.
 6.	Test followed essentially as described in reference document.
 7.	Positive control included (may provide historical data conducted within the last 6 months).
Criteria marked with an * are supplemental and may not be required for every study.

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                  ATTACHMENT F




LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE

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            ATTACHMENT G




COST SHARE AND DATA COMPENSATION FORMS

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    r/EPA
                         United  States Environmental Protection Agency
                                      Washington,  DC 20460
                            CERTIFICATION  OF OFFEft TO  COST
                          SHARE IN THE  DEVELOPMENT OF  DATA
Form Approved

OMB No. 2070-0106

Approval Expire*  12-31-92
 Public reporting burden for this collection of information is estimated to average 15 minutes per response includina
 time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed and
 completing and reviewing the collection of information.  Send comments regarding the burden estimate or any other
 aspect of this collection of information, including suggestions for reducing this burden, to Chief Information Policy
 Branch. PM-223. U.S. Environmental Protection Agency, 401 M St., S.W., Washington, DC 20460- and to the Office
 of Management and Budget, Paperwork Reduction Project (2070-0106), Washington, DC 20503.

 Please fill in blanks below.
  Company  Name
                                                                           Company Number
  Chemical Name
                                                                          EPA Chemical Number
 I  Certify that:

 My company is willing to develop and submit the data required by EPA under the authority of the Federal
 Insecticide, Fungicide and Rodenticide Act (FIFRA), if necessary.  However, my company would prefer to
 enter into an agreement with one or more registrants to develop jointly or share in the cost of developing
 data.

 My firm has offered in writing to enter into such an agreement.  That offer was irrevocable and included an
 offer to be bound by arbitration decision under section 3(c)(2)(B)(iii) of FIFRA if final agreement on all
 terms could not be reached otherwise.  This offer was made to the following firm(s) on the  following
 date(s):
  Name of Firm(s)
                                                                           Date of Offer
 Certification:
                                                                           Dale
I certify that I am duly authorized to represent the company named above, and that the statements that I have made on
t4 form and a **** therein are true, accurate, and ^^^^^Z      9y     "
misleading statement may be punishable by fine or imprisonment or both under apphcable law.

Signature  of Company's Authorized Representative
 Name and Title (Please Type or  Print)
EPA Form  8570-32

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    &EPA
United  States  Environmental Protection Agency
            Washington, DC  20460
   CERTIFICATION  WITH
 DATA  COMPENSATION
RESPECT  TO
REQUIREMENTS
Form Approved

OMB No.  2070-0106

Approval  Expires  12-31-9
 Public reporting burden for this collection of information is estimated to average 15 minutes per response, including
 time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and
 completing and reviewing the collection of information.  Send comments regarding the burden estimate or any other
 aspect of this collection of information, including suggestions for reducing this burden, to Chief, Information Policy
 Branch, PM-223. U.S. Environmental Protection Agency, 401 M St., S.W., Washington, DC 20460; and to the Office
 of Management and Budget, Paperwork Reduction Project (2070-0106), Washington, DC 20503.

 Please fill In blanks below.
Company Name
Chemical Name
Company Number
EPA Chemical Number
 I Certify that:

1.  For each study cited in support of registration or re registration under the Federal Insecticide, Fungicide and
    RodentickJe Act (FIFRA) that is an exclusive use study, I am the original data submitter, or I have obtained the
    written permission of the original data submitter to cite that study.

2.  That for each study cited in support of registration or reregistration under FIFRA that is NOT an exclusive use
    study. I am the original data submitter, or I have obtained the written permission of the original data submitter, or I
    have  notified in writing the company(ies) that submitted data I have cited and have offered to: (a)  Pay
    compensation for those data in accordance with sections 3(c)(1)(D) and 3(c)(2)(D) of FIFRA; and (b) Commence
    negotiation to determine which data are subject to the compensation requirement of FIFRA and the amount of
    compensation due, if any. The companies I have notified are: (check one)

    [ ]  All companies on the data submitters' list for the active ingredient listed on this form (Cite-All
        Method or Cite-All Option under the Selective Method). (Also sign the General Offer to Pay
        below.)

    [ ]  The companies who have submitted the studies  listed on the back of this form or attached
        sheets, or indicated on the attached "Requirements Status and Registrants' Response Form,"

3.  That I have previously complied with section 3(c)(1 )(D) of FIFRA for the studies I have cited in support of
    registration or reregistration under FIFRA.
Signature
Date
Name and Title (Please Type or Print)
GENERAL OFFER TO PAY: I hereby offer and agree to pay compensation to other persons, with regard to the
registration or reregistration of my products, to the extent required by FIFRA sections 3(c)(1)(D) and 3(c)(2)(D).
 Signature
                                                                          Date
 Name and Title (Please Type or Print)
EPA Form 8570-31 (4-90)

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 xv EPA
       United States Environmental Protection Agency
               Washington. DC 20460
Formulator's Exemption Statement
                (40 CFR 152.85)
Form Approved
OMD No. 2070-0060
Approval expires 9-30-90
Applicant's Name and Address
EPA File Symbol/Registration Number
Product Name
Date of Confidential Statement of Formula (EPA Form 8S70-4J
    As an authorized representative of the applicant for registration of the product
    identified above, I hereby certify that:

      (1) This product contains the following active ingredients):
      (2) Of these, each active ingredient listed in paragraph (4) is present solely as the
      result of the incorporation into the product (duringformulation or packaging) oi
      another product which contains that active ingredient, which is registered under
      FIFRA Section 3, and which is purchased by us from another producer.
      (3) Indicate by checking (A) or (B) below which paragraph applies:
      D (A) An accurate Confidential Statement of Formula (EPA Form 8570-4) for
         the above identified product is  attached to  this statement. That formula
         statement indicates, by company name, registration number, and product
         name, the source of the active ingredient(s) listed in paragraph (1).
                                        OR
      D (B) The Confidential Statement of Formula (CSF) (EPA Form 8570-4) refer-
         enced above and on file with the EPA is complete, current, and accurate and
         contains the information required on the current CSF.
    (4)  The following active ingredients in this product qualify for the formulator's
    exemption.
        Active Ingredient
                                                    Source
                                     Product Wanna
                                             Registration Number
Signature

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