v>EPA
            United States
            Environment*! Protection
            Agency
              Off ic« of Pesticides and
              Toxic Substances
              Washington. DC 20460
EPA 560/7-81411
July 1981
            Toxic Substances
Environmental and
Health Aspects of
Chloroform
            A Comprehensive
            Bibliography of Published
            Literature

            1930- 1981

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&EPA
            United States
            Environmental Protection
            Agency
              Office of Pesticides and
              Toxic Substances
              Washington, DC 20460
OTS-TIC REPORT FILE

  EPA 68-01-6021 Rept A
  July 1981
            Toxic Substances
Environmental and
Health Aspects of
Chloroform
            A Comprehensive
            Bibliography of Published
            Literature

            1930- 1981

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50272-101
 REPORT DOCUMENTATION  ;.i._ REPORT NO.
 	PAGE	I EPA  560/7-81-011
                                                                         3. Recipient's Accession No.
 4. Trtle and Subtitle
               Environmental and  Health  Aspects of
  Chloroform,  A Comprehensive  Bibliography,  1930  to
  1981.
5. Report c.te preparation
  June 1981	
 7. Author(s)
                                                                         8. Performing Organization Rept. No.
 9. Performing Organization Name and Address
   Tracer Jitco,  Inc.
   1776 East  Jefferson  Street
   Rockville.,  Maryland  20852
10. Project/Task/Work Unit No.
 Technical  Directive  2
11. Contract(C) or Grant(G) No.
                                                                            68-01-5836
                                                                         (G)
 12. Sponsoring Organization Name and Address
   Environmental Protection Agency,  Office of Pesticides  and
   Toxic Substances, Management  Support Division, 401 M  Street SW,
   Washington,  D.C. 20460
13. Type of Report & Period Covered
 Final Report
 1930-1981
14.
 IS. Supplementary Notes
 16. Abstract (Limit: 200 words)
             This document is a bibliography of published  citations  on health  and
          environmental  aspects of  Chloroform  (Chemical Abstacts Service Registry
          Number 67-66-3) for the period 1930  to May 1981.   The citations have
          been  selected  from a thorough literature search,  and broadly classified
          as  having primarily environmental or  biological  emphasis.   The sources
          used  in the  search are  identified, and for the  portion performed on
          line,  the search strategies are also included.
 17. Document Analysis  a. Descriptors
           Bibliographies; Literature Surveys;  Environments; Public  Health;  Pollution;
           Toxicology.
   b. Identlfiers/Ooen-Ended Terms
           Literature  Search; Literature Review; Health  Effects;  Environmental
           Effects; Chloroform;  67-66-3
   c. COSATI Field/Group
 18. Availability Statement
                                                         ! 19. Security Class (This Report)
           Release unlimited
                                                         i  Unclassified
                                                         | 20. Security Class (This Page)
                                                         '  Unclassified
                                                                                    21. No. of Pages
                                                                                    22. Price
(See ANSI-Z39.1B)
                                         See Instructions on Reverse
          OPTIONAL FORM 272 (4-77)
          (Formerly NTIS-35)
          Department of Commerce

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                               EPA Report No. 560/7-81-011
                               July 1981
      ENVIRONMENTAL AND HEALTH
       ASPECTS OF CHLOROFORM
    A Comprehensive Bibliography
       of Published Literature
             1930  - 1981

                 by

    Management  Support Division
 Information  Support Services Branch
     Office of Toxic Substances
      Washington,  D.C.   20460
             68-06-5836
          Project Officers
   Michael Weaver, Delores Evans

    Management  Support Division
     Office of Toxic  Substances
      Washington, D.C.   20460
     OFFICE OF TOXIC SUBSTANCES
U.S. ENVIRONMENTAL PROTECTION AGENCY
      WASHINGTON, D.C.   20026

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                                    Preface
      This bibliography was created from a literature search performed under
the auspices of the Management Support Division, Information Support  Services
Branch for the Assessment Division, Chemical Review and Evaluation  Branch;
both of the Office of Toxic Substances.  The search was intended  to provide
partial support for the preparation of a Preliminary Risk Assessment  on
chloroform (67-66-3).  This assessment reviews and evaluates the  available
significant economic and adverse effects data from both published and
unpublished sources on a substance selected as being potentially  hazardous to
human health or the environment.

      The subject coverage of the assessment is broader than this bibliography
which includes only published environmental and biological  information.  The
bibliography does not include all information available to  the review branch.
Although it is not an authoritative source list for Preliminary Risk
Assessments, it does represent a comprehensive and systematic search  of  the
literature and subsequent selection of citations that pertain to  health  and
the environment.  The limits of the search are fully described in this
document and its appendices.

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                                 Introduction
1.    The Search

      This bibliography is a compilation of citations retrieved during a
thorough review of the national and international literature on chloroform
(Chemical Abstracts Service Registry Number 67-66-3) cited between 1930 and
April 1980.

      The supporting search was performed at the request of the Assessment
Division/Chemical Review and Evaluation Branch by the Management Support
Division/Information Support Services Branch, within the Office of Toxic
Substances.

1.1.  Scope

      To insure that the search was comprehensive, a variety of sources were
examined, including the following:

      o  On-line databases from major vendors of bibliographic information.

      o  On-line databases from various agencies of the United States
         Government.

      o  Manually searched national and international indices and abstract
         collections of scientific literature.

      o  Reference sections of major review articles, criteria documents,
         monographs, and reports.

      o  Selected handbooks.

      (A complete listing of sources consulted can be found in Appendices I
and II).

      The emphasis of this bibliography is on the primary literature except
for the handbook information presented in Section II and a few secondary
sources selected because they contain unique or well-summarized information on
the chemical.

      Subsequent to the main search, which was completed in April 1980, and
using the same strategy, update searches were performed during the period from
April 1980 to May 1981 on all the on-line databases initially searched.  In
addition, the April 1981 and May 1981 issues of Current Contents (Life
Sciences, Agriculture, Biology, and Environmental Sciences series) were
screened to retrieve citations which may not have been entered into the
on-line files at the time of the final update searches.
                                      11

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      Because the overall requirement of the search request for this project
was broader than the health and environmental aspects of the chemical, a wider
range of databases was searched than might normally be expected for this
bibliography.  However, only health and environmental aspects were selected
regardless of the data source examined.  The total complement of databases
searched is listed in the appendices for the user's reference.

1.2.  Strategy

      The search requirement demanded high recall of information dealing with
chloroform; precision was a secondary consideration.  EPA decided to retrieve
all citations that contained the term chloroform or its synonyms in any
searchable fields and to select relevant citations by a manual screen.  The
Chemical Abstract Service registry number (CAS RN) and systematic names and
synonyms that could be identified from CHEMLINE (National Library of
Medicine); CHEMDEX (System Development Corporation); CHEMNAME, CHEMSEARCH, and
CHEMSIS (Lockheed Information System); SANSS (NIH/EPA Chemical Information
System); and RTECS (NIOSH Registry of Toxic Effects of Chemical Substances)
were used in the search on databases.  For on-line searching, the names were
divided into significant fragments and entered according to the conventions of
the individual databases.
      Chemical terms used in this search were as follows:
         CAS RN:  67-66-3
         CAS ON:  8013-54-5
         chloroform (8CI)
         methane, trichloro- (9CI)
         R20 (refrigerant)
         R20 (VAN)
         trichloroform
         trichloromethane

      No additional modifiers or keywords were used to limit information
retrieved in any database for this chemical because comprehensive retrieval
was desired.  Complete search strategies are listed in Appendix II.

      Use/Application categories were not used as search terms because EPA
decided to select only terms that specifically mentioned the chemical or its
synonyms.  Indexing policy, keyword entry, and abstracting techniques usually
assure retrieval of specific information on individual chemicals if they are
discussed significantly in general articles or reviews.  The user can be
assured, therefore, that each citation listed in this bibliography contains
substantive information on the subject chemical.
                                      ill

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      Manual sources, indices, and abstract collections usually employ their
own unique indexing schemes for chemical information, so it is difficult to
describe a standard search strategy for these information tools.  However, in
all cases, the most specific indexing terms available in the source were used
to identify citations on the subject chemical.

1.3.  Selection of Citations

      Citations were selected for inclusion in this bibliography based on
their relevance to the following topics:

      o  Toxicity — Adverse and toxic effects on any biological systems,
         structural and functional changes in organs and tissues of all
         vertebrate and invertebrate species, test methods used for
         determination of toxicity, and bioassay studies.

      o  Physiology — Absorption, distribution, transport, metabolism, and
         elimination in all species; techniques for measurement of tissue and
         organ residues; interactions with endogenous substances.

      o  Epidemiology — Exposure data, morbidity, and mortality rates for
         general and occupational populations.

      o  Environmental Significance — Environmental distribution in air,
         soil, and water; sources of pollution; ecological effects on
         microorganisms, insects, plants, and wildlife; biodegradation and
         bioconcentration; analytical techniques for sampling and measurement
         in the environment.

      o  Safety, Control, and Regulations — Disposal hazards; Federal, local,
         and international controls, recommendations, and regulations.

      These are the broad specifications for inclusion in this bibliography.
Because any literature selection process involves subjectivity and judgement,
precise definitions are difficult.  The general guiding requirement for
inclusion is that citations must pertain to the biological or environmental
aspects of the chemical.

      The following information is not included in this bibliography:

         news items; brief announcements and Federal Register notices; reports
         of on-going research which have not yet been published or any other
         unpublished information; draft reports; and private communications.

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2.    Organization of Bibliography

      This bibliography is organized into three major sections.

2.1.  Section Titles

         Section I   — Handbook information
         Section II  — Citations from the primary literature
         Section III — Appendices listing specific sources used and exact
         search strategies employed

2.2.  Citation Format

      In Section II citations from on-line and manually searched abstract
collections are arranged alphabetically by author.

      Personal names are entered with the last name first followed by the
first two initials.  Second and third authors' names are separated from the
first author and each other by a semicolon.  Up to three personal names are
used; if there are more than three authors, the remaining are listed as
"et al."

      If an author has written more than one article, citations are arranged
in ascending chronological order.  If authors and date are identical,
citations are arranged alphabetically by title of the article.  Single author
entries are listed first, followed by two, then three author entries.

      Patents are arranged alphabetically by assignee name.

      All government publications are listed by the sponsoring government
agency.  Government or corporate names are written in full form.  No acronyms
are used.  The country of origin is listed first, followed by the
organizational hierarchy of the sponsoring group listed in descending
hierarchical order.  If the performing organization or individual author is
known, they are listed on separate lines below the government sponsor.

         Example:  NIOSH publication:

         United States.  Department of Health, Education and Welfare.  Public
         Health Service.  Center for Disease Control.  National Institute for
         Occupational Safety and Health
         Tracer Jitco, Inc.
         Brown, R.A.; Smith S.S.

      Corporate documents with no specific author are listed in alphabetical
order according to the first significant word of the organization name.

         e.g., DuPont de Nemours, E.I. and Company

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2.3.  Literature Cited

      The following kinds of literature are cited in this bibliography:
journal articles, government reports, patents, organization and corporate
reports, books, manufacturer's literature, conference proceedings, and
dissertations.

      In each case an attempt has been made to supply the user with enough
information so that the hard copy of the document may be easily obtained.

      Journal titles are abbreviated according to the style in the Chemical
Abstracts Service Source Index (CASSI), The American Chemical Society,
Columbus, OH, 1980 and its corresponding guide, Bibliographic Guide for
Editors and Authors, The American Chemical Society, Washington, DC, 1974.

      All foreign titles have been translated into English.  Foreign language
articles are indicated by the appropriate three letter language abbreviation
in parentheses at the end of the source information.

2.4.  Categorization of Citations

      In order to make this bibliography a more useful tool for separate user
groups, most citations are marked with the category code E or H.

         E = Environmental Aspects, i.e., the major content of the document
         pertains to the chemical in the open environment:  its distribution,
         degradation, environmental chemistry and analysis; effect on
         ecosystems; effect on flora and fauna, including laboratory research,
         when emphasis is on environmental considerations rather than
         prediction of human effects, environmental chemistry, and analysis.

         H = Health Aspects, i.e., the major content of the document concerns
         known health effects, predictive laboratory research, and animal
         studies as relates to human health effects, human exposure, and
         epidemiological studies.

      A decision was made based on the abstract, and in some cases the entire
document, to categorize according to what appeared to be the major purpose of
the study.  In a few cases neither category applies.  Those citations were
left unclassified.
                                      VI

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 HANDBOOK




    AND




 DATABANK




INFORMATION

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3.    Handbook and Databank Information
3.1.  Summary Databanks for Health Effects Data          (Information found)

United States.  Department of Health and Human
Services.  Public Health Service.  Center for Disease
Control.  National Institute for Occupational                   yes
Safety and Health
Registry of Toxic Effects of Chemical Substances.
Cincinnati, OH: NIOSH, 1980
United States.  Department of Health and Human
Services.  Public Health Service.  National
Institutes of Health. National Library of Medicine              yes
Toxicology Data Bank.
Bethesda, MD  1980

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3.2.  Handbooks Searched for Health Effects
Source
Location of Information
Browning, E.
Toxicity and Metabolism of Industrial Solvents,
New York:  Elsevier Publishing Co.,  1963
No pertinent
information found
Browning, E.
Toxicity of Industrial Metals.
New York:  Appleton-Century-Crofts,  1969
No pertinent
information found
Dittmer, D.S., Editor
Handbook of Toxicology, V. - Fungicides.
Philadelphia:  W. B. Saunders Company, 1959
No pertinent
information found
Fishbein, L.
Potenial Industrial Carcinogens and Mutagens.
New York: Elsevier Scientific Publishing Co.,  1979
pp. 212-7
Fishbein, L.; Flamm, W.G.; Falk, H.L.
Chemical Mutagens.
New York:  Academic Press, 1970
No pertinent
information found
Goodman, L.S.; Oilman, A., Editors
The Pharmacological Basis of Therapeutics.
New York: Macmillan Publishing Co., Inc.,  1975
p. 96
Patty, F.A., Editor
Industrial Hygiene and Toxicology.
New York:  Interscience Publishers, 1963
pp. 1259-62
Plunkett, E.R.
Handbook of Industrial Toxicology.
New York:  Chemical Publishing Co., Inc., 1976
pp. 101-2
Sax, N.I.
Dangerous Properties of Industrial Materials.
New York:  Van Nostrand Reinhold Co., 1979
p. 493
Searle, C.E., Editor
Chemical Carcinogens.
Washington, DC:  American Chemical Society, 1976
pp. 158-9

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3.2.  Handbooks Searched for Health Effects  (cont'd)
Source

Shepard, T.H.
Catalog of Teratogenic Agents.
Baltimore, MD:  The Johns Hopkins University
Press, 1976
Location of Information

No pertinent
information found
Spector, W.S., Editor
Handbook of Toxicology, V. I. - Acute Toxicities,
Philadelphia:  W. B. Saunders Company, 1956
pp. 68, 328
Spector, W.S., Editor
Handbook of Toxicology, V. II. - Antibiotics.
Philadelphia:  W.B. Saunders Company, 1957
No pertinent
information found
Spector, W.S., Editor
Handbook of Toxicology, V. III. - Insecticides.
Philadelphia:  W.B. Saunders Company, 1959
No pertinent
information found
Sunshine, I., Editor
CRC Handbook Series in Analytical Toxicology.
Boca Raton, FL:  CRC Press, Inc., 1979
pp. 400-1
United Nations.  International Agency for Research on
Cancer
IARC Monographs on the Evaluation of the Carcinogenic
Risk of Chemicals to Humans.
Lyon, France:  IARC
1:61-5
20:401-27
United States.  Department of Health and Human
Services.  Public Health Service.  Center for
Disease Control.  National Institute for
Occupational Safety and Health
NIOSH Criteria Documents.
Cincinnati, OH:  NIOSH
Entire document
United States.  Department of Health and Human
Services.  Public Health Service.  Center for
Disease Control.  National Institute for
Occupational Safety and Health
Registry of Toxic Effects of Chemical Substances.
Cincinnati, OH:  NIOSH, 1980.
p. 411

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3.2.  Handbooks Searched for Health Effects  (cont'd)
Source

United States.  Department of Health and Human
Services.  Public Health Service.  National
Institutes of Health.  National Cancer Institute
NCI Carcinogens Bioassay Reports.
Springfield, VA: National Technical Information
Service
Location of Information
Entire document
United States.  Department of Health and Human
Services.  Public Health Service.  National
Institutes of Health.  National Cancer Institute
Survey of Compounds Which Have Been Tested for
Carcinogenic Activity.
Bethesda, MD:  NCI, 1978
1961-7, pp. 200-2
1978, p. 71
United States. Environmental Protection Agency
EPA Publications Bibliography.
Washington, DC, EPA
77(2):37
78(1):42
79(2):60-1

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3.3.  Handbooks Searched for Environmental Effects
Source

Applegate, V.C.; Ho we 11, J.H.; Hall, A.E.; et al.
Toxicity of 4,346 Chemicals to Larval Lampreys'  and
Fishes:  Special Scientific Report.
Fisheries No. 207, Washington, DC, 1957
Location of Information

No pertinent
information found
McKee, J.E.; Wolf, H.W., Editors
Water Quality Criteria, 2nd Edition.
California State Water Resources Control Board,  1963
p. 163
Ryckman, D.W.; Prabhakara Rao, A.V.S.; Buzzel, J.C.
Behavior of Organic Chemicals in the Aquatic
Environment.
Washington, DC: Manufacturing Chemists' Association,
1966
No pertinent
information found
United States.  Environmental Protection Agency         pp. 69-72
Review of the Environmental Fate of Selected Chemicals.
Springfield, VA: National Technical Information
Service, 1977
United States.  Environmental Protection Agency
Review of the Environmental Fate of 129 Priority
Pollutants.
Springfield, VA: National Technical Information
Service, 1977
Chap. 40,
PP. 1-9
Verschueren, K.
Handbook of Environmental Data on Organic Chemicals,
New York:  Van Nostrand Reinhold Co., 1977
pp. 178-9

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3.4.  Handbooks Searched for Physical and Chemical Properties
Source
Location of Information
Aldrich Chemical Company, Inc.
Aldrich Catalog Handbook of Fine Chemicals.  1981-2.
Milwaukee, WI:  Aldrich Chemical Co., 1980
p. 213
Bennet, H., Editor
Concise Chemical and Technical Dictionary.
New York:  Chemical Publishing Co., Inc.,  1974
p. 240
Dreisback, R.R.
Physical Properties of Chemical Compounds.
Washington, DC: American Chemical Society, 1959
p. 196
Grasselli, J.G.; Ritchey, W.M., Editors
CRC Atlas of Spectral Data and Physical Constants
for Organic Compounds.
Boca Raton, FL:  CRC Press, 1975
Vol. Ill, p. m-381
Grayson, M., Editor
Kirk-Othmer Encyclopedia of Chemical Technology.
New York:  Interscience Publishers, 1979
Vol. II, p. 397
Vol. V, pp. 92-4,
97-8, 119-27
Hawley, G.G.
The Condensed Chemical Dictionary.
New York:  Van Nostrand Reinhold Co., 1977
p. 197
Kortum, G.; Vogel, W.
Dissociation Constants of Organic Acids in Aqueous
Solution.
London:  Butterworths, 1961
No pertinent
information found
Leo, A.; Hansch, C.; Elkins, D.
Chemical Reviews.
Claremont, CA: Department of Chemistry, Pomona
College, 1971
p. 555
Linke, W.F.
Solubilities of Inorganic and Metal-Organic
Compounds.
New York: D. Van Nostrand Co., Vol. I. 1958,
Vol. II. 1965
No pertinent
information found

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3.4.  Handbooks Searched for Physical and Chemical Properties   (cont'd)


Source                                                  Location of Information

Mark, H.F.; Gaylord, N.G.; Bikales, N.M., Editors       No pertinent
Encyclopedia of Polymer Science and Technology.          information found
New York: Interscience Publishers, 1964
Perry, R.H.; Chilton, C.H., Editors                     pp.  210-4
Chemical Engineers Handbook.
New York:  McGraw-Hill Book Co., 1973
Pollock, J.R.; Stevens, R., Editors                     p.  627
Dictionary of Organic Compounds.
London:  Eyre and Spottiswoode Publishers, Ltd.,  1965
Stephen, H.; Stephen, T.; Editors                       No pertinent
Solubilities of Inorganic and Organic Compounds.         information found
New York:  The Macmillan Co., 1963
Weast, R.C., Editor                                     p.  375
CRC Handbook of Chemistry and Physics.
Boca Raton, FL:  CRC Press, 1979
Windholz, M., Editor                                    p.  272
The Merck Index.
Rahway, NJ:  Merck and Co., Inc., 1976

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 CITATIONS




 FROM THE




LITERATURE

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    Abajian, J.; Brazell, E.
H   Refractory Period and Conduction Time Studies with Ethyl  Ether,
    Cyclopropane, and Chloroform Using Turtle Ventricle Strips.
    Fed. Proc., 10(1):275 (1951)
    Abelin, I.
H   Adrenal Function and Cholesterol Metabolism in Narcosis.
    Helv. Physiol. Pharmacol. Acta., 4:1-9 (1946)
    Abreu, B.E.; Auerbach, S.H.;  Thuringer,  J.M.;  et al.
H   Chronic and Delayed Toxic Effects of Certain Saturated and
    Unsaturated Halogenated Hydrocarbons in White  Rats and White
    Mice.
    J. Pharmacol. Exp. Therap., 80:139-45 (1944)
    Acierno, L.J.; DiPalma, J.R.
H   The Effects of Ether, Cyclopropane,  and Chloroform on the
    Isolated Auricle of the Cat.
    Anesthesiology, 12:567-73 (1951)
    Adams, W.L.
    The Determination of Chloral Hydrate,  Chloroform,  and Related
    Substances in the Blood.
    J. Pharmacol. Exp. Ther., 74:11-7 (1942)
    Adey, G.D.; Williamson, F.B.
H   The Mechanism of Action of Anaesthetic Agents;   A Model
    Simulating Enzyme Catalysis.
    Br. J. Anaesth., 51(6):565-6 (1979)
    Adey, G.j Wardley-Smith, B.; White, D.
    Mechanism of Inhibition of Bacterial Luciferase by Anaesthetics,
    Life Sci., 17(2):1849-54 (Dec. 15, 1975)
    Adriani, J.; Rovenstine, E.A.
H   The Effect of Anesthetic Drugs upon Bronchi and Bronchioles  of
    Excised Tissue.
    Anesthesiology, 4:253-62 (1943)
    Afghan, B.K.; MacKay, D. (eds.)
    Hydrocarbons and Halogenated Hydrocarbons in the Aquatic
    Environment.  New York:  Plenum Press, 1980
                                 11

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    Agostino, D.; Cliffton, E.E.
H   Anesthetic Effect on Pulmonary Metastases in Rats.   Development
    of Metastases of Walker 256 Carcinosarcoma.
    Arch. Surg. (Chicago), 88:735-9 (May 1964)
    Agustin, J.S.; Lim-Sylianco, C.Y.
H   Mutagenic and Clastogenic Effects of Chloroform.
    BullT Philipp. Biochem. Soc., l(2):17-23 (1978)
    Ahmad, M.M.; Jahangeer, S.; Mir,  A.K.
H   Effect of Different Anesthetics on Plasma Glucose Levels in
    Uromastyx hardwickii Gray.
    Biologia (Lahore), 23(1):17-21 (1977)
    Ahmed, A.E.; Kubic, V.C.; Anders, M.W.
H   Metabolism of Haloforms to Carbon Monoxide.   I.   In Vitro
    Studies.
    Drug Metab. Dispos., 5(2):198-204 (1977)
    Ahmed, S.M.; Gupta, M.R.
H   Stabilization of Pyrethrins for Prolonged Residual Toxicity.
    Part I;  Screening of Various Ingredients.
    Pyrethrum Post, 13(3):82-8 (1976)
    Ahr, H.J.; King, L.J.; Nastainczyk,  W.;  et al.
H   The Mechanism of Chloroform and Carbon Monoxide Formation from
    Carbon Tetrachloride by Microsomal Cytochrome P-450.
    Biochem. Pharmacol., 29(20):2855-61  (1980)
    Ai, N.; Takagi, S.F.
H   The Effect of Ether and Chloroform on the Olfactory Epithelium.
    Jpn. J. Physiol., 13(5):454-65 (Oct. 15,  1963)
    Alavanja, M.; Goldstein, I.; Susser, M.
H   A Case Control Study of Gastrointestinal and Urinary Tract
    Cancer Mortality and Drinking Water Chlorination.
    Water Chlorination, 2:395-409 (1978)
    Al-Azzawi, H.T.; Steward, P.J.
H   The Effects of Lethal Procedures on the Histochemical
    Localization of Acid Hydrolases.
    Histochemie, 37(2):187-95 (Oct. 26, 1973)
                                 12

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    Albert, R.E.; Burns, F.J.; Altshuler, B.
H   Reinterpretation of the Linear Nonthreshold Dose-Response Model
    in Terms of the Initiation-Promotion Mouse Skin Tumorigenesis.
    In:  Advances in Modern Toxicology.  Vol. 1.  New Concepts in
    Safety Evaluation.  Part 2.  Edited by Melman, M.A.;  Shapiro,
    R.E.; Blumenthal, H. Washington, DC: Hemisphere Publishing
    Corp., pp. 89-95, 1979
    Alcala, H.; Lertratatanangkoon, K.; Stenbach, W.
H   The Purkinje Cell in Dilantin Intoxication; Ultrastructural and
    Golgi Studies Preliminary Report.
    Symposium: Epilepsy International Symposium.
    Vancouver, Canada, 1978.
    In: Advances in Epileptology. Edited by Wada, J.A.;  Penry, J.K.
    New York: Raven Press, pp. 519, 1980
    Aldridge, M.H.; Pressley, T.A.;  Chapin, C.;  et al.
    Characterization of Nonvolatile Organic Material during
    Physical-Chemical Treatment of the District  of Columbia Raw
    Wastewater.
    U.S. NTIS, PB-280267, 34 pp. (1976)
    Alekhina, R.P.; Piker, E.G.; Likhtenshtein,  A.V.
H   Losses of Nucleic Acids of Animal Origin in the Process of Their
    Deproteinization by Phenol and Chloroform.
    Bioklhimiia, 38(4):779-84 (Jul.-Aug. 1973)
    Alekseev, A.E.
H   Significance of the Central Nervous System in Pharmodynamics of
    Some Vapor-Phase Drugs Administered in Respired Air.
    Farmakol. Toksikol., 18(6):22-4 (1955)
    Alexsanderov, I.S.
H   Alteration of the Eye-Heart Reflex under Influence of Narcotics.
    Fiziol. Zhur., 37:64-8 (1951)
    Alha, A.; Korte, T.
H   Gas Chromatographic Determination of Drugs in Post-Mortem Blood.
    Ann. Med. Exp. Biol. Fenn., 50(4):175-9 (1972)
    Allen, J.G.; Kable, V.; Livingston, H.M.
H   Effects of Anesthetic Agents on Prothrombin Concentration.
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                                 25

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                                 44

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                                 46

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                                 01S-1IC REPORT FILE
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H   Comparative Description of Some Anesthesia Types Based on Data
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H   Initial Results of the Clinical Use of Epontol Anesthesia.
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H   Anesthesia in War and Peace.  Recent Developments.
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H   Effect of Ciliary Movements of Some Agents Which Come in Contact
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H   Studies in Lipoid Metabolism.  I.  Variation in Cholesterol
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                                 71

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    Dautrebande, L.
H   Some Recent Developments in the Field of Anesthesia.
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H   A Technique for the Determination of Blood Levels  of  Halogenated
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H   A Method of Gas Chromatography Using Electron-Capture  Detection
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    Br. J. Anaesth., 50(2):147-55 (1978)
    Davies, D.D.; Mathias,  J.A.
H   A Method for the Determination of Residual Quantities  of
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    Br. J. Pharmacol., 40(3):596 (Nov. 1970)
    Davis, D.D.; Watson, R.;  McGee,  T.;  et al.
    Tropospheric Residence Times for Several Halocarbons  Based  on
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E   Effects of Organic Solvents on Growth and  Ultrastructure  of
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    Pestic. Biochem. Physiol.,  8(1):84-97 (1978)
    Davis, D.L.; Magee, B.H.
H   Cancer and Industrial Chemical Production.
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H   The Effect of Anesthetic Agents on Evoked  Central Nervous  System
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                                 72

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    Davison, M.H.A.
H   Chloroform.
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H   Our Experience with the Use of Chloroform,  a Current
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H   Corticoadrenal Insufficiency and the Syncope of Chloroform and
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H   The First Delayed Chloroform Poisoning.
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                                 73

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    Deinzer, M.; Schaumburg, F.;  Klein,  E.
H   Environmental Health Sciences Center Task Force Review on
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H   Anesthetic Potency Determined by Depression of Synaptic
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H   Chloroform-Adrenalin (Epinephrine) Induced  Ventricular
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                                 74

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    Delia Mora, R.; Vazquez, A.; Bastaroli,  J.C.;  et al.
H   Chloroform-induced Respiratory Arrest and a Possible  Method  for
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    The New Orleans Drinking Water Controversy.   A Statistical
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    Am. J. Public Health, 65(10):1060-2 (1975)
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H   Relationships between Cancer Mortality in Louisiana
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    Ozone Depletion Estimates for Global Halocarbon and Fertilizer
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    Halocarbon Lifetimes and Concentration Distributions Calculated
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    Atmos. Environ., 12(6-7):1261-9 (1978)
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H   Long Term Safety Studies of a Chloroform Containing Dentifrice
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    Food Cosmet. Toxicol., 13(5):529-32 (Oct. 1975)
                                 75

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    Desmonts, J.M.;  Mignon,  F.;  Hennetier,  G.;  et  al.
H   Anesthesia in the Course of  Acute Renal Insufficiency.
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H   Irregularities of Pulse and Contraction of Right  Ventricle
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    Dethier, V.G.; Goldrich-Rachman,  N.
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    Devlin, R.M.; Kisiel,  M.J.;  Kostusiak,  A.S.
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    Dewalle, F.B.; Chian,  E.S.K.
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    Proceedings:  34th Industrial Waste Conference.
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    Dewey, W.L.; Martin, B.R.;  Bagshaw,  B.
H   The Effects of Organic Water Contaminants on Catecholaminergic
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    Toxicol. Appl. Pharmacol.,  45(1):328 (1978)
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    Br. J. Anaesth., 47(4):516-9 (1975)
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    Dhillon, K.S.; Paul, B.S.
H   Effect of Chloroform Anesthesia on Dogs.
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    The Distribution of Short-Chain Halogenated Aliphatic
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    Mar. Pollut. Bull., 7(9):167-9 (1976)
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    Determination of Chlorinated Hydrocarbons in Water by Head3pace
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    Dietz, F.j Traud, J.
    Determining Low Molecular Weight Chlorinated Hydrocarbons  in
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    Dilley, J.V.; Chernoff, N.;  Kay, D.;  et al.
H   Inhalation Teratology Studies of Five Chemicals in Rats.
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H   Action of Camphor-oxime on Frog's Heart in Normal and Depressed
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H   The Effects of Aliphatic Halogenated Hydrocarbons  on Hepatic
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                                 77

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    Di Paolo, T.; Kier, L.B.; Hall,  L.H.
H   Molecular Connectivity and Structure-Activity Relation of
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    Mol. Pharmacol., 13(l):31-7 (1977)
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H   Endoanesthetic and Narcotic Activity in Halogenated Methane
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H   Fluothane and Other Nonexplosive Halogenated Hydrocarbons  in
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H   Changes of Bioelectrical Activity of Cerebral Cortex of Rats
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    Eksp. Khir. Anesteziol., 18(6):72-5 (Nov. - Dec. 1973)  (Rus)
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H   Changes in the Impedance and Bioelectrical Activity of the
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H   Historadiographic Study of the Distribution of Anesthetics
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    Khim. Farm. Zh., 12(8):10-3 (1978) (Rus)
                                 78

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    Dmitrieva, N.V.; Nizhnii, S.V.; Novikova, N.P.; et al.
H   Historadiographic Study of the Distribution of Narcotics between
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H   Enflurane (Ethrane) and Isoflurane (Forane);  A Comparison with
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E   Los8 of Midgut Alkalinity in Chilled or Narcotized  Mosquito
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    Ann. Entolmol. Soc. Am.,  62(2):248-54 (1976)
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H   Reversible and Irreversible Forms of Contractile Failure  Caused
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    Recent Adv. Stud. Card. Struct.  Metab.,  5:395-403 (1975)
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H   Therapy Refractory Myocardial  Insufficiencies  as  Possible
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    Pfluegers Arch. Eur. J. Physiol.,  332(Suppl.):R41 (1972)
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    Pfluegers Arch. Eur. J. Physiol.,  307(2):R23-4 (1969)
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    Mineralization of Bacteria by Fungi in Chloroform-fumigated
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    Soil Biol. & Biochem., 10(3):207 (1978)
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H   Formation of Cancerigenous Materials during Chlorination of
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H   Delayed Chloroform Poisoning in Obstetric Practice - A Clinical
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H   Effect of Narcotics and Muscle Relaxanta on the Secretion
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H   Action of Methanol-Chloroform on Liposomes of Adrenal Cortex
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    lela, L.; DiMeglio, M.;  Rastogi, R.K.
H   Effects of Anesthesia, Surgical Manipulation and Dehydration on
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H   Chloroform Toxicity in Mice;  Correlation of Renal and Hepatic
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    Illinois Institute for Environmental Quality.  Environmental
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H   Experimental Contribution to the Pharmacology of a
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    Ishitobi, K.
H   Experimental Studies on the Influence of Ethanol on the
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H   Effect of Inhalation Anesthetics on the  Conductance and Fusion
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    Ito, N.; Tatematsu, M.; Imaida, K.; et al.
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    Retaining the Viability of the Resting Egg of Brine-Shrimp
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    The Effects of Biocidal Treatments on Metabolism in Soil.   Part
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    The Effects of Biocidal Treatments on Metabolism in Soil.  V.  A
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E   The Effects of Biocidal Treatments on Metabolism in Soil.   III.
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    Jenks, R.L.; Klufo, C.; Astrup, T.
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Determination of Organic Compounds in Indoor Air with Potential
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E   The Reactions of Pygosteus pungitius L. to Toxic Solutions.
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    Formation of Chloroform during Chlorination of Drinking Water.
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    Water Supply Hygiene and Other Technical Study.
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    Malishevskava, A.S.; Kmasov, V.M.
H   Diagnosing Animal Poisoning by Toxic Chemicals.
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    Maloff, G.A.
H   Studies on the Toxicology of the Chlorine Derivatives of Methane
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    Maione, B.
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    Maione, B.
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    Maloney, A.H.; Graves, B.; Rhodes, L.C.
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    Malten, K.E.; Spruit, D.; Boemaars, H.G.; et al.
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    Maltsev, N.A.; Abetsedarskaya, L.A.
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    Mansuy, D.; Beaune, P.; Cresteil,  T.; et al.
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    Biochem. Biophys. Res. Conmun., 79(2):513-7 (1977)

    Marcarian, J.; Spirito, G.W.; Arregger, A.; et al.
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    Marker, A.; Paleg, L.G.; Spotswood,  T.M.
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    Mars, G.F.
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    Martin, B.R.; Marston, A.; Montgomery, J.; et al.
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    Martin, J.M.
H   Hepatic Necrosis due to Alloxan and Chloroform;  Aggravating and
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    Martin, J.M.
H   Production of Hepatic Necrosis by Alloxan and Chloroform.
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    Martinengo, L.
H   Chloroform Action on Liver.
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    Maruoka, S.
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    Marx, J.L.
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    Mas, L.C.
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    Masuda, Y.; Murano,  T.
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    Masuda, Y.; Yano, I.; Murano, T.
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H   The First Fatal Case of Chloroform Anaesthesia in Australia.
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    Matsumoto, Y.
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    Matsushita, J.
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    Matturro, F.
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    Matuda, K.
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    Matusige, T.; Goto, R.
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    Maugh, T.H.
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    Mayman, C.I.; Gatfield, P.D.; Breckenridge, B.M.
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    McAuliffe, C.D.
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    McBride, D.G.
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    McCarthy, G.
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    McCarty, P.L.; Reinhard, M.
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    McCarty, P.L.; Reinhard, M.; Argo, D.G.
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    McCay, P.B.; Noguchi, T.; Lai, E.K.; et al.
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    McGuire, M.J.
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    Dissertation for Ph.D. Drexel University
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H   Increased Susceptibility to Chloroform Poisoning Produced in the
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    McKinney, J.D.; Maurer, R.R.; Mass, J.R.; et al.
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    McLean, A.E.
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    McLean, A.E.M.
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    McLure, I.
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    McLure, I.
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    McMartin, D.N.; O'Connor, J.A.; Kaminsky, L.S.
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    McNally, W.D.
H   A Case of Phosgene Poisoning.
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    McReynolds, E.G.; Thorogood, A.; Morris, L.E.
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    Meek, W.J.
H   Effects of the General Anesthetics and Sympathomimetic Amines on
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    Meek, W.J.; Hathaway, H.R.; Orth, O.S.
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    J. Pharmacol. Exp. Ther., 61:240-52 (1937)

    Meersseman, F; Perrot, L.; Franque, E.
H   Research on Experimental Liver Insufficiency.  Mallard's
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    C. R. Soc. Biol., 117:934-6 (1934)

    Megirian, D.; Vasey, J.; Postemak, J.
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    Mehendale, H.M.; Davis, M.E.
H   Functional and Biochemical Correlates of Chlordecone Exposure
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    Meijers, A.P.; Rook, J.J.; Schultink, B.; et al.
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    Meirsman-Roobroeck, G.C.
H   The Protective Action of Parpanit, Diparcol, and Some Other
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    Melville, K.I.
H   Protective Action of Atebrin against Chloroform-Adrenaline
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    J. Pharmacol., 87:350-9 (1946)

    Melville, K.I.
H   Further Studies on the Antifibrillatory Action of Coronary
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    Meresz, 0.; Nicholson, A.A.
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    Conference:  1976 Pittsburgh Conference on Analytical Chemistry
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    Hereto, G.C.; Quarati, A.; Baldini, C.
H   Notes on the Acute Toxicity of Anaesthetics;   Evaluation and
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    Minerva Anestesiol., 45(3):97-101 (1979) (Ita)

    Merin, R.G.
H   Inhalation Anesthetics and Myocardial Metabolism;   Possible
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    Anesthesiology, 39:216-55 (1973)

    Merrin, A.
H   A Case of Delayed Chloroform Poisoning.
    Br. Med. J., 2:405 (Sep. 10, 1921)

    Meszaros, A.
H   Influence of Population Density (Social Stress) on Weight Gain
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    Wiener Tierarztl. Monatsschr., 67(2):63 (1980)

    Metzger, H.; Barthelme, P.; Urban, M.
H   Variations of Serum Phosphatase after Ingestion of Chloroform.
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    Meyer, F.
H   Percutaneous Absorption of Cardiac Glycosides.
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    Meyer, J.
H   Modification of Mitosis by Chemicals.
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    M'Gowan, J.P.
H   Chloroform Poisoning - Its Biological Significance.
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    Michael, L.C.; Erickson, M.D.; Parks, S.P.; et al.
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    Anal. Chem., 52(12):1836-41 (1980)

    Michenfelder, J.D.; Van Dyke, R.A.; Theye, R.A.
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    Anesthesiology, 33:315-21 (1970)

    Mieure, J.P.; Dietrich, M.W.
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H   Effect of Narcotics on Cholinesterase Activity.  Experiments In
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    Farmakol. Toksikol., 6(5):49-51 (1943)

    Mikhelson, V.A.; Zhdanov, 6.G.; Chernobelsky, A.M.
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    Khirurgiya (Moscow), 51(10):89-92 (1975) (Rus)

    Mikiskova, H.; Mikiska, A.
H   Some Electrophysiological Methods for Studying the Action of
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    Br. J. Ind. Med., 25(2):81-105 (1968)

    Mikkelsen, S.; Gregersen, P.; Klausen, H.;  et al.
H   Presenile Dementia As an Occupational Disease Following
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    Ugeskr. Laeg., 140(27):1633-8 (1978) (Dan)

    Miklashevskii, V.E.; Tugarinova, V.N.; Rakhmanina, N.L.;  et al.
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    Gig. Sanit., 31(8):107-8 (1966) (Rus)

    Millar, R.A.; Warden, J.C.; Cooperman, L.H.; et al.
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    Millar, W.M.; Park, J.
H   Morphine and Chloroform in Liver Atrophy.
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    Miller, E.G.; Miller, J.A.
H   Milestones in Chemical Carcinogenesis.
    Semin. Oncol., 6(4):445-60 (1979)

    Miller, J.C.; Kitz, R.J.
H   Effect of Anesthetics on the Metabolism of  Phosphatidyl Inositol
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    Fed. Proc., 33(3 Part 1):467 (1974)

    Miller, J.C.; Miller, K.W.
H   Approaches to the Mechanisms of Action of  General Anesthetics.
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H   Nutritional Factors Affecting the Toxicity of Halogenated
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    Occup. Med., 5:194-209 (Feb. 1948)

    Miller, L.L.; Whipple, G.H.
H   Liver Injury, Liver Protection, and Sulfur Metabolism.
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    J. Exp. Med., 76(5):421-35 (1942)

    Miller, L.L.; Whipple, G.H.
H   Chloroform Liver Injury Increases As Protein Stores Decrease.
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    Miller, R.A.; Warden, J.C.; Looperman, L.H.; et al.
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    Miller, R.L.; Micik, R.E.
E   Air Pollution and Its Control in the Dental Office.
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    Miller, R.W.
E   Carcinogens in Drinking Water.
    Pediatrics, 57(4):462-4 (1976)

    Minear, R.A.
E   Production, Fate, and Removal of Trihalomethanes in Municipal
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    Office of Water Research and Technology,  Report
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    Minor, A.V.; Byzov, A.L.
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    Minot, A.S.; Cutler, J.T.
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    Miquel, 0.
H   The Effect of Chloroform and Ether on the Activity of
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H   Effects of Various Substances on Adenosinetriphosphatase
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    Miroliubova, S.P.
H   Rapid Determination of Inhalation Anesthetics in the Blood by
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    Eksp. Khir. Anesteziol.,  15(2):87-9 (Mar.-Apr.  1970) (Rus)

    Mitchell, B.; Littlejohn, A.
H   The Effect of Anaesthesia and Posture  on the Exchange of
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    Mitchell, J.R.; McMurtry, R.J.; Statham, L.N.;  et al.
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    Mitre Corporation
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    Miyashita, K.; Robinson,  A.B.
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    Mech. Ageing Dev., 13(2):177-84 (1980)

    Miyazaki, M.
H   Fat Metabolism.  III. Experimental Studies on the
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    Mizoguchi, I.
E   Local Distribution of Chlorinated Hydrocarbons  in the Ambient
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    Atmos. Environ., 10(7):557-60 (1976)

    Molitor, H.; Kuna, S.
H   Influence of Inhalation Anesthetics on Liver.
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H   Catechol Amines of the Skin in Chloroform Inflammation.
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    Moore, G.S.; Tuthill, R.W.; Polakoff, D.W.
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    Moore, L.
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    Morita, M.; Nakamura, H.;  Mimura,  S.
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    Ogata, K.
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H   Absorption and Elimination of Inhalation Anesthetics  and  Inert
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H   Morphological Studies on the Hepatotoxic Effects of Various
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    Orth, O.S.; Stutzman, J.W.
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    Orth, O.S.; Liebenow,  R.R.;  Capps,  R.T.
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    Osaki, H.; Ogata, M.
E   Analysis by Roach's Theory on Accumulation  of Organic Chloride
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H   Liver Damage Caused by Hepatotoxic Poisons  and Serum
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    Paradise, R.R.; Bibbins, F.
H   Comparison of the Effects of Equieffective Concentrations  of
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    Petzold, G.L.; Swenberg, J.A.
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    Pohl, L.R.; Krishna, G.
H   Deuterium Isotope Effect in Bioactivation and Hepatotoxicity of
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    Life Sci., 23(10):1067-72 (1978)

    Pohl, L.R.; Bhooshan, B.; Krishna, G.
H   Phosgene;  A Potential Metabolite of Chloroform.
    Pharmacologist, 19(2): 192 (1977)
                                 199

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    Pohl, L.R.; Bhooshan, B.J Krishna, G.
H   Mechanism of the Metabolic Activation of Chloroform.
    Conference:  17th Annual Meeting of the Society of Toxicology.
    San Francisco, CA, 1978.
    Toxicol. Appl. Pharmacol., 45(1):238 (1978)

    Pohl, L.R.; Martin, J.A.; George J.W.
H   Mechanism of Metabolic Activation of Chloroform by Rat Liver
    Microsomes.
    Biochem. Pharmacol., 29(24):3271-6 (1980)

    Pohl, L.R.; Bhooshan, B.; Whittaker, N.F.;  et al.
H   Phosgene;  A Metabolite of Chloroform.
    Biochem. Biophys. Res. Commun., 79(3):684-91 (1977)

    Pohl, L.R.; George, J.W.; Martin, J.L.; et  al.
H   Deuterium Isotope Effect in In Vivo Bioactivation of  Chloroform
    to Phosgene.
    Biochem. Pharmacol., 28(4):561-3 (1979)

    Pohl, L.R.; George, J.W.; Martin, J.L.; et  al.
H   Phosgene;  An In Vivo Metabolite of Chloroform.
    Toxicol. Appl. Pharmacol., 48(1):A110 (1979)

    Pohl, L.R.; Martin, J.L.; George, J.W.; et  al.
H   A Mechanism for the Depletion of Liver Glutathione by Trihalo-
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    Pohl, L.R.; Martin, J.L.; Taburet, A.M.; et al.
H   Oxidative bioactivation of Haloforms into Hepatotoxins.
    Proceedings:  4th International Symposium on Microsomes and Drug
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    1979.  Edited by Estabrook, R.W.  New York:  Academic Press,
    2:881-4 (1980)

    Poitras, J.M.
H   Modern Use for Chloroform.
    Md. State Med. J., 28(l):54-5 (1979)

    Politzer, I.R.; McDonald, L.K.; Laseter, J.L.
H   Identification of Some Volatile Endogenous  Constituents in Rat
    Brain Tissue and the Effects of Lithium Carbonate  and Chloral
    Hydrate.
    Res. Commun. Chem. Pathol. Pharmacol., 15(3):469-81 (Nov.  1976)

    Pollard, B.J.; Millar, R.A.
H   Potentiating and Depressant Effects of Inhalation  Anaesthetics
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    Br. J. Anaesth., 45(5):404-15 (May 1973)
                                 200

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    Pollard, M.; Burleson, G.R.; Luckert, P.H.
H   Factors That Modify the Rate and Extent of Spontaneous
    Metastases of Prostate Tumors in Rats.
    Prog. Cancer Res. Ther., 5(Cancer Invasion Metastasis:  Biol.
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    Polonovski, M.; Lindenberg, B.A.
E   Narcosis and Toxicity in Fish.
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    Poobalasingham, N.
H   Analysis of Chloroform in Blood.
    Br. J. Anaesth., 48(10):953-6 (1976)

    Poobalasingham, N.; Payne, J.P.
H   Uptake and Distribution of Chloroform in Man.
    Br. J. Anaesth., 47(5):632 (1975)

    Poobalasingham, N.; Payne, J.P.
H   The Uptake and Elimination of Chloroform in Man.
    Br. J. Anaesth., 50(4):325-9 (Apr. 1978)

    Popli, T.S.; Paul, B.S.
H   Blood Levels of Chloroform during Anesthesia in Different
    Combinations in Bubalus bubalis.
    J. Res. Punjab Agric. Univ., 14(3):368-71 (1978)

    Popoff, M.; Dimitrov, A.
H   Mutations of Drosophila melanogaster Produced  by  Chemical Action.
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    Popova, N.N.
H   Study of the Effect of Physical and Chemical Agents on
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    Popper, H.E.; Rubin, D.
H   Drug-induced Liver Disease.
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    Porsius, A.J.; Van Zwieten, P.A.
H   Quantitative Evaluation of the Cardiodepressive Action of
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    Arch. Int. Pharmacodyn. Ther., 205(1):134-43 (Sep. 1973)

    Porsius, A.J.; Van Zwieten, P.A.
H   Anesthetic Agents and Glycolysis.  Lack of Influence of
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                                 201

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    Posgate, E.S.
E   Turbidimeters Curb Health Risks.
    Water Wastes Eng., 16(2):45-8 (Feb.  1979)

    Posternak, J.; Berney, J.
H   Effects of a Few Narcotics on the Excitability of the  Sciatic
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    Powers, M.B.
H   Evaluation of Oncogenic Potential of Chloroform by Chronic  Oral
    Administration in Rodents.
    Conference:  15th Annual Meeting  of  the Society of Toxicology.
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    Powers, M.B.; Voelker, R.W.
H   Evaluation of the Oncogenic Potential of Chloroform by Long-Term
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    Toxicol. Appl. Pharmacol., 37(1):179 (1976)

    Powlson, D.S.; Jenkinson, D.S.
E   The Effects of Biocidal Treatments on Metabolism in Soil.   I.
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    Soil Biol. Biochem.,  8(3):167-77  (1976)

    Powlson, D.S.; Jenkinson, D.S.
E   The Effects of Biocidal Treatments on Metabolism in Soil.   II.
    Gamma Irradiation, Autoclaving, Air-Drying,  and Fumigation.
    Soil Biol. Biochem.;  8(3):179-88  (1976)

    Pradhan, S.N.; Galambos, R.
H   Some Effects of Anesthetics on the Evoked Responses in the
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    Prasad, V.S.; Subramonia, I.K.
E   Organics in Drinking Water.
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    Praslicka, M.; Helona, J.; Havelka,  J.; et  al.
E   Effects of Simultaneous Action of X-ray and  Anesthetic or
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    Predtechenskii
H   The Influence of Inhalation Narcosis (Chloroform-Ether) on  the
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                                 202

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    Premel-Cabic, A.; Cailleux,  A.;  Allain,  P.
H   A Gas Chromatographic Assay of Fifteen Volatile Organic Solvents
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    Clin. Chim. Acta, 56(1):5-11 (Oct. 15, 1974)  (Fre)

    Preussmarm, R.
H   Chloroform in Drinking Water - Approaches  to  a Toxicological
    Evaluation.
    WaBoLu-Ber., (3):124-8 (1978) (Ger)

    Preussmann, R.
H   Hepatocarcinogens As Potential Risk for  Human Liver Cancer.
    Proceedings:  Falk Symposium, No.  25.  Primary Liver Tumors.
    Titisee, West Germany.  Oct. 3-5,  1977.   pp.  11-30  (Pub.  1978)

    Preussmann, R.
H   Toxicological Aspects of Food Safety —  Carcinogenicity and
    Mutagenicity.
    Arch. Toxicol., Suppl., (l):69-84  (1978)

    Price, H.L.; Cohen, P.J.
H   Effect of Anesthetics on the Circulation.   Springfield:  Thomas,
    1964

    Price, H.L.; Deutsch, S.; Davidson, I.A.;  et  al.
H   Can General Anesthetics Produce Splanchnic  Visceral Hypoxia by
    Reducing Regional Blood Flow?
    Anesthesiology, 27:24 (1966)

    Price, M.L.; Price, H.L.
H   Effects of General Anesthetics on  Contractile Responses of
    Rabbit Aortic Strips.
    Anesthesiology, 23:16-20 (1962)

    Priestly, B.C.; Plaa, G.L.
H   Hepatic Function after Acute or Subchronic  Nicotine
    Administration in Untreated Mice and Mice  Treated with
    Hepatotoxic Chemicals.
    Arch. Int. Pharmacodyn., 223:132-41 (1976)

    Prince, L.C.; Rowe, H.M.; Passananti,  G.T.
H   The Effect of Anesthesia upon Liver Enzymes.   Guanase and
    Ornithine Carbamyl Transferase Reflecting Cellular  Damage.
    Anesthesiology, 26:258-9 (1965)

    Prins, R.A.; Van Nevel, C.J.; Demeyer, D.I.
E   Pure Culture Studies of Inhibitors for Methanogenic Bacteria.
    Antonie van Leeuwenhoek J. Microbiol.  Serol., 38(3):281-7 (1972)
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    Frost, G.; Rigaud, M.;  Pelletier,  N.
H   Industrial Hepatic Poisons;  General  Review and Classification.
    Arch. Mai. Prof. Med. Trav. Secur. Soc.,  38(1-2):205-25 (1977)
    (Fre)

    Pruggmayer, D.; Arendt, G.
H   Volatile Organic Compounds in Our Air.
    DECHEMA-Monogr., 80(1639-69):713-25 (1976) (Ger)

    Puchkova, L.V.
E   Effect of Anesthetizing Substances on the Quality of
    Chemoreceptor Sensillae Boundary Surfaces in Culicidae and
    Diptera Mosquitoes.
    Dopov. Akad. Nauk Ukr.  RSR, Ser. B, 34(10):949-51 (1972) (Ukr)

    Puri, S.K.; Fuller, G.C.; Lali, H.
H   Effect of Chloroform Inhalation on Barbiturate Narcosis and
    Metabolism in Normal and Phenobarbital-pretreated Rats.
    Pharmacol. Res. Common., 3(3):247-54  (1971)

    Puskin, J.S.; Martin, T.
H   Effects of Anesthetics  on Divalent Cation Binding and Fluidity
    of Phosphatidylserine Vesicles.
    Mol. Pharmacol., 14(3):454-62 (1978)

    Quaghebeur, D.; De Wulf, E.
E   Volatile Halogenated Hydrocarbons  in Belgian Drinking Waters.
    Sci. Total Environ., 14(l):43-52 (1980)

    Quastel, D.M.; Hackett, J.T.; Okamoto, K.
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    Depolarization-Secretion Coupling.
    Can. J. Physiol. Pharmacol., 50(3):279-84 (1972)

    Quimby, B.D.; Delaney,  M.F.; Uden, P.C.;  et al.
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    Chromatography with a Microwave Plasma Emmission Detector.
    Anal. Chem., 51(7):875-80 (1979)

    Quinn, J.E.; Snoeyink,  V.L.
E   Removal of Total Organic Halogen by Granular Activated Carbon
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    J. Am. Water Works Assoc., 72(8):483  (Aug. 1980)

    Quinot, E.; Moncelon, B.; Millard, M.
H   Toxic Substances in the Air.  Determination Method for
    Calculation of Exposure Limit Value.
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                                 204

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    Quirno, N.; Lopez-Garcia, A.; Zelasco, J.F.
H   Hepatosia Following Anesthesia during Labor - Study of 5 Cases
    An. Inst. Invest. Fis. Pi. Pat. Humana, 5:75-88 (1943)

    Ramadan, M.A.; Ramadan, M.I.A.
H   Histochemical Studies on the Effect of Some Anesthetics on Rat
    Liver.
    Acta Histochem., 34(2):310-6 (1969)

    Ramanathan, P.S.; Srivastava, O.P.; Venkateswarlu,  Ch.; et al.
E   Study of Anaesthetic Vapour Concentrations in Operation Theatres
    by Gas Chromatography.
    Indian J. Med. Res., 67(4):656-61 (1978)

    Ramos, A.O.; Bastos, W.P.; Sakate, M.
H   Influence of Metoclopramide in Experimental Arrhythmias Induced
    by Barium or by Chloroform and Adrenaline.
    Med. Pharmacol. Exp. (Basel), 17(5):385-90 (1967)

    Ramsey, J.C.; Gehring, P.J.
H   Application of Pharmacokinetic Principles in Practice.
    Fed. Proc., 39(l):60-5 (1980)    :

    Randolf, W.F.
H   Chloroform As an Ingredient of Drugs for Animal Use.
    Fed. Regist., 4152482 (Nov. 30, 1976)

    Randt, C.; Collins, W.; et al.
H   Effects of Anesthetic Agents on the Spinal Cord of  the Cat.
    Am. J. Physiol., 196:340 (1959)

    Rang, H.P.
H   Stimulant Actions of Volatile Anaesthetics on Smooth  Muscle.
    Br. J. Pharmacol., 22:356-65 (Apr. 1964)

    Rapisarda, L.M.
H   Experimental Studies on Liver Damage due to Anesthetics and the
    Protective Action of Thiooctic Acid.
    Minerva Anestesiol., 23:162-9 (1957)

    Rapisarda, L.M.
H   Electrophoretic Research on Cerebrospinal Fluid (CSF) Proteins
    in Anesthesia.
    Riv. Patol. Clin., 13:1-15 (1958)

    Rascanu, V.; Kapri, M.; Popovici, G.
H   Action of Chloroform, Evipal, and Barbital on Activity and
    Excitability of Cortical Motor Centers.
    C. R. Soc. Biol., 130:1602-5 (1939)
                                 205

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    Rasmussen, R.A.
E   Status of Washington State University's Interhemispheric
    Halocarbon and Nitrous Oxide Measurements.
    Conference:  Int. Conf. Probl. Relat.  States.,  NASA-CR-154106.
    1976. pp. 96-8 (1977)

    Rasmussen, R.A.; Pierotti, D.; Harsch, D.E.
E   Identificaion of a Potential Source of Chloroform in Urban Air.
    Chemosphere, 6(11): 769 (1977)

    Rasmussen, R.A.; Harsch, D.E.; Sweany, P.H.;  et al.
E   Determination of Atmospheric Halocarbons by  a
    Temperature-programmed Gas Chromatographic Freezeout
    Concentration Method.
    J. Air Pollut. Control Assoc., 27(6):579-81  (1977)

    Ratnoff, O.D.; Ramos, M.E.G.
H   Impaired Generation of Plasminogen in the Chloroform Treated
    Euglobulin Fraction of Pre-Kallikrein Deficient Fletcher Trait
    Plasma.
    Clin. Res., 26(3):555A (1978)

    Ravdin, I.S.; Vars, H.M.; Goldschmidt, S.; et al.
H   Anesthesia and Liver Damage; Effect of Anesthesia on Blood
    Sugar, Liver Glycogen, and Liver Fat.
    J. Pharmacol. Exp. Ther., 64:111-29 (1938)

    Ravner, H.; Zisman, W.A.
H   A Survey of Possible Substitutes for Carbon  Tetrachloride As
    Nonflammable Solvents for Shipboard Use.
    Naval Research Laboratory, Washington, D.C.,  14 pp. (Sep. 1954)

    Ravnskov, U.
H   Exposure to Organic Solvents - A Missing Link in
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    Acta Med. Scand., 203(5):351-6 (1978)

    Rawlings, G.D.; DeAngelis, D.G.
E   Toxicity Removal in Textile Plant Waste Waters.
    J. Am. Leather Chem. Assoc., 74(11):404-17 (1979)

    Rechlin, R.
H   Acute Halogen Hydrocarbon Poisoning in Children.
    Dtsch. Gesundheitswes., 32(6):275-8 (1977) (Ger)

    Reddrop, C.J.; Riess, W.; Slater, T.F.
    Two Rapid Methods for the Simultaneous Gas-Liquid
    Chromatographic Determination of Carbon Tetrachloride and
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                                206

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    Reed, S.B.; Strobel, G.E. Jr.
H   An In Vitro Model of Malignant Hyperthermia;   Differential
    Effects of Inhalation Anesthetics on Caffeine-induced Muscle
    Contractures.
    Anesthesiology, 48(4):254-9 (1978)

    Rees, K.R.; Zuckerman, A.J.
H   Lack of Toxicity of Halothane on Differentiated Liver Cell
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    Br. J. Anaesth., 39(11):857-60 (Nov. 1967)

    Regli, S.; Vogt, C.
E   Controlling Trihalomethanes While Attaining Disinfection.
    J.Am. Waterworks Assoc., 73(1):33 (1981)

    Regnauld, J.; Villejean
H   Differentiating Characteristics of Chloroform and Methylene
    Chloride from the Physiological Point of View.
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    Rehn, E.; Killian, H.
H   Critical Survey of Anesthetic Procedures.  II. General
    Anesthesia (Conclusion).
    Munch. Med. Wochenschr., 42:1665-70 (1932) (Ger)

    Reichard, H.; Wiavist, N.; Yllner, S.
H   Chloroform Anesthesia in Obstetrics.  Its Effect on the Serum
    Activity of Omithine Carbamyl Transferase, Glutamic Oxalacetic
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    Reid, D.S.; Measures, J.
E   Microbiological Effects of Clathrate Formers.
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    Reid, W.D.; Ilett, K.F.
H   Mechanism of Renal Necrosis Induced by Chlorobenzene or
    Chloroform.
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    Reiner, 0.; Athanassopoulos, S.; Hellmer, K.H.; et al.
H   Formation of Chloroform from Carbon Tetrachloride in Liver
    Microsomes, Lipid Peroxidation, and Destruction of Cytochrome
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    Arch. Toxikol., 29(3):219-33 (1972) (Ger)

    Re ith, J. F.
H   Carcinogens in Pharmacy and the Analytical Chemistry Laboratory.
    Pharm. Weekbl., 107( 37):581-97 (1973) (Dut)
                                 207

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    Reith, J.F.; Van Ditmarsch,  W.C.;  DeRuiter,  T.
E   Improved Procedure for Application of the Fujiwara Reaction in
    the Determination of Organic Halides.
    Analyst (London), 99(1183):652-6 (1974)

    Reitz, R.H.; Gehring, P.J.;  Park,  C.N.
H   Carcinogenic Risk Estimation for Chloroform;  An Alternative to
    Environmental Protection Agency's  Procedures.
    Food Cosmet. Toxicol., 16(5):511-4 (1978)

    Reitz, R.H.; Gehring, P.J.;  Watanabe, P.G.;  et  al.
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    Toxicol. Appl. Pharmacol., 48(1):A148 (1979)

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H   Pharmacokinetics and Macromolecular Effects  of  Chloroform in
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    Renne, R.F.
H   Pathology of Long Term Oral  Administration of Chloroform in
    Rodents.
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H   Pathology of Long-Term Oral  Administration of Chloroform in
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H   Carcinogenicity of Chloroform.
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    Reus, N.; Rueffer, H.
E   Waste Water from a Chemical-Pharmaceutical Works.
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    Wastewaters in Large Plants.  Vienna, Austria,  Sep. 3-7, 1979.
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H   The Functional State of the  Nerve  Centers of the Spinal Cord in
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    Reva, O.D.
H   Impairment of Spinal Cord-Reflex Responses in Narcosis.
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    Reyes, J. ; Latorre, R.
H   Effect of the Anesthetics Benzyl Alcohol and Chloroform on
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    Reyes, J. ; Latorre, R.
H   Effect of Neutral Anesthetics on Bilayers Made from Monolayers.
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H   Cardiac Output As Influenced by Ephedrin, Homocamfin,  Quinidine,
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    Reynolds, E.S.
H   Comparison of Early Injury to Liver Endoplasmic Reticulum by
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    Ethionine, Thioacetamide, and Dimethylnitrosamine.
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    Reynolds, E.S.
H   Liver Endoplasmic Reticulum;  Target Site of Halocarbon
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    Reynolds, E.S.; Yee, A.G.
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    Lab. Invest., 16(4) : 591-603  (Apr. 1967)

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                                 209

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E   Water-Disinfection Challengers Now on Tap.
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H   Electrophysiological Study of Some Symptoms of Cerebral
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E   Update;  What's in the Water.
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H   A Study of Liver Function in Dogs after Anesthesia with
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    Curr. Res. Anesth. Analg., 34:307 (1955)

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H   Plasma Concentrations of Epinephrine and Norepinephrine during
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H   The Action of General Anaesthetic Agents on Root Responses  of
    the Frog Isolated Spinal Cord.
    Br. J. Pharmacol. 36(2) :294-311 (1969)

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H   Effect of Volatile Anaesthetics on Mitochondrial Proteins.
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H   The Biotransformation of Inhalation Anesthetics and  Its
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                                 210

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H   General Anesthesia and Gastric Function.
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H   Toxicological and Safety Aspects of Chorinated Hydrocarbons.
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    (Ger)

    Rinzema, L.C.; Silverstein, L.G.
H   Hazards from Chlorinated Hydrocarbon Decomposition during
    Welding.
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    Schwetz, B.A.
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    Senderikhina, D.P.
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    Shen, T.C.R.; Simon, M.A.
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    Sherwood, R.J.
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    Smith, A.R.
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    Smith, H.
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    Smith, H.P.; Warner, E.D.; Brinkhous, K.M.
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    Smith, J.H.; Bomberger, D.C.
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    Smith, R.J.
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    Smith, V.L.; Cech, I.; Brown, J.H.; et al.
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    Smith, W.D.A.
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    Soucek, B.
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    Soucek, B; Vlachova, D.
H   Chloroform As a Metabolite of Trichloroethylene.
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    Souza, J.A.; Barreto, H.E.; Martins, E.O.
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    Spangberg, L.; Engstrom, B.
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    Spangberg, L.; Engstrom, B.
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    Speden, R.N.
H   The Effect of Some Volatile Anesthetics on the Transmurally
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    Br. J. Pharmacol., 25(1):104-18 (1965)

    Speicher, H.W.
H   Solvents;  Their Dangers and How to Control Them.
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    Spence, A.A.; Linton, A.L.; Patel,  A.R.
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    Spence, J.W.; Hanst, P.L.
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    Spence, J.W.; Hanst, P.L.; Gay, B.W.
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    Spiegel, E.A.; Spiegel-Adolf, M.
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    Stacey, N.H.; Priestly, B.C.; Hall, R.C.
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    Stander, H.J.
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    Stanojevic, L.; Petkovic, S.
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    Starkov, P.M.; Kochergin, E.F.
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    Stazhadze, L.L.; Zhilis, B.G.
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    Steele, R.H.; Wilhelm, D.L.
H   The Inflammatory Reaction in Chemical Injury.  I.  Increased
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    Steele, R.H.; Wilhelm, D.L.
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    Steensholt, G.; Venndt, H.
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    Stefan, M.
H   Effect of Chloroform Inhalation on Tyrosine Aminotransferase
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    Stefan, M.
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    Stefan, M.; Vladescu, C.
H   Stress-induced Response of Liver Tyrosine Aminotransferase  after
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    Stefan, M.; Boerescu, J.; Gheorghe, N.
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    Stefan, M.; Gheorghe, M.; Boerescu, J.
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    Stein, E.; Galyean, M.L.
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    Steinegger, E.; Levan, A.
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    Stevens, A.A.; Symons, J.M.
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    Stevens, A.A.; Slocum, C.J.; Seeger,  D.R.;  et al.
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    Stevens, J.L.; Anders, M.W.
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    Stevens, J.L.; Anders, M.W.
H   Covalent Binding of Chloroform Metabolites  to Metallothionein.
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    Stewart, H.B.
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    Stewart, K.M.
E   Tribalomethane Study of the Durham, New Hampshire  Water
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    Stieglitz, L.; Roth, W.
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    Stochaj, M.; Marcinkowski, T.
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    Stokinger, H.E.
H   Toxicology and Drinking Water Contaminants.
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    Stotzka, W.
E   Reduced Pressure Head3pace Analysis (RPHA) for the Determination
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    Sturrock, J.E.
H   Lack of Mutagenic Effect of Halothane or Chloroform on  Cultured
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    Br. J. Anaesth., 49(3):207-10 (1977)

    Sturrock, J.E.; Nunn, J.F.
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    Sumegi, I.
H   Fibrinoid Necrosis of Liver Parenchymal Cells.
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H   Report on Environmental Health Hazards at the Atlanta Pesticide
    Pollution Laboratory, Atlanta, Georgia.
    NIOSH Report No. TR-12:13 pp. (Nov. 1963)

    United States.  Department of Health,  Education,  and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and  Health
    Xintaros, C.; Johnson, B.L.; DeGroot,  I.
H   Behavioral Toxicology.
    U.S. DHEW (NIOSH) Publ. No. 74-126 (1974)
    United States.  Department of Health,  Education,  and Welfare.
    Public Health Service.  Center for Disease Control.   National
    Institute for Occupational Safety and  Health
H   Criteria Document;  Recommendations for an Occupational Exposure
    Standard to Chloroform.
    DHEW Publ. 75-114, 120 pp. (1974)

    United States.  Department of Health,  Education,  and Welfare.
    Public Health Service.  Center for Disease Control.   National
    Institute for Occupational Safety and  Health
    Scott Research Labs, Inc.
    Reckner, L.R.; Sachden, J.
E   Collaborative Testing of Activated Charcoal Sampling Tubes  for
    Seven Organic Solvents.
    Technical Information Report No. NIOSH-75/184
    U.S. NTIS, PB-267538, 229 pp. (1975)
                                 259

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    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and Health
    Revised Recommended Chloroform Standard.
    U.S. DHEW (1975)

    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and Health
    Current Intelligence Bulletin 9-Chlproform.
    NIOSH, Rockville, MD(Mar. 15, 1976)

    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and Health
    Chrostek, W.J.
H   Health Hazard Evaluation Report No. 76-9-345, W.R. Case and Sons
    Cutlery Company.
    Hazard Evaluation Services Branch, NIOSH-Cincinnati, OH  :13 pp.
    (Nov. 1976)

    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and Health
    Stanford Research Institute
E   NIOSH Analysis Methods for Set J.
    U.S. NTIS, PB-263959, 128 pp. (Dec. 1976)
    United States.  Department of Health, Education and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and Health
H   Criteria for a Recommended Standard.  Occupational Exposure to
    Waste Anesthetic Gases and Vapors.
    U.S. NTIS, PB-274238, 204 pp. (1977)

    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and Health
    White, G.L.
H   Hazard Evaluation and Technical Assistance Report No. TA-77-34,
    New York State Police Scientific Laboratories.
    U.S. NTIS, PB-278837, 17 pp. (Aug.  1977)
                                 260

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    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and Health
    Pryor, P.
H   Health Hazard Evaluation Determination Report No. 77-84-450,
    McCourt Label Company, Bradford, Pennsylvania.
    Hazard Evaluation Service Branch, NIOSH-Cincinnati, OH:13 pp.
    (Dec. 1977)

    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and Health
    Hervin, R.L.
H   Health Hazard Evaluation and Technical Assistance Report No. TA
    77-33, St. Luke's Hospital of Kansas City, Kansas City, Missouri.
    U.S. NTIS, PB-278795, 22 pp. (1977)

    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and Health
    Gunter, B.J.
H   Health Hazard Evaluation/Toxicity Determination Report
    76-101-376, FMC Corporation, Broomfield, CO.
    U.S. NTIS, PB-270858, 17 pp. (1977)

    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and Health
    Ludwig, H.R.
H   Industrial Hygiene Study of Suburban Dry Cleaners.
    NIOSH Division of Surveillance, Hazard Evaluations, and Field
    Studies; Industrial Hygiene Section Report:  10 pp. (Jun. 2,
    1977)

    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Center for Disease Control.  National
    Institute for Occupational Safety and Health
    NIOSH Revised Recommended Chloroform Standard.
    NIOSH, Cincinnati, OH, 5pp. (1977)
    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Food and Drug Administration
    Healton, D.C.
H   Infrared Analysis of Chlorinated Hydrocarbons in Drugs.
    J. Assoc. Offic. Agr. Chemists, 45(3):616-20 (1962)

    United States.  Department of Health, Education, and Welfare.
    Public Health Service.  Food and Drug Administration
    Healton, D.C.
H   Collaborative Study of an Infrared-Spectophotometric Assay for
    Some Chlorinated Hydrocarbons in Drugs.
    J. Assoc. Offic. Agr. Chemists, 46(4):652-4 (1963)

                                 261

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    United States.  Department of Health,  Education,  and Welfare.
    Public Health Service.  Food and Drug  Administration
H   Chloroform As an Ingredient of Drugs for Animal Use.
    Fed. Reg., 41(231):52482-4 (1976)
    United States.  Department of Health,  Education,  and Welfare.
    Public Health Service.  Food and Drug  Administration
    Chloroform As an Ingredient of Human Drug and Cosmetic  Products
    Proposed Revision of Labelling Requirements.
    Fed. Reg., 41(70):15026-9 (Apr. 9,  1976)
    United States.  Department of Health,  Education,  and Welfare.
    Public Health Service.  Food and Drug  Administration
H   Chloroform As an Ingredient of Human Drug and Cosmetic Products.
    Fed. Reg., 41(126):26842-6 (Jun. 29, 1976)

    United States.  Department of Health,  Education,  and Welfare.
    Public Health Service.  Food and Drug  Administration
    SRI International
    Simmon, V.F.
H   Structural Correlations of Carcinogenic and Mutagenic Alkyl
    Halides.
    Proceedings:  2nd Food and Drug Administration, Office of
    Science, Summer Symposium.  Structural Correlates of
    Carcinogenesis and Mutagenesis.  A Guide to Testing Priorities?
    Annapolis, MD, Aug. 31-Sep. 2, 1977.
    DHEW (FDA) Publ. No. 78-1046, 241 pp.  (1978)

    United States.  Department of Health,  Education,  and Welfare.
    Public Health Service.  Food and Drug  Administration
    Glower, M. Jr.
H   Modification of the AOAC Association of Official  Analytical
    Chemists' Method for Determination of  Fumigants  in Wheat.
    J. Assoc. Off. Anal. Chem., 63(3):539-45 (1980)

    United States.  Department of Health,  Education,  and Welfare.
    Public Health Service.  Institutes of  Health
    Von Oettinger, W.F.; Powell, C.C.; Sharpless, N.E.; et al.
H   Relation between the Toxic Action of Chlorinated  Methanes and
    Their Chemical and Physiochemical Properties.
    U.S. DHEW (NIH) Bulletin No. 191, 85 pp. (1949)

    United States.  Department of Health,  Educaton and Welfare.
    Public Health Service.  National Institutes of Health.  National
    Cancer Institute
H   Chloroform Causes Cancer in Laboratory Animals.
    National Cancer Institute Study Reports, Toxic Materials News,
    3:36 (1976)
                                 262

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    United States.  Department of Health,  Education,  and Welfare.
    Public Health Service.  National Institutes of Health.   National
    Cancer Institute
    Page, N.P.; Saffiotti, U.
H   Report on Carcinogenesis Bioassay of Chloroform.
    DHEW (NIH/NCI) Publ. No. 76-1279
    U.S. NTIS, PB-264018, 61 pp. (Mar. 1,  1976)
    United States.  Department of Health,  Education and  Welfare.
    Public Health Service.  National Institutes of Health.   National
    Cancer Institute.  Division of Cancer  Cause and Prevention
H   Report on Carcinogenesis Bioassay of Chloroform.
    Vet. Toxicol., 18(3):160-2 (1976)
    United States. Department of Health,  Education and Welfare.
    Public Health Service.  National Institutes  of Health.   National
    Cancer Institute
H   Carcinogenicity of Chloroform.
    Environ. Health Perspect., 31:171-82  (1979)

    United States.  Department of the Interior.   Bureau of  Mines
    Jones, G.W.
H   Explosion and Fire Hazards of Combustible Anesthetics.
    U.S. DOI, Bur. Mines Report Investigations,  3443:17 pp. (1939)

    United States.  Department of the Interior.   Bureau of  Mines
    Coward, H.F.; Jones, G.W.
H   Limits of Flammability of Gases and Vapors.
    U.S. DOI, Bur. Mines Bulletin,  503:368 pp. (1952)

    United States.  Department of Labor
    Hamilton, A.
H   The Making of Artificial Silk in the  United  States and  Some of
    the Dangers Attending It.
    U.S. DOL, Bulletin No. 10:151-60 C1937)

    United States.  Department of State.   Agency for International
    Development
    Miller, A.P.
H   Water and Man's Health.
    U.S. NTIS, PB80-122203, 118 pp. (Apr. 1962)  (Spa)

    United States.  Environmental Protection Agency
H   Human Exposure to Atmospheric Concentrations of Selected
    Chemicals.  Volume II.
    Office of Air Quality and Planning Standards EPA Report, 456  pp.
                                 263

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    United States.  Environmental Protection Agency
    Bellar, T.A.; Lichtenberg, J.J.; Kroner, R.C.
E   The Occurrence of Organohalides in Chlorinated Drinking Waters.
    Office of Water Research and Technology, EPA Report No.
    670/4-74-008
    U.S. NTIS, PB-238589, 13 pp. (1974)

    United States.  Environmental Protection Agency
    Bentley, R.E.; Heitmuller, T.; Sleight,  B.H. 3rd;  et al.
E   Acute Toxicity of Chloroform to Bluegill (Lepomis  macrochirus),
    Rainbow Trout (Salmo gairdneri), and Pink Shrimp (Penaeus
    duorarum).
    Criteria Branch.  Order No. WA-6-99-1414-B (1975)
    United States.  Environmental Protection Agency
E   Development Document for Interim Final Effluent Limitations.
    Guidelines and New Source Performance Standards for the
    Significant Organic Products Segment of the Organic Chemical
    Manufacturing Point Source Category.
    EPA 440/1-75/045, 388 pp. (1975)

    United States.  Environmental Protection Agency
    Morris, J.C.
E   Formation of Halogenated Organics by Chlorination of Water
    Supplies.
    EPA Report No. 600/1-75-002
    U.S. NTIS, PB-241511, 54 pp. (Mar. 1975)
    United States.  Environmental Protection Agency.
H   Preliminary Assessment of Suspected Carcinogens  in Drinking
    Water;  Report to Congress.
    Office of Toxic Substances.   U.S.  NTIS,  PB-250961,  115  pp.  (Dec.
    1975)

    United States.  Environmental Protection Agency
H   A Report Assessment of Health Risk from Organics  Drinking Water
    by an Ad Hoc Study Group to  the Hazardous Materials Advisory
    Committee.
    Science Advisory Board.  59  pp. (Apr.  30, 1975)
    United States.  Environmental Protection Agency
E   Report on the Problem of Halogenated Air Pollutants  and
    Stratospheric Ozone.
    EPA Report No. 600/9-75-008,  Research Triangle Park, N.C.,
    55 pp. (1975)
                                264

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    United States.  Environmental Protection Agency
    Symons, J.M.
    Interim Treatment Guide for the Control of Chloroform and Other
    Trihalomethanes.
    U.S. EPA Report, Office of Research and Development, 240 pp.
    (Jun. 1976)

    United States.  Environmental Protection Agency
    Potrepka, R.F.
    Risk of Chloroform.
    Office of Pesticides.  Criteria Evaluation Division.  (1976)
    United States.  Environmental Protection Agency
H   Summary Characterizations of Selected Chemicals of Near Term
    Interest.
    U.S. EPA Office of Toxic Substances Report PB-292419,  31 pp.
    U.S. NTIS, (Sep. 1976)

    United States.  Environmental Protection Agency
    Clark, R.M.; Guttman, D.L.; Crawford, J.L.; et al.
E   The Cost of Removing Chloroform and Other Trihalomethanes from
    Drinking Water Supplies.
    Office of Research and Development, EPA Report No. 600/1-77/008.
    U.S. NTIS, PB-264283, 114 pp. (Mar. 1977)

    United States.  Environmental Protection Agency
    Harms, L.L.; Looyenga, R.W.
E   Formation and Removal of Halogenated Hydrocarbons in Drinking
    Water;  A Case Study at Huron, South Dakota.
    EPA Report No. 908/3-77-001
    U.S. NTIS, PB80-159718, 57 pp. (Jan. 1977)

    United States.  Environmental Protection Agency
    Pitts, J.N. Jr.; Winer, A.M.; Darnall, K.R.;  et al.
    Hydrocarbon Reactivity and the Role of Hydrocarbons, Oxides  of
    Nitrogen, and Aged Smog in the Production of Photochemical
    Oxidants.
    Office of Research and Development, EPA Report No. 600/3-77-0016
    U.S. NTIS, PB-264233, pp. 687-704 (1977)

    United States.  Environmental Protection Agency
    Radding, S.B.; Liu, D.H.; Johnson,  H.L.; et al.
E   Review of the Environmental Fate of Selected  Chemicals.
    Office of Toxic Substances.EPA Report No. 560/5-77-003 (May
    1977)
                                 265

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    United States.  Environmental Protection Agency
    Crane, A.M.; Freeman, A.E.
H   Water-softening and Conditioning Equipment;   A Potential  Source
    of Water Contamination.
    EPA Report No. 600/3-77-107
    U.S. NTIS, PB-274083, 19 pp. (Aug. 1977)

    United States.  Environmental Protection Agency
    Crane, A.M.; Freeman, A.E.
H   Water-softening and Conditioning Equipment;   A Potential  Source
    of Water Contamination.
    U.S. EPA Report,  pp. 3-8 (Sep.  1977)
    United States.  Environmental Protection Agency
E   Ambient Water Quality Criteria;   Chloroform.
    U.S. NTIS, PB-292427, 73 pp. (1978)

    United States.  Environmental Protection Agency
    Westrick, J.J.; Cummins, M.D.; Cohen,  J.M.
E   Breakpoint Chlorination/Activated Carbon Treatment;   Effect  of
    Volatile Halogenated Organics.
    Office of Research and Development,  EPA Report No.  600/2-78-165
    U.S. NTIS, PB-287129, 88 pp. (1978)

    United States.  Environmental Protection Agency
E   Interim Primary Drinking Water Regulations;   Control  of Organic
    Chemical Contaminants in Drinking Water.
    Fed. Regist., 43(28):5756-80 (Feb. 9,  1978)

    United States.  Environmental Protection Agency
    Pellizzari, E.D.
E   Quantification of Chlorinated Hydrocarbons  in Previously
    Collected Air Samples.
    Office of Air Quality and Planning Standards,  EPA Report No.
    450/3-78/112
    U.S. NTIS, PB-289804, 151 pp. (1978)

    United States.  Environmental Protection Agency
    Westrick, J.J.
E   Removal of Volatile Halogenated Organics Compounds  by Activated
    Carbon.
    Conference:  6th Symposium on Advanced Equipment  Facilitating
    Wastewater Treatment.
    U.S. NTIS, PB-290996, pp. 10-7 (1978)

    United States.  Environmental Protection Agency
    Easty, D.B.; Borchardt, L.G.; Waters,  B.A.
E   Removal of Wood-Derived Toxins from Pulping  and Wastes.
    EPA Technical Report No. 600/2-78-031
    U.S. NTIS, PB-277185, 85 pp. (Feb. 1978)
                                266

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    United States.  Environmental Protection Agency
E   Statement of Basis and Purpose for an Amendment to  the  National
    Interim Primary Drinking Water Regulations  on Tribalomethanes.
    Office of Water Supply.  Criteria and Standards Division,   pp.
    3,5,6,11-5 (Jan. 1978)

    United States.  Environmental Protection Agency
    Snelson, A.; Butler, R.; Jarke, E.
    Study of Removal Processes for Halogenated  Air Pollutants.
    Office of Research and Development, EPA Report No.  600/3-78-058
    U.S. NTIS, PB-284056, 118 pp. (1978)

    United States.  Environmental Protection Agency
    Newell, G.W.; Dilley, J.V.
H   Teratology and Acute Toxicology of Selected Chemical  Pesticides
    Administered by Inhalation.
    Office of Research and Development, Health  Effects  Research
    Laboratory.  EPA Report No. 600/1-78-003 (Jan. 1978)

    United States.  Environmental Protection Agency
    Severn, D.J.
H   Assessment of Human Exposure and Body Burdens of Chlorinated
    Byproducts.
    Conference:  3rd Conference on Water Chlorination.  Colorado
    Springs, CO, Oct. 28-Nov. 2, 1979.
    Office of Pesticide Prog. Health Evaluation Division

    United States.  Environmental Protection Agency
    Linde, H.W.; Mesnick, P.S.
H   Causes of Death of Anesthesiologists from the Chloroform Era.
    Jan. 1, 1930 - Dec. 31, 1946, Final Report.
    Health Effects Research Laboratory.  Office of Research and
    Development, EPA Report No. 600/1-79-043
    U.S. NTIS, PB80-125172, 30 pp. (Oct. 1979)

    United States.  Environmental Protection Agency
    Randolph, K.B.; Kay, L.B.; Smith, R.C. Jr.
E   Characterization of Preparation Plant Wastewaters.
    Proceedings:  Symposium on Coal Cleaning to Achieve Energy  and
    Environmental Goals, Vol. 2, 1978.
    Office of Research and Development.  EPA Report No. 600/7-70/098b
    U.S. NTIS, PB-299384, pp. 824-55 (1979)

    United States.  Environmental Protection Agency
    Tracer Jitco, Inc.
    Huffman, R.D.; Latanich, C.M.; Collins, T.K.; et al.
H   Metabolism Summaries of Selected Halogenated Organic  Compounds
    in Human and Environmental Media;  A Literature Study.
    EPA Report No. 560/6-79-008, pp. 18-22, 124-5, 204-6  (Apr.  1979)
                                 267

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    United States.  Environmental Protection Agency
    Organic Solvent Cleaners - Background Information for Proposed
    Standards.
    Office of Air Quality Planning and Standards.   EPA Report No.
    450/2-78-045a
    U.S. NTIS., 282 pp. (Oct. 1979)

    United States.  Environmental Protection Agency
    Birge, W.J.; Black, J.A.; Bruser,  D.M.
E   Toxicity of Organic Chemicals to Embryo-Larval  Stages of Fish.
    Office of Toxic Substances.  EPA Report No.  560/11-79-007  (Jun.
    1979)

    United States.  Environmental Protection Agency
    Rawlings, G.D.; Samfield, M.
H   Toxicity of Secondary Effluents from Textile Plants.
    Proceedings:  Symposium Process Meas. Environ.  Assess.  1978
    Office of Research and Development, EPA Report  No. 600/7-78-168
    U.S. NTIS, PB-290331,  pp. 153-69 (1979)


    United States.  Environmental Protection Agency
E   Water Quality Criteria.  Request for Comments.
    Fed. Reg., 44(52):1592-681 (Mar. 15, 1979)
    United States.  Environmental Protection Agency
    Ambient Water Quality Criteria for Chloroform.
    Office of Water Regulations and Standards.   EPA Report  No.
    440/5-80-033, 70 pp.  (Oct.  1980)

    United States.  Environmental Protection Agency
    Battelle Columbus Labs
    Analytical Procedures for Determining Organic Priority
    Pollutants in Municipal Sludges.
    Office of Research and Development, EPA Report  No.
    600/2-80-030:55 pp. (1980)

    United States. Environmental Protection Agency
    Crane, A.M.; Erickson, S.J.; Hawkins, C.E.
    Contribution of Marine Algae to Trihalomethane  Production in
    Chlorinated Estuarine Water.
    U.S. EPA Report No. 600/J-80-215,  13 pp. (Nov.  19,  1979)
    Estuarine Coastal Mar. Sci., 2:239-49 (1980)

    United States.  Environmental Protection Agency
    Development Document  for Effluent  Limitations.   Guidelines  and
    Standards for the Pulp, Paper and  Paperboard, and  the Builders
    Paper and Board Mills.
    Effluent Guidelines Division.  EPA Report No. 440/1-80/025-b
    (Nov.-Dec. 1980)
                                268

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    United States.  Environmental Protection Agency
    Jorgenson, T.A.; Rushbrook, C.J.
H   Effects of Chloroform in the Drinking Water of Rats  and Mice;
    Ninety-Day Subacute Toxicity Study.
    Office of Research and Development.   EPA Report No.  600/1-80-030
    U.S. NTIS, PB80-219108, 36 pp. (Jul.  1980)

    United States.  Environmental Protection Agency
    JRB Associates, Inc.
    Final Report.  Level I Materials  Balance.  Chloroform.
    Office of Pesticides and Toxic Substances.   Exposure Evaluation
    Division, EPA Report No. 560/13-80-007.   (Feb. 1980)

    United States.  Environmental Protection Agency
    Morris, J.C.; Ram, N.; Baum, B.;  et  al.
E   Formation and Significance of n-Chloro Compounds in  Water
    Supplies.
    EPA Report No. 60012-80-031
    U.S. NTIS, PB80-219298, 362 pp.  (Jul. 1980)

    United States.  Environmental Protection Agency
    Glaze, W.H.; Peyton, G.R.; Huang, F.Y.;  et  al.
E   Oxidation of Water Supply Refractory Species by Ozone with
    Ultraviolet Radiation.
    EPA Report No. 600/2-80-110
    U.S. NTIS, PB81-107104, 323 pp.  (Aug. 1980)

    United States.  Environmental Protection Agency
    Wood, P.R.; Jackson, D.F.; Gerves, J.A.; et al.
E   Removing Potential Organic Carcinogens and  Precursors from
    Drinking Water.  Vol. 1 and Appendix A.
    EPA Report No. 600/2-80-130A
    U.S. NTIS, PB81-107146, 391 pp.  (Aug. 1980)

    United States.  Environmental Protection Agency
    McCarty, P.L.; Reinhard, M.; Graydon, J.; et al.
E   Wastewater Contaminate.  Removal  for Groundwater Recharge at
    Water Factory 21.
    EPA Report No. 600/2-80-114
    U.S. NTIS, PB81-107088, 165 pp.  (Aug. 1980)

    United States.  Environmental Protection Agency
E   Water Treatment Process Modifications for Trihalomethane Control
    and Organic Substances in the Ohio River.
    Office of Research and Development,  Final Report
    EPA Report No. 600/2-80-028:307  pp.  (1980)
                                 269

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    United States.  Executive Office of the President.  Council  on
    Environmental Quality
    Crump, K.S.; Guess, H.A.
H   Drinking Water and Cancer;  Review of Recent Findings and
    Assessment of Risks.
    Superintendent of Documents.  Washington,  DC: Government
    Printing Office (Dec. 1980)

    United States.  Executive Office of the President.   Council on
    Environmental Quality
E   Contamination of Ground Water by Toxic Organic Chemicals.
    Superintendent of Documents.  Washington,  D.C.:  Government
    Printing Office (Jan. 1981)

    United States.  National Academy of Sciences
E   Direct Ecosystem Exposure and Effects.
    In:  Principles for Evaluating Chemicals in the Environment.
    NAS Publication:  pp. 154-204

    United States.  National Academy of Sciences
H   Epidemiological Studies of Cancer Frequency and Certain Organic
    Constituents of Drinking Water;  A Review of Recent Literature
    for the United States Environmental Protection Agency.
    U.S. NAS.  Washington, DC

    United States.  National Academy of Sciences.  National Research
    Counc il
E   Chloroform, Carbon Tetrachloride, and Other Halomethanes;   An
    Environmental Assessment.
    NAS Report Prepared by the Panel on Low Molecular Weight
    Halogenated Hydrocarbons, NRC:294 pp. (1978)

    United States.  National Academy of Sciences
E   Nonfluorinated Halomethanes in the Environment.
    National Research Council, Environmental Studies Board  (1978)

    United States.  National Academy of Sciences
H   Toxicity of Selected Drinking Water Contaminants.
    In:  Drinking Water and Health.  Vol. 3.  Washington, DC:XOLLNAS
    Publ. pp. 67-70, 1980

    United States.  National Aeronautics and Space Administration
    Hodgkiss, W.S.; Johns, R.H.; Swinehart, J.S.
    Environmental Testing of Contaminant-Producing Materials from
    the Integrated Life Support System (ILSS).
    NASA Report (CR-794):100 pp. (1967)
                                270

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    United States.  National Science Foundation
    SRI International
    Brown, S.L.; Chan, F.Y.; Jones, J.L.; et al.
H   Research Program on Hazard Priority Ranking of Manufactured
    Chemicals(Chemicals 41-60).
    U.S. NTIS, PB-263163, 191 pp. (1975)

    United States.  Nuclear Regulatory Commission
    Battelle Pacific Northwest Labs
    Anderson, D.R.; Lust, E.B.
E   Acute Toxicity and Bioaccumulation of Chloroform to Four Species
    of Fresh Water Fish:  Salmo gairdneri (Rainbow Trout),  Lepomis
    macrochirus (Bluegill), Micropterus salmoides(Largemouth Bass).
    Report No. PNL-3046, 46 pp. (Aug. 1980)
    United States.  Nuclear Regulatory Commision Battelle Pacific
    Northwest Labs
    Anderson, D.R.; Bean, R.M.; Schinner,  R.E.
    Chronic Effects of Chlorination By-Products on Salmo gairderi
    (Rainbow Trout).
    NRC Report No. PNL-3045, 37 pp. (Nov.  1980)
    Urban, H.; Erdmann, W.D.
H   Comparative Study on Fatty Degeneration of the Liver Following
    Chloroform and Halothane Anesthesia in Rats.   Effect of Oxygen
    Inhalation under Alternating Pressure.
    Anaesthesist, 14:79-82 (Mar. 1965) (Ger)
    Urich, R.W.; Bowerman, D.L.; Wittenberg,  P.H.;  et al.
H   Head Space Mass Spectrometric Analysis for Volatiles in
    Biological Specimens.
    J. Anal. Toxicol., 1(5):1 95-9 (1977)
    Ussing, H.H.
H   Determination in Tissues and Blood.
    Acta Physiol. Scand., 9:214-20 (1945)
    Usui, K.
H   Metabolism in the Brain.  I. Some Aspects of the Carbohydrates
    and Free Amino Acids in the Brain.
    Med. J. Shinshu Univ., 5:35-45 (1960)
                                 271

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    Utidjian, H.M.
H   Criteria Documents.  1. Recommendations for a Chloroform
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H   Health Aspects of Chloroform.  A Review.
    Drug Chem. Toxicol., l(3):259-75 (1978)
    Winters, W.D.
H   Effects of Drugs on the Electrical Activity of the Brain;
    Anesthetics.
    In:  Annual Review of Pharmacology and Toxicology, Vol. 16.
    Edited by Elliott, H.W.  Palo Alto:  Annual Reviews Inc.,  pp,
    413-26, 1976
                                 285

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    Wisingerova, E.; Sulova,  J.; Sassmannova,  E.
H   Inactivation of the Mycophage Activity of Lipid Solvents.
    Ann. Sclavo, 17(4):634-40 (Jul.-Aug.  1975)
    Witcher, C.E.; Cohen, E.N.;  Trudell,  J.R.
H   Chronic Exposure to Anesthetic Gases  in the Operating Room.
    Anesthesiology, 35:348-53 (1971)
    Withey, J.R.
H   The Comparative Pharmacoki.netics and Uptake of 4 Chlorinated
    Hydrocarbons from Vegetable Oil and Aqueous Solution.
    Toxicol. Lett. (AmstT), (Spec.  Issue 1):  92 (1980)
    Withey, J.R.;  Collins, B.T.
H   Chlorinated Aliphatic Hydrocarbons Used in the Foods  Industry;
    The Comparative Pharmacokinetics of Methylene  Chloride,
    1,2-Dichloroethane, Chloroform,  and Trichloroethylene after I.V.
    Administration in the Rat.
    J. Environ. Pathol. Toxicol.,  3(5-6):313-32 (1980)
    Woebkenberg, M.L.;  Doemeny, L.J.
H   NIOSH's Criteria for a Recomnended Standard-Occupational
    Exposure to Waste Anesthetic Gases and Vapors.
    Am. Ind. Hyg. Assoc. J., 39(7):598-9 (1978)
    Wolf, C.R.; Mansuy, D.;  Nastainczyk, W.;  et al.
H   The Reduction of Polyhalogenated Methanes by Liver Microsomal
    Cytochrome P450.
    Mol. Pharmacol., 13(4):698-705 (1977)
    Wolff, H.L.
H   The Cumulation of Drugs.  I.  Introduction and Definition.   II.
    Cumulative Poisoning by Barbital.   III.  Cumulative Poisoning by
    Chloroform.
    Arch. Int. Pharmacodyn. Ther.,  62(4):427-44,  487-95 (1939)
    Wolff, W.A.; Lumb, W.V.;  Ramsay,  M.K.
H   Effects of Halothane and  Chloroform Anesthesia on the Equine
    Liver.
    Am. J. Vet. Res. 28(126):1363-72  (1967)
                                286

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    Wolff, W.A.; Lumb, W.V.; Ramsay, M.K.
H   Comparison of Halothane and Chloroform Anesthesia in Horses.
    Am. J. Vet. Res., 29(l):125-32 (Jan. 1968)
    Wollman, H.
H   Effects of General Anesthesia on Cerebral Metabolism in Man.
    In:  Cellular Biology and Toxicity of Anesthetics.   Edited by
    Fink, B.R.  Baltimore:  Williams and Wilkins,  Co.,  pp.  64-8,  1972
    Woly, W.A.; Lumb, W.V.; Ramsay, M.K.
H   Effects of Halomethane and Chloroform Anesthesia on the Equine
    Liver.
    Am. J. Vet. Res., 28(126):1363-72 (1967)
    Woo, S.W.; Berlin, D.; Hedley-Whyte,  J.
H   Surfactant Function and Anesthetic Agents.
    J. Appl. Physiol., 26(5):571-7 (May 1969)
    Wood, J.M.; Kennedy, F.S.; Wolfe, R.S.
H   The Reaction of Multihalogenated Hydrocarbons with Free and
    Bound Reduced Vitamin B-12.
    Biochemistry, 7(5):1707-13 (May 1968)
    Wood, P.R.; Demarco, J.
E   Treatment of Groundwater with Granular Activated Carbon.
    J. Am. Waterworks Assoc., 71(11):674 (Nov.  1979)
    Woodbridge, D.D.;  Cooper, P.C.
E   Reduction of Chlorination by Irradiation.
    Proceedings:  American Water Works Association Disinfect.
    Seminar.  Denver,  CO, 1977.  Paper No.  10,  18 pp.  (1977)
    Wulfert, K.
H   Phosgene Formation on the Basis of Chlorinated Hydrocarbons.
    Nord. Hyg. Tidskr., 32:269-76 (1951)
    Wutscher, H.K.
E   Effect of Chloroform and Diethyl Ether on Cold Tolerance  of Sour
    Orange Seedlings.
    J. Rio Grande Val. Hortic. Soc., 25:22-5 (1971)
                                287

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    Xavier, L.
H   Halogenates in Obstetrics.
    Rev. Bras. Anestesiol, 20(4):523-42 (Oct.-Dec. 1970)  (For)
    Yamamo to, T.; Kawamura, Y.
H   Different Action of Sucrose and Chloroform to Gustatory
    Receptors of the Rat.
    J. Physiol. Soc. Jpn., 34(8-9):608 (1972)
    Yamamoto, T.; Kawamura, Y.
H   Chloroform Responses of the Chorda Tympani Nerve in the Rat.
    Physiol. Behav., 13(2):245-50 (1974)
    Yamamura, H.; Kato, S.
H   Effect of Anesthetics on the Various Cortical Systems.
    Int. Anesthesiol. Clin., 8(1):85-102 (1970)
    Yamazaki, I.
H   Influence of Low-Protein Diet on the Pathogenesis of Jaundice
    due to Chloroform Poisoning in Rats.
    Yonago Igaku Zasshi, 14(1):77-95 (1963)
    Yamazaki, I.; Gomyoda, M.; Tanaka, C.
H   Comparative Study of Toxic Jaundice Caused by Phosphor and
    Chloroform.
    Acta Pathol. Jpn., ll(4):203-4 (1961)
    Yamazaki, Y.
E   On the Degree of Photochemical Smog Problems.
    Tech. HumT Being, 4(9):48-50 (Sep.  1975)  (Jpn)
    Yanagihara, S.; Shimada, I.; Shinoyama,  E.;  et al.
E   Photochemical Reactivities of Hydrocarbons.
    Proc. 4th Int. Clean Air Congr., pp. 472-7  (1977)
    Yanagita, T.; Takahashi, S.
H   Dependence Liability of Several Sedative-Hypnotic Agents
    Evaluated in Monkeys.
    J. Pharmacol. Exp. Ther., 185(2):307-16 (May 1973)
                                288

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    Yang, J.; Speece, R.E.; Parkin, G.F.; et al.
    The Response of Methane Fermentation to Cyanide and Chloroform.
    Proceedings:  10th International IAWPR.  Toronto,  Canada,  Jun.
    23-27, 1980.
    Water Pollut. Res., (Part 3), 13:997 (1981)
    Yasunami, H.
H   The Effect of Alcohol, Chloroform, and Ether on the Growth and
    Radiosensitivity of Malignant Tumors.   I.  The Effect of Alcohol,
    Chloroform and Ether on the Growth of  a Rabbit Sarcoma.
    Jpn. J. Obstet. Gynecol., 23:214-7 (1940)
    Yohe, T.L.; Suffet, I.H.
    Specific Organic Removals by Granular Activated Carbon Pilot
    Contactors.
    Proceedings:  Annual Conference of the American Water Works
    Association.  (Part l):553-77 (1979)
    Yoshida, Y.
H   Carbon Dioxide Output of Popliteal Lymph Node of Rabbit
    Following Perfusion with Solution Containing Chloroform
    Arb. Dritten Abt. Anat. Inst. Kais. Univ. Kyoto, Ser.  D,
    6:170-% (1937)
    Yoshimura, N.
H   Metabolism of the Volatile Anesthetics.
    Masui, 26(10):1100-12 (Oct. 1977) (Jpn)
    Yoshitake, J.; Adachi, K.; Samejima,  T.
H   Effects of Chloroform, Diethyl Ether, and Fluothane Anesthesia
    on Lipid Peroxidation in the Rat Liver.
    Jpn. J. Anesthesiol., 21(8):758-64 (Aug.  1972)  (Jpn)
    Yosim, S.J.
    Disposal of Hazardous Wastes by Molten Salt Combustion.
    Technical Report: Toxic and Hazardous Waste Disposal  - New and
    Promising Ultimate Disposal Options,  4:227 (1980)
    Young, A.P.
H   Allosteric Effects of Volatile Anesthetics on the Membrane  Bound
    Acetylcholine Receptor.
    Conference: 9th Annual International Chemical Nuclear
    Association.  Symposium on Molecular and Cellular Biology.   Los
    Angeles, CA, Feb. 17-Mar. 21,  1980.
    J. Supramol. Struct., 9(Suppl. 4):73 (1980)
                                 289

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    Young, A.P.; Sigman, D.S.
H   Allosteric Facilitation of In Vitro Desensitization  of the
    Acetylcholine Receptor by Volatile Anesthetics.
    Prog. Anesthesiol., 2(Mol. Mech.  Anesth.):209-29 (1980)
    Young, A.P.; Brown, F.F.; Halsey,  M.J.;  et  al.
H   Volatile Anesthetic Facilitation of In Vitro Desensitization of
    Membrane-bound Acetylcholine Receptor from  Torpedo californica.
    Proc. Natl. Acad. Sci. U.S.A.,  75(9):4563-7 (1978)
    Young, D.R.
    Priority Pollutants in Municipal Wastewaters.
    Annu. Rep. - South Calif.  Coastal Water Res. Proj.,  pp.  103-12
    (1978)
    Young, J.S. Jr.; Singer, P.C.
    Chloroform Formation in Public Water Supplies;   A Case  Study.
    Proceedings:  97th Annual Conference of the American Water Works
    Association, 2:21-4 (1977)
    J. Am. Water Works Assoc., 71(2):87-95  (Feb. 1979)
    Young, L.Y.; Mitchell,  R.
    Negative Chemotaxis of  Marine Bacteria to Toxic Chemicals.
    Appl. Microbiol., 25(6):972-5 (Jun.  1973)
    Young, R.J.; Peters, C.J.;  Perry,  R.
    Factors Influencing the Formation  of  Haloforms  in the
    Chiorination of Humic Materials.
    Environ. Sci. Technol., 14(11):1391  (1980)
    Youssefi, M.
    Determination, Formation,  and Removal of Halogenated  Pollutants
    with Emphasis on Those Derived from Chlorination of Naturally
    Occurring Organic Compounds in Water.
    Dissertation for Ph.D. State University New Jersey (1978)
    Dissert. Abs., 39(11):5346B (May 1979)
    Youssefi, M.; Faust,  S.D.
    Absorption of Light Halogenated Hydrocarbons  and  Humic Acid in
    Water by Granular Activated Carbon.
    Abstr. Pap., Am. Chem. Soc., 176:70  (1978)
                                290

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    Youssefi, M.; Faust, S.D.; Zenchelsky,  S.T.
H   Rapid Determination of Light Halogenated Hydrocarbons  in Urine.
    Clin. Chem. (Winston-Salem, N.C.),  24(7):1109-11  (1978)
    Youssefi, M.J Zenchelsky, S.T.; Faust,  S.D.
E   Chlorination of Naturally Occurring Organic  Compounds in Water.
    J. Environ. Sci. Health, Part A, Environ.  Sci.  Eng.,
    13(8):629-37 (1978)
    Yuhi, K.
    Studies on the Chemical Estimation Method of Industrial
    Environment.  (II). Determination of Trichloroethylene,
    Chloroform, and Benzylchloride by Pyridine-Formalin Method.
    Jpn. J. Hyg., 21(6):407-9 (Feb. 1967) (Jpn)
    Yung, Y.L.; McElroy, M.B.;  Wofsy, S.C.
E   Atmospheric Halocarbons;  A Discussion with Emphasis on
    Chloroform.
    Geophys. Res. Lett., 2(9):397-9 (1975)
    Yung, Y.L.; McElroy, M.B.;  Wofsy,  S.C.
    Reply to Comment by A. Appleby,  D. Lilian,  and H.B.  Singh on
    "Atmospheric Halocarbons;  A Discussion with Emphasis  on
    Chloroform".
    Geophys. Res. Lett., 3(4):238 (1976)
    Zafar, B.J.
H   Mode of Muscle Relaxant Action of General Anesthetics.
    Pak. J. Med. Res., 6(4):278-92 (1967)
    Zaffiri, 0.; Rufinelli, A.R.;  Fusari,  0.;  et al.
H   Immediate Toxicity of Volatile Anesthetics.
    Minerva Anestesiol., 41(10):491-3 (Oct.  1975) (ita)
    Zakhari, S.; Levy, P.;  Leibowitz, M.;  et al.
H   Summary of Cardiac Output and Systemic Vascular Effects of
    Isopropanol, Fluorocarbons,  and Chlorinated Solvents.
    In:Isopropanol-Ketones Environment (Chapter 5).
    Cleveland:  CRC Press,  Inc., pp. 47-9, 1977
    Zaleska-Rutczynska, Z.; Krus, S.
H   Effect of Chloroform on Mouse Kidney.  I.  Strain-Specific
    Susceptibility.
    Patol. Pol., 23(2):181-4 (Apr.-Jun. 1972)  (Pol)
                                 291

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    Zaleska-Rutczynska, Z.; Krus, S.
H   Effect of Chloroform on Mouse Kidney.  II.  Resistance of F-l
    Generation of a Susceptible C3H-He Strain and a Resistant
    C57BL-6JN Strain.
    Patol. Pol., 23(2):185-8 (Apr.-Jun. 1972) (Pol)
    Zaleska-Rutczynska, Z.; Krus S.
H   Genetic Aspects of the High and  Low Sensitivity to Chloroform of
    Male Mice of Various Inbred Strains and Their Crosses.
    Pol. Med. Sci. Hist. Bull. Abstr.,  1(3):245-50 (May-Jun.  1973)
    Zamenhof, S.; Griboff, G.; Marullo, N.
H   Studies on the Resistance of Deoxyribonucleic Acids to Physical
    and Chemical Factors.
    Biochim. Biophys. Acta, 13:459-70 (1954)
    Zeller, H.
H   Testing Epidermal Sensitizing Substances in Animal Experiments.
    Arch. Exp. Pathol. PharmakolT, 232:239-40 (1957)
    Zeller, M.V.
H   Infrared Analysis of Anesthetic Chemicals.
    Am. Lab. (Fairfield, Conn.),  10(3):69-72,  74,  76-7 (1979)
    Zerbe, J.; Adamczewska, M.; Zawadzka,  H.
E   Determination of Trihalogen Derivatives of Methane in Water.
    Gaz, Woda Tech. Sanit., 53(5):143-4 (1979) (Pol)
    Zhdanov, G.G.
H   Effect of Anesthesia on the Liver (Histochemical Study).
    Khirurgiia (Moscow), 22(4):96-102 (Apr.  1969)  (Rus)
    Zhilis, B.G.
H   The Concentration of Chloroform in the Blood during Anesthesia
    and the Rate of Its Excretion from the Organism.
    Khirurgiia (Moscow), 42(8):79-84 (Aug. 1966) (Rus)
    Zhilis, B.C.; Uspenskii, L.S.; Strokov, V.A.
H   Certain Characteristics of the Effect of Fluothane,  Chloroform,
    and Ether on Renal Function.
    Sov. Med., (7):104-10 (Jul. 1975) (Rus)
                                 292

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    Zhorov, I.S.
H   Should Chloroform Anesthesia Be "Rehabilitated"?
    Eksp. Khir. Anesteziol., 9:60-8 (Jul.-Aug.  1964) (Rus)
    Zhorov, I.S.; Zhdanov, G.G.
H   Liver and Anesthesia.
    Eksp. Khir. Anesteziol.,  16(2):87-93 (1971)  (Rus)
    Zimner, C.; Marck, C.;  Guschlbauer,  W.
H   Magnetic Circular Dichroism Study of Analogs  of the DNA Binding
    Ligands Netropsin and Distamycin A.
    Spectrosc. Lett., 13(8):543-54 (1980)
    Zislin, B.D.; Kovalenko, O.V.
H   The Contractile Myocardial Capacity during Operations  on the
    Lungs under Different Methods  of Anesthesia.
    Grudn. Khir., 12(6): 95-9 (1970)
    Zoeteman, B.C.J.; Piet, G.J.;  Morra,  C.F.H.
    Sensorily Perceptible Organic  Pollutants in  Drinking Water.
    Pergamon Ser. Environ. Sci.,  Aquat.  Pollut.:  Transform.  Biol.
    Eff. 1977.  1:359-68 (1978)
    Zoeteman, B.C.J.; Harmsen,  K.L.;  Linder,  J.B.H.;  et  al.
    Persistent Organic Pollutants in  River Water and  Groundwater  of
    the Netherlands.
    Chemosphere,  9(4):231-49 (1980)
    Zogorski, J.S.; Allgeier,  G.D.;  Mullins,  R.L.  Jr.
    Removal of Chloroform from Drinking Water.
    Kentucky Water Resources Research Institute, Office  of Water
    Research and Technology
    U.S. NTIS, PB-285819, 98 pp.  (Jun. 1978)

    Zurio, N.; Metrico,  L.
    Simple Methods for Determination of Industrial Toxics  in Air.
    Med. Lav., 51:241 (1960)
                                293

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APPENDICES

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                                  Appendix I

                    Abstract Collections Manually Searched

Source                                              Period  of  Coverage

Chemical Abstracts*                                 (1930-1976)

Biological Abstracts*                               (1930-1970)

Excerpta Medica*
    Physiology, Biochemistry, Pharmacology,          (1965-1974)
      Toxicology
    Cancer                                          (1953-1974)
    Public Health, Social Medicine,  Hygiene          (1955-1974)
    Clinical Biochemistry                           (1969-1974)
    Pharmacology and Toxicology                     (1969-1974)
    Occupational Health                             (1972-1975)

Current Contents
    Life Sciences                                   (Oct.  1979-Mar.  1980)
                                                    (Apr.  1981-May  1981)
    Physical Sciences                               (Oct.  1979-Mar.  1980)
                                                    (Apr.  1981-May  1981)
    Agriculture                                     (Oct.  1979-Mar.  1980)
                                                    (Apr.  1981-May  1981)

Industrial Hygiene Digest                           (1943-1979)

Index Medicus*                                      (1930-1976)

Toxicology Research Projects Directory              (Oct.  1979-Mar.  1980)


*Recent issues searched on-line.

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  File
              Appendix  II

      On-Line Databases Searched

National Library of Medicine (MEDLARS)

                                Coverage Period of File
+ indicates that the database is continually updated.

Chemline                                            N/A

Toxline                                             1974+

Toxback                                             1965-1973

Cancerlit                                           Jan. 1963+

Cancerproj                                          1976-1978

Medline                                             Jan. 1977+

Back 66                                             Jan. 1966-Dec. 1968

Back 69                                             Jan. 1969-Dec. 1971

Back 72                                             Jan. 1972-Dec. 1974

Back 75                                             Jan. 1975-Dec. 1976

SDILINE                                             Present Month's Update

Toxicology Data Bank                                N/A

RTECS                                               1978 Edition
Search     Strategy

(RN)       67-66-3 (in appropriate files)
(RN)       8013-54-5 (in appropriate files)
ALL        chloroform
(TW)       trichloromethane
(TW)       trichloroform
All search statements were combined with the logical operator "or" before
printout.

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                                  Appendix  II

                      On-Line Databases  Searched  (cont'd)

                         Department of Energy (RECON)

  File                                              Coverage Period of File

+ indicates that the database is continually updated.

Water Resources Abstracts                           1968+

Environmental Mutagen Information Center            1969+

Environmental Teratogen Information Center          1975+


Search Strategy

IT= chloroform
RN= 67-66-3


Chemical Information System*

Structure and Nomenclature Search System (SANSS)
          (RN)  67-66-3


*Searched to obtain synonyms only


National Institute for Occupational Safety and Health

NIOSHTIC                                            1973+

+ indicates that the database is continually updated.

Search Strategy

chloroform
67-66-3

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                                 Appendix  II

                      On-Line Databases Searched  (cont'd)

                     Lockheed Information Systems  (DIALOG)
  File
Coverage Period of File
+ indicates Chat the database is continually updated
Agricola
Air Pollution Technical Information Center
Aquatic Sciences and Fisheries Abstracts
Biosis Previews
Chemical Abstracts Search
CA Patient Concordance
Commonwealth Agriculture Bureaux Abstracts
Chemical Industry Notes
Chemname
Claims/Chem
Comprehensive  Dissertation Abstracts
Conference Papers Index
Current Research Information System
EIS Industrial Plants
Enviroline
Environmental Periodicals Bibliography
Excerpta Medica
Food Science & Technology Abstracts
GPO Monthly Catalog
National Technical Information Service
Oceanic Abstracts
Pollution Abstracts
PTS Funk and Scott Indexes
PTS Federal Index
PTS Annual Time Series
PTS US Statistical Abstracts
Rubber & Plastics Research Association Abstracts
SciSearch
Smithsonian Science Information Exchange
Current Research Information System
Compendex
Inspec
Metadex
Pira
Claims/U.S. Patent
Claims /U.S. Patent
Claims/Class
CAB Abstracts
Aug. 1971+
1976-Sep. 1978
Jan. 1975+
1969+
1970+
Jan. 1972+
Jan. 1973+
1974+
N/A
1950-1970
1861+
1973+
Jul. 1974+
N/A
1971+
1973+
Jun. 1974+
1969+
Jul. 1973+
1964+
1964+
1970+
1972+
Oct. 1976+
Jul. 1971+
Jul. 1971+
1972+
Jan. 1974+
Most Recent 2 Yrs,
Jul. 1974+
1970+
1969+
1966+
1975+
Abstracts Weekly
1971 +
Oct. 1975+
1973+

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                                  Appendix II

                      On-Line  Databases  Searched  (cont'd)

                     Lockheed  Information Systems (DIALOG)
Search Strategy
chlororm
trichloromethane
tri(W)chloro(W) methane
trichloro(W)methane
tri(W)chloromethane
R(W)20
trichcloroform
tri(W)chloroform
67-66-3 (in appropriate files)
8013-54-5 (in appropriate files)

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Database
              Appendix II

  On-Line Databases Searched (cont'd)

Systems Development Corporation (OMIT)

                                Coverage Period of File
+ indicates that the database is continually updated.
Apilit

Apipat

Chemdex

Crecord

Fedreg

Libcon

Paperchem

P/E News

Safety Science

Titus

World Patent Index

Search Strategy
(RN)67-66-3  (in appropriate files)
(RN)   8013-54-5 (in appropriate files)
chloroform
trichlororaethane
R20
trichloroform
                                1974+

                                1964+

                                1972+

                                1976+

                                Mar. 1977+

                                1968+

                                1968+

                                1975

                                Jun. 1975+

                                1970+

                                1963+
All search statements were combined with the logical operator "or" before
printout.

-------