v>EPA United States Environment*! Protection Agency Off ic« of Pesticides and Toxic Substances Washington. DC 20460 EPA 560/7-81411 July 1981 Toxic Substances Environmental and Health Aspects of Chloroform A Comprehensive Bibliography of Published Literature 1930- 1981 ------- &EPA United States Environmental Protection Agency Office of Pesticides and Toxic Substances Washington, DC 20460 OTS-TIC REPORT FILE EPA 68-01-6021 Rept A July 1981 Toxic Substances Environmental and Health Aspects of Chloroform A Comprehensive Bibliography of Published Literature 1930- 1981 ------- 50272-101 REPORT DOCUMENTATION ;.i._ REPORT NO. PAGE I EPA 560/7-81-011 3. Recipient's Accession No. 4. Trtle and Subtitle Environmental and Health Aspects of Chloroform, A Comprehensive Bibliography, 1930 to 1981. 5. Report c.te preparation June 1981 7. Author(s) 8. Performing Organization Rept. No. 9. Performing Organization Name and Address Tracer Jitco, Inc. 1776 East Jefferson Street Rockville., Maryland 20852 10. Project/Task/Work Unit No. Technical Directive 2 11. Contract(C) or Grant(G) No. 68-01-5836 (G) 12. Sponsoring Organization Name and Address Environmental Protection Agency, Office of Pesticides and Toxic Substances, Management Support Division, 401 M Street SW, Washington, D.C. 20460 13. Type of Report & Period Covered Final Report 1930-1981 14. IS. Supplementary Notes 16. Abstract (Limit: 200 words) This document is a bibliography of published citations on health and environmental aspects of Chloroform (Chemical Abstacts Service Registry Number 67-66-3) for the period 1930 to May 1981. The citations have been selected from a thorough literature search, and broadly classified as having primarily environmental or biological emphasis. The sources used in the search are identified, and for the portion performed on line, the search strategies are also included. 17. Document Analysis a. Descriptors Bibliographies; Literature Surveys; Environments; Public Health; Pollution; Toxicology. b. Identlfiers/Ooen-Ended Terms Literature Search; Literature Review; Health Effects; Environmental Effects; Chloroform; 67-66-3 c. COSATI Field/Group 18. Availability Statement ! 19. Security Class (This Report) Release unlimited i Unclassified | 20. Security Class (This Page) ' Unclassified 21. No. of Pages 22. Price (See ANSI-Z39.1B) See Instructions on Reverse OPTIONAL FORM 272 (4-77) (Formerly NTIS-35) Department of Commerce ------- EPA Report No. 560/7-81-011 July 1981 ENVIRONMENTAL AND HEALTH ASPECTS OF CHLOROFORM A Comprehensive Bibliography of Published Literature 1930 - 1981 by Management Support Division Information Support Services Branch Office of Toxic Substances Washington, D.C. 20460 68-06-5836 Project Officers Michael Weaver, Delores Evans Management Support Division Office of Toxic Substances Washington, D.C. 20460 OFFICE OF TOXIC SUBSTANCES U.S. ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20026 ------- Preface This bibliography was created from a literature search performed under the auspices of the Management Support Division, Information Support Services Branch for the Assessment Division, Chemical Review and Evaluation Branch; both of the Office of Toxic Substances. The search was intended to provide partial support for the preparation of a Preliminary Risk Assessment on chloroform (67-66-3). This assessment reviews and evaluates the available significant economic and adverse effects data from both published and unpublished sources on a substance selected as being potentially hazardous to human health or the environment. The subject coverage of the assessment is broader than this bibliography which includes only published environmental and biological information. The bibliography does not include all information available to the review branch. Although it is not an authoritative source list for Preliminary Risk Assessments, it does represent a comprehensive and systematic search of the literature and subsequent selection of citations that pertain to health and the environment. The limits of the search are fully described in this document and its appendices. ------- Introduction 1. The Search This bibliography is a compilation of citations retrieved during a thorough review of the national and international literature on chloroform (Chemical Abstracts Service Registry Number 67-66-3) cited between 1930 and April 1980. The supporting search was performed at the request of the Assessment Division/Chemical Review and Evaluation Branch by the Management Support Division/Information Support Services Branch, within the Office of Toxic Substances. 1.1. Scope To insure that the search was comprehensive, a variety of sources were examined, including the following: o On-line databases from major vendors of bibliographic information. o On-line databases from various agencies of the United States Government. o Manually searched national and international indices and abstract collections of scientific literature. o Reference sections of major review articles, criteria documents, monographs, and reports. o Selected handbooks. (A complete listing of sources consulted can be found in Appendices I and II). The emphasis of this bibliography is on the primary literature except for the handbook information presented in Section II and a few secondary sources selected because they contain unique or well-summarized information on the chemical. Subsequent to the main search, which was completed in April 1980, and using the same strategy, update searches were performed during the period from April 1980 to May 1981 on all the on-line databases initially searched. In addition, the April 1981 and May 1981 issues of Current Contents (Life Sciences, Agriculture, Biology, and Environmental Sciences series) were screened to retrieve citations which may not have been entered into the on-line files at the time of the final update searches. 11 ------- Because the overall requirement of the search request for this project was broader than the health and environmental aspects of the chemical, a wider range of databases was searched than might normally be expected for this bibliography. However, only health and environmental aspects were selected regardless of the data source examined. The total complement of databases searched is listed in the appendices for the user's reference. 1.2. Strategy The search requirement demanded high recall of information dealing with chloroform; precision was a secondary consideration. EPA decided to retrieve all citations that contained the term chloroform or its synonyms in any searchable fields and to select relevant citations by a manual screen. The Chemical Abstract Service registry number (CAS RN) and systematic names and synonyms that could be identified from CHEMLINE (National Library of Medicine); CHEMDEX (System Development Corporation); CHEMNAME, CHEMSEARCH, and CHEMSIS (Lockheed Information System); SANSS (NIH/EPA Chemical Information System); and RTECS (NIOSH Registry of Toxic Effects of Chemical Substances) were used in the search on databases. For on-line searching, the names were divided into significant fragments and entered according to the conventions of the individual databases. Chemical terms used in this search were as follows: CAS RN: 67-66-3 CAS ON: 8013-54-5 chloroform (8CI) methane, trichloro- (9CI) R20 (refrigerant) R20 (VAN) trichloroform trichloromethane No additional modifiers or keywords were used to limit information retrieved in any database for this chemical because comprehensive retrieval was desired. Complete search strategies are listed in Appendix II. Use/Application categories were not used as search terms because EPA decided to select only terms that specifically mentioned the chemical or its synonyms. Indexing policy, keyword entry, and abstracting techniques usually assure retrieval of specific information on individual chemicals if they are discussed significantly in general articles or reviews. The user can be assured, therefore, that each citation listed in this bibliography contains substantive information on the subject chemical. ill ------- Manual sources, indices, and abstract collections usually employ their own unique indexing schemes for chemical information, so it is difficult to describe a standard search strategy for these information tools. However, in all cases, the most specific indexing terms available in the source were used to identify citations on the subject chemical. 1.3. Selection of Citations Citations were selected for inclusion in this bibliography based on their relevance to the following topics: o Toxicity Adverse and toxic effects on any biological systems, structural and functional changes in organs and tissues of all vertebrate and invertebrate species, test methods used for determination of toxicity, and bioassay studies. o Physiology Absorption, distribution, transport, metabolism, and elimination in all species; techniques for measurement of tissue and organ residues; interactions with endogenous substances. o Epidemiology Exposure data, morbidity, and mortality rates for general and occupational populations. o Environmental Significance Environmental distribution in air, soil, and water; sources of pollution; ecological effects on microorganisms, insects, plants, and wildlife; biodegradation and bioconcentration; analytical techniques for sampling and measurement in the environment. o Safety, Control, and Regulations Disposal hazards; Federal, local, and international controls, recommendations, and regulations. These are the broad specifications for inclusion in this bibliography. Because any literature selection process involves subjectivity and judgement, precise definitions are difficult. The general guiding requirement for inclusion is that citations must pertain to the biological or environmental aspects of the chemical. The following information is not included in this bibliography: news items; brief announcements and Federal Register notices; reports of on-going research which have not yet been published or any other unpublished information; draft reports; and private communications. ------- 2. Organization of Bibliography This bibliography is organized into three major sections. 2.1. Section Titles Section I Handbook information Section II Citations from the primary literature Section III Appendices listing specific sources used and exact search strategies employed 2.2. Citation Format In Section II citations from on-line and manually searched abstract collections are arranged alphabetically by author. Personal names are entered with the last name first followed by the first two initials. Second and third authors' names are separated from the first author and each other by a semicolon. Up to three personal names are used; if there are more than three authors, the remaining are listed as "et al." If an author has written more than one article, citations are arranged in ascending chronological order. If authors and date are identical, citations are arranged alphabetically by title of the article. Single author entries are listed first, followed by two, then three author entries. Patents are arranged alphabetically by assignee name. All government publications are listed by the sponsoring government agency. Government or corporate names are written in full form. No acronyms are used. The country of origin is listed first, followed by the organizational hierarchy of the sponsoring group listed in descending hierarchical order. If the performing organization or individual author is known, they are listed on separate lines below the government sponsor. Example: NIOSH publication: United States. Department of Health, Education and Welfare. Public Health Service. Center for Disease Control. National Institute for Occupational Safety and Health Tracer Jitco, Inc. Brown, R.A.; Smith S.S. Corporate documents with no specific author are listed in alphabetical order according to the first significant word of the organization name. e.g., DuPont de Nemours, E.I. and Company ------- 2.3. Literature Cited The following kinds of literature are cited in this bibliography: journal articles, government reports, patents, organization and corporate reports, books, manufacturer's literature, conference proceedings, and dissertations. In each case an attempt has been made to supply the user with enough information so that the hard copy of the document may be easily obtained. Journal titles are abbreviated according to the style in the Chemical Abstracts Service Source Index (CASSI), The American Chemical Society, Columbus, OH, 1980 and its corresponding guide, Bibliographic Guide for Editors and Authors, The American Chemical Society, Washington, DC, 1974. All foreign titles have been translated into English. Foreign language articles are indicated by the appropriate three letter language abbreviation in parentheses at the end of the source information. 2.4. Categorization of Citations In order to make this bibliography a more useful tool for separate user groups, most citations are marked with the category code E or H. E = Environmental Aspects, i.e., the major content of the document pertains to the chemical in the open environment: its distribution, degradation, environmental chemistry and analysis; effect on ecosystems; effect on flora and fauna, including laboratory research, when emphasis is on environmental considerations rather than prediction of human effects, environmental chemistry, and analysis. H = Health Aspects, i.e., the major content of the document concerns known health effects, predictive laboratory research, and animal studies as relates to human health effects, human exposure, and epidemiological studies. A decision was made based on the abstract, and in some cases the entire document, to categorize according to what appeared to be the major purpose of the study. In a few cases neither category applies. Those citations were left unclassified. VI ------- HANDBOOK AND DATABANK INFORMATION ------- 3. Handbook and Databank Information 3.1. Summary Databanks for Health Effects Data (Information found) United States. Department of Health and Human Services. Public Health Service. Center for Disease Control. National Institute for Occupational yes Safety and Health Registry of Toxic Effects of Chemical Substances. Cincinnati, OH: NIOSH, 1980 United States. Department of Health and Human Services. Public Health Service. National Institutes of Health. National Library of Medicine yes Toxicology Data Bank. Bethesda, MD 1980 ------- 3.2. Handbooks Searched for Health Effects Source Location of Information Browning, E. Toxicity and Metabolism of Industrial Solvents, New York: Elsevier Publishing Co., 1963 No pertinent information found Browning, E. Toxicity of Industrial Metals. New York: Appleton-Century-Crofts, 1969 No pertinent information found Dittmer, D.S., Editor Handbook of Toxicology, V. - Fungicides. Philadelphia: W. B. Saunders Company, 1959 No pertinent information found Fishbein, L. Potenial Industrial Carcinogens and Mutagens. New York: Elsevier Scientific Publishing Co., 1979 pp. 212-7 Fishbein, L.; Flamm, W.G.; Falk, H.L. Chemical Mutagens. New York: Academic Press, 1970 No pertinent information found Goodman, L.S.; Oilman, A., Editors The Pharmacological Basis of Therapeutics. New York: Macmillan Publishing Co., Inc., 1975 p. 96 Patty, F.A., Editor Industrial Hygiene and Toxicology. New York: Interscience Publishers, 1963 pp. 1259-62 Plunkett, E.R. Handbook of Industrial Toxicology. New York: Chemical Publishing Co., Inc., 1976 pp. 101-2 Sax, N.I. Dangerous Properties of Industrial Materials. New York: Van Nostrand Reinhold Co., 1979 p. 493 Searle, C.E., Editor Chemical Carcinogens. Washington, DC: American Chemical Society, 1976 pp. 158-9 ------- 3.2. Handbooks Searched for Health Effects (cont'd) Source Shepard, T.H. Catalog of Teratogenic Agents. Baltimore, MD: The Johns Hopkins University Press, 1976 Location of Information No pertinent information found Spector, W.S., Editor Handbook of Toxicology, V. I. - Acute Toxicities, Philadelphia: W. B. Saunders Company, 1956 pp. 68, 328 Spector, W.S., Editor Handbook of Toxicology, V. II. - Antibiotics. Philadelphia: W.B. Saunders Company, 1957 No pertinent information found Spector, W.S., Editor Handbook of Toxicology, V. III. - Insecticides. Philadelphia: W.B. Saunders Company, 1959 No pertinent information found Sunshine, I., Editor CRC Handbook Series in Analytical Toxicology. Boca Raton, FL: CRC Press, Inc., 1979 pp. 400-1 United Nations. International Agency for Research on Cancer IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Lyon, France: IARC 1:61-5 20:401-27 United States. Department of Health and Human Services. Public Health Service. Center for Disease Control. National Institute for Occupational Safety and Health NIOSH Criteria Documents. Cincinnati, OH: NIOSH Entire document United States. Department of Health and Human Services. Public Health Service. Center for Disease Control. National Institute for Occupational Safety and Health Registry of Toxic Effects of Chemical Substances. Cincinnati, OH: NIOSH, 1980. p. 411 ------- 3.2. Handbooks Searched for Health Effects (cont'd) Source United States. Department of Health and Human Services. Public Health Service. National Institutes of Health. National Cancer Institute NCI Carcinogens Bioassay Reports. Springfield, VA: National Technical Information Service Location of Information Entire document United States. Department of Health and Human Services. Public Health Service. National Institutes of Health. National Cancer Institute Survey of Compounds Which Have Been Tested for Carcinogenic Activity. Bethesda, MD: NCI, 1978 1961-7, pp. 200-2 1978, p. 71 United States. Environmental Protection Agency EPA Publications Bibliography. Washington, DC, EPA 77(2):37 78(1):42 79(2):60-1 ------- 3.3. Handbooks Searched for Environmental Effects Source Applegate, V.C.; Ho we 11, J.H.; Hall, A.E.; et al. Toxicity of 4,346 Chemicals to Larval Lampreys' and Fishes: Special Scientific Report. Fisheries No. 207, Washington, DC, 1957 Location of Information No pertinent information found McKee, J.E.; Wolf, H.W., Editors Water Quality Criteria, 2nd Edition. California State Water Resources Control Board, 1963 p. 163 Ryckman, D.W.; Prabhakara Rao, A.V.S.; Buzzel, J.C. Behavior of Organic Chemicals in the Aquatic Environment. Washington, DC: Manufacturing Chemists' Association, 1966 No pertinent information found United States. Environmental Protection Agency pp. 69-72 Review of the Environmental Fate of Selected Chemicals. Springfield, VA: National Technical Information Service, 1977 United States. Environmental Protection Agency Review of the Environmental Fate of 129 Priority Pollutants. Springfield, VA: National Technical Information Service, 1977 Chap. 40, PP. 1-9 Verschueren, K. Handbook of Environmental Data on Organic Chemicals, New York: Van Nostrand Reinhold Co., 1977 pp. 178-9 ------- 3.4. Handbooks Searched for Physical and Chemical Properties Source Location of Information Aldrich Chemical Company, Inc. Aldrich Catalog Handbook of Fine Chemicals. 1981-2. Milwaukee, WI: Aldrich Chemical Co., 1980 p. 213 Bennet, H., Editor Concise Chemical and Technical Dictionary. New York: Chemical Publishing Co., Inc., 1974 p. 240 Dreisback, R.R. Physical Properties of Chemical Compounds. Washington, DC: American Chemical Society, 1959 p. 196 Grasselli, J.G.; Ritchey, W.M., Editors CRC Atlas of Spectral Data and Physical Constants for Organic Compounds. Boca Raton, FL: CRC Press, 1975 Vol. Ill, p. m-381 Grayson, M., Editor Kirk-Othmer Encyclopedia of Chemical Technology. New York: Interscience Publishers, 1979 Vol. II, p. 397 Vol. V, pp. 92-4, 97-8, 119-27 Hawley, G.G. The Condensed Chemical Dictionary. New York: Van Nostrand Reinhold Co., 1977 p. 197 Kortum, G.; Vogel, W. Dissociation Constants of Organic Acids in Aqueous Solution. London: Butterworths, 1961 No pertinent information found Leo, A.; Hansch, C.; Elkins, D. Chemical Reviews. Claremont, CA: Department of Chemistry, Pomona College, 1971 p. 555 Linke, W.F. Solubilities of Inorganic and Metal-Organic Compounds. New York: D. Van Nostrand Co., Vol. I. 1958, Vol. II. 1965 No pertinent information found ------- 3.4. Handbooks Searched for Physical and Chemical Properties (cont'd) Source Location of Information Mark, H.F.; Gaylord, N.G.; Bikales, N.M., Editors No pertinent Encyclopedia of Polymer Science and Technology. information found New York: Interscience Publishers, 1964 Perry, R.H.; Chilton, C.H., Editors pp. 210-4 Chemical Engineers Handbook. New York: McGraw-Hill Book Co., 1973 Pollock, J.R.; Stevens, R., Editors p. 627 Dictionary of Organic Compounds. London: Eyre and Spottiswoode Publishers, Ltd., 1965 Stephen, H.; Stephen, T.; Editors No pertinent Solubilities of Inorganic and Organic Compounds. information found New York: The Macmillan Co., 1963 Weast, R.C., Editor p. 375 CRC Handbook of Chemistry and Physics. Boca Raton, FL: CRC Press, 1979 Windholz, M., Editor p. 272 The Merck Index. Rahway, NJ: Merck and Co., Inc., 1976 ------- CITATIONS FROM THE LITERATURE ------- Abajian, J.; Brazell, E. H Refractory Period and Conduction Time Studies with Ethyl Ether, Cyclopropane, and Chloroform Using Turtle Ventricle Strips. Fed. Proc., 10(1):275 (1951) Abelin, I. H Adrenal Function and Cholesterol Metabolism in Narcosis. Helv. Physiol. Pharmacol. Acta., 4:1-9 (1946) Abreu, B.E.; Auerbach, S.H.; Thuringer, J.M.; et al. H Chronic and Delayed Toxic Effects of Certain Saturated and Unsaturated Halogenated Hydrocarbons in White Rats and White Mice. J. Pharmacol. Exp. Therap., 80:139-45 (1944) Acierno, L.J.; DiPalma, J.R. H The Effects of Ether, Cyclopropane, and Chloroform on the Isolated Auricle of the Cat. Anesthesiology, 12:567-73 (1951) Adams, W.L. The Determination of Chloral Hydrate, Chloroform, and Related Substances in the Blood. J. Pharmacol. Exp. Ther., 74:11-7 (1942) Adey, G.D.; Williamson, F.B. H The Mechanism of Action of Anaesthetic Agents; A Model Simulating Enzyme Catalysis. Br. J. Anaesth., 51(6):565-6 (1979) Adey, G.j Wardley-Smith, B.; White, D. Mechanism of Inhibition of Bacterial Luciferase by Anaesthetics, Life Sci., 17(2):1849-54 (Dec. 15, 1975) Adriani, J.; Rovenstine, E.A. H The Effect of Anesthetic Drugs upon Bronchi and Bronchioles of Excised Tissue. Anesthesiology, 4:253-62 (1943) Afghan, B.K.; MacKay, D. (eds.) Hydrocarbons and Halogenated Hydrocarbons in the Aquatic Environment. New York: Plenum Press, 1980 11 ------- Agostino, D.; Cliffton, E.E. H Anesthetic Effect on Pulmonary Metastases in Rats. Development of Metastases of Walker 256 Carcinosarcoma. Arch. Surg. (Chicago), 88:735-9 (May 1964) Agustin, J.S.; Lim-Sylianco, C.Y. H Mutagenic and Clastogenic Effects of Chloroform. BullT Philipp. Biochem. Soc., l(2):17-23 (1978) Ahmad, M.M.; Jahangeer, S.; Mir, A.K. H Effect of Different Anesthetics on Plasma Glucose Levels in Uromastyx hardwickii Gray. Biologia (Lahore), 23(1):17-21 (1977) Ahmed, A.E.; Kubic, V.C.; Anders, M.W. H Metabolism of Haloforms to Carbon Monoxide. I. In Vitro Studies. Drug Metab. Dispos., 5(2):198-204 (1977) Ahmed, S.M.; Gupta, M.R. H Stabilization of Pyrethrins for Prolonged Residual Toxicity. Part I; Screening of Various Ingredients. Pyrethrum Post, 13(3):82-8 (1976) Ahr, H.J.; King, L.J.; Nastainczyk, W.; et al. H The Mechanism of Chloroform and Carbon Monoxide Formation from Carbon Tetrachloride by Microsomal Cytochrome P-450. Biochem. Pharmacol., 29(20):2855-61 (1980) Ai, N.; Takagi, S.F. H The Effect of Ether and Chloroform on the Olfactory Epithelium. Jpn. J. Physiol., 13(5):454-65 (Oct. 15, 1963) Alavanja, M.; Goldstein, I.; Susser, M. H A Case Control Study of Gastrointestinal and Urinary Tract Cancer Mortality and Drinking Water Chlorination. Water Chlorination, 2:395-409 (1978) Al-Azzawi, H.T.; Steward, P.J. H The Effects of Lethal Procedures on the Histochemical Localization of Acid Hydrolases. Histochemie, 37(2):187-95 (Oct. 26, 1973) 12 ------- Albert, R.E.; Burns, F.J.; Altshuler, B. H Reinterpretation of the Linear Nonthreshold Dose-Response Model in Terms of the Initiation-Promotion Mouse Skin Tumorigenesis. In: Advances in Modern Toxicology. Vol. 1. New Concepts in Safety Evaluation. Part 2. Edited by Melman, M.A.; Shapiro, R.E.; Blumenthal, H. Washington, DC: Hemisphere Publishing Corp., pp. 89-95, 1979 Alcala, H.; Lertratatanangkoon, K.; Stenbach, W. H The Purkinje Cell in Dilantin Intoxication; Ultrastructural and Golgi Studies Preliminary Report. Symposium: Epilepsy International Symposium. Vancouver, Canada, 1978. In: Advances in Epileptology. Edited by Wada, J.A.; Penry, J.K. New York: Raven Press, pp. 519, 1980 Aldridge, M.H.; Pressley, T.A.; Chapin, C.; et al. Characterization of Nonvolatile Organic Material during Physical-Chemical Treatment of the District of Columbia Raw Wastewater. U.S. NTIS, PB-280267, 34 pp. (1976) Alekhina, R.P.; Piker, E.G.; Likhtenshtein, A.V. H Losses of Nucleic Acids of Animal Origin in the Process of Their Deproteinization by Phenol and Chloroform. Bioklhimiia, 38(4):779-84 (Jul.-Aug. 1973) Alekseev, A.E. H Significance of the Central Nervous System in Pharmodynamics of Some Vapor-Phase Drugs Administered in Respired Air. Farmakol. Toksikol., 18(6):22-4 (1955) Alexsanderov, I.S. H Alteration of the Eye-Heart Reflex under Influence of Narcotics. Fiziol. Zhur., 37:64-8 (1951) Alha, A.; Korte, T. H Gas Chromatographic Determination of Drugs in Post-Mortem Blood. Ann. Med. Exp. Biol. Fenn., 50(4):175-9 (1972) Allen, J.G.; Kable, V.; Livingston, H.M. H Effects of Anesthetic Agents on Prothrombin Concentration. Anest. Analg., 20:156-9 (1941) 13 ------- Allgeier, G.D.; Mullins, R.L. Jr.; Wilding, D.A.; et al. Tribalomethane Levels at Selected Water Utilities in Kentucky, U.S.A. In: Hydrocarbons and Halogenated Hydrocarbons in the Aquatic Environment. Edited by Afghan, B.K.; MacKay, D. New York: Plenum Press, pp. 473-90, 1980 Allison, A.C.; Hulands, G.H.; Nunn, J.F.; et al. H The Effect of Inhalational Anaesthetics on the Microtubular System in Actinosphaerium nucleofilum. J. Cell. Sci., 7(2):483-99 (Sep. 1970) Allison, S.C.; Doran, W.R.; John, C.H.; et al. H Preliminary Investigation of Levels of Airborne Solvents and Other Conditions Found in Nine Coin Operated Dry Cleaning Establishments. Environ. Health, 59-62 (Mar. 1976) Allott, P.R.; Steward, A.; Mapleson, W.W. H Pharmacokinetics of Halothane in the Dog. Comparison of Theory and Measurement in Individuals. Br. J. Anaesth., 48(4):279-95 (Apr. 1976) Allott, P.R.; Steward, A.; Hook, V.; et al. H Variation with Temperature of the Solubilities of Inhaled Anesthetics in Water, Oil, and Biological Media. J. Anaesth., 45(3) .-294-300 (1973) Almeida, J.J. H Our Experience with the Use of Chloroform, a Current Re-evaluation. Rev. Esp. Anestesiol. Reanim., 13(l):27-33 (Jan. 1966) Almersjo, 0. H Influence of Halothane Anesthesia on the Normal Liver and the Liver Subjected to Partial Hepatectomy or Stimulated Drug Metabolism. Comparative Study of the Influence of Halothane, Gaseous Carbon Tetrachloride, Chloroform, and Nitrous Oxide in the Rat. Acta Chir. Scand., Suppl., (416):74-83 (1971) 14 ------- Alpert, L.I.; Mitra, S.K. H Anatomic and Functional Circulatory Changes in Experimental Cirrhosis. Am. J. Pathol., 48(4):579-95 (Apr. 1966) Althausen, T.C.; Thoenes, E. H Influence on Carbohydrate Metabolism of Experimentally Induced Hepatic Changes. Arch. Int. Med., 50:257-68 (1932) Alto, I.E.; Lee, S.L.; Dhalla, N.S. E Changes in Heart Membrane Calcium Accumulation due to Anesthetic Agents. J. Mol. Cell. Cardiol., 9(12 Suppl.ll) (1977) Altura, B.M.; Alturn, B.T.; Carella, A.; et al. H Vascular Smooth Muscle and General Anesthetics. Fed. Proc. (U.S.A.) 39(5):1584-91 (1980) Alumot, E.; Bielorai, R. H Residue of Fumigant Mixture in Cereals Fumigated and Aired at Two Different Temperatures. J. Agric. Food Chem., 17(4):869-70 (1969) Amaranath, L.; Andersen, N.B. H The Effects of Anesthetics on Permeability to Water of the Inactivated Toad Bladder. Anesthesiology, 40(2):168-74 (Feb. 1974) Amasio, C. H Diphosphopyridine Nucleotide in Chloroform Toxicosis. Vitaminologia, 16:57-9 (1958) American Academy of Pediatrics. Committee on Environmental Hazards H Carcinogens in Drinking Water. Pediatrics, 57(4):462-4 (1976) American Conference of Governmental Industrial Hygienists H Chloroform. In: TLVs (Threshold Limit Values) for 1961. Ind. Hyg. Digest, 25(6) :I (1961) 15 ------- American Conference of Governmental Industrial Hygienists H Chloroform. In: TLVs (Threshold Limit Values) for 1962. Ind. Hyg. Digest, 26(10):II (1962) American Conference of Governmental Industrial Hygienists H Chloroform. In: TLVs (Threshold Limit Values) for 1963. Ind. Hyg. Digest, 27(9):VI (1963) American Conference of Governmental Industrial Hygienists H Chloroform. In: TLVs (Threshold Limit Values) for 1964. Ind. Hyg. Digest, 28(9):II (1964) American Conference of Governmental Industrial Hygienists H Chloroform. In: TLVs (Threshold Limit Values) for 1965. Ind. Hyg. Digest, 29(9):III (1965) American Conference of Governmental Industrial Hygienists H Chloroform. In: TLVs (Threshold Limit Values) for 1966. Ind. Hyg. Digest, 30(9):III (1966) American Conference of Governmental Industrial Hygienists H Chloroform. In: TLVs (Threshold Limit Values) for 1967. Ind. Hyg. Digest, 31(9) :III (1967) American Conference of Governmental Industrial Hygienists Chloroform. In: TLVs (Threshold Limit Values) for 1968. Ind. Hyg. Digest, 32(9):IV (1968) American Conference of Governmental Industrial Hygienists H Chloroform. In: TLVs (Threshold Limit Values) for Airborne Contaminants Adopted by ACGIH for 1969 and Intended Changes, Ind. Hyg. Digest, 33(9):VI (1969) 16 ------- American Conference of Governmental Industrial Hygienists H Threshold Limit Values of Airborne Contaminants Adopted by ACGIH, 1969. Washington, DC: Government Printing Office, p. 7, 1969 American Conference of Governmental Industrial Hygienists H Chloroform. 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Lav., 51:241 (1960) 293 ------- APPENDICES ------- Appendix I Abstract Collections Manually Searched Source Period of Coverage Chemical Abstracts* (1930-1976) Biological Abstracts* (1930-1970) Excerpta Medica* Physiology, Biochemistry, Pharmacology, (1965-1974) Toxicology Cancer (1953-1974) Public Health, Social Medicine, Hygiene (1955-1974) Clinical Biochemistry (1969-1974) Pharmacology and Toxicology (1969-1974) Occupational Health (1972-1975) Current Contents Life Sciences (Oct. 1979-Mar. 1980) (Apr. 1981-May 1981) Physical Sciences (Oct. 1979-Mar. 1980) (Apr. 1981-May 1981) Agriculture (Oct. 1979-Mar. 1980) (Apr. 1981-May 1981) Industrial Hygiene Digest (1943-1979) Index Medicus* (1930-1976) Toxicology Research Projects Directory (Oct. 1979-Mar. 1980) *Recent issues searched on-line. ------- File Appendix II On-Line Databases Searched National Library of Medicine (MEDLARS) Coverage Period of File + indicates that the database is continually updated. Chemline N/A Toxline 1974+ Toxback 1965-1973 Cancerlit Jan. 1963+ Cancerproj 1976-1978 Medline Jan. 1977+ Back 66 Jan. 1966-Dec. 1968 Back 69 Jan. 1969-Dec. 1971 Back 72 Jan. 1972-Dec. 1974 Back 75 Jan. 1975-Dec. 1976 SDILINE Present Month's Update Toxicology Data Bank N/A RTECS 1978 Edition Search Strategy (RN) 67-66-3 (in appropriate files) (RN) 8013-54-5 (in appropriate files) ALL chloroform (TW) trichloromethane (TW) trichloroform All search statements were combined with the logical operator "or" before printout. ------- Appendix II On-Line Databases Searched (cont'd) Department of Energy (RECON) File Coverage Period of File + indicates that the database is continually updated. Water Resources Abstracts 1968+ Environmental Mutagen Information Center 1969+ Environmental Teratogen Information Center 1975+ Search Strategy IT= chloroform RN= 67-66-3 Chemical Information System* Structure and Nomenclature Search System (SANSS) (RN) 67-66-3 *Searched to obtain synonyms only National Institute for Occupational Safety and Health NIOSHTIC 1973+ + indicates that the database is continually updated. Search Strategy chloroform 67-66-3 ------- Appendix II On-Line Databases Searched (cont'd) Lockheed Information Systems (DIALOG) File Coverage Period of File + indicates Chat the database is continually updated Agricola Air Pollution Technical Information Center Aquatic Sciences and Fisheries Abstracts Biosis Previews Chemical Abstracts Search CA Patient Concordance Commonwealth Agriculture Bureaux Abstracts Chemical Industry Notes Chemname Claims/Chem Comprehensive Dissertation Abstracts Conference Papers Index Current Research Information System EIS Industrial Plants Enviroline Environmental Periodicals Bibliography Excerpta Medica Food Science & Technology Abstracts GPO Monthly Catalog National Technical Information Service Oceanic Abstracts Pollution Abstracts PTS Funk and Scott Indexes PTS Federal Index PTS Annual Time Series PTS US Statistical Abstracts Rubber & Plastics Research Association Abstracts SciSearch Smithsonian Science Information Exchange Current Research Information System Compendex Inspec Metadex Pira Claims/U.S. Patent Claims /U.S. Patent Claims/Class CAB Abstracts Aug. 1971+ 1976-Sep. 1978 Jan. 1975+ 1969+ 1970+ Jan. 1972+ Jan. 1973+ 1974+ N/A 1950-1970 1861+ 1973+ Jul. 1974+ N/A 1971+ 1973+ Jun. 1974+ 1969+ Jul. 1973+ 1964+ 1964+ 1970+ 1972+ Oct. 1976+ Jul. 1971+ Jul. 1971+ 1972+ Jan. 1974+ Most Recent 2 Yrs, Jul. 1974+ 1970+ 1969+ 1966+ 1975+ Abstracts Weekly 1971 + Oct. 1975+ 1973+ ------- Appendix II On-Line Databases Searched (cont'd) Lockheed Information Systems (DIALOG) Search Strategy chlororm trichloromethane tri(W)chloro(W) methane trichloro(W)methane tri(W)chloromethane R(W)20 trichcloroform tri(W)chloroform 67-66-3 (in appropriate files) 8013-54-5 (in appropriate files) ------- Database Appendix II On-Line Databases Searched (cont'd) Systems Development Corporation (OMIT) Coverage Period of File + indicates that the database is continually updated. Apilit Apipat Chemdex Crecord Fedreg Libcon Paperchem P/E News Safety Science Titus World Patent Index Search Strategy (RN)67-66-3 (in appropriate files) (RN) 8013-54-5 (in appropriate files) chloroform trichlororaethane R20 trichloroform 1974+ 1964+ 1972+ 1976+ Mar. 1977+ 1968+ 1968+ 1975 Jun. 1975+ 1970+ 1963+ All search statements were combined with the logical operator "or" before printout. ------- |