GUIDANCE FOR THE
REREGISTHATICN OF PESTICIDE PRODUCTS
»
CONTAINING
' AHILAZIME
AS THE ACTIVE INGREDIENT
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20460
DECEMBER, 1983
-------
TABLE OF CONTENTS
Introduction 1
I. Regulatory Position 4
II. Requirement for Submission of Generic Data 13
III. Requirement for Submission of Product-Specific
Data . 49
IV. Submission of Revised Labeling and Packaging
Information. . , /.
- ftr""-" Label Contents •-•. ........ 50
1. Product Name 50
2. Company Name and Address - ... 50
3. Net Contents 50
4. Product Registration Number . . 51
5. Producing Establishment
Registration Number 51 ';
6A Ingredient Statement 51
6B Pounds Per Gallon Statement 51
7. Front Panel Precautionary Statements ...... 51
7A Child Hazard Warning Statements '. 52
7B Signal Word. ....'.. 52
7C Skull and Crossbones and Word Poison 52
7D Statement of Practical Treatment ........ 52
7E Referral Statement 52
8* Side/Back Panel Precautionary Labeling ..... 52
8A Hazard to Humans and Domestic Animals. ..... 53
8B Environmental Hazard .53
8C Physical or Chemical Hazard. . 53
9 Misuse Statement 54
10A Storage and Disposal Block ..... 54
10B Directions for Use * 54
B. Collateral Information 54
V. Instructions for Submission 55
-------
APPENDICES
II-l Bibliography
II-2 FIFRA §3(c}(2)(3) Summary Sheet - SPA Form 3530-1.
II-3 Certification of Attempt to Enter Into an Agreement
With Other Registrants for Development of 'Data
EPA Form 3530-6
III-l Product Specific Data Report (End-Use Products)
EPA Form 8530-4
/
IV-1 . ._,-40 ,CFR §162.10 Labeling Requirements,,
IV-2 Table of.. Labeling Requirements and Sample Labels
IV-3 Physical/Chemical Hazards Labeling Statement
IV-5 Storage and Disposal Statements
Mote: Appendices IV-4 and IV-6 are not germane to this
document and are not included.
-------
INTRODUCTION
The Federal Insecticide, Fungicide, and Rodenticide Act,
(FIFRA Sec-ion 3(g), as amended in 1978, directs SPA to
reregister all pesticides as expeditiously as possible.
Each registrant of a manufacturing use product of the active
ingredient who wishes to continue to sell or distribute that
product must apply for reregistration.
To fulfill this Congressional mandate, we have established
the Registration Standards program which will review all pesti-
cide active ingredients first registered before January 1,
1977. These pesticides will be reviewed in use clusters
which are prioritized on tHe basis of a ranking scheme giving
preference—to pesticides used on food and feed crops.
The Registration , Standards program involves a thorough
review of the scientific data base underlying pesticide
registrations and an identification of essential but missing
studies which may not, have been required when the. product
was initially registered or studies that are now considered
insufficient. Our reassessment results in the development
of a regulatory position, contained in this document, on
each pesticide and its uses. The regulatory position may
require the registrant to modify product 'labels to provide
additional precautionary statements, restrict the use of the
pesticide to certified applicators, provide reentry intervals;
modify uses or formulation types, specify certain packaging
limitations, or other requirements to assure that proper use
of the pesticide poses no potential adverse effects to human
health or the environment.
The scientific review, which is not contained herein
but is available upon request, concentrates on the technical
grade of the active ingredient and identifies missing generic
data. However, during the review of these data we are also
looking for potential hazards that may be associated with
the formulated (end-use) products that contain the active
ingredient. If we find serious concerns, we will bring
formulated products under the provisions of the Registration
Standards program to the extent necessary to protect the
public.
EPA has the authority under FIFRA §3(c)(2)(3) to require
that certain registrants submit generic data that will answer
our questions regarding the hazard that may result from the
intended use of the .pesticide under review. Further, §3(c)
(2)(3) provides that these data are to be submitted by
those registrants who do not qualify for the formulator's
exemption [FIFRA §3(c)(2)(D)]. Normally, this means that
the registrants who are responsible for filling the data
gaps are the manufacturing-use product producers (basic
-------
suppliers of the active ingredient). However, end-use producers
will not qualify for the formuiator's exemption if the source
of their active ingredient: (1) is not registered with SPA,
and/or (2) is produced by the registrant's firm, or a firm
which has ownership in common with the registrant's firm.
These end-use producers can qualify for the formuiator's
exemption if they change their source of supply to a registered
source, provided the source does not share ownership in
common with the registrant's firm. If the end-use product
registrant decides to switch sources, a new Confidential
Statement of Formula, EPA Form 8570-4, must be submitted to
the appropriate Product Manager within 90 days of receipt of
this Guidance Document. The chart on the following page
shows what is generally required of those who do and do not
qualify_..f-or the formuiator's exemption in the -Registration
Standards program. ^
If you decide to request the Agency to discontinue the
registration of any of your products subject to the reregistra-
tion requirements of this Guidance Document, please notify
the Product Manager named in the cover letter, within 90
days from the receipt of this document, that you wish to
voluntarily cancel the registration(s). If you decide to
maintain your product registration(s), you must provide the
information described in the following pages within .the time-
frames outlined. EPA will issue a notice of intent to cancel •
or suspend the registration of any currently registered
product if you fail to comply with the requirements set
forth in this Guidance Document.
This Guidance Document will be supplemented by EPA with
additional information about compliance with data support
requirements. In Monsanto v. Administrator, EPA was recently
enjoined from implementingin any way the^mandatory data
licensing" aspects of §3(c)(l)(D) of FIFRA. EPA is assessing
the implications of the injunction for the reregistration
process, Because this situation is currently unresolved, EPA
has decided to proceed with the requirements in this Guidance
Document which do not relate to compliance with the §3(c)(l)(D)
provisions and to supplement the Document with additional
guidance when circumstances permit. Failure to comply with
the provisions of the subsequent guidance will also result
in issuance by EPA of an intent to cancel the affected product
registration!s).
Registrants are reminded that §6(a)(2) of FIFRA requires
you at any time to submit factual information raising concerns
of possible unreasonable adverse effects of a pesticide. You
should notify the Agency of interim results, of studies in
progress if those results .show possible adverse effects.
-------
PRODUCTS SUBJECT TO THE
REGISTRATION STANDARDS PROGRAM
ACTION(S) REQUIRED TO
MAINTAIN REGISTRATION
I. Products That Do Not Qualify
For The Pormulator's Exemption
A. Single Active Ingredient
Products*
These products must be
tered. To obtain reregistration,
labeling, packaging and data
requirements must be satisfied
in accordance with the Regis-
tration Standards Guidance
Document.
B. Multiple Active Ingredient
Products
These products will not be
reregistered at this time.'
However, generic data required
to continue the registration of
the active ingredient under
review, as described in the
Registration Standards Guidance
Document, will be required and
some labeling precautions may _
also be required.
II. Products That Do Qualify For
The Formulator's Exemption
Only when additional restric-
tions or labeling are needed to
protect man or -the environment
will these products be subject
to the Registration Standard
requirements* Affected products
will be dealt with in a variety
of ways, including but not
limited to the Label Improvement
Program and special intent
I * I to cancel notices .
i, _ ! _ ; _
I* End-use products of registrants who also produce a manuf acturing-
I use product will not be required to be reregistered provided that
[registrant fulfills the requirements specified in the Guidance
! Document for manufacturing-use product(s). Such end-use products
[will be
[above.
- . -
subject to the labeling changes required for products in "11
If there are no manufacturing-use products registered by any
[company end-use products will be required to be reregistered.
NOTE: If all registrants in "I" above fail to meet the requirements in
I-A and B above, then the registrants in "II" lose their right to
qualify for the formulator's exemption and become subject to the
requirements in I-A and B. _
-------
I. REGULATORY POSITION AND RATIONALE
A. Introduction
This Registration Standard describes the regulatory position of the
Environmental Protection Agency (EPA or the Agency) on registration of
manufacturing-use products (MP) containing the fungicide anilazine. The
Agency's position is based on a consideration of available data and on an
evaluation of all registered uses and registered MPs with anilazine as an
active ingredient.
This position is based on a number of considerations. Foremost
among these is an analysis of anilazine data based on the risk criteria
found in Section 162.11(a) of Title 40 of the U.S. Code of Federal
Regulations. The Standard also considers labeling requirements, tolerances,
"Special Local Needs" registrations authorized by Section 24(c) of the
FIFRA as well as Federal registrations granted under Section 3 of the
FIFRA. Finally, the Agency sets forth the data requirements that must be
met to register or reregister products covered by the Standard.
This Standard only addresses registration requirements for current
or substantially similar future MPs and their intermediaries. Anilazine
MPs that differ appreciably from those described here may require amendments
to the Standard. Additionally, use patterns which differ from those
described here may also require amendments to the Standard.
B. Description of Chemical
Anilazine is the acceptable common name for 2,4-dichloro-6-(0-
chloroanilino)-s_-triazine recognized by the British Standards Institution
and the International Standardization Organization. Trade names and other
-------
names for anilazine are: Dyrene, Direz, Kemate, Triasyn, B-622, Ent-26,058,
HC1-C08684, and 4,6-dichloro-N-(2-chlorophenyl)-l,3,5-triazin-2-amine.
The Chemical Abstracts Service (CAS) Registry Number is 101-05-3. The
OPP Internal Control Number (EPA Shaughnessy Number) is 080811. The
C!
structural formula is:
,N
H
c'i
Anilazine is a white to tan crystalline solid that is practically non-
volatile. The empirical formula is CgH^C^N^ The melting point of
anilazine is 159-160°C. It is insoluble in water, but is soluble in
chlorobenzene, toluene, xylene and acetone.
Anilazine was developed by Ethyl Corporation and Pittsburgh Coke and
Chemical Company. It is manufactured by Mobay Chemical Corporation under
license from Ethyl Corporation, owner of the patent rights.
C. Use Profile
Anilazine is a protectant foliar fungicide registered to control a
number of fungal plant pathogens on turf, tobacco, ornamentals and various
fruits and vegetables. Approximately 80% of the anilazine produced is used
on turf, tomatoes and celery. The compound is also registered as a
fungicidal additive to vinyl plastics.
At present there are 33 formulated products, 2 technical products
and 2 formulating intermediates federally registered containing anilazine
as a single active ingredient. Three additional multiple active ingredient
products containing anilazine are registered. In addition to the federal
registrations, 5 intrastate products and 2 "Special Local Needs" are
-------
registered.
D. Regulatory Position
Based on a scientific and technical evaluation of the available data
and other relevant information on the chemical, the Agency has made the
following determinations regarding anilazine:
1. Manufacturing-use pesticide products containing anilazi'ne as a sole
active ingredient or mixed with other active ingredients may be registered
for sale, distribution and use subject to the terms and conditions
specified in this Standard.
2. Because of the extensive data gaps for anilazine, the Agency is not
able to evaluate all of the hazards that are routinely evaluated.
However, based on the available data, anilazine has not been demonstrated
to cause unreasonable adverse effects in man when used in accordance
with prescribed label directions and precautions.
3. A review of available studies has identified potential environmental
concerns. Results of these studies indicate a very high acute toxicity to
fish and aquatic invertebrates.
Anilazine is federally registered for use on cranberries in Wisconsin
only. This cranberry acreage is in close proximity to aquatic environments
The potential exists for aquatic species to be adversely affected-via
release of water containing anilazine into the aquatic environment,
drift or inadvertant direct application. Due to a lack of environmental
fate data, it is not possible to estimate tha hazard to non-
target organisms. Once the Agency has evaluated these additional
data, it will determine if continued registration of products containing
-------
anilazine for use on cranberries is warranted or whether additional
restrictions are needed.
4. Registrants must agree to develop or provide additional data, as
specified in Tables A and B located in Chapter IV of this document, in
order to maintain existing registrations or to permit new anilazine
registrations.
5. Tolerance reassessment is normally a part of the Registration Standard
review process. Due to the absence of pertinent data, the Agency
is unable to complete its reassessment of anilazine tolerances. Specifically,
the Agency is unable to establish a valid "No Observed Effect Level" (NOEL)
or determine an "Acceptable Daily Intake" (ADI) for anilazine.
The Agency will complete its tolerance assessment when the data gaps have '
been satisfied.
Summary of present tolerances for anilazine (in parts per million):
Canada Mexico Codex U.S.
Blackberries
Blueberries
Celery
Cranberries
Cucumbers, inc pickles
Dewberries
Garlic
Onions, dry bulb
Onions, green
Potatoes
5.0
10.0
10.0
10.0
5.0
10.0
10.0
10.0
10.0
1.0
10.0
10.0
10.0
10.0
10.0
10.0
1.0
1.0
10.0
1.0
-------
Loganberries 5.0 - - 10.0
Melons 5.0 - - 10.0
Pumpkin, inc squash 5.0 - - 10.0
Raspberries 5.0 - - 10.0
Shallots 10.0 - - 10.0
Summer squash 5.0 - - 10.0
Strawberries-. 20.0 - - 10.0
Tomatoes 10.0 - - 10.0
Winter squash 5.0 - - 10.0
E. Regulatory Rationale
/'The Agency has determined that it can allow the registration of
anilazine after considering the following:"
1. Anilazine is degraded rapidly in both moist and dry soils under
aerobic conditions!] with half-lives of 0.5 and 2.5 days, respectively.
j^
Anilazine is moderately mobile in sandy loam soil, but slightly mobile in
agricultural sand, sandy clay loam, silt loam, and silty clay soils.
2. There is sufficient information to characterize anilazine as practically
u~
non-toxic to birds and honey bees^ I This chemical has been found to be
highly toxic to fish and aquatic invertebrates. Strict adherence to
application techniques as prescribed in the label directions and
precautions will minimize the risk of potential adverse effects to aquatic
organisms.
^-" -— ^
\ 3, Acute oral studies reviewed show anilazine to be a low risk chemical \ \
C..-. ' "
The studies submitted placed anilazine in Category II (rabbit), III (rat)
and IV (dog). An acute dermal study on the rabbit placed the chemical in
8
-------
Category III for dermal effects. However, the Agency considers anilazine
to be a skin sensitizer. Strict adherence to application techniques and
precautionary statements as outlined on the label will minimize
exposure.
*• There are currently no data available to establish safe reentry
intervals for anilazine-treated areas, thus no reentry intervals have
""""" ' "^1 "
been established. \ Since dermal exposure to anilazine has been shown
to result in skin irritations, reentry data are needed to establish safe
reentry intervals. Until such data have been developed and evaluated,
an interim 24 hour reentry interval is required.
5. It is not the Agency's policy to cancel or to withhold registration
•v
merely because data are missing or inadequate [see FIFRA Sections 3(c)(2)(B)
and 3(c)(7)], Rather, publication of this Standard provides a mechanism
for identifying data needs, and registration of anilazine under this
Standard allows for the upgrading of labels during the period in which the
required data are being developed. These data will be reviewed and
evaluated when they are received and the Agency will determine, at that
time, whether they will affect the registrations of anilazine.
F. Criteria for Registration Under This Standard
To be covered by this Standard, products must contain anilazine as
the sole active ingredient or in combination with other active ingredients,
bear required labeling, and conform to the product composition, acute
toxicity limits, and use pattern requirements listed in Section G of
this document.
The applicant for registration or reregistration of products subject
-------
to this Standard must comply with all terms and conditions described in
it. That includes making a commitment to fill data gaps on a schedule
agreed to by both this Agency and the applicant. Applicants for registration
under this Standard must follow the instructions contained in this guidance
package and complete and submit the appropriate forms within the time specified.
G. Acceptable Ranges and Limits
1. Product Composition
To be covered under this Standard, technical grade products must
contain at least 92 percent anilazine as the sole active ingredient.
Each MP formulation proposed for registration must be fully described
with appropriate certification of limits.
2. Acute Toxicity Limits
The Agency will consider registration of technical grade products and
HP's containing anilazine for any acute toxicity category, provided
the labeling of those products bear appropriate precautionary
statements.
3. Use Patterns
To be registered under this Standard, HP's containing anilazine may be
labeled for formulation only into end-use products for:
0 Terrestrial, food crops on: tomatoes, celery, blackberries, dew-
berries, loganberries, raspberries, strawberries, blueberries,
huckleberries, cucumbers, onions (green and bulb or dry), garlic
10
-------
shallots, potatoes, pumpkins, squash, melons and cranberries
(Wi s cons in only).
Terrestrial, non-food crops on: tobacco
Domestic, outdoor on: gladioli, lawns and turf (bluegrasses, bent
grasses, rye grasses and fescues).
H. Required Labeling
All technical grade and MP products containing anilazine
must bear appropriate labeling as specified in 40 CFR 162.10. Other
portions of the guidance package contain specific information regarding
label requirements.
1. Manufacturing-Use
\
In addition to the labeling as described above, the labels of all
HP's must contain the following statements:
0 "For formulation into end-use fungicide products intended for
domestic and non-domestic outdoor terrestrial use on (crops
to be specified)."
0 "This pesticide is toxic to fish and aquatic invertebrates. Do
not discharge into lakes, streams, ponds or public water unless
in accordance with an NPDES permit. For guidance, contact your
Regional Office of EPA."
0 "Protective clothing should be worn during periods of exposure,
such as, during application or when contacting treated foliage."
2. End-Use Products
The following labeling recommendations are being made at this time
11
-------
based on current use patterns and based on review of available data.
Additional labeling statements may be needed upon receipt and
evaluation of the data requested in this Standard.
All sites (except cranberries)-
0 "This pesticide is toxic to fish and aquatic invertebrates.
Do not apply directly to water or wetlands. Drift and runoff
from treated areas may be hazardous to aquatic organisms in
neighboring areas. Do not contaminate water by cleaning of
equipment or disposal of wastes. Cover or incorporate spills."
Cranberries only—
0 "This pesticide is toxic to fish and aquatic invertebrates.
Movement from treated areas may be hazardous to aquatic
organisms in neighboring areas. Do not contaminate water
by cleaning of equipment or disposal of wastes. Cover
and incorporate all spills."
All sites -
0 "Do not use on seed crops intended to be used for feed or
forage. Do not graze treated areas."
0 "Do not reenter treated fields within 24 hours following
application of this product."
0 "Protective clothing should be worn during periods of
exposure, such as during application or when contacting
treated foliage."
12
-------
EPA Index Co Pesticide Chemicals
C080811 2,4-DtCHLORO-6-(0-CHLOROANILO)-S-TRLAZINE*
TYPE PESTICIDE: Fungicide
FORMULATIONS; Tech (92%, 95%); FI (50%, 80%); D (5%); G (3%, 3.9%,
4.45%, 5%, 8.6%, 8.7%); WP (25%, 33.33%, 50%)
+ GENERAL WARNINGS AND LIMITATIONS: None.
Site and Pest
Dosages and Tolerance, Use, Limitations
Fonnulation(s)
/0100200
(JJFIBFBAW
$0100201
&005.0003
&05Q.0006
(3FMAMSBL
$0100201
&005.0006
&050.00Q6
§FJACXAH
50100201
i005.0003
i050.0006
AGRICULTURAL CROPS
General Warnings and Limitations: Complete and thorough coverage of fol-
iage is necessary for satisfactory control. Start applications before
disease appears and repeat treatment as needed, usually at 7 to 10 day
intervals. During wet weather, applications of 4 to 5 day intervals may
be advisable. Applications should be made throughout the growing season
and scheduled with local conditions. For specific use information, con-
sult the State Agricultural Cooperative Extension Service. Do not use on
seed crops intended to be used for feed or forage. Do not graze treated
areas
Blackberry
Botrytis fruit rot
10 ppm
14 day preharvest interval through
3.0 pounds per acre.
1.5-3.0 Ib/A Foliar application.
(5% D)
1.0-2.0 Ib/A Foliar application. Apply using
(50% WP) 100 to 200 gallons of water per
acre.
Cane and leaf spot (Septoria)
1.5-3.0 Ib/A Foliar application.
(5% D)
1.0-2.0 Ib/A Foliar application. Apply using
(50% WP) 100 to 200 gallons of water.
Yellow rust/Cane rust (Kuehneola)
1.5-3.0 Ib/A Foliar application.
(5% D)
1.0-2.0 Ib/A Foliar application. Apply using
(50% WP) 100 to 200 gallons of water per
acre.
*4,6-dichloro-N-(2-chlorophenyl)-l,3,5-triazin-2-aiaine
Dyrene
Issued: 4-07-79
II-080811-1
-------
SPA Index to Pesticide Chemicals
@FFABPEA
PFAAACDP
(3FBAQMCO
PFAAACDP
(3FMBCAAX
PFAAACDP
(3FMBCCBM
PFAAACDP
/0101000
(3FMAWPCE
$0101001
&050.0006
(9FIBFCBV
PFMAWPCE
(3FIBCGAV
PFMAWPCE
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIAZINE
Site and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
Cucumber (continued)
Downy mildew (Pseudoperonospora)
Foliar application.
Refer to Anthracnose (Colletotrichum) for use and
limitation information.
Gummy stem blight (Mycosphaerella)
Foliar application.
Refer to Anthracnose (Colletotrichum) for use and
limitation information.
Leaf spot (Altemaria)
Foliar application.
Refer to Anthracnose (Colletotrichum) for use and
limitation information.
Leaf spot (Cercospora)
Foliar application.
Cranberry
Refer to Anthracnose (Colletotrichum) for use and
limitation information.
10 ppm
14 day pr^harvest interval through
3.0 pounds per acre.
Use limited to WI.
Berry sr^t (Phyllosticta)
3.0 Ib/A
(50% WP)
Black rot (Ceuthospora)
Foliar application. Apply using
300 gallons of water per acre.
Foliar application.
End rot (Godronia)
Refer to Berry spot (Phyllosticta) for use and
limitation information.-
Foliar application.
Refer to Berry spot (Phyllosticta) for use and
limitation information.
Issued: 4-07-79
II-080811-3
-------
Site and Pest
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIAZINE
Dosages and Tolerance, Use, Limitations
FormulationCs)
/0101500
(3FMBCDCF
40101501
S0100901
Huckleberry
Double spot (Dothichiza)
10 ppm
14 day preharvest interval through
1.5 pounds per acre.
Foliar application.
Refer to Blueberry, Double spot (Dothichiza),
Foliar application for use and limitation infor-
mation.
(3FMBCSBL
40101501
S0100901
/.0100500
Leaf spot (Septoria)
Loganberry
Foliar application.
Refer to Blueberry, Leaf spot (Septoria), Foliar
application for use and limitation information.
10 ppm
14 day preharvest interval through
3.0 pounds per acre.
(3FIBFBAW
40100500
S0100201
(3FMAMSBL
40100501
S0100201
Botrytis fruit rot
Foliar application.
Refer to Blackberry, Botrytis fruit rot, Foliar
application for use and limitation information.
Cane and leaf spot (Septoria)
Foliar application.
Refer to Blackberry, Cane and leaf spot (Septor-
ia), Foliar application for use and limitation
information.
(3FJACKAH
40100501
S0100201
Yellow rust/Cane rust (Kuehneola)
Foliar application.
Refer to Blackberry, Yellow rust/Cane rust (Kueh-
neola), Foliar application for use limitation and
information.
Issued: 4-07-79
II-080811-5
-------
0FCAEAAX
$1401101
S1400701
/1600400
(3FHACBAW
$1600401
&005.0003
&050.0006
(3FCAEAAX
PFHACBAW
/1401300
(3FBAMAAX
$1401301
&005.0003
&050.0006
(3FBASPCN
PF3AMAAX
Site and Past
EPA Index Co Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIAZINE
Dosages and Tolerance, Use, Limitations
Formulation(s)
Onion (bulb, dry) (continued)
Purple blotch (Alternaria)
Foliar application.
Onion (green)
Refer to Garlic, Purple blotch (Botrytis), Foliar
application for use and limitation information.
10 ppm
No preharvest interval^indicated
through 2.0 pounds per acre.
Not recommended'--for use in FL«
Gray mold (Botrytis)
1.0-2.0 Ib/A Foliar application.
(5% D)
1-0-1.5 Ib/A Foliar application. Apply using 75
(50% WP) to 100 gallons of water per acre.
Purple blotch (Altemaria)
Foliar application.
Potato
Refer to Gray mold (Botrytis) for use and limita-
tion information.
1 ppm
No preharvest interval indicated
through 2.5 pounds per acre.
Early blight (Altemaria)
1.0-2.0 Ib/A Foliar application.
(5% D)
1.0-2.5 Ib/A Foliar application. Apply using 75
(50% WP) to 175 gallons of water per acre.
Late blight (Phytophthora)
Foliar application.
Refer to Early blight (Altemaria) for use and
limitation information.
Issued: 4-07-79
II-080811-7
-------
(3FMAMSBL
$0100601
S0100201
(9FJACKAH
$0100601
S0100201
/1401700
(3FHACBAW
$1401701
SI600401
(3FCAEAAX
$1401701
S1600401
/1001200
(3FAAACDP
$1001201
S1001001
SPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILQ)-S-TRIAZ!NE
Site and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
Raspberry (continued)
Cane and leaf spot
Foliar application.
Refer to Blackberry, Cane and leaf spot, Foliar
application for use and limitation information.
Yellow rust/Cane rust (Kuehneola)
Foliar application.
Shallot
Refer to Blackberry, Yellow ru-st/Cane rust (Kueh-
neola), Foliar application for use and limitation
information.
10 ppra
No preharvest interval indicated
through 2.0 pounds per acre.
Not recommended for use in FL.
Gray mold (Botrytis)
Foliar application.
Refer to Onion (green), Gray mold (Botrytis),
Foliar application for use and limitation infor-
mation.
Purple blotch (Alternaria)
Foliar application.
Squash
Refer to Onion (green), Gray mold (Botrytis),
Foliar application for use and limitation infor-
mation.
10 ppra
No preharvest interval indicated
through 3.0 pounds per acre.
Anthracnose (Colletotrichum)
Foliar application.
Refer to Cucumber, Anthracnose (Colletotrichum},
Foliar application for use and limitation infor-
mation.
Issued: 4-07-79
II-080811-9
-------
(3FMBCMCO
PFHACBAW
/2600300
(3FMAJAAX
$2600301
&050.0006
/1100500
(3FAAAGAP
$1100501
&005.0003
&Q50.0006
(3FBAMAAX
PFAAAGAP
(3FMAXSDG
PFAAAGAP
(3FHACBAW
PFAAAGAP
(3FBASPCN
PFAAAGAP
Site and Pest
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIAZINE
Dosages and Tolerance, Use, Limitations
Formulation(s)
Strawberry (continued)
Leaf spot (Mycosphaerella)
Foliar application.
Refer to Gray mold (Botrytis) for use and limita-
tion information.
Tobacco
Brown spot (Alternaria)
1.0 lb'/A
(50% WP)
Tomato
Foliar application. Apply using
100 gallons of water per acre.
Apply at weekly intervals during
harvest, after each priming=
10 ppra
No preharvest interval indicated
through 2.5 pounds per acre.
Anthracnose (Glomerella)
1.0-1.5 Ib/A Foliar application.
(5% D)
1.0-2.5 Ib/A Foliar application. Apply using 75
(50% WP) to 175 gallons of water per acre.
Early blight (Alternaria)
Foliar application
Refer to Anthracnose (Glomerella) for use and
limitation information.
Gray leaf spot (Stemphylium)
Foliar application.
Refer to Anthracnose (Glomerella) for use and
limitation information.
Gray mold (Botrytis)
Foliar application.
Refer to Anthracnose (Gloraerella) for use and
limitation information.
Late blight (Phytophthora)
Foliar application.
Refer to Anthracnose (Glomerella) for use and
limitation information.
Issued: 4-07-79
11-080811-11
-------
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIAZINE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Bentgrass (continued)
Leaf spot (Helminthosporiura) (continued)
0.12-0.3 lb/ Foliar application. For a preven-
1,000 sq.ft tive program where disease has not
&005.0004 (5% G) been a problem, use the lower rate.
Where disease has been a problem,
apply 0.2 pound per 1,000 square.
feet. For curative treatment, apply
at the higher rate in the. late
spring to early summer and continue
at 10 to 14 day intervals to early
fall.
0.13-0.2 lb/ Foliar application. For a preven-
1,000 sq.ft tive program, apply the lower rate
&005.0004 (5% G) in the spring before disease is
present. Repeat applications at 10
to 14 day intervals. During peri-
ods of wet weather, apply at 7 day
intervals. Continue applications
throughout spring and summer. For
curative treatment, use the higher
rate. Do not mow or water lawn for
24 hours after treating.
0.12-0.25 lb/ Foliar application. Apply in 5
1,000 sq.ft gallons of water per 1,000 square
&050.0006 (50% WP) feet. Repeat at 1 to 2 week inter-
vals throughout the spring and sum-
mer months.
0.13-0.25 lb/ Foliar application. Apply with
1,000 sq.ft garden hose sprayer or mix with 2.5
&050.0006 (50% WP) gallons of water and apply with a
compressed air sprayer. Use 0.13
pound for disease prevention and
0.19 pound for spot treatment of
diseased areas. If using a field
sprayer, mix 0.13 to 0.25 pound in
5 gallons of water and apply.
Begin applying in spring before
disease appears and repeat at 10 to
14 day intervals. During periods
of wet weather apply at 7 day in-
tervals. Continue treating through-
out spring and summer. If neces-
sary, water lawn before treating=
Issued: 4-07-79 11-080811-13
-------
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANiro)-S-TRIAZINE
Site and Pest
Dosages and Tolerance> Use, Limitations
Formulation(s)
Bentgrass (continued)
Red leaf spot (continued)
&050.0006
0.13-0.25 lb/ Foliar application. Apply with
1,000 sq.ft garden hose sprayer or mix with 2.5
(50% WP)
gallons of water and apply with a
compressed air sprayer. Use 0.13
pound for disease prevention and
0.19 pound for spot treatment of
diseased areas.. If using a field
sprayer, mix 0.13 to 0.25 pound in
5 gallons of water and apply.
Begin applying in spring before
disease appears and repeat at 10 to
14 day intervals. During periods
of wet weather apply at 7 day in-
tervals. Continue treating through-
out spring and summer. If neces-
sary j water lawn before treating.
(3FMBYHAM
$3301601
&005.0004
Zonate eye spot (Helminthosporium)
0.12-0.3 lb/
1,000 sq.ft
(5% G)
Foliar application. For a preven-
tive program where disease has not
been a problem, use the lower rate.
Where disease has been a problem,
apply 0.2 pound per 1,000 square
feet. For curative treatment,
apply at the higher rate in the
late spring to early summer and
continue at 10 to 14 day intervals
to early fall.
0.13-0.2 lb/ Foliar application. For a preven-
1,000 sq.ft tive program, apply the lower rate
&005.0004
(5% G)
in the spring before disease is
present. Repeat applications at 10
to 14 day intervals. During peri-
ods of wet weather, apply at 7 day
intervals. Continue applications
throughout spring and summer. Fojr
curative treatment use the higher
rate. Do not mow or water lawn for
24 hours after treating.
Issued: 4-07-79
11-080811-15
-------
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANIL'0)-S-TRIA2INE
i
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Bermudagrass (continued)
Leaf blotch (Helminthosporiura) (continued)
0.13-0.25 lb/ Foliar application. Apply with
1,000 sq.ft garden hose sprayer or mix with 2.5
&050.0006 (50% WP) gallons of water and apply with a
compressed air sprayer. Use 0.13
pound for disease prevention and
0.19 pound for spot- treatment of
diseased areas.. If usTrig a field
sprayer, mix 0.13 to 0.25 pound in
5 gallons of water and apply.
Begin applying in spring before
disease appears and repeat at 10 to
14 day intervals. During periods
of wet weather, apply at 7 day
intervals. Continue treating
throughout spring and summer. If
necessary, water lawn before treat-
ing.
/3301900 Bluegrass
(3FMAQSAQ Dollar spot (Sclerotinia)
$3301901 Foliar application.
S3301601 , Refer to Bentgrass, Dollar spot (Sclerotinia),
Foliar application for use and limitation infor-
mation.
(9FMBCHAM Leaf spot (Helminthosporium)
$3301901 . Foliar application.
S3301601 Refer to Bentgrass, Leaf spot (Helminthosporium),
Foliar application for use and limitation infor-
mation.
(3FMBYHAM Zonate eye spot (Helminthosporium)
$3301901 Foliar applications.
S3301601 Refer to Bentgrass, Zonate eye spot (Helmintho-
sporium), Foliar application for use and limita-
tion information.
Issued: 4-07-79 11-080811-17
-------
EPA Index Co Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIA2INE
Site and Pest
Dosages and Tolerance, Use, Limitations
Forraulation(s)
Fescue (continued)
Helminthosporium blight (continued)
&050.0006
•0.13-0.25 lb/ Foliar application. Apply with
1,000 sq-ft garden hose sprayer or mix with 2.5
(50% WP)
gallons of water and apply with a
compressed air sprayer. Use 0.13
pound for spot treatment of
diseased areas. If using a field
sprayer, mix 0.13 to 0.25 pound in
5 gallons of water and apply.
Begin applying in spring before
disease appears and repeat at 10 to
14 day intervals. During periods
of wet weather, apply at 7 day
intervals. Continue treating
throughout spring and summer. If
necessary, water lawn before
treating.
(3FMBCHAM
$3303101
S3301601
Leaf spot (Helminthosporium)
Foliar application.
Refer to Bentgrass, Leaf spot (Helminthosporium),
Foliar application for use and limitation
information.
fFMBYHAM
$3303101
PFBAAHAM
/3303400
!§FBATHAM
$3303401
F
&004.0004
Zonate eye spot (Helminthosporium)
Foliar application.
Refer to Helminthosporium blight for use and
limitation information.
Kentucky Bluegrass
Melting out (Helminthosporium)
0.16-0.24 lb/ Foliar application. Use lower rate
-1,000 sq.ft for preventive treatment. Begin
(4% G) applying from early spring to early
summer, repeating at 10 to 14 day-
intervals as long as cool, wet
weather persists. For curative
treatment apply at the higher rate
at 10 day intervals until
improvement is noted.
Formulated with maneb.*
*Contains 0.1 percent zinc as
metallic.
Issued: 4-07-79
11-080811-19
-------
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIAZINE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
3300800 Ornamental Turf
rBAHRAM Brown patch (Rhizoctonia)
3300801 0.18-0.3 lb/ Foliar application. For a preven-
1,000 sq.ft tive program, begin applications
503.0004 (3% G) before disease appears and repeat
or treatments as needed, usually at 10
0.2-0.3 lb/ to 14 day intervals. During extend-
1,000 sq.ft ed periods of cool, moist condi-
505.0004- (5% G) tions, applications at 7 day inter-
vals are advisable.--. To control
disease, repeat at 1 to 2 week
intervals throughout the spring and
summer months.
0.16-0.23 lb/ Foliar application. Apply using
1,000 sq^ft the lower rate for a preventive
103.9004 (3.9% G) program. Repeat applications at 2
week intervals throughout the
season. If disease is already
present, use the higher rate and
apply at 10 day intervals ^until
improvement is noted.
Formulated with zinc ion and manga-
nese ethylene bisdithiocarbamate 80
percent, a coordination product of
manganese 16 percent, zinc 2 per-
cent, ethylene bisdithiocarbamate
62 percent.
0.16-0.24 lb/ Foliar application. Use lower rate
1,000 sq.ft for a preventive treatment. Begin
04.0004 (4% G) applying from early spring to early
summer, repeating at 10 to 14 day
intervals as long as cool, wet
weather persists. For curative
treatment apply at the higher rate
at 10 day intervals until improve-
ment is noted.
Formulated with maneb.*
*Contains 0.1 percent zinc- as
metallic.
Issued: 4-07-79 11-080811-21
-------
Site and Pest
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIAZINE
Dosages and Tolerance, Use, Limitacions
Forraulation(s)
Ornamental Turf (continued)
Brown patch (Rhizoctonia) (continued)
&008.6004
&008.7004
&025.0006
&050.0006
&033.3306
0.13-0.22 lb/ Foliar application. Apply lower
1,000 sq.ft rate at 7 to 10 day intervals.
(8.6% G) During periods when conditions
favor disease (warm, humid
weather), use the higher rate and
apply at 7 day intervals. During
dry conditions, .water lawji at rate
of 10 gallons per 1,000 square feec
before treating.
0.23 lb/
1,000 sq.ft
(3.7% G)
Foliar application. Apply
treatment prior to or at first
indication of disease and
preferably on moist grass. Repeat
at 10 to 14 day intervals during
disease activity. In extreme
cases, use at 7 day intervals. Do
not water or mow for 24 hours after
applying. If rain occurs within 24
hours after application, re-apply.
0.13-0.25 lb/ Foliar application. Apply in 5
1,000 sq.ft gallons of water. Repeat at 1 to 2
(25% WP) week intervals throughout the
(50% WP) spring and summer months. For a
preventive program, begin
applications before the disease
appears and repeat treatments at
intervals of 10 to 14 days. During
prolonged periods of cool, moist
conditions, applications every 7
days may be advisable.
0.08 lb/ Foliar application. Apply in 5
1,000 sq.ft gallons of water. For a preventive
(33.33% WP) program, begin applications before
disease appears, and continue
throughout the spring and summer at
7 to 10 day intervals. Or, apply
when disease first appears and con-
tinue at 7 to 10 day intervals
through the season or as needed.
Formulated with diethyl
4,4'-o-phenylenebis(3-thioallo-
phanate).
Issued: 4-07-79
11-080811-23
-------
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIAZINE
Site and Pest Dosages and Tolerance, Use, Limitations
Formula tion(s)""~~~
Ornamental Turf (continued)
@FMAQSAQ Dollar spot (Sclerotinia)
Foliar application.
PFBAHRAM Refer to Brown patch (Rhizoctonia) for use and
limitation information.
(3FBAAFAK Fusarium blight (Fusarium roseum)
$3300801 0;16-0.23 lb/ Foliar application. Appty using
F 1,000 sq.ft the lower rate for' a preventive
&003.9004 ' (3.9% G) program. Repeat applications at 2
week intervals throughout the sea-
son. If disease is already present,
use the higher rate and apply at 10
day intervals until improvement is
noted.
Formulated with zinc ion and manga-
nese ethylene bisdithiocarbamate 80
percent, a coordination product of
manganese 16 percent, zinc 2 per-
cent, ethylene bisdithiocarbamate
62 percent.
F 0.16-0.24 lb/ Foliar application. For preventive
1,000 sq.ft treatment apply the lower rate.
&004.0004 (4% G) Begin applying from early spring to
early summer, repeating at 10 to 14
day intervals as long as cool, wet.
weather persists. For curative
treatment apply at the higher rate
at 10 day intervals until improve-
ment is noted.
Formulated with maneb.*
^Contains 0.1 percent of zinc as
metallic.
Issued: 4-07-79 11-080811-25
-------
EPA Index Co Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIAZINE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Ornamental Turf (continued)
Leaf .spot (Helminthosporium) (continued)
0.13-0.2 lb/ Foliar application. For a
1,000 sq.ft preventive program, use lower rate
&004.4504 (4.45% G) and apply before disease appears.
Repeat as needed, usually at 10 to
14 day intervals. During periods
of cool, moist conditions,
applications at--7 day intervals may
be advisable. To control disease
spread, use the higher rate as soon
as disease is noticed and repeat as
for preventive program.
0.13-0.27 lb/ Foliar application. Apply at 7 to
1,000 sq.ft 14 day intervals throughout spring
&005.0004 (52 G) and summer. Do not apply if rain
is expected within 24 hours. Do
not water lawn after application.
0.13-0.22 lb/ Foliar application. Apply lower
1,000 sq.ft rate at 7 to 10 day intervals.
&008.6004 (8.6% G) During periods when conditions
favor disease (warm, humid
weather), use the higher rate and
apply at 7 day intervals. During
dry conditions, water lawn at rate
of 10 gallons per 1,000 square feet
before treating.
0.23 lb/ Foliar application. Apply
1,000 sq.ft treatment prior to or at first
&008.7004 (8.7% G) indication of disease. Repeat at
10 to 14 day intervals during
disease activity. In extreme
cases, use at 7 day intervals. Do
not water or mow for 24 hours after
applying. If rain occurs within 24
hours after application, re-apply*»
Issued: 4-07-79 11-080811-27
-------
EPA Index Co Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILQ)-S-TRIAZINE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s) "~~~~
Ornamental Turf (continued)
FBATHAM Melting out (Helminthosporiura)
3300801 0.18-0.3 lb/ Foliar application. For a preven-
1,000 sq.ft tive program, begin applications
003.0004 (3% G) before disease appears and repeat
or treatments as needed, usually at 10
0.2-0.3 lb/ to 14 day intervals. During ex-
1,000 sq.ft tended periods of cool, moist con-
005.0004 (5% G) ditions, applications at 7_day in-
tervals are advisable. To control
disease, repeat at 1 to 2 week in-
tervals throughout the spring and
summer months.
0.16-0.23 lb/ Foliar application. Apply using
1,000 sq.ft the lower rate for a preventive
003.9004 (3.9% G) program. Repeat applications at 2
week intervals throughout the
season. If disease is already
'present, use the higher rate and
apply at 10 day intervals'until
improvement is noted.
Formulated with zinc ion and manga-
nese ethylene bisdithiocarbamate 80
percent, a coordination product of
manganese 16 percent, zinc 2 per-
cent, ethylene bisdithiocarbamate
62 percent.
0.13-0.2 lb/ Foliar application. For a preven-
1,000 sq.ft tive program, use lower rate and
304.4504 (4,45% G) apply before disease appears.
Repeat as needed, usually at 10 to
14 day intervals. During periods
of cool, moist conditions, appli-
cations at 7 day intervals may be
advisable. To control disease
spread, use the higher rate as soon
as disease is noticed and repeat as
for preventive program.
0.13-0.27 lb/ Foliar application. Apply at 7 to
1,000 sq.ft 14 day intervals throughout spring
)05.0004 (5% G) and summer. Do not apply if rain
is expected within 24 hours. Do
not water lawn after application.
Issued: 4-07-79 11-080811-29
-------
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIAZINE
Sice and Pest Dosages and Tolerance, Use, Limitations
Formulation (3)""
Ornamental Turf (continued)
Melting out (.Helminthosporium) (continued)
0.13-0.19 lb/ Foliar application. Apply in 6
1,000 sq.ft gallons of water. For a preventive
050.0006 (50% WP) program, use the lower rate and
apply before the disease appears.
Repeat at 10 to 14 day intervals.
During wet or damp weather,^ apply
at 7 day intervals. On new lawns,
apply as soon as seeds germinate
and repeat at 10 day intervals
until lawn is established. If
disease is already present, use
applications at 7 day intervals.
If disease is already present, use
the higher rate and make at least 3
successive applications at 7 day
intervals. After grass has recov-
ered, use the preventive program.
If necessary, water lawn before
applying. After treatment, do not
water lawn for 43-hours.
3AXCEF Red thread (Pink patch)
300801 0.16-0.23 lb/ Foliar application. Apply using
1,000 sq.ft the lower rate for a preventive
)3,9004 (3,9% G) program. Repeat applications at 2
week intervals throughout the
season. If disease is already
present, use the higher rate and
apply at 10 day intervals until
improvement is noted.
Formulated with zinc ion and manga-
nese ethylene bisdithiocarbamate 80
percent, a coordination product of
manganese 16 percent, zinc 2 per-
cent, ethylene bisdithiocarbamate
62 percent.
Issued: 4-07-79 11-080811-31
-------
Site and Pest
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIA2INE
Dosages and Tolerance, Use, Limitations
Formulation(s)
Ornamental Turf (continued)
Rust (Puccinia) (continued)
&004.0004
&004.4504
&005.0004
0.16-0.24 lb/ Foliar application. For preventive
1,000 sq.ft treatment apply the lower rate.
(4% G)
Begin applying from early spring to
early summer, repeating at 10 to 14
day intervals as long as cool, wet
weather persists. For curative
treatment apply at the*'higher rate
at 10 day intervals until
improvement is noted.
Formulated with maneb.*
*Contains 0.1 percent zinc as
metallic.
Foliar application. For a
preventive program, use lower rate
and apply before, disease appears.
Repeat as needed, usually at 10 to
14 day intervals. During periods
of cool, moist conditions,
applications at 7 day intervals may
be advisable. To control disease
spread, use the higher rate as soon
as disease is noticed and repeat as
for preventive program.
0.13-0.2 lb/ Foliar application. For a
1,000 sq.ft preventive program, apply the lower
0.13-0.2 lb/
1,000 sq.ft
(4.45% G)
(5% G)
rate in the spring before disease
is present. Repeat applications at
10 to 14 day intervals. During
periods of wet weather, apply at 7
day intervals. Continue
applications throughout spring and
summer- For curative treatment use
the higher rats. Do not mow or
water lawn for 24 hours after
treating.
Issued: 4-07-79
11-080811-33
-------
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROMILQ)-S-TRIAZINE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Ornamental Turf (continued)
Rust (Puccinia) (continued)
O.L3-0.25 Ifa/ Foliar application. Apply with
1,000 sq.ft garden hose sprayer or mix with 2.5
&050.0006 (50% WP) gallons of water and apply with a
compressed air sprayer. Use 0.13
pound for disease prevention and
0.19 pound for spot treatment of
diseased areas. -If using a field
sprayer, mix 0.13 to 0.25 pound in
5 gallons of water and apply. Begin
applying in spring before disease
appears and repeat at 10 to 14 day
intervals. During period of wet
weather, apply at 7 day intervals.
Continue treating throughout spring
and summer. If necessary, water
lawn before treating.
6FHAJFAK Snow mold (Fusarium)
$3300801 0.23 lb/ Foliar application. Apply in
F 1,000 sq.ft November and repeat during a mid-
&003.9004 (3.9% G winter thaw.
Formulated with zinc ion and manga-
nese ethylene bisthiocarbamate 80
percent, a coordination product of
manganese 16 percent, zinc 2 per-
cent, ethylene bisdithiocarbamate
62 percent.
F- 0.24 lb/1,000 Foliar application. Apply after
sq.ft first killing frost and in mid-
4004.0004 (4% G) winter when the ground,is free of
snow.
Formulated with maneb.*
*Contains 0.1 percent zinc as
metallic.
Issued: 4-07-79 11-080811-35
-------
Site and Pest
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-< 0-CHLOROANILO) -S-TRIAZINE
Dosages and Tolerance, Use, Limitations
Fo-nnulation(s) """""
Ornamental Turf (continued)
Snow mold (Typhula)
t025.0006
050.0006
050.0006
0.13 lb/
1,000 sq.ft
(25% WP)
or
0.06 lb/
1,000 sq.ft
(50% WP)
or
0.13 lb/
1,000 sq.ft
(50% WP)
Foliar application. Apply in 5
gallons of water. The first appli-
cation should be made after the
first killing frost in the fall. A
second application should be made
in mid-winter when the lawn is free
of snow, and a third application
after the final melting of snow in
late winter or early spring.
050.0006
050.0006
0.13-0.19 lb/ Foliar application. Apply in 6
1,000 sq.ft gallons of water. The first appli-
(50% WP) cation should be made after the
first killing frost in the fall. A
second application should be made
in mid-winter when the lawn is free
of snow, and a third application
after the final melting of snow in
late winter or early spring.
0.13-0.19 lb/ Foliar application. Apply with
1,000 sq.ft garden hose sprayer or mix with 2.5
(50% WP) gallons of water and apply with a
compressed air sprayer.
For disease prevention use the
lower rate and apply in the spring
before the disease appears. Repeat
at 10 to 14 day intervals. During
extended periods of wet weather,
applications at 7 day intervals may
be required. For spot treatment of
diseased areas, use the higher rate.
Continue treating throughout the
spring and summer months. If
necessary, water lawn before
treating.
Issued: 4-07-79
11-080811-37
-------
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-GHLOROANILO)-S-TRIAZINE
Site and Pest Dosages and Tolerance. Use, Limitations
Formulation (s) ~"~"
Ryegrass (continued)
Brown blight (Helminthosporiura) (continued)
0.13-0.2 lb/ Foliar application. For a
1,000 sq.ft preventive program, apply the lower
&005.0004 (5% G) rate in the spring before disease
is present. Repeat applications at
10 to 14 day intervals. During
periods of wet weather, apply at 7
day in t erva Is.--- Con t imie
applications throughout spring and
summer. For curative treatment use
the higher rate. Do not mow or
water lawn for 24 hours after
treating.
0.13-0.3 lb/ Foliar application. Apply at the
1,000 sq.ft lower rate where disease has not
&005.0004 (5% G) been a problem and a. preventive
program is desired. Apply 0.2
pound active per 1,000 square feet
where disease has been a problem
during previous years and a
preventive program is desired.
For a curative treatment, apply at
the higher rate in the early spring
and continue at 10 to 14 day
intervals as long as cool, wet
weather persists.
0.13-0.25 lb/ Foliar application. Apply with
1,000 sq.ft garden hose sprayer or mix with 2.5
&050.0006 (50% WP) gallons of water and apply with a
* compressed air sprayer. Use 0.13
pound for disease prevention and
0.19 pound for spot treatment of
diseased areas. If using a field
sprayer, mix 0.13 to 0.25 pound in
5 gallons of water and apply-
Begin applying in spring before -
disease appears and repeat at 10 to
14 day intervals. During period of
wet weather, apply at 7 day
intervals. Continue treating
throughout spring and summer. If
necessary, water lawn before
treating.
Issued: 4-07-79 11-080811-39
-------
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIAZINE
Listing of Registered Pesticide Products by Formulation
&092.0001 92% technical chemical
# 2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
003125-00199
&095.0001 95% technical chemical
j 2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
003125-00198
&050.0002 50% formulation intermediate
# 2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
00274SM)0094
&080.0002 80% formulation intermediate
# 2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
003125-00175
&005.0003 5% dust
# 2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
003125-00062
&003.0004 3% granular
# 2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
000827-00209 003125-00107
&003.9004 3.9% granular
2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811) plus zinc ion and
manganese ethylene bisdithiocarbaraate 80 percent, a coordination prod-
uct of manganese 16 percent, zinc 2 percent, ethylene bisdithiocarba-
# mate 62 percent (014504)
005238-00015
&004.0004 4% granular
2;4-dichloro-6-(o-chloroanilo)-s-triazine (080811) plus raaneb* (014505)
# *includes 0.1 percent zinc as metallic
000779-00068
&004.4504 4.45% granular
# 2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
003234-00037
&005.0004 5% granular
# 2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
000572-00214 000779-00097 001159-00174 003125-00125
003493-00007 004185-00211 005535-00096
&008.6004 8.6% granular
# 2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
000572-00250
Issued: 4-07-79 11-080811-41
-------
&008.7004
&025.0006
&033.3306
&050.0006
EPA Index to Pesticide Chemicals
2,4-DICHLORO-6-(0-CHLOROANILO)-S-TRIA2INE
Listing of Registered Pesticide Products by Formulation (continued)
8.7% granular
2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
000538-00073 -000538-00074
25% wettable powder
2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
010088-00037
33.33% wettable powder
2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811) plus diethyl
4i4,'-ro-phenylenebis(3-thioallophanate) (103401)
001001-00055
50% wettable powder
2,4-dichloro-6-(o-chloroanilo)-s-triazine (080811)
000004-00246 000239-02242 000904-00229 001990-00343
002169-00238 002217-00551 002217-00631 002749-00120
002749-00122 003125-00050 003125-00080 003125-00127
003125-00216 0^5535-00058 010155-00009
Issued: 4-07-79
11-080811-42
-------
EPA Index to Pesticide 'Chemicals
2,4-DICHLORO-6-< 0-CHLOROANILO)-S-TRTA2INE
State Label Registrations
CA Reg. No.
003234-04390 003234-04893
Issued: 4-07-79 11-080811-43
-------
Auxiliary Documentation (Update) December 9, 1983
2 , 4-Dichloro-6- (0-chloroanilino) -s-triazine
- 080811* -
This is auxiliary to the Fungicide Index Entry with an issue date of 04-07-79,
which was produced in February 1981. A current computer printout (PRD-1
issued: 12-02-83) shows that since February 1981, Registration * 000538-00073,
an 8.7% granular was updated in August 1981. A review of the updated label
showed that the "update" has not changed the rate of application, or the
use pattern of this product.
Three other registration numbers which did not appear in the original report,
but are on the current printout are as follows:
007001-00280 (50% WP)
007001-00281 (3% G)
009198-00064 (5% G)
The first 2 of these were in the process of being transferred between pesticide
companies and were unavailable when the index entry was being produced early
in 1981. The latter was registered in March 1982. The use patterns, rate of
application and target pests of these products are covered by the existing
index entry, therefore, updating in addition to this document, is deemed
unnecessary at this time.
Index entry validation: EPA Compenium of Registered Pesticides, Vol. II.
Fungicides and Nematicides, 6-01-74, Part I. pp. D-07-00.01-2
Signed:
Dean Hansen
Plant Pathologist
703/557-7494
*Anilazine
*Dyrene1"
-------
II. REQUIREMENT FOR SUBMISSION OF GENERIC DATA
A. This portion of the guidance document is a Notice
issued under the authority of ?I?RA Section 3(c){*2)(3)
and describes, in table format, the data required
for maintaining the registrability of each product.
Additionally, a bibliography (Appendix li-l") is
included that identifies that data considered as
part of the data base supporting this standard. SPA
has determined that additional generic data described
in this Notice must be submitted to EPA for evaluation
in order to maintain in effect the registration(s)
of your product(s) identified as an attachment to
the cover letter' accompanying this guidance document.
--As required by FIFRA Section 3 (c) (2) (B)'-> you are
required to take appropriate steps to comply with
this Notice.
b
SPA may suspend the registration of each of those products
unless, within the specified time, you have informed EPA
how you will satisfy the requirements of this Notice.
Any such suspension will remain in effect until you have
complied with the terms of this Notice.
B. What Generic Data -I/ Must 3e Submitted. You .may ascertain
which generic data you must submit by consulting Table A
at the end of this chapter. That table shows all the
generic data needed to evaluate the continued registrability
of all products, and the dates by which the data must be
submitted. The required data must be submitted and any
necessary studies must be conducted in accordance with
EPA-approved protocols, the Pesticide Registration
Guidelines 2/, or data collected under the approved
protocols of the Organization for Economic Cooperation
and Development (OECD) .. If you wish not to develop data
which are necessary to support the registration or
reregistration of certain uses appearing in your labeling,
you may deleta those uses at the time you submit your
revised labeling.
Also for certain kinds of testing (generally ecological
effects), SPA requires the test substance to be a "typical
formulation," and in those cases EPA needs, data of that
».
I/ Generic data pertain to the properties or effects of a
particular ingredient, and thus are relevant to an evaluation of
the risks of all products containing that ingredient (or all such
products having a certain use pattern), regardless of any such
product's unique composition or use. Product-specific data relate
only to the properties or effects of a product with a particular
composition (or*a group of products with closely similar composition.),
2/ The Pesticide Registration Guidelines were reproposed on
November 24, 1982 in 47 Federal Register 53192.
13
-------
type for each major formulation category (e.g., emulsifiabl.
concentrates, wettable powders, granulars, etc.) 'These
are classified as generic data and when needed are
specified in Table A. SPA may possess data on certain
"typical formulations" but not others. None: 'The "typical
formulation" data should not be confused with product-
specific data (Table B) which are required on each
formulation. Product-specific data are further explained
in Chapter IV of this document.
C. Options Available for Complying With Requirements
to Submit Data
Within 90 days of ^our receipt of this Notice you must
submit—to EPA a completed copy of the form entitled "FIFRA
Section 3(c)(2)(B) Summary Sheet" [EPA Form 8580-1, Appendix
II-2] for each of .your products. On that form you must
state which of the following methods you will use to comply
with the requirements of this Notice:
I. (a) Notify EPA that you will submit the data, and
(b) either submit the existing data you believe
will satisfy the requirement, or state that
you will generate the data by conducting
testing. If the test procedures you will
' use deviate from (or are not specified in)
the Registration Guidelines or protocols
contained in the Reports of Expert Groups
to the Chemicals Group, Organization for
"Economic Cooperation and Development (OECD)
Chemicals Testing Programme, you must enclose
the protocols you,,will use.
2. Notify EPA that you have entered into an agreement
with one or more other registrants to jointly
develop (or share in the cost of developing) the
data. If you elect this option, you must notify EPA
which registrant(s) are parties to the agreement.
3 File w-i^h EPA a completed "Certification of Attempt to
Enter Into an Agreement With Other Registrants for
Development of Data" (EPA Form 8580-6, Appendix II-3)_/
4. Request that EPA amend your registration by deleting the
uses for which the data are needed. (This option is no.
available to applicants for new proaucts.)
*1 FI^RA Sec-ion 3(c)(2)(B) authorizes joint development of
data by two* or more registrants, and P?ovjd« * °cfla^ **_
which parties can obtain an arbitrator's decision i. ney agr_
to jointly develop data but fail to agree on all .ne .erms o
the agreement. The statute does not compel any regis.ran. .o
acree to develop data jointly•
(Footnote continued at bottom of next page]
14
-------
5. Request, voluntary cancellation of the registration (s)
of your products for which the data are needed. (This
option is not available to applicants for new products.)
D. Procedures for Requesting Cnanges in Testing Methodology
and Extensions of Time
EPA recognizes that you may disagree with our conclusions
regarding the appropriate ways to develop the required
data or how quickly the data must be submitted. If the
test, procedures you plan to use deviate from (or are not
specified in) the registration guidelines or protocols
contained in the reports of the Expert Groups' to the
Chemical Groups, Organization for Economic Cooperation
and.,Development (OECD) Chemicals Testing Programme, you
must, submit the -protocol for Agency review prior to the
initiation of .the test.
If you think'that you will need more time to generate the
required data than is allowed by SPA's schedule, you may
submit a request for an extension of time. The extension
request must be submitted in writing to the Product
Manager. The extension request should state the reasons
why you conclude that an extension is appropriate. While
EPA considers your request, you must strive to meet the
deadline for submitting the required data.
(Footnote continued from previous page)
In EPA's opinion, joint data development by ail registrants
who are subject to the requirements to submit a pertinent item
of data or a cost-sharing agreement among all such registrants
is clearly in the public interest. Duplication of testing could
increase costs, tie up testing facilities, and subject an unneces-
sarily large number of animals to testing.
As noted earlier, SPA has discretion not to suspend ;he
reals-ration of a oroduct when a registrant rails to submit da^a
required under FI/HA Section 3(c)< 2)(B). EPA has concluded that
l^is appropriate to exercise its discretion not to suspena in
ways which will discourage duplicative testing. ^°**£^ lf
(1) a recristrant has informed us of his intent to develop and
submit llta required by this Notice; and (2) a -cond^regis- ^
trant informs EPA that it has made a bona fide or£e£.o ^e
to fores the second firm to engage in economically in.-^ic—n-
duplicative testing in order to maintain its regis.ration.
15
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
§158.120 Product Chemistry
Product Identity;
61-1 - Identity of Ingredients
61-2 — Statement of Composition
TGAI
TGAI
Yes
No
..I.
GS01140021,GS01140023
No
Yes
61-3 - Discussion of Formation of
Ingredients
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
62-2 - Certification of Limits
62-3 - Analytical Methods for
Enforcement of Limits
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical State
63-4 - Odor
63-5 - Melting Point
63-6 - Boiling Point ,
63-7 - Density, Bulk Density, or
Specific Gravity
TGAI
No
Yes
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
No
No
Partially
Yes
Yes
No
k Yes
Not Applicable
Yes
16
GS01140022
A/ A/
GS01140024,GS01140025
i/ i/
GS01140024,GS01140025
i/ i/
GS01140024,GS01140025
GSOJ 140024, GS01 140025
/
Yes
Yes
Yes"
3/
4/
Yes
No
Yes
i
Yes"
4/
4/
Yes
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/_
— 1 ~ 1
§158.120
63- 8 -
63- 9 -
63-10 -
63-11 -
Product Chemistry
(continued)
Solubility
Vapor Pressure
Dissociation constant
Octanol/water partition
TGAI OR PAI
PAI
PAI
PAI
Partially
No
No
No
1
6/ 6/ 5/
GS01140024,GS01140025 Yes
Yes
Yes
Yes
coefficient
63-12 - PH
63-13 - Stability
Other Requirements:
64- 1 - Subinittal of samples
TGAI
TGAI
Choice
No
Yes
Not Applicable
6/ 6/
GS01140024,GS01140025
Yes
i
Yes"
17
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
§158.120 Product Chemistry
(continued)
y Composition: TGAI = Technical grade of the active Ingredient; PAI » Pure active ingredient; Choice = Choice of
several test substances determined on a case-by-case basis. /
2J Data must be submitted no later than 6 monthsfrom the date of this Standard*
3/ Quantitative methods are required to determine impurities present at >0.1% by weight.
4/ This information must be submitted for the 92% technical formulation.
5J The lack of a specific quantity for water solubility constitutes a data gap as does the presentation of solubilities
in other solvents at 30°C (rather than the required 20°C). (Solubility should be expresses In terms of g/100 ml of
solvent at 20°C (68°F) or in terms of ppra (mg/kg)).
6/ Submitted by Mobay Chemical Company. May be compensable.
18
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirements
I/
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/.
§158.125 Residue Chemistry
171-4 - Nature of Residue (Metabolism)
- Plants
- Livestock
171-4 - Residue Analytical Method
- Plant residues
- Animal residues
171-4 - Storage Stability Data
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
- Crop Group #1 - Root and Tuber Vegetables
PAIRA
PAIRA and plant
metabolites
TGAI and metabolites
TGAI and metabolites
PAI
o Crop 1 - Potatoes
— Crop field trials
— Processed Food/Feed
TEP
EP
No
No
Yes
No
No
Partial
No
24 /
GSO1140004
Yes
Yes
Yes
i
Yes'
Yes
I/
4/
24/ 24/
GS01140005,GS01140006
Yes
6/
Yes
19
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirements
I/
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/.
§158.125 Residue Chemistry
(continued)
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
- Crop Group #2 - Bulb Vegetables (Allium spp.)
0 Crop 1 - Garlic
— Crop Field Trials
— Processed Food/Feed
TEP
EP
0 Crop 2 - Onions (green & dry bulb)
— Crop Field Trials TEP
— Processed Food/Feed EP
^
0 Crop 3 - Shallots
— Crop Field Trials TEP
— Processed Food/Feed EP
Crop Group #3 - Leafy Vegetables
0 Crop 1 - Celery
-- Crop Field Trials TEP
t
— Processed Food/Feed EP
Partially
Not Applicable
Partially
Not Applicable
Partially
Not Applicable
Partially
Not Applicable
24/
7/
GSO1140007
Yes
_24/ 24/ 8/
GS01140007,GS01140008 Yes
GSO1140009"
24/
9/
Yes
24/ 24/
GS01140010,GS01140011 Yes
20
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirement
I/
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?27
§158.125 Residue Chemistry
(continued)
171-4 - Magnitude of the Residue-
Residue Studies for Each
Food Use
- Crop Group /M - Fruiting Vegetables (except cucurbits)
0 Crop 1 - Tomatoes
Crop Field Trials
Processed Food/Feed
TEP
EP
Partially
No
Crop Group #5 - Cucurbit Vegetables
0 Crop 1 - Cucumbers
— Crop Field Trials
— Processed Food/Feed
Crop 2 - Melons
— Crop Field Trials
— Processed Food/Feed
TEP
EP
TEP
EP
Yes
Not Applicable
Partially
Not Applicable
GSO1140005"
24/
24 /
GS01140012
24/
GS01140013
Yes
ii/
12/
Yes
13/
No
14/
Yes
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirement
Composition
I/
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/.
§158.125 Residue Chemistry
(continued)
171-4 - Magnitude of the Residue-
Residue Studies (continued)
0 Crop 3 - Pumpkins
-- Crop Field Trials TEP
— Processed Food/Feed EP
0 Crop 4 - Squash (summer)
— Crop Field Trials TEP
— Processed Food/Feed EP
0 Crop 5 - Squash (winter)
— Crop Field Trials TEP
— Processed Food/Feed EP
- Crop Group #6 - Small Fruits and Berries
0 Crop 1 - Blackberries
— Crop Field Trials TEP
— Processed Food/Feed EP
Partially
Not Applicable
Yes
Not Applicable
Partial
Not Applicable
Partial
Not Applicable
24 /
GS01140014
GS01140015"
24 /
GS01140015"
24/
15/
Yes
16/
No
17/
Yes
_24/ _24/
GS01140016, GS01140017 Yes
22
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirement
Composition
I/
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Must Additional
Data Be Submitted
Bibliographic Under FIFRA Section
Citation 3(
§158.125 Residue Chemistry
(continued)
171-4 - Magnitude of the Residue
Residue Studies (continued)
- Crop Group #6 - Small Fruits and Berries
0 Crop 2 - Blueberries (huckleberries)
— Crop Field Trials
— Processed Food/Feed
Crop 3 - Cranberries
— Crop Field Trials
— Processed Food/Feed
TEP
EP
TEP
EP
Crop 4 - Dewberries and Loganberries
— Crop Field Trials TEP
— Processed Food/Feed EP
Crop 5 - Raspberries
— Crop Field Trials TEP
—Processed Food/Feed EP
Partial
Not Applicable
Partial
Not Applicable
Partial
Not Applicable
Partial
Not, Applicable
24 /
GS01140018"
GS01140019"
24/
GS01140017"
24 /
GS01140017"
24/
19/
Yes
20/
Yes
21/
No
21/
No
23
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2/.
§158.125 Residue Chemistry
(continued)
171-4 -
Magnitude of the Residue -
Residue Studies (continued)
Crop Group #6 - Small Fruits and Berries
0 Crop 6 - Strawberries
— Crop Field Trials
— Processed Food/Feed
TEP
EP
Crop Group #7 - Miscellaneous Commodities
0 Crop 1 - Tobacco
— Crop field trials TEP
— Processed Food/Feed
- Potable Water
- Fish
- Irrigated Crops
— Field trials
— Processed Food/Feed
- Food Handling t
- Meat/iailk/poultry/eggs
EP
EP
EP
EP
EP
EP
EP
TGAI or plant
metabolites
Partial
Not Applicable
No
Not Applicable
Not Applicable
Not Applicable
Not Applicable
Not Applicable
Not Applicable
.Not Applicable
No
24/
221
GS01140020
Yes
23/
Yes
Yes
24
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
§158.125 Residue Chemistry
(continued)
J_/ Composition: TGAI » Technical grade of the active ingredient; PAIRA » Pure activ^ ingredient, radiolabelled; TEP -
Typical end-use product; EP = End-use product.
2/ Data must be submitted no later than 6 months from the date of this Standard*
3J Tolerances for anilazine residues in or on plants are currently expressed in termg of the parent compound only.
Should plant metabolism studies show the parent compound is the only residue of concern, then the analytical
method submitted is adequate for analysis, but not for tolerance enforcement because other compounds (parathion,
methyl parathion, guthion, amitrole, chlorpropham, dlnoseb and diuron) may interfere. In this case, the
following data gaps exist:
0 Suitable methods are required for enforcement of all tolerances expressed in terms of the parent compound. If
the residues of concern in plants are determined to be compounds other than the parent moiety, then a suitable
method would be required which determines these residues.
0 A confirmatory test for anilazine residues in plants is required.
4_/ Required unless feeding studies indicate the feed uses are to be classified in category 3 of 40 CFR 180.6 (a),
i.e., no tolerances are required.
V The following additional data are required:
0 Field trials conducted in CA and either in ID, OK or WA which include multiple foliar applications (no less
than 12 at weekly intervals) with the 50% WP at 2.5 lb ai/A using ground and aerial equipment.
0 Field trials conducted in northeastern and northwestern growing regions which include multiple foliar
applications (no less than 12 weekly Intervals) with the 5%D at 2.0 lb ai/A using ground and aerial equipment.
The data should reflect residues from multiple applications (12 - 16) at the highest permissible application
rate applied up to the time of harvest.
_6_/ A processing study for dried potatoes, potato granules and chips will be required.
TJ The following additional data are required:
0 Field trials in CA reflecting multiple foliar applications (no less than 16 at weekly intervals) with the 5%D and
50% WP at the maximum recommended rate of 2 and 3 Ibs ai/A, respectively, using, ground and aerial application and
subsequent residue analysis of the dry bulbets (cloves) applied up to the time of harvest.
8/ The following additional data are required:
0 Field trials on green onions reflecting multiple foliar applications (green onions from sets require no less than
four treatments at weekly Intervals; green onions from seed require no less than 16 treatments at weekly intervals)
with the 5%D and 50% WP at the maximum recommended rates of 2 and 1.5 lb ai/A, respectively, using ground and aerial
equipment and subsequent residue analysis of the whole plant. Adequate geographic representation must be used (TX,
CA or AZ).
25
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
§158.125 Residue Chemistry
(continued)
0 Field trials on bulb onions reflecting multiple foliar applications (no less thafl 16 at weekly Intervals) with the
5% D and 50% WP at the maximum recommended rates of 2 and 3 Ibs ai/A, respectively, using ground and aerial
equipment and subsequent residue analysis of the dry bulbs up to the time of harvest. Adequate geographic represen-
tation must be used (OK or WA, CA and MI).
2/ The following additional data are required:
0 Field trials reflecting multiple foliar applications (no less than 16 at weekly intervals) with the 5% D at 2 lb ai/A
using ground and aerial equipment and subsequent residue analysis of the whole plant. Tests must be conducted in LA.
JLO/The following additional data are required:
0 Twelve weekly applications of the 5% D at 2 lb ai/A in CA or OR using aerial and ground equipment.
0 Tests conducted in western locations (CA or OR) using the 50% WP at 3 Ibs ai/A using both ground and aerial
applications (12 weekly treatments per season).
JUL/The following additional data are required:
0 Residue data from western locations, particularly CA using both the 50% WP and 5% D formulations at 2.5 Ibs ai/A and
1.5 Ibs ai/A, respectively, and using both ground and aerial equipment* At least eight weekly applications must be
made.
J^2_/Residue data for the processed products of tomatoes (catsup, juice, puree and wet and dry pomace) must be submitted to
determine the necessity of food/feed additive tolerances.
^13/Consideratlon should be given to a lower tolerance based upon the fact that the highest anilazine residue level
encountered was 1.23 ppm. A 5 ppm tolerance would be more appropriate.
following additional data are required:
Tests (8 applications) conducted in western locations, particularly CA, using both the 5% D and 50% WP at 3 Ibs al/A
and using both ground and aerial equipment.
_ following additional data are required:
0 Residue data from tests conducted in western, eastern and southern locations using both the 50% WP and 5% D
formulations at 3 Ibs ai/A. Twelve treatments must be applied using aerial and ground equipment.
16/Consideration should be given to a lower tolerance. A tolerance of 5 ppm would be more appropriate.
JjjVThe following additional data are required:
0 Tests conducted In southern and western locations using both the 5% D and 50% WP at 3 ibs al/A and using ground and
aerial equipment.
18/The following additional data are required: i
° Residue data for blackberries following 10 or more aerial and ground applications of the 5% D and 50% WP at 3 and 2
Ibs ai/A, respectively, made at weekly intervals in OR or WA.
26
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
§158.125 Residue Chemistry
(continued)
19 / The following additional data are required: ,
0 Residue data for blueberries reflecting at least 10 weekly aerial and ground applications of the 50% WP at 1.5 Ib
ai/A.
20/ The following additional data are required:
0 Residue data reflecting 16 weekly aerial and ground applications of the 50% WP at 3 Ibs ai/A conducted in WI.
2l/ When the requested data for blackberries are provided, they will be translated to dewberries, loganberries and
raspberries.
22/ The following additional data are required;
0 Residue data reflecting 8 weekly aerial and ground applications of the 5% D and 50% WP at 2 and 3 Ibs ai/A,
respectively.
23/ The following data are required to assess the exposure of man to residues of anilazine in or on tobacco:
0 Residue analysis of green tobacco after the last of at least 7 foliar treatments with the 50% WP at 1 Ib ai/A.
using ground and aerial equipment.
0 If residues in green tobacco are >0.1ppm, pyrolysis products must be characterized.
24/ Submitted by Mobay Chemical Corporation. May be compensable.
27
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
I/ Use 2J
Data Requirement Composition Pattern
§158.130 Environmental Fate
DEGRADATION STUDIES-LAB:
161-1 - Hydrolysis TGAI or PAIRA A,B,H
Photodegradation
161-2 - In water TGAI or PAIRA A,B
161-3 - On soil TGAI or PAIRA A,B
161-4 - In Air TGAI or PAIRA A,B
METABOLISM STUDIES-LAB:
162-1 - Aerobic Soil TGAI or PAIRA A,B,H
162-2 - Anaerobic Soil • TGAI or PAIRA A,B
162-3 - Anaerobic Aquatic TGAI or PAIRA A
162-4 - Aerobic Aquatic TGAI or PAIRA A
MOBILITY STUDIES:
163-1 - Leaching and TGAI or PAIRA A,B,H
Adsorption/Desorption
163-2 - Volatility (Lab) TEP A,B
163-3 - Volatility (Field) TEP A,B
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
Requirement? (Yes, Bibliographic Under FIFRA Section
No or Partially) Citation 3(c)(2)(B)?l/_
No
No
No
No
No
No
No
No
8/
Partially
No
No
4/
Yes
Yes
Yes
5/
No
6/
Yes
Yes
11
Yes
Yes
17/
00025729 Yes
Yes
Yes~
2«
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
11 Use y Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition Pattern No or Partially) Citation 3(c)(2)(B)?lZ_
§158.130 Environmental Fate
(continued)
DISSIPATION STUDIES-FIELD:
164-1 - Soil TEP A,B,H
164-2 -Aquatic (Sediment) TEP A
164-3 - Forestry TEP
164-4 - Combination and - -
Tank Mixes
164-5 - Soil, Long-term TEP A,B
ACCUMULATION STUDIES:
165-1 - Rotational Crops PAIRA A,B
(Confined)
165-2 - Rotational Crops TEP A,B
(Field)
165-3 - Irrigated Crops TEP A
165-4 - In Fish TGAI or PAIRA A,B
165-5 - In Aquatic Non-Target TEP A
Organisms
No
No
No
No
No
No
No
No
No
No
Yes
Yes
No
ll/
No
12/
No
Yes
13/
Yes
Yes
Yes
15/
Yes
16/
158.145 Reentry Studies
A,B
No
Yes
29
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
§158.130 Environmental Fate
(continued)
I/ Composition: TGAI «• Technical grade of the active ingredient; PAIRA - Pure active. Ingredient, radiolabelled;
TEP = Typical end-use product.
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
D=Aquatlc, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestie Outdoor; I=Indoor.
37 Data must be submitted no later than 48 months .
4/ Hydrolysis studies: One study was reviewed (05001459) that is scientifically invalid because it was not carried
out in darkness. All data are required.
5/ Photodegradation in Air: No data were submitted; however, no data are required because anilazine does not have
a greenhouse use.
6/ Aerobic soil metabolism studies: One study was reviewed (05001459) that is scientifically valid but does not
partially or totally fulfill data requirements because a 50% commercial formulation was used and not the
technical or purer grade of anilazine. All data are required.
2J Anaerobic aquatic metabolism studies: No data were submitted, but all data are required. The anaerobic aquatic
metabolism data may be substituted for the anaerobic soil metabolism data, but the reverse is not permissible.
8/ Leaching and adsorption/desorption studies: Two studies were reviewed; one study (00065859) is scientifically
invalid because anilazine could not be detected with enough precision by using a nonspecific fungal bioassay. The
other study (00025729) is scientifically valid and partially fulfills data requirements by providing soil TLC
mobility data on anilazine in six soils. To satisfy the terrestrial food crop uses, a study is needed to assess
the mobility of anilazine and its degradates after the pesticide has been aged in soil. Soil TLC, soil column,
or batch equilibrium (adsorption/desorption) techniques may be utilized. To satisfy the mobility data
requirements for the domestic outdoor use, batch equilibrium (adsorption/desorption) studies on a minimum of four
soils, such as sand (agricultural), sandy loam, silt loam, clay, or clay loam are required. For the aquatic use,
batch equilibrium (adsorption/desorption) studies on one aquatic sediment obtained from or representative of the
aquatic use area are required.
9/ Laboratory and field volatility studies: No data were submitted, but all data are required for the laboratory
~ volatility studies. All data may be required for the field volatility studies based on the results of the
laboratory studies.
10/ Forestry dissipation studies: No data were submitted; however, no data are required because anilazine does not
have a forestry use.
ll/ Dissipation studies for combination products and tank mixes uses: This data requirement is currently not being
implemented for this Standard.
30
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
§158.130 Environmental Fate
(continued)
12J Long-term field dissipation studies: No data were submitted* Data requirements fjpr long-term field dissipation
studies will be predicated upon the results of the terrestrial field dissipation study.
_13/ Field accumulation studies on rotational crops: No data were submitted* Data requirements for field accumulation
studies on rotational crops will be based on the results of confined accumulation^studies on rotational crops.
14/ Laboratory studies of pesticide accumulation in fish: No data were submitted; however, data may be required.
Fish accumulation data will not normally be required in situations where the registrant can offer evidence
acceptable to the Agency showing that the active ingredient and/or Its principal degradation product(s):
(i) Will not reach water, or
(ii) Will not persist in water (i.e., has a half-life of about 4 days or less), or
(ill) Has a relatively low potential for accumulation in fish as indicated by an octanol/water partition
coefficient less than about 1000.
15/ Required for use on cranberries only.
16/ Registrant is required to submit reentry data and recommendations for safe reentry intervals. An interim 24 hour
reentry interval is tentatively required.
17/ Submitted by Mobay Chemical Company. May be compensable.
31
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
I/ Use y Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition Patterns No or Partially) Citation 3(c)(2)(B)?3/
§158.135 Toxicology
ACUTE TESTING;
81-1
81-2
81-3
81-7
- Oral LD5Q - Rat
- Dermal LD50
- Inhalation LC5Q - Rat
- Acute Delayed
Neurotoxicity - Hen
TGAI A,B,H,I
TGAI A,B,H,I
TGAI A,B,H,I
TGAI A,B,H
Yes 00070075
Yes 00070075
No
No
No
No
Yes
4/
No
SUBCHRONIC TESTING:
82-1
82-2
82-3
82-4
- 90-Day Feeding -
Rodent, Non-rodent
- 21 -Day Dermal
- 90-Day Dermal
- 90-Day Inhalation -
TGAI A,H,I
TGAI A,B,H,I
TGAI A,B,H,I
TGAI A,B,H,I
5/
Partially 00070075
6/
Partially 00070075
No
No
Yes
Yes
Yes
7/
Yes
Rat
82-5 - 90-Day Neurotoxicity-
Hen/Mammal
TGAI
A,B,H,I
No
No
32
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirement
Does EPA Have Data
To Satisfy This
J_/ Use 2j Requirement? (Yes,
Composition Pattern No or Partially)?
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?J/.
§158.135 Toxicology
(continued)
CHRONIC TESTING;
83-1 - Chronic Toxicity -
2 species: Rodent
and Non-rodent
83-2 - Oncogenicity Study -
2 species: Rat and
Mouse preferred
83-3 - Teratogenicity -
2 species
83-4 -
Reproduction,
2-generation
MUTAGENICITY TESTING
84-2 - Gene Mutation
84-2 - Chromosomal Aberration
84-2 - Other Mechanisms of
Mutagenlcity
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
A,B,H,I
A,B,H,I
A,B,H,I
A,B,H,I
A,B,H,I
A,B,H,I
A,B,H,I
8/
Partially
Yes
No
No
Partially
Partially"
Partially"
JLL/
!!/
H/
!!/ !!/
00070076,00070077
GSO 11 40001
Yes
No
Yes
Yes
Yes
Yes
Yes
33
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
y Use 2/ Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition Pattern No or Partially) Citation 3(c)(2)(B)?j/.
§158.135 Toxicology
(continued)
SPECIAL TESTING
85-1 - General Metabolism PAI or PAIRA A,B,H,I No Yes
!!/
85-2 - Domestic Animal Safety Choice No No
34
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
§158.135 Toxicology
(continued)
\J Composition: PAI = Pure active ingredient; PAIRA » Pure active Ingredient, radiojabelled; Choice = Choice of several
test substances determined on a case-by-case basis.
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestie Outdoor; I=Indoor.
3/ Data must be submitted no later than 48 months «
_4/ Anilazine is not structurally related to a known neurotoxin. Therefore, an acute neurotoxicity study is not
required.
5/ The available subchronic feeding study in rats was classified as supplementary (see reviews for reasons).
Therefore two additional subchronic feeding studies (rat and dog) are needed.
_6/ The available 21-day dermal study In rabbits was classified as supplementary (see reviews for details). An
additional study is required because anilazine has been shown to cause dermal irritation and necropsy indicated
degenerative changes In brain, liver, heart and kidneys.
TJ A subchronic inhalation study may be required pending the outcome of the acute inhalation study.
8/ A 2-year feeding study in rats and a 1 year or longer feeding study in dogs are required.
_9/ Two teratology studies are required, preferably one in the rat and one in the rabbit.
10/ A 2-generation reproduction study is required in the rat.
ll/ For each test substance a battery of tests is required to assess potential to affect the qualitative or
quantitative Integrity of human genetic material. The objectives underlying the selection of a battery of tests
for mutagenicity assessment are:
a. To detect, with sensitive assay methods, the capacity of a test substance to alter genetic material In cells,
b. To determine the relevance of these changes to mammals and, when mutagenic potential is demonstrated,
c. To Incorporate these findings in the risk assessment for heritable effects, oncogenicity, and possible, other
health endpoints.
The battery must include tests appropriate to address the following three categories of genetic effects:
a. gene mutations
b. structural chromosomal aberrations
c. other mechanisms of mutagenicity (e.g., spindle Inhibition, direct DNA damage) as appropriate for the tested
chemical
Specific battery test selection and protocol design should be submitted to the Agency for comment and evaluation.
Registrants are encouraged to discuss results of preliminary testing with the Agency.
12/ Anilazine is not currently registered for any uses which would result in exposure to domestic animals through
direct application for pest control or by consumption of treated foods.
13/ Submitted by Mobay Chemical Corporation. May be compensable.
T4/ Only required for products used as additives to vinyl plastics.
35
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirement
I/ I/
Composition Pattern
Does EPA Have Data
To. Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
§158.140 Reentry Protection
132-1 - Foliar Dissipation
132-1 - Soil Dissipation
133-3 - Dermal Exposure
133-4 - Inhalation Exposure
TEP
TEP
TEP
TEP
A,B,H
A,B,H
Not Applicable
No
Not Applicable
Yes
Yes
\J Composition: TEP = Typical end-use product.
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
3/ Data must be submitted no later than .
36
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
J7 Use 2/
Data Requirement Composition Pattern
§158.145 Wildlife and
Does EPA Have Data
To Satisfy This
Requirement? (Yes, Bibliographic
No or Partially) Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/
Aquatic Organisms
AVIAN AND MAMMALIAN TESTING
71-1
71-2
71-3
71-4
71-5
- Avian Oral LD5Q
- Avian Dietary LC5Q
a) Upland Game Bird
b) Waterfowl
- Wild Mammal Toxicity
- Avian Reproduction
- Simulated and Actual
TGAI
TGAI
TGAI
TGAI
TGAI
TEP
A,B»
A,B,
A,B,
A,B,
A,B,
A,B,
5/
Partial GS01140002
5/ 9/
Partial 00030114
No
No
No
No
Yes
Yes
Yes
6/
No
I/
Reserved
I/
Reserved
Field Testing -
Mammals and Birds
AQUATIC ORGANISM TESTING
72-1 - Freshwater Fish LC5Q
a) Warmwater
TGAI
A.B.I
Yes
b) Coldwater
72-2 - Acute
Freshwter
TGAI
TGAI
A,B,I
A,B,I
Yes
Partial
V
00095691 4/
GS01 140003 5/
GS01 140028 5/
05009810 _5/
00095694
00095695 kj
GS01 140003
GS01 140003
/
No
No
Yes
Invertebrates
37
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirement
II Use 2J
Composition Pattern
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
§158.145 Wildlife and
Aquatic Organisms
(continued)
72-3 - Acute 1X50 Estuarine
and Marine Organisms
72-4 - Fish Early Life
Stage and Aquatic
Invertebrate Life-Cycle
a) Invertebrate
b) Fish
72-5 Fish - Life-Cycle
TGAI
72-6 - Aquatic Organism
Accumulation
72-7 - Simulated or Actual
Field Testing -
Aquatic Organisms
TGAI, PAI OR
Degradation
Product
TEP
6/
No
No
TGAI
TGAI
TGAI
A
A
A
No
No
No
No
No
Yes
Yes
Reserved
Reserved
7/
7/
7/
Reserved
38
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
§158.145 Wildlife and Aquatic Organisms
(continued)
\J Composition: TGAI » Technical grade of the active ingredient; PAI = pure active ingredient;
TEP = Typical end-use product;
2J The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food Crop; C=Aquatlc, Food Crop;
D=Aquatie, Non-Food; E=Greenhouse, Food Crop; F-Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
3/ Data must be submitted no later than 48 months .
4y Study on its own fulfills guideline requirements.
5/ Subacute dietary on an upland game bird and waterfowl required. Study submitted must be combined with other studies
to fulfill guideline requirements.
6/ Not applicable at this time.
T_l Reserved pending receipt and review of fish early-life stage and aquatic invertebrate life cycle tests.
8_/ Reserved pending receipt and review of environmental fate data.
9/ Submitted by FBI Gordon, Inc. May be compensable.
39
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirements
Composition
Does EPA Have Data
To Satisfy This
I/ Use 2/ Requirement? (Yes,
Pattern No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/.
§158.150 Plant Protection
121-1 - TARGET AREA
PHYTOTOXICITY
EP
No
No 4/
NONTARGET AREA PHYTOTOXICITY
TIER I
122-1 - Seed Germination/
Seedling Emergence
TGAI
No
No 4/
122-1
122-2
123-1
123-1
123-2
124-1
124-2
- Vegetative Vigor
- Aquatic Plant Growth
TIER II
- Seed Germination/
Seedling Emergence
- Vegetative Vigor
- Aquatic Plant Growth
TIER III
- Terrestrial Field
- Aquatic Field
TGAI
TGAI
TGAI
TGAI
TGAI
TEP
TEP
No
No
No
No
No
No
No
No 4/
No 4/
No 4/
No 4/
No 47
No 4/
No 4_/
11 Composition: TGAI = Technical grade of the active ingredient; TEP = Typical end-use product.
~~ EP = End-use product .f
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food Crop; C=Aquatic, Food Crop;
~~ D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, -Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
3/ Data must be submitted no later than > . .
4Y These requirements are generally waived unless It Is believed there is a phytotoxicity problem.
~~ 40
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirement
Composition
Use 2J
Pattern
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3/.
§158.155 Nontarget Insect
NONTARGET INSECT TESTING -
POLLINATORS:
141-1 - Honey bee acute
contact LD5Q
141-2 - Honey bee - toxiclty
of residues on
foliage
141-3 - Wild bees important in
alfalfa pollination -
toxicity of residues
on foliage
141-4 - Honey bee subacute
feeding study
141-5 - Field testing for
pollinators
TGAI
TEP
TEP
A.B.H
A,B,H
A,B,H
6/
(Reserved)
TEP
A,B,H
Yes
No
00036935
No
No
No
4/
No
5/
No
4/
No
41
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
Data Requirement
\J Use 2j
Composition Pattern
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)? I/.
§158.155 Nontarget Insect
(continued)
NONTARGET INSECT TESTING -
AQUATIC INSECTS;
142-1 - Acute toxicity to
aquatic insects
142-2 - Aquatic insect
life-cycle study
142-3 - Simulated or actual
field testing for
aquatic insects
143-1 - NONTARGET INSECT
TESTING - PREDATC
thru AND PARASITES
143-3
(Reserved)
(Reserved)
(Reserved)
(Reserved)
7/
42
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ANILAZINE
§158.155 Nontarget Insect
(continued)
\j Composition: TGAI » Technical grade of the active ingedrient; TEP « Typical end-use product.
2/ The use patterns are coded as follows: A = Terrestrial, Food Crop; B = Terrestrial, Non-Food; C = Aquatic, Food
Crop; D = Aquatic, Non-Food; E = Greenhouse, Food Crop; F » Greenhouse, Non-Food; G - Forestry; H = Domestic Outdoo;
I = Indoor.
37 Data must be submitted no later than .
kj As first tier (acute contact) test indicated low toxicity to honey bees, further testing is not required.
5/ Required only when product is intended for foliar application to seed alfalfa.
6/ Requirement reserved pending development of test methodology.
7/ Reserved pending decision as to whether data requirement should be established.
43
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING ANILAZINE
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?lZ.
§158.120 Product Chemistry
Product Identity
61-1 - Identity of Ingredients
61-2 - Statement of Composition
61-3 - Discussion of Formation
of Ingredients
Analysis and Certification
of Product Ingredients;
62-1 - Preliminary Analysis
62-2 - Certification of Limits
62-3 - Analytical Methods for
Enforcement of Limits
Physical and Chemical
Characteristics
63-2 - Color
63-3 - Physical State
63-4 - Odor
63-7 - Density, bulk density, or
specific gravity
MP
MP
MP
MP
MP
MP
MP
MP
MP
MP
Yes
No
No
No
Partially
Partially
Yes
Yes
No
Yes
GS01140026,GS01140027
GS01140021
GS01140022
i/ i/
GS01140024,GS01140025
GS01140021 ,GS01 140023
GS01 140026, GS01 140027
GSOl 140024, GSOl 140025
i/
No
Yes
Yes
Yes
Yes"
/
Yes"
/
Yes
No
Yes
c
Yes~
44
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING ANILAZINE
Data Requirement
I/
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
§158.120 Product Chemistry
(continued)
63-12 - PH
63-14 - Oxidizing or reducing
action
- Flammability
- Explodability
63-15
63-16
63-17 - Storage Stability
63-18 - Viscosity
63-19 - Miscibility
Other Requirements
64- 1 - Submittal of Samples
MP
MP
MP
MP
MP
MP
MP
Choice
No
No
No
No
No
Not Applicable
Not Applicable
Not Applicable
Yes
Yes
Yes
Yes
Yes
45
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING ANILAZINE
§158.120 Product Chemistry
(continued)
IJ Composition: MP =» Manufacturing-use product; Choice = Choice of several test substances determined on a case-by-
case basis. •
2J Data must be submitted no later than 6 months from the data of this Standard.
3J This information was only submitted on the 92 % technical formulation. ,
4/ Quantitative methods are required to determine impurities present a >0.1 % by weight.
5J This Information was only submitted on the 95 % technical formulation.
6J Submitted by Mobay Chemical Corporation. May be compensable.
46
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING ANILAZINE
Data Requirement
§158.135 Toxicology
ACUTE TESTING
81-1 - Oral LD50 - Rat
81-2 - Dermal LD50
81-3 - Inhalation LC5° - Rat
81-4 - Primary Eye
Composition
MP
MP
MP
MP
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Yes
Yes
No
No
Must Additional
Data Be Submitted
Bibliographic Under FIFRA Section
Citation 3(c)(2)(B)?2/
j
3/
00070075 No
3/
00070075 No
Yes
Yes
Irritation - Rabbit
81-5 - Primary Dermal
Irritation
81-6 - Dermal Sensitization
MP
MP
No
No
Yes
Yes
47
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING ANILAZINE
§158.135 Toxicology
(continued)
\J Composition: MP = Manufacturing-use product.
2/ Data must be submitted no later than 6 months
3J Submitted by Mobay Chemical Corporation. May be compensable.
48
-------
III. REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA
tfote: This chapter applies only to manufacturing-use oroducts,
not end-use products.
A necessary first step in determining which statements THUS-
appear on your product's label is the completion and submission
to EPA of product-specific data* listed on the form entitled
"Product- Specific Data Report" (SPA Form 3580-4, Appendix III-l)
to fill "gaps" identified by EPA concerning your product. Under
the authority of FIFRA Section 3(c)(2)(B), EPA has determined
that you must submit these data to EPA in order to register or
reregister your product(s)% All of these data must be submitted
not later than six months after you receive this guidance document.
"*' "Product-Specific Data Requirements for Manufa'cturing-Use
Products" appearing in, Table B permit you to determine which
product-specific data you must submit. This can be done by
examining the entries in the column of those tables entitled
"Must Data Be Submitted Under §3(c)(2)(B)."
data oertains to data that support the
* Product specc aa pe
formulation which is marketed; it usually includes product
chemistry data and acute toxicology aata.
49
-------
SUBMISSION OF REVISED LABELING AND PACKAGING INFQSMATTnN
not end^useduct9" aPPU8S Only tO "^"turing-u.. products,
_ The Agency requires applicants for registration or reregistra-
tion to ensure that each label (1) contains accurate, complete,
and sufficient instructions and precautions, reflecting the
results of data concerning the product and its ingredients, and
(2) incorporates labeling format and terminology which are suf^i-
ciently standardized to avoid user confusion.
As part of your application, you will be required to submit
draft labeling consistent with: applicable product-specific
data; the precautionary statements and use directions"- and the
regulations concerning classification [40 GFR §162. 11 ( c-) ] , pack-
aging [40 CFR §162.16], and labeling [40 CFR §162.10, Appendix
IV- 1 an IV- 2] , as indicated by the following paragraphs" of this
chapter of the guidance document.
You will be informed later when you must submit the revised
labeling set forth in this guidance package.
A. Label Contents
40 CFR §162.10 (Appendix IV- 1) requires that certain spe-
cific labeling statements must appear at certain locations'
on the label. This is referred to as format labeling.
Specific label items listed below are keyed to Tables D, S,
and ? (Appendix IV-2).
Item 1. PRODUCT NAME - The name, brand, or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading. See Appendix
IV- 1. [40 CFR §162.10(b)]
Item 2. COMPANY NAME AND ADDRESS - The name and address
of the registrant or distributor is required on the label.
The name and address should preferably be located at the
bottom of the front panel or at the end of the label text.
See Appendix IV- 1. [40 CFR §162.10(c}]
Item 3. NET CONTENTS - A net content statement is required
on all labels. The preferred location is the bottom of the
front panel immediately above the company name and address,
or at the end of the label text. The net contents must oe
stated in terms of weight, expressed as avoirdupois pounds
50
-------
and ounces, and stated in terms of the largest suitable unit,
i.e., 1 pound 10 ounces" rather than "26 ounces." In
addition to the required units specified, net contents inav be
expressed in metric units. See Appendix IV-1. [40 CFR ~
§162.10(d)]
Item 4. EPA REGISTRATION NUMBER - The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase "SPA Registration No.," or "SPA
Reg. No." The registration number must be set in type of a
size and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
registration number ,and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency. See Appendix IV-1.
[40 CFR §162.10(e')]
Item 5 . HPA ESTABLISHMENT NUMBER - The SPA establishment
number, preceded by the phrase "SPA Est." is the final estab-
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment registration number on
the immediate container cannot be"clearly read through such
wrapper or container. See Appendix IV-1. [40 CER §162.10(f)l
Item 6. INGREDIENT STATEMENT - An ingredient statement
is required on the front panel and must contain the name and
percentage by weight of each active ingredient and the total
percentage by weight of all inert ingredients. The preferred
location is immediately below the product name. The-ingredient
statement must run parallel with, and be clearly distinguished
from, other text on the panel. It must, not be placed in the
body of other text. See Appendix IV-1. [40 CFR 162.10(g)l
Item 6A. POUNDS PER GALLON STATEMENT - For liquid
agricultural formulations, the pounds per gallon of active *
ingredient must be indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS - All labels
are required to have precautionary statements grouped together
on the front panel, preferably within a block outline. The
table below shows the minimum type size requirements on
various size labels, as set forth in the Regulations.
51
-------
Size of Label Signal Word as Re- "Keep Out of Reach
on Front Panel quired Minimum Type of Cnildren"
in Square Inches Size All Caoitals as Reauired
3 and under 6 point: 6 point
above 5 to 10 10 point a point
above 10 to 15 12 point 3 point
above 15 to 30 14 point 10 point
over 30 13 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT - All labels are
required to have the statement "Keep Out of Reach of Children"
located on the front panel above the signal word except where
contact with children during distribution or use is unlikely.
See Appendix IV-1. [40 CFR §162.10(h)(1)(ii)]
Item 7B. SIGNAL WORD - The signal word (Caution, Warning,
or Danger) is required on the front panel immediately below
the child hazard warning statement. See Appendix IV-1.
[40 CFR §162.10 (h)(1)(i)]
Item 1C. SKULL & CROSSBONES AND WORD "POISON" - On products
assigned a toxicity Category I on the basis of oral, inhala-
tion^ or dermal toxicity, the word "Poison" shall appear on
the label in red on a background of distinctly contrasting
color and the skull and crossbones shall appear in Immediate
proximity to the word poison. See Appendix IV-1. [40 CFR
§162.10(h)(1)(i)]
I^em 7D. STATEMENT OF PRACTICAL TREATMENT - A statement
of practical treatment (first aid or other) shall appear on
the label of oesticide products in toxicity Categories I,
Jl and III! ^See Appendix IV-1. [40 CFR §162.10(h) (1) (111) ]
' »•»
I-am 7E REFERRAL STATEMENT - The statement "Sea Side
(or Back) Panel for Additional Precautionary Statements" is
required on the front panel for all products, unless all
recuired orecautionary statements appear on_the rron. panel.
lie Appendix IV-1. [40 CFR §162.10(h) (1) (ill) ]
I*-em 8. SIDE/BACK PANEL PRECAUTIONARY LABELING -The
that these statements be surrounded by a block °^-^e
of the three hazard ^«^9 s^^2 ««;LM ^^^162 10
appropriate hazard title. See x IV 1. I .u v. *
W (2)]
52
-------
Item SA.
hazard exists
statements ar
route(s) of e
HAZARD TO HUMANS AND DOMESTIC ANIMALS -
to humans or domestic animals, orecauti
(-
(n)(2)(i)J
Item 8B. ENVIRONMENTAL HAZARD - Where a hazard exists to
non-target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the^hazard and the appropriate precautions to avoid potential
accident, injury, or damage. See Appendix IV-l. [40 GFR
§162.10(h)(2)(ii)]
t
Item 8C. PHYSICAL OR CHEMICAL HAZARD
1 • Flammability statement. Precautionary statements
relating(to flammability of a product are required
to appear on the label if it meets the criteria in
Appendix IV-3. The requirement is based on the results
of the flashpoint determinations and flame extension
tests required-to be submitted for all products.
These statements are to be located in the side/back
panel precautionary statements section, preceded by
the heading "Physical/Chemical Hazards." Note that
no signal word is used in conjunction with hhe flam-
mability statements.
2. Criteria for declaration of non-flammability. The
following criteria will be used to determine if a
product is non-flammable:
a. A "non-flammable gas" is a gas (or mixture of
gases) that will not ignite when a lighted match
is placed against the open cylinder valve.
b. A "non-flammable liquid" is one having a flash-
ooint greater than 3503F (177°C) as determined
by the method specified in 40 CFR §163.61-3(c)(13)
(ii) of Subpart D.
c. A "non-flammable aerosol" is one which meets the
following criteria:
i The flame extension is zero inches, .using the
method specified in 40 CFR §163.61-S(c)(13)(ii);
ii. There is no flash back;, and
iii. The flashpoint of the non-volatile liquid
component is greater than 350 r (177 C), _
determined by the menhod specified in 40 CrR
§!63.61-8(c)(13)(i)•
53
-------
g;claga*ioP °* non-flammabilitv. Products which meet:
oie criteria tor non-flammability specified above mav
cear .he notation "non-flammable" or "nonflammable "
(gas, Liquid, etc.)" on the label.
It may appear as a substatement to the ingredients
statement, or on a back or side panel, but shall not
be highlighted or emphasized (as with an inordinately
large type size) in any way that may detract from
precaution.
4- 0-ther physical/chemical hazard statements. When
chemistry data ^submitted in accordance with 40 CFR
§163.61-10(c) demonstrate hazards of a physical or
__chemical nature other than flammability" appropriate
statements of hazard will be prescribed. Such"
statements; may address hazards of explosivity,
oxidizing or reducing capability, or mixing with
other substances to produce toxic fumes.
Item 9. MISUSE STATEMENT - The following statement is
required on your label: "It is a violation of Federal law ro
use this product in a manner inconsistent with its Labelina."
See Appendix IV-1. [40 CFR §162.10(1)(2)(ii)]
Item 10A. STORAGE AND DISPOSAL BLOCK - All labels are
required to bear storage and disposal statements. These
statements are developed for specific containers, sizes, and
chemical content. Make certain that the. statement you use
pertains specifically to your product. These instructions
must be grouped and appear under the heading "Storage and
Disposal" in the directions for use. This heading must be
set in the same type sizes as required for the child hazard
warning. Refer to Appendix IV-5 for the latest specific
storage and disposal product label statements.
Item 10B. DIRECTIONS FOR QSS - Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. When followed, directions must be adequate to
protect the public from fraud and from personal ^ injury and to
prevent unreasonable adverse effects on the environment. See
Appendix IV-1. [40 CFR §162.10]
B. Collateral Information
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, and other graphic printed matter which is referred to
on the label or which is to accompany the product are termed
collateral labelina. Such labeling may not bear claims or
representations that differ in substance from those accepted
in connection with registration of the product. It should be
made part of the response to this notice and submitted for review
54
-------
V. INSTRUCTIONS' FOR SUBMISSION
Ail applications prepared in response to this Notice should
be addressed as follows:
[Product Manager]
Phone No. (703)
Registration Division (TS-767)
Office of Pesticide Programs
Environmental Protection Agency
Washington, D.C. 20460
For each product for which continued registration is desired:
1. Within 90 days from receipt of this document/ you must
-submit the "FIFRA Section 3(c)(2)(3) Summary Sheet" EPA
Form 8580-1. .Refer to Appendix II-2 with appropriate
attachments. ,
2. Within 6 months from receipt of this document registrants
must submit:
a. Confidential Statement of Formula, SPA Form 8570-4.
b. Product Specific Data Report, EPA Form 8580-4 (Appendix
III-l).
c. Two copies of any required product-specific data.
3. Within the time set forth in Table A, all generic data
must be submitted by the affected registrant(s).
.Mote: If for any reason any required test is delayed ^aborted
so that meeting the agreed submission time will be delayed,
notify the Product Manager listed above-
You will be informed at a later date when you must ac70 , N
Aoolication for Amended Pesticide Registration (EPA rorm 8570-1)
SL££ revised labeling set forth in this guidance package.
55
-------
.Appendix II-l
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
00025729
00030114
00036935
00070075
00070076
00070077
Obrist, J.J.- Thornton, J.S. (1979) Soil Thin-Layer Mobility of
Baycor<.™j, Baytan(R), Drydene(*0 and Peropal(TM). (Un-
published study received Dec. 21, 1979 under 3125-EX-163;
prepared in cooperation with Agricultural Consultants, Inc.;
submitted by Mobay Chemical Corp., Kansas City, MO.: CDL:
099185-M.)
.DeWitt, J.B.; Stickel, W.H.; Springer, P.F. (1962) Wildlife
Studies, Patuxent Wildlife Research Center,'-1961-62. -
(Unpublished study received Jan. 2, 1980 under 2217-641;
prepared by U.S. Fish and Wildlife Service, Patuxent
Wildlife Service, Patuxent Wildlife Research Center,
submitted by PBI-Gordon Corp., Kansas City, KS; CDL:
241577-B.)
Atkins, E.L.; Greywood, E.A.; Macdonald, R.L. (1975) Toxicity
of Pesticides and Other Agricultural Chemicals to Honey Bees:
Laboratory Studies. By Univ. of California, Dept.. of
Entomology. ?: UC, Cooperative Extension. (Leaflet 2287;
published study.)
Treon, J.F.; Cleveland, F.P.; Hartman, L.; et al. (1953) The
Immediate and Cumulative Toxicity of 2,4-Dichloro-6-(0-
chloroanilino)-s-triazine (B0622). (Unpublished study
received Feb, 5, 1956 under PP0063; prepared by Univ. of
Cincinnati, Dept. of Preventive Medicine and Industrial
Health, Kettering Laboratory, submitted by Mobay Chemical
Corp., Kansas City, MO; CDL: 090061-A.)
Treon, J.F.; Cleveland, F.P.; Shaffer, M.S.; et al.(1955)
The Toxicity of 2,4-Dichloro-6-(0-chloroanilino)-s-
triazine When Administered Orally to Dogs in Serial Doses
Over Prolonged Periods of Time. (Unpublished study received
Feb. 5, 1956 under PP0063; prepared by Univ- of Cincinnati,
Dept. of Preventive Medicine and Industrial Health, Kettering
Laboratory, submitted by Mobay Chemical Corp., Kansas City,
MO; CDL: 090061-B.)
Treon, J.F.; Cleveland, F.P.; et al. (1955) The Physiological
Effects of Feeding Rats for Two Years on Diet Containing
2,4-Dichloro-6-(0-chloroanilino)-s-triazine (B-622).
(Unpublished study received Feb.5, 1956 under PP0063;
prepared by Univ. of Cincinnati, Dept. of Preventive
Medicine and Industrial Health, Kettering Laboratory,
submitted by Mobay Chemical Corp., Kansas City, MO;
CDL: 090091-0.)
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
00095691
00095694
00095695
05009810
GS01140001
GS01140002
GS01140003
GS01140004
GS01140005
GS01140006
GS01140007
McCann, J.A. (1969) Dyrene 98.3%: Bluegill: Test No. 137. (U.S.
Agricultural Research Service, Pesticides Regulation Div.,
Animal Biology Laboratory; unpublished study; CDL: 108543-A.)
McCann, J.A. (1969) Asgrow Turf Fungicide: Bluegill (Lepotnis
macrochirus); Test No. 212; Mobay 043135. (U.S. Agricul-
tural Research Service, Pesticides Regulation Div., Animal
Biology Laboratory; unpublished study; CDL:130363-A)
McCann, J.A. (1968) Dyrene: Rainbow Trout (Salmo gardineri);
Test No. 101 & 103:L Mobay 043136. (U.S. Agricultural
Research Service, Pesticides Regulation Div., Animal
Biology Laboratory; unpublished study; CDL:130364-A)
McCann, J.A.; Jasper, R.L. (1972) Vertebral damage to bluegills
exposed to acutely toxic levels of pesticides. Transactions
of the American Fisheries Society 101(2):317-322.
National Cancer Institute: Bioassay of Anilazine for. Possible
Carcinogen!city. CAS No. 101-05-3; NCI Carginogenesis
Technical Report Series No. 104(1972).
Tucker, R.K. and Crabtree. D.G. (1970) Handbook of Toxicity of
Pesticides to Wildlife. Bureau of Sport Fisheries and
Wildlife, Denver Wildlife Research Center.
Johnson, W.W.; Finley, M.T. (1980) Handbook of Acute Toxicity
of Chemicals to Fish and Aquatic Invertebrates. USDI Fish
and Wildlife Service, Resource Publication 137.
Meagher, W.R.; Anderson, C.A.; Gonter, C.E.; Smith, S.B.;
MacDougall, 0. (1959) Colorimetric method for the
determination of dyrene residues in plant material. Agric.
Food Chem. 7: 558-560. Submitted by Chemagro Corp. as
Report No. 4087 under PP0247; RGB Accession No. 113679.
Fassinger, W.P. (1956) B-622 Residues on Potatoes. Submitted by
Chemagro Corp. under PP0063; RGB Accession No. 113156.
Holstein, S.; Fassinger, W.P. (1957) Dyrene Residues in Potatoes.
Submitted by Chemagro Corp. as Report Nos. 1656, 1660, 1664,
1665, 1668 and 1736 under PP0131. RGB Accession No. 113346.
Holstein, S.; Adelman, D.; Anderson, C.; (I960) Dyrene Residues
in Green and Dry Onions. Submitted by Chemagro Corp. as Report
Nos. 1669, 2189, 2225, 2684 and 2837 under PP0215. RGB
Accession No. 113584.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GS01 140008
GS01140009
GS01140010
GS01 140011
GS01140012
GS01 130013
GS01140014
GS01140015
GS01140016
GS01140017
Anderson, C.A. (1959) Dyrene Residues in Green Onions. Submitted
by Chemagro Corp. as Report No. 3534 under PP0215. RGB
Accession No. 113584.
Anderson, C.A. (1960) Dyrene Residues in Shallots. Submitted by
Chemagro Corp. as Report No. 4750 under PP0247. RGB
Accession No. 113675.
Holstein, S.; Anderson, G.A. (1957) Dyrene Residues in Celery.
Submitted by Chemagro Corp. as Report Nos. 1657, 1672, 1739
and 1740 under PP0131. RC3 Accession No. 113346.
Adelman, D.P. (1958) Dyrene Residues in Celery. Submitted by
Chemagro Corp. as Report Nos. 2154, 2155 and 2156 under
PP0196. RGB Accession No. 113524.
Anderson, C.A. (1961) Dyrene Residues in Cucumbers. Submitted by
Chemagro- Corp. as Report Nos. 4888, 6722, 6724, 6733, 6737,
6744, 6750 and 6760 under PP0322. RGB Accession No. 113696.
Anderson, C.A. (1961) Dyrene Residues in Honeydew Melons,
Watermelons, Canteloupe and Muskmelon. Submitted by Chemagro
Corp. as Report Nos. 6720, 6721, 6726, 6727, 6728, 6730, 6731,
6735, 6745, 6746, 6747, 6748, 6754 and 6755 under PP0322.
RGB Accession No. 113969.
Quattrochi, L.P.; Anderson, C.A. (1961) Dyrene Residues in
Pumpkins. Submitted by Chemagro Corp. as Report No. 6743
under PP0322. RGB Accession No. 113969.
Anderson, C.A. ; Blake, G.H.; Quattrochi, L.P. (1961) Dyrene
Residues in Squash. Submitted by Chemagro Corp. as Report
Nos. 6725, 6732, 6749, 6751, 6752 and 6753 under PP0322.
RGB Accession No. 113969.
Anderson, C.A.; Johnson, F. (1961) Dyrene Residues in Black-
berries. Submitted by Chemagro Corp. as Report Nos. 6761 and
6762 under PP0322. RGB Accession No. 113969.
Anderson, C.A.; Johnson, F.; Haines, R.G. (1962) Dyrene
Residues in Raspberries. Submitted by Chemagro Corp. as
Report Nos. 4313, 4760, 6734, 6736 and 6759 under PP0322.
RGB Accession No. 113969.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under the Standard
GS01140018
GS0114Q019-,
GS01140020
GS01140021
GS01140022
GS01140023
GS01140024
GS01140025
GS01140026
GS01140027
GS01140028
Johnson, P.; Howitt, A.J.; Marucci, P.E.; Vaughn, E.K.; Reed,
J.K.; Varney, E.H.; Cough, K. (1962) Dyrene Residues in
Blueberries. Submitted by Chemagro Corp. as Report Nos.
8427, 8428, 8429, 8538, 8539, 8670 and 8686 under PP0363.
RGB Accession No. 114143.
Boone, J.M.; Cough, K. (1962) Dyrene Residues ,in Cranberries.
Submitted by Chemagro Corp. as Report Nos. 8368, 8369, 8370,
8371 and 8687 under PP0363. RGB Accession No. 114143.
Anderson, C.A. (1960) Dyrene Residues in Strawberries. Submitted
by Chemagro Corp. as Report Nos. 3977, 4315, 4318, 4319, 4402,
4637, 4690 and 4749 under PP0247. RGB Accession No. 113675.
Chemagro Corp.(1967) Confidential Statement of Formula for
EPA Registration No. 3125-199, dated Sept. 22, 1967.
Submitted by Chemagro Corp.
EPA. (1975) Anilazine EPA-1 (tentative) and EPA-2 (tentative-)
in Manual of Chemical Methods for Pesticides and Devices.
EPA, OTS.
Chemagro Corp. (1967) Confidential Statement of Formula for
EPA Registration No. 3125-198 dated Sept. 22, 1967.
Submitted by Chemagro Corp.
Chemagro Corp. (1960) Physicochemical properties submitted with
Publication Bulletin dated February 26, 1960 under PP0247.
RGB Accession No. 113675.
Chemagro Corp. (1959) Physicochemical properties submitted
with Publication Bulletin dated April 8, 1959 under PP0215.
RGB Accession No. 113584.
Aceto Chemical Co., Inc. (1975) Confidential Statement of
Formula for EPA Registration No. 2749-94, dated May 17,
1975. Submitted by Aceto Chemical Co., Inc.
Chemagro Corp. (1966) Confidential Statement of Formula
for Registration No. 3125-175, dated Jan. 26, 1966.
Submitted by Chemagro Corp.
McCann, J.A. (1968) Dyrene: Bluegill Sunfish (Lepomis
macrocfairus) Test No. 110 U.S.Agricultural Research
Service, Pesticides Regulation Div. Animal Biology
Laboratory.
-------
F1FHA SECTION 3{C)(2}(B> SUMMARY SHEET
CMS Aoarova/No. 20CO-C463 (Expires 12-31*33)
EPA REGISTRATION NO.
?HODUCT NAME
APPLICANTS NAME
OATS GUIDANCE DOCUMENT ISSUED
With respect to tha requirement to submit "generic" data imposed by the FiFHA action 3(C){2)(B) notica contained in tha referenced
Guidance Document, 1 am responding in the following manner:
Q1. I will submit data in a timely manner to satisfy the following requirements. If the test procedures I will usa deviata from {or are not
specified in) tha Registration Guidelines or the Protocols contained in tha Reports of Expert Groups to the Chemicals Group, QECO
Chemicals Tasting Programme, I ancioss tha protocols that I will usa:
Ql I hav« entared into an agreement with ona or mora other registrants under FIFHA section 3(C)(2)(8Kii) to satisfy ths following data
requirements. Tha tasts, and any required protocols, will he submitted to EPA by:
NAME OF OTHER REGISTRANT
I enclose a completed "Certification of Attsmpt to Entar Into an Agreement with Other Registrants for Development of Data" with
respect to tha following data requirements:
U 4, I request that you amend my registration by deleting tha following uses (this option is not avaiiabia to applicants for new products):
QI I request voluntary cancailation of the registration of this product. (This option is not available to applicants for new products.)
REGISTRANTS AUTHORIZED REPRESENTATIVE
i SIGNATURE
OATS
Form 3580-1 (10-S2)
-------
(To (justify, csrrify ALL four items}
1. I am duly authorized to represent the following firm(s> who are subject to the require-
ments of a Notice under FIFRA Section 3(c)(2)(B) contained in a Guidancs Document
to submit data concerning the active ingredient:
GUIDANCE COCUM6NT OATS
ACTIVE INGflSOISNT
NAME OF FIRM
SPA COMPANY NUMBER
(This firm or group of firms is referred to below as "my'firm".)
.2. My-firm is wiliing.to develop and submit the data as required by that Notice, if necessary. However, my firm would prefer to enter
into an agreement with one or more other registrants to develop jointly, or to share in the cost of developing, the following required
items or oata:
3. My firm has offered in writing to inter into such an agreement. Copies of tha offers are attached. That offer was irrevocable and included an offer to be
sound ay an arbitration decision under FJFRA Section 3(cH2)(BMiii) if final agreement on aii terms could not be reached otherwise. This offer was made
to the following firm
-------
Acpendix ZH-1
PBDEDCT SPECIFIC CKTA a
23A Pegistraticn Mo, Guidanca Cccunat Sap
Cats .
Segistcaticn
Guideline Mo.
PSDUJCT
CHscarsy
61-1
Si-2
5.2—2
SF3
53-2
63-3
63-4
53-5
53—0
63-7
53-4
53-9
53-10
53-U
>Taine af Taat
inorsdianr?
conscsitioi
fccmacicn of
inoradients
Preliainary
analvsis
Cart,i£icatticn oc
limits
Analytical xenxcs
for tinzcccajft-inc.
Limits
Color
Tast not
required
fcsr 37
product
Listed
above
(check
below)
i I am ccnoiying wiaa j
daca recuirsnents bvt
Citing MSID»
5uo3iit-
ting
Data
(At-
(For EPA Use Only)
Accession Mumcers
Phvsical scata I
Gccar i
Melting ooint 1
Soiling coin-c I
Density, culic-
densit7» or
scecific cravif/
i
Soluoilj.tr/ i
Vaccr oressurs i
Oiss'rr!'? "liicn
ccnstant
Qctanol/warar
partition
coefficient
63-12 ! OH
63-13 1 Stability
53-14
Oxidizing/reciucingi
raaction
53-15 riaronao-Llicv
63-16 aeDlodaoilicv > i
63-17 Sccrace stiacil-r/ ;
53-13 Viscesir/ :
53-19 1 Miscibiiitv i
63-20
63-21
§153.135
31-1
31-2
31-3
31-4
31-5
Cctrcsion
(^U£ij
-------
t ftrttattt:*.. umy not ccMtstutsr
;i «.ii|>f>ortlii4r ilto »|>j>l
Mitt tallowing 4Julu:
<1> 1'lic data ||k<: applicant |iu«
inltted to SJpA under paragraph (b> of
|hia secllim;
(U) Other tlu|a pcr|ulnlng (a the
safety ol the product'* active ingred|-
cnla. rather than lo iliu safety of the
cud iifiu product; und.
(3) Existing tolerance*, food additive
regulation*, exemptions, ami other
clearances hunted Under tho |i'edera)
Food. Drug, and Cosmetic Act.
(o) II the applicant known that any
item ol data he imbmlttcd under
section waa generated by (or tit tho
pcnao of) another person who orlglna}-
iy submitted tho data to BUPA (or IU
predecessor. U£iOA) on or alter Janu-
ary I. Ifl'/O. to support an application
for registration, experimental uso
permit, or amendment Adding A new
use to un existing ituhtiallon, or for
icrcgbtrallon (uuleu4 the applicant
and the original data tiubmlllor }iayo
reached written agreement on tho
amount und the |cims ol payment of
any compensation that may bo pay-
able tinder HfllA scct|on
Str.HIHDHlO with regard to approval
ol the application), tho applicant ahull
utibmlt io liil'A a statement that ho
has furnished lo each witch Identified
original data submitter:
(I) A notification ol tho applicant**
Intent to apply lor registration. includ-
ing the proposed product name;
I'i) An oder to pay tho person com-
petiaatlon. with regard to the approval
ol the application, to the extent le
Quhed by 1 ll'UA tiecMon« 3(e>(lH|))
.and 3(c)(a>(I»;
(3) Au Ideutllleatlou ol the |lem(a)
ol data to which the oiler applies;
H> An ofler to commenco negotla-
tloutt to ascertain the amount and
terma ol compensation to be paid; and
(6) The applicant'** name, addieaa,
and telephone muuhcr.
(I) II the applicant'!! product coi»
talnn any active tuuretllent other than
llmae that are present aolely becanao
ol the Incoiparatlon l>'to the pro iha «iu»M
eutluit relies on (and «ity reuniting rug-
(utratlou uhonld ho regarded aa || |t
were buacd on the Ailmlnlutialor'u eon-
fdderalloii ol) the lollowlng data;
<|) All data submitted or Hpeclllcally
cited |»y tho applicant In aiipport o|
t)ie reglulratlon; and
ftach other Hem of data In, tho
'tf I Hen which:
(U Conceinu tho properties or
of any mich act|yo [ngredicikl; and .
(10 In ono of tho type* of data, that
)ilf A would require to Lo submitted for
flclentlllo review by fcPA II tho appll-
punt uought tho Inltlu) registration
linder FfHlA Section a<6> of »
product with coinpoultloa and Intend
ti\ uaca Identical to thouo |>ropoued lor
tho applicant'* product, under the
data rcqutrententu hi (tiled on lite
date kH'A approveu the applicant*!
application.
iticct. ». •. And
. M.y II.
. M
| fil.ltt I.*bc|lu| *c<)idrciutiiU.
(a) {)cncral~(l} Contenti cj (he
label fivery petttlelde prodnctn «hul)
bear a label containing tho Infoima
tion apecllled by tho Act and tho rcgu-
jalioiuj In thl« Part. Tho content* of a
label mtidt ahow clearly and pioiuj-
|tently the loliowlng:
(I) The name, brand, or trademark
under which tho product Iq aold an pre
Dcrlbed In paragraph (b) of thb «ec-
(l'>n;
(10 Tho name and addreoa of the
producer, registrant, or peruon lor
Whom, produced aa prescribed lit para-
graph (c) of thla aeclton;
(|1O The net contents a« pieaerlbtd
lit paragraph (d) ol thlu aeetlon;
(!y) The product registration
pumber au prescribed In paragraph (e)
ol thla uectlon;
(v) The piodticlng eulablluhment
Itumber an prescribed In paragraph (I)
of thU ueollon;
(yO An Inuiedlent atutcment an pre
bcribet) ji| puragiaph (g) of tbla iiec-
|lon;
ol
Ivlll)
14*'
and
In
(U) The nuo clauulHeallon(s> aa pre-
scribed |ii paragraph t J> of this aectlon.j
omlMcucfl and ffulMllly. (O Al|
. talenient«. «rapli|<: rcpreseiita
a. dculgna or other |ulPf»'"|l«»n re
en additional
text |i| another language in necessary.
all labeling reqtiireinenl4 will be ap-
plied equally to both tho Iriiiglltih and
Other |aitgu*go veiulons of the label-
ing.
(4) Macctncnt cj Lubv\-(\\ Ucnaial.
T|ie label ehall appear on or be uecnie
Iy attached to the Immediate contain-
er ol the pesticide product, l^or pur-
pouea ol this fiect|ou. an«| the |nla
brand .ig provUloim ol the Act. "se-
curely attached." tdiall mean that a
label can reasonably be expected to
lemutii itlflxed during the foreseeable
conditions and period of use. II the lii»
iuedlate container la enclosed within n
wrapper or outside container through
which the label cannot be clcaily |cud.
the lube) must also be uccurely at-
tached lo such outside wrapper or con-
tainer.' |l It I* a part of (lie package aa
citstomailly illstf (bute^ or sold.
(II) 'Juit* CUM (iiuf other bulk cou-
faiin:ra-(A) Twn jpor/afjoii. While A
pesticide prot|uc|. la ||i (rai|sit, ||ie ap
|y iikotitt i>iowlalons» cun^uiikluu like it»-
liclliiU. tuaiktag ikiul plucartltikft ol |ku£-
ftiilaua iitaturlala und the vehicles car-
rying them, define the baale f-'eilerul
requhementa. In addition, when any
icgtateicd pesticide product Ut liana
ported hi a lank car. tank truck or
other ntoblic or portable bulk contain-
er. * copy ol tho accepted label must
bo attached to t|te shipping pupeis,
tt|M| left with the conulgnpe ut tpe |lnte
pf i|e|lvci y.
of the
Act. a pesticide Of u tfcviec declared
subject lo the Act pursuant to | 1^2 16,
|s inisbranded II Its labeling la lalse or
inlsleadlug In any particular Including
both pctillcldal and non pcsllcidul
claims. Kxamplcu of statements or rep
rcsentatlonu In the )abe||ng wlilch co|i-
utitnto inlubi andhuj Include:
(|> A false or misleading btatemenl
concerning the composition of the
product;
((I) A false 01 misleading statement
concerning the ellecilvene^s o| the
product as a pesticide or device;
(110 A fahic or misleading blatcment
about the value ol t|»e product lor
purposes other than as a pesticide or
device;
(lv> A lalae or misleading cnmpaifoon
with other pesticides or devices;
(V) Any statement dlicctly or Indi-
rectly Implying thai the pesticide or
device b recommended or endorsed by
any agency ol tbe Federal Oovcrn
(v|) The name o| a pestlcMe which
contains two 01 more pilnclpal active
Ingredients i| the name augifests one
or inore but not all such principal
active Ingicdlcnid even t|toiujh the
pames of the other Ingiedlenla are
6|ated clsewhen: In the labelinu;
-------
$ 142-10
t vll) A initi Alutuiuuiil iiucd In mjcli a
way u* (it iflvu u fuhiu or mlaleadlng Im-
prcu.j|on to thu pnrchuacr;
(vlll) I-ubcl dlficlulmeru which ncgutu
or dcliuct from lubcllng alutumcnta ru-
ijuhcd under ilia Act um| Ilium; regula-
tions;
"pollution approved"
ffuul pijnidd lulnllny. (!) Hixcept
ua provided in paragraph (uUaiilO t>|
ihla bccilon. final printed labeling
mntd. be aubmltlcd uiul accepted in lor
io rcufotrutlan. However, finut pifnted
labeling need not be uubmlltcd until
thu(t label tcxU have been provision
ully accepted by tho Agency.
(U) Clearly legible reproduction* or
photo icductlonti will bo accepted lor
tmuMiul luhclu imcii ua thoau allk-
liciccncd directly onto gluua or metu|
cmilulncitt or large bug or drum luhclu.
finch rcproductlona miitit be of micro
(Ihu reproduction tpiullly.
(hi tin inc. bin \id. or liudtiinaik. Ill
'l°hc iiunie. Wund. or tiudcmaik under
vuhluh the peutlcldu |>roducl |a uold
tthul! uiu>eur on thu front jtunc) of tho
-IQ —
of
Ci) HO numu. biund. or
muy uppcur on the luhcl which:
h> luliiti or mlidcudlng, or
(Ih Uuu not been approved by the
Administrator through keglutratlon O|r
unpideioentut regbtrbtlon au an udd|
tlonui name puitaiunt io | Id'i fi(h)(4>.
(<;> Hume and uddietiu ol producer.
rcuLliant. or peiuon for vnhoiu pro
dnced. An unnuaU/led numc and ad
dn;u^ given on the label ahull be con
bldercd aa the name and addretia of thu
pioduc-er. It the ictfLtranl'ti nwine ap
peuru on the label and the reultitrant la
|u>l the pioducer. or If the name of the
person for whom the 'pesticide w/ua
uppctira on l|ie label. It
£011-
bu qualified by upproprlulu wording
aneli aa "fucked /or • t *." ")>lutrlhiit
ed by » * V or "flold by • • f to ahow
that thu numa la pot that of thu
ducer.
(d> Net wetoht or tntuiura
ftiiifj. (1) Thu net weight or
of content ahull bu exclnulvu of wrup-
peru or other mutcrlula and) ahull be
the average content tmleuu explicitly
atutcd aa u minimum Quantity.
(4) If thu peatlcldu la A llauld. thu
ne(, content, atatcmcnt ahull bu In
ierma of llmijd mcuauro At OH* V fiUTOl
knd ahull be expreaded |n conventional
American nnltu of flnlt) ouficea, pjniai
qnui la. and gallon*.
(3) II |hu peutlcldu la aol|<| or aemluo-
|ld. ylacoua Or pieaam Ized. Of hi & mix
luru of lltjnld and aolld. the net con-
tent aiatement ahull bu |i} ternu of
weight oxprcuacd 04 uyolrdupoia
pouiuia and ounce*.
H) In all cuaea. nut content ahull bo
atalud In terma of thu largeat auilablc
tmita. I.e., 'T pound 10 ounceu" rather
thai* "Jl4 ouncea."
(6) la addition to thu required unlU '
apeclfled. nut content may bu tx-
pieaacd In metric tmlU.
$6} Variation abovo minimum con-
tent or around an average la ,
bio only to thu extent that It
acnta deviation unuvoldublu In good
manufacturing practice. Variation
below a utatcd minimum la not permit
ted,. In no cuau ahull thu average cuii-
tent of thu package* |n A ahlpmcnt full
below the atated average content.
(u) fVoduef rii/lj/iuifoii number.
Thu registration number uaalgned la
the pc*ilc|du product at thu lima of
legislation uhull appear on thu label.
preceded by thu phruau "Ei»A lleidj
(ration MO.." or the phruau "bJI'A lUtt
No." The icgMrutlon number ahull bu
act In type of a uke and utyle ulmllur to
other print on that part of thu lubcl
on which It appear* and ahull run par-
allel lo It. Thu regliitrutlon number
and thu remilred Identifying phratio
ahull not uppeur In aucli A munner M
|o ttiigucat or Imply recommendailoii
or endoraement ol thu product by the
Agency.
(f) fitnlticlim Giltilllihiucnlt
Italian number. Tim pi<»duclng
jluhment |egla|rutlon number pieced-
fed by the phruuu jiU'A t^t/1. of ||ic
eatabllahment lit which thu prod-
waa produced |ouy appear |i| any
tollable location on |h« label or Jmmo
dlulii container. |t louat appear on thu
wrapper or onlaldo container o| the
puckugu If thu BPA catabMalnnu»4 reg
Utratlon number pn the juuotdiutu
contaluer wwuwi be clearly read,
through tiucli wrapper or container.
each peutlcldu product
imiid bear A aUttment whlcji conlalna
jbu name aiid pcrcentagu by wclglit of
«ach ucilvd Inifredlciit. tho tola) pe|-
ccniugu by wclfchl °' ttM *n^rt I'^rviil-
|:nU; fend If |be pealtcldu contain* ar
' in Any foi|rt. A ulalement of tho
»ge* of total and water aolnblu
calculated aa A|en>e|itu| ar
c. Thu ftctlvu jngredlenta mu&f bu
j by thu term "act|vu Ingrcdl-
n" aiid thu Inert Ingredient* fry tho.
term "Inert |ngret|ien!a." or the *(iigu^
foinu of (.huflu tcrma when appro-'
'e. Dotli term4 ahull bu In the
typo aba. bp aligned |o (he aume
m«ri(li) und be emially prominent. Thu
Ktnleiuent "Inert Ingredients, none" |a
not rcmilred for peatlcldea w)tlch con
ihln lOA percent active lngrcd|cnia.
thu Ingredient atittement |a A
tu aitulyula of thu peatlclde. |he
ui "ttimlyula" ahull not bu naed aa A
iicnillng for thu Ingredient alutemcnt
t)) )kOiUo appear on *uc|i onlaldu container
ur wi upper. If thu uUe or form of thu
common mime may bu iiaud alone on|y
If jt la well known. If no common name
tad been ctduhlbhcd. thu chemical
name alone ahal) be uacil. In no ciue
w||| the iiue of u tiwdemurk or propri-
etary nume be permitted nnlcua titich
iiaine liua becit atictn(mnii The
peicentagcu of Ingrcdlenta ahull be
Atated la tuima of u/plght to weight.
'J'|io mini of percentage^ of the u<
Mild fhu Inert. Ingiedlenta uliull bu
Perccntagca b|iul) not be expreaacd by
A ruiige of Vitluca an^lt it* "54 36%." If
|he pae* of fho pi^tlddu product are
expreaued a* weight of active Inured!
£||l per unit urea. A atuteinent o| tho
Welglit of A.ct|vc ingredient per unit
yohime of |he public
tihall uluo appear In
«!utci|tcnt.
The percentagca given ahull bo ua pie-
clue aa po&dhlu reflecting good munn-
fuctnrlng practice. If there may be nn
Avoidable variation between inunnfuc
filling butchu*. t!>e value slated for
' active Ingredient ahu)| bu thu
j|_ percuiituge which muy pe prea-
po
bayard to man o, the cnvlro.unent,
-------
9 142-10
fill* 4O
. . on tho froni panel of
ihe labeling und ihoac wh|e|i may
appear elaeu/hcrc. fipeclfle require
nieiitu concerning content, placement.
iypo ulze. and prominence are given
below.
(I) llwiulicil Joint panel ttuteincnlt.
With ihe exception of t|ic child
of
warning idutemeni. ihe le*i re-
quired on ihe Irani pune| of ihe label
)u determined by the To x Icily Calego-
ry »f Hie pctdlclde. The category la *u-
ttfgned on the Imala of ilia hlgheui
hftzurd uhown by any of ilia Indlcalqrtt
|u the tah|o below:
' N
ollucll
tiklik
k&
f isun 60 MMU MX) f»||/ku f'ft
flam a Mwu t MIQ/IU*.... f io
fltMit 200 Muu ttXHI f 10m t.OOU Huu 80.000..
Hit C*JJH*«
I'll
Mt*n 20.MMI.
IUv«M« IllUilkMi •( lit
tlkm *|
I
Jluiiuiii
yoiv 1. AU pcullchlu |troti
ucia meciluu thd cilluilu o|f T^^lclly
Category 1 tihb\| bcur on i)io lion^
l>uiu:l itiu uluual word "liungiir." in ft^
tlltlfiu l( ilte protliici u/uu aauluucti |o
Toxicliy CuUfcoiy 1 on ihc buiih of IU
orul. laltulutlon or durum) ioxlcliy (ua
dlullnci (tout aktn and cyu loca) c(-
fuclu) the word "i'oluon"
In led on it background of dbti
color und fhc ukit|l
ihuU u|tpuar In liiunti
to ibo word "i>oluuii."
I/.
prodiiutii ikicettnu the crUcrlu of
Cutcuory II ahull bcttr on ilio
fiout auuel tl»e ultfnu| word "Wurn
flf. All
ii |>iodtu:t^i incctlag the oillcrU of
1'okliUty Cutotfory 111 uhull bear oi>
the fioni |iune| the ftluaul won) (''utcgory IV Ahull bcur on ibA
fioal puiiel the uluaul word "fruition."
j und) the ulatemenl "keep out of
reae|i of oblldren." Only In ciujc»
where ilte likelihood of contaei with
children «larlag distribution, inurkot
lag. utorugu or hue la demonutralcd by
Ihe appllcuni to be extremely le
or If the autin e of the peutlcldu lu
ibul li |u approve^ for aaa on In
or itmall children, may the Admlnbtrfe-
|or waive thla leqalieiaeat.
(Ill) £/ut<:menf i\f practical treat
tncnt~(A\ TotteUv Cateuaty /• A
jitalcmeni of practical treatment *
buala of oral. Intialailon or dernail t««
Icily. The Agency may. however.
permit reasonable variation* In
placement, of ihe ututemenl of p
cu| ireu|meni lit uome reference
U4 "Bee iitatemeni of practical
mei4 Oi) back |>uiie|" appeaiif on
APPENDIX XV-
-£i»vh;ooni«fifa|
M><*
/
word
front panel near
nad the ttkal) am ..
<)U O//«ci fojcfcff^ cateoorte*. The
jituteaipnt of practical ireuiment IK no(.
reiinhed on the froni panel except a«
described In paragraph (li>(||)(|l|HA> of
ijiiu ueetlon. T|ie appllcani may, how
eyer, Include Much a froni panel aiate-
ineni a| blu option. £l|aLeinenU of
|irucilca| licatmcni are. however, re-
quired eluewherc on ihe Jabel |n
accon| with paragraph (I»HU) of ||iu<
«ecilp{| |f ihey da fiof. appear on M»«
front panel.
(Ivl Wuvtmcnt «)i<| proint'te'tc6- ^H
the require froni pane) wttrM'Otf «la|e
H)cnii( ahull be grouped^ iogellief oil
|ha label, and ahall appear with tinffl'
deni promlnenee relaiiye to other
front panel iexj. and graphic (naier|a|
io iiiuke thcni unlikely |o ho bvvr
|ookei| under cuatoiikury conditions of
purchaae and nan. T|)e following table
4hou/a tin) miik|i|knin |ype al^e rehul| appear |(>gelhe| on
ihe |uhe| under |he general heading
*»JCk.. ..«• '~" • '
In •<>•»<»
fufaU*
I Wfcluul^
i ft kt 10
f
<4
•
+
under appropriate anbheudlnga of
''{lai&ard toTlnmuau und Domcatlc Anl
laula," "(finvlronniental Hazard" and,
'Thyalcul or Chemical Hazard "
(l> llasuttt tit hunmnt untt datmsntic
unimult. M> V^bere a hazard exbla to
'. hnmun.A or domestic uabaula. precan-
fjonary uluteiiteata are required hull
eating ihe puiilcnlur hazard, ihe
ronlefu) af exposure and ihe piecun
iionu |p be taken io avoid aficldeni.
Injury or Damage. The'precunilonury
paragraph ahull bu Immediately pie
Cede*) by i|»e appropriafe hazard ulnina!
wortl.
(L|l | ||c follotvlng table dcpjcfa iypl
eal precanilonary tdutcntentd. Theuo
litateiaeniu miiai he modiflei| or ex-
panded io fccflcct upeciffc '
-------
I 14210
4ioiut fa ayofd potential uccidciif..
Injury or damage. ftxumnleu of tha
iut/ard /tUatementa and Jha c|rcnm
aianccti under which they arc required
follow: '
(4* If a. pcuticldi) Intended fur out
door into cnnialnu an active Ingredient
with a mammalian acute oral I-P« of
100 or leua. flic /statement "Tb»a Pa4|-
clde la Toxlu (o Wildlife" In re If a pcbtlcldu Intended fur out-
door UMU contalnfi an active Ingredient
with an avlan ucnto oral 1.1X. of 100
mu/kg or Icsa. or a mihucutc dietary
I.C.. nl 6()Q ppm or |euu. the iiiutcmcnt
"Thlu Vcfitlolde Id Toxic to Wildlife" I*
40 — f rotation of
If either accident |i|"tory or f|eld
j« demonatraio that Had of the.
pctdicfde |itay reau|t in fatality to
fdrda. flat) or mamiuula. |he utatenient
•'ThU pesticide |u extremely to«|c to
wildlife (flan)" Is. required.
(BJ) V\>r uucu Involving foliar applica-
tion to agricultural crppu. forettu. or
ahade treed, or (or mouqulio a but a
jnent treatment*. petitlclJen tox|u ta
pollinating |nuecU natat bear appropr)-
L
(I-1) For all outdoor »»ucu other thuri
|>|itltiatlontt tho luhel
tho caution "Keep out of
or uticunkti. |)o |
hy <;|cunlng of encni i\l dlf^ellout /or ute.
iuuy uin>eur on any
of tho lahfil provided that thuy
coikanlciiou« enough to hfi euttlly
by tho uuer of the peullcldu product.
Pliuetlonu for nuu may unncar OH
printed or umiihlo mutter which »c
COin|tunlea thu |teut|cldc provided U>»t:
ttiiyit>i
or clretilatu. uueh an "^
In tho eiu;|Ottet eln;n»ur:"
APPENDIX XV-1
(continued)
that It l<| iu>t
tlons
|.//o»u fa
pf i^fl (A)
lon/t jor |»ue niay bo
l(thc|
of thu |trotluci for
that
only
by
(r««« la pf roiJiickJittf
ttiuletl •pftclll^a the ty
of
lor
Itti
a
>
jhiilr itgular |iiaiiMfaptMf{nii
*
(I)TM label cleat |yfl|iow« thttMI»0
product la |nt|s«do4 fof laio Mlly|n« ill*
prodiict in^lved and ita
In
f^tw oninan or tho
, .
U |ltsttdl'»«a
iuit(.iineti in |H4.IU(J> Immedi-
ately nndur the heading "blrectloiu
lor (lae.*'
(||) Immedlutely below thu utale
nient of use clarification, tha alutc
inefil "It Id H vlultttlon u( federal law
to nao thla product fn a manner (neon
ulutcnt with lla luhellng.''
(i|l> Tho tt|te(t) of application, |iu (or
the cro|»4. anlmala, arcua. or
. i
(Iv) Tlie ,-
wltl| eucl) uilu.
(v) The damage rate aaaocluted with
eac^i ulte and peat.
(vi>.T|ie method of application. In
cfndlng inatriu tloua for dilution^ If re
quired, and lypctu) of appllcatfoi) ap
paratua or equfpmcnt required.
(y||) T|ie frequency and timing of ap
plfcutlona neccuaary to obtain eflecttvo
feaulta without caiiiiing nnreuuonuble
atlvcruc effects on the environment.
(vllH tipeclfic limititllona on reentry
to arcaa where the peatlclde haa heun
"' * the re
-------
?W2.IT
or s
in* type of the same
as requirsd for the child hazard *am-
te* (See-Toole in I lS2.H3-
uiwsse effects, such as
(A3 HejTUiresl intervals. between- ap~
giicirtoa. and: inn-ess; oi food or feed;
crocs. '
(35 Hotational Crop -^ jMjf^ [i^rirtn^
(C3 Warnings' as- required. ^^ir^r- us*
Qtt i'1^*'*^-^' 'T'JftV arv-rpftj^, OOJeCtS, OF
iZL or. adjacent co f^ya.i'n ^r»«5t_
CBeserveoI
• (23 Baxr restricted. use pesticides; a.
may ^ft-
under tn« dir
£ ccrtllled icciicaxor •yn
<««*ny -pjresent ax g^^
aoc
co iiie
liis
Agency aaa detarztined. cn&£- thts '
«> aaay only o* a?5iied under"
tna dines ^uperrunon o^ a. csrttfled ao-
^ilffyfrOf ?&o is pJiyBic*!"*? pT5ssdtt
C?T Ctixer 5«rtinenr iniornadon;
^ r-JTrnn T^CT^^'T' ' dfiCSZ^Si
o«r n
ry for tne procecrtfln oi
man. and. i&e
(43- Stntrment of
37 Gcaater 22. LS7S, ail acaticidfi prod-
acts anss i»ar on :neir iaieia i staw-
rp*m±>. oi 11S»» r» t a^gfi f 1 d^l OTt 23-
in Baragrapns (JX1J and (25 oi tnis
fi«7f^ Any pesticide orodTic- for
y?m«? user are
otnerr for
'or ^anerai
us«
o«-
laaeied accortlins w ciie
standards- sec fartii in snis
be staxitawd as
rate products- . product has both re-
ssrtctad uselrai1 ^e SUhjCCS. tO
ot i 1JS2JJKJ3<23.
dde- products, bearins: dirscHons: for
useis) dassiiied general 5 hail be la-
beled. with She £3cact words- "General.
Glassilicaiion" Lrcnaediateiy beiow ihe-
heading "Directions for (jse." And ref-
eranca- co the- general ciassillcasion
• ^*g 5U«jeats- or implies that- ;he gen-
srai oaitty oi ihe pesticide, extends.
beyond those purrroses and uses can
•Gained- in ihe Directions for Use -anil b«
considered a false or misleading stz^S-
T^«»nt under the stasutory 'i<»f^7ii'Ti/7Ttg
oi misaranoinsi
Us* Clsssiftc&tian.
products bearing direction
for use relative
ta other f-""*^ ajid graphic Tra^Tt^11 on
the front panel to- -**±» it itniife^y to-
be overlooked, under customary condi-
tions oi purchase, and use. the .state-
ment. '
aapear,
(33 Directly beio^ t*r«. statement ojr
the front panel, a summary gr?*:-a*n**ifT'
oi the terms oi :eaa'*ct4.nn: imposed, ast
a. precondition to registration shall
appear. II asa is restricted to certified.
applicators; the folio-wan^ statement ^
required: ""For rstau\ sale to and use
only by Carrliled Applicators- or per-
sons under their direct supervision and.
only for those uses covered by the Car-
tifled Applicators certtCeaticn." U,
howererr other regulatory rsstrtctions
axe imposed, the Administrator Trtil
^i»^Tig cae appropriate- warding far the
terms oi restriction by regulation.
(3cj Advertising GlsserresU
C40 7S
Au*. L
July 3. 1373:
43 ?H 5738. ?s
40 ?"S' 32353.
21. 137S. 33
13733
-------
APPENDIX IV-2
LABELING REQUIREMENTS OF THE FIFRA, AS AMENDfclD (REFER TO THE SAMPLE LABELS FOLLOWING)
ITFM
1
2
3
4
5
6A
6B
7
7A
7B
tABEL ELEMENT
Product name
Company name
a iid address
Net contents
EPA Est. No.
EPA Reg. No.
Ingredients
statement
Pou nds/ga 1 Ion
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word ,
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where dosage
given as Ibs.
ai/unit area
All products
All products
All products
PLACEMENT
REQUIRED
Front panel
None .
None
None
None
Front panel
Front panel
Front panel
Front panel
Front panel
ON LABEL
PREFERRED
Center front
panel
Bo t tan front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel,
immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the iiia in
ingredients
statement
Above signal
word
Immediately
below child
hazard
warnirKj
.'
COMMENTS -
,i
If registrant is not the producer, must
be qualified by "Packed for . . ./'
"Distributed by. . . ," etc.
'May be in metric units in addition to
U.S. units
•^
Must be in similar type size and run
parallel to other ^iy]je.
May appear on the container instead of
the label.
Text must run parallel with other text
on the panel.
All frpnt panel precautionary statements
must be grouped together, preferably
blocked.
Note type size requirements.
Note type size requirements.
-------
APPENDIX IV-2 (continued)
ITfcM
7C
LABEL ELEMENT
APPLICABILITY
OF REQUIREMENT
PLACEMENT ON LABEL
REQUIRED
PREFERRED
COMMENTS
Skull & cross-
bones and word
POISON (in red)
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxicity
Front panel
Both in close
proximity to
signal word
7D
Statement of
practical
treatment
All products
in Categories
I, II, and III
Category Is
Front panel
unless refer-
ral statement
is used.
Others;
Grouped with
side panel
p reca u t i ona ry
statements.
Front panel
for all.
7E
8
8A
8B
Referral
statement
Side/back panel
precaut ionary
statements
Hazards to
hunans and
danestic
animals
Environmental
hazards
All products
where pre-
cautionary
labeling
appears on
other than
front panel
Front panel
All products
None
Top or side
of back panel
preceding
directions
for use
Must be grouped under the headings in
8A, 8B, and 8C; preferably blocked.
All products
in Categories
I, II, and III
None
Same as above
Must be preceded by appropriate signal
word.
All products
None
Same as above
Environmental hazards include bee
caution where applicable.
-------
APPENDIX W-2 (continued)
ITEM
ttC
9A
9C
10A
IOC
10D
U.S.
[ABEL ELEMENT
Physical or
chemical
hazards
Restricted
block
Mi suse
statement
Re-entry
statanent
Storage and
disposal block
Directions
tor use
APPLICABILITY
OF REQUIREMENT
All pressurized
products, others
with flash
points under
150°F
All restricted
products
All products
All
cholinesterase
inhibitors
All products
All products
PLACEMENT ON IABEL
REQUIRED
None
Top center
of front
panel
Immediately
following
statement of
classifica-
tion or
ahead of
directions
for use
In the
directions
for use
In the
directions
for use
None
PREFERRED
Same as above
Preferably
blocked
-
Immediately
after misuse
statanent
Immediately
before
specific
directions
for use or
at the end of
directions
for use
None
•!.. COMMENTS
,j
Includes a statanent of the terms of
> restriction. The words "RESTRICTED USE
PESTICIDE" must be same type size as
signajl word.
Must be set apart and clearly distin-
guishable from from other directions
for use.
i
May be in metric as well as U.S. units
-------
Appendix IV-3
PHYSICAL-CHEMICAL HAZARDS
Criteria
I. Pressurized Containers
A. Flashpoint at or below
20 "F; or if there is a
flashback at any valve
opening.
B. Flashpoint above 20 "F
and not over(80aF; or
if the flame extension
is more than 18 inches
long at a distance of
6 inches from the
valve opening.
C. ALL OTHER PRESSURIZED
CONTAINERS
II. Non-Pressurized Containers
A. Flashpoint at or below
20°F.
B. Flashpoint above 20 "F
and over 80°F.
C. Flashpoint over 80*F
and not over 150aF.
D. Flashpoint above
150aF.
Required Label Statement
Extremely flammable.
Contents under pressure.
Keep away from fire/ sparks,
and heated surfaces. Do not
puncture or incinerate
container, Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat/ sparks, and flame. Do
not puncture or incinerate
container. Exposure to
tamperatures above 130 aF
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do•not
puncture or incinerate
container. Exposure to
temperatures above 13Q.aF
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
-------
Appendix IV-5
STORAGE AND DISPOSAL INSTRUCTIONS FOR PESTICIDES
All products are required to bear specific label instructions
abou^ storage and disposal. Storage and disposal instructions
must oe grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need not include the heading
"STORAGE AND DISPOSAL." The STORAGE AND DISPOSAL heading
must appear in the minimum type size listed below:
I Size of label
T front panel"in -
I square inches
Required type size
for the heading
STORAGE AND DISPOSAL'
(all capitals)
10 and under .
Above 10 to 15
Above 15 to 30
Over 30. . . .
.6 point
.8 point
10 point
12. point
Storage and disposal instructions must be set apart and
clearly distinguishable from other directions for use.
Blocking storage and disposal statements with a solid line is'
suggested as a means of increasing their prominence.
A. Storage Instructions:
All product labels are required no have appropriate storage
instructions. Specific storage instructions are not prescribed
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors:
1. Conditions of storage that might alter the composition or
usefulness of the pesticide. Examples could be temperature
extremes, excessive moisture or humidity, heat, sunlight,
friction, or contaminating substances or media.
2. Physical requirements of storage which might adversely
affect the container of the product and its ability to
continue to function properly. Requirements might include
positioning of the container in storage, storage or .damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
3. Specifications for handling the pesticide container,
including movement of container within the storage area,
proper opening and closing procedures (particularly for
opened containers), and measures to minimize exposure
while opening or closing container.
-------
Appendix IV-5
(continued)
4. Instructions on what to do if the container is damaged in
any way, or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs
5. General precautions concerning locked storage, storage in
original container only, and separation of pesticides
during storage to prevent cross-contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original container and"placement in
locked .storage areas.
B. Pesticide Disposal Instructions:
V
The label of all products, except those intended solely for
domestic use, must bear explicit instructions about pesticide
disposal. The statements listed below contain the exact wording
that must appear on the label of these products:
1. The labels of all products, except domestic use, must
contain the statement, "Do not contaminate water, food,
or feed by storage or disposal."
2. Except those products intended solely for domestic use,
the labels of all products that contain active ingredients
appearing on the "Acutely Hazardous" Commercial Pesticide
Products List (RCRA "E" List) at the end of this appendix
or are assigned to Toxicity Category I on the basis of
oral or dermal toxicity, skin or eye irritation potential,
or Toxicity Category I or II on the basis of acute inhala-
tion toxicity must bear the following pesticide disposal
statement:
"Pesticide wastes are acutely hazardous. Improper dis-
posal of excess pesticide, spray mixture, or rinsate is
a violation of Federal Law. If these wastes cannot be
disposed of by use according to label instructions,
contact your State Pesticide or Environmental Control
Agency, or the Hazardous Waste representative at the
nearest SPA Regional Office for guidance."
The labels of all products/ except those intended for
domestic use, containing active or inert ingredients
that appear on the "Toxic" Commercial Pesticide Products
List (RCRA "F" List) at the end of this appendix or
presently meet any of the criteria in Subpart: C, 40 CFR
261 for a hazardous waste must bear the following pesticide
disposal statement:
-------
3.
Appendix IV- 5
(continued)
"Pesticide wastes are toxic. Improper disposal of excess
pesticide, spray mixture, or rinsate is a violation of
Federal Law. If these wastes cannot be disposed of bv
use according to label instructions, contact your StaLe
Pesticide or Environmental Control Agency, or the Hazardous
Waste representative at the nearest SPA' Regional Off^c*
for guidance . "
Labels for all other products, except those intended for
domestic use, must bear the following pesticide disposal
statement:
"Wastes resulting from the use of this product may be
disposed of on site or 'at an approved waste disposal
facility." " _
Products intended for domestic use only must bear the
following disposal statement: "Securely wrap original
container in several layers of newspaper and discard in
trash . "
G. Container Disposal Instructions
The label of each product must bear container disposal
instructions appropriate to the type of container.
1. All products intended for domestic use must bear one
of the following container disposal statements :.
Container Type
Statement
Non-aerosol products1Do not reuse container(bottle,can,jar).
(bottles, cans, jars)! Rinse thoroughly before discarding in trash
Non-aerosol products
(bags)
Do not reuse, bag. Discard bag in trash.
Aerosol products
Replace cap and discard containers in
trash. Do not incinerate or puncture.
2. The labels for all other products must bear container disposal
instructions, based on container type, listed below:
Container Type
Statement
Metal
containers
(non-aerosol)
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or by
other procedures approved by state and local
authorities.
Plastic containers
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or
incineration, or, if allowed by s-ate and
local authorities, by burning.
stav out of smoke.
If burned,
Glass containers
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved state and local procedures .
-------
Appendix IV-5
(continued)
Container Type
rums
Statement.
UJ.UKIS i Completely empty liner by shaking and I
liners , tapping sides and bottom"to loosen clinging I
j particles. Empty residue into application i
j equipment. Then dispose of liner in a I
sanitary landfill or by incineration if !
I allowed by state and local authorities. i
! If drum is contaminated and cannot be i
__ reused-S dispose of in the same manner. i
I Paper ^ and \ completely empty bag into application I
[plastic bags ! equipment. Then dispose of empty bag in !
1 I a sanitary landfill or by incineration, I
i I or,^ if allowed by State and local I
I i authorities, by burning. If burned, stay 1
j I out of smoke. J
I Compres"sed~" gas ' 1^-Return empty cylinder for "reuse (or I
1 cylinders .{" similar wording). J*
^Manufacturer may replace this phrase with one indicating whether
and how fiber drum may be reused.
2. The labels for all other products must bear container
disposal instructions, based on container type, listed
on the first page of this Appendix.
-------
Appendix IV- 5
(continued)
Pesticides that, ara hazardous wastes under 40 CFR 261. 33 (e) and (f)
when discarded.
"Acutely Hazardous" Commercial Pesticides (RCHA "E" List)
Ingredients , (no inerts ) ;
Acrolein
Aidicarb
Aldrin
Aliyl alcohol
Aluminum phosphide
~4-Aminopyrici"ine '
Arsenic acid
' Arsenic pent oxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p-Chloroaniline
Cyanides (soluble cyanide salts, not specified elsewere)
Cyanogen chloride
2-Cyclohexyl-4, 6-dinitrophenol
Dieldrin
0,0-Diethyl S-C2-ethylthio) ethyl] phosphorodithioate
(disulfoton, Di-Syston)
0,0-Diethyl 0-pyrazinyl phosphorothioate (2inophos)
Dimethoate .
0,0-Dimethyl 0-p-nitrophenyl phcsphorothioate (methyl parathionj
4, 6-Dinitro-o-cresol and salts
4, 6-Dinitro-o-cyclohexylphenol
2,4 Dinitrophenol
Dinoseb
Endosulfan
Endothall
Sndrin
Famphur
Fluoroacetamide
Heptachlor
Hexanethyl tetraphosphate
Hydrocyanic acid
Hydrogen cyanide
Methomyl
alpha-Naphthyithiourea (ANTU)
Nicotine and salts
Octame thy Ipyrophosphor amide (OMPA, schradan;
Parathion
-------
Appendix IV-5
(continued)
"Acutely Hazardous" Commercial Pesticides (RCHA "S" List.)
Active Ingredients continued:
Phenylmercurie acetate (PMA)
Phorate
Potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
Strychnine and salts
.,0, 0, 0, Q-Tetraethyl dithiopyrophosphate (sulfotepp)
Tetraethyl pyrophosphate
Thallium sulfate
Thiofanox
Toxaphene
Warfarin
Zinc phosphide
There are currently no inert ingredients for commercial pesticides
on the "Acutely Hazardous" List (RGRA'"2" List).
-------
Appendix IV-5
(continued)
"Toxic" Commercial Pesticide Products (RCRA "F" List.)
Actiive Ingredients ;
Ace-tone
Acrylonitrile
Amitrole
Benzene
Bis (2-ethylhexyl )pthalate
Cacodyiic acid
Carbon tetrachloride
Chloral (hydra-He)
Chlordane (technical)
Chlorobenzene
4-Chloro-ni-cresdl
Chloroform
o—Chlorophenol
4-Chloro-o-toluidine hydrochloride
Creosote
Cresylic acid
Cyclohexane
Decachlorooctahydro-1, 3, 4-metheno-2H-cyclobu-taCc/d]-oentalen-2-one
(kepone, chlordecone)
1,2-Dibromo-3-chloropropane (DBCP)
Dibu-tyl ph-thala-te
S-3, 3-(Dichloroallyl diisopropylthiocarbaraate (diallare, Avadex)
o-Dichlorobenzene
p-Dichlorobenzene
Dichlorodifluoromethane (Freon 12®)
3,5-Dichloro-N-(l/l-dimethyl-2-propynyl) benzamide (pronamide,Kerb)
Dichloro diphenyl dichloroethane (ODD)
Dichloro diphenyl trichloroethane (DDT)
Dichlorethyl eHher
2,4-Dichlorophenoxyacetic, esters and salts (2,4-D)
1,2-Dichloropropane
1,3-Dichloropropane (Telone)
Dimethyl phthalate
Sthyl acetate
Ethyl 4,4'-dichlorobenzilate (chlorobenzilate)
Ethylene dibromide (EDB)
Ethylene dichloride
Sthylene oxide
Formaldehyde
Furfural
Hexachlorobenzene
Hexachlorocyclopentadiene
Hexachloroethane
Hydrofluoric acid
-------
Appendix IV-5
(continued}
"Toxic" Commercial Pesticide Produces (RCRA "F" List)
Active Ingredients:
Isobutyl alcohol
Lead acetate
Lindane
Maleic hydrazide
Mercury
Methyl alcohol
Methyl bromide
Methyl chloride
2,2* -Methylenebis (3,4,6-trichlorophenol) (hexachlorophene)
^Methylene chloride
Methyl ethyl ketone
4-Methyl-2-pentanone((methyl isobutyl ketone)
Naphthalene
Nitrobenzene
p-Nitropheno1
Pentachloroethane .
Pentachloronitrobenzene (?CNB)
?«ntaclorophenol
Phenol
Phosphorodithioic acid, 0,0-diethyl, methyl ester
Propylene dichloride
Pyridine
Resorcinol
Safrole
Selenium disulfide
Silvex
1,2,4,5-Tetrachlorobenzene
1,1,2, 2-Tetrachioroethane
Tetrachioroethy1ene
2,3,4,6-Tetrachlorophenol
Thiram
Toluene
1,1,1-Trichloroethane
Trichloroethylene
Trichloromonofluoromethane (Freon 11®)
2,4,5-Trichlorophenol
2,4,6-Trichlorophenol
2,4,5-Trichlorophenoxyacetic acid (2,4,5-T)
Xylene
-------
f «*** f^i V^ "^ '? "^ 9 "-* -2f 4'^ *"•
V WWfei ^C^DiitaiS^ /
"Toxic" Commercial Pesticide^Products
Inert Ingredients ; --—-—<»»..
Acetone
Acenonitrila
Acatophenone
Acrylic acid
Aniline
Benzene
Chlorobenzene
Chloroform
Cyclohexane
Cyclohexaiibne "
Dichlorodifluororaethane (Freon 12®)
Die-thyl phthalate
Dimethylamine
Dimethyl phthalaHe
1,4-Dioxane
Ethylene oxide
e
Methyl alcohol (methancl)
Methyl ethyl ketone
Methyl methacrylate
Naphthalene
Saccharin and salts
Thiourea
Toluene
1/1,1-Trichloroethane
1,1,2-Trichloroethane
Trichlorofluoromethane (Freon 11'
Vinyl chloride
Xylene
------- |